# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	2	1.304024e-27	8.579825908e-24	2.670528	162	0.03457106	105	3.5523936140952384e-8	1.720608	108	252	0.02309173	
GO Biological Process	rRNA metabolic process	3	1.740947e-27	7.636373857666668e-24	2.634815	165	0.03521127	108	4.518549604259259e-8	1.705107	110	259	0.02351935	
GO Biological Process	nuclear-transcribed mRNA catabolic process	5	2.241531e-26	5.8992612858e-23	2.796257	143	0.03051643	74	3.5127185855405404e-12	2.007377	99	198	0.02116742	
GO Biological Process	ncRNA processing	6	2.266847e-26	4.971573278833334e-23	2.21297	221	0.04716176	135	0.0000033715941062962964	1.490325	147	396	0.0314304	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7	2.670379e-26	5.019931037285714e-23	3.727394	95	0.02027315	91	1.1916932112307694e-9	2.177493	64	118	0.01368399	
GO Biological Process	ribosome biogenesis	9	1.209234e-25	1.7680344673333337e-22	2.305784	197	0.04204012	96	4.596096017708333e-9	1.665563	134	323	0.02865084	
GO Biological Process	ribonucleoprotein complex biogenesis	10	2.550529e-25	3.3562411111e-22	2.003846	266	0.05676483	80	3.3896481933750005e-11	1.618282	183	454	0.03912765	
GO Biological Process	mRNA catabolic process	15	4.334364e-24	3.8023930583999996e-21	2.599302	147	0.03137004	79	1.5725996089240506e-11	1.941406	103	213	0.02202266	
GO Biological Process	RNA catabolic process	16	4.123441e-23	3.3912725074375e-20	2.423432	160	0.03414426	87	2.505930383678161e-10	1.83246	110	241	0.02351935	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	18	1.996651e-21	1.4596628060555555e-18	3.779392	75	0.01600512	120	5.52271057925e-7	2.138292	49	92	0.0104768	
GO Biological Process	cotranslational protein targeting to membrane	19	5.48388e-21	3.7980198378947366e-18	3.633998	77	0.01643192	124	7.439112736209678e-7	2.08931	51	98	0.01090443	
GO Biological Process	viral gene expression	24	3.576804e-19	1.9611318265e-16	3.091499	87	0.01856594	127	0.0000014160089057480314	1.928346	61	127	0.01304255	
GO Biological Process	viral transcription	25	4.350232e-19	2.28978811552e-16	3.182881	83	0.01771233	118	4.722317917033898e-7	2.025141	57	113	0.0121873	
GO Biological Process	negative regulation of gene expression, epigenetic	26	9.776742e-19	4.948159537615385e-16	3.192091	81	0.01728553	281	0.009252720411032029	1.619988	46	114	0.009835365	
GO Biological Process	protein targeting to ER	27	1.230323e-18	5.996229761851852e-16	3.359607	75	0.01600512	153	0.000020612515619607844	1.947751	49	101	0.0104768	
GO Biological Process	chromatin silencing	34	5.082475e-17	1.9670673095588234e-14	3.646425	61	0.0130175	426	0.040625725098591546	1.57279	38	97	0.008124866	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	39	3.7637e-16	1.269910982051282e-13	2.983989	76	0.01621852	158	0.000031268082660759496	1.911787	50	105	0.01069061	
GO Biological Process	multi-organism metabolic process	40	7.962287e-16	2.619393365825e-13	2.57239	95	0.02027315	139	0.000003566729909568345	1.829853	67	147	0.01432542	
GO Biological Process	protein localization to endoplasmic reticulum	42	3.352419e-15	1.0503448005e-12	2.709101	83	0.01771233	163	0.00005601280929815951	1.813114	56	124	0.01197349	
GO Biological Process	chromatin assembly or disassembly	50	1.893422e-13	4.9831080196e-11	2.156011	113	0.02411438	203	0.0009297099272906403	1.578835	70	178	0.01496686	
GO Cellular Component	ribosomal subunit	18	1.883884e-29	1.8085286399999997e-27	3.198973	131	0.02795561	18	5.652243839999999e-15	2.148435	99	185	0.02116742	
GO Cellular Component	ribosome	19	4.382882e-22	3.98611584e-20	2.488544	145	0.03094324	28	1.8816988114285715e-11	1.871283	110	236	0.02351935	
GO Cellular Component	large ribosomal subunit	21	2.118006e-19	1.7428163657142858e-17	3.279384	81	0.01728553	39	1.3863659815384614e-7	2.024832	58	115	0.01240111	
GO Cellular Component	cytosolic ribosome	23	3.841929e-16	2.886457961739131e-14	2.740781	87	0.01856594	32	3.899243879999999e-9	2.150761	60	112	0.01282874	
GO Cellular Component	cytosolic part	28	1.798714e-14	1.1100634971428574e-12	2.020443	143	0.03051643	34	3.366074371764706e-8	1.722998	103	240	0.02202266	
GO Cellular Component	mitochondrial ribosome	30	4.339433e-14	2.4995134080000002e-12	3.504852	52	0.01109688	43	0.000011881338195348837	2.030993	43	85	0.009193928	
GO Cellular Component	cytosolic large ribosomal subunit	31	9.067289e-14	5.054282384516129e-12	3.388135	53	0.01131029	42	0.00000269063712	2.303547	35	61	0.00748343	
GO Cellular Component	small ribosomal subunit	32	8.913267e-13	4.8131641800000004e-11	3.187346	53	0.01131029	36	7.7264784e-8	2.341939	42	72	0.008980115	
GO Cellular Component	mitochondrial small ribosomal subunit	40	2.819443e-9	1.217999376e-7	4.48709	24	0.005121639	44	0.00001162530850909091	2.867681	20	28	0.004276245	
GO Cellular Component	cytosolic small ribosomal subunit	63	0.000002741367	0.00007519178057142856	2.654915	30	0.006402049	57	0.002650850829473684	2.098621	23	44	0.004917682	
GO Cellular Component	preribosome, large subunit precursor	76	0.00005225185	0.0011880420631578948	3.017112	18	0.003841229	74	0.020392408216216216	2.248262	14	25	0.002993372	
GO Cellular Component	axon cytoplasm	89	0.0002800055	0.005436511280898877	2.107775	28	0.005975245	71	0.013054509430985918	2.007377	20	40	0.004276245	
GO Cellular Component	U1 snRNP	114	0.0007954245	0.012056960842105264	2.759136	14	0.002987623	79	0.04823410146835443	2.324331	11	19	0.002351935	
GO Molecular Function	structural constituent of ribosome	4	1.66292e-24	1.75521206e-21	3.060302	115	0.02454119	17	3.6141387917647063e-10	2.032159	82	162	0.01753261	
GO Molecular Function	rRNA binding	9	6.888987e-14	3.231700346e-11	4.307016	40	0.008536065	41	0.0074516209595121945	1.940464	29	60	0.006200556	
GO Molecular Function	protein transporter activity	10	2.925804e-11	1.2352744488e-8	2.410654	73	0.01557832	39	0.004507713565641025	1.756454	42	96	0.008980115	
Human Phenotype	Leukodystrophy	23	0.00006564042	0.019044283593913046	2.19917	31	0.00661545	92	0.02458581986847826	1.927081	24	50	0.005131495	
Mouse Phenotype Single KO	increased squamous cell carcinoma incidence	15	0.00000220676	0.0013471534213333333	2.931533	26	0.005548442	82	0.041294016352439025	2.316204	15	26	0.003207184	
Mouse Phenotype Single KO	thoracic vertebral transformation	49	0.0002184257	0.040818859895918366	2.050905	31	0.00661545	86	0.049231716095348835	1.923736	23	48	0.004917682	
Mouse Phenotype	abnormal cellular replicative senescence	1	4.952431e-17	4.7350192791e-13	2.998366	80	0.01707213	76	0.0048919661636842105	1.816198	38	84	0.008124866	
Mouse Phenotype	early cellular replicative senescence	2	2.351248e-15	1.1240141064e-11	3.007575	71	0.01515152	58	0.0027735818105172417	1.924882	35	73	0.00748343	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	5	3.925943e-8	0.000075071882046	3.442737	28	0.005975245	180	0.04124566532666667	2.141202	16	30	0.003420996	
Mouse Phenotype	increased adrenal gland tumor incidence	8	6.056542e-8	0.0000723832475775	4.26887	21	0.004481434	164	0.03501079044329269	2.597781	11	17	0.002351935	
Mouse Phenotype	sacral vertebral transformation	13	5.450097e-7	0.00040083367243846154	4.483135	17	0.003627828	138	0.02456258312608696	2.485323	13	21	0.00277956	
Mouse Phenotype	decreased DN4 thymocyte number	15	6.335276e-7	0.00040381049224	2.74913	32	0.006828852	93	0.00816124287032258	2.746936	13	19	0.00277956	
Mouse Phenotype	increased fibroblast apoptosis	22	0.000002767278	0.0012026338617272727	2.370184	37	0.00789586	148	0.029869765585135138	1.923736	23	48	0.004917682	
Mouse Phenotype	increased pheochromocytoma incidence	34	0.00001299415	0.0036540314161764707	4.421565	13	0.002774221	141	0.02565636034680851	3.011065	9	12	0.00192431