# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	16	8.914068e-28	7.33126380075e-25	2.044563	284	0.03142984	184	0.0000047457776164130426	1.430957	135	239	0.01821371	
GO Biological Process	negative regulation of gene expression, epigenetic	30	5.72588e-23	2.511561830666667e-20	2.697679	132	0.01460823	484	0.02353921342623967	1.377773	62	114	0.008364814	
GO Biological Process	multi-organism metabolic process	36	2.575356e-21	9.413641556666667e-19	2.302942	164	0.01814962	113	2.239540690619469e-8	1.654416	96	147	0.01295197	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	43	2.011802e-19	6.156581980930233e-17	2.523071	124	0.01372289	158	0.0000010320778598101265	1.653101	77	118	0.01038856	
GO Biological Process	viral gene expression	45	2.640746e-19	7.722128136444444e-17	2.432483	132	0.01460823	132	1.0100968027272726e-7	1.675585	84	127	0.01133297	
GO Biological Process	gene silencing	47	4.783174e-19	1.3391869503404253e-16	2.061664	186	0.02058433	406	0.010904779030541871	1.322958	94	180	0.01268214	
GO Biological Process	regulation of membrane permeability	48	1.084218e-18	2.9723384712500003e-16	2.371058	134	0.01482957	228	0.00011498553516666666	1.657607	53	81	0.007150567	
GO Biological Process	viral transcription	51	2.820116e-18	7.276452243921569e-16	2.446096	123	0.01361222	127	6.294293699055117e-8	1.726248	77	113	0.01038856	
GO Biological Process	mitochondrial membrane organization	55	5.549315e-18	1.327698837909091e-15	2.074955	172	0.01903497	314	0.0018626979385668787	1.450532	71	124	0.009579061	
GO Biological Process	regulation of mitochondrial membrane permeability	56	7.413887e-18	1.7421310541607145e-15	2.434567	121	0.01339088	221	0.00009388898865610859	1.700451	49	73	0.006610901	
GO Biological Process	positive regulation of mitochondrial membrane permeability	61	2.032153e-17	4.383787102786885e-15	3.832866	59	0.006529438	524	0.03430475962213741	1.899993	15	20	0.002023745	
GO Biological Process	translational elongation	64	3.191192e-17	6.5613899262500005e-15	2.416244	118	0.01305888	224	0.00010109284258928571	1.560709	69	112	0.009309228	
GO Biological Process	ribonucleoprotein complex export from nucleus	65	6.690192e-17	1.3544036388923078e-14	2.280008	130	0.0143869	170	0.000001855405841	1.621328	80	125	0.01079331	
GO Biological Process	positive regulation of membrane permeability	67	9.721923e-17	1.9094146978656717e-14	3.649017	60	0.006640106	543	0.039262651279926335	1.842418	16	22	0.002158662	
GO Biological Process	regulation of DNA-templated transcription in response to stress	68	1.026581e-16	1.9865852027941176e-14	2.125249	150	0.01660027	507	0.027548846660749506	1.36246	64	119	0.008634647	
GO Biological Process	ribonucleoprotein complex localization	72	1.832296e-16	3.348775425555555e-14	2.23322	132	0.01460823	172	0.000001889104509883721	1.615742	81	127	0.01092822	
GO Biological Process	RNA 3'-end processing	73	2.149352e-16	3.8744278038356166e-14	2.402475	113	0.01250553	163	0.00000129078245601227	1.680991	71	107	0.009579061	
GO Biological Process	termination of RNA polymerase II transcription	80	8.540844e-16	1.4048620774499998e-13	2.872616	79	0.008742807	201	0.000025608965583582088	1.762313	48	69	0.006475985	
GO Biological Process	DNA-templated transcription, termination	82	9.75896e-16	1.566075056585366e-13	2.338243	114	0.0126162	202	0.00002604909388069307	1.603664	69	109	0.009309228	
GO Biological Process	mRNA export from nucleus	86	1.556563e-15	2.3817223856976745e-13	2.331795	113	0.01250553	187	0.000005690515959251337	1.649051	69	106	0.009309228	
GO Cellular Component	ficolin-1-rich granule lumen	31	9.092379e-21	5.068268036129032e-19	2.357548	152	0.0168216	41	5.921173229268293e-7	1.634403	80	124	0.01079331	
GO Cellular Component	ribosomal subunit	39	2.735814e-16	1.2121760492307693e-14	2.038878	161	0.01781762	55	0.000004375198603636363	1.478914	108	185	0.01457097	
GO Cellular Component	mitochondrial ribosome	48	3.71741e-13	1.3382676000000002e-11	2.621523	75	0.008300133	127	0.014931784062992127	1.430583	48	85	0.006475985	
GO Cellular Component	nuclear chromosome, telomeric region	52	1.893405e-12	6.291930461538461e-11	2.038771	119	0.01316954	106	0.005052927939622642	1.381813	72	132	0.009713977	
GO Cellular Component	vesicle coat	55	3.454111e-11	1.0852188741818182e-9	2.247787	84	0.009296149	104	0.0038607673846153844	1.63921	33	51	0.00445224	
GO Cellular Component	intrinsic component of mitochondrial membrane	66	2.347846e-10	6.1470877090909095e-9	2.230771	78	0.008632138	91	0.0006769791296703297	1.636917	42	65	0.005666487	
GO Cellular Component	integral component of mitochondrial membrane	73	8.863123e-10	2.0980104854794522e-8	2.188727	76	0.008410801	96	0.00106493004	1.622911	41	64	0.00553157	
GO Cellular Component	granular component	74	1.121223e-9	2.6182072216216216e-8	7.526606	16	0.001770695	148	0.04411691416216216	2.533324	6	6	0.0008094981	
GO Cellular Component	intrinsic component of mitochondrial outer membrane	83	5.229786e-9	1.0888036395180723e-7	3.206281	35	0.003873395	145	0.0402285312	1.762313	16	23	0.002158662	
GO Cellular Component	mitochondrial nucleoid	89	1.597597e-8	3.1018512539325844e-7	2.502493	49	0.005422753	142	0.032824406535211265	1.568248	26	42	0.003507825	
GO Cellular Component	small ribosomal subunit	90	2.116666e-8	4.0639987200000005e-7	2.120744	68	0.007525454	152	0.046512212210526316	1.407402	40	72	0.005396654	
GO Cellular Component	pre-autophagosomal structure	101	8.632767e-8	0.0000014769724134653465	2.388232	48	0.005312085	139	0.030632802992805755	1.662494	21	32	0.002833243	
GO Cellular Component	small nuclear ribonucleoprotein complex	110	3.178941e-7	0.000004993827316363636	2.038339	62	0.006861443	112	0.00959597742857143	1.505309	41	69	0.00553157	
GO Cellular Component	spliceosomal snRNP complex	119	0.000001032493	0.000014992839529411765	2.09207	53	0.005865427	123	0.014148372292682928	1.511823	37	62	0.004991905	
GO Cellular Component	preribosome, large subunit precursor	165	0.00002698067	0.0002825611985454545	2.433902	28	0.003098716	146	0.04326631495890411	1.722661	17	25	0.002293578	
GO Cellular Component	spliceosomal tri-snRNP complex	206	0.0002014963	0.0016902213902912622	2.227548	26	0.002877379	151	0.04638968201324504	1.659764	19	29	0.002563411	
GO Cellular Component	nuclear pore outer ring	218	0.0003111956	0.002466724755963303	3.204292	13	0.00143869	133	0.01944263747368421	2.279992	9	10	0.001214247	
GO Molecular Function	unfolded protein binding	14	6.568539e-19	1.980883689857143e-16	2.600319	114	0.0126162	80	0.006451796525	1.457856	61	106	0.008229897	
GO Molecular Function	rRNA binding	16	3.251695e-16	8.58041018125e-14	3.462058	62	0.006861443	66	0.0011667976772727273	1.688883	40	60	0.005396654	
GO Molecular Function	ribonucleoprotein complex binding	20	6.281747e-13	1.3260767917000002e-10	2.067939	120	0.01328021	46	0.00010015804708695653	1.564052	71	115	0.009579061	
GO Molecular Function	peptidyl-prolyl cis-trans isomerase activity	24	1.258822e-11	2.214477701666667e-9	2.462772	73	0.008078796	105	0.039725529813333334	1.628566	27	42	0.003642742	
GO Molecular Function	snRNA binding	42	8.236543e-9	8.279686796666666e-7	2.978357	38	0.004205401	76	0.0043951881065789474	1.799994	27	38	0.003642742	
GO Molecular Function	clathrin adaptor activity	206	0.0003857206	0.007905399869902912	2.415236	20	0.002213369	99	0.027537666622222217	2.303022	10	11	0.001349164	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	132	7.890871e-8	0.000005473992859621212	2.506925	44	0.004869411	75	0.010575735521733333	2.005548	19	24	0.002563411	
Mouse Phenotype Single KO	increased cellular sensitivity to DNA damaging agents	347	0.0001636943	0.004319736902305476	2.585589	20	0.002213369	96	0.026379170828124996	2.322214	11	12	0.00148408	
Mouse Phenotype	abnormal DNA repair	56	1.033052e-12	1.7637518164285716e-10	2.03796	122	0.01350155	206	0.033734498654854374	1.370487	66	122	0.008904479	
Mouse Phenotype	early cellular replicative senescence	89	4.078395e-10	4.381296021910113e-8	2.042994	93	0.01029216	198	0.028951828278787877	1.492232	43	73	0.005801403	
Mouse Phenotype	increased leiomyosarcoma incidence	104	3.835437e-9	3.5260204958653844e-7	5.610355	19	0.0021027	164	0.013525859251829269	2.533324	9	9	0.001214247	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	112	9.598327e-9	8.193714682767856e-7	2.741828	43	0.004758743	153	0.010942826958823529	1.857771	22	30	0.00296816	
Mouse Phenotype	increased fibroblast apoptosis	159	2.261067e-7	0.000013596265149056602	2.059672	62	0.006861443	186	0.019321644988709676	1.636105	31	48	0.004182407