# species: Homo sapiens # support: EXP, IMP, ISS, ISM, TAS, IEA, IDA, IGI, ISO, IGC, NAS, IPI, IEP, ISA, RCA, IC # associations retrieved on: 2017-08-17 17:24:44-04 # gofunc built on: 2016-02-08 14:16:26.444801-05 # gene associations file: ftp://ftp.geneontology.org/pub/go/gene-associations/gene_association.goa_human.gz # revision: 12/09/2015 $ # downloaded on: 2015-12-22 08:03:12-05 # GO DAG files from: http://archive.geneontology.org/latest-full/go_201512-termdb-tables.tar.gz # downloaded on: 2015-12-22 05:43:21-05 # translation required: yes # translation info: # authority: ensembl # synergizer db built on: 2015-11-17 14:24:21.26681-05 # synergizer db built from: Ensembl Genes 82 / Metazoa Mart / Plant Mart # namespace: hgnc_symbol # coverage: 99.6% # size of "genespace": 18111 # number of attributes: 19424 # NOTE: the last record consists of all the entities in the # "genespace" that are not associated with any attribute (for # the requested support). # Original number of entities in query: 137 # Number of entities in query: 137 # Total number of entities: 18115 # Original total number of entities: 18111 # Entities not in default gene space: 4 # Total number of attributes: 19424 # Translation required: yes # Translation coverage: 0.995719 # Mode: unordered # Number of simulations: 1000 # Adjusted P-value cutoff: 0.05 # Over/under: over # Evidence codes: EXP, IMP, ISS, ISM, TAS, IEA, IDA, IGI, ISO, IGC, NAS, IPI, IEP, ISA, RCA, IC OVERREPRESENTED ATTRIBUTES N X LOD P P_adj attrib ID attrib name 4 14 1.76105377297449 2.95498817800138e-06 0.011 GO:0009070 serine family amino acid biosynthetic process 9 35 1.69969953908393 3.70881797037306e-12 <0.001 GO:0004812 aminoacyl-tRNA ligase activity 9 35 1.69969953908393 3.70881797037306e-12 <0.001 GO:0016875 ligase activity, forming carbon-oxygen bonds 9 35 1.69969953908393 3.70881797037306e-12 <0.001 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 4 19 1.59179050821548 1.11106687660549e-05 0.025 GO:0046653 tetrahydrofolate metabolic process 9 46 1.54864795933155 5.39477725543745e-11 <0.001 GO:0006418 tRNA aminoacylation for protein translation 9 49 1.51515157934913 9.86933641616706e-11 <0.001 GO:0043038 amino acid activation 9 49 1.51515157934913 9.86933641616706e-11 <0.001 GO:0043039 tRNA aminoacylation 9 64 1.37795031468353 1.20227624320297e-09 <0.001 GO:1901607 alpha-amino acid biosynthetic process 10 77 1.33950729886708 3.13248834659824e-10 <0.001 GO:0008652 cellular amino acid biosynthetic process 5 39 1.33425907793882 1.07659094723342e-05 0.024 GO:0000049 tRNA binding 6 51 1.28964126428201 2.28242512389545e-06 0.01 GO:0022625 cytosolic large ribosomal subunit 6 61 1.20311744087907 6.61478915209424e-06 0.018 GO:0008135 translation factor activity, RNA binding 11 115 1.19172492660052 1.12429284877422e-09 <0.001 GO:0072599 establishment of protein localization to endoplasmic reticulum 10 107 1.17907844563397 8.28251400550514e-09 <0.001 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 10 108 1.17462254279272 9.06949122461817e-09 <0.001 GO:0006613 cotranslational protein targeting to membrane 10 111 1.16151985876364 1.18423484673524e-08 <0.001 GO:0045047 protein targeting to ER 6 67 1.15838990118324 1.14553696095281e-05 0.026 GO:0015934 large ribosomal subunit 10 117 1.13643165551333 1.97228806496275e-08 <0.001 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 10 120 1.12440493276516 2.51772034039316e-08 <0.001 GO:0070972 protein localization to endoplasmic reticulum 9 111 1.11037910546602 1.63488990404428e-07 <0.001 GO:0019083 viral transcription 10 124 1.10886449309508 3.45023467101079e-08 <0.001 GO:0044391 ribosomal subunit 12 167 1.05752888429402 5.20193192734263e-09 <0.001 GO:0044445 cytosolic part 8 111 1.0544670059047 1.99966856673512e-06 0.01 GO:0003735 structural constituent of ribosome 15 218 1.04345302157961 1.05565809942474e-10 <0.001 GO:0006413 translational initiation 18 276 1.02581924742601 3.11580602497033e-12 <0.001 GO:0006412 translation 22 350 1.01982217249681 2.06129836767694e-14 <0.001 GO:0043604 amide biosynthetic process 12 183 1.01460511582882 1.45938544885177e-08 <0.001 GO:0006414 translational elongation 21 339 1.01000609294294 1.13200466427135e-13 <0.001 GO:0006520 cellular amino acid metabolic process 11 171 1.0040034194885 7.2798912664828e-08 <0.001 GO:0006399 tRNA metabolic process 18 296 0.992964158003343 1.0061100986999e-11 <0.001 GO:0043043 peptide biosynthetic process 10 159 0.992177085886901 3.60405401451859e-07 0.002 GO:0006612 protein targeting to membrane 11 177 0.987917954352022 1.03543254476749e-07 <0.001 GO:0000956 nuclear-transcribed mRNA catabolic process 9 148 0.975628947950902 1.87267719400296e-06 0.01 GO:0019058 viral life cycle 10 168 0.966569732867623 5.99491394258695e-07 0.004 GO:0006415 translational termination 11 188 0.959865556067197 1.90885459385748e-07 <0.001 GO:0006402 mRNA catabolic process 12 210 0.950449745560018 6.71781278337974e-08 <0.001 GO:0043241 protein complex disassembly 12 218 0.933094754098855 1.01168110155346e-07 <0.001 GO:0032984 macromolecular complex disassembly 10 190 0.909585310975452 1.84152004882712e-06 0.01 GO:0043624 cellular protein complex disassembly 19 378 0.906610946291685 6.96937699445145e-11 <0.001 GO:0006518 peptide metabolic process 25 516 0.906591863318304 1.10362622239769e-13 <0.001 GO:0043603 cellular amide metabolic process 11 216 0.895568447161652 7.64310701201731e-07 0.004 GO:0006401 RNA catabolic process 12 243 0.882852476683226 3.27549375034584e-07 0.002 GO:0016053 organic acid biosynthetic process 12 243 0.882852476683226 3.27549375034584e-07 0.002 GO:0046394 carboxylic acid biosynthetic process 11 244 0.839408670545303 2.51660255896133e-06 0.01 GO:0090150 establishment of protein localization to membrane 36 928 0.837871708338153 1.79725250998196e-16 <0.001 GO:0010467 gene expression 13 297 0.828920441460036 4.13658100813406e-07 0.003 GO:0072594 establishment of protein localization to organelle 10 232 0.817706464677615 1.08453779850026e-05 0.025 GO:1901605 alpha-amino acid metabolic process 16 391 0.803896749547133 4.48620154562256e-08 <0.001 GO:0034660 ncRNA metabolic process 11 271 0.791226540124266 6.87326731402835e-06 0.018 GO:0006417 regulation of translation 11 275 0.784510537149054 7.89511777814225e-06 0.02 GO:0006605 protein targeting 22 580 0.783637972322772 4.34061115745113e-10 <0.001 GO:0030529 intracellular ribonucleoprotein complex 22 580 0.783637972322772 4.34061115745113e-10 <0.001 GO:1990904 ribonucleoprotein complex 12 322 0.753404363516531 6.19708006310138e-06 0.017 GO:0034655 nucleobase-containing compound catabolic process 11 295 0.75236333923856 1.52473201292349e-05 0.037 GO:0034248 regulation of cellular amide metabolic process 29 857 0.750376550879183 7.65300752660179e-12 <0.001 GO:1901566 organonitrogen compound biosynthetic process 13 364 0.735429811056488 3.98269538398361e-06 0.013 GO:0044270 cellular nitrogen compound catabolic process 13 364 0.735429811056488 3.98269538398361e-06 0.013 GO:0046700 heterocycle catabolic process 44 1502 0.731665153942223 1.14416208065978e-15 <0.001 GO:0003723 RNA binding 18 526 0.725818200387019 9.2505401718217e-08 <0.001 GO:0016071 mRNA metabolic process 14 402 0.725588205709948 2.23012500668595e-06 0.01 GO:1901361 organic cyclic compound catabolic process 13 375 0.721776034314304 5.50085419172561e-06 0.017 GO:0019439 aromatic compound catabolic process 14 415 0.710972601631982 3.22704417921205e-06 0.011 GO:0044283 small molecule biosynthetic process 34 1141 0.705688706653255 2.9117522627602e-12 <0.001 GO:0044822 poly(A) RNA binding 13 390 0.703797141069247 8.38774582818483e-06 0.021 GO:0010608 posttranscriptional regulation of gene expression 25 811 0.695027964041328 1.81940316451235e-09 <0.001 GO:0019752 carboxylic acid metabolic process 18 617 0.652051913529403 9.5788083703571e-07 0.005 GO:0016032 viral process 18 617 0.652051913529403 9.5788083703571e-07 0.005 GO:0044403 symbiosis, encompassing mutualism through parasitism 18 622 0.648319833321459 1.07513223056552e-06 0.006 GO:0044764 multi-organism cellular process 40 1575 0.648194849387905 3.4270195239157e-12 <0.001 GO:1901564 organonitrogen compound metabolic process 17 592 0.6426422713928 2.43616764863269e-06 0.01 GO:0022411 cellular component disassembly 25 926 0.632846220934996 2.57577980140175e-08 <0.001 GO:0043436 oxoacid metabolic process 25 942 0.62479879554492 3.59922718807198e-08 <0.001 GO:0006082 organic acid metabolic process 19 725 0.604559296187749 2.29158194263728e-06 0.01 GO:0044419 interspecies interaction between organisms 16 628 0.585513873909567 2.17734305231293e-05 0.047 GO:1902580 single-organism cellular localization 58 3040 0.568198196935601 1.39668718684721e-12 <0.001 GO:0005829 cytosol 122 12591 0.543067538373659 4.7296605783282e-08 <0.001 GO:0044424 intracellular part 95 7494 0.506877209915895 2.93967771230246e-11 <0.001 GO:0044444 cytoplasmic part 28 1380 0.505094303725827 1.26788538123818e-06 0.007 GO:0071822 protein complex subunit organization 25 1277 0.48101499831836 9.71410510300226e-06 0.023 GO:0051704 multi-organism process 71 4802 0.478619480257198 2.31076999647524e-10 <0.001 GO:0034641 cellular nitrogen compound metabolic process 75 5367 0.461747891394963 6.83499642973217e-10 <0.001 GO:1901363 heterocyclic compound binding 75 5433 0.454100260399796 1.25693136738164e-09 <0.001 GO:0097159 organic cyclic compound binding 35 1995 0.451759486594105 1.36791139030493e-06 0.007 GO:0043933 macromolecular complex subunit organization 45 2725 0.448302703196683 1.33045334598875e-07 <0.001 GO:0065010 extracellular membrane-bounded organelle 45 2725 0.448302703196683 1.33045334598875e-07 <0.001 GO:0070062 extracellular exosome 45 2738 0.445832333423983 1.53169937396535e-07 <0.001 GO:0043230 extracellular organelle 45 2738 0.445832333423983 1.53169937396535e-07 <0.001 GO:1903561 extracellular vesicle 71 5153 0.435878871663143 6.42910519557937e-09 <0.001 GO:0006807 nitrogen compound metabolic process 37 2202 0.435335020820491 1.75919095043239e-06 0.01 GO:0044281 small molecule metabolic process 54 3563 0.429918304184391 7.08855075458348e-08 <0.001 GO:0003676 nucleic acid binding 62 4325 0.425378442875879 3.13874919080219e-08 <0.001 GO:0046483 heterocycle metabolic process 60 4163 0.421547876151228 5.17329024607224e-08 <0.001 GO:0009058 biosynthetic process 59 4090 0.418677014930332 7.09895320581885e-08 <0.001 GO:1901576 organic substance biosynthetic process 98 8875 0.417326927190401 6.32425209413753e-08 <0.001 GO:0043227 membrane-bounded organelle 61 4343 0.41012591082064 9.81654405558874e-08 <0.001 GO:0006725 cellular aromatic compound metabolic process 57 3972 0.409178153538859 1.69858033314725e-07 <0.001 GO:0044249 cellular biosynthetic process 63 4563 0.406998249479544 9.7836190319649e-08 <0.001 GO:1901360 organic cyclic compound metabolic process 49 3290 0.405339720399966 7.07054291964926e-07 0.004 GO:0031982 vesicle 47 3164 0.398301214089744 1.46387541516825e-06 0.008 GO:0031988 membrane-bounded vesicle 51 3544 0.392463864446972 1.07505310159159e-06 0.006 GO:0044421 extracellular region part 115 12266 0.391251857081774 1.23474101400818e-05 0.027 GO:0009987 cellular process 102 9826 0.389319003544932 7.96134797447714e-07 0.005 GO:0043226 organelle 47 3219 0.389095810616603 2.40461915894003e-06 0.01 GO:0016070 RNA metabolic process 57 4142 0.385438414894113 7.38217867626198e-07 0.004 GO:0006139 nucleobase-containing compound metabolic process 51 3735 0.363581529712823 5.33086106063115e-06 0.017 GO:0090304 nucleic acid metabolic process 45 3205 0.36291811374155 1.25815819324854e-05 0.028 GO:0044271 cellular nitrogen compound biosynthetic process 48 3577 0.346058336396495 1.9267218109462e-05 0.043 GO:0044428 nuclear part 55 4292 0.338763465558681 1.302959300004e-05 0.028 GO:0032991 macromolecular complex 86 8110 0.318810347969486 1.58717771893987e-05 0.038 GO:0044238 primary metabolic process 85 7974 0.318626975484049 1.55253378711544e-05 0.037 GO:0044237 cellular metabolic process