# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	2.700227e-53	2.0901345348823532e-50	2.677999	325	0.01849218	237	3.7673023251054853e-7	1.473811	91	113	0.008869396	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	19	1.560774e-51	1.0809592140000001e-48	2.29842	419	0.02384068	300	0.00001617732369333333	1.357829	115	155	0.01120858	
GO Biological Process	endoplasmic reticulum unfolded protein response	21	4.391793e-49	2.7519811469999998e-46	2.645425	305	0.0173542	408	0.0006765835310294119	1.348507	84	114	0.008187135	
GO Biological Process	IRE1-mediated unfolded protein response	22	3.684301e-48	2.2037144026818183e-45	3.6577	185	0.01052632	750	0.030868873469333334	1.356811	43	58	0.004191033	
GO Biological Process	regulation of DNA-templated transcription in response to stress	23	9.247718e-48	5.2909009200869565e-45	2.46216	338	0.01923186	226	1.2746046125221238e-7	1.476397	96	119	0.009356725	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	24	1.039027e-46	5.696898455416667e-44	9.269958	77	0.004381223	702	0.024241633517094015	1.830117	11	11	0.001072125	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	25	8.914825e-46	4.692407287e-43	4.662944	133	0.007567568	502	0.00275422850498008	1.677607	22	24	0.00214425	
GO Biological Process	cellular response to topologically incorrect protein	27	8.436911e-45	4.111900438851852e-42	2.372878	340	0.01934566	326	0.00006597753066871166	1.35613	103	139	0.01003899	
GO Biological Process	liver regeneration	31	6.897669e-44	2.9279492377741935e-41	3.512204	177	0.01007112	742	0.02876837605121294	1.464094	28	35	0.002729045	
GO Biological Process	cellular response to unfolded protein	33	4.364258e-42	1.740280940060606e-39	2.402382	311	0.01769559	391	0.00045586242437340157	1.346119	89	121	0.008674464	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	40	2.767778e-38	9.1052976755e-36	2.419262	278	0.01581792	518	0.0034745933044401543	1.343384	69	94	0.006725146	
GO Biological Process	response to topologically incorrect protein	44	1.088733e-37	3.2560539879545456e-35	2.050945	392	0.02230441	319	0.00003526672226144201	1.321751	130	180	0.01267057	
GO Biological Process	nuclear-transcribed mRNA catabolic process	47	2.220607e-37	6.217227130425531e-35	2.04378	392	0.02230441	152	8.030623442302632e-11	1.44191	156	198	0.01520468	
GO Biological Process	response to unfolded protein	56	6.414592e-35	1.5073145737142856e-32	2.05105	362	0.02059744	355	0.0001955813273774648	1.315397	115	160	0.01120858	
GO Biological Process	response to cadmium ion	58	1.16203e-34	2.63640565e-32	2.976033	175	0.009957326	642	0.014023995181775701	1.388365	44	58	0.004288499	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	67	1.251074e-31	2.4571466814925373e-29	2.406115	230	0.01308677	159	2.6803807106918235e-10	1.550947	100	118	0.009746589	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	78	1.989331e-30	3.356103413974359e-28	2.481652	208	0.01183499	348	0.00015177987638793106	1.454708	62	78	0.006042885	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	80	2.842e-30	4.67473475e-28	3.20307	136	0.007738265	537	0.004343330113407822	1.670976	21	23	0.002046784	
GO Biological Process	protein targeting to ER	88	1.092966e-29	1.6343567720454546e-27	2.460376	206	0.01172119	177	4.744604579322035e-9	1.558317	86	101	0.008382066	
GO Biological Process	viral gene expression	111	1.196776e-25	1.4187725571171172e-23	2.169663	229	0.01302987	166	4.2638711344578314e-10	1.527499	106	127	0.01033138	
GO Cellular Component	mitochondrial ribosome	42	9.536906e-26	3.923755611428572e-24	2.695656	150	0.008534851	69	0.000006336994226086957	1.485624	69	85	0.006725146	
GO Cellular Component	proteasome complex	47	1.737864e-20	6.389423387234043e-19	2.361231	150	0.008534851	72	0.0000082871592	1.534069	57	68	0.005555556	
GO Cellular Component	endopeptidase complex	48	1.825902e-20	6.573247200000001e-19	2.359898	150	0.008534851	74	0.00002162987571891892	1.511836	57	69	0.005555556	
GO Cellular Component	catalytic step 2 spliceosome	51	2.888821e-19	9.788005270588236e-18	2.025556	198	0.011266	99	0.0012796672581818183	1.353524	71	96	0.006920078	
GO Cellular Component	large ribosomal subunit	55	1.864766e-18	5.858755723636364e-17	2.02942	188	0.01069701	61	2.993000813114754e-7	1.464094	92	115	0.008966862	
GO Cellular Component	peptidase complex	56	4.851287e-18	1.49696856e-16	2.053841	178	0.01012802	73	0.000021612720920547945	1.455775	70	88	0.006822612	
GO Cellular Component	mitochondrial large ribosomal subunit	60	2.359247e-16	6.7946313599999995e-15	2.721179	90	0.00512091	104	0.0018337220307692306	1.47127	41	51	0.003996101	
GO Cellular Component	intercellular bridge	88	1.246774e-12	2.448210763636364e-11	2.149995	107	0.006088193	175	0.043148209371428575	1.372588	33	44	0.003216374	
GO Cellular Component	proteasome accessory complex	112	2.985961e-10	4.606911257142857e-9	2.713464	53	0.003015647	125	0.009434427955200001	1.601352	21	24	0.002046784	
GO Cellular Component	zona pellucida receptor complex	125	1.433422e-9	1.9815625728e-8	6.367206	18	0.001024182	174	0.043052007724137926	1.830117	9	9	0.000877193	
GO Cellular Component	endoribonuclease complex	158	7.907758e-8	8.648484698734176e-7	2.174012	59	0.003357041	183	0.049561598950819664	1.451472	23	29	0.002241715	
GO Cellular Component	very-low-density lipoprotein particle	173	5.730563e-7	0.000005723938071676301	2.302378	45	0.002560455	177	0.04383131552542373	1.555599	17	20	0.00165692	
GO Cellular Component	ESCRT complex	189	0.000001198029	0.000010953408	2.134823	50	0.00284495	154	0.025249132051948054	1.50331	23	28	0.002241715	
GO Cellular Component	preribosome, large subunit precursor	203	0.000003699447	0.00003149085919211822	2.100505	47	0.002674253	117	0.006207875446153846	1.610503	22	25	0.00214425	
GO Cellular Component	mitochondrial small ribosomal subunit	210	0.000005742311	0.00004725101622857143	2.143527	43	0.002446657	154	0.025249132051948054	1.50331	23	28	0.002241715	
GO Cellular Component	proteasome regulatory particle	227	0.00001240484	0.00009442979524229075	2.116282	41	0.002332859	161	0.030366830906832298	1.568672	18	21	0.001754386	
GO Molecular Function	protein phosphatase 2A binding	11	1.501361e-29	5.762496492727273e-27	3.000744	146	0.008307255	131	0.026908875102290078	1.558989	23	27	0.002241715	
GO Molecular Function	unfolded protein binding	12	4.194941e-29	1.4759200751666665e-26	2.427577	207	0.01177809	67	0.0004516732148656717	1.38122	80	106	0.007797271	
GO Molecular Function	ribonucleoprotein complex binding	16	3.50928e-21	9.260112600000001e-19	2.002377	226	0.01285917	50	0.000026913265659999998	1.416351	89	115	0.008674464	
GO Molecular Function	SUMO transferase activity	19	1.877268e-19	4.1714871031578943e-17	3.493725	75	0.004267425	136	0.042855504132352944	1.637473	17	19	0.00165692	
GO Molecular Function	rRNA binding	22	4.010412e-18	7.696345210909092e-16	2.784808	97	0.005519203	78	0.0019702190338461542	1.464094	48	60	0.004678363	
GO Molecular Function	snRNA binding	25	1.207997e-16	2.0400653335999998e-14	3.062581	76	0.004324324	74	0.0014199607267567566	1.589312	33	38	0.003216374	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	46	1.90956e-13	1.7526439826086956e-11	2.42609	89	0.005064011	87	0.002810346153333333	1.640795	26	29	0.002534113	
GO Molecular Function	5S rRNA binding	192	2.282712e-7	0.000005019588575	3.326983	26	0.001479374	134	0.04074642747761194	1.830117	11	11	0.001072125	
Human Phenotype	Increased serum lactate	6	1.250352e-22	1.3905998160000001e-19	2.15644	203	0.0115505	28	1.0800288631428571e-7	1.537298	84	100	0.008187135	
Human Phenotype	Exercise intolerance	19	2.439883e-19	8.569125925789473e-17	2.394173	137	0.007795164	117	0.0044701793920512815	1.411805	54	70	0.005263158	
Human Phenotype	External ophthalmoplegia	36	9.165282e-15	1.6988868551666663e-12	2.42533	99	0.005633001	150	0.017510610402666663	1.544161	27	32	0.002631579	
Human Phenotype	Abnormal CSF metabolite level	51	1.112178e-12	1.4552085870588235e-10	2.128589	110	0.00625889	148	0.014865694591891892	1.394375	48	63	0.004678363	
Human Phenotype	Increased CSF lactate	55	1.904067e-12	2.3101525619999996e-10	2.179503	102	0.005803698	166	0.027504067921084337	1.388365	44	58	0.004288499	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	306	0.00001342031	0.00029265924388888887	2.179898	38	0.002162162	174	0.03444931647931035	1.715735	15	16	0.001461988	
Mouse Phenotype Single KO	extramedullary hematopoiesis	2	1.274152e-60	5.833704932e-57	2.579839	396	0.02253201	255	0.0343315608572549	1.268239	79	114	0.007699805	
Mouse Phenotype Single KO	pale liver	52	8.154832e-24	1.4360345504615385e-21	2.132709	220	0.01251778	239	0.02974453367615063	1.326835	58	80	0.005653021	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	89	4.87781e-19	5.0186636146067425e-17	2.400183	134	0.007624467	207	0.018593792798550723	1.610503	22	25	0.00214425	
Mouse Phenotype Single KO	small thyroid gland	200	4.977134e-13	2.2787808018999997e-11	2.424165	86	0.004893314	105	0.0008916197062857144	1.830117	19	19	0.001851852	
Mouse Phenotype	extramedullary hematopoiesis	6	3.776414e-56	6.017715709e-53	2.090328	564	0.03209104	230	0.008433558566086956	1.24448	119	175	0.01159844	
Mouse Phenotype	abnormal vitelline vein morphology	107	4.87781e-19	4.358573963551402e-17	2.400183	134	0.007624467	262	0.0153386502629771	1.610503	22	25	0.00214425	
Mouse Phenotype	abnormal stapedial artery morphology	248	2.664849e-12	1.0273637616532259e-10	2.480914	77	0.004381223	291	0.027328994836082476	1.647105	18	20	0.001754386	
Mouse Phenotype	absent stapedial artery	281	1.643524e-11	5.592075787900355e-10	2.433529	74	0.004210526	329	0.040117578209726446	1.637473	17	19	0.00165692