# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to epidermal growth factor stimulus	59	1.564126e-56	3.48853119220339e-54	2.812837	319	0.0122565	934	0.03963121671734476	1.353438	32	38	0.002739023	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	61	3.457269e-56	7.458066028032787e-54	2.381453	428	0.01644446	686	0.011014683403352769	1.237407	87	113	0.007446717	
GO Biological Process	mRNA catabolic process	62	5.349252e-56	1.1353355978709677e-53	2.00248	629	0.02416721	183	2.302172802568306e-7	1.297839	172	213	0.01472225	
GO Biological Process	nuclear-transcribed mRNA catabolic process	63	7.659563e-56	1.599876024079365e-53	2.059563	585	0.02247666	175	1.0654511445142859e-7	1.314988	162	198	0.0138663	
GO Biological Process	regulation of DNA-templated transcription in response to stress	75	5.687091e-53	9.978190729199999e-51	2.243033	456	0.01752027	556	0.0033800311535971224	1.256053	93	119	0.007960284	
GO Biological Process	response to epidermal growth factor	76	8.311358e-53	1.4390678937105263e-50	2.663702	326	0.01252545	919	0.036818309247007616	1.339339	35	42	0.002995806	
GO Biological Process	endoplasmic reticulum unfolded protein response	94	4.312885e-49	6.037580182446809e-47	2.313471	395	0.01517655	591	0.004696322412351946	1.254749	89	114	0.007617906	
GO Biological Process	cellular response to topologically incorrect protein	126	4.144014e-41	4.32786351e-39	2.045302	434	0.01667499	555	0.003370264112072072	1.237203	107	139	0.009158607	
GO Biological Process	cellular response to unfolded protein	129	1.812872e-40	1.8492699727131782e-38	2.096906	402	0.0154455	584	0.004425531680993151	1.248574	94	121	0.008045879	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	133	3.951414e-40	3.90952306962406e-38	2.480999	279	0.01071964	758	0.016344648074670187	1.295361	54	67	0.0046221	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	165	1.813842e-36	1.4465664774545453e-34	2.225207	315	0.01210282	259	0.00001032411954092664	1.348419	99	118	0.008473851	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	170	2.440713e-35	1.889255433352941e-33	2.296115	285	0.01095017	735	0.014453775776734692	1.277524	62	78	0.005306856	
GO Biological Process	protein-lipid complex subunit organization	184	5.234333e-34	3.7434015188586964e-32	2.594162	216	0.008299074	850	0.026603828961176468	1.33364	39	47	0.003338184	
GO Biological Process	plasma lipoprotein particle organization	224	8.038015e-31	4.721974972544642e-29	2.591811	195	0.00749222	808	0.022525846545792077	1.351515	37	44	0.003166995	
GO Biological Process	high-density lipoprotein particle remodeling	228	1.480158e-30	8.542718913157895e-29	4.383516	93	0.003573212	984	0.04737845795426829	1.512665	16	17	0.001369511	
GO Biological Process	cotranslational protein targeting to membrane	234	6.091582e-30	3.425603740940171e-28	2.209253	260	0.009989626	264	0.000012291398220075757	1.377606	84	98	0.007189934	
GO Biological Process	liver regeneration	243	3.634134e-29	1.9679658150617286e-27	2.545841	190	0.007300111	889	0.0320787704071991	1.377606	30	35	0.002567834	
GO Biological Process	regulation of plasma lipoprotein particle levels	245	3.6673e-29	1.969714314285714e-27	2.135585	273	0.01048911	570	0.0040412027750877195	1.320992	60	73	0.005135667	
GO Biological Process	protein targeting to ER	273	9.40966e-27	4.53559399047619e-25	2.096905	260	0.009989626	318	0.00004675115450628931	1.3526	85	101	0.007275529	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	282	2.949703e-26	1.3764234672695036e-24	2.159314	238	0.00914435	334	0.00006713962129041917	1.362632	78	92	0.006676367	
GO Cellular Component	high-density lipoprotein particle	45	3.063184e-36	1.176262656e-34	4.191916	117	0.004495332	90	0.000903134592	1.547681	26	27	0.002225456	
GO Cellular Component	protein-lipid complex	76	4.564012e-21	1.0377122021052631e-19	2.23394	174	0.006685365	122	0.010890507540983608	1.377606	36	42	0.0030814	
GO Cellular Component	plasma lipoprotein particle	78	1.014029e-20	2.246464246153846e-19	2.251556	168	0.006454835	132	0.01939749381818182	1.366126	34	40	0.002910211	
GO Cellular Component	cleavage furrow	80	1.764322e-20	3.8109355200000005e-19	2.000425	219	0.008414339	98	0.0017824073142857142	1.390852	45	52	0.00385175	
GO Cellular Component	proteasome complex	84	1.189671e-19	2.4473232e-18	2.06215	194	0.007453798	79	0.0005588957893670886	1.370853	58	68	0.004964478	
GO Cellular Component	endopeptidase complex	86	1.259643e-19	2.5310036093023257e-18	2.060985	194	0.007453798	94	0.0011569890178723405	1.350986	58	69	0.004964478	
GO Cellular Component	mitochondrial ribosome	100	9.160538e-18	1.5829409664000002e-16	2.075107	171	0.0065701	123	0.010884816702439024	1.266857	67	85	0.005734828	
GO Cellular Component	mitochondrial large ribosomal subunit	155	1.113394e-12	1.2412547303225807e-11	2.164172	106	0.004072694	161	0.04523292223602485	1.292068	41	51	0.003509373	
GO Cellular Component	U1 snRNP	246	5.669014e-8	3.982136663414634e-7	2.164478	61	0.00234372	133	0.019712023578947368	1.522617	18	19	0.0015407	
GO Molecular Function	ribonuclease activity	17	2.249546e-34	5.586813654117646e-32	2.15813	317	0.01217966	109	0.011694056866055045	1.266284	78	99	0.006676367	
GO Molecular Function	endoribonuclease activity	27	2.666056e-24	4.1689216414814815e-22	2.316383	188	0.007223268	110	0.013096125845454545	1.348906	47	56	0.004022939	
Human Phenotype	Leukodystrophy	73	1.503322e-15	1.3742010556164383e-13	2.018052	158	0.006070619	188	0.024315698556914893	1.350054	42	50	0.003594967	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	148	3.390837e-24	2.097965838445946e-22	2.953418	121	0.004649018	337	0.011353593115727003	1.534152	21	22	0.001797484	
Mouse Phenotype Single KO	abnormal mesangial matrix morphology	177	3.65962e-22	1.8932847649717515e-20	2.04036	227	0.008721712	412	0.024550917157766992	1.390017	32	37	0.002739023	
Mouse Phenotype Single KO	expanded mesangial matrix	206	5.064038e-20	2.251038639126213e-18	2.002859	213	0.008183809	352	0.01394055956875	1.423526	31	35	0.002653428	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	262	1.520254e-17	5.313345754961832e-16	2.406507	122	0.00468744	424	0.028557054754716982	1.473273	22	24	0.001883078	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	320	9.388531e-16	2.6865868239687506e-14	2.692219	88	0.003381104	481	0.04419514681081081	1.517918	17	18	0.001455106	
Mouse Phenotype Single KO	decreased red blood cell distribution width	727	1.141589e-8	1.4378996524071527e-7	2.363693	56	0.002151612	463	0.04131828264362851	1.607207	13	13	0.001112728	
Mouse Phenotype	decreased fibroblast cell migration	160	1.95694e-30	1.16939395875e-28	2.024296	325	0.01248703	514	0.010249105542023346	1.382946	37	43	0.003166995	
Mouse Phenotype	absent segment of posterior cerebral artery	228	3.390837e-24	1.4219207261842108e-22	2.953418	121	0.004649018	480	0.0083228505	1.534152	21	22	0.001797484	
Mouse Phenotype	heterochrony	285	6.850569e-21	2.298185621368421e-19	2.734094	117	0.004495332	778	0.04353884001670951	1.512665	16	17	0.001369511	
Mouse Phenotype	abnormal cerebral artery morphology	362	1.520254e-17	4.015234390607735e-16	2.406507	122	0.00468744	622	0.02032539480385852	1.473273	22	24	0.001883078	
Mouse Phenotype	abnormal pharyngeal muscle morphology	396	1.935206e-16	4.672349637878788e-15	3.243362	69	0.002651093	768	0.041816988027343745	1.607207	12	12	0.001027133	
Mouse Phenotype	absent ductus venosus valve	408	5.09213e-16	1.1932807580882352e-14	2.22354	130	0.004994813	736	0.037679277456521734	1.461097	20	22	0.001711889	
Mouse Phenotype	abnormal hypoglossal nerve topology	426	9.388531e-16	2.1071301617605635e-14	2.692219	88	0.003381104	712	0.031173801640449438	1.517918	17	18	0.001455106	
Mouse Phenotype	decreased red blood cell distribution width	907	1.141589e-8	1.2033883604189638e-7	2.363693	56	0.002151612	693	0.028823062441558443	1.607207	13	13	0.001112728	
Mouse Phenotype	decreased creatinine clearance	1102	2.854041e-7	0.0000024761784029945555	2.104647	58	0.002228455	778	0.04353884001670951	1.512665	16	17	0.001369511