# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	35	4.047615e-102	1.521787593857143e-99	2.043797	1103	0.0313041	425	0.0002438280340141176	1.148959	215	248	0.01517504	
GO Biological Process	regulation of DNA-templated transcription in response to stress	124	5.713593e-55	6.063320184435484e-53	2.071073	570	0.0161771	814	0.03358399888697789	1.147118	103	119	0.007269904	
GO Biological Process	multi-organism metabolic process	125	8.988528e-55	9.46240319616e-53	2.063459	573	0.01626224	215	3.848784103023256e-8	1.253185	139	147	0.009810841	
GO Biological Process	endoplasmic reticulum unfolded protein response	135	9.262678e-53	9.028709614962962e-51	2.154498	498	0.01413367	445	0.0004030743639775281	1.209055	104	114	0.007340486	
GO Biological Process	viral gene expression	142	1.645419e-50	1.524793564859155e-48	2.183332	462	0.01311196	232	1.0862278053448275e-7	1.262697	121	127	0.008540373	
GO Biological Process	cotranslational protein targeting to membrane	143	4.27169e-50	3.9308509587412585e-48	2.385094	380	0.01078473	254	2.890587277125984e-7	1.28474	95	98	0.006705251	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	149	1.758111e-47	1.552683399261745e-45	2.207242	423	0.01200511	295	0.000003828497302711864	1.24669	111	118	0.007834557	
GO Biological Process	viral transcription	158	3.495387e-45	2.9111264261392405e-43	2.157301	423	0.01200511	260	4.19339725626923e-7	1.266668	108	113	0.007622812	
GO Biological Process	organelle transport along microtubule	161	2.053944e-44	1.6787483910559006e-42	2.167711	411	0.01166454	374	0.00007209626103743316	1.28515	64	66	0.004517222	
GO Biological Process	protein targeting to ER	171	1.281882e-41	9.86449429122807e-40	2.20423	370	0.01050092	239	1.43511778707113e-7	1.285945	98	101	0.006916996	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	175	9.330687e-41	7.016143441885715e-39	2.271896	339	0.009621115	280	0.0000011911470404285714	1.282094	89	92	0.006281762	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	212	2.171719e-35	1.3480023736320756e-33	2.015575	386	0.01095502	258	4.141567262674419e-7	1.274823	101	105	0.007128741	
GO Biological Process	protein refolding	214	2.201345e-35	1.35362144182243e-33	4.937405	96	0.002724564	851	0.04159499594359577	1.325311	21	21	0.001482213	
GO Biological Process	mitochondrial transmembrane transport	246	1.374879e-32	7.354484862195121e-31	2.05803	336	0.009535973	643	0.010039917932348366	1.19757	75	83	0.005293619	
GO Biological Process	axonal transport	302	3.868755e-27	1.685726723344371e-25	2.256256	224	0.006357315	586	0.005161137199488054	1.291328	38	39	0.002682101	
GO Biological Process	anterograde axonal transport	303	5.670264e-27	2.462541385346534e-25	2.629911	165	0.004682844	561	0.003757591152941177	1.325311	31	31	0.002188029	
GO Biological Process	cytoplasmic translation	315	3.82007e-26	1.5958190834920633e-24	2.607811	162	0.004597701	534	0.0020052729034456926	1.294489	42	43	0.002964427	
GO Biological Process	mitochondrial translational termination	323	1.314736e-25	5.356226323219814e-24	2.033115	268	0.007606074	298	0.000003912542066409396	1.27961	84	87	0.005928854	
GO Biological Process	tRNA modification	328	2.007765e-25	8.05493281554878e-24	2.026861	268	0.007606074	507	0.0013412465180078896	1.236957	70	75	0.004940711	
GO Biological Process	gene silencing by miRNA	354	1.736982e-24	6.456764445762711e-23	2.107573	234	0.006641124	520	0.0015864452441346154	1.29519	43	44	0.003035008	
GO Cellular Component	ribosomal subunit	46	2.273067e-56	8.538825600000001e-55	2.020029	622	0.0176529	48	6.101182799999999e-10	1.246508	174	185	0.0122812	
GO Cellular Component	ficolin-1-rich granule lumen	60	4.139124e-45	1.1920677120000002e-43	2.0047	504	0.01430396	93	0.000034710261677419355	1.218431	114	124	0.008046302	
GO Cellular Component	large ribosomal subunit	75	6.93609e-35	1.598075136e-33	2.024525	376	0.01067121	52	2.4023652923076926e-9	1.290737	112	115	0.007905138	
GO Cellular Component	mitochondrial ribosome	89	4.986042e-30	9.680764692134832e-29	2.249925	251	0.007123599	89	0.00001978746391011236	1.262943	81	85	0.005717109	
GO Cellular Component	axon cytoplasm	94	1.608546e-27	2.956986689361702e-26	2.262574	226	0.006414077	147	0.0020857712326530615	1.292178	39	40	0.002752682	
GO Cellular Component	intrinsic component of mitochondrial membrane	102	4.711262e-26	7.981432094117647e-25	2.024284	276	0.00783312	138	0.0012820407652173913	1.243753	61	65	0.004305477	
GO Cellular Component	mitochondrial intermembrane space	107	1.386158e-25	2.2385803962616824e-24	2.011675	275	0.00780474	105	0.00008681870262857142	1.257346	74	78	0.005223038	
GO Cellular Component	small ribosomal subunit	115	2.581946e-24	3.8796545113043476e-23	2.031492	254	0.007208741	203	0.030374528630541874	1.178054	64	72	0.004517222	
GO Cellular Component	cytoplasmic stress granule	121	2.751472e-22	3.929374889256198e-21	2.039305	229	0.00649922	134	0.0010493751976119402	1.294489	42	43	0.002964427	
GO Cellular Component	mitochondrial large ribosomal subunit	144	8.945431e-18	1.07345172e-16	2.216935	147	0.004171988	114	0.00015120278905263158	1.299324	50	51	0.00352908	
GO Cellular Component	DNA-directed RNA polymerase III complex	158	2.027501e-15	2.2174188151898735e-14	3.289344	63	0.001787995	209	0.039090782928229664	1.325311	19	19	0.00134105	
GO Cellular Component	intraciliary transport particle B	164	6.509672e-15	6.858971473170733e-14	2.669716	84	0.002383993	192	0.024209748000000003	1.325311	21	21	0.001482213	
GO Cellular Component	intraciliary transport particle	175	1.029769e-13	1.0168233325714285e-12	2.180927	114	0.003235419	140	0.0014911245257142856	1.325311	32	32	0.002258611	
GO Cellular Component	INO80-type complex	199	7.740987e-12	6.721821877386935e-11	2.512726	72	0.002043423	181	0.014610115889502763	1.325311	23	23	0.001623377	
GO Cellular Component	MLL1 complex	201	1.020909e-11	8.776769910447761e-11	2.074179	107	0.003036753	193	0.026359905823834198	1.27961	28	29	0.001976285	
GO Cellular Component	preribosome, large subunit precursor	225	2.191454e-10	1.683036672e-9	2.073146	93	0.002639421	172	0.008746097190697676	1.325311	25	25	0.00176454	
GO Molecular Function	ribonucleoprotein complex binding	11	1.006266e-57	3.862231865454546e-55	2.231772	505	0.01433234	79	0.00016600636784810125	1.221591	106	115	0.007481649	
GO Molecular Function	unfolded protein binding	12	3.262759e-52	1.1479473748333333e-49	2.363225	404	0.01146587	101	0.002642872929306931	1.200281	96	106	0.006775833	
GO Molecular Function	rRNA binding	17	1.603226e-37	3.981658924705883e-35	2.87833	201	0.005704555	141	0.036184067106382986	1.214868	55	60	0.003881988	
GO Molecular Function	mitogen-activated protein kinase binding	57	2.77993e-18	2.0590990280701756e-16	2.176557	158	0.004484178	129	0.016207197590697674	1.325311	27	27	0.001905703	
GO Molecular Function	snRNA binding	147	1.275724e-11	3.6640181823129247e-10	2.090395	104	0.002951611	120	0.010468491219999999	1.290434	37	38	0.002611519	
Human Phenotype	Abnormal mitochondria in muscle tissue	131	4.577394e-10	2.3316755848854962e-8	2.14128	83	0.002355612	244	0.04185234494262295	1.325311	23	23	0.001623377	
Mouse Phenotype Single KO	decreased mean corpuscular hemoglobin	69	1.944365e-38	2.58036960942029e-36	2.067806	395	0.01121044	257	0.024768127953696498	1.210066	63	69	0.00444664	
Mouse Phenotype Single KO	abnormal platelet volume	98	1.233334e-29	1.1524121875510205e-27	2.003549	325	0.009223783	182	0.006305374354395605	1.255557	54	57	0.003811406	
Mouse Phenotype Single KO	increased susceptibility to weight loss	151	1.864449e-23	1.1306463240397352e-21	2.192335	204	0.005789698	274	0.03234299187591241	1.260661	39	41	0.002752682	
Mouse Phenotype Single KO	abnormal erythrocyte osmotic lysis	263	7.494806e-17	2.6095033666159694e-15	2.172374	145	0.004115226	214	0.012052272241121495	1.325311	29	29	0.002046866	
Mouse Phenotype	increased susceptibility to weight loss	164	1.365429e-26	7.960284554268292e-25	2.066586	268	0.007606074	326	0.014544357438036809	1.247351	48	51	0.003387916	
Mouse Phenotype	abnormal erythrocyte osmotic lysis	251	1.054081e-19	4.0151667095617525e-18	2.233359	162	0.004597701	241	0.002725580453651453	1.325311	34	34	0.002399774	
Mouse Phenotype	hemolysis	277	1.305193e-18	4.505036199638989e-17	2.131846	169	0.004796367	330	0.014420560778181818	1.288496	35	36	0.002470356	
Mouse Phenotype	interstitial pneumonia	407	2.220676e-13	5.216678927764128e-12	2.008836	135	0.003831418	431	0.045008862257540604	1.325311	22	22	0.001552795