# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	13	2.184596e-37	2.2113152895384616e-34	2.91279	195	0.02011346	587	0.03660046950085179	1.367544	59	113	0.008229879	
GO Biological Process	rRNA processing	18	1.459378e-34	1.0668863945555555e-31	2.262846	284	0.02929345	189	0.00001564230521058201	1.413533	136	252	0.01897057	
GO Biological Process	rRNA metabolic process	21	8.988971e-34	5.632660447095237e-31	2.222865	288	0.02970603	206	0.00003126494718980583	1.395555	138	259	0.01924955	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	8.342742e-33	4.990097362636363e-30	2.641052	200	0.02062919	562	0.031680175427046264	1.364622	62	119	0.008648347	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	23	7.52294e-32	4.3041029330434785e-29	3.157751	146	0.01505931	511	0.020797129961839533	1.477494	44	78	0.006137537	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	24	2.117088e-31	1.160781708e-28	2.965088	158	0.01629706	370	0.003856582816216216	1.460258	63	113	0.008787837	
GO Biological Process	regulation of hematopoietic stem cell differentiation	26	1.488519e-29	7.533623661923077e-27	3.035575	143	0.01474987	429	0.009001124083916085	1.449457	57	103	0.0079509	
GO Biological Process	regulation of cellular amino acid metabolic process	27	3.686845e-29	1.7968590131481484e-26	3.960533	99	0.01021145	400	0.0062286613215	1.615169	37	60	0.00516111	
GO Biological Process	mRNA catabolic process	30	8.575861e-27	3.761658496633333e-24	2.128106	249	0.02568334	409	0.006821934466503667	1.315745	107	213	0.01492537	
GO Biological Process	regulation of stem cell differentiation	32	5.838445e-26	2.40087805484375e-23	2.108658	246	0.0253739	247	0.00013635425057894736	1.504643	81	141	0.01129865	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	2.495876e-25	9.659774201176471e-23	2.154916	228	0.02351728	386	0.00517077450492228	1.336053	101	198	0.01408844	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	47	1.451108e-22	4.062793653617021e-20	2.108137	212	0.02186694	379	0.004538344666226913	1.385638	82	155	0.01143814	
GO Biological Process	protein targeting to ER	48	2.227176e-22	6.105710205e-20	2.72805	126	0.01299639	265	0.00023942085444905663	1.581889	61	101	0.008508858	
GO Biological Process	cotranslational protein targeting to membrane	58	1.271157e-20	2.883992235e-18	2.691723	118	0.01217122	305	0.0008403130307540984	1.550135	58	98	0.008090389	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	62	2.604077e-20	5.526943426290323e-18	2.505025	132	0.01361527	264	0.00023036070632954545	1.571516	63	105	0.008787837	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	69	4.518859e-20	8.617922547971014e-18	2.72793	112	0.01155235	311	0.0008945839388745982	1.565822	55	92	0.007671921	
GO Biological Process	liver regeneration	71	6.534008e-20	1.2110001587605633e-17	3.165459	88	0.009076844	421	0.008080060465795723	1.796019	24	35	0.003347747	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	73	6.983841e-20	1.2589090920410959e-17	2.484319	131	0.01351212	599	0.04137016050584307	1.35399	61	118	0.008508858	
GO Biological Process	negative regulation of protein ubiquitination	74	7.583929e-20	1.3486070501486487e-17	2.131107	180	0.01856627	331	0.0015712478109063443	1.442455	76	138	0.0106012	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	83	4.22661e-19	6.700959155421686e-17	2.488465	125	0.01289324	402	0.006237009201243781	1.500886	51	89	0.007113963	
GO Cellular Component	ribosomal subunit	28	4.003684e-26	2.470844982857143e-24	2.337001	198	0.0204229	42	5.4129558857142855e-8	1.571516	111	185	0.01548333	
GO Cellular Component	large ribosomal subunit	32	8.188942e-22	4.42202868e-20	2.602635	133	0.01371841	48	3.9898512e-7	1.685394	74	115	0.01032222	
GO Cellular Component	mitochondrial ribosome	41	8.042146e-18	3.3894703141463414e-16	2.899418	89	0.00917999	58	0.00005586171144827586	1.663958	54	85	0.007532431	
GO Cellular Component	endopeptidase complex	45	3.208188e-16	1.2319441920000001e-14	2.65236	93	0.009592573	73	0.0025852300273972602	1.594292	42	69	0.005858558	
GO Cellular Component	proteasome complex	47	8.337032e-16	3.065189637446808e-14	2.625322	92	0.009489428	76	0.00402126972631579	1.57922	41	68	0.005719068	
GO Cellular Component	PcG protein complex	50	7.031759e-15	2.4301759104e-13	2.445804	98	0.0101083	88	0.010703813236363637	1.651231	29	46	0.004045195	
GO Cellular Component	nucleosome	52	1.88835e-14	6.275132307692307e-13	2.561036	87	0.008973698	117	0.030978417230769228	1.371959	55	105	0.007671921	
GO Cellular Component	mitochondrial large ribosomal subunit	53	2.889699e-14	9.42150919245283e-13	3.233808	59	0.006085611	56	0.00001988418857142857	1.900199	37	51	0.00516111	
GO Cellular Component	peptidase complex	57	5.438163e-13	1.6486220463157894e-11	2.196259	105	0.01083032	81	0.006203159466666667	1.488178	50	88	0.006974473	
GO Cellular Component	DNA packaging complex	62	2.576569e-12	7.181147148387097e-11	2.246631	94	0.009695719	93	0.012034291819354838	1.40314	60	112	0.008369368	
GO Cellular Component	catalytic step 2 spliceosome	65	1.231593e-11	3.274142621538462e-10	2.039949	110	0.01134605	101	0.01768214495049505	1.41873	52	96	0.007253452	
GO Cellular Component	spliceosomal snRNP complex	69	2.045972e-10	5.123825530434783e-9	2.428134	66	0.006807633	103	0.019406496932038834	1.520822	36	62	0.005021621	
GO Cellular Component	cytosolic large ribosomal subunit	77	5.472644e-10	1.2281466015584414e-8	2.2556	73	0.007529654	112	0.02769155485714286	1.502816	35	61	0.004882131	
GO Cellular Component	small-subunit processome	79	1.011023e-9	2.211452840506329e-8	2.882741	45	0.004641568	120	0.0383336352	1.64635	22	35	0.003068768	
GO Cellular Component	preribosome	89	7.162511e-9	1.3906538211235955e-7	2.04834	79	0.00814853	97	0.015098731348453609	1.481912	43	76	0.005998047	
GO Cellular Component	intercellular bridge	100	5.064048e-8	8.750674944000001e-7	2.185508	60	0.006188757	107	0.0245797018317757	1.607233	27	44	0.003766216	
GO Cellular Component	prespliceosome	124	0.000004431836	0.00006175977909677419	2.819241	26	0.002681795	116	0.030678301241379307	1.870853	15	21	0.002092342	
GO Cellular Component	Sin3-type complex	214	0.0005229995	0.00422309876635514	2.055059	27	0.002784941	89	0.01070757335730337	2.128095	13	16	0.001813363	
GO Molecular Function	structural constituent of ribosome	9	6.395503e-21	3.0002015184444443e-18	2.22519	173	0.01784425	18	0.000009376029955555556	1.552115	96	162	0.01339099	
GO Molecular Function	ribonucleoprotein complex binding	13	1.586571e-16	5.152694432307693e-14	2.200419	137	0.014131	81	0.022139365298765434	1.412087	62	115	0.008648347	
GO Molecular Function	rRNA binding	14	6.46651e-16	1.9501146585714284e-13	3.330819	64	0.006601341	69	0.011585131286956521	1.615169	37	60	0.00516111	
GO Molecular Function	nucleosomal DNA binding	109	0.000001379857	0.00005344730508256881	2.055197	54	0.005569881	83	0.027727939219277107	1.651231	29	46	0.004045195	
GO Molecular Function	quaternary ammonium group transmembrane transporter activity	462	0.004044072	0.03695686576623376	2.494984	12	0.001237751	82	0.02319072002195122	2.619194	8	8	0.001115916	
Human Phenotype	Increased serum lactate	11	6.264809e-12	3.800460950636364e-9	2.079757	108	0.01113976	57	0.011755683615789474	1.49294	57	100	0.0079509	
Mouse Phenotype Single KO	decreased trabecular bone thickness	69	7.199047e-10	9.55386570710145e-8	2.04626	90	0.009283136	211	0.03976445043222749	1.629721	28	45	0.003905705	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	101	2.773553e-8	0.000002514596516930693	2.033284	74	0.0076328	148	0.011714488228378377	1.615169	37	60	0.00516111	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	174	0.000002099951	0.000110512938545977	2.472846	35	0.003610108	228	0.04803392707017544	1.855262	17	24	0.002371321	
Mouse Phenotype Single KO	abnormal sublingual gland morphology	227	0.000009870848	0.00039818218121585907	3.078318	21	0.002166065	175	0.023568124390285713	2.619194	8	8	0.001115916	
Mouse Phenotype Single KO	endometrium hyperplasia	291	0.00004256629	0.0013394485138487973	2.413813	27	0.002784941	204	0.037108652725490195	2.216241	11	13	0.001534384	
Mouse Phenotype Single KO	increased hepatocyte proliferation	506	0.0007812976	0.01413901605375494	2.062339	25	0.002578649	149	0.011994754299999999	2.400928	11	12	0.001534384	
Mouse Phenotype	decreased Clara cell number	77	3.212526e-10	3.988955985194805e-8	2.676314	54	0.005569881	217	0.007571571793548388	2.619194	9	9	0.001255405	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	161	6.60406e-8	0.000003921827183850931	2.555458	43	0.004435276	198	0.004738938622727272	1.920742	22	30	0.003068768	
Mouse Phenotype	abnormal sublingual gland morphology	432	0.0001132483	0.0025064050840277775	2.271805	27	0.002784941	224	0.008330665763839286	2.400928	11	12	0.001534384