# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process blood coagulation 31 4.59496e-22 1.9504864077419355e-19 2.007055 229 0.051693 252 0.009529491930555556 1.396261 96 306 0.02275421 GO Biological Process coagulation 32 5.190899e-22 2.13459499815625e-19 2.004996 229 0.051693 274 0.01134139151350365 1.387194 96 308 0.02275421 GO Biological Process production of molecular mediator of immune response 78 1.453374e-16 2.45191647e-14 3.03867 76 0.01715576 196 0.003950148513928572 1.963491 30 68 0.00711069 GO Biological Process platelet activation 90 1.217879e-15 1.780674417888889e-13 2.182341 130 0.02934537 127 0.0007077573330708661 1.736042 55 141 0.01303626 GO Biological Process platelet-derived growth factor receptor signaling pathway 92 1.648727e-15 2.3582172383695653e-13 3.218015 65 0.01467269 382 0.03073304085157068 2.157857 16 33 0.003792368 GO Biological Process cellular response to dexamethasone stimulus 111 1.692515e-14 2.0064689085585585e-12 3.440859 55 0.01241535 343 0.023171076941982508 2.161711 17 35 0.004029391 GO Biological Process regulation of intrinsic apoptotic signaling pathway 139 5.166241e-13 4.89083203733813e-11 2.219766 102 0.02302483 288 0.013084519146180555 1.550525 54 155 0.01279924 GO Biological Process response to dexamethasone 167 1.349847e-11 1.063630938502994e-9 2.765088 59 0.01331828 409 0.03907248140097799 1.935035 20 46 0.00474046 GO Biological Process chromatin assembly or disassembly 182 3.438299e-11 2.485965744010989e-9 2.058597 102 0.02302483 354 0.02501118863135593 1.475192 59 178 0.01398436 GO Biological Process cellular response to glucocorticoid stimulus 198 1.226585e-10 8.151834351010102e-9 2.272013 77 0.01738149 277 0.012118360627075811 1.928585 26 60 0.006162598 GO Biological Process cellular response to corticosteroid stimulus 211 2.273525e-10 1.41788225e-8 2.240335 77 0.01738149 348 0.02415169206235632 1.836748 26 63 0.006162598 GO Biological Process positive regulation of neuron death 247 7.556634e-10 4.025819708744939e-8 2.057326 88 0.01986456 169 0.0020602882785798818 1.939997 34 78 0.008058782 GO Biological Process face development 259 1.402815e-9 7.127275129343629e-8 2.322977 65 0.01467269 159 0.001483486072075472 2.22529 25 50 0.005925575 GO Biological Process placenta blood vessel development 273 2.320888e-9 1.1187020216849817e-7 2.967733 41 0.009255079 418 0.04155061284928229 2.153507 15 31 0.003555345 GO Biological Process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 335 2.099581e-8 8.247279516119404e-7 3.083009 34 0.007674944 418 0.04155061284928229 2.153507 15 31 0.003555345 GO Biological Process face morphogenesis 338 2.326752e-8 9.058499872189349e-7 2.552742 46 0.01038375 178 0.002611524790224719 2.503452 18 32 0.004266414 GO Biological Process head morphogenesis 345 2.661127e-8 0.0000010150078316811593 2.430471 50 0.01128668 188 0.0033479596764361703 2.342411 20 38 0.00474046 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 472 5.83434e-7 0.0000162656949279661 2.467929 39 0.008803612 364 0.027583364378846155 1.895618 23 54 0.005451529 GO Biological Process negative regulation of transcription from RNA polymerase II promoter in response to stress 546 0.000001971137 0.00004750584575641026 3.874301 18 0.004063205 316 0.017586066545886077 3.081171 9 13 0.002133207 GO Biological Process preganglionic parasympathetic fiber development 596 0.000004364828 0.00009637042223489933 2.544209 31 0.006997743 352 0.02499971866960227 2.781613 10 16 0.00237023 GO Cellular Component ficolin-1-rich granule lumen 47 1.83199e-10 6.735486638297872e-9 2.30947 73 0.01647856 34 0.01626774776470588 1.61513 45 124 0.01066603 GO Cellular Component transcription factor AP-1 complex 50 3.35219e-10 1.158516864e-8 10.01285 14 0.003160271 42 0.023518660114285717 4.450581 5 5 0.001185115 GO Cellular Component protein serine/threonine phosphatase complex 97 0.00000113999 0.000020308275463917528 2.115864 51 0.01151242 37 0.01911777003243243 1.99822 22 49 0.005214506 GO Molecular Function bHLH transcription factor binding 58 3.633247e-7 0.000026447532472413793 2.312617 46 0.01038375 32 0.0098309217225 2.543189 16 28 0.003792368 GO Molecular Function S100 protein binding 111 0.00003647758 0.0013874625473873875 3.751876 14 0.003160271 48 0.0371458156875 3.081171 9 13 0.002133207 Mouse Phenotype Single KO abnormal platelet activation 25 1.003344e-31 3.675048403200001e-29 3.694115 117 0.02641084 146 0.002081583665410959 1.884952 36 85 0.008532828 Mouse Phenotype Single KO abnormal T cell activation 28 1.029578e-30 3.3670877664285717e-28 2.243392 251 0.05665914 54 0.0000042074414025925925 1.632393 106 289 0.02512444 Mouse Phenotype Single KO abnormal platelet aggregation 32 2.890667e-30 8.2718242871875e-28 3.677055 112 0.02528217 208 0.008047488573076923 1.825879 32 78 0.007584736 Mouse Phenotype Single KO abnormal T cell proliferation 38 2.359499e-28 5.685771669210526e-26 2.24396 231 0.05214447 62 0.000014073170282741936 1.636995 96 261 0.02275421 Mouse Phenotype Single KO abnormal platelet physiology 45 1.821235e-26 3.7060108655555554e-24 2.961414 131 0.02957111 165 0.0034420863316363634 1.739772 43 110 0.01019199 Mouse Phenotype Single KO abnormal erythropoiesis 47 1.520176e-25 2.961755666382978e-23 2.703875 146 0.03295711 30 2.2866396445333335e-7 2.184831 54 110 0.01279924 Mouse Phenotype Single KO decreased T cell proliferation 60 1.646288e-22 2.5125098693333334e-20 2.434985 154 0.03476298 156 0.0031504664369871793 1.63188 55 150 0.01303626 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 65 4.60644e-22 6.489410935384615e-20 2.408017 154 0.03476298 85 0.00016916157017647057 1.703937 67 175 0.01588054 Mouse Phenotype Single KO abnormal neutrophil cell number 66 7.25917e-22 1.0071548437878788e-19 2.135351 196 0.04424379 178 0.005045382505955056 1.444778 87 268 0.020621 Mouse Phenotype Single KO decreased erythrocyte cell number 75 6.30292e-20 7.695445125333334e-18 2.154625 174 0.03927765 248 0.015268060566532259 1.500481 59 175 0.01398436 Mouse Phenotype Single KO decreased erythroid progenitor cell number 86 8.844565e-19 9.417404849418605e-17 2.99806 89 0.02009029 232 0.011098437932327586 2.007125 23 51 0.005451529 Mouse Phenotype Single KO decreased vascular endothelial cell number 88 1.30176e-18 1.3545700363636363e-16 6.847729 36 0.008126411 289 0.02298599328685121 3.814783 6 7 0.001422138 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 91 5.144408e-18 5.176631214945055e-16 2.036686 178 0.04018059 128 0.0013414539996093751 1.500579 88 261 0.02085802 Mouse Phenotype Single KO increased pre-B cell number 96 1.317445e-17 1.2566504026041667e-15 4.31185 52 0.01173815 323 0.0336955770619195 2.314302 13 25 0.003081299 Mouse Phenotype Single KO cortical renal glomerulopathies 114 4.762261e-16 3.8252652611403505e-14 2.243138 126 0.02844244 266 0.01989454639473684 1.561025 47 134 0.01114008 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 115 4.904602e-16 3.905342653391304e-14 2.294977 120 0.02708804 117 0.0006546257121794872 1.675836 61 162 0.0144584 Mouse Phenotype Single KO abnormal lymph node cortex morphology 120 2.912948e-15 2.2228220696666668e-13 3.212616 64 0.01444695 296 0.02590380419864865 1.947129 21 48 0.004977483 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 121 3.081992e-15 2.3323802267768593e-13 2.732104 82 0.01851016 346 0.03926373394219653 1.847411 22 53 0.005214506 Mouse Phenotype Single KO extramedullary hematopoiesis 123 4.656371e-15 3.4665357111382115e-13 2.481191 96 0.02167043 201 0.007365047991542289 1.678728 43 114 0.01019199 Mouse Phenotype Single KO joint inflammation 124 7.382964e-15 5.452080753870968e-13 2.448263 97 0.02189616 211 0.00829193690805687 1.637814 46 125 0.01090306 Mouse Phenotype abnormal T cell activation 26 3.192408e-34 1.1739466495384615e-31 2.068077 335 0.07562077 69 0.00000199212996 1.534308 141 409 0.03342024 Mouse Phenotype abnormal platelet activation 32 8.982309e-32 2.68374551090625e-29 3.577498 122 0.0275395 250 0.005405338120800001 1.735726 39 100 0.009243897 Mouse Phenotype abnormal T cell proliferation 34 1.830822e-31 5.148379159411764e-29 2.097058 298 0.06726862 104 0.00003950486606826924 1.499652 124 368 0.02939085 Mouse Phenotype abnormal platelet aggregation 36 2.315097e-31 6.148511782499999e-29 3.585627 120 0.02708804 256 0.006198795919921875 1.751824 37 94 0.008769851 Mouse Phenotype abnormal erythropoiesis 56 2.906548e-27 4.962411683571428e-25 2.559182 172 0.03882619 40 7.165400620500001e-8 2.031138 68 149 0.01611756 Mouse Phenotype thymus hypoplasia 58 9.812985e-27 1.6176198204310347e-24 2.167886 234 0.05282167 112 0.00010234828548214285 1.633241 80 218 0.01896184 Mouse Phenotype abnormal platelet physiology 60 3.667671e-26 5.8444337385000004e-24 2.804147 141 0.03182844 172 0.001096855152034884 1.719543 51 132 0.01208817 Mouse Phenotype decreased inflammatory response 61 4.413485e-26 6.917595095901639e-24 2.263416 208 0.0469526 393 0.02750478312977099 1.341069 91 302 0.02156909 Mouse Phenotype extramedullary hematopoiesis 70 1.810294e-23 2.4726029905714288e-21 2.411409 164 0.03702032 182 0.0016192567386263737 1.602209 63 175 0.01493245 Mouse Phenotype decreased T cell proliferation 71 3.095287e-23 4.168174508028169e-21 2.158565 204 0.04604966 228 0.003935027060131579 1.504422 72 213 0.01706566 Mouse Phenotype abnormal splenic cell ratio 75 4.465874e-22 5.6930961752e-20 3.361333 90 0.02031603 372 0.023381207036290326 1.824008 25 61 0.005925575 Mouse Phenotype abnormal mean corpuscular hemoglobin 80 1.0452e-21 1.24914465e-19 2.326472 162 0.03656885 106 0.00004970139729056603 1.717344 71 184 0.01682863 Mouse Phenotype decreased erythrocyte cell number 94 2.906822e-20 2.956609057659575e-18 2.015977 207 0.04672686 202 0.0024262504782178217 1.502793 78 231 0.01848779 Mouse Phenotype decreased erythroid progenitor cell number 118 2.963313e-17 2.401036914661017e-15 2.59222 103 0.02325056 281 0.008814942580782918 1.815368 31 76 0.007347713 Mouse Phenotype abnormal pro-B cell morphology 141 2.052575e-15 1.3918205372340425e-13 2.103883 139 0.03137698 313 0.014353119822364216 1.62923 41 112 0.009717943 Mouse Phenotype decreased susceptibility to autoimmune disorder 142 2.489425e-15 1.6761543961267605e-13 2.132006 134 0.03024831 214 0.0030741545848598133 1.52716 70 204 0.01659161 Mouse Phenotype abnormal spleen red pulp morphology 147 3.238095e-15 2.1060834214285714e-13 2.110731 136 0.03069977 148 0.00040451609059459454 1.705093 59 154 0.01398436 Mouse Phenotype atherosclerotic lesions 155 2.098851e-14 1.2946525426451613e-12 2.333175 103 0.02325056 453 0.044146577271523185 1.551579 38 109 0.009006874 Mouse Phenotype joint inflammation 156 2.321159e-14 1.4226026409615385e-12 2.219194 114 0.02573363 440 0.04089511319318182 1.455536 52 159 0.0123252 Mouse Phenotype abnormal embryonic hematopoiesis 163 8.245197e-14 4.836339172822086e-12 2.498821 86 0.01941309 459 0.04619966852287582 1.751048 24 61 0.005688552