# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process adherens junction assembly 131 2.982506e-35 2.995938660610687e-33 2.428252 254 0.00889979 961 0.01644182132778356 1.353804 31 34 0.002451368 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 184 1.314909e-26 9.403743223369564e-25 2.17735 237 0.008304135 950 0.01597485978105263 1.382416 27 29 0.002135062 GO Biological Process gene silencing by miRNA 189 3.014402e-26 2.098757455978836e-24 2.301746 207 0.007252978 943 0.014797079206786851 1.316088 39 44 0.003083979 GO Biological Process posttranscriptional gene silencing by RNA 211 9.56068e-25 5.962511285308057e-23 2.144606 227 0.007953749 709 0.0025474283524682647 1.339247 46 51 0.003637514 GO Biological Process cotranslational protein targeting to membrane 212 1.052235e-24 6.531302058962265e-23 2.022473 261 0.00914506 1083 0.0306723531966759 1.196945 79 98 0.006247035 GO Biological Process posttranscriptional gene silencing 215 2.143172e-24 1.3117209464186045e-22 2.126467 228 0.007988788 691 0.001935900281910275 1.342046 47 52 0.00371659 GO Biological Process placenta blood vessel development 224 6.994271e-24 4.1088219682589285e-22 2.235856 199 0.00697267 866 0.009005218815588915 1.389023 29 31 0.002293215 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 242 4.52617e-23 2.4611516954545454e-21 2.763502 128 0.004484933 929 0.01349835630365985 1.42295 23 24 0.001818757 GO Biological Process positive regulation of pri-miRNA transcription from RNA polymerase II promoter 325 1.657591e-19 6.711458452e-18 2.425823 135 0.004730203 1181 0.043773118230313296 1.410576 19 20 0.001502451 GO Biological Process regulation of Rac protein signal transduction 551 3.539158e-14 8.452228697277678e-13 2.283795 107 0.003749124 1184 0.04379533034797298 1.484817 14 14 0.001107069 GO Biological Process response to laminar fluid shear stress 708 3.82927e-12 7.117141798022599e-11 2.040812 116 0.004064471 1184 0.04379533034797298 1.484817 14 14 0.001107069 GO Biological Process maintenance of protein location in nucleus 1466 0.000001037138 0.000009309480860845839 2.018265 58 0.002032235 1013 0.023200564052319843 1.484817 16 16 0.001265222 GO Cellular Component cleavage furrow 58 4.64182e-25 1.3829422344827587e-23 2.074186 249 0.008724597 155 0.015558622141935484 1.284938 45 52 0.003558437 GO Molecular Function RNA polymerase II repressing transcription factor binding 58 3.065721e-20 2.231633458965517e-18 2.196247 173 0.006061668 160 0.030432387099999996 1.382416 27 29 0.002135062 GO Molecular Function NF-kappaB binding 82 2.573992e-15 1.3252919785365852e-13 2.290612 116 0.004064471 168 0.040305448654761905 1.378759 26 28 0.002055986 Mouse Phenotype Single KO vertebral transformation 13 9.458232e-56 6.662233109538462e-53 2.267542 470 0.01646811 173 5.257964749884393e-7 1.371842 85 92 0.006721493 Mouse Phenotype Single KO thoracic vertebral transformation 25 2.552242e-41 9.348351997600001e-39 2.693915 248 0.008689559 350 0.00033359840537142854 1.392016 45 48 0.003558437 Mouse Phenotype Single KO cervical vertebral transformation 49 2.35561e-33 4.402106279591836e-31 2.62705 207 0.007252978 236 0.000011412217776694913 1.484817 38 38 0.003004903 Mouse Phenotype Single KO abnormal facial nerve morphology 52 1.160257e-32 2.043167951730769e-30 2.306519 260 0.009110021 702 0.020920444827635328 1.378759 26 28 0.002055986 Mouse Phenotype Single KO abnormal cellular replicative senescence 135 3.715752e-22 2.5203808195555555e-20 2.062778 221 0.007743518 891 0.04428236815937149 1.237348 50 60 0.003953819 Mouse Phenotype Single KO lumbar vertebral transformation 207 3.22889e-18 1.4283548661835748e-16 2.273042 143 0.005010512 547 0.005685711875137112 1.367595 35 38 0.002767674 Mouse Phenotype Single KO abnormal thyroid cartilage morphology 246 4.036161e-17 1.502403507195122e-15 2.00449 179 0.006271899 626 0.01183988251485623 1.484817 18 18 0.001423375 Mouse Phenotype Single KO increased hemangiosarcoma incidence 456 1.58022e-11 3.1732619605263157e-10 2.020361 112 0.003924317 649 0.013445663313251156 1.42295 23 24 0.001818757 Mouse Phenotype Single KO increased lactate dehydrogenase level 473 3.105468e-11 6.012002214799153e-10 2.09866 99 0.003468816 736 0.024157795846467392 1.417326 21 22 0.001660604 Mouse Phenotype Single KO absent segment of posterior cerebral artery 568 4.891791e-10 7.886290525880281e-9 2.047847 92 0.003223546 736 0.024157795846467392 1.417326 21 22 0.001660604 Mouse Phenotype thoracic vertebral transformation 36 8.31346e-53 2.2079164183333336e-50 2.781832 303 0.01061668 483 0.00008084451022981365 1.38062 53 57 0.004191049 Mouse Phenotype abnormal rib development 67 5.692283e-41 8.122972800447761e-39 2.787762 232 0.008128942 809 0.0035721006919653894 1.394828 31 33 0.002451368 Mouse Phenotype sacral vertebral transformation 69 2.678533e-40 3.711515074347826e-38 4.849526 112 0.003924317 1176 0.022475967905612244 1.414112 20 21 0.001581528 Mouse Phenotype abnormal liver sinusoid morphology 71 2.518357e-39 3.391269193943662e-37 2.025429 425 0.01489138 1190 0.02247966251092437 1.218312 64 78 0.005060889 Mouse Phenotype cervical vertebral transformation 109 4.931805e-32 4.32596216559633e-30 2.345817 246 0.008619481 321 0.000001207572766728972 1.484817 43 43 0.003400285 Mouse Phenotype abnormal fourth pharyngeal arch morphology 134 1.553475e-28 1.108416005597015e-26 2.003 312 0.01093203 1208 0.023903521000827814 1.341125 28 31 0.002214139 Mouse Phenotype early cellular replicative senescence 144 2.135448e-27 1.417848495e-25 2.023948 291 0.01019622 1071 0.012835539837535015 1.240738 61 73 0.00482366 Mouse Phenotype abnormal metanephros morphology 164 1.449987e-25 8.453247382317072e-24 2.11802 242 0.008479327 578 0.0003797197466262976 1.484817 27 27 0.002135062 Mouse Phenotype abnormal thyroid cartilage morphology 175 1.039423e-24 5.678813316e-23 2.051341 252 0.008829713 606 0.0005381254233168316 1.484817 26 26 0.002055986 Mouse Phenotype abnormal parathyroid gland morphology 232 1.35017e-20 5.564213521551724e-19 2.05518 206 0.00721794 966 0.008190750339751552 1.38583 28 30 0.002214139 Mouse Phenotype abnormal stapedial artery morphology 245 4.028799e-20 1.5722182546530613e-18 2.539641 128 0.004484933 1268 0.02962228530757098 1.410576 19 20 0.001502451 Mouse Phenotype absent stapedial artery 252 5.432258e-20 2.0610245530952385e-18 2.551624 126 0.004414856 1381 0.03857020248877625 1.406669 18 19 0.001423375 Mouse Phenotype increased thyroid tumor incidence 255 5.825397e-20 2.184181204588235e-18 2.35395 147 0.005150666 1305 0.03115361368505747 1.366032 23 25 0.001818757 Mouse Phenotype short premaxilla 297 1.878241e-18 6.04641824949495e-17 2.058118 182 0.006377015 900 0.005788342007333334 1.484817 19 19 0.001502451 Mouse Phenotype increased embryonic neuroepithelium apoptosis 368 2.198953e-16 5.713095008967391e-15 2.282722 126 0.004414856 1305 0.03115361368505747 1.366032 23 25 0.001818757 Mouse Phenotype lymphoid hyperplasia 378 3.722706e-16 9.416082557142859e-15 2.022714 164 0.005746321 1142 0.018641363004378284 1.345616 29 32 0.002293215 Mouse Phenotype abnormal ureteric bud invasion 452 1.410266e-14 2.983086996902655e-13 2.076176 137 0.00480028 1103 0.015481495389845874 1.484817 16 16 0.001265222 Mouse Phenotype decreased DN4 thymocyte number 455 1.594019e-14 3.3495419030769227e-13 2.031216 144 0.00504555 1381 0.03857020248877625 1.406669 18 19 0.001423375 Mouse Phenotype decreased classified tumor incidence 531 2.552173e-13 4.595353305649718e-12 2.022135 132 0.004625088 1471 0.048124952267845 1.32573 25 28 0.00197691 Mouse Phenotype increased colon adenocarcinoma incidence 534 2.744188e-13 4.913329862921348e-12 2.965974 62 0.00217239 1398 0.0400287131609442 1.484817 13 13 0.001027993