# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process adherens junction assembly 120 5.059442e-24 5.548099773166667e-22 3.26702 103 0.01197396 992 0.04722418880342742 1.689916 20 34 0.003059976 GO Biological Process mesoderm formation 134 7.160207e-22 7.031430142761194e-20 2.172834 191 0.02220414 585 0.004402843941880342 1.629382 38 67 0.005813953 GO Biological Process mesoderm morphogenesis 146 1.371981e-20 1.2365683547260275e-18 2.09787 194 0.02255289 496 0.0018312364191733872 1.665425 40 69 0.006119951 GO Biological Process positive regulation of heart growth 266 5.363122e-14 2.653132420977444e-12 2.148193 120 0.01395024 429 0.0006917983834498835 2.0279 24 34 0.003671971 GO Biological Process regulation of cell communication by electrical coupling involved in cardiac conduction 273 9.880675e-14 4.762630121794872e-12 3.485475 51 0.005928854 780 0.022543425202564103 2.553652 8 9 0.00122399 GO Biological Process regulation of epithelial cell proliferation involved in lung morphogenesis 308 5.903316e-13 2.522134261168831e-11 2.906924 62 0.007207626 978 0.04626452791308793 2.513751 7 8 0.001070991 GO Biological Process positive regulation of cardiac muscle cell proliferation 330 1.450441e-12 5.783743369393939e-11 2.270178 94 0.01092769 343 0.0001322683982419825 2.373231 19 23 0.002906977 GO Biological Process positive regulation of cardiac muscle tissue growth 417 6.725516e-11 2.1223276988968824e-9 2.05524 100 0.0116252 521 0.0022808517431477924 2.011001 21 30 0.003212974 GO Biological Process kidney mesenchyme development 420 7.809822e-11 2.446891611857143e-9 2.467166 67 0.007788886 785 0.02262407592484076 2.074842 13 18 0.001988984 GO Biological Process cellular response to catecholamine stimulus 444 1.899547e-10 5.629761029954955e-9 2.228122 79 0.009183911 992 0.04722418880342742 1.689916 20 34 0.003059976 GO Biological Process regulation of actin cytoskeleton reorganization 514 1.513267e-9 3.8741401659533074e-8 2.358895 63 0.007323878 992 0.04722418880342742 1.689916 20 34 0.003059976 GO Biological Process regulation of cell communication by electrical coupling 552 3.037468e-9 7.24094953115942e-8 2.455999 56 0.006510114 715 0.014793969861818182 2.394048 10 12 0.001529988 GO Biological Process paraxial mesoderm development 608 1.07819e-8 2.3335365476973685e-7 2.408634 54 0.00627761 933 0.04016456832797428 2.0279 12 17 0.001835985 GO Biological Process membrane raft organization 621 1.473689e-8 3.122749364090177e-7 2.777223 41 0.004766333 813 0.02354391123124231 1.958767 15 22 0.002294982 GO Biological Process p38MAPK cascade 634 1.852851e-8 3.845688692271293e-7 4.060173 24 0.002790049 841 0.027790212021403093 2.872858 6 6 0.0009179927 GO Biological Process diaphragm development 694 4.876316e-8 9.246029141786744e-7 3.036087 33 0.003836317 978 0.04626452791308793 2.513751 7 8 0.001070991 GO Biological Process blastoderm segmentation 727 8.346737e-8 0.0000015107938402063274 2.184992 58 0.006742618 785 0.02262407592484076 2.074842 13 18 0.001988984 GO Biological Process response to laminar fluid shear stress 742 1.061584e-7 0.0000018826662878706198 2.509967 43 0.004998837 743 0.018512215800807533 2.257246 11 14 0.001682987 GO Biological Process regulation of Rac protein signal transduction 892 7.673109e-7 0.000011319556203026905 2.549356 36 0.004185073 552 0.003148450469746377 2.46245 12 14 0.001835985 GO Biological Process intestinal epithelial cell differentiation 1058 0.000004434381 0.00005515313759829867 2.292358 38 0.004417577 785 0.02262407592484076 2.074842 13 18 0.001988984 GO Cellular Component MOZ/MORF histone acetyltransferase complex 106 6.723038e-7 0.000010959820437735849 3.318581 24 0.002790049 69 0.01547338852173913 2.872858 7 7 0.001070991 GO Cellular Component junctional sarcoplasmic reticulum membrane 125 0.000003945269 0.00005453939865600001 2.607242 30 0.003487561 81 0.028506922666666663 2.553652 8 9 0.00122399 Mouse Phenotype Single KO absent corpus callosum 132 4.93982e-18 3.4268130106060607e-16 2.407057 125 0.0145315 438 0.007691365702739726 1.885313 21 32 0.003212974 Mouse Phenotype Single KO dilated brain ventricles 163 1.626467e-16 9.137152342944786e-15 2.106718 151 0.01755406 751 0.0375935696804261 1.47747 36 70 0.005507956 Mouse Phenotype Single KO abnormal cell adhesion 195 6.81756e-15 3.201456252307692e-13 2.199563 122 0.01418275 628 0.024792402525477708 1.55816 32 59 0.004895961 Mouse Phenotype Single KO abnormal sternebra morphology 215 4.061852e-14 1.7299711053023259e-12 2.046033 136 0.01581028 561 0.0183806453315508 1.641633 28 49 0.004283966 Mouse Phenotype Single KO abnormal fourth pharyngeal arch morphology 252 6.005511e-13 2.1822406439285714e-11 2.488121 81 0.009416415 733 0.03626766642837653 1.915239 14 21 0.002141983 Mouse Phenotype Single KO abnormal radial glial cell morphology 265 1.091309e-12 3.770987363396226e-11 2.543065 76 0.008835155 301 0.0013938894918936878 2.298286 16 20 0.00244798 Mouse Phenotype Single KO impaired lung alveolus development 273 1.806936e-12 6.060847235164835e-11 2.076201 114 0.01325273 742 0.03696464933018868 1.663234 22 38 0.003365973 Mouse Phenotype Single KO arrest of tooth development 276 2.419163e-12 8.026186808333334e-11 3.331439 48 0.005580098 632 0.025733633117088605 2.872858 6 6 0.0009179927 Mouse Phenotype Single KO abnormal metacarpal bone morphology 280 2.918301e-12 9.543886520357143e-11 2.123644 106 0.01232272 221 0.00019241392784615383 2.112396 25 34 0.003824969 Mouse Phenotype Single KO abnormal fetal cardiomyocyte morphology 313 1.780147e-11 5.20792526485623e-10 2.497708 70 0.008137642 713 0.035178188757363255 1.838629 16 25 0.00244798 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 326 2.348313e-11 6.596166300920245e-10 2.445166 72 0.008370146 386 0.00437167278626943 1.863475 24 37 0.003671971 Mouse Phenotype Single KO abnormal aortic valve cusp morphology 338 2.843341e-11 7.703098679585798e-10 2.434385 72 0.008370146 697 0.032483045193687235 1.783153 18 29 0.002753978 Mouse Phenotype Single KO interrupted aortic arch 339 2.889049e-11 7.803841207374632e-10 2.046696 105 0.01220646 742 0.03696464933018868 1.663234 22 38 0.003365973 Mouse Phenotype Single KO abnormal metanephros morphology 387 1.137431e-10 2.691332213695091e-9 2.390164 70 0.008137642 417 0.006319401610551558 2.154644 15 20 0.002294982 Mouse Phenotype Single KO abnormal facial nerve morphology 392 1.516714e-10 3.542997473979592e-9 2.266361 77 0.008951407 208 0.0001195769046201923 2.257246 22 28 0.003365973 Mouse Phenotype Single KO cervical vertebral transformation 408 3.041696e-10 6.826669184313726e-9 2.526409 60 0.006975122 555 0.017402507270270273 1.738835 23 38 0.003518972 Mouse Phenotype Single KO athymia 412 3.602244e-10 8.006249589320388e-9 3.419285 37 0.004301325 525 0.014020444909714285 2.394048 10 12 0.001529988 Mouse Phenotype Single KO abnormal cervical atlas morphology 414 3.746205e-10 8.285990141304348e-9 2.037453 94 0.01092769 775 0.040750138750967745 1.596032 25 45 0.003824969 Mouse Phenotype Single KO abnormal nasal capsule morphology 421 4.437637e-10 9.65212399263658e-9 2.149985 82 0.009532667 735 0.03628759631156462 1.96564 13 19 0.001988984 Mouse Phenotype Single KO abnormal basement membrane morphology 426 5.420785e-10 1.1652142780516432e-8 2.188153 78 0.009067659 657 0.028149677257229833 1.723715 21 35 0.003212974 Mouse Phenotype perimembraneous ventricular septal defect 91 3.107213e-25 3.264622361868132e-23 2.049277 255 0.02964427 230 0.00002133903377869565 1.736343 55 91 0.008414933 Mouse Phenotype abnormal interventricular septum membranous part morphology 95 9.280266e-25 9.339855076421053e-23 2.019713 259 0.03010928 242 0.00003123111317231405 1.71149 56 94 0.008567931 Mouse Phenotype abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology 134 2.155637e-20 1.5380630863432836e-18 2.373183 147 0.01708905 983 0.03722286963784334 1.509468 31 59 0.004742962 Mouse Phenotype abnormal sternebra morphology 142 9.303853e-20 6.264375953028169e-18 2.162495 173 0.0201116 705 0.011717846325531914 1.571094 35 64 0.005354957 Mouse Phenotype abnormal cell adhesion 163 2.025814e-18 1.188270408220859e-16 2.182546 157 0.01825157 623 0.007265334839807383 1.549831 41 76 0.00627295 Mouse Phenotype impaired branching involved in ureteric bud morphogenesis 198 6.395158e-17 3.088086143333333e-15 2.014025 173 0.0201116 313 0.00019679873658785943 1.846837 36 56 0.005507956 Mouse Phenotype interrupted aortic arch 207 2.531159e-16 1.1691019902898552e-14 2.107078 149 0.01732155 543 0.004466529437569061 1.735685 29 48 0.004436965 Mouse Phenotype abnormal paraxial mesoderm morphology 217 5.478707e-16 2.4139132547004612e-14 2.389902 111 0.01290398 1003 0.039304184306081756 1.551343 27 50 0.004130967 Mouse Phenotype abnormal aortic valve cusp morphology 225 8.815233e-16 3.7458863427999995e-14 2.638125 91 0.01057894 732 0.013776656495901641 1.738835 23 38 0.003518972 Mouse Phenotype absent corpus callosum 228 1.004521e-15 4.212379509210526e-14 2.011712 160 0.01860033 445 0.0017692512330337077 1.795536 30 48 0.004589963 Mouse Phenotype abnormal thyroid cartilage morphology 246 2.844121e-15 1.1053919057317073e-13 2.538748 94 0.01092769 1052 0.04393535792965779 1.767913 16 26 0.00244798 Mouse Phenotype abnormal tectum morphology 250 4.584003e-15 1.7531061073199998e-13 2.102462 137 0.01592653 708 0.012331221425423727 1.710035 25 42 0.003824969 Mouse Phenotype abnormal Mullerian duct morphology 293 6.648276e-14 2.1694254892832768e-12 2.235482 109 0.01267147 556 0.004944971554856115 1.76289 27 44 0.004130967 Mouse Phenotype impaired lung alveolus development 307 2.10151e-13 6.5448003615635176e-12 2.004509 135 0.01569402 969 0.03402962170897832 1.596032 25 45 0.003824969 Mouse Phenotype abnormal fourth pharyngeal arch artery morphology 310 2.526028e-13 7.790759260645162e-12 2.308897 97 0.01127645 907 0.027549615658213893 1.808837 17 27 0.002600979 Mouse Phenotype increased B cell apoptosis 314 3.212384e-13 9.78140236433121e-12 2.143923 113 0.01313648 1031 0.04246001151212415 1.556131 26 48 0.003977968 Mouse Phenotype brachydactyly 318 3.917646e-13 1.1778809247169812e-11 2.17998 108 0.01255522 587 0.005683341809540035 1.835437 23 36 0.003518972 Mouse Phenotype abnormal fourth pharyngeal arch morphology 331 9.335344e-13 2.696532446646526e-11 2.193906 103 0.01197396 874 0.025415249296338673 1.760784 19 31 0.002906977 Mouse Phenotype short nasal bone 343 1.583252e-12 4.413257251311953e-11 2.058509 117 0.01360149 506 0.003387437736166008 1.841576 25 39 0.003824969 Mouse Phenotype abnormal nephrogenic zone morphology 347 1.974107e-12 5.4393190279538895e-11 2.34251 87 0.01011393 516 0.003533743747093023 2.334197 13 16 0.001988984