# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	14	7.932986e-41	7.456440198142857e-38	2.619102	256	0.01808548	441	0.0030990608721088433	1.349678	77	113	0.008122363	
GO Biological Process	endoplasmic reticulum unfolded protein response	17	6.246434e-38	4.835107353294118e-35	2.595363	241	0.01702579	257	0.000017181255719455255	1.45946	84	114	0.008860759	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	2.15506e-36	1.289019751818182e-33	2.405839	266	0.01879195	420	0.002306994836452381	1.348205	81	119	0.008544304	
GO Biological Process	IRE1-mediated unfolded protein response	26	3.039669e-35	1.5384232450384615e-32	3.485862	142	0.01003179	492	0.0053193305046747965	1.468447	43	58	0.004535865	
GO Biological Process	cellular response to topologically incorrect protein	29	7.021537e-34	3.1860829442413793e-31	2.313626	267	0.01886259	282	0.00005536000632624114	1.396462	98	139	0.01033755	
GO Biological Process	response to topologically incorrect protein	35	9.369487e-33	3.5226594123714286e-30	2.091747	322	0.02274815	179	1.4553986325139665e-7	1.430503	130	180	0.01371308	
GO Biological Process	cellular response to unfolded protein	36	3.598121e-32	1.3152131733055553e-29	2.349812	245	0.01730837	283	0.00005731348977031802	1.424137	87	121	0.009177215	
GO Biological Process	nuclear-transcribed mRNA catabolic process	44	6.985306e-31	2.0890827648636365e-28	2.052073	317	0.02239491	202	7.643496350990099e-7	1.390489	139	198	0.01466245	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	46	1.285879e-30	3.67845255673913e-28	2.077307	305	0.02154716	466	0.004241766940343348	1.290647	101	155	0.01065401	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	47	1.841502e-30	5.155813791063829e-28	2.398703	222	0.0156835	624	0.017903755813461538	1.327488	63	94	0.00664557	
GO Biological Process	response to unfolded protein	49	6.394587e-30	1.7172728639387757e-27	2.082308	296	0.02091134	188	2.6284528543617024e-7	1.448384	117	160	0.01234177	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	2.590784e-29	6.556178203076923e-27	2.519856	194	0.0137054	250	0.000010447335397199998	1.460344	87	118	0.009177215	
GO Biological Process	cellular response to epidermal growth factor stimulus	59	7.719001e-28	1.7215988840508475e-25	2.675174	165	0.01165666	525	0.007271345077523809	1.563708	30	38	0.003164557	
GO Biological Process	response to epidermal growth factor	62	2.489091e-27	5.282894914354838e-25	2.584109	172	0.01215118	479	0.0046645358382045934	1.556261	33	42	0.003481013	
GO Biological Process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	65	6.105863e-27	1.2361084802615386e-24	4.499477	79	0.005581067	787	0.04193025895552732	1.667955	16	19	0.001687764	
GO Biological Process	mitochondrial membrane organization	70	1.089048e-26	2.047254661714286e-24	2.063865	268	0.01893324	143	4.082034985804196e-9	1.565389	98	124	0.01033755	
GO Biological Process	protein targeting to ER	72	2.561112e-26	4.68078789e-24	2.535804	171	0.01208054	196	5.459173623367347e-7	1.549257	79	101	0.008333333	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	73	2.859022e-26	5.1536808901369864e-24	2.53314	171	0.01208054	586	0.013371403326279865	1.371251	54	78	0.005696203	
GO Biological Process	cotranslational protein targeting to membrane	82	3.989009e-24	6.40138651597561e-22	2.499806	160	0.01130343	219	0.0000018434250822374427	1.53605	76	98	0.008016878	
GO Biological Process	mitochondrial translational termination	84	7.53731e-24	1.1807555034523808e-21	2.662628	141	0.009961144	276	0.00004968976664855073	1.502597	66	87	0.006962025	
GO Cellular Component	ribosomal subunit	32	7.351325e-33	3.9697155e-31	2.239296	277	0.01956906	55	1.6770180305454546e-7	1.413254	132	185	0.01392405	
GO Cellular Component	mitochondrial ribosome	37	3.460285e-26	1.616046616216216e-24	2.945321	132	0.009325327	82	0.0004132998790243902	1.444743	62	85	0.006540084	
GO Cellular Component	large ribosomal subunit	42	5.548142e-23	2.282664137142857e-21	2.332109	174	0.01229248	72	0.00010200110399999999	1.412323	82	115	0.008649789	
GO Cellular Component	catalytic step 2 spliceosome	46	2.680565e-19	1.0069600695652174e-17	2.159302	170	0.01200989	75	0.00013628673792	1.444258	70	96	0.007383966	
GO Cellular Component	mitochondrial large ribosomal subunit	47	1.852969e-18	6.812617940425533e-17	3.115862	83	0.005863652	140	0.013580932114285713	1.436976	37	51	0.003902954	
GO Cellular Component	spliceosomal snRNP complex	48	1.964222e-18	7.0711992e-17	2.670992	106	0.00748852	87	0.0007675863393103448	1.501496	47	62	0.004957806	
GO Cellular Component	endopeptidase complex	51	4.757468e-18	1.6119420988235293e-16	2.422195	124	0.008760155	112	0.006424987885714286	1.406581	49	69	0.005168776	
GO Cellular Component	proteasome complex	52	1.117711e-17	3.7142396307692307e-16	2.404019	123	0.008689509	125	0.0082092248064	1.398138	48	68	0.005063291	
GO Cellular Component	peptidase complex	55	4.781207e-16	1.5021683083636367e-14	2.105958	147	0.01038502	104	0.0042408758769230765	1.372983	61	88	0.006434599	
GO Cellular Component	small nuclear ribonucleoprotein complex	64	9.233727e-14	2.49310629e-12	2.245612	107	0.007559166	135	0.01279147136	1.377876	48	69	0.005063291	
GO Cellular Component	PcG protein complex	66	2.56123e-13	6.705765818181818e-12	2.085419	122	0.008618863	136	0.012850259294117646	1.463993	34	46	0.003586498	
GO Cellular Component	cleavage furrow	72	7.916538e-13	1.8999691200000002e-11	2.049049	122	0.008618863	188	0.0434851935319149	1.371251	36	52	0.003797468	
GO Cellular Component	small ribosomal subunit	74	9.572254e-13	2.2352506637837834e-11	2.150154	108	0.007629813	109	0.005597810025688073	1.402993	51	72	0.005379747	
GO Cellular Component	spliceosomal tri-snRNP complex	75	1.068172e-12	2.461068288e-11	3.062726	56	0.003956199	186	0.04371893883870968	1.502597	22	29	0.002320675	
GO Cellular Component	very-low-density lipoprotein particle	80	4.719606e-12	1.019434896e-10	3.176286	50	0.003532321	66	0.00003001431272727273	1.980696	20	20	0.002109705	
GO Cellular Component	methylosome	81	5.591107e-12	1.1927694933333333e-10	5.005407	29	0.002048746	180	0.0335396544	1.815638	11	12	0.001160338	
GO Cellular Component	chylomicron	93	6.587904e-11	1.2240750658064515e-9	3.644213	37	0.002613917	139	0.01275745105035971	1.839218	13	14	0.001371308	
GO Cellular Component	U2 snRNP	110	1.234124e-9	1.9386966109090908e-8	3.265038	37	0.002613917	171	0.025341190736842104	1.667955	16	19	0.001687764	
GO Cellular Component	U1 snRNP	113	1.759132e-9	2.690070881415929e-8	2.870716	44	0.003108442	113	0.006420384	1.772202	17	19	0.001793249	
GO Cellular Component	mitochondrial nucleoid	128	2.048582e-8	2.7655857000000004e-7	2.151727	66	0.004662663	88	0.0008579539636363637	1.603421	34	42	0.003586498	
GO Molecular Function	structural constituent of ribosome	9	4.169392e-28	1.955908113777778e-25	2.184794	248	0.01752031	18	5.0437442788888886e-8	1.479409	121	162	0.01276371	
GO Molecular Function	unfolded protein binding	11	1.713907e-25	6.578286685454545e-23	2.489913	171	0.01208054	43	0.00009424990536744185	1.457493	78	106	0.008227848	
GO Molecular Function	ribonucleoprotein complex binding	12	2.292698e-24	8.066475796666666e-22	2.233155	203	0.01434122	55	0.0007970813592727274	1.395099	81	115	0.008544304	
GO Molecular Function	rRNA binding	18	1.018857e-16	2.389785696666667e-14	2.922959	82	0.005793006	79	0.013651281192405064	1.452511	44	60	0.00464135	
GO Molecular Function	ubiquitin-specific protease binding	204	0.000009127826	0.00018891020280392158	2.59066	28	0.0019781	81	0.015429637802469136	1.856903	15	16	0.001582278	
Human Phenotype	Increased serum lactate	1	1.570369e-24	1.0479072337e-20	2.374101	180	0.01271635	82	0.0007526768847195121	1.426101	72	100	0.007594937	
Human Phenotype	Abnormality of mitochondrial metabolism	26	1.52978e-14	3.926239207692308e-12	2.138644	127	0.008972095	88	0.0015224040020454547	1.492699	52	69	0.005485232	
Human Phenotype	Abnormality of the mitochondrion	29	3.47552e-14	7.997291365517241e-12	2.106121	128	0.009042741	91	0.0019523878065934067	1.478548	53	71	0.005590717	
Human Phenotype	External ophthalmoplegia	31	6.167443e-14	1.3275918431935485e-11	2.555056	84	0.005934299	106	0.004367035941603774	1.671212	27	32	0.002848101	
Human Phenotype	Dysphonia	80	2.016345e-9	1.681883773125e-7	2.442267	58	0.004097492	128	0.014940774014062502	1.722345	20	23	0.002109705	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	93	1.274777e-12	1.255175590215054e-10	2.827446	63	0.004450724	124	0.005291180448387096	1.800633	20	22	0.002109705	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	169	2.127816e-9	1.1529237344378699e-7	2.321248	64	0.004521371	145	0.010362831651034484	1.733109	21	24	0.00221519	
Mouse Phenotype Single KO	thin ventricle myocardium compact layer	272	5.62917e-7	0.000018950849150735292	2.137725	53	0.00374426	186	0.026668310180107523	1.980696	11	11	0.001160338	
Mouse Phenotype Single KO	decreased cellular sensitivity to gamma-irradiation	417	0.00001556351	0.00034176273637889684	2.11671	40	0.002825857	202	0.03894834300148515	1.69774	18	21	0.001898734	
Mouse Phenotype	extramedullary hematopoiesis	2	2.151624e-40	1.0285838532e-36	2.015557	438	0.03094313	256	0.007524521939062501	1.267646	112	175	0.01181435	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	49	1.161303e-17	2.2659628536734694e-15	2.499486	114	0.008053691	309	0.016737149334951455	1.627	23	28	0.00242616	
Mouse Phenotype	spleen atrophy	102	1.102689e-12	1.0336087773529412e-10	2.399965	85	0.006004945	278	0.010871960985971223	1.675974	22	26	0.002320675	
Mouse Phenotype	absent segment of posterior cerebral artery	104	1.274777e-12	1.1719368170192307e-10	2.827446	63	0.004450724	194	0.0035312025711340205	1.800633	20	22	0.002109705	
Mouse Phenotype	abnormal cerebral artery morphology	202	2.127816e-9	1.0071311275247525e-7	2.321248	64	0.004521371	238	0.006592036328571429	1.733109	21	24	0.00221519	
Mouse Phenotype	increased cardiac stroke volume	254	3.025484e-8	0.000001138844587559055	2.450994	49	0.003461674	268	0.009751156873880597	1.980696	12	12	0.001265823	
Mouse Phenotype	decreased abdominal adipose tissue amount	257	3.222567e-8	0.0000011988701590272373	2.396147	51	0.003602967	308	0.01660311419512987	1.663785	21	25	0.00221519	
Mouse Phenotype	decreased cellular sensitivity to gamma-irradiation	369	0.000001658507	0.00004297286023577236	2.209119	45	0.003179089	238	0.006592036328571429	1.733109	21	24	0.00221519