# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	13	2.533595e-22	2.5645828157692304e-19	3.048342	105	0.01657982	143	0.000003519202470769231	1.818101	63	118	0.01142546	
GO Biological Process	mRNA catabolic process	14	9.328083e-22	8.767731728357143e-19	2.263488	173	0.02731723	158	0.000007084976333860759	1.58276	99	213	0.0179543	
GO Biological Process	RNA catabolic process	15	5.953847e-21	5.223111511533333e-18	2.1294	190	0.03000158	163	0.00000923538985030675	1.540171	109	241	0.01976786	
GO Biological Process	nuclear-transcribed mRNA catabolic process	19	9.318588e-21	6.453857868000001e-18	2.300547	159	0.02510658	185	0.000017359253218378382	1.582275	92	198	0.0166848	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	28	5.8332e-17	2.7413956714285713e-14	2.492524	109	0.01721143	401	0.008745487807730672	1.53692	51	113	0.009249184	
GO Biological Process	rRNA processing	34	3.009809e-16	1.1648846067941176e-13	2.012606	165	0.026054	165	0.000009415184748484849	1.526994	113	252	0.02049329	
GO Biological Process	protein targeting to ER	39	1.593517e-15	5.376689795641026e-13	2.751048	83	0.01310595	223	0.00005413079158923766	1.786956	53	101	0.009611897	
GO Biological Process	ATP metabolic process	43	2.395423e-15	7.33055145511628e-13	2.085816	142	0.02242223	313	0.0017804892155910545	1.44519	87	205	0.01577802	
GO Biological Process	regulation of DNA-templated transcription in response to stress	47	1.251443e-14	3.503774135531915e-12	2.264141	112	0.01768514	415	0.009721805783132531	1.51666	53	119	0.009611897	
GO Biological Process	viral transcription	48	1.90638e-14	5.226261337500001e-12	2.52537	89	0.01405337	142	0.000003384312242042253	1.838277	61	113	0.01106275	
GO Biological Process	transcription-coupled nucleotide-excision repair	49	2.104172e-14	5.650775377142858e-12	2.850786	72	0.01136902	171	0.000010839853222807017	2.00588	43	73	0.007798332	
GO Biological Process	protein localization to endoplasmic reticulum	51	4.346063e-14	1.1213694709215687e-11	2.366824	98	0.0154745	244	0.00013523617553688524	1.675204	61	124	0.01106275	
GO Biological Process	cotranslational protein targeting to membrane	52	5.021134e-14	1.2706365828076923e-11	2.688917	77	0.01215853	257	0.00027258576646692605	1.737414	50	98	0.009067827	
GO Biological Process	protein complex disassembly	53	6.179664e-14	1.534305633509434e-11	2.082361	128	0.02021159	284	0.0006681264477816902	1.542037	72	159	0.01305767	
GO Biological Process	viral gene expression	55	7.734763e-14	1.8505772057636366e-11	2.41897	92	0.01452708	203	0.000031497077733497536	1.716073	64	127	0.01160682	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	57	1.633591e-13	3.7713024507017544e-11	2.470684	86	0.01357966	575	0.04540633097391304	1.446513	48	113	0.008705114	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	58	2.309116e-13	5.2389064558620686e-11	2.469422	85	0.01342176	240	0.00009077944500833333	1.751314	54	105	0.009793254	
GO Biological Process	cellular protein complex disassembly	61	2.491682e-13	5.375089088196721e-11	2.242081	103	0.01626401	321	0.002179723169906542	1.567534	58	126	0.01051868	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	65	9.46796e-13	1.916752086769231e-10	2.647353	71	0.01121112	275	0.0004612395064145454	1.73968	47	92	0.008523758	
GO Biological Process	DNA-dependent DNA replication	66	1.092912e-12	2.1790346981818182e-10	2.106672	112	0.01768514	105	4.171866698095238e-8	1.954364	66	115	0.01196953	
GO Cellular Component	ribosomal subunit	27	6.260671e-18	4.00682944e-16	2.348959	130	0.0205274	49	0.00000424387278367347	1.619834	88	185	0.01595938	
GO Cellular Component	ribosome	31	7.936189e-16	4.4237853522580646e-14	2.019144	159	0.02510658	44	5.418026181818182e-7	1.587231	110	236	0.01994922	
GO Cellular Component	mitochondrial ribosome	38	4.143267e-13	1.884096151578947e-11	2.992336	60	0.009474183	104	0.01506819156923077	1.562446	39	85	0.007072905	
GO Cellular Component	large ribosomal subunit	45	6.679442e-11	2.564905728e-9	2.306698	77	0.01215853	94	0.008203332561702128	1.510191	51	115	0.009249184	
GO Cellular Component	endopeptidase complex	52	1.366915e-9	4.542363692307692e-8	2.488643	57	0.009000474	105	0.014931769782857143	1.628637	33	69	0.005984766	
GO Cellular Component	histone acetyltransferase complex	54	2.508604e-9	8.0275328e-8	2.075995	81	0.01279015	54	0.0000288188864	1.896641	44	79	0.007979688	
GO Cellular Component	peptidase complex	56	7.666326e-9	2.3656091657142858e-7	2.177417	68	0.01073741	72	0.002124642	1.663969	43	88	0.007798332	
GO Cellular Component	proteasome complex	57	8.437132e-9	2.557783174736842e-7	2.402679	55	0.008684668	115	0.022720525356521738	1.602509	32	68	0.00580341	
GO Cellular Component	small ribosomal subunit	59	1.140312e-8	3.339761247457627e-7	2.402923	54	0.008526765	64	0.00070336701	1.797258	38	72	0.006891549	
GO Cellular Component	catalytic step 2 spliceosome	60	1.578652e-8	4.54651776e-7	2.072468	73	0.01152692	135	0.0461876992	1.45436	41	96	0.007435618	
GO Cellular Component	DNA-directed RNA polymerase III complex	63	2.761486e-8	7.5743616e-7	5.228848	18	0.002842255	125	0.031753755647999996	2.150736	12	19	0.002176279	
GO Cellular Component	methyltransferase complex	66	3.482735e-8	9.118433454545454e-7	2.01928	74	0.01168483	58	0.00019596532965517245	1.758798	47	91	0.008523758	
GO Cellular Component	outer mitochondrial membrane protein complex	68	4.3868e-8	0.000001114763294117647	4.795393	19	0.003000158	131	0.040300904061068704	2.270221	10	15	0.001813565	
GO Cellular Component	pre-autophagosomal structure membrane	72	8.768743e-8	0.00000210449832	3.858783	23	0.00363177	112	0.0197775	2.341166	11	16	0.001994922	
GO Cellular Component	PcG protein complex	73	1.166866e-7	0.0000027621156821917807	2.177753	57	0.009000474	87	0.0067213976275862074	1.850724	25	46	0.004533914	
GO Cellular Component	zona pellucida receptor complex	75	1.310873e-7	0.000003020251392	9.816625	10	0.00157903	137	0.04720206061313868	2.648591	7	9	0.001269496	
GO Cellular Component	retromer complex	82	4.080482e-7	0.000008598869385365854	2.989931	29	0.004579188	93	0.008195066012903224	2.270221	14	21	0.002538992	
GO Cellular Component	host cell	88	0.000001477716	0.00002901696872727273	2.04878	54	0.008526765	115	0.022720525356521738	1.602509	32	68	0.00580341	
GO Cellular Component	Cul4-RING E3 ubiquitin ligase complex	90	0.000001788073	0.0000343310016	2.663782	31	0.004894994	74	0.0023664656432432433	2.128332	20	32	0.003627131	
GO Cellular Component	chromatin silencing complex	99	0.00000453731	0.00007919668363636363	5.321204	12	0.001894837	109	0.017704152660550462	2.979665	7	8	0.001269496	
GO Molecular Function	unfolded protein binding	6	4.222561e-15	2.971275423666667e-12	2.701261	83	0.01310595	49	0.0005251529530204081	1.702666	53	106	0.009611897	
GO Molecular Function	structural constituent of ribosome	8	1.477778e-13	7.798973395e-11	2.185658	111	0.01752724	38	0.00003674481040526315	1.639604	78	162	0.01414581	
GO Molecular Function	ribonucleoprotein complex binding	9	3.331856e-11	1.563010670222222e-8	2.188332	89	0.01405337	78	0.02415450043846154	1.510191	51	115	0.009249184	
GO Molecular Function	protein binding involved in protein folding	54	0.000003561483	0.00027845520788888887	2.85377	26	0.004105479	98	0.050075332571428564	2.017974	16	27	0.002901705	
GO Molecular Function	NF-kappaB binding	66	0.000006777083	0.0004335279458484849	2.580691	29	0.004579188	48	0.0004475736042916666	2.43238	20	28	0.003627131	
Human Phenotype	Increased serum lactate	2	1.083521e-13	3.6151678165e-10	2.505798	85	0.01342176	23	0.0012675459243043478	1.736719	51	100	0.009249184	
Human Phenotype	Progressive external ophthalmoplegia	3	5.071677e-13	1.1281100207e-9	5.532881	29	0.004579188	42	0.011464638212142858	2.724266	12	15	0.002176279	
Human Phenotype	External ophthalmoplegia	22	2.786807e-7	0.00008452892323181819	2.58348	38	0.006000316	44	0.015369390093181818	2.128332	20	32	0.003627131	
Human Phenotype	Ependymoma	64	0.00003266307	0.00340563540796875	4.725189	11	0.001736934	40	0.009192357785	3.405332	8	8	0.001450852	
Mouse Phenotype Single KO	increased B cell derived lymphoma incidence	50	0.000002131287	0.00039032390117999996	2.03786	53	0.008368862	54	0.00461217571537037	1.986444	28	48	0.005077983	
Mouse Phenotype	increased incidence of corneal inflammation	20	1.905429e-10	9.108903334499999e-8	3.499899	37	0.005842413	93	0.045343186429032255	2.270221	14	21	0.002538992