# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 136 7.652789e-21 7.404636062573529e-19 2.190833 179 0.01191586 481 0.0006638047974844074 1.357023 84 118 0.008527919 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 143 5.066411e-20 4.662161003426573e-18 2.014841 209 0.01391293 702 0.009281275138176639 1.298979 77 113 0.007817259 GO Biological Process heterochromatin organization 162 9.991771e-18 8.116155221543209e-16 3.898708 59 0.003927573 972 0.0393126072664609 1.759656 12 13 0.001218274 GO Biological Process cotranslational protein targeting to membrane 190 1.224537e-15 8.480885464736843e-14 2.105254 143 0.009519372 552 0.002263732757717391 1.361639 70 98 0.007106599 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 193 1.933301e-15 1.31815066626943e-13 2.137835 136 0.009053388 638 0.0057446872648902825 1.346838 65 92 0.006598985 GO Biological Process placenta blood vessel development 247 8.930425e-13 4.7577110354251016e-11 2.19864 103 0.00685661 807 0.017900512190830237 1.537334 25 31 0.002538071 GO Biological Process response to laminar fluid shear stress 341 2.850775e-10 1.1000981884164222e-8 2.339749 70 0.004659832 876 0.024492083598173515 1.770131 13 14 0.001319797 GO Biological Process cytoplasmic translation 381 1.145184e-9 3.955243111811024e-8 2.378747 63 0.004193849 956 0.03641914296338912 1.418638 32 43 0.003248731 GO Biological Process intra-S DNA damage checkpoint 441 8.329095e-9 2.485318845918367e-7 3.434522 31 0.00206364 1015 0.048473036910344824 1.668008 14 16 0.00142132 GO Biological Process metanephric tubule morphogenesis 450 1.193348e-8 3.489614740444444e-7 2.380767 55 0.003661297 871 0.02378817847301952 1.906294 10 10 0.001015228 GO Biological Process viral translation 685 8.441918e-7 0.00001621710933751825 3.623772 21 0.00139795 972 0.0393126072664609 1.759656 12 13 0.001218274 GO Biological Process terpenoid biosynthetic process 1461 0.0003845516 0.003463596512251882 2.037281 29 0.001930502 764 0.014219563728534031 1.906294 11 11 0.001116751 GO Cellular Component COP9 signalosome 98 2.462491e-10 4.342024946938775e-9 2.217478 79 0.005258954 162 0.03755601066666667 1.457755 26 34 0.002639594 GO Cellular Component precatalytic spliceosome 151 5.504478e-7 0.000006299164227814569 2.414701 41 0.00272933 96 0.0042254514 1.633967 24 28 0.002436548 GO Molecular Function snRNA binding 54 1.446126e-12 1.1306562911111111e-10 2.875885 61 0.004060711 82 0.0004143387904634146 1.655466 33 38 0.003350254 GO Molecular Function AMP binding 296 0.0001556885 0.0022206650236486487 2.3096 25 0.001664226 122 0.028570322449180327 1.906294 11 11 0.001116751 Human Phenotype Glioma 587 0.0004831085 0.005491964259795571 2.099732 26 0.001730795 226 0.0269105496079646 1.779208 14 15 0.00142132 Mouse Phenotype Single KO abnormal liver sinusoid morphology 34 4.930083e-18 1.3277873538529413e-15 2.081759 172 0.01144987 523 0.025326493630975142 1.357513 47 66 0.004771574 Mouse Phenotype Single KO abnormal cellular replicative senescence 73 5.047825e-13 6.331908702054795e-11 2.092514 118 0.007855146 388 0.006628823101546393 1.429721 45 60 0.004568528 Mouse Phenotype Single KO increased squamous cell carcinoma incidence 78 7.749688e-13 9.097935002051282e-11 2.602722 74 0.004926108 603 0.04116074537147595 1.539699 21 26 0.00213198 Mouse Phenotype Single KO small basisphenoid bone 147 2.668895e-10 1.6625218717687074e-8 2.213445 79 0.005258954 615 0.043236778128455285 1.759656 12 13 0.001218274 Mouse Phenotype Single KO increased hemangiosarcoma incidence 181 1.395446e-9 7.059723216574586e-8 2.296212 67 0.004460125 545 0.028115333565137613 1.588579 20 24 0.002030457 Mouse Phenotype Single KO increased embryonic neuroepithelium apoptosis 287 1.473662e-7 0.000004701854680836237 2.277508 51 0.003395021 390 0.006611471397435897 1.794159 16 17 0.001624365 Mouse Phenotype Single KO uveal coloboma 435 0.000008094959 0.00017040353922528737 2.018793 48 0.003195314 471 0.01605051791464968 1.906294 11 11 0.001116751 Mouse Phenotype Single KO decreased fetal cardiomyocyte proliferation 596 0.00004716053 0.0007245788141107383 2.098887 36 0.002396485 627 0.04385518050558213 1.906294 9 9 0.0009137056 Mouse Phenotype Single KO lethality during fetal growth through weaning, incomplete penetrance 735 0.0001732956 0.002159003822040816 2.292952 25 0.001664226 627 0.04385518050558213 1.906294 9 9 0.0009137056 Mouse Phenotype abnormal cellular replicative senescence 53 5.903234e-22 1.0649211372452831e-19 2.197997 188 0.01251498 445 0.00103536069 1.407027 62 84 0.006294416 Mouse Phenotype early cellular replicative senescence 57 1.501561e-20 2.5186710036842106e-18 2.233157 169 0.01125017 624 0.00520299660625 1.384022 53 73 0.005380711 Mouse Phenotype enlarged liver sinusoidal spaces 138 5.44876e-13 3.775043069565217e-11 2.041097 125 0.008321129 1100 0.047461169056363633 1.39485 30 41 0.003045685 Mouse Phenotype lethality during fetal growth through weaning, incomplete penetrance 144 1.069213e-12 7.099128814583332e-11 3.062878 56 0.003727866 913 0.02305573888389923 1.682024 15 17 0.001522843 Mouse Phenotype abnormal third pharyngeal arch morphology 153 1.780025e-12 1.112341112745098e-10 2.050514 118 0.007855146 1042 0.037188674804222645 1.497803 22 28 0.002233503 Mouse Phenotype small basisphenoid bone 213 3.558523e-10 1.597325746619718e-8 2.129383 85 0.005658368 913 0.02305573888389923 1.682024 15 17 0.001522843 Mouse Phenotype absent stapedial artery 344 4.308097e-8 0.0000011973754481686047 2.231517 58 0.003861004 723 0.009910218500414937 1.705632 17 19 0.001725888 Mouse Phenotype abnormal stapedial artery morphology 364 8.386172e-8 0.000002202752486043956 2.186334 58 0.003861004 954 0.025438804374213836 1.62035 17 20 0.001725888 Mouse Phenotype increased embryonic neuroepithelium apoptosis 460 6.879226e-7 0.000014298321692608696 2.03077 59 0.003927573 773 0.012783737278137128 1.601287 21 25 0.00213198 Mouse Phenotype abnormal sublingual gland morphology 631 0.000008786188 0.0001331295459080824 2.172138 40 0.002662761 648 0.0063865207787037045 1.906294 12 12 0.001218274 Mouse Phenotype abnormal mismatch repair 687 0.00001621444 0.00022565685711790394 2.73683 24 0.001597657 985 0.02914756753401015 1.906294 9 9 0.0009137056 Mouse Phenotype decreased embryonic epiblast cell proliferation 942 0.0001579963 0.0016036121277070066 2.092961 31 0.00206364 1116 0.04906052379032259 1.906294 8 8 0.0008121827 Mouse Phenotype increased fibroma incidence 1174 0.0006498238 0.005292134030494037 2.167844 23 0.001531088 985 0.02914756753401015 1.906294 9 9 0.0009137056