# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	7	1.633153e-31	3.0700943324285717e-28	2.130552	296	0.02209945	275	0.00004703959692727273	1.383371	107	155	0.01141942	
GO Biological Process	regulation of necrotic cell death	10	6.02444e-28	7.927560596e-25	5.125082	72	0.005375541	809	0.046446260145859085	1.558627	21	27	0.002241195	
GO Biological Process	regulation of mitochondrial membrane permeability	67	3.913482e-17	7.68619546835821e-15	2.117517	156	0.01164701	472	0.004732974476694915	1.42747	52	73	0.005549626	
GO Biological Process	hemidesmosome assembly	83	2.628325e-16	4.167003454819277e-14	4.778857	43	0.003210393	562	0.011154650154092527	2.003949	11	11	0.001173959	
GO Biological Process	maintenance of protein location in cell	92	9.449096e-16	1.3515288506956523e-13	2.053183	153	0.01142303	446	0.002960078694170404	1.417427	58	82	0.006189968	
GO Biological Process	actin filament bundle organization	133	9.625317e-14	9.523274165639098e-12	2.024059	136	0.0101538	619	0.01768121046042003	1.453845	37	51	0.003948773	
GO Biological Process	positive regulation of mRNA catabolic process	141	1.545857e-13	1.4426902314184395e-11	2.52588	83	0.006196805	551	0.010427697899092559	1.683317	21	25	0.002241195	
GO Biological Process	negative regulation of Notch signaling pathway	152	3.370224e-13	2.917682737894737e-11	2.385615	90	0.006719427	378	0.0010850629421428571	1.70032	28	33	0.00298826	
GO Biological Process	virion assembly	174	1.995012e-12	1.5087564889655172e-10	2.673084	68	0.0050769	462	0.004203705211904761	1.614292	29	36	0.003094984	
GO Biological Process	maintenance of protein localization in organelle	221	1.715486e-11	1.0214515961085974e-9	2.844291	56	0.004180977	716	0.029300700540502794	1.551444	24	31	0.002561366	
GO Biological Process	regulation of mRNA catabolic process	231	2.322265e-11	1.3228868023809523e-9	2.145715	95	0.007092728	354	0.0005944749242655367	1.745375	27	31	0.002881537	
GO Biological Process	positive regulation of intrinsic apoptotic signaling pathway	233	2.718294e-11	1.5351944526180257e-9	2.092963	100	0.00746603	498	0.006587583008232931	1.484406	40	54	0.004268943	
GO Biological Process	pyrimidine deoxyribonucleotide catabolic process	303	7.382819e-10	3.206287631056106e-8	4.459572	26	0.001941168	825	0.04949833613939394	1.836953	11	12	0.001173959	
GO Biological Process	pyrimidine nucleotide catabolic process	312	9.716426e-10	4.098027235064102e-8	4.250296	27	0.002015828	728	0.030129193450549454	1.849799	12	13	0.001280683	
GO Biological Process	deoxyribonucleotide catabolic process	446	6.335153e-8	0.0000018691542225784752	2.84017	36	0.002687771	769	0.036716758577373214	1.687536	16	19	0.001707577	
GO Biological Process	cellular response to electrical stimulus	451	6.852924e-8	0.0000019995039227494456	3.191398	30	0.002239809	825	0.04949833613939394	1.836953	11	12	0.001173959	
GO Biological Process	multi-organism membrane organization	468	1.006592e-7	0.0000028302872068376065	2.245351	54	0.004031656	716	0.029300700540502794	1.551444	24	31	0.002561366	
GO Biological Process	deoxyribose phosphate catabolic process	474	1.116691e-7	0.0000031001132635021094	2.727999	37	0.002762431	682	0.024045332649560117	1.703356	17	20	0.001814301	
GO Biological Process	viral budding via host ESCRT complex	544	5.488629e-7	0.000013276630332904412	2.478422	39	0.002911752	682	0.024045332649560117	1.703356	17	20	0.001814301	
GO Biological Process	synaptic vesicle maturation	593	0.000001378774	0.00003059576233726812	3.094128	25	0.001866507	749	0.03364536690520695	2.003949	9	9	0.0009605123	
GO Cellular Component	platelet dense tubular network membrane	161	0.000001093296	0.000011734257689440995	2.845093	29	0.002165149	162	0.020427392	2.003949	9	9	0.0009605123	
GO Cellular Component	laminin complex	167	0.000001836849	0.000019006437556886225	2.829218	28	0.002090488	182	0.03645264421978022	2.003949	8	8	0.0008537887	
GO Cellular Component	telomerase holoenzyme complex	296	0.0005266083	0.0030742538594594596	2.054473	27	0.002015828	122	0.005828048262295082	1.730683	19	22	0.002027748	
Human Phenotype	Nail dystrophy	1	2.000849e-23	1.3351665377e-19	2.490922	156	0.01164701	146	0.01930996632671233	1.414552	48	68	0.005122732	
Human Phenotype	Foot dorsiflexor weakness	65	4.651114e-10	4.774905188e-8	2.039187	93	0.006943407	189	0.0372384116984127	1.502962	30	40	0.003201708	
Human Phenotype	Onion bulb formation	86	1.800075e-9	1.396732613372093e-7	2.280747	67	0.00500224	147	0.01982078920272109	1.683317	21	25	0.002241195	
Human Phenotype	Heat intolerance	213	3.992939e-7	0.000012509334247417841	2.813929	32	0.002389129	180	0.035410904727777776	2.003949	10	10	0.001067236	
Mouse Phenotype Single KO	abnormal thymus development	56	3.222958e-12	5.270111858214285e-10	2.847435	60	0.004479618	310	0.007415356323225807	1.878702	15	16	0.001600854	
Mouse Phenotype Single KO	increased body temperature	76	1.993277e-11	2.4016365117105263e-9	2.275695	84	0.006271465	513	0.03892351531578947	1.518143	25	33	0.00266809	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	78	2.038748e-11	2.3934378764102566e-9	2.141347	96	0.007167388	415	0.01974265307493976	1.545903	27	35	0.002881537	
Mouse Phenotype Single KO	absent ductus venosus valve	137	1.954181e-9	1.3061631691240877e-7	2.260082	68	0.0050769	509	0.03778066660903733	1.639594	18	22	0.001921025	
Mouse Phenotype Single KO	microcytosis	212	8.26873e-8	0.0000035715453117924524	2.567842	42	0.003135732	399	0.016489239398746865	1.71767	18	21	0.001921025	
Mouse Phenotype Single KO	decreased spongiotrophoblast size	237	2.231164e-7	0.000008620577530801688	2.412589	44	0.003285053	386	0.015059388694818654	1.781288	16	18	0.001707577	
Mouse Phenotype Single KO	excessive folding of visceral yolk sac	545	0.00008765021	0.0014726843540733944	2.107527	33	0.00246379	266	0.004078806640977444	2.003949	13	13	0.001387407	
Mouse Phenotype	increased body temperature	33	1.743576e-16	5.051615192727273e-14	2.469964	108	0.008063312	578	0.014800482587024221	1.545903	27	35	0.002881537	
Mouse Phenotype	increased incidence of corneal inflammation	82	4.175619e-12	4.868669909634146e-10	2.772966	62	0.004628938	550	0.012489956722363636	1.71767	18	21	0.001921025	
Mouse Phenotype	absent ductus venosus valve	169	1.954181e-9	1.1055576651479289e-7	2.260082	68	0.0050769	678	0.02961473214159292	1.639594	18	22	0.001921025	
Mouse Phenotype	dry eyes	213	3.495956e-8	0.0000015692410946478876	2.245449	58	0.004330297	673	0.028883667347696883	1.753455	14	16	0.00149413	
Mouse Phenotype	decreased spongiotrophoblast size	231	5.97472e-8	0.00000247291332987013	2.474329	46	0.003434374	476	0.0070605835783613445	1.793007	17	19	0.001814301	
Mouse Phenotype	microcytosis	268	1.974223e-7	0.000007043114217537313	2.423759	44	0.003285053	771	0.03962612873540856	1.586459	19	24	0.002027748	
Mouse Phenotype	abnormal spongiotrophoblast size	297	3.718247e-7	0.000011969750695959597	2.042981	61	0.004554278	654	0.026133984770642205	1.574531	22	28	0.002347919	
Mouse Phenotype	fused dorsal root ganglion	311	6.08112e-7	0.000018695044475884245	2.114903	54	0.004031656	797	0.04396013442158093	1.669957	15	18	0.001600854	
Mouse Phenotype	abnormal sebocyte number	403	0.000003797883	0.00009010312497022333	3.08123	23	0.001717187	809	0.045374461435105075	2.003949	8	8	0.0008537887