# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of adaptive immune response 190 1.087033e-143 7.528561708947369e-142 2.02753 1602 0.02302154 587 0.0020716211458262353 1.146236 122 131 0.007996854 GO Biological Process interferon-gamma-mediated signaling pathway 216 4.269178e-128 2.600838578796296e-126 2.667342 808 0.01161136 385 0.000056376710638961044 1.230794 64 64 0.004195071 GO Biological Process cellular response to interferon-gamma 220 1.558813e-126 9.32382739409091e-125 2.165633 1206 0.01733082 456 0.0003420384818201754 1.168738 113 119 0.007406922 GO Biological Process response to interferon-gamma 238 2.147021e-120 1.1870861066806725e-118 2.024215 1347 0.01935706 350 0.00001440395419142857 1.178046 134 140 0.008783429 GO Biological Process regulation of type I interferon production 270 2.424428e-105 1.1815943722962964e-103 2.076385 1106 0.01589377 687 0.005379724822998544 1.140736 114 123 0.00747247 GO Biological Process tumor necrosis factor-mediated signaling pathway 279 1.159688e-103 5.469653903942651e-102 2.108562 1049 0.01507465 858 0.016559573932400932 1.125023 117 128 0.007669114 GO Biological Process intrinsic apoptotic signaling pathway in response to DNA damage 331 1.409718e-90 5.60437436918429e-89 2.354066 719 0.01033239 447 0.00029100910655257265 1.212957 68 69 0.004457263 GO Biological Process B cell receptor signaling pathway 347 7.880965e-88 2.9886345370317005e-86 2.415233 662 0.009513271 790 0.011532457652405063 1.230794 35 35 0.002294179 GO Biological Process regulation of B cell proliferation 376 7.995345e-81 2.7981581078457447e-79 2.009306 917 0.01317775 560 0.0016118696431964288 1.209934 58 59 0.003801783 GO Biological Process regulation of toll-like receptor signaling pathway 440 5.634873e-69 1.6852112228863636e-67 2.205765 625 0.008981563 997 0.031495228389167504 1.168212 56 59 0.003670687 GO Biological Process nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 465 2.041205e-64 5.776390665591398e-63 2.405214 486 0.006984063 954 0.02702613075681342 1.230794 30 30 0.001966439 GO Biological Process interleukin-12-mediated signaling pathway 500 7.132586e-60 1.8771539834799998e-58 2.119494 592 0.008507336 1062 0.04070882861111111 1.166016 54 57 0.003539591 GO Biological Process nucleotide-binding oligomerization domain containing signaling pathway 527 9.48983e-58 2.3695763371916507e-56 2.337517 460 0.00661043 1000 0.031744824236 1.230794 29 29 0.001900891 GO Biological Process response to interleukin-12 544 1.787116e-56 4.3229153389705884e-55 2.027351 621 0.008924081 1031 0.03575089704946654 1.167133 55 58 0.003605139 GO Biological Process cytoplasmic pattern recognition receptor signaling pathway 573 1.994545e-53 4.5804917373472954e-52 2.202625 482 0.006926581 790 0.011532457652405063 1.230794 35 35 0.002294179 GO Biological Process negative regulation of adaptive immune response 588 2.07445e-52 4.642463869047619e-51 2.15966 494 0.007099027 1045 0.038012560704306225 1.199236 38 39 0.002490823 GO Biological Process liver regeneration 652 5.522289e-47 1.1145368244018405e-45 2.175021 434 0.006236797 790 0.011532457652405063 1.230794 35 35 0.002294179 GO Biological Process T cell differentiation involved in immune response 705 7.157098e-43 1.335890107546099e-41 2.006594 479 0.00688347 921 0.022736665991313788 1.230794 31 31 0.002031987 GO Biological Process alpha-beta T cell differentiation involved in immune response 711 1.31722e-42 2.437875946554149e-41 2.016462 470 0.006754135 1090 0.04414805868073394 1.230794 27 27 0.001769795 GO Biological Process MyD88-independent toll-like receptor signaling pathway 720 2.716202e-42 4.964236405277778e-41 2.047218 449 0.006452355 734 0.00818657066307902 1.230794 37 37 0.002425275 GO Molecular Function cytokine receptor activity 24 1.188666e-94 2.091061605e-92 2.041057 1035 0.01487347 127 0.024549184685039367 1.150525 86 92 0.005637126 Human Phenotype Abnormality of lymphocytes 4 7.350435e-127 1.226236318875e-123 2.013353 1439 0.02067915 88 0.007060881016022727 1.142248 129 139 0.00845569 Human Phenotype Decreased antibody level in blood 8 2.134471e-98 1.780415622875e-95 2.140294 961 0.01381005 75 0.004482122419466667 1.185765 79 82 0.005178291 Human Phenotype Abnormality of the lymph nodes 19 1.296668e-62 4.554034507368421e-60 2.166851 589 0.008464225 115 0.022251988891304347 1.206179 49 50 0.003211851 Mouse Phenotype Single KO abnormal lymphocyte physiology 1 0 0 2.047128 10676 0.1534195 8 2.44228865175e-25 1.156633 811 863 0.05315941 Mouse Phenotype Single KO abnormal T cell physiology 1 0 0 2.232447 7008 0.1007085 20 1.5569839396999998e-16 1.162808 496 525 0.0325118 Mouse Phenotype Single KO abnormal B cell physiology 1 0 0 2.052784 6680 0.09599494 21 1.6585677296666665e-16 1.160398 511 542 0.03349502 Mouse Phenotype Single KO abnormal T cell activation 1 0 0 2.318647 4075 0.05855979 33 1.227944543e-13 1.192465 280 289 0.01835343 Mouse Phenotype Single KO abnormal immunoglobulin level 1 0 0 2.117821 5546 0.07969879 36 5.010313596666666e-13 1.157111 424 451 0.02779234 Mouse Phenotype Single KO abnormal T cell proliferation 1 0 0 2.314102 3742 0.05377441 42 2.0908317635238094e-12 1.193069 253 261 0.01658364 Mouse Phenotype Single KO abnormal humoral immune response 1 0 0 2.066869 5938 0.08533203 49 1.8024859315510202e-11 1.14306 456 491 0.02988988 Mouse Phenotype Single KO abnormal IgG level 1 0 0 2.081602 4258 0.06118959 52 3.728186262884616e-11 1.16398 331 350 0.02169638 Mouse Phenotype Single KO decreased immunoglobulin level 1 0 0 2.268715 3576 0.05138891 73 5.373409134931507e-9 1.164859 265 280 0.01737021 Mouse Phenotype Single KO abnormal cytokine secretion 1 0 0 2.109201 6569 0.09439982 87 3.50555746954023e-8 1.114397 517 571 0.03388831 Mouse Phenotype Single KO abnormal immune tolerance 1 0 0 2.207285 3893 0.05594436 131 0.0000011081857320610687 1.132477 311 338 0.02038542 Mouse Phenotype Single KO abnormal interleukin secretion 1 0 0 2.064773 4963 0.07132079 132 0.0000015500664366666666 1.118904 380 418 0.02490823 Mouse Phenotype Single KO abnormal self tolerance 1 0 0 2.203268 3853 0.05536954 135 0.0000020404990775555555 1.131 306 333 0.02005768 Mouse Phenotype Single KO autoimmune response 1 0 0 2.235001 3840 0.05518272 140 0.0000025376107324999998 1.130397 304 331 0.01992659 Mouse Phenotype Single KO abnormal B cell activation 1 0 0 2.497103 2331 0.03349764 143 0.0000032402050903496505 1.18221 146 152 0.009570005 Mouse Phenotype Single KO abnormal mature B cell number 1 0 0 2.016776 3965 0.05697903 157 0.0000066876953840764326 1.137147 255 276 0.01671474 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 1 0 0 2.263918 3108 0.04466351 191 0.000038894534886911 1.131765 240 261 0.01573152 Mouse Phenotype Single KO increased susceptibility to infection 1 0 0 2.045307 4235 0.06085907 639 0.03914068653208137 1.063758 363 420 0.02379392 Mouse Phenotype Single KO abnormal response to infection 1 0 0 2.001265 5658 0.08130829 656 0.04155653190853659 1.054344 484 565 0.03172522 Mouse Phenotype Single KO decreased IgG level 75 7e-323 8.444e-321 2.233657 2861 0.041114 82 2.234992541585366e-8 1.175848 214 224 0.01402727 Mouse Phenotype abnormal B cell physiology 1 0 0 2.025103 8189 0.11768 36 1.6035966815833333e-16 1.144968 627 674 0.04109858 Mouse Phenotype abnormal T cell physiology 1 0 0 2.046831 8687 0.1248365 40 5.26395435525e-15 1.13707 643 696 0.04214735 Mouse Phenotype abnormal immunoglobulin level 1 0 0 2.05787 6755 0.09707273 67 3.103965806865672e-12 1.139044 509 550 0.03336392 Mouse Phenotype abnormal T cell activation 1 0 0 2.12301 5402 0.07762944 72 1.068454099625e-11 1.155563 384 409 0.02517042 Mouse Phenotype decreased immunoglobulin level 1 0 0 2.20935 4530 0.06509837 92 1.180453021956522e-10 1.160059 328 348 0.02149974 Mouse Phenotype abnormal humoral immune response 1 0 0 2.028324 7300 0.1049047 96 2.15648355e-10 1.123948 547 599 0.03585475 Mouse Phenotype abnormal IgG level 1 0 0 2.090904 5397 0.07755759 102 4.73980201e-10 1.142063 399 430 0.02615364 Mouse Phenotype abnormal spleen white pulp morphology 1 0 0 2.078949 4524 0.06501214 103 5.37295247038835e-10 1.15281 340 363 0.02228631 Mouse Phenotype abnormal T cell proliferation 1 0 0 2.127064 4748 0.06823114 105 8.680537526285713e-10 1.150525 344 368 0.02254851 Mouse Phenotype decreased IgG level 1 0 0 2.261547 3582 0.05147513 106 8.671904570377358e-10 1.171753 258 271 0.01691138 Mouse Phenotype abnormal B cell activation 1 0 0 2.394013 3102 0.04457729 115 2.5320063743478263e-9 1.188767 198 205 0.0129785 Mouse Phenotype abnormal immune tolerance 1 0 0 2.070343 5077 0.07295903 121 4.982744386115702e-9 1.134594 401 435 0.02628474 Mouse Phenotype abnormal self tolerance 1 0 0 2.065286 5023 0.07218302 122 5.055314487540984e-9 1.135674 394 427 0.0258259 Mouse Phenotype abnormal B cell proliferation 1 0 0 2.390235 2913 0.04186127 124 6.1098375375e-9 1.191722 183 189 0.01199528 Mouse Phenotype autoimmune response 1 0 0 2.086228 5010 0.07199621 125 6.420063878159999e-9 1.135227 392 425 0.02569481 Mouse Phenotype abnormal IgG1 level 1 0 0 2.241339 3225 0.04634486 162 9.152945962962963e-8 1.163847 226 239 0.01481384 Mouse Phenotype abnormal lymph node morphology 1 0 0 2.02451 5312 0.0763361 169 1.4568797217159763e-7 1.127723 372 406 0.02438385 Mouse Phenotype abnormal mature B cell number 1 0 0 2.021137 5240 0.07530142 187 3.950119992032086e-7 1.127691 350 382 0.02294179 Mouse Phenotype decreased mature B cell number 1 0 0 2.059009 4281 0.06152011 199 8.36006152763819e-7 1.141668 269 290 0.01763241 Mouse Phenotype increased immunoglobulin level 1 0 0 2.030974 3886 0.05584376 212 0.0000014072425498584905 1.132331 299 325 0.01959885