# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process lymphocyte activation 43 2.056836e-136 6.294396493953488e-134 2.020879 1485 0.0702759 130 1.2574203917692308e-11 1.35917 252 348 0.02518992 GO Biological Process leukocyte cell-cell adhesion 100 3.796322e-100 4.9955801198e-98 2.015815 1104 0.05224552 225 1.5581051388444445e-8 1.355172 187 259 0.01869252 GO Biological Process lymphocyte differentiation 101 4.022915e-100 5.241340444059406e-98 2.052198 1057 0.0500213 178 5.689813356573034e-10 1.416244 166 220 0.01659336 GO Biological Process leukocyte aggregation 102 3.049622e-98 3.934311362549019e-96 2.066818 1020 0.04827031 213 9.698479540845071e-9 1.383015 168 228 0.01679328 GO Biological Process lymphocyte aggregation 114 3.396566e-90 3.920650174912281e-88 2.030328 978 0.04628271 217 1.1216246475576037e-8 1.386575 164 222 0.01639344 GO Biological Process T cell activation 118 9.152553e-89 1.020664787516949e-86 2.023101 971 0.04595145 231 2.0570781115584414e-8 1.382117 162 220 0.01619352 GO Biological Process positive regulation of leukocyte cell-cell adhesion 120 3.29585e-88 3.614174179166667e-86 2.036985 949 0.04491032 78 7.52656166525641e-14 1.501559 168 210 0.01679328 GO Biological Process adaptive immune response 127 9.590451e-86 9.937066512519686e-84 2.075634 882 0.04173962 411 0.00005091486043065693 1.265359 180 267 0.0179928 GO Biological Process regulation of adaptive immune response 154 4.141122e-73 3.5385080777922077e-71 2.363175 567 0.02683262 458 0.00013508905854803493 1.361146 95 131 0.009496202 GO Biological Process regulation of B cell activation 174 1.141956e-68 8.636206324137932e-67 2.249507 589 0.02787374 481 0.00022358960279625776 1.378644 83 113 0.008296681 GO Biological Process regulation of lymphocyte differentiation 180 6.759388e-67 4.941488149555555e-65 2.024781 730 0.0345464 276 3.1413603433333334e-7 1.423046 116 153 0.01159536 GO Biological Process positive regulation of leukocyte differentiation 181 1.653601e-66 1.202195334751381e-64 2.04651 707 0.03345795 226 1.5740824912831858e-8 1.493028 105 132 0.0104958 GO Biological Process antigen receptor-mediated signaling pathway 183 5.126906e-66 3.686609620437158e-64 2.085091 671 0.03175429 410 0.00004916285847317073 1.331324 122 172 0.01219512 GO Biological Process cellular response to biotic stimulus 191 3.09409e-64 2.131682215183246e-62 2.061055 671 0.03175429 285 6.514046672280702e-7 1.386383 130 176 0.0129948 GO Biological Process cellular response to molecule of bacterial origin 201 1.628668e-63 1.066250856318408e-61 2.129986 614 0.02905684 316 0.0000026168512094303802 1.392575 115 155 0.0114954 GO Biological Process T cell differentiation 207 1.56108e-62 9.923793101449276e-61 2.009347 695 0.03289007 243 4.949112355020576e-8 1.484099 102 129 0.01019592 GO Biological Process regulation of leukocyte mediated immunity 210 1.053322e-61 6.600316284761904e-60 2.164252 575 0.02721121 462 0.00014602169176839826 1.325595 113 160 0.01129548 GO Biological Process cellular response to lipopolysaccharide 218 3.088094e-61 1.8640471993577983e-59 2.115574 601 0.02844163 290 9.337354144827586e-7 1.417288 111 147 0.01109556 GO Biological Process regulation of intrinsic apoptotic signaling pathway 230 2.343077e-58 1.3405456627391304e-56 2.258374 495 0.0234253 989 0.02315562220121335 1.223044 101 155 0.01009596 GO Biological Process interferon-gamma-mediated signaling pathway 232 3.222181e-58 1.827615507715517e-56 3.087405 284 0.01343997 491 0.00026978764042769857 1.495694 51 64 0.005097961 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 42 4.059197e-40 1.670069622857143e-38 2.037727 426 0.02015995 64 0.00013260026700000001 1.394797 81 109 0.008096761 GO Cellular Component uropod 81 4.741279e-22 1.0114728533333333e-20 4.240222 68 0.003218021 99 0.004846661236363636 1.876949 13 13 0.00129948 GO Cellular Component MHC protein complex 103 1.140233e-16 1.912934586407767e-15 4.244428 50 0.002366192 85 0.0012708191774117646 1.783102 19 20 0.00189924 GO Cellular Component immunological synapse 107 3.01423e-16 4.86784059813084e-15 2.052155 159 0.00752449 62 0.00010682652077419355 1.706317 30 33 0.0029988 GO Cellular Component MHC class II protein complex 144 3.791278e-12 4.5495336e-11 4.916599 30 0.001419715 127 0.015180030992125983 1.751819 14 15 0.00139944 GO Molecular Function cytokine receptor activity 13 1.46461e-48 4.75660263076923e-46 2.383356 367 0.01736785 90 0.0017619311384444445 1.38731 68 92 0.006797281 GO Molecular Function non-membrane spanning protein tyrosine kinase activity 52 1.321465e-30 1.0729279288461538e-28 2.281069 248 0.01173631 79 0.0007162911592405063 1.545723 42 51 0.004198321 GO Molecular Function protein phosphorylated amino acid binding 61 3.208139e-27 2.2204529275409836e-25 2.207778 235 0.0111211 93 0.0033661247855913973 1.535686 36 44 0.003598561 GO Molecular Function phosphotyrosine binding 66 2.85094e-25 1.8237376787878788e-23 2.28256 202 0.009559415 121 0.03366330400330578 1.501559 28 35 0.00279888 GO Molecular Function antigen binding 80 7.959473e-21 4.20061187575e-19 2.231987 172 0.0081397 106 0.011438266298113207 1.407712 48 64 0.004798081 GO Molecular Function MHC protein complex binding 100 1.04528e-17 4.41317216e-16 3.303146 73 0.00345464 114 0.02059468638245614 1.689254 18 20 0.00179928 GO Molecular Function MHC class II protein complex binding 146 3.271745e-13 9.461169445205479e-12 3.329731 52 0.00246084 92 0.0019233316410869564 1.876949 16 16 0.00159936 Human Phenotype Abnormality of lymphocytes 3 8.738845e-53 1.9438104228333334e-49 2.193179 476 0.02252615 22 0.0032956946049999994 1.33682 99 139 0.009896042 Human Phenotype Decreased antibody level in blood 5 4.056869e-45 5.4142973674000005e-42 2.420316 330 0.01561687 20 0.0029285604919500005 1.442046 63 82 0.006297481 Human Phenotype Abnormal immunoglobulin level 6 5.063794e-45 5.631782893666666e-42 2.296625 366 0.01732052 54 0.007764644720185184 1.353569 75 104 0.007497001 Human Phenotype Abnormality of B cell physiology 7 8.472657e-45 8.076862880142858e-42 2.287986 367 0.01736785 60 0.008624273061166667 1.345737 76 106 0.007596961 Human Phenotype Abnormality of the lymph nodes 16 1.23692e-24 5.158729475e-22 2.313957 191 0.009038853 34 0.0040995496994117656 1.539098 41 50 0.004098361 Human Phenotype Abnormality of cells of the lymphoid lineage 19 8.002352e-23 2.8105102576842104e-20 2.294832 179 0.008470967 57 0.008680429224385965 1.535686 36 44 0.003598561 Human Phenotype Lymphadenopathy 24 3.662511e-21 1.018330662625e-18 2.244004 173 0.008187024 37 0.005006398411351351 1.571399 36 43 0.003598561 Human Phenotype Recurrent upper respiratory tract infections 28 9.320607e-20 2.2213003753928573e-17 2.016831 206 0.00974871 21 0.003016927170142857 1.457105 59 76 0.005897641 Human Phenotype Lymphopenia 34 4.044823e-18 7.938559964411765e-16 2.153488 160 0.007571814 83 0.014255481661445784 1.519435 34 42 0.003398641 Human Phenotype IgG deficiency 41 2.27757e-16 3.7068840512195124e-14 2.36384 117 0.005536889 111 0.03477278056666667 1.564124 25 30 0.002499 Mouse Phenotype Single KO abnormal adaptive immunity 1 0 0 2.028943 4545 0.2150868 4 2.116230087475e-35 1.32421 896 1270 0.08956417 Mouse Phenotype Single KO abnormal cell-mediated immunity 1 0 0 2.040702 4494 0.2126733 5 2.9222679158e-35 1.325877 883 1250 0.08826469 Mouse Phenotype Single KO abnormal immune cell physiology 1 0 0 2.043897 4476 0.2118215 7 3.3889010485714283e-35 1.3266 875 1238 0.08746501 Mouse Phenotype Single KO abnormal leukocyte physiology 1 0 0 2.042435 4439 0.2100705 9 2.5192657004444443e-34 1.325451 858 1215 0.08576569 Mouse Phenotype Single KO abnormal lymphocyte physiology 1 0 0 2.23915 3546 0.1678103 13 1.950017664846154e-32 1.376719 633 863 0.06327469 Mouse Phenotype Single KO abnormal immune serum protein physiology 1 0 0 2.102062 3432 0.1624154 29 4.263975995517241e-24 1.310885 660 945 0.06597361 Mouse Phenotype Single KO abnormal T cell physiology 1 0 0 2.463163 2348 0.1111164 32 6.7226601965625e-24 1.415756 396 525 0.03958417 Mouse Phenotype Single KO decreased lymphocyte cell number 23 1.417297e-308 5.642690708260869e-306 2.021801 3201 0.1514836 28 4.209142593928571e-24 1.336055 578 812 0.05777689 Mouse Phenotype Single KO abnormal T cell morphology 24 1.429781e-307 5.455210257083333e-305 2.031388 3158 0.1494487 57 1.2095764042456141e-18 1.291955 572 831 0.05717713 Mouse Phenotype Single KO abnormal professional antigen presenting cell physiology 26 1.790116e-298 6.304650850769232e-296 2.028644 3082 0.1458521 10 1.1385456677e-32 1.381735 625 849 0.06247501 Mouse Phenotype Single KO abnormal hemopoiesis 27 4.493967e-295 1.5241205858888887e-292 2.014593 3098 0.1466092 37 2.0631329816756754e-22 1.340678 525 735 0.05247901 Mouse Phenotype Single KO abnormal cytokine secretion 31 1.007955e-283 2.9773690112903225e-281 2.3315 2205 0.1043491 78 4.2796108241025643e-16 1.327999 404 571 0.04038385 Mouse Phenotype Single KO abnormal B cell physiology 34 9.692696e-260 2.610471096235294e-257 2.233455 2207 0.1044437 47 2.4096392221276597e-20 1.378276 398 542 0.03978409 Mouse Phenotype Single KO increased lymphocyte cell number 35 1.038074e-258 2.715898176571429e-256 2.109412 2478 0.1172685 80 5.37792212475e-16 1.315705 429 612 0.04288285 Mouse Phenotype Single KO abnormal lymphopoiesis 38 5.656316e-255 1.3630233055789473e-252 2.232283 2171 0.1027401 21 1.544026305047619e-25 1.471356 341 435 0.03408637 Mouse Phenotype Single KO abnormal B cell morphology 39 2.018802e-245 4.740043567692307e-243 2.076712 2441 0.1155175 44 1.0098626796818181e-20 1.378013 406 553 0.04058377 Mouse Phenotype Single KO abnormal alpha-beta T cell morphology 40 8.555065e-244 1.958468255125e-241 2.058519 2474 0.1170792 116 3.7691561868103445e-12 1.273536 420 619 0.04198321 Mouse Phenotype Single KO abnormal leukopoiesis 42 8.356722e-240 1.8219643655714287e-237 2.098989 2333 0.1104065 25 2.73184700196e-24 1.424144 390 514 0.03898441 Mouse Phenotype Single KO abnormal mature B cell morphology 43 3.55015e-227 7.56016826744186e-225 2.100353 2214 0.104775 50 1.24801925096e-19 1.389628 365 493 0.03648541 Mouse Phenotype Single KO abnormal B cell number 44 8.094832e-226 1.6846449232727274e-223 2.098845 2205 0.1043491 53 3.270728359245283e-19 1.386644 362 490 0.03618553 Mouse Phenotype abnormal professional antigen presenting cell physiology 1 0 0 2.005324 3709 0.1755241 11 8.369472543545454e-37 1.366551 747 1026 0.07467013 Mouse Phenotype abnormal lymphocyte physiology 1 0 0 2.128752 4281 0.2025933 14 4.8599785442142855e-34 1.341907 780 1091 0.07796881 Mouse Phenotype abnormal lymphopoiesis 1 0 0 2.20434 2959 0.1400312 25 2.01696102432e-29 1.412757 490 651 0.04898041 Mouse Phenotype abnormal leukopoiesis 1 0 0 2.098834 3194 0.1511523 27 1.8380799410000002e-28 1.377258 554 755 0.05537785 Mouse Phenotype abnormal immune serum protein physiology 1 0 0 2.029128 4095 0.1937911 32 2.4614737731562502e-26 1.291821 797 1158 0.07966813 Mouse Phenotype abnormal T cell physiology 1 0 0 2.28355 2943 0.1392741 42 7.866597303571427e-25 1.36726 507 696 0.05067973 Mouse Phenotype abnormal cytokine secretion 1 0 0 2.249264 2733 0.129336 97 4.038479661030928e-17 1.300029 498 719 0.04978009 Mouse Phenotype abnormal B cell morphology 37 1.297866e-311 3.35375589891833e-309 2.063579 3087 0.1460887 48 3.842197403125e-24 1.355142 522 723 0.05217913 Mouse Phenotype increased lymphocyte cell number 38 1.054669e-308 2.653602712894737e-306 2.042344 3131 0.1481709 79 1.2877480951898733e-19 1.30468 554 797 0.05537785 Mouse Phenotype abnormal B cell physiology 39 1.096075e-304 2.6870700192307693e-302 2.184153 2682 0.1269225 50 1.0643909455200001e-23 1.364548 490 674 0.04898041 Mouse Phenotype abnormal mature B cell morphology 41 3.155228e-298 7.357837782439025e-296 2.098949 2858 0.1352515 56 4.1191895325000007e-23 1.364794 477 656 0.04768093 Mouse Phenotype abnormal B cell number 42 8.014424e-297 1.8244263777142856e-294 2.097778 2849 0.1348256 58 1.054932057e-22 1.362441 474 653 0.04738105 Mouse Phenotype abnormal T cell activation 46 7.326584e-271 1.5228145570434782e-268 2.46418 1904 0.09010459 83 6.009579221204819e-19 1.418037 309 409 0.03088764 Mouse Phenotype decreased B cell number 47 4.177014e-270 8.497112947659575e-268 2.207472 2345 0.1109744 37 6.056596333783783e-26 1.449487 373 483 0.03728509 Mouse Phenotype abnormal humoral immune response 48 2.717607e-269 5.413133443125e-267 2.185027 2388 0.1130093 77 8.433635172857142e-20 1.35366 432 599 0.04318273 Mouse Phenotype abnormal immunoglobulin level 49 3.639435e-257 7.101354701020408e-255 2.220148 2213 0.1047277 78 9.701782047692308e-20 1.368467 401 550 0.04008397 Mouse Phenotype abnormal interleukin secretion 51 1.144123e-250 2.144894118235294e-248 2.235529 2130 0.1007998 190 3.151284465157894e-11 1.280372 367 538 0.03668533 Mouse Phenotype abnormal T cell proliferation 52 4.151777e-244 7.633680749423077e-242 2.491768 1689 0.07992996 104 1.2842831636538462e-16 1.412812 277 368 0.02768892 Mouse Phenotype abnormal CD4-positive, alpha beta T cell morphology 54 3.947126e-239 6.988605867777778e-237 2.110568 2299 0.1087975 116 1.1331153212068967e-15 1.326693 393 556 0.03928429 Mouse Phenotype autoimmune response 55 9.232096e-232 1.604873997381818e-229 2.38606 1740 0.08234348 147 3.577733354489796e-13 1.342571 304 425 0.03038784