# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process tumor necrosis factor-mediated signaling pathway 161 5.148244e-117 4.207810111552795e-115 2.180205 1098 0.01558685 529 0.00015803924174669187 1.145768 124 128 0.007810532 GO Biological Process interferon-gamma-mediated signaling pathway 177 2.91888e-109 2.170030616949153e-107 2.507712 769 0.01091647 605 0.00046161380492561985 1.182729 64 64 0.004031242 GO Biological Process intrinsic apoptotic signaling pathway in response to DNA damage 187 2.086616e-106 1.46833047828877e-104 2.477437 766 0.01087389 731 0.002248131443638851 1.165588 68 69 0.004283195 GO Biological Process cellular response to interferon-gamma 189 7.86438e-106 5.475522561904762e-104 2.045271 1153 0.01636761 846 0.00566298964893617 1.123095 113 119 0.007117662 GO Biological Process regulation of type I interferon production 211 6.951656e-98 4.3353953224644545e-96 2.025161 1092 0.01550168 348 9.010273587068966e-7 1.173113 122 123 0.007684555 GO Biological Process negative regulation of type I interferon production 268 3.927159e-80 1.9282643761567163e-78 2.833557 453 0.00643064 852 0.005735957132042253 1.182729 47 47 0.002960443 GO Biological Process positive regulation of cytokine biosynthetic process 285 2.116177e-76 9.77079759403509e-75 2.164589 724 0.01027767 1142 0.03430765623467601 1.143304 58 60 0.003653313 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 350 4.663098e-64 1.7531916166285718e-62 2.236476 562 0.007977968 996 0.01646452494578313 1.160826 53 54 0.003338372 GO Biological Process regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 473 6.165054e-50 1.715136270317125e-48 2.06416 523 0.007424337 1206 0.045212949179104484 1.157017 45 46 0.002834467 GO Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 484 6.196813e-49 1.6847905427066117e-47 2.139847 470 0.006671966 1076 0.024425452074349444 1.182729 37 37 0.002330562 GO Biological Process liver regeneration 632 1.114425e-37 2.3203668631329114e-36 2.024795 409 0.00580603 1134 0.032442377302469134 1.182729 35 35 0.002204586 GO Molecular Function polyubiquitin binding 38 9.344169e-52 1.038186355736842e-49 2.276768 434 0.006160922 130 0.016887032187692306 1.182729 45 45 0.002834467 Human Phenotype Decreased antibody level in blood 8 9.668788e-85 8.0649777905e-82 2.039454 927 0.01315939 156 0.0007019371475641026 1.168305 81 82 0.005102041 Mouse Phenotype Single KO abnormal T cell physiology 1 0 0 2.105848 6692 0.09499744 38 1.1844278282894737e-12 1.126408 500 525 0.03149408 Mouse Phenotype Single KO abnormal T cell activation 1 0 0 2.185332 3888 0.05519278 54 1.0545243593518519e-9 1.145896 280 289 0.01763668 Mouse Phenotype Single KO abnormal T cell proliferation 1 0 0 2.188207 3582 0.0508489 62 8.083973878387097e-9 1.146476 253 261 0.015936 Mouse Phenotype Single KO abnormal immune tolerance 1 0 0 2.100339 3750 0.05323377 246 0.0009831908123577237 1.08825 311 338 0.01958932 Mouse Phenotype Single KO abnormal self tolerance 1 0 0 2.092862 3705 0.05259497 264 0.001424390773939394 1.086832 306 333 0.01927438 Mouse Phenotype Single KO autoimmune response 1 0 0 2.125018 3696 0.05246721 268 0.0016711009064552238 1.086252 304 331 0.0191484 Mouse Phenotype Single KO decreased immunoglobulin level 61 1.214666e-317 1.823392615e-315 2.076917 3314 0.04704446 114 0.0000025316414127192986 1.123592 266 280 0.01675485 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 63 3.915734e-305 5.6914882917460314e-303 2.139955 2974 0.04221793 395 0.011885099804556962 1.083035 239 261 0.01505417 Mouse Phenotype Single KO abnormal B cell activation 66 9.945757e-283 1.3798984371060607e-280 2.364076 2234 0.03171313 200 0.00026319525564 1.136042 146 152 0.009196271 Mouse Phenotype Single KO abnormal IgM level 73 1.025274e-254 1.2860868517808218e-252 2.140591 2488 0.03531883 219 0.0004788554889954338 1.12015 179 189 0.01127488 Mouse Phenotype Single KO decreased IgG level 76 5.00023e-240 6.024619225000001e-238 2.036042 2640 0.03747658 149 0.00003740255928724832 1.124648 213 224 0.01341648 Mouse Phenotype Single KO abnormal B cell proliferation 77 1.993382e-239 2.370571295324675e-237 2.282566 2035 0.02888819 210 0.00035399056471904766 1.139876 133 138 0.008377425 Mouse Phenotype Single KO abnormal tumor necrosis factor secretion 81 5.600211e-229 6.331003966296296e-227 2.090675 2365 0.03357277 507 0.038374205583826426 1.083192 185 202 0.01165281 Mouse Phenotype Single KO decreased T cell proliferation 91 9.733571e-212 9.79453952164835e-210 2.115957 2128 0.03020839 163 0.00008999786107361963 1.143304 145 150 0.009133283 Mouse Phenotype Single KO abnormal IgG1 level 92 8.12932e-210 8.09132426521739e-208 2.056116 2257 0.03203963 230 0.0006468461005652175 1.119141 176 186 0.01108592 Mouse Phenotype Single KO abnormal IgG2 level 100 8.323419e-195 7.621754778300001e-193 2.047237 2119 0.03008063 416 0.014502268879086538 1.097309 167 180 0.01051902 Mouse Phenotype Single KO abnormal interleukin-6 secretion 101 4.383911e-193 3.9746012898019806e-191 2.111177 1952 0.02770995 178 0.00015348896523033708 1.137529 151 157 0.009511212 Mouse Phenotype Single KO increased T cell proliferation 103 1.371655e-186 1.2194412461165048e-184 2.387371 1449 0.02056953 213 0.00039742725606103284 1.151329 110 113 0.006928697 Mouse Phenotype Single KO abnormal dendritic cell physiology 106 2.816206e-177 2.432830032264151e-175 2.054449 1913 0.02715632 240 0.0007796662787916668 1.128617 146 153 0.009196271 Mouse Phenotype Single KO decreased B cell proliferation 108 2.739251e-175 2.3225297599074075e-173 2.474363 1270 0.0180285 237 0.0007418479798734177 1.168127 80 81 0.005039053 Mouse Phenotype decreased immunoglobulin level 1 0 0 2.037937 4230 0.0600477 129 9.993283197674419e-8 1.121553 330 348 0.02078609 Mouse Phenotype abnormal T cell activation 1 0 0 2.015267 5191 0.07368974 154 6.396569754545454e-7 1.107543 383 409 0.02412446 Mouse Phenotype abnormal B cell activation 1 0 0 2.255868 2959 0.042005 164 0.0000013389539213414634 1.142343 198 205 0.01247166 Mouse Phenotype abnormal T cell proliferation 1 0 0 2.023742 4573 0.06491681 202 0.000012947402070297029 1.10238 343 368 0.02160494 Mouse Phenotype decreased IgG level 1 0 0 2.093705 3357 0.04765487 204 0.00001407577450147059 1.117264 256 271 0.01612497 Mouse Phenotype abnormal IgM level 1 0 0 2.130374 3307 0.04694509 391 0.0014177520291560103 1.097572 232 250 0.01461325 Mouse Phenotype altered susceptibility to autoimmune disorder 1 0 0 2.072423 3751 0.05324797 442 0.0029179631219457018 1.080648 307 336 0.01933736 Mouse Phenotype abnormal B cell proliferation 75 5.14e-322 6.5503e-320 2.259026 2787 0.03956334 170 0.000002219605834411765 1.145182 183 189 0.01152683 Mouse Phenotype abnormal IgG1 level 81 6.767563e-298 7.988230844814815e-296 2.094615 3051 0.043311 282 0.00012276459617021278 1.113447 225 239 0.01417234 Mouse Phenotype decreased susceptibility to autoimmune disorder 90 6.803568e-272 7.2276570720000005e-270 2.291284 2290 0.03250809 619 0.01289655487415186 1.089966 188 204 0.01184177 Mouse Phenotype enlarged lymph nodes 93 2.788894e-269 2.8671629606451613e-267 2.030748 2975 0.04223213 319 0.0002697859140094044 1.113156 208 221 0.01310154 Mouse Phenotype abnormal interleukin-6 secretion 96 3.620706e-249 3.605996881875e-247 2.174922 2349 0.03334564 406 0.0017509009846551726 1.108808 180 192 0.01133787 Mouse Phenotype increased mature B cell number 99 2.591557e-247 2.502815805757576e-245 2.076917 2592 0.03679518 311 0.00022001545703536975 1.121447 183 193 0.01152683 Mouse Phenotype abnormal marginal zone B cell morphology 102 3.153629e-237 2.9560634185294114e-235 2.388047 1840 0.02612004 427 0.002530821330210773 1.123167 132 139 0.008314437 Mouse Phenotype abnormal dendritic cell physiology 113 1.1617e-218 9.829215663716814e-217 2.095228 2248 0.03191187 378 0.001155056821904762 1.115908 167 177 0.01051902 Mouse Phenotype abnormal spleen marginal zone morphology 114 3.046277e-216 2.554864420789474e-214 2.19061 2009 0.02851911 411 0.0018950872057664234 1.117021 153 162 0.009637188 Mouse Phenotype abnormal follicular B cell morphology 115 6.923258e-216 5.755936498956522e-214 2.472845 1566 0.02223042 369 0.0009924729978048779 1.14828 100 103 0.006298816 Mouse Phenotype abnormal IgG2 level 116 1.475261e-213 1.2159457259482756e-211 2.001291 2455 0.03485038 532 0.007150979217857143 1.093466 196 212 0.01234568 Mouse Phenotype abnormal spleen germinal center morphology 120 1.385769e-211 1.10411145075e-209 2.278171 1807 0.02565158 321 0.0002763792908691589 1.139563 132 137 0.008314437 Mouse Phenotype abnormal spleen secondary B follicle morphology 121 2.142798e-209 1.6931646014876032e-207 2.2381 1857 0.02636137 306 0.0001940045006470588 1.140488 135 140 0.008503401