# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	128	4.289929e-72	4.410248102421875e-70	2.254442	621	0.01556742	546	0.0008818438778021978	1.202579	102	113	0.007237122	
GO Biological Process	regulation of DNA-templated transcription in response to stress	142	9.57096e-69	8.869314270422535e-67	2.137441	666	0.0166955	479	0.00031617588079331944	1.209118	108	119	0.007662835	
GO Biological Process	endoplasmic reticulum unfolded protein response	172	1.422383e-61	1.0882056916860465e-59	2.178166	570	0.01428894	1087	0.03900234385372585	1.145284	98	114	0.006953313	
GO Biological Process	response to epidermal growth factor	200	7.5311e-56	4.955087244999999e-54	2.345687	440	0.01103006	1075	0.03773214108186047	1.237107	39	42	0.002767135	
GO Biological Process	liver regeneration	229	5.707097e-53	3.2794624202183404e-51	2.736347	313	0.007846381	558	0.0010169312931899643	1.332269	35	35	0.002483326	
GO Biological Process	cellular response to unfolded protein	231	1.073183e-52	6.11342644891775e-51	2.007956	590	0.0147903	1018	0.03185818460019646	1.145091	104	121	0.007379027	
GO Biological Process	regulation of mitochondrial membrane permeability	300	2.527725e-43	1.1087444425e-41	2.060042	452	0.01133088	676	0.004679313147633136	1.222767	67	73	0.004753796	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	324	2.14641e-40	8.717471972222223e-39	2.102606	400	0.01002732	860	0.014697957290930232	1.195626	70	78	0.004966652	
GO Biological Process	apoptotic mitochondrial changes	347	1.014811e-38	3.848385576080692e-37	2.064334	400	0.01002732	467	0.00025720330618201286	1.287107	57	59	0.004044274	
GO Biological Process	mitochondrial transmembrane transport	371	3.749258e-37	1.329824421078167e-35	2.066689	382	0.009576095	1062	0.035822292197740115	1.171755	73	83	0.005179509	
GO Biological Process	regulation of plasma lipoprotein particle levels	375	4.258307e-37	1.4942683150133334e-35	2.031358	398	0.009977188	834	0.012871087706834533	1.204517	66	73	0.004682844	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	389	2.670226e-36	9.032777360925449e-35	2.061744	375	0.009400617	855	0.014140756821988303	1.291897	32	33	0.00227047	
GO Biological Process	cotranslational protein targeting to membrane	430	3.11642e-33	9.536969948837208e-32	2.012463	363	0.009099797	788	0.00952106920571066	1.182729	87	98	0.00617284	
GO Biological Process	negative regulation of Notch signaling pathway	431	3.416014e-33	1.0429542511832946e-31	2.322917	261	0.006542829	855	0.014140756821988303	1.291897	32	33	0.00227047	
GO Biological Process	regulation of mRNA catabolic process	432	3.669067e-33	1.1176215891898147e-31	2.206871	291	0.007294879	930	0.021814579865591398	1.289293	30	31	0.002128565	
GO Biological Process	bile acid metabolic process	696	5.515855e-23	1.0428611486350575e-21	2.009016	246	0.006166805	987	0.02821257602431611	1.260255	35	37	0.002483326	
GO Biological Process	bile acid biosynthetic process	860	1.123859e-19	1.7196349512790697e-18	2.178478	171	0.004286681	1156	0.04887131937889273	1.282926	26	27	0.001844757	
GO Biological Process	lipid storage	889	3.72548e-19	5.514464715410574e-18	2.139801	173	0.004336818	1100	0.039818583714545455	1.284688	27	28	0.001915709	
GO Biological Process	mitochondrial calcium ion transport	1223	8.231128e-15	8.85637067473426e-14	2.269508	114	0.002857787	871	0.01537711488174512	1.332269	24	24	0.001702852	
GO Cellular Component	very-low-density lipoprotein particle	176	2.167507e-13	2.128097781818182e-12	2.276701	101	0.002531899	146	0.03800937205479452	1.332269	20	20	0.001419044	
GO Molecular Function	rRNA binding	145	4.513616e-17	1.3142404656551724e-15	2.074377	164	0.004111203	123	0.0334379688308943	1.221247	55	60	0.00390237	
Mouse Phenotype Single KO	extramedullary hematopoiesis	68	6.521778e-70	8.782341344999998e-68	2.078052	724	0.01814946	696	0.042387845096264365	1.145284	98	114	0.006953313	
Mouse Phenotype Single KO	abnormal fibroblast migration	147	4.361581e-46	2.7169385861904765e-44	2.072388	475	0.01190745	368	0.0028022759016304347	1.299775	40	41	0.002838087	
Mouse Phenotype Single KO	decreased fibroblast cell migration	151	1.172234e-45	7.108706449006623e-44	2.121254	445	0.0111554	476	0.01050022224684874	1.294204	34	35	0.002412374	
Mouse Phenotype Single KO	decreased cell migration	154	2.391113e-45	1.4217806325324674e-43	2.022619	496	0.01243388	394	0.0043458726901015226	1.275577	45	47	0.003192848	
Mouse Phenotype Single KO	increased liver adenoma incidence	595	6.625612e-19	1.0196761190588234e-17	2.393841	134	0.003359154	692	0.04249589028901734	1.332269	20	20	0.001419044	
Mouse Phenotype	pancytopenia	479	3.314125e-27	6.615104201461378e-26	2.250195	226	0.005665438	869	0.028362612980437282	1.286329	28	29	0.001986661	
Mouse Phenotype	increased liver adenoma incidence	492	8.254433e-27	1.6040779250609755e-25	2.514201	178	0.004462159	922	0.03451659955965293	1.284688	27	28	0.001915709	
Mouse Phenotype	decreased liver cholesterol level	542	4.730641e-25	8.344955461439114e-24	2.12236	236	0.005916121	761	0.014959296390275953	1.290636	31	32	0.002199518	
Mouse Phenotype	abnormal Langerhans cell morphology	859	2.992325e-17	3.330572680442375e-16	2.016421	178	0.004462159	965	0.04240469950569948	1.332269	19	19	0.001348091