# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	liver regeneration	14	3.334607e-30	3.1342923937857144e-27	3.919698	104	0.0112396	598	0.0368016960819398	1.698473	22	35	0.003165923	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	17	2.670785e-29	2.0673446950000003e-26	2.333867	224	0.02420836	318	0.000779585506163522	1.446939	83	155	0.01194416	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	34	1.107529e-23	4.286462973823529e-21	2.528962	153	0.01653518	539	0.02394231954953618	1.437295	50	94	0.00719528	
GO Biological Process	regulation of mRNA stability	53	9.622514e-20	2.389106825018868e-17	2.002179	208	0.0224792	151	4.3747069356291394e-7	1.628427	91	151	0.01309541	
GO Biological Process	NIK/NF-kappaB signaling	58	1.985614e-19	4.5049473493103455e-17	2.593463	118	0.01275262	408	0.0064173540279411755	1.5259	48	85	0.006907469	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	59	4.227959e-19	9.429781776440678e-17	2.477515	126	0.01361721	638	0.04867677040595611	1.363014	57	113	0.008202619	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	71	5.674679e-18	1.0517338163521127e-15	2.222152	147	0.01588674	603	0.03837463368988391	1.351058	64	128	0.009209958	
GO Biological Process	translational elongation	74	1.166123e-17	2.0736503455405405e-15	2.419568	121	0.01307684	363	0.00205878463862259	1.495814	62	112	0.008922147	
GO Biological Process	DNA-dependent DNA replication	101	3.034597e-16	3.953689299306931e-14	2.04693	159	0.01718362	98	6.412664021326531e-10	1.856236	79	115	0.01136854	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	108	7.703534e-16	9.386185546851852e-14	2.357031	113	0.01221226	336	0.0012385477949404763	1.578764	52	89	0.007483091	
GO Biological Process	negative regulation of cell cycle G2/M phase transition	110	9.543024e-16	1.141605934690909e-13	2.329247	115	0.0124284	294	0.0005392978929931973	1.603453	54	91	0.007770902	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	121	7.857304e-15	8.544980440991736e-13	2.265198	114	0.01232033	512	0.019868979709374998	1.396856	61	118	0.008778241	
GO Biological Process	cellular protein complex disassembly	125	1.910647e-14	2.01137630984e-12	2.055986	138	0.01491408	436	0.00900673791238532	1.415394	66	126	0.009497769	
GO Biological Process	DNA-templated transcription, elongation	140	9.303079e-14	8.744229754357144e-12	2.196508	112	0.01210418	390	0.004393229998974359	1.473881	60	110	0.008634336	
GO Biological Process	positive regulation of ubiquitin protein ligase activity	143	1.196941e-13	1.1014368265034966e-11	2.305878	100	0.01080731	361	0.0020439265959556786	1.576234	49	84	0.007051374	
GO Biological Process	regulation of ubiquitin protein ligase activity	149	1.939534e-13	1.7129079131543623e-11	2.254926	103	0.01113152	383	0.003658425325065274	1.527283	52	92	0.007483091	
GO Biological Process	protein targeting to ER	161	7.011155e-13	5.730421654968944e-11	2.245857	99	0.01069923	620	0.043338190187096774	1.391188	52	101	0.007483091	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	163	7.935326e-13	6.40619354809816e-11	2.413434	85	0.00918621	543	0.024657930353591158	1.501175	40	72	0.005756224	
GO Biological Process	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	168	1.444309e-12	1.1312894125595238e-10	2.399243	84	0.009078137	588	0.034879630323129254	1.484261	39	71	0.005612318	
GO Biological Process	regulation of mitochondrial membrane permeability	171	1.943251e-12	1.495394146725146e-10	2.122041	108	0.01167189	223	0.00003355471828878924	1.776733	48	73	0.006907469	
GO Cellular Component	PcG protein complex	31	2.463088e-22	1.3729729238709678e-20	2.928726	112	0.01210418	69	0.00236850048	1.762249	30	46	0.004317168	
GO Cellular Component	mitochondrial ribosome	32	4.637321e-22	2.5041533399999998e-20	3.242721	95	0.01026694	106	0.031689384452830184	1.430532	45	85	0.006475752	
GO Cellular Component	endopeptidase complex	36	9.594315e-20	4.6052712e-18	2.92847	98	0.01059116	75	0.007256823552	1.566444	40	69	0.005756224	
GO Cellular Component	peptidase complex	37	2.447955e-19	1.143261145945946e-17	2.586078	118	0.01275262	84	0.012118904228571429	1.473881	48	88	0.006907469	
GO Cellular Component	proteasome complex	41	6.723609e-18	2.833755207804878e-16	2.810528	94	0.01015887	82	0.010582914731707317	1.549743	39	68	0.005612318	
GO Cellular Component	ribosomal subunit	44	2.540598e-17	9.977621236363635e-16	2.065264	167	0.0180482	88	0.014799895854545454	1.314543	90	185	0.0129515	
GO Cellular Component	mitochondrial large ribosomal subunit	50	3.337621e-16	1.1534818176e-14	3.503138	61	0.006592457	94	0.02285274485106383	1.58948	30	51	0.004317168	
GO Cellular Component	spliceosomal snRNP complex	75	5.121049e-10	1.1798896896000002e-8	2.42848	63	0.006808603	117	0.04649079138461539	1.481805	34	62	0.00489279	
GO Cellular Component	cytoplasmic exosome (RNase complex)	82	1.809345e-9	3.812863609756098e-8	5.882083	19	0.002053388	86	0.012177246139534881	2.286405	11	13	0.001582962	
GO Cellular Component	prespliceosome	113	5.791679e-8	8.856656028318585e-7	3.294748	29	0.003134119	97	0.025390946969072164	1.930082	15	21	0.002158584	
GO Cellular Component	cytoplasmic stress granule	128	5.151846e-7	0.0000069549921	2.03465	60	0.006484383	98	0.02620512	1.633837	26	43	0.003741546	
GO Cellular Component	U2-type prespliceosome	138	0.000001161358	0.000014542221913043477	3.313908	23	0.00248568	110	0.03567320901818182	2.026587	12	16	0.001726867	
GO Cellular Component	exosome (RNase complex)	183	0.0000504426	0.00047631045245901635	2.435691	26	0.002809899	77	0.007913928062337662	1.997216	17	23	0.002446395	
GO Cellular Component	Golgi transport complex	198	0.000110823	0.0009671825454545455	2.525419	22	0.002377607	104	0.031182408	2.123091	11	14	0.001582962	
GO Molecular Function	NF-kappaB binding	15	1.22538e-15	3.44903624e-13	3.532587	58	0.006268237	67	0.0030394196904477613	2.026587	21	28	0.003022018	
GO Molecular Function	ribonuclease activity	23	4.041453e-12	7.418701985217392e-10	2.087307	109	0.01177996	63	0.0016407261634920633	1.555763	57	99	0.008202619	
GO Molecular Function	ribonucleoprotein complex binding	25	5.710557e-12	9.6439886616e-10	2.002613	119	0.01286069	45	0.00001550761240888889	1.644766	70	115	0.01007339	
GO Molecular Function	L-serine transmembrane transporter activity	38	6.66102e-10	7.400743800000001e-8	5.300428	22	0.002377607	65	0.003117405284923077	2.702115	10	10	0.001439056	
GO Molecular Function	exonuclease activity	43	1.796247e-9	1.763663914883721e-7	2.033623	87	0.009402356	85	0.008339488115294119	1.564383	44	76	0.006331846	
GO Molecular Function	3'-5'-exoribonuclease activity	139	0.00001121273	0.0003405765903597123	2.171709	39	0.004214849	102	0.038398427725490195	1.80141	20	30	0.002878112	
Human Phenotype	Progressive external ophthalmoplegia	24	4.898291e-13	1.3619289934583335e-10	4.570338	35	0.003782557	128	0.04470371468046875	2.161692	12	15	0.001726867	
Human Phenotype	Increased serum lactate	32	1.951861e-11	4.0702401415625e-9	2.078219	103	0.01113152	71	0.007829351011971832	1.513185	56	100	0.008058713	
Human Phenotype	Abnormality of the mitochondrion	50	2.704617e-9	3.6095818482000005e-7	2.064023	82	0.008861991	83	0.009683865639759037	1.598434	42	71	0.006044035	
Human Phenotype	Abnormality of mitochondrial metabolism	62	9.325509e-9	0.000001003695508983871	2.035116	79	0.008537772	102	0.020605589410784317	1.566444	40	69	0.005756224	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	121	1.173902e-9	8.883818689256199e-8	2.952226	43	0.004647141	111	0.0018097267834234236	2.210822	18	22	0.002590301	
Mouse Phenotype Single KO	empty decidua capsularis	204	3.111335e-7	0.000013965928723039216	4.211081	19	0.002053388	203	0.027337637091133005	2.286405	11	13	0.001582962	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	212	4.002549e-7	0.00001728836848726415	2.385818	43	0.004647141	163	0.009653174573006136	2.026587	18	24	0.002590301	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	235	9.660857e-7	0.00003764445427617021	2.007263	59	0.00637631	143	0.005296697597692308	2.053608	19	25	0.002734206	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	499	0.0003665347	0.006726168833466934	2.072776	28	0.003026046	218	0.033257778751376144	1.913998	17	24	0.002446395	
Mouse Phenotype	absent segment of posterior cerebral artery	135	1.173902e-9	8.313834831111112e-8	2.952226	43	0.004647141	169	0.0012410788998816567	2.210822	18	22	0.002590301	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	176	1.854766e-8	0.0000010075805526136363	2.677528	43	0.004647141	266	0.008870490921428572	1.891481	21	30	0.003022018	
Mouse Phenotype	enlarged aortic valve	232	2.266858e-7	0.000009341995404310345	3.080909	29	0.003134119	348	0.023791765487068964	2.431904	9	10	0.00129515	
Mouse Phenotype	abnormal cerebral artery morphology	246	4.002549e-7	0.000015556248369512194	2.385818	43	0.004647141	250	0.0065715506568000005	2.026587	18	24	0.002590301	
Mouse Phenotype	abnormal vitelline vein morphology	267	9.660857e-7	0.00003459455197640449	2.007263	59	0.00637631	224	0.0035305576040625002	2.053608	19	25	0.002734206	
Mouse Phenotype	ovary hypoplasia	274	0.000001148332	0.00004007008121167883	3.125982	25	0.002701826	446	0.04545477328923767	2.40188	8	9	0.001151245	
Mouse Phenotype	abnormal tricuspid valve cusp morphology	368	0.00001300647	0.00033792081432065216	3.020427	21	0.002269534	356	0.025485841885112357	2.702115	7	7	0.001007339	
Mouse Phenotype	empty decidua capsularis	570	0.0003995847	0.006702507573157894	2.474097	19	0.002053388	433	0.04143951584064665	2.123091	11	14	0.001582962