# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	77	1.211636e-28	2.0706387174025975e-26	2.184595	254	0.01188193	446	0.00008754482069506727	1.319189	96	118	0.008290155	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	111	4.696695e-21	5.567910766216215e-19	2.131933	193	0.009028395	639	0.0017344583418466353	1.304252	74	92	0.006390328	
GO Biological Process	cotranslational protein targeting to membrane	121	1.999369e-19	2.1743550967768594e-17	2.038054	197	0.009215512	741	0.004611696746963562	1.274038	77	98	0.006649396	
GO Biological Process	adherens junction assembly	139	8.98287e-18	8.503999016546762e-16	2.105965	165	0.007718576	815	0.010027067582331288	1.430738	30	34	0.002590674	
GO Biological Process	pyrimidine nucleotide catabolic process	157	1.672781e-16	1.402046189745223e-14	4.537084	46	0.002151845	980	0.025000314135714286	1.621503	13	13	0.001122625	
GO Biological Process	pyrimidine deoxyribonucleotide catabolic process	174	8.390308e-16	6.345290975402299e-14	4.621168	43	0.002011508	1069	0.03717784327128157	1.621503	12	12	0.001036269	
GO Biological Process	axonal transport	255	3.52842e-12	1.820803089411765e-10	2.008877	121	0.005660289	645	0.0019350960309457363	1.455195	35	39	0.003022453	
GO Biological Process	regulation of hydrogen peroxide-induced cell death	257	3.546197e-12	1.8157356545914395e-10	2.00225	122	0.005707068	729	0.004074344093278464	1.551002	22	23	0.001899827	
GO Biological Process	ribosomal small subunit assembly	279	1.07406e-11	5.065790516129032e-10	3.396794	44	0.002058287	699	0.0031190820998569383	1.621503	18	18	0.001554404	
GO Biological Process	anterograde axonal transport	292	1.709139e-11	7.702246609931507e-10	2.259347	86	0.004023015	776	0.006683513755412372	1.464583	28	31	0.002417962	
GO Biological Process	anterograde synaptic vesicle transport	299	2.097526e-11	9.231218941137123e-10	2.965515	52	0.002432521	1080	0.037927771435185186	1.52612	16	17	0.001381693	
GO Biological Process	pyrimidine deoxyribonucleotide metabolic process	392	7.604959e-10	2.552899374515306e-8	2.425492	62	0.002900313	988	0.02692969371761134	1.531419	17	18	0.001468048	
GO Biological Process	cytokinetic process	451	3.58138e-9	1.0449529804878049e-7	2.307094	63	0.002947093	988	0.02692969371761134	1.531419	17	18	0.001468048	
GO Biological Process	clathrin coat assembly	483	1.187301e-8	3.2347192254658386e-7	2.068679	75	0.003508444	1080	0.037927771435185186	1.52612	16	17	0.001381693	
GO Cellular Component	PRC1 complex	61	2.364472e-15	6.698045272131148e-14	4.582819	42	0.001964728	207	0.025212296347826086	1.621503	12	12	0.001036269	
GO Cellular Component	nuclear ubiquitin ligase complex	66	8.60417e-15	2.2527281454545455e-13	2.441349	98	0.004584366	154	0.0034405007376623374	1.418815	35	40	0.003022453	
GO Cellular Component	axon cytoplasm	82	2.525801e-12	5.322663570731708e-11	2.013175	122	0.005707068	132	0.00084564432	1.459352	36	40	0.003108808	
GO Cellular Component	GATOR2 complex	261	0.0002271271	0.0015037380413793103	2.048668	31	0.001450157	214	0.039558958654205605	1.621503	11	11	0.0009499136	
GO Molecular Function	DNA N-glycosylase activity	29	7.893843e-14	1.1492346602068966e-11	3.953788	44	0.002058287	154	0.03146599027272728	1.621503	14	14	0.001208981	
GO Molecular Function	NF-kappaB binding	37	1.118593e-12	1.27640530972973e-10	2.346339	89	0.004163353	157	0.03366582462420382	1.44777	25	28	0.002158895	
Human Phenotype	Laryngomalacia	51	6.415581e-9	8.394347453529413e-7	2.342941	59	0.002759976	320	0.023933986540625	1.621503	14	14	0.001208981	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	3	8.299833e-23	2.5333856927e-19	2.865927	119	0.005566731	527	0.019395273155597727	1.486377	22	24	0.001899827	
Mouse Phenotype Single KO	increased integument system tumor incidence	7	2.218996e-21	2.9027637674285713e-18	2.04824	216	0.01010432	514	0.01743341905466926	1.280134	60	76	0.005181347	
Mouse Phenotype Single KO	enlarged liver sinusoidal spaces	9	8.170803e-21	8.313338119e-18	2.268488	166	0.007765355	653	0.04436810499693721	1.358556	31	37	0.002677029	
Mouse Phenotype Single KO	increased squamous cell carcinoma incidence	16	1.044509e-18	5.977855570625e-16	2.669321	108	0.005052159	451	0.010025869355875832	1.496772	24	26	0.002072539	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	22	1.641363e-17	6.831800450454546e-15	2.081057	167	0.007812135	484	0.013044135148347107	1.324227	49	60	0.004231434	
Mouse Phenotype Single KO	early cellular replicative senescence	31	3.321314e-16	9.810732999354838e-14	2.105598	149	0.006970108	506	0.016020996715810275	1.340858	43	52	0.003713299	
Mouse Phenotype Single KO	abnormal parathyroid gland morphology	154	9.86592e-9	5.866378535064935e-7	2.089971	74	0.003461664	553	0.02168978683363472	1.53616	18	19	0.001554404	
Mouse Phenotype	enlarged liver sinusoidal spaces	11	6.13894e-25	5.335855030909091e-22	2.28343	199	0.00930907	725	0.011189914823172413	1.38421	35	41	0.003022453	
Mouse Phenotype	abnormal cellular replicative senescence	14	9.117617e-23	6.226681152642856e-20	2.004657	244	0.01141414	373	0.00033722005857908847	1.351252	70	84	0.006044905	
Mouse Phenotype	early cellular replicative senescence	20	1.292658e-21	6.179551569e-19	2.042849	220	0.01029143	325	0.00009490963468615386	1.399379	63	73	0.005440415	
Mouse Phenotype	sacral vertebral transformation	100	4.209744e-12	4.0249362384e-10	3.063828	53	0.0024793	956	0.03702886290690377	1.467074	19	21	0.00164076	
Mouse Phenotype	small hair follicles	192	1.725444e-9	8.59217191875e-8	2.05742	85	0.003976236	754	0.014553782096816978	1.621503	14	14	0.001208981	
Mouse Phenotype	abnormal small intestinal microvillus morphology	313	1.225791e-7	0.000003744341134504792	2.563843	41	0.001917949	754	0.014553782096816978	1.621503	14	14	0.001208981	
Mouse Phenotype	increased kidney tumor incidence	599	0.00002258028	0.00036041745756260437	2.002547	44	0.002058287	636	0.006555980706603772	1.621503	16	16	0.001381693	
Mouse Phenotype	abnormal hematopoietic stem cell proliferation	1178	0.001890245	0.015341793247028862	2.029191	22	0.001029143	814	0.021868931679361176	1.621503	13	13	0.001122625