# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 75 1.485902e-11 2.6070645890666667e-9 4.026534 35 0.006534727 673 0.04183298892421991 2.045425 14 24 0.002614379 GO Biological Process heterochromatin organization 76 2.875818e-11 4.979327508157895e-9 5.004028 27 0.005041075 510 0.01065773728 2.697264 10 13 0.001867414 GO Biological Process platelet formation 156 8.147837e-8 0.000006872909428397435 3.411445 27 0.005041075 640 0.0357567862125 2.214595 12 19 0.002240896 GO Biological Process histone H4 acetylation 165 1.284598e-7 0.000010244863686060605 2.431 45 0.008401792 336 0.0008145370087202381 1.99386 29 51 0.0054155 GO Biological Process regulation of telomere capping 183 2.998618e-7 0.00002156219358579235 2.613531 37 0.00690814 407 0.0032905388933660937 2.292674 17 26 0.003174603 GO Biological Process axonal transport 194 5.08796e-7 0.00003451158022680412 2.518011 38 0.007094847 558 0.018135521558064516 1.888084 21 39 0.003921569 GO Biological Process regulation of homotypic cell-cell adhesion 200 6.064537e-7 0.0000399016211915 2.372791 42 0.007841673 458 0.006805498642139738 2.244123 16 25 0.002987862 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 213 0.000001043155 0.00006444543025821596 2.735483 31 0.005787901 516 0.011552691580813955 2.157811 16 26 0.002987862 GO Biological Process axo-dendritic transport 238 0.000002445574 0.00013521558094957984 2.267346 41 0.007654966 540 0.014846266474814813 1.829448 24 46 0.004481793 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 245 0.000002713214 0.00014572727765714287 2.7676 28 0.005227782 532 0.013368621385902257 2.191527 15 24 0.00280112 GO Biological Process blood vessel endothelial cell migration 252 0.000003744172 0.0001955141243968254 2.115578 46 0.008588499 581 0.022555749039586917 2.103866 15 25 0.00280112 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 281 0.000008517357 0.0003988608568078292 2.105047 43 0.008028379 435 0.005157889366666666 2.176413 18 29 0.003361345 GO Biological Process maintenance of protein localization in organelle 282 0.000008699816 0.0004059605629219858 2.92135 23 0.004294249 647 0.03772313105718702 1.922888 17 31 0.003174603 GO Biological Process lung vasculature development 295 0.00001008519 0.0004498678481694915 3.976636 15 0.002800597 531 0.013306321324293786 3.506443 6 6 0.001120448 GO Biological Process positive regulation of telomere capping 357 0.00004091206 0.0015080162396078432 2.466338 26 0.004854369 666 0.04066737578528529 2.268875 11 17 0.002054155 GO Biological Process placenta blood vessel development 386 0.0000601386 0.002050165381865285 2.095426 35 0.006534727 647 0.03772313105718702 1.922888 17 31 0.003174603 GO Biological Process maternal placenta development 427 0.0001005084 0.00309740055175644 2.063803 34 0.006348021 570 0.02123849671859649 1.972374 18 32 0.003361345 GO Biological Process histone H2A acetylation 454 0.0001353344 0.003922610946255507 3.011421 16 0.002987304 507 0.010700480930374753 2.571391 11 15 0.002054155 GO Biological Process cellular response to arsenic-containing substance 476 0.0001605066 0.00443719821302521 2.851885 17 0.00317401 507 0.010700480930374753 2.571391 11 15 0.002054155 GO Biological Process negative regulation of pri-miRNA transcription from RNA polymerase II promoter 595 0.0005326378 0.011779799681008405 2.199243 23 0.004294249 347 0.0010936418354466858 3.187675 10 11 0.001867414 GO Cellular Component axon cytoplasm 62 2.242739e-7 0.000006250730632258064 2.568577 39 0.007281553 81 0.008336302933333333 1.928543 22 40 0.00410831 GO Cellular Component NuA4 histone acetyltransferase complex 100 0.00005815224 0.0010048707072 2.797125 20 0.00373413 72 0.0036437111999999996 2.532431 13 18 0.002427638 GO Cellular Component H4 histone acetyltransferase complex 107 0.00009124395 0.0014735471551401871 2.128914 32 0.005974608 51 0.0003628471341176471 2.240227 23 36 0.004295051 GO Cellular Component multivesicular body membrane 118 0.0001680698 0.002461225545762712 3.083623 15 0.002800597 91 0.02080399964835165 2.805154 8 10 0.001493931 GO Molecular Function chromatin DNA binding 18 2.036233e-11 4.776097625555555e-9 2.16534 93 0.0173637 102 0.037223825933333336 1.517211 45 104 0.008403361 GO Molecular Function 14-3-3 protein binding 80 0.0001187468 0.006266862370000001 2.021244 35 0.006534727 87 0.01149480264137931 2.244123 16 25 0.002987862 Human Phenotype Trigonocephaly 39 0.00006522547 0.011160245161794872 2.444337 25 0.004667662 55 0.01842006427090909 2.532431 13 18 0.002427638 Mouse Phenotype Single KO abnormal sternebra number 2 5.135709e-19 2.35138436565e-15 9.097676 30 0.005601195 617 0.040599125243111836 2.427537 9 13 0.001680672 Mouse Phenotype Single KO increased sternebra number 4 4.88683e-16 1.11871755775e-12 9.610898 24 0.004480956 627 0.04148491953429027 3.005522 6 7 0.001120448 Mouse Phenotype Single KO vertebral transformation 5 6.783324e-15 1.24229795736e-11 2.467983 96 0.01792382 90 0.000001711951004777778 1.981902 52 92 0.009710551 Mouse Phenotype Single KO thoracic vertebral transformation 9 3.588115e-13 3.650707672777778e-10 3.183526 55 0.01026886 290 0.0016348086827586207 1.972374 27 48 0.005042017 Mouse Phenotype Single KO absent hypoglossal nerve 16 5.410733e-11 3.0966301300625e-8 5.263968 25 0.004667662 600 0.03662387935 2.337628 10 15 0.001867414 Mouse Phenotype Single KO subcutaneous edema 17 1.355381e-10 7.300719892352941e-8 3.281947 41 0.007654966 215 0.0006807509717209303 2.337628 20 30 0.003734827 Mouse Phenotype Single KO abnormal hypoglossal nerve topology 18 1.689218e-10 8.593427347777778e-8 4.31131 29 0.005414488 472 0.01677870672733051 2.337628 12 18 0.002240896 Mouse Phenotype Single KO cervical vertebral transformation 21 5.82406e-10 2.5395674961904767e-7 2.975528 44 0.008215086 269 0.0013014415184758365 2.122321 23 38 0.004295051 Mouse Phenotype Single KO small superior cervical ganglion 27 2.275312e-9 7.716678512592592e-7 3.126229 38 0.007094847 162 0.00015416906079012346 2.410679 22 32 0.00410831 Mouse Phenotype Single KO heterochrony 30 4.650283e-9 0.0000014194213810333334 3.520244 31 0.005787901 299 0.0017508762820401338 2.681397 13 17 0.002427638 Mouse Phenotype Single KO lymphoid hyperplasia 35 1.608439e-8 0.0000042081359779999994 2.851825 39 0.007281553 348 0.004486548458333333 2.176413 18 29 0.003361345 Mouse Phenotype Single KO absent ductus venosus valve 36 1.742276e-8 0.000004431672592222222 2.992179 36 0.006721434 234 0.0008535149695299145 2.55014 16 22 0.002987862 Mouse Phenotype Single KO abnormal stapedial artery morphology 44 4.041261e-8 0.000008410415222045455 3.641763 26 0.004854369 411 0.008678024288564477 2.475136 12 17 0.002240896 Mouse Phenotype Single KO large lymphoid organs 47 6.123287e-8 0.000011929987033829787 2.629193 41 0.007654966 380 0.006225733452105263 2.08195 19 32 0.003548086 Mouse Phenotype Single KO abnormal rib development 48 6.723222e-8 0.000012825946636249999 2.879777 35 0.006534727 579 0.0325515851105354 2.268875 11 17 0.002054155 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 57 9.888128e-8 0.000015885190894035088 2.45441 45 0.008401792 486 0.018050813500411524 1.895374 20 37 0.003734827 Mouse Phenotype Single KO absent superior cervical ganglion 71 2.318027e-7 0.00002989601864647887 5.443699 15 0.002800597 627 0.04148491953429027 3.005522 6 7 0.001120448 Mouse Phenotype Single KO absent segment of posterior cerebral artery 74 2.751738e-7 0.000034050898467567565 3.202483 27 0.005041075 443 0.01322280721805869 2.231373 14 22 0.002614379 Mouse Phenotype Single KO absent stapedial artery 78 3.32705e-7 0.00003905871391025641 3.454288 24 0.004480956 490 0.018285420816122448 2.410679 11 16 0.002054155 Mouse Phenotype Single KO abnormal sixth pharyngeal arch artery morphology 86 4.572668e-7 0.0000486882800883721 2.429468 41 0.007654966 411 0.008678024288564477 2.475136 12 17 0.002240896 Mouse Phenotype abnormal sternebra number 4 5.135709e-19 1.2275628437249999e-15 9.097676 30 0.005601195 937 0.027913375213447174 2.427537 9 13 0.001680672 Mouse Phenotype increased sternebra number 10 4.88683e-16 4.672298163000001e-13 9.610898 24 0.004480956 947 0.028678598103484686 3.005522 6 7 0.001120448 Mouse Phenotype thoracic vertebral transformation 11 9.439513e-14 8.204653072090909e-11 3.033146 62 0.0115758 248 0.00003491735028629032 2.091562 34 57 0.006349206 Mouse Phenotype sacral vertebral transformation 13 2.135962e-13 1.5709178986153845e-10 6.229575 27 0.005041075 613 0.004918769528711256 2.337628 14 21 0.002614379 Mouse Phenotype abnormal rib development 15 2.992486e-13 1.9074105764e-10 3.329542 52 0.009708738 416 0.0006531601746634616 2.231373 21 33 0.003921569 Mouse Phenotype absent hypoglossal nerve 24 5.410733e-11 2.1555007588750002e-8 5.263968 25 0.004667662 909 0.025240724455445545 2.337628 10 15 0.001867414 Mouse Phenotype cervical vertebral transformation 27 1.287938e-10 4.560731562222222e-8 2.743887 54 0.01008215 362 0.0003251587812430939 2.120175 26 43 0.004855275 Mouse Phenotype subcutaneous edema 28 1.355381e-10 4.628142050357143e-8 3.281947 41 0.007654966 381 0.0004010992576377953 2.337628 20 30 0.003734827 Mouse Phenotype abnormal hypoglossal nerve topology 29 1.689218e-10 5.569176999310345e-8 4.31131 29 0.005414488 732 0.011296385501229508 2.337628 12 18 0.002240896 Mouse Phenotype enlarged liver sinusoidal spaces 36 1.715838e-9 4.5569797549999995e-7 2.518857 55 0.01026886 694 0.00850659941887608 1.881506 22 41 0.00410831 Mouse Phenotype heterochrony 43 4.650283e-9 0.0000010339850177441861 3.520244 31 0.005787901 456 0.0011987038751973683 2.681397 13 17 0.002427638 Mouse Phenotype lymphoid hyperplasia 47 1.145001e-8 0.000002329224374680851 2.760281 42 0.007841673 469 0.0013112562900639657 2.191527 20 32 0.003734827 Mouse Phenotype absent ductus venosus valve 53 1.742276e-8 0.000003143000157735849 2.992179 36 0.006721434 399 0.0005226418809774436 2.55014 16 22 0.002987862 Mouse Phenotype abnormal mesangial cell morphology 60 3.779732e-8 0.0000060230029420000005 2.31332 54 0.01008215 934 0.027606486677730194 1.683092 24 50 0.004481793 Mouse Phenotype large lymphoid organs 63 4.258598e-8 0.000006462929440952381 2.561681 44 0.008215086 555 0.00300886564972973 2.045425 21 36 0.003921569 Mouse Phenotype abnormal stapedial artery morphology 69 7.625074e-8 0.000010565700364347825 3.171736 30 0.005601195 400 0.000522492157275 2.629832 15 20 0.00280112 Mouse Phenotype fusion of vertebral arches 77 1.481367e-7 0.00001839396089220779 2.056427 64 0.01194922 337 0.0002359471240148368 2.012958 31 54 0.005788982 Mouse Phenotype absent superior cervical ganglion 88 2.318027e-7 0.000025184836530681817 5.443699 15 0.002800597 947 0.028678598103484686 3.005522 6 7 0.001120448 Mouse Phenotype absent segment of posterior cerebral artery 90 2.751738e-7 0.00002923263002 3.202483 27 0.005041075 696 0.008787559058620689 2.231373 14 22 0.002614379 Mouse Phenotype increased anti-histone antibody level 92 2.945857e-7 0.00003061449867065218 3.111552 28 0.005227782 870 0.022619424789655174 2.268875 11 17 0.002054155