# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	4.577838e-25	6.0239770242e-22	3.190076	111	0.02202818	267	0.004703763898277154	1.681486	45	113	0.01011918	
GO Biological Process	regulation of DNA-templated transcription in response to stress	15	6.337179e-23	5.5593958974e-20	2.921786	115	0.02282199	264	0.004275170687045455	1.667669	47	119	0.01056892	
GO Biological Process	cellular response to topologically incorrect protein	31	3.704932e-20	1.572683877032258e-17	2.726249	112	0.02222663	433	0.04109397670438799	1.488471	49	139	0.01101866	
GO Biological Process	regulation of cellular amino acid metabolic process	32	3.989088e-20	1.6403877809999998e-17	4.464264	58	0.01151022	260	0.0040906077522307694	1.970452	28	60	0.00629638	
GO Biological Process	positive regulation of endoplasmic reticulum unfolded protein response	38	2.600568e-18	9.00549324e-16	4.957953	47	0.009327247	356	0.023746428299438203	2.923198	9	13	0.002023836	
GO Biological Process	response to topologically incorrect protein	39	2.621544e-18	8.845358332307692e-16	2.37226	130	0.02579877	275	0.005410885098181818	1.524755	65	180	0.0146166	
GO Biological Process	response to endoplasmic reticulum stress	48	3.868977e-17	1.0606639238125e-14	2.008742	175	0.03472911	170	0.00033857627083529407	1.540137	89	244	0.02001349	
GO Biological Process	response to unfolded protein	57	1.719295e-15	3.969158404385965e-13	2.292328	116	0.02302044	339	0.016641674914159292	1.504229	57	160	0.01281763	
GO Biological Process	rRNA processing	61	1.821386e-14	3.929117766229509e-12	2.06954	135	0.02679103	166	0.0002310860709819277	1.54151	92	252	0.0206881	
GO Biological Process	rRNA metabolic process	62	1.918072e-14	4.070953136774194e-12	2.049289	138	0.02738639	167	0.0002406456458802395	1.532453	94	259	0.02113785	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	65	4.984058e-14	1.009003372646154e-11	2.871294	69	0.01369319	198	0.0007442085741919192	1.948799	36	78	0.008095345	
GO Biological Process	macromolecular complex disassembly	70	2.972074e-13	5.587074538e-11	2.065207	123	0.02440961	173	0.0003538226909248555	1.613796	73	191	0.01641556	
GO Biological Process	positive regulation of establishment of protein localization to telomere	71	3.399154e-13	6.299924998028169e-11	17.02236	14	0.002778329	403	0.03081584089255583	3.284087	7	9	0.001574095	
GO Biological Process	antigen processing and presentation of peptide antigen via MHC class I	72	3.716772e-13	6.792917048333333e-11	2.904885	63	0.01250248	246	0.003013849098414634	1.802821	38	89	0.008545087	
GO Biological Process	regulation of mRNA stability	73	4.800525e-13	8.653439517123288e-11	2.085738	118	0.02341734	256	0.003765201632773438	1.593885	57	151	0.01281763	
GO Biological Process	regulation of RNA stability	74	5.664155e-13	1.0072245357432431e-10	2.044756	123	0.02440961	251	0.0031447210435856573	1.583399	60	160	0.01349224	
GO Biological Process	negative regulation of protein ubiquitination	80	1.112554e-12	1.83001226075e-10	2.23235	98	0.0194483	147	0.0001210757799659864	1.774631	58	138	0.0130425	
GO Biological Process	antigen processing and presentation of exogenous peptide antigen via MHC class I	86	3.025362e-12	4.62915564627907e-10	3.04517	54	0.01071641	286	0.007297139408041959	1.825901	32	74	0.007195862	
GO Biological Process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	87	3.049365e-12	4.6122521879310345e-10	3.082998	53	0.01051796	287	0.0073950553888501745	1.843582	31	71	0.006970992	
GO Biological Process	cellular protein complex disassembly	91	4.570368e-12	6.608953023296704e-10	2.325403	85	0.01686843	394	0.027016125028172588	1.54151	46	126	0.01034405	
GO Cellular Component	proteasome complex	32	2.490066e-14	1.34463564e-12	3.239293	59	0.01170867	44	0.000268014096	2.049104	33	68	0.007420733	
GO Cellular Component	endopeptidase complex	33	2.548919e-14	1.3347066763636365e-12	3.237464	59	0.01170867	49	0.00035694343836734695	2.019407	33	69	0.007420733	
GO Cellular Component	proteasome core complex	35	3.387057e-14	1.6722384274285714e-12	7.080393	26	0.005159754	90	0.023409139199999998	2.287132	13	24	0.002923319	
GO Cellular Component	peptidase complex	43	1.319312e-11	5.301793339534884e-10	2.61584	65	0.01289938	63	0.0028423817142857145	1.775326	37	88	0.008320216	
GO Cellular Component	mitochondrial ribosome	46	2.118386e-10	7.957763060869566e-9	2.945928	47	0.009327247	76	0.013415850947368422	1.688959	34	85	0.007645604	
GO Cellular Component	ribosomal subunit	52	1.432638e-9	4.760766276923077e-8	2.021097	89	0.01766223	60	0.002330987328	1.529192	67	185	0.01506634	
GO Cellular Component	methyltransferase complex	57	6.671226e-9	2.0224348294736841e-7	2.229171	65	0.01289938	36	0.0000036915417600000004	2.087999	45	91	0.01011918	
GO Cellular Component	peroxisomal part	60	2.584804e-8	7.44423552e-7	2.056243	72	0.01428855	103	0.048691567223300966	1.560451	34	92	0.007645604	
GO Cellular Component	Holliday junction resolvase complex	62	3.136004e-8	8.740346632258064e-7	23.53849	7	0.001389165	80	0.01606618368	4.222397	5	5	0.001124353	
GO Cellular Component	ficolin-1-rich granule lumen	63	3.383451e-8	9.280322742857144e-7	2.030353	73	0.014487	85	0.021489611294117646	1.532322	45	124	0.01011918	
GO Cellular Component	large ribosomal subunit	71	1.818736e-7	0.0000044264448	2.146051	57	0.01131177	69	0.00819948772173913	1.615526	44	115	0.009894311	
GO Cellular Component	preribosome	83	0.000001057415	0.00002201461590361446	2.244868	45	0.008930343	67	0.0074022645492537315	1.777851	32	76	0.007195862	
GO Cellular Component	U1 snRNP	84	0.000001264362	0.000026009732571428572	3.665499	20	0.003969041	58	0.0013386363144827587	2.889009	13	19	0.002923319	
GO Cellular Component	histone methyltransferase complex	96	0.000005553876	0.000099969768	2.012503	50	0.009922604	49	0.00035694343836734695	2.019407	33	69	0.007420733	
GO Cellular Component	PcG protein complex	99	0.000006163152	0.00010757501672727272	2.112767	44	0.008731891	61	0.0026226210098360654	2.111199	23	46	0.005172026	
GO Cellular Component	nuclear ubiquitin ligase complex	101	0.000006801981	0.00011637448681188118	2.747765	26	0.005159754	98	0.04331969044897959	1.900079	18	40	0.004047673	
GO Cellular Component	outer mitochondrial membrane protein complex	113	0.00002653923	0.0004058388446017699	4.123624	13	0.002579877	102	0.04753932988235293	2.533438	9	15	0.002023836	
GO Cellular Component	mitochondrial nucleoid	134	0.00007150359	0.0009220761456716417	2.381124	26	0.005159754	77	0.013337637568831169	2.010665	20	42	0.004497414	
GO Cellular Component	U2-type spliceosomal complex	136	0.00008162396	0.0010371044329411765	2.277019	28	0.005556658	73	0.012535136876712328	2.111199	18	36	0.004047673	
GO Cellular Component	U4 snRNP	172	0.0005858648	0.005885897525581395	4.412947	8	0.001587617	66	0.007244917527272728	3.377918	8	10	0.001798966	
GO Molecular Function	structural constituent of ribosome	28	1.169585e-9	1.763567096428571e-7	2.078757	84	0.01666997	51	0.0037649941631372552	1.589915	61	162	0.01371711	
GO Molecular Function	endoribonuclease activity	33	2.731635e-8	0.0000034948372636363633	2.672893	42	0.008334987	53	0.00422832184754717	2.035799	27	56	0.006071509	
GO Molecular Function	proteasome binding	43	1.304285e-7	0.00001280625876744186	4.254148	20	0.003969041	63	0.016790491904761905	3.166798	9	12	0.002023836	
Human Phenotype	Increased serum lactate	45	1.369306e-7	0.00002030528652888889	2.14892	58	0.01151022	37	0.036689398424324324	1.688959	40	100	0.008994828	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	227	0.0006901433	0.020287780796916302	2.801119	14	0.002778329	34	0.033105381047058825	2.902898	11	16	0.002473578	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	97	3.412593e-7	0.000032215581547422674	2.228862	50	0.009922604	25	0.00124764088372	2.183999	30	58	0.006746121	
Mouse Phenotype Single KO	dilated renal glomerular capsule	159	0.00001525115	0.000878331953144654	4.070257	14	0.002778329	19	0.0005900158726842104	3.870531	11	12	0.002473578	
Mouse Phenotype Single KO	abnormal DNA replication	252	0.0002850641	0.010358460173412699	2.543504	19	0.003770589	51	0.02716170885882353	2.570155	14	23	0.00314819	
Mouse Phenotype	absent hypoglossal nerve	55	8.686985e-11	1.5101138833636365e-8	5.371316	24	0.00476285	107	0.044362736192523365	2.814931	10	15	0.002248707	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	108	3.412593e-7	0.000030210927474999996	2.228862	50	0.009922604	31	0.001050553119	2.183999	30	58	0.006746121	
Mouse Phenotype	dilated renal glomerular capsule	173	0.00001222904	0.0006758488522543353	3.531204	17	0.003373685	28	0.0005850328095	3.619198	12	14	0.002698448