# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	31	4.91865e-75	2.087887591935484e-72	2.486507	530	0.01716988	394	0.00004416694775634518	1.267405	101	113	0.007627247	
GO Biological Process	regulation of DNA-templated transcription in response to stress	40	1.500608e-70	4.936625168e-68	2.335042	563	0.01823895	344	0.00001159820871482558	1.274998	107	119	0.00808035	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	51	1.80962e-63	4.669174427450981e-61	2.06757	662	0.02144616	455	0.0001782309042043956	1.216725	133	155	0.0100438	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	2.247776e-63	5.6881700738461544e-61	2.036381	686	0.02222366	172	1.7589245120348837e-10	1.28908	180	198	0.01359311	
GO Biological Process	endoplasmic reticulum unfolded protein response	59	2.762988e-60	6.162399846101695e-58	2.34572	475	0.0153881	602	0.0019143186402823921	1.218972	98	114	0.007400695	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	70	1.354642e-56	2.5465334397142857e-54	2.299021	464	0.01503175	621	0.0023037615987117556	1.236968	82	94	0.006192418	
GO Biological Process	cellular response to topologically incorrect protein	82	2.344273e-51	3.761986391097561e-49	2.082162	524	0.01697551	713	0.005659743113043478	1.183357	116	139	0.008760006	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	84	6.25979e-51	9.806259120238096e-49	3.772743	189	0.006122846	983	0.03366551439267548	1.358905	23	24	0.001736898	
GO Biological Process	cellular response to unfolded protein	86	1.104414e-50	1.689881840232558e-48	2.137493	486	0.01574446	575	0.0012418205513043477	1.218767	104	121	0.007853799	
GO Biological Process	IRE1-mediated unfolded protein response	91	9.317132e-50	1.3472982416263739e-47	2.938081	261	0.008455358	891	0.022331280832772166	1.246852	51	58	0.003851382	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	93	3.415001e-49	4.832042812795699e-47	2.328907	391	0.01266684	233	5.34469332583691e-8	1.321853	110	118	0.008306902	
GO Biological Process	regulation of necrotic cell death	120	1.512324e-42	1.658389293e-40	4.231464	137	0.004438253	835	0.01545830122467066	1.36547	26	27	0.00196345	
GO Biological Process	liver regeneration	129	8.873425e-42	9.051581362403101e-40	2.745362	243	0.00787223	778	0.00985364186992288	1.33696	33	35	0.002492071	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	136	7.96462e-41	7.706355483823529e-39	2.282463	336	0.01088506	746	0.007784123544772118	1.236195	68	78	0.005135176	
GO Biological Process	regulation of mitochondrial membrane permeability	168	2.800409e-38	2.193487025654762e-36	2.138015	363	0.01175975	554	0.0009340289078519856	1.282017	66	73	0.004984141	
GO Biological Process	cotranslational protein targeting to membrane	181	4.362171e-36	3.171370618176795e-34	2.228169	311	0.01007516	208	9.775308658173077e-9	1.360111	94	98	0.007098626	
GO Biological Process	translational elongation	188	1.958749e-35	1.3710201112234041e-33	2.097947	350	0.0113386	292	0.0000011540393428424658	1.304043	103	112	0.007778281	
GO Biological Process	viral gene expression	199	7.76493e-34	5.134608737185929e-32	2.006719	372	0.01205132	167	1.1819768383832333e-10	1.350997	121	127	0.009137593	
GO Biological Process	mitochondrial transmembrane transport	209	6.488833e-33	4.085481026172248e-31	2.14643	307	0.009945575	643	0.0029385725130637638	1.247146	73	83	0.005512762	
GO Biological Process	mitochondrial translational termination	215	1.51927e-32	9.298639037209302e-31	2.286108	264	0.008552546	299	0.000001455572002541806	1.336495	82	87	0.006192418	
GO Cellular Component	mitochondrial ribosome	55	1.074363e-33	3.375453207272727e-32	2.445446	239	0.007742646	104	0.0001203585563076923	1.284531	77	85	0.005814832	
GO Cellular Component	large ribosomal subunit	62	9.517437e-30	2.652601796129032e-28	2.003635	326	0.0105611	61	6.2512128e-8	1.319346	107	115	0.00808035	
GO Cellular Component	mitochondrial large ribosomal subunit	93	1.039577e-22	1.931601135483871e-21	2.530573	147	0.004762213	184	0.023147217391304348	1.251166	45	51	0.003398278	
GO Cellular Component	nuclear ubiquitin ligase complex	116	3.091637e-19	4.605473048275862e-18	2.38079	138	0.004470649	130	0.0017336479015384616	1.347089	38	40	0.002869657	
GO Cellular Component	DNA-directed RNA polymerase III complex	126	4.924522e-18	6.753630171428572e-17	3.754698	63	0.002040949	169	0.013372807952662722	1.417988	19	19	0.001434829	
GO Cellular Component	mitochondrial small ribosomal subunit	173	1.240074e-11	1.2386403884393065e-10	2.327347	82	0.002656473	161	0.007673114236024845	1.367346	27	28	0.002038967	
GO Cellular Component	spliceosomal tri-snRNP complex	177	1.446965e-11	1.4126302372881357e-10	2.232089	89	0.002883245	153	0.005878335247058823	1.369092	28	29	0.002114484	
GO Molecular Function	unfolded protein binding	11	3.761243e-47	1.4436334496363636e-44	2.383734	357	0.01156538	111	0.006610796189189189	1.21733	91	106	0.006872074	
GO Molecular Function	rRNA binding	30	1.007989e-24	1.4185765193333332e-22	2.566315	157	0.005086173	99	0.0028981420036363636	1.299823	55	60	0.004153451	
GO Molecular Function	snRNA binding	43	1.001462e-20	9.83295945116279e-19	2.707341	118	0.003822729	150	0.036354234666666665	1.306042	35	38	0.002643105	
GO Molecular Function	mRNA 5'-UTR binding	60	2.083762e-17	1.4662738606666667e-15	2.56751	107	0.003466373	124	0.015597807872580645	1.417988	22	22	0.00166138	
GO Molecular Function	NF-kappaB binding	63	5.433144e-17	3.641068883809524e-15	2.31869	127	0.004114293	130	0.023218206984615384	1.367346	27	28	0.002038967	
Human Phenotype	Abnormality of transition element cation homeostasis	17	2.312977e-26	9.07911501235294e-24	3.314654	112	0.003628353	224	0.015505120646428571	1.369092	28	29	0.002114484	
Human Phenotype	Abnormal CSF metabolite level	21	9.083522e-26	2.8863972526666667e-23	2.280638	207	0.006705974	183	0.0047098362180327865	1.282942	57	63	0.004304486	
Human Phenotype	Increased CSF lactate	44	3.567713e-20	5.410761102045454e-18	2.16553	178	0.00576649	219	0.013872353442465754	1.2713	52	58	0.003926899	
Mouse Phenotype	increased adrenal gland tumor incidence	465	8.002865e-14	1.6454923067741936e-12	2.56133	83	0.002688869	514	0.048954198717898835	1.417988	17	17	0.001283794