# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process myeloid cell differentiation 75 5.071885e-13 8.898791295333334e-11 2.146617 109 0.03872114 147 0.0021789477853061223 1.711614 55 191 0.01741057 GO Biological Process regulation of lymphocyte differentiation 101 2.431525e-11 3.1679641064356438e-9 2.082078 100 0.03552398 225 0.009114695394666666 1.709377 44 153 0.01392846 GO Biological Process regulation of T cell differentiation 108 7.497363e-11 9.134981455277778e-9 2.142437 89 0.03161634 179 0.004744706078435754 1.8398 39 126 0.01234568 GO Biological Process platelet aggregation 116 1.444965e-10 1.639163313362069e-8 3.867697 33 0.01172291 164 0.0035079639317682925 2.609548 18 41 0.005698006 GO Biological Process positive regulation of leukocyte differentiation 133 5.246117e-10 5.190500270902256e-8 2.02078 93 0.0330373 135 0.0016077237314074072 1.891263 42 132 0.01329535 GO Biological Process regulation of megakaryocyte differentiation 146 1.537134e-9 1.3854209798630137e-7 2.91489 43 0.01527531 286 0.02105606557972028 1.955253 25 76 0.007913897 GO Biological Process positive regulation of T cell differentiation 168 5.190018e-9 4.0652051703571423e-7 2.325843 60 0.02131439 193 0.005578733504715026 2.11703 26 73 0.008230453 GO Biological Process myeloid leukocyte differentiation 204 3.396301e-8 0.0000021907806303431374 2.170249 62 0.02202487 314 0.02859887377643312 1.814475 29 95 0.00918012 GO Biological Process positive regulation of lymphocyte differentiation 216 7.047951e-8 0.000004293703111527778 2.124504 62 0.02202487 233 0.009409656393991416 1.981323 28 84 0.008863564 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 220 8.086518e-8 0.000004836840471 3.087132 31 0.01101243 340 0.032944307337058824 2.091397 19 54 0.006014562 GO Biological Process platelet formation 222 9.001474e-8 0.00000533560343990991 4.567624 19 0.006749556 274 0.018135536895255475 3.128405 10 19 0.003165559 GO Biological Process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding 237 1.692494e-7 0.000009397269428691985 11.32336 9 0.003197158 317 0.02879250636340694 4.953308 5 6 0.001582779 GO Biological Process homotypic cell-cell adhesion 238 1.711664e-7 0.000009463775872268909 2.630438 38 0.01349911 181 0.0048199177788950266 2.355158 21 53 0.006647673 GO Biological Process platelet morphogenesis 258 3.228854e-7 0.00001646840689379845 4.193514 19 0.006749556 308 0.027416409073376623 2.971985 10 20 0.003165559 GO Biological Process positive regulation of alpha-beta T cell differentiation 264 4.806298e-7 0.000023956846735606058 2.519399 38 0.01349911 189 0.005519850985820106 2.590961 17 39 0.00538145 GO Biological Process regulation of membrane permeability 267 5.043408e-7 0.000024856256880898877 2.385528 42 0.01492007 379 0.04523029534564644 1.834559 25 81 0.007913897 GO Biological Process regulation of alpha-beta T cell activation 277 7.027276e-7 0.000033383366384115526 2.130737 52 0.01847247 235 0.009795055638297873 2.033463 26 76 0.008230453 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 293 9.52581e-7 0.00004278161562798634 2.692124 32 0.01136767 220 0.008281562817727272 2.773852 14 30 0.004431782 GO Biological Process embryonic hemopoiesis 310 0.000001564334 0.00006640345518064516 2.913189 27 0.009591474 308 0.027416409073376623 2.971985 10 20 0.003165559 GO Biological Process positive regulation of alpha-beta T cell activation 378 0.000005579332 0.00019422865023280424 2.209597 40 0.01420959 264 0.013845889831060604 2.258708 19 50 0.006014562 GO Cellular Component histone locus body 234 0.006377745 0.047097193846153844 3.704334 6 0.002131439 33 0.04188293410909091 5.94397 4 4 0.001266223 Mouse Phenotype Single KO abnormal T cell physiology 12 2.401523e-28 1.8325621759166666e-25 2.086808 265 0.09413854 64 0.00004977464766875 1.505806 133 525 0.04210193 Mouse Phenotype Single KO abnormal cytokine secretion 22 8.453119e-25 3.5184186674090906e-22 2.008117 253 0.08987567 81 0.00014241644696296298 1.457366 140 571 0.04431782 Mouse Phenotype Single KO abnormal T cell activation 28 2.074495e-23 6.784339541071428e-21 2.363013 168 0.05968028 101 0.0003882791938514851 1.624822 79 289 0.02500791 Mouse Phenotype Single KO abnormal erythropoiesis 34 1.14175e-21 3.075001397058824e-19 3.001901 103 0.0365897 20 6.2468184085e-8 2.539696 47 110 0.01487813 Mouse Phenotype Single KO abnormal neutrophil cell number 36 1.809383e-21 4.602366703055556e-19 2.451741 143 0.05079929 178 0.006653471055617977 1.53035 69 268 0.02184236 Mouse Phenotype Single KO abnormal granulocyte number 38 6.59181e-21 1.5884527413157895e-18 2.013091 211 0.0749556 83 0.00015597570433734939 1.526891 112 436 0.03545426 Mouse Phenotype Single KO abnormal T cell proliferation 40 1.724838e-19 3.9485853915e-17 2.277795 149 0.05293073 134 0.001980428808283582 1.594168 70 261 0.02215891 Mouse Phenotype Single KO decreased myeloid cell number 41 4.479997e-19 1.0005690860731706e-16 2.067132 180 0.06394316 73 0.00009986783506712329 1.656516 85 305 0.02690725 Mouse Phenotype Single KO decreased T cell proliferation 42 8.85735e-19 1.9311131892857144e-16 2.66247 107 0.03801066 168 0.005152005090238095 1.743564 44 150 0.01392846 Mouse Phenotype Single KO abnormal neutrophil morphology 43 9.125145e-19 1.943231459651163e-16 2.263303 145 0.05150977 196 0.008016093863265307 1.507221 71 280 0.02247547 Mouse Phenotype Single KO decreased erythroid progenitor cell number 44 1.280393e-18 2.6646724320454545e-16 3.604828 68 0.02415631 112 0.0007348493317589286 2.564065 22 51 0.006964229 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 46 2.21011e-18 4.3995602760869564e-16 3.565477 68 0.02415631 79 0.00014229189802531647 2.691609 24 53 0.007597341 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 48 1.231446e-17 2.3492397962499997e-15 5.195377 43 0.01527531 164 0.00487536994 2.869503 14 29 0.004431782 Mouse Phenotype Single KO abnormal platelet morphology 57 2.431055e-16 3.9054685324561406e-14 2.119627 144 0.05115453 68 0.00006956984965 1.720623 77 266 0.0243748 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 65 1.08063e-15 1.5223582938461536e-13 4.563689 43 0.01527531 325 0.02700442971846154 2.377588 14 35 0.004431782 Mouse Phenotype Single KO abnormal platelet activation 66 1.225971e-15 1.700941885909091e-13 3.229708 65 0.02309059 95 0.00032583796491578946 2.23773 32 85 0.01012979 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 67 1.660287e-15 2.2691415013432833e-13 2.460732 100 0.03552398 94 0.0003067417704893617 1.834139 54 175 0.01709402 Mouse Phenotype Single KO abnormal platelet physiology 68 1.927643e-15 2.595798081029412e-13 2.810478 79 0.02806394 58 0.000032701194217241374 2.21548 41 110 0.01297879 Mouse Phenotype Single KO abnormal platelet aggregation 69 2.362675e-15 3.1355094166666667e-13 3.254977 63 0.02238011 100 0.00037299107373000006 2.286142 30 78 0.009496676 Mouse Phenotype Single KO abnormal incidence of induced tumors 71 6.925314e-15 8.931704267323943e-13 2.173443 123 0.04369449 75 0.00010317390912133332 1.809034 63 207 0.01994302 Mouse Phenotype abnormal erythropoiesis 34 1.172977e-23 3.2984803226470587e-21 2.856656 122 0.04333925 20 4.04548999815e-9 2.393545 60 149 0.01899335 Mouse Phenotype abnormal T cell activation 38 8.518201e-23 2.143224204236842e-20 2.079031 214 0.07602131 108 0.00004672666084444445 1.569557 108 409 0.03418803 Mouse Phenotype decreased erythroid progenitor cell number 47 5.896943e-19 1.1995887664468085e-16 3.208078 81 0.02877442 189 0.0010970721392063493 2.189884 28 76 0.008863564 Mouse Phenotype abnormal T cell proliferation 51 3.258361e-18 6.108468533529412e-16 2.015538 182 0.06465364 214 0.0016472584351401869 1.485992 92 368 0.02912314 Mouse Phenotype extramedullary hematopoiesis 55 6.519721e-18 1.1333645905636363e-15 2.545336 110 0.03907638 80 0.000004404771822 2.003967 59 175 0.0186768 Mouse Phenotype abnormal neutrophil cell number 57 8.761921e-18 1.4696969593157895e-15 2.05197 170 0.06039076 261 0.003714430183908046 1.464944 87 353 0.02754036 Mouse Phenotype abnormal embryonic hematopoiesis 59 4.684509e-17 7.591286533728814e-15 3.246537 71 0.02522202 128 0.00013864167075 2.533495 26 61 0.008230453 Mouse Phenotype abnormal embryonic erythropoiesis 60 4.916241e-17 7.834030033499999e-15 4.769243 45 0.01598579 220 0.002053697584909091 2.876114 15 31 0.004748338 Mouse Phenotype decreased T cell proliferation 62 5.807386e-17 8.955551217096772e-15 2.231336 134 0.04760213 143 0.0003508221741608391 1.73017 62 213 0.01962646 Mouse Phenotype abnormal erythroid progenitor cell morphology 63 5.886641e-17 8.933678508095238e-15 2.612038 99 0.03516874 100 0.000027800041650000002 2.147821 43 119 0.0136119 Mouse Phenotype altered susceptibility to autoimmune disorder 72 1.538121e-15 2.04249651125e-13 2.04625 148 0.05257549 248 0.0030300189176612905 1.485992 84 336 0.02659069 Mouse Phenotype abnormal embryonic erythrocyte morphology 74 2.172985e-15 2.8075553493243244e-13 4.201101 46 0.01634103 341 0.008425335447800587 2.438552 16 39 0.005064894 Mouse Phenotype abnormal platelet physiology 77 3.440167e-15 4.271615154155845e-13 2.660271 85 0.03019538 103 0.00003576023785048544 2.071383 46 132 0.01456157 Mouse Phenotype abnormal platelet aggregation 80 4.634402e-15 5.53868969025e-13 3.10351 66 0.02344583 168 0.000774170674107143 2.086713 33 94 0.01044634 Mouse Phenotype abnormal mean corpuscular hemoglobin 82 7.916705e-15 9.230684939634146e-13 2.350398 104 0.03694494 125 0.000113193979296 1.841338 57 184 0.01804368 Mouse Phenotype abnormal platelet activation 84 1.086623e-14 1.2368098217857144e-12 3.045712 66 0.02344583 228 0.0023959014735526313 1.96151 33 100 0.01044634 Mouse Phenotype decreased erythrocyte cell number 86 1.241032e-14 1.3797101106976745e-12 2.069066 135 0.04795737 217 0.001819680802534562 1.621083 63 231 0.01994302 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 100 1.715769e-13 1.6404467409e-11 2.233492 104 0.03694494 139 0.0002459500529352518 1.816213 55 180 0.01741057 Mouse Phenotype increased neutrophil cell number 109 1.455241e-12 1.2764733211926606e-10 2.039293 118 0.04191829 464 0.025966439663793105 1.479388 56 225 0.01772713 Mouse Phenotype abnormal iron homeostasis 111 1.954495e-12 1.6835069094594598e-10 2.553675 73 0.0259325 297 0.005380657168686869 1.740734 41 140 0.01297879