# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of immune system process 13 4.387139e-202 4.440797084692308e-199 2.043 2033 0.1529031 38 1.8829985325526315e-20 1.455226 447 897 0.06951788 GO Biological Process regulation of immune response 16 1.246223e-173 1.0249405285625e-170 2.015612 1823 0.1371089 110 3.819722743636364e-15 1.383429 433 914 0.06734059 GO Biological Process leukocyte activation 18 9.41111e-173 6.880044249444445e-170 2.005725 1835 0.1380114 144 4.666643792638889e-13 1.364336 406 869 0.06314152 GO Biological Process response to external biotic stimulus 39 1.897426e-143 6.402109931794872e-141 2.034687 1493 0.1122894 297 2.465186679057239e-7 1.284147 343 780 0.0533437 GO Biological Process response to other organism 40 2.820952e-142 9.280226842e-140 2.034386 1482 0.1114621 312 5.213557841346154e-7 1.27783 340 777 0.05287714 GO Biological Process regulation of cytokine production 43 1.61144e-136 4.931381153488372e-134 2.05549 1392 0.1046931 83 3.685480765542169e-17 1.507981 315 610 0.04898911 GO Biological Process regulation of leukocyte activation 53 1.034417e-128 2.568281755283019e-126 2.074475 1289 0.09694645 46 5.904471906521739e-20 1.636329 260 464 0.04043546 GO Biological Process regulation of cell activation 56 7.878498e-127 1.8513063425357144e-124 2.023371 1346 0.1012335 41 2.6784213741463417e-20 1.617801 277 500 0.04307932 GO Biological Process lymphocyte activation 57 1.706681e-124 3.9400377682456143e-122 2.255782 1043 0.07844465 104 7.810405512884615e-16 1.653112 197 348 0.03063764 GO Biological Process regulation of lymphocyte activation 58 1.16618e-123 2.64582114137931e-121 2.133934 1165 0.08762034 62 2.509476482903226e-18 1.657224 227 400 0.03530327 GO Biological Process adaptive immune response 63 1.950519e-115 4.0741078604761904e-113 2.662939 712 0.05354994 204 6.936753949019608e-10 1.585886 145 267 0.02255054 GO Biological Process positive regulation of cell activation 66 7.708877e-113 1.5369865521666669e-110 2.272206 934 0.07024669 61 2.546723829180328e-18 1.757894 183 304 0.02846034 GO Biological Process cytokine-mediated signaling pathway 68 1.344474e-112 2.6017549067647056e-110 2.13415 1064 0.08002407 209 9.096073751674641e-10 1.40106 261 544 0.04059098 GO Biological Process positive regulation of immune response 69 2.136743e-112 4.0749856720289853e-110 2.016433 1209 0.0909296 192 2.8903770914583334e-10 1.393628 283 593 0.04401244 GO Biological Process positive regulation of leukocyte activation 73 1.606722e-108 2.896281479178082e-106 2.259981 909 0.06836643 65 3.3710179595384614e-18 1.768023 178 294 0.02768274 GO Biological Process regulation of innate immune response 79 1.239499e-103 2.0646287773417718e-101 2.232698 891 0.06701264 295 2.2950763563050845e-7 1.396931 199 416 0.03094868 GO Biological Process positive regulation of cytokine production 84 9.518658e-101 1.4911431026428572e-98 2.145365 944 0.0709988 111 4.210489971981982e-15 1.60385 212 386 0.03297045 GO Biological Process positive regulation of lymphocyte activation 87 4.985474e-100 7.540672685747127e-98 2.272183 830 0.06242479 91 6.311620357142857e-17 1.783339 160 262 0.02488336 GO Biological Process leukocyte differentiation 88 6.501764e-100 9.722353690454546e-98 2.168162 915 0.06881769 141 3.6563569402127655e-13 1.639591 169 301 0.02628305 GO Biological Process regulation of T cell activation 92 2.719994e-96 3.890478374565218e-94 2.168734 882 0.06633574 84 3.9169298716666664e-17 1.725583 182 308 0.02830482 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 50 1.661861e-30 5.743391616e-29 2.143801 282 0.02120939 30 9.71301888e-7 1.768205 66 109 0.01026439 GO Cellular Component uropod 93 2.946764e-17 5.475277625806452e-16 4.657754 47 0.003534898 95 0.005055265818947368 2.470953 11 13 0.001710731 GO Cellular Component flotillin complex 199 2.751473e-8 2.389218765829146e-7 2.99462 35 0.002632371 104 0.01962037661538462 2.595749 8 9 0.001244168 GO Molecular Function cytokine receptor activity 6 1.982193e-60 1.3948031409999998e-57 3.065338 297 0.02233755 32 0.0000205753100875 1.777524 56 92 0.008709176 GO Molecular Function chemokine receptor activity 14 3.588422e-48 1.0821655488571429e-45 5.843512 113 0.008498797 99 0.012246431286868687 2.021689 18 26 0.002799378 GO Molecular Function C-C chemokine receptor activity 33 2.062464e-39 2.6387039418181815e-37 10.36601 60 0.004512635 108 0.027080943953703702 2.433515 10 12 0.00155521 GO Molecular Function MAP kinase kinase kinase activity 53 5.064449e-32 4.034359184528302e-30 3.513634 127 0.009551745 99 0.012246431286868687 2.021689 18 26 0.002799378 GO Molecular Function signal transducer, downstream of receptor, with serine/threonine kinase activity 55 2.350318e-30 1.8041895629090908e-28 2.303076 240 0.01805054 47 0.00008323665813617021 1.835565 44 70 0.006842924 GO Molecular Function tumor necrosis factor receptor superfamily binding 59 2.746612e-28 1.9654569261016947e-26 3.141468 130 0.009777377 102 0.013648794676470588 1.739704 28 47 0.004354588 GO Molecular Function tumor necrosis factor receptor binding 66 2.437713e-26 1.5593976190909093e-24 3.519127 103 0.007746691 87 0.0034414832275862063 2.00765 22 32 0.003421462 GO Molecular Function 14-3-3 protein binding 80 1.394247e-22 7.3581385425e-21 2.814853 121 0.009100481 89 0.0061685175213483144 2.102557 18 25 0.002799378 GO Molecular Function mitogen-activated protein kinase binding 169 2.635043e-12 6.582929908875741e-11 2.591938 71 0.005339952 107 0.02311710328785047 1.946812 18 27 0.002799378 GO Molecular Function potassium channel inhibitor activity 321 9.252901e-7 0.00001217001496012461 2.610505 34 0.00255716 105 0.022155889923809527 2.920218 7 7 0.001088647 Human Phenotype Abnormality of leukocytes 2 6.979228e-58 2.3286194221999998e-54 2.118829 560 0.04211793 18 0.0026602933986111113 1.386251 122 257 0.01897356 Human Phenotype Abnormality of lymphocytes 4 6.947531e-53 1.159021859075e-49 2.555592 349 0.0262485 5 0.001806821518 1.575657 75 139 0.01166407 Human Phenotype Abnormality of B cell physiology 6 1.446804e-41 1.6090871820000002e-38 2.605806 263 0.01978039 42 0.009860700044047618 1.542757 56 106 0.008709176 Human Phenotype Abnormality of bone marrow cell morphology 7 9.479768e-41 9.036927409142857e-38 2.325241 320 0.02406739 57 0.024117743912280703 1.438637 67 136 0.01041991 Human Phenotype Abnormal leukocyte count 8 1.842709e-40 1.537049644625e-37 2.178428 365 0.02745187 66 0.031635115745454544 1.418391 68 140 0.01057543 Human Phenotype Abnormal immunoglobulin level 9 2.439858e-40 1.809019159333333e-37 2.582902 259 0.01947954 52 0.01943722989423077 1.516267 54 104 0.008398134 Human Phenotype Abnormality of cells of the lymphoid lineage 11 1.071908e-35 6.502583712727274e-33 3.23962 159 0.01195848 3 0.0022660084426666667 2.057426 31 44 0.004821151 Human Phenotype Decreased antibody level in blood 12 2.516066e-35 1.3991423681666667e-32 2.599333 223 0.01677196 38 0.006973378070789475 1.638171 46 82 0.007153966 Human Phenotype Inflammatory abnormality of the skin 17 7.757585e-32 3.045080276764706e-29 2.086904 314 0.02361613 4 0.0019211667095000002 1.590865 73 134 0.01135303 Human Phenotype Abnormality of the lymph nodes 21 4.175534e-30 1.326825637238095e-27 2.945862 153 0.01150722 12 0.002504637147 1.927344 33 50 0.005132193 Human Phenotype Lymphadenopathy 26 7.318726e-27 1.8783791768461538e-24 2.886055 140 0.01052948 32 0.00723384062625 1.901537 28 43 0.004354588 Human Phenotype Leukopenia 28 6.290142e-26 1.4990756273571428e-23 2.505639 172 0.01293622 16 0.002888704164375 1.819152 38 61 0.005909798 Human Phenotype Lymphopenia 29 1.610992e-25 3.706948143448276e-23 2.866331 134 0.01007822 11 0.002646553051272727 2.016341 29 42 0.004510109 Mouse Phenotype Single KO abnormal hematopoietic system physiology 1 0 0 2.214966 3502 0.2633875 1 3.3781152799e-53 1.586708 752 1384 0.1169518 Mouse Phenotype Single KO abnormal immune cell physiology 1 0 0 2.336086 3219 0.2421029 2 6.1160015065e-53 1.620509 687 1238 0.1068429 Mouse Phenotype Single KO abnormal cell-mediated immunity 1 0 0 2.329587 3228 0.2427798 3 5.215854670999999e-53 1.616633 692 1250 0.1076205 Mouse Phenotype Single KO abnormal blood cell physiology 1 0 0 2.250324 3324 0.25 4 8.550788286e-53 1.595856 723 1323 0.1124417 Mouse Phenotype Single KO abnormal leukocyte physiology 1 0 0 2.331205 3188 0.2397714 5 1.4698787097600002e-52 1.622343 675 1215 0.1049767 Mouse Phenotype Single KO abnormal adaptive immunity 1 0 0 2.305782 3250 0.2444344 6 3.336523880666667e-52 1.60497 698 1270 0.1085537 Mouse Phenotype Single KO abnormal lymphocyte physiology 1 0 0 2.538004 2529 0.1902076 7 3.1103791202857147e-47 1.708818 505 863 0.0785381 Mouse Phenotype Single KO abnormal lymphocyte morphology 1 0 0 2.158317 3000 0.2256318 13 1.7730804757692307e-33 1.506402 602 1167 0.09362364 Mouse Phenotype Single KO abnormal immune serum protein physiology 15 1.43e-322 8.747e-320 2.329378 2393 0.1799789 17 1.1499613764117649e-31 1.551269 502 945 0.07807154 Mouse Phenotype Single KO abnormal lymphocyte cell number 17 1.301302e-312 7.0094249494035e-310 2.128597 2757 0.2073556 20 6.3352979209999995e-31 1.507647 555 1075 0.08631415 Mouse Phenotype Single KO abnormal T cell physiology 20 1.5083e-289 6.905751550000001e-287 2.745919 1647 0.1238718 12 6.892235818e-34 1.779942 320 525 0.04976672 Mouse Phenotype Single KO abnormal professional antigen presenting cell physiology 22 5.051444e-286 2.1025487594545455e-283 2.299323 2198 0.1653129 9 4.314358195444444e-37 1.633809 475 849 0.07387247 Mouse Phenotype Single KO abnormal T cell morphology 23 3.560196e-285 1.4174223813913042e-282 2.278714 2229 0.1676444 38 2.721417024736842e-24 1.514577 431 831 0.06702955 Mouse Phenotype Single KO abnormal B cell physiology 25 4.495022e-262 1.64643665816e-259 2.61192 1624 0.122142 22 1.3774829315000001e-28 1.702562 316 542 0.04914463 Mouse Phenotype Single KO decreased lymphocyte cell number 27 1.108221e-249 3.7585109988888884e-247 2.17325 2165 0.1628309 47 9.449501856170213e-23 1.503265 418 812 0.06500778 Mouse Phenotype Single KO abnormal T cell number 29 3.270304e-243 1.0326266802758622e-240 2.217095 2032 0.1528279 53 6.165052186415095e-22 1.507454 398 771 0.06189736 Mouse Phenotype Single KO abnormal cytokine secretion 30 1.028014e-239 3.137841399333333e-237 2.572771 1531 0.1151474 32 2.6434799603125e-25 1.641664 321 571 0.04992224 Mouse Phenotype Single KO abnormal hemopoiesis 31 4.438604e-235 1.3111063492903227e-232 2.15482 2085 0.1568141 35 5.597878170285714e-25 1.557449 392 735 0.06096423 Mouse Phenotype Single KO abnormal blood cell morphology/development 33 2.430449e-228 6.744127725151514e-226 2.04209 2273 0.1709537 42 2.1001252464285713e-23 1.495804 440 859 0.06842924 Mouse Phenotype Single KO increased lymphocyte cell number 35 1.110929e-223 2.906507672285714e-221 2.324247 1718 0.1292118 49 1.0116373283673469e-22 1.58417 332 612 0.05163297 Mouse Phenotype abnormal immune cell physiology 1 0 0 2.214994 3776 0.2839952 1 7.6581678678e-55 1.56737 811 1511 0.1261275 Mouse Phenotype abnormal blood cell physiology 1 0 0 2.155265 3897 0.2930957 2 1.01159539035e-54 1.546533 850 1605 0.1321928 Mouse Phenotype abnormal cell-mediated immunity 1 0 0 2.213593 3791 0.2851233 3 6.922527318e-55 1.56269 815 1523 0.1267496 Mouse Phenotype abnormal leukocyte physiology 1 0 0 2.214819 3741 0.2813628 4 7.525164318750001e-55 1.570454 797 1482 0.1239502 Mouse Phenotype abnormal hematopoietic system physiology 1 0 0 2.097517 4089 0.3075361 5 9.3561919068e-55 1.525895 893 1709 0.1388802 Mouse Phenotype abnormal adaptive immunity 1 0 0 2.195766 3818 0.287154 6 1.9115323234999998e-54 1.554676 822 1544 0.1278383 Mouse Phenotype abnormal lymphocyte physiology 1 0 0 2.372409 3002 0.2257822 8 1.1917061059125001e-47 1.627399 608 1091 0.09455677 Mouse Phenotype abnormal professional antigen presenting cell physiology 1 0 0 2.260724 2631 0.1978791 9 1.1093936376666667e-42 1.613805 567 1026 0.0881804 Mouse Phenotype abnormal immune serum protein physiology 1 0 0 2.235733 2839 0.2135229 15 6.0029191054e-38 1.540806 611 1158 0.09502333 Mouse Phenotype abnormal lymphocyte morphology 1 0 0 2.080373 3564 0.2680505 18 2.2764337313333335e-37 1.474226 731 1448 0.1136858 Mouse Phenotype abnormal lymphocyte cell number 1 0 0 2.055375 3319 0.2496239 20 1.7396784477e-35 1.480704 683 1347 0.1062208 Mouse Phenotype abnormal T cell morphology 22 2.069796e-312 8.99514525271745e-310 2.14914 2704 0.2033694 54 1.0630755502222223e-27 1.482274 535 1054 0.08320373 Mouse Phenotype abnormal hemopoiesis 23 1.486624e-308 6.179831332173913e-306 2.150214 2672 0.2009627 41 1.5089757851707316e-29 1.512463 520 1004 0.08087092 Mouse Phenotype decreased lymphocyte cell number 24 5.508042e-308 2.1942662317500002e-305 2.111155 2766 0.2080325 43 6.042082843953488e-29 1.488632 548 1075 0.08522551 Mouse Phenotype abnormal B cell physiology 25 9.088139e-307 3.47566787916e-304 2.543232 1965 0.1477888 25 5.0449725576e-33 1.67241 386 674 0.0600311 Mouse Phenotype abnormal T cell physiology 27 2.073433e-304 7.342256634444445e-302 2.490983 2020 0.1519254 26 1.1610775435384615e-32 1.657307 395 696 0.06143079 Mouse Phenotype abnormal blood cell morphology/development 28 4.295768e-300 1.4668513517142857e-297 2.048029 2876 0.2163057 48 1.9857675128749996e-28 1.467767 575 1144 0.08942457 Mouse Phenotype abnormal definitive hematopoiesis 30 2.08448e-292 6.64323776e-290 2.136704 2580 0.1940433 38 3.3290420739473684e-30 1.525799 511 978 0.07947123 Mouse Phenotype abnormal leukopoiesis 31 2.869689e-286 8.850676299677419e-284 2.298594 2201 0.1655385 31 5.063348306129032e-31 1.612888 417 755 0.06485226 Mouse Phenotype abnormal humoral immune response 33 3.648304e-283 1.057013168e-280 2.584098 1777 0.1336492 52 9.59416196076923e-28 1.652677 339 599 0.05272162