# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 63 6.394572e-22 1.335653538857143e-19 2.578077 136 0.01402206 789 0.04195936446134347 1.333588 62 118 0.008380643 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 148 1.152157e-12 1.0244077002027027e-10 2.002673 127 0.01309413 692 0.02382372295953757 1.404066 52 94 0.007028927 GO Biological Process placenta blood vessel development 152 1.941242e-12 1.6805791761842103e-10 2.512646 76 0.007835859 697 0.024686642710186512 1.719371 21 31 0.002838605 GO Biological Process positive regulation of protein export from nucleus 175 2.218197e-11 1.6679573898857143e-9 3.372418 43 0.004433447 797 0.042623140235884566 1.870193 14 19 0.001892403 GO Biological Process mitochondrial transmembrane transport 222 9.576614e-10 5.6765163795495494e-8 2.024889 91 0.009382411 680 0.02096700875882353 1.437248 47 83 0.006353068 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 242 2.660806e-9 1.4468407501652893e-7 2.108636 78 0.008042066 569 0.0073926452571177505 1.837948 21 29 0.002838605 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 252 3.759163e-9 1.962969282420635e-7 2.795307 44 0.00453655 596 0.009502215462751679 1.903589 18 24 0.00243309 GO Biological Process negative regulation of peptidyl-threonine phosphorylation 453 8.49325e-7 0.00002467167257174393 2.1417 51 0.005258274 366 0.0007355658087978142 2.368911 14 15 0.001892403 GO Biological Process beta-catenin destruction complex disassembly 690 0.00002632234 0.0005019937276231883 2.044642 41 0.00422724 430 0.0018020151876511627 2.076642 18 22 0.00243309 GO Biological Process positive regulation of pri-miRNA transcription from RNA polymerase II promoter 719 0.00003400066 0.0006222735534631432 2.062134 39 0.004021033 701 0.025061700320970045 1.903589 15 20 0.002027575 GO Biological Process AMP metabolic process 770 0.0000526509 0.0008997833676623377 2.263038 30 0.003093102 554 0.006440494404693141 2.326609 11 12 0.001486888 GO Biological Process AMP biosynthetic process 775 0.00005831774 0.000990197600851613 2.716578 21 0.002165172 710 0.027266782433802816 2.538118 7 7 0.0009462017 GO Biological Process DNA recombinase assembly 1318 0.002038432 0.020351841189681336 2.256793 17 0.001752758 716 0.02706642731424581 2.284307 9 10 0.001216545 GO Cellular Component clathrin adaptor complex 133 0.000008767098 0.00011390635596992482 2.046197 46 0.004742757 120 0.032975884799999994 1.692079 20 30 0.002703433 GO Cellular Component Sin3 complex 149 0.00002061946 0.00023913038174496642 2.52106 27 0.002783792 100 0.0195088608 2.147639 11 13 0.001486888 GO Molecular Function DNA polymerase binding 26 3.920217e-13 6.365829297692308e-11 5.596045 29 0.002989999 127 0.026186133870866143 2.062221 13 16 0.001757232 GO Molecular Function frizzled binding 54 5.412693e-9 4.231924045555555e-7 2.021395 83 0.008557583 114 0.00931523192105263 1.762582 25 36 0.003379292 GO Molecular Function MAP kinase activity 175 0.00006608932 0.0015944520516571429 2.394662 26 0.002680689 98 0.002096270820612245 2.356824 13 14 0.001757232 GO Molecular Function cAMP response element binding 192 0.0001215681 0.0026732318656250004 2.261631 27 0.002783792 134 0.035571452761194035 2.147639 11 13 0.001486888 GO Molecular Function procollagen-proline dioxygenase activity 245 0.0005373939 0.009260722635918367 3.020053 13 0.001340344 140 0.04436694731428571 2.538118 7 7 0.0009462017 Human Phenotype Abnormality of adipose tissue 10 3.113103e-14 2.0773736319e-11 2.360274 100 0.01031034 57 0.00100194556477193 1.736607 39 57 0.005271695 Mouse Phenotype Single KO abnormal sternebra number 2 2.571096e-19 1.1771763035999999e-15 6.531117 39 0.004021033 403 0.02565289241935484 2.147639 11 13 0.001486888 Mouse Phenotype Single KO vertebral transformation 9 7.154137e-14 7.278936945444445e-11 2.001721 141 0.01453758 99 0.00004344613570909091 1.655295 60 92 0.0081103 Mouse Phenotype Single KO abnormal cellular replicative senescence 43 6.185072e-10 1.317132658232558e-7 2.169773 79 0.00814517 393 0.022847572449363866 1.522871 36 60 0.00486618 Mouse Phenotype Single KO thoracic vertebral transformation 49 3.800547e-9 7.102369158979592e-7 2.205507 69 0.007114135 319 0.01037455950031348 1.639201 31 48 0.004190322 Mouse Phenotype Single KO thin interventricular septum 51 5.935348e-9 0.0000010656859144313727 2.714752 45 0.004639654 341 0.01412117619090909 2.003778 15 19 0.002027575 Mouse Phenotype Single KO decreased mortality induced by ionizing radiation 70 3.51076e-8 0.000004592575617142857 4.626633 20 0.002062068 428 0.03147594659813084 2.538118 7 7 0.0009462017 Mouse Phenotype Single KO increased fibroblast apoptosis 147 0.000003462623 0.00021569550211564628 2.019123 52 0.005361377 423 0.03157632339007092 1.667906 23 35 0.003108948 Mouse Phenotype Single KO abnormal DNA replication 307 0.00009434275 0.0028139953151465795 2.156046 31 0.003196206 282 0.005540196065602836 1.986354 18 23 0.00243309 Mouse Phenotype abnormal sternebra number 4 2.571096e-19 6.145562214e-16 6.531117 39 0.004021033 715 0.015096819000000003 2.147639 11 13 0.001486888 Mouse Phenotype sacral vertebral transformation 11 1.785286e-15 1.5517381314545458e-12 4.969044 39 0.004021033 473 0.0024945417114164907 2.054667 17 21 0.002297918 Mouse Phenotype thoracic vertebral transformation 15 1.869869e-14 1.1918545006000001e-11 2.485439 92 0.009485514 384 0.00069727825234375 1.692079 38 57 0.005136523 Mouse Phenotype abnormal rib development 16 2.899943e-14 1.7328971889375e-11 2.72261 77 0.007938963 378 0.0006010097716666668 1.922817 25 33 0.003379292 Mouse Phenotype abnormal cellular replicative senescence 18 5.720127e-14 3.0383407915e-11 2.15485 119 0.01226931 429 0.001371114483006993 1.541 51 84 0.006893755 Mouse Phenotype early cellular replicative senescence 25 8.704628e-13 3.32899793232e-10 2.169398 106 0.01092896 458 0.0020472990175545848 1.564594 45 73 0.006082725 Mouse Phenotype delayed chorioallantoic fusion 31 2.682668e-12 8.273867338064516e-10 9.470333 18 0.001855861 947 0.03771796327032735 2.538118 6 6 0.00081103 Mouse Phenotype enlarged liver sinusoidal spaces 33 3.781815e-12 1.095694945909091e-9 2.276129 90 0.009279307 986 0.040706132041582146 1.547633 25 41 0.003379292 Mouse Phenotype decreased mesenchymal cell proliferation involved in lung development 67 2.927486e-9 4.177566215820896e-7 2.710091 47 0.00484586 749 0.018799338588785047 2.284307 9 10 0.001216545 Mouse Phenotype increased kidney tumor incidence 86 2.241399e-8 0.0000024918623068604653 3.209962 32 0.003299309 990 0.040673015509090915 1.903589 12 16 0.00162206 Mouse Phenotype increased salivary adenocarcinoma incidence 100 5.79632e-8 0.000005541861552 7.275077 13 0.001340344 947 0.03771796327032735 2.538118 6 6 0.00081103 Mouse Phenotype abnormal carbon dioxide level 171 0.00000103541 0.00005789213456140351 2.793339 30 0.003093102 923 0.035105495574214524 2.256105 8 9 0.001081373 Mouse Phenotype increased cellular sensitivity to DNA damaging agents 176 0.000001192679 0.00006479093135795454 2.260514 44 0.00453655 769 0.01967156478803641 1.845904 16 22 0.002162747 Mouse Phenotype decreased spongiotrophoblast size 186 0.000001864301 0.00009583108527419355 2.525585 34 0.003505516 873 0.028272873621993128 1.870193 14 19 0.001892403 Mouse Phenotype absent patella 287 0.00002165311 0.0007213428038675958 2.566281 26 0.002680689 613 0.009035480336867862 2.538118 8 8 0.001081373 Mouse Phenotype increased adrenal gland tumor incidence 292 0.00002349804 0.000769399864520548 2.553538 26 0.002680689 824 0.02477986098786408 1.940914 13 17 0.001757232 Mouse Phenotype decreased renal tubule number 341 0.00004903133 0.001374746469589443 2.834404 20 0.002062068 613 0.009035480336867862 2.538118 8 8 0.001081373 Mouse Phenotype absent metanephros 393 0.00009924687 0.002414502096870229 2.181318 30 0.003093102 853 0.027461198352872213 2.115099 10 12 0.001351717 Mouse Phenotype abnormal left subclavian artery morphology 420 0.0001461306 0.0033265587300000004 2.000089 35 0.003608619 990 0.040673015509090915 1.903589 12 16 0.00162206 Mouse Phenotype tumor regression 421 0.000147137 0.0033415127244655583 3.695421 12 0.001237241 613 0.009035480336867862 2.538118 8 8 0.001081373