# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	3	2.108269e-39	9.247570590333334e-36	2.968493	200	0.0204981	325	0.0038296321884000004	1.457016	64	113	0.008768324	
GO Biological Process	regulation of DNA-templated transcription in response to stress	8	3.515356e-34	5.7823212005e-31	2.676756	204	0.02090807	318	0.003477170161037736	1.448407	67	119	0.00917934	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	16	1.016568e-30	8.360636445e-28	2.331881	236	0.02418776	145	0.000001121421777724138	1.576721	95	155	0.01301548	
GO Biological Process	positive regulation of nuclease activity	18	5.765488e-30	4.214892032888889e-27	6.596327	62	0.006354412	494	0.03809445259514171	2.058035	12	15	0.001644061	
GO Biological Process	mRNA catabolic process	19	7.659413e-30	5.304748193e-27	2.199506	259	0.02654504	122	3.541470883934426e-7	1.509709	125	213	0.01712563	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	21	1.748351e-29	1.0955500385238095e-26	7.914011	53	0.005431998	356	0.00746787665758427	2.572544	9	9	0.001233046	
GO Biological Process	nuclear-transcribed mRNA catabolic process	22	7.982344e-29	4.7745302134545455e-26	2.244528	239	0.02449523	158	0.000002557921376329114	1.494154	115	198	0.01575558	
GO Biological Process	RNA catabolic process	23	9.826004e-29	5.621755940695653e-26	2.073202	285	0.0292098	99	2.5870368037373738e-8	1.515773	142	241	0.01945472	
GO Biological Process	regulation of mRNA stability	29	1.715763e-26	7.785422523103448e-24	2.163486	237	0.02429025	188	0.00003079805154468085	1.516268	89	151	0.01219345	
GO Biological Process	endoplasmic reticulum unfolded protein response	36	5.265285e-25	1.9246079254166666e-22	2.530986	162	0.01660346	447	0.03059602917002237	1.376537	61	114	0.008357309	
GO Biological Process	regulation of nuclease activity	37	6.966098e-25	2.4774833400540545e-22	4.528706	72	0.007379317	389	0.014259721596401029	1.879936	19	26	0.002603096	
GO Biological Process	regulation of RNA stability	39	2.087851e-24	7.044623412564102e-22	2.0691	241	0.02470022	192	0.000040459552373958334	1.495291	93	160	0.01274147	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	41	2.327623e-24	7.470534404146341e-22	2.815321	131	0.01342626	260	0.0007881329992307692	1.616085	49	78	0.006713248	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	42	2.494574e-24	7.815737920476191e-22	2.508055	160	0.01639848	241	0.0003306199296016598	1.587314	58	94	0.007946294	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	53	1.535894e-22	3.8133639898113206e-20	2.600439	138	0.01414369	196	0.0000593887355494898	1.569688	72	118	0.009864365	
GO Biological Process	cellular response to topologically incorrect protein	56	4.43486e-22	1.0421129060714286e-19	2.250238	179	0.0183458	421	0.022650486679097387	1.351048	73	139	0.01000137	
GO Biological Process	cellular response to unfolded protein	62	2.709471e-21	5.750633691774194e-19	2.295856	165	0.01691094	465	0.03330981533333333	1.360685	64	121	0.008768324	
GO Biological Process	regulation of cellular amino acid metabolic process	65	5.627432e-21	1.1392519644307692e-18	3.378849	85	0.008711694	515	0.04442636819029126	1.500651	35	60	0.004795177	
GO Biological Process	translational elongation	70	2.768413e-20	5.2042209524285714e-18	2.503183	132	0.01352875	198	0.00005945912758686869	1.584871	69	112	0.00945335	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	75	5.993807e-20	1.0516334175066669e-17	3.393881	80	0.008199242	275	0.0010644769683636364	2.125145	19	23	0.002603096	
GO Cellular Component	ribosomal subunit	36	7.871698e-22	3.7784150400000003e-20	2.193143	187	0.01916573	53	0.000004013416935849056	1.487904	107	185	0.01465954	
GO Cellular Component	mitochondrial ribosome	40	1.454513e-19	6.283496160000001e-18	3.010477	93	0.009531618	78	0.00021559177107692307	1.604057	53	85	0.007261269	
GO Cellular Component	catalytic step 2 spliceosome	43	9.569947e-18	3.845783352558139e-16	2.358675	128	0.01311879	60	0.000024133409279999998	1.634637	61	96	0.008357309	
GO Cellular Component	ficolin-1-rich granule lumen	45	7.554808e-16	2.901046272e-14	2.097151	146	0.01496362	104	0.0036229198153846158	1.41075	68	124	0.009316345	
GO Cellular Component	mitochondrial large ribosomal subunit	49	1.137746e-14	4.012296097959184e-13	3.267721	60	0.006149431	85	0.001085272026352941	1.715029	34	51	0.004658172	
GO Cellular Component	spliceosomal snRNP complex	50	1.570324e-14	5.427039744e-13	2.778266	76	0.007789279	62	0.00003074599741935484	1.784184	43	62	0.005891218	
GO Cellular Component	endopeptidase complex	51	2.215347e-14	7.506116894117647e-13	2.522151	89	0.009121656	153	0.024736263529411762	1.454047	39	69	0.005343198	
GO Cellular Component	large ribosomal subunit	52	3.195101e-14	1.0617566400000001e-12	2.216655	114	0.01168392	76	0.00018888995368421054	1.521157	68	115	0.009316345	
GO Cellular Component	proteasome complex	53	5.48914e-14	1.7896667773584908e-12	2.495221	88	0.009019166	163	0.03449333948466258	1.437598	38	68	0.005206193	
GO Cellular Component	peptidase complex	56	3.531782e-13	1.0898070171428571e-11	2.203087	106	0.010864	135	0.0128376064	1.432439	49	88	0.006713248	
GO Cellular Component	PRC1 complex	59	3.946305e-12	1.155799159322034e-10	5.976595	25	0.002562263	151	0.024865874225165566	2.143787	10	12	0.001370051	
GO Cellular Component	small nuclear ribonucleoprotein complex	61	5.809851e-12	1.6458069718032785e-10	2.405313	79	0.008096751	75	0.00019134026495999998	1.677746	45	69	0.006165228	
GO Cellular Component	methyltransferase complex	68	1.994565e-11	5.068541647058823e-10	2.001412	113	0.01158143	71	0.00009000129802816902	1.611374	57	91	0.007809289	
GO Cellular Component	nuclear ubiquitin ligase complex	76	7.532837e-10	1.7127292547368422e-8	2.729004	50	0.005124526	150	0.02412652032	1.60784	25	40	0.003425127	
GO Cellular Component	small ribosomal subunit	77	7.894408e-10	1.7716281849350646e-8	2.195093	76	0.007789279	161	0.03186401947826087	1.429191	40	72	0.005480203	
GO Cellular Component	endoribonuclease complex	80	1.049678e-9	2.26730448e-8	2.920396	44	0.004509583	87	0.0011248314703448275	1.951585	22	29	0.003014112	
GO Cellular Component	PcG protein complex	85	2.471202e-9	5.0238083011764705e-8	2.058283	83	0.008506713	73	0.00014683907243835618	1.845521	33	46	0.004521167	
GO Cellular Component	spliceosomal tri-snRNP complex	89	6.018635e-9	1.1685619415730338e-7	3.015069	38	0.00389464	106	0.004181887154716981	1.862877	21	29	0.002877106	
GO Cellular Component	mitochondrial nucleoid	100	2.593304e-8	4.4812293120000005e-7	2.412164	51	0.005227017	105	0.003998068662857143	1.715029	28	42	0.003836142	
GO Cellular Component	U2-type prespliceosome	136	0.000002756971	0.00003502974917647059	3.142727	23	0.002357282	169	0.03774402915976331	1.929408	12	16	0.001644061	
GO Molecular Function	ribonucleoprotein complex binding	10	5.134842e-17	2.1679302924e-14	2.218356	139	0.01424618	24	0.000013479348949166667	1.633006	73	115	0.01000137	
GO Molecular Function	structural constituent of ribosome	11	6.197906e-17	2.3788690119999998e-14	2.070463	162	0.01660346	46	0.000521381113	1.445071	91	162	0.01246746	
GO Molecular Function	unfolded protein binding	12	1.950482e-15	6.862445836666668e-13	2.344794	111	0.01137645	75	0.018494144498666668	1.431888	59	106	0.008083299	
GO Molecular Function	ribonuclease activity	15	1.038344e-12	2.922592245333334e-10	2.08845	115	0.01178641	53	0.001845470453962264	1.533132	59	99	0.008083299	
GO Molecular Function	endoribonuclease activity	29	5.492092e-10	7.995728422068965e-8	2.300691	70	0.007174336	74	0.01648969423783784	1.60784	35	56	0.004795177	
GO Molecular Function	snRNA binding	47	1.998476e-8	0.0000017952267387234042	2.830855	39	0.00399713	69	0.01306500347536232	1.760162	26	38	0.003562132	
GO Molecular Function	telomerase RNA binding	160	0.00002543692	0.0006712167264999999	2.220798	34	0.003484678	72	0.016618319750000003	1.987875	17	22	0.002329086	
Human Phenotype	Increased serum lactate	4	4.088829e-23	6.82118897925e-20	2.64058	138	0.01414369	13	4.865694946153847e-7	1.775055	69	100	0.00945335	
Human Phenotype	Abnormality of mitochondrial metabolism	16	1.852826e-12	7.727442436250001e-10	2.272016	93	0.009531618	125	0.0229112597056	1.528613	41	69	0.005617208	
Human Phenotype	Abnormality of the mitochondrion	18	6.262906e-12	2.3217984298888888e-9	2.219984	93	0.009531618	152	0.04231675486776316	1.485554	41	71	0.005617208	
Human Phenotype	Increased CSF lactate	28	5.44349e-10	1.2973003132142856e-7	2.424805	63	0.006456903	118	0.01637879932881356	1.596752	36	58	0.004932182	
Human Phenotype	Abnormal CSF metabolite level	33	7.047826e-10	1.4251558453939395e-7	2.335355	67	0.006866865	109	0.01087908985229358	1.592527	39	63	0.005343198	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	54	4.34196e-8	0.000005365536866666666	3.341161	29	0.002972225	74	0.001539395271756757	2.401041	14	15	0.001918071	
Human Phenotype	Increased intramyocellular lipid droplets	61	9.099641e-8	0.000009954410556229507	3.492745	26	0.002664754	83	0.0030691731881927714	2.269892	15	17	0.002055076	
Human Phenotype	Increased muscle lipid content	69	1.830226e-7	0.00001770014217101449	3.365347	26	0.002664754	126	0.02346314714126984	2.030956	15	19	0.002055076	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	76	3.943845e-7	0.00003462799695394737	2.996605	29	0.002972225	96	0.006061452915	2.250976	14	16	0.001918071	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	113	0.000002834958	0.00016741305074336284	3.236729	22	0.002254791	149	0.040789030475167784	2.000868	14	18	0.001918071	
Human Phenotype	Ependymoma	317	0.0003572021	0.00751927322807571	3.345807	12	0.001229886	130	0.026696609503076923	2.572544	8	8	0.001096041	
Mouse Phenotype	decreased red blood cell distribution width	485	0.0008984289	0.017711090129690722	2.251857	20	0.00204981	192	0.0492032016359375	2.176768	11	13	0.001507056