# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	43	4.023155e-27	1.2311789917441859e-24	2.280449	218	0.01240328	262	0.0000017287289696183205	1.402829	97	118	0.008815778	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	44	4.042509e-27	1.2089858166136363e-24	2.117559	257	0.01462221	308	0.00000811267303409091	1.389391	92	113	0.008361356	
GO Biological Process	viral gene expression	67	4.772868e-21	9.374055225671644e-19	2.036904	215	0.01223259	163	4.306956038711656e-10	1.478101	110	127	0.009997273	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	72	6.560818e-20	1.1990806119722222e-17	2.170963	174	0.009899863	452	0.0003211517998230088	1.38148	68	84	0.006180133	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	73	1.929446e-19	3.478024645753424e-17	2.203367	164	0.009330906	310	0.000008605523312580645	1.428295	77	92	0.006998091	
GO Biological Process	cotranslational protein targeting to membrane	78	6.763171e-19	1.140981630628205e-16	2.13907	170	0.00967228	252	0.000001150953501547619	1.44533	83	98	0.007543397	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	90	8.710182e-17	1.2735253882000001e-14	5.056053	42	0.002389622	948	0.03874799417616034	1.706535	11	11	0.0009997273	
GO Biological Process	protein targeting to ER	97	3.057598e-16	4.147931142474227e-14	2.006406	168	0.009558489	442	0.0002774726091470588	1.351711	80	101	0.007270744	
GO Biological Process	maintenance of protein localization in organelle	123	2.394731e-14	2.5619727828455284e-12	2.825525	73	0.004153391	469	0.00045043397287846483	1.596436	29	31	0.002635645	
GO Biological Process	termination of RNA polymerase II transcription	127	3.890462e-14	4.0310700360629915e-12	2.18722	117	0.006656805	475	0.0004923402450736843	1.409746	57	69	0.005180405	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	129	4.665057e-14	4.758719772325582e-12	2.699445	77	0.004380974	913	0.0335029293033954	1.493218	21	24	0.00190857	
GO Biological Process	mitochondrial translational termination	134	9.43319e-14	9.263533373880596e-12	2.037915	134	0.007624033	458	0.00035401876058951964	1.373074	70	87	0.006361901	
GO Biological Process	mitochondrial translational elongation	138	1.299515e-13	1.2391534699275363e-11	2.040781	132	0.007510241	490	0.0006326584019999999	1.365228	68	85	0.006180133	
GO Biological Process	IRE1-mediated unfolded protein response	160	6.77123e-13	5.5689134731249997e-11	2.154955	109	0.006201639	880	0.028226967157954544	1.324035	45	58	0.004089794	
GO Biological Process	gene silencing by miRNA	196	7.001253e-12	4.700484093214286e-10	2.040325	113	0.006429222	656	0.005422793810823171	1.43504	37	44	0.003362719	
GO Biological Process	positive regulation of DNA-templated transcription, elongation	223	5.180442e-11	3.056925393632287e-9	3.178562	45	0.00256031	704	0.007769221264914772	1.564323	22	24	0.001999455	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	226	5.771783e-11	3.360658960044248e-9	2.319298	77	0.004380974	913	0.0335029293033954	1.493218	21	24	0.00190857	
GO Biological Process	'de novo' protein folding	247	1.655576e-10	8.820131410526316e-9	2.307782	74	0.004210287	895	0.03012317112178771	1.413986	29	35	0.002635645	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	267	3.345145e-10	1.6486428110486892e-8	2.1781	81	0.004608557	812	0.01632044975	1.509627	23	26	0.002090339	
GO Biological Process	cytoplasmic translation	279	5.108846e-10	2.409580806953405e-8	2.291256	71	0.004039599	697	0.007392635578479197	1.428727	36	43	0.003271835	
GO Cellular Component	mitochondrial ribosome	36	5.30063e-18	2.5443024e-16	2.354073	131	0.007453345	97	0.0004196763315463917	1.365228	68	85	0.006180133	
GO Cellular Component	mitochondrial large ribosomal subunit	50	5.588948e-13	1.9315404288e-11	2.479156	82	0.004665453	185	0.02179946724324324	1.338458	40	51	0.003635372	
GO Cellular Component	cytoplasmic stress granule	52	1.516434e-12	5.03922683076923e-11	2.070899	116	0.006599909	96	0.00037889658	1.5081	38	43	0.003453604	
GO Cellular Component	nuclear ubiquitin ligase complex	55	3.126134e-12	9.82174464e-11	2.423932	80	0.004551661	199	0.031462581708542714	1.365228	32	40	0.002908298	
GO Cellular Component	DNA-directed RNA polymerase III complex	70	6.859828e-10	1.6933975405714286e-8	3.558786	34	0.001934456	202	0.03307563944554456	1.526899	17	19	0.001545033	
GO Cellular Component	INO80-type complex	78	2.109872e-9	4.67417796923077e-8	2.938436	42	0.002389622	116	0.0011692708634482758	1.632337	22	23	0.001999455	
GO Cellular Component	Ino80 complex	100	8.2233e-8	0.00000142098624	3.164357	30	0.001706873	135	0.0024626688	1.706535	16	16	0.001454149	
GO Cellular Component	proteasome accessory complex	102	9.647539e-8	0.0000016344066070588236	2.406143	47	0.002674101	184	0.021830143304347824	1.493218	21	24	0.00190857	
GO Cellular Component	MLL1 complex	112	3.539937e-7	0.0000054616170857142855	2.137368	55	0.003129267	141	0.003412239931914894	1.529997	26	29	0.002362992	
GO Cellular Component	spliceosomal tri-snRNP complex	114	5.049378e-7	0.000007653794021052633	2.202317	50	0.002844788	214	0.04225536538317757	1.412304	24	29	0.002181223	
GO Cellular Component	U12-type spliceosomal complex	151	0.000005891716	0.00006742308111258278	2.120069	44	0.002503414	208	0.03679309107692308	1.443991	22	26	0.001999455	
GO Cellular Component	HOPS complex	206	0.00008266125	0.0006933914563106797	2.114642	33	0.00187756	219	0.0482562621369863	1.584639	13	14	0.001181496	
GO Molecular Function	rRNA binding	22	2.907146e-12	5.57907746e-10	2.382741	83	0.004722349	158	0.027654955088607595	1.336785	47	60	0.004271562	
GO Molecular Function	NF-kappaB binding	34	2.838951e-10	3.525309153529412e-8	2.30866	72	0.004096495	135	0.013416677854814816	1.523692	25	28	0.002272108	
Human Phenotype	Exercise intolerance	4	5.530184e-12	9.225729458e-9	2.027068	116	0.006599909	432	0.031941318539351844	1.29209	53	70	0.004816868	
Human Phenotype	Increased CSF lactate	21	3.918095e-10	1.2450213302380953e-7	2.029814	95	0.005405098	299	0.00545241902909699	1.382881	47	58	0.004271562	
Human Phenotype	Abnormality of renal resorption	73	4.563008e-7	0.00004171089367671233	2.570572	37	0.002105143	401	0.024428288755610972	1.60615	16	17	0.001454149	
Human Phenotype	Abnormality of glycolysis	93	0.000001831776	0.00013143485212903226	2.615174	32	0.001820665	454	0.041029851790748896	1.706535	11	11	0.0009997273	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	15	2.793117e-11	1.7051048246e-8	3.241648	45	0.00256031	300	0.010027403373333334	1.706535	15	15	0.001363265	
Mouse Phenotype	increased adrenal gland tumor incidence	7	2.999057e-17	4.096283425285714e-14	3.52281	65	0.003698225	585	0.023991850405128204	1.60615	16	17	0.001454149	
Mouse Phenotype	increased circulating fructosamine level	258	0.0001080461	0.0040039874500000005	2.083566	33	0.00187756	678	0.03936482277433628	1.706535	11	11	0.0009997273