# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	12	3.082347e-41	3.38005034775e-38	2.948656	212	0.02036112	357	0.0035866653265266106	1.446876	65	113	0.008707301	
GO Biological Process	regulation of DNA-templated transcription in response to stress	15	3.492912e-35	3.0642152671999996e-32	2.643621	215	0.02064925	394	0.00616431017106599	1.416199	67	119	0.008975218	
GO Biological Process	mRNA catabolic process	23	1.530403e-30	8.755901337826087e-28	2.172552	273	0.02621975	113	4.5950110067256634e-9	1.558801	132	213	0.01768252	
GO Biological Process	RNA catabolic process	24	1.704024e-30	9.34302159e-28	2.072299	304	0.02919708	108	2.144849986574074e-9	1.534252	147	241	0.0196919	
GO Biological Process	nuclear-transcribed mRNA catabolic process	25	2.922828e-30	1.5384597460800001e-27	2.235337	254	0.02439493	122	1.5578799881147542e-8	1.562559	123	198	0.01647689	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	44	1.136528e-24	3.3989936254545456e-22	2.631092	149	0.01431041	219	0.0000223203018086758	1.577416	74	118	0.009912927	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	47	3.640738e-24	1.0193291774893619e-21	2.738909	136	0.01306185	399	0.006484962973684211	1.515653	47	78	0.006296048	
GO Biological Process	RNA phosphodiester bond hydrolysis	64	8.457002e-22	1.73883889559375e-19	2.27884	172	0.0165194	291	0.0007655544440549829	1.456248	77	133	0.0103148	
GO Biological Process	protein targeting to ER	79	6.427142e-20	1.0705666022531647e-17	2.540188	126	0.01210142	295	0.0009503599305762711	1.519165	61	101	0.008171467	
GO Biological Process	viral gene expression	81	1.244145e-19	2.0211980314814814e-17	2.334914	146	0.01402228	185	0.000002546027504108108	1.604271	81	127	0.01085064	
GO Biological Process	ribonucleoprotein complex export from nucleus	85	2.766956e-19	4.283573412235294e-17	2.283108	150	0.01440645	183	0.0000024920391957923498	1.609816	80	125	0.01071668	
GO Biological Process	ribonucleoprotein complex localization	92	1.137589e-18	1.6271232229347825e-16	2.231738	152	0.01459854	169	0.0000010058840823076922	1.624077	82	127	0.01098459	
GO Biological Process	protein localization to endoplasmic reticulum	98	5.545459e-18	7.446193365408164e-16	2.203467	150	0.01440645	337	0.0022733999921958456	1.440234	71	124	0.009511052	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	99	5.562481e-18	7.393604795858586e-16	2.203385	150	0.01440645	553	0.03774170149186257	1.391464	52	94	0.006965841	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	101	7.193299e-18	9.371942726831683e-16	2.332522	132	0.01267768	270	0.0004307266750777778	1.533159	64	105	0.008573342	
GO Biological Process	viral transcription	102	7.907346e-18	1.020125157e-15	2.312678	134	0.01286977	163	7.256590290245399e-7	1.669472	75	113	0.01004689	
GO Biological Process	regulation of telomere maintenance	103	8.313631e-18	1.0621268963980583e-15	2.148837	157	0.01507876	184	0.0000025337089521195653	1.773636	55	78	0.007367716	
GO Biological Process	multi-organism metabolic process	113	4.605463e-17	5.363122797964602e-15	2.047343	168	0.01613523	213	0.000016220592709389673	1.522892	89	147	0.0119223	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	126	4.269922e-16	4.459357428412698e-14	2.422919	109	0.01046869	323	0.0018350278461919506	1.614322	43	67	0.005760214	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	127	5.763261e-16	5.971555236141732e-14	2.523277	100	0.009604303	519	0.027334108061657033	1.467281	42	72	0.005626256	
GO Cellular Component	large ribosomal subunit	33	1.59099e-22	8.331002181818182e-21	2.56918	141	0.01354207	41	4.1250440897560974e-8	1.706056	78	115	0.01044876	
GO Cellular Component	ribosomal subunit	34	2.714477e-22	1.3795930164705882e-20	2.165078	197	0.01892048	56	0.0000013256821028571429	1.495607	110	185	0.01473543	
GO Cellular Component	mitochondrial large ribosomal subunit	42	2.421522e-19	9.96283337142857e-18	3.623549	71	0.006819055	53	6.461813615094341e-7	1.972814	40	51	0.005358339	
GO Cellular Component	outer mitochondrial membrane protein complex	45	2.739456e-17	1.051951104e-15	5.833504	38	0.003649635	130	0.0239740992	2.012271	12	15	0.001607502	
GO Cellular Component	mitochondrial ribosome	47	6.566018e-17	2.414059383829787e-15	2.760424	91	0.008739915	89	0.001008066466516854	1.538795	52	85	0.006965841	
GO Cellular Component	catalytic step 2 spliceosome	50	2.189095e-16	7.56551232e-15	2.244831	130	0.01248559	93	0.0014386620077419356	1.493482	57	96	0.007635633	
GO Cellular Component	endopeptidase complex	52	4.515708e-16	1.5006045046153847e-14	2.575935	97	0.009316174	84	0.0009554288914285716	1.603984	44	69	0.005894173	
GO Cellular Component	proteasome complex	53	1.138472e-15	3.711848332075472e-14	2.550819	96	0.009220131	92	0.0014190181982608695	1.590582	43	68	0.005760214	
GO Cellular Component	nuclear chromosome, telomeric region	55	5.159629e-15	1.6210616203636363e-13	2.081573	140	0.01344602	98	0.0036608896653061223	1.391058	73	132	0.009778969	
GO Cellular Component	ficolin-1-rich granule lumen	56	6.176081e-15	1.9057621371428573e-13	2.019065	150	0.01440645	110	0.007285951767272728	1.379379	68	124	0.009109176	
GO Cellular Component	peptidase complex	61	1.535291e-12	4.349152209836065e-11	2.122924	109	0.01046869	94	0.0014781411268085106	1.51492	53	88	0.007099799	
GO Cellular Component	spliceosomal snRNP complex	82	5.885092e-10	1.2401754848780489e-8	2.329439	68	0.006530926	142	0.032418715943661976	1.460519	36	62	0.004822505	
GO Cellular Component	small nuclear ribonucleoprotein complex	90	1.360223e-8	2.61162816e-7	2.08281	73	0.007011141	150	0.04043088	1.421713	39	69	0.00522438	
GO Cellular Component	spliceosomal tri-snRNP complex	97	3.16031e-8	5.629913072164948e-7	2.825396	38	0.003649635	105	0.006090628937142858	1.821452	21	29	0.002813128	
GO Cellular Component	ESCRT III complex	101	5.86316e-8	0.0000010031228198019802	3.812103	24	0.002305033	141	0.03253111965957447	2.096115	10	12	0.001339585	
GO Cellular Component	cytosolic large ribosomal subunit	108	9.139347e-8	0.00000146229552	2.013961	70	0.006723012	117	0.011303286646153847	1.525697	37	61	0.004956463	
GO Cellular Component	MLL1 complex	116	2.534681e-7	0.000003775800662068966	2.558393	39	0.003745678	157	0.048998111388535034	1.64798	19	29	0.002545211	
GO Cellular Component	ESCRT complex	137	0.000001369075	0.00001726833284671533	2.522441	35	0.003361506	139	0.03033532592805755	1.706837	19	28	0.002545211	
GO Cellular Component	Fanconi anaemia nuclear complex	147	0.000003598195	0.0000422971493877551	2.52807	32	0.003073377	125	0.017060433408	2.128363	11	13	0.001473543	
GO Cellular Component	prespliceosome	156	0.000005351735	0.00005928075692307692	2.726066	27	0.002593162	149	0.038232208751677856	1.79667	15	21	0.002009377	
GO Molecular Function	unfolded protein binding	8	2.269057e-21	1.19749483175e-18	2.593195	131	0.01258164	85	0.016015476512941176	1.423776	60	106	0.008037508	
GO Molecular Function	structural constituent of ribosome	9	2.546067e-20	1.1943883193333335e-17	2.155793	180	0.01728774	43	0.00008284921913023256	1.475044	95	162	0.01272605	
GO Molecular Function	ribonuclease activity	13	7.593477e-19	2.466127684153846e-16	2.348483	138	0.01325394	70	0.0068415399000000005	1.473633	58	99	0.007769591	
GO Molecular Function	exonuclease activity	16	7.328816e-17	1.933891322e-14	2.40967	116	0.01114099	87	0.022459807370114944	1.489345	45	76	0.006028131	
GO Molecular Function	ribonucleoprotein complex binding	18	1.565028e-15	3.6708601200000004e-13	2.108714	141	0.01354207	66	0.006068507052727273	1.443585	66	115	0.008841259	
GO Molecular Function	snRNA binding	28	1.601023e-11	2.4141139664285714e-9	3.19693	47	0.004514022	65	0.005940767756	1.787214	27	38	0.003616879	
GO Molecular Function	endoribonuclease activity, producing 3'-phosphomonoesters	94	0.000001282265	0.00005759279606382979	4.45049	16	0.001536688	91	0.03204364380659341	2.286671	10	11	0.001339585	
Human Phenotype	Increased serum lactate	18	1.095818e-13	4.062440841111111e-11	2.133779	119	0.01142912	44	0.0020843706970454547	1.534356	61	100	0.008171467	
Human Phenotype	Ependymoma	244	0.00017971	0.004914773893442623	3.396606	13	0.001248559	105	0.03957116963047619	2.515338	8	8	0.001071668	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	255	0.000009414846	0.00033808527381176467	2.302559	35	0.003361506	123	0.03650618956585366	1.886504	18	24	0.002411253	
Mouse Phenotype Single KO	heterochrony	317	0.00004518112	0.0013051215010725552	2.102907	36	0.003457549	116	0.03288401845862069	2.071455	14	17	0.001875419	
Mouse Phenotype Single KO	abnormal adrenal chromaffin cell morphology	343	0.0000851891	0.0022742757688046645	2.20105	30	0.002881291	127	0.04979830400314961	2.286671	10	11	0.001339585	
Mouse Phenotype Single KO	decreased embryonic cilium length	581	0.002532721	0.039917601027538725	2.27273	16	0.001536688	127	0.04979830400314961	2.286671	10	11	0.001339585	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	81	6.461698e-12	7.627196861481481e-10	2.988186	54	0.005186323	154	0.04791036346168832	1.760737	21	30	0.002813128	
Mouse Phenotype	heterochrony	325	0.00004518112	0.0013291590409846156	2.102907	36	0.003457549	131	0.030403366928244274	2.071455	14	17	0.001875419	
Mouse Phenotype	decreased embryonic cilium length	460	0.0004307748	0.008953560571304349	2.531466	18	0.001728774	117	0.02434408745128205	2.305727	11	12	0.001473543