# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	13	1.217533e-42	1.2324243651538464e-39	2.60794	270	0.0180084	522	0.004441119645019157	1.325945	78	113	0.00797954	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	1.304176e-36	7.800750901818182e-34	2.365299	277	0.01847529	565	0.006406364824424779	1.307517	81	119	0.008286445	
GO Biological Process	mRNA catabolic process	27	1.75123e-35	8.534976137037038e-33	2.044819	370	0.02467818	204	1.609719183382353e-7	1.379816	153	213	0.01565217	
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	1.226567e-33	5.206579081612903e-31	2.071832	339	0.02261055	219	6.585887222374429e-7	1.37763	142	198	0.01452685	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	34	2.198843e-32	8.51016912852941e-30	2.562959	209	0.01393984	280	0.00001916182092392857	1.432551	88	118	0.009002558	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	36	5.535978e-31	2.0235537361666664e-28	2.511945	207	0.01380644	636	0.015103202938522013	1.291947	76	113	0.007774936	
GO Biological Process	cellular response to topologically incorrect protein	40	9.93571e-28	3.2686001972499997e-25	2.127045	260	0.01734143	301	0.0000541801933488372	1.381957	100	139	0.01023018	
GO Biological Process	endoplasmic reticulum unfolded protein response	42	2.0148e-27	6.312560285714285e-25	2.267291	223	0.01487361	345	0.0001718247676898551	1.398565	83	114	0.008491049	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	50	4.752122e-26	1.2506634679599999e-23	2.47547	177	0.01180551	488	0.003147290342418033	1.40375	57	78	0.005831202	
GO Biological Process	regulation of hematopoietic stem cell differentiation	59	5.02242e-24	1.1201699115254239e-21	2.388435	174	0.01160542	808	0.04577556837871286	1.268181	68	103	0.006956522	
GO Biological Process	cellular response to unfolded protein	61	6.460422e-24	1.3936507065245902e-21	2.091705	231	0.01540719	367	0.0002231676761035422	1.381158	87	121	0.008900256	
GO Biological Process	viral gene expression	80	1.103964e-21	1.8158827844999997e-19	2.154594	194	0.01293937	314	0.00008389977243312102	1.391533	92	127	0.009411765	
GO Biological Process	protein targeting to ER	90	4.132064e-21	6.041536686222223e-19	2.296068	164	0.01093844	222	8.005182810360361e-7	1.521521	80	101	0.008184143	
GO Biological Process	protein localization to endoplasmic reticulum	97	1.994877e-20	2.7062460250515462e-18	2.060688	202	0.01347295	223	8.32899200044843e-7	1.471673	95	124	0.00971867	
GO Biological Process	cotranslational protein targeting to membrane	110	7.037637e-20	8.418933207545455e-18	2.286332	155	0.01033816	341	0.00016237503672140763	1.43089	73	98	0.007468031	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	112	8.657757e-20	1.0172091460982142e-17	2.04021	200	0.01333956	691	0.02186368802170767	1.307861	64	94	0.006547315	
GO Biological Process	regulation of mitochondrial membrane permeability	113	9.122376e-20	1.0623127945486724e-17	2.146334	177	0.01180551	338	0.0001499446248106509	1.499897	57	73	0.005831202	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	121	4.992606e-19	5.429562178016528e-17	2.299467	146	0.009737878	287	0.000026261879386759583	1.48245	71	92	0.007263427	
GO Biological Process	regulation of cellular amino acid metabolic process	127	2.549142e-18	2.6412724077165355e-16	2.690364	104	0.00693657	727	0.027651511701513067	1.37666	43	60	0.004398977	
GO Biological Process	regulation of necroptotic process	128	2.612152e-18	2.685414700625e-16	4.585175	51	0.003401587	770	0.03893891652727273	1.632783	17	20	0.00173913	
GO Cellular Component	nuclear ubiquitin ligase complex	41	4.707466e-20	1.9840246946341462e-18	3.1612	89	0.005936104	142	0.010080671323943661	1.488714	31	40	0.003171355	
GO Cellular Component	catalytic step 2 spliceosome	45	2.641853e-19	1.0144715519999999e-17	2.122556	177	0.01180551	66	0.0000029149370181818182	1.500719	75	96	0.007672634	
GO Cellular Component	large ribosomal subunit	48	8.352153e-18	3.00677508e-16	2.100531	166	0.01107183	64	0.00000142789635	1.469922	88	115	0.009002558	
GO Cellular Component	PcG protein complex	61	2.923387e-15	8.281332354098361e-14	2.146379	133	0.008870806	164	0.021180570146341463	1.419811	34	46	0.003478261	
GO Cellular Component	mitochondrial ribosome	63	5.928039e-15	1.6259764114285713e-13	2.317249	110	0.007336757	143	0.010144468095104896	1.333345	59	85	0.006035806	
GO Cellular Component	endopeptidase complex	68	1.989695e-13	5.056166117647059e-12	2.139276	116	0.007736944	146	0.012116463780821917	1.364132	49	69	0.005012788	
GO Cellular Component	proteasome complex	69	8.922693e-13	2.2345526817391306e-11	2.10358	114	0.007603548	157	0.015598402853503184	1.355944	48	68	0.004910486	
GO Cellular Component	spliceosomal snRNP complex	74	7.834834e-12	1.8295396151351355e-10	2.212437	93	0.006202895	140	0.009483254125714286	1.394217	45	62	0.004603581	
GO Cellular Component	mitochondrial large ribosomal subunit	78	2.476585e-11	5.486588307692307e-10	2.480958	70	0.004668845	166	0.02348966168674699	1.393609	37	51	0.003785166	
GO Cellular Component	axon cytoplasm	96	1.392096e-9	2.5057728e-8	2.046912	87	0.005802708	170	0.02554795143529412	1.440691	30	40	0.003069054	
GO Cellular Component	anaphase-promoting complex	124	5.586735e-8	7.785385548387097e-7	2.807539	37	0.002467818	155	0.015266590141935484	1.646503	18	21	0.001841432	
GO Cellular Component	mitochondrial nucleoid	142	3.237106e-7	0.000003939238850704225	2.000681	65	0.004335356	151	0.013142893350993376	1.463559	32	42	0.003273657	
GO Cellular Component	nuclear exosome (RNase complex)	281	0.0002616496	0.001609005369395018	2.319719	23	0.001534049	174	0.02649765848275862	1.773158	12	13	0.001227621	
GO Molecular Function	unfolded protein binding	9	3.363748e-22	1.5779715617777778e-19	2.323251	169	0.01127193	83	0.0033100342657831324	1.359142	75	106	0.007672634	
GO Molecular Function	rRNA binding	10	1.293333e-21	5.460451926e-19	3.197083	95	0.00633629	101	0.009357093194059406	1.440691	45	60	0.004603581	
GO Molecular Function	ribonucleoprotein complex binding	13	2.509362e-19	8.149635664615384e-17	2.035637	196	0.01307277	81	0.0022805440528395064	1.352996	81	115	0.008286445	
GO Molecular Function	exonuclease activity	22	1.032994e-13	1.9824093945454548e-11	2.00521	139	0.009270993	103	0.00960871043300971	1.39014	55	76	0.005626598	
GO Molecular Function	snRNA binding	28	1.337462e-12	2.0167016299999998e-10	2.881447	61	0.004068565	117	0.02072979987863248	1.516516	30	38	0.003069054	
GO Molecular Function	ubiquitin-protein transferase regulator activity	140	0.000001628907	0.0000491231811	2.014733	56	0.003735076	105	0.010092518099047619	1.807925	16	17	0.001636829	
Human Phenotype	Increased serum lactate	5	1.551347e-20	2.0704277062e-17	2.191597	176	0.01173881	25	3.9946980280000005e-7	1.555946	81	100	0.008286445	
Human Phenotype	Increased CSF lactate	12	3.730279e-16	2.0743459805833335e-13	2.529796	101	0.006736477	68	0.0015590326164705885	1.523489	46	58	0.004705882	
Human Phenotype	Abnormal CSF metabolite level	13	7.473121e-16	3.8360104948461544e-13	2.427111	107	0.007136664	71	0.0021012929252112672	1.494049	49	63	0.005012788	
Human Phenotype	Increased muscle lipid content	161	0.000002698268	0.00011183566685714286	2.611235	31	0.002067632	145	0.030734540216551726	1.718719	17	19	0.00173913	
Human Phenotype	Diminished motivation	190	0.000005677987	0.00019941688026842104	2.144312	43	0.002868005	130	0.019690765396153845	1.728829	18	20	0.001841432	
Human Phenotype	Apathy	194	0.000006229818	0.00021428647172164948	2.158005	42	0.002801307	145	0.030734540216551726	1.718719	17	19	0.00173913	
Human Phenotype	Increased intramyocellular lipid droplets	239	0.00002460994	0.0006871218812552301	2.447819	28	0.001867538	117	0.014315478535042735	1.807925	16	17	0.001636829	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	302	0.00009104081	0.002011640149437086	2.393599	25	0.001667445	105	0.008756838084761905	1.814203	17	18	0.00173913	
Mouse Phenotype Single KO	decreased circulating total protein level	32	4.76196e-17	1.36266461625e-14	2.143021	151	0.01007137	192	0.022583932946354166	1.424131	43	58	0.004398977	
Mouse Phenotype Single KO	increased cellular sensitivity to oxidative stress	153	3.017769e-8	0.000001806124884509804	2.076661	70	0.004668845	186	0.01869836261344086	1.547408	29	36	0.002966752	
Mouse Phenotype Single KO	increased hepatocyte proliferation	314	0.00001306097	0.00038088949773885353	2.133729	40	0.002667912	187	0.0193371160171123	1.920921	12	12	0.001227621	
Mouse Phenotype	decreased circulating total protein level	47	1.09863e-16	2.2348939212765955e-14	2.121126	151	0.01007137	328	0.025328266635365852	1.399993	43	59	0.004398977	
Mouse Phenotype	abnormal sebaceous gland physiology	100	3.24642e-12	3.103902162e-10	2.713289	65	0.004335356	350	0.03159691962857143	1.707485	16	18	0.001636829	
Mouse Phenotype	increased number of Howell-Jolly bodies	124	1.094844e-10	8.441777003225806e-9	2.70341	56	0.003735076	321	0.024567769868224298	1.792859	14	15	0.001432225	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	132	2.375427e-10	1.7205649656818182e-8	2.459458	64	0.004268659	372	0.038249397338709676	1.536737	24	30	0.002455243	
Mouse Phenotype	increased incidence of corneal inflammation	199	2.881492e-8	0.0000013844193473366833	2.277454	57	0.003801774	252	0.008320596835714286	1.737976	19	21	0.001943734	
Mouse Phenotype	increased liver adenoma incidence	232	9.251248e-8	0.0000038125509537931036	2.179688	58	0.003868472	187	0.0016936580364705885	1.715108	25	28	0.002557545