# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	gene silencing by miRNA	14	9.425411e-19	8.859213096357143e-16	2.44576	127	0.007706778	363	0.00009193935920110193	1.547738	40	44	0.003626802	
GO Biological Process	posttranscriptional gene silencing by RNA	31	9.815793e-17	4.166645809258065e-14	2.225275	136	0.008252928	322	0.00003064729465341615	1.535599	46	51	0.004170822	
GO Biological Process	posttranscriptional gene silencing	33	1.16268e-16	4.636274581818182e-14	2.212929	137	0.008313611	303	0.000021062234599339933	1.538809	47	52	0.004261492	
GO Biological Process	positive regulation of mRNA catabolic process	52	3.122056e-14	7.900602866153846e-12	2.399307	97	0.00588628	591	0.0061507147642978	1.566311	23	25	0.002085411	
GO Biological Process	regulation of mRNA catabolic process	96	2.344646e-11	3.213874657708333e-9	2.019392	110	0.006675162	440	0.0005110195966818181	1.592672	29	31	0.002629431	
GO Biological Process	negative regulation of Notch signaling pathway	126	2.587887e-10	2.702698812142857e-8	2.046732	95	0.005764913	766	0.021270630199738905	1.444555	28	33	0.002538761	
GO Biological Process	production of miRNAs involved in gene silencing by miRNA	184	6.256509e-9	4.474424017989131e-7	2.138494	72	0.004369197	310	0.00002413897572096774	1.702512	27	27	0.002448091	
GO Biological Process	regulation of receptor biosynthetic process	192	9.080022e-9	6.2231254946875e-7	2.611099	47	0.002852115	879	0.03875737186575654	1.53226	18	20	0.001632061	
GO Biological Process	purine nucleobase biosynthetic process	474	0.000009871241	0.0002740414774662447	2.530098	29	0.001759816	821	0.026960370769792935	1.702512	12	12	0.001088041	
GO Biological Process	chaperone mediated protein folding requiring cofactor	572	0.00003415674	0.0007857841637412587	2.744713	22	0.001335032	821	0.026960370769792935	1.702512	12	12	0.001088041	
GO Cellular Component	nuclear transcriptional repressor complex	51	4.634353e-9	1.57022784e-7	2.030469	83	0.005036713	62	0.000005456750864516129	1.702512	29	29	0.002629431	
GO Molecular Function	NF-kappaB binding	24	2.702541e-10	4.7542200425e-8	2.359748	69	0.004187147	124	0.015355584241935484	1.5201	25	28	0.002266751	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase inhibitor activity	264	0.0008462386	0.013533406701515151	2.16641	22	0.001335032	147	0.04831111099319728	1.702512	12	12	0.001088041	
Human Phenotype	Delayed CNS myelination	195	0.000008602619	0.0002943860337794872	2.086703	44	0.002670065	197	0.01963877449238579	1.702512	14	14	0.001269381	
Human Phenotype	Lower limb amyotrophy	344	0.0001334971	0.0025896108962209304	2.0341	34	0.002063232	197	0.01963877449238579	1.702512	14	14	0.001269381	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	107	2.248994e-9	1.9246764540186918e-7	2.503864	55	0.003337581	292	0.0036781348390410957	1.702512	17	17	0.001541391	
Mouse Phenotype Single KO	absent stapedial artery	108	2.326259e-9	1.9723660799074075e-7	2.526102	54	0.003276898	322	0.0056820493142857136	1.702512	16	16	0.001450721	
Mouse Phenotype Single KO	increased circulating interleukin-4 level	128	2.021939e-8	0.000001446476204921875	4.371224	22	0.001335032	567	0.04626847991005291	1.702512	11	11	0.0009973706	
Mouse Phenotype Single KO	decreased spongiotrophoblast size	154	1.56766e-7	0.000009321469233766232	2.2729	51	0.003094848	444	0.019402688929279276	1.607928	17	18	0.001541391	
Mouse Phenotype Single KO	abnormal cervical rib	171	2.977993e-7	0.000015947065439181287	2.414724	43	0.002609382	567	0.04626847991005291	1.702512	11	11	0.0009973706	
Mouse Phenotype Single KO	double ureter	285	0.00001033091	0.00033193032585964913	2.016024	47	0.002852115	567	0.04626847991005291	1.702512	11	11	0.0009973706	
Mouse Phenotype	subcutaneous edema	86	6.112436e-11	6.795465185581395e-9	2.211446	85	0.00515808	916	0.039621712961790394	1.41876	25	30	0.002266751	
Mouse Phenotype	abnormal stapedial artery morphology	111	1.265186e-9	1.0897696708108109e-7	2.302291	67	0.004065781	399	0.0005683801234586466	1.702512	20	20	0.001813401	
Mouse Phenotype	absent stapedial artery	112	1.356744e-9	1.1581990521428572e-7	2.314798	66	0.004005097	428	0.00090274962	1.702512	19	19	0.001722731	
Mouse Phenotype	decreased spongiotrophoblast size	140	8.640087e-9	5.900562271928571e-7	2.404594	55	0.003337581	619	0.008969396520678513	1.612906	18	19	0.001632061	
Mouse Phenotype	increased circulating interleukin-4 level	143	1.322934e-8	8.845155226573426e-7	3.861755	26	0.001577766	677	0.013946832653175775	1.702512	13	13	0.001178711	
Mouse Phenotype	delayed hepatic development	257	0.000001927716	0.00007171553570428014	2.003261	56	0.003398264	618	0.008969625849514563	1.702512	14	14	0.001269381	
Mouse Phenotype	increased T-helper 2 cell number	564	0.0004240413	0.007188402250531915	2.118846	26	0.001577766	965	0.04834413141450777	1.702512	10	10	0.0009067005