# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- AAA PF00004.29 CCP38037.1 - 5.1e-29 101.4 2.4 2.1e-28 99.4 0.0 2.9 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCP38037.1 - 0.00014 21.6 0.0 0.00033 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain DUF815 PF05673.13 CCP38037.1 - 0.0008 18.6 0.0 0.0016 17.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CCP38037.1 - 0.007 16.8 0.1 2.7 8.3 0.1 2.8 2 1 0 3 3 3 1 AAA ATPase domain Sigma54_activ_2 PF14532.6 CCP38037.1 - 0.01 16.0 0.0 20 5.3 0.0 3.5 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_22 PF13401.6 CCP38037.1 - 0.015 15.6 0.1 1.5 9.1 0.1 2.8 1 1 1 2 2 2 0 AAA domain AAA_2 PF07724.14 CCP38037.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 CCP38037.1 - 0.054 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain GIT1_C PF12205.8 CCP38037.1 - 0.18 11.9 2.3 0.99 9.5 0.3 2.9 3 0 0 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term Ribosomal_L34 PF00468.17 CCP38038.1 - 2e-11 43.7 16.6 2.4e-11 43.4 16.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L34 TPR_1 PF00515.28 CCP38039.1 - 9.1e-10 37.9 11.4 7.1e-05 22.5 2.9 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCP38039.1 - 7.8e-09 35.0 5.1 0.00087 19.2 0.5 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCP38039.1 - 1.4e-08 34.3 12.6 1.2e-05 25.2 1.2 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCP38039.1 - 5e-07 29.9 1.1 2.4e-06 27.7 0.6 2.3 2 2 0 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.10 CCP38039.1 - 9.9e-07 28.1 0.6 1.2e-06 27.9 0.6 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.6 CCP38039.1 - 7.6e-06 26.0 1.0 7.6e-06 26.0 1.0 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCP38039.1 - 4.3e-05 23.2 0.5 0.00016 21.5 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCP38039.1 - 5.8e-05 23.5 0.9 0.00075 20.0 0.6 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCP38039.1 - 7.5e-05 22.9 2.4 0.086 13.1 0.4 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CCP38039.1 - 0.00028 20.5 3.8 0.00035 20.2 1.7 2.3 1 1 1 2 2 2 1 TPR repeat TPR_10 PF13374.6 CCP38039.1 - 0.0022 17.8 1.8 0.019 14.8 0.3 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCP38039.1 - 0.0097 16.5 1.9 0.45 11.3 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Acetyltransf_10 PF13673.7 CCP38040.1 - 1.1e-14 54.5 0.0 1.8e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCP38040.1 - 1.7e-13 50.8 0.0 2.3e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCP38040.1 - 1.1e-11 45.0 0.1 2.9e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCP38040.1 - 7.2e-05 22.9 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCP38040.1 - 0.00056 19.8 0.0 0.0016 18.4 0.0 1.8 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 CCP38040.1 - 0.0024 17.4 0.3 0.0035 16.8 0.3 1.4 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 CCP38040.1 - 0.0059 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PSI_PsaF PF02507.15 CCP38041.1 - 1.5e-78 262.5 0.0 1.9e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Photosystem I reaction centre subunit III GPR15L PF15854.5 CCP38041.1 - 0.059 13.6 0.2 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 Transposase_20 PF02371.16 CCP38041.1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family PSI_PsaJ PF01701.18 CCP38042.1 - 1e-16 61.1 1.2 1.3e-16 60.8 1.2 1.1 1 0 0 1 1 1 1 Photosystem I reaction centre subunit IX / PsaJ Phycobilisome PF00502.19 CCP38043.1 - 4.2e-50 169.7 0.0 4.7e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Phycobilisome protein ACP_syn_III_C PF08541.10 CCP38044.1 - 1.6e-33 114.7 0.1 3.6e-33 113.6 0.1 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CCP38044.1 - 2.4e-30 104.2 1.7 6.1e-30 102.9 0.7 2.1 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CCP38044.1 - 0.00017 21.0 0.1 0.00032 20.1 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Chal_sti_synt_N PF00195.19 CCP38044.1 - 0.00024 20.6 0.4 0.011 15.1 0.3 2.3 1 1 1 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain Chal_sti_synt_C PF02797.15 CCP38044.1 - 0.00047 20.2 0.0 0.00085 19.3 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain PsbX PF06596.11 CCP38045.1 - 1.5e-16 60.1 2.0 1.5e-16 60.1 2.0 1.0 1 0 0 1 1 1 1 Photosystem II reaction centre X protein (PsbX) BatA PF07584.11 CCP38045.1 - 0.038 14.4 0.1 0.038 14.4 0.1 1.0 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal NOD PF06816.13 CCP38045.1 - 0.11 12.2 0.3 0.14 11.8 0.3 1.3 1 1 0 1 1 1 0 NOTCH protein Carboxyl_trans PF01039.22 CCP38046.1 - 1.2e-20 73.7 0.0 1.4e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain zf-ACC PF17848.1 CCP38046.1 - 1.5e-07 31.4 4.0 1.5e-07 31.4 4.0 2.4 3 0 0 3 3 3 1 Acetyl-coA carboxylase zinc finger domain zf-ribbon_3 PF13248.6 CCP38046.1 - 0.043 13.2 1.2 2.2 7.8 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 CCP38046.1 - 0.077 12.7 2.0 3.8 7.2 0.9 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Tmemb_55A PF09788.9 CCP38046.1 - 0.088 11.9 0.4 0.14 11.3 0.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A zf_UBZ PF18439.1 CCP38046.1 - 0.21 11.2 1.6 1.9 8.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cytochrom_C550 PF14495.6 CCP38047.1 - 3.9e-59 198.2 0.0 4.5e-59 198.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c-550 domain Cytochrom_C PF00034.21 CCP38047.1 - 1.1e-06 29.6 0.0 1.5e-06 29.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CCP38047.1 - 3.5e-05 24.0 0.1 7.4e-05 23.0 0.1 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C1 PF02167.15 CCP38047.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C1 family DUF2428 PF10350.9 CCP38047.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) Cytochrome_CBB3 PF13442.6 CCP38048.1 - 2.6e-16 59.7 0.1 3.3e-16 59.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CCP38048.1 - 1.3e-08 35.9 1.4 3.1e-07 31.5 1.4 2.0 1 1 0 1 1 1 1 Cytochrome c Cytochrom_C550 PF14495.6 CCP38048.1 - 1.4e-08 34.5 0.2 4.8e-06 26.3 0.1 2.1 1 1 1 2 2 2 2 Cytochrome c-550 domain YbgS PF13985.6 CCP38048.1 - 0.00048 20.4 1.4 0.37 11.1 0.4 2.0 1 1 1 2 2 2 2 YbgS-like protein CPSase_sm_chain PF00988.22 CCP38049.1 - 5.3e-50 168.5 0.6 2.1e-49 166.6 0.1 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CCP38049.1 - 2.8e-45 154.5 0.2 5.7e-45 153.4 0.1 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCP38049.1 - 5.1e-07 29.7 1.1 4.8e-05 23.2 0.2 2.5 1 1 1 2 2 2 2 Peptidase C26 GUN4 PF05419.12 CCP38050.1 - 2e-48 164.0 0.9 3.2e-48 163.4 0.9 1.3 1 0 0 1 1 1 1 GUN4-like DUF5314 PF17241.2 CCP38050.1 - 0.035 13.8 2.4 0.046 13.4 1.8 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5314) DUF3685 PF12452.8 CCP38051.1 - 4.5e-23 81.9 4.8 7.5e-23 81.2 4.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3685) Humanin PF15040.6 CCP38051.1 - 0.032 13.7 1.0 0.082 12.4 1.0 1.6 1 0 0 1 1 1 0 Humanin family DUF3800 PF12686.7 CCP38051.1 - 0.49 11.0 3.3 1.2 9.8 3.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) DUF5408 PF17402.2 CCP38051.1 - 9.1 6.2 10.8 11 6.0 1.2 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5408) Ycf54 PF10674.9 CCP38052.1 - 1.5e-36 124.5 0.2 1.7e-36 124.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2488) DUF3153 PF11353.8 CCP38052.1 - 0.063 12.8 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3153) E1_4HB PF16191.5 CCP38052.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle LysR_substrate PF03466.20 CCP38053.1 - 5e-41 140.4 0.0 6.4e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CCP38053.1 - 5.4e-22 77.5 0.0 1.1e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 CCP38053.1 - 8.7e-08 31.5 0.0 1.7e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 PBP superfamily domain PsbY PF06298.11 CCP38054.1 - 1.8e-17 62.9 1.1 2e-17 62.8 1.1 1.0 1 0 0 1 1 1 1 Photosystem II protein Y (PsbY) Ribosomal_L32p PF01783.23 CCP38055.1 - 1.9e-08 34.4 0.9 2.2e-08 34.2 0.9 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family Lactamase_B_4 PF13691.6 CCP38056.1 - 0.03 14.0 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease Ribosomal_L21p PF00829.21 CCP38057.1 - 6.1e-33 113.1 0.7 6.7e-33 113.0 0.7 1.0 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein FtsK_alpha PF17854.1 CCP38057.1 - 0.06 13.5 0.0 0.078 13.1 0.0 1.2 1 0 0 1 1 1 0 FtsK alpha domain Ribosomal_L27 PF01016.19 CCP38058.1 - 5.6e-34 116.0 6.5 6.3e-34 115.8 6.5 1.0 1 0 0 1 1 1 1 Ribosomal L27 protein RNase_E_G PF10150.9 CCP38059.1 - 7e-81 271.6 4.4 1.2e-80 270.9 4.4 1.4 1 0 0 1 1 1 1 Ribonuclease E/G family S1 PF00575.23 CCP38059.1 - 1.2e-05 25.5 0.2 2.8e-05 24.4 0.2 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Photo_RC PF00124.19 CCP38060.1 - 3.4e-94 314.9 14.1 4.1e-94 314.6 14.1 1.0 1 0 0 1 1 1 1 Photosynthetic reaction centre protein DUF1257 PF06868.11 CCP38061.1 - 2.8e-18 66.1 0.7 3.3e-18 65.8 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1257) STb_secrete PF09075.10 CCP38061.1 - 0.21 11.7 0.1 16 5.6 0.0 2.3 2 0 0 2 2 2 0 Heat-stable enterotoxin B, secretory DsbD PF02683.15 CCP38062.1 - 4.7e-24 85.5 19.0 1.1e-23 84.3 19.0 1.5 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region ResB PF05140.14 CCP38063.1 - 1.7e-62 211.8 2.1 5.1e-51 173.9 1.1 2.0 1 1 0 2 2 2 2 ResB-like family GATase PF00117.28 CCP38064.1 - 4.8e-51 173.3 0.0 5.3e-51 173.1 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCP38064.1 - 1.3e-11 44.7 0.1 8.7e-11 42.0 0.1 1.9 1 1 0 1 1 1 1 Peptidase C26 ThiG PF05690.14 CCP38065.1 - 2.7e-102 341.3 0.8 3.1e-102 341.1 0.8 1.0 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CCP38065.1 - 0.00011 21.8 0.2 0.00024 20.6 0.1 1.5 2 0 0 2 2 2 1 Histidine biosynthesis protein IMPDH PF00478.25 CCP38065.1 - 0.0035 16.4 0.5 0.0048 15.9 0.5 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCP38065.1 - 0.0047 16.0 0.1 0.0085 15.2 0.1 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 CCP38065.1 - 0.0053 16.0 0.3 0.051 12.8 0.1 2.2 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase NMO PF03060.15 CCP38065.1 - 0.019 14.4 0.2 0.026 13.9 0.2 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.21 CCP38065.1 - 0.034 13.4 0.2 0.059 12.6 0.2 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase LDcluster4 PF18306.1 CCP38065.1 - 0.046 13.3 0.1 0.089 12.4 0.1 1.4 1 0 0 1 1 1 0 SLOG cluster4 family TIC20 PF16166.5 CCP38066.1 - 2e-11 44.0 10.0 2e-11 44.0 10.0 1.4 1 1 0 1 1 1 1 Chloroplast import apparatus Tic20-like DUF3082 PF11282.8 CCP38066.1 - 0.033 14.4 1.4 0.41 10.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3082) DUF3951 PF13131.6 CCP38066.1 - 0.047 13.9 9.9 0.36 11.1 1.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) Lig_chan PF00060.26 CCP38066.1 - 0.3 10.9 3.0 6.4 6.6 0.2 2.3 2 0 0 2 2 2 0 Ligand-gated ion channel Ribosomal_S6 PF01250.17 CCP38067.1 - 4.8e-20 71.6 1.6 5.4e-20 71.5 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S6 ATLF PF07737.11 CCP38067.1 - 0.034 13.4 1.0 0.038 13.3 1.0 1.1 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain Response_reg PF00072.24 CCP38068.1 - 2.4e-31 108.2 0.0 1.5e-30 105.7 0.0 2.0 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CCP38068.1 - 3.6e-27 94.2 0.0 7.9e-27 93.2 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Photo_RC PF00124.19 CCP38069.1 - 1e-74 251.1 15.2 1.2e-74 250.8 15.2 1.0 1 0 0 1 1 1 1 Photosynthetic reaction centre protein PSII PF00421.19 CCP38070.1 - 7.7e-149 496.6 12.6 9.6e-149 496.3 12.6 1.1 1 0 0 1 1 1 1 Photosystem II protein Chloroa_b-bind PF00504.21 CCP38071.1 - 0.017 15.6 0.0 0.021 15.4 0.0 1.1 1 0 0 1 1 1 0 Chlorophyll A-B binding protein UPRTase PF14681.6 CCP38072.1 - 0.00018 21.1 0.4 0.0003 20.3 0.4 1.3 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase AKAP95 PF04988.12 CCP38072.1 - 0.0079 16.4 0.6 0.0079 16.4 0.6 1.7 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) YGGT PF02325.17 CCP38073.1 - 1.6e-13 50.8 3.9 2.2e-13 50.4 3.9 1.1 1 0 0 1 1 1 1 YGGT family Ribosomal_S16 PF00886.19 CCP38074.1 - 8.5e-19 67.4 0.1 1e-18 67.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 PSRP-3_Ycf65 PF04839.13 CCP38075.1 - 4.8e-29 100.3 4.4 7e-29 99.8 4.4 1.3 1 0 0 1 1 1 1 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) CCB1 PF12046.8 CCP38075.1 - 0.0058 16.0 0.0 0.0066 15.8 0.0 1.1 1 0 0 1 1 1 1 Cofactor assembly of complex C subunit B HLH PF00010.26 CCP38075.1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Casc1_N PF15927.5 CCP38076.1 - 0.38 10.4 3.8 0.81 9.3 3.8 1.5 1 1 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Cpn60_TCP1 PF00118.24 CCP38077.1 - 5.6e-96 322.1 21.1 1.2e-95 321.0 21.1 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family FtsK_gamma PF09397.10 CCP38077.1 - 0.11 12.4 0.0 0.38 10.6 0.0 1.9 1 0 0 1 1 1 0 Ftsk gamma domain tRNA-synt_His PF13393.6 CCP38078.1 - 6.8e-43 147.1 0.0 9.9e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 CCP38078.1 - 9e-18 64.9 0.0 1.5e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCP38078.1 - 6.2e-14 51.9 0.3 1.4e-13 50.8 0.3 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 CCP38078.1 - 9.4e-07 28.2 0.0 4.9e-06 25.8 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CCP38078.1 - 0.0043 16.6 0.0 0.11 12.0 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) Pesticin PF16754.5 CCP38078.1 - 0.033 14.1 0.2 0.063 13.2 0.2 1.4 1 0 0 1 1 1 0 Bacterial toxin homologue of phage lysozyme, C-term Psb28 PF03912.14 CCP38079.1 - 3.8e-45 152.5 0.2 4.3e-45 152.4 0.2 1.0 1 0 0 1 1 1 1 Psb28 protein tRNA_synthFbeta PF17759.1 CCP38080.1 - 3e-31 108.5 0.0 4.9e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 CCP38080.1 - 1.7e-16 60.3 1.9 5e-16 58.9 1.9 1.8 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 CCP38080.1 - 7.4e-15 55.0 1.4 4.4e-13 49.3 0.0 3.5 3 0 0 3 3 3 1 tRNA synthetase B5 domain FDX-ACB PF03147.14 CCP38080.1 - 7.4e-11 42.3 0.1 3.2e-10 40.3 0.1 2.1 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain PhetRS_B1 PF18262.1 CCP38080.1 - 0.034 14.4 0.3 0.19 12.0 0.0 2.4 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain S1 PF00575.23 CCP38081.1 - 5.7e-34 116.3 3.5 4.3e-16 59.0 1.6 3.1 3 0 0 3 3 3 3 S1 RNA binding domain DUF2110 PF09883.9 CCP38081.1 - 3.6e-06 26.8 0.8 0.019 14.5 0.0 2.3 1 1 1 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2110) S1_2 PF13509.6 CCP38081.1 - 0.00023 21.2 2.4 0.23 11.5 0.4 4.0 3 2 0 3 3 3 2 S1 domain FtsK_gamma PF09397.10 CCP38081.1 - 0.023 14.5 0.2 0.63 9.9 0.0 2.5 2 0 0 2 2 2 0 Ftsk gamma domain MRP-S35 PF10246.9 CCP38081.1 - 0.057 13.4 0.3 6.1 6.8 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal protein MRP-S35 RNA_pol_Rbc25 PF08292.12 CCP38081.1 - 1.7 8.9 6.0 8.4 6.6 0.0 3.1 4 0 0 4 4 4 0 RNA polymerase III subunit Rpc25 ThiS PF02597.20 CCP38082.1 - 3.9e-09 37.0 0.0 4.8e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 ThiS family Response_reg PF00072.24 CCP38083.1 - 2.4e-28 98.5 0.1 7.5e-28 96.9 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 CCP38083.1 - 2e-16 59.3 0.5 2.8e-15 55.6 0.6 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CCP38083.1 - 0.00078 19.1 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 TnsD PF15978.5 CCP38083.1 - 0.012 14.6 0.8 0.022 13.8 0.9 1.3 1 1 0 1 1 1 0 Tn7-like transposition protein D KORA PF16509.5 CCP38083.1 - 0.023 15.0 0.1 0.046 14.0 0.1 1.5 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor HTH_23 PF13384.6 CCP38083.1 - 0.038 13.8 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 CCP38084.1 - 0.0069 16.3 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Cytochrome_B PF00033.19 CCP38085.1 - 3.4e-85 284.6 15.5 3.9e-85 284.4 15.5 1.0 1 0 0 1 1 1 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 CCP38085.1 - 4.2e-39 134.3 8.0 4.2e-39 134.3 8.0 1.4 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.20 CCP38085.1 - 7.3e-05 22.4 3.7 7.3e-05 22.4 3.7 2.1 1 1 1 2 2 2 2 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CCP38085.1 - 0.00015 22.3 4.8 0.00015 22.3 4.8 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4405) DUF373 PF04123.13 CCP38085.1 - 0.28 10.6 5.0 0.39 10.1 5.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Cytochrom_B_C PF00032.17 CCP38086.1 - 8.3e-18 64.6 0.7 1.3e-17 63.9 0.7 1.3 1 0 0 1 1 1 1 Cytochrome b(C-terminal)/b6/petD Ribosomal_L12 PF00542.19 CCP38087.1 - 1.4e-27 95.9 10.6 5.1e-27 94.0 7.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CCP38087.1 - 3.6e-13 49.0 9.5 6.9e-13 48.1 0.7 2.7 3 0 0 3 3 3 2 Ribosomal protein L7/L12 dimerisation domain DUF4375 PF14300.6 CCP38087.1 - 0.028 14.7 0.3 0.99 9.7 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) DAHP_snth_FXD PF18152.1 CCP38087.1 - 0.034 14.0 2.0 0.084 12.7 0.3 2.5 2 1 1 3 3 3 0 DAHP synthase ferredoxin-like domain DNA_pol3_finger PF17657.1 CCP38087.1 - 0.046 13.1 0.1 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial DNA polymerase III alpha subunit finger domain Ribosomal_L1 PF00687.21 CCP38088.1 - 5.1e-45 153.7 0.0 6.3e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF5581 PF17744.1 CCP38088.1 - 0.034 13.5 0.0 0.045 13.1 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5581) Ribosomal_L11_N PF03946.14 CCP38089.1 - 2.7e-28 97.6 0.2 5.4e-28 96.6 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CCP38089.1 - 1.8e-23 82.8 0.9 4e-23 81.7 0.9 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain ThiF PF00899.21 CCP38090.1 - 3.4e-49 167.4 0.0 4.8e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 CCP38090.1 - 5.6e-10 39.7 0.7 4.7e-09 36.7 0.2 2.3 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 CCP38090.1 - 0.0012 19.0 0.4 0.0096 16.0 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Ribosomal_L9_N PF01281.19 CCP38091.1 - 2.6e-15 55.7 0.6 6e-15 54.5 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 CCP38091.1 - 3.5e-13 49.8 1.5 3.5e-13 49.8 1.5 1.9 1 1 1 2 2 2 1 Ribosomal protein L9, C-terminal domain Lebercilin PF15619.6 CCP38091.1 - 0.0024 17.5 1.3 0.0037 16.9 1.3 1.4 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DnaB_C PF03796.15 CCP38092.1 - 3.5e-76 255.9 1.8 4.8e-76 255.5 1.8 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DnaB PF00772.21 CCP38092.1 - 3.5e-10 39.9 0.6 1.4e-09 37.9 0.6 2.2 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain ATPase PF06745.13 CCP38092.1 - 1.8e-05 24.2 0.2 1.8e-05 24.2 0.2 2.8 2 2 0 2 2 2 1 KaiC Intein_splicing PF14890.6 CCP38092.1 - 0.00014 21.8 11.3 0.00014 21.8 11.3 2.3 2 0 0 2 2 2 1 Intein splicing domain AAA_25 PF13481.6 CCP38092.1 - 0.00015 21.4 0.0 0.00051 19.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain Rad51 PF08423.11 CCP38092.1 - 0.024 13.9 0.3 0.33 10.2 0.3 2.2 1 1 0 1 1 1 0 Rad51 AAA_2 PF07724.14 CCP38093.1 - 4.7e-57 192.8 0.0 1.8e-55 187.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Clp_N PF02861.20 CCP38093.1 - 4.6e-37 125.9 2.3 2.4e-17 62.8 0.2 2.9 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_lid_9 PF17871.1 CCP38093.1 - 1e-31 108.9 2.4 3.6e-31 107.2 2.4 2.0 1 0 0 1 1 1 1 AAA lid domain ClpB_D2-small PF10431.9 CCP38093.1 - 1.6e-24 85.8 1.5 4.1e-24 84.4 0.4 2.5 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CCP38093.1 - 2.8e-23 82.8 0.1 2.7e-12 47.2 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCP38093.1 - 6.7e-18 65.0 0.0 8.5e-12 45.3 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCP38093.1 - 1.7e-10 41.5 4.0 1.1e-05 25.9 0.2 4.7 4 1 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 CCP38093.1 - 3e-10 40.5 1.9 0.00067 20.0 0.0 5.1 2 2 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 CCP38093.1 - 8.9e-10 38.5 0.0 9.1e-05 22.2 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_18 PF13238.6 CCP38093.1 - 4.6e-07 30.4 0.4 0.069 13.7 0.0 3.6 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CCP38093.1 - 7e-07 29.1 0.0 0.01 15.6 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein TniB PF05621.11 CCP38093.1 - 1.1e-06 28.2 0.7 0.0037 16.7 0.0 4.0 3 1 1 4 4 4 1 Bacterial TniB protein AAA_14 PF13173.6 CCP38093.1 - 1.9e-05 24.7 0.0 0.18 11.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 CCP38093.1 - 7.3e-05 22.1 0.0 0.045 13.0 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin RNA_helicase PF00910.22 CCP38093.1 - 7.9e-05 23.0 0.0 0.76 10.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase RsgA_GTPase PF03193.16 CCP38093.1 - 8.8e-05 22.5 0.0 0.097 12.6 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase TsaE PF02367.17 CCP38093.1 - 0.0001 22.3 0.0 0.77 9.8 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE UVR PF02151.19 CCP38093.1 - 0.00013 21.6 7.0 0.00033 20.3 7.0 1.8 1 0 0 1 1 1 1 UvrB/uvrC motif NACHT PF05729.12 CCP38093.1 - 0.00013 21.9 0.1 0.048 13.6 0.0 3.2 2 1 0 2 2 2 1 NACHT domain RuvB_N PF05496.12 CCP38093.1 - 0.00016 21.5 0.5 3.6 7.3 0.0 4.3 4 0 0 4 4 4 2 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CCP38093.1 - 0.00017 21.9 0.1 0.65 10.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 CCP38093.1 - 0.00025 20.6 0.0 0.37 10.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 CCP38093.1 - 0.00037 19.9 0.7 1 8.7 0.0 3.9 3 1 0 4 4 3 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 CCP38093.1 - 0.00081 19.4 0.2 3 7.8 0.0 3.8 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 CCP38093.1 - 0.00085 19.2 0.0 0.73 9.7 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CCP38093.1 - 0.00088 19.4 0.1 3.7 7.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CCP38093.1 - 0.0017 18.0 0.2 0.077 12.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 CCP38093.1 - 0.0035 17.5 0.0 2.4 8.4 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 CCP38093.1 - 0.0049 16.8 8.9 0.21 11.5 0.1 4.5 4 1 0 5 5 5 1 ATPase domain predominantly from Archaea DNA_pol3_delta2 PF13177.6 CCP38093.1 - 0.0057 16.4 0.0 3 7.6 0.0 3.2 3 0 0 3 3 3 1 DNA polymerase III, delta subunit AAA_23 PF13476.6 CCP38093.1 - 0.0072 16.8 0.1 0.0072 16.8 0.1 3.5 2 1 0 2 2 1 1 AAA domain Torsin PF06309.11 CCP38093.1 - 0.0086 16.2 0.0 0.37 10.9 0.0 2.7 3 0 0 3 3 2 1 Torsin AAA_24 PF13479.6 CCP38093.1 - 0.014 15.2 0.2 1.6 8.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 CCP38093.1 - 0.064 13.2 2.1 10 6.0 0.0 3.7 4 0 0 4 4 3 0 NTPase CbiA PF01656.23 CCP38093.1 - 0.066 13.3 0.3 12 5.9 0.1 3.1 2 2 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 CCP38093.1 - 0.074 13.1 0.1 11 6.1 0.0 3.6 3 1 0 3 3 2 0 50S ribosome-binding GTPase Bac_DnaA PF00308.18 CCP38093.1 - 0.079 12.8 0.0 5 6.9 0.0 2.9 2 1 0 2 2 2 0 Bacterial dnaA protein T2SSE PF00437.20 CCP38093.1 - 0.081 12.0 3.7 0.061 12.4 0.2 2.7 3 1 0 3 3 3 0 Type II/IV secretion system protein AAA_29 PF13555.6 CCP38093.1 - 0.1 12.4 0.2 15 5.4 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CCP38093.1 - 0.1 13.1 0.3 22 5.5 0.0 3.3 3 0 0 3 3 3 0 ABC transporter AAA_19 PF13245.6 CCP38093.1 - 0.4 11.0 2.3 8.1 6.8 0.2 3.5 2 2 0 3 3 3 0 AAA domain TMEM37 PF15108.6 CCP38094.1 - 4.6e-05 23.4 0.5 5.6e-05 23.1 0.5 1.1 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family Ribosomal_L19 PF01245.20 CCP38095.1 - 1.5e-39 134.3 5.8 1.8e-39 134.1 5.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L19 TPP_enzyme_N PF02776.18 CCP38096.1 - 1.6e-52 177.6 0.0 3.8e-52 176.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CCP38096.1 - 4.1e-50 169.5 0.0 6.6e-49 165.6 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCP38096.1 - 1.6e-46 157.4 0.1 2.7e-46 156.7 0.1 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 CCP38096.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg DUF751 PF05421.11 CCP38097.1 - 3.5e-13 50.0 5.7 3.9e-13 49.9 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF751) DUF983 PF06170.12 CCP38097.1 - 0.072 13.5 1.3 0.087 13.2 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF983) AA_kinase PF00696.28 CCP38098.1 - 3e-47 161.3 1.8 3.4e-47 161.1 1.8 1.0 1 0 0 1 1 1 1 Amino acid kinase family Peptidase_M41 PF01434.18 CCP38099.1 - 1.4e-72 243.5 0.1 2.3e-72 242.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CCP38099.1 - 3.4e-47 160.2 0.0 3.9e-46 156.7 0.0 2.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCP38099.1 - 1.4e-12 47.2 0.1 3.6e-12 45.9 0.1 1.7 2 0 0 2 2 1 1 AAA+ lid domain FtsH_ext PF06480.15 CCP38099.1 - 1e-06 29.0 0.0 3.3e-05 24.2 0.0 2.6 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 CCP38099.1 - 5e-06 26.6 0.1 4.9e-05 23.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CCP38099.1 - 9.6e-05 21.7 1.4 0.00017 21.0 0.1 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 CCP38099.1 - 0.0001 22.1 0.0 0.00067 19.4 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCP38099.1 - 0.00016 22.1 0.2 0.0017 18.7 0.2 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 CCP38099.1 - 0.00028 21.0 0.0 0.00071 19.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CCP38099.1 - 0.00068 19.9 0.0 0.037 14.3 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 CCP38099.1 - 0.00087 19.7 0.5 0.0062 17.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCP38099.1 - 0.0019 17.9 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 CCP38099.1 - 0.002 18.7 0.3 0.037 14.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain ATPase PF06745.13 CCP38099.1 - 0.0027 17.1 0.6 1.1 8.5 0.0 3.0 3 0 0 3 3 3 1 KaiC Mg_chelatase PF01078.21 CCP38099.1 - 0.0068 15.8 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CCP38099.1 - 0.019 15.1 0.0 0.045 13.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCP38099.1 - 0.034 14.2 0.0 0.12 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCP38099.1 - 0.034 14.4 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCP38099.1 - 0.048 14.2 0.7 0.16 12.5 0.1 2.1 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 CCP38099.1 - 0.063 13.0 0.0 0.16 11.7 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 CCP38099.1 - 0.067 12.7 0.1 0.21 11.1 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 CCP38099.1 - 0.076 12.7 0.1 0.33 10.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain CHASE6_C PF17150.4 CCP38099.1 - 0.079 13.6 0.2 0.54 11.0 0.1 2.4 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain TsaE PF02367.17 CCP38099.1 - 0.16 12.0 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CCP38099.1 - 0.45 10.1 3.3 1.5 8.3 0.3 2.9 2 1 1 3 3 3 0 AAA domain PSI_PsaE PF02427.17 CCP38100.1 - 4.1e-26 90.4 1.9 4.4e-26 90.3 1.9 1.0 1 0 0 1 1 1 1 Photosystem I reaction centre subunit IV / PsaE PsbH PF00737.20 CCP38101.1 - 1.6e-32 111.0 0.8 1.8e-32 110.8 0.8 1.1 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein Ac81 PF05820.11 CCP38101.1 - 0.018 14.6 1.2 0.021 14.4 1.2 1.0 1 0 0 1 1 1 0 Baculoviridae AC81 PsbN PF02468.15 CCP38102.1 - 1.9e-23 82.0 0.1 2e-23 81.9 0.1 1.0 1 0 0 1 1 1 1 Photosystem II reaction centre N protein (psbN) PsbT PF01405.17 CCP38103.1 - 1.7e-18 66.1 6.2 1.8e-18 66.0 6.2 1.0 1 0 0 1 1 1 1 Photosystem II reaction centre T protein YlaH PF14036.6 CCP38103.1 - 0.0071 16.6 0.8 0.0071 16.6 0.8 1.0 1 0 0 1 1 1 1 YlaH-like protein SafA PF17073.5 CCP38103.1 - 0.079 12.9 0.2 0.079 12.9 0.2 1.1 1 0 0 1 1 1 0 Two-component-system connector protein PSII PF00421.19 CCP38104.1 - 2.8e-258 857.7 6.5 3.1e-258 857.5 6.5 1.0 1 0 0 1 1 1 1 Photosystem II protein ABC2_membrane PF01061.24 CCP38105.1 - 4.8e-27 94.8 29.7 4.8e-27 94.8 29.7 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCP38105.1 - 0.0012 18.0 43.3 0.0012 18.0 43.3 1.6 1 1 1 2 2 2 1 ABC-2 family transporter protein Fer2 PF00111.27 CCP38106.1 - 6.4e-20 70.9 0.2 7.8e-20 70.6 0.2 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF1397 PF07165.11 CCP38106.1 - 0.039 13.4 0.1 0.049 13.0 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1397) Ribosomal_S10 PF00338.22 CCP38107.1 - 1.7e-36 124.4 0.2 1.9e-36 124.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e GTP_EFTU PF00009.27 CCP38108.1 - 1.6e-58 197.4 0.4 2.2e-58 197.0 0.4 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCP38108.1 - 1.6e-34 118.6 1.5 1.6e-34 118.6 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCP38108.1 - 1.5e-19 70.1 5.8 3.5e-19 69.0 5.8 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCP38108.1 - 3.9e-05 23.7 0.1 0.00012 22.2 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CCP38108.1 - 0.025 14.2 0.3 0.056 13.0 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ribosomal_S7 PF00177.21 CCP38109.1 - 1.2e-58 197.0 1.5 1.3e-58 196.9 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Acetyltransf_CG PF14542.6 CCP38109.1 - 0.039 14.1 0.0 9.1 6.5 0.0 2.5 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Ribosom_S12_S23 PF00164.25 CCP38110.1 - 8.4e-44 147.8 1.9 9.8e-44 147.6 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 CCP38110.1 - 0.15 12.8 0.0 0.22 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S12 Ribosomal_L31 PF01197.18 CCP38111.1 - 5.6e-24 84.2 0.1 6.7e-24 83.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L31 Ribosomal_S9 PF00380.19 CCP38112.1 - 2.4e-42 144.3 0.1 2.8e-42 144.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13 PF00572.18 CCP38113.1 - 2.2e-46 157.2 0.1 2.5e-46 157.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 Cag12 PF13117.6 CCP38113.1 - 0.0016 18.9 1.3 1.3 9.6 0.3 2.4 1 1 1 2 2 2 2 Cag pathogenicity island protein Cag12 RNA_pol_A_CTD PF03118.15 CCP38114.1 - 2.2e-25 88.2 2.3 3.8e-25 87.4 2.3 1.4 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain RNA_pol_L PF01193.24 CCP38114.1 - 1.6e-17 62.6 0.0 4e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 CCP38114.1 - 3.7e-17 62.7 0.1 7.6e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain HHH_5 PF14520.6 CCP38114.1 - 1.3e-05 25.7 0.0 3.9e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 CCP38114.1 - 0.0017 18.4 0.6 0.0041 17.2 0.1 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HRDC PF00570.23 CCP38114.1 - 0.0068 16.4 0.0 2.1 8.4 0.0 2.6 3 0 0 3 3 3 2 HRDC domain WSN PF02206.18 CCP38114.1 - 0.041 13.8 0.4 3.9 7.5 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function Ribosomal_S11 PF00411.19 CCP38115.1 - 2.9e-48 162.8 1.5 3.5e-48 162.6 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 MCPVI PF02993.14 CCP38115.1 - 0.033 14.0 0.2 0.041 13.7 0.2 1.2 1 0 0 1 1 1 0 Minor capsid protein VI LPD7 PF18821.1 CCP38115.1 - 0.038 14.1 0.1 0.053 13.6 0.1 1.4 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 7 Ribosomal_L18p PF00861.22 CCP38115.1 - 0.054 13.9 0.4 0.073 13.4 0.4 1.3 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast YdjC PF04794.12 CCP38115.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 YdjC-like protein Ribosomal_S13 PF00416.22 CCP38116.1 - 3.1e-29 101.9 7.5 9.2e-28 97.2 7.5 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Ribosomal_L36 PF00444.18 CCP38117.1 - 3e-19 68.9 14.1 3.2e-19 68.8 14.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36 SecY PF00344.20 CCP38118.1 - 2.4e-93 312.8 29.1 3e-93 312.5 29.1 1.1 1 0 0 1 1 1 1 SecY translocase Ribosomal_S5 PF00333.20 CCP38119.1 - 1.9e-23 82.2 5.4 1.9e-23 82.2 5.4 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CCP38119.1 - 3.2e-23 81.0 1.1 4.6e-23 80.4 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_L18p PF00861.22 CCP38120.1 - 8.8e-39 132.5 0.4 9.7e-39 132.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Mur_ligase PF01225.25 CCP38120.1 - 0.017 15.4 0.3 0.064 13.6 0.0 1.9 1 1 1 2 2 2 0 Mur ligase family, catalytic domain Ribosomal_L6 PF00347.23 CCP38121.1 - 3.1e-35 120.7 4.3 7.2e-20 71.5 1.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF5108 PF17133.4 CCP38121.1 - 0.076 13.0 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5108) Ribosomal_S8 PF00410.19 CCP38122.1 - 6.1e-51 171.7 0.1 6.8e-51 171.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L5_C PF00673.21 CCP38123.1 - 1.2e-38 131.1 0.1 2.2e-38 130.3 0.1 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CCP38123.1 - 9.3e-24 83.5 1.2 1.2e-23 83.2 0.3 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 ribosomal_L24 PF17136.4 CCP38124.1 - 8.9e-17 61.3 1.9 8.9e-17 61.3 1.9 2.0 2 1 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 CCP38124.1 - 1.6e-06 27.8 6.8 6e-06 26.0 4.4 2.3 2 0 0 2 2 2 1 KOW motif SH3_2 PF07653.17 CCP38124.1 - 0.037 13.7 0.6 0.13 12.0 0.6 1.9 1 1 0 1 1 1 0 Variant SH3 domain Ribosomal_L14 PF00238.19 CCP38125.1 - 7.7e-53 177.8 1.1 8.5e-53 177.6 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.20 CCP38126.1 - 2.3e-29 101.3 8.4 2.7e-29 101.1 8.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S17 Mucin_bdg PF03272.13 CCP38126.1 - 0.049 13.7 1.6 0.53 10.3 0.4 1.9 1 1 1 2 2 2 0 Putative mucin or carbohydrate-binding module Ribosomal_L29 PF00831.23 CCP38127.1 - 7.7e-11 41.8 6.5 8.6e-11 41.7 6.5 1.0 1 0 0 1 1 1 1 Ribosomal L29 protein Ribosomal_L16 PF00252.18 CCP38128.1 - 4.3e-51 172.4 0.6 4.8e-51 172.2 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_S3_C PF00189.20 CCP38129.1 - 2.5e-36 124.1 2.2 5.7e-36 122.9 1.4 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CCP38129.1 - 3.4e-15 55.6 1.2 3.4e-15 55.6 1.2 1.9 2 0 0 2 2 2 1 KH domain DNA_pol3_a_NI PF14480.6 CCP38129.1 - 0.031 14.2 0.2 1 9.4 0.0 2.5 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus I KH_4 PF13083.6 CCP38129.1 - 0.038 13.8 0.6 0.11 12.4 0.6 1.9 1 1 0 1 1 1 0 KH domain Ribosomal_L22 PF00237.19 CCP38130.1 - 3.5e-28 97.9 0.0 3.9e-28 97.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S19 PF00203.21 CCP38131.1 - 1.4e-32 111.4 0.5 1.5e-32 111.3 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L2_C PF03947.18 CCP38132.1 - 1.3e-56 190.3 0.5 2.8e-56 189.1 0.5 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCP38132.1 - 1.8e-33 114.3 1.5 3.6e-33 113.4 1.5 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L23 PF00276.20 CCP38133.1 - 5.3e-30 103.6 3.9 6.1e-30 103.4 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L23 Ribosomal_L4 PF00573.22 CCP38134.1 - 1.1e-59 201.4 1.7 1.3e-59 201.1 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DHHA1 PF02272.19 CCP38134.1 - 0.02 15.3 1.3 0.041 14.3 1.3 1.5 1 0 0 1 1 1 0 DHHA1 domain Ribosomal_L3 PF00297.22 CCP38135.1 - 9.3e-16 57.8 2.0 5.2e-15 55.3 0.4 2.3 1 1 1 2 2 2 2 Ribosomal protein L3 HSP70 PF00012.20 CCP38136.1 - 1.1e-257 856.1 16.3 1.3e-257 855.9 16.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCP38136.1 - 4.1e-20 71.9 6.0 3.8e-17 62.1 0.1 3.0 3 1 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 CCP38136.1 - 0.00032 21.1 6.7 0.0088 16.5 0.2 3.4 3 2 0 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.20 CCP38136.1 - 0.0015 18.1 0.1 1.7 8.1 0.0 2.8 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.16 CCP38136.1 - 0.0017 18.1 0.3 0.0048 16.6 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Raco_middle PF17651.1 CCP38136.1 - 0.4 10.4 2.7 2.4 7.8 0.0 3.0 3 0 0 3 3 3 0 RACo middle region Ycf9 PF01737.17 CCP38137.1 - 4.6e-22 77.7 5.9 5.3e-22 77.5 5.9 1.0 1 0 0 1 1 1 1 YCF9 PsbK PF02533.15 CCP38138.1 - 1.7e-25 88.9 6.4 1.9e-25 88.7 6.4 1.0 1 0 0 1 1 1 1 Photosystem II 4 kDa reaction centre component PetG PF02529.15 CCP38139.1 - 3.8e-24 84.2 1.6 4.1e-24 84.1 1.6 1.0 1 0 0 1 1 1 1 Cytochrome B6-F complex subunit 5 PGF-CTERM PF18204.1 CCP38139.1 - 0.045 13.7 0.9 0.045 13.7 0.9 2.0 2 0 0 2 2 2 0 PGF-CTERM motif DUF3852 PF12963.7 CCP38139.1 - 0.065 13.6 0.0 0.065 13.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) Ribosomal_S14 PF00253.21 CCP38140.1 - 8.4e-24 83.1 1.3 8.4e-24 83.1 1.3 1.5 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e PsaA_PsaB PF00223.19 CCP38141.1 - 0 1165.0 40.0 0 1164.8 40.0 1.0 1 0 0 1 1 1 1 Photosystem I psaA/psaB protein PsaA_PsaB PF00223.19 CCP38142.1 - 0 1274.2 40.3 0 1274.0 40.3 1.0 1 0 0 1 1 1 1 Photosystem I psaA/psaB protein Biotin_lipoyl PF00364.22 CCP38143.1 - 1.3e-18 66.6 0.6 2.1e-18 65.9 0.6 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCP38143.1 - 5.8e-05 22.8 0.2 0.00016 21.4 0.2 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like GCV_H PF01597.19 CCP38143.1 - 0.0097 15.8 1.3 0.018 15.0 0.1 1.9 2 0 0 2 2 2 1 Glycine cleavage H-protein HlyD_3 PF13437.6 CCP38143.1 - 0.02 15.6 0.8 0.18 12.5 0.1 2.2 2 0 0 2 2 2 0 HlyD family secretion protein DUF4388 PF14332.6 CCP38143.1 - 0.045 14.0 0.0 0.82 10.0 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4388) UPF0231 PF06062.11 CCP38143.1 - 0.19 12.0 4.2 0.075 13.3 1.2 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0231) DUF5376 PF17346.2 CCP38143.1 - 0.71 10.2 5.8 0.15 12.4 1.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5376) DUF2862 PF11061.8 CCP38144.1 - 4.4e-06 26.4 0.6 5.2e-06 26.2 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2862) AAA PF00004.29 CCP38145.1 - 6.3e-07 29.9 0.0 1.4e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CCP38145.1 - 2e-06 27.7 0.3 4.1e-06 26.6 0.1 1.6 2 0 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 CCP38145.1 - 7.1e-06 26.0 5.5 0.064 13.2 0.0 3.5 2 1 0 3 3 3 2 NTPase AAA_5 PF07728.14 CCP38145.1 - 2.3e-05 24.4 1.0 0.00044 20.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCP38145.1 - 2.8e-05 23.9 0.0 6.1e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCP38145.1 - 5.3e-05 23.8 0.0 0.00028 21.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain R3H PF01424.22 CCP38145.1 - 7.3e-05 22.7 0.0 0.00019 21.4 0.0 1.7 1 0 0 1 1 1 1 R3H domain AAA_22 PF13401.6 CCP38145.1 - 9.6e-05 22.7 0.3 0.00047 20.4 0.1 2.3 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 CCP38145.1 - 0.00055 20.4 0.1 0.0014 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain TsaE PF02367.17 CCP38145.1 - 0.0011 18.9 0.2 0.36 10.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 CCP38145.1 - 0.0014 18.8 0.2 0.0057 16.8 0.0 2.1 2 0 0 2 2 2 1 Helicase HerA, central domain CbiA PF01656.23 CCP38145.1 - 0.0017 18.4 0.0 0.0041 17.2 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CCP38145.1 - 0.0017 18.3 0.0 0.0067 16.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CCP38145.1 - 0.0019 18.4 0.8 0.062 13.4 0.1 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 CCP38145.1 - 0.0035 17.3 0.0 0.027 14.4 0.0 2.3 2 0 0 2 2 2 1 NACHT domain TrwB_AAD_bind PF10412.9 CCP38145.1 - 0.0062 15.5 0.2 0.013 14.4 0.1 1.6 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 CCP38145.1 - 0.0063 16.0 0.0 0.019 14.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 CCP38145.1 - 0.0076 16.6 0.9 0.021 15.1 0.0 2.1 3 0 0 3 3 1 1 AAA domain SRP54 PF00448.22 CCP38145.1 - 0.0094 15.6 0.1 0.028 14.1 0.0 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 CCP38145.1 - 0.012 14.7 0.7 0.026 13.6 0.7 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 CCP38145.1 - 0.012 15.2 1.8 0.15 11.6 0.1 3.1 2 1 2 4 4 4 0 AAA domain RuvB_N PF05496.12 CCP38145.1 - 0.012 15.3 0.0 0.036 13.8 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 CCP38145.1 - 0.016 15.0 0.7 0.049 13.4 0.0 2.1 2 1 1 3 3 3 0 AAA domain Rad17 PF03215.15 CCP38145.1 - 0.018 15.0 1.8 0.062 13.2 0.0 2.6 3 1 1 4 4 3 0 Rad17 P-loop domain IstB_IS21 PF01695.17 CCP38145.1 - 0.02 14.6 0.1 1.7 8.3 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.22 CCP38145.1 - 0.021 15.2 0.0 0.11 12.9 0.0 2.3 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 CCP38145.1 - 0.024 14.9 0.0 0.049 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCP38145.1 - 0.03 14.5 0.0 0.26 11.4 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_3 PF07726.11 CCP38145.1 - 0.032 14.1 0.1 0.21 11.5 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CCP38145.1 - 0.032 13.6 2.2 0.14 11.6 0.5 2.7 2 1 0 2 2 2 0 Bacterial TniB protein Viral_helicase1 PF01443.18 CCP38145.1 - 0.033 13.9 0.0 0.092 12.5 0.0 1.8 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 CCP38145.1 - 0.039 12.9 0.0 0.069 12.1 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Mg_chelatase PF01078.21 CCP38145.1 - 0.047 13.1 0.2 0.1 11.9 0.0 1.7 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI DnaB_C PF03796.15 CCP38145.1 - 0.063 12.6 1.8 0.66 9.3 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain ENTH PF01417.20 CCP38145.1 - 0.064 13.3 2.0 0.17 12.0 2.0 1.7 1 0 0 1 1 1 0 ENTH domain ParA PF10609.9 CCP38145.1 - 0.092 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase ABC_tran PF00005.27 CCP38145.1 - 0.095 13.2 0.0 0.095 13.2 0.0 2.3 2 1 0 2 2 2 0 ABC transporter PP-binding PF00550.25 CCP38146.1 - 1.1e-16 60.9 0.9 1.3e-16 60.7 0.9 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CCP38146.1 - 0.0004 20.5 1.5 0.00061 20.0 1.4 1.5 1 1 0 1 1 1 1 Acyl-carrier Ribosomal_L50 PF10501.9 CCP38146.1 - 0.013 15.6 0.1 0.016 15.3 0.1 1.4 1 1 0 1 1 1 0 Ribosomal subunit 39S Ribosomal_L12_N PF16320.5 CCP38146.1 - 0.12 12.1 1.6 0.17 11.6 0.1 2.0 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain DUF1493 PF07377.12 CCP38146.1 - 0.13 12.7 0.5 0.14 12.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) PsaD PF02531.16 CCP38147.1 - 9.5e-69 229.2 0.1 1.1e-68 229.0 0.1 1.0 1 0 0 1 1 1 1 PsaD Rubrerythrin PF02915.17 CCP38148.1 - 2.9e-43 147.6 0.0 6.3e-43 146.5 0.0 1.6 1 0 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.6 CCP38148.1 - 0.021 15.0 0.0 0.88 9.8 0.0 2.4 2 0 0 2 2 2 0 Ferritin-like domain rve_3 PF13683.6 CCP38148.1 - 0.051 13.4 0.1 0.17 11.7 0.1 1.9 1 0 0 1 1 1 0 Integrase core domain RGCC PF15151.6 CCP38148.1 - 0.11 12.8 0.2 0.19 12.0 0.2 1.3 1 0 0 1 1 1 0 Response gene to complement 32 protein family DUF4812 PF16071.5 CCP38148.1 - 0.13 12.1 0.7 0.34 10.8 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4812) PetN PF03742.14 CCP38149.1 - 4.3e-17 61.7 5.6 4.6e-17 61.6 5.6 1.0 1 0 0 1 1 1 1 PetN DUF1358 PF07096.11 CCP38149.1 - 0.15 12.1 0.8 0.13 12.2 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1358) PetM PF08041.11 CCP38150.1 - 1.1e-11 44.1 1.3 1.2e-11 44.0 1.3 1.0 1 0 0 1 1 1 1 PetM family of cytochrome b6f complex subunit 7 SK_channel PF03530.14 CCP38150.1 - 0.052 13.5 0.6 0.053 13.5 0.6 1.0 1 0 0 1 1 1 0 Calcium-activated SK potassium channel SecG PF03840.14 CCP38151.1 - 1.4e-06 28.3 3.7 1.5e-06 28.1 3.7 1.1 1 0 0 1 1 1 1 Preprotein translocase SecG subunit DUF1230 PF06799.11 CCP38152.1 - 4.5e-44 150.0 0.2 5.3e-44 149.8 0.2 1.0 1 0 0 1 1 1 1 Conserved in the green lineage and diatoms 27 Vma12 PF11712.8 CCP38152.1 - 1.7 8.7 3.7 7.3 6.7 0.1 2.2 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase AhpC-TSA PF00578.21 CCP38153.1 - 1.8e-38 131.3 0.0 2.3e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCP38153.1 - 9.9e-14 51.3 0.0 1.3e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCP38153.1 - 5.8e-08 32.5 0.0 9.7e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 CCP38153.1 - 0.018 15.0 0.0 0.044 13.7 0.0 1.6 2 0 0 2 2 2 0 SCO1/SenC DUF2840 PF11000.8 CCP38153.1 - 0.085 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) Heme_oxygenase PF01126.20 CCP38154.1 - 5e-82 274.7 0.6 5.7e-82 274.5 0.6 1.0 1 0 0 1 1 1 1 Heme oxygenase Ribosomal_L35p PF01632.19 CCP38155.1 - 1.1e-14 54.6 14.9 1.2e-14 54.6 14.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L35 Ribosomal_L20 PF00453.18 CCP38156.1 - 2.4e-44 149.8 2.7 2.7e-44 149.7 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L20 polyprenyl_synt PF00348.17 CCP38157.1 - 1.7e-71 240.3 0.0 2.1e-71 240.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 CCP38157.1 - 0.0048 16.5 0.2 0.0078 15.8 0.2 1.3 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 DUF3272 PF11676.8 CCP38157.1 - 0.033 14.4 0.2 0.1 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3272) E1_dh PF00676.20 CCP38158.1 - 7.1e-80 268.1 0.0 8.1e-80 268.0 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CCP38158.1 - 1.3e-08 34.8 0.1 5.5e-08 32.7 0.1 1.9 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CCP38158.1 - 0.097 11.9 0.0 0.22 10.7 0.0 1.4 1 1 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CCP38159.1 - 3.8e-48 163.5 0.0 7.7e-48 162.5 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCP38159.1 - 1.8e-36 124.7 0.2 4.2e-36 123.5 0.2 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain AAA_26 PF13500.6 CCP38159.1 - 0.003 17.4 0.1 0.0056 16.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain Apocytochr_F_N PF16639.5 CCP38160.1 - 5.3e-77 257.4 0.2 7.6e-77 256.9 0.2 1.2 1 0 0 1 1 1 1 Apocytochrome F, N-terminal Apocytochr_F_C PF01333.19 CCP38160.1 - 7.8e-43 145.3 0.8 1.2e-42 144.7 0.8 1.3 1 0 0 1 1 1 1 Apocytochrome F, C-terminal TatC PF00902.18 CCP38161.1 - 5.7e-55 186.3 21.9 6.9e-55 186.1 21.9 1.1 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) PBS_linker_poly PF00427.21 CCP38162.1 - 6e-119 391.5 13.2 2.1e-42 144.1 0.2 3.3 3 0 0 3 3 3 3 Phycobilisome Linker polypeptide Phycobilisome PF00502.19 CCP38162.1 - 7.1e-23 81.3 0.1 1.1e-12 48.2 0.0 2.6 2 0 0 2 2 2 2 Phycobilisome protein KorB PF08535.10 CCP38162.1 - 0.0013 18.7 0.4 5.6 7.1 0.0 3.5 3 0 0 3 3 3 2 KorB domain Ribosomal_L23 PF00276.20 CCP38162.1 - 0.012 16.0 0.2 0.039 14.3 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L23 DUF1878 PF08963.10 CCP38162.1 - 1.2 9.7 5.8 23 5.5 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1878) Phycobilisome PF00502.19 CCP38163.1 - 2e-56 190.2 0.0 2.2e-56 190.1 0.0 1.0 1 0 0 1 1 1 1 Phycobilisome protein Phycobilisome PF00502.19 CCP38164.1 - 1.1e-58 197.5 0.2 1.3e-58 197.4 0.2 1.0 1 0 0 1 1 1 1 Phycobilisome protein ATP-synt_DE_N PF02823.16 CCP38165.1 - 2.1e-25 88.4 0.0 3.1e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_DE PF00401.20 CCP38165.1 - 1.6e-09 37.8 7.5 2.6e-09 37.2 7.5 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain ATP-synt_ab PF00006.25 CCP38166.1 - 8.5e-64 215.1 0.0 1.2e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCP38166.1 - 4.3e-22 78.4 0.4 9.5e-22 77.3 0.4 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CCP38166.1 - 0.00017 21.0 0.3 0.0027 17.1 0.1 2.2 2 0 0 2 2 2 1 KaiC AAA PF00004.29 CCP38166.1 - 0.00019 21.9 0.1 0.0049 17.3 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CCP38166.1 - 0.00054 19.9 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea T3SS_ATPase_C PF18269.1 CCP38166.1 - 0.0025 17.6 0.1 0.026 14.4 0.1 2.2 2 0 0 2 2 2 1 T3SS EscN ATPase C-terminal domain RsgA_GTPase PF03193.16 CCP38166.1 - 0.0089 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 CCP38166.1 - 0.042 14.4 0.0 0.091 13.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CCP38166.1 - 0.052 13.9 0.1 0.14 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 CCP38166.1 - 0.097 13.1 0.0 0.26 11.7 0.0 1.7 2 0 0 2 2 2 0 RNA helicase DUF2075 PF09848.9 CCP38166.1 - 0.16 11.2 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CCP38166.1 - 0.19 12.0 1.6 0.44 10.9 0.5 2.0 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 CCP38166.1 - 0.22 10.4 0.1 0.47 9.3 0.1 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NB-ARC PF00931.22 CCP38166.1 - 0.36 10.0 0.7 0.62 9.2 0.3 1.5 2 0 0 2 2 2 0 NB-ARC domain TPR_1 PF00515.28 CCP38167.1 - 2.3e-19 68.3 18.5 2e-08 33.7 2.3 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCP38167.1 - 2.1e-13 49.3 14.4 9.6e-07 28.5 1.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCP38167.1 - 1.6e-10 41.1 16.4 4.2e-06 27.0 6.1 4.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCP38167.1 - 1.1e-09 37.6 8.8 0.00053 19.8 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCP38167.1 - 1.3e-08 34.4 15.7 7.7e-05 22.6 1.4 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCP38167.1 - 1.8e-07 30.7 22.1 6.5e-06 25.7 5.1 3.6 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.6 CCP38167.1 - 6.4e-06 26.5 6.2 0.065 13.9 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCP38167.1 - 4.7e-05 23.9 5.0 0.00043 20.9 1.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCP38167.1 - 5.8e-05 22.8 16.1 0.0012 18.6 0.6 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCP38167.1 - 0.00056 20.1 9.4 0.16 12.4 0.0 4.0 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCP38167.1 - 0.0011 19.7 1.3 0.16 12.9 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TOM20_plant PF06552.12 CCP38167.1 - 0.012 15.4 0.5 0.02 14.6 0.5 1.4 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 MIT PF04212.18 CCP38167.1 - 0.043 13.9 13.0 0.33 11.1 2.5 3.4 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain HemY_N PF07219.13 CCP38167.1 - 0.088 13.0 0.9 6 7.1 0.0 2.8 1 1 1 2 2 2 0 HemY protein N-terminus TPR_19 PF14559.6 CCP38167.1 - 0.3 11.6 6.9 8 7.1 0.3 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF2225 PF09986.9 CCP38167.1 - 0.33 10.6 7.6 0.14 11.8 1.5 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) GTP_EFTU PF00009.27 CCP38168.1 - 6.2e-31 107.5 3.4 1.8e-29 102.7 3.4 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCP38168.1 - 1.3e-26 92.7 1.4 1.3e-26 92.7 1.4 3.4 3 0 0 3 3 3 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 CCP38168.1 - 3.8e-10 39.9 0.1 2.2e-09 37.4 0.1 2.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 CCP38168.1 - 1.9e-08 34.0 0.5 5.6e-07 29.3 0.0 2.9 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU_D2 PF03144.25 CCP38168.1 - 1.2e-06 28.8 0.4 0.0013 19.1 0.0 2.8 2 0 0 2 2 2 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 CCP38168.1 - 0.00076 19.3 2.3 0.48 10.4 0.1 2.8 2 0 0 2 2 2 2 Elongation factor Tu domain 4 Roc PF08477.13 CCP38168.1 - 0.0016 18.6 1.1 0.0044 17.2 0.1 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CCP38168.1 - 0.027 13.4 0.2 0.082 11.9 0.2 1.8 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Phage-A118_gp45 PF10653.9 CCP38168.1 - 0.13 12.3 0.8 0.66 10.0 0.1 2.6 2 0 0 2 2 2 0 Protein gp45 of Bacteriophage A118 AAA_23 PF13476.6 CCP38168.1 - 5.7 7.4 30.6 7.6 7.0 7.0 3.8 2 1 0 2 2 2 0 AAA domain Ribosomal_S18 PF01084.20 CCP38169.1 - 3.3e-23 81.7 1.0 3.9e-23 81.4 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S18 Ribosomal_L33 PF00471.20 CCP38170.1 - 1.9e-19 69.8 5.7 2.3e-19 69.6 5.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L33 WCCH PF03716.14 CCP38170.1 - 0.42 10.3 3.3 0.82 9.4 3.3 1.5 1 0 0 1 1 1 0 WCCH motif Ribosomal_S20p PF01649.18 CCP38171.1 - 2.2e-18 66.7 8.2 2.4e-18 66.5 8.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S20 Glycoprot_B_PH2 PF17417.2 CCP38171.1 - 0.031 14.6 0.3 0.036 14.4 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B PH-like domain AROS PF15684.5 CCP38171.1 - 0.042 14.4 3.1 0.044 14.4 3.1 1.1 1 0 0 1 1 1 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 RNA_pol_Rpb2_6 PF00562.28 CCP38172.1 - 2.1e-153 511.0 0.0 1.5e-152 508.2 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_2 PF04561.14 CCP38172.1 - 2.3e-49 167.6 2.2 4.9e-49 166.6 2.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 CCP38172.1 - 1.6e-30 105.0 0.0 3.1e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 CCP38172.1 - 8.2e-25 87.0 0.0 2.7e-24 85.4 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.15 CCP38172.1 - 8.1e-16 58.1 0.0 3e-15 56.3 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_45 PF10385.9 CCP38172.1 - 6.9e-14 51.9 0.2 1.1e-12 48.0 0.1 2.9 3 0 0 3 3 3 1 RNA polymerase beta subunit external 1 domain RNA_pol_Rpb1_1 PF04997.12 CCP38173.1 - 3.1e-75 253.4 0.0 5.8e-75 252.5 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CCP38173.1 - 6.5e-40 137.1 0.0 2.1e-27 96.4 0.0 2.5 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCP38173.1 - 5.4e-12 45.9 0.0 1.2e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 Cas9-BH PF16593.5 CCP38173.1 - 0.54 10.0 2.5 0.56 10.0 0.6 2.0 2 0 0 2 2 2 0 Bridge helix of CRISPR-associated endonuclease Cas9 RNA_pol_Rpb1_5 PF04998.17 CCP38174.1 - 2.3e-53 181.4 13.6 7.4e-44 150.2 7.2 3.2 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.17 CCP38174.1 - 1.2e-16 60.6 0.1 4.1e-16 58.9 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 CCP38174.1 - 3.1e-07 30.5 2.3 8.8e-07 29.0 0.1 2.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 Peptidase_M23 PF01551.22 CCP38174.1 - 9.1e-06 25.8 5.1 0.013 15.6 0.0 4.8 5 1 1 6 6 6 2 Peptidase family M23 DUF5126 PF17166.4 CCP38174.1 - 0.0069 16.2 0.5 0.25 11.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5126) RnfC_N PF13375.6 CCP38174.1 - 0.082 12.9 2.8 4 7.4 0.0 4.6 5 0 0 5 5 5 0 RnfC Barrel sandwich hybrid domain TubC_N PF18563.1 CCP38174.1 - 0.094 12.7 0.0 0.56 10.2 0.0 2.4 2 0 0 2 2 2 0 TubC N-terminal docking domain Ribosomal_S2 PF00318.20 CCP38175.1 - 3.3e-92 307.6 0.1 3.8e-92 307.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S2 EF_TS PF00889.19 CCP38176.1 - 5.2e-31 107.9 7.2 4.6e-30 104.8 7.2 2.3 1 1 0 1 1 1 1 Elongation factor TS HOIP-UBA PF16678.5 CCP38176.1 - 0.048 13.7 0.1 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 HOIP UBA domain pair CART PF06373.11 CCP38176.1 - 0.12 12.6 0.0 0.36 11.0 0.0 1.8 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) ATP-synt_A PF00119.20 CCP38177.1 - 1.6e-53 181.8 8.3 2e-53 181.5 8.3 1.0 1 0 0 1 1 1 1 ATP synthase A chain ATP-synt_C PF00137.21 CCP38178.1 - 1.2e-19 70.4 7.5 1.5e-19 70.0 7.5 1.1 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_B PF00430.18 CCP38179.1 - 3.3e-26 91.9 12.4 3.9e-26 91.7 12.4 1.1 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Phasin PF05597.11 CCP38179.1 - 0.0056 16.7 9.6 0.0075 16.3 9.6 1.1 1 0 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) FmrO PF07091.11 CCP38179.1 - 0.053 13.1 0.3 0.071 12.7 0.3 1.1 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Exonuc_VII_L PF02601.15 CCP38179.1 - 0.11 12.0 5.7 0.12 12.0 5.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Acetyltransf_18 PF18014.1 CCP38179.1 - 0.14 12.0 2.5 0.26 11.1 1.3 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PIN_8 PF18476.1 CCP38179.1 - 0.17 11.7 9.2 0.23 11.3 9.2 1.1 1 0 0 1 1 1 0 PIN like domain AAA_23 PF13476.6 CCP38179.1 - 0.56 10.7 10.4 0.65 10.5 10.4 1.2 1 0 0 1 1 1 0 AAA domain V-ATPase_G_2 PF16999.5 CCP38179.1 - 0.61 10.5 14.3 2.6 8.5 2.3 2.2 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit YbjQ_1 PF01906.17 CCP38179.1 - 0.88 10.2 3.2 0.88 10.2 1.1 1.9 1 1 1 2 2 2 0 Putative heavy-metal-binding DUF2937 PF11157.8 CCP38179.1 - 0.98 9.1 6.2 1.6 8.4 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) PCRF PF03462.18 CCP38179.1 - 1.4 8.8 9.4 1.8 8.4 9.4 1.2 1 0 0 1 1 1 0 PCRF domain DivIVA PF05103.13 CCP38179.1 - 1.5 8.9 16.2 3 7.9 16.2 1.6 1 1 0 1 1 1 0 DivIVA protein ATP-synt_B PF00430.18 CCP38180.1 - 2.3e-17 63.3 18.5 2.7e-17 63.1 18.5 1.1 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) FmdA_AmdA PF03069.15 CCP38180.1 - 0.037 12.9 0.0 0.046 12.6 0.0 1.1 1 0 0 1 1 1 0 Acetamidase/Formamidase family Peptidase_S46 PF10459.9 CCP38180.1 - 0.12 11.0 2.2 0.14 10.8 2.2 1.0 1 0 0 1 1 1 0 Peptidase S46 GPW_gp25 PF04965.14 CCP38180.1 - 0.13 12.0 6.0 0.17 11.7 2.1 2.2 1 1 1 2 2 2 0 Gene 25-like lysozyme KxDL PF10241.9 CCP38180.1 - 4.2 7.7 11.7 0.2 11.9 5.4 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein OSCP PF00213.18 CCP38181.1 - 1.1e-39 136.3 5.6 1.2e-39 136.2 5.6 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit ATP-synt_ab PF00006.25 CCP38182.1 - 7.5e-76 254.5 0.2 2.1e-75 253.0 0.2 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CCP38182.1 - 7.6e-46 155.5 3.3 1.3e-45 154.7 3.3 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CCP38182.1 - 8.8e-18 64.6 2.8 2.1e-17 63.4 2.8 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CCP38182.1 - 8.3e-05 22.0 1.2 0.00021 20.7 0.2 2.0 2 0 0 2 2 2 1 KaiC HAS-barrel PF09378.10 CCP38182.1 - 0.00015 21.9 0.3 0.00053 20.1 0.3 2.0 1 0 0 1 1 1 1 HAS barrel domain ATPase_2 PF01637.18 CCP38182.1 - 0.075 12.9 0.5 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CCP38183.1 - 3.1e-21 76.3 0.0 4.1e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCP38183.1 - 9.3e-06 25.2 4.5 0.00057 19.4 4.5 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCP38183.1 - 5.6e-05 23.1 1.0 0.21 11.4 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CCP38183.1 - 0.0042 16.8 2.2 0.012 15.4 2.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCP38183.1 - 0.0065 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_10 PF12846.7 CCP38183.1 - 0.017 14.1 0.1 0.024 13.6 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.6 CCP38183.1 - 0.019 14.7 0.1 0.046 13.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 CCP38183.1 - 0.021 15.2 0.1 0.23 11.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 CCP38183.1 - 0.047 14.2 1.6 0.091 13.3 0.3 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCP38183.1 - 0.097 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 CCP38183.1 - 0.15 12.3 0.8 1.4 9.2 0.8 2.1 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CCP38183.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain UPF0051 PF01458.17 CCP38184.1 - 1.6e-61 207.8 0.2 2.2e-61 207.4 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) CbiQ PF02361.16 CCP38185.1 - 0.3 10.7 21.2 1.3 8.6 21.2 2.5 1 1 0 1 1 1 0 Cobalt transport protein NmrA PF05368.13 CCP38186.1 - 7.3e-22 78.1 0.0 8.4e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCP38186.1 - 2.1e-17 63.6 0.0 3.6e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCP38186.1 - 4.7e-05 23.0 0.0 0.00011 21.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCP38186.1 - 0.013 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_2 PF03446.15 CCP38186.1 - 0.097 12.8 0.0 0.34 11.1 0.0 1.9 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_4 PF07993.12 CCP38186.1 - 0.11 11.7 0.1 0.18 10.9 0.1 1.4 1 0 0 1 1 1 0 Male sterility protein adh_short PF00106.25 CCP38186.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase SSB PF00436.25 CCP38187.1 - 0.012 15.7 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 0 Single-strand binding protein family SpvB PF03534.13 CCP38187.1 - 0.051 12.8 0.0 0.056 12.6 0.0 1.1 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein PsbI PF02532.14 CCP38188.1 - 1.1e-24 86.1 3.7 1.2e-24 86.0 3.7 1.0 1 0 0 1 1 1 1 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Anoctamin PF04547.12 CCP38188.1 - 0.016 14.1 0.7 0.016 14.1 0.7 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel Nodulin_late PF07127.11 CCP38188.1 - 0.22 11.9 1.0 0.22 11.9 1.0 1.2 1 0 0 1 1 1 0 Late nodulin protein CpeS PF09367.10 CCP38189.1 - 0.00034 20.6 0.4 0.3 11.0 0.0 2.1 1 1 0 2 2 2 2 CpeS-like protein zf-C3HC PF07967.13 CCP38189.1 - 0.024 14.7 0.4 0.035 14.2 0.4 1.2 1 0 0 1 1 1 0 C3HC zinc finger-like CemA PF03040.14 CCP38191.1 - 8.4e-97 323.6 8.1 1.1e-96 323.2 8.1 1.2 1 0 0 1 1 1 1 CemA family RVT_N PF13655.6 CCP38192.1 - 3.5e-09 36.8 2.6 4.4e-09 36.5 0.2 2.4 3 0 0 3 3 3 1 N-terminal domain of reverse transcriptase Ycf4 PF02392.16 CCP38193.1 - 5.1e-79 264.0 0.6 5.7e-79 263.8 0.6 1.0 1 0 0 1 1 1 1 Ycf4 DUF5381 PF17353.2 CCP38193.1 - 0.12 12.1 10.3 0.62 9.8 10.3 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5381) DUF202 PF02656.15 CCP38193.1 - 0.39 11.2 6.4 1.2 9.6 6.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF202) PetL PF05115.14 CCP38194.1 - 1.1e-11 44.5 7.5 1.1e-11 44.4 7.5 1.0 1 0 0 1 1 1 1 Cytochrome B6-F complex subunit VI (PetL) PsaL PF02605.15 CCP38195.1 - 5.3e-61 204.7 0.3 6.9e-61 204.3 0.3 1.1 1 0 0 1 1 1 1 Photosystem I reaction centre subunit XI DUF2976 PF11190.8 CCP38195.1 - 0.11 12.3 0.6 0.63 9.9 0.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2976) Ribosomal_L28 PF00830.19 CCP38197.1 - 1.4e-18 66.8 10.1 1.5e-18 66.7 10.1 1.0 1 0 0 1 1 1 1 Ribosomal L28 family Thioredoxin PF00085.20 CCP38198.1 - 4.8e-33 113.2 0.0 5.3e-33 113.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCP38198.1 - 2e-10 41.1 0.1 3.3e-10 40.4 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCP38198.1 - 2e-08 34.5 0.0 1.1e-06 28.9 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 CCP38198.1 - 2e-08 34.1 0.1 2.3e-08 33.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CCP38198.1 - 1.4e-05 25.1 0.0 1.6e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Redoxin PF08534.10 CCP38198.1 - 0.00013 21.7 0.4 0.0018 18.0 0.2 1.9 1 1 1 2 2 2 2 Redoxin Thioredoxin_3 PF13192.6 CCP38198.1 - 0.00017 21.5 0.4 0.00027 20.9 0.4 1.4 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 CCP38198.1 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CCP38198.1 - 0.0011 18.9 0.0 0.0014 18.6 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Fer4_13 PF13370.6 CCP38198.1 - 0.015 15.8 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I OST3_OST6 PF04756.13 CCP38198.1 - 0.029 13.7 0.0 0.029 13.7 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 CCP38198.1 - 0.031 14.5 0.0 0.063 13.5 0.0 1.6 1 1 0 1 1 1 0 Glutaredoxin HyaE PF07449.11 CCP38198.1 - 0.036 14.0 0.0 0.05 13.6 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE RuBisCO_large PF00016.20 CCP38199.1 - 2.1e-126 421.1 0.2 2.6e-126 420.8 0.2 1.1 1 0 0 1 1 1 1 Ribulose bisphosphate carboxylase large chain, catalytic domain RuBisCO_large_N PF02788.16 CCP38199.1 - 1.1e-44 151.4 0.1 3.7e-44 149.7 0.0 1.9 2 0 0 2 2 2 1 Ribulose bisphosphate carboxylase large chain, N-terminal domain RuBisCO_small PF00101.20 CCP38200.1 - 6e-38 128.7 0.0 8.4e-38 128.3 0.0 1.2 1 0 0 1 1 1 1 Ribulose bisphosphate carboxylase, small chain AAA_lid_6 PF17866.1 CCP38201.1 - 2e-16 59.9 2.2 8e-16 58.0 0.8 2.6 2 0 0 2 2 2 1 AAA lid domain AAA PF00004.29 CCP38201.1 - 1.2e-15 58.1 0.1 3.4e-15 56.6 0.0 1.9 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCP38201.1 - 1.4e-05 25.1 0.0 3.1e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCP38201.1 - 2.5e-05 24.5 1.5 0.28 11.5 0.1 3.4 2 1 2 4 4 4 2 AAA domain AAA_16 PF13191.6 CCP38201.1 - 0.00014 22.3 0.0 0.0016 18.9 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CCP38201.1 - 0.00021 20.8 0.3 0.015 14.7 0.2 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 CCP38201.1 - 0.0005 20.0 0.1 0.0011 18.9 0.1 1.8 1 1 0 1 1 1 1 NTPase AAA_2 PF07724.14 CCP38201.1 - 0.0012 19.0 0.0 0.0029 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CCP38201.1 - 0.0023 17.7 0.9 0.046 13.5 0.7 3.0 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 CCP38201.1 - 0.0032 17.2 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCP38201.1 - 0.0046 17.3 0.0 0.015 15.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 CCP38201.1 - 0.011 15.9 0.1 0.032 14.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCP38201.1 - 0.015 14.5 0.3 0.15 11.3 0.3 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Torsin PF06309.11 CCP38201.1 - 0.017 15.2 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 Torsin RNA_helicase PF00910.22 CCP38201.1 - 0.027 14.9 0.0 0.058 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ResIII PF04851.15 CCP38201.1 - 0.03 14.3 0.0 0.2 11.7 0.0 1.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit TBPIP PF07106.13 CCP38201.1 - 0.031 14.2 0.0 0.097 12.6 0.0 1.8 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain Sigma54_activat PF00158.26 CCP38201.1 - 0.035 13.8 0.1 1.4 8.6 0.1 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain KTI12 PF08433.10 CCP38201.1 - 0.046 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zot PF05707.12 CCP38201.1 - 0.055 13.1 0.5 4.1 7.0 0.1 2.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_28 PF13521.6 CCP38201.1 - 0.056 13.7 3.3 0.24 11.6 0.2 2.9 2 2 2 4 4 4 0 AAA domain CbiA PF01656.23 CCP38201.1 - 0.063 13.3 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain APS_kinase PF01583.20 CCP38201.1 - 0.068 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF5550 PF17704.1 CCP38201.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5550) AAA_18 PF13238.6 CCP38201.1 - 0.093 13.3 0.6 0.29 11.7 0.1 2.2 2 1 0 2 2 1 0 AAA domain PRK PF00485.18 CCP38201.1 - 0.098 12.4 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.22 CCP38201.1 - 0.11 12.1 0.1 0.27 10.8 0.1 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 CCP38201.1 - 0.14 11.7 0.5 0.52 9.9 0.5 2.2 1 1 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 CCP38201.1 - 0.18 10.6 0.8 0.26 10.2 0.1 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Thymidylate_kin PF02223.17 CCP38201.1 - 0.34 10.6 2.1 1.3 8.7 0.0 2.8 3 1 1 4 4 4 0 Thymidylate kinase AAA_17 PF13207.6 CCP38201.1 - 0.6 10.5 2.4 0.76 10.2 0.1 2.3 3 0 0 3 3 2 0 AAA domain Ycf34 PF10718.9 CCP38202.1 - 1.1e-20 74.1 2.1 1.3e-20 73.8 2.1 1.0 1 0 0 1 1 1 1 Hypothetical chloroplast protein Ycf34 ALS_ss_C PF10369.9 CCP38203.1 - 4.6e-25 87.6 0.8 8.2e-25 86.8 0.2 1.7 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 CCP38203.1 - 4.2e-17 61.7 0.0 5.6e-16 58.1 0.0 2.2 2 0 0 2 2 2 1 ACT domain ACT PF01842.25 CCP38203.1 - 2.5e-14 52.7 0.0 5.9e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 CCP38203.1 - 0.00016 22.2 0.0 0.00037 21.0 0.0 1.6 1 0 0 1 1 1 1 ACT domain IF3_C PF00707.22 CCP38204.1 - 2.1e-33 114.1 0.7 3.5e-33 113.4 0.7 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 CCP38204.1 - 3.2e-27 94.6 0.7 1.7e-26 92.2 0.2 2.2 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain AFOR_N PF02730.15 CCP38204.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain TMPIT PF07851.13 CCP38204.1 - 0.24 10.6 2.0 0.31 10.2 2.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Ribosomal_S4 PF00163.19 CCP38205.1 - 1e-23 84.0 3.0 1.6e-23 83.4 3.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 CCP38205.1 - 1.9e-14 53.1 0.0 3.7e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 S4 domain DUF3990 PF13151.6 CCP38206.1 - 0.03 14.0 3.9 0.03 14.0 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3990) Fe-S_biosyn PF01521.20 CCP38207.1 - 4e-21 75.3 0.1 4.4e-21 75.1 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF4346 PF14251.6 CCP38208.1 - 2.8e-07 30.6 0.2 4e-07 30.1 0.2 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4346) Phycobilisome PF00502.19 CCP38209.1 - 2.8e-47 160.5 0.5 3.2e-47 160.3 0.5 1.0 1 0 0 1 1 1 1 Phycobilisome protein SwrA PF17423.2 CCP38209.1 - 0.068 13.2 0.4 0.19 11.7 0.1 1.9 1 1 1 2 2 2 0 Swarming motility protein DUF565 PF04483.12 CCP38210.1 - 5.2e-18 65.3 0.2 5.2e-18 65.3 0.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF565) PBS_linker_poly PF00427.21 CCP38211.1 - 1.6e-39 134.8 0.1 2e-39 134.5 0.1 1.1 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide NblA PF04485.12 CCP38212.1 - 8.6e-14 51.7 1.5 9.4e-14 51.6 1.5 1.0 1 0 0 1 1 1 1 Phycobilisome degradation protein nblA Phycobilisome PF00502.19 CCP38213.1 - 8e-59 198.0 0.2 9e-59 197.9 0.2 1.0 1 0 0 1 1 1 1 Phycobilisome protein Phycobilisome PF00502.19 CCP38214.1 - 1e-43 148.9 0.0 1.2e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 Phycobilisome protein Cytochrom_C_asm PF01578.20 CCP38215.1 - 8.8e-76 254.4 19.2 8.8e-76 254.4 19.2 1.9 2 0 0 2 2 2 1 Cytochrome C assembly protein PSI_PSAK PF01241.18 CCP38216.1 - 3.5e-21 75.0 2.7 4.3e-21 74.7 2.7 1.1 1 0 0 1 1 1 1 Photosystem I psaG / psaK ACCA PF03255.14 CCP38217.1 - 8.2e-50 168.4 0.0 1.3e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Carboxyl_trans PF01039.22 CCP38217.1 - 1.7e-10 40.2 0.2 2.1e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain BILBO1_N PF18281.1 CCP38217.1 - 0.14 12.6 0.2 0.28 11.6 0.2 1.4 1 0 0 1 1 1 0 BILBO1 N-terminal domain MlaD PF02470.20 CCP38218.1 - 4.8e-14 52.4 0.1 9.3e-14 51.5 0.1 1.5 1 0 0 1 1 1 1 MlaD protein DUF561 PF04481.12 CCP38219.1 - 3.5e-80 268.7 16.7 4.5e-80 268.3 16.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF561) Fer4 PF00037.27 CCP38220.1 - 3.6e-12 45.6 15.9 4.3e-07 29.5 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CCP38220.1 - 1.6e-08 34.2 16.2 0.00012 22.0 2.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 CCP38220.1 - 3.7e-08 33.4 29.1 9.9e-05 22.4 19.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CCP38220.1 - 5.4e-08 33.3 16.9 1.2e-07 32.2 17.1 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CCP38220.1 - 1.1e-07 31.9 16.3 1.8e-07 31.2 16.4 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 CCP38220.1 - 2e-07 31.0 17.7 0.00024 21.4 2.4 2.6 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CCP38220.1 - 2.3e-07 30.5 16.4 0.002 18.1 3.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CCP38220.1 - 5.6e-07 29.6 32.8 6.5e-06 26.2 19.0 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CCP38220.1 - 6.4e-07 29.8 12.9 0.00036 21.0 2.1 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CCP38220.1 - 1.7e-06 28.8 12.3 0.0012 19.8 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CCP38220.1 - 0.0015 19.3 23.6 0.032 15.2 3.6 2.5 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 CCP38220.1 - 0.0016 18.9 17.2 0.015 15.8 5.3 2.2 1 1 1 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 CCP38220.1 - 0.0044 17.8 16.3 0.0054 17.5 2.4 2.1 1 1 2 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CCP38220.1 - 0.0068 16.8 18.3 0.012 16.1 2.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 CCP38220.1 - 0.02 15.6 12.6 0.18 12.6 3.4 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 CCP38220.1 - 0.099 12.8 15.7 0.14 12.4 2.2 2.1 1 1 0 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 CCP38220.1 - 0.59 10.3 6.8 1.1 9.5 6.8 1.5 1 1 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GATase_2 PF00310.21 CCP38221.1 - 4.6e-174 579.1 0.0 6.1e-174 578.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CCP38221.1 - 4.3e-158 526.3 0.8 6.5e-157 522.4 0.0 2.6 3 0 0 3 3 3 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CCP38221.1 - 2.8e-108 361.7 0.2 6.3e-106 353.9 0.0 2.3 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 CCP38221.1 - 3.6e-74 248.5 10.3 6.6e-74 247.6 10.3 1.4 1 0 0 1 1 1 1 GXGXG motif FMN_dh PF01070.18 CCP38221.1 - 0.0023 17.0 3.1 0.0046 16.0 3.1 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase RNA_pol_Rpb6 PF01192.22 CCP38222.1 - 0.00047 20.0 0.7 0.00084 19.2 0.3 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb6 Phycobilisome PF00502.19 CCP38223.1 - 5.8e-58 195.2 0.5 6.4e-58 195.1 0.5 1.0 1 0 0 1 1 1 1 Phycobilisome protein Phycobilisome PF00502.19 CCP38224.1 - 7.6e-49 165.6 0.2 8.5e-49 165.4 0.2 1.0 1 0 0 1 1 1 1 Phycobilisome protein Integrase_DNA PF02920.15 CCP38224.1 - 0.0043 16.7 0.0 0.0082 15.8 0.0 1.4 1 0 0 1 1 1 1 DNA binding domain of tn916 integrase Metalloenzyme PF01676.18 CCP38225.1 - 2.6e-83 279.2 0.2 3e-83 279.0 0.2 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CCP38225.1 - 8.8e-68 228.0 0.4 1.3e-67 227.5 0.4 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Sulfatase PF00884.23 CCP38225.1 - 3.5e-06 26.7 0.0 2.1e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CCP38225.1 - 8e-06 25.7 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 CCP38225.1 - 0.11 12.6 1.0 0.7 10.0 0.1 2.4 3 0 0 3 3 3 0 PglZ domain Gp49 PF05973.14 CCP38225.1 - 0.12 12.6 0.0 1.6 8.9 0.0 2.5 3 0 0 3 3 3 0 Phage derived protein Gp49-like (DUF891) Alk_phosphatase PF00245.20 CCP38225.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Alkaline phosphatase DUF98 PF01947.16 CCP38226.1 - 6.3e-30 104.1 0.2 3.2e-29 101.8 0.2 1.8 1 1 0 1 1 1 1 p-hydroxybenzoic acid synthase SecA_DEAD PF07517.14 CCP38227.1 - 1.4e-112 375.7 4.6 2.4e-112 374.9 4.6 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain SecA_SW PF07516.13 CCP38227.1 - 9.7e-52 175.9 10.3 9.7e-52 175.9 10.3 3.1 3 0 0 3 3 3 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 CCP38227.1 - 5.6e-37 126.8 1.5 3.1e-36 124.4 1.5 2.4 1 0 0 1 1 1 1 SecA preprotein cross-linking domain DEAD PF00270.29 CCP38227.1 - 4e-07 30.0 0.1 4e-07 30.0 0.1 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Lge1 PF11488.8 CCP38227.1 - 0.31 11.2 4.0 0.62 10.3 0.1 3.3 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Trp_syntA PF00290.20 CCP38228.1 - 2.4e-76 256.0 0.1 2.7e-76 255.8 0.1 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain IGPS PF00218.21 CCP38228.1 - 0.0013 17.9 0.1 0.0021 17.3 0.1 1.2 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 CCP38228.1 - 0.019 14.4 0.1 0.037 13.5 0.1 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein PcrB PF01884.17 CCP38228.1 - 0.076 12.5 0.2 0.87 9.0 0.0 2.2 1 1 0 2 2 2 0 PcrB family ATP_bind_3 PF01171.20 CCP38229.1 - 2.4e-39 135.0 1.1 2.4e-39 135.0 1.1 1.8 2 0 0 2 2 2 1 PP-loop family NAD_synthase PF02540.17 CCP38229.1 - 0.00017 20.8 0.3 0.00017 20.8 0.3 2.3 3 1 0 3 3 3 1 NAD synthase QueC PF06508.13 CCP38229.1 - 0.0026 17.3 1.5 0.053 13.0 0.2 2.6 2 1 1 3 3 3 2 Queuosine biosynthesis protein QueC Glutaredoxin PF00462.24 CCP38230.1 - 1e-18 67.3 0.0 1.4e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 CCP38230.1 - 0.0076 16.6 0.0 0.01 16.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain ATP-synt_ab_Xtn PF16886.5 CCP38230.1 - 0.023 14.6 0.1 0.032 14.1 0.1 1.2 1 0 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension PSII_Ycf12 PF05969.11 CCP38231.1 - 1.9e-17 62.9 2.7 2e-17 62.9 2.7 1.0 1 0 0 1 1 1 1 Photosystem II complex subunit Ycf12 FeThRed_B PF02943.15 CCP38232.1 - 5e-40 135.8 1.3 5.7e-40 135.6 1.3 1.0 1 0 0 1 1 1 1 Ferredoxin thioredoxin reductase catalytic beta chain PSI_8 PF00796.18 CCP38233.1 - 3.9e-10 39.4 8.8 4.4e-10 39.2 8.8 1.1 1 0 0 1 1 1 1 Photosystem I reaction centre subunit VIII PsbJ PF01788.17 CCP38234.1 - 2.1e-21 75.5 9.1 2.2e-21 75.4 9.1 1.0 1 0 0 1 1 1 1 PsbJ GPHR_N PF12537.8 CCP38234.1 - 1.1 9.4 5.2 1.3 9.2 5.2 1.1 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal PsbL PF02419.17 CCP38235.1 - 8.1e-25 86.5 3.2 8.7e-25 86.4 3.2 1.0 1 0 0 1 1 1 1 PsbL protein Cytochrom_B559 PF00283.19 CCP38236.1 - 2.3e-18 65.3 2.0 2.9e-18 65.0 2.0 1.2 1 0 0 1 1 1 1 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits Cytochrom_B559a PF00284.20 CCP38237.1 - 2.4e-23 81.6 0.5 3.2e-23 81.2 0.5 1.2 1 0 0 1 1 1 1 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit Cytochrom_B559 PF00283.19 CCP38237.1 - 2.1e-16 59.1 1.8 3.1e-16 58.5 1.8 1.3 1 0 0 1 1 1 1 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits MlaE PF02405.16 CCP38238.1 - 1.2e-61 208.1 23.4 1.4e-61 207.8 23.4 1.0 1 0 0 1 1 1 1 Permease MlaE AAA_lid_2 PF17863.1 CCP38239.1 - 2.1e-18 65.9 0.0 3.8e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 AAA lid domain Mg_chelatase PF01078.21 CCP38239.1 - 6.5e-13 48.5 0.0 2.3e-07 30.4 0.0 2.8 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI MCM PF00493.23 CCP38239.1 - 1.7e-07 30.6 0.0 0.00041 19.5 0.0 2.7 1 1 1 2 2 2 2 MCM P-loop domain AAA_5 PF07728.14 CCP38239.1 - 9.1e-07 29.0 0.0 0.021 14.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCP38239.1 - 8.2e-05 23.0 0.0 0.00026 21.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 CCP38239.1 - 0.0002 21.1 0.0 0.22 11.2 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 CCP38239.1 - 0.00024 21.4 0.0 0.00084 19.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CCP38239.1 - 0.0006 20.3 0.0 0.0069 16.8 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CCP38239.1 - 0.0022 17.6 0.0 0.0049 16.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_29 PF13555.6 CCP38239.1 - 0.0023 17.7 0.0 0.0058 16.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 CCP38239.1 - 0.0053 16.0 0.0 0.013 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 CCP38239.1 - 0.0058 17.2 0.1 0.041 14.4 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_28 PF13521.6 CCP38239.1 - 0.008 16.4 0.0 0.27 11.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.16 CCP38239.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_18 PF13238.6 CCP38239.1 - 0.012 16.2 0.2 0.086 13.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 CCP38239.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CCP38239.1 - 0.015 14.5 0.1 1.9 7.6 0.0 2.4 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_30 PF13604.6 CCP38239.1 - 0.026 14.2 0.3 0.5 10.1 0.0 2.4 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 CCP38239.1 - 0.072 13.5 0.0 0.19 12.1 0.0 1.7 2 0 0 2 2 1 0 RNA helicase ADK PF00406.22 CCP38239.1 - 0.081 13.0 0.4 0.25 11.5 0.0 1.9 2 1 0 2 2 2 0 Adenylate kinase AAA_23 PF13476.6 CCP38239.1 - 0.084 13.4 0.1 0.76 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CCP38239.1 - 0.092 13.1 0.0 1.4 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 CCP38239.1 - 0.18 11.3 1.5 0.87 9.1 0.2 2.3 2 1 0 2 2 2 0 HPr Serine kinase C-terminal domain PsaM PF07465.13 CCP38240.1 - 4.7e-14 51.8 2.2 5e-14 51.7 2.2 1.0 1 0 0 1 1 1 1 Photosystem I protein M (PsaM) CHGN PF05679.16 CDF32066.1 - 2.8e-48 165.0 0.0 3.8e-48 164.6 0.0 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 CDF32066.1 - 0.00073 19.2 1.1 0.0015 18.2 1.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase NB-ARC PF00931.22 CDF32067.1 - 6.8e-09 35.3 0.0 1.3e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain WD40 PF00400.32 CDF32067.1 - 1.7e-06 28.7 0.2 0.0025 18.6 0.1 4.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32067.1 - 5.8e-05 23.3 0.0 0.027 14.8 0.0 4.1 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.6 CDF32067.1 - 0.00045 20.6 0.0 0.0011 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDF32067.1 - 0.029 14.6 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF32067.1 - 0.042 14.4 0.2 0.21 12.1 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_25 PF13481.6 CDF32067.1 - 0.091 12.3 0.0 0.3 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDF32067.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDF32067.1 - 0.18 11.5 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain SF3b1 PF08920.10 CDF32068.1 - 2.4e-32 111.9 15.3 7.4e-29 100.7 9.6 3.7 1 1 1 2 2 2 2 Splicing factor 3B subunit 1 HEAT PF02985.22 CDF32068.1 - 1.7e-13 49.5 3.4 0.94 9.9 0.0 9.0 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 CDF32068.1 - 6.7e-11 42.4 6.1 0.26 11.7 0.0 7.7 6 2 1 8 8 8 3 HEAT repeats HEAT_EZ PF13513.6 CDF32068.1 - 3.7e-07 30.5 2.5 0.037 14.6 0.0 6.4 7 0 0 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 CDF32068.1 - 8.5e-07 29.1 0.0 0.12 12.4 0.0 4.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDF32068.1 - 0.00022 19.9 0.0 0.34 9.4 0.0 3.0 1 1 1 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 CDF32068.1 - 0.00045 20.8 0.1 2.1 9.0 0.0 3.9 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 CDF32068.1 - 0.00067 19.4 0.3 0.47 10.1 0.0 3.8 2 1 0 3 3 3 1 NUC173 domain DUF3385 PF11865.8 CDF32068.1 - 0.0021 18.0 0.4 15 5.5 0.0 5.0 5 1 1 6 6 6 1 Domain of unknown function (DUF3385) DUF4042 PF13251.6 CDF32068.1 - 0.026 14.2 0.0 17 5.0 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4042) EMC3_TMCO1 PF01956.16 CDF32069.1 - 6.3e-35 120.4 0.1 9.1e-35 119.9 0.1 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like 60KD_IMP PF02096.20 CDF32070.1 - 2.4e-23 82.8 0.1 3.4e-23 82.4 0.1 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Cupin_4 PF08007.12 CDF32072.1 - 1.5e-70 238.2 0.0 1.9e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein AraC_binding PF02311.19 CDF32072.1 - 0.00048 20.0 0.0 0.002 18.0 0.0 2.0 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 CDF32072.1 - 0.023 14.4 0.0 0.07 12.9 0.0 1.8 1 0 0 1 1 1 0 Cupin domain Asp_Arg_Hydrox PF05118.15 CDF32072.1 - 0.023 14.5 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Aspartyl/Asparaginyl beta-hydroxylase Cupin_1 PF00190.22 CDF32072.1 - 0.076 12.6 0.0 0.17 11.5 0.0 1.5 1 1 0 1 1 1 0 Cupin DUF3539 PF12058.8 CDF32072.1 - 0.13 12.4 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) Cupin_8 PF13621.6 CDF32072.1 - 0.21 11.3 0.0 0.41 10.3 0.0 1.4 1 0 0 1 1 1 0 Cupin-like domain Cullin PF00888.22 CDF32073.1 - 2.1e-189 631.1 11.4 4.3e-105 352.6 3.9 2.1 2 0 0 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 CDF32073.1 - 5.5e-26 90.4 1.2 1.6e-25 88.9 1.2 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF1474 PF07342.11 CDF32073.1 - 0.02 15.4 3.0 1.6 9.3 1.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) PXA PF02194.15 CDF32073.1 - 0.044 13.8 0.3 0.45 10.5 0.0 2.6 2 2 0 2 2 2 0 PXA domain Penicillinase_R PF03965.16 CDF32073.1 - 0.19 12.1 1.3 0.91 9.9 0.1 2.6 2 0 0 2 2 2 0 Penicillinase repressor Ribosomal_S6e PF01092.19 CDF32075.1 - 3.8e-48 162.6 0.2 7.3e-48 161.7 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e HEAT_2 PF13646.6 CDF32076.1 - 0.001 19.4 2.9 0.019 15.3 0.1 3.5 3 0 0 3 3 3 1 HEAT repeats Hydantoinase_B PF02538.14 CDF32076.1 - 0.051 12.0 0.0 0.082 11.3 0.0 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase UQ_con PF00179.26 CDF32078.1 - 8e-38 129.2 0.0 9.8e-38 129.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF32078.1 - 0.00032 20.4 0.0 0.0005 19.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Prok-E2_A PF14457.6 CDF32078.1 - 0.0076 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family A UEV PF05743.13 CDF32078.1 - 0.039 13.8 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 UEV domain bHLH-MYC_N PF14215.6 CDF32079.1 - 0.0035 17.7 0.0 0.0096 16.2 0.0 1.7 2 0 0 2 2 2 1 bHLH-MYC and R2R3-MYB transcription factors N-terminal HLH PF00010.26 CDF32079.1 - 0.012 15.5 0.6 0.022 14.7 0.6 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain PBP1_TM PF14812.6 CDF32079.1 - 0.018 15.4 7.7 0.033 14.6 7.7 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GAF PF01590.26 CDF32079.1 - 0.037 14.7 0.0 0.085 13.5 0.0 1.5 1 0 0 1 1 1 0 GAF domain CENP-B_dimeris PF09026.10 CDF32079.1 - 0.048 14.1 7.2 0.093 13.1 7.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Spt5_N PF11942.8 CDF32079.1 - 0.064 14.2 6.5 0.11 13.6 6.5 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF4611 PF15387.6 CDF32079.1 - 0.23 11.7 5.1 0.9 9.8 1.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) DAO PF01266.24 CDF32082.1 - 2e-52 179.0 0.9 2.9e-52 178.4 0.9 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDF32082.1 - 3.6e-11 42.8 0.8 3.3e-06 26.5 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CDF32082.1 - 5.4e-06 25.8 0.0 0.00074 18.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDF32082.1 - 5.2e-05 22.6 0.4 9.2e-05 21.8 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CDF32082.1 - 7.2e-05 23.0 0.5 0.00016 21.8 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CDF32082.1 - 8.3e-05 21.8 0.3 0.00014 21.1 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 CDF32082.1 - 0.0002 20.6 0.1 0.092 11.8 0.3 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 CDF32082.1 - 0.0028 16.4 0.2 0.039 12.7 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CDF32082.1 - 0.017 14.4 0.1 0.03 13.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CDF32082.1 - 0.03 14.9 0.0 0.081 13.5 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RunxI PF08504.11 CDF32082.1 - 1.2 9.9 7.4 0.22 12.2 1.1 3.0 2 1 1 3 3 3 0 Runx inhibition domain Nramp PF01566.18 CDF32083.1 - 2.2e-84 283.5 22.3 2.2e-84 283.5 22.3 1.7 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein DUF2929 PF11151.8 CDF32083.1 - 0.28 11.5 0.1 0.28 11.5 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) Dynamin_M PF01031.20 CDF32084.1 - 2.2e-56 191.2 0.0 3.2e-56 190.6 0.0 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CDF32084.1 - 4.8e-31 108.1 0.0 1e-30 107.0 0.0 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CDF32084.1 - 1.3e-05 25.2 0.5 0.00081 19.5 0.1 3.3 3 1 0 3 3 3 1 50S ribosome-binding GTPase Apolipoprotein PF01442.18 CDF32084.1 - 0.007 16.3 3.8 0.18 11.7 3.2 2.7 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain AAA_16 PF13191.6 CDF32084.1 - 0.041 14.3 0.3 2 8.8 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 CDF32084.1 - 0.054 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TerB_C PF15615.6 CDF32084.1 - 0.077 13.3 0.1 0.26 11.6 0.1 1.9 1 0 0 1 1 1 0 TerB-C domain FeoB_N PF02421.18 CDF32084.1 - 0.13 11.8 0.0 19 4.7 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_15 PF13175.6 CDF32084.1 - 0.15 11.7 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain SNF2_N PF00176.23 CDF32085.1 - 9.4e-55 185.7 0.0 1.9e-54 184.7 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3535 PF12054.8 CDF32085.1 - 2.6e-37 129.1 3.8 1.9e-34 119.7 0.9 4.6 4 1 0 4 4 4 1 Domain of unknown function (DUF3535) Helicase_C PF00271.31 CDF32085.1 - 1.8e-16 60.5 0.0 4.2e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 CDF32085.1 - 3e-14 51.9 14.9 0.31 11.4 0.1 10.1 10 0 0 10 10 10 4 HEAT repeat HEAT_2 PF13646.6 CDF32085.1 - 1.3e-10 41.5 19.5 0.00034 20.9 0.5 7.3 6 1 1 7 7 7 4 HEAT repeats HEAT_EZ PF13513.6 CDF32085.1 - 3.5e-07 30.6 25.6 0.23 12.0 0.2 8.5 8 1 1 9 9 9 4 HEAT-like repeat Cnd1 PF12717.7 CDF32085.1 - 0.00048 20.2 2.1 8.7 6.4 0.0 4.8 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDF32085.1 - 0.00094 19.7 1.7 2.8 8.6 0.0 4.3 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 CDF32085.1 - 0.008 15.8 0.8 1.1 8.7 0.0 4.2 4 1 1 5 5 5 1 CLASP N terminal Cnd3 PF12719.7 CDF32085.1 - 0.03 13.5 0.1 0.24 10.6 0.0 2.4 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain MMS19_N PF14500.6 CDF32085.1 - 0.094 12.3 0.4 1.1 8.8 0.0 2.9 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II IFRD PF05004.13 CDF32085.1 - 0.14 11.2 4.5 0.16 11.1 0.0 2.9 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) ArgJ PF01960.18 CDF32086.1 - 1.1e-135 452.2 12.3 1.2e-135 452.1 12.3 1.0 1 0 0 1 1 1 1 ArgJ family dCMP_cyt_deam_1 PF00383.23 CDF32087.1 - 8.6e-20 70.5 1.6 1.1e-19 70.1 1.6 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDF32087.1 - 2e-19 69.7 0.1 2.4e-19 69.5 0.1 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 CDF32087.1 - 3.4e-05 23.9 0.0 5.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 CDF32087.1 - 0.00025 21.1 4.6 0.019 15.0 1.4 2.2 1 1 1 2 2 2 2 Bd3614-like deaminase APOBEC_N PF08210.11 CDF32087.1 - 0.0003 20.7 0.0 0.00038 20.4 0.0 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 CDF32087.1 - 0.00076 19.6 0.0 0.001 19.2 0.0 1.1 1 0 0 1 1 1 1 APOBEC2 APOBEC3 PF18771.1 CDF32087.1 - 0.0011 19.0 0.0 0.0017 18.5 0.0 1.2 1 0 0 1 1 1 1 APOBEC3 NAD1 PF18778.1 CDF32087.1 - 0.0016 18.5 0.0 0.0022 18.1 0.0 1.1 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 NAD2 PF18782.1 CDF32087.1 - 0.041 14.0 0.0 0.051 13.7 0.0 1.1 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 CDF32087.1 - 0.09 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Glyco_hydro_47 PF01532.20 CDF32088.1 - 4.8e-80 269.7 0.0 8.2e-80 268.9 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Trigger_N PF05697.13 CDF32089.1 - 5.6e-29 101.3 1.2 5.6e-29 101.3 1.2 3.0 2 1 0 2 2 2 1 Bacterial trigger factor protein (TF) Trigger_C PF05698.14 CDF32089.1 - 2.5e-19 69.9 17.5 2.5e-19 69.9 17.5 2.0 2 0 0 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus FKBP_C PF00254.28 CDF32089.1 - 5.3e-06 26.7 0.1 0.00015 22.0 0.0 3.0 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF3783 PF12646.7 CDF32089.1 - 0.019 14.9 0.2 0.35 10.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) RisS_PPD PF16524.5 CDF32089.1 - 0.24 11.7 3.3 1.1 9.5 0.1 2.6 2 0 0 2 2 2 0 Periplasmic domain of Sensor histidine kinase RisS Alpha-amylase PF00128.24 CDF32090.1 - 1.5e-14 54.3 0.0 3.6e-14 53.1 0.0 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain PUD PF03714.14 CDF32090.1 - 1.4e-13 51.5 0.0 0.00044 21.1 0.2 3.7 3 0 0 3 3 3 3 Bacterial pullanase-associated domain CBM_48 PF02922.18 CDF32090.1 - 7.2e-08 32.7 0.0 2.5e-07 31.0 0.0 2.0 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) hDGE_amylase PF14701.6 CDF32090.1 - 0.00078 18.7 0.2 0.0014 17.8 0.2 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GatB_N PF02934.15 CDF32091.1 - 1.3e-104 349.4 0.0 1.7e-104 349.1 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 CDF32091.1 - 7.2e-43 146.0 0.5 1.1e-42 145.5 0.5 1.3 1 0 0 1 1 1 1 GatB domain Methyltransf_11 PF08241.12 CDF32094.1 - 6.3e-21 74.8 0.0 1e-20 74.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF32094.1 - 8.3e-18 64.9 0.0 1.4e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF32094.1 - 4.6e-15 55.8 0.0 6.1e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF32094.1 - 2.8e-14 53.0 0.0 4.5e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDF32094.1 - 3.7e-13 49.5 0.0 4.8e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF32094.1 - 6.7e-10 39.6 0.0 1.7e-09 38.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 CDF32094.1 - 1.7e-06 28.1 0.1 3.2e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.12 CDF32094.1 - 2.4e-06 27.3 0.0 4.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 CDF32094.1 - 5.8e-05 22.2 0.0 8e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DUF2194 PF09960.9 CDF32094.1 - 0.2 9.9 0.0 0.26 9.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) ubiquitin PF00240.23 CDF32095.1 - 1.7e-20 72.5 0.0 8.8e-10 38.2 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD_2 PF13881.6 CDF32095.1 - 7.1e-10 39.0 0.3 1.4e-05 25.1 0.1 3.2 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CDF32095.1 - 6.8e-08 33.0 0.2 0.00087 19.8 0.0 2.7 3 0 0 3 3 3 2 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 CDF32095.1 - 3.1e-07 30.7 0.0 0.0051 17.1 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD PF11976.8 CDF32095.1 - 5.6e-05 22.9 0.0 0.37 10.6 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 CDF32095.1 - 0.042 14.6 0.1 0.35 11.6 0.0 2.5 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD UN_NPL4 PF11543.8 CDF32095.1 - 0.046 14.2 0.1 0.43 11.1 0.0 2.5 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 DASH_Dad3 PF08656.10 CDF32095.1 - 0.11 12.6 0.4 5.1 7.2 0.2 3.0 3 0 0 3 3 3 0 DASH complex subunit Dad3 RAP1 PF07218.11 CDF32095.1 - 0.59 8.3 4.1 0.77 8.0 4.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CxxCxxCC PF03692.15 CDF32096.1 - 2.7e-11 44.0 5.6 5.1e-11 43.1 5.3 1.6 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain MMR_HSR1_Xtn PF16897.5 CDF32097.1 - 2.9e-32 110.8 0.1 4.8e-32 110.1 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 CDF32097.1 - 1.2e-19 70.4 0.0 2.7e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 CDF32097.1 - 7.8e-15 54.7 0.0 1.4e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 CDF32097.1 - 6.1e-08 32.3 0.0 2.5e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDF32097.1 - 0.00018 21.6 0.0 0.053 13.6 0.0 2.4 2 0 0 2 2 2 2 Dynamin family zf-ZPR1 PF03367.13 CDF32097.1 - 0.0081 16.0 0.1 2.7 7.8 0.0 2.5 3 0 0 3 3 3 2 ZPR1 zinc-finger domain CP12 PF02672.15 CDF32098.1 - 1.3e-24 86.7 3.7 1.6e-24 86.4 3.7 1.1 1 0 0 1 1 1 1 CP12 domain HORMA PF02301.18 CDF32099.1 - 6.6e-30 104.3 0.0 1.3e-29 103.3 0.0 1.5 1 1 0 1 1 1 1 HORMA domain DUF1348 PF07080.11 CDF32100.1 - 4.6e-64 214.2 4.0 5.3e-64 214.0 4.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 CDF32100.1 - 5.4e-08 33.4 3.5 6.8e-08 33.1 3.5 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CDF32100.1 - 2e-05 24.9 1.0 3e-05 24.4 1.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 CDF32100.1 - 0.13 12.1 0.3 0.15 11.8 0.3 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase F-box-like PF12937.7 CDF32102.1 - 6e-05 22.8 2.6 6e-05 22.8 2.6 2.0 2 0 0 2 2 2 1 F-box-like Prot_ATP_OB_N PF17758.1 CDF32102.1 - 0.046 13.4 0.1 0.19 11.4 0.1 2.2 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain GTP_EFTU PF00009.27 CDF32103.1 - 4.3e-34 117.8 0.5 1.4e-32 112.8 0.5 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CDF32103.1 - 1e-22 80.2 1.5 3.2e-22 78.7 0.7 2.1 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 CDF32103.1 - 7.3e-09 35.7 0.4 2.4e-08 34.1 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CDF32103.1 - 3.7e-08 33.6 1.2 0.00044 20.6 0.1 2.8 2 0 0 2 2 2 2 Elongation factor Tu domain 2 SRPRB PF09439.10 CDF32103.1 - 0.00031 20.2 0.0 0.0018 17.7 0.0 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDF32103.1 - 0.00039 20.6 0.0 0.00071 19.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 CDF32103.1 - 0.0018 18.1 0.0 0.14 11.9 0.0 2.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 CDF32103.1 - 0.0018 17.9 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 CDF32103.1 - 0.0039 16.7 0.0 0.011 15.2 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDF32103.1 - 0.012 15.7 0.0 0.085 12.9 0.0 2.0 1 1 1 2 2 2 0 Dynamin family Arf PF00025.21 CDF32103.1 - 0.03 13.8 0.0 0.064 12.7 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family TniB PF05621.11 CDF32103.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Oxysterol_BP PF01237.18 CDF32104.1 - 1.4e-34 119.6 2.1 3.9e-31 108.2 0.0 2.5 2 1 0 2 2 2 2 Oxysterol-binding protein Pyr_redox_2 PF07992.14 CDF32108.1 - 8.2e-51 173.0 0.6 9.8e-51 172.7 0.6 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF32108.1 - 1.6e-18 67.0 1.4 2.8e-16 59.9 0.2 3.0 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDF32108.1 - 4e-18 65.7 0.0 3.4e-16 59.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDF32108.1 - 0.00013 22.3 0.0 0.12 12.9 0.0 2.5 2 0 0 2 2 2 2 Putative NAD(P)-binding HI0933_like PF03486.14 CDF32108.1 - 0.00059 18.6 0.5 0.5 9.0 0.0 3.1 2 1 0 3 3 3 2 HI0933-like protein NAD_binding_9 PF13454.6 CDF32108.1 - 0.0011 19.0 0.1 0.029 14.4 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CDF32108.1 - 0.0012 18.1 0.2 0.016 14.5 0.0 2.5 3 0 0 3 3 3 1 Thi4 family Shikimate_DH PF01488.20 CDF32108.1 - 0.0017 18.4 0.4 0.75 9.9 0.0 2.6 3 0 0 3 3 2 2 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 CDF32108.1 - 0.0043 16.2 1.4 6.9 5.6 0.2 3.8 4 0 0 4 4 4 1 Glucose inhibited division protein A DAO PF01266.24 CDF32108.1 - 0.0071 16.0 0.3 0.6 9.6 0.0 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDF32108.1 - 0.016 15.4 0.2 0.19 12.0 0.1 2.5 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CDF32108.1 - 0.022 13.9 0.2 0.67 9.0 0.1 2.8 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 CDF32108.1 - 0.079 12.2 0.0 3.6 6.7 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain FAD_binding_2 PF00890.24 CDF32108.1 - 0.29 10.2 6.1 1.9 7.5 0.7 3.4 3 1 1 4 4 4 0 FAD binding domain DUF547 PF04784.14 CDF32113.1 - 1.2e-25 90.0 0.0 2e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DEP PF00610.21 CDF32113.1 - 0.0016 18.4 0.0 0.0064 16.5 0.0 2.1 1 1 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) S4 PF01479.25 CDF32113.1 - 0.04 13.6 0.1 0.11 12.3 0.1 1.7 1 1 0 1 1 1 0 S4 domain G2BR PF18442.1 CDF32113.1 - 0.08 12.6 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) Slx4 PF09494.10 CDF32114.1 - 0.0006 19.7 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease Nop53 PF07767.11 CDF32114.1 - 0.011 15.2 10.1 0.022 14.1 10.1 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PP_kinase_C_1 PF17941.1 CDF32115.1 - 2.1e-59 199.8 0.0 4.3e-59 198.8 0.0 1.6 1 0 0 1 1 1 1 Polyphosphate kinase C-terminal domain 1 PP_kinase_C PF13090.6 CDF32115.1 - 3.2e-56 189.5 0.0 3.3e-55 186.2 0.0 2.1 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 2 PP_kinase PF02503.17 CDF32115.1 - 9.2e-37 126.6 0.1 2.1e-36 125.4 0.1 1.6 1 0 0 1 1 1 1 Polyphosphate kinase middle domain PLDc_2 PF13091.6 CDF32115.1 - 3.2e-14 53.0 0.0 1.3e-06 28.4 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PP_kinase_N PF13089.6 CDF32115.1 - 7.3e-14 52.0 0.0 1.5e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Polyphosphate kinase N-terminal domain NUDIX PF00293.28 CDF32115.1 - 1e-09 38.6 0.1 2e-09 37.6 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain Strep_his_triad PF04270.13 CDF32115.1 - 0.16 12.0 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Streptococcal histidine triad protein DTHCT PF08070.11 CDF32116.1 - 6.6 7.5 11.0 0.2 12.4 0.8 3.5 3 0 0 3 3 3 0 DTHCT (NUC029) region Snf7 PF03357.21 CDF32118.1 - 9.9e-31 106.6 26.4 1.2e-30 106.3 26.2 1.3 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 CDF32118.1 - 0.022 14.7 4.3 0.036 14.0 4.3 1.4 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Lge1 PF11488.8 CDF32118.1 - 1.3 9.2 5.0 1.9 8.7 2.7 2.3 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Spc24 PF08286.11 CDF32118.1 - 7.2 6.9 10.1 3.7 7.8 6.7 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 LRR_8 PF13855.6 CDF32119.1 - 5.8e-22 77.2 25.2 1.4e-11 44.0 1.0 4.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CDF32119.1 - 2.6e-14 53.1 9.7 1.2e-05 25.5 0.6 4.8 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) Pkinase PF00069.25 CDF32119.1 - 9.2e-12 44.9 0.0 1.3e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain LRR_9 PF14580.6 CDF32119.1 - 0.00013 21.5 2.6 0.023 14.2 0.2 2.4 2 1 0 2 2 2 2 Leucine-rich repeat Kdo PF06293.14 CDF32119.1 - 0.0017 17.8 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF32119.1 - 0.0072 16.3 0.0 0.66 9.9 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 CDF32119.1 - 0.0082 15.5 0.0 0.019 14.3 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase LRR_1 PF00560.33 CDF32119.1 - 0.0092 16.4 3.4 99 4.1 0.0 5.7 6 1 0 6 6 6 0 Leucine Rich Repeat RIO1 PF01163.22 CDF32119.1 - 0.027 14.1 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family LRR_6 PF13516.6 CDF32119.1 - 0.75 10.0 3.7 88 3.6 0.2 4.5 5 0 0 5 5 5 0 Leucine Rich repeat LON_substr_bdg PF02190.16 CDF32120.1 - 1.5e-08 34.8 0.0 4.1e-08 33.4 0.0 1.6 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Alpha-amylase PF00128.24 CDF32121.1 - 4.8e-17 62.5 0.0 1.4e-11 44.6 0.0 3.1 2 1 0 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 CDF32121.1 - 1.7e-10 41.1 0.0 5.8e-10 39.4 0.0 2.0 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) GHL5 PF14872.6 CDF32121.1 - 0.041 11.9 0.0 0.061 11.4 0.0 1.1 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 Pro_isomerase PF00160.21 CDF32123.1 - 3.9e-43 147.5 0.4 4.5e-43 147.3 0.4 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3337 PF11816.8 CDF32125.1 - 2.4e-26 92.7 0.0 3.9e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 CDF32125.1 - 1e-25 89.5 17.9 1.1e-06 29.2 0.4 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32125.1 - 1.4e-07 31.7 0.1 0.00092 19.5 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF32125.1 - 0.00019 20.9 0.0 0.00092 18.6 0.0 1.9 1 1 0 1 1 1 1 WD40-like domain RAWUL PF16207.5 CDF32125.1 - 0.0072 17.0 0.0 0.016 15.8 0.0 1.6 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like Nup160 PF11715.8 CDF32125.1 - 0.23 10.1 6.8 17 3.9 0.1 4.1 3 1 1 4 4 4 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CDF32126.1 - 0.013 15.7 0.0 0.11 12.8 0.0 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RecR PF02132.15 CDF32128.1 - 0.06 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 RecR protein Pro_isomerase PF00160.21 CDF32130.1 - 6.7e-40 136.9 0.0 7.7e-40 136.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-rbx1 PF12678.7 CDF32131.1 - 1.3e-08 34.9 5.9 2.9e-08 33.9 5.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDF32131.1 - 5.4e-08 33.0 8.4 1e-07 32.2 8.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CDF32131.1 - 1.7e-07 31.1 6.1 2e-07 30.9 2.5 2.5 2 1 1 3 3 3 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CDF32131.1 - 2.2e-07 30.8 1.5 3.6e-07 30.1 1.5 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 CDF32131.1 - 2.9e-06 27.1 8.1 5e-06 26.3 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF32131.1 - 0.00011 22.0 8.1 0.00035 20.3 8.2 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF32131.1 - 0.00035 20.3 10.0 0.00086 19.0 5.7 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 CDF32131.1 - 0.00052 19.9 6.8 0.001 19.0 6.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDF32131.1 - 0.00072 19.7 6.5 0.0022 18.1 6.7 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 CDF32131.1 - 0.0029 17.4 2.8 0.011 15.6 3.1 1.7 1 1 1 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 CDF32131.1 - 0.0045 16.8 4.1 0.0045 16.8 4.1 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDF32131.1 - 0.022 14.6 4.9 0.041 13.8 4.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CDF32131.1 - 0.2 11.8 4.7 0.47 10.6 4.7 1.7 1 1 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 CDF32131.1 - 2.2 8.4 10.5 10 6.3 3.4 2.8 2 1 0 2 2 2 0 Zinc-finger zf-C2H2 PF00096.26 CDF32132.1 - 3.2e-12 46.2 11.7 0.00037 20.8 0.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF32132.1 - 2e-09 37.5 13.3 0.0054 17.5 1.1 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF32132.1 - 4.8e-07 29.9 16.3 0.001 19.4 0.5 5.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_3rep PF18868.1 CDF32132.1 - 1.2e-05 26.0 6.8 0.00019 22.1 1.7 2.7 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 CDF32132.1 - 0.00014 22.0 1.5 0.089 13.1 0.0 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_12 PF18658.1 CDF32132.1 - 0.00082 18.9 2.6 0.14 11.7 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger C2H2-type zf-C2HE PF16278.5 CDF32132.1 - 0.0018 18.7 4.5 8.6 6.9 1.0 3.6 2 1 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 CDF32132.1 - 0.0033 17.8 4.9 0.41 11.1 0.2 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 CDF32132.1 - 0.011 15.5 7.0 0.58 10.0 0.2 3.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Actin_micro PF17003.5 CDF32132.1 - 0.018 14.3 4.9 0.64 9.1 0.3 2.6 1 1 2 3 3 3 0 Putative actin-like family BolA PF01722.18 CDF32132.1 - 0.084 13.2 1.5 0.97 9.8 0.0 2.7 2 1 0 2 2 2 0 BolA-like protein C1_2 PF03107.16 CDF32132.1 - 0.13 12.6 5.2 22 5.5 0.3 3.6 3 0 0 3 3 3 0 C1 domain zf-met2 PF12907.7 CDF32132.1 - 0.27 11.4 4.2 0.32 11.2 0.1 2.8 3 0 0 3 3 3 0 Zinc-binding zf_C2H2_ZHX PF18387.1 CDF32132.1 - 0.61 9.8 10.2 0.78 9.4 0.4 3.3 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Zn-ribbon_8 PF09723.10 CDF32132.1 - 0.61 10.2 3.0 8.7 6.6 0.8 2.9 2 1 0 2 2 2 0 Zinc ribbon domain Stc1 PF12898.7 CDF32132.1 - 0.84 10.2 5.5 3.1 8.4 0.5 2.5 2 0 0 2 2 2 0 Stc1 domain zinc-ribbons_6 PF07191.12 CDF32132.1 - 2.3 8.2 5.9 5.1 7.1 0.4 2.9 2 1 0 2 2 2 0 zinc-ribbons zf-C2H2_11 PF16622.5 CDF32132.1 - 3.9 7.3 11.9 4.8 7.0 2.0 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 CDF32132.1 - 5.1 7.5 7.2 4.3 7.7 2.8 2.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CDF32132.1 - 9.3 6.4 9.5 1.1 9.3 0.4 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger SNARE PF05739.19 CDF32133.1 - 1.7e-10 40.7 0.0 3.5e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 CDF32133.1 - 4.4e-06 26.5 0.7 0.00056 19.6 0.0 2.4 2 0 0 2 2 2 2 Syntaxin Syntaxin-5_N PF11416.8 CDF32133.1 - 0.00082 18.5 0.0 0.0024 17.0 0.0 1.9 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain DUF16 PF01519.16 CDF32133.1 - 0.012 16.1 0.6 0.041 14.4 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.12 CDF32133.1 - 0.085 12.7 0.4 2.6 7.8 0.1 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF1930 PF09122.10 CDF32133.1 - 0.16 12.0 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1930) MCPsignal PF00015.21 CDF32133.1 - 0.24 11.2 2.5 7.7 6.3 0.3 2.3 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.12 CDF32133.1 - 0.26 11.8 1.0 18 5.9 0.0 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TAP42 PF04177.12 CDF32134.1 - 2.6e-68 230.5 7.9 3.1e-68 230.3 7.9 1.0 1 0 0 1 1 1 1 TAP42-like family PI3Ka PF00613.20 CDF32134.1 - 0.0052 16.2 0.0 0.014 14.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Synaptobrevin PF00957.21 CDF32135.1 - 1.7e-26 91.8 5.9 2.8e-26 91.1 5.9 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CDF32135.1 - 6.8e-11 42.1 0.0 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain MCU PF04678.13 CDF32135.1 - 0.025 14.7 0.2 0.037 14.1 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Tex_N PF09371.10 CDF32135.1 - 0.046 13.4 0.2 0.095 12.4 0.1 1.5 2 0 0 2 2 2 0 Tex-like protein N-terminal domain DUF2165 PF09933.9 CDF32135.1 - 0.085 12.9 0.4 0.14 12.2 0.4 1.3 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) IF-2B PF01008.17 CDF32136.1 - 5.8e-13 48.7 0.0 6.4e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family GGDEF_2 PF17853.1 CDF32136.1 - 0.031 14.5 0.4 0.36 11.1 0.3 2.4 1 1 1 2 2 2 0 GGDEF-like domain PseudoU_synth_2 PF00849.22 CDF32137.1 - 1.5e-31 109.7 0.1 3e-31 108.7 0.1 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase Pentapeptide PF00805.22 CDF32138.1 - 1.4e-20 72.5 21.1 5.1e-11 42.0 4.7 3.6 4 0 0 4 4 4 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CDF32138.1 - 5.1e-15 55.4 5.9 5e-13 49.0 1.5 2.5 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CDF32138.1 - 2.6e-13 49.9 14.1 3.3e-07 30.4 1.8 3.3 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) CfAFP PF05264.11 CDF32138.1 - 0.00031 20.7 2.1 0.0006 19.8 0.1 1.9 2 0 0 2 2 2 1 Choristoneura fumiferana antifreeze protein (CfAFP) Tic22 PF04278.12 CDF32139.1 - 1.7e-22 80.1 0.1 3.4e-22 79.0 0.0 1.4 1 1 1 2 2 2 1 Tic22-like family DUF4342 PF14242.6 CDF32139.1 - 0.098 12.7 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) Filament PF00038.21 CDF32139.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Intermediate filament protein Citrate_synt PF00285.21 CDF32141.1 - 9.4e-21 74.3 0.0 6.1e-17 61.7 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 CDF32141.1 - 2.2e-09 37.3 0.1 4e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CDF32141.1 - 0.0002 21.2 0.1 0.002 17.9 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Glucokinase PF02685.16 CDF32142.1 - 8.6e-84 281.2 0.0 1.5e-83 280.4 0.0 1.4 1 1 0 1 1 1 1 Glucokinase RNase_Zc3h12a PF11977.8 CDF32144.1 - 2.5e-17 63.1 0.0 4.3e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain PRORP PF16953.5 CDF32144.1 - 9.4e-05 22.0 0.0 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein-only RNase P DUF1690 PF07956.11 CDF32144.1 - 0.44 11.0 5.2 0.83 10.1 5.2 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) P5CR_dimer PF14748.6 CDF32145.1 - 1.1e-38 131.7 1.5 2e-38 130.8 1.5 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CDF32145.1 - 2.2e-13 50.6 0.0 4.7e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CDF32145.1 - 0.045 13.8 0.1 0.086 12.9 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SRPRB PF09439.10 CDF32147.1 - 3e-23 82.2 0.0 3.8e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 CDF32147.1 - 9.5e-09 34.9 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDF32147.1 - 6.5e-05 22.6 0.0 0.00054 19.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDF32147.1 - 0.00039 20.5 0.0 0.00069 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CDF32147.1 - 0.0043 17.3 0.0 0.0076 16.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase peroxidase PF00141.23 CDF32149.1 - 3.3e-49 167.6 0.0 5e-49 167.1 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Ham1p_like PF01725.16 CDF32150.1 - 6.9e-54 182.6 0.0 7.7e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family SWIRM-assoc_2 PF16496.5 CDF32151.1 - 1.7e-60 205.1 0.5 1.7e-60 205.1 0.5 1.9 1 1 0 1 1 1 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 CDF32151.1 - 3.1e-28 97.9 0.0 2.2e-27 95.2 0.0 2.2 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 CDF32151.1 - 4.7e-15 55.3 11.2 1.2e-14 54.0 11.2 1.7 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 CDF32151.1 - 5.4e-10 39.3 0.4 1.1e-09 38.3 0.1 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF32151.1 - 6.2e-07 29.6 0.2 5.2e-06 26.6 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 CDF32151.1 - 2.9e-06 27.0 5.0 5e-06 26.2 5.0 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 CDF32151.1 - 0.024 15.0 4.6 0.053 13.8 4.6 1.5 1 0 0 1 1 1 0 C1 domain CTNNB1_binding PF08347.11 CDF32151.1 - 4.5 7.4 15.7 2.5 8.3 3.8 2.8 2 0 0 2 2 2 0 N-terminal CTNNB1 binding ABC2_membrane PF01061.24 CDF32154.1 - 2.6e-44 151.1 8.5 3.6e-44 150.7 8.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CDF32154.1 - 9.6e-25 87.7 0.1 1.6e-24 87.0 0.1 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CDF32154.1 - 4.7e-06 26.6 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 CDF32154.1 - 5.8e-05 23.0 1.9 0.027 14.3 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDF32154.1 - 7.7e-05 23.1 0.1 0.00013 22.4 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 CDF32154.1 - 0.0021 17.6 0.1 0.0068 15.9 0.1 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 CDF32154.1 - 0.0036 16.4 0.1 0.0058 15.7 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC2_membrane_3 PF12698.7 CDF32154.1 - 0.004 16.3 9.9 0.0062 15.7 9.9 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_28 PF13521.6 CDF32154.1 - 0.012 15.8 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDF32154.1 - 0.013 15.8 0.3 0.031 14.5 0.3 1.8 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 CDF32154.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_29 PF13555.6 CDF32154.1 - 0.021 14.5 0.6 0.047 13.4 0.6 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sep15_SelM PF08806.11 CDF32154.1 - 0.027 14.6 0.0 0.089 13.0 0.0 1.8 2 0 0 2 2 1 0 Sep15/SelM redox domain NB-ARC PF00931.22 CDF32154.1 - 0.03 13.5 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 CDF32154.1 - 0.038 14.5 0.0 0.086 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 CDF32154.1 - 0.068 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.23 CDF32154.1 - 0.069 13.2 0.6 0.15 12.1 0.6 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Rad17 PF03215.15 CDF32154.1 - 0.081 12.8 0.2 0.52 10.2 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain ATP-synt_ab PF00006.25 CDF32154.1 - 0.095 12.3 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.12 CDF32154.1 - 0.12 12.3 0.3 0.25 11.2 0.3 1.6 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 CDF32154.1 - 0.16 11.8 0.4 2.3 8.1 0.3 2.2 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 CDF32154.1 - 0.17 11.1 0.0 0.33 10.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 CDF32154.1 - 0.17 11.4 0.2 0.43 10.1 0.2 1.6 1 0 0 1 1 1 0 AAA domain DUF21 PF01595.20 CDF32154.1 - 0.25 11.0 2.0 0.62 9.7 2.0 1.6 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain AAA_23 PF13476.6 CDF32154.1 - 0.59 10.6 1.6 1 9.8 0.5 1.8 2 0 0 2 2 2 0 AAA domain Thioredoxin PF00085.20 CDF32155.1 - 1.7e-60 201.4 0.1 7.8e-32 109.3 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CDF32155.1 - 1.2e-33 116.6 0.1 6.5e-23 81.6 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDF32155.1 - 2e-10 41.1 2.6 3.2e-06 27.6 0.2 4.2 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDF32155.1 - 3.8e-09 36.6 0.0 0.00088 19.4 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CDF32155.1 - 4.1e-08 33.4 0.4 0.3 11.4 0.0 4.8 4 1 1 5 5 5 3 Thioredoxin-like AhpC-TSA PF00578.21 CDF32155.1 - 1.3e-05 25.1 0.0 0.0054 16.6 0.0 2.7 2 0 0 2 2 2 1 AhpC/TSA family TraF PF13728.6 CDF32155.1 - 3.3e-05 23.8 1.0 0.038 13.8 0.0 2.7 3 0 0 3 3 2 2 F plasmid transfer operon protein Glutaredoxin PF00462.24 CDF32155.1 - 4.4e-05 23.6 0.0 0.12 12.6 0.0 2.7 2 0 0 2 2 2 2 Glutaredoxin Thioredoxin_3 PF13192.6 CDF32155.1 - 7.4e-05 22.7 0.0 0.012 15.7 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin domain Redoxin PF08534.10 CDF32155.1 - 0.003 17.3 0.1 4 7.1 0.0 3.0 3 0 0 3 3 3 2 Redoxin HyaE PF07449.11 CDF32155.1 - 0.013 15.4 0.0 1.2 9.1 0.0 3.0 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 CDF32155.1 - 0.032 14.0 0.1 0.34 10.7 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin OST3_OST6 PF04756.13 CDF32155.1 - 0.13 11.6 0.0 5.7 6.2 0.0 2.2 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family CPSase_L_D2 PF02786.17 CDF32157.1 - 1.6e-102 341.5 0.3 2.5e-66 223.2 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CDF32157.1 - 1.2e-39 135.4 0.2 2.5e-39 134.4 0.2 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 CDF32157.1 - 2.5e-11 43.6 0.0 1.1e-10 41.5 0.0 2.2 2 0 0 2 2 2 1 MGS-like domain ATP-grasp PF02222.22 CDF32157.1 - 3.2e-11 43.1 0.1 1.5e-08 34.4 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CDF32157.1 - 2e-08 34.0 0.2 0.0033 17.1 0.1 3.2 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 CDF32157.1 - 2.3e-08 33.8 0.5 0.0029 17.2 0.0 3.1 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 CDF32157.1 - 9.7e-08 31.8 0.0 0.0035 17.0 0.0 3.4 2 1 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 CDF32157.1 - 6.6e-06 26.0 0.1 0.15 11.8 0.0 2.4 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 CDF32157.1 - 1.2e-05 25.4 0.1 0.017 15.2 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_2 PF08442.10 CDF32157.1 - 1.7e-05 24.5 0.2 0.64 9.5 0.0 3.4 2 1 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 CDF32157.1 - 7.7e-05 22.4 0.0 0.0081 15.8 0.0 2.8 3 0 0 3 3 3 1 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 CDF32157.1 - 0.0021 17.6 0.0 0.026 14.0 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain APC_r PF05923.12 CDF32157.1 - 0.087 12.6 0.2 7.4 6.4 0.0 2.6 2 0 0 2 2 2 0 APC repeat FAD_binding_7 PF03441.14 CDF32158.1 - 3.9e-69 232.2 0.0 3.9e-69 232.2 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CDF32158.1 - 2e-40 138.5 1.3 2.7e-40 138.0 0.0 1.8 2 0 0 2 2 2 1 DNA photolyase SNF2_N PF00176.23 CDF32159.1 - 1.2e-65 221.6 0.1 2.1e-65 220.7 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF32159.1 - 2.2e-19 69.8 0.0 7.3e-19 68.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 CDF32159.1 - 7.9e-17 60.9 2.4 1.2e-11 44.3 0.1 3.0 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 CDF32159.1 - 2e-08 34.5 2.1 3.9e-08 33.6 0.3 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) ResIII PF04851.15 CDF32159.1 - 8.2e-08 32.4 0.0 3e-07 30.6 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SLIDE PF09111.10 CDF32159.1 - 0.00017 21.6 0.2 0.0015 18.5 0.1 2.7 1 1 1 2 2 2 1 SLIDE SWI2_SNF2 PF18766.1 CDF32159.1 - 0.0021 17.8 0.0 0.0062 16.2 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HEPN_SAV_6107 PF18726.1 CDF32159.1 - 0.026 15.0 3.6 1.2 9.6 0.1 3.2 2 0 0 2 2 2 0 SAV_6107-like HEPN CHDCT2 PF08074.11 CDF32159.1 - 0.063 13.5 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Prenyltransf PF01255.19 CDF32162.1 - 2e-28 99.4 0.0 2.6e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase cobW PF02492.19 CDF32164.1 - 2.2e-52 177.2 2.5 3.5e-52 176.6 1.2 1.9 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CDF32164.1 - 1.9e-40 136.7 0.0 6.5e-20 70.9 0.0 2.4 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.6 CDF32164.1 - 0.01 16.2 0.0 0.027 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDF32164.1 - 0.018 15.1 0.3 0.48 10.5 0.1 2.8 1 1 0 2 2 2 0 50S ribosome-binding GTPase MobB PF03205.14 CDF32164.1 - 0.029 14.3 0.1 0.12 12.3 0.1 2.0 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.18 CDF32164.1 - 0.042 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RsgA_GTPase PF03193.16 CDF32164.1 - 0.047 13.6 0.7 4.6 7.1 0.0 2.9 2 1 0 3 3 3 0 RsgA GTPase ATPase_2 PF01637.18 CDF32164.1 - 0.05 13.5 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 CDF32164.1 - 0.062 13.0 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 CDF32164.1 - 0.076 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 CDF32164.1 - 0.081 12.7 0.9 0.39 10.5 0.9 1.9 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 CDF32164.1 - 0.09 13.3 0.0 0.3 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF32164.1 - 0.12 12.9 0.0 0.52 10.8 0.0 2.1 2 1 0 2 2 1 0 ABC transporter PAP_assoc PF03828.19 CDF32165.1 - 2.3e-10 40.5 1.2 9.2e-06 25.8 0.2 2.6 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDF32165.1 - 9.8e-06 25.8 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_central PF04928.17 CDF32165.1 - 0.00063 18.8 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain Nrap_D2 PF17403.2 CDF32165.1 - 0.0063 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain Plant_tran PF04827.14 CDF32166.1 - 4.3e-40 137.5 0.0 6.9e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF32166.1 - 0.00063 19.4 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HIPIP PF01355.17 CDF32168.1 - 0.08 13.3 0.1 0.097 13.0 0.1 1.3 1 1 0 1 1 1 0 High potential iron-sulfur protein DEAD PF00270.29 CDF32169.1 - 3.9e-25 88.6 0.2 9.3e-24 84.1 0.2 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF32169.1 - 5.6e-22 78.2 0.0 2.7e-21 76.0 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF32169.1 - 3.7e-05 23.8 0.0 8.8e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CDF32169.1 - 0.043 13.5 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_22 PF13401.6 CDF32169.1 - 0.044 14.1 0.7 2.7 8.3 0.7 2.5 1 1 0 1 1 1 0 AAA domain SecA_DEAD PF07517.14 CDF32169.1 - 0.22 10.8 0.0 16 4.7 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain Archease PF01951.16 CDF32170.1 - 8.1e-41 139.5 0.8 9.7e-41 139.2 0.8 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) Hint PF01079.20 CDF32172.1 - 2.8e-28 98.9 0.0 5.2e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Hint module PIF1 PF05970.14 CDF32173.1 - 2.1e-93 313.4 0.0 3.1e-93 312.8 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF32173.1 - 2e-59 201.0 0.0 4.3e-59 199.9 0.0 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF32173.1 - 2.3e-06 27.5 0.0 4.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF32173.1 - 0.041 11.8 0.0 0.066 11.1 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF32173.1 - 0.09 12.4 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus UvrD_C_2 PF13538.6 CDF32173.1 - 0.1 12.5 0.0 0.7 9.8 0.0 2.4 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain S4 PF01479.25 CDF32175.1 - 8.1e-13 47.9 3.0 3.1e-12 46.0 1.6 2.4 1 1 1 2 2 2 1 S4 domain PseudoU_synth_2 PF00849.22 CDF32175.1 - 0.0022 18.1 0.1 0.0058 16.7 0.1 1.7 1 1 0 1 1 1 1 RNA pseudouridylate synthase zf-B_box PF00643.24 CDF32176.1 - 3.3e-11 43.1 19.9 4.7e-06 26.6 8.4 2.4 2 0 0 2 2 2 2 B-box zinc finger zf-C3HC4_3 PF13920.6 CDF32176.1 - 5 7.1 19.9 2.6 8.0 3.3 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PAF PF15715.5 CDF32178.1 - 0.011 16.3 2.3 0.019 15.6 2.3 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain BTRD1 PF17660.1 CDF32179.1 - 9.3e-06 25.4 0.0 0.071 12.9 0.0 3.2 3 0 0 3 3 3 2 Bacterial tandem repeat domain 1 Amino_oxidase PF01593.24 CDF32180.1 - 6.3e-10 38.9 0.0 2.3e-09 37.1 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF32180.1 - 1.1e-08 35.1 0.0 2.5e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDF32180.1 - 0.018 14.3 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF32180.1 - 0.039 12.7 0.1 0.078 11.7 0.0 1.5 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 CDF32180.1 - 0.071 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.32 CDF32181.1 - 5e-60 198.0 29.4 3.2e-09 37.2 0.2 8.5 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32181.1 - 4e-17 62.3 10.6 0.00028 21.1 0.1 7.2 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF32181.1 - 5.2e-12 45.2 7.7 2.2 6.8 0.0 7.8 3 1 3 8 8 8 7 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF32181.1 - 6.3e-07 28.7 2.8 9 5.1 0.0 6.3 1 1 6 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF32181.1 - 0.00018 21.9 16.6 0.86 10.2 0.0 7.3 3 3 5 8 8 8 1 PQQ-like domain WD40_like PF17005.5 CDF32181.1 - 0.00026 20.4 0.1 10 5.3 0.0 5.6 6 1 1 7 7 7 1 WD40-like domain PQQ PF01011.21 CDF32181.1 - 0.00074 19.3 0.0 51 4.1 0.0 5.4 6 0 0 6 6 6 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 CDF32181.1 - 0.011 14.2 16.9 0.023 13.2 1.0 3.1 1 1 1 3 3 3 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 CDF32181.1 - 0.021 13.7 0.7 0.8 8.5 0.0 2.9 1 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) VID27 PF08553.10 CDF32181.1 - 0.034 13.2 0.1 10 5.1 0.0 2.8 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain PQQ_2 PF13360.6 CDF32181.1 - 0.087 12.4 23.8 0.055 13.0 10.2 2.3 1 1 1 2 2 2 0 PQQ-like domain WSC PF01822.19 CDF32181.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 WSC domain Frtz PF11768.8 CDF32181.1 - 0.25 9.6 0.0 65 1.6 0.0 3.8 3 2 3 6 6 6 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF727 PF05303.12 CDF32181.1 - 1.8 8.7 9.2 6.2 6.9 0.0 5.3 6 1 2 8 8 8 0 Protein of unknown function (DUF727) Plant_tran PF04827.14 CDF32185.1 - 3.2e-67 226.1 0.0 4.1e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF32185.1 - 3.4e-11 43.1 0.0 5.8e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Cauli_VI PF01693.16 CDF32185.1 - 0.016 15.5 0.1 0.016 15.5 0.1 1.8 2 0 0 2 2 2 0 Caulimovirus viroplasmin p450 PF00067.22 CDF32186.1 - 4.4e-66 223.5 0.0 5.8e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CDF32188.1 - 3.5e-07 29.9 0.0 8.1e-07 28.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain APG6_N PF17675.1 CDF32188.1 - 0.0067 17.0 0.3 0.012 16.1 0.3 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region CENP-H PF05837.12 CDF32188.1 - 0.019 15.3 0.5 0.034 14.5 0.5 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Pkinase PF00069.25 CDF32189.1 - 1e-19 70.9 0.0 1.2e-19 70.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32189.1 - 3e-13 49.7 0.0 3.5e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF32189.1 - 9.3e-09 34.5 0.0 1.1e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF32189.1 - 0.0088 16.0 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 CDF32190.1 - 3.6e-52 177.3 0.0 4.2e-52 177.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32190.1 - 8.9e-20 71.1 0.0 1.1e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF32190.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CDF32191.1 - 9.9e-06 25.1 0.0 4.8e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain DUF2085 PF09858.9 CDF32192.1 - 0.13 12.8 1.4 0.42 11.1 0.0 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2085) DUF423 PF04241.15 CDF32192.1 - 3.7 7.8 5.3 0.88 9.8 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF423) HIP1_clath_bdg PF16515.5 CDF32195.1 - 0.013 16.1 4.5 0.14 12.8 0.1 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MotB_plug PF13677.6 CDF32195.1 - 0.14 11.7 0.0 7.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB DHR10 PF18595.1 CDF32195.1 - 0.22 11.6 6.6 0.59 10.2 5.8 1.8 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain E3_UFM1_ligase PF09743.9 CDF32197.1 - 0.031 13.9 0.0 0.044 13.4 0.0 1.1 1 0 0 1 1 1 0 E3 UFM1-protein ligase 1 Asp_Arg_Hydrox PF05118.15 CDF32197.1 - 0.12 12.2 0.9 0.41 10.5 0.9 1.9 1 1 0 1 1 1 0 Aspartyl/Asparaginyl beta-hydroxylase Fer2_3 PF13085.6 CDF32200.1 - 4.1e-20 71.8 0.4 9.9e-20 70.6 0.4 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Spore-coat_CotD PF11122.8 CDF32200.1 - 1.1 10.1 4.7 0.37 11.6 0.9 2.1 3 0 0 3 3 3 0 Inner spore coat protein D Fer4_8 PF13183.6 CDF32202.1 - 0.016 15.6 0.8 0.019 15.4 0.8 1.1 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDF32202.1 - 0.018 15.6 0.9 0.021 15.4 0.9 1.1 1 0 0 1 1 1 0 4Fe-4S dicluster domain Costars PF14705.6 CDF32203.1 - 3.1e-23 81.7 0.1 3.7e-23 81.5 0.1 1.1 1 0 0 1 1 1 1 Costars CPSF_A PF03178.15 CDF32204.1 - 1.9e-49 168.7 0.0 3.3e-48 164.7 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 CDF32204.1 - 5.9e-21 74.7 0.0 2.1e-11 43.2 0.4 2.3 2 0 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Pescadillo_N PF06732.11 CDF32204.1 - 0.28 10.7 5.7 0.48 9.9 5.7 1.3 1 0 0 1 1 1 0 Pescadillo N-terminus mRNA_triPase PF02940.15 CDF32205.1 - 7e-31 107.7 3.0 7e-31 107.7 3.0 1.4 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain Met_10 PF02475.16 CDF32206.1 - 3.2e-61 206.6 0.1 4.8e-61 206.0 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 CDF32206.1 - 1.2e-06 28.3 0.0 1.8e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MethyltransfD12 PF02086.15 CDF32206.1 - 0.00034 20.4 0.0 0.014 15.0 0.0 2.2 2 0 0 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase TRM PF02005.16 CDF32206.1 - 0.00044 19.5 0.0 0.00071 18.8 0.0 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MTS PF05175.14 CDF32206.1 - 0.0038 16.8 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDF32206.1 - 0.031 15.0 0.0 0.084 13.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 CDF32206.1 - 0.056 12.8 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CDF32206.1 - 0.093 12.5 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 CDF32206.1 - 0.094 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Cons_hypoth95 PF03602.15 CDF32206.1 - 0.14 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Histone PF00125.24 CDF32207.1 - 4.4e-53 179.1 1.6 4.9e-53 179.0 1.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDF32207.1 - 0.00012 22.7 1.4 0.00014 22.5 1.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDF32207.1 - 0.00013 22.0 0.4 0.00023 21.2 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDF32207.1 - 0.001 19.4 0.0 0.0016 18.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDF32207.1 - 0.01 16.1 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDF32207.1 - 0.086 12.9 0.2 0.16 12.1 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 CDF32208.1 - 1.9e-08 34.4 0.1 2.3e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDF32208.1 - 0.0018 18.6 0.1 0.0029 18.0 0.1 1.5 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 CDF32208.1 - 0.0061 16.7 0.1 0.0084 16.3 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDF32208.1 - 0.0078 16.6 0.1 0.0094 16.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF32208.1 - 0.012 15.9 0.0 0.018 15.3 0.0 1.4 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDF32208.1 - 0.071 13.2 0.0 0.083 13.0 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Pkinase PF00069.25 CDF32209.1 - 5.2e-76 255.5 0.0 7.1e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32209.1 - 2.2e-40 138.6 0.0 3e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF32209.1 - 1.7e-06 27.6 0.0 8.8e-06 25.2 0.0 2.1 3 0 0 3 3 3 1 Kinase-like AdenylateSensor PF16579.5 CDF32209.1 - 0.00071 20.0 0.0 0.0017 18.8 0.0 1.7 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase KA1 PF02149.19 CDF32209.1 - 0.0047 16.7 0.5 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 Kinase associated domain 1 Haspin_kinase PF12330.8 CDF32209.1 - 0.014 14.4 0.1 0.021 13.8 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain ABC1 PF03109.16 CDF32209.1 - 0.069 13.3 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Shikimate_DH PF01488.20 CDF32209.1 - 0.082 13.0 0.1 0.23 11.5 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase APH PF01636.23 CDF32209.1 - 0.14 12.1 0.7 0.42 10.5 0.0 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family PheRS_DBD3 PF18553.1 CDF32209.1 - 0.17 12.2 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 PheRS DNA binding domain 3 Choline_kinase PF01633.20 CDF32209.1 - 0.2 11.2 0.3 0.32 10.6 0.3 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase LRR_8 PF13855.6 CDF32210.1 - 7.8e-09 35.2 5.2 3.5e-07 29.9 1.0 2.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 CDF32210.1 - 2.8e-07 30.7 2.8 0.0041 17.5 0.0 3.3 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDF32210.1 - 1.9 9.3 4.1 1.2e+02 3.9 0.1 4.0 4 1 0 4 4 4 0 Leucine Rich Repeat DUF3580 PF12117.8 CDF32211.1 - 0.086 13.1 0.1 0.32 11.2 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3580) Glyco_hydro_85 PF03644.13 CDF32212.1 - 2e-83 280.3 0.0 2.6e-83 279.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 rve PF00665.26 CDF32213.1 - 1.6e-22 79.9 0.0 4.4e-22 78.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 CDF32213.1 - 1.1e-10 41.2 0.0 1.9e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF32213.1 - 2e-05 24.3 0.0 0.00014 21.6 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain DIMCO_N PF16844.5 CDF32213.1 - 0.067 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor, N-terminal FUN14 PF04930.15 CDF32215.1 - 6.7e-14 52.1 0.1 1.3e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 FUN14 family W2 PF02020.18 CDF32216.1 - 3.9e-07 30.1 0.1 1.3e-06 28.4 0.1 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 CDF32216.1 - 3.9e-06 26.4 10.3 0.0019 17.9 3.0 4.5 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 CDF32216.1 - 1.8e-05 23.9 0.1 3e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 CDF32216.1 - 0.036 12.2 0.2 0.057 11.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) RNase_H2_suC PF08615.11 CDF32216.1 - 0.13 12.5 0.3 4.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Hexapep_2 PF14602.6 CDF32216.1 - 3.1 7.6 6.4 4.6 7.1 2.5 2.7 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase PTPRCAP PF15713.5 CDF32216.1 - 5.2 7.4 13.3 1.5 9.1 0.7 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RNase_PH PF01138.21 CDF32218.1 - 8.4e-26 91.0 1.8 2.9e-15 57.0 0.0 3.2 3 0 0 3 3 3 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF32218.1 - 0.00022 21.2 0.1 0.0091 16.0 0.0 2.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Acatn PF13000.7 CDF32219.1 - 3.6e-20 72.0 3.2 1.9e-19 69.6 3.2 1.8 1 1 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Vac_ImportDeg PF09783.9 CDF32219.1 - 0.0065 16.3 0.0 0.012 15.4 0.0 1.9 1 1 0 1 1 1 1 Vacuolar import and degradation protein Acatn PF13000.7 CDF32220.1 - 1.8e-78 264.4 3.0 2.6e-77 260.6 3.0 1.9 1 1 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Creatinase_N PF01321.18 CDF32221.1 - 0.058 14.1 0.0 0.45 11.2 0.0 2.3 2 1 1 3 3 3 0 Creatinase/Prolidase N-terminal domain Syntaxin-6_N PF09177.11 CDF32224.1 - 0.072 13.6 0.1 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal WD40 PF00400.32 CDF32225.1 - 0.0011 19.7 2.4 0.0016 19.2 0.4 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF4094 PF13334.6 CDF32227.1 - 0.059 13.8 3.0 0.76 10.2 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) SBP_bac_3 PF00497.20 CDF32227.1 - 0.086 12.2 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 DUF2964 PF11177.8 CDF32227.1 - 1.2 9.4 4.0 3.4 7.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2964) Peptidase_S41 PF03572.18 CDF32230.1 - 2.3e-12 46.8 0.0 4.3e-12 45.9 0.0 1.4 1 1 0 1 1 1 1 Peptidase family S41 DUF4379 PF14311.6 CDF32232.1 - 0.069 13.5 2.3 0.17 12.3 2.3 1.7 1 0 0 1 1 1 0 Probable Zinc-ribbon domain Peptidase_S41 PF03572.18 CDF32233.1 - 1.8e-10 40.6 0.0 4.2e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase family S41 RtcB PF01139.17 CDF32234.1 - 1.3e-35 123.4 1.2 1.5e-35 123.2 1.2 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Cu-oxidase_4 PF02578.15 CDF32234.1 - 0.00031 20.4 1.0 0.00047 19.8 0.7 1.4 1 1 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase SipA PF09052.10 CDF32234.1 - 0.039 13.6 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 SipA N-terminal domain RtcB PF01139.17 CDF32235.1 - 7.2e-23 81.4 0.0 8e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DHQ_synthase PF01761.20 CDF32239.1 - 1.3e-08 34.3 0.0 2.1e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Methyltransf_3 PF01596.17 CDF32239.1 - 5.2e-08 32.3 0.0 9.3e-08 31.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase GidB PF02527.15 CDF32239.1 - 0.17 11.2 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PGAP1 PF07819.13 CDF32242.1 - 0.0052 16.5 0.0 0.0082 15.9 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein CPSF100_C PF13299.6 CDF32242.1 - 0.031 14.5 1.5 0.08 13.1 1.5 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Palm_thioest PF02089.15 CDF32242.1 - 0.2 11.5 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase GOLD_2 PF13897.6 CDF32242.1 - 0.3 11.6 1.2 0.81 10.2 1.2 1.7 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking CDC45 PF02724.14 CDF32242.1 - 0.95 7.7 9.7 1.4 7.1 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 CDF32242.1 - 1.9 7.7 18.7 3.1 7.0 18.7 1.2 1 0 0 1 1 1 0 BUD22 DUF2201_N PF13203.6 CDF32242.1 - 2.3 7.7 10.7 0.22 11.1 2.1 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain NOA36 PF06524.12 CDF32242.1 - 3 7.1 12.7 5.3 6.3 12.7 1.4 1 0 0 1 1 1 0 NOA36 protein DUF2052 PF09747.9 CDF32242.1 - 3.3 7.8 13.7 9.4 6.3 13.7 1.7 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Sporozoite_P67 PF05642.11 CDF32242.1 - 7.9 4.4 8.1 12 3.9 8.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cpn60_TCP1 PF00118.24 CDF32243.1 - 1.2e-146 489.2 13.5 1.4e-146 489.0 13.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TetR_C_14 PF17754.1 CDF32243.1 - 0.0028 17.6 0.2 0.009 16.0 0.2 1.9 1 0 0 1 1 1 1 MftR C-terminal domain GATA PF00320.27 CDF32244.1 - 3.2e-07 29.8 5.4 7.3e-07 28.7 5.4 1.6 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.18 CDF32244.1 - 0.084 12.9 3.4 0.17 12.0 3.4 1.6 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf OrfB_Zn_ribbon PF07282.11 CDF32244.1 - 0.095 12.6 4.6 0.054 13.4 2.2 1.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zn_Tnp_IS91 PF14319.6 CDF32244.1 - 0.44 10.6 3.7 2.3 8.3 3.8 2.1 1 1 1 2 2 2 0 Transposase zinc-binding domain Zn-ribbon_8 PF09723.10 CDF32244.1 - 0.49 10.6 2.6 1.7 8.9 0.4 2.7 3 0 0 3 3 3 0 Zinc ribbon domain An_peroxidase PF03098.15 CDF32245.1 - 5.2e-118 394.9 0.0 7.3e-118 394.4 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase UPF0160 PF03690.13 CDF32246.1 - 6.4e-102 341.4 0.0 4e-54 184.4 0.0 2.0 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0160) Acetyltransf_3 PF13302.7 CDF32247.1 - 2.7e-23 83.1 0.1 4e-23 82.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CDF32247.1 - 1e-05 25.3 1.8 3.1e-05 23.7 1.8 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDF32247.1 - 5.5e-05 23.4 0.0 7.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Pentapeptide PF00805.22 CDF32248.1 - 3e-18 65.1 13.4 7.8e-12 44.6 4.0 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 CDF32248.1 - 2.8e-11 43.4 15.3 6.4e-07 29.4 3.7 2.5 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 CDF32248.1 - 4.6e-09 36.3 0.3 4.6e-09 36.3 0.3 1.5 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) PsbQ PF05757.11 CDF32248.1 - 9.8e-05 22.2 0.8 0.00014 21.7 0.8 1.1 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) MGC-24 PF05283.11 CDF32248.1 - 0.33 11.4 1.4 2.1 8.8 0.1 2.1 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin EF-hand_1 PF00036.32 CDF32250.1 - 4.1e-19 66.6 6.7 4.4e-06 25.9 0.5 3.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 CDF32250.1 - 2.8e-17 62.9 3.2 1.4e-11 44.7 1.5 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDF32250.1 - 8.4e-16 57.6 1.6 2.3e-12 46.6 0.7 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDF32250.1 - 1.9e-15 55.4 2.0 0.0001 21.9 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 CDF32250.1 - 5.6e-11 41.4 0.9 0.0037 16.7 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 CDF32250.1 - 5.6e-06 26.6 0.1 0.00038 20.7 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_11 PF08976.11 CDF32250.1 - 0.00023 22.0 0.1 0.064 14.1 0.1 2.2 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 CDF32250.1 - 0.0039 17.3 0.4 0.018 15.2 0.4 2.0 1 1 1 2 2 2 1 Dockerin type I domain EF-hand_4 PF12763.7 CDF32250.1 - 0.017 15.1 1.2 0.21 11.5 0.7 2.5 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDF32250.1 - 0.025 14.9 0.2 0.34 11.3 0.2 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_2 PF13623.6 CDF32250.1 - 0.036 13.9 1.5 0.1 12.5 1.1 1.9 1 1 1 2 2 2 0 SurA N-terminal domain MgtE_N PF03448.17 CDF32250.1 - 0.04 14.5 1.7 0.083 13.5 1.7 1.5 1 0 0 1 1 1 0 MgtE intracellular N domain SUB1_ProdP9 PF18213.1 CDF32250.1 - 0.056 13.3 0.4 0.1 12.4 0.4 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 SurA_N_3 PF13624.6 CDF32250.1 - 0.11 12.3 1.7 0.18 11.5 1.4 1.5 1 1 0 1 1 1 0 SurA N-terminal domain DUF4440 PF14534.6 CDF32250.1 - 0.12 12.8 0.7 0.38 11.2 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) Peptidase_M24 PF00557.24 CDF32250.1 - 0.19 11.4 0.2 0.45 10.2 0.1 1.6 2 0 0 2 2 2 0 Metallopeptidase family M24 Pkinase PF00069.25 CDF32251.1 - 4.4e-18 65.6 0.0 5.6e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32251.1 - 1.6e-09 37.5 0.0 2.5e-09 36.8 0.0 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF32251.1 - 0.0015 18.5 0.9 0.0015 18.5 0.9 2.7 1 1 2 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF32251.1 - 0.0018 17.7 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDF32251.1 - 0.025 14.2 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DSX_dimer PF08828.10 CDF32253.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Doublesex dimerisation domain NAD_binding_2 PF03446.15 CDF32254.1 - 3.7e-34 118.2 0.1 8.4e-34 117.0 0.1 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CDF32254.1 - 2.7e-13 50.2 0.6 4.9e-13 49.4 0.6 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 CDF32254.1 - 3.9e-07 30.2 0.1 1.2e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CDF32254.1 - 0.00052 20.5 0.0 0.00096 19.7 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CDF32254.1 - 0.002 17.5 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDF32254.1 - 0.24 11.0 1.3 7.2 6.1 0.2 2.4 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SprT-like PF10263.9 CDF32259.1 - 7.5e-23 80.5 0.0 1.2e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 CDF32259.1 - 2.8e-06 27.1 4.7 7.4e-06 25.8 4.7 1.8 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 CDF32259.1 - 0.0011 19.0 0.6 0.0032 17.5 0.6 1.8 1 0 0 1 1 1 1 Zinc ribbon domain Peptidase_M50B PF13398.6 CDF32259.1 - 0.085 12.5 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase M50B-like SEP PF08059.13 CDF32260.1 - 3.8e-23 81.8 0.5 8e-23 80.8 0.0 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 CDF32260.1 - 1.8e-17 63.3 0.0 2.8e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 CDF32260.1 - 6.7e-13 48.2 0.4 1.7e-12 47.0 0.4 1.6 1 0 0 1 1 1 1 UBA-like domain Methyltr_RsmB-F PF01189.17 CDF32262.1 - 1.3e-66 224.0 0.0 2.2e-66 223.3 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CDF32262.1 - 4.3e-09 36.8 0.0 1.1e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 CDF32262.1 - 0.0098 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Phage_holin_2_4 PF16082.5 CDF32262.1 - 0.34 10.7 0.0 0.34 10.7 0.0 2.4 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like FAD_binding_1 PF00667.20 CDF32263.1 - 4.1e-29 101.7 0.0 8.9e-29 100.6 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 CDF32263.1 - 4.1e-27 95.2 0.0 2.1e-26 92.8 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 CDF32263.1 - 1.8e-15 57.5 0.0 5.7e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain SIS_2 PF13580.6 CDF32263.1 - 0.0033 17.5 0.4 0.0098 15.9 0.1 1.9 2 0 0 2 2 2 1 SIS domain Flavodoxin_5 PF12724.7 CDF32263.1 - 0.1 12.8 0.0 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 Flavodoxin domain Flavodoxin_3 PF12641.7 CDF32263.1 - 0.14 11.8 0.0 0.34 10.6 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain HTH_8 PF02954.19 CDF32264.1 - 0.013 15.3 0.1 4.9 7.0 0.0 3.6 3 1 0 3 3 3 0 Bacterial regulatory protein, Fis family HTH_50 PF18024.1 CDF32264.1 - 0.035 13.7 1.1 22 4.7 0.1 3.5 3 0 0 3 3 3 0 Helix-turn-helix domain ARID PF01388.21 CDF32264.1 - 0.045 14.4 0.0 0.94 10.2 0.0 2.9 2 2 0 2 2 2 0 ARID/BRIGHT DNA binding domain HTH_1 PF00126.27 CDF32264.1 - 0.058 13.3 0.3 14 5.8 0.0 3.3 3 0 0 3 3 3 0 Bacterial regulatory helix-turn-helix protein, lysR family Bud13 PF09736.9 CDF32265.1 - 1.8e-12 47.9 0.1 2.9e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex Paf1 PF03985.13 CDF32267.1 - 5.6e-21 75.0 5.6 1.1e-20 74.0 5.6 1.4 1 1 0 1 1 1 1 Paf1 rRNA_proc-arch PF13234.6 CDF32268.1 - 7.9e-62 209.6 0.0 1.7e-61 208.5 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 CDF32268.1 - 1.5e-47 161.3 0.2 3.9e-47 160.0 0.2 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CDF32268.1 - 5.5e-20 71.9 1.5 8.3e-20 71.3 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF32268.1 - 1.9e-06 28.0 0.0 4.2e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDF32268.1 - 1.1e-05 25.7 0.0 4.7e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain TSC22 PF01166.18 CDF32268.1 - 0.081 13.2 0.1 0.35 11.2 0.1 2.1 1 0 0 1 1 1 0 TSC-22/dip/bun family PfkB PF00294.24 CDF32269.1 - 1.2e-16 60.9 0.2 1.4e-16 60.7 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF5632 PF18646.1 CDF32269.1 - 0.023 14.7 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5632) GRIM-19 PF06212.12 CDF32270.1 - 2.3e-36 124.7 0.2 2.7e-36 124.5 0.2 1.0 1 0 0 1 1 1 1 GRIM-19 protein zf-C2H2 PF00096.26 CDF32272.1 - 2.4e-35 119.0 54.0 7.6e-06 26.1 1.3 9.5 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF32272.1 - 2.2e-28 97.4 43.7 4.8e-05 23.6 0.4 10.6 10 0 0 10 10 10 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF32272.1 - 1.4e-27 93.9 52.7 0.00011 22.7 0.7 9.6 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CDF32272.1 - 1.4e-13 51.0 22.2 5.3e-06 26.6 4.3 3.8 2 2 1 3 3 3 3 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 CDF32272.1 - 5.7e-06 26.2 45.9 0.00081 19.3 0.1 8.5 9 0 0 9 9 9 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDF32272.1 - 0.00021 21.5 23.0 0.19 12.1 0.1 8.5 9 0 0 9 9 9 1 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 CDF32272.1 - 0.0052 16.9 0.9 0.0052 16.9 0.9 3.0 3 0 0 3 3 3 1 Aberrant zinc-finger zf-C2H2_11 PF16622.5 CDF32272.1 - 0.006 16.3 35.1 0.19 11.5 0.2 7.7 8 0 0 8 8 8 3 zinc-finger C2H2-type zf-met PF12874.7 CDF32272.1 - 0.0062 16.9 29.1 1 9.9 0.2 8.0 9 0 0 9 9 8 3 Zinc-finger of C2H2 type GATA PF00320.27 CDF32272.1 - 0.031 13.9 1.2 4.5 7.0 0.0 3.3 3 0 0 3 3 3 0 GATA zinc finger zf-LITAF-like PF10601.9 CDF32272.1 - 0.04 14.2 6.4 12 6.3 0.0 4.5 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain zf-Di19 PF05605.12 CDF32272.1 - 0.075 13.3 0.6 0.075 13.3 0.6 5.5 4 3 1 5 5 4 0 Drought induced 19 protein (Di19), zinc-binding ROS_MUCR PF05443.11 CDF32272.1 - 0.1 12.7 0.7 5.4 7.1 0.0 3.2 2 1 1 4 4 4 0 ROS/MUCR transcriptional regulator protein XPA_N PF01286.18 CDF32272.1 - 0.11 12.6 10.3 1.7 8.8 0.2 4.6 4 0 0 4 4 4 0 XPA protein N-terminal FOXP-CC PF16159.5 CDF32272.1 - 0.18 12.5 15.4 7.4 7.3 0.9 5.9 3 2 3 6 6 5 0 FOXP coiled-coil domain zf_UBZ PF18439.1 CDF32272.1 - 0.67 9.6 14.5 2.3 7.9 0.1 5.4 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-C2H2_9 PF16293.5 CDF32272.1 - 3 7.8 6.3 25 4.8 0.1 4.5 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) ParA PF10609.9 CDF32273.1 - 3.8e-95 318.0 0.0 4.4e-95 317.8 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDF32273.1 - 1.4e-11 44.6 0.0 9.3e-11 41.9 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDF32273.1 - 2e-06 27.9 0.1 8.2e-06 25.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CDF32273.1 - 5e-06 25.9 1.3 8.7e-05 21.8 0.4 2.4 1 1 1 3 3 3 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 CDF32273.1 - 0.00069 19.6 0.5 0.0039 17.1 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase MipZ PF09140.11 CDF32273.1 - 0.0013 18.0 0.6 0.0049 16.2 0.6 1.8 1 1 0 1 1 1 1 ATPase MipZ AAA_25 PF13481.6 CDF32273.1 - 0.0035 17.0 0.2 0.0062 16.1 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF32273.1 - 0.009 16.4 0.3 0.015 15.7 0.3 1.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CDF32273.1 - 0.0099 15.1 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_26 PF13500.6 CDF32273.1 - 0.013 15.3 0.0 0.37 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain CBP_BcsQ PF06564.12 CDF32273.1 - 0.027 14.0 0.2 0.13 11.7 0.2 1.9 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 CDF32273.1 - 0.042 13.7 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Fer4_NifH PF00142.18 CDF32273.1 - 0.062 12.7 0.0 0.36 10.2 0.0 2.1 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_22 PF13401.6 CDF32273.1 - 0.094 13.0 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDF32273.1 - 0.13 12.2 0.1 0.21 11.5 0.1 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain UQ_con PF00179.26 CDF32274.1 - 2.3e-45 153.7 0.0 2.6e-45 153.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CDF32274.1 - 0.00018 21.3 0.0 0.00031 20.6 0.0 1.4 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 CDF32274.1 - 0.0063 16.2 0.0 0.0088 15.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDF32274.1 - 0.0064 16.8 0.0 0.0075 16.5 0.0 1.4 1 1 0 1 1 1 1 RWD domain Kinesin PF00225.23 CDF32275.1 - 2.1e-84 283.3 0.3 3.5e-84 282.6 0.3 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDF32275.1 - 5.3e-17 62.1 0.1 3.1e-16 59.6 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding AAA_9 PF12781.7 CDF32275.1 - 0.096 11.8 2.4 0.61 9.2 0.0 2.4 2 0 0 2 2 2 0 ATP-binding dynein motor region ParA PF10609.9 CDF32276.1 - 1.2e-85 286.8 0.3 1.8e-85 286.4 0.3 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase DUF971 PF06155.12 CDF32276.1 - 2.6e-14 53.6 0.0 5.6e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) FeS_assembly_P PF01883.19 CDF32276.1 - 5.8e-13 48.8 0.0 1.5e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 CDF32276.1 - 2.1e-12 47.2 0.0 3.4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDF32276.1 - 7.7e-11 42.2 1.0 5.6e-09 36.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 CDF32276.1 - 1.7e-10 40.6 0.0 2.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ VirC1 PF07015.11 CDF32276.1 - 0.0001 21.7 0.0 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 VirC1 protein Fer4_NifH PF00142.18 CDF32276.1 - 0.0017 17.9 0.1 0.0061 16.0 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 CDF32276.1 - 0.0018 17.5 1.7 0.061 12.5 0.4 2.6 2 1 0 2 2 2 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 CDF32276.1 - 0.036 13.5 0.2 1.8 8.0 0.2 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 CDF32276.1 - 0.063 12.2 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 CDF32276.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Radial_spoke_3 PF06098.11 CDF32279.1 - 0.099 11.9 0.4 0.11 11.8 0.4 1.0 1 0 0 1 1 1 0 Radial spoke protein 3 Spt20 PF12090.8 CDF32279.1 - 0.11 12.1 2.1 0.13 11.9 2.1 1.0 1 0 0 1 1 1 0 Spt20 family Tic22 PF04278.12 CDF32280.1 - 3.2e-29 102.1 0.7 6.1e-17 61.8 0.1 3.2 3 0 0 3 3 3 2 Tic22-like family TPR_1 PF00515.28 CDF32280.1 - 2.6e-11 42.8 2.1 7.5e-05 22.4 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF32280.1 - 1.4e-10 40.5 9.5 0.00057 19.8 0.5 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF32280.1 - 8.1e-08 31.8 0.1 0.00027 20.6 0.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_19 PF14559.6 CDF32280.1 - 0.0011 19.4 3.3 0.079 13.5 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF32280.1 - 0.0013 18.8 7.8 0.056 13.7 0.4 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDF32280.1 - 0.0027 17.8 1.6 1 9.5 0.5 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF32280.1 - 0.0055 17.4 6.5 0.51 11.3 0.0 3.8 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF32280.1 - 0.011 15.7 0.9 1.3 9.2 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF32280.1 - 0.013 15.7 0.4 0.23 11.7 0.7 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CDF32280.1 - 0.018 15.7 0.3 0.018 15.7 0.3 3.6 3 1 0 4 4 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF32280.1 - 0.023 15.0 5.0 0.65 10.3 0.8 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDF32280.1 - 0.096 13.1 0.6 0.39 11.2 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_lid_5 PF17865.1 CDF32280.1 - 0.17 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 Midasin AAA lid domain DUF3856 PF12968.7 CDF32280.1 - 0.4 10.7 5.2 4.7 7.3 0.9 3.1 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) K_channel_TID PF07941.11 CDF32280.1 - 1.1 9.8 8.3 4.4 7.8 1.4 2.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Na_K-ATPase PF00287.18 CDF32281.1 - 0.0028 16.9 0.0 0.0034 16.6 0.0 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Kinesin PF00225.23 CDF32282.1 - 1.5e-109 365.9 0.0 5.3e-109 364.2 0.0 1.9 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDF32282.1 - 4.5e-24 85.1 0.0 1.7e-23 83.2 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding BAG6 PF12057.8 CDF32282.1 - 0.14 11.9 1.3 0.27 10.9 0.2 2.0 2 0 0 2 2 2 0 BCL2-associated athanogene 6 TIR-like PF10137.9 CDF32282.1 - 0.15 12.1 0.8 25 4.8 0.1 3.0 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain KxDL PF10241.9 CDF32282.1 - 4.6 7.6 20.7 0.24 11.7 8.2 3.8 3 1 0 3 3 3 0 Uncharacterized conserved protein PUL PF08324.11 CDF32283.1 - 1.2e-37 129.7 0.1 1.8e-37 129.1 0.1 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 CDF32283.1 - 4e-35 119.2 7.6 5.2e-07 30.3 0.0 7.2 6 1 0 6 6 6 5 WD domain, G-beta repeat PFU PF09070.11 CDF32283.1 - 1.1e-33 115.8 0.4 2.6e-33 114.7 0.4 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) Nup160 PF11715.8 CDF32283.1 - 0.0011 17.7 3.3 0.027 13.2 0.2 3.3 3 1 1 4 4 4 1 Nucleoporin Nup120/160 Reoviridae_Vp9 PF08978.10 CDF32283.1 - 0.024 13.8 0.1 0.04 13.1 0.1 1.2 1 0 0 1 1 1 0 Reoviridae VP9 HTH_Tnp_Tc3_1 PF11427.8 CDF32284.1 - 1.1e-08 34.8 0.0 1.9e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF32284.1 - 1.9e-05 24.3 0.3 0.00012 21.7 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDF32284.1 - 0.0082 16.4 0.3 0.029 14.6 0.1 1.9 2 0 0 2 2 2 1 Transposase DUF4599 PF15371.6 CDF32284.1 - 0.023 15.2 0.4 0.038 14.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4599) HTH_32 PF13565.6 CDF32284.1 - 0.071 13.7 1.1 0.16 12.6 0.9 1.8 1 1 0 1 1 1 0 Homeodomain-like domain DDE_3 PF13358.6 CDF32285.1 - 1.7e-09 37.6 0.0 2.5e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease GKAP PF03359.13 CDF32285.1 - 0.065 12.8 0.0 0.07 12.7 0.0 1.0 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein HHH_2 PF12826.7 CDF32285.1 - 0.21 11.7 0.0 13 5.9 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif Linker_histone PF00538.19 CDF32286.1 - 1.4e-18 67.1 1.1 1.4e-18 67.1 1.1 2.4 2 1 0 2 2 2 1 linker histone H1 and H5 family CDC27 PF09507.10 CDF32286.1 - 0.043 13.2 20.5 0.042 13.3 20.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF1631 PF07793.11 CDF32286.1 - 0.1 11.0 5.5 0.13 10.7 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Cellulose_synt PF03552.14 CDF32287.1 - 1.6e-17 63.4 16.2 4.4e-07 28.8 0.2 4.8 3 1 1 4 4 4 3 Cellulose synthase Glyco_trans_2_3 PF13632.6 CDF32287.1 - 4.1e-15 56.2 9.7 1.8e-14 54.1 4.4 3.2 1 1 1 2 2 2 1 Glycosyl transferase family group 2 AMPK1_CBM PF16561.5 CDF32287.1 - 2.6e-13 50.0 0.3 6.6e-13 48.7 0.0 1.8 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase Glyco_tranf_2_3 PF13641.6 CDF32287.1 - 2.1e-12 47.5 0.2 2.4e-11 44.0 0.1 2.5 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDF32287.1 - 2e-11 44.0 0.8 4.7e-08 33.0 0.3 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CDF32287.1 - 9.4e-07 28.5 0.6 0.0011 18.5 0.1 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 21 PerB PF06590.11 CDF32287.1 - 0.057 13.9 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 PerB protein p450 PF00067.22 CDF32288.1 - 5.7e-48 163.8 0.0 7.5e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CDF32290.1 - 1.2e-46 159.2 0.0 1.4e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32290.1 - 1.7e-20 73.4 0.1 2.3e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF32290.1 - 1.1e-06 28.3 0.0 6.2e-06 25.7 0.0 1.9 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 CDF32290.1 - 0.00022 20.9 0.2 0.0012 18.5 0.2 2.0 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.14 CDF32290.1 - 0.00081 18.8 0.1 0.0012 18.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family BAH PF01426.18 CDF32292.1 - 2e-08 34.1 0.5 2.7e-08 33.7 0.5 1.2 1 0 0 1 1 1 1 BAH domain WHAMM-JMY_N PF15920.5 CDF32292.1 - 0.088 12.7 0.3 0.21 11.5 0.3 1.6 1 0 0 1 1 1 0 N-terminal of Junction-mediating and WASP homolog-associated Peptidase_U32_C PF16325.5 CDF32292.1 - 0.12 12.7 0.0 9.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain CactinC_cactus PF09732.9 CDF32294.1 - 7.1e-56 187.5 6.8 1.1e-55 186.9 6.8 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 CDF32294.1 - 4.4e-28 98.4 2.4 4.4e-28 98.4 2.4 1.9 2 0 0 2 2 2 1 Conserved mid region of cactin IKI3 PF04762.12 CDF32295.1 - 5.5e-122 408.6 0.0 2.4e-82 277.4 0.0 3.1 1 1 2 3 3 3 3 IKI3 family Dishevelled PF02377.15 CDF32295.1 - 0.14 12.6 3.4 0.26 11.7 3.4 1.3 1 0 0 1 1 1 0 Dishevelled specific domain CAF1A PF12253.8 CDF32296.1 - 2.1e-17 63.0 0.8 2.1e-17 63.0 0.8 2.8 3 0 0 3 3 3 1 Chromatin assembly factor 1 subunit A Fic PF02661.18 CDF32296.1 - 0.13 13.2 0.0 0.38 11.7 0.0 1.9 1 0 0 1 1 1 0 Fic/DOC family Exonuc_VII_L PF02601.15 CDF32296.1 - 0.7 9.4 10.0 0.067 12.8 5.3 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit GDC-P PF02347.16 CDF32298.1 - 9.9e-90 301.4 0.1 1.1e-89 301.3 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein tRNA_Me_trans PF03054.16 CDF32300.1 - 1.2e-90 303.9 0.0 1.4e-90 303.7 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 CDF32300.1 - 0.0077 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.17 CDF32300.1 - 0.033 13.3 0.0 0.42 9.7 0.0 2.0 2 0 0 2 2 2 0 NAD synthase Asn_synthase PF00733.21 CDF32300.1 - 0.074 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase RHD3 PF05879.12 CDF32301.1 - 7.2e-31 107.1 0.4 1e-30 106.6 0.4 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Exo_endo_phos PF03372.23 CDF32302.1 - 4.9e-09 36.1 0.1 8.3e-09 35.3 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_L3 PF00297.22 CDF32303.1 - 1.8e-182 606.4 9.0 2e-182 606.2 9.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Big_3_3 PF13750.6 CDF32303.1 - 0.16 11.6 0.0 0.51 10.0 0.0 1.8 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 3) Pkinase PF00069.25 CDF32305.1 - 4.1e-68 229.6 0.0 5.4e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32305.1 - 8.3e-36 123.6 0.0 1.2e-35 123.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF32305.1 - 8.5e-06 25.9 0.6 0.084 12.8 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF32305.1 - 0.00025 20.4 0.0 0.00046 19.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDF32305.1 - 0.0049 15.7 0.0 0.012 14.5 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDF32305.1 - 0.069 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SOUL PF04832.12 CDF32306.1 - 3.1e-37 128.3 0.0 6.2e-37 127.4 0.0 1.5 1 0 0 1 1 1 1 SOUL heme-binding protein HCO3_cotransp PF00955.21 CDF32307.1 - 2e-145 485.5 14.9 1e-86 291.8 3.4 2.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.13 CDF32307.1 - 5.9e-05 23.0 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.22 CDF32307.1 - 0.028 14.3 0.0 0.071 13.0 0.0 1.7 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 LOR PF04525.12 CDF32308.1 - 1.9e-16 60.2 0.0 2.6e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 LURP-one-related TFIIA PF03153.13 CDF32308.1 - 1.6 8.6 5.5 2 8.3 5.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RIIa PF02197.17 CDF32310.1 - 0.15 11.7 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Tcf25 PF04910.14 CDF32311.1 - 1.4e-64 218.4 0.0 1.9e-64 218.0 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_7 PF13176.6 CDF32311.1 - 0.00067 19.5 3.8 0.0021 17.9 0.6 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF32311.1 - 0.0061 16.7 0.0 0.04 14.1 0.1 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDF32311.1 - 0.0093 15.8 2.3 0.073 13.0 0.4 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat AP3D1 PF06375.11 CDF32311.1 - 0.013 15.7 4.6 0.026 14.8 4.6 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TPR_17 PF13431.6 CDF32311.1 - 0.024 15.0 0.1 0.2 12.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF32311.1 - 0.03 14.2 0.1 0.11 12.4 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF32311.1 - 0.12 12.7 0.3 0.12 12.7 0.3 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF32311.1 - 0.13 12.8 4.3 0.33 11.5 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF32311.1 - 0.2 11.9 2.1 0.3 11.3 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3381 PF11861.8 CDF32311.1 - 0.3 10.9 8.6 0.96 9.2 8.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) TPR_14 PF13428.6 CDF32311.1 - 0.75 10.8 12.3 0.14 13.1 0.6 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF32311.1 - 4.9 8.0 9.7 0.55 11.0 0.7 4.2 6 0 0 6 6 5 0 Tetratricopeptide repeat SPT6_acidic PF14632.6 CDF32311.1 - 6.3 7.5 15.0 23 5.7 15.0 2.0 1 1 0 1 1 1 0 Acidic N-terminal SPT6 SPO22 PF08631.10 CDF32312.1 - 3.9e-17 62.6 11.1 3.3e-14 53.1 0.1 4.2 5 1 0 5 5 5 2 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 CDF32312.1 - 4.7e-06 26.8 16.0 0.0018 18.5 0.1 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF32312.1 - 0.022 15.3 9.2 9 6.9 0.0 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF32312.1 - 1.6 9.0 5.0 4.1 7.7 0.4 4.0 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 CDF32312.1 - 7.9 6.5 7.3 82 3.3 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDF32312.1 - 8.6 7.3 6.8 82 4.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat EPSP_synthase PF00275.20 CDF32313.1 - 0.031 13.0 0.0 0.044 12.5 0.0 1.3 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Sel1 PF08238.12 CDF32314.1 - 2.1e-63 209.3 14.2 5.8e-07 30.0 0.0 11.1 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.6 CDF32314.1 - 2.7e-18 65.3 19.5 0.09 13.5 0.0 11.8 10 2 1 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF32314.1 - 2e-11 44.3 36.0 0.16 12.6 0.1 9.5 5 4 5 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDF32314.1 - 3.9e-11 42.5 5.3 0.84 10.2 0.2 10.0 9 4 0 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF32314.1 - 3.1e-09 36.2 25.5 2.8 8.2 0.0 10.5 8 2 2 10 10 10 4 Tetratricopeptide repeat MIT PF04212.18 CDF32314.1 - 5e-06 26.5 9.9 18 5.5 0.0 7.8 8 0 0 8 8 8 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 CDF32314.1 - 1.3e-05 25.6 34.4 20 6.3 0.1 10.7 6 4 5 11 11 11 0 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF32314.1 - 0.00012 22.2 4.8 8.3 6.8 0.0 5.3 4 2 2 6 6 5 1 Arginine decarboxylase helical bundle domain NSF PF02071.20 CDF32314.1 - 0.00016 21.7 12.5 1.5e+02 3.9 0.1 9.4 10 0 0 10 10 9 0 Aromatic-di-Alanine (AdAR) repeat Exonuc_VII_S PF02609.16 CDF32314.1 - 0.00058 19.9 6.7 5.7 7.1 0.0 6.7 9 0 0 9 9 8 2 Exonuclease VII small subunit SNAP PF14938.6 CDF32314.1 - 0.0047 16.4 5.5 0.005 16.3 0.5 3.1 3 1 1 4 4 4 2 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 CDF32314.1 - 0.0059 16.4 17.6 2.6 8.0 0.0 8.4 9 0 0 9 9 8 1 Tetratricopeptide repeat HEPN_Apea PF18739.1 CDF32314.1 - 0.034 14.6 0.3 1.4e+02 3.0 0.0 5.2 5 1 1 6 6 6 0 Apea-like HEPN HTH_Bact PF18768.1 CDF32314.1 - 0.059 13.0 0.0 39 3.9 0.0 3.8 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain TPR_11 PF13414.6 CDF32314.1 - 0.16 11.7 10.2 56 3.5 0.0 6.7 7 0 0 7 7 7 0 TPR repeat TPR_2 PF07719.17 CDF32314.1 - 0.61 10.3 33.7 14 6.1 0.0 10.6 12 0 0 12 12 11 0 Tetratricopeptide repeat FtsX PF02687.21 CDF32315.1 - 2e-12 47.4 16.7 2.2e-11 44.1 2.6 4.8 4 1 1 5 5 5 2 FtsX-like permease family AcrZ PF10766.9 CDF32315.1 - 7.1 6.3 7.8 1.7 8.3 1.4 2.9 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ ABC_tran_Xtn PF12848.7 CDF32316.1 - 0.35 10.9 7.0 58 3.8 7.8 2.8 2 0 0 2 2 2 0 ABC transporter GDP_Man_Dehyd PF16363.5 CDF32317.1 - 3e-58 197.8 0.0 9.9e-58 196.1 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDF32317.1 - 3.7e-50 170.6 0.0 4.6e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CDF32317.1 - 7.4e-13 48.3 0.0 2e-07 30.5 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 CDF32317.1 - 4.8e-11 42.2 0.0 7.1e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDF32317.1 - 2e-10 40.3 0.2 3.9e-06 26.2 0.1 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDF32317.1 - 6.2e-08 32.1 0.0 9e-08 31.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CDF32317.1 - 3.6e-05 23.3 0.0 0.00011 21.7 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CDF32317.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 KR domain NAD_binding_10 PF13460.6 CDF32317.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.4 1 1 0 1 1 1 0 NAD(P)H-binding NAD_binding_7 PF13241.6 CDF32317.1 - 0.069 13.6 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding NmrA PF05368.13 CDF32317.1 - 0.17 11.4 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family KH_6 PF15985.5 CDF32318.1 - 4.6e-07 30.1 0.0 8.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 CDF32318.1 - 0.0016 19.0 0.0 0.076 13.6 0.0 2.3 1 1 1 2 2 2 1 Exosome component EXOSC1/CSL4 Aminotran_5 PF00266.19 CDF32320.1 - 1.5e-49 168.9 0.0 1.9e-49 168.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V S1-like PF14444.6 CDF32320.1 - 0.036 14.0 0.0 0.092 12.7 0.0 1.6 1 0 0 1 1 1 0 S1-like DnaJ_CXXCXGXG PF00684.19 CDF32322.1 - 0.0074 16.6 9.5 0.43 11.0 10.7 2.4 1 1 1 2 2 2 2 DnaJ central domain MAT1 PF06391.13 CDF32322.1 - 0.039 13.8 7.9 0.086 12.7 7.9 1.5 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Tn7_Tnp_TnsA_N PF08722.11 CDF32322.1 - 6.9 6.9 6.9 6.1 7.1 2.3 2.7 3 0 0 3 3 3 0 TnsA endonuclease N terminal TMEM208_SND2 PF05620.11 CDF32324.1 - 1.4e-36 125.8 0.2 1.7e-36 125.6 0.2 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 YlaC PF10777.9 CDF32324.1 - 0.27 11.1 1.9 2.1 8.2 0.1 2.1 2 0 0 2 2 2 0 Inner membrane protein YlaC Peptidase_M56 PF05569.11 CDF32324.1 - 0.4 9.8 5.2 0.83 8.8 5.2 1.6 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF3730 PF12530.8 CDF32326.1 - 2e-06 27.5 1.6 3.9e-06 26.6 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3730) HEAT PF02985.22 CDF32326.1 - 0.00019 21.4 0.2 0.022 15.0 0.0 4.0 2 0 0 2 2 2 1 HEAT repeat HEAT_EZ PF13513.6 CDF32326.1 - 0.00028 21.3 4.4 0.015 15.8 0.0 4.1 3 0 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.6 CDF32326.1 - 0.00085 19.7 7.6 0.11 13.0 0.0 4.0 3 1 0 3 3 3 2 HEAT repeats Adaptin_N PF01602.20 CDF32326.1 - 0.042 12.4 0.3 0.087 11.4 0.0 1.6 2 0 0 2 2 2 0 Adaptin N terminal region Adaptin_binding PF10199.9 CDF32326.1 - 0.12 13.0 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 HEAT_PBS PF03130.16 CDF32326.1 - 0.17 12.6 4.1 9.8 7.2 0.2 4.8 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Sirohm_synth_C PF14823.6 CDF32326.1 - 0.24 11.1 0.8 25 4.6 0.0 2.9 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal PMSR PF01625.21 CDF32329.1 - 1.6e-52 177.7 1.0 2.5e-52 177.1 1.0 1.2 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase FKBP_C PF00254.28 CDF32329.1 - 9.9e-22 77.1 0.1 2.4e-21 75.8 0.0 1.7 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase ART PF01129.18 CDF32329.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase ERG2_Sigma1R PF04622.12 CDF32330.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 ERG2 and Sigma1 receptor like protein ArfGap PF01412.18 CDF32334.1 - 5.8e-33 113.4 0.2 1.3e-32 112.3 0.2 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase PF00069.25 CDF32336.1 - 2.3e-73 246.8 0.0 3.2e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32336.1 - 2.1e-41 142.0 0.0 3e-41 141.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF32336.1 - 4.6e-07 29.0 0.0 8.7e-07 28.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDF32336.1 - 2.1e-06 27.2 0.1 4e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF32336.1 - 0.0019 18.1 0.0 0.03 14.2 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF32336.1 - 0.0078 15.8 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 CDF32336.1 - 0.024 13.9 0.0 0.1 11.9 0.0 1.9 1 1 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.11 CDF32336.1 - 0.12 11.3 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PH PF00169.29 CDF32336.1 - 0.13 12.8 0.0 0.35 11.4 0.0 1.8 1 1 0 1 1 1 0 PH domain AAA_12 PF13087.6 CDF32339.1 - 2.7e-21 76.1 0.0 4.8e-21 75.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain zf-CCCH PF00642.24 CDF32339.1 - 1.1e-09 37.9 12.7 6.1e-05 22.8 4.5 3.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_11 PF13086.6 CDF32339.1 - 2.1e-09 37.6 0.3 0.00097 19.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain zf-CCCH_4 PF18044.1 CDF32339.1 - 1.8e-06 27.6 13.6 0.0068 16.2 4.3 3.1 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 CDF32339.1 - 0.00012 22.7 9.7 0.0011 19.6 0.7 2.7 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 CDF32339.1 - 0.0058 16.7 20.1 0.035 14.2 4.5 3.0 2 0 0 2 2 2 2 Zinc finger domain AAA_30 PF13604.6 CDF32339.1 - 0.032 14.0 0.0 0.088 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDF32339.1 - 0.069 13.7 0.0 0.21 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Phage_holin_3_6 PF07332.11 CDF32339.1 - 1.4 9.0 4.8 0.49 10.5 0.4 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III OmpH PF03938.14 CDF32339.1 - 3.6 7.9 6.5 9.6 6.5 6.5 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DDE_3 PF13358.6 CDF32340.1 - 1.1e-12 47.9 0.4 1.7e-12 47.3 0.4 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF32341.1 - 2.1e-08 33.9 0.0 3.3e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF32341.1 - 3.2e-07 30.0 0.1 5.5e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF32341.1 - 1.1e-05 26.0 1.5 0.056 14.1 0.2 2.1 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 CDF32341.1 - 7.4e-05 22.4 0.1 0.00013 21.6 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 CDF32341.1 - 0.0045 17.0 0.4 0.019 14.9 0.2 2.1 1 1 1 2 2 2 1 Winged helix-turn helix Terminase_5 PF06056.12 CDF32341.1 - 0.013 15.4 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Ribosomal_S19e PF01090.19 CDF32341.1 - 0.018 14.8 0.3 0.035 13.8 0.3 1.6 1 1 0 1 1 1 0 Ribosomal protein S19e KorB PF08535.10 CDF32341.1 - 0.13 12.3 0.1 0.28 11.3 0.0 1.6 2 0 0 2 2 2 0 KorB domain rve PF00665.26 CDF32342.1 - 1.3e-09 38.2 0.0 2.4e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF32342.1 - 2.9e-06 27.3 0.1 4.2e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDF32342.1 - 0.18 12.0 0.0 0.42 10.9 0.0 1.7 1 0 0 1 1 1 0 H2C2 zinc finger Helicase_C PF00271.31 CDF32348.1 - 4.2e-15 56.1 0.0 1.1e-14 54.8 0.0 1.7 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CDF32348.1 - 1.5e-07 31.1 10.5 3.4e-07 30.0 10.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF32348.1 - 4.2e-07 29.7 9.8 9.6e-07 28.6 9.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF32348.1 - 5.4e-07 29.8 10.7 1.2e-06 28.7 10.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF32348.1 - 2.4e-06 27.3 9.2 5.1e-06 26.3 9.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 CDF32348.1 - 6.9e-05 21.7 0.0 0.00012 20.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CDF32348.1 - 9.5e-05 22.3 4.6 9.5e-05 22.3 4.6 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CDF32348.1 - 0.00096 18.9 9.8 0.0022 17.8 9.8 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 CDF32348.1 - 0.0034 17.3 12.0 0.018 15.0 12.2 2.1 1 1 1 2 2 2 1 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 CDF32348.1 - 0.046 12.9 0.0 0.076 12.2 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Prok-RING_4 PF14447.6 CDF32348.1 - 0.084 12.8 11.8 0.13 12.2 6.2 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDF32348.1 - 0.26 11.5 9.8 0.62 10.3 9.8 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 CDF32348.1 - 0.3 10.9 4.6 0.69 9.8 4.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 CDF32348.1 - 0.37 11.0 6.2 1.1 9.4 6.2 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 CDF32348.1 - 0.67 10.3 8.2 1.4 9.2 3.5 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 CDF32348.1 - 2.2 8.2 8.5 1.1 9.2 5.9 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein RAB3GAP2_N PF14655.6 CDF32349.1 - 0.0083 15.4 0.0 0.009 15.3 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Sel1 PF08238.12 CDF32355.1 - 8.7e-46 153.3 2.1 3.2e-06 27.6 0.0 8.5 8 0 0 8 8 8 7 Sel1 repeat TPR_6 PF13174.6 CDF32355.1 - 0.00013 22.4 5.9 0.86 10.4 0.0 5.9 6 1 0 6 6 6 1 Tetratricopeptide repeat CNTF PF01110.17 CDF32355.1 - 0.018 14.4 0.2 0.039 13.3 0.2 1.5 1 0 0 1 1 1 0 Ciliary neurotrophic factor TPR_7 PF13176.6 CDF32355.1 - 0.021 14.8 2.7 0.71 10.0 0.1 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat tRNA_U5-meth_tr PF05958.11 CDF32357.1 - 1.5e-23 83.4 0.1 1.1e-22 80.5 0.1 1.9 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 CDF32357.1 - 2.4e-14 53.4 0.3 3.2e-14 53.0 0.3 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF32357.1 - 1.6e-10 41.5 0.1 3.4e-10 40.5 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF32357.1 - 8.5e-09 35.2 0.2 1.3e-08 34.6 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDF32357.1 - 2.6e-06 27.2 0.0 3.2e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 N6_N4_Mtase PF01555.18 CDF32357.1 - 8.2e-06 25.7 0.0 1.1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_15 PF09445.10 CDF32357.1 - 8.6e-06 25.4 0.1 1.6e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 CDF32357.1 - 2.5e-05 24.9 0.1 5.6e-05 23.8 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDF32357.1 - 2.9e-05 23.6 1.8 3.8e-05 23.2 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 CDF32357.1 - 0.00013 21.5 0.1 0.00017 21.1 0.1 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 CDF32357.1 - 0.00021 21.3 0.6 0.00052 20.0 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF32357.1 - 0.00024 20.5 0.1 0.00036 19.9 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 CDF32357.1 - 0.00026 21.6 0.0 0.00051 20.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CDF32357.1 - 0.00065 19.4 1.5 0.016 14.9 1.5 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MethyltransfD12 PF02086.15 CDF32357.1 - 0.0012 18.6 0.1 0.033 13.9 0.0 2.0 1 1 1 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_23 PF13489.6 CDF32357.1 - 0.0014 18.5 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 CDF32357.1 - 0.0016 18.1 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Met_10 PF02475.16 CDF32357.1 - 0.0021 17.9 0.1 0.0033 17.2 0.1 1.4 1 1 0 1 1 1 1 Met-10+ like-protein RrnaAD PF00398.20 CDF32357.1 - 0.003 16.7 0.0 0.0043 16.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 CDF32357.1 - 0.0063 16.0 0.1 0.0086 15.6 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 CDF32357.1 - 0.0064 16.2 0.1 0.0095 15.7 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltrans_SAM PF10672.9 CDF32357.1 - 0.016 14.4 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase NodS PF05401.11 CDF32357.1 - 0.024 14.2 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) PCMT PF01135.19 CDF32357.1 - 0.026 14.3 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 CDF32357.1 - 0.12 11.9 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Pox_MCEL PF03291.16 CDF32357.1 - 0.16 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme GST_N_2 PF13409.6 CDF32358.1 - 2.4e-06 27.7 0.0 5.6e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDF32358.1 - 1.4e-05 25.4 0.0 4.5e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDF32358.1 - 8.2e-05 22.9 0.0 0.00018 21.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDF32358.1 - 0.059 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CCT PF06203.14 CDF32361.1 - 6.8e-11 42.0 5.8 6.8e-11 42.0 5.8 1.7 2 0 0 2 2 2 1 CCT motif Acyltransferase PF01553.21 CDF32362.1 - 1.4e-10 40.9 0.0 2.2e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase DDE_3 PF13358.6 CDF32363.1 - 2.2e-18 66.4 0.0 3.6e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF32363.1 - 1.1e-11 44.4 0.0 2.5e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF32363.1 - 3.3e-06 26.8 0.7 7.3e-06 25.6 0.7 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF32363.1 - 2.3e-05 24.9 0.6 0.15 12.7 0.0 2.6 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 CDF32363.1 - 0.0059 16.4 1.4 0.67 9.8 0.1 3.6 4 0 0 4 4 4 1 Homeodomain-like domain Ribosomal_L35Ae PF01247.18 CDF32364.1 - 5e-13 49.0 0.2 5.4e-13 48.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CDF32364.1 - 0.033 14.4 0.0 0.033 14.4 0.0 1.1 1 0 0 1 1 1 0 RimM N-terminal domain Ribosomal_L35Ae PF01247.18 CDF32365.1 - 0.00051 20.2 0.0 0.00059 19.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae SLT PF01464.20 CDF32366.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain Retrotran_gag_2 PF14223.6 CDF32368.1 - 1.2e-33 115.7 0.1 2.2e-33 114.8 0.1 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF32368.1 - 4.6e-20 72.0 0.0 9.4e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF32368.1 - 0.0015 18.3 0.2 0.011 15.6 0.0 2.4 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF32368.1 - 0.0033 17.1 0.0 0.0088 15.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF32368.1 - 0.077 12.7 1.5 0.23 11.2 1.5 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF32368.1 - 0.28 11.3 4.0 0.58 10.3 4.0 1.6 1 0 0 1 1 1 0 Zinc knuckle ST7 PF04184.12 CDF32370.1 - 0.19 10.1 0.0 0.29 9.5 0.0 1.1 1 0 0 1 1 1 0 ST7 protein Ribosomal_S21e PF01249.18 CDF32373.1 - 2.1e-38 130.3 0.0 2.3e-38 130.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e YjeF_N PF03853.15 CDF32374.1 - 3.7e-34 118.1 0.0 5e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus JAB PF01398.21 CDF32375.1 - 5.7e-28 97.3 0.1 1.1e-27 96.3 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 CDF32375.1 - 2.5e-15 57.2 0.5 4e-15 56.5 0.5 1.3 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 CDF32375.1 - 0.0004 20.1 0.0 0.00077 19.2 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CDF32375.1 - 0.076 13.1 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) SMP_LBD PF17047.5 CDF32378.1 - 4.1e-14 52.4 0.0 7.2e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 CDF32378.1 - 2.2e-11 43.9 0.0 2.7e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 C2 domain Pkinase PF00069.25 CDF32379.1 - 6.2e-70 235.6 0.0 7.8e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32379.1 - 1.3e-37 129.5 0.0 1.8e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF32379.1 - 7.7e-05 22.1 0.0 0.00028 20.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CDF32379.1 - 0.012 15.5 0.6 0.061 13.2 0.1 2.1 2 1 0 3 3 3 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF32379.1 - 0.052 13.1 0.1 0.083 12.5 0.1 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 CDF32379.1 - 0.11 11.4 0.1 0.17 10.8 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain GTP_EFTU PF00009.27 CDF32380.1 - 5.2e-37 127.3 0.0 1.2e-36 126.1 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDF32380.1 - 1.8e-15 57.2 0.1 3.4e-15 56.3 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 CDF32380.1 - 3.1e-06 27.3 0.0 6.2e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase HBS1_N PF08938.10 CDF32380.1 - 8.6e-06 26.0 3.3 1.8e-05 25.0 2.7 1.8 2 0 0 2 2 2 1 HBS1 N-terminus cobW PF02492.19 CDF32380.1 - 0.00069 19.3 0.7 0.67 9.5 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CDF32380.1 - 0.0088 16.0 0.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase ATP-synt_D PF01813.17 CDF32381.1 - 5.7e-64 215.6 0.2 5.7e-64 215.6 0.2 1.3 2 0 0 2 2 2 1 ATP synthase subunit D AAA_31 PF13614.6 CDF32381.1 - 0.044 13.7 0.1 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain HMG_CoA_synt_N PF01154.17 CDF32383.1 - 1.3e-78 262.9 0.0 2e-78 262.2 0.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 CDF32383.1 - 5.1e-77 259.2 0.0 6.8e-77 258.8 0.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III_C PF08541.10 CDF32383.1 - 0.01 16.0 0.0 0.025 14.7 0.0 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Dak2 PF02734.17 CDF32383.1 - 0.087 12.7 0.2 0.21 11.5 0.1 1.7 2 0 0 2 2 2 0 DAK2 domain WD40 PF00400.32 CDF32385.1 - 2.2e-09 37.8 27.2 0.00017 22.3 0.0 9.6 10 1 0 10 10 10 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32385.1 - 0.014 15.6 1.6 17 5.8 0.0 5.3 4 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain AAA_25 PF13481.6 CDF32385.1 - 0.039 13.5 0.8 0.45 10.1 0.1 3.0 3 1 1 4 4 4 0 AAA domain SPT2 PF08243.11 CDF32386.1 - 0.0095 16.5 25.6 0.0095 16.5 25.6 3.0 2 1 0 2 2 2 1 SPT2 chromatin protein TPR_10 PF13374.6 CDF32386.1 - 0.055 13.3 4.2 0.36 10.8 2.4 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4437 PF14499.6 CDF32386.1 - 0.14 11.2 1.7 3.5 6.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4437) DNA_pol3_a_NII PF11490.8 CDF32386.1 - 9.8 6.1 9.8 0.65 9.9 2.4 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II THUMP PF02926.17 CDF32387.1 - 9.6e-14 51.7 0.1 2e-13 50.7 0.1 1.6 1 0 0 1 1 1 1 THUMP domain tRNA_edit PF04073.15 CDF32388.1 - 1.8e-06 28.1 0.0 8.2e-06 25.9 0.0 1.9 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain DEAD PF00270.29 CDF32389.1 - 4.3e-39 134.1 0.0 6.4e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF32389.1 - 8.9e-24 84.0 0.0 3.8e-23 81.9 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF32389.1 - 6.9e-06 26.2 0.0 1.4e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDF32389.1 - 0.0087 16.3 0.1 0.035 14.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain Rhodanese PF00581.20 CDF32390.1 - 6.9e-18 65.1 0.0 5.5e-10 39.7 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain ASH PF15780.5 CDF32391.1 - 9.7e-05 22.5 4.2 0.036 14.3 0.0 5.5 6 0 0 6 6 6 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 CDF32391.1 - 0.0001 22.2 0.3 3.3 7.8 0.0 4.3 4 0 0 4 4 4 2 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 CDF32391.1 - 0.00075 19.7 3.6 27 5.1 0.0 5.8 7 0 0 7 7 7 1 Transmembrane protein 131-like fn3_5 PF06280.12 CDF32391.1 - 0.0018 19.0 1.4 13 6.5 0.0 5.1 6 0 0 6 6 6 1 Fn3-like domain PapD-like PF14874.6 CDF32391.1 - 0.0046 17.1 1.1 2.2 8.5 0.0 3.9 4 0 0 4 4 4 1 Flagellar-associated PapD-like Transglut_C PF00927.22 CDF32391.1 - 0.0069 16.5 1.8 3.5 7.8 0.2 4.3 5 1 1 6 6 6 1 Transglutaminase family, C-terminal ig like domain zf-RING_2 PF13639.6 CDF32392.1 - 4.8e-09 36.4 9.8 9.4e-09 35.5 9.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF32392.1 - 2.1e-06 27.9 5.7 4.6e-06 26.8 5.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDF32392.1 - 2.7e-06 27.0 8.1 2.7e-06 27.0 8.1 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF32392.1 - 5.3e-05 23.0 8.5 0.00011 21.9 8.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF32392.1 - 0.00049 19.9 8.2 0.00086 19.1 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF32392.1 - 0.0036 17.3 4.4 0.0083 16.1 4.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDF32392.1 - 0.0087 15.9 8.0 0.016 15.0 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF32392.1 - 0.0089 16.0 7.4 0.018 15.0 7.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDF32392.1 - 0.02 14.5 7.4 0.037 13.7 7.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDF32392.1 - 0.031 14.3 1.8 0.07 13.2 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H_2 PF13832.6 CDF32392.1 - 0.045 13.9 2.1 0.11 12.7 2.1 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain FANCL_C PF11793.8 CDF32392.1 - 0.22 11.8 3.3 0.58 10.4 3.3 1.8 1 0 0 1 1 1 0 FANCL C-terminal domain DUF2921 PF11145.8 CDF32392.1 - 0.23 9.3 1.2 1.2 6.9 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2921) Prok-RING_4 PF14447.6 CDF32392.1 - 0.42 10.5 7.9 0.87 9.5 7.9 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 CDF32392.1 - 4.6 7.4 9.6 9.1 6.5 9.6 1.5 1 0 0 1 1 1 0 RING-variant domain AICARFT_IMPCHas PF01808.18 CDF32393.1 - 1.5e-113 379.2 1.6 2.2e-113 378.6 1.6 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CDF32393.1 - 1.4e-25 89.3 0.0 3.1e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain PB1 PF00564.24 CDF32394.1 - 6.4e-13 48.4 0.3 2.1e-12 46.8 0.1 2.0 2 0 0 2 2 2 1 PB1 domain ZZ PF00569.17 CDF32394.1 - 7.5e-08 32.1 3.6 1.4e-07 31.2 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type PG_binding_1 PF01471.18 CDF32394.1 - 3e-07 30.5 0.1 6.8e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Paired_CXXCH_1 PF09699.10 CDF32394.1 - 0.91 9.3 3.4 2.3 8.1 3.4 1.7 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) Misat_Tub_SegII PF10644.9 CDF32395.1 - 0.047 14.0 0.0 0.05 13.9 0.0 1.0 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain AMP-binding PF00501.28 CDF32396.1 - 1.5e-75 254.4 1.6 4e-47 160.8 0.1 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CDF32396.1 - 5.4e-17 62.6 2.2 1.9e-16 60.8 0.1 2.7 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 CDF32396.1 - 0.00072 18.5 0.0 0.019 13.9 0.0 2.1 2 0 0 2 2 2 2 GH3 auxin-responsive promoter Piezo_RRas_bdg PF12166.8 CDF32397.1 - 6.7e-53 180.5 0.7 3.5e-52 178.1 0.0 2.6 3 0 0 3 3 3 1 Piezo non-specific cation channel, R-Ras-binding domain Ribosomal_L24e PF01246.20 CDF32398.1 - 1.8e-26 92.1 0.7 5.4e-26 90.6 0.7 1.8 1 0 0 1 1 1 1 Ribosomal protein L24e Exostosin PF03016.15 CDF32398.1 - 0.011 15.0 0.1 0.012 14.8 0.1 1.1 1 0 0 1 1 1 0 Exostosin family FYRC PF05965.14 CDF32398.1 - 0.12 12.6 0.2 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 F/Y rich C-terminus Herpes_UL79 PF03049.14 CDF32398.1 - 0.12 12.0 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 UL79 family TBP PF00352.21 CDF32399.1 - 5.5e-48 160.9 0.2 1e-31 108.7 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CDF32399.1 - 1.8e-06 28.0 0.0 0.018 15.1 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) CNDH2_C PF16858.5 CDF32400.1 - 1.3e-30 107.3 0.1 1.3e-30 107.3 0.1 2.0 2 1 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.11 CDF32400.1 - 3.6e-18 65.8 0.0 8.2e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DREPP PF05558.12 CDF32400.1 - 0.09 12.7 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Ribosomal_S7 PF00177.21 CDF32401.1 - 2.9e-37 127.6 1.3 4.3e-37 127.0 0.7 1.5 2 0 0 2 2 2 1 Ribosomal protein S7p/S5e PPR_2 PF13041.6 CDF32402.1 - 3.8e-51 171.1 3.4 6.5e-16 58.3 0.1 7.9 3 2 5 8 8 8 7 PPR repeat family PPR PF01535.20 CDF32402.1 - 1.8e-48 159.4 0.5 2.9e-07 30.3 0.0 7.9 8 0 0 8 8 8 7 PPR repeat PPR_1 PF12854.7 CDF32402.1 - 2.3e-44 148.8 2.0 1.1e-07 31.4 0.0 7.7 8 0 0 8 8 8 7 PPR repeat PPR_3 PF13812.6 CDF32402.1 - 4.2e-40 135.6 0.0 2.5e-10 40.3 0.0 6.6 3 2 5 8 8 8 6 Pentatricopeptide repeat domain PPR_long PF17177.4 CDF32402.1 - 2.6e-26 92.3 0.0 2.3e-13 50.0 0.0 3.0 1 1 2 3 3 3 2 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 CDF32402.1 - 6.6e-05 21.9 0.0 0.097 11.5 0.0 2.5 2 1 0 2 2 2 2 Mitochondrial 28S ribosomal protein S27 Rgp1 PF08737.10 CDF32403.1 - 1.6e-28 100.0 0.0 3.1e-26 92.5 0.0 2.2 1 1 0 1 1 1 1 Rgp1 Arrestin_C PF02752.22 CDF32403.1 - 0.051 14.0 0.2 7.6 7.0 0.0 3.2 3 1 0 3 3 3 0 Arrestin (or S-antigen), C-terminal domain Rsa3 PF14615.6 CDF32403.1 - 0.17 11.5 0.1 0.3 10.7 0.1 1.4 1 0 0 1 1 1 0 Ribosome-assembly protein 3 EAR PF07897.11 CDF32403.1 - 0.6 9.8 2.6 0.75 9.5 0.2 2.6 2 1 0 2 2 2 0 Ethylene-responsive binding factor-associated repression zf-C2H2 PF00096.26 CDF32404.1 - 1.5e-17 63.0 25.9 1.3e-05 25.4 2.1 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF32404.1 - 2.2e-13 50.0 22.2 0.00066 20.0 0.3 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF32404.1 - 6.4e-13 48.3 24.7 0.00077 20.1 1.6 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CDF32404.1 - 2.3e-07 30.4 20.9 0.00039 20.1 4.4 4.4 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 CDF32404.1 - 1.8e-06 28.0 12.4 0.41 11.0 0.1 4.4 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding DUF1644 PF07800.12 CDF32404.1 - 0.00014 21.9 11.1 0.0044 17.1 3.5 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1644) zf-C2H2_3rep PF18868.1 CDF32404.1 - 0.00044 20.9 8.2 1.5 9.5 8.2 3.6 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 CDF32404.1 - 0.0014 18.9 14.4 0.19 12.2 0.1 4.2 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-BED PF02892.15 CDF32404.1 - 0.007 16.4 1.8 0.007 16.4 1.8 4.6 3 1 2 5 5 5 1 BED zinc finger zf-AN1 PF01428.16 CDF32404.1 - 0.011 15.8 6.3 24 5.2 0.1 4.4 4 0 0 4 4 4 0 AN1-like Zinc finger DUF4442 PF14539.6 CDF32404.1 - 0.064 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) zf-C2H2_8 PF15909.5 CDF32404.1 - 0.12 12.7 15.0 2 8.7 7.4 2.5 1 1 1 2 2 2 0 C2H2-type zinc ribbon FdhD-NarQ PF02634.15 CDF32404.1 - 0.2 11.3 2.8 0.37 10.4 1.3 1.9 1 1 1 2 2 2 0 FdhD/NarQ family HypA PF01155.19 CDF32404.1 - 0.36 10.9 7.0 3.6 7.6 0.6 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 CDF32404.1 - 0.39 11.5 8.3 3.8 8.3 1.8 3.2 2 1 1 3 3 3 0 zinc-ribbon family PyrI_C PF02748.15 CDF32404.1 - 0.4 10.6 3.6 21 5.1 1.0 3.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn-ribbon_8 PF09723.10 CDF32404.1 - 0.41 10.8 12.9 4.5 7.5 3.4 4.4 3 1 2 5 5 4 0 Zinc ribbon domain zf_UBZ PF18439.1 CDF32404.1 - 0.9 9.2 9.3 12 5.6 0.1 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger C1_2 PF03107.16 CDF32404.1 - 1 9.7 14.3 2.3 8.6 0.2 3.9 2 1 1 3 3 3 0 C1 domain zf-C2H2_3 PF13878.6 CDF32404.1 - 1.6 8.6 6.6 1.9 8.4 0.3 3.3 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO zf-H2C2_5 PF13909.6 CDF32404.1 - 1.8 8.4 22.0 0.85 9.4 0.4 4.6 4 0 0 4 4 4 0 C2H2-type zinc-finger domain DUF2197 PF09963.9 CDF32404.1 - 2.2 8.6 6.0 4.1 7.7 1.7 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-C2H2_2 PF12756.7 CDF32404.1 - 6 7.3 15.6 14 6.1 2.8 3.6 1 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Ribosomal_L37ae PF01780.19 CDF32404.1 - 7.5 6.7 7.0 17 5.6 0.1 3.2 1 1 2 3 3 3 0 Ribosomal L37ae protein family rve PF00665.26 CDF32406.1 - 2.1e-17 63.4 0.1 2.9e-17 62.9 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF32406.1 - 4.1e-08 33.2 0.8 1.1e-07 31.9 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDF32406.1 - 0.0025 18.0 0.6 0.0043 17.2 0.6 1.4 1 0 0 1 1 1 1 H2C2 zinc finger AOX PF01786.17 CDF32408.1 - 2.3e-24 86.2 0.3 3.3e-24 85.7 0.3 1.2 1 0 0 1 1 1 1 Alternative oxidase AOX PF01786.17 CDF32410.1 - 1e-22 80.8 0.1 1.5e-22 80.3 0.1 1.2 1 0 0 1 1 1 1 Alternative oxidase zf-C2H2_4 PF13894.6 CDF32411.1 - 2.8e-12 46.3 18.3 0.0025 18.5 1.1 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 CDF32411.1 - 3.7e-10 39.7 19.4 0.026 15.0 1.4 5.1 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF32411.1 - 1.8e-09 37.6 21.9 0.00037 20.8 0.3 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-Di19 PF05605.12 CDF32411.1 - 6e-06 26.5 7.4 2.2e-05 24.7 0.8 2.9 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_SprT PF17283.2 CDF32411.1 - 0.0085 16.0 12.2 0.15 12.0 1.2 2.5 2 0 0 2 2 2 2 SprT-like zinc ribbon domain zf-C2H2_11 PF16622.5 CDF32411.1 - 0.034 13.9 8.5 0.4 10.5 1.3 3.3 2 1 1 3 3 3 0 zinc-finger C2H2-type LIM PF00412.22 CDF32411.1 - 0.072 13.3 7.2 0.095 12.9 1.5 2.5 2 0 0 2 2 2 0 LIM domain zf-C2HE PF16278.5 CDF32411.1 - 0.2 12.1 6.6 1.6 9.3 0.5 3.1 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 CDF32411.1 - 0.25 12.0 21.8 0.14 12.8 3.6 5.5 3 2 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 CDF32411.1 - 0.57 10.4 11.1 0.43 10.8 1.8 3.3 2 1 1 3 3 3 0 Zinc ribbon domain C1_4 PF07975.12 CDF32411.1 - 0.88 9.8 9.4 0.3 11.4 1.6 2.8 1 1 2 3 3 3 0 TFIIH C1-like domain DZR PF12773.7 CDF32411.1 - 1.4 9.1 9.1 8.6 6.5 9.1 2.3 1 1 0 1 1 1 0 Double zinc ribbon Zn-C2H2_12 PF18112.1 CDF32411.1 - 3.2 8.3 6.9 7.7 7.1 0.3 3.4 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain DUF2197 PF09963.9 CDF32411.1 - 4 7.8 10.5 7.4 6.9 0.0 3.5 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2197) zinc_ribbon_5 PF13719.6 CDF32411.1 - 7.3 6.4 9.4 9.9 6.0 0.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 CDF32411.1 - 7.4 6.6 8.5 5.4e+02 0.7 0.1 3.0 1 1 1 2 2 2 0 zinc-ribbons zinc_ribbon_10 PF10058.9 CDF32411.1 - 8.9 6.1 6.0 64 3.4 0.0 3.7 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein DnaJ PF00226.31 CDF32412.1 - 1.8e-20 72.8 0.0 4.7e-20 71.5 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain p450 PF00067.22 CDF32414.1 - 1e-66 225.6 0.0 1.2e-66 225.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SRP19 PF01922.17 CDF32415.1 - 8.1e-26 90.8 0.0 1.1e-25 90.3 0.0 1.2 1 0 0 1 1 1 1 SRP19 protein Peptidase_M50 PF02163.22 CDF32416.1 - 1.6e-07 30.9 4.1 0.00019 20.8 0.2 2.6 1 1 1 2 2 2 2 Peptidase family M50 Nucleotid_trans PF03407.16 CDF32417.1 - 7.4e-39 133.9 0.0 9e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase CSS-motif PF12792.7 CDF32417.1 - 0.045 13.2 0.1 0.16 11.4 0.0 1.9 3 0 0 3 3 3 0 CSS motif domain associated with EAL Epimerase PF01370.21 CDF32418.1 - 8.4e-14 51.6 0.0 5.4e-13 49.0 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CDF32418.1 - 1.8e-13 50.6 0.0 2.5e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 CDF32418.1 - 6.5e-12 45.0 0.0 8.7e-07 28.2 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CDF32418.1 - 9.5e-12 45.2 0.0 1.5e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CDF32418.1 - 4.3e-08 32.6 0.0 2.9e-05 23.3 0.0 2.3 2 1 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDF32418.1 - 0.0035 16.5 0.1 3.2 6.9 0.0 2.5 2 1 0 2 2 2 2 Male sterility protein Lyase_1 PF00206.20 CDF32419.1 - 7.2e-25 88.0 0.0 1.2e-24 87.3 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 CDF32419.1 - 3e-14 53.3 0.1 6.7e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Myb_DNA-binding PF00249.31 CDF32420.1 - 1.3e-13 50.9 0.1 2.7e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF32420.1 - 0.0037 17.1 0.0 0.0094 15.8 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 CDF32420.1 - 0.0054 17.0 0.1 0.012 15.8 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain EccE PF11203.8 CDF32420.1 - 0.17 12.2 3.1 0.8 10.1 0.5 2.5 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE GET2 PF08690.10 CDF32420.1 - 7.4 6.1 6.7 13 5.3 6.7 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 EutK_C PF16365.5 CDF32422.1 - 0.029 14.4 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilization protein EutK C-terminus zf-C2H2 PF00096.26 CDF32423.1 - 1.8e-12 47.0 30.5 0.0023 18.3 1.2 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF32423.1 - 1.7e-11 43.9 28.6 0.0062 17.3 0.9 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF32423.1 - 3.9e-11 42.8 30.3 7e-05 23.1 2.5 4.8 5 0 0 5 5 4 4 Zinc-finger double domain zf-C2H2_8 PF15909.5 CDF32423.1 - 9.7e-05 22.6 15.0 0.025 14.9 4.6 2.2 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 CDF32423.1 - 0.0011 19.7 13.3 0.054 14.2 5.1 3.2 1 1 2 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 CDF32423.1 - 0.0023 17.5 10.8 0.23 11.1 0.2 4.3 4 0 0 4 4 4 1 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 CDF32423.1 - 0.0046 16.7 0.5 0.0046 16.7 0.5 4.5 4 1 0 4 4 4 1 zinc-finger C2H2-type zf-met PF12874.7 CDF32423.1 - 0.025 14.9 18.7 3.1 8.3 0.4 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CDF32423.1 - 0.053 13.5 1.3 0.053 13.5 1.3 4.8 4 2 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CDF32423.1 - 0.056 13.2 0.5 0.056 13.2 0.5 5.5 5 0 0 5 5 5 0 C2H2-type zinc-finger domain PHD PF00628.29 CDF32423.1 - 0.059 13.3 11.6 8.9 6.3 4.4 3.8 3 1 0 3 3 3 0 PHD-finger zinc-ribbons_6 PF07191.12 CDF32423.1 - 0.098 12.6 16.8 7.5 6.6 0.6 3.9 1 1 0 2 2 2 0 zinc-ribbons zf-AN1 PF01428.16 CDF32423.1 - 0.38 11.0 14.6 11 6.3 0.3 4.3 4 0 0 4 4 4 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 CDF32423.1 - 0.62 10.2 17.4 1.9 8.7 5.0 3.4 2 1 1 3 3 3 0 Zinc ribbon domain C1_4 PF07975.12 CDF32423.1 - 1 9.6 17.2 6.3 7.1 0.5 3.4 1 1 3 4 4 4 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 CDF32423.1 - 1.3 9.4 21.8 3.5 8.0 0.7 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Lar_restr_allev PF14354.6 CDF32423.1 - 2.3 8.7 7.9 19 5.7 4.0 3.0 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-MYST PF17772.1 CDF32423.1 - 3 7.5 12.9 0.45 10.1 0.3 3.3 2 1 1 3 3 3 0 MYST family zinc finger domain DUF3795 PF12675.7 CDF32423.1 - 5.4 7.5 13.6 0.82 10.1 7.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3795) zf-C2H2_7 PF15269.6 CDF32423.1 - 5.7 7.1 12.0 0.29 11.3 1.3 3.0 1 1 2 3 3 3 0 Zinc-finger Sirohm_synth_M PF14824.6 CDF32424.1 - 0.095 12.2 0.4 0.24 10.9 0.4 1.7 1 0 0 1 1 1 0 Sirohaem biosynthesis protein central Macoilin PF09726.9 CDF32424.1 - 1.7 7.1 6.5 2 6.9 6.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF4316 PF14195.6 CDF32425.1 - 0.44 10.4 2.0 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4316) Acyltransferase PF01553.21 CDF32427.1 - 1.8e-26 92.4 0.1 2.3e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 Acyltransferase DUF374 PF04028.13 CDF32427.1 - 0.0018 17.8 0.1 0.0032 17.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF374) UEV PF05743.13 CDF32427.1 - 0.19 11.6 0.5 0.92 9.4 0.0 2.1 2 1 0 2 2 2 0 UEV domain P2 PF07194.11 CDF32428.1 - 0.097 12.7 0.1 0.16 12.1 0.1 1.4 1 1 0 1 1 1 0 P2 response regulator binding domain S1 PF00575.23 CDF32429.1 - 1.3e-29 102.3 9.8 2.5e-15 56.5 0.8 3.0 2 1 0 2 2 2 2 S1 RNA binding domain NOC3p PF07540.11 CDF32430.1 - 2.6e-26 91.9 1.1 5.9e-26 90.8 0.4 2.1 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 CDF32430.1 - 3e-11 43.6 0.1 1.1e-10 41.8 0.0 2.0 2 0 0 2 2 2 1 CBF/Mak21 family HEAT_2 PF13646.6 CDF32430.1 - 0.074 13.5 0.3 0.38 11.2 0.4 2.1 2 0 0 2 2 2 0 HEAT repeats HEAT PF02985.22 CDF32430.1 - 0.18 12.1 5.4 3.5 8.1 0.7 3.4 3 0 0 3 3 3 0 HEAT repeat TPR_2 PF07719.17 CDF32431.1 - 8.4e-44 144.2 21.7 0.0043 17.1 0.0 17.5 18 0 0 18 18 18 11 Tetratricopeptide repeat TPR_14 PF13428.6 CDF32431.1 - 4.8e-42 139.0 49.2 2e-05 25.0 1.2 16.9 6 3 11 17 17 17 13 Tetratricopeptide repeat TPR_17 PF13431.6 CDF32431.1 - 1.4e-34 116.0 0.0 0.003 17.8 0.0 14.6 16 0 0 16 16 14 5 Tetratricopeptide repeat TPR_19 PF14559.6 CDF32431.1 - 2.8e-32 111.0 8.8 0.021 15.3 0.0 10.8 9 2 3 12 12 12 9 Tetratricopeptide repeat TPR_12 PF13424.6 CDF32431.1 - 1.1e-26 92.9 26.6 0.00051 20.3 0.9 12.7 8 4 2 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 CDF32431.1 - 4.8e-23 81.5 55.0 6.4e-06 26.7 0.3 11.5 8 2 5 13 13 12 9 Tetratricopeptide repeat TPR_8 PF13181.6 CDF32431.1 - 1.9e-17 61.9 0.4 0.86 10.0 0.0 13.3 15 0 0 15 15 15 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDF32431.1 - 6.4e-16 57.4 3.4 0.081 12.8 0.0 12.2 14 0 0 14 14 14 1 Tetratricopeptide repeat Suf PF05843.14 CDF32431.1 - 3e-12 47.1 2.5 0.13 12.3 0.0 7.7 4 2 2 6 6 6 2 Suppressor of forked protein (Suf) TPR_15 PF13429.6 CDF32431.1 - 6.3e-11 42.0 12.1 0.073 12.3 0.1 6.8 2 1 3 7 7 7 4 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF32431.1 - 1.5e-09 37.9 2.7 3.2 7.8 0.0 9.5 11 1 0 12 12 12 2 Mad3/BUB1 homology region 1 TPR_7 PF13176.6 CDF32431.1 - 3.8e-08 32.8 10.5 0.56 10.4 0.0 9.5 12 1 1 13 13 8 1 Tetratricopeptide repeat MIT PF04212.18 CDF32431.1 - 1.9e-07 31.0 0.0 0.3 11.2 0.0 7.4 9 0 0 9 9 7 1 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 CDF32431.1 - 9.9e-07 29.0 31.3 8.1 7.3 0.1 13.1 16 0 0 16 16 14 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDF32431.1 - 1.6e-05 24.5 0.1 1.1 9.0 0.0 7.0 8 1 1 9 9 8 1 TPR repeat Fis1_TPR_C PF14853.6 CDF32431.1 - 0.00041 20.4 2.8 5.2 7.2 0.0 5.3 6 0 0 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 CDF32431.1 - 0.0015 18.6 36.1 3.3 7.9 0.1 9.7 6 2 2 9 9 9 2 Tetratricopeptide repeat TAtT PF16811.5 CDF32431.1 - 0.0021 17.4 7.7 1.4 8.2 0.1 6.0 3 3 3 6 6 6 1 TRAP transporter T-component NARP1 PF12569.8 CDF32431.1 - 0.0021 17.0 0.0 9.7 5.0 0.0 4.3 5 0 0 5 5 5 0 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 CDF32431.1 - 0.0044 16.8 28.8 9.8 6.2 0.1 11.2 12 0 0 12 12 11 0 Tetratricopeptide repeat HemY_N PF07219.13 CDF32431.1 - 0.0062 16.7 15.5 3.8 7.7 0.1 7.8 4 2 5 9 9 8 1 HemY protein N-terminus TPR_4 PF07721.14 CDF32431.1 - 0.067 13.9 40.7 4.9 8.1 1.8 12.2 12 1 0 12 12 12 0 Tetratricopeptide repeat PPR PF01535.20 CDF32431.1 - 0.08 13.2 22.0 39 4.8 0.0 10.2 13 0 0 13 13 11 0 PPR repeat Wzy_C_2 PF11846.8 CDF32431.1 - 0.25 11.3 2.6 1.5 8.7 0.1 3.4 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal HAGH_C PF16123.5 CDF32432.1 - 4.1e-26 91.3 0.0 7.6e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CDF32432.1 - 3e-08 33.9 0.8 4.2e-07 30.2 0.8 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF32432.1 - 0.04 13.4 0.2 0.14 11.7 0.2 1.9 1 1 1 2 2 2 0 Beta-lactamase superfamily domain Ribosomal_L35Ae PF01247.18 CDF32434.1 - 3e-37 126.7 0.7 3.4e-37 126.5 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CDF32434.1 - 0.00027 21.1 0.0 0.3 11.3 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Ribosomal_S11 PF00411.19 CDF32435.1 - 4.7e-46 155.7 0.5 5.7e-46 155.4 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Pilus_CpaD PF09476.10 CDF32435.1 - 0.02 14.6 0.1 0.025 14.3 0.1 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) CBM_25 PF03423.13 CDF32435.1 - 0.05 13.9 0.0 0.091 13.0 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) Ribosomal_S17 PF00366.20 CDF32436.1 - 4.8e-27 93.9 1.3 6.3e-27 93.5 1.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.5 CDF32436.1 - 1.8e-25 89.1 0.0 4.1e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal PCB_OB PF17092.5 CDF32436.1 - 0.04 14.7 0.0 0.067 14.0 0.0 1.3 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain Rho_RNA_bind PF07497.12 CDF32436.1 - 0.064 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Rho termination factor, RNA-binding domain OmdA PF13376.6 CDF32436.1 - 0.57 10.2 2.3 0.4 10.7 0.6 1.6 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated GTP_EFTU PF00009.27 CDF32437.1 - 1.2e-46 158.7 0.2 1.8e-46 158.1 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDF32437.1 - 2e-17 63.5 0.1 5.8e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDF32437.1 - 3.9e-13 49.6 0.5 2.2e-12 47.2 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF32437.1 - 0.00014 21.9 0.1 0.0033 17.5 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CDF32437.1 - 0.0067 16.3 0.8 0.057 13.3 0.1 2.8 2 0 0 2 2 2 1 Elongation factor Tu domain 4 KTI12 PF08433.10 CDF32437.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF2917 PF11142.8 CDF32441.1 - 0.16 11.4 0.0 0.35 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2917) Corona_NS3b PF03053.14 CDF32442.1 - 0.056 13.2 0.1 0.086 12.6 0.1 1.3 1 1 0 1 1 1 0 ORF3b coronavirus protein Lactamase_B_2 PF12706.7 CDF32444.1 - 1.2e-09 37.9 0.1 0.003 17.1 0.0 3.2 2 2 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF32444.1 - 0.00012 22.1 0.0 0.00041 20.4 0.0 1.9 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily ClpS PF02617.17 CDF32445.1 - 1.3e-06 28.1 0.0 2.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS YjeF_N PF03853.15 CDF32447.1 - 8.3e-25 87.6 0.0 1.4e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus Proteasome PF00227.26 CDF32448.1 - 3e-47 160.6 0.4 3.4e-47 160.4 0.4 1.0 1 0 0 1 1 1 1 Proteasome subunit MTHFR PF02219.17 CDF32449.1 - 2.7e-115 384.6 0.0 4.6e-115 383.9 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1801 PF08818.11 CDF32449.1 - 0.087 13.3 0.0 0.3 11.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DU1801) DNA_pol_E_B PF04042.16 CDF32451.1 - 2.6e-31 108.6 0.0 3.8e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CDF32451.1 - 1.9e-26 92.7 0.0 2.8e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Ribosomal_L3 PF00297.22 CDF32454.1 - 1.4e-21 76.9 8.0 4.3e-20 72.0 3.1 2.5 1 1 2 3 3 3 2 Ribosomal protein L3 PRA-CH PF01502.18 CDF32455.1 - 2.8e-31 107.2 0.0 4.7e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase Adaptin_N PF01602.20 CDF32456.1 - 3.6e-88 296.4 1.2 3.1e-81 273.5 0.5 2.4 3 0 0 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 CDF32456.1 - 8.1e-13 48.7 2.5 1.1e-08 35.2 0.0 3.6 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 CDF32456.1 - 0.0011 19.1 0.2 0.25 11.6 0.0 3.2 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 CDF32456.1 - 0.041 14.1 0.4 49 4.6 0.0 4.4 3 0 0 3 3 3 0 HEAT repeat FANCI_S2 PF14676.6 CDF32456.1 - 0.054 13.8 0.4 46 4.3 0.0 3.6 1 1 1 3 3 3 0 FANCI solenoid 2 LURAP PF14854.6 CDF32456.1 - 0.1 12.5 0.4 0.27 11.2 0.4 1.6 1 0 0 1 1 1 0 Leucine rich adaptor protein AP3D1 PF06375.11 CDF32456.1 - 7.5 6.8 22.2 99 3.1 22.2 2.7 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 ThiF PF00899.21 CDF32457.1 - 2.9e-63 213.5 0.0 4.1e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 CDF32457.1 - 3.5e-16 59.1 0.0 5.5e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 E2 binding domain DUF3649 PF12365.8 CDF32459.1 - 0.0038 16.9 0.0 0.01 15.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3649) DUF295 PF03478.18 CDF32461.1 - 0.06 12.9 1.1 0.33 10.6 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF295) DUF4153 PF13687.6 CDF32461.1 - 0.089 12.4 5.4 0.15 11.7 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4153) Pkinase PF00069.25 CDF32465.1 - 4.3e-54 183.7 0.0 5.6e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32465.1 - 3.7e-38 131.3 0.0 4.6e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF32465.1 - 1.3e-06 28.5 0.3 0.00037 20.5 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 CDF32465.1 - 0.0016 17.8 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF32465.1 - 0.0035 16.2 0.0 0.009 14.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase ABC1 PF03109.16 CDF32465.1 - 0.007 16.5 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 ABC1 family Kinase-like PF14531.6 CDF32465.1 - 0.036 13.4 0.0 0.15 11.3 0.0 2.0 2 1 0 2 2 2 0 Kinase-like Phe_ZIP PF08916.11 CDF32465.1 - 0.1 13.3 0.5 28 5.5 0.0 3.5 2 1 1 3 3 3 0 Phenylalanine zipper TRCF PF03461.15 CDF32465.1 - 0.12 12.8 0.2 0.94 9.9 0.0 2.2 2 0 0 2 2 2 0 TRCF domain FliP PF00813.20 CDF32466.1 - 0.026 14.4 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 FliP family LRR_8 PF13855.6 CDF32466.1 - 0.78 9.5 8.0 1.4 8.8 0.2 4.2 3 2 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.7 CDF32466.1 - 0.89 10.1 10.2 18 5.9 0.2 4.9 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) GTP_EFTU PF00009.27 CDF32467.1 - 1.1e-49 168.7 0.1 1.4e-49 168.3 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDF32467.1 - 0.0009 19.6 2.6 0.004 17.5 2.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF32467.1 - 0.0012 18.9 0.0 0.0023 18.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF32467.1 - 0.0045 16.9 0.0 0.055 13.4 0.0 2.1 1 1 1 2 2 2 1 RsgA GTPase cobW PF02492.19 CDF32467.1 - 0.011 15.4 0.0 0.39 10.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Polyoma_lg_T_C PF06431.11 CDF32467.1 - 0.062 12.2 0.0 0.095 11.6 0.0 1.2 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus RT_RNaseH PF17917.1 CDF32470.1 - 6e-22 77.9 0.1 6.1e-20 71.5 0.0 3.0 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF32470.1 - 6.1e-21 74.8 0.0 1.4e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF32470.1 - 6e-14 51.9 0.1 1.1e-13 51.1 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 CDF32470.1 - 9.8e-13 48.0 0.1 8.6e-08 32.1 0.0 2.9 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF32470.1 - 0.0005 19.6 1.0 0.4 10.2 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF32470.1 - 0.00063 19.5 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDF32470.1 - 0.0015 18.7 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger zf-H2C2_2 PF13465.6 CDF32471.1 - 6.3e-20 70.6 35.5 2.4e-05 24.5 2.1 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 CDF32471.1 - 1.9e-17 62.6 33.3 1.4e-05 25.3 1.7 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF32471.1 - 3.1e-17 61.8 29.1 0.0026 18.4 1.4 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDF32471.1 - 2.2e-05 24.6 25.4 0.18 12.1 0.8 6.2 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 CDF32471.1 - 0.00018 22.2 12.0 0.18 12.5 0.2 4.2 2 1 1 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 CDF32471.1 - 0.00054 20.4 20.7 2.6 8.6 1.7 5.1 1 1 3 4 4 4 3 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 CDF32471.1 - 0.00086 19.0 3.8 0.039 13.7 1.4 6.1 6 0 0 6 6 6 3 C2H2-type zinc-finger domain zf-met PF12874.7 CDF32471.1 - 0.0058 17.0 26.6 0.84 10.1 0.8 6.0 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-AN1 PF01428.16 CDF32471.1 - 0.01 16.0 14.0 16 5.8 0.1 5.3 5 0 0 5 5 5 0 AN1-like Zinc finger zf-C2H2_11 PF16622.5 CDF32471.1 - 0.023 14.4 23.8 0.025 14.3 0.1 4.9 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 CDF32471.1 - 0.26 11.3 33.1 1.5 8.9 1.3 5.7 5 1 0 5 5 5 0 C2H2-type zinc finger zf-BED PF02892.15 CDF32471.1 - 0.93 9.6 23.7 0.26 11.3 1.2 3.9 2 1 2 4 4 4 0 BED zinc finger zf-MYST PF17772.1 CDF32471.1 - 0.94 9.1 5.8 7.4 6.3 0.3 3.4 2 1 1 3 3 3 0 MYST family zinc finger domain LIM PF00412.22 CDF32471.1 - 1.5 9.1 15.0 9.4 6.6 5.7 3.6 1 1 3 4 4 4 0 LIM domain BIR PF00653.21 CDF32471.1 - 1.8 9.3 13.3 0.2 12.3 0.5 3.4 3 0 0 3 3 3 0 Inhibitor of Apoptosis domain zinc_ribbon_9 PF14369.6 CDF32471.1 - 2.3 8.5 10.5 13 6.2 0.1 4.2 4 0 0 4 4 4 0 zinc-ribbon Zn-ribbon_8 PF09723.10 CDF32471.1 - 2.7 8.2 15.2 7.5 6.8 1.4 3.9 2 2 2 4 4 4 0 Zinc ribbon domain zf-C2H2_8 PF15909.5 CDF32471.1 - 3.2 8.1 19.7 1.2 9.5 1.7 3.2 2 1 1 3 3 3 0 C2H2-type zinc ribbon TFIIA PF03153.13 CDF32471.1 - 4.9 7.0 8.8 5.5 6.9 8.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_transf_7C PF02709.14 CDF32472.1 - 7.5e-08 31.9 0.0 1.7e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glycos_transf_2 PF00535.26 CDF32472.1 - 1.3e-07 31.6 0.3 2.7e-07 30.6 0.3 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 NodZ PF05830.11 CDF32472.1 - 0.0001 21.3 0.1 0.0032 16.4 0.0 2.5 2 0 0 2 2 2 1 Nodulation protein Z (NodZ) Glyco_tranf_2_2 PF10111.9 CDF32472.1 - 0.00012 21.6 0.2 0.0023 17.5 0.1 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 XG_FTase PF03254.13 CDF32472.1 - 0.0014 17.4 0.0 0.24 10.0 0.0 2.2 2 0 0 2 2 2 2 Xyloglucan fucosyltransferase AhpC-TSA PF00578.21 CDF32473.1 - 3.8e-32 110.8 0.0 5.1e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF32473.1 - 3.7e-14 52.7 0.0 4.9e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDF32473.1 - 3.7e-11 42.7 0.3 1.1e-10 41.1 0.1 2.0 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin Thioredoxin_8 PF13905.6 CDF32473.1 - 0.00058 20.1 0.0 0.0011 19.2 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA_2 PF13911.6 CDF32473.1 - 0.063 13.4 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme ANAPC4_WD40 PF12894.7 CDF32475.1 - 3.8e-16 59.2 15.4 0.91 9.9 0.1 11.2 10 3 2 12 12 12 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF32475.1 - 9.5e-08 32.6 25.4 0.23 12.4 0.0 10.4 10 1 0 10 10 10 3 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF32475.1 - 2.4e-07 30.6 21.7 8.8e-06 25.5 2.8 4.6 4 1 1 5 5 5 3 PQQ-like domain PQQ PF01011.21 CDF32475.1 - 6.5e-05 22.7 11.3 0.34 10.9 0.1 6.6 7 0 0 7 7 7 2 PQQ enzyme repeat PD40 PF07676.12 CDF32475.1 - 0.0063 16.4 8.5 47 4.1 0.0 7.7 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat APAF1_C PF17908.1 CDF32475.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain eIF2A PF08662.11 CDF32475.1 - 0.035 14.0 0.8 0.52 10.2 0.0 3.2 4 0 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A NB-ARC PF00931.22 CDF32475.1 - 0.087 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DPPIV_N PF00930.21 CDF32475.1 - 0.22 10.2 2.1 2.1 7.0 0.1 2.9 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region HA PF03457.14 CDF32476.1 - 3.3e-05 24.1 0.0 0.0014 18.9 0.0 3.2 2 0 0 2 2 2 1 Helicase associated domain R2K_3 PF14243.6 CDF32477.1 - 0.089 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Glyco_hydro_31 PF01055.26 CDF32480.1 - 4.9e-47 161.1 0.0 7e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF3138 PF11336.8 CDF32480.1 - 0.12 11.0 0.0 0.28 9.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) TLD PF07534.16 CDF32481.1 - 3e-36 124.7 0.0 3.8e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 TLD RNA_pol_Rpb4 PF03874.16 CDF32482.1 - 2.3e-14 53.8 1.7 4.3e-14 52.9 1.7 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb4 adh_short PF00106.25 CDF32484.1 - 5.8e-46 156.4 0.0 7.7e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF32484.1 - 1.2e-26 93.7 0.0 1.9e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF32484.1 - 1.6e-15 57.5 0.0 2.1e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CDF32484.1 - 0.0032 16.8 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 CDF32484.1 - 0.0064 16.4 0.1 0.014 15.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CDF32484.1 - 0.022 14.2 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pyr_redox PF00070.27 CDF32484.1 - 0.033 14.7 0.3 0.073 13.6 0.3 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDF32484.1 - 0.087 12.0 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.21 CDF32484.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 CDF32484.1 - 0.12 12.8 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 CDF32484.1 - 0.15 11.9 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 CDF32484.1 - 0.29 10.9 1.9 1.2 8.9 1.9 1.9 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Hep_59 PF07052.11 CDF32485.1 - 2.8e-13 50.5 0.0 2.8e-13 50.5 0.0 2.5 2 1 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 NUDIX_5 PF16705.5 CDF32485.1 - 0.064 13.0 0.8 3.6 7.3 0.5 2.2 2 0 0 2 2 2 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT DUF3117 PF11314.8 CDF32486.1 - 0.13 12.1 0.1 0.31 10.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3117) TRAPP PF04051.16 CDF32487.1 - 1.6e-35 121.9 0.0 2e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PK PF00224.21 CDF32491.1 - 9.8e-108 360.1 0.2 1.6e-107 359.4 0.2 1.3 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDF32491.1 - 3.7e-25 88.4 0.0 7.2e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain IMPDH PF00478.25 CDF32491.1 - 0.0087 15.1 0.1 0.031 13.3 0.0 1.8 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain HpcH_HpaI PF03328.14 CDF32491.1 - 0.052 12.7 0.2 0.44 9.7 0.0 2.3 2 1 0 3 3 3 0 HpcH/HpaI aldolase/citrate lyase family TPR_9 PF13371.6 CDF32493.1 - 2.2e-13 50.1 11.6 0.00029 20.9 0.1 5.6 3 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDF32493.1 - 7.2e-13 47.6 18.0 0.18 12.0 0.0 10.0 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDF32493.1 - 2.2e-10 40.9 19.9 0.0061 17.1 0.2 6.9 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF32493.1 - 2.7e-06 27.6 22.9 0.013 15.8 0.4 7.0 7 2 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF32493.1 - 4.4e-06 27.2 17.2 0.0041 17.7 0.2 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat NARP1 PF12569.8 CDF32493.1 - 0.00012 21.2 0.7 0.00065 18.7 0.2 2.2 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_8 PF13181.6 CDF32493.1 - 0.00014 21.8 9.7 14 6.2 0.1 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF32493.1 - 0.0009 19.0 23.4 5.4 7.0 0.1 8.9 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_3 PF07720.12 CDF32493.1 - 0.0012 18.8 0.4 1.6 8.8 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF32493.1 - 0.0029 17.9 13.5 1.5 9.3 0.1 6.9 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDF32493.1 - 0.0098 15.3 6.7 2.4 7.5 4.3 3.6 2 1 1 3 3 3 2 MalT-like TPR region ANAPC3 PF12895.7 CDF32493.1 - 0.017 15.3 2.8 9.6 6.5 0.0 5.5 6 2 0 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDF32493.1 - 0.023 14.7 13.2 4 7.7 0.0 7.6 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF32493.1 - 0.039 14.8 31.3 0.72 10.8 0.3 9.1 9 3 3 12 12 7 0 Tetratricopeptide repeat MIT PF04212.18 CDF32493.1 - 0.1 12.7 2.3 8.3 6.6 0.2 4.1 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Coatomer_E PF04733.14 CDF32493.1 - 0.14 11.5 0.1 11 5.3 0.1 3.0 3 1 0 3 3 3 0 Coatomer epsilon subunit TPR_11 PF13414.6 CDF32493.1 - 1.3 8.8 6.6 36 4.1 0.0 5.1 6 1 0 6 6 6 0 TPR repeat TPR_6 PF13174.6 CDF32493.1 - 3.2 8.6 21.7 60 4.6 0.1 9.2 10 0 0 10 10 10 0 Tetratricopeptide repeat PGA2 PF07543.12 CDF32494.1 - 0.012 15.5 1.1 0.018 15.0 1.1 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 DEAD PF00270.29 CDF32495.1 - 1.2e-20 74.0 0.0 2e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF32495.1 - 7.1e-13 48.9 0.0 2e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CDF32495.1 - 2.3e-10 41.0 11.2 2.5e-10 40.9 4.6 2.6 2 0 0 2 2 2 1 RecQ zinc-binding AAA_22 PF13401.6 CDF32495.1 - 0.015 15.6 0.0 0.17 12.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain YL1 PF05764.13 CDF32495.1 - 6.3 6.8 11.1 0.37 10.9 5.7 1.6 2 0 0 2 2 2 0 YL1 nuclear protein His_Phos_1 PF00300.22 CDF32497.1 - 2.6e-16 59.9 0.0 5e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF1746 PF08508.10 CDF32499.1 - 2.1e-07 31.2 2.8 3.1e-07 30.7 2.8 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Helicase_C PF00271.31 CDF32501.1 - 1.1e-15 57.9 0.0 2.1e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain NDK PF00334.19 CDF32502.1 - 3.6e-27 95.0 0.0 4.6e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.19 CDF32503.1 - 0.00022 21.2 0.1 0.00027 21.0 0.1 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase zf-HIT PF04438.16 CDF32504.1 - 1.4e-05 24.9 9.1 2.4e-05 24.1 9.1 1.4 1 0 0 1 1 1 1 HIT zinc finger CDP-OH_P_transf PF01066.21 CDF32505.1 - 1.9e-13 51.0 1.7 2.3e-13 50.7 0.5 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Asparaginase_2 PF01112.18 CDF32506.1 - 1.4e-60 204.9 9.6 1.8e-60 204.6 9.6 1.0 1 0 0 1 1 1 1 Asparaginase HRI1 PF16815.5 CDF32508.1 - 0.028 14.1 0.2 0.035 13.8 0.2 1.4 1 0 0 1 1 1 0 Protein HRI1 PsaD PF02531.16 CDF32508.1 - 0.031 13.8 0.0 0.061 12.8 0.0 1.5 2 0 0 2 2 2 0 PsaD DNA_photolyase PF00875.18 CDF32509.1 - 2.1e-22 79.9 1.3 4.7e-22 78.7 1.3 1.5 1 0 0 1 1 1 1 DNA photolyase FAT PF02259.23 CDF32511.1 - 1.1e-37 130.1 4.4 1.1e-37 130.1 4.4 2.6 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CDF32511.1 - 5.7e-12 46.0 0.0 1.4e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CDF32511.1 - 1.6e-05 24.6 0.1 1.6e-05 24.6 0.1 2.8 3 0 0 3 3 3 1 FATC domain DUF1539 PF07560.11 CDF32511.1 - 0.15 12.1 0.2 2.2 8.4 0.0 3.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) zf-H3C2 PF16721.5 CDF32512.1 - 0.0055 17.0 0.3 0.011 16.0 0.3 1.6 1 1 0 1 1 1 1 Zinc-finger like, probable DNA-binding Integrase_H2C2 PF17921.1 CDF32512.1 - 0.017 15.2 1.6 0.072 13.2 1.6 2.0 1 1 0 1 1 1 0 Integrase zinc binding domain Holin_SPP1 PF04688.13 CDF32512.1 - 0.08 13.1 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 SPP1 phage holin zf-C2H2 PF00096.26 CDF32513.1 - 1.3e-18 66.3 28.2 0.00098 19.5 0.1 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF32513.1 - 1.1e-14 53.8 28.8 0.0011 19.6 0.2 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF32513.1 - 1.6e-10 40.9 29.9 0.00019 21.7 0.2 5.8 6 0 0 6 6 5 4 Zinc-finger double domain zf-C2H2_11 PF16622.5 CDF32513.1 - 2.6e-05 23.9 20.6 0.017 14.9 0.8 4.8 5 0 0 5 5 4 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 CDF32513.1 - 0.00024 21.2 12.2 0.037 14.2 0.3 3.7 2 2 1 3 3 3 3 Zinc ribbon domain zf_UBZ PF18439.1 CDF32513.1 - 0.00076 19.0 12.8 1.3 8.7 0.2 5.1 5 0 0 5 5 5 2 Ubiquitin-Binding Zinc Finger zf-H2C2_5 PF13909.6 CDF32513.1 - 0.00099 18.8 1.1 0.087 12.6 0.2 5.9 6 0 0 6 6 5 3 C2H2-type zinc-finger domain zf-met PF12874.7 CDF32513.1 - 0.0045 17.3 8.2 4.6 7.8 0.7 4.3 4 0 0 4 4 4 1 Zinc-finger of C2H2 type CpXC PF14353.6 CDF32513.1 - 0.011 15.8 12.2 6.5 6.8 0.1 4.7 1 1 4 5 5 5 0 CpXC protein zf-C2H2_3rep PF18868.1 CDF32513.1 - 0.015 16.0 18.9 8.1 7.1 8.2 4.8 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats Rpr2 PF04032.16 CDF32513.1 - 0.017 15.4 10.6 0.54 10.6 0.7 3.7 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zinc_ribbon_4 PF13717.6 CDF32513.1 - 0.022 14.7 15.2 0.83 9.6 0.8 5.2 4 1 0 4 4 4 0 zinc-ribbon domain DUF1677 PF07911.13 CDF32513.1 - 0.062 13.7 1.3 1 9.8 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1677) GAGA PF09237.11 CDF32513.1 - 0.11 12.4 4.8 4 7.3 0.3 2.8 2 0 0 2 2 2 0 GAGA factor OrfB_Zn_ribbon PF07282.11 CDF32513.1 - 0.16 11.9 18.1 6.8 6.7 2.9 5.1 2 1 2 5 5 5 0 Putative transposase DNA-binding domain ADK_lid PF05191.14 CDF32513.1 - 0.19 11.7 6.5 5.3 7.1 0.2 4.1 3 1 1 4 4 4 0 Adenylate kinase, active site lid zf-UDP PF14569.6 CDF32513.1 - 0.2 11.8 6.0 3.8 7.7 6.0 2.5 1 1 0 1 1 1 0 Zinc-binding RING-finger zinc_ribbon_10 PF10058.9 CDF32513.1 - 0.21 11.4 9.5 1.3 8.8 1.1 3.3 3 1 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein HypA PF01155.19 CDF32513.1 - 0.37 10.8 11.3 13 5.8 4.4 3.3 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 CDF32513.1 - 0.45 10.3 22.6 0.93 9.3 1.4 5.1 5 0 0 5 5 5 0 Rubredoxin metal binding domain CxC5 PF18718.1 CDF32513.1 - 0.49 10.5 0.1 0.49 10.5 0.1 3.3 2 1 0 4 4 3 0 CxC5 like cysteine cluster associated with KDZ transposases zf-C2H2_9 PF16293.5 CDF32513.1 - 0.63 9.9 3.1 2.1 8.2 0.2 3.0 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-MYND PF01753.18 CDF32513.1 - 0.69 10.1 10.1 9.9 6.3 0.7 3.6 3 1 0 3 3 3 0 MYND finger zf-C2H2_jaz PF12171.8 CDF32513.1 - 0.79 10.1 9.5 4 7.8 1.4 4.0 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-FPG_IleRS PF06827.14 CDF32513.1 - 0.91 9.4 17.8 2.1 8.3 0.2 5.1 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS Actin_micro PF17003.5 CDF32513.1 - 1 8.5 13.6 3.4 6.7 0.4 3.6 1 1 1 2 2 2 0 Putative actin-like family zf-AN1 PF01428.16 CDF32513.1 - 2.2 8.5 17.4 8.1 6.7 0.1 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger zf-C2H2_8 PF15909.5 CDF32513.1 - 2.3 8.6 15.7 5.5 7.4 0.5 3.4 2 1 2 4 4 3 0 C2H2-type zinc ribbon PhnA_Zn_Ribbon PF08274.12 CDF32513.1 - 2.4 8.2 7.9 2.1 8.3 0.2 3.3 3 0 0 3 3 3 0 PhnA Zinc-Ribbon FYVE_2 PF02318.16 CDF32513.1 - 2.5 8.3 7.8 0.85 9.8 2.9 2.1 1 1 1 2 2 2 0 FYVE-type zinc finger zf-C2H2_2 PF12756.7 CDF32513.1 - 3 8.3 14.9 11 6.5 1.7 3.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF4379 PF14311.6 CDF32513.1 - 3.2 8.2 11.2 2.3 8.7 0.3 3.2 2 1 1 3 3 3 0 Probable Zinc-ribbon domain Terminase_GpA PF05876.12 CDF32513.1 - 3.4 6.1 10.7 1.1 7.7 2.3 2.1 1 1 1 2 2 2 0 Phage terminase large subunit (GpA) zf-BED PF02892.15 CDF32513.1 - 3.8 7.6 18.4 7.7 6.6 0.7 4.8 4 1 1 5 5 5 0 BED zinc finger zf-Sec23_Sec24 PF04810.15 CDF32513.1 - 4 7.6 14.1 1.9 8.6 0.2 4.4 4 1 0 4 4 4 0 Sec23/Sec24 zinc finger zf-piccolo PF05715.13 CDF32513.1 - 5.3 7.3 12.0 45 4.3 9.3 3.2 1 1 1 2 2 2 0 Piccolo Zn-finger zf-C2H2_7 PF15269.6 CDF32513.1 - 7.1 6.8 9.2 8.8 6.5 0.1 3.5 3 1 1 4 4 3 0 Zinc-finger DUF2757 PF10955.8 CDF32513.1 - 8.2 6.8 10.8 0.67 10.3 0.2 3.8 4 1 1 5 5 5 0 Protein of unknown function (DUF2757) GFA PF04828.14 CDF32513.1 - 9.8 6.6 12.7 28 5.1 0.5 4.2 1 1 4 5 5 5 0 Glutathione-dependent formaldehyde-activating enzyme DNA_pol_A_exo1 PF01612.20 CDF32514.1 - 3.1e-38 131.2 0.0 4.7e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 CDF32514.1 - 4.4e-05 24.1 0.0 0.00062 20.4 0.0 2.6 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 CDF32514.1 - 0.00024 21.0 0.0 0.0007 19.5 0.0 1.9 1 0 0 1 1 1 1 HRDC domain hNIFK_binding PF12196.8 CDF32514.1 - 9.1 5.9 7.0 2.4 7.7 0.1 2.9 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK Ribonuc_red_sm PF00268.21 CDF32515.1 - 2.4e-108 361.8 0.0 2.8e-108 361.6 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF1350 PF07082.11 CDF32516.1 - 1.7e-41 142.1 0.0 4.8e-40 137.4 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1350) Sybindin PF04099.12 CDF32517.1 - 7.2e-32 110.3 0.1 8.2e-32 110.1 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CDF32517.1 - 0.0087 16.2 0.1 0.0093 16.1 0.1 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Keratin_2_head PF16208.5 CDF32518.1 - 0.053 13.7 1.1 0.086 13.0 1.1 1.2 1 0 0 1 1 1 0 Keratin type II head Lipase_GDSL_2 PF13472.6 CDF32519.1 - 1.2e-26 94.2 0.0 1.6e-26 93.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDF32519.1 - 6e-14 52.5 0.0 1.3e-13 51.4 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Diphthamide_syn PF01866.17 CDF32520.1 - 4.7e-103 344.8 0.0 5.5e-103 344.6 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein GTP_EFTU PF00009.27 CDF32521.1 - 9.7e-39 132.9 0.0 1.4e-38 132.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDF32521.1 - 4.1e-31 107.6 0.1 1.3e-30 105.9 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDF32521.1 - 6.8e-09 36.0 0.3 1.8e-08 34.7 0.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF32521.1 - 0.0022 18.1 0.1 0.0069 16.4 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase PAM2 PF07145.15 CDF32521.1 - 0.0048 16.5 0.1 0.062 13.0 0.1 2.4 2 0 0 2 2 2 1 Ataxin-2 C-terminal region RNase_II_C_S1 PF18614.1 CDF32521.1 - 0.12 12.4 0.3 0.26 11.3 0.3 1.6 1 0 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain G-alpha PF00503.20 CDF32521.1 - 0.21 10.7 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit DIE2_ALG10 PF04922.12 CDF32524.1 - 4.1e-80 270.0 0.1 5.1e-40 138.0 0.0 2.0 1 1 1 2 2 2 2 DIE2/ALG10 family MRP_L53 PF10780.9 CDF32525.1 - 5.8e-08 32.8 0.0 1.5e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 DUF4129 PF13559.6 CDF32525.1 - 1.7 9.0 9.1 5.8 7.3 6.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4129) DUF773 PF05600.12 CDF32527.1 - 1.7e-25 89.8 0.0 2e-25 89.5 0.0 1.0 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 HetR_C PF18460.1 CDF32527.1 - 0.044 13.7 2.4 0.089 12.7 1.5 1.9 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain APG6_N PF17675.1 CDF32527.1 - 0.35 11.4 2.2 0.67 10.5 2.2 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF563 PF04577.14 CDF32529.1 - 3e-21 76.5 0.1 1.7e-20 74.0 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF563) Creatinase_N_2 PF16189.5 CDF32531.1 - 8.7e-48 162.5 0.0 1.5e-47 161.7 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CDF32531.1 - 2e-41 142.0 0.0 3e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 CDF32531.1 - 1.3e-23 82.9 0.3 2.7e-23 81.8 0.3 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CDF32531.1 - 9.1e-07 29.6 0.0 0.0004 21.0 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain 5_nucleotid_C PF02872.18 CDF32532.1 - 4.2e-36 124.5 0.0 7.4e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CDF32532.1 - 7.4e-10 39.7 0.1 1e-09 39.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF32532.1 - 0.018 15.2 0.1 0.33 11.1 0.1 2.3 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Thioredoxin_10 PF17991.1 CDF32532.1 - 0.11 13.0 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin like C-terminal domain SAP PF02037.27 CDF32533.1 - 4.9e-10 38.9 0.1 5.7e-07 29.2 0.0 3.3 2 1 1 3 3 3 2 SAP domain HeH PF12949.7 CDF32533.1 - 6e-05 22.7 0.2 0.00047 19.8 0.1 2.4 2 0 0 2 2 2 1 HeH/LEM domain FHA PF00498.26 CDF32533.1 - 0.0063 16.8 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain ANAPC4_WD40 PF12894.7 CDF32534.1 - 0.021 15.1 0.0 0.057 13.7 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF32534.1 - 0.062 14.2 0.2 1.6 9.7 0.0 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat RPN7 PF10602.9 CDF32535.1 - 1.3e-34 119.5 0.3 1.3e-34 119.5 0.3 1.6 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 CDF32535.1 - 4.4e-11 43.2 0.0 1.2e-10 41.9 0.0 1.8 1 0 0 1 1 1 1 PCI domain NDUF_B7 PF05676.13 CDF32535.1 - 0.036 13.8 0.1 0.098 12.4 0.1 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF1664 PF07889.12 CDF32536.1 - 2e-12 47.2 1.4 4.8e-12 46.0 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Prot_ATP_OB_N PF17758.1 CDF32536.1 - 0.044 13.4 0.1 7.7 6.2 0.0 2.4 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain Neuromodulin PF06614.11 CDF32536.1 - 0.1 12.8 0.2 0.1 12.8 0.2 2.0 2 0 0 2 2 2 0 Neuromodulin TTKRSYEDQ PF10212.9 CDF32536.1 - 0.12 11.3 0.0 0.3 10.0 0.0 1.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF3490 PF11995.8 CDF32536.1 - 0.33 10.8 1.0 6.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3490) Consortin_C PF15281.6 CDF32536.1 - 3.8 7.5 5.5 2.5 8.1 0.1 3.1 4 0 0 4 4 4 0 Consortin C-terminus XG_FTase PF03254.13 CDF32537.1 - 0.00079 18.2 0.1 0.49 9.0 0.0 3.0 3 0 0 3 3 3 2 Xyloglucan fucosyltransferase NodZ PF05830.11 CDF32537.1 - 0.017 13.9 0.5 0.36 9.6 0.0 2.5 3 0 0 3 3 3 0 Nodulation protein Z (NodZ) A_deaminase PF00962.22 CDF32538.1 - 9.3e-35 120.5 0.0 1.2e-34 120.2 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase P53_C PF11619.8 CDF32538.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain Rep_fac-A_C PF08646.10 CDF32539.1 - 1e-31 109.6 0.0 1.2e-28 99.7 0.0 2.9 3 0 0 3 3 3 2 Replication factor-A C terminal domain Rep-A_N PF04057.12 CDF32539.1 - 1.3e-28 99.0 0.5 4e-28 97.4 0.1 2.0 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain REPA_OB_2 PF16900.5 CDF32539.1 - 3.8e-23 81.3 0.1 3.5e-21 75.0 0.0 2.8 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 CDF32539.1 - 2.2e-08 34.0 0.1 2.2e-05 24.4 0.0 2.9 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain DUF5521 PF17659.1 CDF32539.1 - 0.09 10.6 0.1 1.8 6.3 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5521) UTP15_C PF09384.10 CDF32540.1 - 4.5e-32 110.8 0.2 6.3e-32 110.3 0.2 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 CDF32540.1 - 4.8e-14 52.5 9.4 2.2e-05 25.1 0.0 7.3 6 1 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32540.1 - 5.2e-05 23.5 0.0 2.3 8.6 0.0 4.6 2 2 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF32540.1 - 0.0099 14.9 0.9 2.4 7.0 0.0 3.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CDF32540.1 - 0.027 13.0 0.4 2 6.8 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF5122 PF17164.4 CDF32540.1 - 0.044 14.1 0.2 0.12 12.6 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5122) beta-propeller PQQ_3 PF13570.6 CDF32540.1 - 0.26 11.8 1.1 56 4.4 0.0 3.3 3 0 0 3 3 3 0 PQQ-like domain Gln-synt_C PF00120.24 CDF32542.1 - 2.8e-16 59.5 0.0 1e-12 47.7 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CDF32542.1 - 9.8e-10 38.0 0.0 2.2e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Alpha-amylase PF00128.24 CDF32543.1 - 5e-15 55.9 0.1 0.00018 21.2 0.1 4.1 3 1 0 3 3 3 3 Alpha amylase, catalytic domain CBM_48 PF02922.18 CDF32543.1 - 0.00011 22.4 0.0 0.00026 21.3 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) hDGE_amylase PF14701.6 CDF32543.1 - 0.16 11.1 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DHR10 PF18595.1 CDF32544.1 - 0.017 15.2 1.7 0.055 13.5 1.7 2.0 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain TFIIA PF03153.13 CDF32545.1 - 0.0011 19.1 13.6 0.0022 18.0 1.1 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit MIP PF00230.20 CDF32548.1 - 2.7e-24 86.1 15.7 3.4e-24 85.8 15.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein IlvB_leader PF08049.11 CDF32548.1 - 0.36 10.8 3.6 18 5.4 0.2 2.9 2 0 0 2 2 2 0 IlvB leader peptide SSF PF00474.17 CDF32549.1 - 9.5e-17 60.9 32.8 9.5e-17 60.9 32.8 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family SOP4 PF17081.5 CDF32549.1 - 0.46 10.0 1.5 5 6.6 0.2 2.6 3 0 0 3 3 3 0 Suppressor of PMA 1-7 protein Proteasome PF00227.26 CDF32550.1 - 1.5e-46 158.3 0.2 2e-46 157.9 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit COG4 PF08318.12 CDF32551.1 - 3e-37 128.5 1.2 2.6e-25 89.2 0.5 2.2 1 1 1 2 2 2 2 COG4 transport protein Ribonuclease_3 PF00636.26 CDF32551.1 - 0.045 14.4 0.1 0.15 12.7 0.1 1.8 1 0 0 1 1 1 0 Ribonuclease III domain Herpes_UL92 PF03048.14 CDF32551.1 - 0.063 13.1 0.1 0.44 10.3 0.1 2.2 2 0 0 2 2 2 0 UL92 family Gluconate_2-dh3 PF13618.6 CDF32551.1 - 0.078 13.2 0.9 0.36 11.1 0.1 2.4 3 0 0 3 3 3 0 Gluconate 2-dehydrogenase subunit 3 Erf4 PF10256.9 CDF32551.1 - 0.18 11.9 0.0 0.87 9.7 0.0 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family CHAD PF05235.14 CDF32551.1 - 0.23 11.4 5.3 2.7 7.9 2.6 2.4 2 1 0 2 2 2 0 CHAD domain Flavin_Reduct PF01613.18 CDF32556.1 - 2.7e-09 37.3 3.8 8.7e-09 35.6 1.7 2.6 2 1 0 2 2 2 1 Flavin reductase like domain WD40 PF00400.32 CDF32559.1 - 0.00018 22.2 1.2 0.45 11.5 0.0 4.3 4 1 0 4 4 4 1 WD domain, G-beta repeat PD40 PF07676.12 CDF32559.1 - 0.014 15.3 5.0 5.8 7.0 0.1 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat I-set PF07679.16 CDF32559.1 - 0.11 12.6 0.5 24 5.1 0.3 2.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain PQQ PF01011.21 CDF32559.1 - 0.26 11.3 2.3 26 5.0 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat WD40 PF00400.32 CDF32560.1 - 0.013 16.4 0.3 0.35 11.8 0.1 3.3 3 0 0 3 3 3 0 WD domain, G-beta repeat PD40 PF07676.12 CDF32560.1 - 0.28 11.2 2.1 13 5.9 0.1 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat RTP1_C1 PF10363.9 CDF32562.1 - 0.019 15.1 0.0 0.04 14.1 0.0 1.6 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 DDE_3 PF13358.6 CDF32563.1 - 1.4e-12 47.5 0.0 1.9e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 CDF32564.1 - 1.5e-07 31.9 5.9 2.9e-06 27.8 1.7 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_38 PF13936.6 CDF32564.1 - 6.7e-07 29.0 4.4 7.5e-07 28.8 0.3 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_1 PF11427.8 CDF32564.1 - 8.5e-06 25.5 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_23 PF13384.6 CDF32564.1 - 0.0047 16.7 3.3 0.41 10.5 0.0 2.6 2 1 0 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF32564.1 - 0.0048 17.1 1.8 0.0073 16.5 0.6 1.8 1 1 1 2 2 2 1 Transposase TrmB PF01978.19 CDF32564.1 - 0.032 14.1 0.4 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB LacI PF00356.21 CDF32564.1 - 0.032 14.0 1.9 7.5 6.4 0.3 2.8 1 1 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_29 PF13551.6 CDF32564.1 - 0.035 14.1 0.3 0.22 11.6 0.1 2.2 1 1 1 2 2 2 0 Winged helix-turn helix DUF977 PF06163.11 CDF32564.1 - 0.078 12.9 0.2 0.18 11.7 0.2 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF977) MarR_2 PF12802.7 CDF32564.1 - 0.098 12.6 2.7 2.2 8.2 0.1 2.5 1 1 1 2 2 2 0 MarR family HTH_11 PF08279.12 CDF32564.1 - 0.28 11.1 2.4 15 5.6 0.6 2.4 2 0 0 2 2 2 0 HTH domain DDE_3 PF13358.6 CDF32565.1 - 1.8e-13 50.5 0.0 2.8e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.32 CDF32567.1 - 1.3e-43 146.2 35.6 7.6e-08 32.9 0.8 7.2 7 0 0 7 7 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32567.1 - 3.3e-14 53.0 5.7 0.2 12.0 0.1 6.4 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF32567.1 - 1.4e-13 50.6 0.0 2.8e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Me-amine-dh_H PF06433.11 CDF32567.1 - 7.8e-06 25.0 0.3 0.067 12.0 0.0 3.0 1 1 2 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.8 CDF32567.1 - 0.00029 19.6 5.0 4.2 5.9 0.1 4.8 1 1 4 5 5 5 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 CDF32567.1 - 0.0008 19.1 21.0 0.011 15.4 7.8 3.0 1 1 1 2 2 2 2 PQQ-like domain Peptidase_S9_N PF02897.15 CDF32567.1 - 0.0034 16.3 6.0 2.5 6.8 0.1 4.2 1 1 3 4 4 4 2 Prolyl oligopeptidase, N-terminal beta-propeller domain WD40_like PF17005.5 CDF32567.1 - 0.0096 15.3 0.0 30 3.8 0.0 4.7 4 1 2 6 6 6 0 WD40-like domain PQQ_3 PF13570.6 CDF32567.1 - 0.014 15.9 6.4 15 6.3 0.0 5.2 4 1 1 5 5 5 0 PQQ-like domain PQQ PF01011.21 CDF32567.1 - 0.017 15.0 10.9 26 5.0 0.1 5.7 5 1 0 5 5 5 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 CDF32567.1 - 0.045 12.7 0.8 26 3.6 0.0 4.2 1 1 4 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA PF00004.29 CDF32567.1 - 0.13 12.7 0.0 12 6.3 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF32567.1 - 0.13 12.5 0.0 0.41 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain RT_RNaseH PF17917.1 CDF32570.1 - 1.4e-22 79.9 0.0 5.2e-22 78.1 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF32570.1 - 1.7e-19 70.1 0.0 5e-19 68.6 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDF32570.1 - 2.7e-17 62.6 0.1 9.4e-17 60.9 0.1 1.9 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF32570.1 - 1.8e-10 40.8 0.2 9.5e-10 38.4 0.2 2.4 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF32570.1 - 3.6e-05 23.6 0.0 8.4e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF32570.1 - 0.006 16.3 0.0 0.028 14.2 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDF32570.1 - 0.34 11.2 2.2 2.5 8.4 0.0 3.6 4 0 0 4 4 4 0 H2C2 zinc finger TMV_coat PF00721.21 CDF32576.1 - 0.0031 17.4 0.0 0.0041 17.0 0.0 1.1 1 0 0 1 1 1 1 Virus coat protein (TMV like) RT_RNaseH PF17917.1 CDF32578.1 - 1.6e-28 99.1 0.0 1e-27 96.5 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF32578.1 - 2.4e-24 85.3 0.0 8.9e-24 83.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF32578.1 - 1.2e-17 64.2 0.0 2.3e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF32578.1 - 1.6e-11 44.1 2.3 1.6e-11 44.1 2.3 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 CDF32578.1 - 4.7e-05 23.1 0.3 0.0046 16.7 0.0 3.2 3 0 0 3 3 3 1 Integrase core domain WD40 PF00400.32 CDF32580.1 - 3e-41 138.6 28.8 5.9e-11 42.8 0.6 8.7 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32580.1 - 8.3e-29 99.7 9.3 7e-07 29.5 0.0 7.6 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF32580.1 - 1.5e-14 53.8 0.0 2.5e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain eIF2A PF08662.11 CDF32580.1 - 8.7e-09 35.5 0.0 0.0007 19.5 0.0 3.4 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CDF32580.1 - 3.2e-08 33.3 1.9 0.25 11.3 0.0 5.6 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CDF32580.1 - 0.012 14.6 0.0 5.2 5.9 0.0 3.9 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF32580.1 - 0.29 10.4 0.0 52 3.0 0.0 3.7 2 2 2 4 4 4 0 WD40-like domain TFIIIC_delta PF12657.7 CDF32580.1 - 0.73 9.7 5.0 1.6e+02 2.1 0.0 4.5 3 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term SLATT_3 PF18184.1 CDF32581.1 - 0.43 10.7 5.7 4.3 7.5 0.1 2.4 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 Plant_tran PF04827.14 CDF32582.1 - 8.1e-58 195.4 0.0 1.1e-57 194.9 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF32582.1 - 1.3e-09 38.0 0.0 1.9e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease An_peroxidase PF03098.15 CDF32584.1 - 2.1e-109 366.5 0.0 2.4e-109 366.3 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 CDF32585.1 - 6.3e-109 365.0 0.0 7.8e-109 364.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase RSN1_7TM PF02714.15 CDF32586.1 - 4.1e-17 62.4 11.7 5.6e-17 62.0 11.7 1.2 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate DUF3493 PF11998.8 CDF32587.1 - 4.1e-14 52.5 0.1 8.3e-14 51.5 0.1 1.5 1 0 0 1 1 1 1 Low psii accumulation1 / Rep27 RNase_Zc3h12a PF11977.8 CDF32589.1 - 3.7e-12 46.3 0.2 1.1e-11 44.7 0.0 1.9 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain PRORP PF16953.5 CDF32589.1 - 0.00037 20.1 1.0 0.00067 19.2 0.1 1.9 2 0 0 2 2 2 1 Protein-only RNase P RNase_Zc3h12a PF11977.8 CDF32590.1 - 2.1e-12 47.1 0.3 3.9e-12 46.2 0.3 1.5 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Herpes_UL49_2 PF04823.12 CDF32590.1 - 0.052 13.7 0.3 3.1 8.0 0.0 2.9 3 0 0 3 3 3 0 Herpesvirus UL49 tegument protein tRNA_U5-meth_tr PF05958.11 CDF32592.1 - 5.9e-16 58.4 0.0 1.3e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 CDF32592.1 - 1.4e-11 44.4 0.2 2.4e-11 43.6 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF32592.1 - 4.3e-09 36.9 0.0 1.7e-08 35.1 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDF32592.1 - 7.6e-08 32.2 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 CDF32592.1 - 8.7e-08 31.9 0.1 1.5e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 CDF32592.1 - 1e-07 31.6 0.1 1.8e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CDF32592.1 - 9.4e-06 25.2 0.6 1.5e-05 24.6 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CDF32592.1 - 2.9e-05 24.1 0.0 5.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDF32592.1 - 0.00056 19.9 0.2 0.001 19.0 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDF32592.1 - 0.00086 19.1 0.1 0.0013 18.5 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.12 CDF32592.1 - 0.0012 19.4 0.0 0.0045 17.6 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF32592.1 - 0.0017 17.8 0.1 0.0027 17.1 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TPMT PF05724.11 CDF32592.1 - 0.003 17.2 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_4 PF02390.17 CDF32592.1 - 0.0072 15.8 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.18 CDF32592.1 - 0.023 14.4 0.3 0.19 11.4 0.3 2.2 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 CDF32592.1 - 0.024 15.3 0.1 0.053 14.3 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CDF32592.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 CDF32592.1 - 0.028 13.5 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase AviRa PF11599.8 CDF32592.1 - 0.035 13.6 0.0 0.058 12.8 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_23 PF13489.6 CDF32592.1 - 0.037 13.9 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain N6_Mtase PF02384.16 CDF32592.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 N-6 DNA Methylase TehB PF03848.14 CDF32592.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB SLD5_C PF16922.5 CDF32593.1 - 2.2e-17 63.0 0.0 4.5e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus DUF1287 PF06940.11 CDF32593.1 - 0.04 13.6 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) SWC7 PF17330.2 CDF32593.1 - 0.091 12.8 1.2 2.6 8.2 1.2 2.3 1 1 0 1 1 1 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 KIP1 PF07765.12 CDF32593.1 - 0.4 10.8 2.6 0.49 10.5 1.2 1.8 2 0 0 2 2 2 0 KIP1-like protein Sld5 PF05916.11 CDF32593.1 - 0.51 10.8 3.0 0.52 10.8 1.6 1.9 2 1 0 2 2 2 0 GINS complex protein WD40 PF00400.32 CDF32594.1 - 7.4e-11 42.4 5.3 0.00032 21.5 0.1 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32594.1 - 1e-10 41.8 0.4 0.026 14.8 0.0 4.4 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain IL2 PF00715.17 CDF32595.1 - 0.0057 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Interleukin 2 BEX PF04538.12 CDF32595.1 - 0.73 10.5 4.8 0.2 12.3 0.2 2.2 2 0 0 2 2 2 0 Brain expressed X-linked like family DFRP_C PF16543.5 CDF32596.1 - 7e-15 55.3 2.5 7e-15 55.3 2.5 3.1 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 BLOC1S3 PF15753.5 CDF32597.1 - 0.018 15.2 0.4 0.018 15.2 0.4 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 eIF2A PF08662.11 CDF32600.1 - 3.9e-48 163.9 0.0 5.1e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Enkurin PF13864.6 CDF32600.1 - 4.7 7.7 10.8 8.3 6.9 10.8 1.4 1 0 0 1 1 1 0 Calmodulin-binding GTA_holin_3TM PF11351.8 CDF32601.1 - 0.045 14.3 1.2 0.06 13.9 0.5 1.6 1 1 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Vps55 PF04133.14 CDF32601.1 - 0.062 13.3 3.4 0.13 12.2 3.4 1.6 1 1 0 1 1 1 0 Vacuolar protein sorting 55 MSP1a PF11670.8 CDF32601.1 - 0.11 11.8 7.9 0.17 11.2 0.1 2.1 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) DUF4491 PF14898.6 CDF32601.1 - 0.32 11.5 6.3 1.6 9.2 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) RRM_1 PF00076.22 CDF32604.1 - 1.5e-16 60.0 0.0 2.6e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF32604.1 - 0.0034 17.4 0.0 0.0072 16.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif Methyltransf_33 PF10017.9 CDF32605.1 - 1.6e-93 313.3 0.1 1.8e-93 313.1 0.1 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_25 PF13649.6 CDF32605.1 - 0.005 17.5 0.0 0.013 16.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CDF32605.1 - 0.012 15.1 0.1 0.77 9.2 0.0 2.3 2 0 0 2 2 2 0 Putative methyltransferase Peptidase_M1 PF01433.20 CDF32605.1 - 0.025 14.2 0.1 0.044 13.4 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M1 domain Methyltransf_12 PF08242.12 CDF32605.1 - 0.042 14.6 0.0 0.16 12.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Apolipoprotein PF01442.18 CDF32607.1 - 0.0022 17.9 2.5 0.0026 17.7 2.5 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF3347 PF11827.8 CDF32607.1 - 0.042 14.0 0.9 0.049 13.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) GvpL_GvpF PF06386.11 CDF32607.1 - 0.063 13.2 2.2 0.072 13.0 2.2 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Methyltransf_14 PF08484.11 CDF32607.1 - 0.15 11.8 1.2 0.48 10.2 1.4 1.6 1 1 1 2 2 2 0 C-methyltransferase C-terminal domain YtxH PF12732.7 CDF32607.1 - 0.21 12.1 3.7 0.71 10.5 3.7 1.8 1 1 0 1 1 1 0 YtxH-like protein ATP-synt_B PF00430.18 CDF32607.1 - 0.22 11.6 8.8 0.41 10.7 8.8 1.4 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) T3SS_needle_F PF09392.10 CDF32607.1 - 0.58 10.4 4.3 2.4 8.4 0.4 2.1 1 1 1 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Adap_comp_sub PF00928.21 CDF32608.1 - 1.3e-85 286.9 0.0 1.7e-85 286.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDF32608.1 - 4.8e-08 33.1 1.7 8.6e-08 32.2 1.7 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CDF32608.1 - 0.0023 17.4 0.0 0.0051 16.3 0.0 1.6 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain NUFIP1 PF10453.9 CDF32609.1 - 1.9e-09 37.2 0.3 5.7e-09 35.7 0.3 1.8 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) PGA2 PF07543.12 CDF32609.1 - 0.77 9.7 11.6 1.2 9.2 11.6 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 bZIP_1 PF00170.21 CDF32611.1 - 0.6 10.3 4.5 1.1 9.4 4.5 1.3 1 0 0 1 1 1 0 bZIP transcription factor Glyco_trans_2_3 PF13632.6 CDF32612.1 - 2.5e-20 73.2 5.6 6.3e-20 71.9 5.6 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CDF32612.1 - 2.8e-11 43.7 0.0 4.2e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 SCIMP PF15050.6 CDF32612.1 - 0.023 15.2 0.1 0.11 12.9 0.1 2.1 2 0 0 2 2 2 0 SCIMP protein UL41A PF17591.2 CDF32612.1 - 0.083 13.0 0.1 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus UL41A CPBP PF02517.16 CDF32615.1 - 1.6e-14 54.1 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 CPBP intramembrane metalloprotease DUF2953 PF11167.8 CDF32615.1 - 0.15 12.2 0.1 0.32 11.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) DUF5392 PF17370.2 CDF32615.1 - 0.17 12.0 0.0 0.2 11.8 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5392) DUF2781 PF10914.8 CDF32617.1 - 0.048 14.1 0.8 0.048 14.1 0.8 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) SLT PF01464.20 CDF32618.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain Flavodoxin_1 PF00258.25 CDF32621.1 - 2.9e-20 72.9 0.0 3.1e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 CDF32621.1 - 8.2e-06 26.1 0.0 1.1e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_3 PF12641.7 CDF32621.1 - 9.7e-06 25.4 0.0 1.7e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain DUF1989 PF09347.10 CDF32623.1 - 8.5e-57 191.4 0.0 1.1e-56 191.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) AhpC-TSA PF00578.21 CDF32624.1 - 9.4e-29 99.9 0.0 1.3e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF32624.1 - 6.8e-13 48.6 0.0 9.5e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDF32624.1 - 0.00046 20.0 0.4 0.0015 18.4 0.4 1.9 1 1 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 CDF32624.1 - 0.0063 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme rve PF00665.26 CDF32625.1 - 3.8e-16 59.4 0.0 6.2e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF32625.1 - 6.3e-06 25.9 0.0 1.6e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CDF32625.1 - 0.001 19.1 3.9 0.001 19.1 3.9 2.3 2 0 0 2 2 2 1 Zinc knuckle DUF1281_C PF18406.1 CDF32625.1 - 0.0012 18.5 0.2 0.0042 16.8 0.2 1.8 2 0 0 2 2 2 1 Ferredoxin-like domain in Api92-like protein zf-CCHC_5 PF14787.6 CDF32625.1 - 0.24 11.1 4.5 0.76 9.5 4.5 1.9 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Helicase_C PF00271.31 CDF32626.1 - 2.3e-15 56.9 0.0 6.5e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF32626.1 - 2.1e-08 34.1 0.0 6.5e-08 32.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF32626.1 - 0.096 12.7 0.0 0.39 10.7 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Glyco_transf_28 PF03033.20 CDF32627.1 - 1.7e-32 112.3 0.0 3e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 CDF32627.1 - 3.9e-32 111.5 0.2 5.4e-32 111.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_4 PF13579.6 CDF32627.1 - 0.00016 22.1 5.8 0.0012 19.3 0.1 2.9 1 1 2 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CDF32627.1 - 0.00081 19.8 0.2 0.002 18.6 0.2 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 LpxB PF02684.15 CDF32627.1 - 0.0011 17.9 0.0 0.0023 16.9 0.0 1.5 2 0 0 2 2 2 1 Lipid-A-disaccharide synthetase Glyco_transf_4 PF13439.6 CDF32627.1 - 0.0029 17.6 0.0 0.087 12.8 0.0 2.2 1 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_3 PF13528.6 CDF32627.1 - 0.0053 16.0 0.0 0.016 14.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 1 Mur_ligase_M PF08245.12 CDF32628.1 - 5e-18 65.8 0.0 7.2e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDF32628.1 - 7.1e-10 39.0 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain Glycos_transf_4 PF00953.21 CDF32629.1 - 3.3e-28 98.7 7.4 3.3e-28 98.7 7.4 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF2569 PF10754.9 CDF32629.1 - 0.5 10.8 5.0 2.8 8.4 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Syndecan PF01034.20 CDF32629.1 - 2.1 8.3 3.9 1.4 8.9 0.4 2.4 2 0 0 2 2 2 0 Syndecan domain AhpC-TSA PF00578.21 CDF32630.1 - 2e-18 66.5 0.0 4.3e-18 65.4 0.0 1.5 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 CDF32630.1 - 6e-10 39.0 0.0 8.1e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin Adenylsucc_synt PF00709.21 CDF32632.1 - 6e-170 565.7 0.0 6.8e-170 565.5 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DAHP_synth_2 PF01474.16 CDF32633.1 - 4e-186 618.8 0.0 4.6e-186 618.6 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family DotD PF16816.5 CDF32633.1 - 0.11 12.4 0.0 0.47 10.4 0.0 2.0 2 0 0 2 2 2 0 DotD protein Actin PF00022.19 CDF32634.1 - 1.2e-67 228.3 0.0 3.3e-66 223.6 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDF32634.1 - 0.0055 15.6 0.0 0.11 11.2 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Drf_FH1 PF06346.12 CDF32634.1 - 0.06 13.1 10.1 0.021 14.6 7.3 1.6 2 0 0 2 2 2 0 Formin Homology Region 1 RVT_1 PF00078.27 CDF32635.1 - 0.00097 18.7 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AhpC-TSA PF00578.21 CDF32636.1 - 8.8e-28 96.7 0.0 1.1e-27 96.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF32636.1 - 1.1e-10 41.4 0.0 1.4e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDF32636.1 - 1.8e-10 40.4 0.1 3.4e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Sorb PF02208.16 CDF32636.1 - 0.14 12.0 0.0 0.37 10.7 0.0 1.7 1 0 0 1 1 1 0 Sorbin homologous domain Metalloenzyme PF01676.18 CDF32637.1 - 2.2e-37 128.8 0.0 2.2e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CDF32637.1 - 1.4e-30 106.4 0.6 4.5e-30 104.7 0.1 1.8 2 0 0 2 2 2 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 CDF32637.1 - 0.00072 19.2 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PIG-L PF02585.17 CDF32637.1 - 0.081 13.6 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase Acetyltransf_1 PF00583.25 CDF32641.1 - 2.5e-11 43.8 0.0 3.3e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF32641.1 - 8.4e-08 32.2 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF32641.1 - 1.8e-06 28.3 0.0 2.6e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF32641.1 - 0.0043 17.0 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDF32641.1 - 0.016 15.3 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDF32641.1 - 0.048 13.8 0.0 0.065 13.4 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CDF32641.1 - 0.077 12.5 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_CG PF14542.6 CDF32641.1 - 0.16 12.2 0.4 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase HSP70 PF00012.20 CDF32645.1 - 4.1e-260 864.1 10.0 4.7e-260 863.9 10.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDF32645.1 - 4.7e-12 45.4 3.1 4.6e-11 42.1 0.0 2.9 3 0 0 3 3 3 1 MreB/Mbl protein TMEM247 PF15444.6 CDF32645.1 - 0.0043 17.1 2.9 0.0077 16.3 2.1 1.7 2 0 0 2 2 2 1 Transmembrane protein 247 FGGY_C PF02782.16 CDF32645.1 - 0.047 13.4 0.1 0.35 10.6 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain DUF4115 PF13464.6 CDF32645.1 - 0.14 12.3 0.0 0.53 10.5 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) MutS_III PF05192.18 CDF32645.1 - 1.5 9.0 3.7 39 4.4 0.0 2.3 2 0 0 2 2 2 0 MutS domain III GFO_IDH_MocA PF01408.22 CDF32646.1 - 4.3e-26 92.1 0.7 7.8e-26 91.3 0.7 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDF32646.1 - 3.3e-10 40.0 0.0 6.3e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 CDF32646.1 - 0.0014 19.1 0.4 0.0037 17.8 0.4 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.16 CDF32646.1 - 0.014 16.1 0.2 0.029 15.0 0.2 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDF32646.1 - 0.05 13.0 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CDF32646.1 - 0.11 13.0 0.1 0.31 11.5 0.1 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Peripla_BP_1 PF00532.21 CDF32646.1 - 0.19 11.1 1.0 0.43 9.9 0.2 1.8 2 0 0 2 2 2 0 Periplasmic binding proteins and sugar binding domain of LacI family Sacchrp_dh_NADP PF03435.18 CDF32646.1 - 0.33 11.2 5.4 0.2 11.9 1.6 2.4 2 2 1 3 3 3 0 Saccharopine dehydrogenase NADP binding domain FG-GAP_2 PF14312.6 CDF32647.1 - 0.00045 20.4 0.3 0.038 14.3 0.0 2.7 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.6 CDF32647.1 - 0.0066 17.0 0.2 0.054 14.1 0.1 2.4 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDF32647.1 - 0.018 15.2 2.9 4.8 7.4 0.8 2.7 2 0 0 2 2 2 0 FG-GAP repeat Thioredoxin PF00085.20 CDF32649.1 - 6.7e-54 180.2 5.5 1.8e-31 108.2 0.2 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CDF32649.1 - 5.2e-30 104.7 9.8 1.3e-17 64.3 0.1 3.7 3 1 1 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.13 CDF32649.1 - 1.9e-10 40.6 0.3 8.7e-05 22.0 0.1 2.9 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CDF32649.1 - 2.7e-10 40.7 3.6 5.7e-06 26.8 0.3 3.8 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDF32649.1 - 2.1e-09 37.4 1.9 0.00016 21.7 0.0 3.6 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CDF32649.1 - 2e-06 28.1 0.7 0.35 11.2 0.1 4.0 3 1 1 4 4 3 3 Thioredoxin-like Thioredoxin_3 PF13192.6 CDF32649.1 - 3.4e-06 27.0 0.7 0.0017 18.3 0.0 3.1 3 0 0 3 3 3 1 Thioredoxin domain AhpC-TSA PF00578.21 CDF32649.1 - 4.1e-06 26.7 0.3 0.013 15.4 0.1 2.7 2 0 0 2 2 2 2 AhpC/TSA family ERp29_N PF07912.13 CDF32649.1 - 1.6e-05 25.1 0.8 0.001 19.2 0.2 2.7 2 0 0 2 2 2 1 ERp29, N-terminal domain Redoxin PF08534.10 CDF32649.1 - 0.0012 18.5 3.0 0.45 10.2 0.2 3.2 3 1 0 4 4 4 2 Redoxin Glutaredoxin PF00462.24 CDF32649.1 - 0.0037 17.4 0.1 0.98 9.7 0.0 3.0 2 0 0 2 2 2 1 Glutaredoxin DIM1 PF02966.16 CDF32649.1 - 0.0042 16.9 0.4 0.029 14.2 0.1 2.4 3 0 0 3 3 3 1 Mitosis protein DIM1 LepB_N PF18640.1 CDF32649.1 - 0.038 13.6 0.2 0.72 9.4 0.0 2.4 2 0 0 2 2 2 0 LepB N-terminal domain Thioredoxin_9 PF14595.6 CDF32649.1 - 0.045 13.5 0.0 0.68 9.7 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin RRM_1 PF00076.22 CDF32652.1 - 5e-18 64.7 0.0 8.3e-18 64.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 CDF32652.1 - 5.2e-15 55.9 2.9 5.2e-15 55.9 2.9 1.6 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_8 PF11835.8 CDF32652.1 - 0.076 13.2 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 RRM-like domain RRM_7 PF16367.5 CDF32652.1 - 0.12 12.5 0.1 0.37 11.0 0.1 1.8 1 1 0 1 1 1 0 RNA recognition motif Glyco_transf_20 PF00982.21 CDF32653.1 - 1.5e-150 502.0 0.0 1.9e-150 501.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CDF32653.1 - 1.1e-49 168.7 0.0 4.3e-49 166.7 0.0 1.9 1 1 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 CDF32653.1 - 2.5e-06 27.4 0.0 0.051 13.3 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_4 PF12146.8 CDF32654.1 - 1.8e-48 164.9 0.0 3.1e-47 160.8 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF32654.1 - 3.9e-11 43.1 0.1 4.5e-08 33.0 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF32654.1 - 5.6e-11 43.5 1.3 7.4e-11 43.1 1.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 CDF32654.1 - 6.5e-07 29.2 0.1 1.1e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 CDF32654.1 - 0.00013 21.5 0.0 0.17 11.3 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDF32654.1 - 0.00091 18.9 0.0 0.0043 16.7 0.0 1.9 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_5 PF12695.7 CDF32654.1 - 0.0016 18.3 0.0 0.49 10.2 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family Lipase_3 PF01764.25 CDF32654.1 - 0.006 16.5 0.1 0.024 14.5 0.0 1.9 2 1 0 2 2 2 1 Lipase (class 3) FSH1 PF03959.13 CDF32654.1 - 0.019 14.6 0.0 0.041 13.5 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 CDF32654.1 - 0.019 14.7 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 CDF32654.1 - 0.043 13.9 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Esterase_phd PF10503.9 CDF32654.1 - 0.055 13.0 1.0 7.9 5.9 0.1 2.4 3 0 0 3 3 3 0 Esterase PHB depolymerase DLH PF01738.18 CDF32654.1 - 0.16 11.5 0.0 10 5.6 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF3598 PF12204.8 CDF32655.1 - 9.4e-09 35.1 0.0 0.0011 18.6 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3598) GXWXG PF14231.6 CDF32655.1 - 0.064 13.3 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 GXWXG protein Rpp20 PF12328.8 CDF32656.1 - 0.0014 18.6 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P DUF2733 PF10813.8 CDF32656.1 - 0.087 12.6 0.5 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2733) Chisel PF15355.6 CDF32659.1 - 0.14 12.4 0.2 0.14 12.4 0.2 2.1 1 1 0 2 2 2 0 Stretch-responsive small skeletal muscle X protein, Chisel Retinal PF15449.6 CDF32659.1 - 0.39 8.4 17.1 0.48 8.2 17.1 1.0 1 0 0 1 1 1 0 Retinal protein ECH_1 PF00378.20 CDF32664.1 - 1.1e-71 241.1 0.2 1.2e-71 240.9 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDF32664.1 - 5.6e-33 114.8 0.2 4.9e-31 108.5 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 CDF32664.1 - 0.0057 15.7 0.1 0.01 14.9 0.1 1.3 1 0 0 1 1 1 1 Serine dehydrogenase proteinase Peptidase_S49 PF01343.18 CDF32664.1 - 0.015 15.2 0.7 0.54 10.2 0.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 DUF5538 PF17692.1 CDF32664.1 - 0.062 13.4 0.3 0.16 12.0 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5538) NADH_B2 PF14813.6 CDF32665.1 - 0.011 15.5 2.2 0.015 15.1 2.2 1.3 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 CpeT PF06206.11 CDF32666.1 - 2.9e-47 161.0 0.0 3.6e-47 160.7 0.0 1.0 1 0 0 1 1 1 1 CpeT/CpcT family (DUF1001) Myb_DNA-binding PF00249.31 CDF32668.1 - 5.9e-27 93.6 2.1 2.6e-12 46.7 0.2 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF32668.1 - 3.2e-20 72.1 0.0 2.9e-10 40.2 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 CDF32668.1 - 0.0051 16.8 0.0 1.4 8.9 0.0 2.3 1 1 1 2 2 2 2 SLIDE Myb_DNA-bind_7 PF15963.5 CDF32668.1 - 0.0091 15.9 0.2 0.016 15.1 0.2 1.4 1 0 0 1 1 1 1 Myb DNA-binding like Rap1_C PF11626.8 CDF32668.1 - 0.033 14.3 1.0 6.3 7.0 0.0 2.3 1 1 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain R3H PF01424.22 CDF32676.1 - 0.003 17.5 0.1 0.0054 16.7 0.1 1.4 1 0 0 1 1 1 1 R3H domain Trypsin_2 PF13365.6 CDF32677.1 - 3.5e-32 112.4 0.3 7.9e-32 111.2 0.3 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDF32677.1 - 1.4e-13 51.2 0.0 2.9e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 CDF32677.1 - 1.5e-11 44.5 0.2 3.5e-11 43.3 0.2 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDF32677.1 - 0.0078 16.0 1.0 1.3 8.9 0.1 2.6 2 0 0 2 2 2 2 PDZ domain GRASP55_65 PF04495.14 CDF32677.1 - 0.01 16.1 0.0 0.03 14.6 0.0 1.7 1 1 0 1 1 1 0 GRASP55/65 PDZ-like domain Peptidase_S29 PF02907.15 CDF32677.1 - 0.012 15.4 0.1 0.028 14.1 0.1 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Peptidase_S32 PF05579.13 CDF32677.1 - 0.039 13.2 0.5 7.8 5.6 0.0 2.3 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 PDZ PF00595.24 CDF32677.1 - 0.039 14.3 2.2 1.7 9.0 2.2 2.6 1 1 0 1 1 1 0 PDZ domain Peptidase_S46 PF10459.9 CDF32677.1 - 0.094 11.3 0.3 0.17 10.5 0.3 1.3 1 0 0 1 1 1 0 Peptidase S46 Bax1-I PF01027.20 CDF32684.1 - 1.6e-22 80.4 32.0 2e-22 80.0 32.0 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF3021 PF11457.8 CDF32684.1 - 0.22 11.9 29.7 0.063 13.6 19.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) Pkinase PF00069.25 CDF32686.1 - 8.1e-58 195.9 0.0 1.1e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32686.1 - 1.1e-27 97.0 0.0 1.5e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF32686.1 - 0.00037 20.5 0.0 0.00081 19.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF32686.1 - 0.00056 19.3 0.0 0.0016 17.8 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDF32686.1 - 0.018 13.9 0.0 0.033 13.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Helicase_C PF00271.31 CDF32687.1 - 9e-21 74.3 0.0 4.1e-16 59.3 0.0 3.4 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 CDF32687.1 - 1.5e-14 54.1 0.0 5.6e-14 52.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF32687.1 - 3.2e-06 27.2 0.0 5.9e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 CDF32687.1 - 4.4e-06 27.3 1.3 1.1e-05 26.1 1.3 1.7 1 0 0 1 1 1 1 RecQ zinc-binding SNF2_N PF00176.23 CDF32687.1 - 0.059 12.1 0.0 0.11 11.2 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain Med22 PF06179.12 CDF32688.1 - 0.19 12.0 0.8 0.7 10.1 0.3 2.1 2 0 0 2 2 2 0 Surfeit locus protein 5 subunit 22 of Mediator complex SMC_N PF02463.19 CDF32689.1 - 5.9e-19 68.4 0.0 6.9e-18 64.9 0.0 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDF32689.1 - 1.2e-15 58.6 6.3 1.2e-15 58.6 6.3 4.2 2 2 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CDF32689.1 - 1.1e-07 32.0 0.1 0.017 15.0 0.0 3.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDF32689.1 - 8.7e-07 29.0 13.1 1.8e-05 24.7 0.4 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDF32689.1 - 5.3e-05 22.9 0.0 0.0001 21.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CDF32689.1 - 0.067 13.7 0.0 0.067 13.7 0.0 4.1 3 2 1 4 4 4 0 ABC transporter HlyD_2 PF12700.7 CDF32689.1 - 1.7 7.3 10.2 6.5 5.4 10.2 1.9 1 0 0 1 1 1 0 HlyD family secretion protein DUF3138 PF11336.8 CDF32689.1 - 4 5.9 5.3 1.5 7.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Pkinase PF00069.25 CDF32691.1 - 3.4e-69 233.1 0.0 3.9e-69 233.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32691.1 - 3.9e-39 134.5 0.0 4.7e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF32691.1 - 2.2e-05 23.9 0.0 0.00021 20.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 CDF32691.1 - 0.064 12.3 0.0 0.13 11.3 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 ATP_transf PF09830.9 CDF32691.1 - 0.093 12.9 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 ATP adenylyltransferase FTA2 PF13095.6 CDF32691.1 - 0.11 12.1 0.0 3.2 7.3 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 IL6Ra-bind PF09240.10 CDF32693.1 - 0.054 13.9 0.5 0.27 11.7 0.5 2.2 1 1 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding DUF5313 PF17240.2 CDF32694.1 - 0.056 13.9 0.3 0.12 12.8 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5313) Pkinase PF00069.25 CDF32695.1 - 7.9e-47 159.8 0.0 1e-46 159.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32695.1 - 1.9e-28 99.5 0.0 2.4e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF32695.1 - 1.1e-05 24.9 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF32695.1 - 0.005 16.8 2.0 0.013 15.5 0.0 2.5 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF32695.1 - 0.05 12.4 0.0 0.076 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CDF32695.1 - 0.076 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF4974 PF16344.5 CDF32695.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4974) FTA2 PF13095.6 CDF32695.1 - 0.19 11.3 0.0 6.8 6.2 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HU-CCDC81_euk_1 PF14908.6 CDF32699.1 - 0.011 15.8 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 Lip_A_acyltrans PF03279.13 CDF32699.1 - 0.15 11.2 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase GATA PF00320.27 CDF32702.1 - 7.1e-06 25.5 1.8 1.6e-05 24.4 1.8 1.6 1 0 0 1 1 1 1 GATA zinc finger LSM PF01423.22 CDF32707.1 - 0.0065 16.1 0.1 0.0084 15.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain His_biosynth PF00977.21 CDF32708.1 - 1.5e-28 99.8 0.0 1.9e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein SQS_PSY PF00494.19 CDF32709.1 - 9.8e-41 140.0 0.0 1.4e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase TIP49 PF06068.13 CDF32713.1 - 1.4e-93 314.0 5.9 2.2e-49 168.6 3.0 2.0 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 CDF32713.1 - 6.3e-09 35.9 0.3 4.4e-08 33.1 0.2 2.5 3 0 0 3 3 3 1 TIP49 AAA-lid domain DnaB_C PF03796.15 CDF32713.1 - 2e-05 24.1 0.6 4.2e-05 23.0 0.6 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA PF00004.29 CDF32713.1 - 0.0035 17.8 0.4 0.017 15.6 0.2 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDF32713.1 - 0.004 17.1 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 CDF32713.1 - 0.019 14.5 0.2 0.077 12.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CDF32713.1 - 0.087 12.2 0.9 0.26 10.6 0.2 2.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDF32713.1 - 0.13 12.2 0.1 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Proton_antipo_M PF00361.20 CDF32714.1 - 4.9e-70 236.0 24.4 1.5e-64 218.0 17.3 2.5 1 1 1 2 2 2 2 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 CDF32714.1 - 2.6e-23 81.9 1.9 1.3e-22 79.6 1.9 2.4 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Mito_carr PF00153.27 CDF32715.1 - 2.1e-42 143.0 4.7 1.2e-18 66.8 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PAF PF15715.5 CDF32721.1 - 1.6 9.3 4.5 2.3 8.8 4.5 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Transketolase_C PF02780.20 CDF32723.1 - 5.1e-27 94.2 0.0 7.4e-27 93.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain WD40 PF00400.32 CDF32724.1 - 2.1e-14 53.7 6.5 1.2e-06 29.1 0.5 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32724.1 - 0.00062 20.0 0.3 1.2 9.4 0.0 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF32724.1 - 0.0027 16.4 0.1 0.58 8.7 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CDF32724.1 - 0.062 13.8 2.5 1.2 9.7 0.4 3.0 2 1 1 3 3 3 0 PQQ-like domain Nucleoporin_N PF08801.11 CDF32724.1 - 0.15 10.8 0.4 1.9 7.2 0.1 2.0 1 1 1 2 2 2 0 Nup133 N terminal like TIR_2 PF13676.6 CDF32725.1 - 2.3e-17 63.7 0.0 9.3e-17 61.7 0.0 2.1 2 0 0 2 2 2 1 TIR domain NB-ARC PF00931.22 CDF32725.1 - 2e-16 60.0 0.0 4.1e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF32725.1 - 2.6e-08 33.9 0.0 5.7e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 TIR domain AAA_22 PF13401.6 CDF32725.1 - 0.00055 20.2 0.1 0.0024 18.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIR-like PF10137.9 CDF32725.1 - 0.13 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain AAA_16 PF13191.6 CDF32725.1 - 0.17 12.3 0.4 0.55 10.6 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain APAF1_C PF17908.1 CDF32725.1 - 0.22 11.5 0.0 0.46 10.5 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain RT_RNaseH PF17917.1 CDF32726.1 - 5.6e-33 113.4 0.1 1.4e-32 112.1 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF32726.1 - 2.8e-32 110.7 0.0 5.6e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF32726.1 - 2.7e-18 66.3 0.0 6.1e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF32726.1 - 5.2e-16 58.5 0.0 1.2e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDF32726.1 - 6.3e-06 26.3 0.0 1.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Chromo PF00385.24 CDF32726.1 - 0.00093 19.1 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF32726.1 - 0.0045 16.7 0.1 0.02 14.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain BolA PF01722.18 CDF32731.1 - 3.8e-16 59.1 0.0 3.9e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein PB1 PF00564.24 CDF32734.1 - 2.2e-07 30.7 0.0 4.6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 PB1 domain PB1 PF00564.24 CDF32735.1 - 2.3e-09 37.1 0.0 7.3e-09 35.5 0.0 1.9 2 0 0 2 2 2 1 PB1 domain GATA PF00320.27 CDF32735.1 - 0.0022 17.6 7.8 0.051 13.2 1.6 2.6 2 0 0 2 2 2 2 GATA zinc finger CNDH2_C PF16858.5 CDF32735.1 - 0.074 12.9 2.7 0.1 12.4 2.7 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DNA_pol_phi PF04931.13 CDF32735.1 - 0.19 9.8 7.0 0.26 9.3 7.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-C3HC4_3 PF13920.6 CDF32735.1 - 0.59 10.0 8.3 0.22 11.4 0.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) NOA36 PF06524.12 CDF32735.1 - 1.4 8.2 5.7 2.3 7.4 5.7 1.3 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 CDF32735.1 - 2.8 7.6 12.6 5.8 6.6 12.6 1.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein ThiF PF00899.21 CDF32739.1 - 1.7e-46 158.6 0.0 2.3e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 CDF32739.1 - 0.0031 17.1 0.0 0.0059 16.2 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 CDF32739.1 - 0.025 13.9 0.6 0.062 12.7 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CDF32739.1 - 0.12 11.6 0.6 0.2 10.9 0.6 1.3 1 0 0 1 1 1 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 CDF32739.1 - 0.37 11.0 1.4 3.9 7.8 1.4 2.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Spec3 PF15795.5 CDF32743.1 - 6.2e-10 39.5 16.0 4.3e-08 33.6 16.0 2.3 1 1 0 1 1 1 1 Ectodermal ciliogenesis protein DUF1129 PF06570.11 CDF32743.1 - 0.11 12.0 0.3 0.14 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Shisa PF13908.6 CDF32743.1 - 0.14 12.4 5.5 0.19 11.9 5.1 1.5 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF485 PF04341.12 CDF32743.1 - 0.16 11.9 1.1 0.27 11.2 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 FA_desaturase PF00487.24 CDF32745.1 - 3.1e-26 92.8 22.1 3.1e-26 92.8 22.1 1.8 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 CDF32745.1 - 1.3e-07 31.0 0.3 2.3e-07 30.2 0.3 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) UDPGT PF00201.18 CDF32746.1 - 9.8e-06 24.6 0.0 1.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 CDF32746.1 - 0.0016 18.5 0.0 0.005 16.9 0.0 2.1 2 1 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain UPF0227 PF05728.12 CDF32746.1 - 0.081 12.9 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) GATA PF00320.27 CDF32747.1 - 2.9e-09 36.4 11.8 1.6e-06 27.6 5.8 2.6 2 0 0 2 2 2 2 GATA zinc finger ArfGap PF01412.18 CDF32747.1 - 9.4 6.3 7.2 0.38 10.8 0.7 2.0 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf HNH PF01844.23 CDF32747.1 - 9.8 6.4 9.4 6.6 7.0 0.1 3.7 4 0 0 4 4 4 0 HNH endonuclease Hint PF01079.20 CDF32748.1 - 8.8e-22 77.7 0.0 2.6e-21 76.2 0.0 1.8 1 1 0 1 1 1 1 Hint module YajC PF02699.15 CDF32748.1 - 0.22 11.4 0.1 0.58 10.1 0.1 1.7 2 0 0 2 2 2 0 Preprotein translocase subunit PIF1 PF05970.14 CDF32749.1 - 8.1e-101 337.8 0.0 2.1e-100 336.4 0.0 1.6 1 1 1 2 2 2 1 PIF1-like helicase AAA_30 PF13604.6 CDF32749.1 - 7.7e-14 51.8 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF32749.1 - 0.0074 16.6 0.0 0.021 15.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF32749.1 - 0.028 12.4 0.0 0.047 11.6 0.0 1.2 1 0 0 1 1 1 0 Helicase AAA_11 PF13086.6 CDF32749.1 - 0.053 13.3 0.1 8 6.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 CDF32749.1 - 0.09 12.6 0.1 0.27 11.1 0.1 1.8 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain LexA_DNA_bind PF01726.16 CDF32750.1 - 1.5e-25 88.7 0.0 2.5e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 LexA DNA binding domain Peptidase_S24 PF00717.23 CDF32750.1 - 8.8e-15 54.4 0.2 1.7e-14 53.5 0.2 1.5 1 0 0 1 1 1 1 Peptidase S24-like Sigma70_r4 PF04545.16 CDF32750.1 - 0.00055 19.4 0.1 0.0014 18.1 0.1 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_27 PF13463.6 CDF32750.1 - 0.0006 20.3 0.0 0.001 19.6 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 CDF32750.1 - 0.00079 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CDF32750.1 - 0.0028 17.2 0.1 0.0078 15.8 0.1 1.8 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 CDF32750.1 - 0.0044 16.9 0.0 0.0073 16.2 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_20 PF12840.7 CDF32750.1 - 0.021 14.9 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 CDF32750.1 - 0.037 13.8 0.1 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain Sigma70_r3 PF04539.16 CDF32750.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-70 region 3 TrmB PF01978.19 CDF32750.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB EcsB PF05975.12 CDF32750.1 - 0.17 10.7 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB DsrC PF04358.13 CDF32750.1 - 0.22 12.1 0.0 0.35 11.4 0.0 1.3 1 0 0 1 1 1 0 DsrC like protein BPL_LplA_LipB PF03099.19 CDF32751.1 - 8.3e-10 38.7 0.0 1.4e-08 34.7 0.0 2.1 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family WD40 PF00400.32 CDF32752.1 - 4.9e-07 30.4 0.5 0.014 16.2 0.0 3.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF32752.1 - 5.6e-06 26.6 0.0 0.19 12.0 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 CDF32752.1 - 0.019 14.9 0.4 1.6 8.8 0.0 3.6 4 0 0 4 4 4 0 PQQ enzyme repeat QWRF PF04484.12 CDF32752.1 - 0.18 11.5 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 QWRF family Frtz PF11768.8 CDF32752.1 - 0.29 9.4 0.0 0.42 8.9 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Ras PF00071.22 CDF32753.1 - 1.3e-55 187.5 0.3 1.5e-55 187.2 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF32753.1 - 5.4e-29 100.8 0.1 8.5e-29 100.2 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF32753.1 - 7.3e-10 38.6 0.0 8.5e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDF32753.1 - 2.9e-05 23.7 0.0 4.9e-05 22.9 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain NIF PF03031.18 CDF32755.1 - 3.6e-53 179.5 0.0 4.6e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RGS-like PF09128.11 CDF32755.1 - 0.061 13.0 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain RRM_1 PF00076.22 CDF32757.1 - 7.7e-16 57.7 0.1 1.5e-15 56.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNN_linker PF09050.10 CDF32757.1 - 0.053 13.3 0.2 0.14 11.9 0.2 1.8 1 0 0 1 1 1 0 Stannin unstructured linker Nop10p PF04135.12 CDF32758.1 - 8.1e-21 73.8 1.3 9.4e-21 73.6 1.3 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family NifU_N PF01592.16 CDF32759.1 - 1.1e-54 184.0 0.2 1.3e-54 183.8 0.2 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain RRM_1 PF00076.22 CDF32760.1 - 8.3e-16 57.6 0.1 1.5e-15 56.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNN_linker PF09050.10 CDF32760.1 - 0.056 13.2 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Stannin unstructured linker AMPK1_CBM PF16561.5 CDF32761.1 - 1.3e-28 99.0 0.1 7.6e-28 96.6 0.1 2.1 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 CDF32761.1 - 0.0023 18.1 1.6 0.0043 17.3 0.3 2.2 2 1 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain Cupin_3 PF05899.12 CDF32763.1 - 5.9e-25 86.8 0.1 9.5e-25 86.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 CDF32763.1 - 3.6e-07 30.0 0.1 8.7e-07 28.8 0.0 1.5 1 1 1 2 2 2 1 Ethanolamine utilisation protein EutQ Cupin_2 PF07883.11 CDF32763.1 - 0.00027 20.6 0.0 0.00047 19.8 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 CDF32763.1 - 0.0018 18.1 0.0 0.0031 17.2 0.0 1.4 1 1 0 1 1 1 1 Cupin ARD PF03079.14 CDF32763.1 - 0.13 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Pkinase PF00069.25 CDF32764.1 - 1.8e-67 227.5 0.0 2.5e-67 227.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32764.1 - 8.8e-47 159.6 0.0 1.3e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF32764.1 - 0.007 15.2 0.1 0.035 12.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 CDF32764.1 - 0.15 11.0 0.1 5.5 5.8 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain SARAF PF06682.12 CDF32765.1 - 6.5e-27 95.1 0.1 9.9e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Spt5-NGN PF03439.13 CDF32768.1 - 6.6e-16 58.0 0.0 1.6e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 CDF32768.1 - 1.8e-15 56.2 29.2 0.00075 19.4 1.4 7.2 8 0 0 8 8 8 6 KOW motif CTD PF12815.7 CDF32768.1 - 0.0002 21.8 3.9 0.0002 21.8 3.9 3.4 2 1 1 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 CDF32768.1 - 0.017 16.1 0.2 0.017 16.1 0.2 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal PA PF02225.22 CDF32768.1 - 0.11 12.5 0.1 0.41 10.7 0.1 1.9 1 0 0 1 1 1 0 PA domain CHD5 PF04420.14 CDF32770.1 - 3.5e-05 23.7 4.7 0.00024 21.0 4.7 2.1 1 1 0 1 1 1 1 CHD5-like protein ABC_tran_CTD PF16326.5 CDF32770.1 - 0.06 13.6 1.1 0.11 12.7 1.1 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain AAA PF00004.29 CDF32772.1 - 7.4e-14 52.3 0.0 1.8e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDF32772.1 - 1.3e-10 41.3 0.0 3.1e-09 36.8 0.0 2.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 CDF32772.1 - 2.9e-07 30.8 0.0 6.9e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain RuvB_N PF05496.12 CDF32772.1 - 8.2e-07 28.9 0.0 1.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF32772.1 - 4.6e-06 26.9 0.0 2.1e-05 24.8 0.0 2.1 2 1 0 2 2 1 1 AAA domain Rad17 PF03215.15 CDF32772.1 - 6.4e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CDF32772.1 - 6.4e-05 23.4 0.5 0.00055 20.4 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDF32772.1 - 0.00017 21.4 0.0 0.00043 20.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 CDF32772.1 - 0.00024 21.4 0.1 0.00069 19.9 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 CDF32772.1 - 0.0008 19.3 0.2 0.0045 16.8 0.0 2.2 2 1 0 3 3 3 1 AAA domain AAA_19 PF13245.6 CDF32772.1 - 0.0013 19.1 0.4 0.011 16.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CDF32772.1 - 0.003 16.8 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 CDF32772.1 - 0.0033 17.2 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CDF32772.1 - 0.019 15.0 0.0 0.24 11.4 0.0 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit DUF815 PF05673.13 CDF32772.1 - 0.052 12.7 0.0 0.09 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 CDF32772.1 - 0.059 12.8 2.4 0.15 11.4 0.0 2.6 3 1 1 4 4 3 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CDF32772.1 - 0.087 13.4 0.0 0.22 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDF32772.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CDF32772.1 - 0.14 12.5 0.0 0.46 10.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Malectin PF11721.8 CDF32774.1 - 1.3e-16 61.2 0.0 2.9e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Malectin domain TIG PF01833.24 CDF32774.1 - 9e-11 41.7 13.5 1.5e-07 31.3 0.4 3.6 3 0 0 3 3 3 2 IPT/TIG domain GSDH PF07995.11 CDF32774.1 - 4e-06 26.4 0.1 7.8e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase SoxZ PF08770.11 CDF32774.1 - 0.032 14.0 0.6 0.59 10.0 0.1 2.5 2 0 0 2 2 2 0 Sulphur oxidation protein SoxZ DUF5496 PF17600.2 CDF32774.1 - 0.071 13.2 0.1 51 4.0 0.0 3.8 4 0 0 4 4 4 0 Family of unknown function (DUF5496) BiPBP_C PF06832.12 CDF32774.1 - 0.13 12.3 0.0 0.38 10.8 0.0 1.8 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family Neocarzinostat PF00960.18 CDF32774.1 - 7 6.7 7.1 11 6.1 0.2 3.5 3 0 0 3 3 3 0 Neocarzinostatin family HTH_38 PF13936.6 CDF32775.1 - 2.8e-10 39.8 0.4 6.4e-10 38.6 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_1 PF11427.8 CDF32775.1 - 1.2e-09 37.8 0.1 2.2e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_32 PF13565.6 CDF32775.1 - 9.1e-06 26.2 1.6 0.00053 20.5 0.3 2.2 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDF32775.1 - 3.3e-05 23.8 0.9 0.012 15.6 0.2 2.7 1 1 1 2 2 2 2 Winged helix-turn helix HTH_28 PF13518.6 CDF32775.1 - 0.0014 18.8 2.1 0.035 14.2 0.2 2.3 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF32775.1 - 0.0044 16.8 0.3 0.36 10.7 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain UPF0122 PF04297.14 CDF32775.1 - 0.0066 16.7 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like Sigma70_r4_2 PF08281.12 CDF32775.1 - 0.0072 16.0 0.1 0.022 14.4 0.0 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_11 PF08279.12 CDF32775.1 - 0.0083 16.1 0.1 0.023 14.7 0.1 1.7 2 0 0 2 2 2 1 HTH domain TrmB PF01978.19 CDF32775.1 - 0.0087 15.9 0.1 1.5 8.7 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.13 CDF32775.1 - 0.011 15.3 0.8 4.4 7.0 0.2 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc3_2 PF01498.18 CDF32775.1 - 0.013 15.7 1.7 0.035 14.4 0.3 2.1 1 1 1 2 2 2 0 Transposase ArsR PF09824.9 CDF32775.1 - 0.014 15.0 1.2 1.2 8.7 0.1 2.1 2 0 0 2 2 2 0 ArsR transcriptional regulator HTH_5 PF01022.20 CDF32775.1 - 0.026 14.4 0.1 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 CDF32775.1 - 0.03 13.9 0.1 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding CABIT PF12736.7 CDF32775.1 - 0.06 12.6 0.3 1 8.6 0.1 2.0 2 0 0 2 2 2 0 Cell-cycle sustaining, positive selection, DUF2481 PF10654.9 CDF32775.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) TraH_2 PF06871.11 CDF32776.1 - 0.017 14.7 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 TraH_2 WD40 PF00400.32 CDF32779.1 - 5.6e-28 96.6 14.1 7.1e-08 33.0 0.2 5.8 4 0 0 4 4 4 4 WD domain, G-beta repeat NB-ARC PF00931.22 CDF32779.1 - 1.4e-13 50.6 0.0 2.6e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF32779.1 - 2.3e-08 34.2 0.4 0.48 10.7 0.0 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF32779.1 - 0.0029 17.2 11.0 0.0055 16.3 9.6 2.2 2 0 0 2 2 2 1 PQQ-like domain Nup160 PF11715.8 CDF32779.1 - 0.0073 15.0 0.3 2 7.0 0.0 3.0 1 1 2 3 3 3 1 Nucleoporin Nup120/160 WD40_like PF17005.5 CDF32779.1 - 0.011 15.0 0.0 6.1 6.1 0.0 3.4 4 0 0 4 4 4 0 WD40-like domain Me-amine-dh_H PF06433.11 CDF32779.1 - 0.015 14.2 0.1 0.11 11.3 0.1 2.1 1 1 1 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Peptidase_S9_N PF02897.15 CDF32779.1 - 0.046 12.5 1.5 0.52 9.0 0.1 2.8 1 1 2 3 3 3 0 Prolyl oligopeptidase, N-terminal beta-propeller domain PQQ_3 PF13570.6 CDF32779.1 - 0.061 13.8 0.9 12 6.6 0.1 3.6 3 0 0 3 3 3 0 PQQ-like domain AAA_22 PF13401.6 CDF32779.1 - 0.098 12.9 0.0 0.39 11.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain PTN13_u3 PF16599.5 CDF32779.1 - 0.14 12.2 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ HicA_toxin PF07927.12 CDF32782.1 - 0.084 12.9 0.0 0.089 12.8 0.0 1.2 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, PDZ_4 PF17816.1 CDF32784.1 - 0.05 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DDE_3 PF13358.6 CDF32785.1 - 3.3e-19 69.1 0.1 4.4e-19 68.7 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_S41 PF03572.18 CDF32787.1 - 1.2e-11 44.5 0.0 2.7e-11 43.3 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 PDZ_4 PF17816.1 CDF32787.1 - 0.03 14.7 0.0 0.076 13.4 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Lactamase_B PF00753.27 CDF32788.1 - 1.4e-21 77.5 0.1 2e-21 76.9 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF32788.1 - 6.8e-07 29.0 0.0 1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDF32788.1 - 0.014 15.3 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CDF32788.1 - 0.13 11.7 0.0 0.3 10.5 0.0 1.6 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Folate_carrier PF01770.18 CDF32789.1 - 0.12 11.1 0.0 0.13 11.0 0.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier ABC_tran_Xtn PF12848.7 CDF32793.1 - 0.1 12.6 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 ABC transporter Methyltransf_3 PF01596.17 CDF32795.1 - 6.1e-41 139.9 0.1 9.1e-41 139.4 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase DHQ_synthase PF01761.20 CDF32795.1 - 4.2e-07 29.4 0.0 8.6e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase Methyltransf_31 PF13847.6 CDF32795.1 - 1e-06 28.6 0.1 1.6e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CDF32795.1 - 1.5e-06 29.1 0.0 3.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDF32795.1 - 5.5e-06 26.1 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDF32795.1 - 1.2e-05 25.9 0.0 3.7e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDF32795.1 - 0.00032 20.5 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CDF32795.1 - 0.001 18.7 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Spermine_synth PF01564.17 CDF32795.1 - 0.002 17.6 0.1 0.0033 16.9 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain MutS_V PF00488.21 CDF32797.1 - 2.3e-59 200.6 0.1 8.4e-59 198.8 0.1 2.0 1 1 0 1 1 1 1 MutS domain V MutS_I PF01624.20 CDF32797.1 - 9.9e-31 106.3 0.2 1.9e-29 102.2 0.0 2.4 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.18 CDF32797.1 - 2.6e-24 86.5 1.4 1e-23 84.6 0.0 2.7 2 2 0 2 2 2 1 MutS domain III MutS_II PF05188.17 CDF32797.1 - 9.5e-11 42.1 0.3 2.9e-10 40.5 0.3 1.9 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CDF32797.1 - 0.00042 20.6 0.0 0.00097 19.4 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV XRN_M PF17846.1 CDF32798.1 - 0.01 14.8 0.1 0.016 14.2 0.1 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DAGK_acc PF00609.19 CDF32799.1 - 9.1e-35 120.3 0.0 1.2e-34 119.9 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 CDF32799.1 - 4.6e-24 84.4 0.0 6.7e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ribosomal_S5 PF00333.20 CDF32800.1 - 1.8e-29 101.5 1.1 3.7e-29 100.5 1.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CDF32800.1 - 3.5e-24 84.0 0.0 7e-24 83.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain AAA_5 PF07728.14 CDF32800.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FoP_duplication PF13865.6 CDF32800.1 - 1.5 9.4 13.3 3.3 8.3 13.3 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Branch PF02485.21 CDF32801.1 - 6.2e-29 101.2 0.6 1e-28 100.5 0.6 1.3 1 1 0 1 1 1 1 Core-2/I-Branching enzyme Mpp10 PF04006.12 CDF32807.1 - 0.21 10.0 3.5 0.28 9.6 3.5 1.1 1 0 0 1 1 1 0 Mpp10 protein bZIP_2 PF07716.15 CDF32807.1 - 0.26 11.4 15.4 0.47 10.6 15.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper SLT PF01464.20 CDF32808.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain KAR9 PF08580.10 CDF32809.1 - 2.3 6.6 3.1 2.5 6.5 3.1 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 KAR9 PF08580.10 CDF32811.1 - 2.3 6.6 3.1 2.5 6.5 3.1 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 PPR_2 PF13041.6 CDF32813.1 - 2e-33 114.3 0.1 2e-17 63.1 0.1 5.0 3 1 2 5 5 5 4 PPR repeat family PPR PF01535.20 CDF32813.1 - 4.9e-31 104.8 0.3 1.4e-10 40.7 0.1 4.7 5 0 0 5 5 5 4 PPR repeat PPR_1 PF12854.7 CDF32813.1 - 1.1e-25 88.9 0.1 1.9e-10 40.2 0.0 4.1 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 CDF32813.1 - 4.2e-19 68.4 0.0 1.6e-08 34.5 0.0 3.6 2 2 1 4 4 4 2 Pentatricopeptide repeat domain PPR_long PF17177.4 CDF32813.1 - 5.4e-14 52.1 0.0 7e-09 35.4 0.0 2.2 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 CDF32813.1 - 6.2e-07 29.7 5.0 0.58 11.1 0.0 4.6 3 2 2 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF32813.1 - 2.5e-06 27.1 0.2 3.9 7.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF32813.1 - 0.0012 19.3 1.3 1.8 9.2 0.1 3.2 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF32813.1 - 0.0079 16.2 2.0 14 6.1 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF32813.1 - 0.0084 16.4 0.5 2.2 8.7 0.1 3.1 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF32813.1 - 0.038 14.2 0.1 8 7.0 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF32813.1 - 0.039 14.6 0.7 1.4e+02 3.2 0.1 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat MNE1 PF13762.6 CDF32813.1 - 0.053 13.5 0.0 0.82 9.6 0.0 2.4 1 1 1 2 2 2 0 Mitochondrial splicing apparatus component RPN7 PF10602.9 CDF32813.1 - 0.064 13.0 0.4 1.9 8.2 0.1 2.7 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_4 PF07721.14 CDF32813.1 - 0.07 13.8 0.7 22 6.1 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDF32813.1 - 0.079 12.9 3.8 12 5.9 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CDF32813.1 - 0.087 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit DNA_pol3_gamma3 PF12169.8 CDF32813.1 - 0.09 12.7 0.1 4.7 7.1 0.0 2.5 2 1 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III ATP13 PF12921.7 CDF32813.1 - 0.091 12.6 0.0 22 4.9 0.0 2.9 1 1 2 3 3 3 0 Mitochondrial ATPase expression TPR_1 PF00515.28 CDF32813.1 - 0.15 11.9 2.2 15 5.6 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ANF_receptor PF01094.28 CDF32813.1 - 0.17 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Receptor family ligand binding region CCT PF06203.14 CDF32814.1 - 2.5e-14 53.1 13.7 3.7e-14 52.5 13.7 1.3 1 0 0 1 1 1 1 CCT motif FAM199X PF15814.5 CDF32814.1 - 0.014 14.5 1.9 0.018 14.1 1.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X Laminin_B PF00052.18 CDF32816.1 - 0.06 13.2 0.3 0.079 12.9 0.3 1.3 1 1 0 1 1 1 0 Laminin B (Domain IV) FKBP_N PF01346.18 CDF32816.1 - 0.24 12.4 9.2 0.94 10.5 9.2 2.1 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase ADIP PF11559.8 CDF32816.1 - 0.27 11.3 10.6 0.46 10.6 3.5 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding G-patch PF01585.23 CDF32819.1 - 3.8e-13 49.1 4.8 7.9e-13 48.1 4.8 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDF32819.1 - 8.8e-08 32.1 4.2 8.8e-08 32.1 4.2 2.2 3 0 0 3 3 3 1 G-patch domain CBM_20 PF00686.19 CDF32823.1 - 7.5e-09 35.4 0.0 1.6e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain ATG16 PF08614.11 CDF32823.1 - 0.00021 21.6 161.5 0.0037 17.5 22.6 9.7 2 2 7 10 10 10 7 Autophagy protein 16 (ATG16) DUF4988 PF16378.5 CDF32823.1 - 8.4 6.0 8.3 0.93 9.1 0.3 3.8 3 0 0 3 3 3 0 Domain of unknown function HTH_Tnp_Tc3_1 PF11427.8 CDF32824.1 - 1.3e-10 40.9 0.0 2.4e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF32824.1 - 4.7e-08 32.7 0.0 8.6e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF32824.1 - 0.00022 21.8 0.4 0.0018 18.9 0.2 2.0 1 1 1 2 2 2 1 Homeodomain-like domain TrmB PF01978.19 CDF32824.1 - 0.0032 17.3 0.2 1.4 8.9 0.0 2.2 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 CDF32824.1 - 0.0035 17.4 0.2 0.11 12.6 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 CDF32824.1 - 0.25 11.4 1.2 3.3 7.8 0.8 2.6 2 1 0 2 2 2 0 Winged helix-turn helix DDE_3 PF13358.6 CDF32825.1 - 1.6e-14 53.9 0.0 2.4e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF32825.1 - 2.3e-07 30.5 0.0 3.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF32825.1 - 2.7e-05 23.8 0.1 4.3e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF32825.1 - 0.00044 20.0 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 CDF32825.1 - 0.027 14.5 0.1 0.07 13.2 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn helix Terminase_5 PF06056.12 CDF32825.1 - 0.047 13.6 0.2 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_32 PF13565.6 CDF32825.1 - 0.057 14.0 1.4 8.9 7.0 0.3 2.7 1 1 1 2 2 2 0 Homeodomain-like domain His_Phos_1 PF00300.22 CDF32826.1 - 2.3e-06 27.4 0.0 4.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Rab5ip PF07019.12 CDF32827.1 - 6.1e-11 42.8 0.9 7.8e-11 42.4 0.9 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) PhoR PF11808.8 CDF32827.1 - 3.3 8.2 0.0 3.3 8.2 0.0 2.7 3 0 0 3 3 3 0 Phosphate regulon sensor protein PhoR DDE_3 PF13358.6 CDF32829.1 - 2.2e-17 63.2 0.0 5.6e-17 61.9 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF32829.1 - 1.6e-08 34.2 0.0 3.5e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF32829.1 - 1.9e-05 24.3 0.0 5.6e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF32829.1 - 2.1e-05 24.1 0.1 8.7e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CDF32829.1 - 0.052 13.2 0.1 0.51 10.0 0.1 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc3_2 PF01498.18 CDF32829.1 - 0.08 13.2 1.8 0.15 12.3 0.8 2.1 2 0 0 2 2 2 0 Transposase HTH_24 PF13412.6 CDF32829.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 CDF32830.1 - 0.06 13.5 0.4 0.22 11.7 0.4 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain PCSK9_C2 PF18464.1 CDF32831.1 - 0.044 13.8 2.3 0.058 13.4 2.3 1.2 1 0 0 1 1 1 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain rRNA_processing PF08524.11 CDF32833.1 - 1.2e-07 31.8 22.4 1.3e-07 31.7 22.4 1.0 1 0 0 1 1 1 1 rRNA processing DUF1003 PF06210.11 CDF32833.1 - 0.46 10.6 3.9 0.66 10.1 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) GDP_Man_Dehyd PF16363.5 CDF32834.1 - 9.9e-08 31.7 0.0 0.00012 21.6 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDF32834.1 - 1e-06 28.4 0.0 0.0038 16.7 0.0 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family Hint PF01079.20 CDF32836.1 - 5.1e-31 107.9 0.3 9.4e-31 107.0 0.3 1.4 1 1 0 1 1 1 1 Hint module PUA PF01472.20 CDF32836.1 - 0.0097 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 PUA domain Intein_splicing PF14890.6 CDF32836.1 - 0.028 14.4 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 Intein splicing domain PfkB PF00294.24 CDF32837.1 - 5.7e-68 229.4 0.2 6.7e-68 229.2 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CDF32837.1 - 0.042 13.2 0.0 0.083 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase LsmAD PF06741.13 CDF32838.1 - 1.3e-21 76.9 1.0 3e-21 75.7 1.0 1.6 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 CDF32838.1 - 1e-05 25.6 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 CDF32838.1 - 0.0045 16.6 2.6 1.2 9.0 0.6 2.8 1 1 1 2 2 2 2 Ataxin-2 C-terminal region PDCD2_C PF04194.13 CDF32839.1 - 7.9e-31 107.5 0.0 1.7e-30 106.4 0.0 1.6 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 CDF32839.1 - 3.8e-09 36.5 13.0 3.8e-09 36.5 13.0 3.3 3 1 0 3 3 3 1 MYND finger GDP_Man_Dehyd PF16363.5 CDF32840.1 - 4.2e-56 190.8 0.0 5.3e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDF32840.1 - 4.1e-52 177.0 0.0 5e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDF32840.1 - 2.4e-14 53.0 0.0 3.9e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDF32840.1 - 1.2e-12 47.6 0.0 8e-12 44.9 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDF32840.1 - 7.7e-10 38.3 0.0 1.2e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CDF32840.1 - 8.4e-08 31.9 0.0 4.4e-07 29.6 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDF32840.1 - 5.2e-07 29.7 0.0 9e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 CDF32840.1 - 1.9e-06 27.3 0.0 0.0014 17.9 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CDF32840.1 - 0.00049 20.0 0.0 0.00081 19.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding UDPG_MGDP_dh_N PF03721.14 CDF32840.1 - 0.0088 15.6 0.2 0.015 14.9 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.13 CDF32840.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.6 1 0 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.18 CDF32840.1 - 0.065 13.5 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DXP_synthase_N PF13292.6 CDF32843.1 - 8.8e-15 54.6 1.9 6.2e-12 45.3 0.0 2.9 2 2 1 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDF32843.1 - 5.9e-12 45.6 0.1 8.8e-12 45.1 0.1 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain EMP24_GP25L PF01105.24 CDF32844.1 - 1.7e-16 60.7 0.0 2.6e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RAI1 PF08652.11 CDF32845.1 - 3.7e-17 62.3 0.0 1.4e-16 60.4 0.0 2.0 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease CRAL_TRIO_2 PF13716.6 CDF32848.1 - 2.9e-12 46.9 0.0 3.5e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain TPT PF03151.16 CDF32849.1 - 4.8e-22 78.6 15.7 5.5e-22 78.5 15.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDF32849.1 - 1.5e-05 25.1 25.7 0.0071 16.5 9.9 2.3 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CDF32849.1 - 9.3e-05 21.8 19.1 0.00012 21.4 19.1 1.1 1 0 0 1 1 1 1 UAA transporter family DUF2976 PF11190.8 CDF32849.1 - 0.41 10.5 3.4 5.1 7.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) FA_desaturase PF00487.24 CDF32850.1 - 1.9e-18 67.2 21.7 1e-16 61.5 8.9 2.3 1 1 1 2 2 2 2 Fatty acid desaturase DUF3474 PF11960.8 CDF32850.1 - 0.00021 21.5 0.0 0.00047 20.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Ins134_P3_kin PF05770.11 CDF32853.1 - 4e-26 91.8 0.0 2.4e-20 72.9 0.0 2.2 2 0 0 2 2 2 2 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain RimK PF08443.11 CDF32853.1 - 0.0078 15.8 0.0 0.69 9.5 0.0 2.8 3 0 0 3 3 3 2 RimK-like ATP-grasp domain JmjC PF02373.22 CDF32854.1 - 1.1e-24 87.1 0.0 1.8e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase ABC_tran PF00005.27 CDF32855.1 - 1.7e-14 54.5 0.0 2.3e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CDF32855.1 - 8.1e-05 22.6 0.0 0.00011 22.2 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDF32855.1 - 0.00044 20.7 0.0 0.00064 20.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF32855.1 - 0.0011 18.7 0.0 0.0024 17.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CDF32855.1 - 0.0013 18.6 0.0 0.0016 18.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CDF32855.1 - 0.0047 17.2 0.0 0.0068 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDF32855.1 - 0.0054 16.8 0.0 0.0071 16.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CDF32855.1 - 0.0091 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_15 PF13175.6 CDF32855.1 - 0.012 15.4 0.0 0.014 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CDF32855.1 - 0.012 15.8 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CDF32855.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_7 PF12775.7 CDF32855.1 - 0.022 14.3 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 CDF32855.1 - 0.035 14.6 0.0 0.051 14.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF32855.1 - 0.05 13.3 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDF32855.1 - 0.064 13.5 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDF32855.1 - 0.19 11.8 0.0 0.27 11.2 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CDF32855.1 - 0.19 12.3 0.0 0.25 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CDF32856.1 - 8.3e-26 91.0 0.0 1.1e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDF32856.1 - 4.4e-10 39.5 0.5 6.9e-10 38.9 0.2 1.5 2 0 0 2 2 2 1 TIP49 AAA-lid domain TIP49 PF06068.13 CDF32857.1 - 1.4e-12 47.5 1.1 2e-12 47.0 1.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain AAA PF00004.29 CDF32857.1 - 0.027 14.9 0.0 0.34 11.3 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zincin_2 PF10103.9 CDF32857.1 - 0.054 12.8 0.0 0.08 12.2 0.0 1.2 1 0 0 1 1 1 0 Zincin-like metallopeptidase ATPase PF06745.13 CDF32857.1 - 0.14 11.5 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 CDF32857.1 - 0.16 11.6 0.0 0.37 10.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDF32857.1 - 0.18 11.1 0.1 0.33 10.2 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin DUF2075 PF09848.9 CDF32857.1 - 0.19 10.9 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IGFL PF14653.6 CDF32858.1 - 0.0077 16.2 0.1 2.4 8.2 0.1 3.1 3 0 0 3 3 3 2 Insulin growth factor-like family Ribosomal_L35Ae PF01247.18 CDF32861.1 - 2.7e-19 69.1 0.4 3e-19 69.0 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae NTR PF01759.21 CDF32861.1 - 0.013 15.3 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 UNC-6/NTR/C345C module RimM PF01782.18 CDF32861.1 - 0.1 12.8 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 RimM N-terminal domain An_peroxidase PF03098.15 CDF32862.1 - 5.5e-114 381.6 0.0 6.1e-114 381.5 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Cpn60_TCP1 PF00118.24 CDF32863.1 - 3.6e-155 517.3 8.5 4.5e-155 517.0 8.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Myb_DNA-binding PF00249.31 CDF32864.1 - 5.6e-28 96.9 1.6 2.4e-13 50.0 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF32864.1 - 1.4e-23 82.9 1.6 1.1e-14 54.3 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 CDF32864.1 - 0.00047 20.3 0.0 0.0013 18.8 0.0 1.8 1 0 0 1 1 1 1 Rap1 Myb domain DUF3934 PF13070.6 CDF32864.1 - 0.025 15.0 2.7 0.026 15.0 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3934) Myb_DNA-bind_4 PF13837.6 CDF32864.1 - 0.17 12.3 3.4 0.2 12.1 0.1 2.4 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 CDF32864.1 - 6.8 6.8 7.5 5.7 7.1 0.5 3.5 2 2 1 3 3 3 0 Myb/SANT-like DNA-binding domain UCH PF00443.29 CDF32869.1 - 1.7e-47 162.1 0.0 5.2e-47 160.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF32869.1 - 5.2e-09 36.1 7.3 4.5e-05 23.2 0.0 3.0 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Motile_Sperm PF00635.26 CDF32870.1 - 0.004 17.0 0.0 0.0076 16.1 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain NUMOD3 PF07460.11 CDF32871.1 - 1.9e-18 66.4 14.2 4.4e-14 52.4 4.8 3.6 3 0 0 3 3 3 3 NUMOD3 motif (2 copies) Drf_FH3 PF06367.16 CDF32871.1 - 0.052 13.1 0.1 0.084 12.5 0.1 1.3 1 0 0 1 1 1 0 Diaphanous FH3 Domain E2_bind PF08825.10 CDF32871.1 - 0.093 12.9 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 E2 binding domain AAA_13 PF13166.6 CDF32871.1 - 1.9 7.0 6.6 2.7 6.5 6.6 1.1 1 0 0 1 1 1 0 AAA domain Mito_carr PF00153.27 CDF32872.1 - 3.2e-56 187.2 6.1 3.3e-20 71.8 1.6 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Hrs_helical PF12210.8 CDF32872.1 - 0.11 13.1 0.0 9.1 6.9 0.1 2.5 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate PRR18 PF15671.5 CDF32872.1 - 0.56 10.1 7.3 0.69 9.7 6.1 1.7 2 0 0 2 2 2 0 Proline-rich protein family 18 PGAP1 PF07819.13 CDF32874.1 - 1.7e-08 34.5 0.0 3.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 PGAP1-like protein Abhydrolase_1 PF00561.20 CDF32874.1 - 2.9e-06 27.1 0.1 0.0022 17.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Palm_thioest PF02089.15 CDF32874.1 - 6.5e-06 26.2 0.0 1.2e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 CDF32874.1 - 1.7e-05 25.5 2.8 3.2e-05 24.6 2.8 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF32874.1 - 0.0015 17.9 0.0 0.49 9.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF676 PF05057.14 CDF32874.1 - 0.027 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF915 PF06028.11 CDF32874.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) SelK_SelG PF10961.8 CDF32875.1 - 2.6e-10 40.8 5.3 4.7e-10 39.9 5.3 1.4 1 0 0 1 1 1 1 Selenoprotein SelK_SelG tRNA-synt_1c PF00749.21 CDF32877.1 - 2.1e-97 325.8 0.0 2.8e-97 325.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CDF32877.1 - 1e-40 139.4 0.0 4.5e-40 137.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain ChitinaseA_N PF08329.10 CDF32877.1 - 0.026 14.2 0.0 0.06 13.0 0.0 1.5 1 0 0 1 1 1 0 Chitinase A, N-terminal domain tRNA_synt_1c_R1 PF04558.15 CDF32879.1 - 2.9e-25 89.2 0.2 8.2e-16 58.4 0.1 2.1 2 0 0 2 2 2 2 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 PF04557.15 CDF32879.1 - 0.0041 18.0 0.4 0.018 16.0 0.0 2.1 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Kinesin PF00225.23 CDF32880.1 - 1.9e-69 234.2 9.2 6.3e-65 219.3 0.0 3.9 2 2 1 4 4 4 2 Kinesin motor domain Microtub_bd PF16796.5 CDF32880.1 - 2.5e-54 183.3 0.1 9e-54 181.5 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding HAUS-augmin3 PF14932.6 CDF32880.1 - 1.5 8.4 42.2 2.3 7.7 17.5 3.8 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 DUF3584 PF12128.8 CDF32880.1 - 2.2 5.7 41.2 4.2 4.8 41.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Myosin_tail_1 PF01576.19 CDF32880.1 - 3.3 5.4 58.2 0.013 13.4 14.3 3.1 1 1 2 3 3 3 0 Myosin tail DUF1664 PF07889.12 CDF32880.1 - 3.8 7.6 24.6 0.35 10.9 2.4 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 CDF32880.1 - 4.6 5.0 32.9 0.9 7.4 11.8 2.2 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Mst1_SARAH PF11629.8 CDF32880.1 - 5.3 7.2 8.4 0.53 10.4 0.3 3.3 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 Spc7 PF08317.11 CDF32880.1 - 6.4 5.6 50.3 0.25 10.2 10.6 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein Bacillus_HBL PF05791.11 CDF32880.1 - 7 6.4 20.6 0.52 10.1 3.0 3.3 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Pkinase PF00069.25 CDF32881.1 - 2.1e-52 178.1 0.0 2.8e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32881.1 - 1.9e-22 79.8 0.0 2.6e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF32881.1 - 0.00048 20.1 0.2 0.023 14.6 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF32881.1 - 0.00051 19.4 0.3 0.00079 18.8 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF32881.1 - 0.0028 16.5 0.0 0.0037 16.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 CDF32881.1 - 0.052 13.1 0.1 0.078 12.5 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 CDF32881.1 - 0.07 12.1 0.1 0.1 11.6 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 CDF32881.1 - 0.089 12.4 0.1 0.16 11.5 0.1 1.4 1 1 0 1 1 1 0 RIO1 family EcKinase PF02958.20 CDF32881.1 - 0.11 11.8 0.1 0.6 9.4 0.0 1.8 1 1 1 2 2 2 0 Ecdysteroid kinase eIF3_subunit PF08597.10 CDF32882.1 - 4e-36 125.1 13.3 5.6e-36 124.7 13.3 1.2 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit zf-C2H2_jaz PF12171.8 CDF32883.1 - 0.0024 18.1 0.1 0.0041 17.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDF32883.1 - 0.0031 17.9 0.1 0.0053 17.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDF32883.1 - 0.1 13.0 0.1 0.1 13.0 0.1 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Paramyxo_ncap PF00973.19 CDF32883.1 - 4.2 6.2 6.1 8.1 5.2 6.1 1.4 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein TAFII28 PF04719.14 CDF32884.1 - 1.3e-24 86.1 0.1 2.4e-24 85.2 0.1 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CPSF100_C PF13299.6 CDF32884.1 - 1.1 9.5 7.8 2.8 8.1 7.8 1.8 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal WD40 PF00400.32 CDF32886.1 - 1.4e-19 70.1 11.0 2.8e-06 27.9 0.1 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CDF32886.1 - 1.2e-13 51.1 0.1 7.9e-13 48.5 0.0 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 CDF32886.1 - 2e-06 28.0 0.4 0.29 11.5 0.0 3.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF32886.1 - 0.00016 21.6 0.1 0.00086 19.2 0.1 2.2 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A NucS PF01939.16 CDF32886.1 - 0.02 14.3 0.2 0.053 12.9 0.0 1.7 2 0 0 2 2 2 0 Endonuclease NucS Frtz PF11768.8 CDF32886.1 - 0.05 11.9 0.0 0.089 11.1 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz FAM176 PF14851.6 CDF32886.1 - 0.12 12.0 0.6 0.3 10.7 0.6 1.6 1 0 0 1 1 1 0 FAM176 family DUF3824 PF12868.7 CDF32886.1 - 2.3 8.9 7.8 0.47 11.1 0.9 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Pkinase PF00069.25 CDF32887.1 - 2.4e-27 95.9 0.0 3.1e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32887.1 - 3.7e-23 82.1 0.0 6.6e-23 81.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Spt20 PF12090.8 CDF32890.1 - 2.7 7.5 0.0 2.7 7.5 0.0 5.4 4 1 1 5 5 5 0 Spt20 family DUF4218 PF13960.6 CDF32892.1 - 0.00027 20.5 0.0 0.0006 19.4 0.0 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4218) SelK_SelG PF10961.8 CDF32896.1 - 0.95 10.1 5.9 1.4 9.6 5.9 1.2 1 0 0 1 1 1 0 Selenoprotein SelK_SelG Flavin_Reduct PF01613.18 CDF32903.1 - 9.2e-07 29.0 0.2 4.2e-06 26.9 0.2 1.9 1 1 0 1 1 1 1 Flavin reductase like domain ANAPC4_WD40 PF12894.7 CDF32905.1 - 1.9e-14 53.7 5.9 0.059 13.7 0.1 8.0 6 3 2 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF32905.1 - 2.9e-08 34.3 19.6 0.073 14.0 0.0 8.3 8 1 0 8 8 8 2 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF32905.1 - 2.2e-06 27.4 16.8 0.00018 21.2 11.1 3.7 3 1 0 3 3 3 1 PQQ-like domain PQQ PF01011.21 CDF32905.1 - 0.00038 20.2 17.6 0.19 11.7 0.1 7.5 9 0 0 9 9 9 1 PQQ enzyme repeat eIF2A PF08662.11 CDF32905.1 - 0.0016 18.4 0.1 0.13 12.2 0.0 3.5 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CDF32905.1 - 0.0039 17.1 14.2 13 5.8 0.0 7.2 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 CDF32905.1 - 0.086 11.9 0.6 3.3 6.7 0.0 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1513) zf-CCHC_6 PF15288.6 CDF32906.1 - 0.38 10.6 2.8 1.3 8.9 0.1 2.4 1 1 1 2 2 2 0 Zinc knuckle ApbE PF02424.15 CDF32907.1 - 6.7e-38 130.7 0.1 2.3e-37 128.9 0.0 1.9 2 0 0 2 2 2 1 ApbE family Flavin_Reduct PF01613.18 CDF32907.1 - 0.013 15.5 1.1 0.038 14.0 0.0 2.2 3 0 0 3 3 3 0 Flavin reductase like domain Nic96 PF04097.14 CDF32910.1 - 8.3e-74 249.2 0.0 1.1e-73 248.8 0.0 1.0 1 0 0 1 1 1 1 Nup93/Nic96 SpoU_methylase PF00588.19 CDF32912.1 - 4.9e-12 46.2 0.0 5e-12 46.2 0.0 1.0 1 0 0 1 1 1 1 SpoU rRNA Methylase family Abhydrolase_1 PF00561.20 CDF32913.1 - 3.5e-19 69.5 0.0 5e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF32913.1 - 3.9e-11 44.0 0.1 4.8e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF32913.1 - 0.0064 15.8 0.0 0.0087 15.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 CDF32913.1 - 0.011 14.8 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) SIMPL PF04402.14 CDF32914.1 - 1.2e-42 146.7 3.6 1.3e-42 146.5 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Abhydrolase_1 PF00561.20 CDF32915.1 - 2e-06 27.6 0.0 4.7e-06 26.4 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold tRNA-synt_1d PF00750.19 CDF32915.1 - 0.21 10.5 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (R) SIMPL PF04402.14 CDF32916.1 - 2.2e-42 145.8 7.8 2.5e-42 145.6 7.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF541) rve PF00665.26 CDF32918.1 - 8.2e-21 74.4 0.0 1.7e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF32918.1 - 3.1e-16 59.2 0.0 5.5e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF32918.1 - 1.8e-10 40.5 0.0 3e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF32918.1 - 0.00079 19.2 1.5 0.0023 17.6 0.0 2.6 4 0 0 4 4 4 1 Integrase core domain zf-H2C2 PF09337.10 CDF32918.1 - 0.0011 19.2 0.0 0.0026 17.9 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Hydrolase_4 PF12146.8 CDF32934.1 - 0.036 13.3 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 IBR PF01485.21 CDF32935.1 - 0.0017 18.5 10.6 0.0028 17.8 10.6 1.4 1 1 0 1 1 1 1 IBR domain, a half RING-finger domain zf-B_box PF00643.24 CDF32935.1 - 0.01 15.9 3.3 0.01 15.9 3.3 1.9 2 0 0 2 2 2 0 B-box zinc finger DUF562 PF04763.12 CDF32936.1 - 0.26 10.7 0.0 0.3 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF562) DUF5567 PF17722.1 CDF32937.1 - 0.17 11.7 0.4 0.26 11.1 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5567) Glyco_hydro_31 PF01055.26 CDF32937.1 - 1.4 8.0 5.6 1.8 7.6 5.6 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 Pantoate_ligase PF02569.15 CDF32939.1 - 1.6e-81 273.4 0.0 1.8e-81 273.2 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase zf-4CXXC_R1 PF10497.9 CDF32941.1 - 0.0039 17.4 14.9 0.0075 16.5 14.9 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 bZIP_2 PF07716.15 CDF32942.1 - 0.0041 17.2 14.9 0.0063 16.6 14.3 1.7 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CDF32942.1 - 0.17 12.0 13.5 0.35 11.0 13.5 1.5 1 0 0 1 1 1 0 bZIP transcription factor AAA_12 PF13087.6 CDF32944.1 - 2.1e-58 197.2 0.0 4.9e-58 196.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDF32944.1 - 4.6e-56 190.5 0.1 4.6e-56 190.5 0.1 3.3 3 0 0 3 3 3 1 AAA domain SEN1_N PF12726.7 CDF32944.1 - 1.5e-14 53.3 0.0 3.1e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 SEN1 N terminal AAA_30 PF13604.6 CDF32944.1 - 3e-11 43.4 0.1 1.6e-05 24.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CDF32944.1 - 2.6e-08 34.3 0.0 1.4e-07 31.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain CENP-F_leu_zip PF10473.9 CDF32944.1 - 0.012 15.6 0.5 0.041 13.9 0.5 1.8 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_25 PF13481.6 CDF32944.1 - 0.025 14.1 0.0 0.069 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Cnn_1N PF07989.11 CDF32944.1 - 0.026 14.7 0.3 0.089 13.0 0.3 1.9 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 AAA_22 PF13401.6 CDF32944.1 - 0.03 14.6 0.0 5.2 7.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 CDF32944.1 - 0.04 13.8 0.0 0.095 12.5 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 CDF32944.1 - 0.056 12.7 0.0 6.5 5.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF4819 PF16090.5 CDF32944.1 - 0.11 12.6 0.2 4 7.6 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4819) AAA_16 PF13191.6 CDF32944.1 - 0.13 12.6 0.1 0.61 10.5 0.1 2.2 1 0 0 1 1 1 0 AAA ATPase domain LUC7 PF03194.15 CDF32949.1 - 6.3e-10 39.1 3.2 1.7e-09 37.7 3.2 1.8 1 1 0 1 1 1 1 LUC7 N_terminus Macoilin PF09726.9 CDF32949.1 - 0.29 9.6 4.7 0.37 9.3 4.7 1.1 1 0 0 1 1 1 0 Macoilin family Merozoite_SPAM PF07133.11 CDF32949.1 - 1.3 9.0 17.3 2.4 8.1 17.3 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) tRNA-synt_2b PF00587.25 CDF32951.1 - 3.8e-28 98.7 0.0 5.6e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CDF32951.1 - 4.8e-18 65.4 2.3 8.3e-18 64.6 2.3 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain TEX13 PF15186.6 CDF32951.1 - 0.16 11.7 1.1 0.29 10.8 1.1 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family AMP-binding PF00501.28 CDF32952.1 - 9.9e-85 284.7 0.3 1.3e-84 284.3 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDF32952.1 - 3.6e-22 79.1 0.6 9.9e-22 77.7 0.6 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CDF32952.1 - 8.6e-13 48.0 0.1 2e-12 46.8 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Memo PF01875.17 CDF32954.1 - 4.3e-39 134.3 0.0 4.8e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein MULE PF10551.9 CDF32954.1 - 0.12 12.8 0.0 0.38 11.2 0.0 1.8 2 0 0 2 2 2 0 MULE transposase domain PBS_linker_poly PF00427.21 CDF32956.1 - 1e-38 132.2 0.1 1.5e-38 131.7 0.1 1.1 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide Pkinase PF00069.25 CDF32958.1 - 1.5e-76 257.3 0.0 1.9e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF32958.1 - 6.9e-31 107.5 0.0 1e-30 106.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF32958.1 - 1e-05 24.7 0.0 1.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF32958.1 - 4e-05 23.1 0.0 0.00012 21.5 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CDF32958.1 - 0.031 13.4 0.1 0.049 12.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Yippee-Mis18 PF03226.14 CDF32959.1 - 1.1e-14 54.4 0.2 1.3e-14 54.3 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CDF32959.1 - 0.0043 17.3 0.4 0.0069 16.6 0.4 1.3 1 1 0 1 1 1 1 C-terminal domain of RIG-I DZR PF12773.7 CDF32959.1 - 0.027 14.5 0.0 0.047 13.7 0.0 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 CDF32959.1 - 0.081 12.4 1.0 7.9 6.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-FLZ PF04570.14 CDF32959.1 - 0.11 12.0 0.4 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 zinc-finger of the FCS-type, C2-C2 Peptidase_C78 PF07910.13 CDF32960.1 - 3.5e-46 157.4 0.0 5e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 CDF32960.1 - 0.012 15.0 0.4 0.13 11.7 0.3 2.4 2 1 1 3 3 3 0 Peptidase family C54 PBP PF01161.20 CDF32961.1 - 6.5e-09 36.2 0.3 5.9e-08 33.1 0.0 2.3 2 0 0 2 2 2 1 Phosphatidylethanolamine-binding protein Aa_trans PF01490.18 CDF32965.1 - 2e-10 39.9 8.3 2.5e-10 39.7 8.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CDF32965.1 - 1.3e-06 27.7 8.8 1.6e-06 27.4 8.8 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family SPC12 PF06645.13 CDF32965.1 - 0.35 11.0 7.5 0.55 10.4 2.2 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) GRDP-like PF07173.12 CDF32966.1 - 1.3e-35 123.1 3.4 4.7e-29 101.9 1.1 2.5 2 0 0 2 2 2 2 Glycine-rich domain-containing protein-like Anti-TRAP PF15777.5 CDF32967.1 - 0.14 12.2 0.4 0.41 10.6 0.4 1.9 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-TFIIB PF13453.6 CDF32967.1 - 0.26 10.6 1.8 0.7 9.3 1.8 1.8 1 0 0 1 1 1 0 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.12 CDF32967.1 - 0.33 10.5 2.6 0.72 9.4 2.6 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Sulfotransfer_1 PF00685.27 CDF32968.1 - 6.5e-22 78.3 0.0 1.1e-21 77.5 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDF32968.1 - 0.0014 19.0 0.0 0.49 10.7 0.0 2.8 1 1 1 2 2 2 2 Sulfotransferase family PPR_2 PF13041.6 CDF32969.1 - 1.4e-05 25.2 0.0 0.024 14.8 0.0 3.8 3 1 1 4 4 4 2 PPR repeat family TPR_14 PF13428.6 CDF32969.1 - 0.003 18.2 0.2 6.7 7.8 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat PPR_3 PF13812.6 CDF32969.1 - 0.013 15.5 0.0 0.16 12.1 0.0 2.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.20 CDF32969.1 - 0.79 10.1 6.5 51 4.4 0.1 5.0 6 0 0 6 6 6 0 PPR repeat Fer4_14 PF13394.6 CDF32971.1 - 2.6e-12 46.9 0.0 8.2e-12 45.3 0.0 1.8 1 1 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 CDF32971.1 - 1.8e-10 41.5 0.0 2.5e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDF32971.1 - 9.9e-10 38.8 0.0 1.3e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain TnsE_C PF18623.1 CDF32971.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 TnsE C-terminal domain AMMECR1 PF01871.17 CDF32973.1 - 8.7e-45 152.3 0.0 9.9e-45 152.1 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 S1 PF00575.23 CDF32975.1 - 1.6e-19 70.0 0.2 2.1e-19 69.7 0.2 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNase_II_C_S1 PF18614.1 CDF32975.1 - 0.022 14.7 1.1 0.075 13.0 0.0 2.1 2 0 0 2 2 2 0 RNase II-type exonuclease C-terminal S1 domain EXOSC1 PF10447.9 CDF32975.1 - 0.12 13.0 0.4 4.4 8.0 0.1 2.2 1 1 1 2 2 2 0 Exosome component EXOSC1/CSL4 TrkA_C PF02080.21 CDF32975.1 - 0.12 12.2 0.5 12 5.8 0.1 2.4 2 0 0 2 2 2 0 TrkA-C domain Cullin PF00888.22 CDF32977.1 - 4.2e-45 154.5 5.1 2.3e-44 152.0 5.1 1.9 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CDF32977.1 - 2.1e-20 72.5 0.2 4.3e-20 71.5 0.2 1.6 1 0 0 1 1 1 1 Cullin protein neddylation domain Methyltransf_3 PF01596.17 CDF32981.1 - 1e-45 155.5 0.5 1.6e-45 154.9 0.5 1.3 1 0 0 1 1 1 1 O-methyltransferase DHQ_synthase PF01761.20 CDF32981.1 - 6.2e-41 140.3 0.0 1.1e-40 139.4 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase Methyltransf_24 PF13578.6 CDF32981.1 - 1.5e-09 38.8 0.1 4e-09 37.5 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDF32981.1 - 9.9e-07 28.6 0.1 1.8e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CDF32981.1 - 8.1e-06 25.7 0.3 1.4e-05 24.9 0.3 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDF32981.1 - 1.5e-05 24.9 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Spermine_synth PF01564.17 CDF32981.1 - 0.00011 21.7 1.4 0.00084 18.8 0.3 2.3 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_25 PF13649.6 CDF32981.1 - 0.0006 20.5 0.1 0.0015 19.2 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDF32981.1 - 0.037 13.3 0.0 0.06 12.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase GCD14 PF08704.10 CDF32981.1 - 0.18 11.5 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MFS_1 PF07690.16 CDF32983.1 - 3.9e-10 39.2 13.7 5e-10 38.8 13.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily SipA_VBS PF17985.1 CDF32983.1 - 0.15 12.0 0.4 0.47 10.4 0.4 1.8 1 0 0 1 1 1 0 SipA vinculin binding site PsaL PF02605.15 CDF32984.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI DNase-RNase PF02577.14 CDF32989.1 - 1.1e-22 80.0 0.0 1.4e-20 73.2 0.0 2.2 2 0 0 2 2 2 2 Bifunctional nuclease UVR PF02151.19 CDF32989.1 - 1.8e-08 33.9 5.5 0.0014 18.3 0.0 2.4 2 0 0 2 2 2 2 UvrB/uvrC motif zf-Tim10_DDP PF02953.15 CDF32990.1 - 5.7e-05 22.7 0.6 7.9e-05 22.2 0.6 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TRAPP PF04051.16 CDF32991.1 - 5.1e-33 113.9 0.0 5.9e-33 113.6 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PAP2_C PF14360.6 CDF32992.1 - 0.0019 18.7 1.4 0.002 18.6 1.4 1.1 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF4186 PF13811.6 CDF32992.1 - 0.1 12.6 0.1 0.1 12.6 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4186) S-AdoMet_synt_C PF02773.16 CDF32993.1 - 1.1e-62 210.1 0.0 1.5e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDF32993.1 - 0.074 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, central domain Spt20 PF12090.8 CDF32994.1 - 0.052 13.2 1.2 0.057 13.0 1.2 1.0 1 0 0 1 1 1 0 Spt20 family Patched PF02460.18 CDF32996.1 - 6.1e-86 289.2 0.4 7.6e-86 288.9 0.4 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDF32996.1 - 1.5e-34 119.0 16.0 1.3e-33 116.0 1.5 2.3 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CDF32996.1 - 1.3e-06 27.6 27.0 6.9e-05 21.9 2.4 3.0 3 0 0 3 3 3 2 MMPL family ACR_tran PF00873.19 CDF32996.1 - 7.8 4.0 23.3 2.5 5.6 14.3 2.3 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Nrap PF03813.14 CDF32997.1 - 5.1e-29 101.3 0.1 8.5e-29 100.6 0.1 1.3 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D4 PF17405.2 CDF32997.1 - 4.3e-21 75.3 0.0 8.9e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 CDF32997.1 - 3.2e-16 59.5 0.0 4.9e-15 55.7 0.0 2.4 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 CDF32997.1 - 1.1e-11 45.0 0.2 3.1e-11 43.6 0.2 1.8 1 1 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 CDF32997.1 - 1.4e-09 38.3 0.0 4.7e-09 36.6 0.0 1.9 2 0 0 2 2 2 1 Nrap protein domain 6 RT_RNaseH PF17917.1 CDF33000.1 - 1.4e-18 67.1 0.1 3.6e-18 65.8 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF33000.1 - 2.1e-18 66.2 0.0 7.4e-08 32.3 0.0 2.7 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF33000.1 - 7.4e-12 45.2 1.8 1.6e-11 44.1 1.8 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF33000.1 - 2.9e-06 27.5 0.0 6.3e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CDF33000.1 - 0.0019 17.7 0.0 0.24 10.9 0.0 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF33000.1 - 0.002 18.3 0.0 0.006 16.8 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger Glutaredoxin PF00462.24 CDF33001.1 - 1.2e-06 28.6 0.1 2.1e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 CDF33001.1 - 4.3e-06 27.0 0.1 7.9e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Ribosomal_L39 PF00832.20 CDF33001.1 - 0.0034 17.0 0.1 0.0061 16.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal L39 protein GST_N_2 PF13409.6 CDF33001.1 - 0.013 15.8 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 CDF33001.1 - 0.097 13.4 0.0 0.18 12.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_N PF02798.20 CDF33001.1 - 0.12 12.7 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain RrnaAD PF00398.20 CDF33004.1 - 3.1e-44 151.0 0.0 4.2e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 CDF33004.1 - 0.0053 16.3 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CDF33004.1 - 0.049 13.1 0.0 0.11 11.9 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Herpes_TK PF00693.18 CDF33004.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Thymidine kinase from herpesvirus Methyltransf_25 PF13649.6 CDF33004.1 - 0.12 13.1 0.0 0.26 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 CDF33004.1 - 0.17 11.1 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain GIDA PF01134.22 CDF33005.1 - 8.2e-151 502.5 0.0 1.2e-150 502.0 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDF33005.1 - 6.6e-64 216.0 1.2 9.3e-64 215.5 1.2 1.2 1 0 0 1 1 1 1 GidA associated domain HI0933_like PF03486.14 CDF33005.1 - 3.6e-05 22.6 0.4 0.074 11.7 0.1 3.1 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 CDF33005.1 - 0.0001 21.5 2.1 0.0009 18.4 0.3 2.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CDF33005.1 - 0.0004 19.7 0.2 0.0011 18.3 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDF33005.1 - 0.00061 19.2 2.3 0.0026 17.2 2.2 2.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase DAO PF01266.24 CDF33005.1 - 0.005 16.5 0.4 1.8 8.1 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDF33005.1 - 0.15 12.7 0.2 0.7 10.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Neuropeptide_S PF14993.6 CDF33005.1 - 0.15 11.9 0.1 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 Neuropeptide S precursor protein DUF4291 PF14124.6 CDF33006.1 - 3e-58 196.7 0.8 3.7e-58 196.4 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) TPR_9 PF13371.6 CDF33006.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 CDF33007.1 - 2.6e-36 125.0 0.0 3.7e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDF33007.1 - 1.5e-18 67.5 0.0 2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CDF33007.1 - 8e-07 28.7 0.0 1.3e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 CDF33007.1 - 0.0017 17.9 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CDF33007.1 - 0.0076 16.7 0.0 0.028 14.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Patatin PF01734.22 CDF33008.1 - 4.5e-11 43.3 0.1 8.3e-10 39.2 0.1 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase MeaB PF03308.16 CDF33010.1 - 0.076 12.0 0.0 0.083 11.9 0.0 1.0 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SCP1201-deam PF14428.6 CDF33010.1 - 0.14 12.0 0.0 0.14 12.0 0.0 1.0 1 0 0 1 1 1 0 SCP1.201-like deaminase DUF3852 PF12963.7 CDF33011.1 - 0.022 15.1 0.0 0.05 13.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) YGGT PF02325.17 CDF33013.1 - 4.6e-07 30.2 6.3 5.4e-07 29.9 6.3 1.1 1 0 0 1 1 1 1 YGGT family Serpin PF00079.20 CDF33015.1 - 0.053 12.8 0.7 0.21 10.8 0.9 1.8 2 0 0 2 2 2 0 Serpin (serine protease inhibitor) MS_channel PF00924.18 CDF33015.1 - 2.5 7.6 4.5 4.4 6.8 4.5 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel Z1 PF10593.9 CDF33015.1 - 3.5 7.1 6.6 5.6 6.4 5.8 1.8 2 0 0 2 2 2 0 Z1 domain Spore_II_R PF09551.10 CDF33015.1 - 9.1 6.8 13.3 9.2 6.7 10.2 2.5 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) Sulfotransfer_2 PF03567.14 CDF33016.1 - 0.03 14.2 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family DDE_Tnp_4 PF13359.6 CDF33017.1 - 2.4e-13 50.1 0.0 3.2e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Pollen_allerg_2 PF01620.16 CDF33018.1 - 0.14 12.3 0.5 0.26 11.5 0.1 1.6 2 0 0 2 2 2 0 Ribonuclease (pollen allergen) PIF1 PF05970.14 CDF33021.1 - 4.1e-94 315.7 0.0 6.1e-94 315.2 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF33021.1 - 1.3e-52 178.8 0.1 3.1e-52 177.6 0.0 1.7 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF33021.1 - 9.5e-07 28.7 0.0 1.7e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain VWA PF00092.28 CDF33027.1 - 6.4e-10 39.6 0.0 8.6e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CDF33027.1 - 9.6e-07 29.4 0.0 2.2e-06 28.3 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF1194 PF06707.11 CDF33027.1 - 0.00042 19.6 0.0 0.34 10.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1194) VWA PF00092.28 CDF33028.1 - 1.7e-12 48.0 0.1 2.2e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1194 PF06707.11 CDF33028.1 - 8.9e-07 28.3 0.0 0.0062 15.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1194) Fe-ADH_2 PF13685.6 CDF33028.1 - 3.3e-05 23.7 0.6 0.00013 21.8 0.2 2.0 1 1 1 2 2 2 1 Iron-containing alcohol dehydrogenase VWA_2 PF13519.6 CDF33028.1 - 4.7e-05 24.0 0.0 8.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 CDF33028.1 - 0.00077 19.4 0.0 0.0044 17.0 0.0 2.2 3 0 0 3 3 3 1 von Willebrand factor type A domain EF-hand_5 PF13202.6 CDF33028.1 - 0.18 11.4 0.0 0.44 10.1 0.0 1.6 1 0 0 1 1 1 0 EF hand Trypsin PF00089.26 CDF33030.1 - 1.7e-92 309.2 0.0 1.5e-34 119.7 0.0 3.1 3 0 0 3 3 3 3 Trypsin DUF1986 PF09342.11 CDF33030.1 - 9.5e-08 32.4 0.7 0.069 13.5 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF1986) PFK PF00365.20 CDF33036.1 - 1.6e-06 27.7 0.0 1.7e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 Phosphofructokinase TetR PF13972.6 CDF33037.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial transcriptional repressor Pkinase_Tyr PF07714.17 CDF33038.1 - 2.8e-58 197.2 0.0 3.8e-58 196.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF33038.1 - 3e-53 180.9 0.0 5.2e-53 180.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TIR_2 PF13676.6 CDF33038.1 - 3e-09 37.5 0.0 7.4e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF33038.1 - 0.0046 16.8 0.0 0.0077 16.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain Seipin PF06775.14 CDF33038.1 - 0.12 12.5 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative adipose-regulatory protein (Seipin) ABC_tran PF00005.27 CDF33040.1 - 1.7e-35 122.5 0.0 2.6e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDF33040.1 - 2.4e-15 56.9 0.6 3.2e-15 56.5 0.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDF33040.1 - 1e-05 25.1 0.2 0.00039 19.9 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CDF33040.1 - 7.6e-05 22.1 0.1 0.00018 20.9 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 CDF33040.1 - 0.00017 21.8 0.1 0.0011 19.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF33040.1 - 0.0032 17.9 1.5 0.009 16.4 1.5 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF33040.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 CDF33040.1 - 0.013 15.2 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 CDF33040.1 - 0.013 15.4 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_ATPase PF09818.9 CDF33040.1 - 0.014 14.2 0.1 0.025 13.4 0.1 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CDF33040.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 CDF33040.1 - 0.02 15.1 0.7 0.22 11.8 0.7 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CDF33040.1 - 0.022 14.7 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CDF33040.1 - 0.022 13.9 0.0 0.026 13.7 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 CDF33040.1 - 0.023 14.5 0.2 1.3 8.8 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDF33040.1 - 0.027 14.2 2.9 0.36 10.5 2.9 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDF33040.1 - 0.064 13.5 0.5 0.17 12.1 0.3 1.9 1 1 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.17 CDF33041.1 - 3.7e-61 206.7 0.0 5.2e-61 206.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF33041.1 - 1.8e-52 178.3 0.0 2.9e-52 177.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TIR_2 PF13676.6 CDF33041.1 - 5.4e-10 39.9 0.0 1.2e-09 38.8 0.0 1.6 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF33041.1 - 0.0088 15.9 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain Beach PF02138.18 CDF33042.1 - 4.4e-94 314.9 0.0 7.2e-94 314.2 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 CDF33042.1 - 0.0031 17.6 0.0 0.68 10.1 0.0 3.1 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 CDF33042.1 - 0.1 13.5 4.5 1.7 9.7 0.0 4.5 4 0 0 4 4 4 0 WD domain, G-beta repeat WD40_like PF17005.5 CDF33042.1 - 0.22 10.8 0.2 1.7 7.9 0.1 2.0 2 0 0 2 2 2 0 WD40-like domain HABP4_PAI-RBP1 PF04774.15 CDF33044.1 - 0.018 15.9 1.4 0.018 15.9 1.4 2.0 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family DUF543 PF04418.12 CDF33045.1 - 1e-16 60.7 0.8 1.1e-16 60.5 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) mTERF PF02536.14 CDF33046.1 - 1.8e-34 119.1 0.0 4.5e-23 81.6 0.0 2.7 1 1 2 3 3 3 3 mTERF SWIRM-assoc_2 PF16496.5 CDF33047.1 - 3.7e-44 151.3 0.0 8.4e-44 150.1 0.0 1.5 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 CDF33047.1 - 7.6e-26 90.3 0.8 3.4e-25 88.2 0.2 2.5 3 0 0 3 3 3 1 SWIRM domain Myb_DNA-binding PF00249.31 CDF33047.1 - 1.7e-09 37.7 0.0 5.1e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF33047.1 - 4.4e-09 36.4 1.7 1.5e-05 25.2 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain ZZ PF00569.17 CDF33047.1 - 2.9e-06 27.0 7.5 2.9e-06 27.0 7.5 2.0 2 0 0 2 2 2 1 Zinc finger, ZZ type SWIRM-assoc_1 PF16495.5 CDF33047.1 - 0.008 16.1 0.2 0.02 14.8 0.2 1.7 1 0 0 1 1 1 1 SWIRM-associated region 1 Zn-ribbon_8 PF09723.10 CDF33047.1 - 4.3 7.5 5.0 11 6.2 5.0 1.7 1 0 0 1 1 1 0 Zinc ribbon domain DUF3449 PF11931.8 CDF33048.1 - 3.7e-64 215.9 0.4 8.1e-64 214.8 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 CDF33048.1 - 1.9e-17 63.5 0.2 3.4e-17 62.7 0.2 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Telomere_Sde2_2 PF13297.6 CDF33048.1 - 8.1e-09 35.0 0.8 2.3e-08 33.6 0.3 1.9 2 0 0 2 2 2 1 Telomere stability C-terminal SF3a60_bindingd PF12108.8 CDF33048.1 - 2.3e-05 24.2 0.0 4.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain Nha1_C PF08619.10 CDF33048.1 - 0.11 11.6 0.1 0.2 10.9 0.1 1.4 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF5390 PF17365.2 CDF33048.1 - 0.14 12.4 0.2 0.33 11.2 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5390) PGM_PMM_I PF02878.16 CDF33049.1 - 3.9e-17 62.2 0.0 1e-07 31.8 0.0 3.0 1 1 2 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 CDF33049.1 - 2.2e-09 37.3 1.1 8.3e-09 35.5 1.1 2.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 CDF33049.1 - 2.5e-07 30.9 1.2 7.7e-06 26.1 1.2 2.4 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDF33049.1 - 0.00041 20.9 0.0 0.0021 18.6 0.0 2.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Pantoate_transf PF02548.15 CDF33050.1 - 3.4e-103 344.5 1.3 4e-103 344.3 1.3 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 CDF33050.1 - 0.00018 21.0 1.5 0.0004 19.9 1.5 1.7 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Rib_5-P_isom_A PF06026.14 CDF33050.1 - 0.025 14.2 0.5 0.18 11.4 0.0 2.1 2 0 0 2 2 2 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) NanE PF04131.14 CDF33050.1 - 0.22 10.7 1.4 1 8.5 0.1 2.3 3 0 0 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase zf-RING_2 PF13639.6 CDF33052.1 - 7.1e-09 35.9 10.1 7.1e-09 35.9 10.1 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 CDF33052.1 - 2.1e-06 27.5 7.6 4e-06 26.6 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF33052.1 - 2.2e-06 27.4 7.2 4.6e-06 26.4 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF33052.1 - 0.00013 22.0 7.6 0.00027 20.9 7.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDF33052.1 - 0.005 16.6 8.3 0.013 15.4 8.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF33052.1 - 0.0067 16.7 7.5 0.0067 16.7 7.5 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDF33052.1 - 0.013 15.2 8.2 0.032 14.0 8.2 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 CDF33052.1 - 0.016 15.2 8.2 0.03 14.3 8.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 CDF33052.1 - 0.029 14.4 4.1 0.076 13.1 4.1 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 CDF33052.1 - 0.065 13.1 1.0 0.17 11.8 1.0 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 CDF33052.1 - 0.079 12.8 8.1 0.16 11.8 8.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 CDF33052.1 - 0.84 9.3 6.2 2.2 8.0 6.2 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 CDF33052.1 - 0.96 9.7 5.5 3.6 7.8 5.5 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CDF33052.1 - 6.7 6.6 8.0 13 5.7 8.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Aminotran_1_2 PF00155.21 CDF33053.1 - 5.8e-20 71.8 0.0 3.9e-19 69.1 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Histidinol_dh PF00815.20 CDF33054.1 - 7.1e-140 466.6 1.8 8.6e-140 466.3 1.8 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase DUF21 PF01595.20 CDF33055.1 - 5.4e-27 94.6 0.0 9e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CDF33055.1 - 2.2e-06 28.0 0.8 0.034 14.6 0.1 2.7 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 CDF33055.1 - 0.00046 20.2 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Sel1 PF08238.12 CDF33057.1 - 9e-35 118.3 13.4 6.1e-06 26.7 0.1 8.5 9 0 0 9 9 9 6 Sel1 repeat TIR_2 PF13676.6 CDF33057.1 - 6.3e-10 39.7 0.0 3.1e-09 37.5 0.0 2.2 3 0 0 3 3 2 1 TIR domain TPR_17 PF13431.6 CDF33057.1 - 2.6e-08 33.7 0.2 2.6 8.6 0.0 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat Roc PF08477.13 CDF33057.1 - 1.8e-06 28.2 0.0 0.00074 19.7 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TPR_16 PF13432.6 CDF33057.1 - 0.00017 22.2 8.9 0.016 15.9 0.1 4.8 2 1 4 6 6 6 1 Tetratricopeptide repeat TIR PF01582.20 CDF33057.1 - 0.00017 21.4 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 TIR domain COR PF16095.5 CDF33057.1 - 0.00039 20.3 0.0 0.0007 19.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Ras PF00071.22 CDF33057.1 - 0.0023 17.5 0.0 0.14 11.7 0.0 2.5 2 0 0 2 2 2 1 Ras family TPR_14 PF13428.6 CDF33057.1 - 0.0059 17.3 12.8 1.3 10.1 0.1 6.1 5 2 3 8 8 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33057.1 - 0.0069 16.9 1.6 3.3 8.3 0.0 4.2 4 1 1 5 5 4 1 Tetratricopeptide repeat G-alpha PF00503.20 CDF33057.1 - 0.13 11.4 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit TPR_2 PF07719.17 CDF33057.1 - 0.47 10.7 11.8 3.4 8.0 0.0 7.0 9 0 0 9 9 9 0 Tetratricopeptide repeat ACOX PF01756.19 CDF33062.1 - 0.041 13.4 0.0 0.1 12.1 0.0 1.6 2 0 0 2 2 2 0 Acyl-CoA oxidase CDH PF02611.15 CDF33065.1 - 0.0095 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase Sel1 PF08238.12 CDF33066.1 - 3e-116 377.2 20.7 1.7e-05 25.3 0.0 19.2 19 0 0 19 19 19 18 Sel1 repeat TPR_17 PF13431.6 CDF33066.1 - 1.9e-31 106.1 3.7 6.4 7.4 0.0 18.5 17 3 0 17 17 17 9 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33066.1 - 3.6e-22 78.7 21.0 2.9 8.6 0.2 16.0 7 4 11 18 18 18 3 Tetratricopeptide repeat TIR_2 PF13676.6 CDF33066.1 - 1.6e-15 57.7 0.0 3.8e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF33066.1 - 3.7e-07 30.1 0.0 7.6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain TPR_7 PF13176.6 CDF33066.1 - 8.7e-06 25.4 42.5 9.1 6.6 0.2 17.3 14 6 5 19 19 19 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33066.1 - 5.7e-05 23.6 22.3 2.9 8.9 0.6 13.9 16 2 2 18 18 18 1 Tetratricopeptide repeat Synaptobrevin PF00957.21 CDF33066.1 - 0.00025 20.8 1.2 44 4.0 0.0 8.0 9 2 2 11 11 11 0 Synaptobrevin HetR_C PF18460.1 CDF33066.1 - 0.04 13.8 1.4 0.72 9.8 0.2 3.8 3 1 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain Phage_Gp19 PF09355.10 CDF33066.1 - 1.2 9.6 6.0 14 6.1 0.1 4.7 5 0 0 5 5 5 0 Phage protein Gp19/Gp15/Gp42 Sel1 PF08238.12 CDF33068.1 - 1.6e-06 28.6 0.0 0.0025 18.4 0.0 2.4 2 0 0 2 2 2 2 Sel1 repeat HetR_C PF18460.1 CDF33068.1 - 0.032 14.2 0.6 0.13 12.2 0.2 2.0 1 1 1 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain TPR_7 PF13176.6 CDF33068.1 - 0.043 13.9 0.6 0.63 10.2 0.3 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33068.1 - 0.07 14.0 0.5 0.15 12.9 0.5 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Sel1 PF08238.12 CDF33072.1 - 5.8e-14 52.2 0.3 0.0027 18.3 0.0 3.4 3 0 0 3 3 3 3 Sel1 repeat HetR_C PF18460.1 CDF33072.1 - 0.002 18.0 1.0 0.036 14.0 0.1 2.1 1 1 1 2 2 2 1 Heterocyst differentiation regulator C-terminal Hood domain TPR_7 PF13176.6 CDF33072.1 - 0.0026 17.7 3.7 0.66 10.1 0.2 3.8 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33072.1 - 0.017 15.6 2.5 0.89 10.1 0.6 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33072.1 - 0.019 15.8 1.5 0.16 12.8 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF33072.1 - 0.71 10.6 4.5 6.9 7.5 0.1 3.5 2 2 1 3 3 3 0 Tetratricopeptide repeat LDB19 PF13002.7 CDF33073.1 - 0.08 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Arrestin_N terminal like Lactamase_B PF00753.27 CDF33079.1 - 0.00089 19.3 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF33079.1 - 0.0045 16.5 0.1 0.0073 15.8 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PB1 PF00564.24 CDF33080.1 - 3.4e-11 42.9 0.2 8.3e-11 41.7 0.2 1.6 1 0 0 1 1 1 1 PB1 domain FYVE_2 PF02318.16 CDF33080.1 - 0.59 10.4 7.0 1.1 9.5 1.1 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger HypA PF01155.19 CDF33080.1 - 0.86 9.7 4.4 4.9 7.2 0.4 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 CDF33080.1 - 4.8 7.3 10.8 7.6 6.7 0.6 3.2 2 1 0 2 2 2 0 Double zinc ribbon MMS1_N PF10433.9 CDF33081.1 - 2.2e-89 300.3 0.0 3.2e-89 299.8 0.0 1.1 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CDF33081.1 - 2.7e-45 155.1 0.0 1.9e-44 152.3 0.0 2.4 2 1 0 2 2 2 1 CPSF A subunit region GFO_IDH_MocA PF01408.22 CDF33082.1 - 1.9e-18 67.4 0.1 2.9e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDF33082.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 CDF33082.1 - 0.038 14.4 0.0 0.077 13.4 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain AMP-binding PF00501.28 CDF33083.1 - 8.9e-74 248.6 1.0 7.4e-38 130.2 0.1 2.2 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CDF33083.1 - 3.8e-06 27.8 2.3 8.1e-06 26.7 0.6 2.4 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 CDF33084.1 - 5.8e-79 265.7 0.2 7.9e-79 265.2 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDF33084.1 - 9.6e-06 26.5 0.6 9.6e-06 26.5 0.6 2.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Methyltransf_22 PF13383.6 CDF33086.1 - 6.3e-12 45.6 0.3 1.9e-11 44.0 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_21 PF05050.12 CDF33086.1 - 4.3e-05 23.6 0.0 8.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain WD40 PF00400.32 CDF33088.1 - 4.9e-61 201.2 50.4 5.9e-09 36.4 0.5 9.7 9 0 0 9 9 9 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33088.1 - 5e-17 62.0 16.9 0.12 12.7 0.1 9.2 2 1 8 10 10 9 8 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF33088.1 - 1.9e-15 56.7 0.0 3.3e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Nup160 PF11715.8 CDF33088.1 - 0.00039 19.2 19.3 4.5 5.8 0.0 8.2 4 3 3 9 9 9 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF33088.1 - 0.00089 18.3 0.9 27 3.6 0.0 5.9 1 1 7 8 8 8 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF33088.1 - 0.0084 15.5 0.0 9.2 5.5 0.0 4.6 2 2 3 5 5 5 1 WD40-like domain AAA_22 PF13401.6 CDF33088.1 - 0.031 14.5 0.0 0.085 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain PQQ PF01011.21 CDF33088.1 - 0.062 13.3 0.0 2.5e+02 1.9 0.0 5.1 6 0 0 6 6 6 0 PQQ enzyme repeat PQQ_3 PF13570.6 CDF33088.1 - 0.097 13.2 32.0 6 7.5 1.4 8.6 3 2 6 9 9 9 0 PQQ-like domain Nucleoporin_N PF08801.11 CDF33088.1 - 0.28 9.9 4.4 15 4.2 0.1 4.4 2 1 2 4 4 4 0 Nup133 N terminal like Peptidase_S9_N PF02897.15 CDF33088.1 - 4.3 6.0 8.1 23 3.6 0.2 4.2 3 1 1 4 4 4 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DDE_3 PF13358.6 CDF33089.1 - 1.7e-08 34.3 0.0 2.5e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease YjeF_N PF03853.15 CDF33090.1 - 1.2e-22 80.7 0.0 1.9e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus SLT PF01464.20 CDF33091.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain DUF3138 PF11336.8 CDF33093.1 - 0.5 8.9 2.0 0.75 8.3 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Sel1 PF08238.12 CDF33095.1 - 1.1e-06 29.1 0.0 0.0076 16.9 0.0 3.4 3 0 0 3 3 3 2 Sel1 repeat Anoctamin PF04547.12 CDF33096.1 - 2e-24 86.2 0.0 5.4e-24 84.9 0.0 1.5 1 1 0 1 1 1 1 Calcium-activated chloride channel BAG PF02179.16 CDF33101.1 - 3.9e-07 30.4 0.5 1.3e-06 28.7 0.1 2.1 2 1 0 2 2 2 1 BAG domain Ubiquitin_5 PF18037.1 CDF33101.1 - 0.0054 17.1 1.2 0.011 16.1 0.8 1.7 2 0 0 2 2 2 1 Ubiquitin-like domain PDZ_2 PF13180.6 CDF33101.1 - 0.0078 16.5 0.1 0.016 15.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Peptidase_Prp PF04327.12 CDF33101.1 - 0.0085 16.3 0.4 0.2 11.9 0.2 2.4 1 1 1 2 2 2 1 Cysteine protease Prp DUF3450 PF11932.8 CDF33101.1 - 0.034 13.4 0.3 0.063 12.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ubiquitin PF00240.23 CDF33101.1 - 0.04 13.7 0.7 0.089 12.6 0.7 1.6 1 0 0 1 1 1 0 Ubiquitin family Med30 PF11315.8 CDF33101.1 - 0.058 13.6 0.5 1.2 9.3 1.0 2.2 1 1 1 2 2 2 0 Mediator complex subunit 30 Cep57_CLD_2 PF14197.6 CDF33101.1 - 0.89 9.7 6.1 4.8 7.4 0.2 2.9 2 1 0 3 3 3 0 Centrosome localisation domain of PPC89 Nop16 PF09420.10 CDF33103.1 - 6.4e-20 72.1 6.6 6.1e-16 59.1 2.3 2.1 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 HTH_32 PF13565.6 CDF33103.1 - 0.071 13.7 0.2 0.19 12.3 0.2 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Transket_pyr PF02779.24 CDF33104.1 - 3.4e-38 131.1 0.0 4.8e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CDF33104.1 - 1.3e-14 54.0 1.7 1.1e-11 44.5 0.0 3.2 3 1 1 4 4 4 2 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 CDF33104.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain T2SSF PF00482.23 CDF33105.1 - 0.1 12.6 1.3 0.17 11.8 0.5 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F ABC_tran PF00005.27 CDF33106.1 - 1.1e-43 149.0 0.0 1.6e-20 74.0 0.0 2.6 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDF33106.1 - 1.3e-22 79.7 1.4 2.3e-22 78.8 1.4 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF33106.1 - 2.5e-18 67.0 1.6 0.00091 19.1 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF33106.1 - 9.1e-10 38.3 0.5 0.15 11.5 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDF33106.1 - 1.8e-07 31.8 1.8 0.054 14.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 CDF33106.1 - 3e-07 30.5 0.4 0.00082 19.3 0.1 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_29 PF13555.6 CDF33106.1 - 3.6e-07 29.8 0.2 0.0051 16.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF33106.1 - 3.7e-06 27.4 0.0 0.065 13.6 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CDF33106.1 - 9.2e-06 25.7 0.0 0.025 14.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 CDF33106.1 - 1.4e-05 25.4 0.0 0.015 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDF33106.1 - 1.8e-05 25.0 0.0 0.058 13.7 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CDF33106.1 - 2.9e-05 24.0 2.2 0.091 12.4 0.1 3.1 4 1 1 5 5 4 2 AAA ATPase domain AAA_33 PF13671.6 CDF33106.1 - 3.4e-05 24.0 0.0 0.32 11.1 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 CDF33106.1 - 4.4e-05 23.5 0.0 0.26 11.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CDF33106.1 - 8.5e-05 22.5 0.0 0.34 10.8 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.6 CDF33106.1 - 0.00014 22.4 0.0 0.23 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDF33106.1 - 0.00025 21.4 0.2 0.79 10.1 0.0 3.0 2 1 0 2 2 2 1 RNA helicase AAA PF00004.29 CDF33106.1 - 0.0004 20.8 0.0 2.6 8.5 0.1 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDF33106.1 - 0.0018 18.0 0.0 1.5 8.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.14 CDF33106.1 - 0.0023 17.9 0.1 4.5 7.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 CDF33106.1 - 0.0042 17.5 0.0 5.2 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CDF33106.1 - 0.0047 17.0 2.3 1.4 8.9 0.1 3.3 2 1 1 3 3 3 1 Dynamin family PRK PF00485.18 CDF33106.1 - 0.0048 16.7 0.0 0.55 9.9 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 CDF33106.1 - 0.0053 16.7 0.1 0.9 9.4 0.0 2.7 3 0 0 3 3 2 1 Rad17 P-loop domain AAA_30 PF13604.6 CDF33106.1 - 0.011 15.5 0.0 2.3 7.9 0.0 3.2 3 1 0 3 3 2 0 AAA domain AAA_27 PF13514.6 CDF33106.1 - 0.012 15.2 1.3 1 8.9 0.0 2.9 3 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CDF33106.1 - 0.015 14.9 0.0 4.3 6.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 CDF33106.1 - 0.016 15.1 0.1 11 5.8 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea MeaB PF03308.16 CDF33106.1 - 0.026 13.5 0.0 9.2 5.2 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 CDF33106.1 - 0.026 13.7 0.1 1.5 7.9 0.0 2.4 2 1 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 CDF33106.1 - 0.027 14.0 0.0 0.83 9.1 0.0 2.4 3 0 0 3 3 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 CDF33106.1 - 0.031 13.5 0.0 0.8 8.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 CDF33106.1 - 0.035 14.3 0.0 3.2 8.0 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 CDF33106.1 - 0.043 13.0 0.0 0.85 8.7 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain dNK PF01712.19 CDF33106.1 - 0.049 13.5 0.0 4.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase TsaE PF02367.17 CDF33106.1 - 0.062 13.3 0.0 5.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MukB PF04310.12 CDF33106.1 - 0.064 13.1 0.1 8.4 6.1 0.0 2.9 3 0 0 3 3 3 0 MukB N-terminal DUF87 PF01935.17 CDF33106.1 - 0.079 13.0 5.5 2 8.5 0.0 3.3 3 1 1 4 4 3 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 CDF33106.1 - 0.088 12.1 0.2 10 5.4 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 CDF33106.1 - 0.089 11.8 0.0 0.36 9.9 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein Septin PF00735.18 CDF33106.1 - 0.11 11.8 0.0 8 5.7 0.0 2.3 2 0 0 2 2 2 0 Septin SRP54 PF00448.22 CDF33106.1 - 0.12 12.0 0.0 4.4 6.9 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 CDF33106.1 - 0.14 12.1 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 NTPase cobW PF02492.19 CDF33106.1 - 0.14 11.8 0.1 1.3 8.5 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP-synt_ab PF00006.25 CDF33106.1 - 0.17 11.6 0.0 0.86 9.2 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain WD40 PF00400.32 CDF33107.1 - 8.5e-31 105.5 15.0 2.2e-08 34.6 0.2 10.6 11 0 0 11 11 11 4 WD domain, G-beta repeat Utp12 PF04003.12 CDF33107.1 - 9.1e-14 51.7 0.3 1.8e-13 50.7 0.3 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 CDF33107.1 - 8.3e-08 32.4 0.1 0.31 11.4 0.0 6.4 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF33107.1 - 0.0038 16.6 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain DUF5046 PF16465.5 CDF33107.1 - 0.045 13.2 0.4 7.3 5.9 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) Nup160 PF11715.8 CDF33107.1 - 0.066 11.8 0.2 10 4.6 0.0 3.7 4 1 1 5 5 5 0 Nucleoporin Nup120/160 LPMO_10 PF03067.15 CDF33108.1 - 3e-23 83.5 0.9 4.2e-23 83.0 0.9 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Ldl_recept_a PF00057.18 CDF33108.1 - 0.046 14.0 5.6 0.32 11.2 5.6 2.5 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A Pyr_redox_2 PF07992.14 CDF33109.1 - 9.8e-38 130.0 0.2 8.6e-32 110.5 0.0 2.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF33109.1 - 2.9e-08 34.2 0.0 5.7e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HSP33 PF01430.19 CDF33111.1 - 1.5e-59 201.6 0.0 7.5e-58 196.0 0.0 2.0 2 0 0 2 2 2 2 Hsp33 protein YokU PF14122.6 CDF33111.1 - 0.25 11.3 0.3 0.52 10.3 0.1 1.6 2 0 0 2 2 2 0 YokU-like protein, putative antitoxin COPIIcoated_ERV PF07970.12 CDF33112.1 - 7.7e-68 228.6 0.0 9.6e-68 228.3 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CDF33112.1 - 2.6e-22 79.0 0.5 4.4e-22 78.2 0.0 1.6 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Inositol_P PF00459.25 CDF33113.1 - 1.6e-28 100.0 0.3 6e-28 98.1 0.3 1.7 1 1 0 1 1 1 1 Inositol monophosphatase family Pro_isomerase PF00160.21 CDF33115.1 - 5.8e-32 111.2 0.0 1.1e-31 110.2 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Birna_VP4 PF01768.16 CDF33115.1 - 0.074 12.8 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Birnavirus VP4 protein APH PF01636.23 CDF33118.1 - 1.1e-10 41.9 0.3 5.8e-10 39.5 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 CDF33118.1 - 0.046 12.6 0.0 0.069 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EcKinase PF02958.20 CDF33118.1 - 0.079 12.3 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Ecdysteroid kinase Ribosomal_S4e PF00900.20 CDF33120.1 - 1.2e-30 105.3 0.6 2.6e-30 104.1 0.6 1.6 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.12 CDF33120.1 - 2.1e-21 75.7 7.8 2.1e-21 75.7 7.8 1.9 2 0 0 2 2 2 1 RS4NT (NUC023) domain 40S_S4_C PF16121.5 CDF33120.1 - 2.1e-20 72.1 0.1 3.5e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 CDF33120.1 - 1.1e-07 31.5 0.0 2.2e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 CDF33120.1 - 0.034 14.1 0.1 0.034 14.1 0.1 3.1 4 0 0 4 4 4 0 KOW motif PP2C PF00481.21 CDF33122.1 - 1e-42 146.5 0.0 1.6e-42 145.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CDF33122.1 - 1.9e-05 24.4 1.2 4.2e-05 23.3 1.1 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C DUF1376 PF07120.11 CDF33122.1 - 0.041 14.2 0.2 13 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1376) Med3 PF11593.8 CDF33122.1 - 6.8 5.8 5.1 9.5 5.3 5.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Mito_carr PF00153.27 CDF33125.1 - 4.1e-65 215.7 1.7 3.4e-23 81.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3764 PF12594.8 CDF33125.1 - 0.15 12.1 0.0 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) Glyco_tran_28_C PF04101.16 CDF33127.1 - 5.1e-06 26.6 0.0 9.5e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Epimerase_2 PF02350.19 CDF33127.1 - 0.00092 18.2 0.0 0.0019 17.1 0.0 1.5 2 0 0 2 2 2 1 UDP-N-acetylglucosamine 2-epimerase Glycos_transf_1 PF00534.20 CDF33127.1 - 0.013 15.1 0.1 0.032 13.8 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 SET PF00856.28 CDF33129.1 - 4e-22 79.4 0.0 4e-22 79.4 0.0 3.0 2 1 0 2 2 2 1 SET domain RT_RNaseH PF17917.1 CDF33132.1 - 1.3e-35 121.8 0.0 2.4e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF33132.1 - 1.4e-33 114.9 0.0 2.2e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF33132.1 - 1.2e-13 50.9 0.1 2.4e-13 50.0 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Peptidase_S24 PF00717.23 CDF33136.1 - 1.6e-12 47.2 0.2 2.5e-12 46.6 0.2 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CDF33136.1 - 7.5e-12 45.2 0.0 1.5e-11 44.3 0.0 1.4 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 SURF1 PF02104.15 CDF33137.1 - 1.7e-38 132.6 0.0 2.2e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 SURF1 family EAP30 PF04157.16 CDF33139.1 - 5.8e-45 153.4 0.0 6.5e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family DUF3007 PF11460.8 CDF33140.1 - 3.8e-25 88.0 0.2 5e-25 87.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3007) DHQS PF01959.16 CDF33141.1 - 1.1e-101 340.3 0.0 1.7e-101 339.7 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase II Methyltr_RsmB-F PF01189.17 CDF33141.1 - 0.064 12.9 0.0 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Amdase PF17645.1 CDF33141.1 - 0.094 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Arylmalonate decarboxylase PEPcase PF00311.17 CDF33143.1 - 6.9e-267 887.6 0.0 8.4e-267 887.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 CDF33143.1 - 1.9e-05 23.4 0.0 4.5e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 Phosphoenolpyruvate carboxylase MerR-DNA-bind PF09278.11 CDF33143.1 - 0.026 15.1 0.2 0.82 10.3 0.2 2.9 2 0 0 2 2 2 0 MerR, DNA binding COX1 PF00115.20 CDF33150.1 - 9e-06 24.8 0.3 9.3e-06 24.7 0.3 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I F-box PF00646.33 CDF33152.1 - 0.00013 21.8 0.1 0.00033 20.5 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CDF33152.1 - 0.0043 16.9 0.1 0.01 15.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like PRP3 PF08572.10 CDF33153.1 - 1e-57 195.4 16.1 1.9e-57 194.6 16.1 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 CDF33153.1 - 4.5e-41 140.4 0.5 4.5e-41 140.4 0.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) SOUL PF04832.12 CDF33155.1 - 4.6e-06 26.9 0.0 3.4e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 SOUL heme-binding protein ALG3 PF05208.13 CDF33156.1 - 4.3e-125 417.9 15.1 5.6e-125 417.5 15.1 1.1 1 0 0 1 1 1 1 ALG3 protein Mannosyl_trans PF05007.13 CDF33156.1 - 0.00082 19.3 14.5 0.001 19.0 9.1 3.1 1 1 1 2 2 2 1 Mannosyltransferase (PIG-M) Pkinase PF00069.25 CDF33157.1 - 5.8e-06 25.9 0.0 9.7e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain UCH PF00443.29 CDF33158.1 - 1.8e-37 129.3 0.0 3.1e-37 128.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CDF33158.1 - 2.1e-20 72.2 0.0 5.5e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 Variant UBP zinc finger UBA PF00627.31 CDF33158.1 - 1.9e-18 66.0 0.4 1.7e-09 37.4 0.1 2.5 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.19 CDF33158.1 - 4.8e-08 33.2 0.0 1.5e-07 31.7 0.0 1.8 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CDF33158.1 - 7.9e-07 29.0 0.0 0.00065 19.4 0.0 3.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UBA_5 PF16577.5 CDF33158.1 - 0.12 12.5 0.0 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 UBA domain SNase PF00565.17 CDF33161.1 - 1e-19 71.0 1.2 4.7e-19 68.9 0.7 2.1 2 0 0 2 2 2 1 Staphylococcal nuclease homologue ATP-synt_10 PF05176.14 CDF33162.1 - 3e-20 72.6 0.0 3.5e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein NUMOD3 PF07460.11 CDF33163.1 - 1.5e-09 37.9 7.0 3.7e-06 27.1 0.2 4.0 2 1 2 4 4 4 3 NUMOD3 motif (2 copies) Drc1-Sld2 PF11719.8 CDF33163.1 - 1.9e-07 31.0 0.7 0.011 15.3 0.0 2.7 2 1 0 2 2 2 2 DNA replication and checkpoint protein ACOX PF01756.19 CDF33165.1 - 3.9e-15 55.9 0.0 6.9e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 CDF33165.1 - 5.6e-13 48.9 0.0 1.1e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CDF33165.1 - 9.8e-07 29.1 0.0 2.1e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 CDF33165.1 - 1.3e-06 29.0 0.1 2.6e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_N PF02771.16 CDF33165.1 - 0.026 15.2 0.0 0.086 13.5 0.0 1.9 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain GYF_2 PF14237.6 CDF33165.1 - 0.026 14.3 0.1 0.068 13.0 0.1 1.7 1 0 0 1 1 1 0 GYF domain 2 ACOX PF01756.19 CDF33166.1 - 3.9e-15 55.9 0.0 6.9e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 CDF33166.1 - 5.6e-13 48.9 0.0 1.1e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CDF33166.1 - 9.8e-07 29.1 0.0 2.1e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 CDF33166.1 - 1.3e-06 29.0 0.1 2.6e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_N PF02771.16 CDF33166.1 - 0.026 15.2 0.0 0.086 13.5 0.0 1.9 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain GYF_2 PF14237.6 CDF33166.1 - 0.026 14.3 0.1 0.068 13.0 0.1 1.7 1 0 0 1 1 1 0 GYF domain 2 RNase_PH PF01138.21 CDF33169.1 - 5.1e-33 114.4 0.1 7.5e-33 113.8 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF33169.1 - 9.3e-11 41.6 0.0 1.8e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SMC_N PF02463.19 CDF33171.1 - 2.8e-65 219.8 0.0 5.3e-65 218.9 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDF33171.1 - 2.4e-26 92.3 0.0 1.2e-25 90.1 0.0 2.3 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 CDF33171.1 - 6.9e-16 58.9 2.9 2.3e-08 34.2 0.0 3.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 CDF33171.1 - 1.4e-12 48.0 5.7 2.3e-05 24.4 0.0 3.2 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDF33171.1 - 1e-08 36.0 22.5 1e-08 36.0 22.5 5.2 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CDF33171.1 - 0.00027 20.6 0.0 0.00062 19.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 CDF33171.1 - 0.00058 18.8 8.5 0.00058 18.8 8.5 6.7 2 2 4 7 7 7 1 Spc7 kinetochore protein ABC_tran PF00005.27 CDF33171.1 - 0.89 10.1 13.4 6.7 7.2 1.0 4.9 2 2 1 3 3 3 0 ABC transporter DUF2009 PF09418.10 CDF33171.1 - 2.8 6.9 12.9 0.11 11.6 1.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2009) Peptidase_M41 PF01434.18 CDF33172.1 - 1.2e-60 204.7 0.0 1.8e-60 204.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CDF33172.1 - 1.6e-41 141.8 0.0 2.7e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF33172.1 - 6.5e-12 45.1 0.3 1.6e-11 43.8 0.3 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 CDF33172.1 - 3.1e-07 30.7 0.0 8.2e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 CDF33172.1 - 8.5e-05 22.6 0.0 0.0003 20.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF33172.1 - 0.00043 20.6 0.0 0.1 12.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF33172.1 - 0.0025 18.2 0.2 0.069 13.5 0.1 2.5 1 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 CDF33172.1 - 0.0056 15.9 0.0 0.0096 15.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 CDF33172.1 - 0.02 14.6 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDF33172.1 - 0.037 14.1 0.0 0.13 12.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 CDF33172.1 - 0.078 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDF33172.1 - 0.092 12.1 0.3 0.24 10.8 0.2 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDF33172.1 - 0.18 12.0 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Transport_MerF PF11431.8 CDF33177.1 - 0.092 12.6 0.4 0.092 12.6 0.4 2.3 2 0 0 2 2 2 0 Membrane transport protein MerF S-AdoMet_synt_C PF02773.16 CDF33180.1 - 2.8e-61 205.5 0.0 3.9e-61 205.1 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain Pkinase PF00069.25 CDF33185.1 - 4.5e-43 147.5 0.0 8.3e-43 146.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33185.1 - 5e-29 101.4 0.0 8.9e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF33185.1 - 0.039 13.3 0.1 0.072 12.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 CDF33185.1 - 0.071 13.3 0.1 0.25 11.5 0.1 1.8 1 1 0 1 1 1 0 ABC1 family DEAD PF00270.29 CDF33186.1 - 2.1e-15 56.9 0.0 2.6e-14 53.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF33186.1 - 3.3e-15 56.4 0.0 1.3e-14 54.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TRCF PF03461.15 CDF33186.1 - 9.8e-15 54.7 0.0 2.5e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 TRCF domain CarD_CdnL_TRCF PF02559.16 CDF33186.1 - 1.1e-12 48.5 0.0 1.7e-11 44.7 0.0 2.9 4 0 0 4 4 4 1 CarD-like/TRCF domain ResIII PF04851.15 CDF33186.1 - 1.3e-09 38.3 0.0 5.2e-09 36.3 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3638 PF12340.8 CDF33186.1 - 0.017 14.4 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_30 PF13604.6 CDF33186.1 - 0.052 13.3 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDF33186.1 - 0.12 12.3 0.0 0.49 10.4 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_membrane_2 PF06472.15 CDF33188.1 - 3.8e-69 233.1 0.0 5.1e-69 232.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDF33188.1 - 2.5e-19 70.1 0.0 6.1e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF33188.1 - 0.0003 20.7 0.0 0.00049 20.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDF33188.1 - 0.00035 21.0 0.1 0.002 18.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 CDF33188.1 - 0.00098 18.6 0.0 0.045 13.2 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDF33188.1 - 0.006 17.1 0.0 0.013 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF33188.1 - 0.0066 16.2 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CDF33188.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CDF33188.1 - 0.074 12.8 0.3 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 CDF33188.1 - 0.092 12.3 0.0 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDF33188.1 - 0.11 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.21 CDF33188.1 - 0.11 11.9 0.2 2.1 7.7 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 CDF33188.1 - 0.16 11.9 0.0 0.52 10.2 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase Carb_anhydrase PF00194.21 CDF33189.1 - 6.6e-24 84.8 0.0 5.8e-14 52.2 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic-type carbonic anhydrase DnaJ_C PF01556.18 CDF33190.1 - 5.5e-33 114.1 0.0 7.7e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDF33190.1 - 4.7e-26 90.7 0.9 8.3e-26 89.9 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDF33190.1 - 1.1e-08 35.3 13.7 2e-08 34.5 13.7 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CDF33190.1 - 1.1 9.2 12.6 0.28 11.2 6.5 2.3 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein PIF1 PF05970.14 CDF33192.1 - 1.1e-92 311.0 0.0 1.6e-92 310.5 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF33192.1 - 1.1e-59 201.9 0.0 2.6e-59 200.6 0.0 1.7 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF33192.1 - 3.5e-06 26.9 0.0 6.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF33192.1 - 0.056 13.1 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF33192.1 - 0.086 10.8 0.0 0.14 10.1 0.0 1.2 1 0 0 1 1 1 0 Helicase PIF1 PF05970.14 CDF33193.1 - 6.6e-96 321.6 0.0 8.7e-96 321.2 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF33193.1 - 2.2e-31 109.6 0.2 4.2e-31 108.6 0.2 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF33193.1 - 5.6e-07 29.5 0.0 1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_UL16 PF03044.14 CDF33193.1 - 0.094 12.0 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus UL16/UL94 family Amino_oxidase PF01593.24 CDF33194.1 - 3.4e-54 184.8 0.1 3.8e-54 184.7 0.1 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF33194.1 - 3.6e-14 52.8 0.3 7.1e-14 51.8 0.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF33194.1 - 9.2e-09 35.3 6.4 8.8e-06 25.5 1.1 2.8 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF33194.1 - 2.4e-06 27.0 0.5 2.9e-05 23.5 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 CDF33194.1 - 2.8e-05 23.1 0.0 0.0076 15.1 0.0 2.1 2 0 0 2 2 2 2 MCRA family FAD_oxidored PF12831.7 CDF33194.1 - 6.1e-05 22.5 0.3 0.00069 19.1 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDF33194.1 - 8.5e-05 21.4 1.0 0.0002 20.2 0.7 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 CDF33194.1 - 8.5e-05 22.0 0.2 0.00037 19.9 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 CDF33194.1 - 0.00024 20.3 2.4 0.00085 18.5 1.9 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CDF33194.1 - 0.00027 21.4 0.2 0.015 15.9 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF33194.1 - 0.00094 18.4 0.5 0.0015 17.7 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CDF33194.1 - 0.0035 16.7 0.0 0.0074 15.7 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDF33194.1 - 0.0092 15.9 0.6 0.016 15.1 0.6 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDF33194.1 - 0.012 15.2 0.2 0.029 13.9 0.1 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 CDF33194.1 - 0.013 14.6 0.1 0.02 14.0 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 CDF33194.1 - 0.016 14.9 0.2 0.028 14.1 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 CDF33194.1 - 0.034 13.4 2.2 0.07 12.4 0.2 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CDF33194.1 - 0.082 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDF33194.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding CDP-OH_P_transf PF01066.21 CDF33197.1 - 0.012 16.4 0.5 0.012 16.4 0.5 3.3 2 1 0 2 2 2 0 CDP-alcohol phosphatidyltransferase DUF5337 PF17272.2 CDF33197.1 - 4.2 7.3 6.8 0.45 10.4 1.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5337) UAA PF08449.11 CDF33198.1 - 7.2e-61 206.0 13.6 8.3e-61 205.8 13.6 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDF33198.1 - 1.1e-10 41.9 20.6 7e-08 32.7 8.4 2.4 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 CDF33198.1 - 4.7e-05 22.7 8.1 0.023 13.9 2.8 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 CDF33198.1 - 0.00079 18.9 7.3 0.011 15.1 0.4 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family CRT-like PF08627.10 CDF33198.1 - 0.0059 15.6 0.7 0.0059 15.6 0.7 1.6 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like TMEM234 PF10639.9 CDF33198.1 - 0.016 15.3 9.4 1.1 9.3 0.2 2.8 2 1 0 2 2 2 0 Putative transmembrane family 234 RT_RNaseH PF17917.1 CDF33201.1 - 1.3e-36 125.1 0.1 2.4e-36 124.2 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF33201.1 - 1e-33 115.3 0.1 1.9e-33 114.5 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF33201.1 - 2.7e-15 56.2 0.0 4.9e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF33201.1 - 1e-13 51.5 0.0 2.2e-12 47.2 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain NHase_beta PF02211.15 CDF33201.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Nitrile hydratase beta subunit rve_3 PF13683.6 CDF33201.1 - 0.027 14.2 0.0 0.067 13.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain DDE_3 PF13358.6 CDF33201.1 - 0.062 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.6 CDF33202.1 - 1.4e-19 70.3 0.0 1.8e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH PF17917.1 CDF33203.1 - 4.6e-32 110.4 0.0 2e-31 108.4 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF33203.1 - 1.1e-29 102.4 0.0 2.1e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF33203.1 - 5.2e-13 49.2 0.0 9e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF33203.1 - 1.4e-08 34.7 0.6 3.5e-08 33.4 0.6 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain NDUFB10 PF10249.9 CDF33206.1 - 0.0017 18.8 0.0 0.0021 18.6 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 Prenyltrans PF00432.21 CDF33208.1 - 1.2e-61 204.1 11.0 2.2e-15 56.1 0.5 5.1 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CDF33208.1 - 1.9e-06 27.2 0.0 0.039 13.0 0.0 2.8 1 1 2 3 3 3 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 CDF33208.1 - 1.9e-05 23.9 0.0 0.0004 19.6 0.0 2.1 1 1 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain RRM_1 PF00076.22 CDF33211.1 - 3.1e-16 58.9 0.0 9.2e-16 57.4 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 CDF33211.1 - 0.003 17.8 0.3 0.003 17.8 0.3 2.8 2 1 1 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 CDF33211.1 - 0.022 14.8 0.1 0.041 13.9 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 CDF33211.1 - 0.042 13.4 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF33211.1 - 0.16 11.9 0.2 0.68 9.8 0.0 2.2 3 0 0 3 3 3 0 Occluded RNA-recognition motif NOG1_N PF17835.1 CDF33212.1 - 1.6e-51 174.4 0.0 1.6e-51 174.4 0.0 2.8 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 CDF33212.1 - 8.6e-26 89.7 1.6 1.7e-25 88.7 1.6 1.5 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 CDF33212.1 - 1.1e-25 89.1 0.0 2.4e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 CDF33212.1 - 2.4e-17 63.1 0.0 6.1e-17 61.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF33212.1 - 3.1e-08 33.3 0.0 6.9e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CDF33212.1 - 0.00043 19.7 0.1 0.0014 18.0 0.0 1.9 2 0 0 2 2 2 1 AIG1 family PduV-EutP PF10662.9 CDF33212.1 - 0.0024 17.6 0.0 0.0089 15.8 0.0 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 CDF33212.1 - 0.0059 16.5 0.3 0.75 9.7 0.0 3.8 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 CDF33212.1 - 0.0078 16.6 0.1 0.16 12.3 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 CDF33212.1 - 0.024 14.7 0.7 2.7 8.0 0.0 3.1 2 1 1 3 3 3 0 Dynamin family SRPRB PF09439.10 CDF33212.1 - 0.065 12.7 0.0 0.22 10.9 0.0 1.8 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 CDF33212.1 - 0.14 12.2 0.1 0.51 10.4 0.0 2.1 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain DUF4055 PF13264.6 CDF33213.1 - 0.057 13.6 1.7 0.11 12.6 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) G_path_suppress PF15991.5 CDF33214.1 - 2.1e-05 24.8 4.3 2.7e-05 24.5 4.3 1.2 1 0 0 1 1 1 1 G-protein pathway suppressor PCRF PF03462.18 CDF33214.1 - 0.003 17.4 2.1 0.0039 17.1 2.1 1.1 1 0 0 1 1 1 1 PCRF domain Mit_ribos_Mrp51 PF11709.8 CDF33214.1 - 0.027 14.1 1.4 0.033 13.8 1.4 1.0 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit Phage_GPO PF05929.11 CDF33214.1 - 0.038 13.6 3.3 0.044 13.4 3.3 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Bcr-Abl_Oligo PF09036.10 CDF33214.1 - 0.066 13.2 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain DUF2278 PF10042.9 CDF33214.1 - 0.08 13.0 0.0 0.09 12.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) MIF4G_like_2 PF09090.11 CDF33214.1 - 0.082 12.4 2.2 0.09 12.2 2.2 1.1 1 0 0 1 1 1 0 MIF4G like ZapB PF06005.12 CDF33214.1 - 0.6 10.6 7.3 3 8.3 1.3 2.2 2 0 0 2 2 2 0 Cell division protein ZapB M PF02370.16 CDF33214.1 - 1.8 9.4 8.3 0.68 10.7 1.1 3.1 2 0 0 2 2 2 0 M protein repeat APG6_N PF17675.1 CDF33214.1 - 2.1 8.9 14.0 3.9 8.0 1.6 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region bZIP_1 PF00170.21 CDF33215.1 - 1.8e-07 31.2 8.9 4.9e-07 29.8 8.9 1.8 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CDF33215.1 - 3.5e-05 23.8 2.8 3.5e-05 23.8 2.8 2.4 2 0 0 2 2 2 1 Basic region leucine zipper tRNA-synt_1b PF00579.25 CDF33216.1 - 1.5e-77 260.9 0.0 2.2e-77 260.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 CDF33216.1 - 7.7e-05 22.3 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 S4 domain TyrRSs_C PF16714.5 CDF33216.1 - 0.009 15.8 0.5 0.11 12.3 0.5 2.4 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain CDC27 PF09507.10 CDF33217.1 - 0.00076 19.0 14.5 0.0014 18.2 14.5 1.4 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Red1 PF07964.11 CDF33217.1 - 0.16 10.2 4.3 0.15 10.2 4.3 1.1 1 0 0 1 1 1 0 Rec10 / Red1 HSP20 PF00011.21 CDF33220.1 - 5.4e-11 42.5 0.2 2.3e-09 37.3 0.2 2.1 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDF33220.1 - 0.0013 18.3 0.0 0.0033 16.9 0.0 1.7 2 0 0 2 2 2 1 HSP20-like domain found in ArsA AMH_N PF04709.12 CDF33224.1 - 0.2 10.5 0.3 0.27 10.1 0.3 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region DnaJ_C PF01556.18 CDF33228.1 - 9.8e-30 103.6 0.0 1.3e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDF33228.1 - 3.2e-20 72.0 0.2 5.2e-20 71.3 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDF33228.1 - 2.2e-10 40.7 18.6 4e-10 39.9 18.6 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CDF33228.1 - 0.01 15.8 20.7 0.018 15.0 6.5 3.2 1 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CDF33228.1 - 0.46 10.5 11.1 0.46 10.5 3.0 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 CDF33228.1 - 2 8.9 7.4 0.59 10.6 3.8 2.1 2 1 0 2 2 2 0 Restriction alleviation protein Lar Sin3_corepress PF08295.12 CDF33229.1 - 4.6e-30 103.6 0.0 1.8e-29 101.7 0.0 2.1 1 0 0 1 1 1 1 Sin3 family co-repressor PAH PF02671.21 CDF33229.1 - 5.1e-27 93.8 8.3 9.3e-17 60.9 0.1 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3a_C PF16879.5 CDF33229.1 - 2.4e-14 53.7 5.2 2.9e-13 50.2 0.0 3.5 2 1 0 3 3 3 1 C-terminal domain of Sin3a protein Ku_PK_bind PF08785.11 CDF33229.1 - 0.0069 16.5 0.9 1.8 8.7 0.0 3.4 3 0 0 3 3 3 2 Ku C terminal domain like tRNA-synt_1_2 PF13603.6 CDF33230.1 - 9.1e-55 185.0 0.0 1.4e-54 184.4 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1 PF00133.22 CDF33230.1 - 1.7e-52 178.6 6.5 6.5e-37 127.1 0.8 5.7 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDF33230.1 - 1.6e-24 86.4 0.0 1.7e-15 56.7 0.0 3.6 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CDF33230.1 - 1.7e-16 60.5 0.4 1.7e-15 57.3 0.4 2.2 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CDF33230.1 - 0.0011 18.4 0.0 0.2 11.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDF33230.1 - 0.015 14.3 0.0 0.042 12.7 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (K) TyrRSs_C PF16714.5 CDF33230.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Tyrosyl-tRNA synthetase C-terminal domain Sld5 PF05916.11 CDF33231.1 - 2.6e-07 31.1 0.0 3.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein DKCLD PF08068.12 CDF33232.1 - 9.8e-33 112.0 0.1 3.5e-32 110.3 0.2 2.0 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 CDF33232.1 - 2.5e-21 76.6 0.2 1.3e-18 67.7 0.2 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CDF33232.1 - 1.6e-20 73.0 0.1 2.8e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 CDF33232.1 - 2e-17 62.9 2.5 4.6e-17 61.7 2.5 1.7 1 0 0 1 1 1 1 PUA domain VIR_N PF15912.5 CDF33232.1 - 1.2 8.6 10.3 1.8 8.1 10.3 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Coilin_N PF15862.5 CDF33232.1 - 1.6 8.5 19.0 3.3 7.5 19.0 1.4 1 0 0 1 1 1 0 Coilin N-terminus Peptidase_S49_N PF08496.10 CDF33232.1 - 3.8 7.6 10.9 24 5.0 11.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal MCM_bind PF09739.9 CDF33233.1 - 2.5e-93 313.5 0.0 7.4e-93 312.0 0.0 1.6 1 1 0 1 1 1 1 Mini-chromosome maintenance replisome factor DUF1180 PF06679.12 CDF33233.1 - 0.38 11.2 4.5 0.64 10.4 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) MCM PF00493.23 CDF33234.1 - 2.5e-93 311.3 0.0 4.1e-93 310.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDF33234.1 - 8.5e-28 96.7 0.0 1.6e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDF33234.1 - 6.1e-19 68.2 3.2 1.3e-18 67.2 3.2 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDF33234.1 - 2.5e-09 37.7 0.3 1.2e-08 35.4 0.0 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CDF33234.1 - 9.3e-09 35.0 0.1 3.1e-07 30.0 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDF33234.1 - 0.0024 17.6 0.0 0.0075 16.0 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 CDF33234.1 - 0.0028 17.5 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDF33234.1 - 0.01 15.9 0.0 0.042 13.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Aminotran_5 PF00266.19 CDF33235.1 - 0.0097 14.9 0.0 0.016 14.1 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Myb_DNA-binding PF00249.31 CDF33237.1 - 3.6e-17 62.3 2.5 8.8e-10 38.6 0.3 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF33237.1 - 6.5e-10 39.1 7.8 1.7e-07 31.4 0.1 4.5 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF33237.1 - 0.00016 21.5 8.5 0.00033 20.5 0.5 3.5 3 0 0 3 3 3 1 Myb DNA-binding like Thymidylat_synt PF00303.19 CDF33238.1 - 2.8e-115 384.1 0.0 3.5e-115 383.7 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 CDF33238.1 - 4.3e-32 111.0 0.0 6e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase APG17 PF04108.12 CDF33240.1 - 0.0074 15.5 0.0 0.0079 15.3 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 DHR10 PF18595.1 CDF33240.1 - 0.011 15.7 0.9 0.015 15.4 0.9 1.1 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DUF1640 PF07798.11 CDF33240.1 - 0.053 13.6 0.2 0.069 13.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF1043 PF06295.12 CDF33240.1 - 0.12 12.4 0.2 0.16 11.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) GAS PF13851.6 CDF33240.1 - 0.13 11.6 0.2 0.16 11.3 0.2 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding EzrA PF06160.12 CDF33240.1 - 0.16 10.1 0.1 0.2 9.8 0.1 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Nup54_57_C PF18570.1 CDF33240.1 - 0.17 11.5 0.1 0.27 10.9 0.1 1.3 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain AA_kinase PF00696.28 CDF33241.1 - 5.2e-14 52.4 0.0 7.3e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family Acetyltransf_1 PF00583.25 CDF33241.1 - 1.4e-05 25.3 0.0 2.8e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF33241.1 - 7.4e-05 23.1 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDF33241.1 - 0.0079 16.1 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain HSP90 PF00183.18 CDF33242.1 - 1.5e-158 528.9 6.7 1.5e-158 528.9 6.7 2.3 2 1 0 2 2 2 1 Hsp90 protein HATPase_c PF02518.26 CDF33242.1 - 1e-11 45.3 0.1 2.3e-11 44.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDF33242.1 - 1.6e-11 44.2 0.8 3.7e-11 43.0 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF948 PF06103.11 CDF33242.1 - 7.4 6.9 6.0 9.3 6.6 0.3 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Bromodomain PF00439.25 CDF33243.1 - 4.3e-07 29.9 0.0 9.2e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Bromodomain NDUFA12 PF05071.16 CDF33244.1 - 5.6e-08 33.5 0.6 1.1e-07 32.6 0.6 1.5 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Cutinase PF01083.22 CDF33244.1 - 0.073 13.0 0.1 0.092 12.7 0.1 1.2 1 0 0 1 1 1 0 Cutinase Peptidase_M64 PF09471.10 CDF33244.1 - 0.098 12.2 0.1 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 IgA Peptidase M64 His_Phos_2 PF00328.22 CDF33246.1 - 1e-22 81.0 0.0 2.3e-19 70.0 0.0 2.5 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) DUF2892 PF11127.8 CDF33246.1 - 0.078 13.0 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) Tetraspanin PF00335.20 CDF33246.1 - 0.22 11.2 0.1 0.34 10.6 0.1 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF1415 PF07209.12 CDF33247.1 - 9.8e-33 113.3 0.0 1.9e-32 112.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1415) Condensin2nSMC PF12422.8 CDF33247.1 - 1.1e-32 113.3 0.0 3.7e-32 111.6 0.0 2.0 1 0 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit HEAT_2 PF13646.6 CDF33247.1 - 0.0014 19.0 0.5 0.14 12.5 0.0 3.8 2 1 1 3 3 3 1 HEAT repeats DUF2423 PF10338.9 CDF33247.1 - 0.019 15.2 0.5 0.057 13.6 0.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) HEAT PF02985.22 CDF33247.1 - 1.3 9.5 12.0 11 6.6 0.0 5.5 6 0 0 6 6 6 0 HEAT repeat Macro_2 PF14519.6 CDF33248.1 - 0.037 13.4 0.6 6.7 6.0 0.0 2.4 2 1 0 2 2 2 0 Macro-like domain DUF4064 PF13273.6 CDF33248.1 - 0.055 13.8 0.2 0.055 13.8 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) MMR_HSR1 PF01926.23 CDF33249.1 - 1.9e-10 40.8 0.0 3.1e-08 33.7 0.0 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF33249.1 - 8.5e-05 22.5 0.4 0.053 13.4 0.4 2.6 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 CDF33249.1 - 0.00097 18.7 0.1 2.3 7.7 0.0 2.8 3 0 0 3 3 3 2 Ferrous iron transport protein B cobW PF02492.19 CDF33249.1 - 0.0035 17.0 0.0 0.011 15.3 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CDF33249.1 - 0.096 11.6 0.2 1.1 8.2 0.0 2.4 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AhpC-TSA PF00578.21 CDF33250.1 - 2.7e-29 101.6 0.0 3.3e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF33250.1 - 5.7e-17 61.8 0.0 6.7e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 CDF33250.1 - 0.084 13.2 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Glyco_hydro_16 PF00722.21 CDF33251.1 - 5.7e-13 48.7 1.6 8.9e-13 48.1 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TPR_14 PF13428.6 CDF33252.1 - 1.5e-09 37.9 27.0 0.0087 16.8 0.6 10.2 10 2 2 12 12 12 4 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF33252.1 - 0.00025 21.0 9.8 15 5.6 0.3 7.4 7 3 0 7 7 7 2 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 CDF33252.1 - 0.0008 19.4 0.1 7.7 7.0 0.1 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF33252.1 - 0.0045 17.0 2.5 8.2 6.8 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33252.1 - 0.5 11.1 21.9 4.2 8.1 0.2 6.6 6 1 1 7 7 7 0 Tetratricopeptide repeat HAT PF02184.16 CDF33252.1 - 0.61 10.1 0.0 0.61 10.1 0.0 5.7 6 0 0 6 6 6 0 HAT (Half-A-TPR) repeat Glyco_transf_64 PF09258.10 CDF33253.1 - 6.3e-42 143.5 0.0 8.8e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Glyco_transf_8 PF01501.20 CDF33253.1 - 7.8e-10 38.7 5.2 6.6e-05 22.6 0.0 2.2 1 1 0 2 2 2 2 Glycosyl transferase family 8 Nsp1_C PF05064.13 CDF33256.1 - 0.0048 16.7 0.2 0.0048 16.7 0.2 2.3 2 0 0 2 2 2 1 Nsp1-like C-terminal region bZIP_1 PF00170.21 CDF33256.1 - 0.011 15.8 9.8 0.011 15.8 9.8 2.3 2 0 0 2 2 2 0 bZIP transcription factor WDCP PF15390.6 CDF33256.1 - 0.043 12.2 1.5 0.069 11.5 1.5 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family TFIIA PF03153.13 CDF33256.1 - 0.61 10.0 20.6 0.9 9.5 20.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_S49 PF01343.18 CDF33259.1 - 5.7e-51 172.5 0.0 4.5e-33 114.4 0.3 2.1 2 0 0 2 2 2 2 Peptidase family S49 Trimer_CC PF08954.11 CDF33261.1 - 0.011 15.3 1.4 0.024 14.2 1.4 1.7 1 1 0 1 1 1 0 Trimerisation motif DUF4407 PF14362.6 CDF33261.1 - 0.03 13.7 0.1 0.036 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WDCP PF15390.6 CDF33261.1 - 0.17 10.2 2.1 0.19 10.0 2.1 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family FAM220 PF15487.6 CDF33261.1 - 0.38 10.4 9.4 0.44 10.1 9.4 1.0 1 0 0 1 1 1 0 FAM220 family TAF1D PF15333.6 CDF33261.1 - 0.39 10.4 10.0 0.47 10.2 10.0 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Macoilin PF09726.9 CDF33261.1 - 0.46 9.0 6.8 0.55 8.7 6.8 1.1 1 0 0 1 1 1 0 Macoilin family ATG16 PF08614.11 CDF33261.1 - 0.71 10.1 5.4 0.91 9.7 5.4 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Presenilin PF01080.17 CDF33261.1 - 6.3 5.5 7.2 7.6 5.2 7.2 1.0 1 0 0 1 1 1 0 Presenilin Fringe PF02434.16 CDF33265.1 - 2.9e-09 36.8 0.0 1.8e-08 34.1 0.0 1.9 1 1 0 1 1 1 1 Fringe-like DUF604 PF04646.12 CDF33265.1 - 1e-05 25.1 0.3 1.7e-05 24.3 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Galactosyl_T PF01762.21 CDF33265.1 - 0.0083 16.0 0.0 0.017 15.0 0.0 1.5 1 1 0 1 1 1 1 Galactosyltransferase JCAD PF15351.6 CDF33265.1 - 0.22 9.3 0.0 0.29 8.9 0.0 1.1 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease Pkinase PF00069.25 CDF33267.1 - 3.4e-16 59.4 0.0 4.8e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33267.1 - 3.7e-09 36.3 0.0 5.2e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF33267.1 - 1.8e-05 24.2 0.1 2.8e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDF33267.1 - 4.5e-05 23.1 0.1 7.4e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 CDF33267.1 - 5.7e-05 23.1 0.1 8.9e-05 22.5 0.1 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF33267.1 - 0.00065 18.6 0.1 0.0013 17.6 0.1 1.3 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF33267.1 - 0.044 13.1 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 Kinase-like EcKinase PF02958.20 CDF33267.1 - 0.13 11.6 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Beta-Casp PF10996.8 CDF33269.1 - 1.2e-29 102.8 0.0 2.3e-29 101.9 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain CPSF73-100_C PF11718.8 CDF33269.1 - 2.2e-25 89.5 0.3 7.1e-23 81.3 0.3 2.4 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_6 PF16661.5 CDF33269.1 - 7.7e-18 64.6 0.0 1.6e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF33269.1 - 4.4e-17 62.7 0.1 6.3e-16 59.0 0.1 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 CDF33269.1 - 9.8e-14 51.0 0.0 1.9e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 CDF33269.1 - 1.2e-09 38.0 0.0 2.8e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDF33269.1 - 1.3e-06 28.4 0.0 6.7e-06 26.1 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DNA_gyraseB PF00204.25 CDF33270.1 - 5.2e-56 188.9 0.0 9.7e-56 188.0 0.0 1.5 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 CDF33270.1 - 2.8e-28 97.9 0.1 7.4e-28 96.5 0.1 1.8 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDF33270.1 - 7.9e-22 77.9 0.2 1.8e-21 76.8 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDF33270.1 - 1.5e-17 63.7 0.0 3e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Toprim domain HATPase_c_3 PF13589.6 CDF33270.1 - 9.2e-05 22.3 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TOPRIM_C PF16898.5 CDF33270.1 - 0.0048 17.2 0.0 0.0088 16.3 0.0 1.3 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM Pribosyltran_N PF13793.6 CDF33271.1 - 6.4e-43 145.4 0.0 2e-42 143.8 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDF33271.1 - 2.8e-23 82.9 0.2 9.2e-23 81.2 0.0 1.8 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDF33271.1 - 9e-17 61.0 0.7 2.1e-16 59.9 0.7 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDF33271.1 - 0.0031 17.0 0.1 0.0056 16.1 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Glutaredoxin PF00462.24 CDF33272.1 - 7.1e-19 67.8 0.2 3.9e-18 65.4 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin 6PF2K PF01591.18 CDF33272.1 - 0.2 10.9 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Coatomer_WDAD PF04053.14 CDF33274.1 - 2.9e-152 507.8 0.0 6.7e-151 503.3 0.0 2.2 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 CDF33274.1 - 2.6e-40 135.7 7.1 9.4e-08 32.6 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33274.1 - 8.3e-08 32.4 0.1 0.21 11.9 0.0 5.6 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF33274.1 - 0.001 18.4 0.1 0.034 13.5 0.0 2.4 2 0 0 2 2 2 1 WD40-like domain BBS2_Mid PF14783.6 CDF33274.1 - 0.0064 16.5 0.0 3.4 7.8 0.0 3.2 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region PQQ PF01011.21 CDF33274.1 - 0.0085 16.0 0.8 0.11 12.4 0.0 3.3 4 0 0 4 4 4 1 PQQ enzyme repeat Nup160 PF11715.8 CDF33274.1 - 0.031 12.9 0.0 4.6 5.8 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Vps39_1 PF10366.9 CDF33274.1 - 0.049 13.9 0.2 0.33 11.3 0.1 2.2 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 HAD PF12710.7 CDF33275.1 - 0.013 16.0 0.1 0.025 15.0 0.1 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase AF0941-like PF14591.6 CDF33276.1 - 0.12 13.0 0.1 0.3 11.6 0.0 1.7 2 0 0 2 2 2 0 AF0941-like zf-C2H2 PF00096.26 CDF33277.1 - 2.1e-06 27.9 7.1 0.0075 16.7 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF33277.1 - 0.00022 21.5 0.5 0.00022 21.5 0.5 3.1 3 0 0 3 3 3 1 Zinc-finger double domain IBR PF01485.21 CDF33277.1 - 0.00043 20.4 0.7 0.00075 19.7 0.7 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zf-C2H2_4 PF13894.6 CDF33277.1 - 0.0014 19.2 5.7 0.18 12.8 1.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger SRP-alpha_N PF04086.13 CDF33277.1 - 0.085 12.8 7.2 0.12 12.3 7.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal FYDLN_acid PF09538.10 CDF33277.1 - 0.2 12.3 5.3 2.4 8.9 5.3 2.3 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Macoilin PF09726.9 CDF33277.1 - 0.48 8.9 7.4 0.61 8.6 7.4 1.1 1 0 0 1 1 1 0 Macoilin family Zn_Tnp_IS1595 PF12760.7 CDF33277.1 - 0.68 10.0 4.7 20 5.2 0.7 2.4 1 1 1 2 2 2 0 Transposase zinc-ribbon domain ATG16 PF08614.11 CDF33277.1 - 8.5 6.5 7.3 17 5.6 7.3 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Thymidylate_kin PF02223.17 CDF33279.1 - 8.8e-35 120.1 0.0 1e-34 119.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 CDF33279.1 - 0.0023 18.2 0.1 0.0038 17.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain PROCN PF08083.11 CDF33279.1 - 0.19 10.4 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 PROCN (NUC071) domain Voltage_CLC PF00654.20 CDF33282.1 - 2.7e-61 207.8 35.5 4.2e-61 207.1 35.5 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 CDF33282.1 - 0.0015 19.0 0.0 0.1 13.0 0.0 2.6 2 0 0 2 2 2 1 CBS domain Caveolin PF01146.17 CDF33282.1 - 2.5 8.1 5.1 21 5.1 0.3 3.0 3 0 0 3 3 3 0 Caveolin DEAD PF00270.29 CDF33283.1 - 1.1e-37 129.5 0.8 3.2e-37 128.0 0.4 2.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF33283.1 - 4.2e-29 101.1 0.0 2.3e-27 95.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF33283.1 - 2e-07 31.2 0.0 4e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CDF33283.1 - 0.0067 16.8 0.2 0.013 15.8 0.2 1.4 1 0 0 1 1 1 1 AAA domain Spore_coat_CotO PF14153.6 CDF33283.1 - 3.3 7.6 10.8 8.4 6.3 10.8 1.7 1 0 0 1 1 1 0 Spore coat protein CotO Creatininase PF02633.14 CDF33284.1 - 4.9e-59 199.7 0.1 6e-59 199.4 0.1 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase ABC_tran PF00005.27 CDF33286.1 - 3.9e-23 82.5 0.0 6.4e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF33286.1 - 4.7e-08 33.2 0.0 0.00014 21.8 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF33286.1 - 2.8e-06 27.0 0.0 0.053 12.9 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 CDF33286.1 - 9e-05 22.2 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF33286.1 - 0.00021 21.0 0.0 0.00041 20.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF33286.1 - 0.0007 20.0 0.0 0.00098 19.5 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CDF33286.1 - 0.0021 18.0 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_23 PF13476.6 CDF33286.1 - 0.0059 17.1 0.0 0.0084 16.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDF33286.1 - 0.0079 16.4 0.0 0.018 15.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 CDF33286.1 - 0.013 15.8 0.3 0.22 11.8 0.3 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA PF00004.29 CDF33286.1 - 0.014 15.8 0.1 0.076 13.4 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDF33286.1 - 0.018 14.6 0.1 0.05 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CDF33286.1 - 0.027 14.2 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 CDF33286.1 - 0.029 13.2 0.1 1.1 8.0 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 CDF33286.1 - 0.032 13.9 0.0 0.086 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDF33286.1 - 0.037 14.3 0.1 0.1 12.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDF33286.1 - 0.045 13.6 0.0 0.069 13.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 CDF33286.1 - 0.053 13.4 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 CDF33286.1 - 0.057 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDF33286.1 - 0.12 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MIF4G PF02854.19 CDF33288.1 - 3.5e-09 36.6 0.0 6.4e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 CDF33288.1 - 7.3e-06 25.9 0.0 3.7e-05 23.7 0.0 2.2 3 0 0 3 3 3 1 MA3 domain DUF445 PF04286.12 CDF33288.1 - 0.014 15.2 0.1 0.27 11.0 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF445) Cgr1 PF03879.14 CDF33289.1 - 1e-07 32.3 22.2 1.2e-07 32.0 22.2 1.0 1 0 0 1 1 1 1 Cgr1 family UBA2_C PF16195.5 CDF33289.1 - 0.67 10.7 11.8 0.98 10.1 9.7 2.1 1 1 1 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Golgin_A5 PF09787.9 CDF33290.1 - 7.2e-14 52.0 37.7 1.3e-12 47.8 11.2 3.7 2 2 0 2 2 2 2 Golgin subfamily A member 5 CLZ PF16526.5 CDF33290.1 - 0.0028 18.0 0.7 0.0028 18.0 0.7 4.3 6 0 0 6 6 5 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ATG16 PF08614.11 CDF33290.1 - 0.022 15.0 12.7 0.022 15.0 12.7 3.8 1 1 0 2 2 1 0 Autophagy protein 16 (ATG16) YabA PF06156.13 CDF33290.1 - 0.031 14.9 1.3 0.031 14.9 1.3 3.9 2 2 2 4 4 4 0 Initiation control protein YabA DUF751 PF05421.11 CDF33290.1 - 0.23 12.2 0.1 0.38 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF751) HALZ PF02183.18 CDF33290.1 - 0.62 10.3 14.2 0.29 11.4 3.8 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper Fez1 PF06818.15 CDF33290.1 - 1 9.8 43.2 1.2 9.5 10.8 2.8 1 1 1 2 2 2 0 Fez1 FlaC_arch PF05377.11 CDF33290.1 - 1.4 9.3 15.8 2.5 8.5 0.6 4.4 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 CDF33290.1 - 1.9 8.5 37.4 0.21 11.6 4.0 4.3 3 1 0 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin-6_N PF09177.11 CDF33290.1 - 3.6 8.2 14.9 1.5 9.4 0.7 3.4 2 2 0 3 3 3 0 Syntaxin 6, N-terminal FAM76 PF16046.5 CDF33290.1 - 6.2 6.1 30.5 0.16 11.3 4.5 2.6 2 1 0 2 2 2 0 FAM76 protein Fib_alpha PF08702.10 CDF33290.1 - 6.5 6.9 9.4 14 5.9 0.2 3.2 2 2 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF4718 PF15842.5 CDF33291.1 - 0.24 11.2 2.6 0.3 10.9 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) LdpA_C PF12617.8 CDF33293.1 - 2e-45 154.7 0.1 2.9e-45 154.2 0.1 1.1 1 0 0 1 1 1 1 Iron-Sulfur binding protein C terminal Fer4_7 PF12838.7 CDF33293.1 - 1.1e-06 29.1 5.7 0.00033 21.2 0.2 2.8 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDF33293.1 - 5e-06 26.3 16.4 0.006 16.6 4.4 2.8 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 CDF33293.1 - 0.00015 22.6 7.5 0.0084 17.0 0.2 2.6 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4 PF00037.27 CDF33293.1 - 0.00025 20.7 5.6 0.00025 20.7 5.6 2.9 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDF33293.1 - 0.00055 20.1 9.9 0.02 15.1 11.3 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDF33293.1 - 0.0042 17.5 1.0 0.059 13.8 0.0 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDF33293.1 - 0.015 15.4 1.0 0.015 15.4 1.0 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDF33293.1 - 0.049 13.7 17.4 0.18 12.0 4.4 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.7 CDF33293.1 - 0.084 13.4 1.2 0.084 13.4 1.2 2.9 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 CDF33293.1 - 0.17 12.9 19.5 0.088 13.8 5.7 3.3 2 1 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 CDF33293.1 - 2 9.3 5.8 0.77 10.6 2.6 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDF33293.1 - 5.3 7.7 11.6 0.15 12.6 1.8 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 CDF33293.1 - 6.6 7.5 9.5 1.2 9.9 0.2 3.5 4 0 0 4 4 4 0 4Fe-4S single cluster domain HAD_SAK_1 PF10307.9 CDF33294.1 - 1.3e-09 38.2 0.0 2.2e-09 37.4 0.0 1.4 1 1 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins HAD PF12710.7 CDF33294.1 - 0.063 13.7 0.0 2.5 8.5 0.0 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase BCCT PF02028.17 CDF33295.1 - 0.01 14.3 0.4 0.015 13.8 0.4 1.2 1 0 0 1 1 1 0 BCCT, betaine/carnitine/choline family transporter Wzy_C PF04932.15 CDF33295.1 - 0.42 10.2 0.0 0.42 10.2 0.0 2.1 2 0 0 2 2 2 0 O-Antigen ligase HSP90 PF00183.18 CDF33296.1 - 3e-39 135.3 0.1 4.3e-39 134.8 0.0 1.3 1 1 0 1 1 1 1 Hsp90 protein DNA_pol_phi PF04931.13 CDF33296.1 - 3.8 5.5 9.1 1.2e+02 0.6 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase phi Ctr PF04145.15 CDF33298.1 - 3.3e-13 50.5 11.0 1e-09 39.1 3.8 2.1 1 1 1 2 2 2 2 Ctr copper transporter family Hpre_diP_synt_I PF07456.11 CDF33298.1 - 5.9e-05 23.1 4.5 7e-05 22.9 4.5 1.1 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase component I PHO4 PF01384.20 CDF33298.1 - 0.054 12.5 5.4 0.063 12.3 5.4 1.1 1 0 0 1 1 1 0 Phosphate transporter family UPF0121 PF03661.13 CDF33298.1 - 0.091 12.1 2.5 0.1 12.0 2.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0121) FtsX PF02687.21 CDF33298.1 - 0.1 13.1 3.8 0.22 12.0 0.5 2.1 2 0 0 2 2 2 0 FtsX-like permease family PhoR PF11808.8 CDF33298.1 - 0.12 12.7 5.8 1.4 9.4 1.2 2.2 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF5337 PF17272.2 CDF33298.1 - 0.13 12.1 8.0 0.19 11.6 3.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5337) LapA_dom PF06305.11 CDF33298.1 - 0.2 11.5 4.6 0.75 9.7 1.2 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF4133 PF13571.6 CDF33298.1 - 1.4 9.3 7.2 0.55 10.6 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4133) VirB3 PF05101.13 CDF33298.1 - 2.6 8.4 9.2 1.6 9.0 5.6 2.0 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein zf-U1 PF06220.12 CDF33300.1 - 1.2e-14 53.8 7.7 1.8e-14 53.2 7.7 1.3 1 0 0 1 1 1 1 U1 zinc finger tRNA-synt_2b PF00587.25 CDF33301.1 - 2.9e-32 112.1 0.0 4.3e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CDF33301.1 - 2.2e-19 69.6 2.1 4.5e-19 68.7 2.1 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ADH_zinc_N_2 PF13602.6 CDF33305.1 - 5e-18 66.4 2.2 2.7e-17 64.1 2.2 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDF33305.1 - 7.2e-10 38.7 0.1 2.9e-09 36.8 0.0 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CDF33305.1 - 5.4e-09 36.1 3.0 8.9e-09 35.4 1.7 2.0 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CDF33305.1 - 0.018 14.9 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CDF33306.1 - 8e-19 69.0 2.7 4.7e-18 66.5 2.7 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CDF33306.1 - 2.9e-10 40.2 1.1 2.9e-10 40.2 1.1 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDF33306.1 - 4.6e-10 39.4 0.0 1.1e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CDF33306.1 - 0.011 15.6 0.0 0.033 14.1 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase RHD3 PF05879.12 CDF33307.1 - 3.1e-62 210.8 0.1 3.9e-62 210.5 0.1 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 CDF33307.1 - 4.2e-07 30.2 1.5 7.1e-07 29.4 0.1 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CDF33307.1 - 3.2e-05 24.0 0.0 8.6e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CDF33307.1 - 0.00041 20.9 2.3 0.018 15.6 0.0 3.1 3 0 0 3 3 3 1 ABC transporter RsgA_GTPase PF03193.16 CDF33307.1 - 0.026 14.4 0.1 0.026 14.4 0.1 1.8 2 0 0 2 2 2 0 RsgA GTPase GBP PF02263.19 CDF33307.1 - 0.033 13.5 0.1 0.1 11.8 0.0 1.8 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain AAA_16 PF13191.6 CDF33307.1 - 0.037 14.4 0.2 0.12 12.7 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 CDF33307.1 - 0.039 14.2 0.8 0.067 13.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDF33307.1 - 0.061 13.8 0.8 5.9 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 CDF33307.1 - 0.081 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Roc PF08477.13 CDF33307.1 - 0.11 12.7 0.3 0.84 9.9 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Viral_helicase1 PF01443.18 CDF33307.1 - 0.15 11.7 0.3 0.48 10.1 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase GidB PF02527.15 CDF33311.1 - 1.3e-38 132.1 0.0 1.8e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MTS PF05175.14 CDF33311.1 - 0.0097 15.5 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDF33311.1 - 0.05 13.4 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Fer4 PF00037.27 CDF33314.1 - 1.2 9.1 15.9 1.1 9.2 2.9 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain rve PF00665.26 CDF33317.1 - 8e-08 32.5 0.0 3.2e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CDF33317.1 - 0.0043 16.7 0.0 0.57 9.8 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 CDF33320.1 - 4.6e-55 182.3 36.9 1.3e-08 35.4 1.0 8.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33320.1 - 6.3e-17 61.7 7.5 0.16 12.3 0.1 6.9 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF33320.1 - 1.8e-13 50.3 0.0 3.5e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Nup160 PF11715.8 CDF33320.1 - 3.5e-08 32.6 6.0 0.45 9.1 0.1 5.9 1 1 5 6 6 6 4 Nucleoporin Nup120/160 Me-amine-dh_H PF06433.11 CDF33320.1 - 3.5e-07 29.4 0.7 0.29 10.0 0.0 3.5 1 1 2 3 3 3 3 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 CDF33320.1 - 5.3e-05 22.9 24.0 0.033 13.8 7.3 2.9 1 1 0 2 2 2 2 PQQ-like domain Ge1_WD40 PF16529.5 CDF33320.1 - 0.0006 18.9 5.4 27 3.6 0.0 5.9 1 1 5 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF33320.1 - 0.0044 16.4 0.2 15 4.8 0.0 5.0 3 2 4 7 7 7 1 WD40-like domain Peptidase_S9_N PF02897.15 CDF33320.1 - 0.03 13.1 9.4 2.3 6.9 0.1 5.0 1 1 4 5 5 5 0 Prolyl oligopeptidase, N-terminal beta-propeller domain PQQ PF01011.21 CDF33320.1 - 0.036 14.0 12.7 44 4.2 0.1 6.3 6 0 0 6 6 6 0 PQQ enzyme repeat NACHT PF05729.12 CDF33320.1 - 0.088 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain PQQ_3 PF13570.6 CDF33320.1 - 0.36 11.4 12.5 51 4.5 0.1 6.2 6 0 0 6 6 6 0 PQQ-like domain Ribosomal_L35Ae PF01247.18 CDF33325.1 - 5e-13 49.0 0.2 5.4e-13 48.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CDF33325.1 - 0.03 14.5 0.0 0.03 14.5 0.0 1.1 1 0 0 1 1 1 0 RimM N-terminal domain Ribosomal_L35Ae PF01247.18 CDF33326.1 - 0.00051 20.2 0.0 0.00059 19.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae WD40 PF00400.32 CDF33327.1 - 9.5e-38 127.5 28.4 4.9e-06 27.2 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat NB-ARC PF00931.22 CDF33327.1 - 1.3e-09 37.6 0.0 3.2e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF33327.1 - 3.5e-07 30.4 8.0 0.36 11.1 0.2 5.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF33327.1 - 0.00011 21.0 10.7 3.8 6.0 0.0 6.6 5 1 1 7 7 7 3 Nucleoporin Nup120/160 APAF1_C PF17908.1 CDF33327.1 - 0.036 14.1 0.0 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain APH PF01636.23 CDF33331.1 - 1.7e-08 34.7 0.1 3.4e-08 33.7 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF33331.1 - 0.00074 18.9 0.0 0.0016 17.8 0.0 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 CDF33331.1 - 0.0033 17.1 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 CDF33331.1 - 0.038 12.9 0.0 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DDE_3 PF13358.6 CDF33332.1 - 5.4e-17 61.9 0.0 8.7e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.32 CDF33333.1 - 0.00048 20.9 0.5 0.0011 19.7 0.5 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat NB-ARC PF00931.22 CDF33334.1 - 1.5e-13 50.5 0.0 2.6e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain HTH_Tnp_Tc3_1 PF11427.8 CDF33337.1 - 2e-06 27.5 0.0 3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF33337.1 - 2.2e-06 27.3 0.4 1.5e-05 24.7 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF33337.1 - 0.06 14.0 1.6 0.56 10.9 0.5 2.1 1 1 0 2 2 2 0 Homeodomain-like domain HTH_29 PF13551.6 CDF33337.1 - 0.078 13.0 0.2 0.26 11.4 0.2 1.9 1 1 0 1 1 1 0 Winged helix-turn helix HTH_7 PF02796.15 CDF33337.1 - 0.16 12.0 1.7 1.9 8.6 0.2 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase WD40 PF00400.32 CDF33339.1 - 9.8e-66 216.1 42.1 6.8e-09 36.2 0.1 9.6 9 0 0 9 9 9 8 WD domain, G-beta repeat NB-ARC PF00931.22 CDF33339.1 - 1.9e-15 56.7 0.0 3.7e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF33339.1 - 3.8e-15 56.0 16.5 0.0074 16.6 0.1 8.2 1 1 7 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF33339.1 - 1.7e-06 27.2 0.6 6.9 5.5 0.0 6.4 1 1 7 8 8 8 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDF33339.1 - 5.9e-05 21.9 11.6 6.3 5.3 0.0 7.6 6 1 1 8 8 8 2 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF33339.1 - 0.0011 19.2 0.0 0.0035 17.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Frtz PF11768.8 CDF33339.1 - 0.071 11.4 0.0 13 3.9 0.0 3.8 2 2 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz NACHT PF05729.12 CDF33339.1 - 0.074 13.0 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Cytochrom_D1 PF02239.16 CDF33339.1 - 0.21 10.1 25.5 0.13 10.8 3.3 4.2 1 1 4 5 5 5 0 Cytochrome D1 heme domain PQQ_3 PF13570.6 CDF33339.1 - 1 9.9 25.8 7 7.3 0.3 7.9 6 3 3 9 9 9 0 PQQ-like domain DUF3546 PF12066.8 CDF33341.1 - 1.1e-21 77.0 1.7 1.1e-21 77.0 1.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 CDF33341.1 - 1.3e-12 48.5 5.9 1.3e-12 48.5 5.9 2.4 1 1 1 2 2 2 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 CDF33341.1 - 0.00033 20.4 0.0 0.00079 19.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) GTP_cyclohydroI PF01227.22 CDF33342.1 - 2.1e-68 229.2 0.1 2.6e-68 228.9 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I Methyltr_RsmB-F PF01189.17 CDF33342.1 - 0.065 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F QueF PF14489.6 CDF33342.1 - 0.14 12.3 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 QueF-like protein B12-binding PF02310.19 CDF33343.1 - 7.2e-07 29.3 0.0 0.00068 19.7 0.0 2.3 2 0 0 2 2 2 2 B12 binding domain Radical_SAM PF04055.21 CDF33343.1 - 9.6e-06 26.1 0.0 2.9e-05 24.5 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily DUF4379 PF14311.6 CDF33344.1 - 0.00058 20.2 2.3 0.00058 20.2 2.3 3.1 3 0 0 3 3 3 2 Probable Zinc-ribbon domain Closter_coat PF01785.17 CDF33344.1 - 0.16 11.2 0.2 0.24 10.7 0.2 1.2 1 0 0 1 1 1 0 Closterovirus coat protein DUF953 PF06110.11 CDF33344.1 - 0.35 10.5 0.1 0.35 10.5 0.1 2.2 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF953) RT_RNaseH PF17917.1 CDF33346.1 - 3.1e-33 114.2 0.0 7.6e-33 112.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF33346.1 - 5.7e-26 90.5 0.0 1.2e-25 89.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF33346.1 - 4.9e-11 42.6 0.2 9.3e-11 41.7 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF33346.1 - 6.3e-10 39.3 0.1 1.5e-09 38.1 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CDF33346.1 - 0.00068 19.4 0.1 0.0026 17.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DUF2677 PF10838.8 CDF33347.1 - 0.035 14.1 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) Zw10 PF06248.13 CDF33348.1 - 1.2e-06 27.4 2.2 1.1e-05 24.3 0.0 2.9 3 0 0 3 3 3 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 CDF33348.1 - 0.00036 20.3 0.0 0.00071 19.4 0.0 1.5 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal DUF4709 PF15821.5 CDF33348.1 - 0.085 13.1 0.2 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4709) His_Phos_1 PF00300.22 CDF33349.1 - 9e-24 84.2 0.0 1.2e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 CDF33349.1 - 0.17 11.2 0.1 2 7.7 0.0 2.5 3 1 0 3 3 3 0 Histidine phosphatase superfamily (branch 2) MCM PF00493.23 CDF33350.1 - 2.6e-101 337.4 0.0 4.4e-101 336.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDF33350.1 - 4.7e-29 100.8 0.6 8e-29 100.0 0.6 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDF33350.1 - 4.7e-17 62.2 0.3 1.1e-16 61.0 0.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDF33350.1 - 5.9e-11 42.9 0.1 2.2e-10 41.0 0.1 2.0 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 CDF33350.1 - 1.3e-06 28.5 0.0 3.6e-06 27.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDF33350.1 - 1.4e-06 27.9 0.2 0.00015 21.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDF33350.1 - 0.00014 21.7 0.0 0.00033 20.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 CDF33350.1 - 0.0039 17.0 1.0 0.012 15.5 1.0 1.8 1 0 0 1 1 1 1 AAA lid domain Mg_chelatase_C PF13335.6 CDF33350.1 - 0.05 14.3 0.2 0.66 10.7 0.1 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal AAA_16 PF13191.6 CDF33350.1 - 0.1 13.0 0.2 0.35 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 CDF33350.1 - 0.14 12.6 0.1 0.54 10.7 0.1 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 CDF33351.1 - 3.3e-100 333.8 0.0 4.7e-100 333.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDF33351.1 - 1.2e-36 125.3 0.3 2.2e-36 124.5 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDF33351.1 - 1.9e-27 95.5 0.1 5.9e-27 93.9 0.1 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDF33351.1 - 6.6e-16 58.8 0.2 9.7e-15 55.0 0.0 2.7 2 0 0 2 2 2 1 MCM N-terminal domain MCM2_N PF12619.8 CDF33351.1 - 3.2e-14 53.5 23.6 3.2e-14 53.5 23.6 3.4 4 1 0 4 4 4 1 Mini-chromosome maintenance protein 2 Mg_chelatase PF01078.21 CDF33351.1 - 4.1e-08 32.9 0.0 6e-06 25.8 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDF33351.1 - 0.00021 21.3 0.0 0.00062 19.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDF33351.1 - 0.0032 17.3 0.0 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) PK PF00224.21 CDF33352.1 - 1.7e-71 241.0 0.1 6.1e-71 239.1 0.1 1.9 1 1 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDF33352.1 - 2.4e-21 76.2 0.1 1.3e-20 73.8 0.0 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CDF33352.1 - 2.9e-06 26.6 0.0 7.2e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family GGDEF_2 PF17853.1 CDF33352.1 - 0.1 12.9 0.5 0.65 10.3 0.2 2.5 2 1 0 2 2 2 0 GGDEF-like domain PGI PF00342.19 CDF33354.1 - 3.5e-208 692.1 0.0 4e-208 691.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase ELO PF01151.18 CDF33357.1 - 3e-48 164.5 16.4 3.3e-48 164.4 16.4 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CDC45 PF02724.14 CDF33359.1 - 2 6.6 11.0 2.9 6.1 11.0 1.1 1 0 0 1 1 1 0 CDC45-like protein ABC_membrane PF00664.23 CDF33364.1 - 7.5e-98 327.5 5.2 1.3e-54 185.7 0.2 3.1 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDF33364.1 - 1.3e-69 233.0 0.0 1.3e-33 116.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDF33364.1 - 5.6e-14 52.1 0.0 3.6e-07 29.8 0.0 3.6 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CDF33364.1 - 3.3e-07 29.5 1.0 0.018 13.8 0.1 3.7 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 CDF33364.1 - 1.6e-06 28.6 0.4 0.018 15.4 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDF33364.1 - 2.9e-06 27.3 0.1 0.063 13.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 CDF33364.1 - 4.4e-06 26.1 0.1 0.062 12.6 0.0 3.4 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.6 CDF33364.1 - 7.6e-06 26.2 0.1 0.22 11.8 0.0 3.3 2 2 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CDF33364.1 - 9.2e-06 25.6 0.0 0.097 12.4 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDF33364.1 - 4e-05 23.3 1.5 0.11 12.3 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 CDF33364.1 - 0.00064 19.9 0.1 2.4 8.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDF33364.1 - 0.0017 18.7 0.1 3 8.3 0.0 3.4 3 0 0 3 3 3 1 RNA helicase AAA PF00004.29 CDF33364.1 - 0.0024 18.3 0.2 2.1 8.8 0.0 3.6 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 CDF33364.1 - 0.0025 17.1 0.0 0.77 8.9 0.0 2.2 2 0 0 2 2 2 1 G-protein alpha subunit IstB_IS21 PF01695.17 CDF33364.1 - 0.0032 17.2 0.4 0.52 10.0 0.0 3.5 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_30 PF13604.6 CDF33364.1 - 0.005 16.6 0.4 5.5 6.6 0.1 3.3 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDF33364.1 - 0.0088 16.6 0.0 8.1 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CDF33364.1 - 0.012 15.7 0.0 8.2 6.6 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase APS_kinase PF01583.20 CDF33364.1 - 0.02 14.8 0.0 6 6.7 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_28 PF13521.6 CDF33364.1 - 0.021 15.0 0.0 2.2 8.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CDF33364.1 - 0.029 13.5 0.1 7.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 CDF33364.1 - 0.03 14.0 0.0 7.9 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDF33364.1 - 0.034 14.1 0.0 9.9 6.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF3148 PF11347.8 CDF33364.1 - 0.035 13.8 0.0 4 7.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3148) AAA_23 PF13476.6 CDF33364.1 - 0.046 14.2 0.1 17 5.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF33364.1 - 0.048 12.8 0.1 2.3 7.3 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 CDF33364.1 - 0.052 12.9 0.0 3.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_21 PF13304.6 CDF33364.1 - 0.061 13.1 0.0 24 4.6 0.0 3.3 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 CDF33364.1 - 0.14 11.7 0.0 9.6 5.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 CDF33364.1 - 0.24 11.3 0.4 5 7.0 0.0 2.5 2 0 0 2 2 2 0 NACHT domain VirB3 PF05101.13 CDF33364.1 - 0.29 11.4 0.1 0.29 11.4 0.1 3.7 4 0 0 4 4 3 0 Type IV secretory pathway, VirB3-like protein Phage_int_SAM_1 PF02899.17 CDF33364.1 - 2.1 8.7 5.8 2 8.8 0.7 2.7 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain RcbX PF02341.15 CDF33365.1 - 1.5e-08 34.8 0.0 0.0091 16.3 0.0 2.8 2 2 0 2 2 2 2 RbcX protein ATP-synt_I PF03899.15 CDF33367.1 - 0.00043 20.6 4.3 0.00072 19.9 4.3 1.3 1 0 0 1 1 1 1 ATP synthase I chain AtpR PF12966.7 CDF33367.1 - 0.0039 17.6 0.4 0.0039 17.6 0.4 2.0 2 0 0 2 2 2 1 N-ATPase, AtpR subunit DUF3159 PF11361.8 CDF33367.1 - 0.013 15.3 0.6 1.7 8.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3159) Stm1_N PF09598.10 CDF33367.1 - 0.2 12.5 1.4 5.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Stm1 Ribosomal_L37e PF01907.19 CDF33368.1 - 1.9e-26 92.0 13.7 2.7e-26 91.5 13.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L37e SelR PF01641.18 CDF33368.1 - 0.014 15.5 0.3 0.018 15.1 0.3 1.2 1 0 0 1 1 1 0 SelR domain DZR PF12773.7 CDF33368.1 - 0.014 15.4 1.1 0.022 14.8 1.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 CDF33368.1 - 0.16 11.4 1.6 0.31 10.5 1.6 1.4 1 1 0 1 1 1 0 zinc-ribbon domain zn-ribbon_14 PF16503.5 CDF33368.1 - 0.67 9.5 4.7 1.5 8.4 0.5 2.2 2 0 0 2 2 2 0 Zinc-ribbon TH1 PF04858.13 CDF33369.1 - 2.2e-33 115.8 0.3 6e-33 114.3 0.3 1.5 1 1 0 1 1 1 1 TH1 protein PPIP5K2_N PF18086.1 CDF33370.1 - 6.2e-07 29.5 0.1 1e-06 28.8 0.1 1.4 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain DUF4317 PF14199.6 CDF33370.1 - 0.015 14.5 0.0 0.021 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) RimK PF08443.11 CDF33370.1 - 0.076 12.6 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Anoctamin PF04547.12 CDF33372.1 - 3.5e-35 121.7 0.0 3.6e-35 121.7 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel PSI_PsaJ PF01701.18 CDF33372.1 - 0.91 10.1 7.3 0.098 13.2 2.7 1.8 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IX / PsaJ Sel1 PF08238.12 CDF33373.1 - 2.9e-06 27.7 0.0 0.0054 17.4 0.0 3.2 3 0 0 3 3 3 2 Sel1 repeat Ribosomal_L35Ae PF01247.18 CDF33383.1 - 2.7e-19 69.1 0.4 3e-19 69.0 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae NTR PF01759.21 CDF33383.1 - 0.013 15.3 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 UNC-6/NTR/C345C module RimM PF01782.18 CDF33383.1 - 0.1 12.8 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 RimM N-terminal domain VCBS PF13517.6 CDF33384.1 - 5.3e-23 81.4 20.3 1.6e-10 41.4 4.6 5.5 4 2 3 7 7 7 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDF33384.1 - 1.5e-10 41.0 21.0 0.0058 16.7 0.2 5.7 6 0 0 6 6 6 5 FG-GAP repeat UnbV_ASPIC PF07593.12 CDF33384.1 - 1.5e-07 31.3 1.0 3.7e-07 30.0 1.0 1.7 1 0 0 1 1 1 1 ASPIC and UnbV EF-hand_5 PF13202.6 CDF33384.1 - 0.2 11.2 0.1 0.2 11.2 0.1 5.0 5 0 0 5 5 5 0 EF hand EF-hand_1 PF00036.32 CDF33384.1 - 7 6.4 15.4 17 5.2 0.1 5.1 5 0 0 5 5 5 0 EF hand EGF_MSP1_1 PF12946.7 CDF33388.1 - 0.026 14.6 1.2 0.14 12.3 1.2 2.3 1 0 0 1 1 1 0 MSP1 EGF domain 1 TFIIE-A_C PF11521.8 CDF33388.1 - 0.11 12.9 5.8 0.25 11.7 5.8 1.6 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha CENP-B_dimeris PF09026.10 CDF33388.1 - 0.19 12.1 8.7 0.18 12.2 6.5 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Nodulin_late PF07127.11 CDF33388.1 - 0.28 11.6 21.1 2.6 8.4 0.2 4.5 4 1 0 4 4 4 0 Late nodulin protein Cwf_Cwc_15 PF04889.12 CDF33388.1 - 7.2 6.3 11.9 13 5.4 11.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein UPF0126 PF03458.13 CDF33391.1 - 1.1e-39 134.1 16.9 2.7e-20 72.0 2.4 2.3 2 0 0 2 2 2 2 UPF0126 domain APH PF01636.23 CDF33393.1 - 7.6e-12 45.7 0.1 1.3e-11 44.8 0.1 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF33393.1 - 1.5e-06 28.0 0.0 3e-06 27.0 0.0 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 CDF33393.1 - 2.1e-05 24.0 0.1 0.046 13.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.14 CDF33393.1 - 0.0086 15.4 0.0 0.021 14.2 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 CDF33393.1 - 0.11 11.7 0.0 0.44 9.8 0.0 1.9 1 1 0 1 1 1 0 Protein tyrosine kinase UQ_con PF00179.26 CDF33395.1 - 1.2e-49 167.6 0.0 1.3e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF33395.1 - 2.2e-06 27.4 0.0 2.6e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B CPBP PF02517.16 CDF33399.1 - 5.2e-14 52.4 5.6 5.2e-14 52.4 5.6 2.8 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease AAA_33 PF13671.6 CDF33400.1 - 1.1e-11 45.1 1.2 4.4e-09 36.6 0.1 2.9 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDF33400.1 - 0.00022 21.8 0.3 0.054 14.0 0.3 2.3 1 1 0 1 1 1 1 AAA domain DUF5619 PF18505.1 CDF33400.1 - 0.074 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5619) Importin_rep_4 PF18808.1 CDF33403.1 - 2.3e-21 75.9 4.1 3.9e-19 68.7 0.0 4.0 4 0 0 4 4 4 1 Importin repeat HEAT_2 PF13646.6 CDF33403.1 - 5e-14 52.4 16.4 7.2e-06 26.3 0.0 8.5 7 2 4 11 11 11 6 HEAT repeats HEAT PF02985.22 CDF33403.1 - 5.6e-13 48.0 16.3 0.0015 18.6 0.0 10.4 12 0 0 12 12 11 3 HEAT repeat Cnd1 PF12717.7 CDF33403.1 - 2.3e-07 31.0 0.0 0.051 13.6 0.0 3.4 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDF33403.1 - 4.8e-07 30.3 0.0 0.11 13.2 0.0 5.1 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CDF33403.1 - 3.6e-06 27.4 25.5 0.0014 19.1 0.2 8.6 9 1 1 10 10 10 2 HEAT-like repeat Adaptin_N PF01602.20 CDF33403.1 - 0.00015 20.4 0.1 0.11 11.0 0.0 3.0 2 0 0 2 2 2 2 Adaptin N terminal region DUF3385 PF11865.8 CDF33403.1 - 0.00022 21.2 0.1 4.6 7.1 0.0 4.9 4 1 1 5 5 5 1 Domain of unknown function (DUF3385) Importin_rep_6 PF18829.1 CDF33403.1 - 0.0006 19.9 0.0 0.82 9.8 0.0 3.0 2 0 0 2 2 2 2 Importin repeat 6 MMS19_C PF12460.8 CDF33403.1 - 0.012 14.7 0.1 8 5.5 0.0 3.4 4 1 0 4 4 4 0 RNAPII transcription regulator C-terminal DNA_pol_phi PF04931.13 CDF33403.1 - 0.017 13.2 1.7 11 3.9 0.0 3.5 4 0 0 4 4 4 0 DNA polymerase phi Xpo1 PF08389.12 CDF33403.1 - 0.16 12.1 0.0 0.68 10.0 0.0 2.2 1 0 0 1 1 1 0 Exportin 1-like protein HEAT_PBS PF03130.16 CDF33403.1 - 2.7 8.9 8.2 68 4.6 0.0 6.7 8 1 0 8 8 5 0 PBS lyase HEAT-like repeat LRR_6 PF13516.6 CDF33404.1 - 3.4e-15 54.7 10.8 0.00011 21.9 0.0 7.8 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 CDF33404.1 - 6.6e-07 29.5 0.8 11 6.7 0.0 5.8 5 1 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDF33404.1 - 6.8e-06 25.9 0.2 8 7.4 0.0 6.0 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.6 CDF33404.1 - 2.3e-05 24.0 5.0 3.4 7.5 0.1 5.8 5 1 0 5 5 5 2 Leucine rich repeat ABC_tran PF00005.27 CDF33405.1 - 3.9e-26 92.2 0.0 5.9e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF33405.1 - 0.00028 20.8 0.2 0.071 12.9 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDF33405.1 - 0.089 12.5 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RT_RNaseH_2 PF17919.1 CDF33409.1 - 3.1e-23 81.7 0.0 6.9e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF33409.1 - 5.3e-14 52.4 0.0 1.1e-13 51.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF33409.1 - 3.5e-12 46.2 0.0 6.3e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF33409.1 - 1.2e-06 28.8 0.0 2.2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CDF33409.1 - 1.9e-05 24.3 0.0 3.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF243 PF03103.17 CDF33410.1 - 0.12 12.7 0.1 0.18 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF243) Plant_tran PF04827.14 CDF33411.1 - 1.5e-61 207.6 0.0 2e-61 207.2 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF33411.1 - 1.1e-06 28.4 0.0 1.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Rubis-subs-bind PF09273.11 CDF33413.1 - 7.5e-12 46.1 0.0 1.6e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Methyltrn_RNA_3 PF02598.17 CDF33414.1 - 0.24 10.9 0.0 0.25 10.8 0.0 1.0 1 0 0 1 1 1 0 Putative RNA methyltransferase DUF587 PF04532.12 CDF33417.1 - 0.089 12.1 0.0 0.091 12.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF587) DUF872 PF05915.12 CDF33418.1 - 3.1e-05 24.1 0.1 4.9e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) Copine PF07002.16 CDF33419.1 - 4e-60 203.0 0.0 5.7e-60 202.5 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 CDF33419.1 - 6.6e-16 58.5 0.0 3.3e-14 53.0 0.0 2.3 2 0 0 2 2 2 1 C2 domain vWA-TerF-like PF10138.9 CDF33419.1 - 2.2e-07 31.2 0.0 3.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus Ssl1 PF04056.14 CDF33421.1 - 2.4e-65 219.9 0.1 3.1e-65 219.6 0.1 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 CDF33421.1 - 3.2e-11 43.3 12.3 3.2e-11 43.3 12.3 3.3 3 1 0 3 3 3 1 TFIIH C1-like domain VWA_2 PF13519.6 CDF33421.1 - 1.2e-10 42.0 0.0 2.5e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain DZR PF12773.7 CDF33421.1 - 0.0015 18.5 6.3 0.36 10.9 6.3 2.7 1 1 0 1 1 1 1 Double zinc ribbon IBR PF01485.21 CDF33421.1 - 0.0034 17.6 4.8 0.0034 17.6 4.8 2.5 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain VWA_3 PF13768.6 CDF33421.1 - 0.0068 16.4 0.0 0.018 15.0 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain NOB1_Zn_bind PF08772.11 CDF33421.1 - 2.9 8.1 8.8 92 3.3 8.8 2.9 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Pkinase PF00069.25 CDF33422.1 - 9.5e-77 257.9 0.0 1.2e-76 257.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33422.1 - 2.7e-36 125.2 0.0 3.5e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 CDF33422.1 - 3.1e-08 34.1 0.0 5.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 CDF33422.1 - 3.2e-06 26.7 0.0 4.3e-06 26.3 0.0 1.3 1 1 0 1 1 1 1 Kinase-like PH_8 PF15409.6 CDF33422.1 - 0.00033 20.9 0.0 0.00064 20.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Kdo PF06293.14 CDF33422.1 - 0.006 15.9 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF33422.1 - 0.0086 14.9 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 CDF33422.1 - 0.16 11.6 0.2 0.45 10.1 0.2 1.7 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RCR PF12273.8 CDF33423.1 - 0.0016 19.1 0.1 0.0025 18.4 0.1 1.3 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Stevor PF17410.2 CDF33423.1 - 0.018 14.6 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF3330 PF11809.8 CDF33423.1 - 0.16 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) Vps16_C PF04840.12 CDF33424.1 - 4.5e-20 71.9 0.0 5.6e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 Vps16, C-terminal region Mito_carr PF00153.27 CDF33425.1 - 6.1e-56 186.3 1.4 1.7e-20 72.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein cNMP_binding PF00027.29 CDF33425.1 - 1.8e-36 124.1 0.0 7.7e-20 70.8 0.0 2.8 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Peptidase_C92 PF05708.12 CDF33425.1 - 2.1e-10 41.0 0.0 5.8e-07 29.7 0.0 2.9 3 0 0 3 3 3 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family EF-hand_1 PF00036.32 CDF33425.1 - 3.4e-06 26.2 0.2 5.9e-05 22.3 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 CDF33425.1 - 0.00046 19.9 0.4 0.0055 16.5 0.1 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 CDF33425.1 - 0.0042 16.5 0.0 0.012 15.1 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDF33425.1 - 0.0055 17.1 0.1 0.0055 17.1 0.1 3.0 2 1 0 2 2 2 1 EF-hand domain pair 14-3-3 PF00244.20 CDF33426.1 - 1.2e-101 338.9 6.8 1.4e-101 338.7 6.8 1.0 1 0 0 1 1 1 1 14-3-3 protein ARL2_Bind_BART PF11527.8 CDF33426.1 - 0.2 11.8 1.6 0.43 10.7 1.6 1.7 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART Vps39_2 PF10367.9 CDF33428.1 - 1.7e-17 63.9 0.0 8e-17 61.7 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 CDF33428.1 - 0.02 14.8 0.0 3 7.7 0.0 2.6 2 0 0 2 2 2 0 Region in Clathrin and VPS Vps39_1 PF10366.9 CDF33428.1 - 0.02 15.2 0.0 0.081 13.2 0.0 2.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 N6_N4_Mtase PF01555.18 CDF33430.1 - 3.6e-14 53.0 0.0 1.6e-12 47.6 0.0 2.2 1 1 0 1 1 1 1 DNA methylase SET PF00856.28 CDF33430.1 - 0.0062 16.9 0.0 0.042 14.2 0.0 2.3 1 1 0 1 1 1 1 SET domain N6-adenineMlase PF10237.9 CDF33430.1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase MethyltransfD12 PF02086.15 CDF33430.1 - 0.16 11.6 0.1 4.5 6.9 0.0 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Helicase_C PF00271.31 CDF33431.1 - 1.1e-14 54.7 0.0 2.6e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF33431.1 - 3.8e-08 33.3 0.0 1.1e-07 31.8 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 CDF33431.1 - 9.9e-06 26.0 0.2 5.9e-05 23.5 0.2 2.4 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D DDE_1 PF03184.19 CDF33433.1 - 2e-13 50.4 0.0 3.3e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 CDF33433.1 - 0.073 12.8 0.2 1.5 8.6 0.0 2.7 2 1 1 3 3 3 0 DDE superfamily endonuclease Aminotran_3 PF00202.21 CDF33434.1 - 2.6e-54 184.5 0.0 3.2e-53 180.8 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-III AAA_26 PF13500.6 CDF33434.1 - 6.8e-14 52.1 0.1 1.3e-13 51.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain Spermine_synth PF01564.17 CDF33436.1 - 2e-41 141.5 0.0 2.8e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CDF33436.1 - 6.2e-10 38.8 0.0 1.2e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CDF33436.1 - 0.024 15.3 0.0 0.046 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 CDF33436.1 - 0.072 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase WAP PF00095.21 CDF33442.1 - 0.0024 18.2 4.6 0.0064 16.8 4.6 1.8 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Lustrin_cystein PF14625.6 CDF33442.1 - 0.15 12.5 2.4 0.45 10.9 1.1 2.2 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain Dickkopf_N PF04706.12 CDF33442.1 - 0.94 10.0 8.4 0.16 12.5 4.1 2.0 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region DDE_3 PF13358.6 CDF33443.1 - 8.2e-13 48.3 0.0 1.1e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF33444.1 - 6.9e-07 29.0 0.2 1.4e-06 28.1 0.2 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF33444.1 - 8.6e-06 25.4 5.7 3.3e-05 23.5 0.2 3.0 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF33444.1 - 0.0016 18.2 3.0 0.066 13.0 0.0 2.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF33444.1 - 0.0022 18.2 3.5 0.0039 17.4 0.6 2.1 2 0 0 2 2 2 1 Transposase HTH_11 PF08279.12 CDF33444.1 - 0.0097 15.8 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 HTH domain GcrA PF07750.11 CDF33444.1 - 0.047 14.1 0.2 2.3 8.6 0.1 2.1 2 0 0 2 2 2 0 GcrA cell cycle regulator Epimerase PF01370.21 CDF33445.1 - 4.1e-23 82.1 0.0 5.6e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDF33445.1 - 2.2e-16 59.7 0.0 3.1e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CDF33445.1 - 7.3e-11 42.0 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CDF33445.1 - 7.4e-09 35.7 0.0 1.2e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CDF33445.1 - 2.6e-07 30.1 0.0 4.5e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 CDF33445.1 - 0.068 12.7 0.0 0.39 10.2 0.0 2.2 2 0 0 2 2 2 0 NmrA-like family UPF0086 PF01868.16 CDF33446.1 - 1.1e-21 76.6 0.4 2.1e-21 75.6 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function UPF0086 MccV PF17508.2 CDF33447.1 - 0.051 14.1 0.0 0.057 14.0 0.0 1.1 1 0 0 1 1 1 0 Microcin V bacteriocin PALP PF00291.25 CDF33448.1 - 1.9e-51 175.2 0.1 2.3e-51 174.9 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TPR_1 PF00515.28 CDF33449.1 - 2.4e-42 141.1 13.1 4.5e-08 32.6 0.0 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 CDF33449.1 - 1.4e-33 112.3 9.3 1.7e-05 24.6 0.1 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat STI1 PF17830.1 CDF33449.1 - 3.6e-31 106.8 15.6 2.7e-16 59.2 0.0 3.4 4 0 0 4 4 3 2 STI1 domain TPR_11 PF13414.6 CDF33449.1 - 6.3e-24 83.4 5.2 3.8e-09 36.1 0.1 5.7 3 2 3 6 6 6 4 TPR repeat TPR_8 PF13181.6 CDF33449.1 - 3.6e-22 76.6 12.5 5.7e-06 26.1 0.3 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33449.1 - 3.6e-17 61.6 0.3 0.046 14.6 0.2 6.4 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF33449.1 - 7.6e-16 57.3 3.3 0.00026 21.1 0.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF33449.1 - 9.2e-14 51.5 2.2 0.00022 21.5 0.0 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33449.1 - 1.2e-13 51.5 5.4 5.1e-05 23.8 0.0 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33449.1 - 1.7e-12 47.7 8.1 0.022 15.3 0.0 5.5 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDF33449.1 - 5.2e-11 41.8 0.1 0.00032 20.5 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF33449.1 - 1.4e-09 38.0 0.1 0.0058 16.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF33449.1 - 1.9e-09 37.5 1.4 0.0029 17.6 0.0 4.5 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CDF33449.1 - 5.1e-07 29.9 3.7 0.36 11.6 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDF33449.1 - 1.3e-06 28.0 0.8 0.96 9.4 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF33449.1 - 0.008 16.4 0.2 3.3 8.0 0.1 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CDF33449.1 - 0.011 15.0 0.3 3.6 6.7 0.0 3.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TssO PF17561.2 CDF33449.1 - 0.046 13.8 0.6 0.046 13.8 0.6 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO DUF3856 PF12968.7 CDF33449.1 - 0.057 13.5 0.3 3 7.9 0.1 3.0 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) GerD PF17898.1 CDF33449.1 - 0.18 11.8 7.0 1.1 9.3 4.6 3.4 3 2 1 4 4 4 0 Spore germination GerD central core domain MIT PF04212.18 CDF33449.1 - 0.94 9.6 5.6 44 4.2 0.2 4.4 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 CDF33449.1 - 1 9.0 9.4 27 4.4 2.3 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain GRDP-like PF07173.12 CDF33450.1 - 4.3e-21 76.1 8.0 1.7e-16 61.1 1.2 3.9 3 1 0 4 4 4 2 Glycine-rich domain-containing protein-like Nup96 PF12110.8 CDF33451.1 - 4.6e-27 94.9 0.0 4.1e-26 91.8 0.0 2.2 1 1 0 1 1 1 1 Nuclear protein 96 Motile_Sperm PF00635.26 CDF33453.1 - 1.4e-05 24.9 0.1 3.5e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF5489 PF17592.2 CDF33454.1 - 0.071 13.6 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5489) zf-4CXXC_R1 PF10497.9 CDF33457.1 - 0.0035 17.6 14.7 0.0078 16.4 14.7 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Myb_DNA-binding PF00249.31 CDF33458.1 - 3.4e-09 36.7 0.0 1e-08 35.2 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF33458.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Abi_C PF14355.6 CDF33458.1 - 0.076 13.1 0.0 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 Abortive infection C-terminus TPR_2 PF07719.17 CDF33459.1 - 1.1e-05 25.2 1.6 0.00027 20.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDF33459.1 - 0.00015 21.4 0.9 0.0013 18.5 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF33459.1 - 0.00049 20.2 0.1 0.088 13.0 0.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF33459.1 - 0.0013 18.9 0.1 0.0025 18.0 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDF33459.1 - 0.0016 18.7 0.1 0.0087 16.3 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33459.1 - 0.009 16.5 0.2 0.024 15.1 0.0 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TusA PF01206.17 CDF33459.1 - 0.017 14.9 0.0 0.06 13.2 0.0 1.9 2 0 0 2 2 2 0 Sulfurtransferase TusA TPR_14 PF13428.6 CDF33459.1 - 0.031 15.1 0.4 0.66 11.0 0.0 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDF33459.1 - 0.035 13.8 0.2 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.6 CDF33459.1 - 0.035 14.7 1.3 0.11 13.2 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDF33459.1 - 0.039 14.2 0.1 2.6 8.5 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 CDF33459.1 - 0.052 13.6 0.0 1.8 8.6 0.1 2.2 1 1 1 2 2 2 0 Putative TPR-like repeat Ribosomal_S26e PF01283.19 CDF33460.1 - 1.5e-40 138.0 8.9 1.7e-40 137.8 8.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e PYRIN PF02758.16 CDF33460.1 - 0.18 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain PUF PF00806.19 CDF33461.1 - 7.2e-67 217.5 1.1 1.7e-07 30.6 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 CDF33461.1 - 2e-05 25.0 0.0 0.26 11.6 0.0 3.6 2 1 1 3 3 3 3 CPL (NUC119) domain TetR_C_16 PF17920.1 CDF33461.1 - 0.099 12.9 0.1 34 4.7 0.0 3.5 3 2 2 5 5 5 0 Tetracyclin repressor-like, C-terminal domain PrmA PF06325.13 CDF33463.1 - 7.2e-63 212.7 0.0 9e-63 212.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CDF33463.1 - 5.4e-12 45.7 0.0 8e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF33463.1 - 1.2e-10 41.2 0.1 1.7e-10 40.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDF33463.1 - 1.6e-08 35.2 0.1 2.7e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF33463.1 - 3.8e-08 33.3 0.0 6.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF33463.1 - 5.8e-07 30.2 0.0 9.4e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDF33463.1 - 2.8e-06 27.3 0.1 3.8e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 CDF33463.1 - 8.7e-06 25.2 0.1 1.2e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Met_10 PF02475.16 CDF33463.1 - 0.00012 21.9 0.1 0.00018 21.3 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 CDF33463.1 - 0.00036 20.3 0.4 0.00093 18.9 0.4 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.6 CDF33463.1 - 0.00036 20.5 0.0 0.00054 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF33463.1 - 0.00037 21.1 0.1 0.00075 20.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDF33463.1 - 0.0015 18.2 0.1 0.0026 17.4 0.1 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_3 PF01596.17 CDF33463.1 - 0.003 16.8 0.0 0.0053 15.9 0.0 1.3 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.7 CDF33463.1 - 0.0034 17.3 0.0 0.0059 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CDF33463.1 - 0.0036 16.9 0.1 0.0053 16.4 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 CDF33463.1 - 0.098 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CDF33463.1 - 0.13 12.0 0.1 0.22 11.2 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Retrotran_gag_2 PF14223.6 CDF33464.1 - 8.9e-28 96.7 0.1 2.2e-27 95.4 0.0 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF33464.1 - 3.8e-12 46.4 0.1 1.6e-11 44.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF33464.1 - 7.7e-08 32.1 0.1 2.5e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF33464.1 - 0.0016 18.1 0.0 0.0035 17.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain CENP-C_mid PF15620.6 CDF33464.1 - 0.051 13.5 1.7 0.1 12.6 1.7 1.4 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region zf-CCHC_4 PF14392.6 CDF33464.1 - 0.19 11.5 1.8 0.53 10.1 1.8 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF33464.1 - 0.61 10.3 4.1 1.3 9.3 4.1 1.5 1 0 0 1 1 1 0 Zinc knuckle Dus PF01207.17 CDF33465.1 - 8.4e-67 225.5 0.0 1.1e-66 225.0 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 CDF33465.1 - 0.035 13.6 0.0 0.075 12.5 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein SOR_SNZ PF01680.17 CDF33465.1 - 0.035 13.9 0.2 0.094 12.5 0.2 1.7 1 1 1 2 2 2 0 SOR/SNZ family DHO_dh PF01180.21 CDF33465.1 - 0.048 12.9 0.0 0.81 8.8 0.0 2.1 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 CDF33465.1 - 0.074 12.4 0.0 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Thiamine monophosphate synthase FBPase PF00316.20 CDF33468.1 - 7.7e-17 61.4 0.2 2.1e-16 60.0 0.0 1.8 3 0 0 3 3 3 1 Fructose-1-6-bisphosphatase, N-terminal domain BCDHK_Adom3 PF10436.9 CDF33470.1 - 2e-46 157.8 0.0 3e-46 157.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CDF33470.1 - 2.6e-09 37.6 0.0 5.3e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDF33470.1 - 0.0018 18.1 0.0 0.0032 17.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S10 PF00338.22 CDF33471.1 - 2.3e-29 101.5 0.2 2.7e-29 101.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e UB2H PF14814.6 CDF33471.1 - 0.045 13.8 0.0 11 6.1 0.0 2.2 2 0 0 2 2 2 0 Bifunctional transglycosylase second domain DUF3929 PF13066.6 CDF33471.1 - 0.05 13.7 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3929) UbiA PF01040.18 CDF33472.1 - 5.5e-49 166.7 17.2 8.9e-49 166.1 17.2 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4370 PF14290.6 CDF33473.1 - 3.2e-08 33.7 0.3 3.8e-08 33.5 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4370) DUF2498 PF10692.9 CDF33473.1 - 0.017 15.0 0.2 6 6.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2498) MGDG_synth PF06925.11 CDF33474.1 - 6.2e-26 91.5 0.0 8.6e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 CDF33474.1 - 2.9e-08 33.9 0.0 4.6e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 CDF33474.1 - 1.4e-06 28.7 0.1 6e-06 26.7 0.1 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Tim44 PF04280.15 CDF33476.1 - 1.7e-36 125.6 0.1 5.7e-36 123.8 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain MGDG_synth PF06925.11 CDF33477.1 - 1.9e-18 67.1 0.0 3.1e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 CDF33477.1 - 8e-11 42.2 0.0 1.1e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 CDF33477.1 - 5.2e-05 23.7 0.1 0.00015 22.2 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 PAP_fibrillin PF04755.12 CDF33479.1 - 6.3e-26 91.5 0.0 1.4e-25 90.4 0.0 1.6 1 1 0 1 1 1 1 PAP_fibrillin Mpp10 PF04006.12 CDF33480.1 - 6.1e-71 239.7 32.9 1.2e-55 189.1 11.9 2.2 1 1 1 2 2 2 2 Mpp10 protein OFCC1 PF15680.5 CDF33480.1 - 0.036 14.6 3.1 0.27 11.8 0.5 2.9 2 0 0 2 2 2 0 Orofacial cleft 1 candidate gene 1 protein HemY_N PF07219.13 CDF33480.1 - 0.44 10.8 2.7 4.1 7.6 0.0 2.8 2 0 0 2 2 2 0 HemY protein N-terminus ATP-synt_DE PF00401.20 CDF33480.1 - 2.6 8.4 9.1 1.5 9.2 6.0 2.3 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain eRF1_3 PF03465.15 CDF33481.1 - 9.2e-27 93.8 0.0 1.7e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 CDF33481.1 - 3.4e-18 66.2 0.1 5.3e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 DUF1541 PF07563.11 CDF33482.1 - 0.95 9.4 5.8 88 3.1 3.1 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1541) WD40 PF00400.32 CDF33484.1 - 1e-30 105.3 16.5 1.2e-05 25.9 0.0 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33484.1 - 1.9e-17 63.4 0.0 0.051 13.9 0.0 6.2 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF33484.1 - 9.5e-05 21.5 1.0 0.12 11.3 0.1 4.0 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 CDF33484.1 - 0.00063 18.8 0.0 0.29 10.0 0.0 3.3 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 CDF33484.1 - 0.057 11.9 0.1 7.4 5.0 0.0 3.0 3 0 0 3 3 3 0 Cytochrome D1 heme domain BNIP2 PF12496.8 CDF33484.1 - 0.95 9.9 4.5 1.7 9.1 4.5 1.4 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Ribosomal_S9 PF00380.19 CDF33485.1 - 1.6e-45 154.5 0.1 2.1e-45 154.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Bromodomain PF00439.25 CDF33487.1 - 3.2e-18 65.6 0.1 7e-18 64.5 0.1 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CDF33487.1 - 4e-11 43.2 0.0 8.3e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF33487.1 - 1.9e-07 31.1 0.0 4.6e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF33487.1 - 7.4e-06 26.3 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF33487.1 - 0.0086 16.0 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein DUF974 PF06159.13 CDF33488.1 - 9.5e-34 117.3 0.0 4.8e-29 101.9 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF974) Trs65 PF12735.7 CDF33488.1 - 1.5e-05 24.6 3.0 6.4e-05 22.5 0.1 2.5 3 0 0 3 3 3 1 TRAPP trafficking subunit Trs65 Alpha_adaptinC2 PF02883.20 CDF33488.1 - 0.042 14.1 0.7 0.087 13.1 0.7 1.4 1 0 0 1 1 1 0 Adaptin C-terminal domain Tubulin PF00091.25 CDF33490.1 - 2.3e-65 220.5 0.0 3.6e-65 219.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDF33490.1 - 4.3e-41 140.0 0.0 6.6e-41 139.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDF33490.1 - 0.0039 16.9 0.0 0.0085 15.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CDF33490.1 - 0.069 12.3 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 Tubulin like CBS PF00571.28 CDF33491.1 - 2.4e-22 79.1 1.0 4.8e-11 42.9 0.3 2.7 2 0 0 2 2 2 2 CBS domain DHH PF01368.20 CDF33491.1 - 6.5e-10 39.2 0.1 1.2e-09 38.2 0.1 1.4 1 0 0 1 1 1 1 DHH family DHHA1 PF02272.19 CDF33491.1 - 0.00013 22.4 0.0 0.00031 21.2 0.0 1.5 1 0 0 1 1 1 1 DHHA1 domain H_kinase_N PF12282.8 CDF33491.1 - 0.028 14.4 0.1 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Signal transduction histidine kinase PSD4 PF07631.11 CDF33491.1 - 0.14 12.7 0.1 0.27 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) SRP_SPB PF02978.19 CDF33492.1 - 2.3e-05 24.9 0.2 0.0002 21.9 0.0 2.3 1 1 1 2 2 2 1 Signal peptide binding domain CAF1 PF04857.20 CDF33493.1 - 3.6e-37 128.2 0.0 4.8e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Fer2_BFD PF04324.15 CDF33493.1 - 0.48 10.8 2.6 3.1 8.2 0.1 3.2 3 0 0 3 3 3 0 BFD-like [2Fe-2S] binding domain Ribosomal_L27e PF01777.18 CDF33494.1 - 1.1e-27 96.2 0.2 1.9e-27 95.4 0.2 1.4 1 1 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 CDF33494.1 - 0.021 14.8 0.1 0.049 13.6 0.1 1.6 1 0 0 1 1 1 0 KOW motif zf-SAP30 PF13866.6 CDF33494.1 - 0.065 13.4 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 SAP30 zinc-finger Glyco_hydro_63 PF03200.16 CDF33494.1 - 0.1 11.4 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain Ribosomal_S5_C PF03719.15 CDF33495.1 - 3e-21 74.7 0.0 6.1e-21 73.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CDF33495.1 - 1.7e-20 72.8 0.5 3.1e-20 71.9 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Nucleopor_Nup85 PF07575.13 CDF33496.1 - 4.6e-50 170.8 0.0 6.3e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Nup85 Nucleoporin Nup84_Nup100 PF04121.13 CDF33496.1 - 0.056 11.6 0.5 0.1 10.7 0.2 1.5 2 0 0 2 2 2 0 Nuclear pore protein 84 / 107 DUF4042 PF13251.6 CDF33498.1 - 1.2e-14 54.5 0.6 4.5e-14 52.6 0.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4042) Hydrolase_3 PF08282.12 CDF33500.1 - 6.7e-34 117.8 0.0 7.7e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDF33500.1 - 9.6e-12 44.9 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDF33500.1 - 1.6e-07 31.9 0.3 2.8e-07 31.0 0.4 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDF33500.1 - 0.0045 17.1 0.0 0.0063 16.6 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 CDF33500.1 - 0.0077 15.4 0.0 0.016 14.4 0.0 1.4 1 1 0 1 1 1 1 Trehalose-phosphatase Hydrolase_like PF13242.6 CDF33500.1 - 0.04 14.0 0.1 0.092 12.8 0.1 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Pkinase PF00069.25 CDF33501.1 - 1.2e-63 215.0 0.0 1.4e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33501.1 - 1.8e-43 148.7 0.0 2.4e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF33501.1 - 1.4e-07 30.7 0.0 2e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase PBD PF00786.28 CDF33501.1 - 3.8e-06 27.1 0.0 8.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Haspin_kinase PF12330.8 CDF33501.1 - 0.084 11.8 0.0 0.75 8.7 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain FBPase PF00316.20 CDF33502.1 - 1.3e-61 207.4 0.6 1.7e-61 207.0 0.6 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CDF33502.1 - 0.064 12.8 0.0 0.77 9.2 0.0 2.0 2 0 0 2 2 2 0 Inositol monophosphatase family Glyco_transf_20 PF00982.21 CDF33503.1 - 9.3e-195 647.8 0.0 1.2e-194 647.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CDF33503.1 - 1e-49 168.8 0.0 1.4e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 Trehalose-phosphatase Glycos_transf_1 PF00534.20 CDF33503.1 - 0.00011 21.8 0.0 0.00045 19.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Bac_surface_Ag PF01103.23 CDF33504.1 - 4.9e-40 138.0 0.0 5.6e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 Surface antigen GAT PF03127.14 CDF33506.1 - 0.0049 17.1 2.2 0.0087 16.3 2.2 1.4 1 0 0 1 1 1 1 GAT domain Hexapep PF00132.24 CDF33509.1 - 1.5e-13 49.8 6.6 7.3e-05 22.3 1.0 3.6 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDF33509.1 - 0.005 16.6 4.7 0.01 15.6 0.3 3.0 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase Ribosomal_L36e PF01158.18 CDF33510.1 - 6.3e-38 128.9 6.9 6.8e-38 128.8 6.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e HEAT_EZ PF13513.6 CDF33511.1 - 1.4e-07 31.8 0.1 1.4e-07 31.8 0.1 6.1 6 1 0 6 6 6 1 HEAT-like repeat HEAT PF02985.22 CDF33511.1 - 1.5e-06 28.0 18.1 0.24 11.8 0.0 7.8 8 0 0 8 8 8 3 HEAT repeat UME PF08064.13 CDF33511.1 - 4e-06 26.7 0.6 0.062 13.2 0.1 4.7 2 2 2 4 4 4 2 UME (NUC010) domain IFRD PF05004.13 CDF33511.1 - 2.1e-05 23.8 7.4 0.67 9.0 0.1 4.8 3 2 2 5 5 5 3 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 CDF33511.1 - 0.00028 21.2 13.2 0.056 13.8 0.5 4.8 3 1 3 6 6 6 4 HEAT repeats Vac14_Fab1_bd PF12755.7 CDF33511.1 - 0.012 16.2 1.4 3 8.5 0.1 4.8 4 2 1 6 6 6 0 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 CDF33511.1 - 0.077 12.8 0.4 7.2 6.4 0.0 3.7 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) TetR_C_15 PF17918.1 CDF33511.1 - 1.3 9.8 8.5 12 6.7 0.4 3.7 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Mito_carr PF00153.27 CDF33513.1 - 2.2e-40 136.4 0.1 4.5e-19 68.2 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein eIF-5_eIF-2B PF01873.17 CDF33515.1 - 0.0018 18.1 0.1 0.003 17.4 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 NMT PF01233.19 CDF33516.1 - 1.3e-22 80.4 0.1 1.3e-22 80.3 0.1 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Fumble PF03630.14 CDF33518.1 - 2.3e-72 243.9 0.0 3e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 Fumble DEAD PF00270.29 CDF33519.1 - 2.8e-21 76.1 0.0 3.8e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF33519.1 - 7.2e-12 45.6 0.0 9.8e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 CDF33519.1 - 0.0018 18.7 0.2 0.02 15.3 0.2 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF33519.1 - 0.0038 17.5 0.0 0.012 15.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDF33519.1 - 0.035 13.2 0.0 0.065 12.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein BTB PF00651.31 CDF33520.1 - 1.2e-08 35.2 0.0 1.9e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CDF33520.1 - 0.0065 16.6 0.1 0.013 15.6 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch DUF4194 PF13835.6 CDF33520.1 - 0.03 14.1 0.1 0.055 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) Elong_Iki1 PF10483.9 CDF33521.1 - 7.6e-06 25.6 0.1 0.00023 20.7 0.2 2.0 2 0 0 2 2 2 2 Elongator subunit Iki1 Pkinase PF00069.25 CDF33522.1 - 5.9e-41 140.6 0.0 8.4e-41 140.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33522.1 - 3.1e-20 72.6 0.0 4.3e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF33522.1 - 0.00016 21.1 0.0 0.00023 20.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF33522.1 - 0.0069 15.8 0.0 0.01 15.2 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Y_phosphatase2 PF03162.13 CDF33523.1 - 6.9e-37 126.6 0.0 9e-37 126.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 CDF33523.1 - 0.00016 21.8 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 CDF33523.1 - 0.032 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase polyprenyl_synt PF00348.17 CDF33524.1 - 1e-82 277.1 0.1 1.3e-82 276.8 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase RNA_pol_Rpc4 PF05132.14 CDF33525.1 - 3.1e-10 40.6 0.6 1.2e-09 38.7 0.4 2.0 2 1 0 2 2 2 1 RNA polymerase III RPC4 Exo_endo_phos PF03372.23 CDF33526.1 - 9.1e-25 87.5 0.1 1.5e-24 86.8 0.1 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CDF33526.1 - 0.064 13.1 0.0 0.65 9.8 0.0 2.3 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase RNB PF00773.19 CDF33527.1 - 3.6e-93 312.5 0.0 5.9e-93 311.8 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 CDF33527.1 - 2.5e-16 59.5 0.0 7.6e-16 57.9 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 CDF33527.1 - 1.7e-13 50.5 0.0 3.5e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 CDF33527.1 - 9.7e-08 31.9 0.1 2.5e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 S1 domain CSD2 PF17876.1 CDF33527.1 - 7.2e-06 26.1 1.1 0.00033 20.8 0.0 3.1 3 0 0 3 3 3 1 Cold shock domain Phosducin PF02114.16 CDF33528.1 - 3.7e-17 62.1 0.1 4.5e-17 61.9 0.1 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 CDF33528.1 - 0.00016 21.6 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Spore_III_AF PF09581.10 CDF33528.1 - 0.054 13.5 2.1 0.073 13.1 1.1 1.6 1 1 1 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) RNase_J_C PF17770.1 CDF33528.1 - 0.099 13.7 0.3 0.21 12.6 0.3 1.6 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain Ribosomal_S24e PF01282.19 CDF33529.1 - 1.4e-32 111.5 0.0 2e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S24e cwf18 PF08315.12 CDF33530.1 - 2.8e-21 76.6 5.4 3.4e-21 76.3 5.4 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Arf PF00025.21 CDF33531.1 - 1.1e-62 210.6 0.1 1.2e-62 210.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CDF33531.1 - 1.8e-12 47.1 0.4 1.2e-06 28.0 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CDF33531.1 - 2.3e-12 47.2 0.0 3.3e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDF33531.1 - 1.3e-10 41.1 0.0 1.6e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDF33531.1 - 7.5e-09 35.3 0.0 9.1e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDF33531.1 - 1.2e-08 35.0 0.0 1.9e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF33531.1 - 4.4e-07 29.5 0.0 5.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDF33531.1 - 0.0012 18.4 0.0 0.046 13.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 CDF33531.1 - 0.026 14.1 0.0 0.49 10.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CDF33531.1 - 0.061 13.0 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 CDF33531.1 - 0.064 12.8 0.0 0.19 11.2 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 CDF33531.1 - 0.081 12.7 0.0 0.21 11.4 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Phytase-like PF13449.6 CDF33531.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 Esterase-like activity of phytase MTBP_N PF14918.6 CDF33531.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 MDM2-binding SPRY PF00622.28 CDF33532.1 - 0.00038 20.6 0.0 0.00083 19.5 0.0 1.5 1 0 0 1 1 1 1 SPRY domain MspA PF09203.11 CDF33532.1 - 0.042 13.7 0.2 0.3 10.9 0.3 1.8 1 1 1 2 2 2 0 MspA Toxin_ToxA PF11584.8 CDF33534.1 - 0.0092 16.0 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Proteinaceous host-selective toxin ToxA RRM_1 PF00076.22 CDF33535.1 - 4.9e-21 74.3 0.0 6.5e-21 73.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF33535.1 - 0.00081 19.5 0.0 0.0017 18.4 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif Mg_trans_NIPA PF05653.14 CDF33536.1 - 7.2e-17 61.4 6.8 2.3e-09 36.8 0.4 2.0 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CDF33536.1 - 0.00023 21.4 1.3 0.00023 21.4 1.3 3.0 2 1 0 2 2 2 1 EamA-like transporter family DUF5592 PF17332.2 CDF33536.1 - 0.065 13.8 0.8 0.87 10.2 0.2 2.8 3 1 0 3 3 3 0 Family of unknown function (DUF5592) DUF2919 PF11143.8 CDF33536.1 - 0.23 11.8 6.7 0.072 13.4 3.5 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2919) SdpI PF13630.6 CDF33536.1 - 0.28 11.3 0.1 0.28 11.3 0.1 3.0 3 0 0 3 3 3 0 SdpI/YhfL protein family TssN PF17555.2 CDF33536.1 - 8.1 5.7 14.9 1.3 8.4 2.0 2.3 2 0 0 2 2 2 0 Type VI secretion system, TssN FKBP_C PF00254.28 CDF33538.1 - 0.027 14.8 0.0 0.04 14.2 0.0 1.2 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase Flavokinase PF01687.17 CDF33539.1 - 2.7e-30 104.9 0.0 3.3e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase PAP_fibrillin PF04755.12 CDF33540.1 - 1.3e-27 97.1 0.0 1.1e-26 94.0 0.0 1.9 1 1 0 1 1 1 1 PAP_fibrillin Cupin_8 PF13621.6 CDF33541.1 - 7.6e-15 55.3 0.0 1.2e-14 54.7 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Polbeta PF18765.1 CDF33541.1 - 1.1e-05 25.4 0.1 2.6e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 CDF33541.1 - 1.7e-05 25.0 0.1 3.7e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cupin_4 PF08007.12 CDF33541.1 - 0.048 13.1 0.0 0.13 11.7 0.0 1.7 1 1 0 1 1 1 0 Cupin superfamily protein Adenyl_cycl_N PF12633.7 CDF33541.1 - 0.062 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase NT domain Peptidase_M41 PF01434.18 CDF33542.1 - 1.5e-67 227.2 0.0 2.6e-67 226.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CDF33542.1 - 1.3e-45 155.0 0.0 2.6e-45 154.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF33542.1 - 2.2e-11 43.4 0.0 5e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDF33542.1 - 1.8e-05 24.8 0.6 9.1e-05 22.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDF33542.1 - 0.00019 20.7 0.0 0.0004 19.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain PhoH PF02562.16 CDF33542.1 - 0.00042 19.8 0.3 0.42 10.0 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein RuvB_N PF05496.12 CDF33542.1 - 0.00043 20.1 0.0 0.0023 17.7 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF33542.1 - 0.00051 20.5 0.2 0.034 14.5 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain FtsH_ext PF06480.15 CDF33542.1 - 0.0041 17.5 0.2 0.011 16.1 0.0 1.8 2 0 0 2 2 1 1 FtsH Extracellular AAA_33 PF13671.6 CDF33542.1 - 0.014 15.6 0.0 0.029 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDF33542.1 - 0.022 15.3 0.0 0.051 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDF33542.1 - 0.026 14.3 0.0 0.061 13.1 0.0 1.6 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 CDF33542.1 - 0.029 14.7 0.7 0.3 11.4 0.0 2.5 2 1 0 3 3 2 0 AAA domain AAA_2 PF07724.14 CDF33542.1 - 0.03 14.4 0.0 0.088 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 CDF33542.1 - 0.037 13.4 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDF33542.1 - 0.046 14.0 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDF33542.1 - 0.052 13.5 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CDF33542.1 - 0.064 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3670 PF12419.8 CDF33542.1 - 0.096 12.5 0.1 11 5.9 0.0 2.8 2 0 0 2 2 2 0 SNF2 Helicase protein NACHT PF05729.12 CDF33542.1 - 0.13 12.2 0.1 0.41 10.6 0.0 1.9 2 0 0 2 2 2 0 NACHT domain TFIID_20kDa PF03847.13 CDF33543.1 - 1.1e-27 96.3 0.1 1.5e-27 95.9 0.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 CDF33543.1 - 2e-05 24.8 0.0 2.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDF33543.1 - 0.0011 19.4 0.0 0.0018 18.6 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 CDF33543.1 - 0.011 15.8 0.2 0.19 11.8 0.1 2.1 1 1 1 2 2 2 0 Transcription initiation factor IID, 18kD subunit TAF PF02969.17 CDF33543.1 - 0.014 15.5 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) RNA_pol_Rpb1_1 PF04997.12 CDF33543.1 - 0.077 12.3 0.0 0.099 12.0 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 ABC_tran PF00005.27 CDF33544.1 - 1e-52 178.3 1.2 1.4e-25 90.4 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDF33544.1 - 1.1e-26 92.7 9.9 5e-22 77.7 3.9 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDF33544.1 - 2.3e-12 47.4 3.7 0.0049 16.7 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF33544.1 - 7.2e-08 32.1 1.3 0.44 9.9 0.2 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDF33544.1 - 1.7e-07 31.6 2.0 0.0016 18.7 0.1 3.8 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 CDF33544.1 - 2.6e-07 30.7 0.3 0.041 13.6 0.0 3.8 3 2 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CDF33544.1 - 4.3e-07 29.6 0.3 0.0019 17.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF33544.1 - 8.8e-06 26.2 0.8 0.11 12.9 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 CDF33544.1 - 3.5e-05 24.1 0.2 0.17 12.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CDF33544.1 - 6.2e-05 23.1 0.3 0.0068 16.5 0.1 3.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 CDF33544.1 - 7.7e-05 22.5 0.1 0.012 15.4 0.1 3.0 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 CDF33544.1 - 0.00039 20.2 0.0 0.49 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 CDF33544.1 - 0.00078 19.9 0.1 0.91 9.9 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDF33544.1 - 0.00099 19.1 0.5 1.7 8.5 0.0 2.7 2 0 0 2 2 2 2 NACHT domain RsgA_GTPase PF03193.16 CDF33544.1 - 0.0014 18.6 0.1 0.046 13.6 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase Mg_chelatase PF01078.21 CDF33544.1 - 0.0016 17.9 0.2 2 7.8 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDF33544.1 - 0.0032 17.6 0.3 2.6 8.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CDF33544.1 - 0.0042 17.1 0.1 0.86 9.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 CDF33544.1 - 0.0043 16.7 0.2 1.2 8.8 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 CDF33544.1 - 0.0056 16.7 2.2 0.017 15.2 0.0 2.9 4 0 0 4 4 2 1 Dynamin family DLIC PF05783.11 CDF33544.1 - 0.0056 15.6 4.6 0.059 12.2 0.0 3.2 3 0 0 3 3 3 1 Dynein light intermediate chain (DLIC) TsaE PF02367.17 CDF33544.1 - 0.0071 16.3 0.1 2 8.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CDF33544.1 - 0.0094 16.2 0.0 0.38 11.0 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 CDF33544.1 - 0.014 14.9 0.0 6.9 6.1 0.0 2.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_23 PF13476.6 CDF33544.1 - 0.029 14.9 0.1 0.029 14.9 0.1 4.5 5 1 0 5 5 4 0 AAA domain PduV-EutP PF10662.9 CDF33544.1 - 0.029 14.1 0.3 6.8 6.4 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 CDF33544.1 - 0.032 13.5 0.0 1.1 8.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 CDF33544.1 - 0.065 12.8 0.4 3.6 7.1 0.0 3.4 4 0 0 4 4 4 0 AAA domain NTPase_1 PF03266.15 CDF33544.1 - 0.088 12.7 0.7 22 4.9 0.0 4.0 5 0 0 5 5 4 0 NTPase SRP54 PF00448.22 CDF33544.1 - 0.09 12.4 0.2 4.9 6.7 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Rad17 PF03215.15 CDF33544.1 - 0.15 12.0 0.1 28 4.5 0.0 2.7 3 0 0 3 3 2 0 Rad17 P-loop domain IstB_IS21 PF01695.17 CDF33544.1 - 0.2 11.3 0.3 6.4 6.5 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_27 PF13514.6 CDF33544.1 - 0.56 9.8 0.0 0.56 9.8 0.0 2.8 4 0 0 4 4 3 0 AAA domain Tho1_MOS11_C PF18592.1 CDF33544.1 - 0.74 9.7 6.7 22 4.9 0.1 2.9 2 0 0 2 2 2 0 Tho1/MOS11 C-terminal domain tRNA-synt_1b PF00579.25 CDF33545.1 - 1.1e-84 284.3 0.0 1.3e-84 284.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) MecA_N PF05223.11 CDF33545.1 - 0.16 12.2 0.0 14 6.0 0.0 2.8 3 0 0 3 3 3 0 NTF2-like N-terminal transpeptidase domain Mito_carr PF00153.27 CDF33546.1 - 3.1e-59 196.9 0.3 7.5e-21 73.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDF33546.1 - 0.011 14.9 0.0 0.86 8.7 0.0 2.2 2 0 0 2 2 2 0 Gammaproteobacterial serine protease NETI PF14044.6 CDF33546.1 - 0.16 11.7 0.1 6.8 6.5 0.0 2.3 2 0 0 2 2 2 0 NETI protein Tfb4 PF03850.14 CDF33548.1 - 1.7e-66 224.5 0.1 2e-66 224.3 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 zf-C2H2_6 PF13912.6 CDF33548.1 - 0.13 12.3 1.0 9.5 6.4 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger MMR_HSR1 PF01926.23 CDF33550.1 - 5.1e-18 65.2 0.0 1.6e-15 57.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GN3L_Grn1 PF08701.11 CDF33550.1 - 5.1e-17 61.7 18.2 5.1e-17 61.7 18.2 2.0 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase FeoB_N PF02421.18 CDF33550.1 - 9.3e-08 31.7 0.0 6.3e-07 29.1 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDF33550.1 - 5.5e-06 26.4 0.0 0.0011 19.0 0.0 2.5 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 CDF33550.1 - 2.4e-05 23.9 0.3 0.021 14.4 0.0 3.5 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 CDF33550.1 - 0.0016 17.8 0.0 0.011 15.1 0.0 2.2 2 0 0 2 2 2 1 AIG1 family AAA_18 PF13238.6 CDF33550.1 - 0.037 14.6 0.1 0.16 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 CDF33550.1 - 0.051 12.5 3.2 1.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 CDF33550.1 - 0.051 13.6 3.5 0.31 11.1 0.1 3.0 3 1 1 4 4 4 0 Dynamin family AAA_16 PF13191.6 CDF33550.1 - 0.12 12.7 0.7 0.91 9.9 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_11 PF13086.6 CDF33550.1 - 0.16 11.7 2.3 0.41 10.4 2.3 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF33550.1 - 0.37 11.3 1.4 1.6 9.3 0.0 2.5 2 1 0 2 2 2 0 ABC transporter SMC_N PF02463.19 CDF33551.1 - 9e-63 211.6 1.0 1.3e-62 211.2 1.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDF33551.1 - 1.8e-27 96.0 0.0 5.2e-27 94.5 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CDF33551.1 - 3.8e-13 49.9 0.4 1.2e-06 28.6 0.0 3.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDF33551.1 - 6.8e-09 35.3 0.0 1.9e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CDF33551.1 - 9.2e-09 35.5 0.3 9.2e-09 35.5 0.3 3.4 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CDF33551.1 - 8.5e-06 26.4 34.9 8.5e-06 26.4 34.9 5.4 2 2 0 2 2 2 1 AAA domain Laminin_II PF06009.12 CDF33551.1 - 0.00083 19.4 1.0 0.00083 19.4 1.0 7.3 3 3 7 10 10 10 2 Laminin Domain II DUF948 PF06103.11 CDF33551.1 - 0.63 10.3 23.3 0.96 9.8 0.2 6.3 5 3 0 5 5 5 0 Bacterial protein of unknown function (DUF948) ABC_tran PF00005.27 CDF33551.1 - 4.3 7.9 30.3 0.15 12.5 1.3 6.5 4 3 0 4 4 4 0 ABC transporter FAD_binding_3 PF01494.19 CDF33552.1 - 5.1e-20 72.0 0.0 1.1e-19 70.9 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CDF33552.1 - 0.00076 18.7 0.1 0.0012 18.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CDF33552.1 - 0.0025 18.0 0.7 0.012 15.9 0.7 2.2 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CDF33552.1 - 0.026 13.6 0.0 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 CDF33552.1 - 0.081 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDF33552.1 - 0.094 13.3 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDF33552.1 - 0.12 11.6 0.1 0.18 11.0 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PAP2 PF01569.21 CDF33553.1 - 3.9e-26 91.4 3.5 3.9e-26 91.4 3.5 1.8 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 CDF33553.1 - 0.0092 15.7 12.0 0.63 9.7 5.8 3.2 1 1 1 2 2 2 2 PAP2 superfamily Peptidase_U4 PF03419.13 CDF33553.1 - 0.43 9.8 2.2 3.3 6.9 0.1 2.1 2 0 0 2 2 2 0 Sporulation factor SpoIIGA PAP2_C PF14360.6 CDF33553.1 - 0.51 10.9 3.0 3.7 8.2 3.0 2.4 1 1 0 1 1 1 0 PAP2 superfamily C-terminal Sulf_transp PF04143.14 CDF33555.1 - 9.9e-07 28.6 26.9 4.6e-05 23.1 12.5 3.1 2 2 0 3 3 3 2 Sulphur transport E1-E2_ATPase PF00122.20 CDF33556.1 - 6.9e-22 77.8 0.0 6.9e-22 77.8 0.0 2.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CDF33556.1 - 1.8e-14 54.6 0.3 7.3e-07 29.7 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF33556.1 - 0.0044 17.1 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CDF33556.1 - 0.07 12.9 0.1 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Gp5_C PF06715.12 CDF33556.1 - 0.45 10.8 3.9 7.3 7.0 0.2 3.1 3 0 0 3 3 3 0 Gp5 C-terminal repeat (3 copies) adh_short PF00106.25 CDF33557.1 - 2.6e-26 92.3 0.0 1.1e-20 74.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDF33557.1 - 2.5e-11 43.6 0.0 2.9e-08 33.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF33557.1 - 3.7e-05 23.7 0.0 6.4e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDF33557.1 - 0.026 14.0 0.3 0.045 13.2 0.0 1.4 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family tRNA-synt_1b PF00579.25 CDF33558.1 - 0.18 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) SPT6_acidic PF14632.6 CDF33558.1 - 2.2 8.9 12.3 0.12 12.9 6.7 1.8 2 0 0 2 2 2 0 Acidic N-terminal SPT6 NECFESHC PF16621.5 CDF33559.1 - 0.096 12.7 1.5 0.23 11.4 1.5 1.7 1 0 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 RNase_PH PF01138.21 CDF33561.1 - 1.1e-17 64.8 0.1 1.7e-17 64.2 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF33561.1 - 0.00046 20.2 0.2 0.001 19.1 0.2 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Bromodomain PF00439.25 CDF33563.1 - 2e-19 69.5 0.0 3.9e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain GATA PF00320.27 CDF33563.1 - 1.2e-06 28.0 3.2 3.2e-06 26.6 3.2 1.8 1 0 0 1 1 1 1 GATA zinc finger tRNA-synt_1c PF00749.21 CDF33565.1 - 6.4e-97 324.2 0.2 8.2e-97 323.9 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CDF33565.1 - 1.6e-30 106.3 2.8 4.7e-30 104.7 0.4 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain DSS1_SEM1 PF05160.13 CDF33565.1 - 0.0013 18.7 1.0 0.0075 16.3 1.0 2.3 1 0 0 1 1 1 1 DSS1/SEM1 family AAA_33 PF13671.6 CDF33565.1 - 0.045 13.9 0.6 0.84 9.8 0.2 2.4 2 0 0 2 2 2 0 AAA domain U1snRNP70_N PF12220.8 CDF33565.1 - 0.22 12.2 1.5 0.46 11.2 0.3 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Helicase_C_2 PF13307.6 CDF33567.1 - 1.5e-53 181.5 0.0 2.5e-53 180.8 0.0 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDF33567.1 - 5.7e-41 140.0 0.0 9e-41 139.4 0.0 1.3 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 CDF33567.1 - 9.9e-05 22.2 0.1 0.0073 16.1 0.2 2.8 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF33567.1 - 0.0013 18.8 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 CDF33567.1 - 0.0029 17.1 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein AAA_11 PF13086.6 CDF33567.1 - 0.011 15.5 0.0 1 9.1 0.0 3.0 2 1 1 3 3 3 0 AAA domain T2SSE PF00437.20 CDF33567.1 - 0.053 12.6 0.0 0.092 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein HBB PF06777.11 CDF33567.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Helical and beta-bridge domain Steroid_dh PF02544.16 CDF33568.1 - 1.2e-33 116.2 0.9 1.8e-33 115.7 0.9 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CDF33568.1 - 0.0025 18.2 0.6 0.0066 16.8 0.6 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 CDF33568.1 - 0.0025 17.4 0.9 0.0037 16.8 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Mlo PF03094.15 CDF33569.1 - 0.002 16.6 28.9 0.0022 16.4 3.0 3.2 3 0 0 3 3 3 3 Mlo family Methyltransf_11 PF08241.12 CDF33571.1 - 1.7e-08 35.0 0.0 3.3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF33571.1 - 1.6e-07 31.9 0.0 3.7e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF33571.1 - 4.5e-07 29.9 0.0 6.9e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF33571.1 - 0.0025 17.6 0.0 0.034 13.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF33571.1 - 0.0038 17.9 0.0 0.0069 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain BRCT PF00533.26 CDF33571.1 - 0.027 14.8 0.0 0.056 13.8 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Nucleotid_trans PF03407.16 CDF33573.1 - 1.2e-18 67.9 0.0 1.8e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase MFS_2 PF13347.6 CDF33574.1 - 4.2e-06 25.6 9.6 4.2e-06 25.6 9.6 2.2 2 0 0 2 2 2 1 MFS/sugar transport protein Pkinase PF00069.25 CDF33575.1 - 1.1e-75 254.4 0.0 1.7e-75 253.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33575.1 - 2.1e-39 135.4 0.0 3.1e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF33575.1 - 9.7e-10 38.2 0.0 5.6e-09 35.7 0.0 2.0 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 CDF33575.1 - 6.9e-05 22.9 0.0 0.00028 20.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF33575.1 - 0.00034 20.0 0.1 0.0011 18.4 0.1 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDF33575.1 - 0.0011 18.6 0.1 0.0024 17.5 0.1 1.5 1 0 0 1 1 1 1 RIO1 family DUF3984 PF13136.6 CDF33575.1 - 0.0091 15.4 3.4 0.013 14.9 3.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) Choline_kinase PF01633.20 CDF33575.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 CDF33575.1 - 0.026 13.5 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 CDF33575.1 - 0.12 11.4 0.5 0.21 10.6 0.1 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 FTA2 PF13095.6 CDF33575.1 - 0.15 11.7 0.1 0.9 9.1 0.0 2.2 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Yip1 PF04893.17 CDF33576.1 - 2.3e-05 24.2 16.8 3.3e-05 23.7 16.8 1.3 1 0 0 1 1 1 1 Yip1 domain TraP PF07296.11 CDF33576.1 - 2.5 7.2 3.9 0.74 9.0 0.3 1.9 2 0 0 2 2 2 0 TraP protein Proteasome PF00227.26 CDF33577.1 - 1.8e-48 164.6 0.4 2.2e-48 164.3 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_M20 PF01546.28 CDF33579.1 - 1.6e-17 63.9 0.8 2.9e-17 63.1 0.8 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDF33579.1 - 5e-05 23.2 0.1 9.9e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Ion_trans_2 PF07885.16 CDF33582.1 - 1.4e-17 63.4 5.0 4.1e-17 61.9 5.0 1.8 1 0 0 1 1 1 1 Ion channel BK_channel_a PF03493.18 CDF33582.1 - 3.6e-09 36.7 0.0 7.6e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 CDF33582.1 - 3.7e-07 29.6 18.0 6.1e-07 28.9 18.0 1.2 1 0 0 1 1 1 1 Ion transport protein TrkA_N PF02254.18 CDF33582.1 - 0.15 12.3 0.0 2 8.7 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain Enolase_C PF00113.22 CDF33583.1 - 5.2e-138 459.3 0.1 7.3e-138 458.8 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CDF33583.1 - 3.9e-41 140.3 0.1 7.5e-41 139.4 0.1 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CDF33583.1 - 3.1e-10 40.0 0.0 1.8e-09 37.5 0.0 2.0 1 1 1 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDF33583.1 - 0.011 14.9 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus DUF3500 PF12006.8 CDF33583.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) NSP10 PF09401.10 CDF33584.1 - 0.053 13.6 0.1 0.066 13.3 0.1 1.3 1 1 0 1 1 1 0 RNA synthesis protein NSP10 Ribosomal_L22 PF00237.19 CDF33585.1 - 1.6e-35 121.4 0.1 2e-35 121.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Zot PF05707.12 CDF33585.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) tRNA_int_end_N2 PF12928.7 CDF33586.1 - 3.7e-17 62.3 0.0 1e-16 60.9 0.0 1.8 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Malate_DH PF12434.8 CDF33586.1 - 0.02 14.9 2.4 0.049 13.7 2.4 1.6 1 0 0 1 1 1 0 Malate dehydrogenase enzyme tRNA_int_endo_N PF02778.14 CDF33586.1 - 0.027 14.1 0.0 0.058 13.1 0.0 1.6 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain UQ_con PF00179.26 CDF33587.1 - 5.8e-53 178.3 0.0 6.6e-53 178.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF33587.1 - 0.0071 16.1 0.0 0.0087 15.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDF33587.1 - 0.012 15.9 0.1 0.014 15.7 0.1 1.4 1 1 0 1 1 1 0 RWD domain RVT_1 PF00078.27 CDF33588.1 - 1.2e-05 25.0 0.0 1.4e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PIF1 PF05970.14 CDF33589.1 - 4.3e-87 292.6 0.0 4.5e-52 177.4 0.0 2.4 2 1 1 3 3 3 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF33589.1 - 4.7e-58 196.6 0.1 1.2e-57 195.2 0.1 1.7 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF33589.1 - 1.8e-11 44.1 0.0 4e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF33589.1 - 0.038 14.3 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AMNp_N PF10423.9 CDF33589.1 - 0.053 13.2 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF33589.1 - 0.19 9.6 0.0 0.34 8.8 0.0 1.3 1 0 0 1 1 1 0 Helicase PHD PF00628.29 CDF33590.1 - 5.9e-09 35.7 32.3 1.9e-07 30.8 8.9 3.6 4 0 0 4 4 4 2 PHD-finger zf-4CXXC_R1 PF10497.9 CDF33590.1 - 0.00024 21.3 4.1 0.00024 21.3 4.1 3.7 2 1 1 3 3 3 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Trp_Tyr_perm PF03222.13 CDF33591.1 - 4.5e-49 167.5 17.9 1.1e-32 113.5 8.2 2.0 1 1 1 2 2 2 2 Tryptophan/tyrosine permease family TAF4 PF05236.14 CDF33593.1 - 3.8e-16 59.7 11.9 3.8e-16 59.7 11.9 3.7 4 1 0 4 4 4 1 Transcription initiation factor TFIID component TAF4 family IBN_N PF03810.19 CDF33593.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Importin-beta N-terminal domain DUF2828 PF11443.8 CDF33593.1 - 1.6 6.7 7.6 3 5.8 7.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PPL5 PF18168.1 CDF33593.1 - 4.7 6.4 6.1 12 5.1 6.1 1.6 1 0 0 1 1 1 0 Prim-pol family 5 SAGA-Tad1 PF12767.7 CDF33593.1 - 4.7 6.9 14.3 0.025 14.3 1.1 3.1 3 1 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit IBN_N PF03810.19 CDF33594.1 - 0.0095 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain TTSSLRR PF12468.8 CDF33594.1 - 0.048 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein DUF4290 PF14123.6 CDF33594.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) IRF-3 PF10401.9 CDF33595.1 - 0.057 13.2 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Interferon-regulatory factor 3 Lycopene_cycl PF05834.12 CDF33596.1 - 1e-72 245.4 0.2 5.3e-72 243.0 0.2 1.8 1 1 0 1 1 1 1 Lycopene cyclase protein p450 PF00067.22 CDF33597.1 - 1.8e-87 294.1 0.0 2.1e-87 293.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M13_N PF05649.13 CDF33599.1 - 1.6e-82 278.3 0.0 2.3e-82 277.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CDF33599.1 - 3.4e-60 203.1 0.0 1.2e-59 201.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M13 G-patch PF01585.23 CDF33600.1 - 1.5e-15 56.8 4.4 4.2e-15 55.4 4.4 1.9 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDF33600.1 - 5.8e-07 29.5 4.5 5.8e-07 29.5 4.5 3.4 3 0 0 3 3 3 1 G-patch domain G-patch PF01585.23 CDF33603.1 - 1.7e-16 59.8 3.2 4.2e-16 58.6 3.2 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDF33603.1 - 4.1e-08 33.2 2.4 1.6e-07 31.3 2.4 2.0 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 CDF33603.1 - 8.5e-05 22.5 0.0 0.0002 21.3 0.0 1.5 1 0 0 1 1 1 1 R3H domain PAM2 PF07145.15 CDF33603.1 - 0.047 13.4 0.8 0.14 11.9 0.8 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region zf-RING_2 PF13639.6 CDF33605.1 - 6.9e-12 45.5 8.6 7.2e-12 45.4 6.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDF33605.1 - 6.8e-09 35.3 3.5 2e-08 33.8 3.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF33605.1 - 3.1e-07 30.1 5.1 3.1e-07 30.1 5.1 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF33605.1 - 3.6e-07 30.4 3.8 1.1e-06 28.8 3.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDF33605.1 - 3.6e-06 26.8 5.7 3.6e-06 26.8 5.7 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF33605.1 - 1.5e-05 24.9 7.7 1.5e-05 24.9 7.7 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDF33605.1 - 5.2e-05 22.8 5.0 5.2e-05 22.8 5.0 1.9 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CDF33605.1 - 0.00098 19.1 8.1 0.046 13.8 7.4 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDF33605.1 - 0.0019 18.0 6.7 0.0052 16.6 6.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDF33605.1 - 0.0051 16.8 2.3 0.012 15.6 1.5 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CDF33605.1 - 0.028 14.3 7.7 0.064 13.1 7.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDF33605.1 - 0.036 14.2 5.9 1.1 9.5 4.0 3.2 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3H2C3 PF17122.5 CDF33605.1 - 0.069 13.2 1.9 0.25 11.4 1.9 2.0 1 0 0 1 1 1 0 Zinc-finger EGF_Tenascin PF18720.1 CDF33605.1 - 0.24 11.5 3.8 0.94 9.6 3.8 2.1 1 0 0 1 1 1 0 Tenascin EGF domain RINGv PF12906.7 CDF33605.1 - 0.25 11.5 6.2 0.71 10.0 6.2 1.8 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 CDF33605.1 - 0.28 11.4 7.3 0.24 11.6 5.3 2.1 2 0 0 2 2 1 0 FANCL C-terminal domain PHD PF00628.29 CDF33605.1 - 0.31 11.0 8.9 0.97 9.4 8.9 1.9 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 CDF33605.1 - 0.71 9.9 6.9 0.28 11.2 2.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 PSII_BNR PF14870.6 CDF33608.1 - 2e-82 276.8 1.0 2.3e-82 276.7 1.0 1.0 1 0 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 CDF33608.1 - 2.7e-06 26.4 0.0 0.016 14.1 0.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 CDF33608.1 - 0.00095 18.8 4.3 0.51 10.5 0.1 4.2 5 0 0 5 5 5 1 BNR/Asp-box repeat DUF4185 PF13810.6 CDF33608.1 - 0.032 13.5 0.2 2.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4185) BNR_6 PF15899.5 CDF33608.1 - 0.036 14.1 2.6 0.14 12.3 0.2 2.9 3 0 0 3 3 3 0 BNR-Asp box repeat Bac_luciferase PF00296.20 CDF33608.1 - 0.062 12.7 0.0 0.079 12.4 0.0 1.2 1 0 0 1 1 1 0 Luciferase-like monooxygenase SOR_SNZ PF01680.17 CDF33610.1 - 3.5e-100 334.0 4.1 4.7e-100 333.6 4.1 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 CDF33610.1 - 1.1e-07 31.4 3.9 4.1e-06 26.3 0.1 2.8 2 1 2 4 4 4 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 CDF33610.1 - 0.00042 19.5 0.4 0.23 10.5 0.0 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) NanE PF04131.14 CDF33610.1 - 0.0056 15.9 0.5 0.062 12.5 0.0 2.7 2 1 2 4 4 4 1 Putative N-acetylmannosamine-6-phosphate epimerase NMO PF03060.15 CDF33610.1 - 0.0088 15.5 1.2 0.3 10.4 0.1 2.3 2 0 0 2 2 2 1 Nitronate monooxygenase IGPS PF00218.21 CDF33610.1 - 0.0091 15.2 0.1 0.067 12.3 0.0 2.3 2 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 CDF33610.1 - 0.01 15.3 0.2 0.19 11.2 0.0 2.4 2 1 0 2 2 2 0 Histidine biosynthesis protein IMPDH PF00478.25 CDF33610.1 - 0.047 12.7 0.3 0.16 11.0 0.0 1.7 1 1 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain ThiI PF02568.14 CDF33610.1 - 0.12 11.9 0.1 0.31 10.6 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) PsbP PF01789.16 CDF33612.1 - 1.8e-08 34.7 0.0 2e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 PsbP Lpp-LpqN PF10738.9 CDF33612.1 - 0.13 11.8 0.0 4 6.9 0.0 2.0 1 1 1 2 2 2 0 Probable lipoprotein LpqN BING4CT PF08149.11 CDF33613.1 - 2.8e-26 91.1 0.0 1e-25 89.3 0.0 2.0 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 CDF33613.1 - 9e-06 26.3 0.2 0.00033 21.4 0.0 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat PUB PF09409.10 CDF33615.1 - 6.8e-19 67.6 0.0 1.8e-18 66.3 0.0 1.7 2 0 0 2 2 2 1 PUB domain Thioredoxin PF00085.20 CDF33615.1 - 1.3e-17 63.6 0.0 3e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin ubiquitin PF00240.23 CDF33615.1 - 1.7e-16 59.7 0.0 2.9e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDF33615.1 - 1e-05 25.2 0.0 2.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Thioredoxin_7 PF13899.6 CDF33615.1 - 0.022 14.9 0.6 0.26 11.5 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_9 PF14595.6 CDF33615.1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin STI1 PF17830.1 CDF33615.1 - 6.8 6.7 9.5 59 3.7 5.7 2.8 1 1 1 2 2 2 0 STI1 domain Rit1_C PF17184.4 CDF33617.1 - 1.8e-18 67.0 0.0 2.4e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Rit1 N-terminal domain ATG16 PF08614.11 CDF33618.1 - 0.0014 18.9 16.9 0.0014 18.9 16.9 4.2 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) PI3K_P85_iSH2 PF16454.5 CDF33618.1 - 0.014 15.0 5.5 0.014 15.0 5.5 4.5 3 1 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GAS PF13851.6 CDF33618.1 - 0.14 11.5 46.9 0.017 14.5 9.5 4.4 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 CDF33618.1 - 0.57 9.4 45.5 0.062 12.6 5.4 5.0 3 1 2 5 5 5 0 Protein of unknown function (DUF3450) HAP1_N PF04849.13 CDF33618.1 - 6 6.0 47.3 0.098 11.8 9.3 3.2 3 0 0 3 3 3 0 HAP1 N-terminal conserved region Fez1 PF06818.15 CDF33618.1 - 9.9 6.6 50.1 1.6 9.1 9.2 4.1 1 1 2 3 3 3 0 Fez1 An_peroxidase PF03098.15 CDF33619.1 - 1.3e-140 469.6 0.0 1.4e-140 469.4 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Ribosomal_L2_C PF03947.18 CDF33621.1 - 7.1e-48 162.0 4.1 1.2e-47 161.3 4.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CDF33621.1 - 4.6e-16 58.5 0.3 1.5e-15 56.9 0.1 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Proteasome PF00227.26 CDF33622.1 - 3.3e-57 193.1 0.1 4e-57 192.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF33622.1 - 5.3e-14 51.6 0.1 1.1e-13 50.6 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Sel1 PF08238.12 CDF33623.1 - 4.7e-86 281.3 80.2 2.5e-06 28.0 0.0 24.9 23 2 2 25 25 25 21 Sel1 repeat TPR_6 PF13174.6 CDF33623.1 - 0.0029 18.2 39.4 2.3 9.0 0.1 14.0 17 0 0 17 17 17 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF33623.1 - 0.0083 16.1 43.9 2.2 8.5 0.0 13.2 15 1 1 16 16 16 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33623.1 - 0.091 13.3 47.2 2.5 8.7 0.1 12.5 16 0 0 16 16 16 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33623.1 - 0.57 10.9 57.2 0.27 11.9 5.4 11.3 11 2 2 13 13 13 0 Tetratricopeptide repeat Tai4 PF16695.5 CDF33623.1 - 2 9.0 5.6 21 5.7 0.0 4.6 4 2 0 4 4 4 0 Type VI secretion system (T6SS), amidase immunity protein SpoIIE PF07228.12 CDF33626.1 - 4.9e-09 36.4 0.0 7.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CDF33626.1 - 0.00024 20.9 0.0 0.062 12.9 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDF33626.1 - 0.037 13.6 0.1 0.075 12.7 0.1 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C FA_desaturase PF00487.24 CDF33627.1 - 8.8e-33 114.2 6.9 8.8e-33 114.2 6.9 2.4 2 1 1 3 3 3 1 Fatty acid desaturase Cyt-b5 PF00173.28 CDF33627.1 - 9e-22 77.0 0.0 4.9e-21 74.7 0.0 2.3 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_hydro_129 PF11308.8 CDF33627.1 - 0.028 13.6 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases related to GH101 family, GH129 Coprogen_oxidas PF01218.18 CDF33628.1 - 8e-16 57.6 0.0 7.4e-15 54.4 0.0 2.0 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase PPR_2 PF13041.6 CDF33629.1 - 8.2e-83 272.4 16.7 1e-14 54.4 0.0 11.3 2 2 9 11 11 11 11 PPR repeat family PPR_1 PF12854.7 CDF33629.1 - 8.6e-71 233.3 10.6 6.5e-09 35.3 0.0 12.5 12 1 0 12 12 12 10 PPR repeat PPR_3 PF13812.6 CDF33629.1 - 5e-66 218.7 0.0 1.9e-15 56.6 0.0 7.7 3 3 3 7 7 7 7 Pentatricopeptide repeat domain PPR PF01535.20 CDF33629.1 - 3.1e-61 199.4 15.5 2.4e-07 30.5 0.0 13.9 14 0 0 14 14 14 9 PPR repeat PPR_long PF17177.4 CDF33629.1 - 3.9e-40 137.5 0.1 1.1e-11 44.5 0.0 5.0 3 1 2 5 5 5 4 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 CDF33629.1 - 8.9e-05 21.5 0.0 0.013 14.4 0.0 2.6 2 1 0 2 2 2 1 Mitochondrial 28S ribosomal protein S27 ECSIT PF06239.11 CDF33629.1 - 0.00014 21.0 0.2 5.6 6.0 0.0 5.1 4 2 2 7 7 7 2 Evolutionarily conserved signalling intermediate in Toll pathway TPR_14 PF13428.6 CDF33629.1 - 0.17 12.8 6.8 7.5 7.7 0.0 6.3 10 0 0 10 10 10 0 Tetratricopeptide repeat FA_desaturase PF00487.24 CDF33630.1 - 1.6e-24 87.1 13.1 2.1e-24 86.7 13.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase PIF1 PF05970.14 CDF33632.1 - 1e-61 209.2 0.0 1.2e-61 208.9 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase Herpes_Helicase PF02689.14 CDF33632.1 - 0.0094 13.9 0.0 0.013 13.4 0.0 1.1 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.6 CDF33632.1 - 0.025 14.4 0.1 0.078 12.8 0.1 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CDF33632.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain EMC3_TMCO1 PF01956.16 CDF33635.1 - 3.8e-06 26.7 0.7 5.3e-06 26.3 0.2 1.4 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like Helitron_like_N PF14214.6 CDF33636.1 - 1.1e-05 25.7 0.1 2.4e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus Sel1 PF08238.12 CDF33637.1 - 1e-17 64.2 9.2 0.00011 22.8 0.0 6.2 6 0 0 6 6 6 3 Sel1 repeat TIR_2 PF13676.6 CDF33637.1 - 9.9e-13 48.7 0.0 2.7e-12 47.3 0.0 1.8 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF33637.1 - 1.6e-06 28.0 0.0 2.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 TIR domain Roc PF08477.13 CDF33637.1 - 8.1e-05 22.8 0.0 0.002 18.4 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TPR_2 PF07719.17 CDF33637.1 - 0.01 15.9 0.8 8.4 6.8 0.1 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TIR-like PF10137.9 CDF33637.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain TPR_6 PF13174.6 CDF33637.1 - 0.27 11.9 3.1 6.6 7.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33637.1 - 0.3 11.8 12.0 0.96 10.2 2.5 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33637.1 - 0.38 11.7 7.3 0.79 10.7 0.3 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33637.1 - 0.82 10.2 7.7 34 5.0 0.1 3.8 2 1 0 3 3 3 0 Tetratricopeptide repeat DUF5613 PF18467.1 CDF33638.1 - 0.075 13.5 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5613) Chromo PF00385.24 CDF33642.1 - 0.00047 20.0 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF4542 PF15075.6 CDF33642.1 - 0.052 13.9 0.2 0.091 13.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4542) APH PF01636.23 CDF33645.1 - 1e-08 35.4 0.4 1.8e-08 34.6 0.4 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Sel1 PF08238.12 CDF33647.1 - 4.5e-30 103.4 3.9 0.00012 22.6 0.0 6.8 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.6 CDF33647.1 - 1.4e-09 38.0 7.0 0.033 14.8 0.1 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33647.1 - 8.3e-08 32.8 5.0 1 10.1 0.4 5.5 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF33647.1 - 7.7e-07 29.1 0.1 9.5 6.9 0.0 6.7 6 1 1 7 7 7 1 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF33647.1 - 9e-05 22.7 1.2 1.6 9.0 0.1 4.3 2 2 2 4 4 4 1 Arginine decarboxylase helical bundle domain TPR_11 PF13414.6 CDF33647.1 - 0.00091 18.9 2.1 7.3 6.4 0.0 5.5 6 0 0 6 6 6 1 TPR repeat ComR_TPR PF18710.1 CDF33647.1 - 0.026 14.1 0.0 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 ComR tetratricopeptide TPR_7 PF13176.6 CDF33647.1 - 0.91 9.7 13.0 13 6.1 0.2 6.1 7 2 1 8 8 8 0 Tetratricopeptide repeat APH PF01636.23 CDF33649.1 - 8.4e-05 22.6 0.0 0.00011 22.2 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF33649.1 - 0.1 12.2 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fasciclin PF02469.22 CDF33650.1 - 4.3e-54 182.2 0.0 8.4e-13 48.7 0.0 6.7 4 4 0 4 4 4 4 Fasciclin domain Hint PF01079.20 CDF33650.1 - 3.6e-24 85.5 0.0 6.8e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Hint module DUF3035 PF11233.8 CDF33650.1 - 0.037 14.3 0.2 0.3 11.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3035) PT-HINT PF07591.11 CDF33650.1 - 0.085 13.1 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Pretoxin HINT domain PRCC PF10253.9 CDF33653.1 - 0.018 15.9 0.9 0.027 15.3 0.9 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Med3 PF11593.8 CDF33653.1 - 1.3 8.2 13.9 1.8 7.7 13.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal P33MONOX PF15302.6 CDF33660.1 - 1.3 8.7 4.5 1.7 8.3 4.5 1.1 1 0 0 1 1 1 0 P33 mono-oxygenase Oest_recep PF02159.15 CDF33661.1 - 0.18 12.3 1.1 0.2 12.1 1.1 1.0 1 0 0 1 1 1 0 Oestrogen receptor WD40 PF00400.32 CDF33666.1 - 0.00067 20.4 3.5 0.0007 20.4 2.0 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat NdhS PF11623.8 CDF33666.1 - 0.065 12.9 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S RF-1 PF00472.20 CDF33669.1 - 4.9e-34 116.7 0.5 9.1e-34 115.9 0.5 1.4 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.18 CDF33669.1 - 2e-33 115.9 0.0 3.8e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 PCRF domain DUF1818 PF08848.11 CDF33670.1 - 7.3e-15 55.0 0.0 5.2e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1818) DEC-1_N PF04625.13 CDF33670.1 - 0.02 14.0 4.0 0.027 13.5 4.0 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ephrin_rec_like PF07699.13 CDF33671.1 - 2.4e-47 158.4 107.2 1e-09 38.0 12.8 9.3 1 1 8 9 9 9 9 Putative ephrin-receptor like VSP PF03302.13 CDF33671.1 - 0.0078 15.1 66.5 0.54 9.1 5.2 4.5 1 1 2 4 4 4 4 Giardia variant-specific surface protein TNFR_c6 PF00020.18 CDF33671.1 - 1.3 9.5 77.1 0.75 10.3 0.7 10.1 1 1 11 13 13 13 0 TNFR/NGFR cysteine-rich region WD40 PF00400.32 CDF33672.1 - 1.4e-10 41.5 0.9 0.056 14.3 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33672.1 - 1e-06 29.0 0.6 0.087 13.1 0.0 4.0 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF33672.1 - 0.00057 18.7 0.5 4.9 5.7 0.0 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 CDF33672.1 - 0.034 13.7 1.3 0.097 12.2 1.1 1.7 1 1 0 1 1 1 0 PQQ-like domain YchF-GTPase_C PF06071.13 CDF33672.1 - 0.047 13.9 0.3 3.4 7.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF933) VIGSSK PF14773.6 CDF33676.1 - 0.019 15.1 0.0 0.023 14.8 0.0 1.1 1 0 0 1 1 1 0 Helicase-associated putative binding domain, C-terminal GATase_7 PF13537.6 CDF33677.1 - 8e-22 77.4 0.0 1.3e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDF33677.1 - 2.6e-20 73.0 0.1 4.1e-20 72.3 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 CDF33677.1 - 1.9e-08 34.0 0.1 3.7e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 CDF33677.1 - 5.7e-06 25.4 0.0 1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 CDF33677.1 - 0.0021 16.9 0.0 0.38 9.4 0.0 2.4 2 1 0 2 2 2 2 Glutamine amidotransferases class-II zf-C3HC4_3 PF13920.6 CDF33678.1 - 5.5e-11 42.1 17.3 9.2e-11 41.4 17.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF33678.1 - 0.0011 18.8 16.1 0.0019 18.0 16.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 TmoB PF06234.12 CDF33678.1 - 0.037 14.1 0.4 7.1 6.8 0.0 3.0 3 0 0 3 3 3 0 Toluene-4-monooxygenase system protein B (TmoB) TPR_2 PF07719.17 CDF33679.1 - 3.6e-17 61.0 1.2 0.0064 16.5 0.0 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDF33679.1 - 1.3e-16 59.7 0.0 0.0029 17.4 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDF33679.1 - 1.6e-12 46.5 0.1 0.046 13.9 0.0 5.9 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33679.1 - 4.5e-11 43.2 12.9 1.6e-07 31.8 0.7 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF33679.1 - 3.5e-10 39.5 0.1 0.032 14.6 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF33679.1 - 3.7e-10 40.0 6.4 0.0031 17.8 0.0 5.3 4 2 1 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDF33679.1 - 4.5e-10 39.0 0.1 0.0048 16.6 0.0 4.8 4 2 2 6 6 6 2 TPR repeat TPR_7 PF13176.6 CDF33679.1 - 7e-08 32.0 2.9 0.0098 15.9 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33679.1 - 1.4e-07 31.7 17.8 0.00033 21.2 0.1 7.0 4 2 4 8 8 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33679.1 - 4.3e-05 23.9 6.0 0.21 12.1 0.1 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDF33679.1 - 0.00027 21.0 7.8 0.0076 16.4 0.1 4.2 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDF33679.1 - 0.0038 17.0 12.8 0.088 12.7 0.0 5.4 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF33679.1 - 0.006 17.1 1.4 20 6.1 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 CDF33679.1 - 0.062 13.6 0.1 0.062 13.6 0.1 3.9 3 1 1 4 4 3 0 Tetratricopeptide repeat DDHD PF02862.17 CDF33679.1 - 0.062 13.5 5.7 0.1 12.8 5.7 1.4 1 0 0 1 1 1 0 DDHD domain EPL1 PF10513.9 CDF33679.1 - 0.086 13.2 7.6 0.14 12.5 7.6 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like TERB2 PF15101.6 CDF33679.1 - 0.11 12.5 13.1 0.18 11.9 13.1 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Strabismus PF06638.11 CDF33679.1 - 0.11 11.1 4.2 0.16 10.6 4.2 1.2 1 0 0 1 1 1 0 Strabismus protein Band_3_cyto PF07565.13 CDF33679.1 - 0.17 11.6 4.1 0.23 11.2 4.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDF33679.1 - 0.23 10.2 8.0 0.28 9.9 8.0 1.2 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 CDF33679.1 - 0.63 8.8 7.1 0.85 8.3 7.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF702 PF05142.12 CDF33679.1 - 0.75 10.3 8.0 1.5 9.3 8.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) DUF2722 PF10846.8 CDF33679.1 - 0.86 8.5 26.3 1.2 8.0 26.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Ndc1_Nup PF09531.10 CDF33679.1 - 0.91 8.1 4.4 1.1 7.9 4.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4647 PF15504.6 CDF33679.1 - 0.92 8.5 13.6 1.2 8.2 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Rxt3 PF08642.10 CDF33679.1 - 0.97 10.2 4.0 26 5.6 4.9 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 SLC12 PF03522.15 CDF33679.1 - 1 8.3 7.0 1.3 7.9 7.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 CDF33679.1 - 1.1 8.9 9.6 2.5 7.8 9.6 1.6 1 0 0 1 1 1 0 FAM176 family MDM10 PF12519.8 CDF33679.1 - 1.4 7.7 5.4 1.7 7.4 5.4 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SpoIIP PF07454.11 CDF33679.1 - 1.5 8.2 11.0 2.3 7.6 11.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4770 PF15994.5 CDF33679.1 - 1.6 8.9 9.8 2.9 8.1 9.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) MMR1 PF08505.10 CDF33679.1 - 1.9 8.7 12.5 3.1 8.0 12.5 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pex14_N PF04695.13 CDF33679.1 - 2.4 8.8 14.7 5.2 7.7 14.7 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4746 PF15928.5 CDF33679.1 - 4.4 6.6 7.1 5.6 6.3 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Med15 PF09606.10 CDF33679.1 - 5.5 5.6 23.1 7.6 5.1 23.1 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.16 CDF33679.1 - 6.7 6.7 6.8 12 5.9 6.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4820 PF16091.5 CDF33679.1 - 6.9 6.0 9.0 12 5.2 9.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TFIIA PF03153.13 CDF33679.1 - 7.1 6.5 32.9 3.8 7.4 31.1 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spore_coat_CotO PF14153.6 CDF33679.1 - 8.7 6.2 18.9 15 5.4 18.9 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Spt20 PF12090.8 CDF33679.1 - 9.2 5.8 38.1 17 4.9 38.1 1.4 1 0 0 1 1 1 0 Spt20 family AA_kinase PF00696.28 CDF33680.1 - 6.1e-41 140.6 0.2 9.9e-41 139.9 0.2 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 CDF33680.1 - 9.9e-09 34.9 3.1 0.003 17.3 0.2 2.7 3 0 0 3 3 3 2 ACT domain ACT PF01842.25 CDF33680.1 - 1.3e-07 31.2 0.8 0.0017 18.0 0.0 2.5 2 0 0 2 2 2 2 ACT domain ImmE5 PF11480.8 CDF33681.1 - 0.064 13.7 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 2 0 Colicin-E5 Imm protein ELYS-bb PF16687.5 CDF33686.1 - 0.0074 15.0 0.0 0.0086 14.7 0.0 1.0 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin DNA_RNApol_7kD PF03604.13 CDF33686.1 - 0.092 12.4 0.2 0.24 11.1 0.2 1.7 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit XAF1_C PF18608.1 CDF33687.1 - 0.015 14.8 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain Sina PF03145.16 CDF33689.1 - 1.6 8.7 2.5 2 8.3 2.5 1.1 1 0 0 1 1 1 0 Seven in absentia protein family PAN_1 PF00024.26 CDF33690.1 - 0.014 15.3 0.2 0.016 15.2 0.2 1.1 1 0 0 1 1 1 0 PAN domain ACPS PF01648.20 CDF33693.1 - 0.062 13.4 0.2 0.062 13.4 0.2 1.2 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase superfamily RVT_3 PF13456.6 CDF33697.1 - 0.042 13.7 0.2 0.072 12.9 0.2 1.6 1 1 0 1 1 1 0 Reverse transcriptase-like WD40 PF00400.32 CDF33698.1 - 3.3e-13 49.9 8.4 0.01 16.6 0.2 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33698.1 - 6.9e-05 23.1 0.0 0.51 10.7 0.0 3.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDF33698.1 - 0.085 12.8 0.5 22 5.1 0.1 3.0 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF2957 PF11170.8 CDF33698.1 - 0.11 11.4 0.0 1.3 7.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2957) Pkinase PF00069.25 CDF33702.1 - 1.1e-61 208.6 0.0 2.1e-61 207.6 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33702.1 - 7.6e-31 107.3 0.0 1.3e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF33702.1 - 0.00015 20.8 0.1 0.00023 20.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF33702.1 - 0.036 14.0 0.2 0.16 11.8 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family HEAT_2 PF13646.6 CDF33702.1 - 0.23 11.9 0.5 19 5.7 0.1 3.0 4 0 0 4 4 4 0 HEAT repeats Syja_N PF02383.18 CDF33705.1 - 4.3e-62 210.3 0.0 6.2e-62 209.8 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DHQ_synthase PF01761.20 CDF33706.1 - 4.1e-61 206.4 0.0 6.4e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 CDF33706.1 - 1.4e-09 38.1 0.0 1.9e-07 31.1 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 CDF33706.1 - 0.00017 20.5 0.0 0.00028 19.8 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase LacI PF00356.21 CDF33706.1 - 0.023 14.5 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family S10_plectin PF03501.15 CDF33708.1 - 1.5e-40 137.2 0.1 1.8e-40 136.9 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 CDF33708.1 - 0.078 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Desmo_N PF06771.11 CDF33708.1 - 0.1 13.0 0.1 0.14 12.5 0.1 1.2 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus RRM_1 PF00076.22 CDF33709.1 - 1.5e-14 53.6 0.0 1.8e-07 30.9 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF33709.1 - 0.021 14.9 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif HAD_2 PF13419.6 CDF33711.1 - 4.4e-25 88.8 0.0 5.1e-25 88.6 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF33711.1 - 2.6e-16 60.5 1.0 6.4e-15 56.0 1.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF33711.1 - 8.9e-06 26.2 0.0 1.7e-05 25.3 0.0 1.5 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF33711.1 - 0.027 14.5 0.2 0.17 12.0 0.0 2.3 2 1 1 3 3 3 0 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDF33711.1 - 0.04 14.0 0.0 0.25 11.5 0.0 2.3 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase Urocanase PF01175.18 CDF33711.1 - 0.078 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Urocanase Rossmann-like domain zf-CCCH PF00642.24 CDF33713.1 - 0.0065 16.3 1.6 0.0096 15.8 1.6 1.2 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TSSC4 PF15264.6 CDF33713.1 - 0.095 13.0 0.0 0.1 12.9 0.0 1.1 1 0 0 1 1 1 0 Tumour suppressing sub-chromosomal transferable candidate 4 Peptidase_S41 PF03572.18 CDF33714.1 - 5.4e-45 153.0 0.1 3.9e-44 150.1 0.0 2.2 2 0 0 2 2 2 1 Peptidase family S41 PDZ_6 PF17820.1 CDF33714.1 - 1.1e-09 38.0 0.1 4.1e-09 36.2 0.1 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CDF33714.1 - 8.2e-08 32.5 0.0 2.6e-07 30.9 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDF33714.1 - 8.3e-06 26.1 0.0 2.8e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 CDF33714.1 - 0.0016 18.4 0.0 0.0087 16.0 0.0 2.2 2 0 0 2 2 2 1 Tricorn protease PDZ domain Lambda_CIII PF02061.16 CDF33714.1 - 0.17 12.0 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Lambda Phage CIII PRK PF00485.18 CDF33717.1 - 5.6e-08 32.8 0.0 1.1e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.22 CDF33717.1 - 0.02 14.5 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Axin_b-cat_bind PF08833.10 CDF33717.1 - 3.9 7.7 5.3 0.41 10.8 0.3 1.9 2 0 0 2 2 2 0 Axin beta-catenin binding domain Amino_oxidase PF01593.24 CDF33719.1 - 2.5e-16 60.0 0.0 9.5e-16 58.1 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF33719.1 - 2.7e-09 37.1 0.1 7.1e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF33719.1 - 1.9e-05 24.5 0.0 0.01 15.4 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF33719.1 - 0.0006 19.1 0.6 0.18 11.0 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF33719.1 - 0.0012 17.7 0.0 0.38 9.4 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_9 PF13454.6 CDF33719.1 - 0.0047 16.9 0.1 1 9.4 0.0 2.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding RT_RNaseH PF17917.1 CDF33720.1 - 3.8e-22 78.6 0.0 7.4e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF33720.1 - 5.2e-21 74.5 0.0 1.1e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF33720.1 - 4.6e-06 26.3 0.0 1.2e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Rhomboid PF01694.22 CDF33721.1 - 3.6e-37 127.7 6.8 6.4e-37 126.9 6.8 1.4 1 0 0 1 1 1 1 Rhomboid family NAD_Gly3P_dh_C PF07479.14 CDF33721.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus DUF3326 PF11805.8 CDF33722.1 - 3e-135 450.5 3.6 3.5e-135 450.2 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3326) Peripla_BP_3 PF13377.6 CDF33722.1 - 0.071 13.4 0.1 0.56 10.5 0.0 2.3 1 1 1 2 2 2 0 Periplasmic binding protein-like domain MMR_HSR1 PF01926.23 CDF33723.1 - 1.7e-12 47.4 0.2 4.5e-10 39.6 0.1 2.6 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF33723.1 - 0.0013 18.6 0.1 0.0033 17.4 0.1 1.6 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 CDF33723.1 - 0.005 16.9 1.0 0.11 12.6 0.1 2.6 3 0 0 3 3 3 1 Dynamin family ATP_bind_1 PF03029.17 CDF33723.1 - 0.0078 16.0 0.1 4.6 7.0 0.0 2.3 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Roc PF08477.13 CDF33723.1 - 0.014 15.6 0.0 0.49 10.6 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 CDF33723.1 - 0.017 14.6 0.1 0.18 11.4 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B IIGP PF05049.13 CDF33723.1 - 0.026 13.6 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 CDF33723.1 - 0.037 13.6 0.0 4 6.9 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDF33723.1 - 0.2 12.0 0.1 0.42 11.0 0.1 1.5 2 0 0 2 2 2 0 AAA ATPase domain NOG1 PF06858.14 CDF33723.1 - 0.32 10.8 1.0 3.2 7.6 1.0 2.2 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Mob1_phocein PF03637.17 CDF33724.1 - 7.3e-67 224.6 0.1 8.7e-67 224.4 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family THDPS_N_2 PF14805.6 CDF33724.1 - 0.012 15.8 0.1 0.028 14.6 0.0 1.6 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal DDE_3 PF13358.6 CDF33725.1 - 1.2e-20 73.8 0.0 2.2e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF33725.1 - 9.2e-10 38.2 0.0 1.8e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF33725.1 - 1.3e-05 24.9 0.6 3e-05 23.7 0.6 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF33725.1 - 0.00086 19.9 3.6 0.53 10.9 0.3 2.7 1 1 1 2 2 2 2 Homeodomain-like domain HEPN_Swt1 PF18731.1 CDF33725.1 - 0.82 10.0 3.1 26 5.2 0.0 2.9 4 0 0 4 4 4 0 Swt1-like HEPN tRNA-synt_2 PF00152.20 CDF33726.1 - 1.4e-81 274.0 0.0 8.6e-81 271.4 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDF33726.1 - 7.2e-12 45.1 0.1 1.6e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDF33726.1 - 0.072 12.6 0.1 0.47 9.9 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) adh_short PF00106.25 CDF33729.1 - 9e-24 84.0 0.3 1e-22 80.6 0.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF33729.1 - 3.7e-12 46.3 0.8 2.1e-11 43.9 0.9 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF33729.1 - 2.1e-06 27.8 0.5 3.5e-06 27.0 0.5 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDF33729.1 - 0.00019 21.0 0.1 0.0015 18.0 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CDF33729.1 - 0.12 12.3 1.5 0.83 9.5 1.5 2.1 1 1 0 1 1 1 0 NAD(P)H-binding SafA PF17073.5 CDF33730.1 - 0.093 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Two-component-system connector protein Ipi1_N PF12333.8 CDF33732.1 - 0.0054 17.3 0.7 5.9 7.5 0.0 3.9 4 0 0 4 4 4 2 Rix1 complex component involved in 60S ribosome maturation CHORD PF04968.12 CDF33734.1 - 0.16 12.7 4.3 6.7 7.5 0.5 2.4 1 1 1 2 2 2 0 CHORD zf-C2H2 PF00096.26 CDF33734.1 - 0.42 11.2 3.9 4.1 8.0 0.1 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type MoCF_biosynth PF00994.24 CDF33737.1 - 6.6e-30 103.7 0.0 1.3e-29 102.7 0.0 1.5 1 0 0 1 1 1 1 Probable molybdopterin binding domain FAD_syn PF06574.12 CDF33737.1 - 0.0034 17.3 0.0 0.0056 16.6 0.0 1.4 1 0 0 1 1 1 1 FAD synthetase COX16 PF14138.6 CDF33738.1 - 3.9e-10 40.1 0.1 1.3e-09 38.4 0.1 1.7 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 V-SNARE_C PF12352.8 CDF33741.1 - 2.2e-09 37.5 0.2 7.6e-09 35.7 0.1 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus CDT1_C PF16679.5 CDF33741.1 - 0.072 13.5 0.9 0.14 12.6 0.3 1.7 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain TPR_MLP1_2 PF07926.12 CDF33741.1 - 0.08 13.0 0.0 0.52 10.4 0.0 1.9 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein zf-Di19 PF05605.12 CDF33742.1 - 3.8e-06 27.1 5.6 3.8e-06 27.1 5.6 2.5 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 CDF33742.1 - 0.00065 20.0 27.0 0.02 15.3 6.5 4.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF33742.1 - 0.00094 19.8 35.7 0.29 12.1 9.3 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 CDF33742.1 - 0.07 13.6 35.0 1.8 9.2 10.1 3.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-AN1 PF01428.16 CDF33742.1 - 1.7 8.9 22.1 0.87 9.8 10.6 3.3 1 1 2 3 3 3 0 AN1-like Zinc finger Actin_micro PF17003.5 CDF33742.1 - 1.9 7.6 15.1 0.085 12.0 0.5 2.7 1 1 1 2 2 2 0 Putative actin-like family HypA PF01155.19 CDF33742.1 - 2.6 8.1 8.8 6.4 6.8 8.8 1.7 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Translin PF01997.16 CDF33744.1 - 4e-49 167.4 0.0 4.7e-49 167.2 0.0 1.0 1 0 0 1 1 1 1 Translin family Topoisom_I PF01028.20 CDF33745.1 - 2.1e-96 321.7 0.3 4.2e-96 320.7 0.3 1.5 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 CDF33745.1 - 1.7e-87 292.4 0.1 1.7e-87 292.4 0.1 2.4 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 CDF33745.1 - 4e-34 116.4 0.5 1e-33 115.0 0.5 1.8 1 0 0 1 1 1 1 C-terminal topoisomerase domain IFT43 PF15305.6 CDF33745.1 - 0.67 10.1 5.4 0.13 12.4 0.6 2.3 2 0 0 2 2 2 0 Intraflagellar transport protein 43 TRM PF02005.16 CDF33747.1 - 3.7e-113 378.5 0.0 4.9e-113 378.1 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 CDF33747.1 - 0.0039 17.0 0.0 0.0063 16.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Rubredoxin_2 PF18073.1 CDF33747.1 - 0.5 10.1 1.8 0.55 10.0 0.3 1.9 2 0 0 2 2 2 0 Rubredoxin metal binding domain NUC173 PF08161.12 CDF33750.1 - 1.3e-27 96.8 0.0 5.8e-27 94.7 0.0 2.1 3 0 0 3 3 3 1 NUC173 domain HEAT PF02985.22 CDF33750.1 - 0.12 12.7 0.3 10 6.7 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat DUF4211 PF13926.6 CDF33751.1 - 0.0076 16.3 0.1 0.014 15.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) DNA_ligase_A_M PF01068.21 CDF33752.1 - 6.7e-29 101.0 0.1 1.2e-28 100.1 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CDF33752.1 - 8.2e-13 49.0 0.1 5.1e-12 46.5 0.0 2.4 3 0 0 3 3 3 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CDF33752.1 - 1.8e-09 38.1 0.1 6.2e-09 36.3 0.1 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 CDF33752.1 - 1.9e-09 37.8 0.5 3.1e-07 30.7 0.2 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CDF33752.1 - 6.2e-08 32.8 0.2 2.3e-05 24.6 0.0 2.8 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT PF00533.26 CDF33752.1 - 2.7e-05 24.5 1.0 0.038 14.4 0.4 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDF33752.1 - 0.0023 17.8 0.2 0.25 11.3 0.0 3.1 3 0 0 3 3 3 1 twin BRCT domain Ribosomal_L29e PF01779.17 CDF33753.1 - 3.9e-20 71.9 11.0 6.5e-20 71.2 11.0 1.4 1 0 0 1 1 1 1 Ribosomal L29e protein family ABM PF03992.16 CDF33755.1 - 0.0026 17.8 0.0 0.008 16.3 0.0 1.8 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase BATS PF06968.13 CDF33757.1 - 6.8e-20 71.0 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CDF33757.1 - 7.5e-15 55.7 0.1 1.1e-14 55.1 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Pro_isomerase PF00160.21 CDF33758.1 - 6.4e-46 156.5 0.0 7.4e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Spc7 PF08317.11 CDF33761.1 - 0.0066 15.4 18.0 0.0099 14.8 18.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein MscS_porin PF12795.7 CDF33761.1 - 0.013 15.1 14.1 0.021 14.4 14.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Jnk-SapK_ap_N PF09744.9 CDF33761.1 - 0.014 15.6 20.1 0.022 15.0 20.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Phage_HK97_TLTM PF06120.11 CDF33761.1 - 0.024 13.8 7.4 0.036 13.3 7.4 1.2 1 0 0 1 1 1 0 Tail length tape measure protein LPP PF04728.13 CDF33761.1 - 0.067 13.6 6.4 4.6 7.7 0.2 2.5 2 0 0 2 2 2 0 Lipoprotein leucine-zipper TF_AP-2 PF03299.14 CDF33761.1 - 0.073 13.0 4.3 0.12 12.4 4.3 1.2 1 0 0 1 1 1 0 Transcription factor AP-2 UPF0242 PF06785.11 CDF33761.1 - 0.23 11.5 13.7 0.42 10.7 13.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 CDF33761.1 - 0.45 9.5 13.1 0.73 8.9 13.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5082 PF16888.5 CDF33761.1 - 0.47 10.7 12.8 0.59 10.4 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Exonuc_VII_L PF02601.15 CDF33761.1 - 0.77 9.3 9.8 1.1 8.7 9.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2070 PF09843.9 CDF33761.1 - 0.82 7.9 6.6 1.3 7.3 6.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Vps51 PF08700.11 CDF33761.1 - 0.97 9.6 6.0 9.4 6.4 0.8 2.6 2 0 0 2 2 2 0 Vps51/Vps67 PEARLI-4 PF05278.12 CDF33761.1 - 1.1 8.7 12.4 2 7.9 12.4 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) HrpB7 PF09486.10 CDF33761.1 - 2.4 8.5 16.6 26 5.2 16.4 2.2 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Nup88 PF10168.9 CDF33761.1 - 2.5 5.8 14.5 3.3 5.4 14.5 1.1 1 0 0 1 1 1 0 Nuclear pore component ADIP PF11559.8 CDF33761.1 - 2.6 8.1 19.9 4.1 7.5 4.9 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TolA_bind_tri PF16331.5 CDF33761.1 - 3.2 7.9 15.4 3.3 7.9 2.5 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF4407 PF14362.6 CDF33761.1 - 3.7 6.8 11.8 7.5 5.8 11.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 CDF33761.1 - 4.5 7.7 23.2 6.4 7.2 23.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) MIG-14_Wnt-bd PF06664.12 CDF33761.1 - 4.8 6.3 19.4 1.5 8.0 6.6 3.1 1 1 2 3 3 3 0 Wnt-binding factor required for Wnt secretion FapA PF03961.13 CDF33761.1 - 8.4 4.9 12.4 6.6 5.2 8.1 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 CDF33761.1 - 9.2 6.8 11.8 15 6.0 1.9 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1995 PF09353.10 CDF33762.1 - 9.5e-47 159.6 0.0 1.3e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Acyltransf_C PF16076.5 CDF33763.1 - 3e-13 49.6 0.3 1e-12 47.9 0.0 2.0 2 0 0 2 2 2 1 Acyltransferase C-terminus Acyltransferase PF01553.21 CDF33763.1 - 2.5e-11 43.4 0.0 3.6e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase PGM_PMM_I PF02878.16 CDF33764.1 - 1.6e-30 105.7 0.1 2.5e-30 105.0 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDF33764.1 - 3.5e-27 94.8 0.0 7.8e-27 93.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDF33764.1 - 4.5e-12 46.5 0.0 1.1e-11 45.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDF33764.1 - 0.00013 22.0 0.0 0.00032 20.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Tsg PF04668.12 CDF33768.1 - 0.043 14.5 0.1 0.069 13.8 0.1 1.3 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region Abhydrolase_6 PF12697.7 CDF33771.1 - 0.00018 22.2 0.0 0.00089 19.9 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family DAGAT PF03982.13 CDF33771.1 - 0.00028 19.9 0.0 0.00047 19.2 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase AIG2_2 PF13772.6 CDF33771.1 - 0.001 19.4 0.0 0.004 17.5 0.0 1.9 2 0 0 2 2 2 1 AIG2-like family Thioesterase PF00975.20 CDF33771.1 - 0.23 11.5 0.0 0.45 10.6 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Sec23_trunk PF04811.15 CDF33774.1 - 1.3e-18 67.5 0.0 2e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CDF33774.1 - 1.7e-13 50.3 0.0 3.6e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDF33774.1 - 4.2e-07 29.9 5.9 8.7e-07 28.9 5.9 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Rad51 PF08423.11 CDF33776.1 - 7.7e-11 41.7 0.0 5.2e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 CDF33776.1 - 3.1e-06 26.9 1.7 1.8e-05 24.4 1.7 2.0 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CDF33776.1 - 0.00068 19.0 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 KaiC DnaB_C PF03796.15 CDF33776.1 - 0.0047 16.3 0.0 0.0073 15.7 0.0 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 CDF33776.1 - 0.007 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin IstB_IS21 PF01695.17 CDF33776.1 - 0.019 14.7 0.1 0.053 13.2 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein RecA PF00154.21 CDF33776.1 - 0.27 10.7 0.5 0.41 10.1 0.0 1.5 2 0 0 2 2 2 0 recA bacterial DNA recombination protein DprA_WH PF17782.1 CDF33776.1 - 0.45 10.7 11.1 1.9 8.6 1.9 2.7 2 0 0 2 2 2 0 DprA winged helix domain PMM PF03332.13 CDF33777.1 - 3.5e-106 353.9 0.4 4e-106 353.7 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 CDF33777.1 - 0.00016 21.5 0.0 0.002 17.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDF33777.1 - 0.00018 21.1 0.0 0.0066 16.0 0.0 2.0 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase DUF4630 PF15443.6 CDF33778.1 - 0.018 15.2 0.1 0.035 14.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4630) DUF3619 PF12279.8 CDF33778.1 - 0.14 12.5 1.0 0.33 11.3 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) FUSC PF04632.12 CDF33778.1 - 1.1 7.7 5.4 1.7 7.1 5.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family RabGAP-TBC PF00566.18 CDF33784.1 - 4.7e-44 150.6 0.0 7.2e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain eIF-6 PF01912.18 CDF33785.1 - 1.4e-76 256.3 1.2 2e-76 255.8 0.7 1.5 2 0 0 2 2 2 1 eIF-6 family SNF2_N PF00176.23 CDF33786.1 - 9.5e-66 221.9 0.1 1.7e-65 221.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF33786.1 - 1.1e-19 70.9 0.6 3e-19 69.4 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 CDF33786.1 - 4.3e-18 65.4 8.2 4.3e-18 65.4 8.2 3.2 2 0 0 2 2 2 1 HSA ResIII PF04851.15 CDF33786.1 - 1.8e-07 31.3 0.0 4.2e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CDF33786.1 - 0.018 14.2 0.1 0.075 12.2 0.0 1.9 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 DUF4135 PF13575.6 CDF33786.1 - 0.078 12.3 0.3 0.16 11.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Aquarius_N PF16399.5 CDF33787.1 - 1e-105 354.6 0.0 1.4e-105 354.2 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 CDF33787.1 - 2.6e-29 102.8 0.0 4.6e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CDF33787.1 - 4.6e-29 101.5 0.0 8.9e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF33787.1 - 9.5e-12 45.5 0.4 4.4e-11 43.3 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF33787.1 - 8.1e-09 35.5 0.1 0.00051 19.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CDF33787.1 - 6e-07 29.4 0.1 0.28 10.9 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 CDF33787.1 - 4e-05 23.3 0.1 9.1e-05 22.2 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 CDF33787.1 - 7.7e-05 22.4 0.1 0.00037 20.1 0.0 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 CDF33787.1 - 0.0016 18.9 0.0 0.0077 16.6 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 CDF33787.1 - 0.0059 15.9 0.0 0.0059 15.9 0.0 2.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CDF33787.1 - 0.009 16.3 0.0 0.041 14.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDF33787.1 - 0.016 15.6 0.0 0.041 14.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 CDF33787.1 - 0.05 13.6 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PhoH PF02562.16 CDF33787.1 - 0.051 13.0 0.1 0.21 11.0 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 CDF33787.1 - 0.052 12.6 0.1 0.1 11.6 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Helicase_RecD PF05127.14 CDF33787.1 - 0.07 13.0 0.0 7.8 6.3 0.0 2.4 2 0 0 2 2 2 0 Helicase Rad17 PF03215.15 CDF33787.1 - 0.082 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase PF06745.13 CDF33787.1 - 0.21 10.9 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 KaiC GCP_C_terminal PF04130.13 CDF33788.1 - 7.8e-22 78.1 1.8 5.3e-21 75.4 1.9 2.0 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CDF33788.1 - 0.001 18.8 1.6 0.0035 17.0 0.2 2.5 2 2 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF547 PF04784.14 CDF33789.1 - 5.2e-31 107.3 0.0 9e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DEP PF00610.21 CDF33789.1 - 6e-21 74.3 0.0 1.1e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Abhydrolase_6 PF12697.7 CDF33790.1 - 7e-18 66.0 1.9 1.2e-17 65.3 1.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family MR_MLE_C PF13378.6 CDF33790.1 - 3.9e-11 42.9 0.0 6.9e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like Abhydrolase_1 PF00561.20 CDF33790.1 - 2.1e-09 37.4 0.1 5.6e-09 36.0 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF33790.1 - 1e-08 34.8 0.0 3.4e-08 33.1 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CDF33790.1 - 1.6e-06 28.4 0.0 2.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain DLH PF01738.18 CDF33790.1 - 0.00074 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 CDF33790.1 - 0.078 12.7 0.0 5.8 6.7 0.0 2.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 CDF33790.1 - 0.11 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 CDF33790.1 - 0.13 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold TamB PF04357.13 CDF33791.1 - 2e-11 43.7 0.7 2e-11 43.7 0.7 1.7 2 0 0 2 2 2 1 TamB, inner membrane protein subunit of TAM complex ATP-sulfurylase PF01747.17 CDF33792.1 - 2.5e-59 200.3 0.0 3.3e-59 199.9 0.0 1.1 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 CDF33792.1 - 5.1e-46 156.3 0.0 9.6e-46 155.4 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain CASP_C PF08172.12 CDF33793.1 - 3.3e-53 180.6 0.1 3.3e-53 180.6 0.1 3.8 3 1 0 3 3 3 2 CASP C terminal Filament PF00038.21 CDF33793.1 - 0.0018 17.9 36.0 0.014 15.0 11.3 5.0 3 2 1 5 5 5 2 Intermediate filament protein Golgin_A5 PF09787.9 CDF33793.1 - 0.014 14.9 39.7 0.021 14.3 2.8 4.3 3 2 0 3 3 3 0 Golgin subfamily A member 5 NPV_P10 PF05531.12 CDF33793.1 - 0.031 14.8 10.7 3.7 8.1 0.4 5.3 5 1 0 5 5 5 0 Nucleopolyhedrovirus P10 protein HMMR_C PF15908.5 CDF33793.1 - 0.095 13.0 0.1 0.095 13.0 0.1 4.3 3 1 1 4 4 4 0 Hyaluronan mediated motility receptor C-terminal XhlA PF10779.9 CDF33793.1 - 0.16 12.2 0.3 0.16 12.2 0.3 5.3 5 1 1 6 6 6 0 Haemolysin XhlA Phage_GP20 PF06810.11 CDF33793.1 - 0.28 11.0 22.6 0.042 13.6 3.1 5.9 3 1 4 7 7 7 0 Phage minor structural protein GP20 PKcGMP_CC PF16808.5 CDF33793.1 - 0.29 11.0 7.6 20 5.2 0.0 5.2 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Bacillus_HBL PF05791.11 CDF33793.1 - 0.34 10.7 11.0 0.55 10.0 0.0 4.3 4 1 1 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) WXG100 PF06013.12 CDF33793.1 - 0.55 10.5 18.6 0.097 12.9 2.8 5.1 5 1 1 6 6 5 0 Proteins of 100 residues with WXG Snapin_Pallidin PF14712.6 CDF33793.1 - 0.61 10.5 20.2 0.6 10.6 0.2 5.4 5 1 0 5 5 5 0 Snapin/Pallidin KxDL PF10241.9 CDF33793.1 - 0.63 10.4 15.7 0.1 12.9 5.3 3.9 4 0 0 4 4 4 0 Uncharacterized conserved protein Baculo_PEP_C PF04513.12 CDF33793.1 - 0.95 9.5 11.2 4.6 7.3 0.8 4.8 4 1 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Helitron_like_N PF14214.6 CDF33793.1 - 1.1 9.5 6.2 0.42 10.8 2.8 2.0 2 0 0 2 2 2 0 Helitron helicase-like domain at N-terminus CtIP_N PF10482.9 CDF33793.1 - 2.1 8.4 23.0 1.6 8.8 0.4 5.5 5 1 0 5 5 4 0 Tumour-suppressor protein CtIP N-terminal domain bZIP_1 PF00170.21 CDF33793.1 - 3 8.0 17.1 0.33 11.1 0.6 5.9 5 2 2 7 7 7 0 bZIP transcription factor Lectin_N PF03954.14 CDF33793.1 - 3 7.6 14.3 9 6.1 0.1 4.9 4 1 1 5 5 5 0 Hepatic lectin, N-terminal domain DHR10 PF18595.1 CDF33793.1 - 3 7.9 40.7 0.046 13.8 7.5 5.6 4 2 2 6 6 6 0 Designed helical repeat protein 10 domain V_ATPase_I PF01496.19 CDF33793.1 - 3.3 5.5 12.6 0.46 8.4 4.7 2.8 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family Csm1_N PF18504.1 CDF33793.1 - 7 7.1 33.1 0.23 11.8 0.4 7.7 4 2 3 7 7 7 0 Csm1 N-terminal domain DUF3450 PF11932.8 CDF33793.1 - 7.3 5.8 30.1 1.3 8.3 11.7 4.9 4 1 1 5 5 5 0 Protein of unknown function (DUF3450) DUF2205 PF10224.9 CDF33793.1 - 7.5 6.6 17.2 0.69 10.0 0.4 4.5 5 0 0 5 5 4 0 Short coiled-coil protein IF3_C PF00707.22 CDF33794.1 - 3.5e-15 55.7 0.2 7.4e-15 54.7 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 CDF33794.1 - 1.3e-14 54.2 0.0 3.5e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain EMP24_GP25L PF01105.24 CDF33795.1 - 1.4e-18 67.4 0.0 1.7e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ECH_1 PF00378.20 CDF33797.1 - 6.6e-74 248.4 0.0 8.2e-74 248.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDF33797.1 - 3.7e-17 62.8 0.0 4.6e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 CDF33797.1 - 0.013 14.5 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Serine dehydrogenase proteinase YjeF_N PF03853.15 CDF33798.1 - 1.8e-23 83.3 0.0 2.8e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus SLT PF01464.20 CDF33799.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain Chorismate_bind PF00425.18 CDF33800.1 - 3.8e-52 177.4 0.0 1.4e-50 172.2 0.0 2.4 1 1 0 1 1 1 1 chorismate binding enzyme TPP_enzyme_N PF02776.18 CDF33800.1 - 2.2e-27 95.8 0.0 5.6e-27 94.4 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M_2 PF16582.5 CDF33800.1 - 4.9e-12 46.0 0.0 7.1e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Middle domain of thiamine pyrophosphate TPP_enzyme_M PF00205.22 CDF33800.1 - 0.02 14.7 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain LCM PF04072.14 CDF33801.1 - 1.4e-40 139.2 0.4 1.8e-40 138.9 0.4 1.1 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase DUF3493 PF11998.8 CDF33802.1 - 8.9e-25 86.7 0.6 1.5e-24 86.0 0.6 1.4 1 0 0 1 1 1 1 Low psii accumulation1 / Rep27 DUF4174 PF13778.6 CDF33802.1 - 4.3e-07 30.4 0.0 9.9e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4174) SNAP PF14938.6 CDF33804.1 - 3.5e-94 315.4 25.7 4e-94 315.2 25.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 CDF33804.1 - 6.6e-06 26.3 13.5 0.0068 16.7 4.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat DHR-2 PF06920.13 CDF33804.1 - 0.012 14.3 3.2 0.02 13.6 3.2 1.3 1 0 0 1 1 1 0 Dock homology region 2 TPR_10 PF13374.6 CDF33804.1 - 0.022 14.6 3.0 27 4.8 0.5 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat YcxB PF14317.6 CDF33804.1 - 0.056 13.2 0.5 0.13 11.9 0.1 1.8 2 0 0 2 2 2 0 YcxB-like protein TPR_7 PF13176.6 CDF33804.1 - 0.11 12.5 10.9 23 5.3 0.0 5.3 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF33804.1 - 0.43 11.3 17.5 2.7 8.8 0.4 5.0 6 1 0 6 6 6 0 Tetratricopeptide repeat Nsp1_C PF05064.13 CDF33805.1 - 4.1e-23 81.4 0.7 7.3e-23 80.6 0.7 1.3 1 0 0 1 1 1 1 Nsp1-like C-terminal region CREPT PF16566.5 CDF33805.1 - 0.0067 16.6 0.4 0.017 15.3 0.1 1.7 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour Bul1_C PF04426.12 CDF33805.1 - 0.15 11.5 0.2 0.22 10.9 0.2 1.2 1 0 0 1 1 1 0 Bul1 C terminus Sec34 PF04136.15 CDF33805.1 - 0.16 11.8 2.2 7.7 6.4 0.8 2.2 2 0 0 2 2 2 0 Sec34-like family Corona_S2 PF01601.16 CDF33805.1 - 0.43 9.0 2.3 0.67 8.4 2.3 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein BORCS7 PF16088.5 CDF33805.1 - 0.53 10.6 2.4 1.2 9.4 2.4 1.6 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 Laminin_II PF06009.12 CDF33805.1 - 1.2 9.2 6.3 0.81 9.7 3.4 2.0 2 0 0 2 2 2 0 Laminin Domain II RFC1 PF08519.12 CDF33806.1 - 1.1e-41 142.6 0.0 4.7e-41 140.6 0.0 1.9 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.29 CDF33806.1 - 2.2e-12 47.5 0.0 6.7e-12 46.0 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 CDF33806.1 - 3.7e-12 46.4 0.0 9.1e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 CDF33806.1 - 5.6e-09 36.2 0.0 1.3e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 CDF33806.1 - 1.5e-05 24.8 0.0 3.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 CDF33806.1 - 0.0057 17.0 0.0 0.023 15.0 0.0 2.0 2 0 0 2 2 1 1 AAA C-terminal domain AAA_18 PF13238.6 CDF33806.1 - 0.0081 16.7 0.0 0.038 14.5 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF33806.1 - 0.012 15.3 0.6 0.04 13.6 0.0 2.2 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 CDF33806.1 - 0.013 15.4 3.2 0.048 13.6 0.1 2.9 3 1 0 3 3 3 0 NTPase AAA_33 PF13671.6 CDF33806.1 - 0.022 14.9 0.4 0.022 14.9 0.4 3.1 3 1 0 3 3 3 0 AAA domain PTCB-BRCT PF12738.7 CDF33806.1 - 0.022 14.7 0.0 0.054 13.4 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain AAA_5 PF07728.14 CDF33806.1 - 0.024 14.7 0.0 0.13 12.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CDF33806.1 - 0.032 14.6 0.0 0.39 11.1 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.6 CDF33806.1 - 0.046 14.1 0.2 0.54 10.6 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain TIP49 PF06068.13 CDF33806.1 - 0.076 12.2 0.0 0.71 9.0 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain API5 PF05918.11 CDF33806.1 - 1 8.1 4.5 1.8 7.3 4.5 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) ORC6 PF05460.13 CDF33806.1 - 7.9 5.6 12.9 0.36 10.1 6.2 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Pkinase PF00069.25 CDF33807.1 - 1.2e-59 201.8 0.0 1.6e-59 201.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33807.1 - 3.6e-33 115.0 0.0 4.6e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF33807.1 - 2.7e-10 40.0 0.0 4.9e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 CDF33807.1 - 0.0038 16.9 0.0 1.4 8.5 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Fis1_TPR_C PF14853.6 CDF33807.1 - 0.14 12.3 0.1 4.2 7.5 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat DEAD PF00270.29 CDF33809.1 - 1.5e-46 158.3 0.0 2.8e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF33809.1 - 4.3e-25 88.2 0.0 1.7e-24 86.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GUCT PF08152.12 CDF33809.1 - 8e-17 61.3 0.0 2.9e-16 59.5 0.0 2.0 2 0 0 2 2 2 1 GUCT (NUC152) domain ResIII PF04851.15 CDF33809.1 - 0.00013 22.1 1.5 0.001 19.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDF33809.1 - 0.077 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain SR-25 PF10500.9 CDF33809.1 - 0.086 12.4 23.3 0.14 11.7 23.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CMS1 PF14617.6 CDF33809.1 - 0.23 10.7 0.0 0.23 10.7 0.0 3.1 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit DUF2151 PF10221.9 CDF33809.1 - 0.77 8.3 7.7 1.1 7.7 7.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator CENP-N PF05238.13 CDF33809.1 - 1.6 7.9 7.8 2.4 7.4 7.8 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like AP3D1 PF06375.11 CDF33809.1 - 2.6 8.3 19.4 5.1 7.3 19.4 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Presenilin PF01080.17 CDF33809.1 - 3.6 6.2 7.9 5.6 5.6 7.9 1.2 1 0 0 1 1 1 0 Presenilin U79_P34 PF03064.16 CDF33809.1 - 7.1 5.9 18.7 14 5.0 18.7 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 RR_TM4-6 PF06459.12 CDF33809.1 - 9.1 6.0 12.4 16 5.2 12.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.25 CDF33810.1 - 1.2e-55 188.7 0.0 9.9e-55 185.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33810.1 - 1.6e-31 109.6 0.0 2.2e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF33810.1 - 5e-09 35.9 0.0 1.3e-08 34.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDF33810.1 - 0.004 16.0 0.0 0.0069 15.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase zf-UBR PF02207.20 CDF33811.1 - 8.1e-19 67.6 15.4 8.1e-19 67.6 15.4 3.1 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 CDF33811.1 - 6.9 6.9 16.7 0.86 9.8 3.3 3.2 3 0 0 3 3 3 0 B-box zinc finger LRR_4 PF12799.7 CDF33816.1 - 1.3e-24 85.9 14.2 9.3e-07 29.1 0.2 5.8 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDF33816.1 - 7.1e-19 67.3 16.6 2.5e-08 33.6 1.3 4.7 1 1 4 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 CDF33816.1 - 7.5e-13 48.3 4.3 8.8e-07 28.6 1.4 3.2 2 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 CDF33816.1 - 1.4e-06 28.0 6.1 7.9 7.5 0.2 6.9 5 3 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 CDF33816.1 - 3.9e-05 23.4 17.6 1.1 9.5 0.2 7.0 7 0 0 7 7 7 2 Leucine Rich repeat DUF429 PF04250.13 CDF33816.1 - 0.072 12.9 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF429) TP53IP5 PF15331.6 CDF33816.1 - 7.8 6.6 10.3 4.5 7.4 0.1 2.5 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 tRNA_m1G_MT PF01746.21 CDF33817.1 - 1.2e-16 61.0 0.0 2.1e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase FAM199X PF15814.5 CDF33817.1 - 3.9 6.4 11.6 5.9 5.9 11.6 1.3 1 0 0 1 1 1 0 Protein family FAM199X RCC1 PF00415.18 CDF33819.1 - 1.8e-32 111.7 11.7 3e-12 47.0 0.0 6.0 5 1 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDF33819.1 - 1.2e-27 95.1 13.0 4.1e-08 32.8 0.8 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 CDF33819.1 - 0.12 12.4 0.2 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Kelch motif dUTPase PF00692.19 CDF33821.1 - 1.9e-42 144.0 0.0 2.3e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 dUTPase ABC_tran PF00005.27 CDF33822.1 - 2e-37 128.8 0.0 2.7e-17 63.5 0.0 2.3 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 CDF33822.1 - 4.4e-13 48.8 3.8 1.2e-12 47.4 3.8 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 CDF33822.1 - 6.4e-13 48.7 1.7 0.00025 20.6 0.0 4.0 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDF33822.1 - 5.7e-11 42.8 4.5 0.074 12.8 0.0 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 CDF33822.1 - 7.4e-07 28.7 3.4 7.4e-07 28.7 3.4 2.7 3 0 0 3 3 2 1 4Fe-4S binding domain AAA PF00004.29 CDF33822.1 - 2.1e-06 28.2 0.0 0.11 12.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CDF33822.1 - 3.7e-06 26.9 0.0 0.16 11.6 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_16 PF13191.6 CDF33822.1 - 1.8e-05 25.2 0.0 0.25 11.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDF33822.1 - 2e-05 24.2 0.1 0.29 10.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDF33822.1 - 6.9e-05 22.8 0.0 0.51 10.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 CDF33822.1 - 7.5e-05 22.7 0.1 0.09 12.7 0.0 2.4 2 0 0 2 2 2 2 NACHT domain Thymidylate_kin PF02223.17 CDF33822.1 - 9.3e-05 22.2 0.0 0.018 14.7 0.0 2.9 3 0 0 3 3 3 1 Thymidylate kinase TsaE PF02367.17 CDF33822.1 - 0.00016 21.7 0.0 0.097 12.7 0.0 2.7 3 0 0 3 3 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 CDF33822.1 - 0.00017 21.3 1.2 0.19 11.3 0.0 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_33 PF13671.6 CDF33822.1 - 0.00032 20.9 0.0 0.67 10.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CDF33822.1 - 0.00033 21.2 0.2 0.082 13.4 0.2 2.4 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 CDF33822.1 - 0.00044 20.2 0.0 0.02 14.8 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 CDF33822.1 - 0.00054 20.2 0.0 0.43 10.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDF33822.1 - 0.0006 19.6 0.1 0.51 10.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CDF33822.1 - 0.0008 19.4 0.5 0.23 11.5 0.0 3.1 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CDF33822.1 - 0.0013 19.1 0.0 2.2 8.7 0.0 2.8 3 0 0 3 3 2 1 RNA helicase Fer4_6 PF12837.7 CDF33822.1 - 0.0018 18.3 3.2 0.0018 18.3 3.2 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_7 PF12838.7 CDF33822.1 - 0.002 18.7 1.1 0.002 18.7 1.1 2.4 2 1 2 4 4 3 2 4Fe-4S dicluster domain AAA_24 PF13479.6 CDF33822.1 - 0.0028 17.4 0.2 0.48 10.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CDF33822.1 - 0.0047 17.2 0.3 2.3 8.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain Fer4_10 PF13237.6 CDF33822.1 - 0.0053 16.8 1.1 0.0053 16.8 1.1 2.7 2 1 1 3 3 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDF33822.1 - 0.0071 16.5 10.6 0.014 15.5 9.2 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain AAA_18 PF13238.6 CDF33822.1 - 0.012 16.1 0.0 2.9 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 CDF33822.1 - 0.013 16.4 0.2 0.013 16.4 0.2 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_7 PF12775.7 CDF33822.1 - 0.014 14.9 0.0 0.95 8.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region SbcCD_C PF13558.6 CDF33822.1 - 0.021 15.1 0.0 7.5 6.9 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 CDF33822.1 - 0.022 13.9 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 CDF33822.1 - 0.03 13.5 0.0 2.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Fer4_2 PF12797.7 CDF33822.1 - 0.032 14.3 1.9 0.032 14.3 1.9 2.8 3 0 0 3 3 2 0 4Fe-4S binding domain NTPase_1 PF03266.15 CDF33822.1 - 0.042 13.8 3.5 14 5.5 0.0 4.2 5 0 0 5 5 4 0 NTPase MMR_HSR1 PF01926.23 CDF33822.1 - 0.05 13.7 0.2 12 6.1 0.0 2.9 3 1 0 3 3 2 0 50S ribosome-binding GTPase AAA_14 PF13173.6 CDF33822.1 - 0.078 13.0 0.0 15 5.6 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_13 PF13166.6 CDF33822.1 - 0.11 11.1 0.6 0.38 9.3 0.0 2.1 3 0 0 3 3 2 0 AAA domain TniB PF05621.11 CDF33822.1 - 0.11 11.9 0.3 1.6 8.1 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein G-alpha PF00503.20 CDF33822.1 - 0.14 11.3 0.0 6.8 5.7 0.0 3.0 3 1 1 4 4 4 0 G-protein alpha subunit Fer4_21 PF14697.6 CDF33822.1 - 0.14 12.3 16.5 0.041 14.0 12.5 2.1 2 1 0 2 2 2 0 4Fe-4S dicluster domain Zeta_toxin PF06414.12 CDF33822.1 - 0.15 11.4 0.0 4.8 6.4 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin RuvB_N PF05496.12 CDF33822.1 - 0.16 11.7 0.3 17 5.2 0.0 3.0 3 1 0 3 3 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 CDF33822.1 - 0.18 12.1 0.3 6.5 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 CDF33822.1 - 0.2 10.6 0.2 0.61 9.0 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2878 PF11086.8 CDF33823.1 - 0.072 13.3 0.0 0.094 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2878) Sec34 PF04136.15 CDF33824.1 - 2.2e-23 82.8 0.0 3.7e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Sec34-like family Methyltransf_11 PF08241.12 CDF33826.1 - 1.1e-19 70.9 0.0 1.6e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF33826.1 - 1.3e-17 64.3 0.0 2e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF33826.1 - 1.2e-16 60.8 0.0 4.5e-16 58.9 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDF33826.1 - 1.4e-10 41.2 0.0 1.8e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF33826.1 - 2.9e-10 40.8 0.0 5.1e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF33826.1 - 9.8e-10 38.5 0.0 1.6e-09 37.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF33826.1 - 0.023 14.3 0.0 0.048 13.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_8 PF05148.15 CDF33826.1 - 0.047 13.5 0.0 0.15 11.9 0.0 1.6 1 1 1 2 2 2 0 Hypothetical methyltransferase GTP_EFTU PF00009.27 CDF33832.1 - 1.5e-49 168.2 0.0 2.6e-49 167.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CDF33832.1 - 9.5e-47 157.6 1.2 1.5e-46 156.9 1.2 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CDF33832.1 - 6.8e-18 64.5 0.0 1.6e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF33832.1 - 3.8e-07 30.4 0.3 7.5e-07 29.5 0.3 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF33832.1 - 1.9e-06 27.9 0.0 4.6e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CDF33832.1 - 0.00014 21.4 0.0 0.00044 19.7 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit EFG_II PF14492.6 CDF33832.1 - 0.00021 21.3 0.0 0.00074 19.6 0.0 2.0 1 1 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 CDF33832.1 - 0.0013 18.5 0.0 0.0039 17.0 0.0 1.7 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1_Xtn PF16897.5 CDF33832.1 - 0.017 15.2 0.0 0.079 13.0 0.0 2.0 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CDF33832.1 - 0.065 12.8 0.0 0.19 11.2 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 CDF33832.1 - 0.086 12.6 0.0 11 5.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 CDF33832.1 - 0.094 12.5 0.0 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CSN8_PSD8_EIF3K PF10075.9 CDF33833.1 - 1.5e-24 86.6 0.0 2.6e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 CDF33833.1 - 0.0014 18.1 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family Glyco_transf_20 PF00982.21 CDF33834.1 - 6.6e-134 447.1 0.0 8.3e-134 446.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CDF33834.1 - 6.2e-35 120.4 0.0 5.9e-25 87.8 0.0 2.1 2 0 0 2 2 2 2 Trehalose-phosphatase ArfGap PF01412.18 CDF33835.1 - 2.5e-33 114.6 2.0 4.6e-33 113.8 0.4 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_4 PF13637.6 CDF33838.1 - 1.1e-31 108.8 3.0 7e-09 36.0 0.0 5.2 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDF33838.1 - 3.9e-28 97.9 2.3 2.6e-16 60.0 0.2 4.1 2 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDF33838.1 - 4.7e-27 93.7 5.7 8.4e-09 35.5 0.1 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDF33838.1 - 2.5e-24 82.7 2.7 0.00025 21.2 0.0 6.2 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 CDF33838.1 - 2.2e-22 78.5 0.4 1.2e-05 25.5 0.1 6.1 6 0 0 6 6 6 5 Ankyrin repeat FAD_binding_5 PF00941.21 CDF33838.1 - 0.13 11.9 0.8 0.77 9.5 0.1 2.3 2 1 0 2 2 2 0 FAD binding domain in molybdopterin dehydrogenase Asparaginase_2 PF01112.18 CDF33840.1 - 3.2e-93 312.1 10.3 3.6e-93 311.9 10.3 1.0 1 0 0 1 1 1 1 Asparaginase TIG PF01833.24 CDF33841.1 - 5e-14 52.1 0.1 1.2e-06 28.5 0.0 2.7 2 0 0 2 2 2 2 IPT/TIG domain GSDH PF07995.11 CDF33841.1 - 2.9e-07 30.1 0.0 5.9e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase PA14 PF07691.12 CDF33841.1 - 2.7e-05 24.0 0.0 8.4e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 PA14 domain TIG PF01833.24 CDF33842.1 - 1.2e-10 41.3 0.1 0.00044 20.3 0.1 2.5 2 0 0 2 2 2 2 IPT/TIG domain DEAD PF00270.29 CDF33843.1 - 1.6e-50 171.3 0.0 2.4e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF33843.1 - 1.2e-31 109.4 0.0 6.2e-31 107.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF33843.1 - 0.0037 17.3 0.0 0.0065 16.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDF33843.1 - 0.093 13.0 0.1 0.5 10.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain ERCC3_RAD25_C PF16203.5 CDF33843.1 - 0.19 10.9 0.0 0.31 10.2 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF3458_C PF17432.2 CDF33844.1 - 2.3e-104 349.2 0.0 3.8e-104 348.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 CDF33844.1 - 6.7e-48 163.1 0.0 1e-47 162.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 CDF33844.1 - 6.6e-25 87.4 0.0 1.3e-24 86.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 CDF33844.1 - 1.6e-10 41.5 0.0 3.2e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 CDF33844.1 - 0.006 17.0 0.2 0.17 12.3 0.2 2.5 1 1 0 1 1 1 1 M61 glycyl aminopeptidase Acyltransferase PF01553.21 CDF33845.1 - 3e-16 59.3 0.0 4.5e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CDF33845.1 - 3.2e-15 56.0 0.9 6.2e-15 55.0 0.9 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus zf-C3HC4_3 PF13920.6 CDF33847.1 - 8.6e-11 41.5 7.9 1.4e-10 40.8 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF33847.1 - 6.7e-07 29.1 7.7 1.3e-06 28.2 7.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CDF33847.1 - 8.2e-05 22.4 7.8 0.00015 21.5 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF33847.1 - 9.8e-05 22.6 8.7 9.8e-05 22.6 8.7 1.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CDF33847.1 - 0.00026 20.9 7.4 0.00051 20.0 7.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDF33847.1 - 0.0073 16.1 8.3 0.013 15.3 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CDF33847.1 - 5.5 6.9 7.0 16 5.4 7.0 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Lipase_3 PF01764.25 CDF33849.1 - 5e-20 71.8 0.0 1.9e-18 66.7 0.0 2.8 2 1 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CDF33849.1 - 0.041 14.5 0.4 0.44 11.1 0.0 2.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF2867 PF11066.8 CDF33849.1 - 0.1 12.9 0.0 2 8.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2867) GRASP55_65 PF04495.14 CDF33850.1 - 9.1e-48 162.1 0.0 2.7e-35 121.7 0.0 2.0 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 CDF33850.1 - 4.7e-09 35.9 0.3 0.00075 19.3 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CDF33850.1 - 1.3e-08 35.1 0.1 3.4e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CDF33850.1 - 0.012 15.9 0.0 0.44 10.9 0.0 2.2 2 0 0 2 2 2 0 PDZ domain FancD2 PF14631.6 CDF33852.1 - 0.00029 18.4 0.1 0.00032 18.3 0.1 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease FANCI_S1 PF14675.6 CDF33852.1 - 0.0068 16.0 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 FANCI solenoid 1 DUF2285 PF10074.9 CDF33852.1 - 0.078 13.6 0.5 0.16 12.6 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2285) Glyco_transf_90 PF05686.12 CDF33853.1 - 5.7e-26 91.3 0.4 1.7e-25 89.8 0.0 1.9 1 1 1 2 2 2 1 Glycosyl transferase family 90 ADH_N PF08240.12 CDF33854.1 - 2.2e-07 30.7 0.0 6.8e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CDF33854.1 - 4.8e-05 23.4 0.0 8.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDF33854.1 - 0.14 13.3 0.0 0.4 11.7 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Glycos_transf_1 PF00534.20 CDF33856.1 - 5.1e-25 88.0 0.0 9.4e-25 87.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF33856.1 - 1.8e-21 77.0 0.2 5.3e-21 75.4 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF1752 PF08550.10 CDF33856.1 - 7e-11 41.8 0.6 1.5e-10 40.7 0.6 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Glyco_trans_1_2 PF13524.6 CDF33856.1 - 2.6e-10 40.6 0.0 1.3e-09 38.3 0.0 2.2 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDF33856.1 - 3.5e-05 23.9 0.0 0.00011 22.2 0.0 2.0 2 1 0 2 2 2 1 Glycosyltransferase Family 4 LcrG PF07216.12 CDF33856.1 - 0.03 14.2 0.9 0.14 12.1 0.4 2.2 2 0 0 2 2 2 0 LcrG protein DUF2280 PF10045.9 CDF33856.1 - 0.12 12.7 0.1 0.27 11.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) MFS_1 PF07690.16 CDF33858.1 - 3.1e-17 62.5 26.7 3.1e-17 62.5 26.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CDF33858.1 - 1.1e-12 47.3 5.3 1.1e-12 47.3 5.3 2.5 2 1 0 2 2 2 2 MFS/sugar transport protein PUCC PF03209.15 CDF33858.1 - 1e-06 28.1 1.3 1e-06 28.1 1.3 3.1 2 1 1 3 3 3 1 PUCC protein PRIMA1 PF16101.5 CDF33858.1 - 0.00011 22.2 0.5 0.0077 16.3 0.0 2.4 2 0 0 2 2 2 1 Proline-rich membrane anchor 1 MFS_1_like PF12832.7 CDF33858.1 - 0.097 11.5 11.4 0.11 11.3 3.4 2.8 2 2 0 2 2 2 0 MFS_1 like family Carb_kinase PF01256.17 CDF33859.1 - 9e-47 159.6 0.0 1.2e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase Sulfotransfer_3 PF13469.6 CDF33860.1 - 0.00034 21.1 0.9 0.00049 20.5 0.2 1.7 2 1 0 2 2 2 1 Sulfotransferase family SCP1201-deam PF14428.6 CDF33864.1 - 0.054 13.4 0.1 0.17 11.8 0.0 1.7 1 1 1 2 2 2 0 SCP1.201-like deaminase Hint PF01079.20 CDF33865.1 - 7e-26 91.1 0.0 7.9e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 Hint module Asparaginase PF00710.20 CDF33866.1 - 4.3e-57 192.8 0.0 1.2e-56 191.3 0.0 1.6 1 1 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CDF33866.1 - 2.8e-15 56.5 0.0 5.4e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain MFS_1 PF07690.16 CDF33867.1 - 1.9e-16 59.9 38.2 2.6e-16 59.5 26.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CDF33867.1 - 1.3e-10 40.4 9.9 1.3e-10 40.4 9.9 3.4 3 1 1 4 4 4 2 MFS/sugar transport protein Sel1 PF08238.12 CDF33868.1 - 8.8e-05 23.1 6.5 13 6.6 0.0 5.5 5 0 0 5 5 5 3 Sel1 repeat TPR_17 PF13431.6 CDF33868.1 - 0.016 15.5 1.9 0.39 11.2 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HECT PF00632.25 CDF33869.1 - 1.4e-69 235.0 0.0 2e-69 234.4 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Arm PF00514.23 CDF33869.1 - 3.3e-10 39.6 0.8 0.053 13.6 0.0 4.8 3 1 1 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDF33869.1 - 0.00011 22.6 0.2 0.38 11.3 0.0 3.2 2 0 0 2 2 2 2 HEAT-like repeat HEAT PF02985.22 CDF33869.1 - 0.00015 21.7 0.1 2.8 8.4 0.0 4.1 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 CDF33869.1 - 0.0024 18.2 0.2 1.3 9.4 0.0 4.2 3 0 0 3 3 3 1 HEAT repeats PALP PF00291.25 CDF33870.1 - 9.4e-73 245.2 3.2 1e-72 245.0 3.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SAM_decarbox PF01536.16 CDF33874.1 - 7.4e-86 288.3 0.0 9.3e-86 288.0 0.0 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase AdoMet_dc PF02675.15 CDF33874.1 - 0.0021 18.3 0.0 0.0076 16.5 0.0 1.9 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase DUF962 PF06127.11 CDF33879.1 - 3.6e-13 49.4 1.1 5.2e-13 48.9 1.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF962) HKR_ArcB_TM PF18415.1 CDF33879.1 - 5.1 8.0 8.3 1.2 10.0 1.0 2.3 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain Yip1 PF04893.17 CDF33881.1 - 5.7e-11 42.4 9.7 8.7e-11 41.8 9.7 1.3 1 0 0 1 1 1 1 Yip1 domain E1-E2_ATPase PF00122.20 CDF33881.1 - 0.073 12.6 1.4 0.12 11.9 1.4 1.4 1 0 0 1 1 1 0 E1-E2 ATPase PD40 PF07676.12 CDF33882.1 - 0.0013 18.7 1.8 0.036 14.0 0.0 3.3 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DNA_pol_phi PF04931.13 CDF33882.1 - 0.88 7.6 4.2 1.2 7.2 4.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi MAPKK1_Int PF08923.10 CDF33883.1 - 0.17 11.7 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting Glyco_transf_7C PF02709.14 CDF33884.1 - 1.1e-06 28.2 0.0 2.4e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDF33884.1 - 0.00088 18.8 0.0 0.0066 16.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 BCAS3 PF12490.8 CDF33885.1 - 0.08 12.4 4.5 0.11 12.0 4.5 1.1 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 DUF3827 PF12877.7 CDF33885.1 - 0.69 8.2 10.3 0.79 8.0 10.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF4337 PF14235.6 CDF33885.1 - 3.5 7.7 4.5 4.6 7.3 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) RR_TM4-6 PF06459.12 CDF33885.1 - 3.5 7.4 9.1 4.5 7.0 9.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-C2H2_jaz PF12171.8 CDF33886.1 - 0.0089 16.3 0.2 0.02 15.1 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDF33886.1 - 0.027 14.8 0.1 0.069 13.6 0.1 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Dopey_N PF04118.14 CDF33887.1 - 1.4e-79 267.4 0.0 2.8e-79 266.4 0.0 1.5 1 0 0 1 1 1 1 Dopey, N-terminal NADH-u_ox-rdase PF10785.9 CDF33888.1 - 8.4e-16 58.4 0.3 1.4e-15 57.7 0.3 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF1295 PF06966.12 CDF33889.1 - 4.9e-73 245.5 4.8 5.9e-73 245.3 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 CDF33889.1 - 0.027 14.4 0.1 0.027 14.4 0.1 1.9 2 1 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 CDF33889.1 - 0.13 12.7 0.0 0.13 12.7 0.0 2.8 4 0 0 4 4 4 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Acyltransf_C PF16076.5 CDF33891.1 - 0.023 14.8 0.0 0.028 14.5 0.0 1.1 1 0 0 1 1 1 0 Acyltransferase C-terminus MTS PF05175.14 CDF33892.1 - 4.3e-08 32.9 0.0 2.4e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDF33892.1 - 2.4e-05 25.0 0.0 5.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF33892.1 - 0.00011 22.1 0.0 0.00015 21.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CDF33892.1 - 0.0006 19.5 0.0 0.00083 19.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Cons_hypoth95 PF03602.15 CDF33892.1 - 0.00076 19.2 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 CDF33892.1 - 0.00087 19.9 0.0 0.0054 17.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF33892.1 - 0.0063 16.4 0.0 0.024 14.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF33892.1 - 0.013 16.2 0.0 0.031 15.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain PrmA PF06325.13 CDF33892.1 - 0.11 11.9 0.1 2.2 7.6 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) AA_permease_2 PF13520.6 CDF33893.1 - 1.2e-39 136.4 33.0 1.2e-39 136.4 33.0 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDF33893.1 - 1.4e-22 80.0 31.9 1.4e-22 80.0 31.9 1.6 1 1 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 CDF33893.1 - 4.7e-12 45.8 1.3 3.1e-11 43.2 1.3 2.6 1 0 0 1 1 1 1 C-terminus of AA_permease Spore_permease PF03845.13 CDF33893.1 - 0.0021 17.0 7.2 0.0021 17.0 7.2 2.1 2 0 0 2 2 2 1 Spore germination protein Pkinase PF00069.25 CDF33904.1 - 4.4e-05 23.0 0.0 8.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TIP49 PF06068.13 CDF33905.1 - 1.6e-70 238.1 3.7 2.4e-42 145.4 0.0 2.0 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 CDF33905.1 - 6.6e-10 39.0 0.1 3.3e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain PaaX PF07848.12 CDF33905.1 - 0.077 13.2 0.0 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 PaaX-like protein SAC3_GANP PF03399.16 CDF33908.1 - 1.7e-93 313.3 1.2 2.7e-93 312.6 1.2 1.3 1 0 0 1 1 1 1 SAC3/GANP family RRM_1 PF00076.22 CDF33908.1 - 4.8e-06 26.3 0.1 0.034 14.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 CDF33908.1 - 0.51 10.6 7.6 8.2 6.6 0.0 4.5 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter APG6_N PF17675.1 CDF33908.1 - 0.8 10.2 18.6 0.72 10.4 11.4 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region ERM PF00769.19 CDF33908.1 - 5 6.9 24.0 1 9.2 2.3 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 CDF33908.1 - 6.9 5.9 14.1 14 4.9 8.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) WD40 PF00400.32 CDF33909.1 - 3.5e-06 27.6 11.1 0.0071 17.2 0.6 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat CBF PF03914.17 CDF33910.1 - 2.2e-41 141.7 0.2 1.1e-40 139.5 0.0 2.2 2 0 0 2 2 2 1 CBF/Mak21 family Cnd1 PF12717.7 CDF33910.1 - 0.00023 21.2 0.3 0.013 15.5 0.3 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 AP3D1 PF06375.11 CDF33910.1 - 0.3 11.3 12.1 3.2 8.0 3.8 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 NOC3p PF07540.11 CDF33910.1 - 0.83 10.1 5.2 2 8.9 0.0 3.5 4 0 0 4 4 4 0 Nucleolar complex-associated protein Tubulin_3 PF14881.6 CDF33911.1 - 2.5e-12 46.9 0.0 4.5e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain RNA_pol_Rpb2_6 PF00562.28 CDF33913.1 - 2e-107 359.7 0.0 2.6e-107 359.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDF33913.1 - 9.8e-28 97.0 0.0 1.6e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CDF33913.1 - 1.4e-26 92.4 0.0 4.6e-26 90.8 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 CDF33913.1 - 6.1e-21 74.6 0.2 1.2e-20 73.7 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 CDF33913.1 - 5.4e-10 39.1 0.2 1.1e-09 38.2 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 CDF33913.1 - 7e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 CDF33913.1 - 0.00069 19.9 0.1 0.0022 18.2 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 NFACT-R_1 PF05670.13 CDF33917.1 - 3.4e-29 101.7 0.2 1.1e-28 100.0 0.0 2.0 2 0 0 2 2 2 1 NFACT protein RNA binding domain FbpA PF05833.11 CDF33917.1 - 8.5e-25 87.4 0.0 6.3e-24 84.6 0.0 2.1 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 CDF33917.1 - 1.8e-24 85.7 0.5 7.9e-24 83.6 0.0 2.5 2 0 0 2 2 2 1 NFACT protein C-terminal domain DUF5590 PF17881.1 CDF33917.1 - 0.0041 17.2 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5590) Sec63 PF02889.16 CDF33920.1 - 6.6e-54 182.8 0.0 1.4e-53 181.7 0.0 1.5 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CDF33920.1 - 6.2e-35 120.5 0.0 1.9e-27 96.2 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 CDF33920.1 - 5.7e-13 49.2 0.0 2e-11 44.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDF33920.1 - 3.5e-10 40.2 0.0 0.00036 20.9 0.0 3.5 3 0 0 3 3 3 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 CDF33920.1 - 3.4e-07 30.2 0.1 4.9e-05 23.1 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 CDF33920.1 - 0.00014 22.2 0.1 0.002 18.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDF33920.1 - 0.0084 16.4 0.6 0.048 13.9 0.1 2.5 3 1 0 3 3 3 1 AAA domain FliT PF05400.13 CDF33920.1 - 0.14 13.0 4.4 3.8 8.4 0.0 4.1 4 0 0 4 4 4 0 Flagellar protein FliT PAP2 PF01569.21 CDF33921.1 - 1.7e-22 79.6 7.9 2.9e-22 78.9 3.2 2.2 2 0 0 2 2 2 2 PAP2 superfamily PAP2_3 PF14378.6 CDF33921.1 - 1.6 8.4 16.7 16 5.1 16.7 2.5 1 1 0 1 1 1 0 PAP2 superfamily Thioredoxin_7 PF13899.6 CDF33923.1 - 5.7e-17 61.7 0.0 1.4e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 CDF33923.1 - 1.3e-14 54.1 0.0 2.5e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 CDF33923.1 - 5e-10 39.0 0.3 1.1e-09 37.9 0.3 1.6 1 0 0 1 1 1 1 UBA-like domain Thioredox_DsbH PF03190.15 CDF33923.1 - 0.00065 19.7 0.1 0.0012 18.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 UIM PF02809.20 CDF33923.1 - 0.053 13.5 0.5 0.053 13.5 0.5 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Rxt3 PF08642.10 CDF33924.1 - 9.8e-09 36.1 0.0 1.7e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 C2 PF00168.30 CDF33925.1 - 2.2e-05 24.7 0.0 0.00038 20.7 0.0 2.3 2 0 0 2 2 2 1 C2 domain Mito_carr PF00153.27 CDF33926.1 - 2e-68 226.4 2.2 3.8e-22 78.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDF33926.1 - 0.22 10.7 2.5 21 4.1 0.1 3.4 2 1 0 3 3 3 0 Gammaproteobacterial serine protease PHD PF00628.29 CDF33927.1 - 0.0028 17.5 10.9 0.0034 17.3 9.1 2.1 1 1 1 2 2 2 1 PHD-finger C1_1 PF00130.22 CDF33927.1 - 0.08 12.8 8.1 0.037 13.9 4.6 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Surface_antigen PF11054.8 CDF33927.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen tRNA-synt_2d PF01409.20 CDF33928.1 - 3.2e-52 177.4 0.0 5.9e-52 176.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 CDF33928.1 - 8.7e-21 74.2 0.0 2.5e-20 72.7 0.0 1.8 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 CDF33928.1 - 0.15 11.1 0.0 2.4 7.2 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) Pyr_redox_2 PF07992.14 CDF33929.1 - 2.4e-72 243.6 5.1 3.7e-72 243.0 5.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDF33929.1 - 1e-38 132.0 0.8 2.6e-38 130.7 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDF33929.1 - 9.9e-24 83.7 6.7 2.8e-18 66.3 0.6 3.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDF33929.1 - 1.9e-14 53.6 4.0 2.2e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDF33929.1 - 3.9e-11 43.0 4.0 2e-10 40.6 0.4 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 CDF33929.1 - 6.6e-11 41.9 1.7 4.6e-09 35.8 0.8 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDF33929.1 - 2.6e-09 36.7 8.3 5.4e-07 29.0 2.3 3.6 3 1 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.21 CDF33929.1 - 5.2e-09 35.7 3.1 0.0022 17.3 0.0 3.6 3 1 1 4 4 4 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 CDF33929.1 - 8.5e-08 32.3 5.1 4.3e-06 26.9 0.5 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CDF33929.1 - 5.2e-07 29.1 0.9 0.042 13.0 0.0 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CDF33929.1 - 1.1e-05 24.8 0.5 9.3e-05 21.8 0.0 2.5 3 0 0 3 3 3 1 Thi4 family HI0933_like PF03486.14 CDF33929.1 - 3.6e-05 22.6 12.6 0.00045 19.0 1.5 3.5 3 1 1 4 4 4 2 HI0933-like protein DAO PF01266.24 CDF33929.1 - 0.00022 20.9 10.1 0.0077 15.8 0.5 3.8 4 0 0 4 4 4 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDF33929.1 - 0.0039 16.3 2.3 0.016 14.3 0.2 2.5 2 1 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 CDF33929.1 - 0.0066 15.7 9.0 0.055 12.7 0.9 3.0 3 0 0 3 3 3 1 FAD binding domain XdhC_C PF13478.6 CDF33929.1 - 0.007 16.9 0.1 0.85 10.1 0.0 2.4 2 0 0 2 2 2 1 XdhC Rossmann domain 3HCDH_N PF02737.18 CDF33929.1 - 0.023 14.6 4.8 0.035 14.0 0.2 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CDF33929.1 - 0.04 14.4 0.5 10 6.6 0.1 2.8 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 CDF33929.1 - 0.12 12.4 1.1 2.3 8.2 0.2 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding NFACT-R_1 PF05670.13 CDF33930.1 - 1.3e-43 148.1 0.8 1.3e-43 148.1 0.8 1.6 2 0 0 2 2 2 1 NFACT protein RNA binding domain Nucleoporin2 PF04096.14 CDF33930.1 - 3.5e-05 24.0 1.9 5.2e-05 23.4 1.9 1.2 1 0 0 1 1 1 1 Nucleoporin autopeptidase LMBR1 PF04791.16 CDF33930.1 - 0.22 10.4 1.5 0.23 10.4 1.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PsbU PF06514.11 CDF33931.1 - 9e-26 89.7 0.1 1.2e-25 89.3 0.1 1.2 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) HHH_3 PF12836.7 CDF33931.1 - 0.0014 18.8 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif PsbQ PF05757.11 CDF33931.1 - 0.0054 16.5 0.6 0.0066 16.2 0.6 1.2 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) MSP PF01716.18 CDF33932.1 - 1e-93 313.0 1.6 1.2e-93 312.8 1.6 1.0 1 0 0 1 1 1 1 Manganese-stabilising protein / photosystem II polypeptide DUF3188 PF11384.8 CDF33934.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) zf-Sec23_Sec24 PF04810.15 CDF33938.1 - 0.13 12.4 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Cyto_heme_lyase PF01265.17 CDF33941.1 - 2e-55 188.5 13.6 1e-54 186.2 13.6 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase ATP_bind_3 PF01171.20 CDF33943.1 - 2.7e-35 121.8 0.0 3.8e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 PP-loop family Glucosamine_iso PF01182.20 CDF33943.1 - 0.042 13.7 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase TilS PF09179.11 CDF33943.1 - 0.062 13.8 1.4 0.1 13.1 0.1 2.1 2 0 0 2 2 2 0 TilS substrate binding domain PIF1 PF05970.14 CDF33944.1 - 1.1e-97 327.5 0.0 1.4e-97 327.1 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF33944.1 - 3.3e-28 99.2 0.0 1.3e-27 97.3 0.0 1.8 1 1 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF33944.1 - 7.5e-12 45.4 0.0 1.4e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF33944.1 - 0.0099 16.2 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF33944.1 - 0.049 11.6 0.0 0.076 10.9 0.0 1.1 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF33944.1 - 0.081 12.8 0.1 0.43 10.4 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 CDF33944.1 - 0.18 11.6 0.1 13 5.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain zf-RING_2 PF13639.6 CDF33945.1 - 1.7e-12 47.4 7.7 3.8e-12 46.3 7.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDF33945.1 - 2e-10 40.2 1.5 5.7e-10 38.8 1.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF33945.1 - 8.6e-09 35.1 7.2 1.6e-08 34.2 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF33945.1 - 1.5e-08 34.4 6.1 3.4e-08 33.2 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF33945.1 - 5.5e-07 29.8 7.1 1.6e-06 28.3 7.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CDF33945.1 - 1.2e-05 25.1 6.3 2.3e-05 24.3 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDF33945.1 - 1.4e-05 24.8 5.2 3.2e-05 23.7 5.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF33945.1 - 2.4e-05 24.1 6.9 5.3e-05 23.0 6.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PA PF02225.22 CDF33945.1 - 7.7e-05 22.6 0.0 0.00022 21.2 0.0 1.8 2 0 0 2 2 2 1 PA domain zf-RING_UBOX PF13445.6 CDF33945.1 - 8.8e-05 22.4 2.2 8.8e-05 22.4 2.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CDF33945.1 - 0.016 15.2 4.8 0.055 13.5 4.8 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 CDF33945.1 - 0.056 13.6 4.9 0.14 12.3 4.9 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 CDF33945.1 - 0.12 12.5 4.1 0.058 13.5 1.5 1.7 2 0 0 2 2 1 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 CDF33945.1 - 0.15 11.7 6.2 0.37 10.4 6.2 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 CDF33945.1 - 0.26 11.1 9.3 0.06 13.2 5.1 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain PHD PF00628.29 CDF33945.1 - 0.31 10.9 6.5 0.64 10.0 6.5 1.6 1 0 0 1 1 1 0 PHD-finger Rad50_zn_hook PF04423.14 CDF33945.1 - 0.4 10.5 6.0 0.13 12.1 2.4 2.0 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3H2C3 PF17122.5 CDF33945.1 - 0.53 10.4 7.4 0.36 10.9 4.5 2.3 2 1 0 2 2 2 0 Zinc-finger Prok-RING_1 PF14446.6 CDF33945.1 - 1.7 8.6 7.5 0.18 11.8 0.9 2.3 1 1 0 2 2 2 0 Prokaryotic RING finger family 1 Vps54 PF07928.12 CDF33946.1 - 9.1e-26 90.9 0.2 2.4e-25 89.5 0.1 1.8 2 0 0 2 2 2 1 Vps54-like protein DUF2624 PF11116.8 CDF33946.1 - 0.086 13.7 0.0 0.22 12.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) PDE8 PF08629.10 CDF33946.1 - 0.13 12.3 0.1 0.35 10.9 0.1 1.8 1 0 0 1 1 1 0 PDE8 phosphodiesterase Gly_transf_sug PF04488.15 CDF33947.1 - 3.2e-07 30.9 0.1 3.2e-06 27.7 0.0 2.6 3 0 0 3 3 3 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 CDF33947.1 - 1e-05 25.1 0.0 3.6e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 CDF33947.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Uma2 PF05685.12 CDF33948.1 - 6.3e-08 32.3 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease RNA_pol_L PF01193.24 CDF33951.1 - 1.1e-06 28.0 0.0 1.3e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PhoLip_ATPase_C PF16212.5 CDF33958.1 - 2.2e-53 181.6 19.7 2.2e-53 181.6 19.7 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDF33958.1 - 3.4e-15 55.5 3.7 8.7e-15 54.2 3.7 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDF33958.1 - 4.2e-14 53.4 3.6 9.3e-11 42.4 3.9 3.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF33958.1 - 2.2e-11 43.7 0.1 1.3e-10 41.2 0.0 2.3 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDF33958.1 - 1.6e-10 40.8 0.2 1.3e-09 37.8 0.0 2.6 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDF33958.1 - 0.002 17.9 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1772 PF08592.11 CDF33958.1 - 0.028 14.7 5.1 12 6.2 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) RRM_1 PF00076.22 CDF33959.1 - 2e-49 165.3 0.2 3e-19 68.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF33959.1 - 2.9e-07 30.5 0.0 0.007 16.5 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif PHM7_cyt PF14703.6 CDF33959.1 - 0.0026 18.0 0.1 0.6 10.3 0.0 3.0 3 0 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 CDF33959.1 - 0.0032 17.0 0.0 0.71 9.5 0.0 2.7 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDF33959.1 - 0.0063 16.5 0.1 0.073 13.1 0.1 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CDF33959.1 - 0.054 13.5 0.1 1.2 9.2 0.0 2.9 3 1 0 3 3 3 0 RNA binding motif RRM_occluded PF16842.5 CDF33959.1 - 0.079 12.8 0.0 3.5 7.6 0.0 2.8 3 1 0 3 3 3 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CDF33959.1 - 0.2 11.8 0.2 21 5.3 0.0 3.1 3 0 0 3 3 3 0 Limkain b1 Lon_C PF05362.13 CDF33960.1 - 2.6e-77 259.0 0.0 4.3e-77 258.3 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CDF33960.1 - 1.1e-25 90.7 0.0 2.1e-25 89.8 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CDF33960.1 - 3.5e-23 82.5 0.0 1.5e-22 80.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 CDF33960.1 - 6.8e-08 32.8 0.0 2.2e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CDF33960.1 - 7.9e-07 29.2 0.0 1.6e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDF33960.1 - 3.5e-06 27.5 0.2 0.00026 21.4 0.0 3.0 2 2 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CDF33960.1 - 1.3e-05 25.5 0.5 0.0055 17.0 0.0 3.7 2 1 0 2 2 2 1 AAA domain ChlI PF13541.6 CDF33960.1 - 2.1e-05 24.3 0.0 4.4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 CDF33960.1 - 2.3e-05 23.5 0.0 4.6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 CDF33960.1 - 3.7e-05 23.5 0.0 0.00028 20.7 0.0 2.5 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 CDF33960.1 - 0.0013 18.6 2.9 0.12 12.3 0.0 3.0 2 1 1 3 3 3 1 NTPase AAA_3 PF07726.11 CDF33960.1 - 0.004 17.0 0.0 0.015 15.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDF33960.1 - 0.0078 16.8 0.2 0.034 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDF33960.1 - 0.026 13.7 0.1 0.052 12.7 0.1 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain SKI PF01202.22 CDF33960.1 - 0.036 14.2 0.8 0.082 13.0 0.0 2.0 2 0 0 2 2 1 0 Shikimate kinase AAA_30 PF13604.6 CDF33960.1 - 0.039 13.7 0.1 0.11 12.2 0.1 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDF33960.1 - 0.04 14.3 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 CDF33960.1 - 0.066 13.3 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDF33960.1 - 0.07 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain DUF445 PF04286.12 CDF33960.1 - 0.094 12.5 5.4 0.85 9.4 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF445) RsgA_GTPase PF03193.16 CDF33960.1 - 0.1 12.5 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 CDF33960.1 - 0.11 12.8 0.0 0.41 11.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 CDF33960.1 - 0.16 11.4 0.5 0.45 10.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 CDF33960.1 - 0.2 11.4 1.2 2 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain HIP1_clath_bdg PF16515.5 CDF33960.1 - 0.24 12.0 4.6 0.64 10.7 4.6 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CDH PF02611.15 CDF33962.1 - 0.0095 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase PRP1_N PF06424.12 CDF33966.1 - 3.4e-24 85.9 0.0 8.2e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CDF33966.1 - 3.5e-20 71.0 42.9 0.0021 18.7 0.3 13.8 8 5 6 14 14 14 8 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33966.1 - 3.3e-13 49.9 25.4 1.7e-08 34.9 1.4 9.2 9 2 2 11 11 11 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF33966.1 - 2.3e-06 27.6 3.4 18 6.0 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF33966.1 - 0.0035 17.6 6.8 7.3 7.0 0.8 5.9 4 2 1 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CDF33966.1 - 0.0083 15.3 6.5 0.42 9.7 0.0 4.4 4 2 1 5 5 5 1 NRDE-2, necessary for RNA interference FAT PF02259.23 CDF33966.1 - 0.031 13.5 3.2 1.7 7.7 0.2 2.9 2 1 0 2 2 2 0 FAT domain TPR_2 PF07719.17 CDF33966.1 - 0.11 12.6 11.8 13 6.2 0.0 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDF33966.1 - 0.37 11.1 2.9 29 5.2 0.0 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat HAT PF02184.16 CDF33966.1 - 0.5 10.4 2.8 3 7.9 0.0 3.6 3 0 0 3 3 3 0 HAT (Half-A-TPR) repeat TPR_20 PF14561.6 CDF33966.1 - 6.2 7.2 8.6 3.8 7.9 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat LPMO_10 PF03067.15 CDF33967.1 - 7.6e-06 26.7 2.4 1e-05 26.3 0.3 2.0 2 1 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading PSI_integrin PF17205.3 CDF33967.1 - 0.72 9.6 4.9 2.6 7.9 2.6 2.5 2 0 0 2 2 2 0 Integrin plexin domain Cornifin PF02389.15 CDF33968.1 - 3.4e-09 37.0 182.8 0.0004 20.6 11.4 11.7 3 2 9 12 12 12 9 Cornifin (SPRR) family FANCI_S2 PF14676.6 CDF33969.1 - 0.0088 16.4 1.0 0.096 13.0 0.1 3.2 3 0 0 3 3 3 1 FANCI solenoid 2 HEAT_2 PF13646.6 CDF33969.1 - 0.14 12.5 10.0 0.15 12.5 0.9 4.8 3 1 1 4 4 4 0 HEAT repeats HBD PF18534.1 CDF33969.1 - 0.26 11.4 2.2 36 4.6 0.0 3.8 4 0 0 4 4 4 0 Helical bundle domain CDC27 PF09507.10 CDF33970.1 - 0.22 10.9 32.4 0.3 10.4 32.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Asp-B-Hydro_N PF05279.11 CDF33970.1 - 9.8 6.2 21.6 13 5.8 21.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Spo7 PF03907.13 CDF33974.1 - 9.2e-09 35.1 1.3 1.3e-08 34.6 1.3 1.1 1 0 0 1 1 1 1 Spo7-like protein Tmemb_18A PF09771.9 CDF33974.1 - 0.00012 22.4 0.0 0.00016 22.0 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 188 LPG_synthase_TM PF03706.13 CDF33974.1 - 0.021 14.4 0.4 0.028 14.0 0.4 1.2 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region TPR_1 PF00515.28 CDF33975.1 - 1.5e-07 30.9 8.0 7.6e-05 22.4 0.8 4.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDF33975.1 - 7.4e-05 22.4 3.2 0.041 13.6 1.2 2.8 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 CDF33975.1 - 0.00071 19.8 1.1 0.062 13.7 0.2 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDF33975.1 - 0.0012 19.1 9.9 0.0051 17.1 3.4 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF33975.1 - 0.0048 17.0 6.3 11 6.5 0.5 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat SGT1 PF07093.11 CDF33975.1 - 0.02 13.4 0.0 0.034 12.6 0.0 1.2 1 0 0 1 1 1 0 SGT1 protein TPR_2 PF07719.17 CDF33975.1 - 0.056 13.6 13.6 0.14 12.3 0.1 4.2 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33975.1 - 1.1 10.3 7.0 5.3 8.1 1.6 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat DUF4407 PF14362.6 CDF33975.1 - 2.9 7.1 8.6 2.3 7.5 7.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Lant_dehydr_C PF14028.6 CDF33975.1 - 3.2 7.2 6.2 23 4.4 0.1 2.1 1 1 1 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term Oxysterol_BP PF01237.18 CDF33976.1 - 7.3e-89 298.2 0.0 1e-88 297.7 0.0 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein WD40 PF00400.32 CDF33980.1 - 4.5e-39 131.7 36.4 1.8e-06 28.6 1.3 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat TIR_2 PF13676.6 CDF33980.1 - 6e-17 62.3 0.0 1.3e-15 58.1 0.0 3.0 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF33980.1 - 4.3e-16 58.9 0.0 8.7e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF33980.1 - 8.3e-08 32.2 0.0 1.9e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF33980.1 - 9.1e-05 22.7 10.9 1.5 9.2 0.2 5.5 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 CDF33980.1 - 0.00058 20.1 0.0 0.0017 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIR-like PF10137.9 CDF33980.1 - 0.032 14.2 0.0 0.089 12.8 0.0 1.8 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain MspA PF09203.11 CDF33980.1 - 0.18 11.7 7.3 4.9 7.0 3.2 3.0 1 1 1 2 2 2 0 MspA Nup160 PF11715.8 CDF33980.1 - 0.76 8.3 14.1 14 4.2 0.1 5.7 4 2 1 6 6 6 0 Nucleoporin Nup120/160 Y_phosphatase2 PF03162.13 CDF33982.1 - 2.8e-39 134.3 0.0 3.5e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family MEKHLA PF08670.11 CDF33982.1 - 0.0075 16.2 0.1 0.82 9.6 0.0 2.1 2 0 0 2 2 2 2 MEKHLA domain CN_hydrolase PF00795.22 CDF33983.1 - 7.2e-33 114.0 0.0 1e-32 113.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 CDF33983.1 - 1.2e-25 90.1 0.0 2.7e-25 88.9 0.0 1.5 1 1 0 1 1 1 1 NAD synthase CK_II_beta PF01214.18 CDF33983.1 - 0.18 11.6 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Casein kinase II regulatory subunit WD40 PF00400.32 CDF33984.1 - 4.3e-62 204.6 51.6 1e-05 26.2 0.5 11.5 11 0 0 11 11 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF33984.1 - 4.3e-09 36.5 15.5 2.4 8.5 0.1 8.6 1 1 10 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF33984.1 - 1.4e-06 27.2 15.9 9.1 4.8 0.0 10.2 8 3 1 11 11 11 2 Nucleoporin Nup120/160 NB-ARC PF00931.22 CDF33984.1 - 0.02 14.1 0.0 0.072 12.3 0.0 1.9 1 0 0 1 1 1 0 NB-ARC domain APAF1_C PF17908.1 CDF33984.1 - 0.22 11.5 0.0 0.43 10.6 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain PPR_2 PF13041.6 CDF33985.1 - 1.5e-33 114.7 0.3 1.6e-17 63.4 0.1 4.2 2 1 2 4 4 4 4 PPR repeat family PPR PF01535.20 CDF33985.1 - 4.9e-31 104.8 0.3 1.2e-10 40.9 0.1 4.2 4 0 0 4 4 4 4 PPR repeat PPR_1 PF12854.7 CDF33985.1 - 6.8e-26 89.7 0.1 1.6e-10 40.5 0.0 4.0 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 CDF33985.1 - 1.9e-18 66.2 0.0 1.3e-08 34.7 0.0 3.3 2 1 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 CDF33985.1 - 5.8e-12 45.4 0.0 5.9e-08 32.3 0.0 2.2 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_7 PF13176.6 CDF33985.1 - 1.4e-06 27.9 0.2 3.3 7.9 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF33985.1 - 2.6e-06 27.8 7.4 0.48 11.4 0.0 4.4 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF33985.1 - 0.0039 17.7 3.7 1.4 9.5 0.1 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF33985.1 - 0.0048 16.9 2.0 12 6.4 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF33985.1 - 0.0073 16.6 0.6 1.8 8.9 0.1 3.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF33985.1 - 0.031 14.5 0.3 6.7 7.2 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat MNE1 PF13762.6 CDF33985.1 - 0.041 13.9 0.0 0.61 10.1 0.0 2.3 1 1 1 2 2 2 0 Mitochondrial splicing apparatus component RPN7 PF10602.9 CDF33985.1 - 0.046 13.4 0.3 1.6 8.5 0.1 2.7 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_10 PF13374.6 CDF33985.1 - 0.053 13.4 3.8 11 6.1 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP13 PF12921.7 CDF33985.1 - 0.06 13.2 0.0 21 5.0 0.0 2.9 1 1 2 3 3 3 0 Mitochondrial ATPase expression Coatomer_E PF04733.14 CDF33985.1 - 0.077 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_1 PF00515.28 CDF33985.1 - 0.11 12.4 2.2 13 5.8 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF33985.1 - 0.7 10.6 6.0 1.2e+02 3.4 0.1 4.2 4 1 0 4 4 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDF33985.1 - 1.9 9.3 8.1 19 6.3 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.32 CDF33986.1 - 5.1e-37 125.2 30.0 1.9e-05 25.3 0.7 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat TIR_2 PF13676.6 CDF33986.1 - 2.1e-17 63.8 0.0 4.8e-16 59.4 0.0 3.0 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF33986.1 - 6e-16 58.4 0.0 1.5e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF33986.1 - 2.3e-08 34.0 0.0 5e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF33986.1 - 9.4e-07 29.0 7.7 1.7 9.0 0.1 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 CDF33986.1 - 0.0019 18.5 0.0 0.0052 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIR-like PF10137.9 CDF33986.1 - 0.02 14.8 0.0 0.075 13.0 0.0 2.0 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Nup160 PF11715.8 CDF33986.1 - 0.033 12.8 10.9 25 3.3 0.1 6.4 3 2 4 7 7 7 0 Nucleoporin Nup120/160 RT_RNaseH PF17917.1 CDF33987.1 - 0.0024 18.1 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase GST_C_3 PF14497.6 CDF33989.1 - 2.2e-05 24.6 0.0 3.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDF33989.1 - 7.5e-05 23.1 0.0 0.00013 22.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF33989.1 - 0.00023 21.4 0.0 0.0004 20.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDF33989.1 - 0.00024 21.3 0.0 0.00043 20.4 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDF33989.1 - 0.0018 18.2 0.0 0.0045 17.0 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDF33989.1 - 0.035 14.4 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF3470 PF11953.8 CDF33989.1 - 0.19 11.8 0.2 0.31 11.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3470) FANCI_S3 PF14677.6 CDF33989.1 - 0.23 11.2 0.0 0.3 10.8 0.0 1.1 1 0 0 1 1 1 0 FANCI solenoid 3 YjhX_toxin PF09857.9 CDF33990.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative toxin of bacterial toxin-antitoxin pair SH2_2 PF14633.6 CDF33994.1 - 0.38 10.1 6.7 0.66 9.3 6.7 1.4 1 0 0 1 1 1 0 SH2 domain Ribosomal_L44 PF00935.19 CDF33995.1 - 1.4e-35 121.5 10.7 2.1e-35 121.0 10.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Cathelicidins PF00666.17 CDF33995.1 - 0.0093 16.3 1.4 0.018 15.4 1.4 1.4 1 0 0 1 1 1 1 Cathelicidin DnaJ PF00226.31 CDF33996.1 - 5e-20 71.4 0.1 1e-19 70.4 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 CDF33996.1 - 9.6e-09 34.8 0.0 4.5e-08 32.6 0.0 2.1 1 1 0 1 1 1 1 Sec63 Brl domain LPG_synthase_TM PF03706.13 CDF33996.1 - 0.036 13.6 0.9 2.1 7.8 0.1 2.1 2 0 0 2 2 2 0 Lysylphosphatidylglycerol synthase TM region DUF3593 PF12159.8 CDF33996.1 - 0.052 13.6 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3593) PetL PF05115.14 CDF33996.1 - 0.54 10.3 3.2 1.1 9.3 3.2 1.5 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit VI (PetL) Aminotran_1_2 PF00155.21 CDF33998.1 - 3.5e-61 207.4 0.0 4.1e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.25 CDF33999.1 - 2.4e-71 240.2 0.0 3.5e-71 239.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF33999.1 - 7.4e-50 169.6 0.0 1.1e-49 169.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Arm PF00514.23 CDF33999.1 - 2e-14 53.0 2.6 0.001 19.0 0.1 6.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Kdo PF06293.14 CDF33999.1 - 2.2e-05 23.9 0.0 5.5e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF33999.1 - 0.00047 19.2 0.0 0.00075 18.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF33999.1 - 0.015 14.6 0.0 0.052 12.8 0.0 1.8 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 CDF33999.1 - 0.019 14.9 2.8 0.18 11.7 0.0 3.2 2 1 0 3 3 3 0 Phosphotransferase enzyme family Atx10homo_assoc PF09759.9 CDF33999.1 - 0.072 13.1 0.0 11 6.1 0.0 3.3 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 CDF33999.1 - 0.12 12.9 0.5 1.3 9.6 0.4 3.0 2 0 0 2 2 2 0 HEAT-like repeat Seadorna_VP7 PF07387.11 CDF33999.1 - 0.16 11.0 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 TPR_2 PF07719.17 CDF34000.1 - 3e-26 89.4 22.7 0.0053 16.8 0.2 9.6 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 CDF34000.1 - 2.4e-20 71.4 16.3 0.0041 16.9 0.0 8.9 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 CDF34000.1 - 3.3e-20 72.2 27.5 2.1e-05 24.7 1.1 7.4 5 2 2 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 CDF34000.1 - 1.5e-15 56.0 17.9 0.0022 18.0 0.1 8.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF34000.1 - 3.5e-14 52.1 11.3 0.005 17.1 0.0 8.9 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDF34000.1 - 4.9e-12 46.3 24.0 0.00027 21.5 0.0 7.4 6 2 1 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF34000.1 - 1.3e-11 44.8 15.2 0.0086 16.6 0.1 6.6 5 1 1 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF34000.1 - 8.8e-11 41.3 7.3 0.0099 15.5 0.4 7.1 7 1 1 8 8 8 3 TPR repeat TPR_9 PF13371.6 CDF34000.1 - 2.7e-09 37.0 6.8 0.024 14.8 0.1 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDF34000.1 - 4.4e-07 30.1 6.7 1.4 9.7 0.0 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF34000.1 - 2.7e-05 24.6 18.1 0.33 11.9 1.3 9.0 5 4 6 11 11 11 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF34000.1 - 9e-05 22.2 11.2 0.089 12.9 0.1 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_20 PF14561.6 CDF34000.1 - 0.00026 21.2 5.1 0.13 12.6 0.4 4.8 4 1 1 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 CDF34000.1 - 0.00093 18.7 2.9 3.4 7.0 0.1 3.8 3 2 1 4 4 4 2 Coatomer epsilon subunit DUF4810 PF16068.5 CDF34000.1 - 0.0018 18.8 2.0 1.1 9.9 0.0 5.2 6 0 0 6 6 6 1 Domain of unknown function (DUF4810) TPR_10 PF13374.6 CDF34000.1 - 0.0082 16.0 37.1 0.045 13.6 0.4 9.1 11 0 0 11 11 10 3 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CDF34000.1 - 0.13 12.2 1.5 8 6.3 0.4 2.6 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal ANAPC3 PF12895.7 CDF34000.1 - 1.6 9.0 13.1 8.7 6.7 0.1 5.1 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 CCD48 PF15799.5 CDF34002.1 - 0.0034 15.8 5.2 0.0034 15.8 5.2 1.9 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 48 TssO PF17561.2 CDF34002.1 - 0.87 9.7 10.0 4.2 7.5 0.0 3.1 3 0 0 3 3 3 0 Type VI secretion system, TssO HEAT_2 PF13646.6 CDF34004.1 - 3.2e-10 40.2 9.6 0.011 16.0 0.0 4.8 4 0 0 4 4 4 3 HEAT repeats HEAT PF02985.22 CDF34004.1 - 1.5e-07 31.0 14.2 0.026 14.7 0.0 8.7 11 0 0 11 11 11 2 HEAT repeat Cnd1 PF12717.7 CDF34004.1 - 0.00027 21.0 0.1 0.0069 16.4 0.0 2.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CDF34004.1 - 0.0045 17.5 0.6 9.8 6.8 0.0 4.4 3 0 0 3 3 3 1 HEAT-like repeat RAB3GAP2_N PF14655.6 CDF34005.1 - 0.07 12.4 0.5 0.1 11.9 0.5 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Kinesin PF00225.23 CDF34007.1 - 6e-75 252.2 0.9 2.4e-74 250.3 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CDF34007.1 - 0.00027 20.9 0.0 0.0012 18.8 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Spc7 PF08317.11 CDF34007.1 - 0.0085 15.0 5.1 0.16 10.9 3.9 2.6 3 0 0 3 3 3 1 Spc7 kinetochore protein Sec34 PF04136.15 CDF34007.1 - 0.016 15.1 2.0 0.023 14.6 0.8 1.9 2 0 0 2 2 2 0 Sec34-like family YabA PF06156.13 CDF34007.1 - 0.02 15.5 0.7 0.24 12.1 0.9 2.7 3 0 0 3 3 2 0 Initiation control protein YabA PI3K_P85_iSH2 PF16454.5 CDF34007.1 - 0.031 13.9 0.7 0.56 9.8 0.3 2.4 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 CDF34007.1 - 0.032 14.3 4.4 7.3 6.7 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) DUF4515 PF14988.6 CDF34007.1 - 0.055 13.3 4.3 0.053 13.4 2.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4515) GAS PF13851.6 CDF34007.1 - 0.06 12.7 9.7 0.3 10.4 6.3 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 CDF34007.1 - 0.071 13.1 5.9 3 7.9 3.5 3.3 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 CDF34007.1 - 0.086 13.3 10.9 0.44 11.0 10.8 2.1 1 1 0 1 1 1 0 Fez1 TSC22 PF01166.18 CDF34007.1 - 0.091 13.1 2.3 0.86 10.0 1.4 3.1 3 0 0 3 3 3 0 TSC-22/dip/bun family PRKG1_interact PF15898.5 CDF34007.1 - 0.095 13.6 7.6 29 5.6 0.0 3.2 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Tup_N PF08581.10 CDF34007.1 - 0.19 12.1 2.9 21 5.5 0.0 2.7 2 0 0 2 2 2 0 Tup N-terminal Atg14 PF10186.9 CDF34007.1 - 0.2 10.7 2.6 0.38 9.8 2.6 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EzrA PF06160.12 CDF34007.1 - 0.21 9.7 4.8 0.14 10.3 1.6 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA SOGA PF11365.8 CDF34007.1 - 0.22 12.7 4.3 0.24 12.5 2.1 2.3 2 0 0 2 2 1 0 Protein SOGA GrpE PF01025.19 CDF34007.1 - 0.28 10.8 7.2 0.068 12.8 1.8 2.3 2 0 0 2 2 2 0 GrpE Csm1_N PF18504.1 CDF34007.1 - 0.59 10.5 4.2 1.1 9.6 0.8 3.0 2 1 1 3 3 2 0 Csm1 N-terminal domain SYCE1 PF15233.6 CDF34007.1 - 0.6 10.2 7.8 0.31 11.1 5.2 1.8 2 0 0 2 2 1 0 Synaptonemal complex central element protein 1 BRE1 PF08647.11 CDF34007.1 - 0.95 9.6 5.3 2.5 8.2 2.8 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DHR10 PF18595.1 CDF34007.1 - 1.4 9.0 13.8 0.41 10.7 7.3 3.0 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain UPF0242 PF06785.11 CDF34007.1 - 2.3 8.3 5.9 0.52 10.4 2.2 1.8 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus Borrelia_P83 PF05262.11 CDF34007.1 - 2.5 6.5 10.0 0.18 10.2 0.1 2.3 2 1 0 2 2 2 0 Borrelia P83/100 protein DivIC PF04977.15 CDF34007.1 - 2.8 7.8 6.5 15 5.5 0.9 3.3 4 0 0 4 4 3 0 Septum formation initiator EMP24_GP25L PF01105.24 CDF34007.1 - 3 7.7 4.7 5.9 6.8 2.2 2.5 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD ATG16 PF08614.11 CDF34007.1 - 5.7 7.1 14.2 0.21 11.8 7.3 2.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Pkinase PF00069.25 CDF34008.1 - 1.4e-50 172.2 0.0 1.8e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34008.1 - 1.4e-21 77.0 0.0 9.9e-15 54.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDF34008.1 - 0.00045 19.6 0.0 0.02 14.2 0.0 2.7 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 CDF34008.1 - 0.19 11.3 0.0 12 5.4 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-CCCH PF00642.24 CDF34009.1 - 0.046 13.6 0.5 0.076 12.9 0.5 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) IQCJ-SCHIP1 PF15157.6 CDF34009.1 - 0.13 12.1 0.3 0.17 11.8 0.3 1.2 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif CDH PF02611.15 CDF34012.1 - 0.0096 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase EMC3_TMCO1 PF01956.16 CDF34013.1 - 3.8e-06 26.7 0.7 5.3e-06 26.3 0.2 1.4 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like D_CNTX PF17492.2 CDF34016.1 - 2.7 8.2 6.6 4.5 7.5 0.6 2.7 2 1 0 2 2 2 0 Delta Ctenitoxins Sel1 PF08238.12 CDF34017.1 - 1e-30 105.5 1.7 5.7e-05 23.6 0.0 6.1 6 0 0 6 6 6 5 Sel1 repeat TPR_16 PF13432.6 CDF34017.1 - 2.9e-10 40.6 10.4 0.034 14.8 3.7 5.4 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDF34017.1 - 2.2e-08 34.2 2.4 2.4 9.0 0.0 6.5 6 2 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF34017.1 - 1.3e-06 28.0 8.9 2.1 8.6 0.0 6.2 1 1 4 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF34017.1 - 1.1e-05 25.8 13.7 0.58 11.1 0.3 6.0 3 3 3 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDF34017.1 - 2.6e-05 24.3 0.1 12 6.6 0.0 6.1 6 3 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF34017.1 - 0.0013 19.2 7.2 12 6.5 0.1 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat NSF PF02071.20 CDF34017.1 - 0.0044 17.5 0.6 1.1e+02 4.3 0.0 5.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.17 CDF34017.1 - 0.0083 16.2 5.9 66 4.0 0.1 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat RIC1 PF07064.13 CDF34017.1 - 0.01 15.2 0.0 9.6 5.5 0.0 2.9 3 0 0 3 3 3 0 RIC1 TPR_1 PF00515.28 CDF34017.1 - 0.1 12.5 4.3 33 4.5 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat FIST_C PF10442.9 CDF34017.1 - 0.19 11.7 1.5 1 9.3 1.5 2.3 1 1 0 1 1 1 0 FIST C domain ALF PF03752.13 CDF34017.1 - 0.23 11.5 6.5 1.4 8.9 0.0 4.1 4 0 0 4 4 4 0 Short repeats of unknown function Paramyx_P_V_C PF03210.13 CDF34018.1 - 0.07 12.9 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal p450 PF00067.22 CDF34019.1 - 3.3e-60 204.2 0.0 4e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CDF34021.1 - 2.5e-50 171.6 0.0 3.4e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF349 PF03993.12 CDF34021.1 - 0.0015 18.8 1.1 0.0092 16.3 1.0 2.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF349) DUF4519 PF15012.6 CDF34021.1 - 0.23 11.6 1.4 0.6 10.3 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) p450 PF00067.22 CDF34023.1 - 2.8e-53 181.3 0.0 3.7e-53 180.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GSDH PF07995.11 CDF34024.1 - 1.3e-25 90.4 0.0 3.1e-25 89.2 0.0 1.6 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase NHL PF01436.21 CDF34024.1 - 0.027 14.5 0.0 0.079 13.0 0.0 1.8 1 0 0 1 1 1 0 NHL repeat DUF839 PF05787.13 CDF34024.1 - 0.028 13.6 0.0 0.041 13.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) Cob_adeno_trans PF01923.18 CDF34025.1 - 1.2e-57 194.7 0.0 1.4e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 Cobalamin adenosyltransferase ABC_tran PF00005.27 CDF34030.1 - 3.4e-27 95.6 0.0 4.8e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CDF34030.1 - 1.4e-25 89.9 14.0 1.4e-25 89.9 14.0 1.4 1 1 0 1 1 1 1 ABC-2 type transporter AAA_16 PF13191.6 CDF34030.1 - 0.0013 19.1 0.1 0.0024 18.3 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDF34030.1 - 0.0053 16.7 0.0 0.0091 15.9 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 CDF34030.1 - 0.017 14.6 0.2 6.1 6.2 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 CDF34030.1 - 0.018 14.8 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 CDF34030.1 - 0.025 14.8 0.0 0.065 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDF34030.1 - 0.039 13.8 0.5 0.45 10.3 0.1 2.4 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 CDF34030.1 - 0.05 13.8 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDF34030.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 CDF34030.1 - 0.062 12.9 0.0 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CDF34030.1 - 0.14 12.4 0.0 0.37 11.0 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 CDF34030.1 - 0.18 11.7 0.0 0.68 9.8 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 CDF34030.1 - 0.19 11.4 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDF34030.1 - 0.19 11.7 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CBS PF00571.28 CDF34032.1 - 6.7e-21 74.5 0.1 2.8e-10 40.5 0.0 2.4 2 0 0 2 2 2 2 CBS domain DHHA1 PF02272.19 CDF34032.1 - 7.5e-05 23.2 0.7 0.00024 21.5 0.3 1.9 2 0 0 2 2 2 1 DHHA1 domain OMPdecase PF00215.24 CDF34033.1 - 6.8e-73 245.0 0.1 1e-72 244.4 0.1 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 CDF34033.1 - 4.3e-10 39.3 0.1 8.5e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pkinase_Tyr PF07714.17 CDF34034.1 - 1.2e-52 178.7 0.0 1.8e-50 171.7 0.0 3.0 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.25 CDF34034.1 - 1.6e-46 158.8 4.3 6.2e-46 156.9 0.0 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_fungal PF17667.1 CDF34034.1 - 8e-05 21.6 0.3 0.00037 19.4 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CDF34034.1 - 0.02 14.3 0.2 0.052 12.9 0.2 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S49_N PF08496.10 CDF34034.1 - 0.53 10.3 4.3 1 9.4 4.3 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rtf2 PF04641.12 CDF34034.1 - 1.9 7.7 10.8 0.074 12.4 4.0 2.0 3 0 0 3 3 3 0 Rtf2 RING-finger Med19 PF10278.9 CDF34034.1 - 2.4 8.0 9.1 4.5 7.2 9.1 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Cytochrom_C PF00034.21 CDF34034.1 - 4.2 8.6 9.9 0.48 11.6 2.5 2.9 2 0 0 2 2 2 0 Cytochrome c SR-25 PF10500.9 CDF34034.1 - 4.4 6.8 17.7 3.5 7.2 8.0 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DDE_Tnp_4 PF13359.6 CDF34036.1 - 3.2e-23 82.1 0.0 4e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyoxalase PF00903.25 CDF34038.1 - 1.9e-05 24.8 0.0 2.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Cation_ATPase_C PF00689.21 CDF34039.1 - 4.6e-44 150.3 2.3 9.8e-44 149.2 0.4 2.5 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CDF34039.1 - 1.5e-40 138.6 0.4 1.5e-40 138.6 0.4 2.1 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CDF34039.1 - 3.3e-22 79.8 0.0 1.2e-21 78.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF34039.1 - 3.6e-18 65.4 0.0 8.5e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDF34039.1 - 7.4e-10 38.4 0.0 1.9e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDF34039.1 - 2.5e-07 30.7 0.3 0.0081 15.9 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF34039.1 - 0.00042 20.8 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SAC3_GANP PF03399.16 CDF34040.1 - 3.4e-23 82.5 0.6 1.3e-21 77.2 0.6 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CDF34040.1 - 0.055 13.5 0.3 0.13 12.2 0.3 1.7 1 1 0 1 1 1 0 CSN8/PSMD8/EIF3K family Globin PF00042.22 CDF34041.1 - 3.5e-10 40.4 0.1 2.3e-09 37.8 0.1 2.0 1 1 0 1 1 1 1 Globin Branch PF02485.21 CDF34042.1 - 2.6e-34 118.8 0.3 3.7e-34 118.3 0.3 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme 3HCDH_N PF02737.18 CDF34042.1 - 0.029 14.3 0.1 0.049 13.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 CDF34043.1 - 3.8e-69 233.0 0.0 5e-69 232.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34043.1 - 2.5e-38 131.8 0.0 3.3e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34043.1 - 4.9e-08 32.6 0.0 2.5e-05 23.8 0.0 2.3 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.22 CDF34043.1 - 3.3e-07 30.1 0.3 5.5e-07 29.4 0.3 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDF34043.1 - 3.9e-06 27.0 1.0 0.05 13.5 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 CDF34043.1 - 0.0012 18.5 0.0 0.0031 17.2 0.0 1.8 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDF34043.1 - 0.0012 18.2 0.2 0.0025 17.2 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF34043.1 - 0.021 13.8 0.1 0.033 13.2 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 CDF34043.1 - 0.078 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 tRNA-synt_1d PF00750.19 CDF34044.1 - 7.9e-121 403.2 0.0 1.8e-120 402.1 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CDF34044.1 - 3.1e-26 91.9 0.0 7.2e-26 90.7 0.0 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CDF34044.1 - 1.4e-20 73.6 0.0 3.5e-20 72.4 0.0 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1g PF09334.11 CDF34044.1 - 0.084 11.6 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CDF34044.1 - 0.11 11.9 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Atx10homo_assoc PF09759.9 CDF34047.1 - 2.2e-05 24.4 0.0 0.0016 18.4 0.0 3.1 2 1 1 3 3 3 1 Spinocerebellar ataxia type 10 protein domain zf-C2H2 PF00096.26 CDF34051.1 - 1.8e-07 31.2 11.0 1.6e-05 25.1 3.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF34051.1 - 6.9e-07 29.4 1.1 6.9e-07 29.4 1.1 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF34051.1 - 0.022 15.6 2.2 0.022 15.6 2.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger EF-hand_7 PF13499.6 CDF34052.1 - 0.0014 19.0 0.0 0.006 17.0 0.0 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CDF34052.1 - 0.025 14.5 0.1 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain DUF4127 PF13552.6 CDF34053.1 - 0.04 12.5 0.0 0.076 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) IBR PF01485.21 CDF34053.1 - 0.068 13.4 4.1 0.2 11.9 4.1 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CEBP_ZZ PF16366.5 CDF34053.1 - 0.094 13.0 1.6 0.23 11.7 1.6 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain APH PF01636.23 CDF34056.1 - 2.8e-07 30.7 0.1 4.6e-07 30.0 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF34056.1 - 0.00012 21.7 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 CDF34056.1 - 0.00019 20.9 0.0 0.00048 19.5 0.0 1.6 1 1 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 CDF34056.1 - 0.11 11.3 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 CDF34058.1 - 6.5e-22 78.2 0.0 1.1e-21 77.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDF34058.1 - 1.3e-07 30.7 0.0 1.6e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 CDF34058.1 - 3.8e-07 29.7 0.0 6.5e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF34058.1 - 7.7e-05 22.7 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF34058.1 - 0.003 16.9 0.1 0.0062 15.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF16 PF01519.16 CDF34058.1 - 0.031 14.7 0.8 0.088 13.3 0.8 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF948 PF06103.11 CDF34058.1 - 0.058 13.7 0.9 0.11 12.7 0.9 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CCDC144C PF14915.6 CDF34058.1 - 0.13 11.4 2.0 0.3 10.2 2.0 1.6 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region CotH PF08757.11 CDF34059.1 - 2.1e-28 99.8 6.1 3.2e-28 99.2 6.1 1.2 1 0 0 1 1 1 1 CotH kinase protein Metallophos PF00149.28 CDF34060.1 - 1.3e-37 130.3 0.0 2e-37 129.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDF34060.1 - 0.096 13.1 0.1 0.28 11.6 0.0 1.8 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain Cupin_8 PF13621.6 CDF34063.1 - 7.7e-40 137.2 0.0 1e-39 136.8 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain DEAD PF00270.29 CDF34065.1 - 5e-44 150.2 0.0 8.5e-44 149.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF34065.1 - 1.4e-21 77.0 0.1 4.8e-21 75.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SPRY PF00622.28 CDF34065.1 - 4.7e-06 26.7 0.0 9.7e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 SPRY domain PAPS_reduct PF01507.19 CDF34066.1 - 1.3e-44 152.3 0.0 1.8e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Glutaredoxin PF00462.24 CDF34066.1 - 6.1e-17 61.6 0.2 2.6e-16 59.6 0.0 2.2 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin_2 PF13098.6 CDF34066.1 - 0.021 15.3 0.4 0.043 14.3 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin-like domain HHH_9 PF17674.1 CDF34066.1 - 0.084 13.8 0.0 0.32 11.9 0.0 1.9 2 0 0 2 2 2 0 HHH domain Pox_MCEL PF03291.16 CDF34071.1 - 1.8e-81 273.9 0.1 2.5e-81 273.4 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 CDF34071.1 - 6.6e-12 46.0 0.0 1.3e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF34071.1 - 2.2e-07 31.5 0.0 5.4e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF34071.1 - 6.8e-07 29.8 0.0 1.3e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF34071.1 - 2e-05 24.4 0.0 3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF34071.1 - 5.2e-05 23.1 0.0 8.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 CDF34071.1 - 0.0047 16.5 0.0 0.007 15.9 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Ubie_methyltran PF01209.18 CDF34071.1 - 0.012 14.9 0.0 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 CDF34071.1 - 0.03 13.5 0.0 0.064 12.4 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF4106 PF13388.6 CDF34071.1 - 1.2 8.2 3.8 2.1 7.5 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) PP2C PF00481.21 CDF34072.1 - 2e-08 34.2 0.0 2.2e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDF34072.1 - 0.039 13.9 0.1 0.05 13.5 0.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Peptidase_C14 PF00656.22 CDF34074.1 - 1.4e-35 123.4 0.0 1.7e-35 123.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain YlbD_coat PF14071.6 CDF34076.1 - 0.038 14.3 0.4 0.047 13.9 0.4 1.1 1 0 0 1 1 1 0 Putative coat protein Phage_GPD PF05954.11 CDF34076.1 - 0.073 12.3 0.1 0.09 12.1 0.1 1.0 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) zf-C2H2_jaz PF12171.8 CDF34077.1 - 4.6e-06 26.8 0.9 7.4e-06 26.1 0.9 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDF34077.1 - 0.0016 18.8 2.1 0.0024 18.2 2.1 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDF34077.1 - 0.0094 16.3 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) ANAPC_CDC26 PF10471.9 CDF34077.1 - 4.2 8.3 10.6 0.18 12.7 0.7 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Peptidase_S9_N PF02897.15 CDF34078.1 - 5e-113 378.0 2.2 7.3e-113 377.5 2.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CDF34078.1 - 1.3e-55 188.1 0.0 2.3e-55 187.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family CAF1C_H4-bd PF12265.8 CDF34078.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex Tyr-DNA_phospho PF06087.12 CDF34084.1 - 5.9e-83 279.1 0.0 7.9e-83 278.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase SGS PF05002.15 CDF34084.1 - 0.11 12.7 0.0 18 5.5 0.0 2.6 2 0 0 2 2 2 0 SGS domain VKOR PF07884.14 CDF34086.1 - 1.1e-26 93.4 8.6 2.3e-26 92.4 8.6 1.5 1 0 0 1 1 1 1 Vitamin K epoxide reductase family CLP_protease PF00574.23 CDF34087.1 - 8.6e-62 208.3 0.0 1.1e-61 207.9 0.0 1.0 1 0 0 1 1 1 1 Clp protease Rtt102p PF09510.10 CDF34088.1 - 3.3 7.9 5.7 2.5 8.3 0.8 2.5 2 1 1 3 3 3 0 Rtt102p-like transcription regulator protein DBD_Tnp_Mut PF03108.15 CDF34089.1 - 0.0022 17.9 0.1 0.0028 17.6 0.1 1.2 1 0 0 1 1 1 1 MuDR family transposase Methyltransf_11 PF08241.12 CDF34090.1 - 1.2e-16 61.1 0.0 2e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF34090.1 - 7.2e-15 55.5 0.0 1.3e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF34090.1 - 4.1e-08 33.2 0.0 5.1e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF34090.1 - 3.8e-07 30.8 0.0 6.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF34090.1 - 7.8e-06 25.8 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF34090.1 - 0.00044 19.7 0.0 0.0007 19.0 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 CDF34090.1 - 0.00069 18.6 0.0 0.00084 18.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 CDF34090.1 - 0.015 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 CDF34090.1 - 0.046 13.3 0.0 0.079 12.5 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 CDF34090.1 - 0.16 11.7 0.0 0.31 10.8 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DAP3 PF10236.9 CDF34091.1 - 2e-18 66.6 0.0 4.3e-18 65.5 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CDF34091.1 - 7e-07 29.8 0.0 2.7e-06 27.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA-ATPase_like PF09820.9 CDF34091.1 - 0.00049 19.6 0.0 0.00071 19.1 0.0 1.3 1 0 0 1 1 1 1 Predicted AAA-ATPase AAA_22 PF13401.6 CDF34091.1 - 0.00051 20.3 0.0 0.14 12.4 0.0 2.9 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF34091.1 - 0.062 13.2 0.5 2.5 8.0 0.0 2.4 2 1 0 2 2 2 0 NACHT domain AAA_35 PF14516.6 CDF34091.1 - 0.083 11.7 0.0 1.7 7.4 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA PF00004.29 CDF34091.1 - 0.11 13.0 0.0 1.4 9.4 0.0 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CDF34091.1 - 0.13 11.5 0.0 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 CDF34091.1 - 0.15 12.0 0.0 0.64 9.9 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CDF34091.1 - 0.15 12.0 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) HSP70 PF00012.20 CDF34098.1 - 1.8e-36 125.5 0.3 5e-27 94.4 0.1 2.1 1 1 1 2 2 2 2 Hsp70 protein zf-NOSIP PF15906.5 CDF34099.1 - 4.8e-17 61.9 0.0 1.1e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 CDF34099.1 - 1.1e-06 28.3 5.0 0.0042 16.5 0.2 3.1 2 2 2 4 4 4 2 Rtf2 RING-finger U-box PF04564.15 CDF34099.1 - 4.6e-05 23.5 0.8 0.0039 17.3 0.0 3.0 3 1 0 3 3 3 1 U-box domain zf-C3HC4_4 PF15227.6 CDF34099.1 - 0.0077 16.4 1.4 0.015 15.4 1.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Elf1 PF05129.13 CDF34099.1 - 0.12 12.4 0.5 0.36 10.9 0.5 1.8 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-C3HC4_3 PF13920.6 CDF34099.1 - 0.13 12.1 4.0 0.12 12.3 0.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 CDF34099.1 - 0.25 11.4 1.0 0.52 10.4 1.0 1.6 1 0 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1 PF03811.13 CDF34099.1 - 0.54 10.0 2.5 4.2 7.2 0.5 2.7 2 0 0 2 2 2 0 InsA N-terminal domain Aminotran_5 PF00266.19 CDF34100.1 - 1.1e-10 41.0 0.0 1.8e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V TraK PF06586.11 CDF34100.1 - 0.2 11.3 0.0 0.31 10.7 0.0 1.2 1 0 0 1 1 1 0 TraK protein NIF PF03031.18 CDF34102.1 - 6.4e-43 146.2 0.0 8.3e-43 145.8 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 CDF34103.1 - 1.6e-07 30.9 0.0 3.2e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family FKBP_C PF00254.28 CDF34103.1 - 3e-06 27.4 0.0 6.5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 CDF34103.1 - 0.00016 22.6 1.9 0.00052 20.9 0.0 2.6 3 1 0 3 3 3 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Rad60-SLD PF11976.8 CDF34103.1 - 0.00093 19.0 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 CDF34103.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain STI1 PF17830.1 CDF34103.1 - 0.16 11.9 4.2 7.8 6.5 0.7 3.0 2 1 1 3 3 3 0 STI1 domain DUF1631 PF07793.11 CDF34103.1 - 0.65 8.4 6.5 0.97 7.8 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) HEAT PF02985.22 CDF34104.1 - 3e-38 126.5 27.1 6.9e-05 22.8 0.0 14.0 14 0 0 14 14 14 9 HEAT repeat HEAT_2 PF13646.6 CDF34104.1 - 1.2e-28 99.3 17.9 4.7e-07 30.1 0.3 7.7 4 3 4 8 8 8 7 HEAT repeats Vac14_Fab1_bd PF12755.7 CDF34104.1 - 1.2e-13 51.5 0.2 0.00011 22.8 0.0 6.9 2 2 5 7 7 7 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 CDF34104.1 - 1e-06 28.5 0.1 0.39 10.2 0.1 4.0 1 1 2 3 3 3 2 CLASP N terminal HEAT_EZ PF13513.6 CDF34104.1 - 1.9e-06 28.2 20.9 0.00046 20.6 0.1 8.4 6 4 3 9 9 9 1 HEAT-like repeat Cnd1 PF12717.7 CDF34104.1 - 3e-06 27.4 8.7 0.078 13.0 1.1 4.5 4 1 2 6 6 6 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDF34104.1 - 8.3e-06 24.6 10.4 0.072 11.6 0.0 4.0 3 1 0 5 5 5 3 Adaptin N terminal region Cohesin_HEAT PF12765.7 CDF34104.1 - 2.4e-05 24.5 0.1 4 7.8 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion Ecm29 PF13001.7 CDF34104.1 - 0.019 13.7 0.3 0.19 10.3 0.0 2.7 4 0 0 4 4 4 0 Proteasome stabiliser API5 PF05918.11 CDF34104.1 - 0.027 13.3 0.3 3.7 6.2 0.1 3.2 2 1 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) HNH_4 PF13395.6 CDF34104.1 - 0.076 12.9 0.0 3.8 7.5 0.0 2.5 2 0 0 2 2 2 0 HNH endonuclease RICTOR_V PF14668.6 CDF34104.1 - 0.086 13.1 0.0 3.6 7.9 0.0 3.5 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 Zn_peptidase_2 PF04298.12 CDF34104.1 - 0.094 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase IFRD PF05004.13 CDF34104.1 - 0.13 11.3 4.6 1.6 7.8 0.0 3.7 3 2 1 4 4 4 0 Interferon-related developmental regulator (IFRD) HTH_26 PF13443.6 CDF34104.1 - 0.15 12.5 0.1 1.7 9.1 0.0 2.5 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Arm PF00514.23 CDF34104.1 - 1.5 9.0 6.8 1.9 8.6 0.0 4.3 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat FAD_binding_4 PF01565.23 CDF34105.1 - 3e-11 43.2 0.1 4.5e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain RT_RNaseH_2 PF17919.1 CDF34106.1 - 5.9e-14 51.9 0.0 8.7e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF34106.1 - 0.00027 20.5 0.0 0.00041 19.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CDF34106.1 - 0.00083 19.6 0.0 0.0014 18.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase ThiF PF00899.21 CDF34107.1 - 8.3e-66 221.8 0.0 2.2e-65 220.4 0.0 1.6 1 1 1 2 2 2 1 ThiF family UAE_UbL PF14732.6 CDF34107.1 - 1.7e-14 54.2 0.6 3.5e-14 53.1 0.6 1.6 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 CDF34107.1 - 5.5e-07 29.8 0.0 3.9e-05 23.7 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 CDF34107.1 - 1.4e-06 28.7 0.3 1.2e-05 25.7 0.0 2.7 2 2 0 2 2 2 1 Putative NAD(P)-binding E2_bind PF08825.10 CDF34107.1 - 0.00012 22.2 0.1 0.00029 20.9 0.1 1.6 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 CDF34107.1 - 0.0038 17.3 0.1 0.0086 16.1 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 CDF34107.1 - 0.0044 16.6 0.1 0.014 15.0 0.1 1.9 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 CDF34107.1 - 0.0053 17.3 0.1 0.018 15.6 0.1 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CDF34107.1 - 0.019 15.2 0.1 0.057 13.7 0.1 1.9 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 CDF34107.1 - 0.083 12.5 0.1 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 CDF34107.1 - 0.11 12.7 0.5 0.61 10.3 0.1 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain LRR_8 PF13855.6 CDF34108.1 - 1.3e-13 50.5 11.1 3.4e-05 23.5 5.3 4.1 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 CDF34108.1 - 9.7e-10 38.6 9.5 0.00016 22.0 1.8 4.0 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDF34108.1 - 6.8e-05 22.9 10.1 17 6.5 0.0 6.6 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 CDF34108.1 - 0.018 14.6 0.3 0.042 13.4 0.2 1.5 1 1 0 1 1 1 0 Leucine-rich repeat Stathmin PF00836.19 CDF34108.1 - 0.17 11.8 0.9 0.43 10.5 0.9 1.6 1 0 0 1 1 1 0 Stathmin family MMR_HSR1 PF01926.23 CDF34109.1 - 4.5e-51 171.7 0.6 6.3e-27 93.9 0.1 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 CDF34109.1 - 1.9e-32 111.4 0.1 3.3e-32 110.6 0.1 1.4 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 CDF34109.1 - 6.5e-21 74.5 0.2 1.6e-10 40.7 0.1 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDF34109.1 - 1.5e-12 47.5 0.5 0.00046 19.8 0.0 4.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 CDF34109.1 - 1.9e-11 43.7 0.2 0.00015 21.2 0.1 2.3 2 0 0 2 2 2 2 AIG1 family Dynamin_N PF00350.23 CDF34109.1 - 3.9e-11 43.3 0.6 0.0034 17.4 0.1 3.5 2 1 1 3 3 3 3 Dynamin family Roc PF08477.13 CDF34109.1 - 2.4e-07 31.0 0.0 0.033 14.4 0.0 2.8 2 2 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 CDF34109.1 - 4.3e-07 30.0 0.1 0.033 14.1 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase ABC_tran PF00005.27 CDF34109.1 - 7.2e-07 29.8 0.0 0.012 16.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter Ras PF00071.22 CDF34109.1 - 1.4e-05 24.7 0.1 0.019 14.6 0.0 2.7 2 1 0 2 2 2 2 Ras family AAA_16 PF13191.6 CDF34109.1 - 0.00024 21.6 0.1 0.14 12.5 0.0 3.0 2 2 0 2 2 2 1 AAA ATPase domain GBP PF02263.19 CDF34109.1 - 0.0016 17.8 0.0 0.78 8.9 0.0 2.2 2 0 0 2 2 2 2 Guanylate-binding protein, N-terminal domain cobW PF02492.19 CDF34109.1 - 0.0022 17.6 1.2 0.065 12.8 0.1 2.9 2 2 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDF34109.1 - 0.0036 17.6 0.0 1.3 9.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CDF34109.1 - 0.0051 16.2 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein RNA_helicase PF00910.22 CDF34109.1 - 0.0056 17.1 0.0 1 9.8 0.0 2.5 2 0 0 2 2 2 1 RNA helicase NTPase_1 PF03266.15 CDF34109.1 - 0.015 15.2 0.2 0.42 10.5 0.1 2.5 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.6 CDF34109.1 - 0.02 14.6 0.0 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 CDF34109.1 - 0.021 14.3 0.0 1.2 8.6 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 CDF34109.1 - 0.027 14.2 0.0 9.6 6.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.6 CDF34109.1 - 0.039 14.5 0.1 4.3 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 CDF34109.1 - 0.041 13.0 0.2 6.8 5.7 0.0 3.1 3 0 0 3 3 3 0 MCM P-loop domain AAA PF00004.29 CDF34109.1 - 0.057 13.9 0.0 9.3 6.7 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 CDF34109.1 - 0.062 12.5 0.0 2 7.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 CDF34109.1 - 0.063 12.6 0.0 14 4.9 0.0 3.0 3 1 0 3 3 3 0 FtsK/SpoIIIE family KTI12 PF08433.10 CDF34109.1 - 0.098 12.1 0.0 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_28 PF13521.6 CDF34109.1 - 0.14 12.4 0.3 28 4.9 0.0 2.8 3 0 0 3 3 2 0 AAA domain MeaB PF03308.16 CDF34109.1 - 0.16 10.9 1.0 1.5 7.7 0.0 2.6 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 CDF34109.1 - 0.19 11.6 0.0 5.7 6.8 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IIGP PF05049.13 CDF34109.1 - 0.19 10.8 0.0 18 4.3 0.0 2.3 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) HSF_DNA-bind PF00447.17 CDF34110.1 - 4e-27 94.7 0.2 7.9e-27 93.7 0.2 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding HAUS4 PF14735.6 CDF34110.1 - 0.028 14.1 1.5 0.045 13.5 1.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 DegS PF05384.11 CDF34110.1 - 0.032 13.7 1.1 0.055 13.0 1.1 1.3 1 0 0 1 1 1 0 Sensor protein DegS Uds1 PF15456.6 CDF34110.1 - 0.033 14.4 0.7 0.14 12.3 0.7 2.0 2 0 0 2 2 2 0 Up-regulated During Septation Nup88 PF10168.9 CDF34110.1 - 0.085 10.7 0.6 0.11 10.3 0.6 1.1 1 0 0 1 1 1 0 Nuclear pore component APG6_N PF17675.1 CDF34112.1 - 2.1 8.9 0.0 2.1 8.9 0.0 4.0 4 0 0 4 4 4 0 Apg6 coiled-coil region Adeno_PIX PF03955.14 CDF34112.1 - 2.2 8.5 6.7 1.9 8.7 0.1 2.4 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Mucin PF01456.17 CDF34114.1 - 0.65 10.0 7.6 1.2 9.2 7.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_S19 PF00203.21 CDF34115.1 - 3.4e-20 71.7 0.0 1.2e-19 69.9 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S19 ECH_2 PF16113.5 CDF34116.1 - 3.9e-68 230.4 0.0 4.8e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDF34116.1 - 3.3e-19 69.2 0.0 2.4e-18 66.4 0.0 2.2 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase DUF3432 PF11914.8 CDF34117.1 - 0.47 10.7 10.3 0.52 10.6 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Pyrophosphatase PF00719.19 CDF34118.1 - 1.2e-55 187.7 0.0 1.8e-55 187.1 0.0 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase FBPase PF00316.20 CDF34118.1 - 1.8e-26 92.8 0.0 2.7e-25 88.9 0.0 2.1 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain YfmQ PF10787.9 CDF34118.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group Aegerolysin PF06355.13 CDF34118.1 - 0.23 11.5 0.6 0.44 10.6 0.2 1.6 2 0 0 2 2 2 0 Aegerolysin PIP5K PF01504.18 CDF34119.1 - 4.4e-65 219.6 1.5 7.8e-65 218.8 1.5 1.4 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Glyco_hydro_35 PF01301.19 CDF34120.1 - 1.8e-58 198.6 0.0 3.4e-43 148.5 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 CDF34120.1 - 5.2e-11 43.1 0.0 1.5e-09 38.5 0.0 2.5 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Glyco_hydro_42 PF02449.15 CDF34120.1 - 0.00057 19.3 0.0 0.00094 18.6 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Cellulase PF00150.18 CDF34120.1 - 0.014 14.9 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) COX6A PF02046.15 CDF34121.1 - 2.8e-05 24.5 0.2 0.0001 22.8 0.2 1.9 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIa 4PPT_N PF17837.1 CDF34121.1 - 0.0071 16.4 0.5 0.24 11.5 0.2 2.1 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase N-terminal domain Talin_middle PF09141.10 CDF34121.1 - 0.025 14.6 0.0 0.031 14.3 0.0 1.1 1 0 0 1 1 1 0 Talin, middle domain zf-RING_2 PF13639.6 CDF34124.1 - 1.4e-10 41.4 12.7 2.6e-10 40.5 12.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDF34124.1 - 1.9e-09 37.1 8.3 1.9e-09 37.1 8.3 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF34124.1 - 6e-06 26.0 12.5 9.9e-06 25.3 12.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF34124.1 - 4.2e-05 23.8 8.7 8.6e-05 22.8 8.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDF34124.1 - 0.00048 19.9 9.3 0.00048 19.9 9.3 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF34124.1 - 0.0006 19.7 11.6 0.0011 18.8 11.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDF34124.1 - 0.00074 19.3 11.7 0.0014 18.5 11.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF34124.1 - 0.0079 16.2 8.5 0.018 15.0 7.9 1.9 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDF34124.1 - 0.015 15.2 10.4 0.026 14.4 10.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CDF34124.1 - 0.44 10.6 8.1 1.1 9.3 8.1 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CDF34124.1 - 0.8 9.4 9.9 1.9 8.2 9.9 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Acyltransferase PF01553.21 CDF34125.1 - 1.3e-13 50.7 0.0 2.1e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase JmjN PF02375.17 CDF34125.1 - 0.099 12.6 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 jmjN domain Mito_carr PF00153.27 CDF34126.1 - 1.6e-58 194.6 5.5 1.5e-19 69.7 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PAP_fibrillin PF04755.12 CDF34127.1 - 0.062 13.2 0.0 0.068 13.1 0.0 1.1 1 0 0 1 1 1 0 PAP_fibrillin PAP_fibrillin PF04755.12 CDF34128.1 - 3e-06 27.3 0.1 4.6e-06 26.7 0.1 1.5 1 1 0 1 1 1 1 PAP_fibrillin MFS_1 PF07690.16 CDF34129.1 - 2.5e-30 105.6 48.7 3.3e-17 62.4 25.6 2.3 1 1 0 2 2 2 2 Major Facilitator Superfamily Flavi_capsid PF01003.19 CDF34129.1 - 0.23 11.2 0.1 0.44 10.3 0.1 1.4 1 0 0 1 1 1 0 Flavivirus capsid protein C Amidohydro_2 PF04909.14 CDF34131.1 - 4.6e-21 75.9 0.4 9.3e-21 74.9 0.4 1.5 1 0 0 1 1 1 1 Amidohydrolase Glyco_hydro_6 PF01341.17 CDF34132.1 - 1.3e-70 238.6 0.0 4e-69 233.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 6 WD40 PF00400.32 CDF34133.1 - 1.3e-14 54.4 4.7 0.00074 20.3 0.0 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat zf-C3HC4_3 PF13920.6 CDF34133.1 - 3.4e-09 36.4 7.7 5.9e-09 35.7 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF34133.1 - 1.4e-07 31.7 11.8 4.2e-07 30.2 11.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDF34133.1 - 1.9e-06 27.6 11.5 4.3e-06 26.5 11.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF34133.1 - 3.2e-06 26.9 10.8 6.1e-06 26.0 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF34133.1 - 6e-05 22.9 9.4 0.00017 21.4 9.4 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDF34133.1 - 0.00061 19.8 11.3 0.0017 18.3 11.2 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDF34133.1 - 0.00085 19.1 10.6 0.0022 17.8 10.4 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CDF34133.1 - 0.0023 18.2 8.2 0.0056 16.9 8.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain WD40_like PF17005.5 CDF34133.1 - 0.0027 17.1 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain zf-RING_6 PF14835.6 CDF34133.1 - 0.53 10.2 4.0 1.8 8.5 4.0 1.9 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 CDF34133.1 - 0.81 9.9 5.9 1.6 8.9 5.9 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 CDF34133.1 - 6.7 6.5 11.3 51 3.6 11.3 2.4 1 1 0 1 1 1 0 P-11 zinc finger zf-RING_11 PF17123.5 CDF34133.1 - 6.8 6.5 10.6 0.73 9.6 4.5 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 CDF34133.1 - 7.3 6.8 12.0 23 5.3 12.0 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING TPT PF03151.16 CDF34134.1 - 1.4e-100 336.4 23.2 1.7e-100 336.2 23.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDF34134.1 - 3.4e-09 37.0 30.8 1e-06 29.0 10.9 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CDF34134.1 - 6.6e-06 25.5 15.9 1.7e-05 24.2 15.9 1.6 1 1 0 1 1 1 1 UAA transporter family Myb_DNA-binding PF00249.31 CDF34135.1 - 6.4e-15 55.1 7.0 0.087 13.0 0.3 5.6 5 0 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 CDF34135.1 - 4.9e-14 52.5 6.1 0.036 14.4 0.6 5.9 5 0 0 5 5 5 5 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF34135.1 - 1.9e-11 44.0 3.7 0.045 14.0 0.1 5.8 6 0 0 6 6 6 3 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 CDF34135.1 - 2.1e-06 27.8 0.0 3 8.1 0.0 4.8 5 0 0 5 5 5 3 Rap1 Myb domain MBF1 PF08523.10 CDF34135.1 - 1.4 9.4 13.6 2.7 8.5 0.3 4.5 4 0 0 4 4 4 0 Multiprotein bridging factor 1 CarbpepA_inh PF02977.15 CDF34136.1 - 0.23 11.2 10.6 5.7 6.8 4.2 3.2 2 1 1 3 3 3 0 Carboxypeptidase A inhibitor DX PF01666.17 CDF34136.1 - 7.2 7.1 13.1 0.53 10.8 0.7 3.0 3 0 0 3 3 3 0 DX module Glyco_hydro_108 PF05838.12 CDF34137.1 - 0.022 15.2 0.0 0.076 13.5 0.0 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase 108 CpeS PF09367.10 CDF34141.1 - 4e-54 183.1 0.9 4.5e-54 182.9 0.9 1.0 1 0 0 1 1 1 1 CpeS-like protein Aha1_N PF09229.11 CDF34141.1 - 0.022 14.9 0.5 0.033 14.4 0.5 1.2 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal EamA PF00892.20 CDF34142.1 - 3.2e-13 50.0 32.3 7.6e-07 29.4 12.7 3.2 3 0 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 CDF34142.1 - 0.043 13.0 12.2 0.27 10.4 12.2 2.2 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport CRT-like PF08627.10 CDF34142.1 - 0.59 9.0 10.7 2.6 6.9 3.1 2.3 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like GAF PF01590.26 CDF34143.1 - 0.0088 16.7 0.0 0.011 16.4 0.0 1.1 1 0 0 1 1 1 1 GAF domain bHLH-MYC_N PF14215.6 CDF34143.1 - 0.056 13.7 0.0 0.065 13.5 0.0 1.1 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal HTH_Tnp_Tc3_1 PF11427.8 CDF34144.1 - 2e-08 33.9 0.0 3.7e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF34144.1 - 4e-06 26.5 2.0 6.6e-06 25.8 0.4 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF34144.1 - 4.2e-05 23.2 1.0 8.7e-05 22.2 0.1 2.0 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDF34144.1 - 0.0046 16.9 0.4 0.013 15.5 0.4 1.8 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 CDF34144.1 - 0.0099 16.1 2.6 0.011 15.9 0.9 1.9 1 1 1 2 2 2 1 Transposase HTH_32 PF13565.6 CDF34144.1 - 0.018 15.6 8.2 2.2 9.0 0.2 3.1 1 1 2 3 3 3 0 Homeodomain-like domain HTH_11 PF08279.12 CDF34144.1 - 0.038 13.9 0.1 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 HTH domain PI3_PI4_kinase PF00454.27 CDF34145.1 - 4e-48 164.4 0.0 7.1e-48 163.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CDF34145.1 - 2.3e-06 27.3 0.7 4.4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 FATC domain HEAT PF02985.22 CDF34145.1 - 0.85 10.0 2.6 6.9 7.2 0.1 4.3 4 0 0 4 4 4 0 HEAT repeat zf-LSD1 PF06943.12 CDF34146.1 - 0.00031 20.5 0.1 0.00053 19.8 0.1 1.5 1 0 0 1 1 1 1 LSD1 zinc finger GST_N_2 PF13409.6 CDF34147.1 - 4.7e-19 68.5 0.0 2.1e-18 66.4 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDF34147.1 - 1.9e-11 43.8 0.0 5.8e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDF34147.1 - 1.8e-09 37.7 0.0 3.4e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDF34147.1 - 2.7e-08 33.9 0.0 5.1e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDF34147.1 - 4.8e-05 23.7 0.0 0.0011 19.3 0.0 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 CDF34147.1 - 0.011 15.5 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Phosphodiest PF01663.22 CDF34148.1 - 1.3e-69 235.5 2.5 1.6e-69 235.2 2.5 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 CDF34148.1 - 8.3e-05 22.8 0.1 0.00017 21.7 0.1 1.5 1 0 0 1 1 1 1 PglZ domain Metalloenzyme PF01676.18 CDF34148.1 - 0.00023 20.6 0.1 0.00041 19.8 0.1 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CDF34148.1 - 0.0066 15.9 0.8 0.45 9.8 0.8 2.2 1 1 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 CDF34148.1 - 0.016 14.3 0.1 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) N6_Mtase PF02384.16 CDF34148.1 - 0.21 10.8 0.0 0.59 9.3 0.0 1.7 2 0 0 2 2 2 0 N-6 DNA Methylase Pkinase PF00069.25 CDF34151.1 - 7.8e-66 222.1 0.0 9.3e-66 221.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34151.1 - 1.3e-28 100.0 0.0 1.8e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34151.1 - 6.2e-07 29.0 0.0 2.5e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDF34151.1 - 1.5e-06 27.3 0.0 2e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF34151.1 - 0.0016 18.4 0.4 0.0037 17.2 0.3 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF34151.1 - 0.037 13.6 0.3 0.06 12.9 0.3 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CDF34151.1 - 0.037 13.4 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF34151.1 - 0.11 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 CDF34151.1 - 0.33 9.9 0.1 0.5 9.3 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Peptidase_M17 PF00883.21 CDF34152.1 - 2.7e-112 375.1 4.0 3.9e-112 374.6 4.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDF34152.1 - 1.3e-14 54.1 3.8 3.2e-14 52.9 1.5 2.6 3 0 0 3 3 3 1 Cytosol aminopeptidase family, N-terminal domain RL11D PF11088.8 CDF34153.1 - 0.48 10.7 3.4 0.23 11.8 1.5 1.6 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 CTV_P33 PF07184.11 CDF34153.1 - 1.3 8.0 9.8 0.17 10.9 0.1 2.2 1 1 1 2 2 2 0 Citrus tristeza virus P33 protein MAGE_N PF12440.8 CDF34154.1 - 0.044 14.4 5.0 0.1 13.3 5.0 1.7 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal tRNA_anti-codon PF01336.25 CDF34155.1 - 0.13 12.2 0.5 0.48 10.5 0.5 1.9 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain AMH_N PF04709.12 CDF34163.1 - 0.2 10.5 0.3 0.27 10.1 0.3 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region RT_RNaseH PF17917.1 CDF34164.1 - 4e-30 104.2 0.4 1.3e-28 99.4 0.0 2.7 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF34164.1 - 3.8e-20 71.8 0.2 1.6e-19 69.8 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF34164.1 - 7.1e-16 58.5 0.1 1.5e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF34164.1 - 3.5e-15 55.8 0.0 7.3e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF34164.1 - 3.9e-07 29.8 0.5 8.5e-05 22.2 0.2 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF34164.1 - 0.0015 18.7 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 CDF34164.1 - 0.1 12.4 0.4 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain Sel1 PF08238.12 CDF34171.1 - 8e-08 32.7 0.0 0.002 18.8 0.0 2.2 2 0 0 2 2 2 2 Sel1 repeat TPR_7 PF13176.6 CDF34171.1 - 0.022 14.8 0.5 0.5 10.5 0.1 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat HetR_C PF18460.1 CDF34171.1 - 0.027 14.4 0.1 0.032 14.1 0.1 1.2 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain TPR_6 PF13174.6 CDF34171.1 - 0.09 13.5 0.1 3.2 8.6 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat NAM-associated PF14303.6 CDF34175.1 - 0.29 11.8 4.2 0.33 11.6 2.8 1.7 1 1 0 2 2 2 0 No apical meristem-associated C-terminal domain Epimerase PF01370.21 CDF34176.1 - 2.9e-08 33.5 0.2 4.4e-08 32.9 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDF34176.1 - 4.8e-07 29.5 0.2 6.1e-07 29.2 0.2 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CDF34176.1 - 0.00012 21.6 0.0 0.00016 21.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.19 CDF34176.1 - 0.003 16.6 0.0 0.0039 16.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 CDF34176.1 - 0.0056 16.3 0.2 0.0073 15.9 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family UDPG_MGDP_dh_N PF03721.14 CDF34176.1 - 0.0061 16.2 0.2 0.0087 15.7 0.2 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain KR PF08659.10 CDF34176.1 - 0.046 13.6 0.1 0.064 13.2 0.1 1.2 1 0 0 1 1 1 0 KR domain TrkA_N PF02254.18 CDF34176.1 - 0.066 13.5 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.24 CDF34176.1 - 0.13 11.8 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Polysacc_synt_2 PF02719.15 CDF34176.1 - 0.17 11.0 0.2 0.22 10.6 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Hpr_kinase_C PF07475.12 CDF34176.1 - 0.19 11.3 0.2 0.31 10.6 0.2 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain DUF913 PF06025.12 CDF34179.1 - 4.8e-34 117.9 0.0 4.8e-34 117.9 0.0 4.4 4 0 0 4 4 4 2 Domain of Unknown Function (DUF913) UBA PF00627.31 CDF34179.1 - 5.4e-05 23.0 0.0 0.00039 20.3 0.0 2.4 2 0 0 2 2 2 1 UBA/TS-N domain Spidroin_MaSp PF11260.8 CDF34179.1 - 9.1 6.7 9.7 1.1 9.5 1.1 3.7 3 0 0 3 3 3 0 Major ampullate spidroin 1 and 2 Atx10homo_assoc PF09759.9 CDF34182.1 - 3.3e-10 39.9 1.9 0.022 14.8 0.0 4.1 4 0 0 4 4 4 3 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 CDF34182.1 - 6.9e-06 25.9 3.0 0.028 14.5 0.0 5.1 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 CDF34182.1 - 0.00045 20.2 0.4 0.15 12.0 0.1 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF3361) Pkinase PF00069.25 CDF34183.1 - 2.9e-68 230.1 0.0 4e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34183.1 - 1.1e-30 106.8 0.0 7e-30 104.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF34183.1 - 0.00066 19.7 0.1 0.015 15.3 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF34183.1 - 0.0038 16.8 0.1 0.007 16.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 CDF34183.1 - 0.016 14.6 0.1 0.04 13.3 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF34183.1 - 0.041 13.2 0.0 0.13 11.6 0.0 1.8 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 CDF34183.1 - 0.075 12.6 0.2 0.16 11.5 0.2 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase zf-MIZ PF02891.20 CDF34185.1 - 4.8e-19 67.8 1.1 1e-18 66.8 1.1 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CDF34185.1 - 2e-09 37.1 0.2 3.9e-09 36.2 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 CDF34185.1 - 0.33 10.9 1.2 0.65 9.9 1.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Nic96 PF04097.14 CDF34186.1 - 1.1e-38 133.1 0.0 9.2e-38 130.1 0.0 1.9 1 1 0 1 1 1 1 Nup93/Nic96 Cul7 PF11515.8 CDF34186.1 - 0.19 12.0 0.0 0.44 10.9 0.0 1.5 1 0 0 1 1 1 0 Mouse development and cellular proliferation protein Cullin-7 RRM_1 PF00076.22 CDF34187.1 - 1.4e-29 101.7 0.0 1.1e-16 60.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF34187.1 - 3.1e-07 30.4 0.0 1.3e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif OB_RNB PF08206.11 CDF34187.1 - 0.0012 18.5 0.2 0.18 11.5 0.0 2.5 2 0 0 2 2 2 1 Ribonuclease B OB domain DUF4259 PF14078.6 CDF34187.1 - 0.0076 17.0 1.9 0.012 16.3 1.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4259) Macoilin PF09726.9 CDF34187.1 - 0.2 10.2 2.6 0.14 10.7 1.4 1.3 2 0 0 2 2 2 0 Macoilin family TFIIA PF03153.13 CDF34187.1 - 0.46 10.4 6.7 0.57 10.1 6.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MMS1_N PF10433.9 CDF34189.1 - 2.4e-87 293.6 0.0 3.7e-87 293.0 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CDF34189.1 - 3.8e-61 207.2 0.0 2.6e-60 204.4 0.0 2.5 3 1 0 3 3 3 1 CPSF A subunit region TruB_C PF09142.11 CDF34189.1 - 0.099 12.4 0.1 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal WD40 PF00400.32 CDF34190.1 - 4.3e-13 49.5 10.5 2.3e-06 28.2 0.3 7.0 7 1 1 8 8 8 4 WD domain, G-beta repeat RRM_1 PF00076.22 CDF34191.1 - 4e-14 52.2 0.1 5.7e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_A22B PF04258.13 CDF34192.1 - 1.3e-56 192.2 7.7 1.8e-56 191.7 7.7 1.1 1 0 0 1 1 1 1 Signal peptide peptidase FeoA PF04023.14 CDF34192.1 - 0.078 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 FeoA domain DUF3539 PF12058.8 CDF34192.1 - 0.1 12.8 0.3 0.25 11.5 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) FAD-SLDH PF12318.8 CDF34192.1 - 0.11 12.5 0.5 0.3 11.2 0.5 1.7 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase Ribosomal_S13_N PF08069.12 CDF34193.1 - 1.6e-30 104.9 0.2 2.8e-30 104.1 0.2 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 CDF34193.1 - 2.4e-14 53.3 1.7 3.6e-14 52.7 1.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 HTH_3 PF01381.22 CDF34194.1 - 3.2e-12 46.3 0.2 5e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix MBF1 PF08523.10 CDF34194.1 - 3.2e-07 30.7 6.6 9.6e-07 29.2 1.4 3.0 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_31 PF13560.6 CDF34194.1 - 9e-07 29.2 0.0 1.4e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDF34194.1 - 0.00017 21.5 0.1 0.00026 21.0 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CDF34194.1 - 0.032 14.2 0.1 0.052 13.5 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain WD40 PF00400.32 CDF34197.1 - 8.8e-56 184.6 47.9 1e-06 29.4 0.6 10.6 10 0 0 10 10 10 9 WD domain, G-beta repeat TIR_2 PF13676.6 CDF34197.1 - 3.7e-18 66.3 0.0 6.5e-17 62.2 0.0 3.0 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF34197.1 - 6.6e-17 61.5 0.0 1.5e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF34197.1 - 5.9e-07 29.4 0.0 1.3e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF34197.1 - 1.1e-06 28.8 16.9 0.44 10.9 0.1 7.1 1 1 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain MspA PF09203.11 CDF34197.1 - 0.00044 20.2 17.9 0.069 13.0 1.9 4.8 3 2 1 4 4 4 2 MspA Nup160 PF11715.8 CDF34197.1 - 0.0016 17.2 15.5 9.9 4.7 0.1 8.3 7 2 2 10 10 10 1 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF34197.1 - 0.0044 17.3 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain APAF1_C PF17908.1 CDF34197.1 - 0.047 13.7 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain TIR-like PF10137.9 CDF34197.1 - 0.085 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain CCT PF06203.14 CDF34199.1 - 9.8e-17 60.7 12.3 1.7e-16 60.0 12.3 1.4 1 0 0 1 1 1 1 CCT motif CCT_2 PF09425.10 CDF34199.1 - 1.1 9.2 8.6 0.22 11.4 4.1 2.2 2 0 0 2 2 2 0 Divergent CCT motif Hamartin PF04388.12 CDF34199.1 - 1.2 7.7 7.6 1.4 7.5 7.6 1.2 1 0 0 1 1 1 0 Hamartin protein An_peroxidase PF03098.15 CDF34200.1 - 1.2e-119 400.4 0.0 1.4e-119 400.1 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Meth_synt_2 PF01717.18 CDF34201.1 - 5e-145 482.8 0.0 4.4e-141 469.8 0.0 2.8 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CDF34201.1 - 3.9e-86 289.4 0.0 2.2e-80 270.5 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 CDF34201.1 - 0.05 12.7 0.2 0.6 9.2 0.0 2.5 3 0 0 3 3 3 0 Uroporphyrinogen decarboxylase (URO-D) DSHCT PF08148.12 CDF34202.1 - 8.7e-37 126.3 0.0 1.8e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CDF34202.1 - 3.8e-15 56.1 0.0 1e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 CDF34202.1 - 1.5e-11 44.7 0.0 2.4e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.31 CDF34202.1 - 8.1e-07 29.4 0.1 4.4e-06 27.0 0.1 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34202.1 - 1.3e-06 28.5 0.0 2.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DDE_1 PF03184.19 CDF34203.1 - 6.3e-08 32.5 0.1 1.2e-07 31.6 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Chalcone_2 PF16035.5 CDF34209.1 - 3.5e-11 43.3 0.1 2.1e-09 37.4 0.1 2.2 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone PF02431.15 CDF34209.1 - 8.6e-07 28.6 0.0 2.6e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Chalcone-flavanone isomerase Chalcone_3 PF16036.5 CDF34209.1 - 8.7e-06 26.0 0.1 0.0014 18.8 0.1 2.2 1 1 0 1 1 1 1 Chalcone isomerase-like Adaptin_N PF01602.20 CDF34210.1 - 9.5e-115 384.1 3.8 1.2e-114 383.8 3.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 CDF34210.1 - 1.3e-44 152.0 0.0 3.4e-44 150.6 0.0 1.8 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 CDF34210.1 - 2.9e-23 82.2 0.0 8.3e-23 80.7 0.0 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 CDF34210.1 - 8.7e-16 58.1 7.5 1e-06 29.0 0.0 5.7 3 2 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 CDF34210.1 - 6.8e-12 45.7 8.8 7.6e-07 29.3 1.2 4.4 4 1 1 5 5 5 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CDF34210.1 - 1.4e-05 25.4 9.5 0.00085 19.8 0.7 5.0 6 0 0 6 6 6 2 HEAT-like repeat HEAT PF02985.22 CDF34210.1 - 6.8e-05 22.8 9.5 7.2 7.2 0.2 7.6 8 0 0 8 8 8 2 HEAT repeat U3snoRNP10 PF12397.8 CDF34210.1 - 0.084 13.2 4.1 0.34 11.3 1.7 3.2 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 HEAT_PBS PF03130.16 CDF34210.1 - 2.8 8.9 7.6 2.4e+02 2.9 0.4 5.8 6 2 0 6 6 6 0 PBS lyase HEAT-like repeat CLASP_N PF12348.8 CDF34210.1 - 4.5 6.8 7.6 3.2 7.2 0.4 3.6 4 1 1 5 5 5 0 CLASP N terminal ANTH PF07651.16 CDF34211.1 - 7e-41 140.0 0.0 1.4e-40 139.1 0.0 1.4 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 CDF34211.1 - 0.00031 20.8 0.0 0.00061 19.8 0.0 1.4 1 0 0 1 1 1 1 ENTH domain Ribo_biogen_C PF04034.13 CDF34212.1 - 6.8e-50 168.1 0.0 8.9e-50 167.7 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CDF34212.1 - 2.9e-09 36.6 0.0 5.1e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI CDC45 PF02724.14 CDF34212.1 - 8.5 4.5 5.7 10 4.3 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Amino_oxidase PF01593.24 CDF34213.1 - 4.9e-47 161.2 2.3 2e-18 67.0 0.0 3.9 4 0 0 4 4 4 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF34213.1 - 8.5e-11 41.9 0.0 2.5e-09 37.2 0.0 2.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF34213.1 - 1e-05 25.3 0.7 7.8e-05 22.4 0.7 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF34213.1 - 0.00016 21.0 0.0 0.00057 19.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDF34213.1 - 0.00023 21.2 0.2 0.00051 20.1 0.2 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 CDF34213.1 - 0.00028 19.7 0.1 0.00048 19.0 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CDF34213.1 - 0.00033 20.0 0.1 0.00063 19.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CDF34213.1 - 0.00048 19.3 0.1 0.00092 18.4 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 CDF34213.1 - 0.00055 19.4 0.1 0.0012 18.3 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDF34213.1 - 0.0037 16.4 1.0 0.0078 15.3 1.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CDF34213.1 - 0.013 16.1 0.1 0.04 14.5 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDF34213.1 - 0.035 13.4 0.1 0.066 12.5 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Glu_dehyd_C PF16912.5 CDF34213.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 CDF34213.1 - 0.17 11.1 0.1 0.26 10.5 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 CDF34213.1 - 0.17 10.6 0.1 0.26 10.0 0.1 1.2 1 0 0 1 1 1 0 MCRA family TPT PF03151.16 CDF34216.1 - 5.8e-88 295.0 12.8 1.4e-87 293.8 12.8 1.5 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDF34216.1 - 1.5e-11 44.6 29.4 8.5e-07 29.2 13.8 2.4 2 0 0 2 2 2 2 EamA-like transporter family NB-ARC PF00931.22 CDF34217.1 - 1.4e-15 57.2 0.0 2.8e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain WD40 PF00400.32 CDF34217.1 - 1.9e-15 56.9 10.0 1.2e-05 25.9 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34217.1 - 0.0009 19.5 0.3 2.5 8.5 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 CDF34217.1 - 0.0013 19.0 0.0 0.0047 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CDF34217.1 - 0.069 13.1 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 NACHT domain WSC PF01822.19 CDF34217.1 - 0.3 11.3 2.1 0.32 11.2 0.3 2.0 2 0 0 2 2 2 0 WSC domain MACPF PF01823.19 CDF34218.1 - 9.7e-12 45.4 0.1 1.5e-11 44.8 0.1 1.2 1 0 0 1 1 1 1 MAC/Perforin domain Radical_SAM_C PF16199.5 CDF34219.1 - 8.3e-32 109.1 0.0 1.5e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CDF34219.1 - 5.2e-22 79.0 0.1 4.8e-21 75.9 0.0 2.4 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 CDF34219.1 - 1.6e-08 34.8 0.1 3.1e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF34219.1 - 1.1e-05 25.4 0.0 2.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF34219.1 - 0.0032 17.4 0.0 0.0074 16.2 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 CDF34219.1 - 0.0036 17.7 0.0 0.0067 16.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain YGGT PF02325.17 CDF34220.1 - 3.2e-15 56.3 3.9 5.4e-15 55.6 3.9 1.3 1 0 0 1 1 1 1 YGGT family SRP54 PF00448.22 CDF34221.1 - 2.7e-69 232.7 1.5 1.5e-66 223.8 0.1 2.1 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CDF34221.1 - 1.7e-09 37.7 4.1 5.8e-09 36.0 4.1 2.0 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_16 PF13191.6 CDF34221.1 - 2.5e-06 28.0 1.2 1.6e-05 25.4 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDF34221.1 - 6.5e-05 23.2 0.2 0.0011 19.2 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 CDF34221.1 - 8e-05 22.4 0.9 0.0006 19.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CDF34221.1 - 0.00014 20.9 1.5 0.021 13.8 0.2 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_19 PF13245.6 CDF34221.1 - 0.00019 21.8 0.0 0.00043 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CDF34221.1 - 0.00028 20.9 0.8 0.0011 19.0 0.1 2.2 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDF34221.1 - 0.00036 20.5 0.2 0.045 13.7 0.2 2.6 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDF34221.1 - 0.00048 19.5 0.1 0.0016 17.8 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 CDF34221.1 - 0.0012 18.6 0.4 0.011 15.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain ArsA_ATPase PF02374.15 CDF34221.1 - 0.0028 16.9 1.7 0.14 11.3 0.1 2.9 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_33 PF13671.6 CDF34221.1 - 0.0036 17.5 0.5 0.031 14.5 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 CDF34221.1 - 0.0047 17.2 0.1 0.017 15.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 CDF34221.1 - 0.0063 15.5 0.0 0.014 14.4 0.0 1.6 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain Fer4_NifH PF00142.18 CDF34221.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NACHT PF05729.12 CDF34221.1 - 0.013 15.5 3.6 0.086 12.7 0.1 3.0 3 1 0 3 3 3 0 NACHT domain ATP_bind_1 PF03029.17 CDF34221.1 - 0.024 14.4 0.0 0.076 12.8 0.0 1.9 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein HisKA PF00512.25 CDF34221.1 - 0.033 14.2 3.4 0.66 10.0 3.4 2.8 1 1 0 1 1 1 0 His Kinase A (phospho-acceptor) domain ABC_tran PF00005.27 CDF34221.1 - 0.036 14.6 0.3 0.11 13.0 0.0 1.8 2 1 0 2 2 1 0 ABC transporter NTPase_1 PF03266.15 CDF34221.1 - 0.04 13.8 0.1 0.14 12.0 0.0 2.1 2 0 0 2 2 1 0 NTPase Helicase_RecD PF05127.14 CDF34221.1 - 0.046 13.6 0.3 0.1 12.5 0.3 1.8 1 1 0 1 1 1 0 Helicase ApbA PF02558.16 CDF34221.1 - 0.047 13.3 0.0 0.087 12.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA T2SSE_N PF05157.15 CDF34221.1 - 0.05 13.9 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein E, N-terminal domain ResIII PF04851.15 CDF34221.1 - 0.056 13.4 0.1 0.27 11.2 0.1 1.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 CDF34221.1 - 0.056 13.3 0.2 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA PF00004.29 CDF34221.1 - 0.076 13.4 0.2 0.27 11.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 CDF34221.1 - 0.09 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.6 CDF34221.1 - 0.09 12.8 0.0 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 CDF34221.1 - 0.11 12.2 0.3 0.57 9.8 0.1 2.3 3 0 0 3 3 2 0 Thymidylate kinase NTP_transf_3 PF12804.7 CDF34221.1 - 0.13 12.7 1.3 0.23 11.8 0.1 1.8 2 1 0 2 2 1 0 MobA-like NTP transferase domain DUF87 PF01935.17 CDF34221.1 - 1.4 9.0 5.6 1.2 9.2 0.4 2.5 1 1 2 3 3 3 0 Helicase HerA, central domain AAA_18 PF13238.6 CDF34221.1 - 4.5 7.8 7.1 3.2 8.3 0.2 2.8 2 2 0 2 2 2 0 AAA domain Mito_carr PF00153.27 CDF34223.1 - 2e-26 91.7 4.0 9.2e-12 44.7 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L34e PF01199.18 CDF34224.1 - 1.3e-33 115.1 1.4 1.3e-33 115.1 1.4 1.4 2 0 0 2 2 2 1 Ribosomal protein L34e HTH_Tnp_Tc3_1 PF11427.8 CDF34225.1 - 9.6e-13 47.8 0.0 1.8e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF34225.1 - 1.1e-09 37.9 0.2 1.2e-08 34.6 0.0 2.2 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF34225.1 - 0.00059 20.4 1.3 0.0052 17.4 0.4 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.12 CDF34225.1 - 0.054 13.4 0.1 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 HTH domain TrmB PF01978.19 CDF34225.1 - 0.055 13.4 0.1 3.2 7.7 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 CDF34225.1 - 0.073 13.1 0.1 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1456 PF07308.13 CDF34225.1 - 0.094 13.1 0.0 0.42 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) Adenine_glyco PF03352.13 CDF34229.1 - 4.5e-64 215.5 0.1 4.5e-64 215.5 0.1 1.4 2 0 0 2 2 2 1 Methyladenine glycosylase Tim54 PF11711.8 CDF34229.1 - 0.0087 14.9 9.6 0.013 14.3 9.6 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Rtf2 PF04641.12 CDF34229.1 - 0.15 11.4 13.2 0.24 10.7 13.2 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger RNA_polI_A34 PF08208.11 CDF34229.1 - 0.18 11.9 19.1 0.27 11.3 19.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 CDF34229.1 - 0.31 10.8 7.1 0.45 10.3 7.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDF34229.1 - 0.48 9.1 3.2 0.55 8.9 3.2 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDF34229.1 - 0.66 8.2 8.2 0.91 7.7 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Coilin_N PF15862.5 CDF34229.1 - 0.84 9.4 11.5 1.1 9.1 10.4 1.7 2 0 0 2 2 2 0 Coilin N-terminus SHR3_chaperone PF08229.11 CDF34229.1 - 1.4 7.8 5.0 2.4 7.1 5.0 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 Eapp_C PF10238.9 CDF34229.1 - 2 8.5 6.2 3.9 7.5 6.2 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein MAP17 PF15807.5 CDF34229.1 - 2.2 8.5 7.8 4.7 7.5 7.8 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Peptidase_S49_N PF08496.10 CDF34229.1 - 7.9 6.5 12.9 14 5.7 12.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RNA_pol_Rpc4 PF05132.14 CDF34229.1 - 8.7 6.8 10.9 7.8 6.9 9.2 1.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 zf-C2H2_4 PF13894.6 CDF34230.1 - 0.034 15.0 8.7 0.82 10.7 0.0 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_12 PF18658.1 CDF34230.1 - 0.064 12.8 1.2 1.7 8.3 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger C2H2-type Hamartin PF04388.12 CDF34230.1 - 0.16 10.6 0.6 0.17 10.5 0.6 1.1 1 0 0 1 1 1 0 Hamartin protein zf-C2H2 PF00096.26 CDF34230.1 - 1.8 9.2 0.0 1.8 9.2 0.0 3.8 3 1 0 3 3 3 0 Zinc finger, C2H2 type RIBIOP_C PF04950.12 CDF34232.1 - 1.1e-67 228.6 0.4 1.9e-67 227.8 0.0 1.6 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CDF34232.1 - 3.2e-22 78.4 0.0 7.8e-22 77.2 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 CDF34232.1 - 7.7e-06 25.6 0.0 0.00016 21.2 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDF34232.1 - 7.3e-05 23.2 0.0 0.00021 21.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 CDF34232.1 - 0.00065 19.7 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDF34232.1 - 0.0029 17.9 0.3 0.0099 16.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDF34232.1 - 0.0037 17.3 1.1 0.015 15.3 0.3 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CDF34232.1 - 0.0063 17.1 2.3 0.082 13.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CDF34232.1 - 0.0093 16.5 0.8 0.022 15.3 0.0 2.0 2 0 0 2 2 1 1 ABC transporter AAA_30 PF13604.6 CDF34232.1 - 0.018 14.7 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDF34232.1 - 0.02 14.1 0.0 0.044 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA PF00004.29 CDF34232.1 - 0.042 14.3 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CDF34232.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 CDF34232.1 - 0.062 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 CDF34232.1 - 0.077 13.2 4.2 0.11 12.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF34232.1 - 0.08 12.1 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Dynamin_N PF00350.23 CDF34232.1 - 7.6 6.6 6.0 1.2 9.2 0.2 2.6 2 1 1 3 3 3 0 Dynamin family Sel1 PF08238.12 CDF34233.1 - 1.1e-126 410.4 59.7 1.4e-07 31.9 0.1 21.3 21 0 0 21 21 21 20 Sel1 repeat Pkinase_Tyr PF07714.17 CDF34233.1 - 1.2e-15 57.5 0.0 2.1e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF34233.1 - 1.3e-15 57.5 0.0 2.6e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_7 PF13176.6 CDF34233.1 - 0.00024 20.9 22.1 16 5.8 0.0 10.2 9 2 2 11 11 11 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF34233.1 - 0.037 14.7 25.4 8.6 7.2 0.0 11.0 14 0 0 14 14 14 0 Tetratricopeptide repeat DUF2219 PF09982.9 CDF34233.1 - 0.055 12.7 3.1 61 2.7 0.0 4.4 4 1 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2219) Kdo PF06293.14 CDF34233.1 - 0.11 11.9 0.0 0.27 10.6 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_19 PF14559.6 CDF34233.1 - 0.34 11.4 25.9 3.8 8.1 0.0 9.6 11 0 0 11 11 11 0 Tetratricopeptide repeat RNA_pol_N PF01194.17 CDF34234.1 - 2.4e-29 101.4 1.8 3.1e-29 101.0 1.8 1.2 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit ProRS-C_1 PF09180.11 CDF34238.1 - 2.1e-20 72.7 0.7 7.1e-20 71.0 0.7 2.0 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 CDF34238.1 - 3.6e-18 65.5 0.1 7.7e-18 64.4 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CDF34238.1 - 3.9e-15 56.3 0.0 7.4e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SpoIIP PF07454.11 CDF34238.1 - 0.023 14.1 1.1 0.22 11.0 0.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Ribosomal_S13 PF00416.22 CDF34241.1 - 1.9e-51 173.7 2.9 2.4e-51 173.4 2.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Transpeptidase PF00905.22 CDF34243.1 - 0.19 10.9 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain EMP70 PF02990.16 CDF34245.1 - 8.1e-165 549.4 0.0 8.1e-165 549.4 0.0 1.9 1 1 1 2 2 2 2 Endomembrane protein 70 Hemocyanin_N PF03722.14 CDF34245.1 - 0.16 12.5 0.0 0.32 11.5 0.0 1.5 1 0 0 1 1 1 0 Hemocyanin, all-alpha domain RPN1_RPN2_N PF17781.1 CDF34248.1 - 7e-106 354.1 0.0 9.9e-106 353.6 0.0 1.2 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CDF34248.1 - 9.4e-27 92.8 0.0 1.8e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CDF34248.1 - 1.1e-17 63.5 14.4 4.6e-05 23.6 0.1 8.0 8 0 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CDF34248.1 - 8.7e-05 22.8 0.6 1.2 9.6 0.0 4.9 5 1 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 CDF34248.1 - 0.043 14.3 0.4 21 5.7 0.0 4.1 3 0 0 3 3 3 0 HEAT-like repeat UBA_3 PF09288.10 CDF34248.1 - 0.044 13.6 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain HEAT PF02985.22 CDF34248.1 - 0.11 12.8 0.0 4.2 7.9 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat DUF2465 PF10239.9 CDF34249.1 - 1.2e-21 77.4 0.0 1.7e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) Glyco_hydro_77 PF02446.17 CDF34252.1 - 2.1e-140 468.7 5.3 2.8e-140 468.3 5.3 1.1 1 0 0 1 1 1 1 4-alpha-glucanotransferase HDV_ag PF01517.18 CDF34257.1 - 0.17 11.6 1.2 0.18 11.6 1.2 1.0 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Mre11_DNA_bind PF04152.14 CDF34259.1 - 4.2e-21 76.0 0.0 6.7e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Androgen_recep PF02166.16 CDF34259.1 - 0.012 14.4 0.1 0.021 13.7 0.1 1.3 1 0 0 1 1 1 0 Androgen receptor Metallophos_2 PF12850.7 CDF34259.1 - 0.074 13.2 0.0 0.68 10.1 0.0 2.2 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Fumble PF03630.14 CDF34260.1 - 2.3e-72 243.9 0.0 3e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 Fumble RNase_PH PF01138.21 CDF34262.1 - 1.5e-11 44.9 0.0 2.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF34262.1 - 1.1e-09 38.1 0.0 1.8e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 M64_N PF16217.5 CDF34262.1 - 0.2 11.2 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase M64 N-terminus Syntaxin-6_N PF09177.11 CDF34264.1 - 0.061 13.9 0.1 0.12 13.0 0.1 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Syntaxin-6_N PF09177.11 CDF34265.1 - 0.029 14.9 0.1 0.051 14.1 0.1 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal zf-CHY PF05495.12 CDF34268.1 - 7.5e-10 39.2 9.4 1.5e-09 38.2 9.4 1.4 1 0 0 1 1 1 1 CHY zinc finger zf-HYPF PF07503.12 CDF34268.1 - 0.018 14.8 3.0 0.055 13.3 3.0 1.8 1 0 0 1 1 1 0 HypF finger Kin17_mid PF10357.9 CDF34273.1 - 5.4e-42 142.7 0.2 1.1e-41 141.7 0.2 1.5 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 CDF34273.1 - 4.7e-15 55.4 2.8 5.8e-15 55.2 1.0 2.0 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain zf-C2H2_jaz PF12171.8 CDF34273.1 - 9.1e-06 25.8 3.3 2.2e-05 24.6 3.3 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding KOW PF00467.29 CDF34273.1 - 0.00011 22.1 6.7 0.038 14.0 0.0 3.6 3 1 0 3 3 3 2 KOW motif zf-met PF12874.7 CDF34273.1 - 0.00018 21.8 3.7 0.00038 20.7 3.7 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDF34273.1 - 0.03 14.7 1.3 0.062 13.6 0.2 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) CHGN PF05679.16 CDF34274.1 - 1.2e-47 162.9 0.1 6.2e-47 160.6 0.1 1.9 1 1 1 2 2 2 1 Chondroitin N-acetylgalactosaminyltransferase DUF4768 PF15989.5 CDF34274.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4768) DUF1138 PF06592.13 CDF34276.1 - 4.8e-09 36.2 4.6 1.4e-08 34.7 0.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1138) COX4 PF02936.14 CDF34276.1 - 8.8e-09 35.5 0.0 1.1e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Topoisom_bac PF01131.20 CDF34277.1 - 3.7e-97 326.0 0.0 4.5e-97 325.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CDF34277.1 - 1.3e-14 54.2 0.0 2.6e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Cys_rich_CPCC PF14206.6 CDF34277.1 - 0.25 11.2 2.1 1.2 9.0 2.1 2.2 1 0 0 1 1 1 0 Cysteine-rich CPCC zf-piccolo PF05715.13 CDF34277.1 - 1.4 9.1 12.6 0.52 10.5 8.3 2.5 2 0 0 2 2 2 0 Piccolo Zn-finger Ribul_P_3_epim PF00834.19 CDF34278.1 - 1.8e-85 285.3 0.1 2.2e-85 285.1 0.1 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family SNF2_N PF00176.23 CDF34279.1 - 1.2e-49 169.0 0.0 1.9e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF34279.1 - 9e-06 26.0 0.0 1.8e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain F-box PF00646.33 CDF34279.1 - 0.0086 15.9 0.1 0.032 14.1 0.1 1.9 1 0 0 1 1 1 1 F-box domain zf-RING_UBOX PF13445.6 CDF34279.1 - 0.015 15.3 8.6 0.055 13.5 8.6 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 CDF34279.1 - 0.026 14.5 11.0 0.061 13.3 11.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain ResIII PF04851.15 CDF34279.1 - 0.043 13.8 0.0 5.5 7.0 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PSCyt2 PF07583.11 CDF34279.1 - 0.15 12.0 0.0 0.4 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1549) Prok-RING_4 PF14447.6 CDF34279.1 - 0.25 11.2 10.4 0.61 10.0 10.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDF34279.1 - 0.48 10.3 9.2 1.2 9.1 9.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF34279.1 - 1.7 8.6 8.5 4.1 7.3 8.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDF34279.1 - 3 8.1 7.8 6.7 7.0 7.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CDF34279.1 - 3.3 7.7 10.9 7 6.6 10.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AAA_2 PF07724.14 CDF34280.1 - 5.8e-39 133.9 0.1 5.2e-32 111.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 CDF34280.1 - 2.9e-12 47.2 0.1 9e-05 22.9 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDF34280.1 - 3.3e-07 30.4 0.3 0.00036 20.6 0.0 3.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 CDF34280.1 - 1e-06 28.7 1.6 2.8e-06 27.3 0.3 2.4 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 CDF34280.1 - 1.2e-06 29.0 3.5 7.3e-06 26.5 1.3 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDF34280.1 - 2.5e-06 27.8 0.6 0.00011 22.5 0.0 2.7 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.15 CDF34280.1 - 0.00086 19.3 0.9 0.12 12.3 0.0 2.3 2 0 0 2 2 2 1 NTPase MCM PF00493.23 CDF34280.1 - 0.001 18.2 0.0 0.072 12.2 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain AAA_18 PF13238.6 CDF34280.1 - 0.0011 19.5 0.0 0.0041 17.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF34280.1 - 0.0024 17.8 0.0 0.43 10.5 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 CDF34280.1 - 0.0036 16.9 0.2 0.76 9.3 0.2 2.6 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDF34280.1 - 0.0084 15.4 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RsgA_GTPase PF03193.16 CDF34280.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase CPT PF07931.12 CDF34280.1 - 0.013 15.4 0.0 0.075 12.9 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 CDF34280.1 - 0.02 15.1 0.0 0.049 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDF34280.1 - 0.025 14.9 0.7 0.14 12.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CDF34280.1 - 0.027 15.0 0.0 0.078 13.5 0.0 1.8 1 1 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 CDF34280.1 - 0.028 13.8 0.0 0.27 10.6 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TMEM65 PF10507.9 CDF34280.1 - 0.041 13.8 0.2 0.11 12.4 0.2 1.7 1 0 0 1 1 1 0 Transmembrane protein 65 AAA_3 PF07726.11 CDF34280.1 - 0.06 13.2 0.2 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDF34280.1 - 0.067 12.9 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDF34280.1 - 0.071 13.4 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 CDF34280.1 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Sigma54_activat PF00158.26 CDF34280.1 - 0.12 12.0 0.0 0.64 9.7 0.0 2.1 3 0 0 3 3 3 0 Sigma-54 interaction domain Abhydrolase_2 PF02230.16 CDF34281.1 - 3.6e-56 190.4 0.0 4.5e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CDF34281.1 - 9.8e-09 34.8 0.5 0.00028 20.2 0.0 2.6 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CDF34281.1 - 6.2e-06 26.2 0.1 0.0025 17.7 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CDF34281.1 - 1e-05 25.4 0.3 0.00022 21.0 0.2 2.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF34281.1 - 1.3e-05 25.9 1.8 2.4e-05 25.1 1.8 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CDF34281.1 - 1.8e-05 24.4 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 CDF34281.1 - 0.00028 20.7 0.0 0.00043 20.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDF34281.1 - 0.0014 18.2 1.2 0.012 15.1 0.1 2.3 1 1 1 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 CDF34281.1 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 CDF34281.1 - 0.016 13.9 0.0 0.023 13.4 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Cutinase PF01083.22 CDF34281.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Cutinase DDE_3 PF13358.6 CDF34283.1 - 4.3e-20 72.0 0.0 7.3e-20 71.2 0.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease HEPN_Swt1 PF18731.1 CDF34283.1 - 0.061 13.7 0.0 14 6.0 0.0 2.3 2 0 0 2 2 2 0 Swt1-like HEPN IF2_N PF04760.15 CDF34287.1 - 0.051 13.4 0.1 16 5.4 0.0 3.2 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region MGS PF02142.22 CDF34287.1 - 0.068 13.4 0.1 0.77 10.0 0.0 2.6 2 1 1 3 3 3 0 MGS-like domain zf-RING_4 PF14570.6 CDF34289.1 - 4.4e-19 68.0 10.0 4.4e-19 68.0 10.0 2.1 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 CDF34289.1 - 6.8e-07 29.1 9.5 1.3e-06 28.1 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 CDF34289.1 - 1.6e-05 24.4 4.9 1.6e-05 24.4 4.9 2.2 2 0 0 2 2 2 1 Rtf2 RING-finger zf-RING_2 PF13639.6 CDF34289.1 - 5.4e-05 23.4 11.4 5.4e-05 23.4 11.4 1.6 2 0 0 2 2 1 1 Ring finger domain RRM_1 PF00076.22 CDF34289.1 - 0.0013 18.6 0.0 0.0035 17.1 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.6 CDF34289.1 - 0.025 14.7 3.4 0.051 13.7 3.4 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger Baculo_IE-1 PF05290.11 CDF34289.1 - 0.055 13.4 3.8 0.093 12.7 3.8 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Spc29 PF17082.5 CDF34289.1 - 0.13 12.1 13.8 0.44 10.3 13.8 1.9 1 1 0 1 1 1 0 Spindle Pole Component 29 Prok-RING_4 PF14447.6 CDF34289.1 - 0.24 11.3 9.3 10 6.1 9.3 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CDF34289.1 - 0.9 9.5 13.9 0.36 10.7 10.4 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Spc24 PF08286.11 CDF34289.1 - 1.3 9.3 4.7 0.84 9.9 0.4 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 APC_rep PF18797.1 CDF34290.1 - 0.28 12.1 0.8 1.1e+02 3.8 0.0 4.1 4 1 1 5 5 5 0 Adenomatous polyposis coli (APC) repeat Peptidase_S24 PF00717.23 CDF34291.1 - 5.5e-08 32.7 0.0 1.1e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CDF34291.1 - 6.1e-07 29.3 0.0 5.3e-05 23.0 0.0 2.6 2 1 0 2 2 2 2 Signal peptidase, peptidase S26 Urm1 PF09138.11 CDF34292.1 - 4.2e-29 100.7 0.0 5.1e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 CDF34292.1 - 0.023 15.3 0.0 0.03 15.0 0.0 1.3 1 0 0 1 1 1 0 ThiS family Sld5 PF05916.11 CDF34293.1 - 1.6e-05 25.3 0.1 2.5e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 GINS complex protein Gal-3-0_sulfotr PF06990.11 CDF34294.1 - 1.4e-08 34.1 0.1 1.7e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 CDF34294.1 - 4.9e-08 33.2 0.1 7.5e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family Ank_2 PF12796.7 CDF34295.1 - 4.8e-18 65.5 0.2 4.6e-10 40.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDF34295.1 - 1.7e-17 63.2 0.3 1.4e-05 25.2 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDF34295.1 - 3.5e-17 62.5 0.1 5.9e-10 39.5 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CDF34295.1 - 7.9e-13 48.2 2.4 0.0029 18.0 0.8 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 CDF34295.1 - 4.4e-11 42.0 0.0 0.0007 19.9 0.0 4.3 3 0 0 3 3 3 3 Ankyrin repeat Glyco_hydro_20b PF02838.15 CDF34295.1 - 8.1e-09 36.3 0.0 2.6e-08 34.7 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 MTS PF05175.14 CDF34296.1 - 1.2e-11 44.4 0.0 2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDF34296.1 - 2.1e-07 31.6 0.0 5.4e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDF34296.1 - 2e-06 27.6 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 CDF34296.1 - 7.3e-05 22.5 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CDF34296.1 - 8e-05 22.5 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF34296.1 - 0.00025 21.7 0.0 0.00053 20.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF34296.1 - 0.00038 20.3 0.0 0.00061 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF34296.1 - 0.00048 20.7 0.0 0.0011 19.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDF34296.1 - 0.0014 18.4 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 CDF34296.1 - 0.0014 18.4 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 CDF34296.1 - 0.0015 18.0 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 CDF34296.1 - 0.0018 18.2 0.0 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_28 PF02636.17 CDF34296.1 - 0.0037 16.9 0.0 0.011 15.4 0.0 1.8 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 CDF34296.1 - 0.035 14.1 0.0 0.065 13.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain DUF43 PF01861.16 CDF34296.1 - 0.051 12.8 0.0 0.08 12.2 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain N6-adenineMlase PF10237.9 CDF34296.1 - 0.073 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase RrnaAD PF00398.20 CDF34296.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase GidB PF02527.15 CDF34296.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DREV PF05219.12 CDF34296.1 - 0.17 10.9 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_10 PF05971.12 CDF34296.1 - 0.18 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase NUDIX PF00293.28 CDF34297.1 - 6.7e-15 55.3 0.2 9.7e-15 54.8 0.2 1.2 1 0 0 1 1 1 1 NUDIX domain Nudix_N_2 PF14803.6 CDF34297.1 - 5.1e-10 39.1 5.8 5.1e-10 39.1 5.8 1.9 2 0 0 2 2 2 1 Nudix N-terminal DUF2757 PF10955.8 CDF34297.1 - 0.064 13.5 0.7 0.14 12.5 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) Glyco_hydro_130 PF04041.13 CDF34300.1 - 0.1 11.5 0.0 12 4.8 0.0 3.1 3 1 0 4 4 4 0 beta-1,4-mannooligosaccharide phosphorylase BNR_4 PF15892.5 CDF34300.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 BNR repeat-containing family member Asp_Glu_race_2 PF14669.6 CDF34300.1 - 0.2 11.3 0.0 2.6 7.7 0.1 2.1 2 0 0 2 2 2 0 Putative aspartate racemase DEAD PF00270.29 CDF34301.1 - 2.1e-40 138.3 1.3 2.3e-40 138.2 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF34301.1 - 2.2e-32 111.7 0.2 3.7e-31 107.7 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34301.1 - 6.1e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CDF34301.1 - 0.0018 18.6 0.4 0.0071 16.7 0.1 2.0 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 CDF34301.1 - 0.039 13.9 0.1 0.097 12.6 0.1 1.7 1 0 0 1 1 1 0 Flavivirus DEAD domain tRNA-synt_1b PF00579.25 CDF34301.1 - 0.08 12.3 0.0 0.47 9.7 0.0 2.1 2 1 0 2 2 2 0 tRNA synthetases class I (W and Y) Helicase_C PF00271.31 CDF34304.1 - 1.1e-14 54.7 0.0 2.6e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF34304.1 - 1.2e-09 38.2 0.0 3.4e-09 36.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 CDF34304.1 - 3.2e-06 27.5 0.2 1.9e-05 25.0 0.2 2.4 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 CDF34304.1 - 0.0051 16.8 0.0 0.017 15.1 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Acetyltransf_8 PF13523.6 CDF34304.1 - 0.15 11.7 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Helicase_C PF00271.31 CDF34306.1 - 9.5e-18 64.6 0.0 2.1e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF34306.1 - 0.0071 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase TRAF_BIRC3_bd PF16673.5 CDF34306.1 - 0.048 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Pkinase PF00069.25 CDF34307.1 - 1.2e-69 234.7 0.0 1.3e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34307.1 - 8.1e-30 104.0 0.0 1.2e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34307.1 - 2.3e-06 27.1 0.0 4e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CDF34307.1 - 0.0039 17.1 0.0 0.0066 16.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 CDF34307.1 - 0.011 15.4 0.0 0.64 9.6 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 CDF34307.1 - 0.015 14.9 0.0 0.021 14.4 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CDF34307.1 - 0.021 14.2 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family bZIP_2 PF07716.15 CDF34312.1 - 0.036 14.1 17.6 0.053 13.6 16.5 1.7 1 1 1 2 2 2 0 Basic region leucine zipper DUF4407 PF14362.6 CDF34312.1 - 0.058 12.7 2.6 0.087 12.2 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TSC22 PF01166.18 CDF34312.1 - 0.17 12.2 4.3 0.32 11.3 4.3 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family bZIP_Maf PF03131.17 CDF34312.1 - 0.25 11.9 11.6 0.45 11.1 11.6 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.21 CDF34312.1 - 0.28 11.3 18.0 0.5 10.5 18.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.15 CDF34312.1 - 1.7 8.5 7.5 3.9 7.3 7.5 1.6 1 0 0 1 1 1 0 Septum formation initiator ANAPC4_WD40 PF12894.7 CDF34313.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Spem1 PF15670.5 CDF34314.1 - 5.9 6.4 8.6 9.5 5.7 8.6 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 TraB PF01963.17 CDF34315.1 - 4.5e-10 39.9 0.0 8.8e-10 38.9 0.0 1.5 1 1 0 1 1 1 1 TraB family Pkinase PF00069.25 CDF34320.1 - 2.1e-72 243.7 0.0 2.4e-72 243.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34320.1 - 7.8e-36 123.7 0.0 9.4e-36 123.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34320.1 - 1.4e-11 44.2 0.0 5.5e-11 42.3 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 CDF34320.1 - 6.7e-05 22.3 0.3 0.00011 21.7 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF34320.1 - 0.00026 21.0 0.1 0.43 10.5 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 CDF34320.1 - 0.00036 20.2 0.1 0.00076 19.1 0.1 1.4 1 1 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CDF34320.1 - 0.0094 14.9 0.0 0.011 14.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CDF34320.1 - 0.023 14.3 0.0 0.042 13.5 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 TrmO_C PF18389.1 CDF34320.1 - 0.15 12.2 0.1 2.1 8.5 0.0 2.5 2 1 0 2 2 2 0 TrmO C-terminal domain Ribosomal_L13e PF01294.18 CDF34322.1 - 5.3e-74 248.0 3.0 5.3e-74 248.0 3.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L13e SAP PF02037.27 CDF34323.1 - 1.5e-11 43.7 1.4 3e-11 42.8 1.4 1.5 1 0 0 1 1 1 1 SAP domain RBM39linker PF15519.6 CDF34323.1 - 2.6 9.2 8.3 1.6 9.9 5.8 2.0 1 1 1 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Peptidase_M1 PF01433.20 CDF34324.1 - 1.3e-35 122.9 5.7 2.1e-35 122.3 5.7 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CDF34324.1 - 4e-17 63.0 0.0 7e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 CDF34324.1 - 9.4e-13 48.4 4.2 8.4e-06 26.1 0.3 4.6 2 2 3 5 5 5 5 HEAT repeats HEAT_PBS PF03130.16 CDF34324.1 - 0.0012 19.3 5.0 2.5 9.0 0.1 5.0 5 0 0 5 5 5 2 PBS lyase HEAT-like repeat TPR_MLP1_2 PF07926.12 CDF34324.1 - 0.0065 16.5 2.8 0.012 15.7 2.8 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 CDF34324.1 - 0.019 15.0 0.5 0.045 13.8 0.5 1.6 1 1 0 1 1 1 0 TolA binding protein trimerisation EMP24_GP25L PF01105.24 CDF34324.1 - 0.46 10.4 2.4 1.6 8.7 1.8 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Arf PF00025.21 CDF34326.1 - 2.5e-45 154.1 0.0 3e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDF34326.1 - 5.5e-12 45.5 0.0 6.7e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDF34326.1 - 5.7e-07 29.8 0.0 8.9e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDF34326.1 - 1.8e-06 27.4 0.1 0.0009 18.5 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CDF34326.1 - 5e-06 26.2 0.0 6.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CDF34326.1 - 0.00029 20.9 0.0 0.00046 20.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF34326.1 - 0.0076 15.6 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Peptidase_M20 PF01546.28 CDF34327.1 - 2.1e-34 119.1 0.0 3.1e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDF34327.1 - 1.6e-14 53.8 0.0 3.3e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CDF34329.1 - 1.6e-32 112.9 0.1 2.2e-32 112.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDF34329.1 - 1.2e-18 67.0 0.0 2.4e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain RRM_1 PF00076.22 CDF34330.1 - 8.1e-07 28.8 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HGTP_anticodon PF03129.20 CDF34330.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Anticodon binding domain UCH PF00443.29 CDF34331.1 - 5e-47 160.6 0.0 6.1e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF34331.1 - 1.2e-19 71.1 0.0 3.3e-19 69.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CDF34331.1 - 0.0068 15.9 4.3 2.9 7.3 0.0 2.9 2 1 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Zn-ribbon_8 PF09723.10 CDF34331.1 - 0.16 12.1 2.9 2.6 8.2 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain ADD_ATRX PF17981.1 CDF34331.1 - 0.32 10.9 3.4 0.4 10.6 0.1 2.4 2 0 0 2 2 2 0 Cysteine Rich ADD domain QWRF PF04484.12 CDF34331.1 - 1.4 8.6 5.1 2.7 7.6 5.1 1.4 1 0 0 1 1 1 0 QWRF family DNA_RNApol_7kD PF03604.13 CDF34331.1 - 9.4 6.0 7.1 5.9 6.7 0.2 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit HSP70 PF00012.20 CDF34333.1 - 5.3e-244 810.9 8.9 6.5e-244 810.6 8.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDF34333.1 - 9.8e-15 54.2 0.1 6.5e-13 48.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Fer4_24 PF18109.1 CDF34333.1 - 0.011 16.0 0.3 0.068 13.5 0.0 2.3 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain FtsA PF14450.6 CDF34333.1 - 0.017 15.5 3.1 0.58 10.6 0.1 3.2 3 2 0 3 3 3 0 Cell division protein FtsA Hydantoinase_A PF01968.18 CDF34333.1 - 0.028 13.7 0.2 0.46 9.7 0.1 2.4 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase FliJ PF02050.16 CDF34333.1 - 0.03 14.5 1.5 6.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein Spc7 PF08317.11 CDF34333.1 - 3.8 6.3 8.6 3.7 6.3 2.5 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein EMC3_TMCO1 PF01956.16 CDF34334.1 - 5.7e-19 68.5 0.0 7.5e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like SLATT_1 PF18181.1 CDF34334.1 - 0.073 13.0 0.3 0.16 11.9 0.1 1.7 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Tat PF00539.18 CDF34336.1 - 0.11 12.6 1.5 0.13 12.4 1.5 1.2 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) CAP160 PF07918.11 CDF34338.1 - 0.018 14.8 0.2 0.036 13.8 0.2 1.4 1 0 0 1 1 1 0 CAP160 repeat WD40 PF00400.32 CDF34339.1 - 1.9e-16 60.1 17.5 4.4e-07 30.5 3.6 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34339.1 - 7.1e-07 29.4 0.7 0.0041 17.4 0.1 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF34339.1 - 0.0029 16.6 0.0 12 4.7 0.0 3.3 3 0 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 CDF34339.1 - 0.0089 14.1 0.1 1.5 6.7 0.1 2.4 2 0 0 2 2 2 2 IKI3 family Pkinase_C PF00433.24 CDF34339.1 - 0.075 13.7 0.1 0.2 12.4 0.1 1.8 1 0 0 1 1 1 0 Protein kinase C terminal domain DEAD PF00270.29 CDF34340.1 - 1.1e-34 119.7 0.0 1.9e-34 119.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF34340.1 - 1.7e-21 76.6 0.0 3.7e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34340.1 - 0.0017 18.4 0.0 0.0059 16.6 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDF34340.1 - 0.0036 17.0 0.1 0.011 15.5 0.1 1.8 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 CDF34340.1 - 0.065 13.1 0.5 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Helicase Radical_SAM PF04055.21 CDF34341.1 - 1.1e-05 25.9 0.0 2.2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily CTP_transf_like PF01467.26 CDF34342.1 - 8.9e-09 35.7 0.0 1.4e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 CDF34342.1 - 0.013 15.4 0.3 0.062 13.2 0.0 2.0 2 0 0 2 2 2 0 FAD synthetase DDE_3 PF13358.6 CDF34343.1 - 7.8e-13 48.4 0.0 9.9e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_63 PF03200.16 CDF34347.1 - 1.8e-16 60.0 0.0 3.1e-11 42.7 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 63 C-terminal domain Integrase_H2C2 PF17921.1 CDF34348.1 - 4.2e-17 62.0 0.1 2.7e-16 59.4 0.1 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CDF34348.1 - 1.6e-08 34.8 0.1 0.00024 21.3 0.1 3.2 2 1 1 3 3 3 2 Integrase core domain RVT_1 PF00078.27 CDF34348.1 - 3.7e-08 33.2 0.0 0.0004 20.0 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CDF34348.1 - 1.5e-06 28.1 0.2 0.0021 18.0 0.0 2.5 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 CDF34348.1 - 7.3e-06 26.1 0.0 2e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH PF17917.1 CDF34348.1 - 0.0016 18.7 0.0 0.0043 17.3 0.0 1.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF34349.1 - 1.9e-11 44.2 0.0 1.7e-10 41.1 0.0 2.4 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF34349.1 - 0.00038 20.2 0.1 0.001 18.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Pkinase PF00069.25 CDF34350.1 - 1.1e-55 188.9 0.0 1.3e-55 188.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34350.1 - 2.4e-33 115.5 0.0 3.2e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34350.1 - 5.5e-06 25.9 0.0 1.2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Mcp5_PH PF12814.7 CDF34350.1 - 0.14 12.3 0.1 1.6 8.8 0.1 2.3 1 1 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Brix PF04427.18 CDF34351.1 - 9.6e-29 100.9 0.0 1.2e-28 100.6 0.0 1.1 1 0 0 1 1 1 1 Brix domain CDT1_C PF16679.5 CDF34351.1 - 0.023 15.1 0.7 13 6.3 0.0 3.2 4 0 0 4 4 4 0 DNA replication factor Cdt1 C-terminal domain DUF4128 PF13554.6 CDF34351.1 - 0.032 14.3 0.0 0.066 13.3 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function Radical_SAM PF04055.21 CDF34352.1 - 7.1e-17 62.3 0.0 1.2e-16 61.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CDF34352.1 - 5.8e-05 23.2 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 CDF34352.1 - 0.0092 16.3 0.1 0.021 15.1 0.1 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain RETICULATA-like PF11891.8 CDF34353.1 - 7.8e-56 188.7 0.2 1.1e-55 188.2 0.2 1.2 1 0 0 1 1 1 1 Protein RETICULATA-related VCBS PF13517.6 CDF34358.1 - 1.1e-10 41.9 1.3 2.2e-10 41.0 1.3 1.5 1 0 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.12 CDF34358.1 - 2.8e-09 36.8 2.1 4.7e-09 36.1 2.1 1.4 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.23 CDF34358.1 - 4.2e-05 23.6 2.8 0.0039 17.3 1.2 2.5 2 0 0 2 2 2 2 FG-GAP repeat EF-hand_6 PF13405.6 CDF34358.1 - 0.17 11.9 0.3 29 5.0 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 CDF34358.1 - 0.29 10.7 0.9 8.6 6.0 0.0 2.3 2 0 0 2 2 2 0 EF hand DUF2457 PF10446.9 CDF34360.1 - 0.54 9.3 4.6 0.71 9.0 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Corona_nucleoca PF00937.18 CDF34360.1 - 1.5 7.7 3.5 2.1 7.3 3.5 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein MPDZ_u10 PF16667.5 CDF34361.1 - 0.11 13.4 1.0 0.22 12.5 1.0 1.4 1 0 0 1 1 1 0 Unstructured region 10 on multiple PDZ protein GGACT PF06094.12 CDF34362.1 - 1.7e-19 70.6 0.1 2.5e-19 70.0 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like DUF1231 PF06802.11 CDF34362.1 - 0.038 13.1 0.0 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1231) PP2C PF00481.21 CDF34363.1 - 8.9e-08 32.1 0.1 0.014 15.0 0.0 2.7 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 CDF34363.1 - 5.3e-07 29.7 0.1 1.1e-06 28.7 0.0 1.5 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) TraB PF01963.17 CDF34365.1 - 0.026 14.4 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 TraB family DEAD PF00270.29 CDF34367.1 - 6.3e-33 114.0 0.0 9e-33 113.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF34367.1 - 2.4e-09 37.5 0.0 1.2e-08 35.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34367.1 - 3.7e-05 23.8 0.0 9e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDF34367.1 - 0.00025 21.3 0.0 0.002 18.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain SNF2_N PF00176.23 CDF34367.1 - 0.014 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain CMS1 PF14617.6 CDF34367.1 - 0.1 11.9 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit PHO4 PF01384.20 CDF34368.1 - 4.5e-117 390.9 29.9 5.2e-117 390.7 29.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family Cons_hypoth698 PF03601.14 CDF34368.1 - 0.0066 15.4 1.7 0.0066 15.4 1.7 3.3 1 1 2 3 3 3 1 Conserved hypothetical protein 698 HTH_IclR PF09339.10 CDF34368.1 - 0.029 14.2 0.2 6.7 6.6 0.1 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF5592 PF17332.2 CDF34368.1 - 4.6 7.9 7.7 5.6 7.6 0.5 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5592) Nup84_Nup100 PF04121.13 CDF34370.1 - 6.7e-69 232.8 0.0 1.9e-68 231.3 0.0 1.8 1 1 0 1 1 1 1 Nuclear pore protein 84 / 107 GLE1 PF07817.13 CDF34371.1 - 2e-28 99.3 0.1 2.3e-28 99.1 0.1 1.0 1 0 0 1 1 1 1 GLE1-like protein RMI2 PF16100.5 CDF34373.1 - 9.9e-17 61.0 0.0 1.2e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 CDC24_OB3 PF17244.2 CDF34373.1 - 0.017 14.8 0.0 0.019 14.7 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 UQ_con PF00179.26 CDF34375.1 - 1.3e-24 86.5 0.0 2e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CDF34375.1 - 0.0054 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 UEV domain DUF5526 PF17664.1 CDF34375.1 - 0.039 13.5 0.2 0.039 13.5 0.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5526) RWD PF05773.22 CDF34375.1 - 0.18 12.1 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 RWD domain PGM_PMM_II PF02879.16 CDF34376.1 - 5e-26 91.3 0.1 1.2e-25 90.1 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_I PF02878.16 CDF34376.1 - 3.1e-23 82.0 0.0 6.6e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDF34376.1 - 6e-13 49.0 0.1 9.7e-13 48.3 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Acyltransferase PF01553.21 CDF34377.1 - 0.21 11.2 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase F_actin_bind PF08919.10 CDF34378.1 - 0.003 17.6 0.9 0.012 15.7 0.1 2.0 2 0 0 2 2 2 1 F-actin binding CENP-K PF11802.8 CDF34378.1 - 0.015 14.8 1.3 0.018 14.6 1.3 1.2 1 0 0 1 1 1 0 Centromere-associated protein K THOC7 PF05615.13 CDF34378.1 - 0.02 15.2 11.5 0.096 13.0 4.9 2.2 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4140 PF13600.6 CDF34378.1 - 0.026 14.9 4.0 0.026 14.9 4.0 2.3 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Exonuc_VII_L PF02601.15 CDF34378.1 - 0.057 13.0 4.2 0.073 12.6 4.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5345 PF17280.2 CDF34378.1 - 0.11 12.5 3.1 0.59 10.1 0.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5345) AphA_like PF14557.6 CDF34378.1 - 0.12 12.1 3.7 0.1 12.3 0.7 2.0 1 1 1 2 2 2 0 Putative AphA-like transcriptional regulator DUF1993 PF09351.10 CDF34378.1 - 0.24 11.6 2.9 0.85 9.7 2.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) APG6_N PF17675.1 CDF34378.1 - 0.8 10.2 12.3 42 4.7 11.5 2.5 1 1 0 1 1 1 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 CDF34378.1 - 1.3 9.2 10.7 0.56 10.5 2.2 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ABC_tran_CTD PF16326.5 CDF34378.1 - 1.5 9.2 12.4 2.2 8.6 3.3 3.3 2 1 1 3 3 3 0 ABC transporter C-terminal domain Lzipper-MIP1 PF14389.6 CDF34378.1 - 2.3 8.6 10.0 7.3 7.0 9.0 2.4 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DivIC PF04977.15 CDF34378.1 - 3.1 7.6 7.4 0.73 9.6 0.7 2.8 3 0 0 3 3 3 0 Septum formation initiator Spc24 PF08286.11 CDF34378.1 - 6.2 7.1 7.0 30 4.9 0.3 2.6 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 FtsX PF02687.21 CDF34379.1 - 2.9e-16 59.7 11.6 4.8e-10 39.8 2.6 5.6 5 0 0 5 5 5 2 FtsX-like permease family DnaJ-X PF14308.6 CDF34380.1 - 4.8e-25 88.3 0.1 1.6e-24 86.5 0.1 1.8 1 1 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 CDF34380.1 - 4.6e-24 84.3 2.1 4.6e-24 84.3 2.1 2.2 2 0 0 2 2 2 1 DnaJ domain DEC-1_N PF04625.13 CDF34380.1 - 0.0081 15.2 1.3 0.012 14.6 1.3 1.3 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region Peptidase_C1_2 PF03051.15 CDF34380.1 - 0.03 13.1 0.1 0.046 12.5 0.1 1.2 1 0 0 1 1 1 0 Peptidase C1-like family ATG_C PF09333.11 CDF34380.1 - 0.067 13.6 0.1 0.43 11.0 0.0 2.4 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain zf-CHY PF05495.12 CDF34382.1 - 2.1e-13 50.5 17.4 2.1e-13 50.5 17.4 2.5 2 0 0 2 2 2 1 CHY zinc finger Pkinase PF00069.25 CDF34384.1 - 7.1e-68 228.8 0.0 1.1e-67 228.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34384.1 - 3.5e-39 134.7 0.0 6.8e-39 133.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34384.1 - 3.5e-09 36.4 0.1 2.7e-06 26.9 0.0 3.0 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 CDF34384.1 - 1.4e-05 25.2 0.9 0.041 13.8 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDF34384.1 - 0.0049 15.9 0.0 0.0074 15.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain DUF2232 PF09991.9 CDF34385.1 - 1.3e-07 31.1 10.3 2e-07 30.5 10.3 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) DUF3290 PF11694.8 CDF34385.1 - 1.6 8.7 4.0 3.1 7.7 0.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3290) NB-ARC PF00931.22 CDF34386.1 - 9.2e-16 57.8 0.0 4.8e-15 55.4 0.0 2.0 2 1 0 2 2 2 1 NB-ARC domain WD40 PF00400.32 CDF34386.1 - 7.4e-06 26.6 4.3 0.0065 17.3 0.1 4.7 4 1 0 4 4 4 2 WD domain, G-beta repeat AAA_16 PF13191.6 CDF34386.1 - 0.02 15.3 0.1 0.077 13.4 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain APAF1_C PF17908.1 CDF34386.1 - 0.03 14.3 0.0 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain Abhydrolase_1 PF00561.20 CDF34387.1 - 4e-12 46.3 0.0 9.1e-11 41.9 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF34387.1 - 8.1e-10 39.7 0.7 8.1e-10 39.7 0.7 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF34387.1 - 1e-08 34.8 0.0 2e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 CDF34387.1 - 0.026 14.1 0.0 4.2 6.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family PhoPQ_related PF10142.9 CDF34387.1 - 0.048 12.3 0.0 0.072 11.7 0.0 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Ser_hydrolase PF06821.13 CDF34387.1 - 0.066 13.1 0.0 7 6.5 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase Y_phosphatase PF00102.27 CDF34388.1 - 2.1e-56 191.2 0.0 1e-55 188.9 0.0 1.9 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDF34388.1 - 0.0089 16.0 0.1 0.031 14.2 0.1 1.9 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CDF34388.1 - 0.13 12.4 0.0 0.56 10.3 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate DSPc PF00782.20 CDF34388.1 - 0.13 12.0 0.1 0.37 10.6 0.1 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Chorismate_bind PF00425.18 CDF34389.1 - 2.9e-85 285.9 0.0 5.3e-85 285.1 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CDF34389.1 - 5.8e-27 94.6 0.0 2e-24 86.4 0.0 2.4 2 0 0 2 2 2 2 Anthranilate synthase component I, N terminal region Amino_oxidase PF01593.24 CDF34390.1 - 5.7e-18 65.4 0.0 1.7e-17 63.9 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF34390.1 - 7.2e-12 45.4 0.1 1.6e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF34390.1 - 1.9e-08 34.3 2.8 5.5e-05 22.9 1.5 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF34390.1 - 0.00089 18.6 0.3 0.0023 17.2 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF34390.1 - 0.0011 18.1 1.4 0.0018 17.4 1.4 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CDF34390.1 - 0.0017 17.1 0.1 0.0055 15.4 0.3 1.6 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 CDF34390.1 - 0.0033 17.4 0.6 3.8 7.5 0.0 2.8 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 CDF34390.1 - 0.022 14.0 0.2 0.037 13.3 0.2 1.3 1 0 0 1 1 1 0 Thi4 family ACT_7 PF13840.6 CDF34390.1 - 0.052 13.3 0.4 17 5.3 0.1 3.1 3 0 0 3 3 3 0 ACT domain GIDA PF01134.22 CDF34390.1 - 0.058 12.5 0.9 0.097 11.7 0.9 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CDF34390.1 - 0.25 10.6 0.3 0.54 9.5 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CDF34390.1 - 0.35 11.5 1.0 0.8 10.3 0.2 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UvrB PF12344.8 CDF34393.1 - 3.9e-15 55.4 0.4 1.1e-14 54.0 0.4 1.7 1 0 0 1 1 1 1 Ultra-violet resistance protein B UvrB_inter PF17757.1 CDF34393.1 - 4.3e-11 42.8 0.0 4.6e-10 39.5 0.0 2.6 2 0 0 2 2 2 1 UvrB interaction domain Helicase_C PF00271.31 CDF34393.1 - 5.6e-10 39.5 0.0 1.3e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34393.1 - 1.1e-08 35.3 0.0 7e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UVR PF02151.19 CDF34393.1 - 7.5e-06 25.5 0.5 2e-05 24.2 0.5 1.7 1 0 0 1 1 1 1 UvrB/uvrC motif AAA_30 PF13604.6 CDF34393.1 - 7.6e-05 22.5 0.2 0.0005 19.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 CDF34393.1 - 0.00019 21.2 0.0 0.00083 19.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDF34393.1 - 0.023 15.0 0.0 0.074 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDF34393.1 - 0.13 11.4 0.0 0.53 9.4 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain Kinesin PF00225.23 CDF34393.1 - 0.13 11.1 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinesin motor domain Coprogen_oxidas PF01218.18 CDF34394.1 - 4.8e-96 321.0 0.0 6.5e-96 320.5 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Tat PF00539.18 CDF34394.1 - 0.033 14.4 0.2 0.08 13.1 0.2 1.6 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) Epiglycanin_C PF14654.6 CDF34394.1 - 0.041 13.9 0.1 0.079 13.0 0.1 1.4 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region RNB PF00773.19 CDF34395.1 - 1.9e-47 162.2 0.0 1.1e-45 156.4 0.0 2.3 1 1 0 1 1 1 1 RNB domain PEMT PF04191.13 CDF34397.1 - 2.2e-23 82.6 0.3 3.5e-23 82.0 0.3 1.3 1 0 0 1 1 1 1 Phospholipid methyltransferase EptA_B_N PF08019.12 CDF34397.1 - 0.12 12.2 0.3 0.36 10.7 0.2 1.8 1 1 1 2 2 2 0 Phosphoethanolamine transferase EptA/EptB DUF4040 PF13244.6 CDF34397.1 - 0.28 11.4 0.2 0.28 11.4 0.2 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4040) NUDIX PF00293.28 CDF34398.1 - 4.5e-06 26.7 0.5 2.5e-05 24.3 0.2 2.1 2 1 0 2 2 2 1 NUDIX domain IBR PF01485.21 CDF34407.1 - 0.003 17.7 4.6 0.0073 16.5 4.6 1.6 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zf-B_box PF00643.24 CDF34407.1 - 0.3 11.3 4.6 0.1 12.8 1.2 1.9 2 0 0 2 2 2 0 B-box zinc finger BRK PF07533.16 CDF34409.1 - 5e-14 51.6 0.1 2.2e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 BRK domain Band_7 PF01145.25 CDF34410.1 - 2.8e-14 53.5 0.0 3.6e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CDF34410.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 SPFH domain-Band 7 family Mfa_like_2 PF15415.6 CDF34411.1 - 0.089 11.7 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Fimbrillin-like Hint PF01079.20 CDF34414.1 - 2.6e-27 95.8 0.8 6.5e-27 94.4 0.8 1.6 1 1 0 1 1 1 1 Hint module Vint PF14623.6 CDF34414.1 - 0.0025 17.6 0.4 0.33 10.7 0.0 2.3 1 1 1 2 2 2 2 Hint-domain Hom_end_hint PF05203.16 CDF34414.1 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Hom_end-associated Hint Hint_2 PF13403.6 CDF34414.1 - 0.017 15.5 0.3 0.048 14.0 0.3 2.0 1 1 0 1 1 1 0 Hint domain Hydrolase_4 PF12146.8 CDF34415.1 - 4.2e-20 72.0 1.3 2.8e-13 49.7 0.1 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF34415.1 - 5.1e-11 42.7 2.0 6.1e-08 32.6 0.1 3.2 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF34415.1 - 1.4e-09 38.9 1.0 3.9e-09 37.4 1.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CDF34415.1 - 1.8e-06 27.9 0.0 0.014 15.2 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase TPR_2 PF07719.17 CDF34415.1 - 8.2e-06 25.5 0.0 0.28 11.4 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Peptidase_S9 PF00326.21 CDF34415.1 - 0.00012 21.6 0.1 0.0015 18.1 0.1 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 CDF34415.1 - 0.00024 19.9 0.0 0.31 9.7 0.0 2.3 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) TPR_1 PF00515.28 CDF34415.1 - 0.0004 20.1 0.0 0.73 9.8 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Lipase_3 PF01764.25 CDF34415.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) FSH1 PF03959.13 CDF34415.1 - 0.0027 17.4 0.0 0.0056 16.4 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 CDF34415.1 - 0.0037 17.3 0.0 0.0097 16.0 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Chlorophyllase2 PF12740.7 CDF34415.1 - 0.0052 15.7 0.2 0.015 14.2 0.0 1.8 2 0 0 2 2 2 1 Chlorophyllase enzyme Peptidase_S15 PF02129.18 CDF34415.1 - 0.0077 15.9 0.1 0.066 12.8 0.0 2.4 3 0 0 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) DUF915 PF06028.11 CDF34415.1 - 0.029 13.7 0.0 0.072 12.4 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) PAF-AH_p_II PF03403.13 CDF34415.1 - 0.045 12.3 0.5 0.41 9.1 0.0 2.5 3 0 0 3 3 3 0 Platelet-activating factor acetylhydrolase, isoform II DUF1749 PF08538.10 CDF34415.1 - 0.073 12.1 0.0 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) FlgN PF05130.12 CDF34415.1 - 0.11 13.0 0.9 0.19 12.2 0.9 1.4 1 0 0 1 1 1 0 FlgN protein LIDHydrolase PF10230.9 CDF34415.1 - 0.17 11.4 0.1 11 5.5 0.0 2.2 1 1 0 2 2 2 0 Lipid-droplet associated hydrolase TPR_17 PF13431.6 CDF34415.1 - 0.19 12.2 0.0 0.51 10.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat UPF0139 PF03669.13 CDF34416.1 - 2.7e-15 56.0 1.0 3e-15 55.9 1.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) PAP2 PF01569.21 CDF34418.1 - 0.0014 18.4 0.6 0.011 15.5 0.6 2.1 1 1 0 1 1 1 1 PAP2 superfamily Keratin_2_head PF16208.5 CDF34420.1 - 0.057 13.6 9.8 0.08 13.1 9.8 1.2 1 0 0 1 1 1 0 Keratin type II head Sporozoite_P67 PF05642.11 CDF34420.1 - 0.42 8.6 2.8 0.48 8.4 2.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Keratin_B2 PF01500.17 CDF34420.1 - 0.46 10.5 4.6 0.74 9.8 4.6 1.3 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein Pkinase PF00069.25 CDF34421.1 - 5.6e-13 48.9 0.0 6.3e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDF34421.1 - 1.2e-06 27.6 0.0 1.6e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 CDF34421.1 - 4.3e-05 22.9 0.0 5.9e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF34421.1 - 0.0018 18.2 0.0 0.0039 17.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF34421.1 - 0.0057 16.0 0.0 0.014 14.8 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDF34421.1 - 0.17 11.4 0.1 0.35 10.4 0.0 1.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.25 CDF34425.1 - 1.9e-13 50.4 0.0 2.1e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDF34425.1 - 2.1e-06 26.8 0.0 2.9e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 CDF34425.1 - 1.4e-05 24.5 0.0 1.8e-05 24.2 0.0 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF34425.1 - 0.01 15.2 0.1 0.025 13.9 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF34425.1 - 0.054 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-C2H2_4 PF13894.6 CDF34427.1 - 1.6e-14 53.4 24.5 0.0021 18.7 0.2 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 CDF34427.1 - 6.2e-13 48.4 25.1 0.0035 17.7 0.3 6.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type GAGA PF09237.11 CDF34427.1 - 3.9e-07 29.8 4.9 0.036 13.9 0.0 4.1 2 1 1 3 3 3 2 GAGA factor zf-C2H2_jaz PF12171.8 CDF34427.1 - 2.2e-06 27.8 2.9 0.1 12.9 0.1 4.3 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 CDF34427.1 - 3.1e-05 24.2 3.1 0.00042 20.6 0.6 7.0 8 0 0 8 8 6 3 Zinc-finger double domain zf-met PF12874.7 CDF34427.1 - 0.00087 19.6 16.9 0.63 10.5 0.4 4.9 5 0 0 5 5 5 3 Zinc-finger of C2H2 type RskA PF10099.9 CDF34427.1 - 0.011 16.1 10.9 0.011 16.1 10.9 4.7 1 1 2 4 4 2 0 Anti-sigma-K factor rskA zf-C2H2_6 PF13912.6 CDF34427.1 - 0.012 15.6 22.1 0.5 10.4 0.1 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CDF34427.1 - 0.013 15.8 8.6 1.4 9.2 2.0 3.2 2 0 0 2 2 2 0 C2H2-type zinc ribbon DZR PF12773.7 CDF34427.1 - 0.019 15.0 2.2 0.019 15.0 2.2 3.1 3 0 0 3 3 3 0 Double zinc ribbon zf-C2H2_11 PF16622.5 CDF34427.1 - 0.045 13.5 24.4 0.14 12.0 3.5 4.7 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 CDF34427.1 - 0.13 12.1 16.9 0.87 9.4 0.8 4.5 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 CDF34427.1 - 0.31 10.7 18.0 0.38 10.4 2.9 5.1 2 2 3 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-MYST PF17772.1 CDF34427.1 - 2.3 7.9 9.1 0.56 9.9 0.1 3.8 4 0 0 4 4 4 0 MYST family zinc finger domain WLM PF08325.10 CDF34428.1 - 4.1e-31 108.5 0.0 8.6e-31 107.5 0.0 1.5 1 1 0 1 1 1 1 WLM domain PUB PF09409.10 CDF34428.1 - 2.6e-11 43.3 0.0 2.2e-10 40.3 0.0 2.1 2 0 0 2 2 2 1 PUB domain DUF45 PF01863.17 CDF34428.1 - 0.00019 21.5 0.1 0.00048 20.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF45 UBA PF00627.31 CDF34428.1 - 0.025 14.5 0.1 0.025 14.5 0.1 2.6 3 0 0 3 3 3 0 UBA/TS-N domain SprT-like PF10263.9 CDF34428.1 - 0.041 13.7 0.0 0.09 12.6 0.0 1.6 1 0 0 1 1 1 0 SprT-like family VPS11_C PF12451.8 CDF34429.1 - 1.3e-07 31.7 1.4 1.8e-07 31.3 0.2 1.9 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 CDF34429.1 - 0.011 15.7 4.7 0.011 15.7 4.7 2.9 3 0 0 3 3 3 0 Zinc-finger zf-C3HC4_2 PF13923.6 CDF34429.1 - 0.26 11.2 7.0 0.034 14.0 1.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF34429.1 - 5.8 7.3 6.6 1.2 9.5 2.4 2.1 2 0 0 2 2 2 0 Ring finger domain PseudoU_synth_2 PF00849.22 CDF34430.1 - 3.5e-26 92.2 0.0 5e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Pkinase PF00069.25 CDF34432.1 - 2e-77 260.1 0.0 2.6e-77 259.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34432.1 - 1e-43 149.5 0.0 1.4e-43 149.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34432.1 - 8.5e-09 35.1 0.5 0.00022 20.6 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CDF34432.1 - 7.4e-06 25.0 0.0 1.1e-05 24.4 0.0 1.3 1 1 0 1 1 1 1 Fungal protein kinase PH PF00169.29 CDF34432.1 - 9.7e-06 26.1 0.1 2.2e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CDF34432.1 - 0.0069 16.7 0.0 0.018 15.3 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 CDF34432.1 - 0.03 14.7 0.0 0.073 13.4 0.0 1.7 1 0 0 1 1 1 0 Plant pleckstrin homology-like region APH PF01636.23 CDF34432.1 - 0.047 13.6 0.0 3.4 7.5 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CDF34432.1 - 0.049 13.0 0.1 0.1 11.9 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FHA PF00498.26 CDF34434.1 - 6.4e-07 29.6 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain BRCT PF00533.26 CDF34434.1 - 2.7e-05 24.4 0.0 0.032 14.6 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PUF PF00806.19 CDF34436.1 - 2.8e-06 26.7 0.0 0.082 12.6 0.0 4.2 4 0 0 4 4 4 2 Pumilio-family RNA binding repeat DUF2151 PF10221.9 CDF34436.1 - 1.9 7.0 16.8 33 2.9 19.7 1.6 2 0 0 2 2 2 0 Cell cycle and development regulator GAGA_bind PF06217.12 CDF34436.1 - 3.9 7.7 25.2 0.015 15.6 12.8 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family NAD_kinase PF01513.21 CDF34439.1 - 1.2e-58 198.6 0.0 2e-58 197.9 0.0 1.4 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 CDF34439.1 - 0.0027 17.3 0.0 0.0047 16.5 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain TetR_C_9 PF14514.6 CDF34440.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HTH_psq PF05225.16 CDF34440.1 - 0.17 11.7 0.1 0.61 9.9 0.1 2.0 1 1 0 1 1 1 0 helix-turn-helix, Psq domain PLD_C PF12357.8 CDF34441.1 - 1.4e-19 69.7 0.0 2.5e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Phospholipase D C terminal C2 PF00168.30 CDF34441.1 - 2.4e-08 34.2 0.0 4.4e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain PLDc PF00614.22 CDF34441.1 - 3e-08 33.5 0.0 0.0009 19.3 0.0 2.9 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CDF34441.1 - 3.9e-05 23.5 0.0 0.0015 18.4 0.0 2.8 3 0 0 3 3 3 1 PLD-like domain Plant_tran PF04827.14 CDF34444.1 - 1.6e-64 217.3 0.1 8e-61 205.2 0.0 2.8 2 1 1 3 3 3 2 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF34444.1 - 4.4e-11 42.7 0.0 6.9e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease BP28CT PF08146.12 CDF34445.1 - 1.3e-14 54.3 0.1 9.9e-14 51.5 0.0 2.3 2 0 0 2 2 2 1 BP28CT (NUC211) domain HEAT_2 PF13646.6 CDF34445.1 - 0.0001 22.6 5.2 0.35 11.3 0.0 6.0 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 CDF34445.1 - 0.12 12.9 0.5 6.5 7.4 0.0 4.0 3 0 0 3 3 3 0 HEAT-like repeat Nexin_C PF08628.12 CDF34445.1 - 0.12 12.9 0.0 0.59 10.7 0.0 2.2 1 0 0 1 1 1 0 Sorting nexin C terminal RF-1 PF00472.20 CDF34447.1 - 8.8e-26 90.1 2.5 1.3e-25 89.6 2.5 1.2 1 0 0 1 1 1 1 RF-1 domain Adaptin_N PF01602.20 CDF34449.1 - 1e-85 288.4 0.6 1.8e-85 287.5 0.6 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 CDF34449.1 - 1.7e-53 180.0 0.0 4.8e-53 178.5 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 CDF34449.1 - 1.7e-51 173.8 0.2 3.6e-51 172.8 0.2 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_g_Cpla PF16381.5 CDF34449.1 - 6.2e-06 26.3 0.0 7.4e-05 22.9 0.0 2.7 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 CDF34449.1 - 0.0001 22.2 0.1 0.075 13.3 0.0 4.2 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.7 CDF34449.1 - 0.00021 21.4 1.9 0.013 15.6 0.0 3.2 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDF34449.1 - 0.00034 20.9 2.4 0.88 10.0 0.0 4.5 3 2 1 4 4 4 1 HEAT repeats PAS_6 PF08348.11 CDF34453.1 - 0.094 12.6 0.2 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 YheO-like PAS domain FliD_C PF07195.12 CDF34454.1 - 0.083 12.3 5.2 0.63 9.4 0.4 2.4 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus COG2 PF06148.11 CDF34454.1 - 0.19 11.8 3.2 2.9 8.0 0.3 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 LMBR1 PF04791.16 CDF34454.1 - 1.8 7.4 2.4 2.4 6.9 2.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein End3 PF12761.7 CDF34454.1 - 6.3 6.9 22.7 0.5 10.5 0.2 3.3 3 0 0 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 TMPIT PF07851.13 CDF34454.1 - 7.6 5.7 5.5 15 4.7 0.1 2.2 2 0 0 2 2 2 0 TMPIT-like protein UPF0242 PF06785.11 CDF34454.1 - 9.4 6.3 12.5 0.69 10.0 6.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Integrin_beta PF00362.18 CDF34456.1 - 5e-07 29.6 0.0 0.0053 16.5 0.0 2.1 1 1 1 2 2 2 2 Integrin beta chain VWA domain TraW_N PF12477.8 CDF34456.1 - 2.2 8.3 5.4 4.1 7.5 1.1 2.6 2 0 0 2 2 2 0 Sex factor F TraW protein N terminal rve PF00665.26 CDF34458.1 - 1.9e-22 79.7 0.0 3.5e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_38 PF13936.6 CDF34458.1 - 0.00011 21.8 2.8 0.00069 19.3 0.6 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain rve_3 PF13683.6 CDF34458.1 - 0.0016 18.2 0.0 0.0039 16.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain IstB_IS21 PF01695.17 CDF34459.1 - 2.7e-54 183.6 0.0 4e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CDF34459.1 - 3.6e-06 27.5 0.3 9.1e-06 26.1 0.1 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDF34459.1 - 7e-05 23.1 0.3 0.00032 21.0 0.1 2.2 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CDF34459.1 - 0.00018 21.3 0.0 0.00028 20.6 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain Bac_DnaA PF00308.18 CDF34459.1 - 0.00025 20.9 0.0 0.00042 20.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein AAA_7 PF12775.7 CDF34459.1 - 0.0025 17.4 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 CDF34459.1 - 0.0079 16.3 0.1 0.042 13.9 0.1 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_25 PF13481.6 CDF34459.1 - 0.0086 15.7 0.0 0.014 14.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CDF34459.1 - 0.011 16.1 0.0 0.037 14.4 0.0 2.0 1 1 0 1 1 1 0 RNA helicase AAA PF00004.29 CDF34459.1 - 0.013 15.9 0.0 0.024 15.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDF34459.1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CDF34459.1 - 0.014 15.9 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDF34459.1 - 0.015 15.3 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDF34459.1 - 0.016 15.4 0.1 0.016 15.4 0.1 1.9 2 1 0 2 2 1 0 AAA domain AAA_28 PF13521.6 CDF34459.1 - 0.022 15.0 0.5 0.046 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDF34459.1 - 0.022 14.7 1.1 0.13 12.2 0.3 2.5 2 1 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CDF34459.1 - 0.032 14.0 0.1 0.054 13.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDF34459.1 - 0.04 13.7 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 CDF34459.1 - 0.041 14.4 0.0 0.077 13.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 CDF34459.1 - 0.05 13.0 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 CDF34459.1 - 0.053 13.2 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDF34459.1 - 0.063 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 CDF34459.1 - 0.084 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Guanylate kinase PTS_IIB PF02302.17 CDF34459.1 - 0.15 12.8 0.0 0.3 11.8 0.0 1.5 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIB subunit ATPase PF06745.13 CDF34459.1 - 0.22 10.8 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 KaiC rve PF00665.26 CDF34460.1 - 2.3e-31 108.5 0.0 3.6e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_2 PF13333.6 CDF34460.1 - 7e-14 51.7 0.9 1.2e-13 51.0 0.9 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF34460.1 - 1.6e-11 43.8 0.1 3e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_21 PF13276.6 CDF34460.1 - 2.3e-09 37.2 3.3 5.6e-09 36.0 0.5 2.4 2 0 0 2 2 2 1 HTH-like domain DDE_Tnp_IS240 PF13610.6 CDF34460.1 - 6.2e-06 26.5 0.1 1e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 DDE domain DDE_Tnp_IS66 PF03050.14 CDF34461.1 - 0.012 15.1 0.0 0.013 15.0 0.0 1.0 1 0 0 1 1 1 0 Transposase IS66 family HTH_28 PF13518.6 CDF34461.1 - 0.051 13.7 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_32 PF13565.6 CDF34461.1 - 0.088 13.4 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain HTH_48 PF17906.1 CDF34461.1 - 0.094 12.9 0.1 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 HTH domain in Mos1 transposase DUF3376 PF11856.8 CDF34462.1 - 4.1e-45 154.7 8.3 1.1e-43 150.0 8.4 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3376) Patatin PF01734.22 CDF34462.1 - 2.4e-13 50.8 0.1 1.3e-12 48.4 0.0 2.2 2 0 0 2 2 2 1 Patatin-like phospholipase AAA_16 PF13191.6 CDF34464.1 - 1.5e-20 74.3 0.5 8.6e-20 71.8 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain Guanylate_cyc PF00211.20 CDF34464.1 - 7e-15 55.1 0.0 3.6e-13 49.5 0.0 2.3 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain TPR_MalT PF17874.1 CDF34464.1 - 4.9e-08 32.7 24.4 0.00021 20.8 2.9 3.6 2 1 1 4 4 4 3 MalT-like TPR region TPR_2 PF07719.17 CDF34464.1 - 1.1e-05 25.1 16.8 0.26 11.5 1.7 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat AAA_22 PF13401.6 CDF34464.1 - 1.6e-05 25.2 0.0 7.4e-05 23.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain TPR_12 PF13424.6 CDF34464.1 - 4.3e-05 23.7 31.8 0.57 10.5 1.0 7.3 4 3 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDF34464.1 - 0.0014 18.7 6.9 3.8 8.0 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat ATPase_2 PF01637.18 CDF34464.1 - 0.034 14.1 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 CDF34464.1 - 0.088 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 CDF34464.1 - 0.11 12.5 0.0 0.4 10.7 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MFS_2 PF13347.6 CDF34464.1 - 0.15 10.6 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein TPR_1 PF00515.28 CDF34464.1 - 0.16 11.9 4.2 24 5.0 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF34464.1 - 0.2 12.5 0.1 0.2 12.5 0.1 9.0 7 2 3 10 10 10 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDF34464.1 - 0.26 12.0 30.3 3.1 8.7 0.9 8.8 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDF34464.1 - 0.35 10.8 0.0 0.35 10.8 0.0 5.6 8 0 0 8 8 7 0 Tetratricopeptide repeat HTH_Crp_2 PF13545.6 CDF34465.1 - 3.5e-11 42.9 0.3 6.9e-11 42.0 0.3 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Crp PF00325.20 CDF34465.1 - 1.2e-06 28.1 0.0 2.1e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family GntR PF00392.21 CDF34465.1 - 0.00027 20.5 0.2 0.00075 19.1 0.2 1.8 1 1 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_46 PF15977.5 CDF34465.1 - 0.00029 20.8 0.1 0.00056 19.9 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA binding TrmB PF01978.19 CDF34465.1 - 0.00065 19.5 0.1 0.0013 18.5 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 CDF34465.1 - 0.003 17.9 0.1 0.0089 16.3 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulator HTH_23 PF13384.6 CDF34465.1 - 0.011 15.5 2.5 0.24 11.2 0.0 2.8 2 1 1 3 3 3 0 Homeodomain-like domain HTH_CodY PF08222.11 CDF34465.1 - 0.012 15.2 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain MarR PF01047.22 CDF34465.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 MarR family cNMP_binding PF00027.29 CDF34465.1 - 0.018 15.1 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain Sigma70_r4 PF04545.16 CDF34465.1 - 0.019 14.4 0.1 0.14 11.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_24 PF13412.6 CDF34465.1 - 0.039 13.5 0.0 0.13 11.9 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Il2rg PF15874.5 CDF34465.1 - 0.12 12.7 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative Interleukin 2 receptor, gamma chain Trp_repressor PF01371.19 CDF34465.1 - 0.15 12.2 1.2 0.5 10.5 0.0 2.3 3 0 0 3 3 3 0 Trp repressor protein TPR_14 PF13428.6 CDF34466.1 - 0.036 14.9 0.8 0.048 14.5 0.8 1.4 1 1 0 1 1 1 0 Tetratricopeptide repeat PIN_3 PF13470.6 CDF34467.1 - 1.7e-21 77.2 0.0 2.1e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 PIN domain PIN PF01850.21 CDF34467.1 - 0.033 14.7 0.2 0.2 12.2 0.2 2.1 1 1 0 1 1 1 0 PIN domain ParD PF09386.10 CDF34468.1 - 0.0001 22.6 0.1 0.00015 22.1 0.1 1.3 1 1 0 1 1 1 1 Antitoxin ParD HicB PF05534.12 CDF34468.1 - 0.00073 19.3 0.2 0.0042 16.9 0.0 2.0 2 0 0 2 2 2 1 HicB family DUF1778 PF08681.11 CDF34468.1 - 0.013 15.4 0.1 0.028 14.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1778) RHH_1 PF01402.21 CDF34468.1 - 0.017 15.0 0.1 0.045 13.7 0.1 1.7 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family RHH_5 PF07878.11 CDF34468.1 - 0.043 13.7 0.2 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 DUF1471 PF07338.13 CDF34468.1 - 0.068 13.2 0.1 15 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) DUF900 PF05990.12 CDF34469.1 - 0.023 14.2 0.0 0.023 14.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF4609 PF15382.6 CDF34469.1 - 0.073 13.0 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) Phage_DsbA PF11126.8 CDF34469.1 - 0.13 12.5 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator DsbA Peptidase_S8 PF00082.22 CDF34470.1 - 2e-40 138.9 0.7 2e-40 138.9 0.7 1.7 2 0 0 2 2 2 1 Subtilase family CMAS PF02353.20 CDF34472.1 - 1.5e-90 303.2 0.1 1.9e-90 302.9 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CDF34472.1 - 2.1e-12 47.6 0.0 5.4e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF34472.1 - 1.8e-11 44.6 0.1 3.9e-11 43.4 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF34472.1 - 1.8e-10 40.9 0.0 2.8e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF34472.1 - 3.5e-07 30.2 0.1 2.2e-06 27.5 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF34472.1 - 1e-06 29.4 0.1 2.8e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDF34472.1 - 0.0067 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CDF34472.1 - 0.028 14.2 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 CDF34472.1 - 0.035 13.7 0.1 0.07 12.7 0.1 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DOT1 PF08123.13 CDF34472.1 - 0.039 13.5 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 FtsJ PF01728.19 CDF34472.1 - 0.055 13.6 0.0 0.095 12.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 CDF34472.1 - 0.064 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NT5C PF06941.12 CDF34473.1 - 4.5e-11 43.0 0.1 1.8e-09 37.7 0.0 2.0 1 1 1 2 2 2 2 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Methyltransf_PK PF05891.12 CDF34473.1 - 0.029 13.9 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase HD_4 PF13328.6 CDF34474.1 - 5.9e-20 71.6 0.0 8.6e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 HD domain HD PF01966.22 CDF34474.1 - 0.0011 19.2 0.2 0.0052 17.0 0.0 2.0 2 0 0 2 2 2 1 HD domain RNA_lig_T4_1 PF09511.10 CDF34474.1 - 0.065 13.1 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA ligase HyaE PF07449.11 CDF34474.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE FANC_SAP PF18081.1 CDF34474.1 - 0.12 12.6 0.5 0.8 9.9 0.0 2.2 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain AAA_PrkA PF08298.11 CDF34475.1 - 1.6e-40 139.1 0.0 1.8e-40 139.0 0.0 1.0 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 CDF34475.1 - 0.0099 16.3 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AFG1_ATPase PF03969.16 CDF34475.1 - 0.015 14.2 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 AFG1-like ATPase AAA_22 PF13401.6 CDF34475.1 - 0.072 13.4 0.0 0.089 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDF34475.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDF34475.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Resolvase PF00239.21 CDF34476.1 - 3.2e-43 147.3 0.0 4.5e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 Resolvase, N terminal domain HTH_38 PF13936.6 CDF34476.1 - 0.0091 15.7 0.1 0.019 14.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_8 PF02954.19 CDF34476.1 - 0.046 13.5 0.3 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_30 PF13556.6 CDF34476.1 - 0.068 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DUF2384 PF09722.10 CDF34477.1 - 0.039 14.0 0.1 0.1 12.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) PIN_3 PF13470.6 CDF34478.1 - 5.8e-18 65.7 0.1 7e-18 65.5 0.1 1.1 1 0 0 1 1 1 1 PIN domain PIN PF01850.21 CDF34478.1 - 6.9e-05 23.3 0.1 8.9e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 PIN domain RHH_1 PF01402.21 CDF34479.1 - 1.3e-06 28.1 1.1 2.2e-06 27.4 1.1 1.4 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family RHH_5 PF07878.11 CDF34479.1 - 0.003 17.4 0.4 0.003 17.4 0.4 1.6 2 0 0 2 2 2 1 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 Cas_APE2256 PF09651.10 CDF34479.1 - 0.071 13.0 0.0 0.078 12.9 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) TraY PF05509.11 CDF34479.1 - 0.17 11.9 1.3 0.25 11.4 1.0 1.7 1 1 0 1 1 1 0 TraY domain DUF3701 PF12482.8 CDF34480.1 - 1.5e-21 76.2 0.3 1.5e-21 76.2 0.3 3.2 4 0 0 4 4 4 1 Phage integrase protein Phage_integrase PF00589.22 CDF34480.1 - 4.2e-17 62.5 0.0 1.1e-16 61.2 0.0 1.7 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CDF34480.1 - 0.013 15.8 0.2 0.12 12.7 0.0 2.7 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 CDF34480.1 - 0.021 15.3 0.1 0.13 12.8 0.0 2.4 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DDE_Tnp_IS240 PF13610.6 CDF34481.1 - 8.5e-29 100.6 0.2 1.2e-28 100.1 0.2 1.2 1 0 0 1 1 1 1 DDE domain DDE_Tnp_IS66 PF03050.14 CDF34481.1 - 3.9e-06 26.5 0.6 4.7e-06 26.3 0.6 1.2 1 0 0 1 1 1 1 Transposase IS66 family MULE PF10551.9 CDF34481.1 - 0.00051 20.4 0.0 0.0013 19.1 0.0 1.6 1 1 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 CDF34481.1 - 0.00061 18.8 0.0 0.00064 18.7 0.0 1.1 1 0 0 1 1 1 1 Transposase, Mutator family rve PF00665.26 CDF34481.1 - 0.00079 19.6 0.1 0.0016 18.6 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_ISL3 PF01610.17 CDF34481.1 - 0.0035 17.1 0.0 0.0062 16.3 0.0 1.3 1 0 0 1 1 1 1 Transposase SpvB PF03534.13 CDF34481.1 - 0.031 13.4 0.1 0.041 13.1 0.1 1.2 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein DDE_3 PF13358.6 CDF34481.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_23 PF13384.6 CDF34482.1 - 1.4e-08 34.2 0.1 2.1e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CDF34482.1 - 7e-08 32.4 0.3 1e-07 31.9 0.3 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 CDF34482.1 - 1.4e-07 31.2 1.3 2.1e-07 30.6 1.3 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 CDF34482.1 - 6.1e-06 26.3 0.2 9.2e-06 25.7 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 CDF34482.1 - 1.9e-05 24.6 0.1 3.1e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix Sigma70_r4_2 PF08281.12 CDF34482.1 - 3.5e-05 23.4 0.1 5.2e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 CDF34482.1 - 3.7e-05 23.0 0.7 8.2e-05 21.9 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 GerE PF00196.19 CDF34482.1 - 6.8e-05 22.3 0.0 8.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family TnsD PF15978.5 CDF34482.1 - 0.00013 21.0 0.0 0.00014 21.0 0.0 1.1 1 0 0 1 1 1 1 Tn7-like transposition protein D HTH_11 PF08279.12 CDF34482.1 - 0.00017 21.5 0.4 0.00036 20.4 0.3 1.7 2 0 0 2 2 1 1 HTH domain NUMOD1 PF07453.13 CDF34482.1 - 0.0002 21.5 0.0 0.00026 21.2 0.0 1.2 1 0 0 1 1 1 1 NUMOD1 domain Sigma70_r4 PF04545.16 CDF34482.1 - 0.00028 20.4 0.8 0.0004 19.8 0.8 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_3 PF01381.22 CDF34482.1 - 0.00033 20.6 0.0 0.00038 20.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_24 PF13412.6 CDF34482.1 - 0.00042 19.8 0.2 0.00065 19.2 0.2 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_40 PF14493.6 CDF34482.1 - 0.00065 20.1 0.0 0.0007 20.0 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_1 PF11427.8 CDF34482.1 - 0.0012 18.7 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Tc3 transposase HTH_8 PF02954.19 CDF34482.1 - 0.0019 17.9 0.2 0.0028 17.4 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HTH_17 PF12728.7 CDF34482.1 - 0.0025 18.0 0.3 0.0084 16.3 0.1 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_DeoR PF08220.12 CDF34482.1 - 0.0026 17.4 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_22 PF13309.6 CDF34482.1 - 0.0034 17.4 0.0 0.0051 16.9 0.0 1.4 1 1 0 1 1 1 1 HTH domain HTH_AsnC-type PF13404.6 CDF34482.1 - 0.0037 17.0 0.1 0.0057 16.5 0.1 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_30 PF13556.6 CDF34482.1 - 0.0047 16.7 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_IclR PF09339.10 CDF34482.1 - 0.0068 16.2 0.1 0.01 15.6 0.1 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_50 PF18024.1 CDF34482.1 - 0.0091 15.6 0.2 0.015 14.9 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MerR PF00376.23 CDF34482.1 - 0.0093 15.7 1.1 0.011 15.4 0.2 1.6 2 0 0 2 2 1 1 MerR family regulatory protein CENP-B_N PF04218.13 CDF34482.1 - 0.0095 15.6 0.1 0.014 15.1 0.1 1.2 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_36 PF13730.6 CDF34482.1 - 0.0098 15.8 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF3562 PF12085.8 CDF34482.1 - 0.0098 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3562) HTH_10 PF04967.12 CDF34482.1 - 0.013 15.2 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 HTH DNA binding domain HTH_Crp_2 PF13545.6 CDF34482.1 - 0.014 15.4 0.1 0.028 14.4 0.1 1.7 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_31 PF13560.6 CDF34482.1 - 0.014 15.8 0.2 0.016 15.6 0.2 1.3 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_5 PF01022.20 CDF34482.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_35 PF13693.6 CDF34482.1 - 0.019 15.0 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF3071 PF11268.8 CDF34482.1 - 0.02 15.0 0.3 0.025 14.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Crp PF00325.20 CDF34482.1 - 0.026 14.2 0.6 0.064 12.9 0.6 1.8 1 1 0 1 1 1 0 Bacterial regulatory proteins, crp family MarR_2 PF12802.7 CDF34482.1 - 0.026 14.4 0.1 0.042 13.7 0.1 1.3 1 0 0 1 1 1 0 MarR family Phage_NinH PF06322.11 CDF34482.1 - 0.039 13.8 0.1 0.053 13.4 0.1 1.2 1 0 0 1 1 1 0 Phage NinH protein GntR PF00392.21 CDF34482.1 - 0.04 13.6 0.2 0.075 12.7 0.2 1.5 1 1 0 1 1 1 0 Bacterial regulatory proteins, gntR family SpoIIID PF12116.8 CDF34482.1 - 0.041 14.0 0.0 0.045 13.8 0.0 1.2 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_Tnp_1 PF01527.20 CDF34482.1 - 0.051 13.9 0.0 0.074 13.4 0.0 1.2 1 0 0 1 1 1 0 Transposase TrmB PF01978.19 CDF34482.1 - 0.061 13.2 0.1 0.094 12.6 0.1 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Terminase_5 PF06056.12 CDF34482.1 - 0.069 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_26 PF13443.6 CDF34482.1 - 0.075 13.5 0.0 0.088 13.3 0.0 1.2 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_Tnp_Tc3_2 PF01498.18 CDF34482.1 - 0.09 13.0 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Transposase MerR_1 PF13411.6 CDF34482.1 - 0.096 12.8 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 MerR HTH family regulatory protein TetR_N PF00440.23 CDF34482.1 - 0.098 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family DUF2089 PF09862.9 CDF34482.1 - 0.12 12.5 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) DDE_Tnp_IS240 PF13610.6 CDF34483.1 - 5.7e-38 130.3 0.0 7.4e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 DDE domain Apelin PF15360.6 CDF34483.1 - 7.5 7.2 10.2 46 4.7 0.1 3.4 3 0 0 3 3 3 0 APJ endogenous ligand DDE_Tnp_IS240 PF13610.6 CDF34484.1 - 7.9e-33 113.6 0.1 1.1e-32 113.2 0.1 1.1 1 0 0 1 1 1 1 DDE domain DDE_3 PF13358.6 CDF34484.1 - 0.038 13.8 0.1 0.053 13.3 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease DPRP PF04244.13 CDF34484.1 - 0.078 12.8 1.1 0.1 12.4 1.1 1.1 1 0 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein ApbA PF02558.16 CDF34485.1 - 1.7e-32 112.2 0.0 2.5e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CDF34485.1 - 4.7e-23 81.8 0.0 1.9e-22 79.8 0.0 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal F420_oxidored PF03807.17 CDF34485.1 - 0.00059 20.4 0.3 0.0026 18.3 0.1 2.2 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AAA_22 PF13401.6 CDF34486.1 - 1.1e-09 38.7 0.0 2.1e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CDF34486.1 - 2.2e-06 27.2 0.0 3.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 CDF34486.1 - 7e-06 26.5 0.0 0.00018 21.9 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDF34487.1 - 5.7e-11 42.9 0.0 2.3e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CDF34487.1 - 2.4e-06 27.1 0.0 3.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 CDF34487.1 - 4e-06 27.3 0.0 0.00015 22.2 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain Exo_endo_phos PF03372.23 CDF34488.1 - 0.0016 18.0 0.0 0.0089 15.6 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RNA_pol_Rpb2_6 PF00562.28 CDF34489.1 - 1e-25 90.6 0.0 1.5e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb1_2 PF00623.20 CDF34489.1 - 3.9e-18 66.2 0.0 5.3e-17 62.5 0.0 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 CDF34489.1 - 1.9e-12 47.2 0.0 4.3e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb2_7 PF04560.20 CDF34489.1 - 0.002 18.5 0.0 0.005 17.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 PAS_4 PF08448.10 CDF34489.1 - 0.029 14.6 0.5 0.029 14.6 0.5 2.7 4 0 0 4 4 4 0 PAS fold RNA_pol_Rpb1_4 PF05000.17 CDF34489.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 Mito_carr PF00153.27 CDF34490.1 - 1.8e-21 75.8 0.1 3.8e-21 74.8 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial carrier protein Mito_carr PF00153.27 CDF34491.1 - 6.6e-18 64.4 0.2 1.3e-16 60.3 0.1 2.0 2 0 0 2 2 2 1 Mitochondrial carrier protein Med10 PF09748.9 CDF34491.1 - 0.13 12.3 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex Peptidase_C26 PF07722.13 CDF34492.1 - 2.1e-40 138.8 0.0 1e-39 136.5 0.0 2.0 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDF34492.1 - 3e-11 43.5 0.0 5.4e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Plant_tran PF04827.14 CDF34493.1 - 7.8e-50 169.3 0.1 7e-45 153.2 0.0 2.4 1 1 1 2 2 2 2 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF34493.1 - 8.6e-10 38.5 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1_2 PF13586.6 CDF34493.1 - 0.06 13.7 0.1 0.093 13.1 0.1 1.3 1 0 0 1 1 1 0 Transposase DDE domain ANTH PF07651.16 CDF34493.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 ANTH domain ANTAR PF03861.14 CDF34493.1 - 0.14 12.0 0.4 0.43 10.4 0.2 1.9 2 0 0 2 2 2 0 ANTAR domain DUF547 PF04784.14 CDF34495.1 - 3.8e-35 120.6 0.0 5.8e-35 120.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DNA_pol_E_B PF04042.16 CDF34496.1 - 8.3e-40 136.4 0.0 1.2e-39 135.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Nramp PF01566.18 CDF34498.1 - 6.5e-132 439.8 14.3 9.1e-132 439.4 14.3 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein FSH1 PF03959.13 CDF34501.1 - 8e-44 149.8 0.0 1.1e-43 149.4 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CDF34501.1 - 0.0002 21.2 0.0 0.00039 20.3 0.0 1.5 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase RES PF08808.11 CDF34501.1 - 0.0036 17.2 0.0 0.0066 16.3 0.0 1.4 1 0 0 1 1 1 1 RES domain TFIID-18kDa PF02269.16 CDF34502.1 - 0.002 18.1 0.0 0.0034 17.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit SOG2 PF10428.9 CDF34502.1 - 3.2 6.8 8.1 4.9 6.2 8.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein MCM PF00493.23 CDF34504.1 - 2.3e-102 340.9 0.1 3.3e-102 340.3 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDF34504.1 - 2.7e-39 133.9 0.2 4.6e-39 133.1 0.2 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDF34504.1 - 9.7e-26 90.0 0.5 2.2e-25 88.9 0.5 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 CDF34504.1 - 1.1e-15 57.8 0.1 1.1e-15 57.8 0.1 1.9 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 CDF34504.1 - 1.5e-08 34.3 0.0 3.7e-07 29.7 0.0 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 CDF34504.1 - 8e-05 23.2 0.0 0.00027 21.5 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain AAA_3 PF07726.11 CDF34504.1 - 0.00098 19.0 0.0 0.0022 17.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDF34504.1 - 0.0012 18.5 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 CDF34504.1 - 0.0017 18.4 0.0 0.0037 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NB PF04159.13 CDF34505.1 - 0.04 13.9 1.1 0.043 13.8 1.1 1.2 1 0 0 1 1 1 0 NB glycoprotein P21-Arc PF04062.14 CDF34505.1 - 0.13 12.3 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 ARP2/3 complex ARPC3 (21 kDa) subunit DUF1514 PF07438.11 CDF34505.1 - 0.17 11.8 2.5 0.27 11.1 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) Glycophorin_A PF01102.18 CDF34505.1 - 0.36 11.1 0.8 0.5 10.6 0.8 1.2 1 0 0 1 1 1 0 Glycophorin A XPG_N PF00752.17 CDF34506.1 - 1.2e-26 93.2 0.0 3.5e-26 91.6 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CDF34506.1 - 3.6e-25 88.1 0.0 1.1e-24 86.6 0.0 1.9 1 0 0 1 1 1 1 XPG I-region PHF5 PF03660.14 CDF34508.1 - 3.7e-17 62.4 4.9 4e-17 62.3 4.9 1.2 1 0 0 1 1 1 1 PHF5-like protein eRF1_2 PF03464.15 CDF34510.1 - 1.1e-45 155.2 0.0 1.7e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CDF34510.1 - 1e-32 113.0 0.4 1.9e-32 112.1 0.4 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 CDF34510.1 - 1.1e-18 67.4 0.0 2.7e-18 66.2 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 CDF34510.1 - 2.2e-08 34.5 0.0 3.5e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 CDF34510.1 - 5.7e-08 33.1 0.1 1.3e-07 31.9 0.0 1.6 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 DUF5341 PF17276.2 CDF34510.1 - 0.11 12.7 0.7 7 6.8 0.3 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5341) VanY PF02557.17 CDF34510.1 - 0.15 11.9 0.5 2.5 7.9 0.2 2.7 3 0 0 3 3 3 0 D-alanyl-D-alanine carboxypeptidase Peptidase_M20 PF01546.28 CDF34511.1 - 3.2e-32 111.9 0.0 4.3e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDF34511.1 - 1.8e-16 60.0 0.0 3.1e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Ferrochelatase PF00762.19 CDF34512.1 - 1.6e-87 293.6 0.0 1.8e-87 293.4 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 CDF34512.1 - 7.9e-05 22.9 0.0 0.002 18.4 0.0 2.3 2 0 0 2 2 2 1 CbiX Sugar-bind PF04198.13 CDF34512.1 - 0.037 13.2 0.0 0.061 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative sugar-binding domain Sec1 PF00995.23 CDF34513.1 - 3.5e-83 280.8 0.0 4.1e-83 280.5 0.0 1.1 1 0 0 1 1 1 1 Sec1 family BSD PF03909.17 CDF34513.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 BSD domain ABC2_membrane PF01061.24 CDF34514.1 - 3.9e-78 261.7 49.7 4.2e-41 140.7 25.7 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 CDF34514.1 - 2.6e-26 92.8 0.0 3.3e-14 53.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CDF34514.1 - 6.1e-13 48.6 41.4 2.8e-09 36.6 11.8 2.9 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 CDF34514.1 - 4.4e-06 27.2 0.2 0.025 15.0 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDF34514.1 - 9e-06 25.7 1.6 0.0034 17.3 0.2 3.3 3 0 0 3 3 3 1 RsgA GTPase AAA_25 PF13481.6 CDF34514.1 - 3.8e-05 23.3 0.8 0.0087 15.7 0.4 2.5 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CDF34514.1 - 7.2e-05 22.4 1.2 0.00082 19.1 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CDF34514.1 - 0.0073 16.2 0.4 1.1 9.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CDF34514.1 - 0.016 15.1 0.0 4.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_22 PF13401.6 CDF34514.1 - 0.027 14.7 3.8 2.8 8.2 0.7 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDF34514.1 - 0.054 13.9 0.0 5.7 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF2399 PF09664.10 CDF34514.1 - 0.064 13.2 0.2 0.16 11.9 0.0 1.7 2 0 0 2 2 1 0 Protein of unknown function C-terminus (DUF2399) AAA_23 PF13476.6 CDF34514.1 - 0.25 11.8 0.2 0.48 10.9 0.2 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDF34514.1 - 0.26 11.2 1.9 4.5 7.2 0.3 2.6 3 0 0 3 3 2 0 NACHT domain GMC_oxred_N PF00732.19 CDF34515.1 - 0.00054 19.4 0.0 0.00076 18.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase ABC2_membrane PF01061.24 CDF34516.1 - 1.5e-07 31.1 0.1 2.1e-07 30.6 0.1 1.1 1 0 0 1 1 1 1 ABC-2 type transporter DUF568 PF04526.13 CDF34516.1 - 0.12 13.1 0.0 0.19 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF568) DUF1163 PF06651.11 CDF34520.1 - 0.026 14.6 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1163) Sigma_reg_N PF13800.6 CDF34522.1 - 0.14 12.5 1.2 0.98 9.7 1.0 2.6 3 0 0 3 3 3 0 Sigma factor regulator N-terminal tRNA-synt_1e PF01406.19 CDF34527.1 - 1.6e-121 405.3 0.0 2.9e-121 404.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDF34527.1 - 2.6e-09 36.3 0.5 0.0014 17.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1c PF00749.21 CDF34527.1 - 0.00055 18.9 0.0 0.0015 17.5 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1 PF00133.22 CDF34527.1 - 0.0053 15.1 0.1 0.017 13.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 CDF34527.1 - 0.025 15.0 0.0 0.089 13.3 0.0 2.0 1 0 0 1 1 1 0 DALR domain Aminotran_3 PF00202.21 CDF34528.1 - 9.8e-118 393.3 0.0 1.2e-117 393.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Kelch_6 PF13964.6 CDF34529.1 - 1.2e-29 101.6 9.3 9.1e-06 25.8 0.1 7.0 4 3 3 7 7 7 6 Kelch motif Hint PF01079.20 CDF34529.1 - 1.6e-24 86.7 0.1 2.6e-24 85.9 0.1 1.2 1 0 0 1 1 1 1 Hint module Kelch_1 PF01344.25 CDF34529.1 - 2.1e-15 56.0 4.9 6.8e-05 22.4 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 CDF34529.1 - 1.9e-13 50.2 15.6 0.0029 17.6 0.3 6.0 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CDF34529.1 - 2.2e-12 46.6 0.5 0.00031 20.7 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 CDF34529.1 - 1.9e-09 37.1 3.4 0.035 14.1 0.0 5.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 CDF34529.1 - 8.9e-07 29.1 6.3 0.016 15.5 0.2 5.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Vint PF14623.6 CDF34529.1 - 0.035 13.9 0.0 0.091 12.6 0.0 1.6 1 1 0 1 1 1 0 Hint-domain PRCC PF10253.9 CDF34529.1 - 1 10.1 4.3 1.6 9.4 4.3 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting SPX PF03105.19 CDF34529.1 - 2 8.3 3.5 2.8 7.8 3.5 1.2 1 0 0 1 1 1 0 SPX domain Spond_N PF06468.13 CDF34530.1 - 9.9e-23 81.3 0.0 1.2e-22 81.0 0.0 1.1 1 0 0 1 1 1 1 Spondin_N TPPK_C PF12555.8 CDF34530.1 - 0.34 11.0 4.3 0.29 11.2 1.8 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal YbgT_YccB PF08173.11 CDF34530.1 - 3.3 7.9 5.3 9.8 6.4 5.3 1.8 1 0 0 1 1 1 0 Membrane bound YbgT-like protein Retrotran_gag_2 PF14223.6 CDF34531.1 - 3.1e-33 114.4 0.0 5.2e-33 113.6 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF34531.1 - 6.4e-21 74.8 0.0 1.5e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF34531.1 - 0.0015 18.3 0.0 0.0034 17.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF4219 PF13961.6 CDF34531.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) zf-CCHC PF00098.23 CDF34531.1 - 0.28 11.4 4.0 0.5 10.5 4.0 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF34531.1 - 0.41 10.4 4.2 1.2 8.9 4.2 1.8 1 0 0 1 1 1 0 Zinc knuckle Amino_oxidase PF01593.24 CDF34533.1 - 3.6e-86 290.2 0.1 5.7e-63 213.8 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF34533.1 - 1.6e-12 47.4 0.1 3.8e-12 46.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF34533.1 - 3.2e-05 23.7 0.1 0.00012 21.8 0.0 2.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF34533.1 - 8.3e-05 22.0 0.1 0.00016 21.0 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CDF34533.1 - 0.00028 20.3 0.2 0.00059 19.2 0.2 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CDF34533.1 - 0.00076 18.8 0.1 0.0012 18.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CDF34533.1 - 0.0012 18.1 0.1 0.0022 17.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CDF34533.1 - 0.0015 17.3 0.3 0.0023 16.7 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein SWIRM PF04433.17 CDF34533.1 - 0.0042 17.4 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain NAD_binding_9 PF13454.6 CDF34533.1 - 0.0084 16.1 0.1 0.03 14.3 0.0 2.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 CDF34533.1 - 0.012 14.9 0.5 0.022 14.1 0.5 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CDF34533.1 - 0.014 15.9 0.1 0.043 14.4 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF34533.1 - 0.017 14.2 0.3 0.025 13.7 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain IlvN PF07991.12 CDF34533.1 - 0.14 11.7 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Flavoprotein PF02441.19 CDF34534.1 - 7.5e-50 168.8 0.0 9e-50 168.5 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein NAD_binding_7 PF13241.6 CDF34534.1 - 0.0088 16.5 0.1 0.017 15.6 0.0 1.5 1 1 0 1 1 1 1 Putative NAD(P)-binding TPR_12 PF13424.6 CDF34535.1 - 2.7e-08 34.0 9.3 0.019 15.3 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDF34535.1 - 0.0035 17.3 7.9 3.2 8.1 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDF34535.1 - 0.015 15.2 14.4 0.68 9.9 2.8 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF34535.1 - 0.055 14.1 5.9 0.95 10.2 0.7 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF34535.1 - 0.086 13.4 7.5 5.4 7.6 0.5 4.5 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDF34535.1 - 1.9 9.4 8.0 0.46 11.2 1.8 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF34535.1 - 3.7 7.8 7.8 18 5.6 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF34535.1 - 3.8 7.5 4.5 71 3.5 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_9 PF14580.6 CDF34536.1 - 3.7e-26 91.7 0.3 4.1e-26 91.5 0.3 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 CDF34536.1 - 5e-12 45.4 0.7 7.9e-07 28.7 0.1 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDF34536.1 - 1.7e-08 34.6 0.9 3.3e-05 24.1 0.0 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDF34536.1 - 0.0031 17.4 0.6 3.8 7.8 0.1 3.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 CDF34536.1 - 0.033 14.7 0.1 38 5.4 0.0 3.6 4 1 0 4 4 4 0 Leucine Rich Repeat VirC2 PF07181.11 CDF34537.1 - 0.15 11.5 0.3 0.21 11.0 0.3 1.2 1 0 0 1 1 1 0 VirC2 protein KH_1 PF00013.29 CDF34538.1 - 2.1e-49 165.2 1.2 2.1e-17 62.7 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CDF34538.1 - 4.1e-12 45.8 0.2 0.012 15.4 0.0 3.7 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CDF34538.1 - 3.5e-11 42.8 0.4 0.01 15.6 0.1 3.3 3 0 0 3 3 3 3 KH domain SLS PF14611.6 CDF34538.1 - 0.018 14.9 0.0 24 4.7 0.0 3.2 1 1 3 4 4 4 0 Mitochondrial inner-membrane-bound regulator Med18 PF09637.10 CDF34539.1 - 0.074 12.9 0.0 0.087 12.6 0.0 1.1 1 0 0 1 1 1 0 Med18 protein NUDIX PF00293.28 CDF34540.1 - 8.4e-15 55.0 0.0 1.8e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain Acetyltransf_1 PF00583.25 CDF34540.1 - 7.5e-12 45.5 0.1 1.4e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF34540.1 - 2.1e-07 31.3 0.1 5.5e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDF34540.1 - 2.4e-05 24.3 0.0 4.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF34540.1 - 0.0025 17.7 0.0 0.0048 16.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CDF34540.1 - 0.041 14.0 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase PBS_linker_poly PF00427.21 CDF34541.1 - 7.1e-40 135.9 0.1 1.7e-39 134.7 0.1 1.6 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide PSD1 PF07587.11 CDF34541.1 - 0.029 13.9 0.1 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1553) HR1 PF02185.16 CDF34541.1 - 0.58 10.3 3.5 2.2 8.5 2.5 2.4 3 0 0 3 3 3 0 Hr1 repeat DUF572 PF04502.13 CDF34542.1 - 4.9e-65 220.3 6.1 7e-65 219.8 6.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) TF_Zn_Ribbon PF08271.12 CDF34542.1 - 0.0014 18.1 0.5 0.0014 18.1 0.5 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding zf-ZPR1 PF03367.13 CDF34542.1 - 0.43 10.4 5.0 3.1 7.6 0.0 3.3 3 1 0 3 3 3 0 ZPR1 zinc-finger domain DUF4051 PF13260.6 CDF34542.1 - 0.49 10.2 1.6 1.2 8.9 0.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4051) Tubulin PF00091.25 CDF34543.1 - 1.1e-68 231.3 0.0 6e-68 228.9 0.0 1.9 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDF34543.1 - 1e-38 132.3 0.0 1.7e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDF34543.1 - 0.00076 19.2 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CDF34543.1 - 0.0026 17.0 0.0 0.01 15.1 0.0 1.8 2 0 0 2 2 2 1 Tubulin like Misat_Tub_SegII PF10644.9 CDF34543.1 - 0.0048 17.2 0.0 0.014 15.7 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain EC042_2821 PF18740.1 CDF34543.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 EC042_2821-lke REase GRP PF07172.11 CDF34546.1 - 1.5 9.5 35.8 2 9.2 35.8 1.3 1 0 0 1 1 1 0 Glycine rich protein family Ribonuclease_3 PF00636.26 CDF34548.1 - 2.6e-34 118.0 0.0 1.2e-16 61.2 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CDF34548.1 - 3.2e-31 108.1 0.0 2e-14 53.9 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease-III-like Helicase_C PF00271.31 CDF34548.1 - 3.7e-14 53.0 0.0 1.4e-13 51.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Dicer_dimer PF03368.14 CDF34548.1 - 2.3e-12 46.9 0.1 1.1e-11 44.7 0.0 2.3 2 0 0 2 2 2 1 Dicer dimerisation domain DEAD PF00270.29 CDF34548.1 - 2.7e-10 40.3 0.0 5.3e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF34548.1 - 5.2e-10 39.6 0.0 1.2e-05 25.4 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PAZ PF02170.22 CDF34548.1 - 4e-09 36.4 0.0 9.7e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 PAZ domain dsrm PF00035.26 CDF34548.1 - 0.00034 21.3 0.0 0.0061 17.2 0.0 2.7 2 0 0 2 2 2 1 Double-stranded RNA binding motif G-patch PF01585.23 CDF34550.1 - 1.3e-07 31.3 0.7 2.8e-07 30.3 0.7 1.6 1 0 0 1 1 1 1 G-patch domain FXR_C3 PF16097.5 CDF34550.1 - 6.7 7.5 6.4 0.8 10.4 1.2 2.2 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 3 APH PF01636.23 CDF34553.1 - 1.3e-15 58.0 0.2 1.7e-08 34.7 0.1 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family DUF1679 PF07914.11 CDF34553.1 - 5.7e-05 22.1 0.2 0.22 10.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 CDF34553.1 - 0.00085 19.0 0.5 0.0034 17.0 0.3 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase EcKinase PF02958.20 CDF34553.1 - 0.0017 17.8 2.5 0.0059 16.0 0.1 2.4 3 0 0 3 3 3 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 CDF34553.1 - 0.013 14.7 0.0 0.27 10.4 0.0 2.3 2 0 0 2 2 2 0 Fructosamine kinase RIO1 PF01163.22 CDF34553.1 - 0.14 11.7 0.1 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 RIO1 family Sel1 PF08238.12 CDF34554.1 - 7.8e-38 128.1 7.4 3.1e-06 27.7 0.0 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.6 CDF34554.1 - 5.8e-08 32.9 9.7 0.12 13.1 0.1 6.9 7 2 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF34554.1 - 4.5e-07 29.8 0.2 32 5.2 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat PPR_long PF17177.4 CDF34554.1 - 0.00016 21.1 0.3 7.4 5.9 0.0 3.9 3 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP TPR_7 PF13176.6 CDF34554.1 - 0.00067 19.5 5.8 0.097 12.7 0.1 5.7 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF34554.1 - 2.3 8.8 4.6 10 6.7 0.1 3.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF34554.1 - 2.7 8.3 14.1 4.1 7.8 0.0 6.4 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF34554.1 - 5 8.2 8.9 1.7 9.6 0.2 4.3 5 1 1 6 6 6 0 Tetratricopeptide repeat DAP3 PF10236.9 CDF34556.1 - 1.2e-17 64.0 0.0 2.7e-17 62.9 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CDF34556.1 - 8.6e-07 29.5 0.0 3.7e-06 27.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA-ATPase_like PF09820.9 CDF34556.1 - 0.00065 19.2 0.0 0.00096 18.6 0.0 1.3 1 0 0 1 1 1 1 Predicted AAA-ATPase AAA_22 PF13401.6 CDF34556.1 - 0.00073 19.8 0.1 0.2 12.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF34556.1 - 0.078 12.9 0.4 2.9 7.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_35 PF14516.6 CDF34556.1 - 0.12 11.2 0.0 2 7.2 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain Zeta_toxin PF06414.12 CDF34556.1 - 0.13 11.5 0.0 0.42 9.9 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_5 PF07728.14 CDF34556.1 - 0.16 11.9 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CDF34556.1 - 0.18 12.2 0.0 1.7 9.0 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CDF34556.1 - 0.19 11.6 0.0 0.77 9.6 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Sel1 PF08238.12 CDF34558.1 - 7.3e-33 112.3 4.4 9.6e-07 29.3 0.1 6.5 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.6 CDF34558.1 - 6.5e-08 32.7 3.6 0.061 14.0 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF34558.1 - 9.4e-05 22.5 0.2 35 5.1 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF34558.1 - 0.084 12.9 6.7 0.24 11.5 0.1 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF34558.1 - 0.095 13.2 0.7 24 5.5 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_long PF17177.4 CDF34558.1 - 0.13 11.6 0.3 12 5.1 0.0 2.8 3 1 1 4 4 4 0 Pentacotripeptide-repeat region of PRORP DUF3151 PF11349.8 CDF34558.1 - 0.14 12.3 0.1 0.31 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3151) TPR_14 PF13428.6 CDF34558.1 - 6.4 7.9 6.6 4 8.5 0.2 4.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Plant_tran PF04827.14 CDF34559.1 - 1.6e-32 112.8 0.0 1.1e-29 103.5 0.0 2.3 1 1 1 2 2 2 2 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF34559.1 - 2.5e-06 27.3 0.0 3.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Myb_DNA-binding PF00249.31 CDF34560.1 - 5.5e-05 23.3 0.0 9.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4131 PF13567.6 CDF34562.1 - 1.5 8.5 5.1 0.72 9.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SPC25 PF06703.11 CDF34564.1 - 8.4e-24 84.2 0.0 9.8e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Glyco_trans_A_1 PF09318.10 CDF34564.1 - 0.0069 16.1 0.0 0.16 11.6 0.0 2.4 2 1 1 3 3 3 1 Glycosyl transferase 1 domain A Amino_oxidase PF01593.24 CDF34565.1 - 4.2e-13 49.4 0.8 3.5e-12 46.4 0.8 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 CDF34565.1 - 9.1e-10 38.6 0.0 3.9e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF34565.1 - 1.9e-07 30.7 3.4 0.00071 18.9 0.3 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF34565.1 - 9.8e-07 28.2 1.1 0.0091 15.1 0.4 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 CDF34565.1 - 5.4e-06 25.9 0.6 0.021 14.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CDF34565.1 - 6.3e-06 26.3 0.7 2.5e-05 24.4 0.1 2.4 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDF34565.1 - 5.5e-05 23.6 0.7 0.38 11.3 0.0 3.7 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDF34565.1 - 0.00029 20.0 0.1 0.00059 19.0 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 CDF34565.1 - 0.00059 18.6 0.6 0.054 12.2 0.3 2.2 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_9 PF13454.6 CDF34565.1 - 0.00073 19.5 1.3 0.029 14.3 0.1 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CDF34565.1 - 0.00081 18.7 0.1 0.0017 17.6 0.1 1.5 1 0 0 1 1 1 1 Thi4 family ApbA PF02558.16 CDF34565.1 - 0.071 12.8 0.2 2.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 CDF34565.1 - 0.097 11.9 0.4 0.19 10.9 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF34565.1 - 0.14 11.2 0.7 0.24 10.5 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 CDF34565.1 - 0.18 11.7 0.2 0.38 10.6 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SMC_N PF02463.19 CDF34566.1 - 1.4e-67 227.3 0.0 2.2e-67 226.7 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDF34566.1 - 3.6e-22 78.9 0.2 1.2e-21 77.2 0.2 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 CDF34566.1 - 8.5e-15 55.8 0.3 8.5e-15 55.8 0.3 5.8 3 2 1 4 4 3 1 AAA domain AAA_21 PF13304.6 CDF34566.1 - 1.1e-11 45.1 0.1 0.00016 21.6 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDF34566.1 - 1.3e-09 38.2 0.0 1.3e-09 38.2 0.0 3.5 2 2 0 2 2 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF34566.1 - 0.0005 19.8 0.0 0.0015 18.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain YscO PF07321.12 CDF34566.1 - 0.011 15.7 4.8 0.011 15.7 4.8 6.9 3 2 2 6 6 5 0 Type III secretion protein YscO ABC_tran PF00005.27 CDF34566.1 - 0.039 14.5 17.4 0.27 11.8 3.4 5.1 3 2 1 4 4 4 0 ABC transporter Tox-REase-5 PF15648.6 CDF34566.1 - 0.41 11.2 4.6 0.2 12.2 0.5 2.7 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 5 RNase_H2-Ydr279 PF09468.10 CDF34566.1 - 1.3 9.2 15.9 1.3 9.1 0.0 3.5 2 2 1 3 3 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain TLE_N PF03920.15 CDF34566.1 - 2.5 8.2 9.0 5.1 7.2 0.0 3.7 3 1 0 3 3 3 0 Groucho/TLE N-terminal Q-rich domain NPV_P10 PF05531.12 CDF34566.1 - 8.7 6.9 23.9 25 5.4 0.1 7.5 7 2 1 8 8 8 0 Nucleopolyhedrovirus P10 protein eIF3g PF12353.8 CDF34567.1 - 1.7e-20 73.7 2.8 2.8e-20 73.0 2.8 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 CDF34567.1 - 1.2e-17 63.5 0.0 2.1e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF34567.1 - 0.0037 17.1 0.0 0.0083 16.0 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif DUF3994 PF13159.6 CDF34567.1 - 0.072 13.6 0.1 3.9 8.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3994) Cmc1 PF08583.10 CDF34568.1 - 0.00035 20.5 17.1 0.0047 16.9 5.4 2.4 1 1 2 3 3 3 2 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 CDF34568.1 - 0.0053 17.1 3.5 0.0053 17.1 3.5 1.8 1 1 0 1 1 1 1 GCK domain CHCH PF06747.13 CDF34568.1 - 0.012 15.8 5.9 0.012 15.8 5.9 2.4 2 1 0 2 2 2 0 CHCH domain Pet191_N PF10203.9 CDF34568.1 - 0.015 15.6 9.9 1.1 9.6 0.6 3.1 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 CDF34568.1 - 0.06 13.4 9.7 0.14 12.2 3.3 2.4 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3716 PF12511.8 CDF34568.1 - 0.15 12.1 7.8 0.64 10.1 0.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3716) UPF0203 PF05254.12 CDF34568.1 - 0.77 10.0 6.3 1 9.6 4.9 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 CDF34568.1 - 2.3 8.5 8.6 0.52 10.6 1.9 2.3 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Peptidase_S41 PF03572.18 CDF34569.1 - 2.8e-41 140.8 0.0 4.5e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S41 PDZ_2 PF13180.6 CDF34569.1 - 6e-10 39.3 0.1 2.6e-09 37.3 0.0 2.0 3 0 0 3 3 3 1 PDZ domain PDZ_6 PF17820.1 CDF34569.1 - 3e-09 36.6 0.0 6.4e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDF34569.1 - 5.7e-08 33.0 0.1 1.1e-07 32.1 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Peripla_BP_1 PF00532.21 CDF34569.1 - 0.11 11.9 0.1 0.96 8.8 0.0 2.2 2 0 0 2 2 2 0 Periplasmic binding proteins and sugar binding domain of LacI family RRM_1 PF00076.22 CDF34572.1 - 2.8e-13 49.5 0.0 4.3e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 CDF34573.1 - 1.2e-10 41.0 0.2 2.7e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4407 PF14362.6 CDF34573.1 - 7.9 5.7 10.1 11 5.3 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF179 PF02622.15 CDF34574.1 - 1.6e-05 25.0 0.0 4.5e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 zf-RanBP PF00641.18 CDF34577.1 - 0.00046 19.4 4.3 0.00076 18.7 4.3 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DZR PF12773.7 CDF34577.1 - 0.0046 17.0 1.1 0.0093 16.0 1.1 1.5 1 0 0 1 1 1 1 Double zinc ribbon zf-CCHC PF00098.23 CDF34577.1 - 0.019 15.0 0.8 0.019 15.0 0.8 2.3 1 1 1 2 2 2 0 Zinc knuckle DUF3811 PF11656.8 CDF34577.1 - 0.051 14.0 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 YjbD family (DUF3811) zinc_ribbon_2 PF13240.6 CDF34577.1 - 0.056 13.2 5.1 0.093 12.5 5.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_4 PF14392.6 CDF34577.1 - 0.092 12.5 2.6 0.17 11.7 2.6 1.4 1 0 0 1 1 1 0 Zinc knuckle Ribosomal_L37e PF01907.19 CDF34577.1 - 1.1 9.5 8.0 1.8 8.8 8.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L37e zf-ribbon_3 PF13248.6 CDF34577.1 - 1.7 8.1 5.8 5.6 6.5 5.8 1.9 1 1 0 1 1 1 0 zinc-ribbon domain DUF2499 PF10693.9 CDF34579.1 - 1.3e-38 131.1 4.4 4.8e-38 129.3 4.4 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2499) DUF3593 PF12159.8 CDF34579.1 - 2.8e-36 123.4 0.8 6.5e-36 122.3 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3593) DUF3819 PF12842.7 CDF34580.1 - 0.17 11.8 0.1 0.31 11.0 0.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3819) Cation_ATPase PF13246.6 CDF34581.1 - 4.9e-11 42.6 0.0 9.7e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDF34581.1 - 0.00068 19.2 0.3 0.00068 19.2 0.3 1.9 1 1 1 2 2 2 1 E1-E2 ATPase Acetyltransf_13 PF13880.6 CDF34582.1 - 0.083 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase bHLH-MYC_N PF14215.6 CDF34582.1 - 0.11 12.8 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal PAF PF15715.5 CDF34582.1 - 0.25 12.0 1.6 0.33 11.5 1.6 1.4 1 0 0 1 1 1 0 PCNA-associated factor histone like domain An_peroxidase PF03098.15 CDF34583.1 - 4.8e-110 368.6 0.0 5.5e-110 368.4 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 CDF34584.1 - 1.9e-110 370.0 0.0 2.2e-110 369.8 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 CDF34585.1 - 1.9e-110 370.0 0.0 2.2e-110 369.8 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase PDZ_3 PF17815.1 CDF34586.1 - 5.1e-37 126.9 0.1 7.8e-37 126.4 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 CDF34586.1 - 2.7e-22 80.3 0.1 5.9e-22 79.2 0.1 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDF34586.1 - 3.1e-12 46.8 0.0 1e-11 45.1 0.0 1.8 2 0 0 2 2 2 1 Trypsin PDZ_2 PF13180.6 CDF34586.1 - 1.4e-09 38.2 0.0 1.1e-06 28.8 0.0 2.6 2 0 0 2 2 2 2 PDZ domain Peptidase_S46 PF10459.9 CDF34586.1 - 0.015 14.0 0.1 0.022 13.4 0.1 1.2 1 0 0 1 1 1 0 Peptidase S46 PDZ PF00595.24 CDF34586.1 - 0.17 12.3 0.0 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 PDZ domain TIMP PF00965.17 CDF34589.1 - 1.1e-10 41.6 0.0 1.4e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase TIMP PF00965.17 CDF34590.1 - 4.4e-09 36.4 0.0 5.7e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase DUF5451 PF17532.2 CDF34593.1 - 0.0053 17.0 2.6 0.0064 16.8 2.6 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5451) Herpes_pp85 PF04637.12 CDF34593.1 - 0.37 9.2 2.2 0.42 9.0 2.2 1.0 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PIF1 PF05970.14 CDF34594.1 - 3.2e-81 273.3 0.0 2.1e-62 211.4 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CDF34594.1 - 3.6e-09 36.6 0.0 1.2e-06 28.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF34594.1 - 0.027 12.4 0.0 0.038 11.9 0.0 1.1 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF34594.1 - 0.059 13.2 0.1 0.2 11.5 0.1 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain NB-ARC PF00931.22 CDF34595.1 - 4.9e-14 52.1 0.0 9.5e-14 51.2 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.12 CDF34595.1 - 0.011 15.6 0.0 0.038 13.9 0.0 1.9 1 0 0 1 1 1 0 NACHT domain APAF1_C PF17908.1 CDF34595.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 APAF-1 helical domain UDPGT PF00201.18 CDF34598.1 - 0.0003 19.7 0.0 0.00066 18.6 0.0 1.5 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 CDF34598.1 - 0.0014 18.7 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 CDF34598.1 - 0.14 12.1 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain LRAT PF04970.13 CDF34602.1 - 2.1e-18 66.9 0.0 4.1e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Lecithin retinol acyltransferase SH3_12 PF18129.1 CDF34602.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Xrn1 SH3-like domain Peptidase_C97 PF05903.14 CDF34602.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 PPPDE putative peptidase domain SLT PF01464.20 CDF34604.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain YjeF_N PF03853.15 CDF34605.1 - 1.1e-23 84.0 0.0 1.8e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus ERCC3_RAD25_C PF16203.5 CDF34606.1 - 6e-116 385.9 0.1 1e-115 385.2 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 CDF34606.1 - 2.8e-32 111.5 0.0 5.6e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34606.1 - 1e-13 51.7 0.0 2.1e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDF34606.1 - 6.1e-10 39.4 0.0 1.3e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CDF34606.1 - 0.00042 19.2 0.0 0.00049 18.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain PGK PF00162.19 CDF34607.1 - 4.6e-150 499.8 3.3 5.2e-150 499.6 3.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PMSR PF01625.21 CDF34608.1 - 8.3e-66 220.9 0.4 9.6e-66 220.7 0.4 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Actin PF00022.19 CDF34608.1 - 0.16 10.6 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 Actin NAD_binding_1 PF00175.21 CDF34609.1 - 2.1e-12 47.6 0.0 4.7e-12 46.5 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CDF34609.1 - 0.22 11.6 0.0 13 5.9 0.0 2.3 2 0 0 2 2 2 0 Ferric reductase NAD binding domain DnaJ PF00226.31 CDF34610.1 - 3.2e-22 78.4 0.1 8.3e-22 77.1 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 CDF34610.1 - 1.2e-05 25.4 2.1 0.00015 22.0 0.3 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CDF34610.1 - 1.3e-05 25.4 1.9 0.13 12.6 0.2 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 CDF34610.1 - 0.0021 18.4 0.5 0.0021 18.4 0.5 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CDF34610.1 - 0.0063 17.2 2.9 0.068 14.0 0.2 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger Pkinase PF00069.25 CDF34612.1 - 9.7e-54 182.5 0.0 1.1e-53 182.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34612.1 - 2.4e-36 125.4 0.0 3.2e-36 124.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF34612.1 - 0.00031 19.7 0.0 0.00042 19.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF34612.1 - 0.0019 18.2 0.1 0.038 13.9 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF34612.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CDF34612.1 - 0.033 13.5 0.2 0.047 13.0 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF34612.1 - 0.15 11.3 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Rotavirus_VP7 PF05868.11 CDF34614.1 - 0.083 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Rotavirus major outer capsid protein VP7 AphA_like PF14557.6 CDF34614.1 - 0.091 12.5 0.1 0.14 11.9 0.1 1.2 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator Abhydrolase_6 PF12697.7 CDF34615.1 - 3.2e-16 60.6 10.2 3.2e-16 60.6 10.2 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDF34615.1 - 5e-08 32.9 0.2 1.3e-07 31.5 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF34615.1 - 1.9e-07 30.6 0.0 2.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 CDF34615.1 - 0.00061 19.7 0.1 0.0038 17.1 0.1 2.2 2 0 0 2 2 2 1 Serine hydrolase Thioesterase PF00975.20 CDF34615.1 - 0.056 13.6 0.0 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Thioesterase domain Peptidase_S8 PF00082.22 CDF34616.1 - 9.2e-28 97.3 0.5 9.2e-28 97.3 0.5 4.8 4 1 0 4 4 4 1 Subtilase family UvrC_HhH_N PF08459.11 CDF34617.1 - 0.059 13.3 0.1 0.14 12.0 0.1 1.6 1 1 1 2 2 2 0 UvrC Helix-hairpin-helix N-terminal ESSS PF10183.9 CDF34618.1 - 0.069 13.4 0.0 0.08 13.2 0.0 1.2 1 1 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ribosomal_L7Ae PF01248.26 CDF34621.1 - 9.5e-28 95.8 0.9 1.3e-27 95.4 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ATP_bind_3 PF01171.20 CDF34622.1 - 3.5e-15 56.2 0.0 6.6e-15 55.3 0.0 1.5 1 1 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 CDF34622.1 - 3.6e-13 48.8 2.3 3.6e-13 48.8 2.3 3.4 4 0 0 4 4 4 1 Zinc-ribbon CTU2 PF10288.9 CDF34622.1 - 0.011 16.0 2.0 0.034 14.4 0.1 2.5 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 RecR PF02132.15 CDF34622.1 - 0.013 15.0 1.0 0.013 15.0 1.0 3.4 3 1 0 3 3 3 0 RecR protein zf-UBR PF02207.20 CDF34622.1 - 0.8 9.9 6.2 3.2 8.0 0.8 2.4 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) DZR PF12773.7 CDF34622.1 - 1.1 9.3 11.2 4 7.5 2.1 2.9 3 0 0 3 3 3 0 Double zinc ribbon TF_Zn_Ribbon PF08271.12 CDF34622.1 - 1.8 8.1 11.3 0.32 10.5 0.5 3.3 3 0 0 3 3 3 0 TFIIB zinc-binding DAD PF02109.16 CDF34624.1 - 0.066 13.5 0.0 0.081 13.2 0.0 1.0 1 0 0 1 1 1 0 DAD family SBBP PF06739.11 CDF34625.1 - 0.0076 16.2 8.0 0.0088 16.0 0.0 4.6 6 0 0 6 6 6 1 Beta-propeller repeat Hydrolase_4 PF12146.8 CDF34626.1 - 6e-61 205.8 0.4 7.4e-61 205.4 0.4 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDF34626.1 - 4.1e-09 37.4 5.8 4.1e-09 37.4 5.8 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDF34626.1 - 1.7e-07 31.2 0.7 1.3e-06 28.3 0.7 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CDF34626.1 - 7.2e-06 25.8 0.7 0.0039 16.8 1.0 2.4 2 1 1 3 3 3 2 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CDF34626.1 - 0.0001 21.9 0.0 0.08 12.5 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Ser_hydrolase PF06821.13 CDF34626.1 - 0.0014 18.6 0.1 0.0042 17.0 0.0 1.9 2 0 0 2 2 2 1 Serine hydrolase Abhydro_lipase PF04083.16 CDF34626.1 - 0.019 14.5 0.3 0.075 12.6 0.1 2.3 2 1 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Esterase PF00756.20 CDF34626.1 - 0.062 12.9 0.0 0.14 11.8 0.0 1.7 1 1 0 1 1 1 0 Putative esterase Chlorophyllase2 PF12740.7 CDF34626.1 - 0.14 11.1 0.0 0.27 10.1 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Esterase PF00756.20 CDF34627.1 - 6.9e-50 170.0 0.0 9e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 CDF34627.1 - 3.9e-05 23.0 0.0 8.2e-05 22.0 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDF34627.1 - 0.0046 17.6 0.0 0.0062 17.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.11 CDF34627.1 - 0.03 13.3 0.0 0.052 12.5 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Peptidase_S9 PF00326.21 CDF34627.1 - 0.043 13.3 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDF34627.1 - 0.065 12.9 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDF34627.1 - 0.093 12.5 0.0 0.57 9.9 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 CDF34627.1 - 0.13 11.8 0.2 1.3 8.5 0.2 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family zf-CCHH PF10283.9 CDF34627.1 - 0.19 11.7 1.0 0.42 10.6 1.0 1.5 1 0 0 1 1 1 0 PBZ domain GLTP PF08718.11 CDF34628.1 - 5.7e-28 98.1 0.0 8.3e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) ATP-grasp_3 PF02655.14 CDF34628.1 - 0.0072 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Helicase_C_2 PF13307.6 CDF34629.1 - 1.6e-42 145.6 0.0 3.3e-42 144.6 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDF34629.1 - 1.4e-38 132.3 0.1 8e-38 129.8 0.1 2.1 1 1 0 1 1 1 1 DEAD_2 ResIII PF04851.15 CDF34629.1 - 0.00011 22.3 0.1 0.065 13.2 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF34629.1 - 0.013 15.3 1.3 0.19 11.5 1.3 2.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_11 PF13086.6 CDF34629.1 - 0.016 15.0 1.0 0.05 13.4 0.1 2.1 1 1 1 2 2 2 0 AAA domain PhoH PF02562.16 CDF34629.1 - 0.025 14.0 0.1 0.66 9.4 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein T2SSE PF00437.20 CDF34629.1 - 0.029 13.4 0.0 0.16 11.0 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein tRNA-synt_2c PF01411.19 CDF34631.1 - 3.2e-184 613.5 0.0 1.5e-182 608.0 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 CDF34631.1 - 7.3e-18 65.3 3.9 7.3e-18 65.3 3.9 2.0 2 0 0 2 2 2 1 DHHA1 domain tRNA_SAD PF07973.14 CDF34631.1 - 1.9e-17 63.1 0.1 4.8e-17 61.8 0.1 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Peptidase_M41 PF01434.18 CDF34632.1 - 1.1e-58 198.3 0.0 1.7e-58 197.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CDF34632.1 - 6e-42 143.2 0.0 1.1e-41 142.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF34632.1 - 1.8e-12 46.8 0.9 5.1e-12 45.4 0.9 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDF34632.1 - 0.0001 22.3 0.0 0.00055 19.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDF34632.1 - 0.0018 18.0 0.0 0.004 16.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 CDF34632.1 - 0.0022 17.2 0.0 0.0062 15.8 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 CDF34632.1 - 0.0033 17.7 0.0 0.85 9.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 CDF34632.1 - 0.017 15.3 0.0 0.1 12.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 CDF34632.1 - 0.019 14.3 0.2 0.059 12.8 0.2 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CDF34632.1 - 0.026 14.9 0.1 0.5 10.7 0.2 2.5 1 1 1 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CDF34632.1 - 0.048 13.8 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CDF34632.1 - 0.052 14.0 0.1 0.19 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain BING4CT PF08149.11 CDF34632.1 - 0.11 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 BING4CT (NUC141) domain FA_FANCE PF11510.8 CDF34633.1 - 0.00041 19.8 0.0 0.00047 19.6 0.0 1.1 1 0 0 1 1 1 1 Fanconi Anaemia group E protein FANCE GNAT_like PF18407.1 CDF34633.1 - 2.3 8.6 8.7 0.26 11.7 3.1 2.3 2 1 1 3 3 3 0 GCN5-related N-acetyltransferase like domain Tic110 PF16940.5 CDF34634.1 - 5.1e-38 130.9 20.7 1.2e-17 63.7 0.2 5.2 3 1 2 5 5 5 5 Chloroplast envelope transporter DUF4299 PF14132.6 CDF34634.1 - 0.021 14.3 0.1 0.037 13.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) HLH PF00010.26 CDF34634.1 - 0.059 13.3 0.1 3.2 7.8 0.0 3.1 3 0 0 3 3 3 0 Helix-loop-helix DNA-binding domain Cbl_N PF02262.16 CDF34634.1 - 0.078 13.0 0.5 2 8.4 0.0 2.8 2 1 1 3 3 3 0 CBL proto-oncogene N-terminal domain 1 MMR_HSR1_Xtn PF16897.5 CDF34635.1 - 1.6e-38 131.0 1.5 2.6e-38 130.3 1.5 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 CDF34635.1 - 3.2e-20 72.3 0.0 6.2e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 CDF34635.1 - 1.5e-13 50.5 0.0 3.6e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 CDF34635.1 - 1.1e-11 44.4 0.3 4.8e-11 42.4 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDF34635.1 - 2.8e-05 24.3 0.1 0.19 11.8 0.0 2.4 1 1 1 2 2 2 2 Dynamin family Aminotran_1_2 PF00155.21 CDF34636.1 - 1.3e-35 123.2 0.0 2.1e-35 122.6 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 CDF34636.1 - 5.7e-07 28.7 0.0 5.9e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 Allinase Pkinase PF00069.25 CDF34638.1 - 1.8e-58 198.0 0.1 2.2e-58 197.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34638.1 - 1.7e-18 66.9 0.0 2.3e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF34638.1 - 2.4e-05 24.4 0.0 6e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF34638.1 - 0.023 14.0 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDF34638.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Na_H_Exchanger PF00999.21 CDF34641.1 - 1.8e-57 194.9 39.7 2.8e-57 194.2 39.7 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family AAA_12 PF13087.6 CDF34642.1 - 5.6e-27 94.7 0.0 1.2e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNase_H_2 PF13482.6 CDF34642.1 - 4.3e-19 69.1 0.0 7.7e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 RNase_H superfamily AAA_11 PF13086.6 CDF34642.1 - 4e-15 56.3 1.3 1.1e-07 32.0 0.2 2.9 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 CDF34642.1 - 7.7e-11 42.1 0.0 9.5e-10 38.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CDF34642.1 - 1.3e-07 31.6 0.8 0.00075 19.3 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CDF34642.1 - 5e-07 30.2 0.0 1.5e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 CDF34642.1 - 1.2e-06 28.5 0.1 2.9e-05 24.0 0.1 2.7 2 1 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 CDF34642.1 - 5e-05 23.0 0.0 0.025 14.4 0.0 2.7 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain T2SSE PF00437.20 CDF34642.1 - 0.00082 18.5 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 CDF34642.1 - 0.016 14.5 0.0 0.099 11.9 0.0 2.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 CDF34642.1 - 0.036 14.1 0.0 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CDF34642.1 - 0.061 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ResIII PF04851.15 CDF34642.1 - 0.063 13.3 0.0 0.24 11.4 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit NACHT PF05729.12 CDF34642.1 - 0.088 12.7 0.2 0.43 10.5 0.0 2.3 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 CDF34642.1 - 0.11 12.1 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 CDF34642.1 - 0.12 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 CDF34642.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 CDF34642.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 CDF34642.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Malectin PF11721.8 CDF34643.1 - 3.4e-34 118.3 0.0 1.8e-16 60.7 0.0 2.4 2 0 0 2 2 2 2 Malectin domain TIG PF01833.24 CDF34643.1 - 1.4e-20 73.1 14.6 6.1e-12 45.4 0.7 3.7 3 0 0 3 3 3 2 IPT/TIG domain GSDH PF07995.11 CDF34643.1 - 5.5e-08 32.5 0.0 1.5e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Malectin_like PF12819.7 CDF34643.1 - 1e-05 24.9 0.0 0.02 14.1 0.0 2.2 2 0 0 2 2 2 2 Malectin-like domain PA14 PF07691.12 CDF34643.1 - 0.0092 15.8 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 1 PA14 domain PQQ_3 PF13570.6 CDF34643.1 - 0.21 12.1 5.7 0.58 10.7 0.2 3.5 3 0 0 3 3 3 0 PQQ-like domain ERGIC_N PF13850.6 CDF34644.1 - 0.06 13.7 0.2 2 8.8 0.0 2.5 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF1295 PF06966.12 CDF34647.1 - 1.5e-30 106.5 1.0 1.7e-30 106.3 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CDF34647.1 - 0.0015 18.9 0.2 0.0045 17.4 0.0 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 CDF34647.1 - 0.0056 16.7 0.8 0.01 15.9 0.8 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CDF34647.1 - 0.022 15.2 0.1 0.04 14.3 0.1 1.4 1 0 0 1 1 1 0 Phospholipid methyltransferase Abhydrolase_6 PF12697.7 CDF34648.1 - 1e-06 29.5 3.4 1.4e-06 29.1 3.4 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family DapB_C PF05173.14 CDF34649.1 - 1.9e-19 69.9 0.2 3.1e-19 69.2 0.2 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, C-terminus DapB_N PF01113.20 CDF34649.1 - 1.9e-12 47.4 0.1 3.8e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Scramblase PF03803.15 CDF34651.1 - 2e-25 89.4 0.1 2.8e-25 88.9 0.1 1.1 1 0 0 1 1 1 1 Scramblase Scramblase PF03803.15 CDF34652.1 - 2.6e-07 30.2 0.0 3.9e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Scramblase DUF702 PF05142.12 CDF34652.1 - 0.045 14.2 0.1 0.072 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) SRP54 PF00448.22 CDF34653.1 - 9.5e-76 253.8 0.3 2.4e-75 252.5 0.1 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CDF34653.1 - 3.1e-29 101.5 1.8 3.1e-29 101.5 1.8 2.9 4 0 0 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 CDF34653.1 - 2.7e-20 72.4 3.6 2.7e-20 72.4 3.6 2.0 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 CDF34653.1 - 4.7e-05 23.6 0.0 9.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 CDF34653.1 - 0.00052 19.6 0.2 0.0035 16.9 0.2 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 CDF34653.1 - 0.02 14.2 0.0 0.048 12.9 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin SRPRB PF09439.10 CDF34653.1 - 0.026 14.0 0.1 0.56 9.6 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF5601 PF18151.1 CDF34653.1 - 0.77 10.1 2.8 1.3 9.3 0.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5601) DUF2209 PF09974.9 CDF34653.1 - 0.77 10.1 4.2 0.27 11.6 0.2 2.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2209) ADH_N PF08240.12 CDF34654.1 - 1.2e-19 70.2 0.0 2e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 CDF34654.1 - 9.6e-08 31.8 0.0 1.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N PF00107.26 CDF34654.1 - 6.1e-07 29.5 0.1 1.5e-06 28.2 0.1 1.7 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDF34654.1 - 0.01 16.9 0.0 0.034 15.2 0.0 1.8 2 1 0 2 2 2 0 Zinc-binding dehydrogenase ApbA PF02558.16 CDF34654.1 - 0.017 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NifU PF01106.17 CDF34655.1 - 0.12 12.6 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 NifU-like domain Yuri_gagarin PF15934.5 CDF34656.1 - 0.0023 17.8 6.9 0.74 9.6 0.0 2.3 2 0 0 2 2 2 2 Yuri gagarin OmpH PF03938.14 CDF34656.1 - 0.077 13.3 3.5 0.61 10.4 4.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FUSC PF04632.12 CDF34656.1 - 0.13 10.8 3.9 1 7.8 0.1 2.3 1 1 1 2 2 2 0 Fusaric acid resistance protein family Fib_alpha PF08702.10 CDF34656.1 - 0.13 12.4 7.2 3.7 7.7 4.2 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 CDF34656.1 - 0.15 12.0 3.7 1.5 8.8 0.0 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor MCPsignal PF00015.21 CDF34656.1 - 0.32 10.8 6.8 0.69 9.7 0.2 3.1 2 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4407 PF14362.6 CDF34656.1 - 0.44 9.9 12.0 0.63 9.3 9.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) YabA PF06156.13 CDF34656.1 - 0.59 10.8 8.0 2.3 8.9 3.1 3.1 2 1 1 3 3 3 0 Initiation control protein YabA SlyX PF04102.12 CDF34656.1 - 0.8 10.4 7.0 28 5.4 1.0 3.8 3 2 0 3 3 3 0 SlyX Cob_adeno_trans PF01923.18 CDF34656.1 - 1.2 9.2 7.2 24 5.0 7.2 2.6 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Tetraspanin PF00335.20 CDF34657.1 - 2.6e-11 43.7 9.5 2.9e-11 43.5 9.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2981 PF11200.8 CDF34657.1 - 0.087 12.6 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SUR7 PF06687.12 CDF34657.1 - 0.35 10.5 11.8 0.085 12.5 3.2 2.1 2 0 0 2 2 2 0 SUR7/PalI family TMEM43 PF07787.12 CDF34657.1 - 9.2 5.6 6.1 16 4.8 6.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 ALAD PF00490.21 CDF34658.1 - 3.3e-136 453.6 0.0 3.8e-136 453.4 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase PRAI PF00697.22 CDF34659.1 - 2.3e-27 96.0 0.0 2.8e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase DUF2781 PF10914.8 CDF34661.1 - 2 8.8 14.0 8.1 6.8 14.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2781) Cmc1 PF08583.10 CDF34662.1 - 3.1e-14 52.7 0.1 5.2e-14 52.0 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like eIF2A PF08662.11 CDF34663.1 - 4.9e-48 163.6 0.2 3.5e-43 147.8 0.3 2.5 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 CDF34663.1 - 2.9e-07 30.7 0.0 0.51 10.7 0.0 5.1 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 CDF34663.1 - 4.9e-05 21.6 0.1 8.1e-05 20.8 0.1 1.3 1 0 0 1 1 1 1 IKI3 family RRM_1 PF00076.22 CDF34663.1 - 0.0072 16.1 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CDF34663.1 - 0.015 16.1 5.3 19 6.3 0.5 5.9 7 0 0 7 7 7 0 WD domain, G-beta repeat OmpH PF03938.14 CDF34663.1 - 2.9 8.2 7.8 7.6 6.9 4.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DNA_primase_lrg PF04104.14 CDF34664.1 - 3.4e-66 223.4 0.0 4.5e-66 223.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit FPL PF09758.9 CDF34665.1 - 2.8e-42 144.2 0.9 1.1e-34 119.6 0.5 2.7 2 0 0 2 2 2 2 Uncharacterised conserved protein SOG2 PF10428.9 CDF34665.1 - 4.1 6.5 9.9 0.24 10.6 2.6 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein ATP-synt_S1 PF05827.12 CDF34666.1 - 0.08 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) PrmA PF06325.13 CDF34667.1 - 1.6e-11 44.2 0.3 3.2e-11 43.2 0.3 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDF34667.1 - 6.8e-11 42.7 0.0 2.3e-10 41.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF34667.1 - 7.3e-10 38.8 0.4 7.5e-09 35.6 0.4 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF34667.1 - 1e-08 35.7 0.0 3.8e-08 33.9 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CDF34667.1 - 5.1e-07 29.4 0.1 8e-07 28.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CDF34667.1 - 1.5e-06 27.7 0.1 2.6e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 CDF34667.1 - 4.2e-06 26.8 0.0 6.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF34667.1 - 8.7e-06 26.4 0.0 1.6e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF34667.1 - 3.5e-05 23.7 0.0 6.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDF34667.1 - 0.00088 19.1 0.1 0.0014 18.4 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TehB PF03848.14 CDF34667.1 - 0.0011 18.4 0.7 0.0028 17.1 0.1 1.9 2 1 0 2 2 2 1 Tellurite resistance protein TehB PRMT5 PF05185.16 CDF34667.1 - 0.0015 18.4 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_9 PF08003.11 CDF34667.1 - 0.0033 16.4 0.0 0.0052 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Cons_hypoth95 PF03602.15 CDF34667.1 - 0.0095 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 CDF34667.1 - 0.013 15.5 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CDF34667.1 - 0.024 14.0 0.1 0.036 13.4 0.1 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 CDF34667.1 - 0.028 13.7 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain PCMT PF01135.19 CDF34667.1 - 0.032 14.0 0.1 0.05 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 CDF34667.1 - 0.036 13.8 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase FtsJ PF01728.19 CDF34667.1 - 0.05 13.7 0.0 0.086 13.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase UPF0020 PF01170.18 CDF34667.1 - 0.066 12.9 0.3 0.7 9.5 0.3 2.1 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 DOT1 PF08123.13 CDF34667.1 - 0.11 12.0 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 GCD14 PF08704.10 CDF34667.1 - 0.15 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit CBS PF00571.28 CDF34668.1 - 3.4e-21 75.4 4.0 1.1e-12 48.2 0.3 3.0 3 1 0 3 3 3 2 CBS domain Oxidored_molyb PF00174.19 CDF34669.1 - 3.3e-58 196.1 0.0 5.2e-58 195.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CDF34669.1 - 1.8e-41 141.4 0.0 3.5e-41 140.5 0.0 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain FAD_binding_6 PF00970.24 CDF34669.1 - 2.4e-33 114.4 0.0 5.5e-33 113.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CDF34669.1 - 1.1e-28 100.0 0.0 3.1e-28 98.6 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 CDF34669.1 - 2.1e-23 82.2 0.1 4.9e-23 81.1 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 CDF34669.1 - 0.0024 18.0 0.0 0.0052 16.9 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Oxidored_molyb PF00174.19 CDF34670.1 - 5.3e-54 182.4 0.0 9.7e-54 181.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CDF34670.1 - 3.5e-41 140.4 0.1 7.3e-41 139.4 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain FAD_binding_6 PF00970.24 CDF34670.1 - 1e-33 115.6 0.0 2.8e-33 114.2 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CDF34670.1 - 7e-25 87.8 0.0 3.5e-24 85.5 0.0 2.2 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 CDF34670.1 - 5.1e-22 77.8 0.1 1.1e-21 76.8 0.1 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 CDF34670.1 - 0.00032 20.8 0.0 0.0012 19.0 0.0 2.0 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 CDF34670.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain zf-CCCH PF00642.24 CDF34671.1 - 2.5e-12 46.4 17.0 4.3e-07 29.7 2.4 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 CDF34671.1 - 7.8e-07 28.8 0.0 8.2e-06 25.6 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CDF34671.1 - 8.6e-07 28.8 15.8 0.0033 17.4 2.6 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 CDF34671.1 - 0.021 15.5 4.2 0.65 10.7 0.2 2.5 2 0 0 2 2 2 0 Torus domain zf-CCCH_3 PF15663.5 CDF34671.1 - 0.072 13.3 5.4 2.4 8.4 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 CDF34671.1 - 9.9 6.8 12.8 4.3 8.0 4.1 3.2 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Coatomer_E PF04733.14 CDF34673.1 - 2.5e-85 286.4 2.4 2.8e-85 286.3 2.4 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 CDF34673.1 - 1e-09 38.8 2.2 3e-06 27.6 0.0 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF34673.1 - 4.4e-08 32.6 0.5 0.0035 17.3 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF34673.1 - 4.6e-08 33.2 1.0 0.24 12.3 0.1 5.2 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF34673.1 - 1.1e-07 32.0 0.2 0.00015 22.0 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDF34673.1 - 2.4e-07 30.3 1.0 0.00079 19.2 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF34673.1 - 1e-05 25.2 0.6 0.23 11.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF34673.1 - 2.8e-05 24.5 0.0 5 8.0 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF34673.1 - 0.00032 20.9 0.2 0.44 10.8 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 CDF34673.1 - 0.00047 20.5 1.3 0.041 14.5 0.2 3.4 4 0 0 4 4 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDF34673.1 - 0.012 15.4 1.5 6.7 6.7 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDF34673.1 - 0.015 15.5 0.1 2.5 8.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF34673.1 - 0.039 14.6 0.7 2.3 9.0 0.0 3.2 4 0 0 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF34673.1 - 0.1 12.6 0.1 2.4 8.3 0.1 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat tRNA-synt_1e PF01406.19 CDF34674.1 - 5.2e-95 318.3 0.0 8.2e-95 317.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDF34674.1 - 5.2e-10 38.6 0.0 0.00073 18.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 CDF34674.1 - 3.9e-06 27.2 0.1 8.9e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 DALR domain tRNA-synt_1c PF00749.21 CDF34674.1 - 0.00021 20.3 0.0 0.00046 19.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1 PF00133.22 CDF34674.1 - 0.0043 15.4 0.0 0.011 14.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) DUF4349 PF14257.6 CDF34674.1 - 0.083 12.3 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) HTH_Tnp_Tc3_1 PF11427.8 CDF34675.1 - 4.7e-07 29.5 0.1 1.2e-06 28.2 0.1 1.7 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF34675.1 - 1.3e-05 24.9 3.3 2.5e-05 23.9 0.1 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_11 PF08279.12 CDF34675.1 - 0.013 15.4 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 HTH domain HTH_23 PF13384.6 CDF34675.1 - 0.018 14.8 2.0 0.23 11.3 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF34675.1 - 0.041 14.1 0.8 0.041 14.1 0.8 2.1 2 0 0 2 2 2 0 Transposase HTH_29 PF13551.6 CDF34675.1 - 0.088 12.8 1.5 0.19 11.7 0.1 2.3 2 1 0 2 2 2 0 Winged helix-turn helix NIR_SIR PF01077.22 CDF34676.1 - 3e-52 176.3 0.0 1.2e-42 145.1 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CDF34676.1 - 3.6e-28 97.2 0.0 9.5e-15 54.2 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain PaREP1 PF05942.11 CDF34676.1 - 0.17 11.8 0.0 26 4.8 0.0 2.5 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family Hemerythrin PF01814.23 CDF34678.1 - 0.0093 16.6 0.0 0.021 15.4 0.0 1.7 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DNA_pol3_delta2 PF13177.6 CDF34679.1 - 4.9e-14 52.4 0.0 9.6e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CDF34679.1 - 6.6e-05 22.9 0.0 0.00017 21.6 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 CDF34679.1 - 9.4e-05 22.8 0.6 0.0004 20.8 0.6 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 CDF34679.1 - 0.0017 18.7 0.0 0.005 17.2 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_16 PF13191.6 CDF34679.1 - 0.018 15.5 0.1 0.078 13.4 0.0 2.2 1 1 0 2 2 2 0 AAA ATPase domain DNA_pol3_delta PF06144.13 CDF34679.1 - 0.041 13.7 0.0 0.34 10.7 0.0 2.3 3 0 0 3 3 3 0 DNA polymerase III, delta subunit Sigma54_activ_2 PF14532.6 CDF34679.1 - 0.096 12.8 0.2 2.1 8.4 0.1 2.7 1 1 2 3 3 3 0 Sigma-54 interaction domain RuvB_N PF05496.12 CDF34679.1 - 0.13 12.1 0.0 2.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Pkinase PF00069.25 CDF34680.1 - 1.2e-64 218.2 0.0 1.4e-64 218.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34680.1 - 5.6e-34 117.6 0.0 6.6e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF34680.1 - 0.00013 21.4 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF34680.1 - 0.00035 20.6 0.1 0.0009 19.2 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF34680.1 - 0.0055 16.3 0.0 0.0091 15.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 CDF34680.1 - 0.027 13.8 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like SapA PF02199.15 CDF34680.1 - 5.1 7.5 5.4 16 5.9 0.1 3.5 4 0 0 4 4 4 0 Saposin A-type domain Transketolase_C PF02780.20 CDF34682.1 - 3.6e-24 85.0 0.0 5.1e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CDF34683.1 - 4.9e-20 71.9 0.0 6.7e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CDF34683.1 - 1.3e-13 50.8 2.0 2.2e-12 46.8 0.0 2.8 3 1 1 4 4 4 2 1-deoxy-D-xylulose-5-phosphate synthase DUF1995 PF09353.10 CDF34687.1 - 2.4e-14 53.8 0.0 3.5e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) SURF2 PF05477.11 CDF34689.1 - 3.8e-19 69.3 10.2 8e-19 68.3 9.9 1.9 1 1 0 1 1 1 1 Surfeit locus protein 2 (SURF2) Kisspeptin PF15152.6 CDF34689.1 - 0.097 13.5 0.1 0.47 11.3 0.1 2.2 1 0 0 1 1 1 0 Kisspeptin Dynamin_M PF01031.20 CDF34690.1 - 2.3e-94 315.8 0.0 4e-94 315.0 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CDF34690.1 - 1e-48 165.6 0.2 2.5e-48 164.3 0.2 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CDF34690.1 - 1e-23 83.3 3.4 2.8e-23 81.9 3.4 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CDF34690.1 - 0.00033 20.7 0.3 0.0016 18.5 0.3 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase CLP_protease PF00574.23 CDF34691.1 - 4.4e-80 267.9 0.0 5.4e-80 267.6 0.0 1.1 1 0 0 1 1 1 1 Clp protease CLP_protease PF00574.23 CDF34692.1 - 1.2e-34 119.8 0.0 1.7e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 Clp protease Carboxyl_trans PF01039.22 CDF34696.1 - 1.7e-154 515.1 0.0 2.3e-154 514.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 CDF34696.1 - 4.1e-129 432.0 0.3 1e-90 305.0 0.0 2.9 2 1 0 2 2 2 2 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 CDF34696.1 - 2.4e-49 167.7 0.0 4.3e-49 166.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDF34696.1 - 2.1e-28 99.1 0.0 5.4e-28 97.7 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDF34696.1 - 5.1e-22 78.0 0.0 1.4e-21 76.7 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDF34696.1 - 8.7e-11 41.5 0.0 2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 CDF34696.1 - 1.4e-05 24.7 0.1 2.9e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CDF34696.1 - 2.6e-05 24.4 0.0 5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDF34696.1 - 0.0026 17.3 0.0 0.0063 16.1 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CDF34696.1 - 0.047 13.5 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 Biotin-lipoyl like Spt20 PF12090.8 CDF34697.1 - 0.086 12.4 0.4 0.11 12.1 0.4 1.1 1 0 0 1 1 1 0 Spt20 family DUF680 PF05079.12 CDF34697.1 - 0.092 13.5 1.4 0.33 11.7 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF680) Rib_5-P_isom_A PF06026.14 CDF34698.1 - 8.7e-10 38.5 0.1 1.7e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Pterin_4a PF01329.19 CDF34698.1 - 6.5e-09 35.8 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase OB_NTP_bind PF07717.16 CDF34700.1 - 4.5e-13 49.4 0.4 6.8e-12 45.6 0.0 2.7 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CDF34700.1 - 3.6e-08 33.6 0.0 7.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDF34700.1 - 2e-06 28.1 0.1 7.2e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DOMON PF03351.17 CDF34702.1 - 2.7e-23 82.5 0.2 5e-09 36.4 0.0 3.4 3 0 0 3 3 3 3 DOMON domain Cytochrom_B561 PF03188.16 CDF34702.1 - 1.5e-06 28.4 7.5 1.5e-06 28.4 7.5 1.6 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF568 PF04526.13 CDF34702.1 - 0.00072 20.2 0.0 0.0099 16.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF568) DUF2427 PF10348.9 CDF34702.1 - 0.029 14.2 4.0 0.072 12.9 4.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) INTAP PF16617.5 CDF34703.1 - 0.99 9.8 6.4 1.2 9.5 6.1 1.4 1 1 0 1 1 1 0 Intersectin and clathrin adaptor AP2 binding region Pkinase PF00069.25 CDF34704.1 - 1.6e-62 211.2 0.0 2e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34704.1 - 9.8e-41 139.7 0.0 1.2e-40 139.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34704.1 - 2.8e-07 30.2 0.0 4.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDF34704.1 - 7e-05 22.9 0.3 0.00021 21.3 0.1 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF34704.1 - 0.00012 21.5 0.0 0.00038 19.9 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF34704.1 - 0.00086 18.2 0.0 0.0013 17.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 CDF34704.1 - 0.0027 17.4 0.0 0.028 14.1 0.0 2.0 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 CDF34704.1 - 0.052 12.5 0.0 0.078 11.9 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 CDF34704.1 - 0.21 11.2 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase BOP1NT PF08145.12 CDF34706.1 - 3.4e-84 282.8 5.2 5.3e-84 282.2 5.2 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 CDF34706.1 - 3.8e-13 49.7 12.0 4.9e-05 24.0 0.1 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34706.1 - 3e-05 24.2 0.0 1.2 9.5 0.0 4.6 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain ABC_membrane_2 PF06472.15 CDF34707.1 - 2.3e-61 207.6 5.8 3e-61 207.2 5.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDF34707.1 - 1.1e-16 61.5 0.0 2.9e-16 60.2 0.0 1.7 2 0 0 2 2 1 1 ABC transporter SbmA_BacA PF05992.12 CDF34707.1 - 4.7e-12 46.0 9.2 2e-11 43.9 9.2 1.8 1 1 0 1 1 1 1 SbmA/BacA-like family AAA_30 PF13604.6 CDF34707.1 - 5e-05 23.1 0.0 0.00061 19.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 CDF34707.1 - 0.0016 18.4 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_21 PF13304.6 CDF34707.1 - 0.0025 17.7 0.1 0.0077 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDF34707.1 - 0.0045 17.4 0.0 0.0096 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 CDF34707.1 - 0.0047 16.4 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF34707.1 - 0.0088 15.8 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDF34707.1 - 0.019 15.3 0.2 0.084 13.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDF34707.1 - 0.036 14.0 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 CDF34707.1 - 0.062 13.8 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDF34707.1 - 0.11 12.9 0.1 0.4 11.1 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CDF34707.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_27 PF13514.6 CDF34707.1 - 0.17 11.5 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 CDF34707.1 - 0.3 10.7 11.3 0.69 9.5 11.3 1.5 1 1 0 1 1 1 0 ABC transporter transmembrane region zf-C2H2 PF00096.26 CDF34709.1 - 1.4e-12 47.3 17.7 0.00055 20.2 0.0 5.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF34709.1 - 1.2e-10 41.3 12.6 0.00012 22.3 0.5 5.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF34709.1 - 6.3e-09 35.9 16.3 0.019 15.8 0.1 5.0 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 CDF34709.1 - 0.00048 20.4 2.7 0.00048 20.4 2.7 2.9 3 0 0 3 3 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 CDF34709.1 - 0.0092 15.7 3.6 0.0092 15.7 3.6 4.2 4 1 0 4 4 4 1 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 CDF34709.1 - 0.022 15.4 10.4 0.045 14.4 0.6 3.4 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats FOXP-CC PF16159.5 CDF34709.1 - 0.032 14.9 2.8 14 6.4 0.1 3.9 1 1 2 3 3 3 0 FOXP coiled-coil domain zf_ZIC PF18366.1 CDF34709.1 - 0.081 13.0 0.0 0.81 9.8 0.0 2.5 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_jaz PF12171.8 CDF34709.1 - 0.088 13.1 0.3 7.1 7.1 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CDF34709.1 - 0.15 11.8 14.6 0.28 11.0 0.4 3.6 4 0 0 4 4 4 0 C2H2-type zinc-finger domain FSA_C PF10479.9 CDF34709.1 - 0.28 9.3 3.2 0.78 7.8 3.2 1.6 1 1 0 1 1 1 0 Fragile site-associated protein C-terminus zf-met PF12874.7 CDF34709.1 - 0.72 10.3 2.7 45 4.6 0.2 3.7 4 0 0 4 4 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDF34709.1 - 5.5 7.4 9.5 15 6.0 3.1 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Elf1 PF05129.13 CDF34709.1 - 8.4 6.5 9.8 9.1 6.4 1.7 2.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like E2F_TDP PF02319.20 CDF34710.1 - 1.3e-19 70.0 0.4 2.7e-19 69.0 0.4 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.10 CDF34710.1 - 1.6e-14 53.9 2.1 9.2e-14 51.5 1.5 2.4 2 1 0 2 2 2 1 Transcription factor DP TrmB PF01978.19 CDF34710.1 - 0.073 13.0 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB CDV3 PF15359.6 CDF34710.1 - 2.7 8.5 6.9 5.6 7.5 6.9 1.5 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 WD40 PF00400.32 CDF34712.1 - 5.7e-21 74.4 10.1 3.9e-07 30.6 0.3 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34712.1 - 1.1e-10 41.6 1.7 0.00023 21.4 0.1 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF34712.1 - 5.5e-07 28.9 0.0 4.6e-05 22.6 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CDF34712.1 - 0.0034 17.3 0.1 0.008 16.1 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CDF34712.1 - 0.024 13.3 0.1 0.03 13.0 0.1 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 DUF1823 PF08853.11 CDF34714.1 - 9.5e-28 96.7 0.2 1.3e-27 96.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1823) Metallophos PF00149.28 CDF34715.1 - 2.1e-13 51.2 1.0 3.3e-13 50.6 1.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF34715.1 - 5.4e-09 36.4 0.2 2.3e-07 31.2 0.2 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LID PF17916.1 CDF34715.1 - 0.055 13.1 2.3 11 5.7 0.0 3.9 4 0 0 4 4 4 0 LIM interaction domain (LID) TPR_19 PF14559.6 CDF34716.1 - 1.2 9.7 4.2 37 4.9 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF34716.1 - 1.3 9.3 6.4 1.2e+02 3.2 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Cep57_MT_bd PF06657.13 CDF34716.1 - 3.8 8.0 9.6 4.6 7.8 3.9 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Tropomyosin PF00261.20 CDF34716.1 - 9.2 5.6 37.4 7.4 5.9 25.1 2.5 1 1 1 2 2 2 0 Tropomyosin DUF3598 PF12204.8 CDF34717.1 - 5.1e-10 39.3 0.0 1.3e-09 38.0 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3598) HlyD PF00529.20 CDF34717.1 - 0.051 13.5 0.0 1.1 9.1 0.0 2.9 1 1 0 1 1 1 0 HlyD membrane-fusion protein of T1SS ADH_zinc_N PF00107.26 CDF34718.1 - 6.2e-26 90.9 0.1 1.6e-25 89.6 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDF34718.1 - 1.8e-14 54.9 0.0 4.2e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDF34718.1 - 0.00018 21.3 0.0 0.0018 18.1 0.0 2.4 2 2 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_25 PF13649.6 CDF34718.1 - 0.068 13.9 0.1 0.13 13.0 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Semialdhyde_dh PF01118.24 CDF34718.1 - 0.12 12.8 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Rhomboid PF01694.22 CDF34719.1 - 2.9e-20 72.8 11.4 2.9e-20 72.8 11.4 1.8 2 0 0 2 2 2 1 Rhomboid family DER1 PF04511.15 CDF34719.1 - 1.1e-06 28.7 4.3 1.9e-06 28.0 4.3 1.3 1 0 0 1 1 1 1 Der1-like family DUF1751 PF08551.10 CDF34719.1 - 0.029 14.9 1.8 0.029 14.9 1.8 1.8 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) PrmA PF06325.13 CDF34720.1 - 2.6e-14 53.3 0.1 3.8e-14 52.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CDF34720.1 - 1.7e-13 50.7 0.0 7.4e-13 48.6 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDF34720.1 - 2.6e-13 49.9 0.1 4.3e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDF34720.1 - 1.1e-10 41.5 0.0 2.1e-10 40.6 0.0 1.4 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDF34720.1 - 2.7e-09 37.6 0.5 1.5e-08 35.2 0.1 2.3 2 1 1 3 3 3 1 Methyltransferase domain UPF0020 PF01170.18 CDF34720.1 - 2.5e-08 33.9 0.5 3.1e-07 30.3 0.5 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 CDF34720.1 - 5e-06 26.2 0.0 8.4e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 CDF34720.1 - 5.1e-06 26.4 0.0 8.1e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 CDF34720.1 - 7.9e-06 25.8 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDF34720.1 - 2.1e-05 24.5 0.0 3.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF34720.1 - 3.8e-05 24.2 0.2 0.00027 21.5 0.0 2.3 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDF34720.1 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF34720.1 - 0.00027 21.6 0.0 0.00076 20.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 CDF34720.1 - 0.019 14.2 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase N6_Mtase PF02384.16 CDF34720.1 - 0.027 13.7 0.0 0.074 12.3 0.0 1.6 1 1 0 1 1 1 0 N-6 DNA Methylase Methyltransf_3 PF01596.17 CDF34720.1 - 0.028 13.6 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase PCMT PF01135.19 CDF34720.1 - 0.032 14.0 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CDF34720.1 - 0.053 12.9 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CDF34720.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase MgtC PF02308.16 CDF34722.1 - 1.7e-27 96.2 15.1 2.7e-27 95.5 15.1 1.2 1 0 0 1 1 1 1 MgtC family DEAD PF00270.29 CDF34723.1 - 2.5e-38 131.6 0.0 4.6e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF34723.1 - 2.6e-30 105.0 0.0 5.6e-30 104.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF34723.1 - 7e-05 22.9 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDF34723.1 - 0.00023 21.0 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 CDF34723.1 - 0.00091 18.6 0.0 0.0017 17.7 0.0 1.5 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 CDF34723.1 - 0.0017 18.6 0.0 0.0067 16.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF34723.1 - 0.0055 17.1 0.1 0.012 16.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF34723.1 - 0.013 15.4 0.0 0.03 14.2 0.0 1.6 1 1 0 1 1 1 0 NACHT domain DUF2457 PF10446.9 CDF34723.1 - 5.6 6.0 15.7 7.7 5.5 15.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRM_3 PF08777.11 CDF34726.1 - 8.8e-28 96.4 1.9 3.7e-27 94.3 0.1 2.1 2 0 0 2 2 2 1 RNA binding motif RRM_1 PF00076.22 CDF34726.1 - 0.05 13.4 0.1 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldose_epim PF01263.20 CDF34727.1 - 1e-35 123.5 0.0 1.3e-35 123.2 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase RNA_pol_Rpb6 PF01192.22 CDF34728.1 - 2.6e-17 62.5 0.2 3.8e-17 61.9 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 DEAD PF00270.29 CDF34729.1 - 4.9e-41 140.4 0.0 1.3e-40 139.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF34729.1 - 3.1e-19 69.4 0.0 1.1e-18 67.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDF34729.1 - 7e-13 48.6 0.1 1.4e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CDF34729.1 - 1.9e-08 34.5 0.0 5.1e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDF34729.1 - 0.035 13.3 0.0 0.081 12.1 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase 3Beta_HSD PF01073.19 CDF34730.1 - 5.3e-50 170.0 0.0 6.8e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDF34730.1 - 6.7e-22 78.1 0.0 9.8e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CDF34730.1 - 1.4e-12 47.4 0.0 1.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CDF34730.1 - 2e-12 46.8 0.0 2.7e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CDF34730.1 - 4.1e-10 39.6 0.0 1.7e-06 27.7 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CDF34730.1 - 3.6e-07 30.2 0.0 5.4e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CDF34730.1 - 0.00089 18.5 0.1 0.0036 16.5 0.1 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein MsyB PF13984.6 CDF34730.1 - 0.2 11.9 0.0 0.52 10.6 0.0 1.6 2 0 0 2 2 2 0 MsyB protein WD40 PF00400.32 CDF34732.1 - 1.8e-28 98.2 2.6 5.5e-05 23.8 0.0 8.7 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34732.1 - 2.9e-06 27.5 0.1 0.78 10.1 0.0 5.6 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF34732.1 - 0.078 11.9 0.1 19 4.1 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Porphobil_deamC PF03900.15 CDF34733.1 - 5.6e-16 58.7 0.1 7.3e-16 58.3 0.1 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Porphobil_deam PF01379.20 CDF34733.1 - 0.0078 15.7 0.0 0.014 14.9 0.1 1.4 2 0 0 2 2 2 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain NDUFV3 PF15880.5 CDF34735.1 - 1.3 9.1 4.1 2.3 8.3 4.1 1.3 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Amino_oxidase PF01593.24 CDF34736.1 - 1.3e-89 301.6 0.0 2.4e-53 182.1 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF34736.1 - 9.5e-15 54.6 0.5 2.5e-14 53.2 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDF34736.1 - 6.3e-06 25.5 1.6 1.3e-05 24.5 1.6 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDF34736.1 - 6.8e-06 25.9 4.3 3.8e-05 23.4 4.3 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CDF34736.1 - 2e-05 24.2 0.2 4.2e-05 23.1 0.2 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CDF34736.1 - 7.3e-05 22.1 0.2 0.00013 21.3 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CDF34736.1 - 0.00017 21.0 0.1 0.00046 19.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF34736.1 - 0.00061 20.3 0.3 0.002 18.7 0.3 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF34736.1 - 0.00066 18.5 0.1 0.0013 17.6 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CDF34736.1 - 0.0089 15.3 0.1 0.018 14.4 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CDF34736.1 - 0.01 15.1 0.1 0.15 11.3 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF34736.1 - 0.01 14.9 0.7 0.018 14.2 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CDF34736.1 - 0.018 14.3 1.1 0.018 14.3 1.1 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 CDF34736.1 - 0.047 13.7 0.3 0.38 10.7 0.3 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding LpxI_N PF17930.1 CDF34736.1 - 0.23 11.3 1.0 2.8 7.8 0.0 2.7 3 0 0 3 3 3 0 LpxI N-terminal domain YopH_N PF09013.10 CDF34737.1 - 0.22 11.8 0.9 1.3 9.3 0.2 2.3 2 0 0 2 2 2 0 YopH, N-terminal PD40 PF07676.12 CDF34739.1 - 0.029 14.3 2.4 0.49 10.4 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DBR1 PF05011.13 CDF34740.1 - 1.1e-15 58.3 0.0 2.1e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 CDF34740.1 - 2.2e-08 34.8 0.0 3.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF34740.1 - 6.6e-05 23.2 0.0 0.00011 22.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain WD40 PF00400.32 CDF34741.1 - 2.1e-16 60.0 4.9 2.6e-06 28.0 0.3 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34741.1 - 1.5e-06 28.4 0.2 0.00042 20.6 0.1 3.6 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF34741.1 - 0.0073 15.0 0.1 0.089 11.4 0.0 2.4 3 0 0 3 3 3 1 Nucleoporin Nup120/160 SH3_2 PF07653.17 CDF34741.1 - 0.028 14.1 0.1 0.36 10.6 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain Ribosomal_L10 PF00466.20 CDF34742.1 - 4.7e-18 65.2 0.2 8.6e-18 64.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 AnfO_nitrog PF09582.10 CDF34742.1 - 0.094 12.1 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Ribosomal_L7Ae PF01248.26 CDF34743.1 - 1.4e-11 44.0 0.0 2.6e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 CDF34743.1 - 1.3e-06 28.6 0.0 1.9e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 OTU PF02338.19 CDF34746.1 - 2.2e-23 83.1 0.0 4.6e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CDF34746.1 - 8.5e-08 31.9 0.0 0.00018 21.0 0.0 2.3 1 1 1 2 2 2 2 Peptidase C65 Otubain LEA_6 PF10714.9 CDF34747.1 - 0.02 14.9 0.3 0.073 13.1 0.3 1.9 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 Hydantoinase_B PF02538.14 CDF34748.1 - 3.3e-212 705.5 2.4 4.2e-212 705.1 2.4 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CDF34748.1 - 1.1e-100 336.7 0.2 2.8e-100 335.3 0.2 1.8 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CDF34748.1 - 1.5e-54 184.4 0.3 1.1e-52 178.3 0.0 2.5 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region GatB_Yqey PF02637.18 CDF34748.1 - 0.18 11.7 0.0 0.61 10.0 0.0 1.8 2 0 0 2 2 2 0 GatB domain Peptidase_M3 PF01432.20 CDF34749.1 - 2.6e-103 346.8 0.0 3.1e-103 346.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 DUF501 PF04417.12 CDF34751.1 - 0.08 12.7 0.2 0.08 12.7 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF501) ESCRT-II PF05871.12 CDF34753.1 - 2.3e-45 154.3 0.0 3.3e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit Transp_inhibit PF18791.1 CDF34753.1 - 0.1 12.1 0.2 0.2 11.2 0.2 1.4 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain UPF0061 PF02696.14 CDF34754.1 - 9.1e-133 443.4 0.0 1.2e-132 443.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family DUF829 PF05705.14 CDF34755.1 - 3e-28 99.4 0.1 7.8e-28 98.0 0.1 1.6 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Yae1_N PF09811.9 CDF34756.1 - 3.6e-07 29.8 2.5 5.3e-07 29.2 2.5 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal DUF2617 PF10936.8 CDF34756.1 - 0.057 13.5 0.1 1.1 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF2617 EMP24_GP25L PF01105.24 CDF34757.1 - 7.8e-23 81.4 0.0 1.1e-22 80.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD 14-3-3 PF00244.20 CDF34759.1 - 4e-99 330.6 1.5 4.6e-99 330.4 1.5 1.0 1 0 0 1 1 1 1 14-3-3 protein Abhydrolase_6 PF12697.7 CDF34760.1 - 5.1e-18 66.5 0.3 5.1e-18 66.5 0.3 2.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family DNA_photolyase PF00875.18 CDF34760.1 - 1.2e-14 54.6 1.8 1.5e-13 51.0 1.0 2.6 2 0 0 2 2 2 1 DNA photolyase Hydrolase_4 PF12146.8 CDF34760.1 - 1.9e-12 47.0 0.0 6.5e-12 45.2 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF34760.1 - 5.1e-12 46.0 0.2 8.1e-11 42.0 0.0 2.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold UPF0227 PF05728.12 CDF34760.1 - 0.0032 17.4 0.2 2.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0227) Thioesterase PF00975.20 CDF34760.1 - 0.0037 17.4 0.1 0.0077 16.4 0.1 1.5 1 0 0 1 1 1 1 Thioesterase domain Xrn1_D3 PF18194.1 CDF34760.1 - 0.069 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Exoribonuclease 1 Domain-3 His_Phos_1 PF00300.22 CDF34761.1 - 4.6e-06 26.4 0.0 7.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.25 CDF34762.1 - 2.7e-76 256.4 0.0 3.7e-76 256.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34762.1 - 5.5e-42 143.8 0.0 7.6e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF202 PF02656.15 CDF34762.1 - 1.8e-12 47.5 0.6 4.1e-12 46.4 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF202) Kinase-like PF14531.6 CDF34762.1 - 1.2e-05 24.8 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF34762.1 - 7.1e-05 22.3 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF34762.1 - 0.00079 19.4 0.7 0.17 11.8 0.1 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF34762.1 - 0.0022 16.9 0.0 0.0038 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDF34762.1 - 0.027 14.1 0.2 0.056 13.0 0.2 1.5 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 CDF34762.1 - 0.028 14.1 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 CDF34762.1 - 0.035 13.6 0.1 0.078 12.5 0.1 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL PH_8 PF15409.6 CDF34762.1 - 0.041 14.2 0.0 0.13 12.6 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Haspin_kinase PF12330.8 CDF34762.1 - 0.058 12.3 0.0 0.086 11.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Apyrase PF06079.11 CDF34763.1 - 5.6e-76 255.5 0.0 8.3e-76 255.0 0.0 1.2 1 0 0 1 1 1 1 Apyrase Cpn60_TCP1 PF00118.24 CDF34765.1 - 3.1e-146 487.9 11.2 3.6e-146 487.7 11.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Abhydrolase_6 PF12697.7 CDF34766.1 - 1.3e-27 97.8 4.9 1.3e-27 97.8 4.9 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDF34766.1 - 3.2e-16 59.8 0.2 1e-13 51.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF34766.1 - 1.3e-14 54.1 0.0 1.9e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CDF34766.1 - 2.9e-06 27.6 0.0 5.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 CDF34766.1 - 3.4e-05 23.7 0.0 5.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein LIDHydrolase PF10230.9 CDF34766.1 - 0.00013 21.7 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 CDF34766.1 - 0.0015 18.3 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CDF34766.1 - 0.0016 18.3 1.7 0.0077 16.1 1.7 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 CDF34766.1 - 0.0097 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 CDF34766.1 - 0.0099 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 CDF34766.1 - 0.012 15.4 0.7 1.3 8.8 0.7 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DUF3530 PF12048.8 CDF34766.1 - 0.018 14.5 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Peptidase_S10 PF00450.22 CDF34766.1 - 0.024 14.0 0.0 1 8.7 0.0 2.1 2 0 0 2 2 2 0 Serine carboxypeptidase Say1_Mug180 PF10340.9 CDF34766.1 - 0.045 12.6 0.0 0.069 12.0 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase DLH PF01738.18 CDF34766.1 - 0.046 13.3 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Pro_CA PF00484.19 CDF34766.1 - 0.071 13.4 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Carbonic anhydrase Peptidase_S9 PF00326.21 CDF34766.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family UBX PF00789.20 CDF34767.1 - 0.014 15.6 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 UBX domain DUF1682 PF07946.14 CDF34767.1 - 0.041 13.1 0.8 0.059 12.6 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) UIM PF02809.20 CDF34767.1 - 2.4 8.3 9.4 0.16 11.9 3.6 2.3 2 0 0 2 2 2 0 Ubiquitin interaction motif MafB19-deam PF14437.6 CDF34768.1 - 2e-25 89.1 0.0 2.3e-25 88.9 0.0 1.0 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 CDF34768.1 - 1.2e-21 76.4 0.4 1.7e-21 76.0 0.4 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.6 CDF34768.1 - 0.00077 19.6 1.3 0.002 18.2 1.3 1.6 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 CDF34768.1 - 0.03 14.4 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 DUF1487 PF07368.11 CDF34768.1 - 0.043 13.2 0.0 0.069 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) APOBEC_N PF08210.11 CDF34768.1 - 0.045 13.7 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain Inv-AAD PF18785.1 CDF34768.1 - 0.047 13.6 0.2 0.1 12.4 0.2 1.6 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase APOBEC2 PF18772.1 CDF34768.1 - 0.1 12.6 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 CDF34768.1 - 0.11 12.6 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 NB-ARC PF00931.22 CDF34773.1 - 1.1e-13 51.0 0.0 2.1e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CDF34773.1 - 0.0013 19.0 0.0 0.0048 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF4407 PF14362.6 CDF34773.1 - 0.15 11.4 0.3 0.26 10.6 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cluap1 PF10234.9 CDF34773.1 - 0.15 11.4 0.9 0.36 10.2 0.9 1.6 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF713 PF05218.14 CDF34773.1 - 0.16 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF713) rve PF00665.26 CDF34776.1 - 1.1e-23 83.6 0.0 1.5e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF34776.1 - 3.6e-06 26.7 0.1 6.2e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CDF34776.1 - 0.016 15.4 0.0 0.022 15.0 0.0 1.1 1 0 0 1 1 1 0 DDE domain WD40 PF00400.32 CDF34778.1 - 1.1e-63 209.7 29.5 3.2e-08 34.1 0.7 9.5 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34778.1 - 3.8e-17 62.4 12.0 0.0055 17.0 0.0 8.7 2 1 7 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF34778.1 - 5.5e-13 48.7 0.0 1.1e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Nup160 PF11715.8 CDF34778.1 - 9.7e-06 24.5 6.1 17 3.9 0.0 8.0 7 1 2 9 9 9 1 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CDF34778.1 - 0.00012 22.4 22.4 1.1 9.9 0.2 7.7 3 2 5 8 8 8 3 PQQ-like domain Ge1_WD40 PF16529.5 CDF34778.1 - 0.0008 18.5 1.2 8.4 5.2 0.0 5.7 1 1 6 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 CDF34778.1 - 0.0029 17.9 0.0 0.0092 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain PQQ PF01011.21 CDF34778.1 - 0.0047 16.8 0.0 14 5.8 0.0 5.5 7 0 0 7 7 7 1 PQQ enzyme repeat WD40_like PF17005.5 CDF34778.1 - 0.0061 15.9 0.0 6 6.1 0.0 4.3 4 2 2 6 6 6 1 WD40-like domain PQQ_2 PF13360.6 CDF34778.1 - 0.76 9.3 34.2 4 6.9 20.9 3.0 1 1 2 3 3 3 0 PQQ-like domain YjeF_N PF03853.15 CDF34780.1 - 1.4e-22 80.4 0.0 2.2e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus Peptidase_M48_N PF16491.5 CDF34781.1 - 1.7e-43 148.6 7.7 3.2e-43 147.7 7.7 1.4 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CDF34781.1 - 5.6e-38 130.7 0.0 1.2e-37 129.7 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_M56 PF05569.11 CDF34781.1 - 0.23 10.6 2.8 0.95 8.6 1.8 2.1 1 1 1 2 2 2 0 BlaR1 peptidase M56 TEX29 PF15839.5 CDF34781.1 - 1.6 9.4 4.0 0.49 11.0 0.3 2.0 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein Homeodomain PF00046.29 CDF34783.1 - 3.4e-08 33.2 0.1 1.3e-07 31.4 0.2 1.9 2 0 0 2 2 2 1 Homeodomain Transcrip_act PF04949.13 CDF34784.1 - 4.9e-07 29.8 13.1 8.6e-07 29.0 13.1 1.3 1 0 0 1 1 1 1 Transcriptional activator cwf21 PF08312.12 CDF34784.1 - 0.0008 19.5 2.3 0.0008 19.5 2.3 2.7 2 1 0 2 2 2 1 cwf21 domain Spc7 PF08317.11 CDF34784.1 - 0.0016 17.4 10.2 0.0026 16.7 10.2 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Golgin_A5 PF09787.9 CDF34784.1 - 0.003 17.1 8.6 0.003 17.1 8.6 1.4 2 0 0 2 2 2 1 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 CDF34784.1 - 0.008 15.8 4.3 0.0095 15.5 4.3 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF1664 PF07889.12 CDF34784.1 - 0.0093 16.0 1.9 0.015 15.3 1.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) AAA_13 PF13166.6 CDF34784.1 - 0.031 13.0 2.7 0.034 12.8 2.7 1.1 1 0 0 1 1 1 0 AAA domain FUSC PF04632.12 CDF34784.1 - 0.033 12.7 2.6 0.04 12.5 2.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DLP_helical PF18709.1 CDF34784.1 - 0.061 12.5 3.1 0.089 12.0 3.1 1.3 1 0 0 1 1 1 0 Dynamin-like helical domain DUF244 PF03112.14 CDF34784.1 - 0.19 11.5 1.3 0.83 9.5 1.2 1.9 1 1 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF DUF3450 PF11932.8 CDF34784.1 - 0.22 10.8 6.9 0.42 9.9 6.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Rootletin PF15035.6 CDF34784.1 - 0.36 10.8 13.1 0.66 10.0 13.1 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion TMPIT PF07851.13 CDF34784.1 - 0.56 9.4 1.6 0.72 9.0 1.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein HIP1_clath_bdg PF16515.5 CDF34784.1 - 0.6 10.8 16.7 0.051 14.2 7.2 2.8 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Atg14 PF10186.9 CDF34784.1 - 0.71 8.9 11.0 1.7 7.6 11.0 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Oxysterol_BP PF01237.18 CDF34784.1 - 0.9 8.3 3.6 1.2 7.9 3.6 1.3 1 1 0 1 1 1 0 Oxysterol-binding protein Fmp27_WPPW PF10359.9 CDF34784.1 - 1.4 7.7 5.2 1.8 7.3 5.2 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain YabA PF06156.13 CDF34784.1 - 1.4 9.6 4.5 3.9 8.2 4.5 1.8 1 1 0 1 1 1 0 Initiation control protein YabA GAS PF13851.6 CDF34784.1 - 2.4 7.4 17.7 0.061 12.7 11.4 1.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Cluap1 PF10234.9 CDF34784.1 - 3.5 7.0 15.1 1.2 8.4 1.9 2.4 1 1 1 2 2 2 0 Clusterin-associated protein-1 Fez1 PF06818.15 CDF34784.1 - 3.6 8.0 13.8 0.42 11.0 9.3 1.6 2 0 0 2 2 2 0 Fez1 OmpH PF03938.14 CDF34784.1 - 4.9 7.5 15.5 1.3 9.4 8.8 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Sec2p PF06428.11 CDF34784.1 - 6.3 6.9 13.0 19 5.3 0.3 3.3 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p ATG16 PF08614.11 CDF34784.1 - 6.9 6.8 18.7 19 5.4 18.7 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Sipho_Gp157 PF05565.11 CDF34784.1 - 9.1 6.3 16.2 0.04 13.9 6.2 2.0 2 1 0 2 2 2 0 Siphovirus Gp157 GvpG PF05120.12 CDF34784.1 - 10 6.2 9.3 3 7.9 1.9 2.6 1 1 1 2 2 2 0 Gas vesicle protein G LtrA PF06772.11 CDF34786.1 - 6.7e-20 71.6 8.8 8.4e-20 71.3 8.8 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) rve PF00665.26 CDF34787.1 - 2.1e-07 31.1 0.0 7.3e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain CAF1C_H4-bd PF12265.8 CDF34789.1 - 8.5e-27 93.2 0.2 2.1e-26 91.9 0.1 1.8 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDF34789.1 - 2.1e-26 91.7 8.4 2.5e-07 31.2 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.11 CDF34789.1 - 9.9e-05 22.3 0.4 0.0012 18.8 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 CDF34789.1 - 0.0011 19.2 0.5 0.31 11.4 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytomega_UL20A PF05984.12 CDF34789.1 - 0.35 11.2 1.6 1.7 9.0 0.0 2.6 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein TP_methylase PF00590.20 CDF34791.1 - 2.2e-24 86.6 1.5 3.5e-24 85.9 1.5 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Pkr1 PF08636.10 CDF34792.1 - 1.4e-07 31.5 1.2 2.4e-07 30.8 1.2 1.3 1 0 0 1 1 1 1 ER protein Pkr1 Pkinase PF00069.25 CDF34795.1 - 2.6e-79 266.3 0.0 2.9e-79 266.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34795.1 - 1.3e-32 113.1 0.0 1.7e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF34795.1 - 2.1e-05 24.0 0.0 0.00016 21.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDF34795.1 - 3.4e-05 23.0 0.0 9.5e-05 21.5 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF34795.1 - 0.00091 19.2 0.1 0.0013 18.7 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CDF34795.1 - 0.0059 15.7 0.0 0.0094 15.0 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 CDF34795.1 - 0.0063 15.9 0.1 0.015 14.7 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Abhydrolase_1 PF00561.20 CDF34796.1 - 4.3e-25 88.8 0.0 6.2e-18 65.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF34796.1 - 3e-15 57.4 0.0 4.4e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF34796.1 - 5.6e-11 42.2 0.0 7.9e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 CDF34796.1 - 1.6e-05 24.7 0.0 2.3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 CDF34796.1 - 8.3e-05 22.4 0.0 0.00027 20.7 0.0 1.8 2 0 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 CDF34796.1 - 0.00016 21.9 0.0 0.0003 21.0 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.7 CDF34796.1 - 0.0003 19.8 0.0 0.0027 16.6 0.0 2.0 2 0 0 2 2 2 1 Chlorophyllase enzyme Ndr PF03096.14 CDF34796.1 - 0.00065 18.5 0.0 0.0023 16.7 0.0 1.7 1 1 0 1 1 1 1 Ndr family Chlorophyllase PF07224.11 CDF34796.1 - 0.0061 15.6 0.0 0.033 13.2 0.0 1.9 2 0 0 2 2 2 1 Chlorophyllase Ser_hydrolase PF06821.13 CDF34796.1 - 0.029 14.2 0.2 0.1 12.4 0.2 1.9 1 1 1 2 2 2 0 Serine hydrolase Abhydrolase_5 PF12695.7 CDF34796.1 - 0.047 13.4 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Acyl_transf_1 PF00698.21 CDF34796.1 - 0.072 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Acyl transferase domain Lipase_3 PF01764.25 CDF34796.1 - 0.098 12.5 0.1 0.27 11.1 0.1 1.7 1 1 0 1 1 1 0 Lipase (class 3) DUF3141 PF11339.8 CDF34796.1 - 0.11 10.9 0.0 0.16 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) DUF676 PF05057.14 CDF34796.1 - 0.14 11.7 0.0 0.29 10.6 0.0 1.5 1 1 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 CDF34796.1 - 0.17 11.0 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase GHMP_kinases_N PF00288.26 CDF34797.1 - 4.9e-05 23.5 0.1 0.00011 22.3 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain APS_kinase PF01583.20 CDF34797.1 - 0.013 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Kinesin PF00225.23 CDF34798.1 - 1.4e-84 283.9 0.0 2.2e-84 283.2 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDF34798.1 - 7.7e-08 32.4 0.0 1.6e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding SAM_2 PF07647.17 CDF34798.1 - 1.6e-07 31.3 0.0 7.4e-06 26.0 0.0 2.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CDF34798.1 - 1.4e-06 28.7 0.0 6.8e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Methyltransf_10 PF05971.12 CDF34799.1 - 1.7e-42 145.8 0.0 1.5e-28 100.1 0.0 2.1 1 1 1 2 2 2 2 RNA methyltransferase PrmA PF06325.13 CDF34799.1 - 1.6e-06 27.7 0.0 2.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CDF34799.1 - 0.00014 21.7 0.0 0.00031 20.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF34799.1 - 0.00023 21.8 0.0 0.0015 19.2 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 CDF34799.1 - 0.00042 19.9 0.0 0.00071 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 CDF34799.1 - 0.011 16.5 0.0 0.048 14.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain MCC-bdg_PDZ PF10506.9 CDF34800.1 - 0.031 14.3 0.3 0.098 12.7 0.1 1.9 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF5522 PF17653.1 CDF34801.1 - 1.2e-13 50.8 8.1 2e-11 43.7 0.2 2.5 2 0 0 2 2 2 2 Family of unknown function (DUF5522) EXOSC1 PF10447.9 CDF34803.1 - 2.8e-15 56.9 1.8 4.1e-09 37.0 0.1 2.3 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 CDF34803.1 - 7.3e-10 38.5 0.2 1.3e-09 37.7 0.2 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region S1 PF00575.23 CDF34803.1 - 0.027 14.8 0.0 0.12 12.8 0.0 2.1 2 0 0 2 2 2 0 S1 RNA binding domain TRAM PF01938.20 CDF34803.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 TRAM domain Helicase_C PF00271.31 CDF34804.1 - 1.9e-09 37.9 0.0 3.2e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CDF34804.1 - 1.8e-08 34.0 11.2 3.7e-08 33.1 11.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF34804.1 - 1.1e-07 31.6 10.2 2e-07 30.8 10.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF34804.1 - 2.6e-07 30.9 11.3 4.8e-07 30.0 11.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF34804.1 - 5.1e-07 29.5 9.9 9.6e-07 28.6 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF34804.1 - 3.4e-05 23.8 5.1 3.4e-05 23.8 5.1 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 CDF34804.1 - 0.00038 20.2 10.6 0.00079 19.2 10.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 CDF34804.1 - 0.0011 18.8 11.2 0.0033 17.3 11.3 1.8 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF34804.1 - 0.027 14.3 12.2 0.086 12.7 6.3 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDF34804.1 - 0.041 14.1 10.1 0.09 12.9 10.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 CDF34804.1 - 0.062 13.1 5.7 0.16 11.8 5.7 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.14 CDF34804.1 - 0.077 12.8 1.0 4 7.4 0.2 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_10 PF16685.5 CDF34804.1 - 0.082 13.1 7.1 0.2 11.8 7.1 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 CDF34804.1 - 0.93 9.4 8.7 0.66 9.9 6.5 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein WD40 PF00400.32 CDF34806.1 - 7e-24 83.7 12.4 5.6e-06 27.0 0.4 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF34806.1 - 3.8e-05 23.9 4.1 0.048 14.0 0.2 3.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Adhesin_Dr PF04619.12 CDF34806.1 - 0.039 13.9 0.1 0.075 13.0 0.1 1.7 1 0 0 1 1 1 0 Dr-family adhesin Nup160 PF11715.8 CDF34806.1 - 1.2 7.7 8.3 18 3.8 0.1 3.8 2 1 2 4 4 4 0 Nucleoporin Nup120/160 WD40 PF00400.32 CDF34807.1 - 9.3e-20 70.6 19.3 7.5e-06 26.6 0.5 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat TIR_2 PF13676.6 CDF34807.1 - 4.2e-17 62.8 0.0 1.7e-15 57.7 0.0 3.3 4 0 0 4 4 4 1 TIR domain NB-ARC PF00931.22 CDF34807.1 - 5.5e-16 58.5 0.0 1.3e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF34807.1 - 6.2e-08 32.6 0.0 1.3e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 TIR domain AAA_22 PF13401.6 CDF34807.1 - 0.00031 21.0 0.0 0.00077 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain ANAPC4_WD40 PF12894.7 CDF34807.1 - 0.0014 18.9 3.5 16 5.8 0.0 4.0 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain TIR-like PF10137.9 CDF34807.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Nup160 PF11715.8 CDF34807.1 - 0.31 9.6 1.5 6.9 5.2 0.0 3.2 4 0 0 4 4 4 0 Nucleoporin Nup120/160 Radial_spoke_3 PF06098.11 CDF34809.1 - 0.024 13.9 0.2 0.027 13.8 0.2 1.0 1 0 0 1 1 1 0 Radial spoke protein 3 Y_phosphatase2 PF03162.13 CDF34809.1 - 0.079 12.5 0.0 0.086 12.4 0.0 1.0 1 0 0 1 1 1 0 Tyrosine phosphatase family WD40 PF00400.32 CDF34811.1 - 3.3e-58 192.3 61.9 4.5e-06 27.3 0.3 11.6 11 0 0 11 11 11 10 WD domain, G-beta repeat NB-ARC PF00931.22 CDF34811.1 - 1.9e-16 60.0 0.0 4.7e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain TIR_2 PF13676.6 CDF34811.1 - 5.7e-16 59.2 0.0 2.4e-15 57.2 0.0 2.1 2 0 0 2 2 2 1 TIR domain ANAPC4_WD40 PF12894.7 CDF34811.1 - 3e-08 33.9 17.1 1.8 9.0 0.1 8.6 1 1 10 11 11 11 3 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.20 CDF34811.1 - 8.8e-08 32.1 0.0 1.9e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain Nup160 PF11715.8 CDF34811.1 - 6.8e-05 21.7 20.3 3.3 6.2 0.0 9.2 6 3 3 10 10 10 3 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF34811.1 - 0.0025 18.1 0.0 0.0063 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain APAF1_C PF17908.1 CDF34811.1 - 0.097 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain TIR-like PF10137.9 CDF34811.1 - 0.15 12.0 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain PDCD2_C PF04194.13 CDF34812.1 - 2.5e-29 102.6 0.3 6.5e-27 94.7 0.2 2.4 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain EMP24_GP25L PF01105.24 CDF34813.1 - 1.1e-43 149.3 0.5 1.3e-43 149.1 0.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD BspA_v PF18220.1 CDF34813.1 - 0.089 12.9 0.1 15 5.7 0.0 2.5 1 1 2 3 3 3 0 Adhesin BspA variable domain XPG_I PF00867.18 CDF34814.1 - 1e-23 83.5 0.1 1.9e-23 82.6 0.1 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CDF34814.1 - 9.6e-23 80.6 0.0 2e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CDF34814.1 - 4.4e-06 26.4 0.0 7.5e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 CDF34814.1 - 0.069 13.8 0.0 0.15 12.7 0.0 1.5 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold ArfGap PF01412.18 CDF34815.1 - 4.1e-21 75.2 0.0 4.1e-21 75.2 0.0 2.7 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf Macoilin PF09726.9 CDF34815.1 - 0.06 11.9 16.6 0.091 11.3 16.6 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 CDF34815.1 - 1.1 6.2 11.6 1.5 5.9 11.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 CDF34815.1 - 1.5 9.3 6.7 3.5 8.2 6.7 1.6 1 0 0 1 1 1 0 Sine oculis-binding protein Gln-synt_C PF00120.24 CDF34816.1 - 1e-65 222.1 0.0 1.3e-65 221.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Ribosomal_L13 PF00572.18 CDF34817.1 - 5.6e-10 39.5 0.1 4.2e-08 33.5 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 TGT PF01702.18 CDF34820.1 - 4.2e-16 59.1 0.0 5.4e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Corona_NS1 PF06145.11 CDF34820.1 - 1.4 8.5 7.2 6.7 6.3 1.7 2.3 2 0 0 2 2 2 0 Coronavirus nonstructural protein NS1 DUF3429 PF11911.8 CDF34821.1 - 1e-30 106.9 13.3 1.5e-30 106.4 13.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) OHCU_decarbox PF09349.10 CDF34822.1 - 4.8e-34 118.1 1.6 5.6e-34 117.9 1.6 1.0 1 0 0 1 1 1 1 OHCU decarboxylase AAA_16 PF13191.6 CDF34822.1 - 0.031 14.7 2.5 0.048 14.0 2.5 1.5 1 1 0 1 1 1 0 AAA ATPase domain Reprolysin PF01421.19 CDF34822.1 - 0.061 13.2 0.1 0.082 12.8 0.1 1.1 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease NUC153 PF08159.12 CDF34825.1 - 3.5e-08 33.1 0.8 3.5e-08 33.1 0.8 3.6 3 0 0 3 3 3 1 NUC153 domain CKS PF01111.19 CDF34828.1 - 3.2e-35 120.2 1.1 3.7e-35 120.0 1.1 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit CDC45 PF02724.14 CDF34829.1 - 2e-131 439.4 9.6 2e-130 436.1 9.6 2.3 1 1 0 1 1 1 1 CDC45-like protein CCDC106 PF15794.5 CDF34829.1 - 0.47 10.1 10.0 0.36 10.5 3.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SPT6_acidic PF14632.6 CDF34829.1 - 2.7 8.7 30.7 3.4 8.3 9.6 2.4 1 1 1 2 2 2 0 Acidic N-terminal SPT6 Rrp15p PF07890.12 CDF34830.1 - 4.4e-10 40.0 16.4 1.4e-09 38.4 16.4 1.9 1 1 0 1 1 1 1 Rrp15p GET2 PF08690.10 CDF34830.1 - 0.017 14.8 5.9 0.037 13.7 5.9 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 PET117 PF15786.5 CDF34830.1 - 0.13 12.5 1.0 7.5 6.9 0.1 2.5 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial Clat_adaptor_s PF01217.20 CDF34832.1 - 1.3e-05 25.2 0.0 5.8e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain DUF2470 PF10615.9 CDF34834.1 - 4.7e-08 33.5 0.0 6.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) AAA PF00004.29 CDF34835.1 - 3.4e-31 108.4 0.0 4.6e-30 104.8 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF34835.1 - 1.9e-11 43.5 0.1 4.5e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDF34835.1 - 1.7e-07 31.7 1.6 4.9e-06 27.0 0.1 3.5 2 2 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 CDF34835.1 - 0.00074 19.6 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDF34835.1 - 0.0016 18.4 0.0 0.009 16.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF34835.1 - 0.0033 17.7 0.0 0.072 13.4 0.0 2.9 2 1 1 3 3 3 1 AAA domain TIP49 PF06068.13 CDF34835.1 - 0.0041 16.4 0.0 0.0088 15.3 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain ATPase_2 PF01637.18 CDF34835.1 - 0.012 15.6 0.0 0.25 11.2 0.0 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 CDF34835.1 - 0.012 15.7 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDF34835.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AFG1_ATPase PF03969.16 CDF34835.1 - 0.11 11.4 0.0 0.51 9.2 0.0 1.9 2 0 0 2 2 2 0 AFG1-like ATPase AAA_7 PF12775.7 CDF34835.1 - 0.13 11.7 0.0 0.65 9.5 0.0 2.0 3 0 0 3 3 3 0 P-loop containing dynein motor region NACHT PF05729.12 CDF34835.1 - 0.15 12.0 0.1 2.5 8.0 0.0 2.6 2 1 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 CDF34835.1 - 0.19 12.1 0.0 0.5 10.8 0.0 1.7 2 0 0 2 2 1 0 RNA helicase ABC1 PF03109.16 CDF34836.1 - 1.1e-24 86.9 0.1 2.1e-24 85.9 0.1 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CDF34836.1 - 0.0031 17.5 0.3 0.69 9.8 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family HSP90 PF00183.18 CDF34838.1 - 1e-72 245.7 6.3 1.3e-72 245.4 6.3 1.2 1 0 0 1 1 1 1 Hsp90 protein Phosphonate-bd PF12974.7 CDF34838.1 - 0.037 13.6 0.0 4 6.9 0.0 2.3 1 1 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein ESM4 PF15952.5 CDF34838.1 - 0.14 12.6 0.3 0.14 12.6 0.3 1.7 2 0 0 2 2 2 0 Enhancer of split M4 family p450 PF00067.22 CDF34839.1 - 1.3e-64 218.7 0.0 1.6e-64 218.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4519 PF15012.6 CDF34839.1 - 0.46 10.7 1.8 11 6.2 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) ADH_zinc_N PF00107.26 CDF34840.1 - 5.1e-18 65.3 0.2 1e-17 64.3 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDF34840.1 - 6.9e-18 64.5 0.3 1.1e-17 63.8 0.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 CDF34840.1 - 0.0025 17.2 0.1 0.0046 16.3 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 CDF34840.1 - 0.0035 18.4 0.0 0.0075 17.3 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CDF34840.1 - 0.018 14.4 0.2 0.032 13.5 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Melibiase PF02065.18 CDF34841.1 - 1.7e-143 477.8 0.0 2.6e-143 477.2 0.0 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 CDF34841.1 - 1.3e-65 221.5 0.0 2.8e-64 217.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 CDF34841.1 - 9.5e-16 58.1 0.0 2.3e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain DUF1752 PF08550.10 CDF34841.1 - 5.5e-09 35.7 1.1 1.2e-08 34.7 1.1 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Melibiase_2 PF16499.5 CDF34841.1 - 0.02 14.1 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Alpha galactosidase A SAPS PF04499.15 CDF34842.1 - 1.4e-12 47.2 0.1 5.2e-12 45.3 0.0 1.9 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein Importin_rep_4 PF18808.1 CDF34842.1 - 0.5 10.7 0.0 0.5 10.7 0.0 2.3 2 1 0 2 2 2 0 Importin repeat BRCA-2_OB1 PF09103.10 CDF34843.1 - 8e-19 67.8 0.0 1.6e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Glycolytic PF00274.19 CDF34844.1 - 1.6e-141 471.1 0.0 1.9e-141 470.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I DUF5107 PF17128.4 CDF34844.1 - 0.051 12.7 0.0 0.079 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5107) Redoxin PF08534.10 CDF34846.1 - 5.7e-22 78.0 0.1 7e-22 77.7 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDF34846.1 - 4.3e-07 29.9 0.0 5.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family AAA PF00004.29 CDF34848.1 - 1.2e-26 93.6 0.1 4.9e-18 65.8 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF34848.1 - 5.4e-07 30.2 3.5 0.0099 16.3 0.1 3.8 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CDF34848.1 - 2.4e-06 27.9 1.1 0.031 14.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CDF34848.1 - 1.6e-05 24.7 0.0 0.08 12.7 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 CDF34848.1 - 3.7e-05 24.0 0.1 0.019 15.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 CDF34848.1 - 7.2e-05 22.6 0.0 0.02 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CDF34848.1 - 0.00038 20.0 0.1 0.05 13.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 CDF34848.1 - 0.0004 20.5 0.0 0.34 11.0 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 CDF34848.1 - 0.00046 19.9 0.5 0.2 11.4 0.0 3.2 3 1 0 3 3 3 1 Sigma-54 interaction domain PhoH PF02562.16 CDF34848.1 - 0.00048 19.7 0.0 1.1 8.7 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_33 PF13671.6 CDF34848.1 - 0.00054 20.1 0.1 0.17 12.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain Zot PF05707.12 CDF34848.1 - 0.00064 19.4 0.2 0.036 13.7 0.0 2.8 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) AAA_5 PF07728.14 CDF34848.1 - 0.0013 18.7 0.3 0.5 10.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CDF34848.1 - 0.0017 18.4 0.0 0.052 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDF34848.1 - 0.002 17.7 0.6 0.48 10.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDF34848.1 - 0.0024 17.2 0.1 1.2 8.3 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain RsgA_GTPase PF03193.16 CDF34848.1 - 0.0027 17.6 0.1 0.08 12.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase Torsin PF06309.11 CDF34848.1 - 0.0031 17.6 0.1 0.014 15.5 0.1 2.1 2 0 0 2 2 1 1 Torsin ABC_tran PF00005.27 CDF34848.1 - 0.0054 17.3 0.1 3.9 8.0 0.0 3.0 2 0 0 2 2 2 1 ABC transporter ATPase PF06745.13 CDF34848.1 - 0.0054 16.1 0.2 0.95 8.8 0.0 2.4 2 0 0 2 2 2 1 KaiC AAA_23 PF13476.6 CDF34848.1 - 0.0056 17.2 0.1 4.1 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF34848.1 - 0.0061 16.5 0.8 0.23 11.4 0.1 2.8 2 1 0 2 2 2 1 NACHT domain AAA_2 PF07724.14 CDF34848.1 - 0.0067 16.6 0.0 0.06 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) CbiA PF01656.23 CDF34848.1 - 0.0076 16.3 0.0 0.039 14.0 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 CDF34848.1 - 0.017 15.6 0.4 5 7.7 0.1 3.6 2 1 1 3 3 3 0 AAA domain RuvB_N PF05496.12 CDF34848.1 - 0.018 14.8 0.0 3.5 7.3 0.0 2.9 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain DUF2791 PF10923.8 CDF34848.1 - 0.042 12.7 0.5 0.14 10.9 0.1 2.1 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) PIF1 PF05970.14 CDF34848.1 - 0.051 12.7 0.1 0.11 11.7 0.1 1.4 1 0 0 1 1 1 0 PIF1-like helicase Mg_chelatase PF01078.21 CDF34848.1 - 0.054 12.9 0.0 6.4 6.1 0.0 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 CDF34848.1 - 0.061 13.2 0.1 9.6 6.0 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CDF34848.1 - 0.071 13.1 0.1 0.91 9.5 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP-synt_ab PF00006.25 CDF34848.1 - 0.074 12.7 0.1 0.82 9.3 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Bac_DnaA PF00308.18 CDF34848.1 - 0.08 12.8 3.8 4.8 7.0 0.7 3.8 3 1 0 3 3 3 0 Bacterial dnaA protein PPV_E1_C PF00519.17 CDF34848.1 - 0.1 11.4 0.3 3.3 6.5 0.1 2.1 2 0 0 2 2 2 0 Papillomavirus helicase APS_kinase PF01583.20 CDF34848.1 - 0.15 11.9 0.5 0.52 10.2 0.1 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase Rad17 PF03215.15 CDF34848.1 - 0.18 11.7 0.0 0.6 10.0 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain Pns11_12 PF17464.2 CDF34848.1 - 6.6 6.4 9.0 0.54 9.9 3.7 1.8 3 0 0 3 3 1 0 Non-structural protein 11 and 12 DNA_pol_E_B PF04042.16 CDF34849.1 - 1e-23 83.8 0.1 1.3e-23 83.4 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CDF34849.1 - 0.1 12.7 0.2 0.51 10.5 0.2 2.1 2 1 0 2 2 2 0 DNA polymerase delta subunit OB-fold domain NUDIX_4 PF14815.6 CDF34850.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 NUDIX domain HECT PF00632.25 CDF34855.1 - 5.7e-90 301.9 0.0 7.9e-90 301.5 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4982 PF16355.5 CDF34855.1 - 0.11 12.4 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4982) PhoLip_ATPase_C PF16212.5 CDF34860.1 - 2.9e-59 200.9 21.3 2.9e-59 200.9 21.3 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDF34860.1 - 8.6e-22 76.6 2.3 8.6e-22 76.6 2.3 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDF34860.1 - 4.6e-12 46.7 1.7 5.4e-07 30.1 0.5 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF34860.1 - 1.2e-10 41.3 0.0 3.5e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDF34860.1 - 7.7e-08 32.1 0.1 7.7e-08 32.1 0.1 2.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDF34860.1 - 0.00021 21.1 0.0 0.0058 16.4 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF34860.1 - 0.041 14.3 0.0 1.3 9.4 0.0 2.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Retrotran_gag_2 PF14223.6 CDF34864.1 - 3.7e-33 114.1 0.4 6.9e-33 113.2 0.4 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF34864.1 - 2.6e-22 79.2 0.0 8.8e-22 77.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF34864.1 - 3.9e-07 29.8 0.0 1.4e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF34864.1 - 0.00064 19.4 0.0 0.0019 17.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_6 PF15288.6 CDF34864.1 - 0.077 12.8 2.8 0.24 11.3 2.8 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF34864.1 - 0.17 11.6 2.5 1.9 8.3 2.2 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 CDF34864.1 - 0.51 10.5 3.9 1.2 9.4 3.9 1.6 1 0 0 1 1 1 0 Zinc knuckle Helicase_C PF00271.31 CDF34865.1 - 1.1e-25 90.1 0.0 2.1e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF34865.1 - 3.5e-09 36.7 0.2 6.1e-09 35.9 0.1 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase adh_short PF00106.25 CDF34871.1 - 2e-12 47.0 0.0 2.7e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDF34871.1 - 6e-12 45.8 0.0 9.6e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CDF34871.1 - 3.7e-08 33.2 0.0 9.6e-08 31.9 0.1 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 CDF34871.1 - 0.0085 15.8 0.2 0.016 15.0 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N PF00107.26 CDF34871.1 - 0.047 13.7 0.2 0.069 13.1 0.2 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Na_Ca_ex PF01699.24 CDF34872.1 - 8.6e-38 129.7 29.8 5.1e-19 68.7 6.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Peptidase_C48 PF02902.19 CDF34876.1 - 1.1e-21 77.7 0.0 3.2e-21 76.2 0.0 1.6 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Transketolase_C PF02780.20 CDF34877.1 - 3.7e-20 72.0 0.0 4.8e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CDF34878.1 - 1.2e-33 116.3 0.0 1.5e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CDF34878.1 - 6.2e-15 55.1 1.9 6.6e-12 45.2 0.0 3.4 3 1 1 4 4 4 2 1-deoxy-D-xylulose-5-phosphate synthase Enolase_C PF00113.22 CDF34880.1 - 7.8e-147 488.2 0.0 1e-146 487.9 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CDF34880.1 - 7.7e-59 197.6 0.2 1.4e-58 196.7 0.2 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CDF34880.1 - 3.7e-07 29.9 0.0 6.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDF34880.1 - 0.0084 15.3 0.1 0.016 14.4 0.1 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Dna2 PF08696.11 CDF34880.1 - 0.099 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 DNA replication factor Dna2 IGPS PF00218.21 CDF34882.1 - 3.1e-71 239.5 0.0 4.1e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase YukD PF08817.10 CDF34882.1 - 0.055 14.2 0.0 0.11 13.2 0.0 1.5 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD FMN_dh PF01070.18 CDF34882.1 - 0.23 10.5 1.9 0.62 9.0 1.9 1.7 1 1 0 1 1 1 0 FMN-dependent dehydrogenase DUF99 PF01949.16 CDF34883.1 - 1.9e-37 128.5 0.0 2.7e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF99 Ribosomal_S30AE PF02482.19 CDF34884.1 - 1.2e-21 77.3 1.2 1.7e-21 76.8 1.2 1.2 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein Ribosom_S30AE_C PF16321.5 CDF34884.1 - 2.1e-12 46.5 0.0 5.8e-12 45.1 0.0 1.8 1 1 1 2 2 2 1 Sigma 54 modulation/S30EA ribosomal protein C terminus HSBP1 PF06825.12 CDF34884.1 - 0.067 13.1 0.1 0.2 11.5 0.2 1.7 2 0 0 2 2 2 0 Heat shock factor binding protein 1 VHL PF01847.16 CDF34884.1 - 0.16 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 VHL beta domain Nkap_C PF06047.11 CDF34885.1 - 1.3e-44 150.5 1.0 1.3e-44 150.5 1.0 2.9 2 1 1 3 3 3 1 NF-kappa-B-activating protein C-terminal domain NINJA_B PF16136.5 CDF34885.1 - 4.5 7.7 13.1 21 5.5 7.3 2.4 2 0 0 2 2 2 0 Putative nuclear localisation signal DIM1 PF02966.16 CDF34886.1 - 1.6e-57 192.9 0.2 1.8e-57 192.8 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CDF34886.1 - 0.03 14.3 0.1 0.041 13.9 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin ThiF PF00899.21 CDF34887.1 - 6.1e-15 55.2 0.0 9.5e-08 31.7 0.0 2.1 2 0 0 2 2 2 2 ThiF family Ribosomal_L17 PF01196.19 CDF34889.1 - 5.9e-34 116.8 0.0 8.5e-34 116.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 HTH_ParB PF17762.1 CDF34889.1 - 0.16 11.8 3.5 2.6 7.9 0.2 2.3 1 1 1 2 2 2 0 HTH domain found in ParB protein T6SS_VasE PF05936.12 CDF34892.1 - 0.085 11.5 0.4 0.13 10.9 0.4 1.2 1 0 0 1 1 1 0 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE Thioredoxin PF00085.20 CDF34893.1 - 5.2e-33 113.1 0.0 1.4e-25 89.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 CDF34893.1 - 9.1e-11 42.0 0.0 0.011 15.6 0.0 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDF34893.1 - 1.8e-05 25.1 0.0 0.045 14.2 0.1 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CDF34893.1 - 0.00032 20.1 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 CDF34893.1 - 0.0016 18.7 0.0 2.6 8.4 0.0 3.2 2 1 1 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 CDF34893.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_3 PF13192.6 CDF34893.1 - 0.021 14.8 0.0 0.41 10.7 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin domain HyaE PF07449.11 CDF34893.1 - 0.024 14.6 0.0 4.3 7.4 0.0 2.5 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 CDF34893.1 - 0.037 13.8 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Redoxin PF08534.10 CDF34893.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Redoxin SET PF00856.28 CDF34895.1 - 5.2e-13 49.7 0.0 3.1e-12 47.2 0.0 2.5 1 1 0 1 1 1 1 SET domain zf-4CXXC_R1 PF10497.9 CDF34895.1 - 0.00047 20.3 8.3 0.0017 18.5 8.3 2.0 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 BRK PF07533.16 CDF34895.1 - 0.015 14.9 0.0 0.46 10.1 0.0 2.9 3 0 0 3 3 3 0 BRK domain AMPK1_CBM PF16561.5 CDF34895.1 - 0.021 15.0 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase CTP_transf_like PF01467.26 CDF34897.1 - 6.8e-41 139.8 0.4 1.5e-22 80.3 0.0 2.3 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 CDF34897.1 - 2.8e-07 30.6 0.9 0.00043 20.2 0.1 3.0 2 1 0 2 2 2 2 FAD synthetase Pantoate_ligase PF02569.15 CDF34897.1 - 0.023 13.9 0.0 1.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase Colicin_Pyocin PF01320.18 CDF34897.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein Prenyltrans PF00432.21 CDF34899.1 - 5.7e-35 118.7 18.3 5.3e-09 35.7 0.3 5.6 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat DUF3684 PF12449.8 CDF34901.1 - 1.6e-127 427.0 0.0 3e-91 306.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 CDF34901.1 - 0.0084 15.9 0.0 0.021 14.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WLM PF08325.10 CDF34901.1 - 0.12 12.5 0.7 0.29 11.2 0.7 1.6 1 0 0 1 1 1 0 WLM domain RNase_H PF00075.24 CDF34916.1 - 1.9e-09 37.9 0.0 4.5e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CDF34916.1 - 0.0014 19.0 0.8 0.0014 19.0 0.8 6.3 7 1 0 7 7 7 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF34916.1 - 0.039 14.8 0.4 0.039 14.8 0.4 6.4 6 0 0 6 6 6 0 C2H2-type zinc finger zf-MYST PF17772.1 CDF34916.1 - 0.11 12.1 9.8 0.16 11.6 0.3 3.4 2 1 1 3 3 3 0 MYST family zinc finger domain DUF2256 PF10013.9 CDF34916.1 - 0.16 12.1 5.6 4.7 7.4 0.2 3.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-FCS PF06467.14 CDF34916.1 - 0.28 11.1 6.0 2.8 8.0 0.3 3.1 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_2 PF12756.7 CDF34916.1 - 4.4 7.7 16.7 0.042 14.2 4.8 2.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Sel1 PF08238.12 CDF34918.1 - 1.9e-62 206.3 13.4 1.4e-06 28.8 0.1 10.3 10 0 0 10 10 10 9 Sel1 repeat TPR_6 PF13174.6 CDF34918.1 - 1.4e-09 38.0 8.0 0.6 10.9 0.0 8.0 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDF34918.1 - 0.13 12.3 6.7 1.2 9.3 0.1 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF34918.1 - 0.49 10.9 9.3 77 3.9 0.1 6.3 7 1 1 8 8 8 0 Tetratricopeptide repeat RNB PF00773.19 CDF34919.1 - 2.7e-27 96.0 0.1 6e-23 81.7 0.0 2.2 1 1 1 2 2 2 2 RNB domain Helicase_C PF00271.31 CDF34921.1 - 1.1e-14 54.7 0.0 2.6e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF34921.1 - 1.3e-09 38.1 0.0 3.7e-09 36.6 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 CDF34921.1 - 3.1e-06 27.6 0.2 1.9e-05 25.0 0.2 2.5 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 CDF34921.1 - 0.0073 16.3 0.0 0.024 14.6 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ABC_tran PF00005.27 CDF34924.1 - 1.2e-35 123.0 0.0 1.7e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDF34924.1 - 4.1e-06 26.4 0.5 0.00015 21.3 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 CDF34924.1 - 3.5e-05 23.6 0.1 4.9e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_22 PF13401.6 CDF34924.1 - 0.00022 21.5 0.1 0.0013 19.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDF34924.1 - 0.0007 18.9 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDF34924.1 - 0.0035 17.8 0.7 0.01 16.2 0.7 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF34924.1 - 0.011 15.5 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 CDF34924.1 - 0.012 15.6 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_ATPase PF09818.9 CDF34924.1 - 0.018 13.8 0.1 0.03 13.1 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_15 PF13175.6 CDF34924.1 - 0.02 14.6 0.0 0.024 14.4 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 CDF34924.1 - 0.023 14.9 0.6 0.28 11.4 0.6 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 CDF34924.1 - 0.025 14.5 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 CDF34924.1 - 0.026 14.5 0.0 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CDF34924.1 - 0.028 14.7 0.4 0.1 12.9 0.4 2.0 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 CDF34924.1 - 0.031 13.4 0.0 0.041 13.1 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 CDF34924.1 - 0.037 13.8 0.2 1.3 8.8 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDF34924.1 - 0.038 13.7 2.3 0.34 10.6 2.3 2.0 1 1 0 1 1 1 0 AAA domain p450 PF00067.22 CDF34928.1 - 2.1e-66 224.6 0.0 2.8e-66 224.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Metal_resist PF13801.6 CDF34930.1 - 0.33 11.2 5.1 0.29 11.3 3.9 1.6 1 1 0 1 1 1 0 Heavy-metal resistance M20_dimer PF07687.14 CDF34932.1 - 5.4e-11 42.4 0.1 9.6e-11 41.6 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CDF34932.1 - 5.6e-09 36.0 0.1 7.4e-09 35.6 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DDE_3 PF13358.6 CDF34933.1 - 2.3e-19 69.6 0.0 3.7e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF34933.1 - 9.5e-07 28.6 0.0 1.8e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF34933.1 - 0.00018 21.2 0.2 0.00079 19.1 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF34933.1 - 0.0046 17.5 0.9 0.012 16.2 0.4 2.1 2 1 0 2 2 2 1 Homeodomain-like domain PIF1 PF05970.14 CDF34934.1 - 3.1e-85 286.5 0.0 1e-62 212.5 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF34934.1 - 4e-56 190.2 0.0 7.3e-56 189.4 0.0 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF34934.1 - 1.9e-12 47.3 0.0 3.6e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF34934.1 - 0.076 10.9 0.0 0.13 10.2 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF34934.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus AAA_19 PF13245.6 CDF34934.1 - 0.2 12.0 0.0 0.52 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Anoctamin PF04547.12 CDF34935.1 - 2.1e-92 310.3 14.5 2.5e-92 310.1 14.5 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel ELO PF01151.18 CDF34939.1 - 2.8e-61 207.2 19.1 3.4e-61 206.9 19.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Pam17 PF08566.10 CDF34939.1 - 0.011 15.6 1.0 0.068 13.0 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 Vps52 PF04129.12 CDF34940.1 - 6.1e-78 262.8 0.0 7.3e-78 262.5 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 CDF34940.1 - 1.4e-05 23.7 0.5 0.29 9.5 0.0 3.7 2 1 1 3 3 3 2 Exocyst complex component Sec3 GAS PF13851.6 CDF34940.1 - 0.077 12.3 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 CDF34940.1 - 0.082 13.0 0.6 0.19 11.8 0.6 1.5 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Exo70 PF03081.15 CDF34940.1 - 0.11 11.5 0.4 16 4.4 0.0 2.6 1 1 0 2 2 2 0 Exo70 exocyst complex subunit PilJ PF13675.6 CDF34940.1 - 0.98 9.5 6.4 3.1 7.8 0.0 3.5 3 1 1 4 4 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF563 PF04577.14 CDF34943.1 - 2.3e-08 34.4 0.0 4.6e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Macoilin PF09726.9 CDF34946.1 - 1.2 7.6 14.3 1.5 7.3 14.3 1.1 1 0 0 1 1 1 0 Macoilin family SelP_N PF04592.14 CDF34946.1 - 1.5 8.2 27.0 2.9 7.2 27.0 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SHMT PF00464.19 CDF34947.1 - 3.4e-118 394.7 0.0 4e-118 394.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 CDF34947.1 - 0.016 14.5 0.1 0.029 13.6 0.0 1.4 2 0 0 2 2 2 0 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CDF34947.1 - 0.05 12.8 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Metallophos PF00149.28 CDF34948.1 - 4.6e-09 37.1 0.0 1e-08 36.0 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF34948.1 - 0.00098 19.3 0.0 0.0023 18.1 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SNF2_N PF00176.23 CDF34949.1 - 3.5e-70 236.5 0.0 4.8e-70 236.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF34949.1 - 1.6e-14 54.2 0.0 4.8e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CDF34949.1 - 1.1e-07 31.5 11.2 2.7e-07 30.3 11.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF34949.1 - 6.4e-07 29.1 10.2 1.4e-06 28.0 10.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF34949.1 - 1.5e-06 28.4 11.3 3.6e-06 27.2 11.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF34949.1 - 2.8e-06 27.1 9.9 7e-06 25.8 9.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HIRAN PF08797.11 CDF34949.1 - 4.5e-05 23.3 0.0 0.00016 21.6 0.0 1.9 2 0 0 2 2 1 1 HIRAN domain DEAD PF00270.29 CDF34949.1 - 0.00015 21.6 0.0 0.00048 19.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 CDF34949.1 - 0.0023 17.8 9.9 0.0084 16.1 9.9 2.1 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 CDF34949.1 - 0.0024 17.6 10.6 0.0059 16.4 10.6 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 CDF34949.1 - 0.0033 17.4 10.2 0.009 16.0 10.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.6 CDF34949.1 - 0.3 11.0 5.9 0.79 9.6 5.9 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 CDF34949.1 - 0.42 10.5 5.6 1.5 8.7 5.6 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 CDF34949.1 - 0.62 10.0 11.8 11 5.9 11.7 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 CDF34949.1 - 0.64 10.2 7.4 1.7 8.9 7.4 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Zincin_2 PF10103.9 CDF34950.1 - 0.039 13.2 0.2 0.045 13.0 0.2 1.0 1 0 0 1 1 1 0 Zincin-like metallopeptidase COG6 PF06419.11 CDF34951.1 - 2.7e-132 442.1 0.0 3.1e-132 442.0 0.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DUF455 PF04305.14 CDF34953.1 - 2.2e-73 246.8 0.0 2.6e-73 246.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Gemin6 PF06372.12 CDF34956.1 - 1.5e-05 24.6 0.0 0.0021 17.6 0.0 2.0 2 0 0 2 2 2 2 Gemin6 protein Nucleoside_tran PF01733.18 CDF34957.1 - 5.7e-21 75.2 11.8 9.3e-20 71.2 11.8 2.0 1 1 0 1 1 1 1 Nucleoside transporter Cytochrom_B_C PF00032.17 CDF34957.1 - 6.5 7.1 7.9 15 6.0 0.8 2.9 2 1 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD Pyr_redox_2 PF07992.14 CDF34959.1 - 2.9e-07 30.0 0.0 3.5e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDF34959.1 - 0.00076 19.5 0.0 0.044 13.8 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 CDF34959.1 - 0.005 17.3 0.0 0.0072 16.7 0.0 1.5 1 1 0 1 1 1 1 Putative NAD(P)-binding DAO PF01266.24 CDF34959.1 - 0.12 11.9 0.0 0.82 9.2 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 CDF34959.1 - 0.17 10.9 0.2 14 4.6 0.2 2.0 1 1 1 2 2 2 0 Glucose inhibited division protein A PAP_fibrillin PF04755.12 CDF34960.1 - 0.0001 22.3 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 PAP_fibrillin Rad51 PF08423.11 CDF34961.1 - 2.7e-103 344.7 0.2 3.3e-103 344.4 0.2 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 CDF34961.1 - 3e-13 49.9 0.0 4e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 CDF34961.1 - 1.7e-08 34.3 0.0 2.8e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CDF34961.1 - 7.9e-05 22.1 0.0 0.00014 21.3 0.0 1.5 1 0 0 1 1 1 1 KaiC HHH_5 PF14520.6 CDF34961.1 - 0.0073 16.9 0.1 0.018 15.6 0.1 1.7 1 1 0 1 1 1 1 Helix-hairpin-helix domain PAXNEB PF05625.11 CDF34961.1 - 0.16 11.0 0.0 1.6 7.8 0.0 2.0 2 0 0 2 2 2 0 PAXNEB protein Malic_M PF03949.15 CDF34963.1 - 2.5e-86 289.1 0.2 3.4e-86 288.7 0.2 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CDF34963.1 - 5.3e-67 225.1 0.0 1e-66 224.2 0.0 1.5 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain RT_RNaseH PF17917.1 CDF34964.1 - 1.4e-37 128.1 0.2 2e-34 118.0 0.0 2.8 2 1 0 3 3 3 2 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF34964.1 - 4e-36 123.1 0.0 1.9e-34 117.7 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF34964.1 - 1.8e-17 63.6 0.1 4e-17 62.5 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF34964.1 - 6.4e-11 42.2 0.5 1.3e-10 41.2 0.5 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDF34964.1 - 0.025 14.8 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger rve_3 PF13683.6 CDF34964.1 - 0.17 11.7 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain zf-H2C2_2 PF13465.6 CDF34968.1 - 1.4e-17 63.2 28.8 1.3e-05 25.4 2.3 5.5 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 CDF34968.1 - 1.2e-15 57.0 27.4 0.00018 21.8 4.1 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF34968.1 - 2.2e-13 49.8 25.9 0.0035 18.0 0.2 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDF34968.1 - 2.7e-07 30.4 32.0 0.0035 17.3 0.9 5.5 5 1 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 CDF34968.1 - 4.9e-05 24.0 15.0 0.00049 20.8 6.8 2.4 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 CDF34968.1 - 0.00017 21.8 18.8 1.4 9.3 0.0 4.8 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDF34968.1 - 0.00066 20.0 17.6 0.75 10.3 2.0 4.5 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CDF34968.1 - 0.0013 18.5 16.4 0.039 13.7 0.3 3.9 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-Di19 PF05605.12 CDF34968.1 - 0.0046 17.2 20.2 0.48 10.8 6.3 3.3 2 1 1 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.18 CDF34968.1 - 0.02 15.1 7.3 0.13 12.6 1.0 2.4 2 0 0 2 2 2 0 BolA-like protein zf-H2C2_5 PF13909.6 CDF34968.1 - 0.077 12.8 20.8 0.88 9.4 5.3 3.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain YyzF PF14116.6 CDF34968.1 - 0.34 11.0 6.7 7 6.8 0.1 3.3 3 0 0 3 3 3 0 YyzF-like protein ADK_lid PF05191.14 CDF34968.1 - 0.36 10.9 0.1 0.36 10.9 0.1 3.9 3 1 1 4 4 4 0 Adenylate kinase, active site lid zf-C2H2_8 PF15909.5 CDF34968.1 - 0.5 10.7 15.7 0.48 10.8 7.6 2.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 CDF34968.1 - 0.62 10.9 12.5 62 4.4 12.3 2.4 1 1 0 1 1 1 0 zinc-ribbon family zf-RRPl_C4 PF17026.5 CDF34968.1 - 0.76 9.9 11.8 13 6.0 11.8 2.1 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-MYST PF17772.1 CDF34968.1 - 0.8 9.4 13.1 8.5 6.1 0.6 3.7 3 1 0 3 3 3 0 MYST family zinc finger domain zf-C2H2_2 PF12756.7 CDF34968.1 - 1.7 9.0 24.5 1.3 9.4 1.9 3.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) C1_4 PF07975.12 CDF34968.1 - 3.3 8.0 16.9 3.1 8.1 1.0 3.4 1 1 1 3 3 3 0 TFIIH C1-like domain DUF629 PF04780.12 CDF34968.1 - 3.6 6.0 20.4 0.44 9.0 0.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF629) zf-C2HC_2 PF13913.6 CDF34968.1 - 3.8 7.5 8.9 7.5 6.6 1.4 3.2 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_9 PF16293.5 CDF34968.1 - 4.3 7.2 9.0 27 4.7 0.2 3.9 2 1 2 4 4 4 0 C2H2 type zinc-finger (1 copy) C5HCH PF17982.1 CDF34968.1 - 4.9 7.4 14.3 1.8 8.8 0.1 4.0 2 1 2 4 4 4 0 NSD Cys-His rich domain Mut7-C PF01927.16 CDF34968.1 - 8.3 6.5 9.7 0.68 10.0 2.4 2.2 1 1 0 2 2 2 0 Mut7-C RNAse domain zf-HIT PF04438.16 CDF34968.1 - 9.4 6.2 14.8 41 4.2 0.3 4.1 4 0 0 4 4 4 0 HIT zinc finger HNH PF01844.23 CDF34968.1 - 9.7 6.5 10.8 24 5.2 0.2 3.9 4 0 0 4 4 3 0 HNH endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF34970.1 - 8.7e-09 35.1 0.0 1.7e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_23 PF13384.6 CDF34970.1 - 7.9e-06 25.5 0.3 4.3e-05 23.2 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain HTH_38 PF13936.6 CDF34970.1 - 9.5e-06 25.3 0.0 2.8e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDF34970.1 - 0.0081 16.4 1.8 0.015 15.6 0.7 2.0 1 1 1 2 2 2 1 Transposase CENP-B_N PF04218.13 CDF34970.1 - 0.018 14.7 0.1 0.25 11.0 0.1 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.6 CDF34970.1 - 0.059 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DDE_3 PF13358.6 CDF34970.1 - 0.061 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Sigma70_r4_2 PF08281.12 CDF34970.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_29 PF13551.6 CDF34970.1 - 0.11 12.5 0.3 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix MMR_HSR1 PF01926.23 CDF34973.1 - 2.4e-18 66.3 0.1 6.7e-18 64.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase KH_2 PF07650.17 CDF34973.1 - 1.7e-10 40.6 0.5 3.7e-10 39.5 0.5 1.6 1 0 0 1 1 1 1 KH domain Dynamin_N PF00350.23 CDF34973.1 - 2.5e-08 34.1 0.2 0.00014 21.9 0.2 2.3 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 CDF34973.1 - 1.4e-06 28.3 0.1 0.0067 16.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CDF34973.1 - 2e-05 24.2 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CDF34973.1 - 2.2e-05 23.9 0.0 3.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 CDF34973.1 - 0.0001 21.9 0.1 0.052 13.1 0.1 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CDF34973.1 - 0.00094 18.9 0.0 0.0066 16.2 0.0 2.2 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 CDF34973.1 - 0.0012 18.3 0.3 1.5 8.2 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family SRPRB PF09439.10 CDF34973.1 - 0.0023 17.4 0.0 0.0055 16.2 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit cobW PF02492.19 CDF34973.1 - 0.0047 16.5 0.8 1.2 8.7 0.1 2.3 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDF34973.1 - 0.011 16.0 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF34973.1 - 0.016 15.7 0.2 0.044 14.3 0.2 1.9 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 CDF34973.1 - 0.018 15.2 0.2 0.051 13.7 0.1 1.8 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CDF34973.1 - 0.018 14.8 0.0 0.052 13.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain N6_Mtase PF02384.16 CDF34973.1 - 0.023 14.0 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Roc PF08477.13 CDF34973.1 - 0.11 12.7 0.1 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 CDF34973.1 - 0.14 12.0 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system GAGA PF09237.11 CDF34974.1 - 0.017 14.9 1.6 0.024 14.4 1.6 1.3 1 0 0 1 1 1 0 GAGA factor FGGY_N PF00370.21 CDF34976.1 - 3.9e-12 46.2 0.0 9.7e-12 45.0 0.0 1.6 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CDF34976.1 - 5e-06 26.4 2.1 1.2e-05 25.1 2.1 1.5 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain URO-D PF01208.17 CDF34977.1 - 3.4e-101 338.8 0.0 4e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Pkinase_Tyr PF07714.17 CDF34978.1 - 4.7e-49 167.0 0.0 1.2e-45 155.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDF34978.1 - 4e-39 134.6 0.0 6.4e-36 124.1 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain EF-hand_7 PF13499.6 CDF34978.1 - 5.5e-15 55.6 3.4 2.5e-11 43.8 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDF34978.1 - 5.6e-14 50.8 1.7 1e-05 25.1 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 CDF34978.1 - 5.3e-11 41.2 1.3 0.00015 21.1 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 CDF34978.1 - 2.2e-06 27.4 1.1 0.25 11.2 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair Kdo PF06293.14 CDF34978.1 - 1.7e-05 24.3 0.1 0.00016 21.1 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_5 PF13202.6 CDF34978.1 - 0.00012 21.4 0.1 0.049 13.1 0.0 2.8 2 0 0 2 2 2 1 EF hand APH PF01636.23 CDF34978.1 - 0.0011 19.0 0.0 0.0044 17.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF34978.1 - 0.0013 17.6 0.0 0.0021 16.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF1679 PF07914.11 CDF34978.1 - 0.018 13.9 0.0 0.029 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Haspin_kinase PF12330.8 CDF34978.1 - 0.088 11.7 0.0 0.31 10.0 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain Peroxidase_ext PF11895.8 CDF34978.1 - 0.22 11.4 0.9 0.5 10.3 0.9 1.5 1 0 0 1 1 1 0 Fungal peroxidase extension region PCMT PF01135.19 CDF34979.1 - 1.7e-51 175.0 0.0 2.2e-51 174.6 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CDF34979.1 - 0.00027 21.6 0.0 0.00049 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF34979.1 - 0.0054 16.5 0.0 0.011 15.5 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDF34979.1 - 0.016 15.2 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDF34979.1 - 0.037 14.7 0.0 0.07 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDF34979.1 - 0.048 13.5 0.0 0.12 12.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 CDF34979.1 - 0.049 13.3 0.0 0.069 12.8 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit PrmA PF06325.13 CDF34979.1 - 0.062 12.7 0.1 0.087 12.2 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 CDF34979.1 - 0.068 12.7 0.0 0.095 12.2 0.0 1.1 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 CDF34979.1 - 0.097 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 CDF34979.1 - 0.29 10.4 0.0 0.4 9.9 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase bZIP_2 PF07716.15 CDF34980.1 - 0.00027 20.9 17.9 0.0047 17.0 17.5 2.7 1 1 2 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 CDF34980.1 - 2.2 8.9 12.6 4.1 8.0 12.6 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.21 CDF34980.1 - 7 6.8 21.3 43 4.3 21.4 2.0 1 1 0 1 1 1 0 bZIP transcription factor Nucleotid_trans PF03407.16 CDF34982.1 - 2.4e-18 66.9 0.0 3.8e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase bZIP_1 PF00170.21 CDF34983.1 - 3 8.0 19.8 4.7 7.4 19.8 1.3 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 CDF34985.1 - 0.012 15.6 17.4 0.02 15.0 17.4 1.3 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 CDF34985.1 - 0.7 10.0 18.2 1.3 9.2 18.2 1.4 1 0 0 1 1 1 0 bZIP transcription factor DUF1515 PF07439.11 CDF34985.1 - 0.78 9.8 3.7 1.6 8.8 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Phlebovirus_NSM PF07246.11 CDF34985.1 - 0.85 8.9 3.9 1.2 8.4 3.9 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Cnn_1N PF07989.11 CDF34986.1 - 0.098 12.8 0.7 0.18 12.0 0.4 1.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 GP40 PF11025.8 CDF34986.1 - 0.31 10.8 3.3 0.46 10.2 3.3 1.3 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium bZIP_2 PF07716.15 CDF34986.1 - 0.52 10.4 17.7 1.4 9.1 17.7 1.7 1 1 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 CDF34986.1 - 1.9 8.6 16.3 6.4 7.0 16.3 1.8 1 1 0 1 1 1 0 bZIP transcription factor p53-inducible11 PF14936.6 CDF34988.1 - 0.0011 19.1 3.1 0.067 13.2 0.8 2.2 2 0 0 2 2 2 2 Tumour protein p53-inducible protein 11 DUF4750 PF15938.5 CDF34988.1 - 4.5 7.0 6.3 10 5.8 1.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4750) Efg1 PF10153.9 CDF34990.1 - 5.4e-20 71.9 10.9 1.3e-19 70.7 10.9 1.6 1 0 0 1 1 1 1 rRNA-processing protein Efg1 Membralin PF09746.9 CDF34990.1 - 0.048 12.7 1.5 0.058 12.4 1.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF3541 PF12060.8 CDF34990.1 - 0.1 12.3 2.1 0.13 11.9 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) Ly49 PF08391.10 CDF34990.1 - 0.39 11.1 1.7 0.5 10.7 0.8 1.6 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Spermine_synth PF01564.17 CDF34992.1 - 0.097 12.1 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Spermine/spermidine synthase domain RPN13_C PF16550.5 CDF34993.1 - 0.038 14.2 0.5 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 UCH-binding domain Chrome_Resist PF09828.9 CDF34997.1 - 0.088 13.3 2.3 1.7 9.1 0.3 2.6 2 0 0 2 2 2 0 Chromate resistance exported protein NEMP PF10225.9 CDF34997.1 - 0.27 10.9 2.9 0.61 9.7 2.9 1.7 1 0 0 1 1 1 0 NEMP family DUF1043 PF06295.12 CDF34997.1 - 0.32 11.0 6.6 0.42 10.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Pkinase PF00069.25 CDF34998.1 - 1.9e-48 165.1 0.0 2.3e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF34998.1 - 8.5e-25 87.5 0.0 1.1e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF34998.1 - 4e-07 29.2 0.0 6.7e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDF34998.1 - 6.9e-06 25.6 0.2 1.7e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF34998.1 - 0.031 14.2 0.4 1.1 9.2 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Fer2_4 PF13510.6 CDF34998.1 - 0.035 14.2 0.1 0.53 10.4 0.0 2.9 2 1 1 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain YrbL-PhoP_reg PF10707.9 CDF34998.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TRIF-NTD PF17798.1 CDF34998.1 - 0.13 12.4 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 TRIF N-terminal domain Mito_carr PF00153.27 CDF34999.1 - 3.6e-43 145.4 5.5 2.4e-19 69.0 0.2 4.2 3 1 1 4 4 4 4 Mitochondrial carrier protein L_biotic_typeA PF04604.13 CDF34999.1 - 0.018 14.9 0.0 0.089 12.7 0.0 2.1 2 0 0 2 2 2 0 Type-A lantibiotic DUF3506 PF12014.8 CDF34999.1 - 0.17 11.9 0.0 0.72 9.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) PMSR PF01625.21 CDF35000.1 - 2.4e-52 177.2 1.2 3.6e-52 176.6 1.2 1.3 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Glutaredoxin PF00462.24 CDF35000.1 - 4.3e-42 142.1 0.3 1.1e-13 51.1 0.0 3.6 3 0 0 3 3 3 3 Glutaredoxin DUF836 PF05768.14 CDF35000.1 - 1.2e-08 35.3 0.0 0.037 14.4 0.0 3.4 3 0 0 3 3 3 3 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 CDF35000.1 - 2e-08 34.7 0.2 0.56 10.7 0.0 3.7 4 0 0 4 4 4 3 Thioredoxin-like domain DSBA PF01323.20 CDF35000.1 - 7.7e-08 32.3 3.1 1.1 9.0 0.1 5.1 5 0 0 5 5 5 3 DSBA-like thioredoxin domain Thioredoxin PF00085.20 CDF35000.1 - 3.9e-05 23.6 0.1 0.08 12.9 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin DUF953 PF06110.11 CDF35000.1 - 0.0013 18.4 0.5 0.14 11.8 0.1 2.8 3 0 0 3 3 3 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_3 PF13192.6 CDF35000.1 - 0.0026 17.7 0.1 1.4 9.0 0.0 3.9 4 0 0 4 4 4 1 Thioredoxin domain Thioredoxin_7 PF13899.6 CDF35000.1 - 0.0032 17.6 0.2 7.4 6.8 0.0 3.5 3 0 0 3 3 3 1 Thioredoxin-like Redoxin PF08534.10 CDF35000.1 - 0.18 11.5 0.6 10 5.8 0.1 2.7 2 0 0 2 2 2 0 Redoxin Thioredoxin_4 PF13462.6 CDF35000.1 - 0.62 10.2 7.4 17 5.5 0.1 4.5 4 1 1 5 5 5 0 Thioredoxin zf-Di19 PF05605.12 CDF35000.1 - 2.1 8.7 4.2 34 4.8 0.2 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Bromodomain PF00439.25 CDF35001.1 - 4.4e-16 58.7 0.0 9.6e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 Bromodomain CAF1 PF04857.20 CDF35002.1 - 1.8e-45 155.5 0.0 3.6e-24 85.5 0.0 2.1 1 1 0 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.24 CDF35002.1 - 0.00058 19.7 1.0 0.001 18.9 1.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) KELK PF15796.5 CDF35002.1 - 0.076 13.5 3.6 0.14 12.6 3.6 1.3 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase zf_CCCH_4 PF18345.1 CDF35002.1 - 0.31 11.2 2.2 0.56 10.3 2.2 1.5 1 0 0 1 1 1 0 Zinc finger domain RNA_pol_L_2 PF13656.6 CDF35003.1 - 8.7e-24 83.1 0.0 1.2e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CDF35003.1 - 1.7e-06 27.3 0.0 3.2e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain T2SSE PF00437.20 CDF35003.1 - 0.064 12.3 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Coprogen_oxidas PF01218.18 CDF35004.1 - 1.3e-134 447.6 0.0 1.5e-134 447.4 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase MCM PF00493.23 CDF35005.1 - 3.6e-74 248.7 0.0 6.2e-74 247.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDF35005.1 - 2.8e-23 82.1 0.2 4.7e-23 81.4 0.2 1.3 1 0 0 1 1 1 1 MCM OB domain AAA_5 PF07728.14 CDF35005.1 - 3.9e-07 30.2 0.0 8.8e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDF35005.1 - 7e-07 28.8 0.1 0.00059 19.3 0.0 2.9 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI MCM_lid PF17855.1 CDF35005.1 - 7.9e-06 26.2 6.8 0.00089 19.6 6.8 2.6 1 1 0 1 1 1 1 MCM AAA-lid domain AAA_3 PF07726.11 CDF35005.1 - 0.0037 17.1 0.0 0.0082 16.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM_N PF14551.6 CDF35005.1 - 0.02 15.5 0.1 0.045 14.3 0.1 1.5 1 0 0 1 1 1 0 MCM N-terminal domain AAA_16 PF13191.6 CDF35005.1 - 0.17 12.3 0.4 0.87 9.9 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain PrmA PF06325.13 CDF35005.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DEAD_2 PF06733.15 CDF35006.1 - 1.5e-47 161.5 0.1 3.5e-47 160.3 0.1 1.6 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.6 CDF35006.1 - 4.1e-43 147.5 0.0 8.7e-43 146.4 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 CDF35006.1 - 2.2e-29 102.5 1.0 2e-22 79.8 0.2 2.8 2 1 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 CDF35006.1 - 4.4e-07 30.1 0.0 4.1e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF35006.1 - 0.00073 19.3 0.1 0.067 13.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 CDF35006.1 - 0.021 13.5 0.2 0.54 8.9 0.2 2.3 1 1 0 1 1 1 0 SNF2 family N-terminal domain ApoL PF05461.11 CDF35006.1 - 0.048 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein L AAA_22 PF13401.6 CDF35006.1 - 0.056 13.7 0.4 2 8.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain PQQ_3 PF13570.6 CDF35008.1 - 3.2e-05 24.3 0.1 0.017 15.6 0.0 4.1 4 0 0 4 4 4 1 PQQ-like domain PQQ PF01011.21 CDF35008.1 - 0.045 13.7 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 CDF35008.1 - 0.067 11.7 1.7 1.2 7.6 0.2 2.5 1 1 1 2 2 2 0 Cytochrome D1 heme domain V-SNARE_C PF12352.8 CDF35008.1 - 0.77 10.1 7.7 9.6 6.6 2.8 3.9 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Fez1 PF06818.15 CDF35008.1 - 6.1 7.3 60.1 0.13 12.7 3.5 4.8 2 1 2 4 4 4 0 Fez1 Atx10homo_assoc PF09759.9 CDF35009.1 - 5e-23 81.0 0.0 7.7e-21 74.0 0.0 2.5 2 0 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Glu_cyclase_2 PF05096.12 CDF35010.1 - 2.7e-82 276.0 0.0 3.5e-82 275.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine cyclotransferase SGL PF08450.12 CDF35010.1 - 0.12 11.9 0.9 9.5 5.7 0.1 3.0 2 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Gasdermin_C PF17708.1 CDF35013.1 - 0.093 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Gasdermin PUB domain DUF1347 PF07079.11 CDF35013.1 - 0.096 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) Hemerythrin PF01814.23 CDF35015.1 - 0.014 16.0 0.0 0.065 13.9 0.0 2.1 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain GTP-bdg_N PF13167.6 CDF35017.1 - 1.3e-30 105.9 0.0 2.8e-30 104.8 0.0 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 CDF35017.1 - 4.8e-30 104.0 4.6 1.1e-29 102.9 4.6 1.6 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 CDF35017.1 - 1.6e-22 79.7 0.1 3.7e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF35017.1 - 1.7e-12 47.6 0.2 9.8e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CDF35017.1 - 3.6e-12 46.1 0.2 7.5e-12 45.0 0.2 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDF35017.1 - 2.2e-06 27.4 0.1 0.0011 18.6 0.1 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain cobW PF02492.19 CDF35017.1 - 1.1e-05 25.1 6.4 0.00016 21.3 0.4 2.6 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 CDF35017.1 - 2.7e-05 24.3 0.6 0.00032 20.8 0.0 2.4 1 1 1 2 2 2 1 Dynamin family Arf PF00025.21 CDF35017.1 - 5.3e-05 22.8 1.2 0.019 14.4 0.2 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 CDF35017.1 - 9.1e-05 22.4 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Spore_IV_A PF09547.10 CDF35017.1 - 0.0045 16.0 0.0 0.0075 15.3 0.0 1.3 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) Gtr1_RagA PF04670.12 CDF35017.1 - 0.0051 16.2 0.0 0.008 15.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 CDF35017.1 - 0.0056 17.2 0.1 0.015 15.8 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 CDF35017.1 - 0.012 16.1 0.2 0.028 14.8 0.2 1.7 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 CDF35017.1 - 0.022 14.6 0.2 0.67 9.7 0.0 2.4 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 CDF35017.1 - 0.042 13.6 0.4 13 5.5 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 CDF35017.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CDF35017.1 - 0.065 13.7 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 CDF35017.1 - 0.072 13.3 0.0 0.31 11.3 0.0 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Glyco_hydro_3_C PF01915.22 CDF35017.1 - 0.098 12.6 0.1 0.23 11.4 0.1 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain Oxidored_nitro PF00148.19 CDF35017.1 - 0.1 11.3 0.0 0.84 8.3 0.0 2.1 2 1 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase YqzE PF14038.6 CDF35018.1 - 0.002 18.1 2.4 0.0055 16.7 2.4 1.7 1 0 0 1 1 1 1 YqzE-like protein GST_N_3 PF13417.6 CDF35019.1 - 1.6e-17 63.7 0.1 6.1e-17 61.8 0.0 2.0 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF35019.1 - 4.9e-14 52.4 0.0 1.1e-13 51.3 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDF35019.1 - 3.4e-13 49.7 0.0 1.7e-12 47.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDF35019.1 - 4.5e-06 26.8 0.0 7.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDF35019.1 - 0.00017 21.7 0.0 0.00049 20.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDF35019.1 - 0.0071 16.3 0.3 0.02 14.9 0.0 2.0 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain Aminotran_1_2 PF00155.21 CDF35020.1 - 8.6e-34 117.3 0.0 1.1e-33 116.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDF35020.1 - 1.3e-09 37.9 0.0 1.1e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_3 PF00202.21 CDF35020.1 - 0.02 13.6 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III Beta_elim_lyase PF01212.21 CDF35020.1 - 0.034 13.4 0.0 0.16 11.2 0.0 2.1 2 1 0 2 2 2 0 Beta-eliminating lyase Aminotran_5 PF00266.19 CDF35020.1 - 0.034 13.1 0.0 0.048 12.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Plant_tran PF04827.14 CDF35023.1 - 1.4e-41 142.3 0.0 3e-41 141.3 0.0 1.4 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF35023.1 - 2.4e-05 24.1 0.1 5.9e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease SecE PF00584.20 CDF35024.1 - 1.3e-12 47.4 0.0 2.1e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex SNF2_N PF00176.23 CDF35025.1 - 1.3e-54 185.3 0.0 7.5e-53 179.5 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF35025.1 - 9e-18 64.6 0.0 1.8e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CDF35025.1 - 3e-09 36.6 4.8 6.6e-09 35.5 4.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF35025.1 - 9.3e-09 35.5 6.0 2.5e-08 34.1 6.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF35025.1 - 9.4e-07 28.6 4.6 2.1e-06 27.5 4.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF35025.1 - 1.2e-06 28.3 2.3 1.2e-06 28.3 2.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF35025.1 - 2.7e-06 27.2 4.2 5.9e-06 26.1 4.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDF35025.1 - 3.2e-05 23.9 4.5 3.9e-05 23.6 3.3 1.8 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDF35025.1 - 0.00013 21.7 7.0 0.0041 17.0 7.4 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDF35025.1 - 0.0025 17.9 5.7 0.0051 16.9 5.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING TerY_C PF15616.6 CDF35025.1 - 0.0073 16.4 0.8 0.016 15.3 0.8 1.5 1 0 0 1 1 1 1 TerY-C metal binding domain zf-rbx1 PF12678.7 CDF35025.1 - 0.017 15.4 6.5 0.055 13.8 6.5 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 CDF35025.1 - 1 9.2 4.4 2.8 7.8 4.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SIR2 PF02146.17 CDF35028.1 - 9.4e-23 81.0 0.0 1e-21 77.7 0.0 2.2 1 1 0 1 1 1 1 Sir2 family Choline_kinase PF01633.20 CDF35029.1 - 4.4e-48 163.7 0.0 5.9e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 CDF35029.1 - 1.3e-11 44.9 0.0 2.2e-11 44.2 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF35029.1 - 0.00045 19.6 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CDF35029.1 - 0.053 12.4 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Ribosomal_L38e PF01781.18 CDF35030.1 - 1.4e-33 114.8 1.9 1.5e-33 114.7 1.9 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family BAH PF01426.18 CDF35032.1 - 0.028 14.3 0.1 0.083 12.8 0.1 1.8 1 0 0 1 1 1 0 BAH domain DUF1413 PF07205.11 CDF35032.1 - 0.14 12.2 0.6 6.3 6.9 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1413) IPK PF03770.16 CDF35037.1 - 7.1e-37 127.2 0.1 9.6e-37 126.8 0.1 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase Pkinase PF00069.25 CDF35038.1 - 4.4e-75 252.4 0.0 5e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35038.1 - 4.2e-41 141.0 0.0 4.9e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF35038.1 - 4.5e-11 42.6 0.0 1.2e-06 28.1 0.0 2.4 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 CDF35038.1 - 0.00024 20.5 0.0 0.0004 19.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF35038.1 - 0.00047 19.1 0.0 0.00066 18.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF35038.1 - 0.0089 16.0 0.0 1.4 8.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Ribosomal_S14 PF00253.21 CDF35039.1 - 1e-12 47.6 3.1 1.1e-12 47.5 3.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e AAA PF00004.29 CDF35040.1 - 2.4e-10 40.9 0.0 6.3e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF35040.1 - 4.5e-09 36.7 0.0 1.2e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Cdc6_C PF09079.11 CDF35040.1 - 1.3e-07 31.5 0.0 3.2e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_16 PF13191.6 CDF35040.1 - 0.00014 22.3 4.4 0.0031 17.9 0.1 2.8 2 1 1 3 3 3 1 AAA ATPase domain NACHT PF05729.12 CDF35040.1 - 0.0007 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_lid_10 PF17872.1 CDF35040.1 - 0.0023 18.0 0.2 0.0045 17.1 0.2 1.4 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 CDF35040.1 - 0.031 14.6 0.0 0.21 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CDF35040.1 - 0.1 12.3 0.0 0.36 10.5 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain Phytochelatin_C PF09328.10 CDF35040.1 - 0.15 11.4 0.1 0.25 10.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) AAA_7 PF12775.7 CDF35040.1 - 0.26 10.8 0.0 0.44 10.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region LAP2alpha PF11560.8 CDF35040.1 - 0.45 9.9 2.5 0.71 9.3 2.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha ATP_bind_1 PF03029.17 CDF35041.1 - 9.5e-48 163.1 0.3 1.3e-47 162.7 0.3 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 CDF35041.1 - 0.00085 18.9 0.1 0.0014 18.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CDF35041.1 - 0.0014 18.2 0.0 0.0032 17.0 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.22 CDF35041.1 - 0.0081 15.8 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 CDF35041.1 - 0.039 13.8 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase MeaB PF03308.16 CDF35041.1 - 0.067 12.2 0.2 0.15 11.0 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB GPAT_N PF14829.6 CDF35041.1 - 0.14 12.1 2.4 1.4 9.0 0.0 2.8 2 1 1 3 3 3 0 Glycerol-3-phosphate acyltransferase N-terminal YuiB PF14068.6 CDF35041.1 - 0.73 10.4 3.0 3.7 8.2 0.4 2.2 1 1 1 2 2 2 0 Putative membrane protein 2-Hacid_dh_C PF02826.19 CDF35042.1 - 3.8e-50 169.7 0.0 2e-49 167.4 0.0 2.0 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDF35042.1 - 6.5e-13 48.5 0.0 7.6e-13 48.3 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AlaDh_PNT_C PF01262.21 CDF35042.1 - 0.0068 15.7 0.2 0.011 15.0 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 CDF35042.1 - 0.061 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CDF35042.1 - 0.15 12.1 0.1 0.39 10.8 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CxC2 PF18803.1 CDF35042.1 - 0.16 12.1 0.0 0.56 10.4 0.0 1.8 1 1 1 2 2 2 0 CxC2 like cysteine cluster associated with KDZ transposases UDPG_MGDP_dh_N PF03721.14 CDF35042.1 - 0.17 11.5 0.7 0.36 10.4 0.7 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_transf_29 PF00777.18 CDF35043.1 - 2.5e-07 30.4 0.0 4.5e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) PaaX_C PF08223.11 CDF35043.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Nucleoporin2 PF04096.14 CDF35044.1 - 6.6e-36 123.7 0.0 9.1e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CDF35044.1 - 1.5e-10 41.7 62.9 2e-08 35.0 15.1 6.0 2 1 2 4 4 4 2 Nucleoporin FG repeat region Pkinase PF00069.25 CDF35049.1 - 3e-65 220.2 0.0 4.3e-65 219.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35049.1 - 1e-47 162.6 0.0 1.6e-47 162.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF35049.1 - 9.3e-05 21.4 0.0 0.00019 20.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF35049.1 - 0.0035 17.3 0.2 2.9 7.8 0.0 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF35049.1 - 0.032 13.6 0.0 0.071 12.4 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 CDF35049.1 - 0.053 12.9 0.0 0.094 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MlaE PF02405.16 CDF35050.1 - 0.12 12.1 0.0 0.12 12.1 0.0 1.0 1 0 0 1 1 1 0 Permease MlaE F-box PF00646.33 CDF35051.1 - 0.068 13.1 0.1 0.7 9.8 0.0 2.8 2 1 0 2 2 2 0 F-box domain Ribosomal_L22 PF00237.19 CDF35052.1 - 0.079 13.2 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e Amino_oxidase PF01593.24 CDF35053.1 - 2.8e-41 142.3 0.0 7.2e-41 140.9 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF35053.1 - 5.3e-09 36.2 0.1 1.2e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF35053.1 - 0.0011 18.6 0.3 0.0015 18.2 0.3 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CDF35053.1 - 0.0028 16.9 0.1 0.0056 16.0 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CDF35053.1 - 0.0074 15.4 0.1 0.012 14.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CDF35053.1 - 0.026 13.8 0.4 0.055 12.7 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDF35053.1 - 0.027 13.7 0.1 0.042 13.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CDF35053.1 - 0.055 12.2 0.8 0.11 11.2 0.0 1.8 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 CDF35053.1 - 0.072 12.2 0.8 0.13 11.4 0.0 1.8 3 0 0 3 3 3 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CDF35053.1 - 0.13 11.3 0.5 0.34 9.9 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein SH3_9 PF14604.6 CDF35053.1 - 0.16 11.8 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Inositol_P PF00459.25 CDF35054.1 - 9.8e-36 123.7 0.0 1.3e-35 123.2 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family EcKinase PF02958.20 CDF35054.1 - 6.7e-13 48.6 0.0 1.9e-12 47.2 0.0 1.7 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 CDF35054.1 - 1.1e-07 32.0 0.2 5e-07 29.9 0.2 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family ASRT PF07100.11 CDF35054.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer DUF1679 PF07914.11 CDF35054.1 - 0.19 10.6 0.0 0.35 9.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EamA PF00892.20 CDF35055.1 - 4.7e-22 78.6 19.8 4.5e-12 46.3 2.7 2.7 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 CDF35055.1 - 0.00091 18.5 3.4 0.0078 15.5 2.2 2.0 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport TPT PF03151.16 CDF35055.1 - 0.028 13.8 6.3 0.06 12.7 2.2 2.2 1 1 1 2 2 2 0 Triose-phosphate Transporter family Rubredoxin PF00301.20 CDF35056.1 - 0.00089 19.2 5.7 0.03 14.3 5.7 2.4 1 1 0 1 1 1 1 Rubredoxin zf-Mss51 PF13824.6 CDF35056.1 - 0.035 14.2 0.4 7.3 6.8 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 DZR PF12773.7 CDF35056.1 - 0.13 12.3 0.3 0.28 11.2 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon Prok-RING_1 PF14446.6 CDF35056.1 - 0.26 11.2 0.8 0.64 10.0 0.8 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Rubredoxin_2 PF18073.1 CDF35056.1 - 0.46 10.2 3.7 1.7 8.4 0.3 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain Zn_Tnp_IS1595 PF12760.7 CDF35056.1 - 0.74 9.8 5.9 3.5 7.7 0.0 2.9 3 0 0 3 3 3 0 Transposase zinc-ribbon domain DUF35_N PF12172.8 CDF35056.1 - 6.5 6.7 13.4 3.3 7.7 0.4 3.3 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Thiolase_N PF00108.23 CDF35057.1 - 7.1e-82 274.7 2.0 1e-80 270.9 2.0 2.1 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDF35057.1 - 5.4e-45 152.0 4.8 4.1e-44 149.2 2.4 2.6 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDF35057.1 - 0.00061 19.4 1.3 0.00061 19.4 1.3 3.6 2 1 2 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 CDF35057.1 - 0.13 12.5 0.2 0.59 10.4 0.1 2.1 2 0 0 2 2 2 0 Dodecin ACP_syn_III PF08545.10 CDF35057.1 - 0.97 9.3 7.2 27 4.7 0.2 3.4 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PNK3P PF08645.11 CDF35058.1 - 9.7e-50 168.4 0.0 1.5e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CDF35058.1 - 2.4e-14 53.7 0.0 9.4e-12 45.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDF35058.1 - 0.0011 18.2 0.0 0.13 11.6 0.0 2.3 1 1 1 2 2 2 2 Zeta toxin AAA_16 PF13191.6 CDF35058.1 - 0.017 15.5 0.0 0.056 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain LRR_6 PF13516.6 CDF35059.1 - 3.9e-14 51.4 5.3 0.01 15.8 0.0 6.9 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.7 CDF35059.1 - 1.4e-09 38.0 9.4 0.63 10.5 0.0 6.6 5 2 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDF35059.1 - 0.00019 21.1 11.6 2.2 8.1 0.5 5.6 4 2 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 CDF35059.1 - 0.00048 20.3 2.3 20 6.3 0.0 5.4 6 0 0 6 6 6 2 Leucine Rich Repeat Ig_C17orf99 PF17736.1 CDF35060.1 - 0.038 14.0 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 C17orf99 Ig domain DUF3138 PF11336.8 CDF35062.1 - 1.5 7.4 3.6 2.5 6.6 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) CaiF_GrlA PF07180.11 CDF35063.1 - 0.17 11.9 0.0 0.18 11.8 0.0 1.0 1 0 0 1 1 1 0 CaiF/GrlA transcriptional regulator Med27 PF11571.8 CDF35065.1 - 9.6e-10 38.7 0.0 2.8e-09 37.2 0.0 1.9 1 1 0 1 1 1 1 Mediator complex subunit 27 IMUP PF15761.5 CDF35067.1 - 0.017 15.8 5.5 0.024 15.3 5.5 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDF35067.1 - 0.042 13.5 9.8 0.057 13.0 9.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDF35067.1 - 0.57 10.5 11.2 0.83 9.9 11.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) GGACT PF06094.12 CDF35068.1 - 0.16 12.6 0.1 0.19 12.3 0.1 1.3 1 1 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like Ank_2 PF12796.7 CDF35071.1 - 1.8e-20 73.3 0.6 2.7e-09 37.5 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDF35071.1 - 2.2e-19 69.3 5.6 1.3e-08 34.9 0.1 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDF35071.1 - 4.2e-19 68.1 5.3 2.5e-05 24.5 0.1 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 CDF35071.1 - 7.9e-17 61.4 2.8 2.5e-08 34.3 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDF35071.1 - 1.8e-15 55.4 1.5 0.0098 16.3 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ribosomal_S27e PF01667.17 CDF35072.1 - 0.04 13.6 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S27 Zn_clus PF00172.18 CDF35074.1 - 0.0043 17.1 3.8 0.01 16.0 3.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DDE_3 PF13358.6 CDF35079.1 - 4.6e-19 68.6 0.0 6.4e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Uma2 PF05685.12 CDF35082.1 - 1e-18 67.5 0.2 2e-18 66.5 0.0 1.6 2 0 0 2 2 2 1 Putative restriction endonuclease Alanine_zipper PF11839.8 CDF35082.1 - 0.014 15.8 10.8 0.031 14.6 10.8 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein ATF7IP_BD PF16788.5 CDF35082.1 - 0.074 13.2 0.3 0.074 13.2 0.3 2.4 2 0 0 2 2 2 0 ATF-interacting protein binding domain DUF2381 PF09544.10 CDF35082.1 - 0.5 9.8 4.8 0.84 9.1 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) FlaG PF03646.15 CDF35082.1 - 0.7 10.1 3.8 1.3 9.2 2.9 1.9 2 0 0 2 2 2 0 FlaG protein APH PF01636.23 CDF35084.1 - 9.1e-09 35.6 0.1 1.7e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family APH PF01636.23 CDF35086.1 - 1.1e-08 35.3 0.2 2.2e-08 34.3 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DDE_3 PF13358.6 CDF35087.1 - 6.5e-17 61.7 0.0 1.1e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF35087.1 - 4.7e-12 45.6 0.0 9.7e-12 44.6 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF35087.1 - 3.6e-06 26.6 0.3 8.7e-06 25.4 0.3 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF35087.1 - 4.1e-05 24.1 2.9 0.035 14.7 0.3 2.8 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF35087.1 - 0.041 14.1 0.1 0.18 12.1 0.0 2.1 1 1 1 2 2 2 0 Transposase HTH_23 PF13384.6 CDF35087.1 - 0.074 12.9 1.0 0.49 10.2 0.0 2.6 3 0 0 3 3 3 0 Homeodomain-like domain Terminase_5 PF06056.12 CDF35087.1 - 0.26 11.2 1.9 0.34 10.8 0.0 2.1 3 0 0 3 3 3 0 Putative ATPase subunit of terminase (gpP-like) tRNA-synt_1 PF00133.22 CDF35091.1 - 1.7e-213 710.2 0.0 9.2e-213 707.8 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDF35091.1 - 2.5e-24 85.9 0.2 9.7e-24 84.1 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDF35091.1 - 1.3e-13 50.5 0.5 0.00012 21.0 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CDF35091.1 - 0.00015 21.2 0.0 0.00063 19.2 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Actin PF00022.19 CDF35092.1 - 1.3e-93 313.9 0.0 1.2e-92 310.6 0.0 1.9 1 1 0 1 1 1 1 Actin HAD_2 PF13419.6 CDF35094.1 - 3.2e-25 89.3 0.0 3.9e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF35094.1 - 3.3e-13 50.4 0.2 1.2e-12 48.6 0.2 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF35094.1 - 3.1e-11 44.0 0.0 4.5e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF35094.1 - 4.5e-07 29.8 0.1 8.6e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDF35094.1 - 8.9e-05 22.5 0.0 0.017 15.3 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PNK3P PF08645.11 CDF35094.1 - 0.0036 17.0 0.0 7.2 6.3 0.0 3.0 2 1 0 2 2 2 2 Polynucleotide kinase 3 phosphatase PetM PF08041.11 CDF35094.1 - 0.01 15.4 0.1 0.018 14.6 0.1 1.4 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Acid_PPase PF12689.7 CDF35094.1 - 0.024 14.5 0.0 1.5 8.7 0.0 2.3 2 1 0 2 2 2 0 Acid Phosphatase Hydrolase_3 PF08282.12 CDF35094.1 - 0.18 11.5 0.4 0.91 9.2 0.0 2.2 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase PRT_C PF08372.10 CDF35096.1 - 0.35 10.6 4.8 0.42 10.4 4.8 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal PALP PF00291.25 CDF35097.1 - 6.2e-66 222.8 1.4 7.1e-66 222.6 1.4 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 CDF35097.1 - 0.058 13.4 0.5 0.12 12.4 0.1 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Ribosomal_L14e PF01929.17 CDF35098.1 - 2.6e-25 88.7 0.7 3.8e-25 88.2 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CDF35098.1 - 0.041 13.9 0.2 0.085 12.8 0.2 1.6 1 0 0 1 1 1 0 KOW motif AMP-binding PF00501.28 CDF35101.1 - 1.3e-46 159.0 6.0 1.4e-31 109.6 0.0 2.7 3 0 0 3 3 3 2 AMP-binding enzyme AMP-binding_C PF13193.6 CDF35101.1 - 2.4e-05 25.2 0.0 0.00016 22.6 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 CDF35102.1 - 2.5e-30 105.8 0.0 5.1e-15 55.8 0.0 2.1 2 0 0 2 2 2 2 NAD(P)H-binding NmrA PF05368.13 CDF35102.1 - 4.1e-15 56.0 0.1 2.8e-13 50.0 0.1 2.5 2 1 0 2 2 2 1 NmrA-like family CIA30 PF08547.12 CDF35102.1 - 7.5e-15 55.3 0.0 1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Epimerase PF01370.21 CDF35102.1 - 5.8e-05 22.7 0.1 0.00013 21.5 0.1 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDF35102.1 - 0.019 14.0 0.2 0.028 13.4 0.2 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Glu_dehyd_C PF16912.5 CDF35102.1 - 0.056 12.9 0.1 0.089 12.3 0.1 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus UbiA PF01040.18 CDF35103.1 - 5e-21 75.1 10.7 6.3e-21 74.8 10.7 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family zf-CCHC_2 PF13696.6 CDF35104.1 - 0.00015 21.5 20.3 0.012 15.5 6.0 3.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 CDF35104.1 - 0.0082 15.9 17.3 0.12 12.2 0.3 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 CDF35104.1 - 0.04 14.0 2.8 0.04 14.0 2.8 4.2 5 0 0 5 5 5 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDF35104.1 - 0.046 13.6 15.4 0.087 12.7 1.8 3.0 2 0 0 2 2 2 0 Zinc knuckle Poxvirus_B22R_N PF13169.6 CDF35107.1 - 0.041 14.4 0.0 0.06 13.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus B22R protein N-terminal NIR_SIR PF01077.22 CDF35109.1 - 5e-53 178.8 0.1 1.1e-41 142.0 0.0 2.2 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CDF35109.1 - 6.6e-37 125.2 0.0 2.9e-18 65.5 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Exostosin PF03016.15 CDF35110.1 - 5.1e-44 150.7 0.0 6.2e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 Exostosin family TRAM_LAG1_CLN8 PF03798.16 CDF35112.1 - 5.6e-07 29.5 2.1 1e-06 28.6 2.1 1.6 1 1 0 1 1 1 1 TLC domain Oxidored_molyb PF00174.19 CDF35113.1 - 1.5e-54 184.2 0.0 2.5e-54 183.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CDF35113.1 - 3.8e-34 117.7 0.6 6.9e-34 116.8 0.6 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 CDF35113.1 - 2.2e-10 40.5 0.0 3.9e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BNR PF02012.20 CDF35113.1 - 0.068 13.2 0.1 0.34 11.1 0.1 2.3 1 0 0 1 1 1 0 BNR/Asp-box repeat NAP PF00956.18 CDF35115.1 - 4.6e-57 193.2 6.4 2.2e-52 177.9 0.9 2.1 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) TFIIE-A_C PF11521.8 CDF35115.1 - 0.48 10.7 2.7 2.6 8.4 0.0 2.8 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Plant_tran PF04827.14 CDF35116.1 - 8.2e-42 143.1 0.0 1.8e-41 142.0 0.0 1.4 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF35116.1 - 1.6e-05 24.6 0.0 4e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Topoisom_bac PF01131.20 CDF35117.1 - 1.2e-103 347.3 0.0 1.9e-103 346.7 0.0 1.3 1 0 0 1 1 1 1 DNA topoisomerase Toprim_C_rpt PF13368.6 CDF35117.1 - 1.5e-31 108.2 2.0 5.5e-15 55.1 0.0 4.0 4 0 0 4 4 4 3 Topoisomerase C-terminal repeat Toprim PF01751.22 CDF35117.1 - 1.7e-23 82.8 0.2 4.3e-23 81.5 0.0 1.9 2 0 0 2 2 2 1 Toprim domain Toprim_4 PF13662.6 CDF35117.1 - 0.019 15.4 0.0 0.056 13.9 0.0 1.8 1 0 0 1 1 1 0 Toprim domain MAGE_N PF12440.8 CDF35117.1 - 6.4 7.5 11.5 1.2 9.8 4.3 2.7 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal ABC_tran PF00005.27 CDF35118.1 - 2e-41 141.7 0.0 4.6e-21 75.8 0.0 4.3 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDF35118.1 - 2.3e-14 53.9 0.0 6.8e-07 29.4 0.0 3.7 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF35118.1 - 6.3e-13 48.7 0.3 0.00067 19.2 0.0 4.7 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDF35118.1 - 8.8e-08 32.9 2.9 0.027 15.0 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CDF35118.1 - 2.6e-05 23.8 0.2 0.077 12.7 0.0 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA PF00004.29 CDF35118.1 - 6.8e-05 23.3 0.0 0.21 12.0 0.0 3.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF35118.1 - 0.00021 21.5 0.2 0.38 11.0 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA_28 PF13521.6 CDF35118.1 - 0.00043 20.5 0.0 0.53 10.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CDF35118.1 - 0.00071 19.6 0.0 0.58 10.2 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DRIM PF07539.12 CDF35118.1 - 0.0021 16.5 0.2 0.84 7.9 0.0 2.4 1 1 2 3 3 3 2 Down-regulated in metastasis AAA_27 PF13514.6 CDF35118.1 - 0.003 17.2 0.1 0.35 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDF35118.1 - 0.0058 17.0 0.0 4.1 7.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Chromo PF00385.24 CDF35118.1 - 0.0062 16.4 1.0 0.0062 16.4 1.0 1.8 2 0 0 2 2 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_33 PF13671.6 CDF35118.1 - 0.0073 16.5 0.1 0.38 10.9 0.3 3.3 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CDF35118.1 - 0.0096 15.7 5.2 0.72 9.5 0.0 3.4 4 1 1 5 5 5 2 AAA ATPase domain AAA_16 PF13191.6 CDF35118.1 - 0.011 16.1 0.0 0.32 11.4 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 CDF35118.1 - 0.012 15.7 0.0 1.3 9.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDF35118.1 - 0.014 15.1 0.0 3.1 7.5 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 CDF35118.1 - 0.015 14.5 0.0 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.6 CDF35118.1 - 0.018 15.6 0.0 2 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDF35118.1 - 0.026 14.2 0.0 4.5 7.0 0.0 3.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDF35118.1 - 0.031 14.2 0.0 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase SbcCD_C PF13558.6 CDF35118.1 - 0.037 14.2 0.0 1.4 9.2 0.0 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit BP28CT PF08146.12 CDF35118.1 - 0.056 13.3 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 BP28CT (NUC211) domain Telomere_reg-2 PF10193.9 CDF35118.1 - 0.068 13.6 0.2 0.23 11.9 0.2 1.9 1 0 0 1 1 1 0 Telomere length regulation protein NACHT PF05729.12 CDF35118.1 - 0.13 12.2 0.0 5.3 6.9 0.0 2.6 2 0 0 2 2 2 0 NACHT domain CLP1_P PF16575.5 CDF35118.1 - 0.14 11.9 0.0 7.4 6.3 0.0 2.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Indigoidine_A PF04227.12 CDF35119.1 - 3.4e-85 285.9 3.7 4.3e-85 285.6 3.7 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein Band_7 PF01145.25 CDF35120.1 - 1.6e-19 70.6 1.2 4.9e-19 69.0 0.0 2.0 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CDF35120.1 - 9.4e-07 28.8 0.0 2.2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 Mito_carr PF00153.27 CDF35121.1 - 2.2e-32 110.9 6.0 3.8e-20 71.6 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein MMR_HSR1 PF01926.23 CDF35122.1 - 3e-21 75.7 0.0 1.9e-20 73.1 0.0 2.3 2 1 1 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF35122.1 - 3.9e-08 33.0 0.0 7.3e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDF35122.1 - 1e-07 32.0 0.0 0.00067 19.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase PPR_2 PF13041.6 CDF35122.1 - 2.2e-05 24.6 0.1 0.042 14.1 0.0 3.4 3 0 0 3 3 3 2 PPR repeat family Dynamin_N PF00350.23 CDF35122.1 - 0.00028 21.0 0.0 0.068 13.2 0.1 2.9 1 1 1 2 2 2 1 Dynamin family AIG1 PF04548.16 CDF35122.1 - 0.0013 18.1 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 CDF35122.1 - 0.0026 17.3 0.0 0.038 13.5 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 CDF35122.1 - 0.012 15.8 0.0 0.033 14.4 0.0 1.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PPR PF01535.20 CDF35122.1 - 0.018 15.3 0.1 2.4 8.6 0.0 3.3 3 0 0 3 3 3 0 PPR repeat SRPRB PF09439.10 CDF35122.1 - 0.036 13.5 0.0 0.081 12.4 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 CDF35122.1 - 0.14 12.7 0.0 0.4 11.2 0.0 1.9 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CDF35122.1 - 0.22 11.9 1.7 2.7 8.4 0.0 3.0 3 2 0 3 3 3 0 AAA ATPase domain PhoLip_ATPase_C PF16212.5 CDF35124.1 - 1e-76 258.0 13.2 1.3e-76 257.7 13.2 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CDF35124.1 - 8.7e-12 45.8 0.7 2.8e-06 27.8 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF35124.1 - 0.0015 18.3 0.0 0.0068 16.2 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF35124.1 - 0.053 13.6 0.0 1.6 8.8 0.0 2.5 2 0 0 2 2 2 0 Cation transport ATPase (P-type) HAD_2 PF13419.6 CDF35124.1 - 0.054 13.6 0.1 0.27 11.3 0.0 2.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF2070 PF09843.9 CDF35124.1 - 0.83 7.9 7.6 1.2 7.3 7.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PhoLip_ATPase_N PF16209.5 CDF35125.1 - 7e-19 67.3 3.5 9.4e-19 66.9 1.8 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal PRC PF05239.16 CDF35125.1 - 0.058 13.5 0.0 0.56 10.3 0.0 2.3 2 0 0 2 2 2 0 PRC-barrel domain OFeT_1 PF16955.5 CDF35125.1 - 0.16 11.6 3.6 0.051 13.3 0.6 1.6 2 0 0 2 2 2 0 Ferrous iron uptake permease, iron-lead transporter Sod_Fe_C PF02777.18 CDF35130.1 - 1e-40 138.0 0.3 3.6e-40 136.3 0.1 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDF35130.1 - 5e-27 94.2 0.1 9.4e-27 93.3 0.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain MutS_V PF00488.21 CDF35131.1 - 4e-77 258.5 0.0 7.2e-77 257.7 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CDF35131.1 - 8.8e-32 110.9 0.3 2e-31 109.7 0.3 1.7 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CDF35131.1 - 1e-11 45.0 0.9 2.1e-11 44.0 0.9 1.6 1 0 0 1 1 1 1 MutS family domain IV GMC_oxred_N PF00732.19 CDF35132.1 - 8.8e-78 261.7 0.0 1.3e-77 261.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CDF35132.1 - 1.1e-31 110.3 0.2 2.3e-31 109.2 0.2 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CDF35132.1 - 5.9e-06 26.1 0.0 0.0038 16.8 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDF35132.1 - 0.00014 21.1 0.1 0.00021 20.4 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CDF35132.1 - 0.00016 20.9 0.0 0.0089 15.1 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CDF35132.1 - 0.00041 20.5 0.0 0.00099 19.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CDF35132.1 - 0.0051 16.1 0.0 0.081 12.2 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDF35132.1 - 0.02 14.1 0.0 0.039 13.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF35132.1 - 0.03 13.1 0.0 0.042 12.5 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein UCH PF00443.29 CDF35133.1 - 1.1e-45 156.1 0.0 3.6e-45 154.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF35133.1 - 1.2e-22 81.0 7.5 3.9e-21 76.0 7.5 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CDF35133.1 - 0.024 14.1 5.0 12 5.3 0.0 3.9 4 0 0 4 4 4 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase MalM PF07148.12 CDF35133.1 - 0.097 12.4 0.1 0.33 10.7 0.1 1.9 2 0 0 2 2 2 0 Maltose operon periplasmic protein precursor (MalM) Aldedh PF00171.22 CDF35134.1 - 9.8e-124 413.4 0.4 1.1e-123 413.2 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PsbX PF06596.11 CDF35134.1 - 4.2 7.5 5.2 19 5.3 0.1 2.8 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) CENP-T_C PF15511.6 CDF35135.1 - 1.9e-08 34.4 0.1 2.3e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDF35135.1 - 0.0018 18.6 0.1 0.0029 18.0 0.1 1.5 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 CDF35135.1 - 0.0061 16.7 0.1 0.0084 16.3 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDF35135.1 - 0.0078 16.6 0.1 0.0094 16.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF35135.1 - 0.012 15.9 0.0 0.018 15.3 0.0 1.4 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDF35135.1 - 0.071 13.2 0.0 0.083 13.0 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 CDF35136.1 - 4.4e-53 179.1 1.6 4.9e-53 179.0 1.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDF35136.1 - 0.00012 22.7 1.4 0.00014 22.5 1.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDF35136.1 - 0.00013 22.0 0.4 0.00023 21.2 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDF35136.1 - 0.001 19.4 0.0 0.0016 18.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDF35136.1 - 0.01 16.1 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDF35136.1 - 0.086 12.9 0.2 0.16 12.1 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Methyltransf_11 PF08241.12 CDF35137.1 - 6.5e-12 45.9 0.0 1.3e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF35137.1 - 4.5e-10 40.1 0.0 1.1e-09 38.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF35137.1 - 2.7e-09 37.6 0.1 8e-09 36.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF35137.1 - 1.6e-07 31.3 0.0 2.6e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF35137.1 - 5.4e-07 29.5 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF35137.1 - 6.8e-05 22.3 0.0 9.7e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FMN_bind PF04205.14 CDF35138.1 - 0.0057 17.2 0.6 0.0063 17.1 0.6 1.1 1 0 0 1 1 1 1 FMN-binding domain Malectin PF11721.8 CDF35139.1 - 4.9e-09 36.5 0.0 1.3e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 Malectin domain PTP_tm PF18861.1 CDF35139.1 - 0.0022 18.0 2.1 0.0037 17.3 2.1 1.3 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF4448 PF14610.6 CDF35139.1 - 0.078 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Insulin_TMD PF17870.1 CDF35139.1 - 0.14 12.2 1.5 0.27 11.3 1.5 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF2613 PF11021.8 CDF35139.1 - 0.43 10.7 3.7 1.4 9.1 3.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) MtrF PF09472.10 CDF35139.1 - 0.63 9.5 2.9 1.4 8.3 2.9 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Pkinase PF00069.25 CDF35142.1 - 9.6e-59 198.9 0.0 1.2e-58 198.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35142.1 - 4.8e-27 94.9 0.0 5.7e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF35142.1 - 0.0019 17.5 0.0 0.017 14.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDF35142.1 - 0.009 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_60s PF00428.19 CDF35142.1 - 0.039 14.5 0.0 0.099 13.2 0.0 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein FTA2 PF13095.6 CDF35142.1 - 0.063 12.9 0.0 3.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 CDF35142.1 - 0.23 10.4 0.0 0.49 9.3 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain PMT PF02366.18 CDF35143.1 - 7.3e-30 104.3 17.6 1.9e-29 103.0 17.6 1.7 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CDF35143.1 - 8.1e-26 90.9 5.1 8.1e-26 90.9 5.1 2.4 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase PMP22_Claudin PF00822.20 CDF35143.1 - 0.0069 16.3 0.0 0.0069 16.3 0.0 2.3 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family ThiW PF09512.10 CDF35143.1 - 1.1 9.3 11.5 0.058 13.5 1.4 2.9 2 1 0 2 2 2 0 Thiamine-precursor transporter protein (ThiW) WD40 PF00400.32 CDF35144.1 - 6.9e-13 48.9 8.8 0.019 15.9 0.2 6.5 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35144.1 - 0.0042 17.3 0.0 5.2 7.4 0.0 3.8 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BppU_N PF10651.9 CDF35144.1 - 0.14 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 BppU N-terminal domain PQQ_3 PF13570.6 CDF35144.1 - 1.2 9.7 4.6 8.9 6.9 0.1 3.8 4 1 0 4 4 4 0 PQQ-like domain ACBP PF00887.19 CDF35145.1 - 2.3e-25 88.6 0.1 3e-25 88.2 0.1 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein Peptidase_C12 PF01088.21 CDF35146.1 - 1.1e-65 221.4 0.0 1.8e-65 220.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 CDF35146.1 - 1.9e-15 56.5 0.3 1.9e-15 56.5 0.3 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases DUF5323 PF17257.2 CDF35147.1 - 0.00035 20.4 4.6 0.00041 20.2 4.2 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF5323) GRAM PF02893.20 CDF35148.1 - 1.1e-07 31.7 0.0 2.1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 GRAM domain SARAF PF06682.12 CDF35148.1 - 0.85 9.2 3.4 1.3 8.7 3.4 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis APH PF01636.23 CDF35149.1 - 7.9e-07 29.2 0.1 1.3e-06 28.6 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF35149.1 - 0.00043 19.7 0.0 0.001 18.4 0.0 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 CDF35149.1 - 0.00061 19.4 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RPN2_C PF18004.1 CDF35153.1 - 0.00082 19.3 0.0 0.00082 19.3 0.0 2.4 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain RPN2_C PF18004.1 CDF35154.1 - 0.00082 19.3 0.0 0.00082 19.3 0.0 2.4 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain Retrotran_gag_2 PF14223.6 CDF35155.1 - 8.4e-33 113.0 0.4 1.3e-32 112.3 0.0 1.5 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type gag_pre-integrs PF13976.6 CDF35155.1 - 2e-07 30.7 0.0 7e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.26 CDF35155.1 - 0.0017 18.5 0.1 0.007 16.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF35155.1 - 0.31 10.8 2.1 0.82 9.4 2.1 1.7 1 0 0 1 1 1 0 Zinc knuckle CLIP1_ZNF PF16641.5 CDF35155.1 - 8.7 6.4 6.2 5.1 7.1 3.4 2.1 2 0 0 2 2 2 0 CLIP1 zinc knuckle PPC PF04151.15 CDF35157.1 - 0.005 17.9 0.0 0.065 14.3 0.1 2.3 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain Prim_Zn_Ribbon PF08273.12 CDF35157.1 - 6.9 7.0 8.3 3.5 8.0 0.1 3.0 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF3099 PF11298.8 CDF35158.1 - 0.12 12.5 1.1 0.43 10.7 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) PSRT PF07636.11 CDF35158.1 - 0.15 11.8 1.6 0.34 10.6 1.6 1.6 1 0 0 1 1 1 0 PSRT bZIP_2 PF07716.15 CDF35160.1 - 0.00048 20.1 14.3 0.00048 20.1 14.3 1.8 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CDF35160.1 - 0.058 13.5 16.1 0.1 12.7 16.1 1.4 1 1 0 1 1 1 0 bZIP transcription factor DUF1152 PF06626.12 CDF35160.1 - 0.11 11.7 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) bZIP_Maf PF03131.17 CDF35160.1 - 0.2 12.2 10.2 0.26 11.8 10.2 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.15 CDF35160.1 - 0.34 10.7 8.4 0.76 9.6 1.0 2.1 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 CDF35162.1 - 0.74 10.0 17.7 1.6 8.9 17.7 1.6 1 0 0 1 1 1 0 bZIP transcription factor Sld5 PF05916.11 CDF35163.1 - 7.6e-18 65.0 0.4 8.7e-18 64.8 0.4 1.0 1 0 0 1 1 1 1 GINS complex protein Lactamase_B_2 PF12706.7 CDF35164.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF35164.1 - 0.0034 17.4 1.4 0.012 15.6 1.9 1.8 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Pex2_Pex12 PF04757.14 CDF35165.1 - 2.7e-30 105.7 4.9 4e-30 105.1 4.9 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 CDF35165.1 - 0.00053 19.8 4.8 0.00084 19.1 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF35165.1 - 0.004 17.0 7.7 0.0063 16.3 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF35165.1 - 0.01 16.2 5.4 0.017 15.5 5.4 1.3 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 CDF35165.1 - 0.1 12.9 2.2 0.18 12.1 2.2 1.3 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDF35165.1 - 0.52 10.4 8.7 0.94 9.6 8.7 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 CDF35165.1 - 0.55 10.2 7.0 0.94 9.5 7.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 CDF35165.1 - 0.99 9.3 7.6 1.6 8.6 7.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WBS_methylT PF12589.8 CDF35166.1 - 1.6e-15 57.6 4.9 2.7e-15 56.9 4.9 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CDF35166.1 - 1.2e-08 35.5 0.0 2.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF35166.1 - 1.1e-07 32.5 0.0 2.1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF35166.1 - 0.00013 21.8 0.0 0.00038 20.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF35166.1 - 0.0052 17.5 0.0 0.012 16.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Rsm22 PF09243.10 CDF35166.1 - 0.028 13.7 0.1 0.38 10.0 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_31 PF13847.6 CDF35166.1 - 0.037 13.8 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain 2-Hacid_dh_C PF02826.19 CDF35167.1 - 7.1e-56 188.4 0.0 1.2e-55 187.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDF35167.1 - 6e-35 119.8 0.2 9.1e-35 119.2 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 CDF35167.1 - 0.00012 21.8 0.0 0.00044 20.0 0.0 2.0 2 0 0 2 2 2 1 ACT domain NAD_binding_2 PF03446.15 CDF35167.1 - 0.00012 22.3 0.9 0.017 15.3 0.1 3.2 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CDF35167.1 - 0.00076 19.1 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 CDF35167.1 - 0.011 16.3 2.7 0.012 16.2 0.1 2.4 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 CDF35167.1 - 0.048 13.9 0.3 0.43 10.8 0.0 2.7 3 0 0 3 3 3 0 TrkA-N domain ABC1 PF03109.16 CDF35168.1 - 5.3e-34 116.9 0.0 1.8e-33 115.2 0.0 2.0 3 0 0 3 3 3 1 ABC1 family Pkinase PF00069.25 CDF35168.1 - 0.0004 19.8 0.0 0.052 12.9 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain APH PF01636.23 CDF35168.1 - 0.75 9.7 9.1 57 3.5 8.3 3.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family Aldo_ket_red PF00248.21 CDF35170.1 - 7.2e-63 212.5 0.0 8.1e-63 212.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NMT PF01233.19 CDF35171.1 - 3.8e-76 254.4 0.2 7e-76 253.5 0.2 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 CDF35171.1 - 8.5e-72 241.1 0.0 1.6e-71 240.2 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 CDF35171.1 - 0.0034 17.5 0.0 0.0089 16.1 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDF35171.1 - 0.0073 16.5 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_15 PF17013.5 CDF35171.1 - 0.092 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative acetyl-transferase Pkinase_Tyr PF07714.17 CDF35173.1 - 7.3e-50 169.6 0.0 1.8e-49 168.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF35173.1 - 6e-42 143.8 0.0 1.4e-41 142.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 CDF35173.1 - 2.8e-25 88.7 0.5 8.6e-09 35.9 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDF35173.1 - 1.4e-14 54.0 5.3 1.4e-08 34.8 0.1 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDF35173.1 - 2.3e-14 53.5 0.8 8.7e-06 26.2 0.0 3.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDF35173.1 - 6.6e-10 39.0 0.6 0.00037 20.8 0.2 4.9 6 0 0 6 6 6 2 Ankyrin repeat Ank_3 PF13606.6 CDF35173.1 - 5.8e-09 35.5 0.1 0.022 15.3 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Pkinase_fungal PF17667.1 CDF35173.1 - 1.4e-05 24.1 0.0 2.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase EF-hand_6 PF13405.6 CDF35173.1 - 0.049 13.6 0.0 0.44 10.6 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain Abhydrolase_2 PF02230.16 CDF35174.1 - 1.7e-24 86.9 0.0 2.4e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CDF35174.1 - 8.3e-07 28.5 0.3 0.0058 15.9 0.1 2.6 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 CDF35174.1 - 1.5e-06 27.9 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 CDF35174.1 - 2.2e-06 28.4 1.4 2.2e-06 28.4 1.4 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDF35174.1 - 1.3e-05 24.7 0.1 0.001 18.6 0.0 2.3 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CDF35174.1 - 5.7e-05 23.1 0.2 0.027 14.3 0.1 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CDF35174.1 - 7.7e-05 22.5 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 CDF35174.1 - 0.0023 17.6 0.0 0.005 16.5 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 CDF35174.1 - 0.0049 17.0 0.0 0.022 14.9 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein Esterase_phd PF10503.9 CDF35174.1 - 0.016 14.7 1.6 0.1 12.1 0.8 2.3 2 1 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 CDF35174.1 - 0.018 14.7 0.0 0.78 9.3 0.1 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF1295 PF06966.12 CDF35176.1 - 6.6e-36 124.0 4.4 8.9e-36 123.6 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 CDF35176.1 - 5.3e-05 23.3 1.3 0.00012 22.0 0.3 2.1 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CDF35176.1 - 0.18 12.2 1.6 0.35 11.3 0.1 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase ICMT PF04140.14 CDF35176.1 - 0.19 12.2 1.2 0.47 10.9 0.1 2.4 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family SNF2_N PF00176.23 CDF35180.1 - 9.2e-58 195.6 0.0 1.4e-57 195.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF35180.1 - 1.7e-17 63.7 0.0 5.3e-17 62.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF35180.1 - 2.6e-07 30.8 0.0 5.5e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF35180.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Hydrolase_3 PF08282.12 CDF35181.1 - 6.7e-49 166.9 0.0 7.8e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDF35181.1 - 2.1e-12 47.1 0.1 7.8e-10 38.7 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDF35181.1 - 1.2e-06 29.0 0.2 0.00013 22.3 0.0 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 CDF35181.1 - 0.00091 18.4 0.0 0.0057 15.8 0.0 2.3 3 0 0 3 3 3 1 Trehalose-phosphatase HAD_2 PF13419.6 CDF35181.1 - 0.0013 18.8 0.0 0.099 12.7 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF35181.1 - 0.0029 18.1 0.0 0.36 11.2 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Transket_pyr PF02779.24 CDF35182.1 - 8.3e-44 149.4 0.0 1.2e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDF35182.1 - 7.6e-43 145.3 0.0 1.9e-42 144.1 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 CDF35182.1 - 0.0084 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II PDH PF02153.17 CDF35183.1 - 8.8e-18 64.2 0.0 1.2e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 CDF35183.1 - 3e-06 27.7 0.6 7.2e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CDF35183.1 - 3.4e-05 23.3 0.0 8.9e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDF35183.1 - 0.036 13.9 2.4 0.41 10.5 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.9 CDF35183.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain DUF4140 PF13600.6 CDF35183.1 - 0.052 14.0 0.1 0.096 13.1 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) NAD_binding_2 PF03446.15 CDF35183.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAC PF01849.18 CDF35185.1 - 3.2e-20 71.9 1.5 3.4e-20 71.8 0.1 1.8 2 0 0 2 2 2 1 NAC domain ASFV_J13L PF05568.11 CDF35185.1 - 0.72 9.6 6.3 0.12 12.1 2.0 1.8 1 1 1 2 2 2 0 African swine fever virus J13L protein Bap31_Bap29_C PF18035.1 CDF35186.1 - 0.32 11.0 11.5 0.041 13.9 6.9 1.9 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain V_ATPase_I PF01496.19 CDF35186.1 - 3.4 5.5 10.8 6.4 4.6 6.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Prp19 PF08606.11 CDF35187.1 - 1.2e-20 73.3 0.8 2.2e-20 72.4 0.8 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 CDF35187.1 - 2.2e-09 37.8 5.0 1.1 10.3 1.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat zf-Nse PF11789.8 CDF35187.1 - 0.0024 17.6 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Seryl_tRNA_N PF02403.22 CDF35187.1 - 0.0079 16.4 4.8 0.013 15.7 0.8 2.2 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain ANAPC4_WD40 PF12894.7 CDF35187.1 - 0.013 15.8 0.7 12 6.3 0.0 4.3 2 1 3 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 CDF35187.1 - 0.04 14.1 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 U-box domain HTH_8 PF02954.19 CDF35187.1 - 0.066 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Goodbye PF17109.5 CDF35187.1 - 0.44 11.0 4.5 0.27 11.7 0.3 2.2 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain Takusan PF04822.13 CDF35187.1 - 6 6.8 8.6 0.14 12.1 2.0 1.6 2 0 0 2 2 2 0 Takusan MRP-S31 PF15433.6 CDF35187.1 - 6.9 6.2 9.4 10 5.7 9.4 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DnaJ_C PF01556.18 CDF35188.1 - 1.2e-38 132.5 0.0 1.7e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDF35188.1 - 2.1e-21 75.8 0.1 3.3e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDF35188.1 - 6.2e-14 52.1 13.2 1e-13 51.4 13.2 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CDF35188.1 - 0.016 15.1 9.7 0.11 12.5 2.4 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein PYNP_C PF07831.13 CDF35188.1 - 0.032 13.9 0.6 1.8 8.3 0.2 2.4 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain HypA PF01155.19 CDF35188.1 - 0.21 11.6 4.1 9 6.4 0.1 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_C7 PF14522.6 CDF35188.1 - 4.2 7.4 6.1 15 5.6 3.8 2.5 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c Sld5 PF05916.11 CDF35189.1 - 4.5e-19 68.9 0.8 7.2e-19 68.3 0.8 1.3 1 0 0 1 1 1 1 GINS complex protein DDE_3 PF13358.6 CDF35190.1 - 1e-10 41.6 0.0 1.8e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF35190.1 - 1.2e-07 31.4 0.0 3.8e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF35190.1 - 2.6e-05 23.9 0.0 5.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDF35190.1 - 0.00064 19.9 0.3 0.0015 18.7 0.3 1.7 1 0 0 1 1 1 1 Transposase Glyco_hydro_45 PF02015.16 CDF35191.1 - 2.4e-09 37.4 14.9 3.3e-08 33.7 5.7 2.7 2 1 1 3 3 3 2 Glycosyl hydrolase family 45 DAO PF01266.24 CDF35192.1 - 1.4e-33 117.0 0.0 1.9e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CDF35192.1 - 7.1e-05 23.2 0.0 0.00018 21.9 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 CDF35192.1 - 0.00037 19.8 0.0 0.0011 18.3 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF35192.1 - 0.00049 19.3 0.4 0.00091 18.4 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CDF35192.1 - 0.0034 17.9 2.0 0.009 16.5 2.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDF35192.1 - 0.0064 15.8 0.5 0.01 15.1 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CDF35192.1 - 0.013 14.8 1.1 0.022 14.0 1.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 CDF35192.1 - 0.037 14.3 0.7 0.1 12.8 0.7 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CDF35192.1 - 0.044 12.9 0.8 0.07 12.2 0.8 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A ATP-grasp_3 PF02655.14 CDF35192.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain UDPG_MGDP_dh_N PF03721.14 CDF35192.1 - 0.12 11.9 0.7 0.21 11.2 0.7 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.6 CDF35192.1 - 0.18 11.0 0.2 0.3 10.3 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDF35195.1 - 3.8e-31 108.9 0.0 5.5e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CDF35195.1 - 0.00019 21.9 0.0 0.00048 20.5 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 CDF35195.1 - 0.0003 20.1 0.0 0.00085 18.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF35195.1 - 0.00051 19.2 0.4 0.00086 18.5 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CDF35195.1 - 0.0031 18.0 2.0 0.0085 16.6 2.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDF35195.1 - 0.011 15.0 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CDF35195.1 - 0.011 15.0 1.1 0.021 14.1 1.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 CDF35195.1 - 0.035 14.4 0.7 0.099 12.9 0.7 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ATP-grasp_3 PF02655.14 CDF35195.1 - 0.037 14.1 0.0 0.084 12.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain GIDA PF01134.22 CDF35195.1 - 0.041 13.0 0.8 0.066 12.3 0.8 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 CDF35195.1 - 0.12 11.9 0.8 0.21 11.2 0.8 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.6 CDF35195.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase APH PF01636.23 CDF35199.1 - 1.8e-18 67.3 1.6 2.8e-18 66.7 1.6 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF35199.1 - 0.0013 18.4 0.6 0.0057 16.3 0.3 1.9 2 0 0 2 2 2 1 RIO1 family Fructosamin_kin PF03881.14 CDF35199.1 - 0.0039 16.5 0.0 0.87 8.7 0.0 2.2 2 0 0 2 2 2 2 Fructosamine kinase Choline_kinase PF01633.20 CDF35199.1 - 0.0084 15.7 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 CDF35199.1 - 0.017 14.2 0.1 0.035 13.2 0.1 1.5 1 1 0 1 1 1 0 Seadornavirus VP7 DUF1679 PF07914.11 CDF35199.1 - 0.054 12.4 0.3 0.085 11.7 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 CDF35199.1 - 0.064 12.6 0.0 0.17 11.2 0.1 1.7 2 0 0 2 2 2 0 Protein kinase domain WW PF00397.26 CDF35200.1 - 0.011 15.8 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 WW domain Metallophos PF00149.28 CDF35202.1 - 4e-06 27.5 0.5 9.6e-06 26.2 0.5 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TraB PF01963.17 CDF35202.1 - 0.12 12.3 2.2 2.7 7.8 0.3 2.9 3 0 0 3 3 3 0 TraB family SPAN-X PF07458.12 CDF35202.1 - 9.5 6.7 6.3 21 5.6 0.3 3.4 3 0 0 3 3 3 0 Sperm protein associated with nucleus, mapped to X chromosome Mre11_DNA_bind PF04152.14 CDF35204.1 - 1.3e-26 93.9 0.0 5.3e-26 91.9 0.0 2.0 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 CDF35204.1 - 5.5e-14 53.1 0.2 1e-13 52.3 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF35204.1 - 0.012 15.8 0.0 0.082 13.1 0.0 2.3 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Polyketide_cyc PF03364.20 CDF35205.1 - 6e-12 45.9 0.0 8.3e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 CDF35205.1 - 4.2e-06 27.1 0.0 6.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 CDF35205.1 - 0.025 14.3 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit G (CoxG) FAD_binding_7 PF03441.14 CDF35207.1 - 1.9e-51 174.4 0.0 3.6e-51 173.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CDF35207.1 - 3.2e-30 105.3 0.1 1.2e-28 100.2 0.1 2.8 2 1 0 2 2 2 1 DNA photolyase S19 PF06756.11 CDF35207.1 - 0.71 9.9 5.3 5.3 7.1 0.3 3.7 2 1 1 3 3 3 0 Chorion protein S19 C-terminal DUF4992 PF16383.5 CDF35208.1 - 0.1 12.2 0.3 0.27 10.7 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function Branch PF02485.21 CDF35210.1 - 3.5e-34 118.4 1.2 4.7e-34 118.0 1.2 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Pkinase PF00069.25 CDF35219.1 - 8.2e-69 231.9 0.0 9.9e-69 231.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35219.1 - 1.4e-34 119.6 0.0 1.8e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF35219.1 - 3.7e-08 33.6 0.5 0.00072 19.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDF35219.1 - 6.5e-07 28.9 0.1 1.4e-06 27.8 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF35219.1 - 1.6e-05 24.4 0.0 3.1e-05 23.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 CDF35219.1 - 0.00015 21.4 0.1 0.00028 20.5 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 CDF35219.1 - 0.019 14.6 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 CDF35219.1 - 0.046 13.2 0.1 0.099 12.2 0.1 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Cwf_Cwc_15 PF04889.12 CDF35220.1 - 1.4e-58 198.6 14.2 1.6e-58 198.4 14.2 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 CDF35220.1 - 0.023 14.1 16.9 0.028 13.9 16.9 1.3 1 0 0 1 1 1 0 SDA1 HTH_Tnp_Tc3_1 PF11427.8 CDF35221.1 - 3e-07 30.2 0.1 6.2e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF35221.1 - 0.00026 20.7 2.8 0.00038 20.1 0.1 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF35221.1 - 0.036 13.9 1.7 1.7 8.5 0.0 3.2 3 1 0 3 3 3 0 Homeodomain-like domain HTH_11 PF08279.12 CDF35221.1 - 0.083 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 HTH domain DDE_3 PF13358.6 CDF35222.1 - 1e-09 38.3 0.0 1.5e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease GcpE PF04551.14 CDF35225.1 - 4.1e-139 463.5 0.0 4.8e-139 463.3 0.0 1.0 1 0 0 1 1 1 1 GcpE protein RNase_H PF00075.24 CDF35226.1 - 2.7e-38 131.4 0.0 4.5e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 CDF35226.1 - 6.7e-29 99.9 4.8 3.7e-14 52.8 1.6 2.3 2 0 0 2 2 2 2 Caulimovirus viroplasmin HTH_9 PF08221.11 CDF35227.1 - 0.00046 20.2 0.4 4.5 7.5 0.0 3.5 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 CDF35227.1 - 0.012 15.5 0.1 0.048 13.5 0.1 2.1 2 0 0 2 2 2 0 TFIIE alpha subunit MutL_C PF08676.11 CDF35229.1 - 2.2e-15 56.7 0.0 4e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CDF35229.1 - 2.3e-12 46.7 0.0 5.6e-12 45.4 0.0 1.7 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain Ubiq-assoc PF09145.10 CDF35229.1 - 0.21 11.6 0.0 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-associated Mog1 PF04603.12 CDF35231.1 - 4.4e-33 114.6 0.0 5.9e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein FKBP_C PF00254.28 CDF35232.1 - 3.2e-29 101.1 0.1 8.6e-29 99.7 0.0 1.8 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase AAA PF00004.29 CDF35234.1 - 1.6e-34 119.2 0.0 7.4e-21 74.9 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF35234.1 - 3.7e-15 56.7 0.7 4.7e-07 30.4 0.3 3.5 3 1 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CDF35234.1 - 5.5e-08 32.9 0.1 0.01 15.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF35234.1 - 9.3e-08 32.4 0.0 0.0024 18.1 0.0 3.1 2 1 1 3 3 3 2 AAA domain Mg_chelatase PF01078.21 CDF35234.1 - 2.9e-07 30.1 0.1 0.0019 17.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CDF35234.1 - 5.7e-07 29.4 0.0 0.039 13.7 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 CDF35234.1 - 2e-06 27.5 0.0 0.025 14.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region RsgA_GTPase PF03193.16 CDF35234.1 - 7.7e-06 25.9 0.1 0.0051 16.7 0.0 3.3 2 1 2 4 4 3 1 RsgA GTPase Sigma54_activat PF00158.26 CDF35234.1 - 1.6e-05 24.6 0.0 0.034 13.9 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain RNA_helicase PF00910.22 CDF35234.1 - 9e-05 22.8 0.0 0.35 11.3 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.14 CDF35234.1 - 0.00014 22.0 0.0 0.33 11.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) T2SSE PF00437.20 CDF35234.1 - 0.00021 20.4 0.1 0.2 10.7 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_24 PF13479.6 CDF35234.1 - 0.00025 20.8 0.0 0.18 11.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 CDF35234.1 - 0.00028 20.1 0.0 0.047 12.8 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF815) TsaE PF02367.17 CDF35234.1 - 0.00042 20.3 0.1 1.2 9.1 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CDF35234.1 - 0.00048 20.3 0.0 0.019 15.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CDF35234.1 - 0.00056 19.6 0.5 0.053 13.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CDF35234.1 - 0.0006 20.3 0.0 0.29 11.6 0.0 2.4 2 0 0 2 2 2 1 ABC transporter ATPase_2 PF01637.18 CDF35234.1 - 0.001 19.0 0.0 0.13 12.1 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 CDF35234.1 - 0.0014 19.1 0.0 0.38 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDF35234.1 - 0.0023 17.5 1.8 0.55 9.8 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_14 PF13173.6 CDF35234.1 - 0.0036 17.3 0.0 2.2 8.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDF35234.1 - 0.0045 16.2 0.2 2.7 7.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Urb2 PF10441.9 CDF35234.1 - 0.0047 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Urb2/Npa2 family TniB PF05621.11 CDF35234.1 - 0.0059 16.0 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein PhoH PF02562.16 CDF35234.1 - 0.0077 15.7 0.1 3.3 7.1 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_30 PF13604.6 CDF35234.1 - 0.01 15.6 0.0 1.6 8.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDF35234.1 - 0.01 15.7 0.1 4.8 7.1 0.0 3.2 3 0 0 3 3 3 0 NACHT domain Rad17 PF03215.15 CDF35234.1 - 0.016 15.2 0.2 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain PduV-EutP PF10662.9 CDF35234.1 - 0.025 14.3 0.0 9.4 6.0 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_8 PF12780.7 CDF35234.1 - 0.05 12.9 0.0 3.9 6.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_23 PF13476.6 CDF35234.1 - 0.055 14.0 0.1 18 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDF35234.1 - 0.067 12.5 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin NB-ARC PF00931.22 CDF35234.1 - 0.069 12.3 0.0 2.9 7.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain RuvB_N PF05496.12 CDF35234.1 - 0.07 12.9 0.1 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain KAP_NTPase PF07693.14 CDF35234.1 - 0.087 12.0 0.0 6.9 5.8 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain Roc PF08477.13 CDF35234.1 - 0.11 12.7 0.0 0.82 9.9 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 CDF35234.1 - 0.11 12.4 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_PrkA PF08298.11 CDF35234.1 - 0.14 11.0 0.0 0.81 8.5 0.0 2.0 2 0 0 2 2 2 0 PrkA AAA domain AAA_28 PF13521.6 CDF35234.1 - 0.15 12.3 0.0 3 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CDF35234.1 - 0.16 12.0 0.0 0.54 10.4 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase Guanylate_kin PF00625.21 CDF35234.1 - 0.19 11.4 0.0 9.1 5.9 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase AAA_6 PF12774.7 CDF35234.1 - 0.2 10.6 0.0 5.3 5.9 0.0 2.2 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Adeno_IVa2 PF02456.15 CDF35234.1 - 0.23 10.2 0.0 8.6 5.0 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein DDE_Tnp_1_assoc PF13808.6 CDF35237.1 - 0.074 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-associated ubiquitin PF00240.23 CDF35239.1 - 6.2e-09 35.5 0.0 9.8e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CDF35239.1 - 2.5e-05 24.3 0.0 5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CDF35239.1 - 0.00015 22.3 0.0 0.00029 21.4 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Pkinase_Tyr PF07714.17 CDF35240.1 - 2.8e-61 207.1 0.0 4.2e-61 206.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF35240.1 - 3.3e-52 177.5 0.0 5.2e-52 176.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TIR_2 PF13676.6 CDF35240.1 - 1.6e-11 44.8 0.0 4.9e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 TIR domain TIR PF01582.20 CDF35240.1 - 3.8e-05 23.5 0.0 6.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 TIR domain APH PF01636.23 CDF35240.1 - 0.13 12.2 0.1 0.56 10.1 0.0 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Lactamase_B_6 PF16661.5 CDF35241.1 - 8e-50 169.0 0.0 4.5e-49 166.5 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 CDF35241.1 - 2e-20 73.7 5.4 5.4e-20 72.3 0.2 3.1 2 1 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 CDF35241.1 - 4.7e-20 71.9 0.0 1.1e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 CDF35241.1 - 5.2e-09 35.9 0.0 1.3e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 CDF35241.1 - 1.4e-05 25.2 1.2 2.9e-05 24.2 1.2 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF35241.1 - 0.0095 15.5 0.0 0.022 14.3 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain SSFA2_C PF14723.6 CDF35241.1 - 0.039 13.9 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus Esterase PF00756.20 CDF35242.1 - 0.00019 21.1 0.6 0.00049 19.8 0.6 1.7 1 1 0 1 1 1 1 Putative esterase RPE65 PF03055.15 CDF35244.1 - 1.3e-72 245.5 0.0 1.5e-72 245.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF918 PF06033.11 CDF35244.1 - 0.077 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) Pkinase PF00069.25 CDF35247.1 - 0.083 12.2 0.0 0.26 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain Pkinase PF00069.25 CDF35248.1 - 0.011 15.1 0.1 0.052 12.9 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Kdo PF06293.14 CDF35248.1 - 0.012 15.0 0.2 0.056 12.8 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tna_leader PF08053.11 CDF35249.1 - 0.91 9.6 3.1 1 9.4 0.5 2.4 2 0 0 2 2 2 0 Tryptophanase operon leader peptide Epimerase PF01370.21 CDF35251.1 - 4.7e-14 52.4 0.0 3.3e-12 46.4 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CDF35251.1 - 2.2e-09 37.4 0.1 7.2e-09 35.8 0.1 2.0 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CDF35251.1 - 2.8e-09 36.8 0.0 0.0023 17.4 0.0 2.3 3 0 0 3 3 3 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDF35251.1 - 4.2e-07 29.4 0.0 7.8e-06 25.2 0.0 2.2 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CDF35251.1 - 5e-07 29.5 0.0 7.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Pyr_redox_3 PF13738.6 CDF35251.1 - 0.0012 18.2 0.0 0.0025 17.1 0.0 1.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Glyco_trans_4_4 PF13579.6 CDF35251.1 - 0.0081 16.6 0.0 0.028 14.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain adh_short PF00106.25 CDF35251.1 - 0.0086 15.6 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.19 CDF35251.1 - 0.013 14.5 0.1 4 6.4 0.0 3.0 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox_2 PF07992.14 CDF35251.1 - 0.016 14.5 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_transf_4 PF13439.6 CDF35251.1 - 0.09 12.8 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DUF1188 PF06690.11 CDF35251.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) GCN5L1 PF06320.13 CDF35253.1 - 3.8e-21 75.4 4.4 4.5e-21 75.1 4.4 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) PspA_IM30 PF04012.12 CDF35253.1 - 0.06 12.9 3.7 0.042 13.4 0.6 1.9 1 1 1 2 2 2 0 PspA/IM30 family BLOC1_2 PF10046.9 CDF35253.1 - 0.32 11.3 5.8 0.047 14.0 2.0 1.6 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-4CXXC_R1 PF10497.9 CDF35255.1 - 5.4e-05 23.3 16.1 0.00012 22.2 16.1 1.5 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C3HC4_3 PF13920.6 CDF35255.1 - 6.8 6.6 14.5 21 5.1 14.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AATase PF07247.12 CDF35256.1 - 0.098 11.2 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Alcohol acetyltransferase SKI PF01202.22 CDF35257.1 - 4e-10 40.1 0.0 4.4e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase CPT PF07931.12 CDF35257.1 - 9e-05 22.4 0.1 0.00048 20.0 0.1 1.9 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 CDF35257.1 - 0.00053 20.5 0.0 0.0012 19.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CDF35257.1 - 0.0097 15.7 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase APS_kinase PF01583.20 CDF35257.1 - 0.019 14.8 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.6 CDF35257.1 - 0.02 15.3 0.0 0.024 15.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CDF35257.1 - 0.022 14.9 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF35257.1 - 0.047 14.2 0.0 0.085 13.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CDF35257.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain IBN_N PF03810.19 CDF35258.1 - 1.1e-08 34.9 0.0 3.4e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 CDF35258.1 - 0.00034 20.9 17.6 0.84 10.1 0.2 6.8 4 2 5 9 9 9 4 HEAT repeats IFRD PF05004.13 CDF35258.1 - 0.0012 18.0 4.9 0.032 13.4 3.2 2.6 1 1 1 2 2 2 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 CDF35258.1 - 0.0029 18.1 9.8 0.45 11.1 0.0 6.7 6 0 0 6 6 6 1 HEAT-like repeat MMS19_C PF12460.8 CDF35258.1 - 0.0079 15.3 0.0 4 6.4 0.0 2.9 2 1 0 2 2 2 2 RNAPII transcription regulator C-terminal HEAT PF02985.22 CDF35258.1 - 0.074 13.3 0.0 0.074 13.3 0.0 6.6 8 0 0 8 8 8 0 HEAT repeat Acyl_transf_1 PF00698.21 CDF35259.1 - 3.6e-31 108.9 1.0 4.5e-31 108.5 1.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain Ribosomal_L18A PF01775.17 CDF35260.1 - 4.8e-49 165.5 1.7 6e-49 165.2 1.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A MitMem_reg PF13012.6 CDF35261.1 - 5.7e-34 116.9 0.1 1.2e-33 115.9 0.1 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CDF35261.1 - 1.5e-29 102.3 0.0 2.4e-29 101.7 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MOSC_N PF03476.16 CDF35262.1 - 2.1e-30 105.0 0.0 3.9e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 CDF35262.1 - 5.6e-25 87.9 0.0 1.1e-24 86.9 0.0 1.5 1 0 0 1 1 1 1 MOSC domain DUF1884 PF08967.10 CDF35262.1 - 0.03 14.6 0.0 0.081 13.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1884) PARP PF00644.20 CDF35263.1 - 1.9e-46 158.1 0.0 5e-46 156.8 0.0 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 CDF35263.1 - 8.6e-37 126.3 0.1 1.8e-36 125.2 0.1 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 CDF35263.1 - 3e-22 78.5 3.6 3e-22 78.5 3.6 1.9 2 0 0 2 2 2 1 WGR domain Deltaretro_Tax PF05599.11 CDF35264.1 - 0.017 15.7 1.4 0.031 14.8 1.0 1.7 1 1 1 2 2 2 0 Deltaretrovirus Tax protein Mlh1_C PF16413.5 CDF35267.1 - 2.6e-56 191.0 0.0 4.4e-56 190.2 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CDF35267.1 - 1.3e-26 92.6 0.1 2.1e-26 92.0 0.1 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CDF35267.1 - 5e-12 45.8 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDF35267.1 - 2.5e-06 28.0 0.0 1.1e-05 25.8 0.0 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3HCDH_N PF02737.18 CDF35267.1 - 0.037 13.9 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RPN13_C PF16550.5 CDF35269.1 - 0.13 12.5 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 UCH-binding domain NACHT_sigma PF17106.5 CDF35270.1 - 0.15 12.3 0.8 0.41 10.8 0.8 1.8 1 0 0 1 1 1 0 Sigma domain on NACHT-NTPases DUF2613 PF11021.8 CDF35270.1 - 1.1 9.5 5.2 1.7 8.8 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2613) Complex1_LYR PF05347.15 CDF35272.1 - 3e-09 36.8 1.4 4e-09 36.4 1.4 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 CDF35272.1 - 0.0064 17.1 0.1 0.0092 16.6 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.6 CDF35272.1 - 0.0079 16.9 0.0 0.0092 16.7 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like LSM PF01423.22 CDF35274.1 - 6e-16 57.9 0.0 8.8e-16 57.4 0.0 1.3 1 0 0 1 1 1 1 LSM domain Pet100 PF09803.9 CDF35274.1 - 0.067 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Pet100 S-AdoMet_synt_N PF00438.20 CDF35274.1 - 0.13 12.9 0.1 0.29 11.9 0.0 1.5 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain dCMP_cyt_deam_1 PF00383.23 CDF35275.1 - 5e-08 32.7 0.7 1e-07 31.8 0.7 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDF35275.1 - 3.1e-06 27.0 0.7 7.8e-06 25.7 0.7 1.6 1 0 0 1 1 1 1 MafB19-like deaminase WD40 PF00400.32 CDF35276.1 - 9.7e-13 48.4 3.5 0.00098 19.9 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35276.1 - 2.1e-05 24.7 1.1 0.002 18.4 0.2 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF35276.1 - 0.0057 15.4 0.7 0.05 12.2 0.1 2.1 1 1 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 CDF35276.1 - 0.0068 15.8 0.0 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 WD40-like domain UPF0004 PF00919.20 CDF35279.1 - 3.5e-27 94.3 0.2 1.4e-26 92.4 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 CDF35279.1 - 3e-26 92.8 0.1 5.1e-26 92.0 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.20 CDF35279.1 - 1.9e-11 43.7 0.2 3.3e-11 43.0 0.2 1.4 1 0 0 1 1 1 1 TRAM domain Rotamase PF00639.21 CDF35279.1 - 4.4e-07 30.8 0.1 1e-05 26.4 0.0 3.0 3 0 0 3 3 3 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CDF35279.1 - 1.2e-05 25.8 0.0 7.8e-05 23.2 0.0 2.3 3 0 0 3 3 3 1 PPIC-type PPIASE domain TRAM_2 PF18693.1 CDF35279.1 - 0.0019 18.3 0.0 0.0074 16.4 0.0 2.0 1 1 0 1 1 1 1 TRAM domain MttA_Hcf106 PF02416.16 CDF35280.1 - 2.8e-09 36.2 3.7 5.3e-09 35.3 3.7 1.5 1 1 0 1 1 1 1 mttA/Hcf106 family DREPP PF05558.12 CDF35280.1 - 0.015 15.2 1.7 0.019 14.9 1.7 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Pkinase PF00069.25 CDF35281.1 - 2.6e-60 204.1 0.0 3.1e-60 203.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35281.1 - 7.1e-38 130.4 0.0 1.1e-37 129.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF35281.1 - 5.3e-05 22.7 0.1 9.2e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF35281.1 - 0.0091 15.0 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 CDF35281.1 - 0.019 14.0 0.0 0.026 13.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 CDF35281.1 - 0.032 13.5 0.1 0.28 10.5 0.0 2.4 2 1 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 CDF35281.1 - 0.033 13.0 0.0 0.052 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RTC PF01137.21 CDF35284.1 - 3.1e-42 144.3 0.0 3.6e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 CDF35284.1 - 2.3e-25 89.1 0.0 4.8e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Peptidase_C27 PF05407.12 CDF35284.1 - 0.052 13.6 0.5 0.093 12.8 0.5 1.4 1 0 0 1 1 1 0 Rubella virus endopeptidase Glyco_hydro_1 PF00232.18 CDF35285.1 - 1.7e-162 541.0 3.4 1.9e-162 540.8 3.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_1 PF00232.18 CDF35287.1 - 3.7e-157 523.4 0.8 4.5e-157 523.1 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 DnaJ PF00226.31 CDF35288.1 - 2.3e-22 78.9 0.1 6e-22 77.5 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.11 CDF35288.1 - 1.2e-06 28.7 2.3 3.4e-06 27.2 2.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) Thioredox_DsbH PF03190.15 CDF35289.1 - 4.3e-52 176.4 0.0 8.1e-51 172.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 CDF35289.1 - 5.7e-07 29.6 0.1 2.2e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like Glyco_hydro_88 PF07470.13 CDF35289.1 - 0.00056 19.1 0.0 0.48 9.4 0.0 3.4 3 1 0 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 CDF35289.1 - 0.0016 17.9 4.0 0.22 11.0 0.1 3.1 2 1 1 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Sigma70_r3 PF04539.16 CDF35289.1 - 0.05 13.7 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-70 region 3 Glyco_hydro_127 PF07944.12 CDF35289.1 - 0.11 10.9 0.3 0.27 9.7 0.0 1.7 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Cation_efflux PF01545.21 CDF35290.1 - 5.4e-50 169.9 6.7 6.5e-50 169.6 6.7 1.1 1 0 0 1 1 1 1 Cation efflux family DUF2946 PF11162.8 CDF35290.1 - 9 7.0 6.3 10 6.8 3.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) Glycos_transf_1 PF00534.20 CDF35291.1 - 8.3e-30 103.6 0.0 1.6e-29 102.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF35291.1 - 2e-25 89.8 0.0 4.1e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDF35291.1 - 4.8e-19 69.0 0.0 1.4e-18 67.5 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDF35291.1 - 8.6e-13 49.0 0.0 8.6e-13 49.0 0.0 2.6 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CDF35291.1 - 6.7e-12 45.6 0.0 2.2e-11 44.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 CDF35291.1 - 1.9e-05 24.7 0.0 4.2e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase 4-like SOUL PF04832.12 CDF35292.1 - 6.1e-35 120.9 0.0 7e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein Aminotran_4 PF01063.19 CDF35294.1 - 1.6e-32 113.2 0.0 8.5e-32 110.8 0.0 1.9 2 0 0 2 2 2 1 Amino-transferase class IV SSB PF00436.25 CDF35297.1 - 1.6e-12 47.3 0.1 2.2e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Arr-ms PF12120.8 CDF35297.1 - 0.16 12.2 0.0 0.48 10.6 0.0 1.7 2 0 0 2 2 2 0 Rifampin ADP-ribosyl transferase DUF5547 PF17701.1 CDF35297.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5547) Spt20 PF12090.8 CDF35298.1 - 1.2 8.7 50.8 0.52 9.9 27.7 2.2 2 0 0 2 2 2 0 Spt20 family Lin-8 PF03353.15 CDF35298.1 - 2.2 7.8 29.2 3.4 7.1 9.2 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF3347 PF11827.8 CDF35298.1 - 7.8 6.6 13.7 1.1 9.4 4.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) SOUL PF04832.12 CDF35299.1 - 1.3e-20 74.2 0.0 1.5e-20 74.0 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein tRNA-synt_1g PF09334.11 CDF35301.1 - 6.5e-147 489.4 0.0 8.1e-147 489.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA_bind PF01588.20 CDF35301.1 - 5.7e-25 87.3 0.7 1e-24 86.5 0.7 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain tRNA-synt_1 PF00133.22 CDF35301.1 - 7.8e-07 27.7 0.6 0.0017 16.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CDF35301.1 - 0.023 14.1 0.1 0.07 12.5 0.1 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DZR PF12773.7 CDF35301.1 - 0.057 13.5 6.5 0.047 13.7 5.0 1.7 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 CDF35301.1 - 0.4 10.7 3.3 27 4.8 3.3 2.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1610 PF07754.11 CDF35301.1 - 3.5 7.7 11.4 0.15 12.1 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) zf-ribbon_3 PF13248.6 CDF35301.1 - 4.3 6.9 10.5 9.5 5.8 0.3 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Pkinase PF00069.25 CDF35302.1 - 0.018 14.4 0.0 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain HTH_Tnp_Tc3_1 PF11427.8 CDF35304.1 - 0.00015 21.5 0.3 0.00028 20.7 0.0 1.6 2 0 0 2 2 2 1 Tc3 transposase HTH_38 PF13936.6 CDF35304.1 - 0.0021 17.8 0.3 0.043 13.6 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain Terminase_5 PF06056.12 CDF35304.1 - 0.029 14.2 0.0 0.069 13.0 0.0 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DDE_3 PF13358.6 CDF35305.1 - 1.9e-11 43.9 0.0 2.9e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M22 PF00814.25 CDF35306.1 - 5.7e-88 295.1 0.0 6.6e-88 294.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CDF35306.1 - 0.14 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus Toxin_11 PF07473.11 CDF35307.1 - 0.063 13.4 1.1 0.16 12.1 1.1 1.7 1 0 0 1 1 1 0 Spasmodic peptide gm9a; conotoxin from Conus species WD40 PF00400.32 CDF35308.1 - 1.3e-15 57.5 3.4 0.0013 19.5 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35308.1 - 5.6e-12 45.8 0.1 0.026 14.8 0.0 5.1 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDF35308.1 - 0.017 15.0 0.2 18 5.4 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Brr6_like_C_C PF10104.9 CDF35309.1 - 1.1e-17 64.1 0.1 1.3e-17 63.9 0.1 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Pilin_N PF07790.11 CDF35309.1 - 0.036 15.0 2.7 4 8.4 0.4 2.2 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal Trans_reg_C PF00486.28 CDF35309.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal HSP90 PF00183.18 CDF35310.1 - 8e-227 754.2 31.9 1.5e-226 753.3 31.9 1.3 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CDF35310.1 - 1.3e-11 45.0 0.0 2.7e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDF35310.1 - 1.4e-09 37.9 0.0 3.9e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 CDF35310.1 - 0.025 14.6 0.2 0.15 12.1 0.2 2.2 2 0 0 2 2 2 0 Tumour suppressor protein FAR1 PF03101.15 CDF35310.1 - 0.029 15.0 0.7 0.096 13.4 0.7 1.9 1 0 0 1 1 1 0 FAR1 DNA-binding domain DUF2722 PF10846.8 CDF35310.1 - 6.5 5.6 10.4 14 4.4 10.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pkinase PF00069.25 CDF35311.1 - 3.1e-66 223.4 0.0 3.6e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35311.1 - 1.8e-27 96.3 0.0 2.2e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF35311.1 - 0.0018 18.3 0.0 0.14 12.0 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF35311.1 - 0.0065 15.8 0.0 0.0097 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF35311.1 - 0.015 14.3 0.0 0.026 13.5 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain PHD PF00628.29 CDF35312.1 - 2.1e-05 24.3 6.9 2.1e-05 24.3 6.9 2.9 3 0 0 3 3 3 1 PHD-finger PHD_2 PF13831.6 CDF35312.1 - 0.0032 17.0 3.6 0.0061 16.1 2.3 2.2 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H_2 PF13832.6 CDF35312.1 - 0.0064 16.7 2.7 0.073 13.2 0.8 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain Prim_Zn_Ribbon PF08273.12 CDF35312.1 - 0.12 12.6 14.3 3.7 7.9 2.5 4.1 4 0 0 4 4 4 0 Zinc-binding domain of primase-helicase zf-HC5HC2H PF13771.6 CDF35312.1 - 0.55 10.5 6.7 0.61 10.4 3.7 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain HrpJ PF07201.11 CDF35312.1 - 0.77 10.1 9.6 1.7 8.9 9.6 1.5 1 0 0 1 1 1 0 HrpJ-like domain Nop PF01798.18 CDF35313.1 - 1.1e-87 293.3 0.0 2.1e-87 292.4 0.0 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CDF35313.1 - 1e-19 70.7 0.1 4.3e-19 68.7 0.1 2.2 1 0 0 1 1 1 1 NOP5NT (NUC127) domain SBP_bac_3 PF00497.20 CDF35313.1 - 0.005 16.3 0.0 0.0091 15.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 CDC45 PF02724.14 CDF35313.1 - 0.98 7.6 15.9 1.5 7.0 15.9 1.3 1 0 0 1 1 1 0 CDC45-like protein VIR_N PF15912.5 CDF35313.1 - 8.5 5.9 10.5 14 5.2 10.5 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Cyt-b5 PF00173.28 CDF35315.1 - 1.2e-19 70.3 0.0 1.7e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rieske PF00355.26 CDF35316.1 - 2.5e-17 62.6 0.0 4.2e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 CDF35316.1 - 4.5e-11 42.7 0.0 9e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Pheophorbide a oxygenase Fer4 PF00037.27 CDF35317.1 - 4.5e-15 54.7 17.8 5.6e-09 35.4 5.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CDF35317.1 - 6.6e-14 52.2 11.2 1.1e-13 51.6 11.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDF35317.1 - 3.6e-11 43.0 22.6 8.8e-08 32.1 13.2 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDF35317.1 - 5.1e-11 43.3 7.4 2e-05 25.4 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 CDF35317.1 - 3.8e-10 39.8 10.5 6.3e-10 39.1 10.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDF35317.1 - 8.8e-10 38.6 5.2 8.5e-05 22.6 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDF35317.1 - 1.4e-07 31.9 20.5 1.9e-05 25.0 11.6 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDF35317.1 - 1.4e-07 31.3 18.2 0.0002 21.3 5.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDF35317.1 - 7e-07 29.0 12.5 0.0012 18.8 2.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDF35317.1 - 1.7e-05 24.9 12.4 0.0012 19.2 2.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CDF35317.1 - 7.7e-05 23.2 11.9 0.0076 16.8 12.7 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDF35317.1 - 0.001 19.9 18.5 0.0043 17.9 5.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 CDF35317.1 - 0.0011 19.5 12.3 0.067 13.7 1.2 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I c-SKI_SMAD_bind PF08782.10 CDF35317.1 - 0.01 16.1 5.8 0.32 11.3 0.5 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.6 CDF35317.1 - 0.033 14.4 9.9 5.3 7.3 1.7 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 CDF35317.1 - 0.22 11.7 6.3 1.3 9.2 0.5 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 CDF35317.1 - 0.57 11.1 12.6 2.1 9.3 2.1 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain PRP38 PF03371.15 CDF35319.1 - 3.2e-40 137.8 0.0 3.9e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 PRP38 family ANP PF00212.18 CDF35319.1 - 0.2 11.9 0.0 20 5.5 0.0 2.2 2 0 0 2 2 2 0 Atrial natriuretic peptide DUF1015 PF06245.11 CDF35320.1 - 0.019 13.8 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) DUF1129 PF06570.11 CDF35321.1 - 0.12 11.8 0.0 1.6 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) PRP38 PF03371.15 CDF35323.1 - 6.4e-22 78.2 0.0 8e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 PRP38 family ANP PF00212.18 CDF35323.1 - 0.14 12.3 0.7 22 5.3 0.0 2.8 3 0 0 3 3 3 0 Atrial natriuretic peptide PRP38 PF03371.15 CDF35327.1 - 6.4e-22 78.2 0.0 8e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 PRP38 family ANP PF00212.18 CDF35327.1 - 0.14 12.3 0.7 22 5.3 0.0 2.8 3 0 0 3 3 3 0 Atrial natriuretic peptide DUF99 PF01949.16 CDF35328.1 - 0.013 15.0 0.2 0.026 14.0 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function DUF99 YscO-like PF16789.5 CDF35328.1 - 0.29 11.2 3.9 0.12 12.4 1.0 1.8 2 0 0 2 2 2 0 YscO-like protein Ephrin_rec_like PF07699.13 CDF35333.1 - 2.7e-11 43.0 35.3 5.7e-05 22.8 4.9 4.2 1 1 3 4 4 4 4 Putative ephrin-receptor like Trypsin PF00089.26 CDF35333.1 - 0.00019 21.3 0.0 0.00029 20.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin TNFR_c6 PF00020.18 CDF35333.1 - 0.00036 20.9 5.8 0.012 16.0 0.3 5.3 2 2 4 6 6 6 5 TNFR/NGFR cysteine-rich region VSP PF03302.13 CDF35333.1 - 0.0026 16.7 22.7 0.031 13.1 11.6 2.1 1 1 1 2 2 2 2 Giardia variant-specific surface protein DUF2318 PF10080.9 CDF35333.1 - 0.17 12.0 15.0 0.8 9.9 3.2 2.6 1 1 0 2 2 2 0 Predicted membrane protein (DUF2318) Pkinase PF00069.25 CDF35336.1 - 1.1e-51 175.7 0.0 2.2e-51 174.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35336.1 - 3.5e-19 69.1 0.0 4.8e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF35336.1 - 0.0013 18.7 0.2 0.0032 17.4 0.2 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF35336.1 - 0.063 12.9 0.6 0.099 12.2 0.6 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 CDF35336.1 - 0.063 12.9 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 RIO1 family DUF2070 PF09843.9 CDF35338.1 - 0.82 7.9 4.0 0.97 7.6 4.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TMF_TATA_bd PF12325.8 CDF35339.1 - 2.5e-24 85.7 6.5 2.5e-24 85.7 6.5 4.2 2 1 1 3 3 2 1 TATA element modulatory factor 1 TATA binding DUF812 PF05667.11 CDF35339.1 - 1.8e-05 23.9 3.1 1.8e-05 23.9 3.1 3.0 1 1 1 3 3 3 1 Protein of unknown function (DUF812) KASH_CCD PF14662.6 CDF35339.1 - 0.007 16.2 37.3 0.024 14.5 8.0 3.7 2 1 1 3 3 3 2 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.6 CDF35339.1 - 0.011 15.1 1.2 0.011 15.1 1.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 CDF35339.1 - 0.023 15.2 6.4 0.023 15.2 6.4 3.3 2 1 1 3 3 3 0 Fez1 Jnk-SapK_ap_N PF09744.9 CDF35339.1 - 0.093 13.0 40.4 0.3 11.3 13.1 3.8 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 ABC_tran_CTD PF16326.5 CDF35339.1 - 0.14 12.4 48.9 4.6 7.6 2.0 7.2 2 2 5 7 7 7 0 ABC transporter C-terminal domain DUF3584 PF12128.8 CDF35339.1 - 0.17 9.3 38.9 0.48 7.9 28.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) GAS PF13851.6 CDF35339.1 - 0.24 10.7 40.4 0.095 12.0 7.7 3.2 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Csm1_N PF18504.1 CDF35339.1 - 0.66 10.4 30.5 0.89 9.9 0.5 7.0 5 3 2 7 7 7 0 Csm1 N-terminal domain Fzo_mitofusin PF04799.13 CDF35339.1 - 0.7 9.4 19.9 0.28 10.7 6.6 3.7 3 1 1 4 4 4 0 fzo-like conserved region PKcGMP_CC PF16808.5 CDF35339.1 - 0.99 9.3 9.6 10 6.1 1.7 4.6 4 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Allexi_40kDa PF05549.11 CDF35339.1 - 3.6 7.0 8.6 0.56 9.7 1.6 2.7 2 1 1 3 3 3 0 Allexivirus 40kDa protein Spc7 PF08317.11 CDF35339.1 - 4.4 6.1 42.4 0.61 8.9 1.3 3.6 2 2 1 3 3 3 0 Spc7 kinetochore protein NPV_P10 PF05531.12 CDF35339.1 - 5.3 7.6 9.8 50 4.5 0.0 5.1 3 3 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 CDF35339.1 - 5.5 6.8 20.2 10 5.9 4.2 4.4 2 2 2 4 4 4 0 Hepatic lectin, N-terminal domain DUF948 PF06103.11 CDF35339.1 - 5.6 7.3 8.2 8.2 6.8 0.2 3.5 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 CDF35339.1 - 7.2 7.1 33.9 0.096 13.2 2.4 4.8 2 2 1 4 4 4 0 Spectrin repeat BLOC1_2 PF10046.9 CDF35339.1 - 7.3 7.0 23.7 1.3 9.4 0.1 5.0 4 1 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med1 PF10744.9 CDF35340.1 - 1.3e-11 44.2 0.0 2.6e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 PI3_PI4_kinase PF00454.27 CDF35341.1 - 7.9e-59 199.5 0.1 1.8e-58 198.3 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CDF35341.1 - 6.4e-50 170.3 2.4 1e-47 163.1 0.1 2.4 2 0 0 2 2 2 2 FAT domain FRB_dom PF08771.11 CDF35341.1 - 1.6e-25 89.4 3.4 1.6e-25 89.4 3.4 2.6 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain DUF3385 PF11865.8 CDF35341.1 - 2.6e-24 86.0 0.0 2.9e-21 76.1 0.0 4.1 2 2 0 2 2 2 1 Domain of unknown function (DUF3385) FATC PF02260.20 CDF35341.1 - 1.7e-13 50.1 0.4 3.7e-13 49.0 0.4 1.6 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 CDF35341.1 - 1.9e-06 28.2 4.3 0.035 14.5 0.2 5.0 5 0 0 5 5 5 2 HEAT repeats TPR_7 PF13176.6 CDF35341.1 - 0.0018 18.2 1.3 3.9 7.7 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Xpo1 PF08389.12 CDF35341.1 - 0.039 14.0 0.2 40 4.2 0.0 4.0 3 0 0 3 3 3 0 Exportin 1-like protein Reprolysin PF01421.19 CDF35341.1 - 0.065 13.1 0.0 0.97 9.3 0.0 2.3 2 0 0 2 2 2 0 Reprolysin (M12B) family zinc metalloprotease Metallophos PF00149.28 CDF35342.1 - 1.7e-15 58.1 1.3 2.1e-15 57.8 1.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF35342.1 - 8.9e-05 22.7 6.0 0.0013 18.9 6.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Helicase_C PF00271.31 CDF35343.1 - 6.5e-17 61.9 0.0 6e-16 58.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF35343.1 - 2.9e-13 50.0 0.0 3e-12 46.7 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF35343.1 - 2.9e-07 30.6 0.0 7.1e-07 29.4 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 CDF35343.1 - 1.8e-05 25.3 2.3 9.9e-05 23.0 2.3 2.3 1 1 0 1 1 1 1 RecQ zinc-binding DDE_3 PF13358.6 CDF35348.1 - 7.7e-17 61.4 0.0 2.8e-16 59.6 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF35348.1 - 2.2e-08 33.8 0.0 5.4e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF35348.1 - 1.9e-05 24.4 0.0 4.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF35348.1 - 2.4e-05 24.0 0.0 8.4e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CDF35348.1 - 0.043 13.5 0.2 0.56 9.9 0.1 2.4 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.6 CDF35348.1 - 0.07 12.7 0.0 0.24 11.0 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding p450 PF00067.22 CDF35349.1 - 7.5e-68 229.3 0.0 1e-67 228.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CDF35351.1 - 2.7e-72 244.0 0.0 3.3e-72 243.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UQ_con PF00179.26 CDF35352.1 - 1.6e-16 60.2 0.0 1.7e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CDF35352.1 - 0.024 14.5 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 UEV domain Ribosomal_L1 PF00687.21 CDF35353.1 - 2.5e-41 141.7 6.1 2.9e-41 141.5 6.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family CTNNBL PF08216.11 CDF35354.1 - 2.5e-18 66.2 0.0 5e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear DRIM PF07539.12 CDF35354.1 - 0.029 12.7 0.4 0.4 8.9 0.1 2.2 2 0 0 2 2 2 0 Down-regulated in metastasis DUF4704 PF15787.5 CDF35354.1 - 0.037 13.3 0.4 20 4.3 0.1 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4704) DUF913 PF06025.12 CDF35354.1 - 0.066 12.2 0.4 2.7 6.9 0.1 2.4 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) DUF4478 PF14793.6 CDF35354.1 - 0.14 12.1 0.4 2.3 8.1 0.0 2.6 3 0 0 3 3 3 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases GTP_EFTU PF00009.27 CDF35355.1 - 4.1e-50 170.0 0.0 5.7e-50 169.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RF3_C PF16658.5 CDF35355.1 - 5.9e-44 149.1 0.0 9.8e-44 148.3 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDF35355.1 - 5.4e-07 29.7 0.0 1.1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CDF35355.1 - 1e-05 25.8 0.0 2.2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CDF35355.1 - 1.4e-05 25.1 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II TPR_11 PF13414.6 CDF35357.1 - 1.4e-07 31.0 0.5 0.021 14.5 0.0 4.6 3 1 0 3 3 3 2 TPR repeat TPR_17 PF13431.6 CDF35357.1 - 7.1e-07 29.2 1.8 0.04 14.3 0.0 5.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF35357.1 - 1.1e-05 25.8 17.8 0.19 12.3 0.6 6.9 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF35357.1 - 6.9e-05 23.1 24.9 0.064 13.6 0.2 7.9 5 1 3 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF35357.1 - 0.0001 22.9 22.9 0.49 11.1 0.0 7.6 8 1 1 9 9 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDF35357.1 - 0.0013 19.3 22.6 0.17 12.6 0.0 8.3 10 1 0 10 10 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDF35357.1 - 0.002 18.2 22.8 0.65 10.4 0.0 8.8 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF35357.1 - 0.002 18.1 33.5 0.059 13.5 0.1 11.1 13 0 0 13 13 13 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF35357.1 - 0.0032 17.6 0.2 1.9 8.7 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF35357.1 - 0.016 16.0 27.0 3.2 8.8 0.1 9.4 9 2 2 11 11 10 0 Tetratricopeptide repeat ANAPC5 PF12862.7 CDF35357.1 - 0.019 15.1 1.1 0.6 10.2 0.0 3.8 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_1 PF00515.28 CDF35357.1 - 0.067 13.0 17.9 3.7 7.5 0.0 8.4 9 0 0 9 9 9 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF35357.1 - 0.21 11.9 10.9 0.87 9.9 0.3 4.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 CDF35357.1 - 0.21 12.3 11.2 0.89 10.4 0.2 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat DUF4810 PF16068.5 CDF35357.1 - 5.1 7.7 9.9 2.4 8.8 0.0 4.4 4 1 1 5 5 4 0 Domain of unknown function (DUF4810) TPR_10 PF13374.6 CDF35357.1 - 9.8 6.2 17.0 1.3 9.0 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 CDF35358.1 - 2.2e-38 132.4 0.0 2.4e-38 132.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II AP_endonuc_2 PF01261.24 CDF35358.1 - 0.097 12.1 0.0 0.53 9.7 0.0 1.9 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel DUF4604 PF15377.6 CDF35360.1 - 0.00084 19.8 2.1 0.0011 19.4 2.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Tmemb_161AB PF10268.9 CDF35361.1 - 1.4e-10 40.5 11.1 2.7e-09 36.2 1.9 3.0 1 1 1 2 2 2 2 Predicted transmembrane protein 161AB MS_channel PF00924.18 CDF35362.1 - 1.6e-39 135.6 0.0 2.3e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel Ketoacyl-synt_C PF02801.22 CDF35364.1 - 3.7e-32 110.8 1.0 5.1e-32 110.4 1.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CDF35364.1 - 2.6e-29 102.6 0.7 2.6e-29 102.6 0.7 2.3 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CDF35364.1 - 0.00085 18.8 0.3 0.0059 16.0 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 CDF35364.1 - 0.028 14.9 0.1 0.069 13.6 0.1 1.7 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension GST_C_2 PF13410.6 CDF35365.1 - 4.4e-12 45.9 0.3 6.8e-12 45.2 0.3 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CDF35365.1 - 3.4e-10 40.1 0.0 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDF35365.1 - 0.0079 16.4 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDF35365.1 - 0.0082 16.5 0.0 0.029 14.8 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain DUF4916 PF16262.5 CDF35366.1 - 0.0045 16.5 0.0 0.0084 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4916) HIP1_clath_bdg PF16515.5 CDF35366.1 - 0.14 12.7 1.1 0.28 11.8 1.1 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RVT_1 PF00078.27 CDF35367.1 - 2.3e-08 33.9 0.0 3.7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AbiEi_4 PF13338.6 CDF35367.1 - 0.076 13.2 0.3 0.39 10.9 0.2 2.3 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin Orn_DAP_Arg_deC PF00278.22 CDF35368.1 - 0.034 14.4 0.0 0.048 13.9 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain tRNA_synthFbeta PF17759.1 CDF35369.1 - 2.6e-47 161.0 0.0 4.8e-47 160.2 0.0 1.5 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 CDF35369.1 - 3.2e-33 113.8 0.1 1.9e-32 111.3 0.0 2.2 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 CDF35369.1 - 3.9e-25 88.5 0.0 1.4e-24 86.7 0.0 2.0 2 0 0 2 2 2 1 B3/4 domain B5 PF03484.15 CDF35369.1 - 1.3e-15 57.4 0.0 2.9e-12 46.7 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain Spermine_synth PF01564.17 CDF35370.1 - 0.00014 21.3 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_11 PF08241.12 CDF35370.1 - 0.033 14.8 0.0 0.076 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDF35370.1 - 0.05 13.4 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_6 PF13480.7 CDF35372.1 - 0.025 14.7 0.1 0.025 14.7 0.1 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CobN-Mg_chel PF02514.16 CDF35374.1 - 0.048 11.4 0.0 0.051 11.3 0.0 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase Coprogen_oxidas PF01218.18 CDF35375.1 - 0.0051 15.6 0.0 0.006 15.3 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Rotamase_3 PF13616.6 CDF35376.1 - 1.4e-18 67.5 0.0 3.1e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 CDF35376.1 - 9.6e-18 64.9 0.0 1.9e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rhodanese PF00581.20 CDF35376.1 - 5.8e-09 36.4 0.0 9.7e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Rotamase_2 PF13145.6 CDF35376.1 - 5.5e-06 27.2 0.0 8.9e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain SNF2_N PF00176.23 CDF35377.1 - 9.4e-36 123.2 0.0 1.6e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF35377.1 - 6.7e-14 52.2 0.0 3.4e-13 49.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF35377.1 - 7.3e-06 26.1 0.0 6.2e-05 23.1 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDF35377.1 - 0.0065 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase RVT_3 PF13456.6 CDF35378.1 - 0.023 14.5 0.4 0.12 12.1 0.4 2.0 1 1 0 1 1 1 0 Reverse transcriptase-like AAA PF00004.29 CDF35379.1 - 1.5e-76 255.2 0.0 1.1e-42 145.6 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF35379.1 - 1.5e-18 66.3 10.5 7.3e-12 44.9 1.0 3.5 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 CDF35379.1 - 7e-13 49.3 5.3 0.0057 17.0 0.0 5.6 2 2 2 5 5 5 3 AAA ATPase domain AAA_5 PF07728.14 CDF35379.1 - 6.4e-10 39.2 0.1 0.0022 18.0 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDF35379.1 - 1.1e-09 38.7 0.0 0.0025 18.0 0.0 2.6 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDF35379.1 - 1e-08 35.1 0.0 0.0054 16.5 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CDF35379.1 - 1.5e-08 34.6 0.0 6.6e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 CDF35379.1 - 4.3e-07 30.3 0.6 0.6 10.4 0.0 4.6 3 1 1 4 4 4 2 AAA domain TIP49 PF06068.13 CDF35379.1 - 7e-07 28.8 0.0 0.0091 15.2 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 CDF35379.1 - 2.7e-05 23.6 0.2 0.11 11.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CDF35379.1 - 0.00044 20.3 0.0 0.24 11.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 CDF35379.1 - 0.00051 19.9 0.0 0.99 9.3 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDF35379.1 - 0.00065 19.9 0.0 0.42 10.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDF35379.1 - 0.00092 19.8 0.0 0.46 11.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain CDC48_N PF02359.18 CDF35379.1 - 0.0012 19.0 0.0 0.0029 17.7 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RNA_helicase PF00910.22 CDF35379.1 - 0.0015 18.9 0.0 1.4 9.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 CDF35379.1 - 0.0015 18.5 0.2 0.88 9.5 0.2 3.9 2 2 2 4 4 4 1 NACHT domain Sigma54_activat PF00158.26 CDF35379.1 - 0.0047 16.6 0.0 1.4 8.6 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 CDF35379.1 - 0.0073 15.9 7.6 0.25 10.9 0.0 4.2 3 1 2 5 5 5 1 AAA domain AAA_28 PF13521.6 CDF35379.1 - 0.0081 16.4 0.0 6.6 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 CDF35379.1 - 0.0081 15.6 0.0 0.62 9.5 0.0 2.8 3 0 0 3 3 3 1 PhoH-like protein CDC48_2 PF02933.17 CDF35379.1 - 0.011 15.6 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 AAA_11 PF13086.6 CDF35379.1 - 0.014 15.2 0.0 1.2 8.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CDF35379.1 - 0.019 14.7 0.1 0.22 11.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDF35379.1 - 0.021 14.3 0.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 CDF35379.1 - 0.023 15.2 0.2 11 6.5 0.0 3.7 3 1 0 4 4 4 0 ABC transporter Rad17 PF03215.15 CDF35379.1 - 0.027 14.4 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 CDF35379.1 - 0.031 14.3 0.0 6 6.9 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CDF35379.1 - 0.035 14.0 0.1 81 3.0 0.1 3.9 2 2 1 4 4 4 0 ATPase domain predominantly from Archaea ATPase PF06745.13 CDF35379.1 - 0.056 12.8 0.0 2.8 7.2 0.0 2.5 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.6 CDF35379.1 - 0.074 12.8 0.0 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF35379.1 - 0.15 11.2 0.0 5.5 6.1 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain Sigma54_activ_2 PF14532.6 CDF35379.1 - 0.15 12.2 0.0 7.2 6.7 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Ribosomal_L7Ae PF01248.26 CDF35380.1 - 7.8e-26 89.7 0.1 9.2e-26 89.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CDF35380.1 - 0.00086 19.1 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 CDF35380.1 - 0.005 16.9 0.0 0.0051 16.9 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Adenosine_kin PF04008.14 CDF35380.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Adenosine specific kinase 2Fe-2S_thioredx PF01257.19 CDF35381.1 - 0.033 14.1 0.1 0.063 13.1 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin RRM_1 PF00076.22 CDF35382.1 - 2e-54 181.3 0.1 1.6e-15 56.7 0.0 6.8 5 1 1 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CRAL_TRIO PF00650.20 CDF35383.1 - 3.9e-18 65.7 0.0 6.7e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CDF35383.1 - 4e-05 23.7 0.0 6.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Rad51 PF08423.11 CDF35384.1 - 2.4e-121 403.8 0.0 3.1e-121 403.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 CDF35384.1 - 1.2e-13 51.1 0.0 1.8e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 CDF35384.1 - 2.6e-12 46.7 0.1 4.1e-12 46.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CDF35384.1 - 1.3e-07 31.2 0.1 3.1e-07 30.0 0.0 1.8 2 1 0 2 2 2 1 KaiC HHH_5 PF14520.6 CDF35384.1 - 6.2e-07 29.9 1.0 1.6e-06 28.6 1.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DnaB_C PF03796.15 CDF35384.1 - 0.00097 18.5 0.0 0.044 13.1 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 CDF35384.1 - 0.0071 16.6 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain PAXNEB PF05625.11 CDF35384.1 - 0.016 14.4 1.0 0.13 11.4 0.6 2.1 1 1 1 2 2 2 0 PAXNEB protein AAA_24 PF13479.6 CDF35384.1 - 0.035 13.8 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Prefoldin PF02996.17 CDF35385.1 - 3.4e-21 75.4 1.5 4.3e-21 75.0 1.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit Syntaxin-6_N PF09177.11 CDF35385.1 - 0.048 14.2 2.5 0.15 12.6 0.0 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF2218 PF09981.9 CDF35385.1 - 0.14 12.5 2.8 0.38 11.2 1.0 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2218) HAUS-augmin3 PF14932.6 CDF35385.1 - 0.27 10.8 8.4 1 8.9 0.1 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4570 PF15134.6 CDF35385.1 - 1 9.4 7.6 0.18 11.8 3.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Spc24 PF08286.11 CDF35385.1 - 4.8 7.5 9.3 5.8 7.2 0.2 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 RRF PF01765.19 CDF35386.1 - 5.1e-44 150.1 0.3 7.1e-44 149.6 0.3 1.2 1 0 0 1 1 1 1 Ribosome recycling factor NICE-3 PF07406.11 CDF35386.1 - 0.083 12.9 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 NICE-3 protein Ku_PK_bind PF08785.11 CDF35386.1 - 0.1 12.7 0.2 17 5.6 0.0 2.3 2 0 0 2 2 2 0 Ku C terminal domain like Vps4_C PF09336.10 CDF35386.1 - 0.13 12.3 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Semialdhyde_dh PF01118.24 CDF35387.1 - 1.6e-28 99.5 0.0 3.7e-28 98.4 0.0 1.6 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 CDF35387.1 - 1.6e-19 70.7 0.0 2.5e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain F420_oxidored PF03807.17 CDF35387.1 - 0.025 15.2 0.0 0.053 14.1 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 CDF35387.1 - 0.04 14.0 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 CDF35387.1 - 0.062 13.6 0.0 0.11 12.7 0.0 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DNA_pol_phi PF04931.13 CDF35388.1 - 2.9e-07 29.0 9.9 1.3e-06 26.9 9.9 2.0 1 1 0 1 1 1 1 DNA polymerase phi STAG PF08514.11 CDF35389.1 - 1.4e-16 60.4 0.1 1.4e-16 60.4 0.1 3.2 3 0 0 3 3 3 1 STAG domain Cnd1 PF12717.7 CDF35389.1 - 5.7e-06 26.5 0.7 0.00012 22.1 0.1 2.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDF35389.1 - 1.5e-05 25.3 1.2 0.15 12.4 0.0 4.4 4 1 1 5 5 5 2 HEAT repeats RTP1_C1 PF10363.9 CDF35389.1 - 0.0032 17.6 0.1 0.029 14.5 0.0 2.5 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 CDF35389.1 - 0.005 17.0 4.5 5.6 7.5 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat DUF4042 PF13251.6 CDF35389.1 - 0.044 13.5 0.4 2.6 7.7 0.0 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4042) Ipi1_N PF12333.8 CDF35389.1 - 1.1 9.9 6.1 20 5.9 0.0 5.2 5 0 0 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation RPA_interact_C PF14768.6 CDF35390.1 - 1.3e-16 60.9 4.7 1.3e-16 60.9 4.7 1.8 2 1 0 2 2 2 1 Replication protein A interacting C-terminal RPA_interact_N PF14766.6 CDF35390.1 - 0.22 11.2 7.9 0.087 12.5 4.6 2.2 2 0 0 2 2 2 0 Replication protein A interacting N-terminal DUF1840 PF08895.11 CDF35390.1 - 0.82 10.0 4.0 0.95 9.8 2.9 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) Histone_HNS PF00816.21 CDF35390.1 - 2 9.3 4.5 0.51 11.2 0.6 1.9 2 0 0 2 2 2 0 H-NS histone family DUF2451 PF10474.9 CDF35392.1 - 1.4e-13 51.2 0.0 4e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 CDF35392.1 - 3.1e-05 23.4 0.2 5.2e-05 22.7 0.2 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex TIMELESS PF04821.14 CDF35393.1 - 4e-17 62.4 1.1 1.2e-16 60.8 0.0 2.4 3 1 0 3 3 3 1 Timeless protein DUF2688 PF10892.8 CDF35393.1 - 0.069 12.6 0.1 0.16 11.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) Fungal_trans_2 PF11951.8 CDF35393.1 - 0.11 11.3 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain PPTA PF01239.22 CDF35394.1 - 2.5e-30 103.3 11.8 1.3e-08 34.3 0.3 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat MATH PF00917.26 CDF35394.1 - 0.11 12.7 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 MATH domain DUF4219 PF13961.6 CDF35394.1 - 0.7 9.6 4.9 3.7 7.3 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) Sin_N PF04801.13 CDF35395.1 - 4.4e-60 204.1 0.0 5.4e-60 203.8 0.0 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region p450 PF00067.22 CDF35397.1 - 7e-83 278.9 0.0 9.1e-83 278.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF647 PF04884.14 CDF35398.1 - 3.9e-59 200.2 0.1 5.8e-59 199.6 0.1 1.3 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DNA_photolyase PF00875.18 CDF35398.1 - 0.004 17.2 0.1 0.0081 16.2 0.1 1.5 1 0 0 1 1 1 1 DNA photolyase HEAT_2 PF13646.6 CDF35399.1 - 5.7e-16 58.7 9.6 6.7e-06 26.4 0.0 5.4 4 2 1 5 5 5 4 HEAT repeats Arm PF00514.23 CDF35399.1 - 0.0024 17.8 0.0 0.65 10.1 0.0 2.9 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CDF35399.1 - 0.012 15.8 3.2 23 5.6 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat HEAT_PBS PF03130.16 CDF35399.1 - 0.014 16.0 10.5 0.81 10.5 0.1 6.3 7 1 0 7 7 7 0 PBS lyase HEAT-like repeat Kelch_4 PF13418.6 CDF35400.1 - 4.8e-23 80.9 11.4 5e-07 29.6 0.0 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 CDF35400.1 - 4.1e-19 68.2 8.8 0.0006 20.0 0.0 6.1 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 CDF35400.1 - 7.5e-19 67.5 13.6 1.3e-06 28.6 0.1 6.1 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 CDF35400.1 - 6.8e-13 48.0 5.8 0.022 14.3 0.0 5.8 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 CDF35400.1 - 5e-12 45.5 3.3 0.033 14.2 0.0 4.7 4 0 0 4 4 4 3 Kelch motif zf-C3HC4_3 PF13920.6 CDF35400.1 - 5.1e-12 45.4 9.5 8.3e-12 44.8 9.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Kelch_2 PF07646.15 CDF35400.1 - 9.1e-08 31.8 11.1 0.097 12.7 0.0 6.0 6 0 0 6 6 6 3 Kelch motif zf-C3HC4 PF00097.25 CDF35400.1 - 0.037 13.9 9.6 0.068 13.1 9.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF35400.1 - 0.065 13.1 10.6 0.12 12.3 10.6 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CDF35400.1 - 0.33 10.9 10.3 0.56 10.2 10.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDF35400.1 - 0.47 10.5 6.7 8.6 6.5 4.1 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDF35400.1 - 0.66 9.9 11.0 1.2 9.0 11.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CDF35400.1 - 4.1 7.3 8.5 7.5 6.4 8.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Ras PF00071.22 CDF35401.1 - 1.9e-55 186.9 0.7 2.3e-55 186.6 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF35401.1 - 9.1e-33 113.0 0.3 1.4e-32 112.4 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF35401.1 - 6.7e-21 74.5 0.2 7.9e-21 74.3 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDF35401.1 - 7.4e-07 29.3 0.0 1e-06 28.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF35401.1 - 9.3e-07 28.4 0.2 1.2e-06 28.1 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDF35401.1 - 9.9e-05 21.8 0.2 0.00045 19.7 0.0 1.9 1 1 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDF35401.1 - 0.00019 21.0 0.4 0.00057 19.5 0.3 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDF35401.1 - 0.00088 19.2 0.5 0.054 13.4 0.1 2.5 1 1 2 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 CDF35401.1 - 0.003 17.9 0.2 0.0099 16.3 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CDF35401.1 - 0.005 17.4 0.0 0.014 15.9 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CDF35401.1 - 0.016 14.9 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 CDF35401.1 - 0.019 14.2 1.5 2.8 7.0 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit MCM PF00493.23 CDF35401.1 - 0.021 13.9 0.1 0.096 11.8 0.0 1.8 1 1 0 2 2 2 0 MCM P-loop domain AAA_7 PF12775.7 CDF35401.1 - 0.025 14.1 0.1 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 CDF35401.1 - 0.034 13.9 0.1 0.042 13.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CDF35401.1 - 0.04 13.3 0.0 0.074 12.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 CDF35401.1 - 0.046 14.0 0.0 0.25 11.6 0.0 1.9 1 1 0 2 2 2 0 AAA domain CPT PF07931.12 CDF35401.1 - 0.051 13.4 0.1 0.081 12.8 0.1 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.6 CDF35401.1 - 0.055 13.0 0.1 0.11 12.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain AIG1 PF04548.16 CDF35401.1 - 0.15 11.4 0.7 0.66 9.3 0.1 2.2 1 1 1 2 2 2 0 AIG1 family Epimerase PF01370.21 CDF35402.1 - 1e-25 90.6 0.0 2.6e-25 89.3 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDF35402.1 - 5.3e-20 72.1 0.0 1.5e-19 70.6 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDF35402.1 - 0.00031 20.0 0.0 0.49 9.5 0.0 2.3 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein UDPG_MGDP_dh_N PF03721.14 CDF35402.1 - 0.005 16.4 0.0 0.0091 15.6 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3Beta_HSD PF01073.19 CDF35402.1 - 0.021 13.9 0.0 0.044 12.8 0.0 1.6 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family SF1-HH PF16275.5 CDF35403.1 - 1.1e-18 67.6 0.4 3.3e-18 66.1 0.4 1.9 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 CDF35403.1 - 3.8e-05 23.4 1.2 7e-05 22.6 1.1 1.5 1 1 0 1 1 1 1 KH domain Formyl_trans_N PF00551.19 CDF35404.1 - 2.6e-33 115.3 0.0 3.5e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 CDF35404.1 - 6e-18 64.9 0.0 1.6e-17 63.5 0.0 1.8 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DUF3748 PF12566.8 CDF35404.1 - 0.12 12.3 0.0 13 5.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3748) Ebp2 PF05890.12 CDF35405.1 - 8.4e-36 123.9 16.7 1e-35 123.6 16.7 1.1 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 eIF3_N PF09440.10 CDF35407.1 - 7e-35 120.4 1.7 1.4e-34 119.4 0.9 2.0 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 CDF35407.1 - 9.5e-18 64.6 2.9 1.4e-17 64.2 0.1 2.4 3 0 0 3 3 3 1 PCI domain SopA PF13981.6 CDF35407.1 - 0.03 14.8 0.9 0.059 13.8 0.9 1.4 1 0 0 1 1 1 0 SopA-like central domain HisK_N PF09385.10 CDF35407.1 - 0.082 12.9 0.3 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase N terminal PCNA_N PF00705.18 CDF35408.1 - 2.3e-47 159.8 1.9 4.1e-47 159.1 1.9 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 CDF35408.1 - 5.9e-34 117.0 0.0 1.5e-33 115.7 0.0 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 CDF35408.1 - 2.6e-07 30.0 0.3 1.5e-05 24.2 0.3 2.2 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 CDF35408.1 - 0.044 12.9 0.0 2.1 7.4 0.0 2.8 1 1 0 1 1 1 0 Hus1-like protein Rad9 PF04139.13 CDF35408.1 - 0.047 13.1 0.1 0.075 12.5 0.1 1.4 1 1 0 1 1 1 0 Rad9 YukD PF08817.10 CDF35408.1 - 0.066 13.9 0.0 0.17 12.6 0.0 1.7 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD ELMO_CED12 PF04727.13 CDF35409.1 - 8.3e-36 123.7 0.0 1.2e-35 123.3 0.0 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family ACR_tran PF00873.19 CDF35409.1 - 0.17 9.5 0.1 0.21 9.2 0.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family RNase_PH PF01138.21 CDF35410.1 - 6e-21 75.3 0.0 2.5e-20 73.3 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF35410.1 - 3.6e-07 30.1 0.1 6.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Histone PF00125.24 CDF35412.1 - 2.1e-19 70.2 0.3 2.5e-19 69.9 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CDF35412.1 - 1.3e-10 40.9 0.9 4.5e-10 39.1 0.0 2.2 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CDF35412.1 - 0.0018 18.5 0.0 0.0029 17.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RRM_1 PF00076.22 CDF35413.1 - 1.2e-24 85.9 0.0 1.8e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 CDF35413.1 - 1.9e-09 37.8 0.7 3.9e-09 36.8 0.7 1.6 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 DNA_ligase_IV PF11411.8 CDF35413.1 - 0.017 15.2 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 DNA ligase IV DUF4154 PF13689.6 CDF35413.1 - 0.047 13.9 0.0 0.071 13.3 0.0 1.2 1 0 0 1 1 1 0 YfiR/HmsC-like RRM_7 PF16367.5 CDF35413.1 - 0.11 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif ORC_WH_C PF18137.1 CDF35414.1 - 5.8e-19 68.5 0.0 3.2e-17 62.9 0.0 2.6 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 CDF35414.1 - 1.3e-07 31.1 0.2 9.8e-06 24.9 0.0 3.4 2 1 1 3 3 3 1 Origin recognition complex (ORC) subunit 3 N-terminus Cdc6_C PF09079.11 CDF35414.1 - 0.084 12.9 0.0 0.37 10.8 0.0 2.1 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Prominin PF05478.11 CDF35414.1 - 0.38 8.7 0.7 0.56 8.1 0.7 1.1 1 0 0 1 1 1 0 Prominin FabA PF07977.13 CDF35415.1 - 1e-34 119.1 0.0 1.4e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydratas PF01575.19 CDF35415.1 - 0.049 13.2 0.0 0.098 12.2 0.0 1.5 1 0 0 1 1 1 0 MaoC like domain SIP1 PF04938.12 CDF35416.1 - 8e-19 68.2 0.0 9.7e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) PhyH PF05721.13 CDF35417.1 - 1e-41 143.6 0.1 1.2e-41 143.3 0.1 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 CDF35417.1 - 0.005 17.2 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Vta1 PF04652.16 CDF35418.1 - 4e-37 127.4 0.1 6.7e-37 126.7 0.1 1.4 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 CDF35418.1 - 6.2e-15 54.6 1.0 1.4e-14 53.5 1.0 1.6 1 0 0 1 1 1 1 Vta1 C-terminal domain PDT PF00800.18 CDF35420.1 - 2.6e-57 193.6 0.0 3.7e-57 193.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 CDF35420.1 - 0.045 13.5 0.0 0.17 11.7 0.0 2.0 1 1 0 1 1 1 0 ACT domain ERG4_ERG24 PF01222.17 CDF35421.1 - 6.3e-86 288.8 12.2 7.4e-86 288.6 12.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CDF35421.1 - 7.3e-05 22.4 2.1 7.3e-05 22.4 2.1 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) DUF5392 PF17370.2 CDF35421.1 - 0.021 14.9 0.0 0.23 11.6 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5392) ICMT PF04140.14 CDF35421.1 - 1 9.8 5.6 2.3 8.7 0.0 3.1 3 0 0 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family CLTH PF10607.9 CDF35423.1 - 1.1e-23 83.8 0.0 1.5e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 CDF35423.1 - 4.5e-06 26.6 1.6 6.3e-06 26.1 0.2 2.0 2 0 0 2 2 2 1 RING-type zinc-finger Rtf2 PF04641.12 CDF35423.1 - 0.0022 17.4 0.2 0.0039 16.6 0.2 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.6 CDF35423.1 - 0.0076 16.6 0.3 0.019 15.3 0.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF35423.1 - 0.037 13.9 0.3 0.074 12.9 0.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDF35423.1 - 0.045 13.9 0.2 0.12 12.5 0.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CDF35423.1 - 0.059 13.3 0.3 0.12 12.4 0.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDF35423.1 - 0.11 12.3 0.7 0.27 11.1 0.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pellino PF04710.14 CDF35423.1 - 0.13 10.9 0.4 0.2 10.3 0.4 1.2 1 0 0 1 1 1 0 Pellino TPR_14 PF13428.6 CDF35423.1 - 1.9 9.5 5.4 4.5 8.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat LON_substr_bdg PF02190.16 CDF35424.1 - 1.3e-20 74.2 0.0 4e-20 72.6 0.0 1.7 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain EF-hand_13 PF17958.1 CDF35427.1 - 1.9e-23 82.1 0.0 4.3e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 CDF35427.1 - 2.6e-18 66.2 4.4 8.8e-18 64.5 0.7 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 CDF35427.1 - 0.00052 19.4 0.3 0.0063 16.0 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 CDF35427.1 - 0.0082 15.6 0.7 0.43 10.2 0.3 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 CDF35427.1 - 0.031 14.1 1.3 0.13 12.2 0.4 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 CDF35427.1 - 0.56 10.3 2.0 5 7.3 0.1 3.0 3 0 0 3 3 3 0 EF-hand domain RT_RNaseH PF17917.1 CDF35428.1 - 1.9e-18 66.7 0.0 4.6e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF35428.1 - 1e-13 51.1 0.3 2.3e-13 50.0 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF35428.1 - 6e-11 42.6 0.0 1.3e-10 41.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDF35428.1 - 2.1e-08 34.1 0.0 5.1e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 CDF35428.1 - 4e-06 27.3 0.0 9.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease PWWP PF00855.17 CDF35428.1 - 3.5e-05 24.1 0.1 0.00012 22.4 0.1 1.9 1 0 0 1 1 1 1 PWWP domain zf-H2C2 PF09337.10 CDF35428.1 - 6.3e-05 23.1 0.5 6.3e-05 23.1 0.5 2.2 2 0 0 2 2 2 1 H2C2 zinc finger Asp_protease_2 PF13650.6 CDF35428.1 - 0.0011 19.5 0.0 0.0025 18.4 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 CDF35428.1 - 0.0026 17.6 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Chromo PF00385.24 CDF35428.1 - 0.008 16.1 1.8 0.019 14.9 1.8 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVP_2 PF08284.11 CDF35428.1 - 0.011 15.6 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.27 CDF35428.1 - 0.021 14.3 0.4 7.6 6.0 0.0 3.3 1 1 2 3 3 3 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3194 PF11419.8 CDF35428.1 - 0.089 13.2 0.2 0.22 11.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) TTD PF12148.8 CDF35428.1 - 0.24 11.3 2.3 1.4 8.8 2.3 2.1 1 1 0 1 1 1 0 Tandem tudor domain within UHRF1 CNOT11 PF10155.9 CDF35429.1 - 0.011 15.9 0.4 0.073 13.2 0.4 2.5 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 AAA_12 PF13087.6 CDF35430.1 - 1.9e-57 194.1 0.0 3.2e-57 193.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDF35430.1 - 1.8e-54 185.3 7.7 1.2e-28 100.6 0.0 3.5 3 1 1 4 4 4 2 AAA domain AAA_30 PF13604.6 CDF35430.1 - 6.2e-09 35.8 0.0 2.6e-07 30.5 0.0 2.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDF35430.1 - 3.3e-07 30.3 0.0 0.28 10.9 0.0 3.6 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CDF35430.1 - 7.2e-07 29.6 0.0 7.7e-06 26.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDF35430.1 - 0.015 15.6 0.0 0.062 13.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 CDF35430.1 - 0.036 13.6 0.2 2.7 7.4 0.0 2.6 2 1 0 3 3 3 0 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 CDF35430.1 - 0.045 13.6 0.0 0.21 11.4 0.0 2.2 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 CDF35430.1 - 0.066 12.4 0.0 0.066 12.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AvrPto PF11592.8 CDF35431.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Central core of the bacterial effector protein AvrPto Aminotran_1_2 PF00155.21 CDF35434.1 - 2.2e-86 290.3 0.0 2.5e-86 290.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II THF_DHG_CYH_C PF02882.19 CDF35435.1 - 3.6e-70 234.4 0.4 3.6e-70 234.4 0.4 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CDF35435.1 - 4.3e-37 126.9 0.0 6.3e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain RRM_3 PF08777.11 CDF35438.1 - 3.5e-27 94.4 0.0 3.3e-16 59.2 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif RRM_1 PF00076.22 CDF35438.1 - 3e-12 46.2 0.0 4.8e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) La PF05383.17 CDF35438.1 - 0.053 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 La domain CT_A_B PF02626.15 CDF35439.1 - 8.7e-76 255.0 0.0 1.6e-75 254.2 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 CDF35439.1 - 7.8e-56 188.9 0.1 2.3e-55 187.4 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 CDF35439.1 - 3.8e-43 147.6 0.0 7.7e-43 146.6 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Amidase PF01425.21 CDF35439.1 - 4.7e-35 121.4 0.7 6.8e-35 120.9 0.7 1.2 1 0 0 1 1 1 1 Amidase Biotin_carb_N PF00289.22 CDF35439.1 - 1e-28 100.0 0.0 2.4e-28 98.9 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDF35439.1 - 8.1e-28 96.7 0.0 2e-27 95.4 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDF35439.1 - 2.4e-14 52.9 0.1 5.2e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDF35439.1 - 4.6e-09 35.9 0.1 1.5e-06 27.9 0.0 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.6 CDF35439.1 - 0.00061 19.7 0.1 0.0017 18.3 0.1 1.7 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Dala_Dala_lig_C PF07478.13 CDF35439.1 - 0.0011 18.6 0.0 0.0025 17.4 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus HlyD_D23 PF16576.5 CDF35439.1 - 0.0013 18.0 0.0 0.59 9.3 0.0 2.3 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion NQRA PF05896.11 CDF35439.1 - 0.0084 15.6 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATP-grasp PF02222.22 CDF35439.1 - 0.01 15.4 0.0 0.025 14.2 0.0 1.6 2 0 0 2 2 2 0 ATP-grasp domain NEXCaM_BD PF16644.5 CDF35439.1 - 0.074 13.3 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin GCV_H PF01597.19 CDF35439.1 - 0.085 12.7 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein Homeodomain PF00046.29 CDF35440.1 - 0.046 13.6 0.8 0.09 12.6 0.8 1.5 1 0 0 1 1 1 0 Homeodomain Glutaredoxin PF00462.24 CDF35444.1 - 1.1e-17 64.0 0.0 2e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 CDF35444.1 - 0.00016 21.6 0.0 0.0003 20.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin domain GST_N_2 PF13409.6 CDF35444.1 - 0.0012 19.1 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDF35444.1 - 0.0017 18.8 0.0 0.0026 18.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 CDF35444.1 - 0.11 13.0 0.0 0.41 11.1 0.0 1.9 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DUF3510 PF12022.8 CDF35445.1 - 3.3e-26 92.1 0.2 3.7e-25 88.8 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) COG2 PF06148.11 CDF35445.1 - 4e-17 62.5 0.0 9.4e-17 61.3 0.0 1.7 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin-6_N PF09177.11 CDF35445.1 - 0.05 14.1 0.4 2.3 8.8 0.0 3.2 2 1 1 3 3 3 0 Syntaxin 6, N-terminal WD40 PF00400.32 CDF35446.1 - 0.00021 22.0 0.5 2.3 9.2 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat PQQ_3 PF13570.6 CDF35446.1 - 0.046 14.2 0.0 58 4.4 0.0 3.3 3 0 0 3 3 3 0 PQQ-like domain SBP56 PF05694.11 CDF35446.1 - 0.13 11.1 0.0 0.36 9.6 0.0 1.6 1 1 1 2 2 2 0 56kDa selenium binding protein (SBP56) PAP2 PF01569.21 CDF35449.1 - 0.0015 18.3 3.5 0.0015 18.3 3.5 2.8 2 1 1 3 3 3 1 PAP2 superfamily Tho2 PF11262.8 CDF35450.1 - 7.4e-54 183.0 0.0 1.1e-53 182.4 0.0 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 CDF35450.1 - 3.5e-40 138.3 0.1 1.6e-21 76.7 0.0 2.7 2 1 0 2 2 2 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 CDF35450.1 - 1.3e-11 44.4 0.0 2.6e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Amidase PF01425.21 CDF35451.1 - 2.5e-72 244.3 0.3 3.3e-72 243.9 0.3 1.2 1 0 0 1 1 1 1 Amidase AAA PF00004.29 CDF35452.1 - 8.1e-95 314.3 0.0 6.6e-47 159.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF35452.1 - 1.2e-24 85.8 12.8 5.1e-14 51.8 0.5 3.2 3 1 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 CDF35452.1 - 3.4e-21 75.2 0.3 8.7e-21 73.9 0.3 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 CDF35452.1 - 5.2e-14 52.3 0.0 1.5e-05 24.8 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF35452.1 - 1e-12 48.8 0.3 0.00038 20.9 0.0 4.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 CDF35452.1 - 3.2e-12 46.9 0.0 6.4e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDF35452.1 - 8.9e-12 45.4 0.0 1.4e-05 25.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 CDF35452.1 - 2e-11 43.5 0.0 4e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.14 CDF35452.1 - 5.4e-11 42.7 0.1 1e-05 25.6 0.0 3.4 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDF35452.1 - 1e-08 34.8 0.0 0.0013 18.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 CDF35452.1 - 1.4e-08 35.1 0.2 0.068 13.4 0.0 3.9 2 2 1 3 3 2 2 AAA domain Mg_chelatase PF01078.21 CDF35452.1 - 2.7e-07 30.2 0.3 0.028 13.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CDF35452.1 - 6.4e-07 29.5 0.0 0.02 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDF35452.1 - 8.4e-07 29.6 0.0 0.031 14.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDF35452.1 - 3.5e-06 27.4 0.0 0.038 14.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase ATPase_2 PF01637.18 CDF35452.1 - 6.7e-06 26.2 0.1 0.55 10.1 0.1 3.5 3 1 0 3 3 2 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDF35452.1 - 6.7e-06 25.9 0.0 0.061 13.0 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_17 PF13207.6 CDF35452.1 - 9.8e-06 26.0 0.0 0.17 12.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 CDF35452.1 - 1.7e-05 24.7 0.2 0.00023 21.1 0.1 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_25 PF13481.6 CDF35452.1 - 2.2e-05 24.2 2.6 0.92 9.0 0.0 4.5 3 2 1 5 5 5 1 AAA domain Bac_DnaA PF00308.18 CDF35452.1 - 2.3e-05 24.4 0.0 0.063 13.1 0.0 2.6 2 0 0 2 2 2 2 Bacterial dnaA protein Viral_helicase1 PF01443.18 CDF35452.1 - 2.5e-05 24.2 0.0 0.0086 15.8 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 CDF35452.1 - 2.6e-05 24.0 0.0 0.23 11.2 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 CDF35452.1 - 5e-05 22.9 0.0 0.14 11.6 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 CDF35452.1 - 5.4e-05 23.2 0.1 0.34 10.8 0.0 3.5 3 1 1 4 4 3 1 NACHT domain Parvo_NS1 PF01057.17 CDF35452.1 - 6.4e-05 22.2 0.0 0.069 12.2 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 CDF35452.1 - 6.9e-05 22.7 0.1 0.35 10.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 CDF35452.1 - 7.1e-05 23.3 0.0 0.099 13.2 0.0 2.7 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 CDF35452.1 - 7.8e-05 22.0 0.0 0.41 9.9 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin TsaE PF02367.17 CDF35452.1 - 8.4e-05 22.6 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 CDF35452.1 - 0.00012 21.5 1.3 3.4 6.9 0.0 3.6 4 0 0 4 4 3 0 KaiC AAA_28 PF13521.6 CDF35452.1 - 0.00013 22.2 0.2 0.45 10.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain DUF2075 PF09848.9 CDF35452.1 - 0.00018 20.9 0.0 0.48 9.6 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 CDF35452.1 - 0.00039 20.5 0.0 0.44 10.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 CDF35452.1 - 0.0005 19.3 0.0 0.47 9.6 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ResIII PF04851.15 CDF35452.1 - 0.00098 19.2 0.0 0.32 11.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 CDF35452.1 - 0.0016 18.0 0.2 1.8 7.9 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.11 CDF35452.1 - 0.0028 17.5 0.0 3.3 7.6 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDF35452.1 - 0.0031 16.7 0.0 0.46 9.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 CDF35452.1 - 0.0033 17.4 0.7 2.3 8.1 0.0 4.1 3 1 0 4 4 4 1 NTPase Zot PF05707.12 CDF35452.1 - 0.0045 16.7 0.0 0.43 10.2 0.0 2.8 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) UFD1 PF03152.14 CDF35452.1 - 0.0048 16.4 0.0 0.0089 15.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AAA_19 PF13245.6 CDF35452.1 - 0.0053 17.1 0.3 6.5 7.1 0.0 3.4 3 1 0 4 4 2 0 AAA domain Cytidylate_kin2 PF13189.6 CDF35452.1 - 0.0066 16.6 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_30 PF13604.6 CDF35452.1 - 0.0076 16.0 0.0 2.8 7.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 CDF35452.1 - 0.0094 15.7 0.0 4.4 7.0 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase AAA_11 PF13086.6 CDF35452.1 - 0.012 15.5 0.3 7.1 6.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 CDF35452.1 - 0.015 15.0 0.0 4.5 7.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain SKI PF01202.22 CDF35452.1 - 0.017 15.2 0.5 17 5.5 0.0 3.3 3 0 0 3 3 3 0 Shikimate kinase KAP_NTPase PF07693.14 CDF35452.1 - 0.02 14.2 0.2 0.74 9.0 0.0 2.8 2 2 2 4 4 4 0 KAP family P-loop domain T2SSE PF00437.20 CDF35452.1 - 0.033 13.3 0.0 2.4 7.2 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein KTI12 PF08433.10 CDF35452.1 - 0.077 12.4 0.1 6.3 6.1 0.0 2.5 2 1 0 2 2 2 0 Chromatin associated protein KTI12 DEAD PF00270.29 CDF35452.1 - 0.082 12.7 0.2 27 4.5 0.0 3.4 2 2 0 3 3 3 0 DEAD/DEAH box helicase AAA_23 PF13476.6 CDF35452.1 - 0.16 12.4 0.5 17 5.8 0.0 2.8 3 0 0 3 3 2 0 AAA domain Hydin_ADK PF17213.3 CDF35452.1 - 0.22 11.8 2.4 40 4.4 0.0 3.7 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain AFG1_ATPase PF03969.16 CDF35452.1 - 2.5 6.9 5.8 9 5.1 0.0 3.1 4 0 0 4 4 4 0 AFG1-like ATPase MID_MedPIWI PF18296.1 CDF35453.1 - 6e-07 29.5 0.0 6e-07 29.5 0.0 5.1 4 2 0 5 5 5 2 MID domain of medPIWI Med13_C PF06333.12 CDF35453.1 - 0.00014 21.2 2.0 0.00014 21.2 2.0 3.8 2 2 1 3 3 3 1 Mediator complex subunit 13 C-terminal domain FAA_hydrolase PF01557.18 CDF35454.1 - 6.6e-51 173.1 0.0 7.6e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Cytochrom_C PF00034.21 CDF35455.1 - 2.6e-12 47.7 0.0 3.6e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDF35455.1 - 1.1e-05 25.6 0.6 2.5e-05 24.5 0.6 1.6 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CDF35455.1 - 0.00067 19.4 0.1 0.0028 17.4 0.1 1.8 2 0 0 2 2 2 1 Cytochrome c-550 domain HAD_2 PF13419.6 CDF35457.1 - 1.7e-21 77.1 0.0 2.2e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF35457.1 - 1.1e-09 38.9 0.0 7.7e-09 36.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF35457.1 - 1.8e-05 25.2 0.0 2.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF35457.1 - 0.0028 17.7 0.1 0.0053 16.8 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDF35457.1 - 0.094 12.8 0.0 0.71 10.0 0.0 2.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase zf-RING_2 PF13639.6 CDF35458.1 - 3.5e-14 52.8 11.0 5.2e-14 52.3 11.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CDF35458.1 - 2.1e-09 37.2 9.1 3.5e-09 36.5 9.1 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDF35458.1 - 6.6e-09 35.5 10.3 1e-08 34.8 10.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF35458.1 - 1e-08 34.7 1.7 2.1e-08 33.8 1.7 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDF35458.1 - 2.4e-07 30.5 9.8 3.6e-07 29.9 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF35458.1 - 7.2e-07 29.4 11.5 1.9e-06 28.0 11.5 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CDF35458.1 - 2.7e-05 24.0 8.0 4.1e-05 23.5 8.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDF35458.1 - 0.0003 20.6 8.7 0.00073 19.3 8.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF35458.1 - 0.00064 19.5 12.7 0.0059 16.4 5.8 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CDF35458.1 - 0.0014 18.6 4.9 0.0049 16.9 4.9 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 CDF35458.1 - 0.022 14.5 7.0 0.04 13.7 7.0 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Tmpp129 PF10272.9 CDF35458.1 - 0.04 13.2 1.6 0.066 12.5 1.6 1.3 1 0 0 1 1 1 0 Putative transmembrane protein precursor zf-C3HC4_4 PF15227.6 CDF35458.1 - 0.13 12.5 10.1 0.23 11.7 10.1 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.14 CDF35458.1 - 0.23 11.3 3.1 0.52 10.2 0.4 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif FANCL_C PF11793.8 CDF35458.1 - 0.47 10.7 7.3 5.8 7.2 7.3 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 CDF35458.1 - 1.1 9.1 8.5 4.2 7.3 8.5 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zinc_ribbon_16 PF17034.5 CDF35458.1 - 1.4 9.1 6.1 1.2 9.3 4.8 1.5 1 1 0 1 1 1 0 Zinc-ribbon like family UPF0547 PF10571.9 CDF35458.1 - 3.7 7.7 8.4 1.9 8.6 0.2 2.9 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 LSM PF01423.22 CDF35461.1 - 1.7e-19 69.3 0.0 2.1e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain Fer4_16 PF13484.6 CDF35462.1 - 3.9e-19 69.4 3.0 7.4e-19 68.5 3.0 1.5 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain DUF1730 PF08331.10 CDF35462.1 - 2e-12 46.9 0.0 4.8e-12 45.6 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1730) Fer4_7 PF12838.7 CDF35462.1 - 8.8e-06 26.2 7.6 7.4e-05 23.3 7.9 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDF35462.1 - 0.0012 18.9 6.6 0.11 12.7 2.1 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain HEAT_2 PF13646.6 CDF35462.1 - 0.0043 17.4 1.5 0.012 16.0 1.0 1.8 1 1 1 2 2 2 1 HEAT repeats Fer4 PF00037.27 CDF35462.1 - 0.022 14.5 16.2 0.21 11.5 6.9 2.9 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_8 PF13183.6 CDF35462.1 - 0.023 15.1 2.9 0.67 10.4 0.7 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDF35462.1 - 0.029 14.5 9.2 0.59 10.3 9.8 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDF35462.1 - 0.2 11.8 16.3 2.9 8.2 0.5 3.2 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_21 PF14697.6 CDF35462.1 - 0.31 11.2 11.4 4.1 7.6 11.4 2.2 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDF35462.1 - 0.51 10.6 4.8 5.8 7.2 1.3 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDF35462.1 - 1.1 10.4 14.0 11 7.2 6.8 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 CDF35462.1 - 6.8 6.9 15.4 10 6.4 5.3 2.6 2 1 0 2 2 2 0 4Fe-4S binding domain PRONE PF03759.13 CDF35463.1 - 3.6e-50 170.8 0.2 1.6e-49 168.7 0.2 1.8 1 1 0 1 1 1 1 PRONE (Plant-specific Rop nucleotide exchanger) MIT PF04212.18 CDF35463.1 - 0.00075 19.5 0.2 0.0035 17.4 0.2 2.3 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF2388 PF09498.10 CDF35463.1 - 0.017 15.1 0.1 0.73 9.8 0.1 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2388) Agenet PF05641.12 CDF35464.1 - 1e-12 48.3 3.9 0.00015 22.2 0.1 3.6 3 0 0 3 3 3 3 Agenet domain MBD PF01429.19 CDF35464.1 - 2.5e-05 23.9 0.1 5.7e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain tRNA-synt_1e PF01406.19 CDF35465.1 - 1.9e-109 365.7 0.0 2.5e-109 365.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DALR_2 PF09190.11 CDF35465.1 - 1.6e-11 44.5 0.1 3.8e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 DALR domain tRNA-synt_1g PF09334.11 CDF35465.1 - 2.6e-09 36.4 0.1 0.00017 20.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 CDF35465.1 - 5e-05 22.4 0.0 0.013 14.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 CDF35465.1 - 0.00025 19.5 0.0 0.00041 18.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 CDF35465.1 - 0.081 11.8 0.1 0.23 10.3 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain SWIB PF02201.18 CDF35466.1 - 8.9e-40 134.4 0.3 5.5e-21 74.2 0.2 2.2 2 0 0 2 2 2 2 SWIB/MDM2 domain 2-Hacid_dh_C PF02826.19 CDF35467.1 - 7.8e-56 188.2 0.0 2.2e-55 186.8 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDF35467.1 - 2.1e-24 85.7 0.0 2.6e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDF35467.1 - 5.8e-06 26.6 0.1 2.3e-05 24.6 0.1 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CDF35467.1 - 0.015 15.4 0.3 0.026 14.6 0.3 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 CDF35467.1 - 0.05 13.5 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 CDF35467.1 - 0.084 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NGP1NT PF08153.12 CDF35468.1 - 1.1e-39 135.6 0.4 1.8e-39 134.9 0.4 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CDF35468.1 - 5.9e-16 58.6 0.2 1.9e-13 50.5 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF35468.1 - 7.5e-06 25.6 0.0 7.3e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDF35468.1 - 0.00024 21.0 0.0 0.00064 19.7 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 CDF35468.1 - 0.00066 19.2 0.0 0.19 11.1 0.0 2.7 2 1 1 3 3 3 2 ADP-ribosylation factor family Roc PF08477.13 CDF35468.1 - 0.15 12.3 0.0 17 5.6 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CDF35468.1 - 0.82 9.7 4.9 2.5 8.1 0.1 3.3 4 1 1 5 5 5 0 Dynamin family RRM_1 PF00076.22 CDF35469.1 - 1e-29 102.1 0.0 5.5e-16 58.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF35469.1 - 0.14 12.2 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif Mem_trans PF03547.18 CDF35470.1 - 0.074 11.4 3.0 0.086 11.2 3.0 1.1 1 0 0 1 1 1 0 Membrane transport protein SRP-alpha_N PF04086.13 CDF35470.1 - 0.16 11.8 44.2 0.23 11.4 44.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Macoilin PF09726.9 CDF35470.1 - 6.4 5.2 27.8 8.2 4.9 27.8 1.0 1 0 0 1 1 1 0 Macoilin family BSP_II PF05432.11 CDF35470.1 - 9.6 5.8 45.4 18 4.9 45.4 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) ArfGap PF01412.18 CDF35471.1 - 2e-19 69.8 0.0 2e-19 69.8 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PPTA PF01239.22 CDF35472.1 - 2.1e-06 27.3 3.9 0.004 16.8 0.2 3.5 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat Lycopene_cycl PF05834.12 CDF35473.1 - 7.7e-92 308.3 0.1 8.7e-92 308.1 0.1 1.0 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 CDF35473.1 - 0.23 10.5 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Kinesin PF00225.23 CDF35474.1 - 9.2e-106 353.5 0.0 2e-105 352.4 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDF35474.1 - 9.7e-46 155.4 0.0 2.1e-45 154.3 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Mucin15 PF15672.5 CDF35474.1 - 0.3 10.5 5.8 0.046 13.2 0.6 2.1 1 1 0 2 2 2 0 Cell-membrane associated Mucin15 SNF2_N PF00176.23 CDF35476.1 - 5.3e-68 229.3 0.0 8.7e-68 228.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 CDF35476.1 - 6.3e-25 88.1 13.5 6.3e-25 88.1 13.5 2.4 2 0 0 2 2 2 1 DNA-binding domain Helicase_C PF00271.31 CDF35476.1 - 1.9e-17 63.6 0.0 1e-16 61.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF35476.1 - 2.1e-07 31.1 0.1 2.9e-06 27.4 0.0 2.6 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF35476.1 - 0.00012 21.9 0.0 0.00046 20.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 CDF35476.1 - 0.0003 20.0 0.0 0.009 15.2 0.0 2.4 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 zf-WRNIP1_ubi PF18279.1 CDF35478.1 - 0.025 15.2 1.7 0.069 13.8 1.7 1.8 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain DDE_3 PF13358.6 CDF35484.1 - 1.4e-08 34.7 0.0 2.6e-08 33.8 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF35485.1 - 4.6e-11 42.4 0.0 7.2e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF35485.1 - 2.3e-06 27.3 0.1 5.8e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF35485.1 - 6.2e-06 25.8 0.1 1.7e-05 24.5 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain GAIN_A PF18619.1 CDF35485.1 - 0.038 14.2 0.1 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A HTH_29 PF13551.6 CDF35485.1 - 0.071 13.1 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_24 PF13412.6 CDF35485.1 - 0.087 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Oxygenase-NA PF09859.9 CDF35487.1 - 0.067 12.7 0.0 0.081 12.5 0.0 1.1 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA AMP-binding PF00501.28 CDF35489.1 - 5.1e-71 239.5 0.3 7.1e-71 239.0 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDF35489.1 - 9.5e-12 45.7 7.6 3e-11 44.1 7.6 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CoA_binding PF02629.19 CDF35489.1 - 0.19 12.4 1.4 0.48 11.1 1.4 1.6 1 0 0 1 1 1 0 CoA binding domain Cpn60_TCP1 PF00118.24 CDF35491.1 - 1.1e-152 509.2 2.2 1.2e-152 509.0 2.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Methyltransf_3 PF01596.17 CDF35492.1 - 8e-50 169.0 0.8 1.1e-49 168.6 0.8 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CDF35492.1 - 9.5e-12 45.9 0.2 1.7e-11 45.1 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF35492.1 - 1.1e-07 31.8 0.3 1.6e-07 31.3 0.3 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDF35492.1 - 1.9e-07 31.1 0.1 2.7e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 CDF35492.1 - 2.3e-06 27.4 0.0 3.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDF35492.1 - 1e-05 26.2 0.1 2.1e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 CDF35492.1 - 0.0034 16.8 0.6 0.0049 16.3 0.6 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain MTS PF05175.14 CDF35492.1 - 0.0054 16.3 0.1 0.0087 15.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain GCD14 PF08704.10 CDF35492.1 - 0.0068 16.1 0.1 0.01 15.5 0.1 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_23 PF13489.6 CDF35492.1 - 0.0071 16.2 0.0 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDF35492.1 - 0.0082 15.5 0.1 0.012 15.0 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CDF35492.1 - 0.057 12.8 0.1 0.075 12.4 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Glycolytic PF00274.19 CDF35493.1 - 2.7e-129 430.9 0.0 3.4e-129 430.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Abhydrolase_1 PF00561.20 CDF35496.1 - 1.9e-14 54.0 0.0 8.6e-14 51.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF35496.1 - 9.3e-13 49.3 5.6 1.1e-12 49.0 5.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF35496.1 - 3.3e-12 46.2 0.2 9e-12 44.8 0.2 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 CDF35496.1 - 0.00018 21.2 0.0 0.00067 19.3 0.0 1.8 2 0 0 2 2 2 1 Dienelactone hydrolase family Ser_hydrolase PF06821.13 CDF35496.1 - 0.00029 20.7 0.1 0.01 15.7 0.0 2.2 2 0 0 2 2 2 1 Serine hydrolase LIDHydrolase PF10230.9 CDF35496.1 - 0.0003 20.5 0.0 0.00049 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ndr PF03096.14 CDF35496.1 - 0.00035 19.4 0.0 0.0077 15.0 0.0 2.0 2 0 0 2 2 2 1 Ndr family Peptidase_S9 PF00326.21 CDF35496.1 - 0.0046 16.4 0.0 0.022 14.2 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 CDF35496.1 - 0.014 15.1 0.0 3.9 7.2 0.0 2.4 3 0 0 3 3 3 0 Alpha/beta hydrolase family DUF3530 PF12048.8 CDF35496.1 - 0.07 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Thioesterase PF00975.20 CDF35496.1 - 0.088 12.9 0.0 0.2 11.7 0.0 1.5 2 0 0 2 2 2 0 Thioesterase domain GHMP_kinases_N PF00288.26 CDF35497.1 - 5.7e-11 42.5 0.4 1.4e-10 41.3 0.4 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.9 CDF35497.1 - 0.023 14.2 0.0 0.1 12.2 0.0 2.0 2 0 0 2 2 2 0 Galactokinase galactose-binding signature NUDIX PF00293.28 CDF35498.1 - 1.9e-06 27.9 0.0 3.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain zf-LYAR PF08790.11 CDF35499.1 - 2e-14 53.2 6.7 2.5e-13 49.6 0.6 2.4 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger DUF3375 PF11855.8 CDF35499.1 - 0.0032 16.5 2.2 0.0042 16.1 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3375) DM PF00751.18 CDF35499.1 - 0.0061 16.4 2.1 0.021 14.7 2.1 1.9 1 0 0 1 1 1 1 DM DNA binding domain zf-met PF12874.7 CDF35499.1 - 0.0087 16.4 2.0 0.0087 16.4 2.0 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Cas_CXXC_CXXC PF09706.10 CDF35499.1 - 0.08 13.2 0.3 0.25 11.6 0.3 1.8 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) zf-C2H2_2 PF12756.7 CDF35499.1 - 0.3 11.5 8.9 1 9.7 1.3 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CDF35499.1 - 0.75 10.8 10.6 2.3 9.3 1.8 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 CDF35499.1 - 1.2 9.3 6.0 0.17 12.0 1.5 2.0 2 0 0 2 2 2 0 Zinc ribbon domain zf-UBP PF02148.19 CDF35499.1 - 6.4 7.2 9.7 5.7e+02 0.9 9.7 2.4 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein hNIFK_binding PF12196.8 CDF35501.1 - 1.6 8.2 5.4 5.6 6.5 5.4 1.9 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK HD_4 PF13328.6 CDF35502.1 - 2.6e-33 115.0 8.8 1.1e-24 87.0 2.9 3.3 4 0 0 4 4 4 2 HD domain RelA_SpoT PF04607.17 CDF35502.1 - 3.8e-24 85.2 0.0 1.8e-23 83.0 0.0 2.2 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins TGS PF02824.21 CDF35502.1 - 2.5e-23 81.9 0.2 3.5e-22 78.2 0.1 2.8 2 0 0 2 2 2 1 TGS domain ACT_4 PF13291.6 CDF35502.1 - 8.1e-08 32.8 0.0 2e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 ACT domain HD PF01966.22 CDF35502.1 - 8.5e-05 22.8 0.4 0.0017 18.5 0.2 2.9 2 1 0 2 2 2 1 HD domain ACT PF01842.25 CDF35502.1 - 0.051 13.4 0.1 0.19 11.6 0.1 2.0 1 0 0 1 1 1 0 ACT domain NUDIX_2 PF13869.6 CDF35503.1 - 6.3e-63 211.8 0.0 8.8e-63 211.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 CDF35503.1 - 2.2e-06 27.7 0.0 3.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Sa_NUDIX PF18167.1 CDF35503.1 - 0.064 13.1 0.0 0.32 10.8 0.0 2.0 1 1 1 2 2 2 0 SMODS-associated NUDIX domain DUF2733 PF10813.8 CDF35504.1 - 0.11 12.3 0.2 0.21 11.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2733) Tim17 PF02466.19 CDF35505.1 - 1.2e-09 38.5 5.2 2.7e-09 37.4 5.2 1.7 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family 3HCDH_N PF02737.18 CDF35505.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cpn60_TCP1 PF00118.24 CDF35506.1 - 1.3e-95 320.9 11.6 1.9e-95 320.4 11.6 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rav1p_C PF12234.8 CDF35507.1 - 1.2e-46 159.4 0.4 2e-46 158.7 0.4 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal WD40 PF00400.32 CDF35507.1 - 2.4e-12 47.1 22.1 0.0022 18.8 0.0 9.2 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35507.1 - 3.6e-09 36.8 0.3 0.55 10.6 0.0 5.9 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Acetyltransf_1 PF00583.25 CDF35510.1 - 1.1e-14 54.7 0.0 1.3e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF35510.1 - 5.7e-09 36.3 0.0 8.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDF35510.1 - 2.4e-08 34.0 0.0 3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDF35510.1 - 0.0058 16.7 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF35510.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Spc7 PF08317.11 CDF35514.1 - 5.7e-05 22.1 259.7 6.2e-05 22.0 9.5 13.5 1 1 15 16 16 16 12 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 CDF35514.1 - 0.0047 16.9 4.4 0.0047 16.9 4.4 23.4 7 5 14 25 25 25 5 TATA element modulatory factor 1 DNA binding Tropomyosin PF00261.20 CDF35514.1 - 0.076 12.4 293.9 0.033 13.6 24.2 13.1 2 2 9 11 11 11 0 Tropomyosin Det1 PF09737.9 CDF35517.1 - 2.9e-64 217.7 0.0 2.3e-38 132.3 0.0 3.1 2 1 0 2 2 2 2 De-etiolated protein 1 Det1 Sacchrp_dh_NADP PF03435.18 CDF35518.1 - 6.7e-14 52.3 0.0 1.2e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CDF35518.1 - 9.6e-07 28.5 0.0 1.6e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CDF35518.1 - 0.0013 19.1 0.0 0.0026 18.2 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CDF35518.1 - 0.0021 17.1 0.0 0.0035 16.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDF35518.1 - 0.005 16.0 0.0 0.011 14.8 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CDF35518.1 - 0.0073 16.2 0.6 0.085 12.7 0.6 2.2 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CDF35518.1 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase KR PF08659.10 CDF35518.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 KR domain DapB_N PF01113.20 CDF35518.1 - 0.15 12.1 0.1 0.72 10.0 0.1 2.1 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 CDF35518.1 - 0.16 11.0 0.0 0.38 9.8 0.0 1.6 1 1 0 1 1 1 0 RmlD substrate binding domain TPT PF03151.16 CDF35519.1 - 1.1e-17 64.4 20.1 1.3e-17 64.1 20.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CDF35519.1 - 1.1e-10 41.2 20.5 1.4e-10 40.8 20.5 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDF35519.1 - 5.7e-05 23.3 33.3 0.00065 19.9 15.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family ATP-synt_I PF03899.15 CDF35519.1 - 7.5 7.0 21.1 7.7 7.0 1.3 3.4 2 2 1 3 3 3 0 ATP synthase I chain Rad1 PF02144.16 CDF35520.1 - 5.7e-36 124.0 0.0 7.5e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Cullin_binding PF03556.15 CDF35522.1 - 6.7e-28 97.6 0.0 1.1e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Cullin binding ARL2_Bind_BART PF11527.8 CDF35522.1 - 0.097 12.8 0.1 0.97 9.6 0.1 2.2 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART WD40 PF00400.32 CDF35523.1 - 2.4e-65 214.9 8.9 1.9e-11 44.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35523.1 - 2.5e-28 98.2 0.0 1.2e-05 25.5 0.0 5.7 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF35523.1 - 9.3e-12 45.2 0.0 7.3e-07 29.3 0.0 3.6 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CDF35523.1 - 9.4e-11 41.0 0.3 0.077 11.6 0.0 5.6 2 2 4 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 CDF35523.1 - 1.7e-08 34.1 0.0 0.01 15.2 0.0 3.5 2 1 1 3 3 3 3 WD40-like domain VID27 PF08553.10 CDF35523.1 - 4.1e-06 26.1 0.0 0.23 10.5 0.0 3.5 2 1 2 4 4 4 3 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 CDF35523.1 - 1.1e-05 24.5 0.0 0.23 10.4 0.0 3.5 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CDF35523.1 - 4.1e-05 22.3 0.2 0.21 10.0 0.0 3.2 1 1 3 4 4 4 3 Cytochrome D1 heme domain Frtz PF11768.8 CDF35523.1 - 0.00035 19.0 0.0 0.04 12.2 0.0 2.4 1 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF5046 PF16465.5 CDF35523.1 - 0.00035 20.1 0.0 2.5 7.5 0.0 3.4 2 1 2 4 4 4 1 Domain of unknown function (DUF5046) Coatomer_WDAD PF04053.14 CDF35523.1 - 0.00072 18.7 0.2 0.019 14.0 0.1 2.6 2 1 0 3 3 3 1 Coatomer WD associated region PALB2_WD40 PF16756.5 CDF35523.1 - 0.0069 15.3 0.3 1.5 7.7 0.0 3.5 1 1 3 4 4 4 1 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 CDF35523.1 - 0.025 14.2 0.1 0.18 11.4 0.0 2.4 2 1 0 2 2 2 0 PQQ-like domain PD40 PF07676.12 CDF35523.1 - 0.042 13.8 2.0 22 5.1 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Serglycin PF04360.12 CDF35523.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Serglycin PQQ PF01011.21 CDF35523.1 - 0.16 11.9 1.5 34 4.6 0.4 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat Smr PF01713.21 CDF35524.1 - 5e-10 39.6 0.1 1.3e-09 38.3 0.1 1.7 1 0 0 1 1 1 1 Smr domain TPT PF03151.16 CDF35525.1 - 2.2e-26 92.9 16.5 2.6e-26 92.7 16.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CDF35525.1 - 7.1e-06 25.4 20.2 6.9e-05 22.2 20.2 1.9 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDF35525.1 - 9.2e-05 22.6 25.1 0.00044 20.4 10.6 2.2 2 0 0 2 2 2 2 EamA-like transporter family CSN8_PSD8_EIF3K PF10075.9 CDF35530.1 - 2.5e-22 79.4 0.0 3.4e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family MINDY_DUB PF04424.13 CDF35531.1 - 5e-25 87.8 0.0 8.4e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase Pkinase PF00069.25 CDF35532.1 - 8.2e-61 205.7 0.0 1.8e-60 204.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35532.1 - 8.3e-41 140.0 0.0 1.1e-40 139.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CDF35532.1 - 2.9e-07 30.7 0.0 5.5e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 CDF35532.1 - 2.8e-06 26.4 0.0 4.1e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 CDF35532.1 - 0.00073 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CDF35532.1 - 0.0033 17.4 0.2 0.43 10.5 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF35532.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 CDF35532.1 - 0.078 11.9 0.0 0.43 9.5 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Ribosomal_L30_N PF08079.12 CDF35533.1 - 1.6e-21 76.4 14.1 3.3e-21 75.3 14.1 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 CDF35533.1 - 1.4e-19 69.7 0.8 1.4e-19 69.7 0.8 1.8 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Kelch_1 PF01344.25 CDF35535.1 - 2.1e-31 107.3 7.4 4.3e-11 42.2 0.1 7.2 7 0 0 7 7 7 4 Kelch motif Kelch_5 PF13854.6 CDF35535.1 - 8.1e-31 105.5 1.0 4.4e-06 26.6 0.1 5.8 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 CDF35535.1 - 4.7e-30 103.3 4.4 1.4e-06 28.5 0.0 7.3 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.6 CDF35535.1 - 1.8e-29 101.5 2.4 1.6e-08 34.4 0.0 6.4 7 0 0 7 7 7 4 Galactose oxidase, central domain BTB PF00651.31 CDF35535.1 - 6.5e-28 97.2 0.5 1.4e-27 96.1 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.6 CDF35535.1 - 2.2e-24 84.9 6.1 4.3e-07 30.0 0.0 6.6 6 1 1 7 7 7 4 Kelch motif Kelch_2 PF07646.15 CDF35535.1 - 4.6e-23 80.3 7.9 1.5e-08 34.2 0.0 6.2 7 0 0 7 7 7 4 Kelch motif BACK PF07707.15 CDF35535.1 - 3.5e-05 23.8 0.9 7.8e-05 22.7 0.3 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB_3 PF16017.5 CDF35535.1 - 0.0052 16.9 0.1 0.016 15.3 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain DUF1247 PF06851.11 CDF35535.1 - 0.12 12.3 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) Pkinase PF00069.25 CDF35536.1 - 4.1e-47 160.8 0.0 4.8e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35536.1 - 1.4e-21 76.9 0.0 1.7e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF35536.1 - 2.5e-06 26.6 0.0 3.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF35536.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PAP_central PF04928.17 CDF35537.1 - 7.4e-95 316.6 0.0 1.1e-94 316.1 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 CDF35537.1 - 7.8e-20 71.2 0.0 4.4e-14 52.5 0.0 2.6 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 CDF35537.1 - 6.4e-08 32.8 0.0 1.4e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 CDF35537.1 - 0.003 17.4 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain Totivirus_coat PF05518.11 CDF35538.1 - 8e-30 103.6 0.0 1.3e-28 99.6 0.0 2.2 1 1 0 1 1 1 1 Totivirus coat protein UAA PF08449.11 CDF35539.1 - 8.7e-64 215.6 15.0 9.9e-64 215.4 15.0 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDF35539.1 - 9.8e-05 22.5 26.4 0.0047 17.1 3.2 2.7 3 0 0 3 3 3 2 EamA-like transporter family adh_short PF00106.25 CDF35541.1 - 2.4e-36 125.0 0.2 3.1e-36 124.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF35541.1 - 1.1e-29 103.7 0.1 1.4e-29 103.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF35541.1 - 0.00025 21.0 0.1 0.00049 20.0 0.1 1.4 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CDF35541.1 - 0.022 14.1 0.0 0.055 12.8 0.0 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Uma2 PF05685.12 CDF35543.1 - 3.3e-20 72.3 0.0 4.6e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease DUF2514 PF10721.9 CDF35543.1 - 1.2 9.1 14.0 1.9 8.5 14.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) FoP_duplication PF13865.6 CDF35543.1 - 1.4 9.5 7.2 2.8 8.6 7.2 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 XRN_M PF17846.1 CDF35543.1 - 4.2 6.2 5.2 7.2 5.5 5.2 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Zip PF02535.22 CDF35546.1 - 3.7e-35 121.7 17.6 4.7e-34 118.1 17.6 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter CENP-B_dimeris PF09026.10 CDF35546.1 - 0.04 14.3 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pkinase PF00069.25 CDF35547.1 - 7.7e-63 212.3 0.0 1e-62 211.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35547.1 - 3.9e-27 95.2 0.0 5.7e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF35547.1 - 7.6e-09 35.3 0.0 6.2e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PH PF00169.29 CDF35547.1 - 3.9e-05 24.1 0.0 8.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_17 PF18012.1 CDF35547.1 - 0.0044 16.7 0.0 0.076 12.8 0.0 2.4 2 0 0 2 2 2 1 PH domain APH PF01636.23 CDF35547.1 - 0.022 14.7 0.1 1.7 8.5 0.1 2.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDF35547.1 - 0.045 12.7 0.0 0.068 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain ABM PF03992.16 CDF35549.1 - 2.7e-22 78.7 0.1 3.1e-22 78.5 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Macro PF01661.21 CDF35550.1 - 9.7e-67 222.4 0.0 6.7e-39 132.6 0.0 2.2 2 0 0 2 2 2 2 Macro domain Yippee-Mis18 PF03226.14 CDF35551.1 - 3.1e-18 65.9 3.0 5.5e-18 65.1 3.0 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF4164 PF13747.6 CDF35551.1 - 0.05 13.9 0.2 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) SelR PF01641.18 CDF35551.1 - 0.084 13.0 0.8 0.33 11.0 0.7 1.9 1 1 1 2 2 2 0 SelR domain Peptidase_M24 PF00557.24 CDF35552.1 - 1.3e-40 139.3 0.1 1.9e-40 138.8 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AP3D1 PF06375.11 CDF35552.1 - 0.0094 16.2 4.6 0.017 15.3 4.6 1.3 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 NST1 PF13945.6 CDF35552.1 - 0.022 14.9 2.6 0.035 14.2 2.6 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Herpes_TAF50 PF03326.13 CDF35552.1 - 0.035 12.8 1.6 0.24 10.0 2.1 1.8 2 0 0 2 2 2 0 Herpesvirus transcription activation factor (transactivator) S4 PF01479.25 CDF35553.1 - 8.1e-11 41.5 1.0 8.1e-11 41.5 1.0 1.9 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 CDF35553.1 - 8.3e-06 26.6 0.3 1.9e-05 25.5 0.3 1.7 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain FAD_binding_3 PF01494.19 CDF35554.1 - 3.6e-11 42.9 0.3 1.2e-05 24.8 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CDF35554.1 - 9.3e-06 25.1 0.1 1.7e-05 24.2 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF35554.1 - 4e-05 22.9 0.1 6.5e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 CDF35554.1 - 0.00023 20.9 0.2 0.044 13.4 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDF35554.1 - 0.00031 20.8 0.1 1.5 8.8 0.0 3.4 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CDF35554.1 - 0.00041 20.5 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CDF35554.1 - 0.0014 18.1 0.2 0.0028 17.1 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDF35554.1 - 0.0016 17.2 0.1 0.0024 16.6 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 CDF35554.1 - 0.0041 16.2 1.4 1.9 7.5 0.1 2.5 3 1 0 3 3 3 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 CDF35554.1 - 0.0045 16.1 0.3 0.011 14.9 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 CDF35554.1 - 0.013 15.4 0.1 0.18 11.7 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 CDF35554.1 - 0.02 14.2 0.1 0.036 13.3 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CDF35554.1 - 0.026 15.1 0.0 0.077 13.6 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CDF35554.1 - 0.1 11.4 0.5 1.7 7.4 0.1 2.5 2 1 0 2 2 2 0 Tryptophan halogenase Hemerythrin PF01814.23 CDF35556.1 - 9.9e-06 26.2 1.7 2.2e-05 25.1 1.7 1.6 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Soyouz_module PF14313.6 CDF35556.1 - 0.013 15.3 0.2 0.037 13.8 0.2 1.8 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) Imm68 PF15583.6 CDF35556.1 - 0.22 11.7 2.0 0.49 10.6 0.5 2.1 2 0 0 2 2 2 0 Immunity protein 68 Methyltransf_11 PF08241.12 CDF35557.1 - 2.3e-10 41.0 0.0 3.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF35557.1 - 2e-06 28.4 0.0 8.9e-06 26.3 0.0 2.0 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF35557.1 - 9.8e-06 25.5 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF35557.1 - 1.7e-05 24.2 0.0 3.8e-05 23.1 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDF35557.1 - 4.8e-05 23.2 0.0 6.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF35557.1 - 0.0025 18.5 0.0 0.004 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CDF35557.1 - 0.045 13.3 0.0 0.057 13.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW N6_N4_Mtase PF01555.18 CDF35557.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 DNA methylase Methyltransf_29 PF03141.16 CDF35557.1 - 0.12 10.9 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 CDF35557.1 - 0.16 11.8 0.0 0.22 11.4 0.0 1.1 1 0 0 1 1 1 0 Hypothetical methyltransferase Cation_efflux PF01545.21 CDF35558.1 - 5.7e-24 84.9 11.2 5.7e-24 84.9 11.2 3.2 3 1 0 3 3 3 2 Cation efflux family UCH PF00443.29 CDF35560.1 - 1.7e-30 106.4 0.0 2.2e-30 106.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CDF35560.1 - 1.8e-13 50.6 0.4 3.5e-13 49.7 0.4 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CDF35560.1 - 0.024 14.2 0.4 0.22 11.1 0.1 2.5 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase PAXNEB PF05625.11 CDF35561.1 - 1.1e-43 149.8 0.0 1.7e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 PAXNEB protein Abhydrolase_6 PF12697.7 CDF35562.1 - 1.4e-18 68.3 0.2 2.7e-18 67.4 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF35562.1 - 3e-18 66.0 0.0 4.9e-18 65.3 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF35562.1 - 6.9e-18 65.2 0.1 6.3e-14 52.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDF35562.1 - 0.038 13.8 0.0 2.9 7.6 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydro_lipase PF04083.16 CDF35562.1 - 0.057 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region LIDHydrolase PF10230.9 CDF35562.1 - 0.12 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase SRP9-21 PF05486.12 CDF35563.1 - 5e-09 36.4 1.0 2.5e-07 31.0 1.0 2.1 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) LYTB PF02401.18 CDF35564.1 - 1.8e-77 260.1 0.0 2.2e-77 259.9 0.0 1.1 1 0 0 1 1 1 1 LytB protein LMWPc PF01451.21 CDF35566.1 - 0.0026 18.1 0.0 0.0037 17.7 0.0 1.2 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Sds3 PF08598.11 CDF35568.1 - 0.00058 19.9 0.1 0.0039 17.2 0.1 2.0 2 0 0 2 2 2 1 Sds3-like Aminotran_1_2 PF00155.21 CDF35569.1 - 2.6e-33 115.7 0.0 3.6e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DTW PF03942.15 CDF35569.1 - 2e-28 99.5 0.1 4.4e-28 98.4 0.1 1.5 1 0 0 1 1 1 1 DTW domain Cys_Met_Meta_PP PF01053.20 CDF35569.1 - 0.1 11.1 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme TatD_DNase PF01026.21 CDF35570.1 - 3.7e-51 174.0 0.0 4.7e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Aminotran_1_2 PF00155.21 CDF35571.1 - 6.1e-38 130.9 0.0 7.1e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDF35571.1 - 5.5e-05 22.6 0.0 0.00012 21.5 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CDF35571.1 - 0.094 11.2 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme SPOR PF05036.13 CDF35571.1 - 0.12 12.8 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 Sporulation related domain AAA PF00004.29 CDF35573.1 - 9.4e-61 204.0 0.0 4.1e-37 127.6 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF35573.1 - 7.8e-17 60.8 0.1 6.6e-09 35.4 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CDF35573.1 - 5.1e-12 46.5 0.2 0.00065 20.1 0.0 3.6 2 1 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CDF35573.1 - 2.1e-11 44.0 0.0 3.7e-06 27.0 0.0 3.5 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDF35573.1 - 2e-07 31.3 0.0 0.027 14.6 0.0 2.6 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 CDF35573.1 - 1.2e-06 28.6 0.0 0.059 13.3 0.0 2.8 2 1 1 3 3 3 2 Rad17 P-loop domain RuvB_N PF05496.12 CDF35573.1 - 4e-06 26.7 0.0 0.065 13.0 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF35573.1 - 2.4e-05 24.6 0.3 0.97 9.7 0.1 3.9 2 2 1 3 3 3 2 AAA domain AAA_14 PF13173.6 CDF35573.1 - 2.7e-05 24.2 0.0 0.35 10.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CDF35573.1 - 5.2e-05 23.4 0.0 0.37 11.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 CDF35573.1 - 9.3e-05 21.8 0.0 0.0067 15.7 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_3 PF07726.11 CDF35573.1 - 0.00011 22.1 0.0 3.7 7.4 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDF35573.1 - 0.00014 22.2 0.0 0.18 12.2 0.0 2.4 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 CDF35573.1 - 0.00018 22.1 0.0 0.18 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 CDF35573.1 - 0.00023 21.1 0.0 0.18 11.7 0.0 2.6 2 1 0 2 2 2 1 NTPase Zeta_toxin PF06414.12 CDF35573.1 - 0.00044 19.6 0.0 0.1 11.8 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_11 PF13086.6 CDF35573.1 - 0.0012 18.7 0.0 1.9 8.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CDF35573.1 - 0.0047 17.3 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CDF35573.1 - 0.0066 16.5 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDF35573.1 - 0.0081 15.9 0.0 0.84 9.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.16 CDF35573.1 - 0.0097 14.8 0.0 0.084 11.7 0.0 2.0 2 0 0 2 2 2 1 AFG1-like ATPase TsaE PF02367.17 CDF35573.1 - 0.012 15.7 0.0 7.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 CDF35573.1 - 0.013 14.9 0.1 7.4 5.9 0.0 2.8 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDF35573.1 - 0.018 15.3 0.0 4.7 7.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDF35573.1 - 0.022 14.5 0.0 4.7 6.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDF35573.1 - 0.026 14.1 0.0 3.8 7.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 CDF35573.1 - 0.037 13.2 0.0 0.43 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_17 PF13207.6 CDF35573.1 - 0.042 14.3 0.1 2.5 8.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CDF35573.1 - 0.07 12.7 0.0 7 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDF35573.1 - 0.073 12.8 0.0 10 5.7 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TPP_enzyme_M PF00205.22 CDF35573.1 - 0.084 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain ATPase_2 PF01637.18 CDF35573.1 - 0.092 12.6 0.0 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDF35573.1 - 0.12 12.1 0.0 13 5.5 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 CDF35573.1 - 0.15 11.9 0.0 28 4.6 0.0 2.6 3 0 0 3 3 2 0 NACHT domain GREB1 PF15782.5 CDF35573.1 - 0.18 8.9 0.0 0.3 8.2 0.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer zf-C2H2 PF00096.26 CDF35574.1 - 2.7e-05 24.4 0.3 2.7e-05 24.4 0.3 3.7 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF35574.1 - 7.4e-05 23.3 0.3 7.4e-05 23.3 0.3 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CDF35574.1 - 0.00019 21.1 0.6 0.00019 21.1 0.6 2.6 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 CDF35574.1 - 0.0042 17.5 0.2 0.0042 17.5 0.2 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDF35574.1 - 0.0071 16.3 1.3 0.0071 16.3 1.3 2.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 CDF35574.1 - 0.021 15.2 0.0 0.098 13.1 0.0 2.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 CDF35574.1 - 0.037 14.3 0.2 0.037 14.3 0.2 3.1 4 0 0 4 4 3 0 Drought induced 19 protein (Di19), zinc-binding Endonuclease_7 PF02945.15 CDF35574.1 - 0.054 13.4 0.2 0.15 12.0 0.2 1.7 1 0 0 1 1 1 0 Recombination endonuclease VII zf-H2C2_5 PF13909.6 CDF35574.1 - 0.067 13.0 3.5 5 7.0 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Zn-C2H2_12 PF18112.1 CDF35574.1 - 0.18 12.3 3.0 0.38 11.3 0.1 2.9 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Rad50_zn_hook PF04423.14 CDF35574.1 - 1.4 8.8 3.9 0.88 9.5 0.1 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif AAA PF00004.29 CDF35575.1 - 1e-41 142.5 0.0 1.8e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF35575.1 - 2.3e-11 43.3 0.8 4e-11 42.5 0.1 1.8 2 0 0 2 2 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDF35575.1 - 2.2e-08 33.9 0.0 6e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 CDF35575.1 - 7e-08 33.0 0.4 4.4e-05 23.9 0.1 2.8 2 1 0 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 CDF35575.1 - 2.3e-06 27.6 0.1 2.2e-05 24.5 0.1 2.5 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDF35575.1 - 1.4e-05 25.2 0.0 0.00018 21.7 0.0 2.4 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDF35575.1 - 2.3e-05 24.2 0.0 5.9e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF35575.1 - 3.2e-05 24.2 0.3 0.018 15.3 0.0 2.8 2 1 1 3 3 2 1 AAA domain AAA_18 PF13238.6 CDF35575.1 - 0.00028 21.4 0.0 0.0011 19.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 CDF35575.1 - 0.00053 19.3 0.0 0.0009 18.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 CDF35575.1 - 0.002 17.3 0.0 0.0042 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CDF35575.1 - 0.0032 17.2 0.0 0.0068 16.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDF35575.1 - 0.0044 16.4 0.0 0.0078 15.6 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDF35575.1 - 0.0046 16.5 0.0 0.011 15.2 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 CDF35575.1 - 0.0066 16.8 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Sigma54_activat PF00158.26 CDF35575.1 - 0.013 15.2 0.0 0.041 13.6 0.0 1.8 2 1 1 3 3 2 0 Sigma-54 interaction domain AAA_33 PF13671.6 CDF35575.1 - 0.018 15.2 0.0 0.041 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDF35575.1 - 0.022 14.8 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDF35575.1 - 0.022 14.5 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDF35575.1 - 0.024 14.6 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CDF35575.1 - 0.03 14.0 0.2 0.099 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CDF35575.1 - 0.043 13.2 0.0 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.6 CDF35575.1 - 0.044 14.0 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF4200 PF13863.6 CDF35575.1 - 0.046 14.1 0.7 0.11 12.9 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_3 PF07726.11 CDF35575.1 - 0.057 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TPR_MLP1_2 PF07926.12 CDF35575.1 - 0.059 13.4 0.5 0.12 12.5 0.5 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Parvo_NS1 PF01057.17 CDF35575.1 - 0.07 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 CDF35575.1 - 0.083 12.8 0.1 0.44 10.4 0.0 2.2 1 1 0 2 2 2 0 NACHT domain CPT PF07931.12 CDF35575.1 - 0.096 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PhoH PF02562.16 CDF35575.1 - 0.11 11.9 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein Arf PF00025.21 CDF35576.1 - 4.3e-77 257.5 0.1 5.1e-77 257.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDF35576.1 - 1.8e-14 53.9 0.1 2.5e-14 53.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDF35576.1 - 1.2e-13 51.0 1.2 1.7e-09 37.4 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CDF35576.1 - 1.9e-13 50.3 0.0 2.1e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDF35576.1 - 1.1e-12 47.7 0.0 1.4e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDF35576.1 - 3.9e-12 46.0 0.0 5.1e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDF35576.1 - 2.5e-06 27.5 0.1 3.6e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CDF35576.1 - 0.0042 16.4 0.3 0.021 14.2 0.1 1.9 2 0 0 2 2 2 1 6-phosphofructo-2-kinase cobW PF02492.19 CDF35576.1 - 0.088 12.4 0.2 0.64 9.6 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CTP_transf_like PF01467.26 CDF35577.1 - 1.8e-05 25.0 0.0 0.00026 21.2 0.0 2.3 1 1 0 1 1 1 1 Cytidylyltransferase-like CinA PF02464.17 CDF35577.1 - 0.09 12.3 0.1 0.94 9.0 0.0 2.4 1 1 2 3 3 3 0 Competence-damaged protein zf-RING_2 PF13639.6 CDF35579.1 - 3.5e-14 52.8 4.6 5.6e-14 52.2 4.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDF35579.1 - 9e-11 41.3 2.0 9e-11 41.3 2.0 1.8 1 1 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF35579.1 - 1.1e-07 31.5 3.7 1.7e-07 31.0 3.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF35579.1 - 1.5e-07 31.1 2.1 2.4e-07 30.5 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF35579.1 - 2.9e-07 30.2 3.8 4.4e-07 29.6 3.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF35579.1 - 7.2e-06 25.9 2.3 1.2e-05 25.1 2.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CDF35579.1 - 2.7e-05 24.4 7.8 0.00022 21.5 7.8 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDF35579.1 - 0.00016 21.6 4.5 0.00027 20.9 4.5 1.4 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDF35579.1 - 0.00053 19.8 5.3 0.00088 19.1 5.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CDF35579.1 - 0.058 13.2 2.4 0.098 12.5 2.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Baculo_RING PF05883.11 CDF35579.1 - 0.17 11.9 0.4 0.29 11.1 0.4 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.8 CDF35579.1 - 0.2 11.8 6.2 1.4 9.1 6.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CDF35579.1 - 0.22 11.2 3.9 0.39 10.4 3.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Tmpp129 PF10272.9 CDF35579.1 - 0.75 9.0 2.6 1.1 8.6 2.6 1.1 1 0 0 1 1 1 0 Putative transmembrane protein precursor VCX_VCY PF15231.6 CDF35581.1 - 0.13 13.0 0.4 0.14 12.8 0.4 1.1 1 0 0 1 1 1 0 Variable charge X/Y family PGK PF00162.19 CDF35582.1 - 2e-162 540.4 0.3 2.3e-162 540.2 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PrpR_N PF06506.11 CDF35582.1 - 0.088 12.4 0.8 6.1 6.4 0.0 3.1 2 1 1 3 3 3 0 Propionate catabolism activator Myticin-prepro PF10690.9 CDF35583.1 - 0.093 13.0 1.5 0.13 12.5 1.5 1.3 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel AAA_25 PF13481.6 CDF35584.1 - 8.7e-24 84.2 0.0 1.5e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CDF35584.1 - 1.8e-11 43.9 0.0 2.8e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Toprim_2 PF13155.6 CDF35584.1 - 8.9e-09 35.7 0.0 1.9e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Toprim-like AAA_16 PF13191.6 CDF35584.1 - 0.00011 22.6 0.0 0.00025 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Toprim_3 PF13362.6 CDF35584.1 - 0.0013 19.1 0.0 0.0047 17.3 0.0 1.9 2 0 0 2 2 2 1 Toprim domain Toprim_4 PF13662.6 CDF35584.1 - 0.0072 16.8 0.0 0.024 15.1 0.0 1.9 1 1 0 1 1 1 1 Toprim domain RsgA_GTPase PF03193.16 CDF35584.1 - 0.011 15.7 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 CDF35584.1 - 0.011 16.2 0.0 0.023 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3991 PF13154.6 CDF35584.1 - 0.012 16.0 0.0 0.033 14.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3991) ATPase PF06745.13 CDF35584.1 - 0.02 14.3 0.0 0.046 13.1 0.0 1.5 1 1 0 1 1 1 0 KaiC AAA_22 PF13401.6 CDF35584.1 - 0.029 14.7 0.0 0.073 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF35584.1 - 0.077 13.5 0.1 0.21 12.1 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 CDF35584.1 - 0.078 12.7 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CDF35584.1 - 0.12 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 CDF35584.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Arf PF00025.21 CDF35584.1 - 0.18 11.2 0.0 0.43 10.0 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family DAHP_synth_2 PF01474.16 CDF35585.1 - 8.2e-188 624.3 0.0 9.4e-188 624.2 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family DUF2389 PF09493.10 CDF35586.1 - 1.5e-11 44.7 0.2 1.5e-11 44.7 0.2 1.6 2 0 0 2 2 2 1 Tryptophan-rich protein (DUF2389) DnaJ_CXXCXGXG PF00684.19 CDF35586.1 - 0.04 14.3 10.0 1.3 9.5 0.7 2.9 2 1 0 2 2 2 0 DnaJ central domain DUF1356 PF07092.12 CDF35586.1 - 0.075 12.3 2.4 1.9 7.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1356) UDG PF03167.19 CDF35587.1 - 1.4e-24 86.9 0.0 2.5e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Tristanin_u2 PF16638.5 CDF35589.1 - 9.2 7.1 10.0 20 6.0 10.0 1.5 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers XRCC1_N PF01834.16 CDF35590.1 - 0.027 14.5 0.1 0.028 14.4 0.1 1.0 1 0 0 1 1 1 0 XRCC1 N terminal domain SNF2_N PF00176.23 CDF35592.1 - 1.5e-47 162.0 0.0 2.5e-47 161.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_5 PF14634.6 CDF35592.1 - 4e-08 33.1 6.1 9.6e-08 31.9 6.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDF35592.1 - 1e-07 31.7 5.6 2e-07 30.7 5.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF35592.1 - 2e-07 30.7 6.9 4.2e-07 29.7 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF35592.1 - 3.6e-07 29.9 6.5 3.6e-07 29.9 6.5 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF35592.1 - 7.8e-07 29.3 7.2 7.8e-07 29.3 7.2 2.1 2 0 0 2 2 2 1 Ring finger domain Helicase_C PF00271.31 CDF35592.1 - 7e-06 26.4 0.0 1.8e-05 25.1 0.0 1.7 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-C3HC4_4 PF15227.6 CDF35592.1 - 6e-05 23.1 8.0 0.00014 21.9 8.0 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CDF35592.1 - 0.00012 22.0 7.5 0.00032 20.6 7.5 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDF35592.1 - 0.00017 21.4 6.2 0.00082 19.2 6.3 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CDF35592.1 - 0.00071 19.8 2.4 0.0023 18.2 2.4 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 CDF35592.1 - 0.0041 16.9 3.8 0.0096 15.7 3.8 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 CDF35592.1 - 0.02 14.8 2.8 0.05 13.5 2.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 CDF35592.1 - 0.023 14.8 1.8 0.052 13.6 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TusA PF01206.17 CDF35592.1 - 0.11 12.4 0.0 0.64 9.9 0.0 2.3 3 0 0 3 3 2 0 Sulfurtransferase TusA zf-P11 PF03854.14 CDF35592.1 - 0.36 10.5 3.5 0.91 9.2 3.5 1.7 1 0 0 1 1 1 0 P-11 zinc finger zf-Nse PF11789.8 CDF35592.1 - 1.2 9.0 5.2 5.4 6.9 5.3 2.1 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Ribosomal_L4 PF00573.22 CDF35593.1 - 6.6e-53 179.3 0.0 7.5e-53 179.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Rhomboid PF01694.22 CDF35594.1 - 3.2e-28 98.6 6.6 4.2e-28 98.3 6.6 1.1 1 0 0 1 1 1 1 Rhomboid family Glyoxalase PF00903.25 CDF35596.1 - 2.9e-08 34.0 0.0 3.8e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDF35596.1 - 1.9e-05 25.4 0.0 3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CDF35596.1 - 0.00057 19.8 0.0 0.00088 19.2 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain RNA_pol_Rpb2_3 PF04565.16 CDF35596.1 - 0.16 12.2 0.0 0.82 9.9 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 3 His_Phos_2 PF00328.22 CDF35597.1 - 1.2e-20 74.3 0.0 2.3e-20 73.3 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PseudoU_synth_1 PF01416.20 CDF35598.1 - 4.5e-30 104.3 0.0 1.1e-26 93.4 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase PPI_Ypi1 PF07491.11 CDF35599.1 - 6.9e-18 64.2 2.4 1.8e-17 62.9 2.4 1.7 1 0 0 1 1 1 1 Protein phosphatase inhibitor Acyltransferase PF01553.21 CDF35600.1 - 2.6e-12 46.5 0.0 3.9e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase GPAT_N PF14829.6 CDF35600.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal Cyclin_N PF00134.23 CDF35601.1 - 4e-11 42.8 0.0 3.6e-08 33.2 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDF35601.1 - 6.9e-07 29.4 0.0 0.0049 16.9 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain TFIIB PF00382.19 CDF35601.1 - 0.00041 20.3 0.0 0.02 15.0 0.0 2.3 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 CDF35601.1 - 0.034 14.5 0.1 0.79 10.1 0.0 2.4 2 1 0 2 2 2 0 Cyclin C-terminal domain PEMT PF04191.13 CDF35604.1 - 2.8e-28 98.4 1.6 2.8e-28 98.4 1.6 2.1 3 0 0 3 3 3 1 Phospholipid methyltransferase DEC1 PF15859.5 CDF35604.1 - 0.025 14.6 0.5 0.11 12.5 0.1 2.0 2 0 0 2 2 2 0 Deleted in esophageal cancer 1 family VirB3 PF05101.13 CDF35604.1 - 0.5 10.6 3.3 14 5.9 0.2 2.6 3 0 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein TIG PF01833.24 CDF35605.1 - 2.9e-14 52.9 4.9 1e-06 28.7 0.1 2.9 2 0 0 2 2 2 2 IPT/TIG domain PA14 PF07691.12 CDF35605.1 - 0.0011 18.7 0.0 0.0036 17.1 0.0 1.8 2 0 0 2 2 2 1 PA14 domain DHHC PF01529.20 CDF35606.1 - 7.7e-34 116.7 13.2 1.4e-33 115.8 7.0 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase PI3_PI4_kinase PF00454.27 CDF35607.1 - 1.4e-29 103.7 0.0 2.3e-24 86.6 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 CDF35607.1 - 9.1e-05 21.9 0.0 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Trypsin PF00089.26 CDF35608.1 - 3.3e-32 112.1 0.3 5.6e-32 111.3 0.3 1.4 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDF35608.1 - 9.7e-06 26.5 0.1 3.8e-05 24.6 0.0 1.9 1 1 1 2 2 2 1 Trypsin-like peptidase domain Glyco_hydro_30C PF17189.4 CDF35608.1 - 0.038 14.2 0.2 6.5 7.1 0.0 3.0 2 1 1 3 3 3 0 Glycosyl hydrolase family 30 beta sandwich domain RT_RNaseH PF17917.1 CDF35613.1 - 6e-35 119.7 0.2 3.4e-32 110.9 0.0 3.1 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF35613.1 - 3e-33 113.8 0.0 1.6e-32 111.5 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF35613.1 - 7.9e-22 77.7 0.0 1.7e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF35613.1 - 9.9e-12 44.8 0.1 2.4e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDF35613.1 - 0.00086 19.5 0.1 0.0017 18.5 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 CDF35613.1 - 0.0013 18.5 0.0 0.0034 17.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CDF35613.1 - 0.026 14.1 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TIG PF01833.24 CDF35614.1 - 1.7e-12 47.3 15.9 4.6e-07 29.8 1.5 3.9 3 0 0 3 3 3 2 IPT/TIG domain GSDH PF07995.11 CDF35614.1 - 0.0037 16.6 0.0 0.26 10.5 0.0 2.3 2 0 0 2 2 2 2 Glucose / Sorbosone dehydrogenase PTS_EIIB PF00367.20 CDF35616.1 - 0.11 12.0 0.1 0.29 10.7 0.1 1.7 1 0 0 1 1 1 0 phosphotransferase system, EIIB PRK PF00485.18 CDF35618.1 - 2.7e-44 151.3 0.9 1.4e-43 149.0 0.9 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 CDF35618.1 - 2.8e-40 138.0 0.0 4e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 CDF35618.1 - 0.00035 21.1 0.0 0.00066 20.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 CDF35618.1 - 0.0029 17.5 0.1 0.013 15.4 0.1 2.0 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CoaE PF01121.20 CDF35618.1 - 0.0072 16.0 0.5 0.061 13.0 0.2 2.1 2 0 0 2 2 2 1 Dephospho-CoA kinase AAA_17 PF13207.6 CDF35618.1 - 0.0074 16.7 1.3 0.43 11.0 0.2 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDF35618.1 - 0.047 13.0 0.0 0.2 10.9 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin Pribosyltran PF00156.27 CDF35618.1 - 0.096 12.2 0.3 0.4 10.2 0.1 2.0 2 0 0 2 2 2 0 Phosphoribosyl transferase domain MarR_2 PF12802.7 CDF35618.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_16 PF12645.7 CDF35618.1 - 0.18 11.9 0.1 0.43 10.7 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain NTPase_1 PF03266.15 CDF35618.1 - 0.2 11.5 0.5 0.5 10.3 0.3 1.8 2 0 0 2 2 2 0 NTPase ASC PF00858.24 CDF35623.1 - 0.00091 18.3 0.0 0.14 11.1 0.0 2.1 2 0 0 2 2 2 2 Amiloride-sensitive sodium channel Pkinase PF00069.25 CDF35624.1 - 6.4e-65 219.1 0.0 8.7e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35624.1 - 4e-37 127.9 0.0 5.9e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF35624.1 - 3.6e-09 35.9 0.2 7e-09 34.9 0.2 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF35624.1 - 1.1e-05 24.9 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF35624.1 - 0.00022 20.7 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF35624.1 - 0.0015 18.5 0.2 0.0062 16.5 0.2 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 CDF35624.1 - 0.008 15.8 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 CDF35626.1 - 1.2e-54 181.0 47.3 1.7e-09 38.1 0.0 12.1 12 0 0 12 12 12 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35626.1 - 1.6e-46 156.5 19.9 2.8e-05 24.3 0.0 11.6 1 1 11 12 12 12 11 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF35626.1 - 2.5e-19 69.5 0.1 5.3e-19 68.4 0.1 1.6 1 0 0 1 1 1 1 NB-ARC domain PD40 PF07676.12 CDF35626.1 - 2.7e-19 68.6 7.6 0.12 12.3 0.0 10.9 12 0 0 12 12 12 5 WD40-like Beta Propeller Repeat eIF2A PF08662.11 CDF35626.1 - 2.5e-17 63.4 0.2 0.0016 18.4 0.2 5.5 1 1 2 5 5 5 5 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDF35626.1 - 1.2e-13 50.8 0.2 0.14 11.1 0.0 6.7 2 2 5 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 CDF35626.1 - 9.6e-09 35.0 5.9 3.1 7.0 0.1 7.5 3 3 5 8 8 8 3 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 CDF35626.1 - 0.00014 20.7 6.0 5.7 5.6 0.0 7.1 5 2 2 8 8 8 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF1513 PF07433.11 CDF35626.1 - 0.026 13.6 0.6 38 3.2 0.1 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) APAF1_C PF17908.1 CDF35626.1 - 0.19 11.8 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain IKI3 PF04762.12 CDF35626.1 - 1.2 7.1 8.0 8.8 4.2 0.0 4.1 2 1 2 4 4 4 0 IKI3 family TFIIIC_delta PF12657.7 CDF35626.1 - 1.7 8.6 21.3 32 4.4 0.1 7.7 6 2 1 7 7 7 0 Transcription factor IIIC subunit delta N-term Pkinase PF00069.25 CDF35627.1 - 2.2e-63 214.1 0.0 2.7e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35627.1 - 3.5e-32 111.7 0.0 4.8e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF35627.1 - 1.3e-08 34.5 0.0 2.2e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDF35627.1 - 9.3e-08 31.3 0.6 3e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CDF35627.1 - 4.1e-05 23.0 0.0 7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF35627.1 - 0.039 13.9 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RVT_3 PF13456.6 CDF35631.1 - 0.056 13.3 0.6 0.76 9.6 0.0 2.7 2 1 0 2 2 2 0 Reverse transcriptase-like CENP-B_N PF04218.13 CDF35634.1 - 0.033 13.8 1.4 0.052 13.2 1.4 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 CDF35634.1 - 0.047 13.5 0.2 0.099 12.5 0.1 1.6 1 1 0 1 1 1 0 Homeodomain-like domain MRP-L46 PF11788.8 CDF35635.1 - 7.7e-06 26.7 0.7 0.0041 17.9 0.1 2.3 1 1 1 2 2 2 2 39S mitochondrial ribosomal protein L46 Oxysterol_BP PF01237.18 CDF35638.1 - 1e-103 347.1 0.0 2e-102 342.9 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Oxysterol_BP PF01237.18 CDF35640.1 - 3.7e-109 365.0 3.2 2.2e-108 362.5 3.2 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 CDF35640.1 - 6.1e-10 39.6 0.1 2e-09 37.9 0.0 1.9 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 CDF35640.1 - 8.4e-08 32.4 0.0 1.7e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 CDF35640.1 - 0.0014 18.9 0.0 0.0056 17.0 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 CDF35640.1 - 0.072 12.9 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Las1 PF04031.13 CDF35642.1 - 6.3e-32 110.8 1.0 1.1e-31 110.0 1.0 1.4 1 0 0 1 1 1 1 Las1-like GSHPx PF00255.19 CDF35643.1 - 5.1e-31 106.5 0.0 6.9e-31 106.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 CDF35643.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family SAP PF02037.27 CDF35644.1 - 3.7e-10 39.3 0.6 8.2e-10 38.2 0.6 1.6 1 0 0 1 1 1 1 SAP domain SseC PF04888.12 CDF35644.1 - 0.033 13.8 0.5 0.057 13.0 0.5 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Transposase_24 PF03004.14 CDF35644.1 - 0.41 10.7 2.0 1.2 9.2 0.4 2.4 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) HEAT_2 PF13646.6 CDF35645.1 - 3e-22 78.8 25.4 1.4e-09 38.2 0.7 3.2 1 1 3 4 4 4 4 HEAT repeats HEAT_EZ PF13513.6 CDF35645.1 - 8e-07 29.4 12.1 0.0055 17.2 0.1 5.2 3 2 3 6 6 6 4 HEAT-like repeat HEAT PF02985.22 CDF35645.1 - 9.5e-07 28.6 8.7 0.061 13.6 0.0 5.2 5 2 0 5 5 5 3 HEAT repeat HEAT_PBS PF03130.16 CDF35645.1 - 0.0011 19.4 15.8 1.4 9.8 0.0 6.6 8 0 0 8 8 8 2 PBS lyase HEAT-like repeat Arm PF00514.23 CDF35645.1 - 0.023 14.7 6.0 0.4 10.8 0.0 4.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 CDF35645.1 - 0.025 13.7 0.0 0.16 11.0 0.0 2.2 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Vitellogenin_N PF01347.22 CDF35645.1 - 0.17 10.3 0.1 5.1 5.4 0.0 2.1 2 0 0 2 2 2 0 Lipoprotein amino terminal region Fer4_13 PF13370.6 CDF35647.1 - 2.1e-09 37.8 0.5 4.7e-09 36.6 0.5 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 CDF35647.1 - 8.2e-05 23.3 3.5 0.0001 22.9 1.4 2.4 2 1 0 2 2 2 1 4Fe-4S single cluster domain Fer4_7 PF12838.7 CDF35647.1 - 0.052 14.2 4.9 0.35 11.5 0.1 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDF35647.1 - 0.26 11.5 0.1 0.26 11.5 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain WD40 PF00400.32 CDF35648.1 - 6.5e-54 178.7 25.5 1.5e-11 44.6 0.1 10.5 11 0 0 11 11 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35648.1 - 1.6e-22 79.6 2.7 0.0062 16.8 0.0 8.8 4 3 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF35648.1 - 2.6e-14 53.0 0.0 4.7e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain APAF1_C PF17908.1 CDF35648.1 - 0.00039 20.4 1.7 0.00061 19.8 0.3 2.0 2 0 0 2 2 2 1 APAF-1 helical domain Nup160 PF11715.8 CDF35648.1 - 0.00061 18.6 5.0 0.56 8.8 0.1 4.2 5 0 0 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 CDF35648.1 - 0.00083 19.3 0.0 0.21 11.5 0.0 3.0 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A AAA_22 PF13401.6 CDF35648.1 - 0.0017 18.6 0.0 0.0044 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Nbas_N PF15492.6 CDF35648.1 - 0.0034 16.8 0.1 1.4 8.2 0.0 3.3 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 CDF35648.1 - 0.034 13.1 0.0 2.5 7.0 0.0 3.6 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF35648.1 - 0.059 13.9 0.1 36 5.0 0.0 4.2 4 0 0 4 4 4 0 PQQ-like domain AAA_16 PF13191.6 CDF35648.1 - 0.066 13.6 0.6 0.17 12.3 0.1 1.9 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDF35648.1 - 0.084 13.0 0.0 0.29 11.2 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 CDF35648.1 - 0.16 12.5 0.1 0.49 10.9 0.0 1.8 2 0 0 2 2 2 0 ABC transporter DUF87 PF01935.17 CDF35648.1 - 0.49 10.5 3.2 0.26 11.4 0.4 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain DUF1995 PF09353.10 CDF35649.1 - 3e-12 47.0 0.0 4.9e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) ERCC4 PF02732.15 CDF35650.1 - 7.8e-14 52.2 0.0 1.4e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain Ribosomal_60s PF00428.19 CDF35651.1 - 7.8e-20 71.3 7.5 9e-20 71.1 7.5 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L11_N PF03946.14 CDF35652.1 - 6.9e-20 70.7 0.2 2e-19 69.2 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDF35652.1 - 2.9e-17 62.9 0.2 4.9e-17 62.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Fe_bilin_red PF05996.12 CDF35653.1 - 2.1e-75 253.3 0.0 2.5e-75 253.1 0.0 1.0 1 0 0 1 1 1 1 Ferredoxin-dependent bilin reductase B12-binding_2 PF02607.17 CDF35653.1 - 0.14 12.6 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain DEAD PF00270.29 CDF35654.1 - 3.5e-49 166.9 0.0 6.3e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF35654.1 - 4.8e-29 100.9 0.0 1.3e-28 99.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDF35654.1 - 0.00012 21.4 0.0 0.00019 20.7 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CDF35654.1 - 0.0013 18.8 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Nitroreductase PF00881.24 CDF35654.1 - 0.068 13.2 0.0 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 Nitroreductase family AAA_22 PF13401.6 CDF35654.1 - 0.64 10.3 2.4 1.4 9.2 0.6 2.4 2 1 0 2 2 2 0 AAA domain DUF1744 PF08490.12 CDF35655.1 - 2e-87 293.4 0.0 3.4e-87 292.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 CDF35655.1 - 7.3e-56 189.7 0.0 1.5e-55 188.7 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 CDF35655.1 - 8.2e-17 61.0 0.1 8.5e-16 57.7 0.1 2.4 2 1 0 2 2 2 1 DNA polymerase family B RNase_H_2 PF13482.6 CDF35655.1 - 4.9e-08 33.1 0.0 4.7e-07 30.0 0.0 2.4 2 0 0 2 2 2 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 CDF35655.1 - 2.5e-06 27.3 0.1 8.1e-06 25.7 0.1 1.7 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB TGT PF01702.18 CDF35656.1 - 8.6e-96 321.1 0.0 1e-95 320.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF4250 PF14056.6 CDF35657.1 - 0.78 9.7 3.9 1.5 8.8 0.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4250) Atg14 PF10186.9 CDF35657.1 - 1 8.4 7.2 1.2 8.2 7.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Gp_dh_C PF02800.20 CDF35658.1 - 1.3e-62 210.0 0.1 2.5e-62 209.1 0.1 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDF35658.1 - 7.2e-35 119.4 0.4 1.6e-34 118.3 0.2 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 CDF35658.1 - 0.011 15.5 0.1 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AAA PF00004.29 CDF35659.1 - 5.3e-45 153.1 0.0 8.9e-43 145.9 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF35659.1 - 2.5e-05 24.7 0.6 0.0045 17.4 0.1 2.9 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 CDF35659.1 - 0.0003 20.6 0.0 0.00072 19.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDF35659.1 - 0.00055 20.0 0.0 0.003 17.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDF35659.1 - 0.0014 18.8 0.0 0.0038 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDF35659.1 - 0.011 15.1 0.1 0.051 13.0 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CDF35659.1 - 0.016 14.5 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_22 PF13401.6 CDF35659.1 - 0.016 15.5 0.1 0.088 13.1 0.1 2.1 1 1 1 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CDF35659.1 - 0.025 14.3 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CDF35659.1 - 0.028 15.0 0.0 0.055 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CDF35659.1 - 0.03 14.4 0.0 0.16 12.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) Vps4_C PF09336.10 CDF35659.1 - 0.033 14.2 0.0 0.31 11.1 0.0 2.4 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain TsaE PF02367.17 CDF35659.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CDF35659.1 - 0.097 12.9 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDF35659.1 - 0.11 12.8 0.0 0.31 11.5 0.0 1.7 2 0 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.26 CDF35659.1 - 0.13 12.0 0.0 0.52 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 CDF35659.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Fer2_4 PF13510.6 CDF35660.1 - 5.8e-19 67.9 1.0 1.1e-18 67.0 1.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 CDF35660.1 - 6.8e-16 57.5 0.1 6.8e-16 57.5 0.1 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 CDF35660.1 - 3.6e-09 36.4 1.1 3.6e-09 36.4 1.1 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.27 CDF35660.1 - 0.071 13.0 1.6 2.3 8.1 0.4 3.0 2 0 0 2 2 2 0 4Fe-4S binding domain Med31 PF05669.12 CDF35661.1 - 2.7e-06 27.3 0.1 3.7e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 SOH1 Patatin PF01734.22 CDF35662.1 - 6.5e-12 46.1 0.0 6.2e-11 42.9 0.0 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase VHL PF01847.16 CDF35663.1 - 8e-16 57.7 0.2 1.2e-15 57.1 0.2 1.3 1 0 0 1 1 1 1 VHL beta domain Arm PF00514.23 CDF35664.1 - 3.5e-05 23.7 3.4 21 5.4 0.0 6.3 5 1 1 6 6 6 3 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 CDF35664.1 - 0.0043 17.0 8.2 3.9 7.6 0.1 4.4 4 0 0 4 4 4 3 Spinocerebellar ataxia type 10 protein domain DUF4957 PF16318.5 CDF35664.1 - 0.057 13.4 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4957) Hydrolase_4 PF12146.8 CDF35665.1 - 1.2e-09 37.8 0.1 0.00033 20.0 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CDF35665.1 - 6.4e-07 29.1 0.0 2.2e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CDF35665.1 - 0.00027 21.6 0.0 0.0011 19.6 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CDF35665.1 - 0.002 17.7 0.0 1.9 8.0 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family DUF3046 PF11248.8 CDF35665.1 - 0.0022 18.3 0.1 0.0067 16.8 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3046) Abhydrolase_1 PF00561.20 CDF35665.1 - 0.008 15.8 0.0 0.053 13.2 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CDF35665.1 - 0.024 14.5 0.0 0.06 13.2 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDF35665.1 - 0.042 13.6 0.0 0.15 11.9 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Ndr PF03096.14 CDF35665.1 - 0.046 12.4 0.0 0.067 11.9 0.0 1.2 1 0 0 1 1 1 0 Ndr family LIDHydrolase PF10230.9 CDF35665.1 - 0.11 12.0 0.0 0.33 10.5 0.0 1.6 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Sec1 PF00995.23 CDF35666.1 - 6.9e-115 385.5 0.0 8.6e-115 385.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family ETF_QO PF05187.13 CDF35667.1 - 2.1e-45 153.1 0.1 3.3e-45 152.5 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 CDF35667.1 - 1.6e-08 34.1 1.1 9e-05 21.7 1.1 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CDF35667.1 - 1.8e-08 33.9 0.0 5e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 CDF35667.1 - 3.6e-08 33.4 0.6 0.00029 20.5 0.5 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDF35667.1 - 1.2e-07 31.9 0.0 8.1e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CDF35667.1 - 1e-05 25.0 0.0 1.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CDF35667.1 - 1.1e-05 24.8 0.0 6.1e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF35667.1 - 7.4e-05 21.6 0.1 0.00012 20.9 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CDF35667.1 - 0.00016 22.2 0.1 0.63 10.6 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDF35667.1 - 0.00019 20.6 0.1 0.0003 19.9 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 CDF35667.1 - 0.00023 21.2 0.1 0.00042 20.3 0.1 1.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CDF35667.1 - 0.0018 17.6 0.1 0.0027 17.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CDF35667.1 - 0.0028 16.6 0.1 0.29 9.9 0.1 2.3 2 0 0 2 2 2 1 Tryptophan halogenase K_oxygenase PF13434.6 CDF35667.1 - 0.0067 15.6 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Fer4_7 PF12838.7 CDF35667.1 - 0.0086 16.7 1.2 0.021 15.4 1.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain FAD_oxidored PF12831.7 CDF35667.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 CDF35667.1 - 0.17 11.0 0.2 0.25 10.4 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A PB1 PF00564.24 CDF35668.1 - 7e-15 54.7 0.4 1.1e-14 54.1 0.4 1.3 1 0 0 1 1 1 1 PB1 domain PB1 PF00564.24 CDF35669.1 - 9e-13 48.0 0.1 2e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 PB1 domain GATA PF00320.27 CDF35669.1 - 0.005 16.4 3.4 0.011 15.3 3.4 1.5 1 0 0 1 1 1 1 GATA zinc finger PIF1 PF05970.14 CDF35670.1 - 1.7e-78 264.3 0.1 2.5e-50 171.7 0.0 2.7 1 1 2 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 CDF35670.1 - 1e-11 44.9 0.0 2.1e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF35670.1 - 0.0096 16.3 0.0 0.033 14.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDF35670.1 - 0.023 14.5 0.1 7.7 6.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 CDF35670.1 - 0.063 13.1 0.1 0.21 11.4 0.1 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 CDF35670.1 - 0.23 9.3 0.0 0.41 8.5 0.0 1.3 1 0 0 1 1 1 0 Helicase TIP49 PF06068.13 CDF35671.1 - 2.1e-91 306.8 3.6 9.1e-46 156.7 1.7 2.1 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 CDF35671.1 - 2.4e-09 37.2 0.3 7.7e-09 35.6 0.2 2.0 2 0 0 2 2 1 1 TIP49 AAA-lid domain DnaB_C PF03796.15 CDF35671.1 - 9.5e-06 25.1 0.4 2e-05 24.1 0.4 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA PF00004.29 CDF35671.1 - 1.1e-05 25.9 0.7 0.00096 19.6 0.2 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDF35671.1 - 0.00017 21.5 0.2 0.0011 18.9 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 CDF35671.1 - 0.00019 21.4 0.1 0.068 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CDF35671.1 - 0.00037 20.1 0.1 0.0049 16.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDF35671.1 - 0.00045 20.6 0.1 0.0019 18.6 0.1 2.0 2 1 0 2 2 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CDF35671.1 - 0.0037 16.7 0.6 0.11 11.9 0.2 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CDF35671.1 - 0.009 16.4 3.4 0.041 14.2 3.4 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CDF35671.1 - 0.0092 15.7 0.4 3.4 7.4 0.1 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 CDF35671.1 - 0.013 14.8 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 CDF35671.1 - 0.015 15.6 0.6 1.5 9.1 0.6 2.5 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CDF35671.1 - 0.019 14.7 0.1 8 6.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 CDF35671.1 - 0.024 14.1 0.2 0.047 13.1 0.2 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 CDF35671.1 - 0.038 13.5 0.1 0.22 11.0 0.1 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2075 PF09848.9 CDF35671.1 - 0.06 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 CDF35671.1 - 0.069 13.2 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDF35671.1 - 0.079 12.7 4.2 0.61 9.8 4.2 2.1 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDF35671.1 - 0.11 11.8 0.3 0.22 10.8 0.3 1.4 1 0 0 1 1 1 0 Zeta toxin CbiA PF01656.23 CDF35671.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_11 PF13086.6 CDF35671.1 - 0.12 12.1 0.1 0.26 11.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDF35671.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain APH PF01636.23 CDF35672.1 - 0.00011 22.2 1.8 0.00011 22.2 1.8 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Retrotran_gag_2 PF14223.6 CDF35678.1 - 2e-33 115.0 0.4 3.9e-33 114.0 0.0 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF35678.1 - 8.5e-12 45.3 0.9 2.4e-11 43.8 0.0 2.3 3 0 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 CDF35678.1 - 2e-07 30.8 0.0 1.3e-06 28.2 0.0 2.3 2 0 0 2 2 2 1 GAG-pre-integrase domain zf-CCHC_4 PF14392.6 CDF35678.1 - 0.033 13.9 1.1 0.11 12.3 1.1 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF35678.1 - 0.23 11.6 4.0 0.42 10.8 4.0 1.4 1 0 0 1 1 1 0 Zinc knuckle An_peroxidase PF03098.15 CDF35679.1 - 2.1e-120 402.8 0.0 2.5e-120 402.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase DUF2428 PF10350.9 CDF35681.1 - 5.4e-43 147.2 4.1 5.4e-43 147.2 0.5 2.8 4 0 0 4 4 4 1 Putative death-receptor fusion protein (DUF2428) HEAT_EZ PF13513.6 CDF35681.1 - 0.018 15.6 0.1 3.1 8.4 0.0 4.3 3 0 0 3 3 3 0 HEAT-like repeat Castor_Poll_mid PF06241.12 CDF35684.1 - 4.2e-11 42.7 0.0 0.00028 20.8 0.0 2.6 2 0 0 2 2 2 2 Castor and Pollux, part of voltage-gated ion channel Cupin_4 PF08007.12 CDF35685.1 - 2e-50 172.1 0.0 2.7e-50 171.6 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 CDF35685.1 - 2.8e-07 30.5 0.0 1.1e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 CDF35685.1 - 0.16 11.7 0.0 0.44 10.3 0.0 1.7 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 CDF35685.1 - 0.18 11.4 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Cupin Isochorismatase PF00857.20 CDF35686.1 - 1.5e-35 123.0 0.0 2e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family DUF2205 PF10224.9 CDF35687.1 - 0.0066 16.4 2.7 0.0068 16.4 0.5 2.1 1 1 1 2 2 2 1 Short coiled-coil protein Macoilin PF09726.9 CDF35687.1 - 0.075 11.6 6.9 0.098 11.2 6.9 1.1 1 0 0 1 1 1 0 Macoilin family DUF4200 PF13863.6 CDF35687.1 - 0.086 13.2 4.2 6.1 7.3 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF655 PF04919.12 CDF35687.1 - 0.1 12.5 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF655) SYCE1 PF15233.6 CDF35687.1 - 0.12 12.5 9.1 0.058 13.4 5.4 2.1 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 HALZ PF02183.18 CDF35687.1 - 0.22 11.8 0.2 0.22 11.8 0.2 2.3 2 1 1 3 3 3 0 Homeobox associated leucine zipper JIP_LZII PF16471.5 CDF35687.1 - 0.96 9.7 5.6 0.5 10.6 1.0 2.8 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II TolA_bind_tri PF16331.5 CDF35687.1 - 1 9.5 9.9 0.21 11.7 1.0 2.9 2 1 0 3 3 3 0 TolA binding protein trimerisation Tropomyosin_1 PF12718.7 CDF35687.1 - 2.1 8.5 8.4 4.3 7.5 7.3 2.0 1 1 1 2 2 2 0 Tropomyosin like SlyX PF04102.12 CDF35687.1 - 4.7 7.9 8.8 0.29 11.8 0.7 2.6 2 1 1 3 3 3 0 SlyX Aconitase PF00330.20 CDF35688.1 - 2.7e-79 267.3 0.1 4e-77 260.2 0.1 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) PBS_linker_poly PF00427.21 CDF35689.1 - 6.2e-32 110.3 0.4 9.5e-32 109.7 0.4 1.2 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide CpcD PF01383.21 CDF35689.1 - 8.8e-15 54.7 0.1 6.8e-11 42.3 0.0 2.6 1 1 1 2 2 2 2 CpcD/allophycocyanin linker domain Aldo_ket_red PF00248.21 CDF35690.1 - 4.4e-49 167.2 0.0 5.2e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GCSF PF16647.5 CDF35690.1 - 0.095 12.5 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Granulocyte colony-stimulating factor Aldo_ket_red PF00248.21 CDF35691.1 - 6.3e-57 193.0 0.0 7.2e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HCV_core PF01542.18 CDF35691.1 - 0.056 13.8 0.1 0.16 12.4 0.0 1.8 2 0 0 2 2 2 0 Hepatitis C virus core protein B-block_TFIIIC PF04182.12 CDF35692.1 - 0.00021 21.4 0.0 0.0011 19.1 0.0 2.4 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC dsRBD2 PF17842.1 CDF35693.1 - 0.061 13.5 0.3 0.071 13.3 0.3 1.2 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 DHHC PF01529.20 CDF35694.1 - 1.7e-30 105.9 18.6 1.7e-30 105.9 18.6 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase DAP3 PF10236.9 CDF35695.1 - 1.5e-18 67.0 0.0 3.2e-18 66.0 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CDF35695.1 - 3.5e-07 30.8 0.0 1.6e-06 28.6 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA-ATPase_like PF09820.9 CDF35695.1 - 0.00031 20.3 0.0 0.00046 19.7 0.0 1.3 1 0 0 1 1 1 1 Predicted AAA-ATPase AAA_22 PF13401.6 CDF35695.1 - 0.00047 20.4 0.0 0.12 12.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDF35695.1 - 0.058 13.0 0.1 6.4 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDF35695.1 - 0.097 12.7 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CDF35695.1 - 0.13 12.7 0.1 2.1 8.8 0.1 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDF35695.1 - 0.15 12.0 0.4 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_35 PF14516.6 CDF35695.1 - 0.16 10.7 0.0 1.6 7.5 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_14 PF13173.6 CDF35695.1 - 0.19 11.8 0.0 0.75 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CDF35695.1 - 0.22 11.4 0.0 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Adap_comp_sub PF00928.21 CDF35696.1 - 5.1e-53 180.1 0.0 6.3e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDF35696.1 - 2.9e-07 30.5 0.0 5.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain FhuF PF06276.12 CDF35696.1 - 0.14 12.6 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Ferric iron reductase FhuF-like transporter DUF1754 PF08555.10 CDF35697.1 - 0.00019 22.1 0.1 0.00019 22.1 0.1 1.8 2 0 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) FlaC_arch PF05377.11 CDF35698.1 - 0.003 17.9 11.6 0.0042 17.4 0.5 4.8 5 1 1 6 6 6 1 Flagella accessory protein C (FlaC) Bap31_Bap29_C PF18035.1 CDF35698.1 - 0.0057 16.6 5.3 0.0057 16.6 5.3 4.8 6 0 0 6 6 5 1 Bap31/Bap29 cytoplasmic coiled-coil domain Spc7 PF08317.11 CDF35698.1 - 0.028 13.3 28.4 0.0078 15.1 10.6 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein GNVR PF13807.6 CDF35698.1 - 0.091 12.7 0.7 0.2 11.6 0.7 1.5 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase Baculo_PEP_C PF04513.12 CDF35698.1 - 0.1 12.6 1.2 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Golgin_A5 PF09787.9 CDF35698.1 - 0.25 10.8 27.1 0.46 9.9 9.5 3.2 3 0 0 3 3 3 0 Golgin subfamily A member 5 Syntaxin_2 PF14523.6 CDF35698.1 - 0.25 11.7 0.1 0.25 11.7 0.1 3.6 3 1 0 3 3 3 0 Syntaxin-like protein DUF641 PF04859.12 CDF35698.1 - 0.3 11.4 25.9 0.86 9.9 6.2 4.1 3 2 0 3 3 3 0 Plant protein of unknown function (DUF641) DUF724 PF05266.14 CDF35698.1 - 0.98 9.2 29.7 0.034 14.0 5.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF724) KxDL PF10241.9 CDF35698.1 - 1.8 8.9 21.3 0.88 9.9 1.1 4.4 3 2 1 4 4 4 0 Uncharacterized conserved protein HrpB7 PF09486.10 CDF35698.1 - 3.1 8.2 30.7 0.13 12.6 0.5 3.9 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) Atg14 PF10186.9 CDF35698.1 - 4.7 6.2 30.4 0.11 11.6 8.0 3.0 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5082 PF16888.5 CDF35698.1 - 5.1 7.4 15.7 0.093 13.0 2.5 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 CDF35698.1 - 6.3 7.3 34.9 20 5.7 6.7 3.6 2 1 0 2 2 2 0 Apg6 coiled-coil region Bacillus_HBL PF05791.11 CDF35698.1 - 6.8 6.5 8.1 3.7 7.3 0.5 2.9 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) PKcGMP_CC PF16808.5 CDF35698.1 - 7.9 6.4 11.0 25 4.8 4.5 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YabA PF06156.13 CDF35698.1 - 9.9 6.9 16.9 3.3 8.4 1.4 4.2 3 1 1 4 4 4 0 Initiation control protein YabA UPF0054 PF02130.17 CDF35699.1 - 2.6e-29 101.6 0.1 3.6e-29 101.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 eIF-3_zeta PF05091.12 CDF35701.1 - 6e-160 533.7 0.0 7.4e-160 533.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PT-VENN PF04829.13 CDF35704.1 - 0.06 13.4 2.5 0.66 10.1 0.0 2.5 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif Peptidase_C78 PF07910.13 CDF35705.1 - 2.3e-38 131.8 0.0 3.1e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 Rad50_zn_hook PF04423.14 CDF35705.1 - 0.098 12.5 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif NMT PF01233.19 CDF35707.1 - 7.4e-22 77.9 0.1 7.7e-22 77.8 0.1 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain RNA_pol_A_bac PF01000.26 CDF35709.1 - 1e-21 77.4 0.0 2.7e-21 76.1 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CDF35709.1 - 5.5e-21 73.8 0.0 7.6e-21 73.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain NPL PF17800.1 CDF35709.1 - 0.16 12.5 0.0 13 6.4 0.0 2.4 2 0 0 2 2 2 0 Nucleoplasmin-like domain Spt5_N PF11942.8 CDF35710.1 - 0.046 14.7 5.8 0.064 14.3 5.8 1.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.14 CDF35710.1 - 0.085 11.1 3.6 0.094 11.0 3.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Ssu72 PF04722.13 CDF35711.1 - 4.3e-66 222.1 0.0 5e-66 221.9 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein TAF6_C PF07571.13 CDF35712.1 - 1.1e-22 80.2 0.0 2.4e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 CDF35712.1 - 3.4e-14 52.8 0.0 8.2e-14 51.5 0.0 1.7 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) SCO1-SenC PF02630.14 CDF35714.1 - 2e-40 137.8 0.0 3.1e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC adh_short_C2 PF13561.6 CDF35715.1 - 4e-65 219.7 4.4 4.9e-65 219.3 4.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDF35715.1 - 5.7e-64 215.2 5.4 6.7e-64 215.0 5.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDF35715.1 - 2.1e-18 66.9 3.3 2.8e-18 66.5 3.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDF35715.1 - 0.0044 16.5 0.2 0.01 15.3 0.1 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PALP PF00291.25 CDF35715.1 - 0.021 14.2 4.0 0.018 14.5 2.9 1.4 1 1 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme NmrA PF05368.13 CDF35715.1 - 0.17 11.4 1.2 0.29 10.6 1.2 1.3 1 0 0 1 1 1 0 NmrA-like family PBS_linker_poly PF00427.21 CDF35717.1 - 1.2e-35 122.3 1.1 2.1e-35 121.5 0.2 1.8 2 0 0 2 2 2 1 Phycobilisome Linker polypeptide DUF4214 PF13946.6 CDF35717.1 - 0.024 14.7 0.6 0.087 12.9 0.1 2.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4214) TetR PF13972.6 CDF35717.1 - 0.057 13.1 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial transcriptional repressor Bcr-Abl_Oligo PF09036.10 CDF35717.1 - 0.27 11.3 0.5 0.69 10.0 0.1 1.8 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain EF_TS PF00889.19 CDF35718.1 - 2.4e-42 144.9 0.0 3.4e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor TS DUF2150 PF09920.9 CDF35718.1 - 0.08 12.9 0.6 0.43 10.5 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) Gly-zipper_OmpA PF13436.6 CDF35718.1 - 0.56 10.0 6.9 0.46 10.3 3.7 2.3 2 0 0 2 2 2 0 Glycine-zipper domain GTP_EFTU PF00009.27 CDF35719.1 - 4.3e-51 173.2 0.0 1.1e-50 171.8 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDF35719.1 - 9.2e-17 60.9 0.0 2.6e-16 59.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF35719.1 - 1.7e-08 34.7 0.3 5.6e-08 33.1 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF35719.1 - 1.8e-05 24.8 0.0 4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDF35719.1 - 2.5e-05 24.3 0.0 6.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II FeoB_N PF02421.18 CDF35719.1 - 0.054 13.0 0.1 0.23 11.0 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF5419 PF17441.2 CDF35719.1 - 0.11 12.6 0.0 2.8 8.1 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5419) APC1_C PF18122.1 CDF35720.1 - 6.5e-15 55.5 0.3 1.6e-14 54.2 0.1 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex sub unit 1 C-terminal domain Ribosomal_S18 PF01084.20 CDF35721.1 - 2.3e-15 56.6 0.2 3.8e-15 55.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 LPD18 PF18832.1 CDF35721.1 - 0.039 14.0 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 18 Stealth_CR3 PF17102.5 CDF35721.1 - 0.35 10.8 1.6 14 5.7 0.6 2.5 2 0 0 2 2 2 0 Stealth protein CR3, conserved region 3 TFIIB PF00382.19 CDF35724.1 - 3.7e-13 49.3 0.1 2.5e-12 46.7 0.0 2.2 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_N PF00134.23 CDF35724.1 - 0.0023 17.7 0.3 2.5 7.8 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Mak10 PF04112.13 CDF35725.1 - 1.8e-27 95.9 1.7 1e-23 83.7 0.2 2.7 1 1 1 2 2 2 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase WD40 PF00400.32 CDF35726.1 - 6.9e-43 143.8 26.9 1.5e-08 35.2 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35726.1 - 1.1e-20 73.7 6.4 0.00015 22.0 0.3 6.3 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF35726.1 - 0.00011 21.6 0.0 0.0065 15.8 0.0 2.3 1 1 1 2 2 2 2 WD40-like domain Nucleoporin_N PF08801.11 CDF35726.1 - 0.34 9.6 2.5 11 4.6 0.1 2.5 2 1 0 2 2 2 0 Nup133 N terminal like TRAPPC10 PF12584.8 CDF35728.1 - 3.4e-07 30.1 0.0 7.6e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Ribosomal_60s PF00428.19 CDF35729.1 - 1.2e-23 83.5 9.6 1.5e-23 83.1 9.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 CDF35729.1 - 0.1 13.0 1.5 0.15 12.5 0.1 1.8 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) NIF PF03031.18 CDF35730.1 - 1.4e-25 89.9 0.1 2e-25 89.4 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 CDF35730.1 - 0.00079 19.1 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family DEK_C PF08766.11 CDF35731.1 - 0.00055 19.8 0.8 0.0035 17.2 0.4 2.5 3 0 0 3 3 3 1 DEK C terminal domain FAM176 PF14851.6 CDF35731.1 - 1 9.0 3.4 16 5.2 0.0 2.5 2 0 0 2 2 2 0 FAM176 family DUF565 PF04483.12 CDF35732.1 - 1.3e-15 57.7 0.2 2.8e-15 56.6 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF565) DUF3955 PF13127.6 CDF35732.1 - 0.01 15.7 1.0 0.021 14.6 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) Histone PF00125.24 CDF35733.1 - 3.5e-39 134.2 0.5 5e-39 133.7 0.3 1.4 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDF35733.1 - 4.4e-05 23.6 0.0 7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 CDF35733.1 - 0.0087 16.3 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 CDF35733.1 - 0.052 13.9 0.1 0.079 13.3 0.1 1.3 1 0 0 1 1 1 0 CENP-S protein TAF PF02969.17 CDF35733.1 - 0.12 12.6 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) HMGL-like PF00682.19 CDF35734.1 - 1.6e-97 326.2 3.5 3e-97 325.3 1.2 2.1 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 CDF35734.1 - 3.7e-31 107.8 3.9 7e-31 106.9 3.9 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Myb_DNA-bind_2 PF08914.11 CDF35739.1 - 0.04 14.1 0.1 0.1 12.8 0.1 1.7 1 0 0 1 1 1 0 Rap1 Myb domain Caldesmon PF02029.15 CDF35739.1 - 3.2 6.4 32.2 4.3 6.0 32.2 1.1 1 0 0 1 1 1 0 Caldesmon MscS_TM PF12794.7 CDF35739.1 - 3.7 6.3 9.6 7.8 5.3 9.6 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Metalloenzyme PF01676.18 CDF35744.1 - 3e-30 105.4 0.0 3.2e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CDF35744.1 - 6.7e-26 91.1 1.7 2.4e-25 89.3 0.1 2.0 2 0 0 2 2 2 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 CDF35744.1 - 5.7e-05 22.9 0.0 7.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PIG-L PF02585.17 CDF35744.1 - 0.028 15.0 0.0 0.043 14.4 0.0 1.4 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase Glyco_hydro_4 PF02056.16 CDF35744.1 - 0.082 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase PglZ PF08665.12 CDF35744.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 PglZ domain PIF1 PF05970.14 CDF35745.1 - 1.8e-83 280.7 0.0 1.8e-82 277.4 0.0 2.0 1 1 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF35745.1 - 1.1e-43 149.7 0.3 3.3e-38 131.8 0.0 2.5 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF35745.1 - 7.8e-13 48.6 0.0 1.6e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF35745.1 - 0.004 17.5 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDF35745.1 - 0.033 14.0 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 CDF35745.1 - 0.049 11.6 0.0 0.079 10.9 0.0 1.2 1 0 0 1 1 1 0 Helicase VPS13 PF16908.5 CDF35747.1 - 0.0012 18.7 0.7 0.013 15.3 0.3 2.6 2 1 1 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal Aldose_epim PF01263.20 CDF35749.1 - 5.9e-43 147.3 0.0 7.2e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase UPF0242 PF06785.11 CDF35750.1 - 0.001 19.2 11.9 0.001 19.2 11.9 14.7 1 1 13 14 14 14 5 Uncharacterised protein family (UPF0242) N-terminus BLOC1_2 PF10046.9 CDF35750.1 - 0.0036 17.6 6.6 0.0036 17.6 6.6 17.6 5 3 12 21 21 21 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc42p PF11544.8 CDF35750.1 - 0.012 15.5 1.8 0.012 15.5 1.8 11.7 11 3 4 15 15 15 0 Spindle pole body component Spc42p zinc_ribbon_6 PF14599.6 CDF35751.1 - 1.1e-18 67.0 6.6 1.1e-18 67.0 6.6 5.0 3 1 3 6 6 6 1 Zinc-ribbon zf-CHY PF05495.12 CDF35751.1 - 1.8e-16 60.4 22.2 1.8e-16 60.4 22.2 3.9 2 1 0 2 2 2 1 CHY zinc finger zf-RING_2 PF13639.6 CDF35751.1 - 1.4e-08 34.9 5.4 1.4e-08 34.9 5.4 5.2 4 1 1 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 CDF35751.1 - 1.4e-06 28.1 8.1 1.4e-06 28.1 8.1 6.8 3 2 3 6 6 6 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDF35751.1 - 4.6e-06 26.4 7.7 4.6e-06 26.4 7.7 5.4 3 1 3 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF35751.1 - 0.02 15.2 13.2 0.02 15.2 13.2 4.8 2 1 3 5 5 5 0 RING-H2 zinc finger domain Hexapep PF00132.24 CDF35752.1 - 3.9e-15 54.9 18.0 1.8e-10 40.1 5.5 4.7 4 1 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDF35752.1 - 1.3e-14 53.6 15.4 6.7e-11 41.8 5.4 3.8 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 CDF35752.1 - 6.2e-13 48.8 0.0 9e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Maltose acetyltransferase DUF2613 PF11021.8 CDF35752.1 - 1.1 9.4 7.2 0.26 11.4 3.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) eIF-1a PF01176.19 CDF35753.1 - 1.7e-11 43.8 0.3 2.4e-11 43.2 0.3 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 SQHop_cyclase_C PF13243.6 CDF35754.1 - 2.6e-53 181.2 0.2 6.7e-48 163.4 1.3 2.4 2 1 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CDF35754.1 - 3.1e-44 151.2 4.4 2.6e-36 125.2 0.0 4.8 3 1 1 5 5 5 4 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 CDF35754.1 - 1e-34 117.9 11.0 9.3e-11 41.3 0.0 7.4 7 0 0 7 7 7 4 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 CDF35754.1 - 0.00032 19.8 0.4 3.8 6.5 0.0 4.3 2 1 2 4 4 4 3 A-macroglobulin TED domain Pec_lyase PF09492.10 CDF35754.1 - 0.011 15.0 0.3 15 4.8 0.0 4.0 4 1 0 4 4 4 0 Pectic acid lyase Lactamase_B_2 PF12706.7 CDF35758.1 - 2.3e-21 76.3 0.0 3.7e-19 69.0 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDF35758.1 - 2.4e-10 40.5 0.1 1.3e-09 38.2 0.0 2.0 2 1 0 2 2 2 1 Beta-lactamase superfamily domain SH2_2 PF14633.6 CDF35759.1 - 8.5e-36 123.4 0.0 1.8e-35 122.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain HHH_7 PF14635.6 CDF35759.1 - 1.4e-16 60.7 0.0 1.3e-15 57.6 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HTH_44 PF14641.6 CDF35759.1 - 1.2e-12 48.3 0.1 2.2e-08 34.6 0.0 2.5 2 0 0 2 2 2 2 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 CDF35759.1 - 1.1e-06 29.1 20.5 1.1e-06 29.1 20.5 4.9 4 1 1 5 5 5 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 CDF35759.1 - 0.0013 19.6 0.2 0.0073 17.2 0.2 2.5 1 1 0 1 1 1 1 HHH domain Aldo_ket_red PF00248.21 CDF35760.1 - 1.4e-64 218.1 0.0 1.6e-64 217.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 CDF35761.1 - 5.9e-13 48.8 0.0 1.9e-12 47.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35761.1 - 6e-09 35.6 0.0 9.7e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 CDF35761.1 - 7e-08 32.1 3.1 0.15 12.4 0.0 5.0 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 CDF35761.1 - 0.00069 20.0 1.7 0.92 9.9 0.2 3.2 3 1 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 CDF35761.1 - 0.00081 19.5 0.0 0.0019 18.3 0.0 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CDF35761.1 - 0.068 13.7 2.9 7.9 7.1 0.1 4.1 3 1 1 4 4 4 0 HEAT-like repeat UBX PF00789.20 CDF35762.1 - 3.2e-13 49.7 0.0 5.6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 CDF35762.1 - 3.1e-10 39.7 0.1 6.2e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain Sulfotransfer_2 PF03567.14 CDF35764.1 - 6.5e-26 91.8 0.0 8.2e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family SIR2 PF02146.17 CDF35765.1 - 3.7e-25 88.9 0.0 5.5e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 Sir2 family XPA_N PF01286.18 CDF35765.1 - 0.11 12.6 0.7 1.6 8.8 0.1 2.2 2 0 0 2 2 2 0 XPA protein N-terminal zf-ribbon_3 PF13248.6 CDF35765.1 - 0.17 11.4 0.2 17 5.0 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain IRF-2BP1_2 PF11261.8 CDF35765.1 - 1.2 8.8 3.3 6 6.5 0.4 2.4 2 0 0 2 2 2 0 Interferon regulatory factor 2-binding protein zinc finger Cnd3 PF12719.7 CDF35766.1 - 3.2e-50 171.0 0.4 3.2e-50 171.0 0.4 1.8 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Anillin_N PF16018.5 CDF35766.1 - 0.034 14.7 0.4 0.11 13.1 0.4 1.9 1 0 0 1 1 1 0 Anillin N-terminus RPN7 PF10602.9 CDF35767.1 - 2e-50 170.9 0.3 3.5e-50 170.1 0.3 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CDF35767.1 - 5.2e-09 36.6 0.0 1.6e-08 35.0 0.0 1.8 2 0 0 2 2 2 1 PCI domain TFIIS_C PF01096.18 CDF35768.1 - 2.9e-08 33.4 0.1 2.9e-08 33.4 0.1 3.4 4 0 0 4 4 4 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CDF35768.1 - 0.0001 22.1 7.1 0.0001 22.1 7.1 3.3 3 1 0 3 3 3 1 RNA polymerases M/15 Kd subunit PhnA_Zn_Ribbon PF08274.12 CDF35768.1 - 0.0025 17.7 2.7 0.0031 17.4 0.1 2.4 2 1 0 2 2 2 1 PhnA Zinc-Ribbon Rpr2 PF04032.16 CDF35768.1 - 0.022 15.0 5.3 0.07 13.4 1.5 2.6 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain RecR PF02132.15 CDF35768.1 - 1.1 8.9 0.1 1.1 8.9 0.1 2.8 4 0 0 4 4 4 0 RecR protein zinc_ribbon_15 PF17032.5 CDF35768.1 - 3.1 8.6 8.2 0.58 10.9 1.5 2.4 1 1 2 3 3 3 0 zinc-ribbon family DZR PF12773.7 CDF35768.1 - 5.1 7.2 9.6 15 5.7 5.9 2.9 1 1 1 2 2 2 0 Double zinc ribbon AMPK1_CBM PF16561.5 CDF35770.1 - 3e-20 72.2 1.2 4.5e-20 71.7 0.1 1.8 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase Glyco_trans_2_3 PF13632.6 CDF35770.1 - 1.8e-19 70.4 3.2 1.8e-19 70.4 3.2 3.4 3 1 1 4 4 4 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 CDF35770.1 - 4.3e-19 68.5 17.2 5e-09 35.2 0.4 5.6 2 1 1 3 3 3 2 Cellulose synthase Glyco_tranf_2_3 PF13641.6 CDF35770.1 - 3.6e-15 56.5 0.5 3.9e-12 46.5 0.2 3.1 2 1 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDF35770.1 - 2e-13 50.5 0.8 2e-08 34.2 0.4 3.0 2 1 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CDF35770.1 - 6.9e-07 28.9 0.5 0.00024 20.6 0.1 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 CBM53 PF16760.5 CDF35770.1 - 0.046 14.3 0.0 0.14 12.8 0.0 1.7 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) DUF998 PF06197.13 CDF35770.1 - 7.7 6.1 9.6 1.8 8.2 2.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF998) Orn_Arg_deC_N PF02784.16 CDF35774.1 - 4.1e-37 127.9 0.0 5.8e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDF35774.1 - 1.2e-16 60.7 0.0 1.3e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain WD40 PF00400.32 CDF35777.1 - 2.9e-18 65.9 6.6 1.1e-05 26.1 0.1 6.4 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF35777.1 - 3.4e-07 30.5 0.0 0.85 10.0 0.0 4.5 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CDF35777.1 - 0.02 13.4 0.0 2 6.8 0.0 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 CDF35777.1 - 0.16 10.9 0.4 8 5.3 0.0 3.1 2 2 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_S8 PF00082.22 CDF35782.1 - 1.2e-41 142.9 0.2 1.9e-41 142.3 0.2 1.3 1 0 0 1 1 1 1 Subtilase family ABC_membrane PF00664.23 CDF35784.1 - 4e-62 210.3 29.4 6.2e-33 114.6 8.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDF35784.1 - 6.6e-46 156.2 0.0 5.9e-19 69.0 0.0 3.6 2 1 1 3 3 3 3 ABC transporter DUF87 PF01935.17 CDF35784.1 - 3.5e-07 30.6 0.9 0.0041 17.2 0.0 2.3 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_22 PF13401.6 CDF35784.1 - 4.2e-07 30.3 0.2 0.0044 17.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CDF35784.1 - 5.5e-07 29.7 0.0 0.015 15.4 0.0 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CDF35784.1 - 1.3e-06 29.1 0.3 0.0083 16.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CDF35784.1 - 3.3e-05 23.8 4.1 0.18 11.6 0.1 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF35784.1 - 3.5e-05 23.4 2.3 1.5 8.2 0.1 3.9 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF35784.1 - 5e-05 23.0 1.7 0.014 15.1 0.3 3.0 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CDF35784.1 - 0.0001 22.1 0.0 0.28 10.9 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDF35784.1 - 0.00013 22.4 0.2 0.45 10.9 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDF35784.1 - 0.00053 19.9 0.0 0.16 11.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 CDF35784.1 - 0.00071 19.0 1.1 1.7 8.0 0.0 3.0 3 0 0 3 3 3 2 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 CDF35784.1 - 0.0036 16.3 0.2 0.41 9.5 0.0 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.6 CDF35784.1 - 0.0043 17.2 0.1 0.029 14.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CDF35784.1 - 0.0077 15.8 0.1 1.8 8.1 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CDF35784.1 - 0.017 14.7 0.1 0.13 11.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 CDF35784.1 - 0.022 13.8 0.0 0.09 11.8 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.6 CDF35784.1 - 0.026 14.2 0.0 8.6 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 CDF35784.1 - 0.072 12.0 0.2 0.83 8.5 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain IstB_IS21 PF01695.17 CDF35784.1 - 0.081 12.7 0.0 1.1 9.0 0.0 2.6 3 0 0 3 3 2 0 IstB-like ATP binding protein DUF815 PF05673.13 CDF35784.1 - 0.11 11.7 0.0 0.44 9.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 CDF35784.1 - 0.11 11.6 0.0 1.2 8.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.23 CDF35784.1 - 0.11 12.5 1.3 1.5 8.8 0.3 2.5 2 0 0 2 2 2 0 Dynamin family NACHT PF05729.12 CDF35784.1 - 0.13 12.1 0.8 0.54 10.2 0.2 2.2 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 CDF35784.1 - 0.22 11.1 0.7 2.9 7.4 0.3 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain LRR_4 PF12799.7 CDF35785.1 - 5.7e-11 42.5 11.6 4.5e-05 23.7 0.5 4.4 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDF35785.1 - 5.3e-10 38.9 8.1 4.4e-06 26.4 2.5 2.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 CDF35785.1 - 3.2e-05 23.5 0.6 0.00052 19.6 0.3 2.4 2 1 1 3 3 3 2 Leucine-rich repeat ABC_tran PF00005.27 CDF35786.1 - 1.4e-34 119.6 0.0 5.1e-34 117.7 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CDF35786.1 - 4.2e-30 105.3 6.2 5.7e-30 104.9 6.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDF35786.1 - 5.5e-06 26.0 0.1 0.0019 17.7 0.1 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDF35786.1 - 0.00052 19.9 0.2 0.0028 17.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDF35786.1 - 0.0023 17.9 0.0 0.0058 16.6 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDF35786.1 - 0.004 16.9 0.0 0.014 15.1 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF35786.1 - 0.0043 17.5 0.0 0.012 16.0 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDF35786.1 - 0.0056 17.0 0.0 0.18 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CDF35786.1 - 0.0092 16.5 0.1 0.027 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 CDF35786.1 - 0.029 14.3 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_15 PF13175.6 CDF35786.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDF35786.1 - 0.16 12.1 0.0 0.38 10.9 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Adeno_IVa2 PF02456.15 CDF35786.1 - 0.16 10.7 0.1 6.1 5.5 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein Oxidored_q2 PF00420.24 CDF35787.1 - 2.8 7.6 10.8 1.1 8.9 0.1 2.6 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L HMGL-like PF00682.19 CDF35789.1 - 8.5e-54 182.9 0.2 9.8e-54 182.7 0.2 1.0 1 0 0 1 1 1 1 HMGL-like AFOR_C PF01314.18 CDF35789.1 - 0.058 12.4 0.0 0.12 11.3 0.0 1.4 2 0 0 2 2 2 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 zf-met PF12874.7 CDF35790.1 - 0.024 15.0 0.7 0.068 13.6 0.7 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDF35790.1 - 0.029 14.7 2.1 0.039 14.2 0.7 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CDF35790.1 - 0.034 15.0 3.8 0.24 12.3 3.8 2.6 1 0 0 1 1 1 0 C2H2-type zinc finger ARS2 PF04959.13 CDF35790.1 - 0.047 14.1 1.5 0.069 13.5 1.5 1.4 1 1 0 1 1 1 0 Arsenite-resistance protein 2 zf-BED PF02892.15 CDF35790.1 - 0.67 10.0 7.2 19 5.4 4.0 3.3 3 1 0 3 3 3 0 BED zinc finger RT_RNaseH PF17917.1 CDF35792.1 - 2.9e-33 114.3 0.3 3.5e-32 110.8 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF35792.1 - 2.6e-32 110.8 0.0 8.5e-32 109.2 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF35792.1 - 4e-17 62.1 0.1 1.3e-16 60.4 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CDF35792.1 - 3.8e-10 40.0 0.4 1.3e-09 38.3 0.0 2.1 3 0 0 3 3 3 1 Integrase core domain Chromo PF00385.24 CDF35792.1 - 2.8e-05 23.9 0.0 5.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 CDF35792.1 - 6.2e-05 23.1 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 CDF35792.1 - 0.0001 21.9 0.0 0.00021 20.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF35792.1 - 0.0053 16.5 0.2 0.044 13.6 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Mtf2_C PF14061.6 CDF35792.1 - 0.016 15.4 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Peptidase_M13_N PF05649.13 CDF35793.1 - 1.1e-79 268.8 0.0 1.4e-79 268.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CDF35793.1 - 9.7e-71 237.6 0.0 1.6e-70 236.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 Ras PF00071.22 CDF35794.1 - 4.2e-48 163.0 0.0 5e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF35794.1 - 3.6e-29 101.4 0.0 5.3e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF35794.1 - 1e-10 41.3 0.0 1.5e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 CDF35794.1 - 0.00088 19.6 0.2 0.014 15.7 0.2 2.2 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 CDF35794.1 - 0.0013 18.8 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF35794.1 - 0.0038 17.1 0.1 0.54 10.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 CDF35794.1 - 0.0042 16.5 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CDF35794.1 - 0.014 14.5 0.9 5.1 6.1 0.0 2.8 2 1 0 3 3 3 0 G-protein alpha subunit TsaE PF02367.17 CDF35794.1 - 0.058 13.4 0.0 0.15 12.0 0.0 1.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 CDF35794.1 - 0.061 13.0 0.2 0.12 12.0 0.1 1.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF35794.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 CDF35794.1 - 0.12 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CDF35794.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 CDF35794.1 - 0.15 12.4 0.0 0.23 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 CDF35794.1 - 0.19 11.5 0.1 10 5.8 0.1 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein E1-E2_ATPase PF00122.20 CDF35795.1 - 5.6e-52 175.9 10.5 1.3e-51 174.7 3.9 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDF35795.1 - 1.8e-46 158.2 7.4 1.8e-46 158.2 7.4 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CDF35795.1 - 1.6e-20 74.3 2.0 1.6e-20 74.3 2.0 2.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDF35795.1 - 2.3e-19 68.9 2.9 1.6e-18 66.1 0.0 3.0 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CDF35795.1 - 3.6e-18 65.4 0.0 6.8e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) HAD PF12710.7 CDF35795.1 - 1.1e-08 35.7 0.1 1.6e-07 31.9 0.0 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF35795.1 - 1.5e-07 31.5 0.7 1.1e-05 25.4 0.4 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PepSY_2 PF13670.6 CDF35795.1 - 0.17 11.9 0.6 3.3 7.8 0.0 2.9 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain BRCT PF00533.26 CDF35798.1 - 6.3e-05 23.3 0.0 0.022 15.1 0.0 2.2 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDF35798.1 - 8.2e-05 22.9 0.0 0.014 15.8 0.0 2.5 2 1 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 CDF35798.1 - 0.068 13.2 0.0 1.8 8.7 0.0 2.6 2 1 1 3 3 3 0 BRCA1 C Terminus (BRCT) domain CDC50 PF03381.15 CDF35800.1 - 1.3e-62 211.8 7.5 2.2e-62 211.1 2.4 2.5 1 1 1 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF4282 PF14110.6 CDF35800.1 - 0.031 15.0 1.2 0.41 11.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Glyco_trans_1_4 PF13692.6 CDF35802.1 - 7.2e-09 36.2 0.0 9.8e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDF35802.1 - 9.3e-09 35.1 0.0 1.2e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDF35802.1 - 8.4e-06 26.1 0.0 1.4e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 zf-C3HC4_3 PF13920.6 CDF35804.1 - 3.4e-13 49.2 8.0 4.7e-13 48.8 8.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF35804.1 - 1.6e-05 24.6 8.2 2.8e-05 23.9 8.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CDF35804.1 - 7.7e-05 22.9 8.5 0.00013 22.2 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDF35804.1 - 0.00011 21.9 9.5 0.0002 21.1 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF35804.1 - 0.0036 17.2 8.2 0.0068 16.3 8.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain RecR PF02132.15 CDF35804.1 - 0.015 14.9 5.7 0.019 14.5 3.0 2.3 2 0 0 2 2 2 0 RecR protein zf-P11 PF03854.14 CDF35804.1 - 0.097 12.3 3.7 0.15 11.7 3.7 1.4 1 0 0 1 1 1 0 P-11 zinc finger DZR PF12773.7 CDF35804.1 - 1.2 9.3 9.0 3.5 7.7 9.0 2.0 1 1 0 1 1 1 0 Double zinc ribbon MafB19-deam PF14437.6 CDF35804.1 - 9.3 6.0 9.2 5.2 6.8 0.5 3.0 1 1 1 2 2 2 0 MafB19-like deaminase An_peroxidase PF03098.15 CDF35806.1 - 9.2e-111 371.0 0.0 1e-110 370.8 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase PhoLip_ATPase_C PF16212.5 CDF35807.1 - 9e-65 218.9 13.9 1.2e-64 218.4 13.9 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CDF35807.1 - 6.2e-10 39.7 3.2 4.2e-06 27.2 0.1 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF35807.1 - 0.00039 20.2 0.1 0.0065 16.2 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF35807.1 - 0.019 15.1 0.0 0.89 9.7 0.0 2.4 2 0 0 2 2 2 0 Cation transport ATPase (P-type) HAD PF12710.7 CDF35807.1 - 0.022 15.2 0.1 1.8 8.9 0.0 2.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDF35807.1 - 0.026 14.6 0.4 0.1 12.7 0.0 2.0 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Zeta_toxin PF06414.12 CDF35807.1 - 0.1 11.9 0.1 2.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin TFIIS_C PF01096.18 CDF35808.1 - 2.7e-19 68.7 7.4 2.7e-19 68.7 7.4 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 CDF35808.1 - 0.037 13.7 1.8 0.049 13.3 0.2 1.9 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain DUF383 PF04063.14 CDF35810.1 - 1.1e-05 25.3 0.0 1.4e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF383) RNase_PH PF01138.21 CDF35811.1 - 4.2e-12 46.7 0.0 6.3e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF35811.1 - 5.8e-10 39.1 0.0 9.7e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Pyr_redox_2 PF07992.14 CDF35812.1 - 3e-38 131.7 0.0 3.7e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF35812.1 - 7.7e-13 48.8 0.1 1.9e-08 34.7 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDF35812.1 - 5e-06 26.3 0.2 0.033 13.8 0.0 4.0 3 1 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDF35812.1 - 1.6e-05 24.9 0.0 0.085 12.8 0.0 3.6 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CDF35812.1 - 0.0057 16.9 0.2 0.83 9.9 0.0 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CDF35812.1 - 0.0065 15.8 0.0 0.21 10.8 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF35812.1 - 0.0078 15.3 0.2 11 4.9 0.1 3.4 3 1 1 4 4 4 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CDF35812.1 - 0.019 14.1 0.9 8.8 5.3 0.2 3.1 2 1 1 3 3 3 0 Lycopene cyclase protein Anillin_N PF16018.5 CDF35813.1 - 6.6 7.4 7.6 2.3 8.9 0.3 3.6 3 0 0 3 3 3 0 Anillin N-terminus CHGN PF05679.16 CDF35814.1 - 1.2e-45 156.3 0.1 1.8e-45 155.7 0.1 1.2 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 CDF35814.1 - 6.3e-05 22.5 0.2 0.00013 21.5 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Mg_trans_NIPA PF05653.14 CDF35815.1 - 2.4e-52 177.9 12.8 1.5e-39 135.9 6.2 2.0 1 1 1 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CDF35815.1 - 3e-07 30.7 4.3 3e-07 30.7 4.3 2.9 2 1 0 3 3 3 1 EamA-like transporter family UPF0014 PF03649.13 CDF35816.1 - 3.9e-45 154.1 12.0 4.6e-45 153.8 12.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) Myb_DNA-binding PF00249.31 CDF35818.1 - 2.1e-11 43.8 0.1 0.00013 22.1 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF35818.1 - 1.9e-07 31.2 0.0 0.0064 16.7 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Pex26 PF07163.12 CDF35818.1 - 9.6 5.4 9.9 21 4.3 9.8 1.7 1 1 0 1 1 1 0 Pex26 protein Castor_Poll_mid PF06241.12 CDF35819.1 - 7.7e-25 86.9 0.0 2e-24 85.5 0.0 1.7 1 0 0 1 1 1 1 Castor and Pollux, part of voltage-gated ion channel TrkA_C PF02080.21 CDF35819.1 - 0.008 16.0 0.0 0.075 12.9 0.0 2.5 2 0 0 2 2 2 1 TrkA-C domain DUF2976 PF11190.8 CDF35819.1 - 0.024 14.5 0.2 0.051 13.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) RCR PF12273.8 CDF35820.1 - 0.065 13.9 0.5 0.58 10.8 0.0 2.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red WIF PF02019.18 CDF35820.1 - 0.19 11.4 0.0 14 5.4 0.0 2.3 2 0 0 2 2 2 0 WIF domain DEAD PF00270.29 CDF35822.1 - 3e-35 121.6 0.3 6e-35 120.6 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF35822.1 - 8.9e-26 90.4 0.0 2.3e-25 89.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF35822.1 - 1.1e-06 28.8 0.0 1.7e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NACHT PF05729.12 CDF35822.1 - 0.054 13.4 1.4 0.7 9.8 1.4 2.7 1 1 0 1 1 1 0 NACHT domain AAA PF00004.29 CDF35822.1 - 0.084 13.3 0.2 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ribosomal_S17e PF00833.18 CDF35824.1 - 4.7e-63 210.6 0.7 5.5e-63 210.3 0.7 1.0 1 0 0 1 1 1 1 Ribosomal S17 Metallophos_2 PF12850.7 CDF35825.1 - 1.4e-16 61.1 0.0 1.9e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CDF35825.1 - 0.0046 17.5 0.1 4.5 7.7 0.0 2.5 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase COX6B PF02297.17 CDF35826.1 - 1.4e-16 60.4 4.7 1.6e-16 60.3 4.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb YozE_SAM_like PF06855.12 CDF35826.1 - 0.062 13.5 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 YozE SAM-like fold UDPG_MGDP_dh_N PF03721.14 CDF35827.1 - 8.9e-36 123.2 0.0 1.2e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 CDF35827.1 - 2.2e-27 95.1 0.0 4.1e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CDF35827.1 - 2.2e-18 66.6 0.0 2.3e-17 63.3 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 CDF35827.1 - 2.2e-07 31.2 0.0 5.8e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CDF35827.1 - 0.00038 19.8 0.1 0.0023 17.3 0.1 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CDF35827.1 - 0.0028 18.1 0.0 0.0079 16.6 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CDF35827.1 - 0.0035 17.9 0.0 0.021 15.4 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 CDF35827.1 - 0.029 14.0 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 CDF35827.1 - 0.045 13.0 0.0 0.082 12.2 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CDF35827.1 - 0.062 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CDF35827.1 - 0.09 13.0 0.0 0.65 10.3 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain GGACT PF06094.12 CDF35828.1 - 2.5e-14 53.9 0.0 3.1e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 CDF35828.1 - 0.00019 21.7 0.0 0.00043 20.6 0.0 1.6 1 1 0 1 1 1 1 AIG2-like family E3_UbLigase_R4 PF13764.6 CDF35829.1 - 3.2e-146 488.7 0.0 7.4e-146 487.5 0.0 1.6 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase UBR4 ZZ PF00569.17 CDF35829.1 - 0.00058 19.6 8.8 0.00058 19.6 8.8 3.7 2 1 0 2 2 2 1 Zinc finger, ZZ type PTH2 PF01981.16 CDF35830.1 - 0.13 12.5 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 HhH-GPD PF00730.25 CDF35831.1 - 1.9e-18 66.9 0.0 3.9e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 CDF35831.1 - 4.8e-16 58.7 0.0 1.2e-15 57.4 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain HHH PF00633.23 CDF35831.1 - 1.1e-05 25.0 0.0 3e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif Peptidase_M16 PF00675.20 CDF35833.1 - 1.4e-43 148.4 0.0 2.6e-43 147.6 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDF35833.1 - 2.8e-31 108.9 0.0 4.5e-30 105.0 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain IFT20 PF14931.6 CDF35834.1 - 0.0049 17.0 3.0 0.0063 16.7 3.0 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 ATG16 PF08614.11 CDF35834.1 - 0.082 13.1 8.0 0.12 12.6 8.0 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Malectin PF11721.8 CDF35835.1 - 1.1e-13 51.6 0.0 1.6e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Malectin domain Malectin_like PF12819.7 CDF35835.1 - 0.021 14.0 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Malectin-like domain Lum_binding PF00677.17 CDF35836.1 - 2.4e-47 158.8 3.2 8.1e-23 80.2 1.4 2.2 2 0 0 2 2 2 2 Lumazine binding domain DUF4602 PF15375.6 CDF35837.1 - 2.7e-14 53.7 2.4 2.7e-14 53.7 2.4 2.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4602) Paramyxo_NS_C PF02725.14 CDF35837.1 - 0.025 14.7 0.3 0.045 13.9 0.3 1.4 1 0 0 1 1 1 0 Non-structural protein C Myb_DNA-binding PF00249.31 CDF35838.1 - 6e-13 48.8 0.9 1e-12 48.0 0.9 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF35838.1 - 0.0038 17.4 0.4 0.012 15.8 0.4 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF35838.1 - 0.022 14.7 0.3 0.022 14.7 0.3 2.5 2 0 0 2 2 2 0 Myb DNA-binding like SecY PF00344.20 CDF35839.1 - 3e-69 233.6 15.6 3.8e-69 233.3 15.6 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CDF35839.1 - 1.3e-15 56.9 0.3 7.8e-15 54.4 0.0 2.4 2 0 0 2 2 2 1 Plug domain of Sec61p Claudin_3 PF06653.11 CDF35839.1 - 0.0011 19.0 1.8 0.14 12.1 0.0 2.9 2 0 0 2 2 2 2 Tight junction protein, Claudin-like GPS2_interact PF15784.5 CDF35841.1 - 0.0038 17.6 2.3 0.0038 17.6 2.3 2.5 2 1 1 3 3 3 1 G-protein pathway suppressor 2-interacting domain PI3K_P85_iSH2 PF16454.5 CDF35841.1 - 0.022 14.4 8.2 0.038 13.6 0.3 2.5 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Taxilin PF09728.9 CDF35841.1 - 0.029 13.6 13.4 0.014 14.5 11.0 1.6 1 1 1 2 2 2 0 Myosin-like coiled-coil protein EzrA PF06160.12 CDF35841.1 - 0.1 10.7 6.0 0.084 11.0 0.7 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 CDF35841.1 - 0.14 12.6 4.6 5.5 7.5 0.5 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF4200 PF13863.6 CDF35841.1 - 0.17 12.3 16.9 1 9.8 4.2 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DivIVA PF05103.13 CDF35841.1 - 0.17 11.9 12.5 0.21 11.7 4.8 2.4 1 1 1 2 2 2 0 DivIVA protein TMPIT PF07851.13 CDF35841.1 - 0.28 10.4 2.3 0.59 9.3 2.3 1.6 1 1 0 1 1 1 0 TMPIT-like protein Takusan PF04822.13 CDF35841.1 - 0.41 10.6 4.6 3.1 7.8 2.1 2.7 2 0 0 2 2 2 0 Takusan CorA PF01544.18 CDF35841.1 - 0.64 9.3 7.4 0.7 9.2 6.8 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF2203 PF09969.9 CDF35841.1 - 1.9 9.2 13.0 2.1 9.1 5.9 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fez1 PF06818.15 CDF35841.1 - 3 8.3 14.6 3.9 7.9 14.6 1.3 1 0 0 1 1 1 0 Fez1 APG6_N PF17675.1 CDF35841.1 - 3.9 8.0 20.2 4.9 7.7 5.9 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region DivIC PF04977.15 CDF35841.1 - 5.4 6.9 11.5 1.2 9.0 2.0 2.9 2 1 1 3 3 3 0 Septum formation initiator DHR10 PF18595.1 CDF35841.1 - 6.2 6.9 24.9 4.7 7.3 4.4 3.2 1 1 1 3 3 3 0 Designed helical repeat protein 10 domain TPR_MLP1_2 PF07926.12 CDF35841.1 - 6.6 6.8 18.5 44 4.1 11.1 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein zf-C4H2 PF10146.9 CDF35841.1 - 7.3 6.8 9.1 16 5.7 6.9 1.9 1 1 1 2 2 2 0 Zinc finger-containing protein Ribosomal_L18 PF17135.4 CDF35842.1 - 8.2e-84 279.7 0.6 9.1e-84 279.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 CDF35842.1 - 9.5e-05 23.1 0.0 0.00016 22.3 0.0 1.6 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Uma2 PF05685.12 CDF35844.1 - 1e-16 61.0 0.3 8.1e-15 54.8 0.3 2.2 1 1 0 1 1 1 1 Putative restriction endonuclease Csm1_N PF18504.1 CDF35845.1 - 0.028 14.8 0.4 0.054 13.8 0.4 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain GPS2_interact PF15784.5 CDF35845.1 - 0.028 14.8 2.6 0.041 14.3 2.6 1.4 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain BetaGal_dom4_5 PF13364.6 CDF35848.1 - 0.13 12.8 0.1 0.15 12.7 0.1 1.0 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain zinc_ribbon_5 PF13719.6 CDF35850.1 - 0.31 10.9 2.5 34 4.3 0.0 3.5 3 0 0 3 3 3 0 zinc-ribbon domain UQ_con PF00179.26 CDF35851.1 - 2e-41 140.9 0.0 2.2e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 CDF35851.1 - 0.021 14.4 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 CDF35851.1 - 0.05 13.9 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF1168 PF06658.12 CDF35852.1 - 1.3e-20 73.6 12.9 1.8e-20 73.1 12.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1168) Tubulin PF00091.25 CDF35853.1 - 1.7e-69 234.0 0.0 2.8e-69 233.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDF35853.1 - 6.1e-35 120.1 0.0 9.7e-35 119.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDF35853.1 - 0.00066 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CDF35853.1 - 0.0044 16.3 0.0 0.0075 15.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 CDF35853.1 - 0.0046 17.3 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Pyr_redox_2 PF07992.14 CDF35855.1 - 2.9e-57 194.1 0.6 3.9e-57 193.7 0.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDF35855.1 - 2.3e-30 105.1 0.1 4.7e-30 104.1 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDF35855.1 - 1.8e-14 54.0 0.8 7.2e-12 45.7 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF35855.1 - 3.4e-10 39.6 5.6 4e-10 39.3 1.7 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDF35855.1 - 2e-06 27.2 4.4 0.0029 16.8 1.8 2.4 2 0 0 2 2 2 2 FAD binding domain 3HCDH_N PF02737.18 CDF35855.1 - 2.5e-05 24.3 0.4 0.018 15.0 0.5 2.6 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 CDF35855.1 - 0.002 17.8 2.8 0.002 17.8 2.8 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CDF35855.1 - 0.0029 17.0 2.8 0.0041 16.5 2.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDF35855.1 - 0.0036 17.5 3.2 0.049 13.9 2.5 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CDF35855.1 - 0.0054 15.9 0.1 0.013 14.6 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) UDPG_MGDP_dh_N PF03721.14 CDF35855.1 - 0.14 11.8 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.6 CDF35855.1 - 0.24 10.6 2.5 2.9 7.0 2.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FTHFS PF01268.19 CDF35856.1 - 6.2e-244 810.3 0.0 7e-244 810.1 0.0 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase RRM_1 PF00076.22 CDF35859.1 - 1.2e-10 41.1 0.0 2.6e-10 40.0 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF35859.1 - 0.00027 20.7 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 CDF35859.1 - 0.0017 18.7 0.1 0.24 11.6 0.2 2.1 1 1 1 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter Limkain-b1 PF11608.8 CDF35859.1 - 0.021 14.9 0.0 0.038 14.0 0.0 1.5 1 1 0 1 1 1 0 Limkain b1 RRM_3 PF08777.11 CDF35859.1 - 0.11 12.5 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif Aminotran_3 PF00202.21 CDF35860.1 - 2.5e-105 352.5 0.0 3e-105 352.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 CDF35860.1 - 0.0033 16.7 0.0 0.011 15.0 0.0 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase PolyA_pol PF01743.20 CDF35861.1 - 1.1e-24 87.2 0.3 1.8e-24 86.6 0.3 1.3 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CDF35861.1 - 2.5e-05 24.0 0.0 6.5e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A Rib_5-P_isom_A PF06026.14 CDF35864.1 - 1.9e-61 206.6 0.1 2.3e-61 206.4 0.1 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CDF35864.1 - 0.018 15.0 0.2 1.3 9.0 0.0 2.2 1 1 1 2 2 2 0 DeoR C terminal sensor domain NDUFB11 PF17250.2 CDF35865.1 - 7.5e-08 32.9 0.1 1e-07 32.5 0.1 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase 11 kDa subunit SAE2 PF08573.10 CDF35865.1 - 0.0022 19.1 0.3 0.0033 18.5 0.3 1.2 1 0 0 1 1 1 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Utp14 PF04615.13 CDF35866.1 - 1e-122 411.2 61.1 1.3e-122 410.9 61.1 1.1 1 0 0 1 1 1 1 Utp14 protein WD40 PF00400.32 CDF35867.1 - 1.2e-10 41.7 11.9 0.0093 16.8 0.8 4.9 4 0 0 4 4 4 4 WD domain, G-beta repeat PQQ_3 PF13570.6 CDF35867.1 - 0.00012 22.4 0.5 0.26 11.8 0.0 3.8 3 0 0 3 3 3 2 PQQ-like domain zf-CCHC PF00098.23 CDF35867.1 - 0.013 15.5 0.9 0.013 15.5 0.9 2.9 3 0 0 3 3 3 0 Zinc knuckle PBP1_TM PF14812.6 CDF35867.1 - 0.11 12.9 7.4 0.21 12.0 7.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-CCHC_4 PF14392.6 CDF35867.1 - 5.7 6.8 13.4 1.1 9.0 1.2 2.5 1 1 1 2 2 2 0 Zinc knuckle AAA PF00004.29 CDF35868.1 - 9.4e-41 139.3 0.0 2.3e-40 138.1 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF35868.1 - 1.2e-10 41.0 0.0 3.1e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDF35868.1 - 1.8e-05 24.7 0.1 9.3e-05 22.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDF35868.1 - 2.4e-05 24.8 0.2 0.0009 19.7 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDF35868.1 - 4.2e-05 23.9 0.0 0.0067 16.7 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 CDF35868.1 - 0.00013 22.2 0.0 0.0003 20.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDF35868.1 - 0.00079 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CDF35868.1 - 0.0012 19.4 0.0 0.0033 18.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDF35868.1 - 0.0027 16.9 0.0 0.0046 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 CDF35868.1 - 0.0034 17.6 0.0 0.006 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDF35868.1 - 0.0035 17.6 0.0 0.0059 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CDF35868.1 - 0.012 15.5 0.0 0.58 10.0 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDF35868.1 - 0.013 15.2 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDF35868.1 - 0.015 14.7 0.1 0.03 13.7 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CDF35868.1 - 0.016 15.6 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 CDF35868.1 - 0.019 14.2 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 CDF35868.1 - 0.023 14.4 0.0 0.08 12.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CDF35868.1 - 0.037 13.4 0.0 0.35 10.2 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_3 PF07726.11 CDF35868.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDF35868.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CDF35868.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CDF35868.1 - 0.095 12.4 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 CDF35868.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 CDF35868.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Tab2_like PF06485.11 CDF35870.1 - 4.4e-78 262.5 0.0 5.4e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 RNA-binding protein Tab2/Atab2 DUF4203 PF13886.6 CDF35871.1 - 6e-18 65.2 22.0 8.4e-18 64.8 22.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF5326 PF17260.2 CDF35871.1 - 0.2 11.8 0.1 0.2 11.8 0.1 3.7 3 1 1 4 4 4 0 Family of unknown function (DUF5326) DUF2070 PF09843.9 CDF35871.1 - 7.1 4.8 14.0 8.3 4.6 14.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Fcf2 PF08698.11 CDF35873.1 - 1.6e-29 102.1 0.1 3e-29 101.3 0.1 1.5 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing Lyase_1 PF00206.20 CDF35875.1 - 1e-76 258.4 0.0 1.3e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CDF35875.1 - 3.8e-16 59.6 0.0 7.8e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Pkinase PF00069.25 CDF35877.1 - 5.6e-07 29.2 0.0 1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35877.1 - 1.3e-06 27.9 0.0 2.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase G10 PF01125.17 CDF35878.1 - 1.6e-41 141.5 0.1 2.2e-41 141.1 0.1 1.1 1 0 0 1 1 1 1 G10 protein RNaseH_C PF09293.10 CDF35878.1 - 0.045 14.1 0.0 0.069 13.5 0.0 1.3 1 0 0 1 1 1 0 T4 RNase H, C terminal USP8_dimer PF08969.11 CDF35879.1 - 7.1e-08 32.6 0.0 1.6e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 USP8 dimerisation domain 60KD_IMP PF02096.20 CDF35881.1 - 2.3e-40 138.2 0.3 2.8e-40 138.0 0.3 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Cation_efflux PF01545.21 CDF35883.1 - 2.6e-30 105.7 22.4 3.5e-30 105.2 22.4 1.2 1 0 0 1 1 1 1 Cation efflux family DUF4750 PF15938.5 CDF35883.1 - 2.8 7.7 6.6 0.91 9.2 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4750) HSP90 PF00183.18 CDF35885.1 - 2.1e-182 607.6 35.4 1e-180 602.1 35.4 2.1 1 1 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CDF35885.1 - 7.5e-12 45.7 1.4 1e-11 45.3 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDF35885.1 - 5.1e-11 42.6 0.2 1.6e-10 41.0 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase COPIIcoated_ERV PF07970.12 CDF35887.1 - 2.3e-30 106.1 0.1 3.9e-30 105.3 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter Thioredoxin PF00085.20 CDF35887.1 - 4.5e-22 78.0 0.2 8.2e-22 77.1 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin ERGIC_N PF13850.6 CDF35887.1 - 1.4e-21 76.6 0.0 4.1e-21 75.1 0.0 1.8 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin_2 PF13098.6 CDF35887.1 - 2.9e-05 24.5 0.2 6.3e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CDF35887.1 - 0.00057 19.3 0.1 0.0012 18.3 0.1 1.6 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Phosphoesterase PF04185.14 CDF35887.1 - 0.0093 15.2 0.1 0.017 14.3 0.1 1.5 2 0 0 2 2 2 1 Phosphoesterase family Thioredoxin_9 PF14595.6 CDF35887.1 - 0.011 15.5 0.1 0.023 14.4 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.6 CDF35887.1 - 0.12 12.8 0.1 1.4 9.3 0.1 2.6 2 1 1 3 3 3 0 Thioredoxin-like Arf PF00025.21 CDF35888.1 - 3.8e-59 199.1 0.0 4.2e-59 198.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CDF35888.1 - 3.3e-09 36.6 0.0 3.6e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDF35888.1 - 4.8e-09 35.9 0.0 6.1e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDF35888.1 - 7.1e-09 35.9 0.0 1.4e-08 35.0 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDF35888.1 - 1.9e-08 33.9 0.1 1.6e-05 24.3 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CDF35888.1 - 4.8e-07 29.9 0.0 6.6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF35888.1 - 0.00046 19.6 0.0 0.00052 19.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDF35888.1 - 0.0017 17.9 0.1 0.043 13.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CDF35888.1 - 0.018 14.8 0.0 0.075 12.8 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Antibiotic_NAT PF02522.14 CDF35888.1 - 0.071 12.9 0.0 0.096 12.5 0.0 1.1 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase CENP-M PF11111.8 CDF35888.1 - 0.16 11.2 0.0 0.81 8.9 0.0 1.8 2 0 0 2 2 2 0 Centromere protein M (CENP-M) TCR PF03638.15 CDF35889.1 - 1.7e-14 53.8 45.9 3.7e-10 40.0 21.2 2.2 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain eIF-5_eIF-2B PF01873.17 CDF35890.1 - 5.6e-33 113.3 0.1 8.4e-33 112.7 0.1 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Mito_carr PF00153.27 CDF35892.1 - 9.6e-48 160.1 1.5 4.8e-21 74.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Oxysterol_BP PF01237.18 CDF35893.1 - 7.9e-68 229.0 0.5 1.2e-58 198.7 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein CHGN PF05679.16 CDF35894.1 - 1.2e-50 172.8 0.1 1.7e-50 172.3 0.1 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 CDF35894.1 - 0.0091 15.6 0.1 0.019 14.6 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.6 CDF35894.1 - 0.14 11.8 0.2 0.34 10.5 0.1 1.8 2 0 0 2 2 2 0 N-terminal region of glycosyl transferase group 7 Glycos_transf_3 PF00591.21 CDF35895.1 - 2.7e-89 299.1 0.8 3.5e-89 298.7 0.8 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CDF35895.1 - 1.1e-12 47.6 0.1 2.2e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Rieske PF00355.26 CDF35897.1 - 2.9e-17 62.4 0.0 5.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 CDF35897.1 - 8.8e-13 48.2 0.1 2.7e-12 46.7 0.0 1.8 2 0 0 2 2 2 1 Pheophorbide a oxygenase Amastin PF07344.11 CDF35897.1 - 0.0089 15.9 0.3 0.015 15.2 0.3 1.3 1 0 0 1 1 1 1 Amastin surface glycoprotein DNApol3-delta_C PF09115.10 CDF35900.1 - 0.094 13.2 0.4 0.95 10.0 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III, delta subunit, C terminal HCV_NS5a PF01506.19 CDF35900.1 - 0.14 12.1 0.1 0.32 10.9 0.1 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a protein membrane anchor gag_pre-integrs PF13976.6 CDF35902.1 - 2.8e-12 46.3 0.0 4.9e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CDF35902.1 - 9.8e-06 25.8 0.1 6.9e-05 23.0 0.1 2.1 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 CDF35902.1 - 0.0072 16.1 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain APH PF01636.23 CDF35904.1 - 1.8e-06 28.1 0.3 3.2e-06 27.2 0.1 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF35904.1 - 0.21 10.8 0.0 2.1 7.6 0.0 2.1 1 1 0 1 1 1 0 Ecdysteroid kinase PAAR_motif PF05488.13 CDF35905.1 - 0.025 14.8 0.3 0.033 14.4 0.3 1.2 1 0 0 1 1 1 0 PAAR motif HCV_NS1 PF01560.17 CDF35907.1 - 0.099 11.3 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 APH PF01636.23 CDF35908.1 - 5.5e-05 23.2 0.0 9e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family HTH_Tnp_Tc3_1 PF11427.8 CDF35909.1 - 4.4e-09 36.0 0.0 8.1e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF35909.1 - 2.4e-05 24.0 0.4 0.00013 21.7 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF35909.1 - 2.8e-05 23.8 0.3 0.00012 21.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 CDF35909.1 - 0.00068 20.2 3.7 0.065 13.9 1.4 2.7 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF35909.1 - 0.011 16.0 1.9 0.016 15.5 0.9 1.8 1 1 1 2 2 2 0 Transposase HTH_11 PF08279.12 CDF35909.1 - 0.041 13.8 0.1 0.26 11.3 0.0 2.3 2 1 1 3 3 3 0 HTH domain HTH_29 PF13551.6 CDF35909.1 - 0.047 13.7 0.5 0.15 12.1 0.4 2.0 1 1 0 1 1 1 0 Winged helix-turn helix Fea1 PF07692.11 CDF35912.1 - 3.9e-20 72.2 0.1 5.1e-20 71.8 0.1 1.0 1 0 0 1 1 1 1 Low iron-inducible periplasmic protein DEAD PF00270.29 CDF35914.1 - 2.4e-43 148.0 0.0 4.2e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF35914.1 - 4.4e-22 78.5 0.0 2.7e-21 76.0 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDF35914.1 - 4.5e-13 49.2 0.0 9.4e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CDF35914.1 - 3.6e-07 30.3 0.0 1.5e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TRAPPC9-Trs120 PF08626.11 CDF35915.1 - 5.6e-12 43.9 0.0 5.3e-06 24.1 0.0 3.3 1 1 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Sedlin_N PF04628.13 CDF35916.1 - 2.7e-35 121.3 0.1 3.1e-35 121.2 0.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 CDF35916.1 - 0.0012 18.7 0.0 0.0013 18.6 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Dak1 PF02733.17 CDF35917.1 - 2.9e-80 269.5 2.3 4.6e-80 268.8 2.3 1.3 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 CDF35917.1 - 1.1e-33 116.6 2.8 1.1e-33 116.6 2.8 1.8 2 0 0 2 2 2 1 DAK2 domain PITH PF06201.13 CDF35918.1 - 4.8e-41 140.5 0.0 5.7e-41 140.3 0.0 1.1 1 0 0 1 1 1 1 PITH domain NAD_kinase PF01513.21 CDF35919.1 - 2.2e-64 217.4 0.0 3.2e-64 217.0 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase ADK PF00406.22 CDF35919.1 - 6.7e-28 97.7 0.0 1.3e-27 96.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDF35919.1 - 3.4e-16 59.9 0.0 1.3e-15 58.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDF35919.1 - 1e-06 29.3 0.0 2.6e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDF35919.1 - 4.7e-06 26.8 0.0 1.2e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CDF35919.1 - 0.00013 21.7 0.0 0.0005 19.9 0.0 1.9 2 0 0 2 2 2 1 Cytidylate kinase AAA_22 PF13401.6 CDF35919.1 - 0.0047 17.2 0.0 0.014 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CDF35919.1 - 0.015 15.7 0.0 0.028 14.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF35919.1 - 0.024 15.0 0.1 0.069 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 CDF35919.1 - 0.033 14.4 0.1 0.066 13.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDF35919.1 - 0.076 12.8 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 CDF35919.1 - 0.086 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 CDF35919.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CDF35919.1 - 0.16 11.7 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DAGK_cat PF00781.24 CDF35919.1 - 0.17 11.5 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain AAA_5 PF07728.14 CDF35919.1 - 0.19 11.7 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SR-25 PF10500.9 CDF35919.1 - 8.9 5.8 11.0 18 4.9 11.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GST_C_3 PF14497.6 CDF35920.1 - 4.5e-15 55.6 0.0 5.9e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDF35920.1 - 2.2e-08 34.3 0.0 3.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDF35920.1 - 0.00012 22.2 0.0 0.00022 21.4 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDF35920.1 - 0.0036 17.3 0.0 0.0088 16.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CDF35920.1 - 0.021 15.4 0.0 0.038 14.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CDF35920.1 - 0.03 14.6 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDF35921.1 - 2.6e-15 56.4 0.0 4e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDF35921.1 - 3.7e-10 40.0 0.0 7.3e-10 39.1 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDF35921.1 - 0.00036 20.7 0.0 0.00063 19.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CDF35921.1 - 0.00066 20.2 0.0 0.00095 19.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDF35921.1 - 0.0027 18.1 0.0 0.0045 17.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDF35921.1 - 0.022 14.8 0.0 0.057 13.4 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pkinase PF00069.25 CDF35922.1 - 8.5e-34 117.1 0.0 1.2e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF35922.1 - 5.5e-22 78.3 0.0 7.1e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2477 PF10631.9 CDF35922.1 - 0.03 15.0 2.3 0.031 15.0 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) MAGUK_N_PEST PF10608.9 CDF35922.1 - 0.39 11.2 1.9 14 6.1 1.4 2.7 2 1 0 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK UCR_14kD PF02271.16 CDF35923.1 - 0.083 12.9 4.5 0.29 11.1 4.5 1.9 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Med18 PF09637.10 CDF35923.1 - 0.45 10.3 3.1 0.21 11.4 0.7 1.6 2 0 0 2 2 2 0 Med18 protein DUF932 PF06067.11 CDF35923.1 - 1.5 8.5 8.4 2.4 7.9 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF932) Ribosomal_L35Ae PF01247.18 CDF35925.1 - 1.4e-12 47.6 0.2 1.6e-12 47.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae Ribosomal_L35Ae PF01247.18 CDF35926.1 - 0.00051 20.2 0.0 0.00059 19.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae DDE_3 PF13358.6 CDF35927.1 - 4e-08 33.2 0.0 6.1e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Raffinose_syn PF05691.12 CDF35930.1 - 2.4e-60 204.2 0.0 1.2e-57 195.3 0.0 2.9 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 FKBP_C PF00254.28 CDF35931.1 - 2.5e-05 24.5 0.0 4.9e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PsbQ PF05757.11 CDF35931.1 - 0.19 11.4 0.3 0.3 10.8 0.3 1.2 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) tRNA-synt_1 PF00133.22 CDF35932.1 - 5.8e-40 137.1 0.2 3.2e-12 45.5 0.0 4.0 4 0 0 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDF35932.1 - 1.4e-19 70.1 0.3 2.8e-10 39.5 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CDF35932.1 - 7.2e-13 48.8 0.0 1.6e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CDF35932.1 - 8.6e-09 35.2 0.0 1.5e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDF35932.1 - 0.044 12.7 0.0 0.084 11.8 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (K) PPR_2 PF13041.6 CDF35933.1 - 5.5e-86 282.6 0.1 5.9e-12 45.6 0.1 15.0 12 3 3 15 15 15 11 PPR repeat family PPR_3 PF13812.6 CDF35933.1 - 1.4e-59 198.0 0.0 4.8e-08 33.0 0.0 12.3 10 4 2 13 13 13 9 Pentatricopeptide repeat domain PPR PF01535.20 CDF35933.1 - 1.2e-51 169.4 17.3 4.1e-06 26.7 0.0 17.4 17 2 0 17 17 17 8 PPR repeat PPR_1 PF12854.7 CDF35933.1 - 6.8e-47 156.9 29.8 2.9e-06 26.9 0.0 16.6 18 1 0 18 18 18 9 PPR repeat PPR_long PF17177.4 CDF35933.1 - 4.9e-23 81.6 6.9 1.9e-09 37.2 0.1 6.8 4 2 2 7 7 7 4 Pentacotripeptide-repeat region of PRORP TPR_7 PF13176.6 CDF35933.1 - 6.2e-07 29.0 8.1 0.32 11.1 0.0 6.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF35933.1 - 4e-05 24.1 17.7 4.9 8.2 0.0 9.5 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF35933.1 - 4.8e-05 23.8 10.6 36 5.0 0.0 7.6 7 1 1 8 8 8 0 Tetratricopeptide repeat DUF4937 PF16291.5 CDF35933.1 - 0.00042 20.5 0.4 0.001 19.3 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4937 TPR_4 PF07721.14 CDF35933.1 - 0.00044 20.6 0.2 44 5.1 0.0 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF35933.1 - 0.0041 17.1 1.4 4 7.8 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat BKACE PF05853.12 CDF35933.1 - 0.0081 15.5 0.0 2.6 7.3 0.0 3.4 2 2 0 2 2 2 1 beta-keto acid cleavage enzyme TPR_8 PF13181.6 CDF35933.1 - 0.13 12.6 0.0 6 7.3 0.0 3.5 4 0 0 4 4 2 0 Tetratricopeptide repeat RRM_1 PF00076.22 CDF35934.1 - 1e-18 66.9 0.0 1.6e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF35934.1 - 0.054 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif UvrD-helicase PF00580.21 CDF35935.1 - 5.4e-69 233.1 0.1 1.8e-67 228.1 0.1 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CDF35935.1 - 8.1e-60 203.0 0.0 1.5e-59 202.1 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CDF35935.1 - 2.8e-35 121.8 0.0 5.4e-35 120.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDF35935.1 - 7.2e-08 32.1 0.0 4e-07 29.7 0.0 2.3 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CDF35935.1 - 1.9e-07 31.0 0.1 6.2e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 CDF35935.1 - 0.00021 21.2 0.0 0.0005 19.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDF35935.1 - 0.00078 19.2 0.1 1.1 8.9 0.0 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CDF35935.1 - 0.0049 16.9 0.0 0.048 13.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_12 PF13087.6 CDF35935.1 - 0.012 15.2 0.2 5.2 6.6 0.2 2.8 2 1 1 3 3 3 0 AAA domain AAA_16 PF13191.6 CDF35935.1 - 0.065 13.6 0.1 0.31 11.4 0.1 2.4 1 1 0 1 1 1 0 AAA ATPase domain Gar1 PF04410.14 CDF35936.1 - 2.2e-34 118.5 0.8 5.8e-34 117.1 0.8 1.7 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region RAP1 PF07218.11 CDF35936.1 - 4.1 5.6 10.8 5.4 5.2 10.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAP2 PF01569.21 CDF35937.1 - 1.9e-15 56.9 10.7 2.3e-15 56.5 10.1 1.4 1 1 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CDF35937.1 - 0.0029 17.3 15.9 0.017 14.9 15.1 2.4 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 CDF35937.1 - 0.022 15.3 4.4 0.022 15.3 4.4 2.2 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Proteasome PF00227.26 CDF35940.1 - 1.5e-55 187.7 0.4 1.8e-55 187.4 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF35940.1 - 1.6e-14 53.3 0.2 2.9e-14 52.4 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Slu7 PF11708.8 CDF35941.1 - 3.1e-79 266.5 12.1 3.1e-79 266.5 12.1 2.2 2 0 0 2 2 2 2 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CDF35941.1 - 0.044 13.5 0.5 0.096 12.4 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle 2-oxoacid_dh PF00198.23 CDF35942.1 - 2.5e-69 233.3 0.0 3.9e-69 232.7 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDF35942.1 - 1.9e-14 53.2 0.4 4.3e-14 52.1 0.4 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CDF35942.1 - 0.047 14.0 0.0 0.19 12.1 0.0 2.1 1 0 0 1 1 1 0 e3 binding domain Macoilin PF09726.9 CDF35942.1 - 3.2 6.2 9.8 4.2 5.8 9.8 1.2 1 0 0 1 1 1 0 Macoilin family Sigma70_r2 PF04542.14 CDF35943.1 - 2.6e-21 75.1 0.0 6.8e-21 73.8 0.0 1.8 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CDF35943.1 - 8.4e-21 73.2 2.5 4.4e-19 67.8 0.3 2.9 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r3 PF04539.16 CDF35943.1 - 3.9e-18 65.3 0.5 1.6e-15 56.9 0.1 2.7 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r1_2 PF00140.20 CDF35943.1 - 4e-09 36.3 1.3 4e-09 36.3 1.3 1.9 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 Sigma70_r4_2 PF08281.12 CDF35943.1 - 0.0022 17.7 2.4 0.028 14.1 0.1 3.3 3 1 0 3 3 3 1 Sigma-70, region 4 TFIIF_alpha PF05793.12 CDF35943.1 - 0.055 12.1 1.3 0.083 11.5 1.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ELL PF10390.9 CDF35945.1 - 2.1e-14 53.7 0.2 2.1e-14 53.7 0.2 1.9 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 CDF35945.1 - 2.2e-08 34.7 1.5 2.2e-08 34.7 1.5 2.1 2 1 1 3 3 3 1 Occludin homology domain CorA PF01544.18 CDF35946.1 - 2.7e-07 30.2 4.6 2.7e-07 30.2 4.6 2.1 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein Stevor PF17410.2 CDF35946.1 - 0.11 12.0 0.8 0.2 11.2 0.8 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF4381 PF14316.6 CDF35946.1 - 0.13 12.6 0.1 0.29 11.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Fig1 PF12351.8 CDF35946.1 - 0.14 12.1 2.7 0.23 11.4 2.7 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Cyclin_C_2 PF16899.5 CDF35946.1 - 0.14 12.5 0.3 0.92 9.9 0.3 2.4 1 1 0 1 1 1 0 Cyclin C-terminal domain NDK PF00334.19 CDF35947.1 - 3.7e-46 156.5 0.0 4.2e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase HTH_Tnp_IS1 PF12759.7 CDF35947.1 - 0.21 11.3 0.6 1.2 8.8 0.2 2.2 2 0 0 2 2 2 0 InsA C-terminal domain YdfZ PF14001.6 CDF35948.1 - 0.07 13.6 0.0 0.27 11.7 0.0 2.1 2 0 0 2 2 2 0 YdfZ protein Pescadillo_N PF06732.11 CDF35949.1 - 4.1e-101 338.1 0.5 4.1e-101 338.1 0.5 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 CDF35949.1 - 0.02 15.3 0.0 0.052 14.0 0.0 1.7 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain CENP-B_dimeris PF09026.10 CDF35949.1 - 1.5 9.3 21.1 0.094 13.1 7.2 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Myc_N PF01056.18 CDF35949.1 - 9.7 6.0 27.1 7.2 6.4 18.7 2.4 2 0 0 2 2 2 0 Myc amino-terminal region ERO1 PF04137.15 CDF35952.1 - 6.6e-106 354.5 0.1 7.9e-106 354.2 0.1 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DASH_Dad2 PF08654.10 CDF35952.1 - 0.077 13.4 0.0 1.3 9.5 0.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 Herpes_U55 PF06501.11 CDF35952.1 - 0.1 11.4 0.2 0.18 10.6 0.2 1.3 1 0 0 1 1 1 0 Human herpesvirus U55 protein MFS_1 PF07690.16 CDF35954.1 - 1e-20 74.0 17.6 1e-20 74.0 17.6 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CDF35954.1 - 2.3e-15 56.1 16.2 8.7e-15 54.2 5.0 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein PUCC PF03209.15 CDF35954.1 - 2.1e-10 40.2 2.8 2.1e-10 40.2 2.8 2.2 2 1 0 2 2 2 1 PUCC protein BT1 PF03092.16 CDF35954.1 - 4.3e-05 21.9 1.6 8.4e-05 21.0 1.6 1.5 1 0 0 1 1 1 1 BT1 family DUF4231 PF14015.6 CDF35954.1 - 2.4 8.7 0.0 2.4 8.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Clathrin PF00637.20 CDF35955.1 - 1.9e-09 37.5 0.0 4.1e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Region in Clathrin and VPS CtaG_Cox11 PF04442.14 CDF35956.1 - 1.1e-61 207.3 0.1 1.5e-61 206.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Glyco_transf_41 PF13844.6 CDF35957.1 - 4.1e-134 447.5 0.0 1.3e-69 234.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_11 PF13414.6 CDF35957.1 - 1.6e-26 91.7 0.4 2.8e-05 23.7 0.0 6.7 2 1 4 6 6 6 5 TPR repeat TPR_1 PF00515.28 CDF35957.1 - 2e-26 90.7 0.1 0.00087 19.0 0.2 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDF35957.1 - 4.2e-25 85.8 0.0 0.006 16.7 0.0 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 CDF35957.1 - 1.7e-21 74.5 0.3 0.0038 17.2 0.2 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF35957.1 - 4e-17 62.6 9.9 1.4e-07 32.0 1.6 4.9 2 2 4 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDF35957.1 - 2.6e-16 58.4 0.3 0.018 15.0 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDF35957.1 - 2.3e-15 55.8 8.3 5.1e-05 23.4 0.2 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDF35957.1 - 1.7e-13 50.7 12.8 2.3e-05 24.6 0.4 5.3 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 CDF35957.1 - 7.8e-12 45.0 11.9 0.15 12.9 0.1 6.9 3 1 4 7 7 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 CDF35957.1 - 1.6e-11 44.5 6.5 0.0007 20.0 0.2 4.6 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDF35957.1 - 2.8e-09 36.6 14.8 0.012 15.5 0.5 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_5 PF12688.7 CDF35957.1 - 0.00084 19.6 1.0 0.043 14.1 0.2 2.6 1 1 2 3 3 3 2 Tetratrico peptide repeat TPR_15 PF13429.6 CDF35957.1 - 0.00095 18.5 1.6 0.02 14.1 0.8 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDF35957.1 - 0.0044 17.5 8.6 0.63 10.8 1.8 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF35957.1 - 0.018 15.6 1.2 20 6.1 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat FAT PF02259.23 CDF35957.1 - 0.071 12.3 0.0 0.45 9.7 0.0 2.5 1 1 0 1 1 1 0 FAT domain TPR_21 PF09976.9 CDF35957.1 - 0.079 12.7 0.9 3.5 7.3 0.1 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 CDF35957.1 - 0.48 10.6 14.4 17 5.7 0.1 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat BTAD PF03704.17 CDF35957.1 - 0.63 10.5 7.3 6.6 7.2 0.3 2.9 1 1 3 4 4 4 0 Bacterial transcriptional activator domain CNTF PF01110.17 CDF35958.1 - 0.0064 15.9 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Ciliary neurotrophic factor Transglut_core PF01841.19 CDF35958.1 - 0.023 15.1 0.0 7.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Transglutaminase-like superfamily Sel1 PF08238.12 CDF35959.1 - 2.1e-87 285.6 16.3 6.2e-06 26.7 0.1 13.9 14 0 0 14 14 14 13 Sel1 repeat TPR_6 PF13174.6 CDF35959.1 - 5.5e-13 48.7 8.1 0.91 10.3 0.1 10.0 11 1 1 12 12 12 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF35959.1 - 8.2e-10 38.4 0.0 25 5.5 0.0 11.0 13 0 0 13 13 13 1 Tetratricopeptide repeat TPIP1 PF15338.6 CDF35959.1 - 0.035 14.2 0.2 55 3.8 0.0 4.8 6 0 0 6 6 6 0 p53-regulated apoptosis-inducing protein 1 TPR_19 PF14559.6 CDF35959.1 - 1 9.9 5.3 71 4.0 0.1 5.7 7 0 0 7 7 7 0 Tetratricopeptide repeat Sel1 PF08238.12 CDF35963.1 - 1.1e-13 51.4 9.8 8.9e-05 23.0 0.1 6.9 7 0 0 7 7 7 4 Sel1 repeat TPR_16 PF13432.6 CDF35963.1 - 0.35 11.5 11.1 23 5.7 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Hist_deacetyl PF00850.19 CDF35964.1 - 6e-74 249.3 0.0 9e-74 248.7 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Plant_tran PF04827.14 CDF35965.1 - 2.4e-80 269.0 0.0 2.7e-80 268.8 0.0 1.0 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF35965.1 - 7.5e-13 48.4 0.0 9.4e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HSP90 PF00183.18 CDF35966.1 - 7e-73 246.3 6.2 8.5e-73 246.0 6.2 1.2 1 0 0 1 1 1 1 Hsp90 protein Phosphonate-bd PF12974.7 CDF35966.1 - 0.038 13.6 0.0 4 6.9 0.0 2.3 1 1 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein ESM4 PF15952.5 CDF35966.1 - 0.14 12.6 0.3 0.14 12.6 0.3 1.7 2 0 0 2 2 2 0 Enhancer of split M4 family FKBP_C PF00254.28 CDF35968.1 - 4e-16 59.1 0.0 9e-16 58.0 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NusG PF02357.19 CDF35969.1 - 8.5e-12 45.4 0.1 2.2e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 Transcription termination factor nusG KOW PF00467.29 CDF35969.1 - 0.00037 20.3 0.0 0.00084 19.2 0.0 1.6 1 0 0 1 1 1 1 KOW motif TFIIS_M PF07500.14 CDF35970.1 - 2.4e-27 95.6 2.8 5.2e-27 94.6 2.8 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CDF35970.1 - 1.7e-18 66.2 7.7 3e-18 65.4 7.7 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Antig_Caf1 PF09255.10 CDF35970.1 - 0.096 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Caf1 Capsule antigen Baculo_LEF5_C PF11792.8 CDF35970.1 - 0.35 10.6 1.9 0.53 10.0 0.0 2.2 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain tRNA_Me_trans PF03054.16 CDF35971.1 - 1.3e-111 372.9 0.0 1.6e-111 372.5 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase SufE PF02657.15 CDF35971.1 - 1.7e-21 76.3 0.0 2.9e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Fe-S metabolism associated domain Asn_synthase PF00733.21 CDF35971.1 - 0.00097 18.9 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 CDF35971.1 - 0.077 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) DUF4911 PF16256.5 CDF35971.1 - 0.13 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) NAD_synthase PF02540.17 CDF35971.1 - 0.4 9.8 3.7 14 4.7 0.4 2.9 3 1 0 3 3 3 0 NAD synthase RNase_PH PF01138.21 CDF35972.1 - 5.1e-12 46.4 0.0 8.5e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF35972.1 - 2.8e-09 36.9 0.0 4.5e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SBP_bac_3 PF00497.20 CDF35973.1 - 0.0096 15.4 0.0 0.033 13.6 0.0 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan PF00060.26 CDF35973.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Ligand-gated ion channel Dus PF01207.17 CDF35975.1 - 2.3e-61 207.6 0.0 3.1e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) NFACT-R_2 PF18297.1 CDF35975.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 NFACT protein RNA binding domain His_biosynth PF00977.21 CDF35975.1 - 0.093 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein SANTA PF09133.10 CDF35976.1 - 4.9e-13 49.4 0.2 1e-12 48.3 0.2 1.6 1 0 0 1 1 1 1 SANTA (SANT Associated) SRP-alpha_N PF04086.13 CDF35976.1 - 2.8 7.8 15.0 0.32 10.9 10.3 1.7 1 1 1 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 CDF35977.1 - 6.5e-112 374.2 0.6 1.7e-110 369.5 0.6 2.0 1 1 0 1 1 1 1 Presenilin DUF4181 PF13789.6 CDF35977.1 - 0.014 15.6 3.7 0.014 15.6 3.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) Cytomega_TRL10 PF06084.11 CDF35977.1 - 0.1 12.6 0.1 0.57 10.2 0.1 2.3 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein Wzy_C PF04932.15 CDF35977.1 - 0.43 10.2 13.1 4 7.0 0.0 3.3 3 0 0 3 3 3 0 O-Antigen ligase Stevor PF17410.2 CDF35977.1 - 4 6.9 6.2 2.5 7.6 3.9 1.8 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame Macoilin PF09726.9 CDF35977.1 - 4.2 5.8 7.9 5.8 5.3 7.9 1.2 1 0 0 1 1 1 0 Macoilin family PIP49_N PF14875.6 CDF35977.1 - 6.5 6.6 6.4 3.8 7.3 4.3 1.7 1 1 0 1 1 1 0 N-term cysteine-rich ER, FAM69 ClpS PF02617.17 CDF35979.1 - 1.7e-08 34.1 0.7 2.8e-08 33.4 0.7 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS MFAP1 PF06991.11 CDF35981.1 - 3.9e-32 111.9 13.5 5.4e-32 111.4 13.5 1.2 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing RhgB_N PF09284.10 CDF35981.1 - 0.091 12.3 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Rhamnogalacturonan lyase B, N-terminal ADK PF00406.22 CDF35982.1 - 3.3e-47 160.4 0.0 4.8e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase NDK PF00334.19 CDF35982.1 - 3.2e-39 134.1 0.0 5.1e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase AAA_17 PF13207.6 CDF35982.1 - 1.6e-35 122.5 0.0 2.7e-35 121.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Dpy-30 PF05186.13 CDF35982.1 - 5.7e-10 38.7 0.1 9.1e-10 38.1 0.1 1.3 1 0 0 1 1 1 1 Dpy-30 motif AAA_18 PF13238.6 CDF35982.1 - 2.9e-07 31.1 0.0 5.7e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CDF35982.1 - 3.9e-05 23.4 0.3 0.04 13.6 0.1 2.3 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 CDF35982.1 - 0.00075 19.7 0.1 0.64 10.2 0.0 2.6 3 0 0 3 3 3 2 AAA domain Ploopntkinase3 PF18751.1 CDF35982.1 - 0.053 13.4 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Biotin_lipoyl PF00364.22 CDF35983.1 - 3.3e-10 39.7 0.1 1.2e-09 37.9 0.1 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 CDF35983.1 - 0.0063 16.4 0.0 0.027 14.4 0.0 2.0 1 1 0 1 1 1 1 RnfC Barrel sandwich hybrid domain DUF2358 PF10184.9 CDF35984.1 - 0.00016 22.0 0.0 0.00021 21.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) AmpE PF17113.5 CDF35984.1 - 0.0002 20.8 0.1 0.00026 20.4 0.1 1.0 1 0 0 1 1 1 1 Regulatory signalling modulator protein AmpE MA3 PF02847.17 CDF35985.1 - 3e-12 46.5 0.3 1.3e-11 44.5 0.0 2.2 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 CDF35985.1 - 4.2e-07 29.8 0.0 1e-06 28.5 0.0 1.6 2 0 0 2 2 2 1 MIF4G domain Actin PF00022.19 CDF35986.1 - 5.3e-135 450.1 0.0 1.8e-134 448.4 0.0 1.7 1 1 0 1 1 1 1 Actin Vps26 PF03643.15 CDF35989.1 - 8.6e-109 362.8 1.0 9.9e-109 362.6 1.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 CDF35989.1 - 0.0052 17.2 0.1 0.14 12.6 0.1 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CDF35989.1 - 0.0086 16.1 1.4 0.07 13.2 0.2 2.6 2 1 1 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Metallophos PF00149.28 CDF35992.1 - 9.4e-38 130.8 0.1 1.2e-37 130.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDF35992.1 - 6.3e-18 64.9 0.2 1.2e-17 64.1 0.2 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Cation_efflux PF01545.21 CDF35993.1 - 2.6e-19 69.7 6.2 3.3e-19 69.4 6.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDF35993.1 - 9.7e-12 44.9 0.7 1.5e-11 44.3 0.7 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter 3Beta_HSD PF01073.19 CDF35995.1 - 4.7e-27 94.7 0.0 6.5e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDF35995.1 - 1.6e-15 57.3 0.0 2.2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CDF35995.1 - 1.1e-05 25.4 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CDF35995.1 - 0.00027 20.2 0.0 0.0075 15.4 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CDF35995.1 - 0.09 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family eIF-1a PF01176.19 CDF35996.1 - 1.2e-22 79.5 0.1 1.3e-22 79.3 0.1 1.0 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RsgA_N PF16745.5 CDF35996.1 - 2.6e-06 27.1 0.0 3e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 RsgA N-terminal domain RNase_II_C_S1 PF18614.1 CDF35996.1 - 0.028 14.4 0.0 0.15 12.0 0.0 1.9 1 1 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain RTP1_C2 PF10304.9 CDF35996.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 2 Ribosomal_L32p PF01783.23 CDF35997.1 - 1.2 9.4 0.0 1.2 9.4 0.0 3.0 2 1 1 3 3 3 0 Ribosomal L32p protein family Acetyltransf_CG PF14542.6 CDF35999.1 - 2.7e-21 75.5 0.0 3e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 CDF35999.1 - 0.00015 22.0 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF35999.1 - 0.00019 21.4 0.0 0.00022 21.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF35999.1 - 0.0012 19.2 0.0 0.0015 18.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDF35999.1 - 0.053 13.6 0.0 0.072 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CDF35999.1 - 0.088 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase HTH_38 PF13936.6 CDF36000.1 - 4.8e-11 42.2 2.9 3.4e-09 36.3 0.2 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_32 PF13565.6 CDF36000.1 - 4.2e-09 36.9 3.8 1.9e-06 28.4 0.4 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_1 PF11427.8 CDF36000.1 - 5.3e-09 35.8 0.0 9.2e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_23 PF13384.6 CDF36000.1 - 2.8e-05 23.8 1.5 0.014 15.2 0.1 2.4 2 1 0 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF36000.1 - 0.002 18.3 2.2 0.0041 17.3 1.0 1.9 2 0 0 2 2 2 1 Transposase HTH_6 PF01418.17 CDF36000.1 - 0.0042 17.0 0.2 2.3 8.2 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain, rpiR family HTH_29 PF13551.6 CDF36000.1 - 0.0042 17.1 0.5 0.13 12.3 0.0 2.4 1 1 1 2 2 2 1 Winged helix-turn helix HTH_11 PF08279.12 CDF36000.1 - 0.02 14.8 2.0 2.4 8.2 0.1 2.3 2 0 0 2 2 2 0 HTH domain LacI PF00356.21 CDF36000.1 - 0.028 14.2 0.7 3.8 7.4 0.1 2.7 1 1 0 2 2 2 0 Bacterial regulatory proteins, lacI family TrmB PF01978.19 CDF36000.1 - 0.049 13.5 0.1 0.34 10.8 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_3 PF01381.22 CDF36000.1 - 0.053 13.6 0.1 6.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix HTH_24 PF13412.6 CDF36000.1 - 0.058 13.0 0.2 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 CDF36000.1 - 0.087 12.8 0.1 0.7 9.9 0.0 2.1 2 0 0 2 2 2 0 MarR family MarR_2 PF12802.7 CDF36000.1 - 0.17 11.8 1.3 4.7 7.2 0.1 2.3 1 1 1 2 2 2 0 MarR family DDE_3 PF13358.6 CDF36001.1 - 1.6e-08 34.4 0.2 2.5e-08 33.8 0.2 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Lin0512_fam PF09585.10 CDF36002.1 - 1.3e-35 121.9 0.3 1.5e-35 121.7 0.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein (Lin0512_fam) HA1 PF18239.1 CDF36003.1 - 0.047 13.5 0.0 0.053 13.4 0.0 1.1 1 0 0 1 1 1 0 Hemagglutinin I Tic22 PF04278.12 CDF36005.1 - 5.9e-30 104.5 0.0 7.4e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Tic22-like family Pribosyltran PF00156.27 CDF36006.1 - 2e-18 66.4 0.0 2.4e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoribosyl transferase domain VWA_2 PF13519.6 CDF36010.1 - 6.4e-13 49.3 0.0 2.6e-12 47.3 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain AAA_lid_2 PF17863.1 CDF36010.1 - 1.2e-12 47.5 0.8 1.2e-12 47.5 0.8 3.1 3 0 0 3 3 2 1 AAA lid domain Mg_chelatase PF01078.21 CDF36010.1 - 2.1e-11 43.6 0.1 2.7e-10 40.0 0.1 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI MCM PF00493.23 CDF36010.1 - 1.6e-08 33.9 0.0 4.9e-08 32.4 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain VWA PF00092.28 CDF36010.1 - 8.5e-08 32.6 0.0 2.2e-07 31.3 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain AAA_5 PF07728.14 CDF36010.1 - 4.5e-06 26.7 0.0 0.00018 21.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDF36010.1 - 6.4e-06 26.0 0.0 0.00013 21.7 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain DUF444 PF04285.12 CDF36010.1 - 0.079 12.0 0.0 0.079 12.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF444) GEN1_C PF18380.1 CDF36010.1 - 0.2 12.6 4.8 0.53 11.2 4.8 1.7 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain PAXIP1_C PF15364.6 CDF36010.1 - 0.27 11.5 9.7 0.56 10.5 9.7 1.4 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein DNA_pol_phi PF04931.13 CDF36010.1 - 5.3 5.0 7.2 7.4 4.5 7.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Syntaxin-18_N PF10496.9 CDF36011.1 - 1.1e-06 28.8 0.5 5.8e-06 26.5 0.0 2.2 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus TMCO5 PF14992.6 CDF36011.1 - 0.73 9.4 7.3 1.3 8.5 7.3 1.4 1 0 0 1 1 1 0 TMCO5 family FUSC PF04632.12 CDF36011.1 - 1.1 7.8 8.6 1.9 6.9 2.2 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein family Cnn_1N PF07989.11 CDF36011.1 - 1.6 8.9 11.2 33 4.7 0.0 4.1 2 1 2 4 4 4 0 Centrosomin N-terminal motif 1 Ntox1 PF15500.6 CDF36012.1 - 0.065 13.6 0.1 0.065 13.6 0.1 1.1 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 GNT-I PF03071.15 CDF36013.1 - 0.0012 17.7 0.4 0.0029 16.4 0.4 1.6 1 1 0 1 1 1 1 GNT-I family DUF5484 PF17583.2 CDF36013.1 - 0.48 10.1 3.1 12 5.7 1.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5484) URO-D PF01208.17 CDF36015.1 - 1.5e-106 356.4 0.0 1.7e-106 356.3 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Acyltransferase PF01553.21 CDF36016.1 - 4.8e-15 55.4 0.0 8.5e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase DUF639 PF04842.12 CDF36017.1 - 1e-09 38.2 0.0 1.7e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) PRT_C PF08372.10 CDF36017.1 - 0.0002 21.2 0.3 0.2 11.4 0.0 2.4 2 0 0 2 2 2 2 Plant phosphoribosyltransferase C-terminal GRAM PF02893.20 CDF36017.1 - 0.0075 16.1 0.0 0.036 13.9 0.0 2.0 2 0 0 2 2 2 1 GRAM domain Pex24p PF06398.11 CDF36017.1 - 0.098 11.6 0.4 0.17 10.8 0.4 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Nop PF01798.18 CDF36020.1 - 5e-59 199.5 0.0 7.6e-59 199.0 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CDF36020.1 - 2e-23 83.6 2.6 2e-23 83.6 2.6 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain Fe_hyd_lg_C PF02906.14 CDF36021.1 - 1e-57 195.6 0.0 1.6e-57 195.0 0.0 1.3 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain DDE_3 PF13358.6 CDF36022.1 - 3.2e-18 65.9 0.0 4.1e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease AAA PF00004.29 CDF36023.1 - 7.8e-42 142.8 0.1 1.9e-41 141.6 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDF36023.1 - 3.9e-19 68.4 0.0 1.1e-18 66.9 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CDF36023.1 - 2.2e-10 40.4 4.3 5.9e-10 39.1 4.3 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 CDF36023.1 - 2.2e-06 27.4 0.0 5.6e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CDF36023.1 - 1.3e-05 25.0 0.0 2.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDF36023.1 - 1.4e-05 25.3 0.4 4.7e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDF36023.1 - 2e-05 25.0 0.1 0.00021 21.7 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDF36023.1 - 2.5e-05 24.6 0.3 0.0041 17.4 0.1 2.7 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.6 CDF36023.1 - 3.5e-05 23.9 0.3 0.0002 21.4 0.0 2.2 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 CDF36023.1 - 5.4e-05 23.0 0.0 0.0001 22.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 CDF36023.1 - 6.7e-05 22.9 0.0 0.00018 21.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDF36023.1 - 0.00023 20.5 0.2 0.00042 19.6 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 CDF36023.1 - 0.00049 19.4 0.0 0.00094 18.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 CDF36023.1 - 0.001 18.8 0.3 0.0037 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDF36023.1 - 0.0018 18.6 0.0 0.0054 17.1 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 CDF36023.1 - 0.0024 18.0 0.0 0.0082 16.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CDF36023.1 - 0.0051 17.2 0.2 0.019 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDF36023.1 - 0.012 16.2 0.6 0.012 16.2 0.6 2.8 2 1 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 CDF36023.1 - 0.015 15.0 0.0 0.4 10.4 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 CDF36023.1 - 0.019 14.9 0.0 0.87 9.5 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_7 PF12775.7 CDF36023.1 - 0.024 14.1 0.0 0.07 12.6 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 CDF36023.1 - 0.037 13.4 0.0 0.088 12.2 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CDF36023.1 - 0.095 12.0 0.4 11 5.3 0.0 2.5 1 1 1 2 2 2 0 KaiC PhoH PF02562.16 CDF36023.1 - 0.095 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 CDF36023.1 - 0.1 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 CDF36023.1 - 0.11 12.1 0.4 0.79 9.3 0.1 2.1 1 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDF36023.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin PF02224.18 CDF36023.1 - 0.13 11.9 0.3 0.31 10.7 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase TsaE PF02367.17 CDF36023.1 - 0.14 12.2 0.2 0.85 9.6 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CDF36023.1 - 0.32 10.9 5.7 1.9 8.3 0.0 3.2 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea 5_nucleotid_C PF02872.18 CDF36024.1 - 7.9e-41 139.9 0.0 2.1e-40 138.5 0.0 1.7 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CDF36024.1 - 1.8e-12 48.2 0.4 3e-12 47.5 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA PF00004.29 CDF36025.1 - 4.8e-16 59.4 0.0 8.3e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDF36025.1 - 8.3e-12 44.9 0.1 1.8e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 CDF36025.1 - 1.3e-06 28.1 0.0 3.2e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain MIT PF04212.18 CDF36025.1 - 0.00026 21.0 0.6 0.0009 19.3 0.6 2.0 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_16 PF13191.6 CDF36025.1 - 0.001 19.4 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain TPR_7 PF13176.6 CDF36025.1 - 0.012 15.6 0.4 0.041 13.9 0.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDF36025.1 - 0.038 13.9 0.6 0.16 11.9 0.6 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF36025.1 - 0.052 13.4 0.6 0.052 13.4 0.6 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat BACK PF07707.15 CDF36026.1 - 1.3e-17 63.8 0.3 2.2e-17 63.0 0.3 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch MATH PF00917.26 CDF36026.1 - 0.00069 19.8 0.1 0.0019 18.3 0.0 1.7 2 0 0 2 2 2 1 MATH domain PAC1 PF16094.5 CDF36026.1 - 1.4 8.0 5.9 2.3 7.3 5.9 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Peptidase_M17 PF00883.21 CDF36027.1 - 8.5e-96 320.9 0.0 1.1e-95 320.5 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain XAP5 PF04921.14 CDF36028.1 - 2.6e-80 269.8 4.9 2.6e-80 269.8 4.9 1.6 2 0 0 2 2 2 1 XAP5, circadian clock regulator TcdB_N PF12918.7 CDF36028.1 - 0.0034 17.7 1.9 0.0072 16.6 1.9 1.5 1 0 0 1 1 1 1 TcdB toxin N-terminal helical domain DUF4407 PF14362.6 CDF36028.1 - 0.016 14.6 7.1 0.025 13.9 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_L7Ae PF01248.26 CDF36029.1 - 1.4e-23 82.4 0.0 1.7e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family APP_Cu_bd PF12924.7 CDF36029.1 - 0.06 14.1 0.0 0.1 13.4 0.0 1.4 1 0 0 1 1 1 0 Copper-binding of amyloid precursor, CuBD Noc2 PF03715.13 CDF36030.1 - 4.2e-76 256.1 0.0 6.5e-76 255.4 0.0 1.3 1 0 0 1 1 1 1 Noc2p family LRR_8 PF13855.6 CDF36031.1 - 1.1e-42 143.6 54.8 2e-09 37.1 2.6 7.0 1 1 9 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 CDF36031.1 - 1.7e-42 142.7 29.5 8.1e-08 32.5 0.1 7.4 3 2 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDF36031.1 - 1.3e-20 73.6 15.3 2.2e-08 33.8 0.5 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 CDF36031.1 - 1.9e-07 30.6 34.1 3.1 8.7 0.2 11.0 9 3 2 11 11 11 4 Leucine Rich Repeat LRR_6 PF13516.6 CDF36031.1 - 1.7e-05 24.5 19.9 0.28 11.3 0.1 7.8 9 0 0 9 9 9 2 Leucine Rich repeat FTH PF01827.27 CDF36031.1 - 0.077 12.8 0.2 12 5.7 0.0 2.5 1 1 1 2 2 2 0 FTH domain LRR_12 PF18837.1 CDF36031.1 - 0.11 12.1 1.6 3.3 7.4 0.0 3.5 3 1 0 3 3 3 0 Leucine-rich repeat Lyase_8_N PF08124.11 CDF36031.1 - 0.14 11.0 0.1 0.24 10.3 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DIOX_N PF14226.6 CDF36032.1 - 2.7e-08 34.6 0.0 4.9e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CDF36032.1 - 0.00075 19.9 0.0 0.0012 19.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PseudoU_synth_2 PF00849.22 CDF36033.1 - 1.2e-24 87.2 0.1 1.6e-24 86.8 0.1 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase DBINO PF13892.6 CDF36035.1 - 0.09 13.1 0.0 0.097 13.0 0.0 1.2 1 0 0 1 1 1 0 DNA-binding domain SNF2_N PF00176.23 CDF36036.1 - 2.5e-69 233.7 0.2 3.8e-69 233.1 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 CDF36036.1 - 2.1e-37 127.6 2.2 2.1e-37 127.6 2.2 3.9 5 0 0 5 5 5 1 SLIDE Helicase_C PF00271.31 CDF36036.1 - 1.2e-18 67.5 0.0 6.7e-17 61.8 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF36036.1 - 8.4e-08 32.4 0.0 3.6e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF36036.1 - 2e-06 27.7 0.0 7.2e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CDF36036.1 - 0.00056 19.6 0.0 0.0016 18.2 0.0 1.7 1 0 0 1 1 1 1 SWI2/SNF2 ATPase KIP1 PF07765.12 CDF36036.1 - 0.13 12.4 6.8 0.25 11.5 1.3 3.3 3 0 0 3 3 3 0 KIP1-like protein Glycos_transf_2 PF00535.26 CDF36037.1 - 2.1e-06 27.7 0.1 5.5e-06 26.3 0.1 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDF36037.1 - 7.1e-05 22.8 0.3 0.11 12.3 0.1 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.6 CDF36037.1 - 0.0081 15.9 0.1 0.14 11.8 0.1 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family Aminotran_3 PF00202.21 CDF36038.1 - 1.1e-65 222.0 0.0 1.4e-65 221.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III ASC PF00858.24 CDF36039.1 - 6.2e-07 28.7 0.4 0.032 13.2 0.0 2.2 1 1 0 2 2 2 2 Amiloride-sensitive sodium channel Asn_synthase PF00733.21 CDF36041.1 - 2.5e-87 293.8 0.1 5.8e-55 187.4 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CDF36041.1 - 1.6e-30 105.5 0.0 2.5e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDF36041.1 - 5.2e-23 81.7 0.0 9.1e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDF36041.1 - 1.7e-06 27.7 0.0 2.7e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CDF36041.1 - 3.6e-06 26.3 0.0 6.1e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 CDF36041.1 - 0.0068 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Orn_Arg_deC_N PF02784.16 CDF36043.1 - 4.3e-51 173.7 0.0 5.6e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDF36043.1 - 3.7e-21 75.2 0.0 4.6e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 CDF36043.1 - 1.8e-06 27.8 0.0 4e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain EMC1_C PF07774.13 CDF36044.1 - 5.6e-36 124.2 0.0 9.5e-36 123.5 0.0 1.4 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CDF36044.1 - 2.3e-09 37.2 7.2 4.4e-05 23.2 0.1 2.8 1 1 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 CDF36044.1 - 0.0011 18.8 0.0 17 5.5 0.0 3.7 3 0 0 3 3 3 2 PQQ enzyme repeat BTB_2 PF02214.22 CDF36045.1 - 5.7e-14 52.2 0.0 1.8e-13 50.6 0.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain FAM110_C PF14160.6 CDF36045.1 - 0.028 15.5 0.1 0.049 14.7 0.1 1.4 1 0 0 1 1 1 0 Centrosome-associated C terminus Apt1 PF10351.9 CDF36047.1 - 6e-34 117.7 0.3 6e-34 117.7 0.3 3.6 3 1 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 CDF36047.1 - 2e-09 37.7 0.0 4.8e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF1478 PF07349.11 CDF36047.1 - 0.1 12.5 0.3 0.2 11.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1478) Not1 PF04054.15 CDF36049.1 - 6.5e-116 387.2 0.0 1.1e-115 386.5 0.0 1.3 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CDF36049.1 - 3.7e-76 255.5 0.1 1.4e-75 253.5 0.1 2.0 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 CDF36049.1 - 4.8e-49 166.1 1.4 1.6e-48 164.3 0.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 CDF36049.1 - 1.8e-44 151.2 0.0 4.5e-44 149.9 0.0 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 CDF36049.1 - 5.2e-19 68.8 0.2 1.2e-18 67.7 0.2 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat PMT PF02366.18 CDF36050.1 - 7.1e-42 143.7 8.9 7.1e-42 143.7 8.9 2.0 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CDF36050.1 - 7.5e-39 133.4 12.6 7.5e-39 133.4 12.6 2.2 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase Amino_oxidase PF01593.24 CDF36052.1 - 4e-70 237.3 0.0 4.6e-70 237.2 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF36052.1 - 2.5e-09 37.2 0.0 4.6e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain RE_NgoBV PF09564.10 CDF36052.1 - 0.058 12.8 0.1 0.099 12.1 0.1 1.3 1 0 0 1 1 1 0 NgoBV restriction endonuclease CLP_protease PF00574.23 CDF36053.1 - 0.029 14.2 0.2 0.039 13.8 0.2 1.1 1 0 0 1 1 1 0 Clp protease Kinesin_assoc PF16183.5 CDF36053.1 - 0.044 13.9 0.0 0.056 13.6 0.0 1.1 1 0 0 1 1 1 0 Kinesin-associated Herpes_UL25 PF01499.16 CDF36053.1 - 0.14 10.7 1.6 0.14 10.6 1.6 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family ParD_antitoxin PF03693.14 CDF36053.1 - 1.7 9.1 4.5 5.3 7.5 0.8 2.2 1 1 1 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH La PF05383.17 CDF36057.1 - 4.7e-15 55.4 0.0 7.5e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 La domain DUF5402 PF17393.2 CDF36057.1 - 0.25 11.3 0.0 0.47 10.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5402) PROCN PF08083.11 CDF36058.1 - 3.3e-219 727.6 8.4 5e-219 727.0 8.4 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CDF36058.1 - 1.3e-120 401.3 1.9 2.4e-120 400.4 0.3 2.0 2 0 0 2 2 2 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CDF36058.1 - 3.4e-83 277.4 2.7 9.4e-83 275.9 2.7 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CDF36058.1 - 1.2e-82 275.3 2.0 1.2e-82 275.3 2.0 2.6 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CDF36058.1 - 7.4e-70 233.2 0.0 1.6e-69 232.2 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 CDF36058.1 - 3.5e-47 159.3 0.0 9.4e-47 158.0 0.0 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 CDF36058.1 - 1.6e-43 146.9 0.5 4.4e-43 145.5 0.5 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 CDF36058.1 - 0.00032 20.7 0.0 0.00071 19.5 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease IGPS PF00218.21 CDF36064.1 - 1e-20 74.0 0.0 1.3e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase ADH_zinc_N PF00107.26 CDF36064.1 - 0.02 14.8 0.0 0.14 12.2 0.0 2.3 3 0 0 3 3 3 0 Zinc-binding dehydrogenase Fer2 PF00111.27 CDF36064.1 - 0.053 13.5 0.6 0.15 12.0 0.2 1.9 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain His_Phos_1 PF00300.22 CDF36065.1 - 1.2e-38 132.8 0.0 1.6e-33 116.0 0.0 2.3 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) GST_C_2 PF13410.6 CDF36066.1 - 2e-11 43.7 0.2 4.1e-11 42.7 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDF36066.1 - 1e-10 41.9 0.0 2.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDF36066.1 - 6.4e-09 35.9 0.1 2.7e-08 33.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDF36066.1 - 8e-08 32.5 0.0 1.5e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF36066.1 - 3.6e-07 30.4 0.0 7.9e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDF36066.1 - 2.2e-05 24.5 0.0 5.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GFO_IDH_MocA PF01408.22 CDF36067.1 - 1.2e-26 93.8 0.0 2.6e-26 92.8 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDF36067.1 - 6.1e-11 42.3 0.0 8.3e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Rossmann-like PF10727.9 CDF36067.1 - 0.0031 17.4 0.3 0.0076 16.1 0.1 1.7 2 0 0 2 2 2 1 Rossmann-like domain NAD_binding_3 PF03447.16 CDF36067.1 - 0.011 16.4 0.0 0.021 15.5 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDF36067.1 - 0.035 13.5 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DnaJ_CXXCXGXG PF00684.19 CDF36068.1 - 0.2 12.1 14.7 0.42 11.0 2.8 2.6 1 1 1 2 2 2 0 DnaJ central domain WzyE PF06899.11 CDF36068.1 - 0.25 10.2 0.0 0.32 9.9 0.0 1.1 1 0 0 1 1 1 0 WzyE protein, O-antigen assembly polymerase DUF1356 PF07092.12 CDF36068.1 - 1.3 8.2 5.5 3.8 6.7 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) DUF5351 PF17302.2 CDF36068.1 - 6 7.1 10.6 2.3 8.5 1.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5351) Anti-TRAP PF15777.5 CDF36068.1 - 9.7 6.2 11.4 3.7e+03 -2.0 11.4 2.6 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Spermine_synth PF01564.17 CDF36070.1 - 4.7e-66 221.8 0.0 8.3e-66 221.0 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CDF36070.1 - 3.7e-22 77.9 0.0 7e-22 77.1 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CDF36070.1 - 0.00033 21.3 0.0 0.00064 20.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF36070.1 - 0.018 15.8 0.0 0.049 14.4 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 CDF36070.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain YgbB PF02542.16 CDF36072.1 - 1.5e-60 204.0 0.8 2.8e-60 203.1 0.1 1.8 2 0 0 2 2 2 1 YgbB family PRA-PH PF01503.17 CDF36072.1 - 2.9e-14 53.2 0.0 8.7e-14 51.7 0.0 1.9 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF948 PF06103.11 CDF36072.1 - 0.091 13.0 0.8 0.26 11.6 0.0 2.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CLTH PF10607.9 CDF36072.1 - 0.2 11.5 0.0 0.47 10.3 0.0 1.6 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DUF4741 PF15897.5 CDF36074.1 - 0.071 12.9 0.2 0.078 12.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4741) DUF2344 PF10105.9 CDF36077.1 - 2.3e-39 135.0 0.0 4.1e-39 134.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2344) Radical_SAM PF04055.21 CDF36077.1 - 9.8e-11 42.3 0.0 2.9e-10 40.8 0.0 1.8 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 CDF36077.1 - 0.021 14.9 0.0 0.088 12.8 0.0 2.0 2 0 0 2 2 2 0 B12 binding domain zf-RING_2 PF13639.6 CDF36078.1 - 6.9e-10 39.1 4.7 1e-09 38.5 4.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF36078.1 - 2.5e-08 34.1 2.6 4.7e-08 33.2 2.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDF36078.1 - 5.7e-08 32.5 4.1 8.7e-08 31.9 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDF36078.1 - 1.1e-07 31.4 2.2 1.7e-07 30.7 2.2 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDF36078.1 - 1.6e-07 31.2 1.1 2.6e-07 30.6 1.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CDF36078.1 - 4.7e-07 29.5 5.9 7.2e-07 28.9 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF36078.1 - 6e-06 26.2 0.9 6e-06 26.2 0.9 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDF36078.1 - 1.8e-05 24.6 2.2 2.8e-05 24.0 2.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDF36078.1 - 3.8e-05 23.5 2.4 6.2e-05 22.8 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CDF36078.1 - 0.00023 21.2 4.2 0.0004 20.4 4.2 1.4 1 0 0 1 1 1 1 RING-variant domain zf-Nse PF11789.8 CDF36078.1 - 0.0011 18.7 0.8 0.002 17.9 0.8 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 CDF36078.1 - 0.0053 16.6 1.1 0.011 15.6 1.1 1.6 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 CDF36078.1 - 0.01 16.0 4.8 0.016 15.4 4.8 1.3 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CDF36078.1 - 0.017 14.9 1.0 0.032 14.0 1.0 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 CDF36078.1 - 0.033 14.0 8.0 0.95 9.4 8.1 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 CDF36078.1 - 0.044 13.8 3.1 0.13 12.4 3.1 1.8 1 1 0 1 1 1 0 Zinc-finger zf-RING_11 PF17123.5 CDF36078.1 - 0.12 12.1 1.7 0.29 10.9 1.7 1.6 1 0 0 1 1 1 0 RING-like zinc finger Cadherin_C_2 PF16492.5 CDF36078.1 - 0.14 12.9 0.5 0.55 11.0 0.0 2.0 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Orf78 PF06024.12 CDF36078.1 - 0.16 12.3 0.1 0.93 9.8 0.0 1.9 2 0 0 2 2 2 0 Orf78 (ac78) PHD PF00628.29 CDF36078.1 - 0.19 11.6 2.9 0.3 11.0 2.9 1.3 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 CDF36078.1 - 0.52 10.5 5.0 1.7 8.9 5.1 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 CDF36078.1 - 3.3 8.1 6.8 0.15 12.3 1.3 1.6 2 0 0 2 2 1 0 RING-like domain WD40 PF00400.32 CDF36080.1 - 8e-07 29.7 0.6 3.3 8.7 0.3 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.11 CDF36080.1 - 0.15 11.9 0.0 0.9 9.4 0.0 2.1 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A NIF PF03031.18 CDF36081.1 - 1.5e-49 167.7 0.9 2.2e-49 167.2 0.9 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Histone PF00125.24 CDF36084.1 - 1.3e-19 70.8 0.1 1.6e-19 70.5 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF36084.1 - 1.4e-06 28.4 1.1 4.5e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CDF36084.1 - 0.016 15.7 0.0 0.029 14.9 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 CDF36084.1 - 0.066 13.2 0.1 0.078 13.0 0.1 1.2 1 0 0 1 1 1 0 YscO-like protein Histone_H2A_C PF16211.5 CDF36085.1 - 6.4e-19 67.4 0.3 1.3e-18 66.4 0.3 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDF36085.1 - 8.2e-17 61.8 0.0 1.1e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF36085.1 - 0.0001 22.5 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Methyltransf_3 PF01596.17 CDF36086.1 - 9.4e-46 155.7 0.0 4.5e-45 153.4 0.0 2.1 2 1 0 2 2 2 1 O-methyltransferase UPF0176_N PF17773.1 CDF36086.1 - 3.3e-20 72.2 0.0 9.4e-20 70.8 0.0 1.9 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Methyltransf_24 PF13578.6 CDF36086.1 - 6.2e-14 52.9 0.1 9.8e-13 49.1 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Rhodanese_C PF12368.8 CDF36086.1 - 1.2e-10 41.6 10.7 2.5e-10 40.5 10.7 1.6 1 0 0 1 1 1 1 Rhodanase C-terminal Rhodanese PF00581.20 CDF36086.1 - 8.2e-08 32.7 0.0 3e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 Rhodanese-like domain PCMT PF01135.19 CDF36086.1 - 9.6e-06 25.5 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14 PF08704.10 CDF36086.1 - 0.012 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 CDF36086.1 - 0.067 13.0 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Evr1_Alr PF04777.13 CDF36087.1 - 5.9e-28 97.3 0.1 7.8e-28 96.9 0.1 1.2 1 0 0 1 1 1 1 Erv1 / Alr family Zn_ribbon_SprT PF17283.2 CDF36087.1 - 0.035 14.0 0.2 0.035 14.0 0.2 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain BP28CT PF08146.12 CDF36088.1 - 0.083 12.7 0.0 0.097 12.5 0.0 1.2 1 0 0 1 1 1 0 BP28CT (NUC211) domain HTH_41 PF14502.6 CDF36090.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_21 PF13304.6 CDF36091.1 - 0.12 12.2 0.1 0.17 11.7 0.1 1.3 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Peptidase_C48 PF02902.19 CDF36093.1 - 2.7e-27 96.0 0.3 6.5e-27 94.8 0.0 1.8 2 1 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain TetR_C_8 PF14278.6 CDF36093.1 - 0.064 13.4 0.2 0.18 11.9 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region Transthyretin PF00576.21 CDF36094.1 - 2.2e-36 124.9 0.0 2.5e-36 124.7 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family Coagulin PF02035.15 CDF36094.1 - 0.038 13.9 0.0 0.05 13.5 0.0 1.2 1 1 0 1 1 1 0 Coagulin Kelch_3 PF13415.6 CDF36095.1 - 2.7e-31 107.2 0.2 1.4e-08 34.8 0.0 7.2 7 0 0 7 7 7 4 Galactose oxidase, central domain RabGAP-TBC PF00566.18 CDF36095.1 - 1e-27 97.2 0.0 1.6e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Kelch_4 PF13418.6 CDF36095.1 - 1.7e-26 92.0 0.0 8.9e-05 22.4 0.0 6.9 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CDF36095.1 - 9.7e-26 89.3 1.4 0.00018 21.4 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 CDF36095.1 - 6.1e-20 70.8 0.1 0.00062 20.0 0.0 6.6 7 0 0 7 7 7 4 Kelch motif Kelch_1 PF01344.25 CDF36095.1 - 6.2e-18 64.1 0.8 2.6e-05 23.7 0.0 5.7 7 0 0 7 7 7 4 Kelch motif DUF4110 PF13422.6 CDF36095.1 - 1.5e-16 60.2 4.2 1.5e-16 60.2 4.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_2 PF07646.15 CDF36095.1 - 1.8e-16 59.3 3.0 0.025 14.6 0.0 6.3 6 1 0 6 6 6 4 Kelch motif WD40 PF00400.32 CDF36096.1 - 1.2e-06 29.1 11.3 0.21 12.5 0.1 5.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF36096.1 - 0.003 17.8 0.1 9.1 6.7 0.0 4.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CYTH PF01928.21 CDF36099.1 - 2.1e-13 50.6 0.1 3e-13 50.1 0.1 1.2 1 0 0 1 1 1 1 CYTH domain PSI PF01437.25 CDF36099.1 - 0.17 12.4 4.3 19 5.9 2.8 2.3 2 0 0 2 2 2 0 Plexin repeat HSP90 PF00183.18 CDF36100.1 - 2.5e-21 76.2 0.1 3.8e-21 75.6 0.0 1.4 1 1 0 1 1 1 1 Hsp90 protein Cwf_Cwc_15 PF04889.12 CDF36100.1 - 0.49 10.1 7.0 0.63 9.7 7.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 CDF36100.1 - 1.2 7.2 8.3 49 1.8 10.7 1.9 2 0 0 2 2 2 0 DNA polymerase phi HSP90 PF00183.18 CDF36101.1 - 3.1e-40 138.6 5.8 3.4e-40 138.4 5.8 1.0 1 0 0 1 1 1 1 Hsp90 protein ESM4 PF15952.5 CDF36101.1 - 0.025 15.0 0.8 0.032 14.6 0.8 1.3 1 0 0 1 1 1 0 Enhancer of split M4 family Retrotran_gag_2 PF14223.6 CDF36102.1 - 9.4e-33 112.8 0.3 2e-32 111.7 0.0 1.8 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF36102.1 - 2.5e-22 79.3 0.3 7.9e-22 77.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF36102.1 - 9.6e-08 31.8 0.0 2.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF36102.1 - 0.0014 18.4 0.0 0.0032 17.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Lipocalin PF00061.23 CDF36102.1 - 0.081 13.1 0.2 0.18 12.0 0.2 1.5 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family DDE_1 PF03184.19 CDF36103.1 - 1.4e-10 41.2 0.0 2.8e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Cecropin PF00272.19 CDF36103.1 - 0.11 12.2 1.3 0.37 10.5 1.3 1.9 1 0 0 1 1 1 0 Cecropin family DUF5421 PF17458.2 CDF36104.1 - 0.57 9.5 4.2 0.88 8.9 4.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) PMT_4TMC PF16192.5 CDF36110.1 - 1.1e-41 142.6 7.4 1.1e-41 142.6 7.4 2.4 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase PMT PF02366.18 CDF36110.1 - 2e-33 116.0 12.8 2e-33 116.0 12.8 1.7 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Acyl_transf_3 PF01757.22 CDF36112.1 - 6.5e-18 64.9 32.6 1.1e-17 64.2 32.6 1.3 1 0 0 1 1 1 1 Acyltransferase family HbrB PF08539.11 CDF36112.1 - 0.19 11.7 0.3 1.2 9.2 0.0 2.0 2 0 0 2 2 2 0 HbrB-like DUF4231 PF14015.6 CDF36112.1 - 3.1 8.3 0.0 3.1 8.3 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) Gp_dh_C PF02800.20 CDF36113.1 - 1.9e-70 235.5 0.1 2.6e-70 235.1 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDF36113.1 - 4.2e-38 129.8 0.0 1.4e-37 128.0 0.0 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDF36113.1 - 0.094 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.20 CDF36113.1 - 0.12 12.5 2.7 0.15 12.2 0.7 2.3 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Abhydrolase_1 PF00561.20 CDF36114.1 - 2.6e-17 63.3 0.0 3e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF36114.1 - 1e-07 32.8 0.0 1.3e-07 32.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family tRNA-synt_1d PF00750.19 CDF36114.1 - 0.25 10.2 0.1 0.4 9.6 0.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (R) DUF3537 PF12056.8 CDF36115.1 - 0.04 12.7 0.1 0.053 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) COX15-CtaA PF02628.15 CDF36115.1 - 0.046 12.8 0.0 0.058 12.5 0.0 1.1 1 0 0 1 1 1 0 Cytochrome oxidase assembly protein DUF3099 PF11298.8 CDF36115.1 - 0.058 13.5 0.2 0.11 12.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) RVT_3 PF13456.6 CDF36118.1 - 0.027 14.3 0.0 0.041 13.7 0.0 1.4 1 1 0 1 1 1 0 Reverse transcriptase-like Retrotran_gag_2 PF14223.6 CDF36119.1 - 2.2e-34 118.1 0.6 3.7e-34 117.4 0.6 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF36119.1 - 7.6e-22 77.7 0.1 2.7e-21 76.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CDF36119.1 - 0.00052 19.7 0.0 0.0018 18.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_6 PF15288.6 CDF36119.1 - 0.084 12.7 2.4 0.26 11.2 2.4 1.8 1 0 0 1 1 1 0 Zinc knuckle gag_pre-integrs PF13976.6 CDF36119.1 - 0.19 11.6 4.0 2.8 7.9 4.0 2.6 1 1 0 1 1 1 0 GAG-pre-integrase domain zf-CCHC PF00098.23 CDF36119.1 - 0.5 10.5 3.9 1.1 9.4 3.9 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF36119.1 - 0.51 10.1 2.2 1.8 8.4 2.2 2.0 1 0 0 1 1 1 0 Zinc knuckle ABC_tran PF00005.27 CDF36121.1 - 9.7e-12 45.6 0.0 1.1e-11 45.4 0.0 1.0 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF36121.1 - 0.00019 21.3 0.0 0.00019 21.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDF36121.1 - 0.00039 20.8 0.0 0.0004 20.8 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CDF36121.1 - 0.0014 18.7 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF36121.1 - 0.0017 18.3 0.1 0.0021 18.0 0.1 1.3 1 1 0 1 1 1 1 RsgA GTPase Zeta_toxin PF06414.12 CDF36121.1 - 0.0024 17.2 0.0 0.0025 17.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 CDF36121.1 - 0.0028 17.8 0.0 0.0028 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF36121.1 - 0.004 16.8 0.2 0.011 15.5 0.1 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDF36121.1 - 0.0064 16.8 0.0 0.0064 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDF36121.1 - 0.0077 16.0 0.0 0.0077 16.0 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 CDF36121.1 - 0.0079 15.9 0.0 0.0079 15.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDF36121.1 - 0.0095 16.2 0.0 0.0095 16.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CDF36121.1 - 0.017 15.0 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 CDF36121.1 - 0.04 14.5 0.0 0.04 14.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDF36121.1 - 0.049 14.1 0.2 0.055 14.0 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF36121.1 - 0.073 12.8 0.0 0.077 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF36121.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_10 PF12846.7 CDF36121.1 - 0.16 10.8 0.0 0.16 10.8 0.0 1.0 1 0 0 1 1 1 0 AAA-like domain Viral_helicase1 PF01443.18 CDF36121.1 - 0.17 11.6 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF87 PF01935.17 CDF36121.1 - 0.21 11.6 0.1 0.27 11.3 0.1 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain PIF1 PF05970.14 CDF36122.1 - 2.8e-90 303.1 0.0 4.3e-90 302.5 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF36122.1 - 1.4e-48 165.6 0.0 1.4e-48 165.6 0.0 2.3 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AMNp_N PF10423.9 CDF36122.1 - 0.14 11.8 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus bZIP_2 PF07716.15 CDF36125.1 - 0.013 15.6 20.2 0.027 14.5 20.2 1.5 1 0 0 1 1 1 0 Basic region leucine zipper DUF4451 PF14616.6 CDF36125.1 - 0.078 13.2 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) UPF0640 PF15114.6 CDF36125.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0640 TMF_TATA_bd PF12325.8 CDF36125.1 - 0.92 9.7 8.0 0.85 9.9 6.0 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 CDF36125.1 - 4.4 7.5 18.3 9.9 6.3 18.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor HSP20 PF00011.21 CDF36126.1 - 2.5e-14 53.2 1.1 1.8e-13 50.5 1.1 1.9 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDF36126.1 - 3.9e-05 23.1 0.2 0.00014 21.3 0.2 1.9 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Rep_1 PF01446.17 CDF36126.1 - 0.02 14.4 0.1 0.026 14.0 0.1 1.1 1 0 0 1 1 1 0 Replication protein bZIP_Maf PF03131.17 CDF36128.1 - 0.0023 18.4 7.2 0.0066 16.9 7.2 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor YabA PF06156.13 CDF36128.1 - 0.051 14.2 0.8 0.12 13.1 0.8 1.6 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_1 PF00170.21 CDF36128.1 - 0.67 10.1 20.1 3.2 7.9 20.1 2.2 1 1 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 CDF36128.1 - 0.74 9.9 19.4 3.2 7.9 19.1 2.2 1 1 0 1 1 1 0 Basic region leucine zipper SLX9 PF15341.6 CDF36128.1 - 7.8 6.9 8.8 18 5.7 4.7 2.2 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 HTH_Tnp_Tc3_1 PF11427.8 CDF36130.1 - 3.5e-08 33.2 0.0 7.6e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_32 PF13565.6 CDF36130.1 - 1.3e-05 25.7 2.2 4.7e-05 23.9 0.9 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 CDF36130.1 - 0.00045 19.9 0.2 0.0014 18.3 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 CDF36130.1 - 0.0049 16.9 0.5 0.079 13.0 0.1 2.5 1 1 1 2 2 2 1 Winged helix-turn helix ArsR PF09824.9 CDF36130.1 - 0.12 11.9 1.4 1.6 8.3 0.2 2.0 2 0 0 2 2 2 0 ArsR transcriptional regulator Helicase_C PF00271.31 CDF36131.1 - 1.7e-14 54.1 0.0 3.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF36131.1 - 1.1e-11 44.8 0.0 4e-11 43.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF36131.1 - 0.00036 20.6 0.0 0.00068 19.7 0.0 1.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 CDF36131.1 - 0.063 12.0 0.0 0.082 11.6 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF3638 PF12340.8 CDF36131.1 - 0.089 12.1 0.1 2.6 7.3 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3638) DDE_3 PF13358.6 CDF36132.1 - 6.2e-20 71.5 0.1 9.8e-20 70.8 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF36132.1 - 7.6e-08 32.1 0.0 1.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF36132.1 - 3.2e-07 30.0 0.1 5.8e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF36132.1 - 5.4e-05 22.9 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 CDF36132.1 - 0.003 18.1 1.0 3.6 8.3 0.0 2.7 1 1 1 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 CDF36132.1 - 0.006 16.6 0.3 0.018 15.1 0.2 1.9 1 1 0 1 1 1 1 Winged helix-turn helix Terminase_5 PF06056.12 CDF36132.1 - 0.05 13.5 0.3 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) V-ATPase_G PF03179.15 CDF36134.1 - 5.8e-25 87.8 12.0 6.4e-25 87.7 12.0 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 CDF36134.1 - 0.0075 15.7 8.6 0.0075 15.7 8.6 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) FPRL1_inhibitor PF16104.5 CDF36134.1 - 0.048 13.8 1.2 0.084 13.0 0.9 1.5 1 1 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein Suppressor_P21 PF11479.8 CDF36134.1 - 0.085 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA silencing suppressor P21 C-terminal domain SSURE PF11966.8 CDF36134.1 - 0.089 12.6 1.3 0.14 12.0 1.0 1.5 1 1 0 1 1 1 0 Fibronectin-binding repeat DivIVA PF05103.13 CDF36134.1 - 0.4 10.8 15.0 0.51 10.4 7.0 2.0 1 1 1 2 2 2 0 DivIVA protein CitMHS PF03600.16 CDF36137.1 - 1.8e-47 162.0 54.0 2.1e-36 125.7 31.2 3.1 2 1 1 3 3 3 3 Citrate transporter TrkA_C PF02080.21 CDF36137.1 - 1.2e-21 76.3 0.5 1.7e-10 40.5 0.1 2.4 2 0 0 2 2 2 2 TrkA-C domain Na_sulph_symp PF00939.19 CDF36137.1 - 3.3e-08 33.0 38.2 3.3e-05 23.1 6.4 4.0 2 2 2 4 4 4 3 Sodium:sulfate symporter transmembrane region TBPIP PF07106.13 CDF36140.1 - 3.1e-20 71.9 2.0 3.3e-20 71.8 0.4 1.9 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain Penicillinase_R PF03965.16 CDF36140.1 - 3.3e-07 30.7 1.1 4.3e-06 27.1 0.3 2.3 2 0 0 2 2 2 1 Penicillinase repressor LZ3wCH PF18517.1 CDF36140.1 - 5.1e-07 29.7 3.2 5.3e-07 29.6 1.2 2.2 2 0 0 2 2 2 1 Leucine zipper with capping helix domain HTH_12 PF08461.10 CDF36140.1 - 0.0001 22.2 0.0 0.00038 20.3 0.0 1.9 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain Mnd1 PF03962.15 CDF36140.1 - 0.00057 20.1 1.5 0.0035 17.6 0.2 2.3 2 0 0 2 2 2 1 Mnd1 HTH domain TrmB PF01978.19 CDF36140.1 - 0.0011 18.8 0.2 0.0031 17.4 0.1 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB GPP34 PF05719.11 CDF36140.1 - 0.0012 19.0 0.2 0.0016 18.6 0.2 1.2 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) MarR_2 PF12802.7 CDF36140.1 - 0.0056 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 MarR family Trimer_CC PF08954.11 CDF36140.1 - 0.0064 16.0 1.1 0.016 14.7 1.1 1.7 1 0 0 1 1 1 1 Trimerisation motif HTH_IclR PF09339.10 CDF36140.1 - 0.036 13.9 0.0 0.54 10.1 0.0 2.5 3 0 0 3 3 3 0 IclR helix-turn-helix domain MerR_2 PF13591.6 CDF36140.1 - 0.04 13.8 0.2 0.091 12.6 0.2 1.6 1 0 0 1 1 1 0 MerR HTH family regulatory protein Peptidase_C54 PF03416.19 CDF36140.1 - 0.04 13.3 0.2 0.059 12.8 0.2 1.3 1 1 0 1 1 1 0 Peptidase family C54 DUF910 PF06014.11 CDF36140.1 - 0.29 11.2 2.6 1.8 8.6 0.0 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF910) ZapB PF06005.12 CDF36140.1 - 0.62 10.6 6.0 1 9.8 4.2 2.2 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 CDF36140.1 - 1.1 9.1 8.6 0.1 12.4 1.1 2.9 2 2 2 4 4 4 0 Septum formation initiator ATP-synt PF00231.19 CDF36141.1 - 5.6e-63 213.3 0.1 8.8e-63 212.6 0.1 1.3 1 1 0 1 1 1 1 ATP synthase Aconitase_B_N PF11791.8 CDF36141.1 - 0.026 14.6 0.1 0.079 13.0 0.1 1.8 2 0 0 2 2 2 0 Aconitate B N-terminal domain Spore_IV_A PF09547.10 CDF36141.1 - 0.041 12.8 0.0 0.067 12.1 0.0 1.4 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) PEP-utilisers_N PF05524.13 CDF36141.1 - 0.45 10.7 4.4 9.8 6.4 0.5 2.6 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal LrgB PF04172.16 CDF36142.1 - 1.4e-24 86.8 13.3 1.4e-24 86.8 13.3 2.6 2 1 0 2 2 2 1 LrgB-like family LrgA PF03788.14 CDF36142.1 - 1.2e-06 28.4 6.2 1.2e-06 28.4 6.2 3.2 3 1 0 3 3 3 1 LrgA family MAPEG PF01124.18 CDF36143.1 - 1.8e-16 60.2 0.5 2.2e-16 59.9 0.5 1.1 1 0 0 1 1 1 1 MAPEG family Hint PF01079.20 CDF36145.1 - 1.6e-22 80.1 0.0 3.1e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Hint module MOSC_N PF03476.16 CDF36146.1 - 6.5e-13 48.6 0.0 2.2e-12 46.9 0.0 1.9 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 CDF36146.1 - 4.7e-10 39.0 0.0 2.6e-09 36.5 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V DDE_1 PF03184.19 CDF36147.1 - 6.5e-13 48.7 0.0 2.1e-12 47.1 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 CDF36147.1 - 0.012 16.2 0.4 0.066 13.8 0.4 2.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_ABP1_N PF18107.1 CDF36147.1 - 0.016 14.9 0.2 0.053 13.2 0.2 1.9 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 CDF36147.1 - 0.019 15.0 0.8 0.14 12.2 0.8 2.3 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain ING PF12998.7 CDF36148.1 - 1.8e-11 44.5 1.8 1.8e-11 44.5 0.4 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CDF36148.1 - 5.2e-06 26.3 7.1 8.6e-06 25.6 7.1 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CDF36148.1 - 0.014 15.7 0.6 0.034 14.4 0.6 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain CorA PF01544.18 CDF36148.1 - 0.031 13.6 0.8 4.9 6.4 0.1 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein LXG PF04740.12 CDF36148.1 - 0.063 13.0 1.5 0.1 12.3 1.5 1.3 1 0 0 1 1 1 0 LXG domain of WXG superfamily Prefoldin PF02996.17 CDF36148.1 - 0.56 10.1 2.9 2.3 8.2 0.2 2.6 3 0 0 3 3 3 0 Prefoldin subunit Troponin PF00992.20 CDF36148.1 - 5.1 7.4 9.5 0.45 10.8 3.6 2.1 2 2 0 2 2 2 0 Troponin Cofac_haem_bdg PF04187.13 CDF36153.1 - 1.9e-46 158.8 0.0 3.1e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN SKI PF01202.22 CDF36154.1 - 0.0036 17.4 0.0 1.3 9.1 0.0 2.4 2 1 0 2 2 2 2 Shikimate kinase AAA_33 PF13671.6 CDF36154.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDF36155.1 - 2.2e-89 296.7 0.0 3.1e-46 157.1 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF36155.1 - 8.8e-20 70.2 2.1 4.5e-09 36.0 0.1 2.9 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 CDF36155.1 - 1.9e-14 53.7 0.0 3.1e-06 27.0 0.0 3.1 4 0 0 4 4 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF36155.1 - 5.7e-13 49.6 2.7 0.00026 21.4 0.1 5.0 3 2 2 5 5 5 2 AAA ATPase domain AAA_5 PF07728.14 CDF36155.1 - 2.4e-10 40.5 0.0 0.0033 17.4 0.0 4.3 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF36155.1 - 1.4e-08 35.1 0.9 0.04 14.2 0.0 4.7 2 2 3 5 5 5 2 AAA domain AAA_2 PF07724.14 CDF36155.1 - 1.6e-08 34.8 0.0 0.00059 20.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CDF36155.1 - 1.7e-08 34.1 0.0 0.0019 17.5 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 CDF36155.1 - 3.8e-08 33.6 0.0 0.0074 16.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDF36155.1 - 5.3e-07 30.0 0.0 0.045 14.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 CDF36155.1 - 2e-06 27.4 0.7 0.05 13.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDF36155.1 - 2.1e-06 28.1 0.0 0.12 12.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CDF36155.1 - 2.4e-06 27.4 0.1 0.083 12.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 CDF36155.1 - 3.1e-06 27.2 0.0 0.096 12.7 0.0 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CDF36155.1 - 5.4e-06 27.0 0.2 0.11 13.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 CDF36155.1 - 6.9e-06 26.1 0.2 0.12 12.3 0.0 3.1 3 0 0 3 3 2 2 NACHT domain AAA_14 PF13173.6 CDF36155.1 - 1.4e-05 25.1 0.0 0.14 12.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 CDF36155.1 - 2.6e-05 24.8 0.0 0.55 10.8 0.0 3.0 2 0 0 2 2 2 2 ABC transporter Zeta_toxin PF06414.12 CDF36155.1 - 6.9e-05 22.2 0.1 0.14 11.4 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.6 CDF36155.1 - 9.6e-05 22.0 0.6 0.44 10.1 0.0 3.5 3 1 0 4 4 3 2 AAA domain Rad17 PF03215.15 CDF36155.1 - 0.00013 21.9 0.0 0.72 9.7 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain ATPase PF06745.13 CDF36155.1 - 0.00021 20.7 0.2 0.71 9.2 0.0 3.1 3 0 0 3 3 3 1 KaiC NB-ARC PF00931.22 CDF36155.1 - 0.00022 20.5 0.0 0.73 9.0 0.0 2.9 3 0 0 3 3 3 2 NB-ARC domain AAA_3 PF07726.11 CDF36155.1 - 0.00036 20.4 0.0 1 9.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 CDF36155.1 - 0.00037 20.9 0.6 1.1 9.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.26 CDF36155.1 - 0.0005 19.8 0.0 0.5 10.1 0.0 3.0 3 0 0 3 3 2 1 Sigma-54 interaction domain PhoH PF02562.16 CDF36155.1 - 0.00096 18.7 0.2 0.67 9.4 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein ATPase_2 PF01637.18 CDF36155.1 - 0.0014 18.5 0.0 0.61 10.0 0.0 3.2 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_11 PF13086.6 CDF36155.1 - 0.0026 17.6 0.4 2.5 7.8 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 CDF36155.1 - 0.0029 17.1 0.0 0.68 9.4 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 CDF36155.1 - 0.0064 16.2 0.1 1.4 8.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 CDF36155.1 - 0.0067 16.6 0.1 4.1 7.5 0.0 2.8 3 0 0 3 3 2 0 Cytidylate kinase-like family Parvo_NS1 PF01057.17 CDF36155.1 - 0.0077 15.3 0.0 3.8 6.5 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.18 CDF36155.1 - 0.0083 15.9 0.1 4.3 7.0 0.0 2.6 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 CDF36155.1 - 0.02 14.0 0.0 3.5 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Bac_DnaA PF00308.18 CDF36155.1 - 0.024 14.5 0.0 27 4.5 0.0 3.2 3 0 0 3 3 3 0 Bacterial dnaA protein Vps4_C PF09336.10 CDF36155.1 - 0.034 14.1 0.0 9.1 6.4 0.0 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Hydin_ADK PF17213.3 CDF36155.1 - 0.072 13.4 0.8 2.1 8.6 0.0 3.1 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Sigma54_activ_2 PF14532.6 CDF36155.1 - 0.076 13.1 0.1 3.1 7.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 CDF36155.1 - 0.088 12.7 0.0 12 5.8 0.0 2.9 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 CDF36155.1 - 0.11 12.8 0.2 25 5.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 CDF36155.1 - 0.12 11.5 0.0 10 5.2 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 CDF36155.1 - 0.15 11.3 0.1 13 4.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PduV-EutP PF10662.9 CDF36155.1 - 0.17 11.6 0.0 29 4.4 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Hydrolase_6 PF13344.6 CDF36156.1 - 2e-28 98.5 0.0 3.3e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF36156.1 - 1.6e-19 69.7 0.0 3.7e-19 68.6 0.0 1.6 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 CDF36156.1 - 6.9e-09 36.3 0.0 3.1e-08 34.2 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDF36156.1 - 2.5e-06 27.7 0.1 0.0009 19.4 0.0 2.6 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 CDF36156.1 - 0.00039 20.1 0.0 0.00066 19.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Acid_phosphat_B PF03767.14 CDF36156.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) DUF2608 PF11019.8 CDF36156.1 - 0.16 11.4 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Na_Ca_ex PF01699.24 CDF36158.1 - 4.6e-54 182.5 42.8 2e-28 99.2 19.2 3.1 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Spore_YabQ PF09578.10 CDF36158.1 - 0.0096 16.1 4.1 0.0096 16.1 4.1 4.3 5 0 0 5 5 5 1 Spore cortex protein YabQ (Spore_YabQ) DUF4713 PF15831.5 CDF36158.1 - 0.16 12.5 4.3 0.88 10.1 4.3 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) DUF3974 PF13120.6 CDF36158.1 - 0.31 11.2 0.0 0.31 11.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3974) DUF3377 PF11857.8 CDF36158.1 - 4.5 7.3 7.5 14 5.7 7.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4519 PF15012.6 CDF36158.1 - 5.1 7.3 7.1 19 5.5 7.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) ESF1 PF18209.1 CDF36163.1 - 0.0094 15.8 2.3 0.018 14.9 2.3 1.4 1 0 0 1 1 1 1 Embryo surrounding factor 1 Lectin_legB PF00139.19 CDF36165.1 - 1.1e-14 54.5 2.1 1.5e-14 54.1 2.1 1.1 1 0 0 1 1 1 1 Legume lectin domain Bact_lectin PF18483.1 CDF36165.1 - 0.0018 18.3 2.4 0.0026 17.8 2.4 1.2 1 0 0 1 1 1 1 Bacterial lectin SAICAR_synt PF01259.18 CDF36166.1 - 6.1e-73 245.5 0.0 8.4e-73 245.1 0.0 1.2 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.20 CDF36166.1 - 1.5e-36 125.2 0.4 6.7e-36 123.1 0.1 2.0 2 0 0 2 2 2 1 AIR carboxylase BTB PF00651.31 CDF36167.1 - 2.3e-14 53.5 0.1 2.1e-12 47.2 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain bZIP_1 PF00170.21 CDF36173.1 - 4.5e-07 29.9 6.4 8.5e-07 29.0 6.4 1.5 1 0 0 1 1 1 1 bZIP transcription factor CENP-Q PF13094.6 CDF36173.1 - 0.0074 16.5 1.5 0.012 15.8 1.5 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit bZIP_Maf PF03131.17 CDF36173.1 - 0.029 14.9 1.4 0.077 13.5 1.4 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_2 PF07716.15 CDF36173.1 - 0.031 14.4 2.8 0.031 14.4 2.8 1.9 2 0 0 2 2 2 0 Basic region leucine zipper DUF4472 PF14739.6 CDF36173.1 - 0.087 13.6 1.4 6.8 7.5 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) DUF4407 PF14362.6 CDF36173.1 - 1.8 7.9 7.1 2.4 7.4 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SesA PF17107.5 CDF36174.1 - 0.19 11.9 0.0 0.28 11.4 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Reticulon PF02453.17 CDF36175.1 - 0.067 13.1 0.5 2.8 7.9 0.1 2.3 2 0 0 2 2 2 0 Reticulon LapA_dom PF06305.11 CDF36175.1 - 1.5 8.7 4.2 7.1 6.5 0.1 2.9 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain PH PF00169.29 CDF36180.1 - 1.8e-05 25.2 0.0 3.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CDF36180.1 - 0.00018 21.7 0.0 0.00032 20.9 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Prim-Pol PF09250.11 CDF36180.1 - 0.0022 18.4 0.5 0.035 14.5 0.1 2.2 1 1 1 2 2 2 1 Bifunctional DNA primase/polymerase, N-terminal FAD_binding_8 PF08022.12 CDF36181.1 - 6.6e-20 71.2 0.0 1.5e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CDF36181.1 - 2.8e-12 47.0 0.0 1.9e-06 28.1 0.0 3.4 2 1 0 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CDF36181.1 - 6.1e-11 42.5 7.5 1.8e-10 41.0 7.5 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 CDF36181.1 - 0.00029 21.1 0.0 0.00061 20.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain KAR9 PF08580.10 CDF36181.1 - 9 4.7 11.2 12 4.2 11.2 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Corona_NS2 PF04753.12 CDF36182.1 - 0.39 11.3 4.7 1.2 9.8 4.7 2.0 1 0 0 1 1 1 0 Coronavirus non-structural protein NS2 CBM_20 PF00686.19 CDF36183.1 - 4.8e-41 138.6 0.0 2e-14 53.2 0.0 3.4 3 1 0 3 3 3 3 Starch binding domain DSPc PF00782.20 CDF36183.1 - 9.6e-18 64.3 0.0 1.6e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 CDF36183.1 - 9.6e-06 25.4 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Init_tRNA_PT PF04179.12 CDF36183.1 - 0.00037 20.8 0.0 0.00067 19.9 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 CDF36183.1 - 0.024 14.6 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 CDF36183.1 - 0.06 12.9 0.0 0.095 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Clostridium_P47 PF06597.11 CDF36184.1 - 0.14 10.8 0.0 0.25 10.0 0.0 1.3 1 0 0 1 1 1 0 Clostridium P-47 protein PIF1 PF05970.14 CDF36188.1 - 2.4e-78 263.8 0.0 3.5e-65 220.5 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF36188.1 - 2.1e-38 132.5 0.1 6.4e-35 121.1 0.0 2.4 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus PIF1 PF05970.14 CDF36189.1 - 2.5e-97 326.3 0.0 3.4e-96 322.6 0.0 2.1 1 1 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF36189.1 - 2.1e-59 200.9 0.0 2.1e-59 200.9 0.0 2.4 2 1 1 3 3 3 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF36189.1 - 1.3e-13 51.1 0.0 1.3e-13 51.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDF36189.1 - 0.026 14.9 0.0 0.07 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AMNp_N PF10423.9 CDF36189.1 - 0.062 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF36189.1 - 0.089 10.7 0.0 0.16 9.9 0.0 1.3 1 0 0 1 1 1 0 Helicase VWA PF00092.28 CDF36192.1 - 7.6e-06 26.3 0.2 0.019 15.2 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 CDF36192.1 - 0.046 14.4 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain Pro_isomerase PF00160.21 CDF36197.1 - 7.4e-33 114.1 0.0 1.2e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CDF36197.1 - 8.5e-12 44.7 0.0 1.7e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GDP_Man_Dehyd PF16363.5 CDF36198.1 - 3.2e-55 187.8 0.0 1.4e-54 185.8 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDF36198.1 - 1.6e-48 165.3 0.0 2.1e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDF36198.1 - 2e-11 43.5 0.0 2.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDF36198.1 - 2.3e-08 33.5 0.0 0.0013 18.0 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CDF36198.1 - 2.3e-07 30.2 0.0 0.00031 20.0 0.0 2.4 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein adh_short PF00106.25 CDF36198.1 - 0.001 18.6 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CDF36198.1 - 0.0058 15.8 0.0 0.0083 15.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CDF36198.1 - 0.046 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 KR domain NmrA PF05368.13 CDF36198.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family Glyoxalase PF00903.25 CDF36200.1 - 1.1e-19 70.9 1.2 3.2e-13 50.0 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDF36200.1 - 1.2e-11 44.9 0.1 0.00013 22.2 0.1 2.6 2 1 1 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CDF36200.1 - 1.1e-08 35.4 0.0 0.005 17.0 0.1 3.4 1 1 1 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 CDF36200.1 - 1.3e-05 25.4 0.2 7e-05 23.0 0.1 2.0 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_6 PF18029.1 CDF36200.1 - 0.063 14.1 0.0 0.33 11.8 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain Pirin PF02678.16 CDF36201.1 - 2.8e-12 46.6 0.0 5.1e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 CDF36201.1 - 5.6e-11 42.7 0.0 0.00053 20.3 0.0 2.6 3 0 0 3 3 3 2 Pirin C-terminal cupin domain Cupin_2 PF07883.11 CDF36201.1 - 0.049 13.3 0.0 3.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Cupin domain Aldo_ket_red PF00248.21 CDF36205.1 - 6.8e-53 179.8 0.0 8.1e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Chlorophyllase PF07224.11 CDF36205.1 - 0.13 11.3 0.1 2.9 6.8 0.1 2.1 1 1 0 1 1 1 0 Chlorophyllase Vps23_core PF09454.10 CDF36207.1 - 3.2e-11 43.0 0.8 5.7e-11 42.2 0.8 1.4 1 0 0 1 1 1 1 Vps23 core domain UEV PF05743.13 CDF36207.1 - 0.0019 18.1 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 UEV domain Abhydrolase_6 PF12697.7 CDF36208.1 - 7.8e-19 69.2 0.0 1.1e-18 68.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDF36208.1 - 1.8e-18 67.1 0.0 3.6e-15 56.3 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF36208.1 - 2.1e-11 43.6 0.0 1.3e-10 41.0 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 CDF36208.1 - 0.00087 19.4 0.0 0.0057 16.8 0.0 2.2 3 0 0 3 3 3 1 TAP-like protein LIDHydrolase PF10230.9 CDF36208.1 - 0.086 12.4 0.0 0.55 9.7 0.0 2.0 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Claudin_2 PF13903.6 CDF36209.1 - 3.2e-13 49.9 9.0 5.2e-13 49.2 9.0 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 CDF36209.1 - 3e-08 33.7 13.7 3.9e-06 26.9 13.7 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Trp_oprn_chp PF09534.10 CDF36209.1 - 0.072 12.9 4.7 0.51 10.1 2.3 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF973 PF06157.11 CDF36209.1 - 0.45 9.5 5.7 0.28 10.2 2.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF973) DUF1345 PF07077.11 CDF36209.1 - 2.9 7.6 9.9 0.18 11.5 2.0 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF1345) FtsX PF02687.21 CDF36209.1 - 9.2 6.8 13.1 22 5.6 9.2 2.7 2 1 0 2 2 2 0 FtsX-like permease family PhoLip_ATPase_C PF16212.5 CDF36210.1 - 5.4e-59 200.0 18.2 1e-58 199.1 18.2 1.5 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDF36210.1 - 1.3e-17 63.2 0.4 1.3e-17 63.2 0.4 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDF36210.1 - 1.5e-12 48.2 0.7 1e-06 29.2 0.2 3.7 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF36210.1 - 1.3e-08 34.8 0.0 3.4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDF36210.1 - 1.8e-05 24.4 0.2 0.0019 17.8 0.0 2.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDF36210.1 - 0.0001 22.2 0.0 0.00048 19.9 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Exo_endo_phos PF03372.23 CDF36211.1 - 6.3e-07 29.1 0.0 1.8e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Lipase_3 PF01764.25 CDF36212.1 - 4e-24 85.1 0.0 7.1e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.20 CDF36212.1 - 0.0052 16.9 0.0 0.0094 16.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CDF36212.1 - 0.0095 16.6 0.3 0.034 14.7 0.0 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family CbiG_N PF11760.8 CDF36212.1 - 0.035 14.1 0.1 0.083 12.9 0.1 1.5 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal DUF2974 PF11187.8 CDF36212.1 - 0.042 13.4 0.0 0.76 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 CDF36212.1 - 0.045 13.0 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Cytochrom_B561 PF03188.16 CDF36215.1 - 2.2e-09 37.5 5.9 4.2e-09 36.7 5.9 1.4 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Kelch_4 PF13418.6 CDF36215.1 - 4.9e-05 23.2 0.2 0.04 13.9 0.0 3.0 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CDF36215.1 - 0.0013 19.0 1.2 0.053 13.8 0.1 3.3 2 1 0 2 2 2 1 Galactose oxidase, central domain Ferric_reduct PF01794.19 CDF36215.1 - 0.0067 16.5 5.9 1 9.5 0.1 2.5 2 0 0 2 2 2 2 Ferric reductase like transmembrane component DUF2427 PF10348.9 CDF36215.1 - 4.3 7.2 10.8 0.17 11.7 2.6 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF2427) Pkinase PF00069.25 CDF36217.1 - 1.5e-64 217.9 0.0 2e-64 217.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36217.1 - 4.4e-27 95.0 0.0 6e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF36217.1 - 3.2e-05 23.1 0.0 4.2e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF36217.1 - 0.0071 15.7 0.1 0.02 14.2 0.1 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 CDF36217.1 - 0.075 12.9 1.6 2.7 7.8 0.7 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CDF36217.1 - 0.085 12.2 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family adh_short PF00106.25 CDF36218.1 - 4.4e-22 78.5 4.4 4.6e-12 45.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDF36218.1 - 5.1e-21 75.3 3.3 4.8e-14 52.5 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NIBRIN_BRCT_II PF16508.5 CDF36218.1 - 0.082 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Second BRCT domain on Nijmegen syndrome breakage protein CCT PF06203.14 CDF36220.1 - 1.8e-18 66.3 10.6 5e-18 64.9 10.6 1.7 1 0 0 1 1 1 1 CCT motif zf-B_box PF00643.24 CDF36220.1 - 9.5e-05 22.5 1.7 0.00016 21.7 1.7 1.3 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 CDF36220.1 - 0.019 15.2 2.6 0.034 14.4 2.6 1.4 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Herpes_DNAp_acc PF04929.12 CDF36220.1 - 0.46 9.4 3.1 0.66 8.9 3.1 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor mono-CXXC PF15626.6 CDF36220.1 - 4.2 7.8 8.1 2.6 8.5 2.4 2.9 2 0 0 2 2 2 0 single CXXC unit PMT PF02366.18 CDF36224.1 - 2.1e-36 125.7 7.2 2.1e-36 125.7 7.2 2.3 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CDF36224.1 - 1.1e-31 110.0 12.1 1.1e-31 110.0 12.1 2.5 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MLANA PF14991.6 CDF36224.1 - 0.09 13.1 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A Tweety PF04906.13 CDF36225.1 - 0.016 13.9 5.2 0.027 13.1 5.2 1.6 1 1 0 1 1 1 0 Tweety PMT_4TMC PF16192.5 CDF36225.1 - 0.08 12.5 1.4 0.25 10.9 1.4 1.8 1 0 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase adh_short PF00106.25 CDF36226.1 - 1.9e-28 99.3 0.0 2.7e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF36226.1 - 4.7e-28 98.3 0.0 6.6e-28 97.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF36226.1 - 1.1e-06 28.7 0.0 1.7e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 KR domain zf-C2H2 PF00096.26 CDF36227.1 - 7.8e-18 63.9 33.8 8.1e-05 22.9 1.2 6.1 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF36227.1 - 1.3e-12 47.4 41.2 0.0028 18.4 0.7 6.6 7 0 0 7 7 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF36227.1 - 9.7e-06 25.8 33.6 0.001 19.4 0.4 6.8 7 1 0 7 7 6 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 CDF36227.1 - 0.0026 17.5 24.3 0.28 11.0 2.9 5.4 5 0 0 5 5 5 3 C2H2-type zinc-finger domain zf-Di19 PF05605.12 CDF36227.1 - 0.0054 17.0 17.7 0.21 11.9 0.1 4.3 2 2 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 CDF36227.1 - 0.0058 16.9 9.0 0.12 12.6 3.4 2.7 2 0 0 2 2 2 1 C2H2-type zinc ribbon ADK_lid PF05191.14 CDF36227.1 - 0.0065 16.4 1.4 4.6 7.3 0.1 3.2 2 1 0 2 2 2 2 Adenylate kinase, active site lid Peptidase_S6 PF02395.16 CDF36227.1 - 0.01 13.9 0.9 0.014 13.4 0.9 1.1 1 0 0 1 1 1 0 Immunoglobulin A1 protease zf-C2H2_3rep PF18868.1 CDF36227.1 - 0.025 15.2 13.8 3.6 8.3 0.1 4.5 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 CDF36227.1 - 0.03 14.1 25.6 1.9 8.3 1.2 5.0 5 0 0 5 5 4 0 zinc-finger C2H2-type BolA PF01722.18 CDF36227.1 - 0.047 14.0 1.1 8.9 6.7 0.1 2.8 2 1 1 3 3 3 0 BolA-like protein zf-C2H2_jaz PF12171.8 CDF36227.1 - 0.081 13.2 0.2 0.4 11.0 0.1 5.5 7 0 0 7 7 6 0 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.14 CDF36227.1 - 0.12 12.3 2.7 8.7 6.4 0.1 2.9 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-CRD PF17979.1 CDF36227.1 - 0.4 10.8 12.9 0.2 11.8 0.7 3.1 2 1 2 4 4 4 0 Cysteine rich domain with multizinc binding regions zf-C2H2_9 PF16293.5 CDF36227.1 - 0.45 10.4 4.3 8.3 6.3 0.0 4.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) Zn-ribbon_8 PF09723.10 CDF36227.1 - 0.45 10.7 13.5 1.7 8.8 0.8 4.4 4 0 0 4 4 4 0 Zinc ribbon domain zf-met PF12874.7 CDF36227.1 - 0.51 10.8 21.1 0.63 10.5 0.2 5.8 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDF36227.1 - 0.65 10.4 15.4 6.6 7.1 0.2 4.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 CDF36227.1 - 0.74 9.5 4.8 15 5.3 0.1 3.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 CDF36227.1 - 0.98 9.5 7.6 2.9 8.0 1.1 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Actin_micro PF17003.5 CDF36227.1 - 4.4 6.4 9.7 1.1e+03 -1.5 9.7 3.1 1 1 0 1 1 1 0 Putative actin-like family Plant_tran PF04827.14 CDF36228.1 - 1.2e-83 279.7 0.2 1.6e-83 279.3 0.2 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF36228.1 - 6.4e-11 42.2 0.0 9.6e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Pox_F11 PF04943.12 CDF36229.1 - 0.0064 15.6 0.2 0.0064 15.6 0.2 1.0 1 0 0 1 1 1 1 Poxvirus F11 protein AraC_N PF06719.13 CDF36229.1 - 0.047 13.3 0.1 0.052 13.2 0.1 1.3 1 1 0 1 1 1 0 AraC-type transcriptional regulator N-terminus DUF3933 PF13069.6 CDF36229.1 - 0.09 12.7 0.2 0.14 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3933) ABC_membrane PF00664.23 CDF36232.1 - 9e-36 123.9 4.0 1.2e-35 123.5 4.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDF36232.1 - 2.8e-35 121.8 0.0 4.5e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDF36232.1 - 9.3e-06 25.2 0.2 0.00028 20.4 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CDF36232.1 - 0.0001 21.7 0.0 0.00025 20.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 CDF36232.1 - 0.00032 21.0 0.1 0.0019 18.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF36232.1 - 0.0022 18.4 0.7 0.0055 17.1 0.7 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CDF36232.1 - 0.016 15.0 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CDF36232.1 - 0.016 14.9 0.0 0.04 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 CDF36232.1 - 0.017 15.1 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 CDF36232.1 - 0.018 15.0 0.0 0.043 13.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_ATPase PF09818.9 CDF36232.1 - 0.029 13.2 0.1 0.051 12.4 0.1 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class SbcCD_C PF13558.6 CDF36232.1 - 0.03 14.6 0.7 0.3 11.3 0.7 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CDF36232.1 - 0.044 13.8 0.0 2.2 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CDF36232.1 - 0.061 12.5 0.0 0.091 11.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 CDF36232.1 - 0.062 13.1 0.1 1.9 8.2 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDF36232.1 - 0.063 13.0 3.5 0.68 9.6 3.5 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDF36232.1 - 0.083 13.1 0.6 0.29 11.4 0.4 2.0 1 1 0 1 1 1 0 AAA domain RNase_P_p30 PF01876.16 CDF36234.1 - 2.6e-20 72.8 0.0 3.6e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Ephrin_rec_like PF07699.13 CDF36236.1 - 4.4e-41 138.4 138.1 5.7e-11 42.0 3.7 16.5 7 6 10 17 17 17 15 Putative ephrin-receptor like NCD3G PF07562.14 CDF36236.1 - 3e-14 52.7 112.3 0.0059 16.5 5.9 14.9 9 6 6 15 15 15 11 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDF36236.1 - 0.033 14.6 1.3 0.033 14.6 1.3 18.5 10 5 8 18 18 18 0 TNFR/NGFR cysteine-rich region Glutaredoxin PF00462.24 CDF36237.1 - 2.2e-34 117.4 0.0 1.1e-17 64.0 0.0 2.5 2 0 0 2 2 2 2 Glutaredoxin SH3BGR PF04908.15 CDF36237.1 - 8.4e-06 25.9 0.0 0.0098 16.0 0.0 2.5 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein Thioredoxin PF00085.20 CDF36237.1 - 0.0066 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin GST_N_3 PF13417.6 CDF36237.1 - 0.032 14.7 0.0 7.7 7.0 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.16 CDF36240.1 - 3.5e-36 124.9 51.2 8.2e-34 117.1 26.9 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDF36240.1 - 4.9e-08 32.3 7.1 4.9e-08 32.3 7.1 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_4 PF06779.14 CDF36240.1 - 0.00042 19.7 20.2 0.00042 19.7 20.2 2.1 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB PsiA PF06952.11 CDF36241.1 - 0.077 12.2 2.8 0.095 11.9 2.8 1.1 1 0 0 1 1 1 0 PsiA protein GAGE PF05831.11 CDF36242.1 - 0.055 14.0 6.1 0.25 11.9 6.1 2.2 1 0 0 1 1 1 0 GAGE protein HAD_2 PF13419.6 CDF36242.1 - 0.14 12.3 4.5 0.11 12.6 0.5 2.9 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase Uteroglobin PF01099.17 CDF36242.1 - 6.1 7.3 8.2 1.2 9.5 0.3 3.5 3 0 0 3 3 3 0 Uteroglobin family AAA_23 PF13476.6 CDF36243.1 - 9.2e-18 65.5 0.0 1.1e-17 65.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDF36243.1 - 9.4e-07 28.5 0.0 1.2e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF36243.1 - 5.9e-06 25.9 0.0 1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CDF36243.1 - 7.6e-05 22.6 0.0 8.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CDF36243.1 - 0.00031 20.6 0.0 0.00041 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CDF36243.1 - 0.0052 15.9 0.0 0.0065 15.6 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 CDF36243.1 - 0.0085 16.5 0.1 0.013 15.9 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CDF36243.1 - 0.0094 15.7 0.1 0.015 15.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 CDF36243.1 - 0.02 14.5 0.1 0.028 14.0 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDF36243.1 - 0.022 15.1 0.1 0.035 14.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDF36243.1 - 0.047 14.2 0.0 0.066 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF36243.1 - 0.076 13.5 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 CDF36243.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 CDF36243.1 - 0.16 12.3 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AcrZ PF10766.9 CDF36245.1 - 0.028 14.0 0.1 0.051 13.2 0.1 1.4 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ Helicase_C PF00271.31 CDF36249.1 - 6.7e-08 32.9 0.0 1.5e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF36249.1 - 0.0047 16.7 0.0 0.049 13.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase EamA PF00892.20 CDF36250.1 - 4.3e-07 30.2 17.6 1.3e-06 28.6 17.6 1.9 1 1 0 1 1 1 1 EamA-like transporter family MFS_5 PF05631.14 CDF36253.1 - 6e-66 222.8 10.3 8.7e-66 222.2 10.3 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM DUF21 PF01595.20 CDF36253.1 - 9.9 5.8 14.7 4.2 7.1 1.6 3.8 4 0 0 4 4 4 0 Cyclin M transmembrane N-terminal domain UQ_con PF00179.26 CDF36254.1 - 5.6e-11 42.2 0.0 9.3e-10 38.3 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDF36254.1 - 0.00052 20.3 0.0 0.00078 19.7 0.0 1.4 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 CDF36254.1 - 0.07 12.8 0.0 0.38 10.5 0.0 2.2 2 0 0 2 2 2 0 Prokaryotic E2 family B CcmD PF04995.14 CDF36255.1 - 0.011 15.8 1.3 0.035 14.2 1.3 1.9 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) CcmD PF04995.14 CDF36258.1 - 0.01 15.9 1.3 0.01 15.9 1.3 1.6 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) WD40 PF00400.32 CDF36259.1 - 1.7e-78 256.5 46.5 3.1e-08 34.1 0.1 11.8 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF36259.1 - 1.8e-22 79.5 19.2 0.0027 18.0 0.0 10.5 1 1 9 10 10 10 7 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF36259.1 - 5.7e-15 55.2 0.0 9.9e-15 54.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain PQQ PF01011.21 CDF36259.1 - 1.8e-07 30.8 0.0 6.6 6.9 0.0 7.7 9 0 0 9 9 9 1 PQQ enzyme repeat Nup160 PF11715.8 CDF36259.1 - 7e-07 28.3 18.0 9 4.8 0.1 10.1 6 3 3 11 11 11 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF36259.1 - 6.4e-06 25.4 3.0 12 4.7 0.0 7.2 2 2 7 9 9 9 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF36259.1 - 7.2e-06 26.3 35.7 2.7 8.6 0.1 10.5 7 3 4 11 11 11 4 PQQ-like domain WD40_like PF17005.5 CDF36259.1 - 0.0018 17.6 0.0 12 5.1 0.0 5.1 6 1 0 7 7 7 1 WD40-like domain AAA_22 PF13401.6 CDF36259.1 - 0.0029 17.9 0.0 0.0082 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Peptidase_S9_N PF02897.15 CDF36259.1 - 0.065 12.0 9.0 1.3 7.8 0.2 5.2 1 1 2 5 5 5 0 Prolyl oligopeptidase, N-terminal beta-propeller domain WSC PF01822.19 CDF36259.1 - 0.096 12.9 0.0 0.32 11.2 0.0 1.8 1 0 0 1 1 1 0 WSC domain PQQ_2 PF13360.6 CDF36259.1 - 1.4 8.4 46.5 12 5.3 25.1 3.7 1 1 2 3 3 3 0 PQQ-like domain JmjC PF02373.22 CDF36261.1 - 5.3e-09 36.5 0.1 1.1e-08 35.6 0.1 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase TauE PF01925.19 CDF36264.1 - 0.046 13.4 1.5 0.071 12.7 1.5 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE DUF2207 PF09972.9 CDF36264.1 - 0.14 10.9 0.0 0.32 9.7 0.0 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Peptidase_C50 PF03568.17 CDF36266.1 - 9.5e-63 212.6 1.0 4.9e-49 167.5 0.0 2.8 1 1 1 2 2 2 2 Peptidase family C50 CHAT PF12770.7 CDF36266.1 - 0.0069 15.8 0.0 0.84 9.0 0.0 2.6 1 1 1 2 2 2 2 CHAT domain Sec6 PF06046.13 CDF36267.1 - 2.3e-30 105.5 0.0 3.8e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 SchA_CurD PF04486.12 CDF36267.1 - 0.055 13.6 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 SchA/CurD like domain Phos_pyr_kin PF08543.12 CDF36269.1 - 1.6e-17 63.8 0.0 2e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CDF36269.1 - 3.7e-08 33.0 0.2 7.5e-08 32.0 0.2 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase B56 PF01603.20 CDF36270.1 - 1.4e-142 475.5 0.0 1.8e-142 475.2 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DGCR6 PF07324.11 CDF36270.1 - 0.17 11.5 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein BRK PF07533.16 CDF36272.1 - 7e-23 80.0 2.5 1e-11 44.3 0.5 2.4 2 0 0 2 2 2 2 BRK domain Ribosomal_S13_N PF08069.12 CDF36272.1 - 0.11 12.6 1.9 8.4 6.5 0.1 3.3 3 0 0 3 3 3 0 Ribosomal S13/S15 N-terminal domain Trehalase PF01204.18 CDF36276.1 - 3.3e-118 395.7 0.0 4e-118 395.4 0.0 1.0 1 0 0 1 1 1 1 Trehalase DUF679 PF05078.12 CDF36277.1 - 0.071 13.1 0.9 0.086 12.8 0.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF679) DUF5489 PF17592.2 CDF36277.1 - 0.076 13.6 0.4 0.12 13.0 0.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5489) PHO4 PF01384.20 CDF36280.1 - 4.2e-122 407.4 7.7 5e-122 407.2 7.7 1.0 1 0 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 CDF36280.1 - 0.0047 16.7 0.3 1.7 8.5 0.1 2.6 2 0 0 2 2 2 2 IclR helix-turn-helix domain Plant_tran PF04827.14 CDF36284.1 - 1.9e-68 230.1 1.6 1.3e-65 220.8 1.6 2.1 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF36284.1 - 4.9e-05 23.0 0.0 0.00016 21.4 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF3379 PF11859.8 CDF36284.1 - 0.018 14.4 1.1 0.025 13.9 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) GNT-I PF03071.15 CDF36285.1 - 2.5e-28 99.0 0.1 2.8e-28 98.8 0.1 1.0 1 0 0 1 1 1 1 GNT-I family Glycos_transf_1 PF00534.20 CDF36288.1 - 5.8e-33 113.9 0.0 1.1e-32 112.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF36288.1 - 1.4e-27 96.8 0.0 2.6e-27 95.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDF36288.1 - 4.6e-27 95.1 0.6 9.4e-27 94.1 0.5 1.6 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDF36288.1 - 5.1e-19 69.3 0.0 1.2e-18 68.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 CDF36288.1 - 1.3e-16 61.1 1.4 5.4e-10 39.4 0.2 2.5 1 1 1 2 2 2 2 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.6 CDF36288.1 - 3.6e-06 27.0 0.1 7e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CDF36288.1 - 7.5e-06 26.3 0.0 1.5e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.13 CDF36288.1 - 0.022 13.3 0.1 0.035 12.7 0.1 1.2 1 0 0 1 1 1 0 Glycogen synthase Ribul_P_3_epim PF00834.19 CDF36288.1 - 0.11 11.8 1.4 4.3 6.7 0.9 2.1 2 0 0 2 2 2 0 Ribulose-phosphate 3 epimerase family Myb_DNA-binding PF00249.31 CDF36289.1 - 8e-10 38.8 0.0 1.4e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF36289.1 - 0.03 14.2 0.2 0.087 12.7 0.2 1.8 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 CDF36289.1 - 0.035 14.3 0.1 0.073 13.3 0.1 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain SdiA-regulated PF06977.11 CDF36293.1 - 0.031 13.5 0.0 7.9 5.6 0.0 3.0 3 0 0 3 3 3 0 SdiA-regulated PIF1 PF05970.14 CDF36294.1 - 7.6e-87 291.8 0.0 1.2e-52 179.3 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF36294.1 - 2.7e-59 200.6 0.0 4.4e-59 199.9 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF36294.1 - 1.3e-12 47.9 0.0 2.4e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF36294.1 - 0.013 15.9 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-DNL PF05180.12 CDF36294.1 - 0.042 13.8 0.3 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 DNL zinc finger AAA_11 PF13086.6 CDF36294.1 - 0.15 11.9 0.2 5.8 6.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 CDF36295.1 - 6.5e-39 133.4 0.0 3.2e-38 131.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF36295.1 - 1.3e-10 40.9 0.0 2.7e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 CDF36295.1 - 4.5e-06 27.0 0.5 0.0014 18.9 0.2 3.2 2 1 0 2 2 1 1 AAA domain AAA_25 PF13481.6 CDF36295.1 - 5.9e-06 26.0 0.3 0.017 14.7 0.2 2.5 1 1 0 2 2 2 2 AAA domain TIP49 PF06068.13 CDF36295.1 - 2.1e-05 23.9 0.0 7.5e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 CDF36295.1 - 5.2e-05 23.3 0.3 0.0011 18.9 0.1 2.9 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 CDF36295.1 - 9.8e-05 22.3 0.0 0.00026 20.9 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 CDF36295.1 - 0.00016 21.5 0.0 0.00053 19.8 0.0 1.7 1 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDF36295.1 - 0.0004 20.5 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 CDF36295.1 - 0.00042 20.4 0.0 0.0013 18.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF36295.1 - 0.00092 19.8 0.0 0.0018 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain MIT PF04212.18 CDF36295.1 - 0.0012 18.8 0.4 0.0032 17.5 0.4 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain IstB_IS21 PF01695.17 CDF36295.1 - 0.0019 18.0 0.0 0.0039 16.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CDF36295.1 - 0.0027 18.1 4.5 0.0028 18.1 0.3 3.0 3 1 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 CDF36295.1 - 0.0031 16.7 0.0 0.0067 15.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 CDF36295.1 - 0.0047 16.4 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 CDF36295.1 - 0.0056 16.1 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CDF36295.1 - 0.0074 15.7 0.3 1.2 8.5 0.1 2.3 1 1 1 2 2 2 1 KaiC AAA_24 PF13479.6 CDF36295.1 - 0.022 14.5 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 CDF36295.1 - 0.03 13.4 0.0 0.059 12.5 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 CDF36295.1 - 0.032 14.8 0.0 0.12 12.9 0.0 1.9 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 CDF36295.1 - 0.038 13.2 0.3 8.3 5.5 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain TniB PF05621.11 CDF36295.1 - 0.042 13.2 0.0 7.6 5.9 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein RNA_helicase PF00910.22 CDF36295.1 - 0.057 13.8 0.0 0.21 12.0 0.0 2.1 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 CDF36295.1 - 0.069 13.3 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CDF36295.1 - 0.072 12.8 0.3 0.49 10.1 0.0 2.5 3 2 1 4 4 2 0 Sigma-54 interaction domain PhoH PF02562.16 CDF36295.1 - 0.1 12.0 0.2 0.21 11.0 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 CDF36295.1 - 0.12 12.8 2.5 0.78 10.1 0.3 2.5 2 1 0 2 2 2 0 AAA domain DUF2786 PF10979.8 CDF36295.1 - 2.6 8.0 5.4 2.6 8.0 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) Ribosomal_L7Ae PF01248.26 CDF36297.1 - 5.2e-20 71.0 0.5 9.5e-20 70.1 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Clathrin PF00637.20 CDF36299.1 - 4.1e-157 516.3 1.0 5.8e-25 87.8 0.0 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 CDF36299.1 - 1.5e-23 82.4 0.0 1.1e-22 79.7 0.0 2.6 2 0 0 2 2 2 1 Clathrin-H-link TPR_14 PF13428.6 CDF36299.1 - 0.00044 20.8 6.3 12 7.0 0.0 7.6 8 0 0 8 8 6 1 Tetratricopeptide repeat DUF1717 PF05414.11 CDF36299.1 - 0.004 17.6 1.4 0.019 15.4 0.0 2.6 3 0 0 3 3 2 1 Viral domain of unknown function (DUF1717) TPR_7 PF13176.6 CDF36299.1 - 0.0084 16.1 6.4 3 8.1 0.1 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF36299.1 - 0.014 15.5 0.0 66 4.1 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Mic1 PF07035.12 CDF36299.1 - 0.017 14.9 2.6 0.55 9.9 0.3 3.1 3 0 0 3 3 3 0 Colon cancer-associated protein Mic1-like TPR_19 PF14559.6 CDF36299.1 - 0.02 15.4 1.9 20 5.8 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF36299.1 - 0.029 14.6 1.1 39 4.6 0.0 5.1 6 0 0 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDF36299.1 - 0.058 13.8 0.0 16 6.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF36299.1 - 0.12 12.6 10.1 59 4.1 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Pox_A3L PF05288.11 CDF36299.1 - 0.14 12.2 0.2 4.3 7.4 0.0 2.7 2 0 0 2 2 2 0 Poxvirus A3L Protein CRM1_C PF08767.11 CDF36303.1 - 1.9e-100 336.1 2.2 1.3e-99 333.5 0.1 2.4 2 0 0 2 2 2 1 CRM1 C terminal CRM1_repeat_2 PF18784.1 CDF36303.1 - 1.5e-35 120.6 0.7 6e-35 118.7 0.7 2.1 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 Xpo1 PF08389.12 CDF36303.1 - 2.6e-34 118.4 0.1 1.8e-33 115.7 0.0 2.5 3 0 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_3 PF18787.1 CDF36303.1 - 1.6e-27 95.4 2.1 1.6e-27 95.4 2.1 2.6 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 CDF36303.1 - 3.1e-16 58.6 0.3 7.3e-16 57.4 0.3 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat RNA_pol_Rpb5_C PF01191.19 CDF36304.1 - 3e-34 116.7 0.2 5.2e-34 116.0 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 CDF36304.1 - 9.4e-20 71.0 0.4 1.9e-19 70.0 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain Prefoldin PF02996.17 CDF36305.1 - 3.3e-27 94.8 0.1 4.5e-27 94.3 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Lebercilin PF15619.6 CDF36305.1 - 0.016 14.9 1.8 0.76 9.4 0.1 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4201 PF13870.6 CDF36305.1 - 0.023 14.4 1.1 5 6.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) HR1 PF02185.16 CDF36305.1 - 0.035 14.2 1.1 0.071 13.2 0.1 2.1 2 1 0 2 2 2 0 Hr1 repeat DUF1664 PF07889.12 CDF36305.1 - 0.035 14.1 1.4 1.2 9.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 CDF36305.1 - 0.042 13.8 0.2 14 5.7 0.0 2.6 2 1 1 3 3 3 0 Prefoldin subunit ATP-synt_D PF01813.17 CDF36305.1 - 0.05 13.4 0.1 0.067 13.0 0.1 1.2 1 0 0 1 1 1 0 ATP synthase subunit D CCDC144C PF14915.6 CDF36305.1 - 0.071 12.2 1.4 3.1 6.8 0.2 2.1 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region COG2 PF06148.11 CDF36305.1 - 0.16 12.0 1.3 1.7 8.8 0.2 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Seryl_tRNA_N PF02403.22 CDF36305.1 - 0.29 11.4 1.6 1.1 9.5 0.5 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Sec7 PF01369.20 CDF36306.1 - 1.3e-59 201.0 0.0 1.9e-59 200.4 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CDF36306.1 - 0.00012 22.0 2.9 0.0059 16.5 0.0 4.0 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal VGPC1_C PF16799.5 CDF36306.1 - 0.19 11.7 0.8 0.91 9.6 0.3 2.2 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 FAM176 PF14851.6 CDF36306.1 - 0.28 10.8 3.9 22 4.7 4.0 3.3 2 1 0 2 2 2 0 FAM176 family CDC45 PF02724.14 CDF36309.1 - 6.3 5.0 14.9 10 4.3 14.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Alpha-amylase_C PF02806.18 CDF36317.1 - 9.3e-20 70.9 0.2 2.6e-19 69.5 0.2 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 CDF36317.1 - 8e-13 48.6 0.0 2.5e-12 47.0 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CDF36317.1 - 2.4e-11 43.8 0.7 2.4e-11 43.8 0.7 2.3 2 1 1 3 3 3 1 Alpha amylase, catalytic domain 6PF2K PF01591.18 CDF36318.1 - 1.1e-74 250.6 0.1 1.4e-74 250.1 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CDF36318.1 - 2.7e-38 131.6 0.0 6.3e-38 130.4 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CDF36318.1 - 3.2e-05 24.1 0.0 5.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 CDF36318.1 - 0.0079 16.0 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein KTI12 PF08433.10 CDF36318.1 - 0.042 13.3 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.20 CDF36318.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Ribosomal_L39 PF00832.20 CDF36319.1 - 0.061 13.0 1.0 0.061 13.0 1.0 2.0 1 1 1 2 2 2 0 Ribosomal L39 protein FoP_duplication PF13865.6 CDF36319.1 - 0.77 10.3 5.4 2 9.0 5.4 1.7 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 PEN-2 PF10251.9 CDF36320.1 - 1.8e-12 47.5 1.5 2.8e-12 46.9 1.5 1.3 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase 7tm_3 PF00003.22 CDF36320.1 - 0.0072 16.1 0.0 0.0088 15.8 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4199 PF13858.6 CDF36320.1 - 0.049 14.0 0.3 0.075 13.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) adh_short PF00106.25 CDF36321.1 - 1.9e-31 109.1 0.0 2.5e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF36321.1 - 1.9e-24 86.5 0.0 2.5e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF36321.1 - 2.3e-08 34.2 0.0 3.4e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDF36321.1 - 0.0018 18.2 0.0 0.0028 17.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CDF36321.1 - 0.0093 15.0 0.1 0.012 14.6 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ADH_zinc_N PF00107.26 CDF36321.1 - 0.036 14.0 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RraA-like PF03737.15 CDF36321.1 - 0.14 12.3 0.8 0.28 11.3 0.8 1.6 1 1 0 1 1 1 0 Aldolase/RraA GIT_SHD PF08518.11 CDF36321.1 - 0.15 11.7 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 Spa2 homology domain (SHD) of GIT Epimerase PF01370.21 CDF36321.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family WD40 PF00400.32 CDF36322.1 - 0.019 15.8 6.8 3.3 8.7 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat Hint PF01079.20 CDF36324.1 - 3.8e-12 46.2 0.2 6.2e-12 45.5 0.2 1.3 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.6 CDF36324.1 - 2.3e-05 24.7 0.4 0.016 15.5 0.0 2.2 2 0 0 2 2 2 2 Hint domain CUE PF02845.16 CDF36325.1 - 1.2e-07 31.3 0.0 2.2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 CUE domain TIR_2 PF13676.6 CDF36327.1 - 6.3e-15 55.8 0.0 1.6e-14 54.5 0.0 1.8 2 0 0 2 2 2 1 TIR domain TIR PF01582.20 CDF36327.1 - 4.1e-08 33.2 0.0 6.3e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR-like PF10137.9 CDF36327.1 - 0.013 15.4 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Sel1 PF08238.12 CDF36329.1 - 3.6e-11 43.3 0.2 0.068 13.9 0.0 3.1 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.6 CDF36329.1 - 0.042 14.5 0.2 2.9 8.7 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat VirK PF06903.12 CDF36329.1 - 0.13 12.4 0.0 5 7.3 0.0 2.1 2 0 0 2 2 2 0 VirK protein TPR_17 PF13431.6 CDF36329.1 - 0.16 12.4 0.0 3.9 8.1 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat NSP11 PF06471.12 CDF36331.1 - 0.0046 15.5 0.0 0.0053 15.3 0.0 1.1 1 0 0 1 1 1 1 NSP11 Ig_3 PF13927.6 CDF36331.1 - 0.03 14.9 0.3 0.18 12.4 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Sel1 PF08238.12 CDF36333.1 - 0.025 15.3 0.1 0.057 14.1 0.0 1.6 2 0 0 2 2 2 0 Sel1 repeat DUF2497 PF10691.9 CDF36335.1 - 0.02 15.3 0.0 0.19 12.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) CC PF04942.14 CDF36335.1 - 1.3 9.3 4.1 4.6 7.5 0.0 2.7 2 1 0 2 2 2 0 CC domain MFS_1 PF07690.16 CDF36336.1 - 2.6e-15 56.2 37.9 2.6e-15 56.2 37.9 2.7 1 1 2 3 3 3 2 Major Facilitator Superfamily TIR_2 PF13676.6 CDF36337.1 - 1.2e-11 45.2 0.0 2.5e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF36337.1 - 0.00022 21.1 0.0 0.00051 19.9 0.0 1.6 1 0 0 1 1 1 1 TIR domain Latarcin PF10279.9 CDF36337.1 - 0.027 14.9 0.5 0.092 13.2 0.3 2.0 2 0 0 2 2 2 0 Latarcin precursor TIR-like PF10137.9 CDF36337.1 - 0.061 13.3 0.1 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain TonB_N PF16031.5 CDF36337.1 - 0.17 12.4 11.6 0.53 10.8 11.6 1.8 1 0 0 1 1 1 0 TonB polyproline region TIR_2 PF13676.6 CDF36338.1 - 1.9e-12 47.8 0.0 4.3e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF36338.1 - 4.8e-06 26.5 0.0 9.3e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 TIR domain 7TM_GPCR_Srt PF10321.9 CDF36339.1 - 0.17 10.8 0.0 0.17 10.8 0.0 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srt S-AdoMet_synt_C PF02773.16 CDF36340.1 - 1.3e-61 206.6 0.0 1.5e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain AMPK1_CBM PF16561.5 CDF36342.1 - 3.6e-16 59.1 0.1 8e-16 58.0 0.1 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase TPR_12 PF13424.6 CDF36342.1 - 9.1e-13 48.3 8.2 0.00061 20.0 0.1 4.5 4 1 2 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDF36342.1 - 9.7e-09 34.7 3.2 0.018 14.8 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF36342.1 - 2.8e-07 30.8 4.3 0.55 11.2 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDF36342.1 - 9.9e-07 28.5 4.0 0.28 11.5 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF36342.1 - 5.6e-06 26.1 9.4 0.041 14.0 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36342.1 - 8.9e-06 26.3 1.9 0.0038 17.8 0.1 4.3 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF36342.1 - 1.2e-05 25.7 2.1 0.078 13.5 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDF36342.1 - 1.2e-05 25.0 6.1 0.17 11.8 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_3 PF07720.12 CDF36342.1 - 4.7e-05 23.3 4.1 0.0024 17.8 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF36342.1 - 6.6e-05 22.7 1.4 9.1 6.6 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDF36342.1 - 0.00035 20.1 2.4 0.0035 16.8 0.0 2.2 2 0 0 2 2 2 1 MalT-like TPR region CBM_48 PF02922.18 CDF36342.1 - 0.0012 19.2 0.0 0.0027 18.0 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) TPR_11 PF13414.6 CDF36342.1 - 0.0023 17.6 0.3 0.22 11.2 0.0 3.0 2 0 0 2 2 2 1 TPR repeat ANAPC3 PF12895.7 CDF36342.1 - 0.013 15.7 1.2 1.3 9.3 0.1 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 CDF36342.1 - 0.014 14.8 0.4 0.97 8.8 0.2 2.2 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 CDF36342.1 - 0.019 15.3 0.8 0.91 10.0 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF410 PF04190.13 CDF36342.1 - 0.22 11.3 0.8 2.5 7.8 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF410) TPR_6 PF13174.6 CDF36342.1 - 3 8.7 4.3 85 4.1 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat W2 PF02020.18 CDF36343.1 - 2e-16 59.9 0.3 4.4e-16 58.8 0.3 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon SurA_N PF09312.11 CDF36343.1 - 0.00045 20.3 0.1 0.0012 18.8 0.1 1.7 1 0 0 1 1 1 1 SurA N-terminal domain AstE_AspA PF04952.14 CDF36343.1 - 0.097 11.7 0.4 0.13 11.3 0.4 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family AIG1 PF04548.16 CDF36346.1 - 6e-09 35.5 0.1 2.7e-06 26.9 0.1 2.2 2 0 0 2 2 2 2 AIG1 family AAA_22 PF13401.6 CDF36346.1 - 0.24 11.7 1.1 2.8 8.2 0.3 2.8 2 1 0 2 2 2 0 AAA domain Sugar-bind PF04198.13 CDF36348.1 - 0.14 11.3 0.1 0.35 10.0 0.0 1.6 2 0 0 2 2 2 0 Putative sugar-binding domain adh_short_C2 PF13561.6 CDF36350.1 - 3e-53 180.8 2.4 4e-53 180.4 2.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDF36350.1 - 5.1e-41 140.3 0.5 6.2e-41 140.0 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDF36350.1 - 1.2e-07 31.8 0.7 1.6e-07 31.4 0.7 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CDF36350.1 - 0.00015 21.3 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Hint PF01079.20 CDF36351.1 - 8.4e-23 81.0 0.0 1.4e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 Hint module Mucin PF01456.17 CDF36351.1 - 0.0014 18.6 12.3 0.0014 18.6 12.3 2.8 2 1 0 2 2 2 1 Mucin-like glycoprotein Hint_2 PF13403.6 CDF36351.1 - 0.013 15.8 0.0 1.1 9.5 0.0 2.5 1 1 1 2 2 2 0 Hint domain Vint PF14623.6 CDF36351.1 - 0.062 13.1 0.0 0.09 12.6 0.0 1.2 1 0 0 1 1 1 0 Hint-domain Dicty_REP PF05086.12 CDF36351.1 - 0.46 8.4 12.0 0.62 8.0 12.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4637 PF15470.6 CDF36353.1 - 3.2 7.5 5.7 3.4 7.4 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) NOA36 PF06524.12 CDF36353.1 - 4.7 6.4 11.9 4 6.7 11.9 1.2 1 0 0 1 1 1 0 NOA36 protein Glyco_transf_7C PF02709.14 CDF36354.1 - 2.3e-08 33.6 0.2 5.1e-08 32.5 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase NodZ PF05830.11 CDF36354.1 - 9.5e-07 27.9 0.0 0.01 14.7 0.0 2.5 2 0 0 2 2 2 2 Nodulation protein Z (NodZ) Glyco_tranf_2_2 PF10111.9 CDF36354.1 - 2.1e-06 27.4 0.0 0.00021 20.8 0.1 2.3 1 1 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDF36354.1 - 2.3e-05 24.3 0.0 4.7e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 O-FucT PF10250.9 CDF36354.1 - 0.00013 21.8 0.1 0.0009 19.0 0.1 2.0 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF2336 PF10098.9 CDF36354.1 - 0.018 14.5 0.7 0.03 13.8 0.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) Glyco_tranf_2_3 PF13641.6 CDF36354.1 - 0.025 14.5 0.2 0.19 11.6 0.1 2.4 2 1 0 2 2 2 0 Glycosyltransferase like family 2 XG_FTase PF03254.13 CDF36354.1 - 0.09 11.4 0.0 7.2 5.1 0.0 2.2 2 0 0 2 2 2 0 Xyloglucan fucosyltransferase SH3_3 PF08239.11 CDF36354.1 - 0.13 12.6 0.0 0.36 11.1 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain Ion_trans PF00520.31 CDF36356.1 - 1.8e-35 122.4 39.2 1.8e-26 92.9 16.7 2.2 2 0 0 2 2 2 2 Ion transport protein EF-hand_7 PF13499.6 CDF36356.1 - 0.13 12.7 0.4 0.28 11.7 0.4 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 CDF36356.1 - 0.24 11.3 1.6 0.5 10.2 1.6 1.5 1 0 0 1 1 1 0 EF-hand domain pair RNA_pol_Rpc34 PF05158.12 CDF36357.1 - 4.2e-54 184.2 7.4 2.1e-36 126.0 1.4 2.9 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit Suv3_N PF18114.1 CDF36357.1 - 0.12 12.5 0.3 0.33 11.1 0.2 1.8 2 0 0 2 2 2 0 Suv3 helical N-terminal domain EGF_Tenascin PF18720.1 CDF36358.1 - 0.054 13.6 5.6 0.19 11.8 5.6 1.9 1 0 0 1 1 1 0 Tenascin EGF domain Laminin_EGF PF00053.24 CDF36358.1 - 0.13 12.4 3.2 0.33 11.1 3.2 1.7 1 0 0 1 1 1 0 Laminin EGF domain Exostosin PF03016.15 CDF36359.1 - 4.6e-51 173.8 0.0 5.7e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Glyco_transf_64 PF09258.10 CDF36360.1 - 7.5e-42 143.3 0.0 1.1e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Glyco_transf_8 PF01501.20 CDF36360.1 - 1e-16 61.3 0.5 5.6e-15 55.6 0.5 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CDF36360.1 - 0.021 14.8 0.0 0.065 13.2 0.0 1.8 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase LCAT PF02450.15 CDF36361.1 - 3e-14 53.0 0.0 2.6e-11 43.3 0.0 2.1 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 CDF36361.1 - 0.00032 21.4 1.8 0.00048 20.8 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 CDF36361.1 - 0.00043 20.2 0.1 0.0051 16.7 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase RuvX PF03652.15 CDF36363.1 - 0.048 14.1 0.0 0.11 12.9 0.0 1.9 1 1 0 1 1 1 0 Holliday junction resolvase PDGLE PF13190.6 CDF36364.1 - 0.18 11.7 1.0 2.1 8.3 1.0 2.4 1 1 0 1 1 1 0 PDGLE domain Copine PF07002.16 CDF36365.1 - 3.6e-66 222.7 0.0 5.2e-66 222.2 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 CDF36365.1 - 1.3e-05 25.4 0.0 0.00089 19.5 0.0 2.7 2 0 0 2 2 2 1 C2 domain vWA-TerF-like PF10138.9 CDF36365.1 - 3.3e-05 24.1 0.1 7.5e-05 22.9 0.1 1.5 2 0 0 2 2 2 1 vWA found in TerF C terminus Dynamin_N PF00350.23 CDF36366.1 - 3.3e-23 82.6 0.1 1.6e-22 80.4 0.0 2.1 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 CDF36366.1 - 2.6e-18 66.2 1.1 4.5e-18 65.5 1.1 1.4 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 CDF36366.1 - 7.4e-06 26.0 0.1 0.00011 22.3 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF36366.1 - 0.06 12.9 0.1 3.1 7.3 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B BLI1 PF17324.2 CDF36366.1 - 7.2 7.3 8.8 2 9.1 0.2 3.3 4 0 0 4 4 4 0 BLOC-1 interactor 1 DLH PF01738.18 CDF36368.1 - 4.9e-30 104.7 0.0 5.5e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CDF36368.1 - 0.00015 21.3 0.1 0.00035 20.1 0.0 1.6 1 1 1 2 2 2 1 Prolyl oligopeptidase family DUF1876 PF08962.11 CDF36368.1 - 0.0025 17.7 0.0 0.0094 15.9 0.0 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1876) ATP-synt_DE PF00401.20 CDF36368.1 - 0.062 13.6 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain BAAT_C PF08840.11 CDF36368.1 - 0.11 12.4 0.0 0.79 9.6 0.0 2.2 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal adh_short PF00106.25 CDF36370.1 - 1.7e-35 122.2 0.0 3.1e-35 121.4 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF36370.1 - 4e-22 78.9 0.0 6.5e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF36370.1 - 7.2e-13 48.8 0.0 1.2e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDF36370.1 - 0.0052 16.3 0.1 0.008 15.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family CoA_binding_2 PF13380.6 CDF36370.1 - 0.011 16.2 0.0 2 8.9 0.0 2.5 2 1 0 2 2 2 0 CoA binding domain NAD_binding_3 PF03447.16 CDF36370.1 - 0.086 13.5 0.1 0.24 12.1 0.0 1.8 2 1 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Rod-binding PF10135.9 CDF36370.1 - 0.31 11.6 2.5 0.88 10.2 0.2 2.5 2 0 0 2 2 2 0 Rod binding protein FMN_dh PF01070.18 CDF36375.1 - 7.1e-115 383.7 0.0 8e-115 383.6 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CDF36375.1 - 3.9e-06 26.1 0.4 0.00011 21.4 0.2 2.5 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CDF36375.1 - 2.3e-05 23.8 1.2 0.0016 17.8 0.2 2.2 1 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 CDF36375.1 - 3.4e-05 23.2 0.4 5.2e-05 22.6 0.4 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase PA PF02225.22 CDF36375.1 - 0.029 14.4 0.9 0.66 10.0 0.1 2.7 3 0 0 3 3 3 0 PA domain DHO_dh PF01180.21 CDF36375.1 - 0.041 13.1 0.0 0.51 9.5 0.0 2.3 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase His_biosynth PF00977.21 CDF36375.1 - 0.042 13.3 0.1 0.14 11.6 0.1 1.9 1 1 1 2 2 2 0 Histidine biosynthesis protein NMO PF03060.15 CDF36375.1 - 0.079 12.3 4.4 0.062 12.7 1.7 1.9 2 0 0 2 2 2 0 Nitronate monooxygenase IGPS PF00218.21 CDF36375.1 - 0.2 10.8 0.0 0.35 10.0 0.0 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase Epimerase PF01370.21 CDF36376.1 - 3.1e-08 33.4 0.0 3.7e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CDF36376.1 - 3e-07 30.1 0.0 1.3e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CDF36376.1 - 0.025 13.7 0.0 0.043 12.9 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain BT1 PF03092.16 CDF36377.1 - 2.7e-107 359.2 16.7 9.7e-74 248.5 5.6 2.0 1 1 1 2 2 2 2 BT1 family WD40 PF00400.32 CDF36378.1 - 2.2e-20 72.6 11.4 0.011 16.6 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF36378.1 - 3.7e-06 27.1 0.3 0.11 12.9 0.1 4.1 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Branch PF02485.21 CDF36379.1 - 3.6e-37 128.2 2.3 5.1e-37 127.7 2.3 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme RuBisCO_large_N PF02788.16 CDF36379.1 - 0.16 12.2 0.4 0.36 11.0 0.4 1.6 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain Plant_tran PF04827.14 CDF36381.1 - 8.9e-62 208.3 0.1 1.1e-61 208.0 0.1 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF36381.1 - 2e-13 50.3 0.0 2.8e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CDF36381.1 - 0.065 12.9 0.1 2.5 7.7 0.0 2.2 1 1 0 2 2 2 0 Transposase DDE domain dCMP_cyt_deam_1 PF00383.23 CDF36383.1 - 3e-27 94.4 0.5 4.9e-27 93.8 0.5 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDF36383.1 - 1.5e-13 50.7 0.0 2.7e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 CDF36383.1 - 0.00015 22.3 0.0 0.00029 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Yippee-Mis18 PF03226.14 CDF36384.1 - 2.5e-13 50.1 0.1 3e-13 49.9 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CDF36384.1 - 0.049 13.9 0.1 0.067 13.4 0.1 1.2 1 0 0 1 1 1 0 C-terminal domain of RIG-I Amnionless PF14828.6 CDF36384.1 - 0.091 11.6 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Amnionless Nbas_N PF15492.6 CDF36385.1 - 0.1 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Ribosomal_S13 PF00416.22 CDF36386.1 - 5.2e-22 78.6 0.0 3.8e-20 72.6 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Pyr_redox_2 PF07992.14 CDF36387.1 - 1.8e-66 224.4 0.2 2.6e-66 223.8 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDF36387.1 - 1.2e-31 109.2 1.9 2.3e-31 108.3 1.9 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDF36387.1 - 2.1e-19 69.9 3.0 2.2e-17 63.3 0.0 3.1 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDF36387.1 - 2.2e-15 56.7 1.8 1.3e-13 50.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF36387.1 - 4.6e-08 32.2 0.9 0.0056 15.4 0.0 3.1 3 0 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 CDF36387.1 - 5.5e-05 22.7 4.1 0.00065 19.2 0.2 2.8 2 1 0 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CDF36387.1 - 6e-05 22.3 0.0 0.01 15.0 0.0 2.2 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 CDF36387.1 - 0.0072 15.5 5.0 0.018 14.2 2.8 2.5 2 1 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDF36387.1 - 0.021 13.9 3.8 0.28 10.2 1.8 2.8 3 0 0 3 3 3 0 FAD binding domain 3HCDH_N PF02737.18 CDF36387.1 - 0.061 13.2 0.7 3.1 7.6 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 CDF36387.1 - 0.073 13.1 0.0 0.073 13.1 0.0 2.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CDF36387.1 - 0.2 10.7 0.8 6.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 CDF36387.1 - 1.1 9.6 6.6 0.11 12.7 1.8 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pkinase PF00069.25 CDF36388.1 - 4.9e-66 222.8 0.0 5.8e-66 222.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36388.1 - 1.9e-33 115.9 0.0 2.3e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF36388.1 - 6.1e-08 32.3 0.0 8.8e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF36388.1 - 3.4e-05 23.3 0.0 5.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDF36388.1 - 0.019 14.5 0.3 0.032 13.8 0.0 1.4 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 CDF36388.1 - 0.023 14.6 0.1 0.033 14.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PfkB PF00294.24 CDF36390.1 - 2.5e-43 148.5 0.1 3.1e-42 144.9 0.1 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase PHD PF00628.29 CDF36391.1 - 2e-10 40.4 0.9 3.9e-10 39.5 0.9 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CDF36391.1 - 0.0022 17.5 1.0 0.0046 16.5 1.0 1.5 1 0 0 1 1 1 1 PHD-finger zf-RanBP PF00641.18 CDF36391.1 - 0.033 13.5 0.9 0.076 12.3 0.3 1.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-RING_2 PF13639.6 CDF36391.1 - 0.16 12.4 3.0 0.41 11.0 3.0 1.7 1 0 0 1 1 1 0 Ring finger domain zf-4CXXC_R1 PF10497.9 CDF36391.1 - 0.16 12.2 0.3 0.16 12.2 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_9 PF13901.6 CDF36391.1 - 0.16 11.9 2.6 0.19 11.7 0.2 2.0 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon C1_1 PF00130.22 CDF36391.1 - 0.39 10.6 0.1 0.39 10.6 0.1 2.7 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PPP5 PF08321.12 CDF36393.1 - 2.1e-27 95.2 0.1 4.7e-27 94.1 0.1 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region Metallophos PF00149.28 CDF36393.1 - 4e-27 96.1 0.3 6.2e-27 95.4 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_2 PF07719.17 CDF36393.1 - 3.9e-05 23.4 3.6 0.061 13.5 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDF36393.1 - 0.02 14.7 4.3 0.61 10.0 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36393.1 - 0.029 15.0 3.8 0.34 11.6 0.5 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDF36393.1 - 0.25 11.7 2.0 4 7.9 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat SNF5 PF04855.12 CDF36395.1 - 5.2e-12 46.1 0.1 2.1e-11 44.1 0.0 1.9 1 1 1 2 2 2 1 SNF5 / SMARCB1 / INI1 TMEM247 PF15444.6 CDF36395.1 - 0.049 13.7 2.2 0.079 13.0 2.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 CDRT4 PF15213.6 CDF36395.1 - 0.91 10.1 4.3 0.24 12.0 0.6 2.0 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein PQ-loop PF04193.14 CDF36396.1 - 2.6e-16 59.1 9.1 6.2e-08 32.3 0.8 2.8 3 0 0 3 3 3 2 PQ loop repeat CbtB PF09489.10 CDF36396.1 - 3.5 7.8 4.3 1.9 8.7 0.1 2.5 2 1 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) ATG11 PF10377.9 CDF36398.1 - 0.0047 17.0 0.1 0.0049 16.9 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 11 ATP_synt_H PF05493.13 CDF36402.1 - 3.1e-21 75.6 0.5 3.4e-21 75.5 0.5 1.0 1 0 0 1 1 1 1 ATP synthase subunit H Hum_adeno_E3A PF05393.11 CDF36402.1 - 0.0025 17.7 0.1 0.0027 17.7 0.1 1.2 1 0 0 1 1 1 1 Human adenovirus early E3A glycoprotein DUF3149 PF11346.8 CDF36402.1 - 0.0046 16.6 0.4 0.059 13.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3149) YqhR PF11085.8 CDF36402.1 - 0.025 14.5 1.0 0.029 14.3 1.0 1.1 1 0 0 1 1 1 0 Conserved membrane protein YqhR ECF_trnsprt PF12822.7 CDF36402.1 - 0.036 14.2 0.6 0.039 14.1 0.6 1.0 1 0 0 1 1 1 0 ECF transporter, substrate-specific component DUF5527 PF17665.1 CDF36402.1 - 0.078 12.5 1.2 0.098 12.2 1.2 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5527) ABC2_membrane_3 PF12698.7 CDF36402.1 - 0.11 11.6 1.4 0.11 11.6 1.4 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1129 PF06570.11 CDF36402.1 - 0.13 11.8 0.5 0.13 11.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) CPP1-like PF11833.8 CDF36402.1 - 0.15 11.7 2.2 0.16 11.6 2.2 1.0 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like TssN PF17555.2 CDF36402.1 - 0.21 10.9 1.4 0.22 10.9 1.4 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssN WD40 PF00400.32 CDF36403.1 - 1.5e-05 25.6 1.6 0.22 12.4 0.1 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF36403.1 - 9.9e-05 22.6 0.5 0.032 14.5 0.0 3.6 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CCAP PF11105.8 CDF36403.1 - 0.065 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a RbsD_FucU PF05025.13 CDF36403.1 - 0.088 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 RbsD / FucU transport protein family Ndufs5 PF10200.9 CDF36404.1 - 8.5e-05 22.7 0.3 0.00011 22.4 0.3 1.3 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3536 PF12055.8 CDF36404.1 - 0.0028 17.0 0.4 0.0031 16.9 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3536) COX6B PF02297.17 CDF36404.1 - 0.18 12.0 9.6 0.1 12.9 2.9 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Phage_holin_2_4 PF16082.5 CDF36404.1 - 0.26 11.0 2.6 0.36 10.6 2.6 1.3 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like DUF3128 PF11326.8 CDF36404.1 - 0.42 11.0 10.0 3 8.3 10.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) UPF0203 PF05254.12 CDF36404.1 - 0.54 10.6 6.6 5 7.5 6.6 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) polyprenyl_synt PF00348.17 CDF36405.1 - 2.1e-68 230.2 0.0 2.6e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 CDF36405.1 - 0.0075 15.9 0.1 0.012 15.2 0.1 1.3 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 HA2 PF04408.23 CDF36406.1 - 9.3e-22 77.4 0.2 3.3e-21 75.6 0.0 2.1 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDF36406.1 - 1.8e-16 60.3 0.0 3.7e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDF36406.1 - 3.6e-15 56.2 0.0 9.1e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF36406.1 - 7.1e-08 32.4 0.1 1.4e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CDF36406.1 - 0.00019 21.2 0.0 0.00049 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 CDF36406.1 - 0.00074 19.5 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 CDF36406.1 - 0.00082 19.7 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CDF36406.1 - 0.0079 16.2 0.0 3.5 7.6 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDF36406.1 - 0.014 15.7 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CDF36406.1 - 0.021 14.1 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IATP PF04568.12 CDF36406.1 - 0.042 14.3 1.3 0.15 12.5 0.5 2.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP T2SSE PF00437.20 CDF36406.1 - 0.087 11.9 0.0 0.21 10.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Yuri_gagarin PF15934.5 CDF36406.1 - 4.8 7.0 7.0 11 5.8 7.0 1.5 1 0 0 1 1 1 0 Yuri gagarin bZIP_1 PF00170.21 CDF36407.1 - 1.1e-07 31.8 4.2 1.1e-07 31.8 4.2 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CDF36407.1 - 0.0001 22.3 6.5 0.0001 22.3 6.5 1.9 2 0 0 2 2 2 1 Basic region leucine zipper DUF1640 PF07798.11 CDF36407.1 - 2.4 8.2 5.5 0.47 10.5 0.8 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1640) Glyco_tran_28_C PF04101.16 CDF36408.1 - 1.1e-21 77.6 0.0 1.2e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain RtcB PF01139.17 CDF36409.1 - 4.4e-25 88.7 0.0 4.9e-25 88.6 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB GNT-I PF03071.15 CDF36409.1 - 0.13 11.0 0.0 0.14 10.9 0.0 1.0 1 0 0 1 1 1 0 GNT-I family RtcB PF01139.17 CDF36410.1 - 1.9e-31 109.7 0.5 2.1e-31 109.5 0.5 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Cu-oxidase_4 PF02578.15 CDF36410.1 - 0.00016 21.3 0.5 0.00016 21.3 0.5 1.2 1 1 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase rve PF00665.26 CDF36411.1 - 6.2e-22 78.0 0.1 5.1e-21 75.1 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF36411.1 - 8.9e-08 31.9 0.0 2.4e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF36411.1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF36411.1 - 0.043 13.6 1.5 0.16 11.7 1.5 2.0 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF36411.1 - 0.18 11.9 4.0 0.35 11.0 4.0 1.5 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH PF17917.1 CDF36412.1 - 1.2e-32 112.3 0.0 1.8e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF36412.1 - 9e-31 105.9 0.0 1.4e-30 105.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF36412.1 - 4.5e-05 23.1 0.0 7.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RIFIN PF02009.16 CDF36413.1 - 0.18 11.6 5.6 0.25 11.2 5.6 1.2 1 0 0 1 1 1 0 Rifin GREB1 PF15782.5 CDF36413.1 - 0.23 8.6 10.9 0.29 8.2 10.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3987 PF13148.6 CDF36413.1 - 1.4 7.8 13.2 2.4 7.1 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RR_TM4-6 PF06459.12 CDF36413.1 - 8.9 6.0 18.6 15 5.3 18.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ERCC4 PF02732.15 CDF36414.1 - 5.6e-13 49.4 0.0 1.1e-12 48.5 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 CDF36414.1 - 0.0012 19.2 0.0 0.012 16.0 0.0 2.6 3 0 0 3 3 3 1 Helix-hairpin-helix domain TetR_C_25 PF17933.1 CDF36414.1 - 0.014 15.7 0.4 0.2 12.0 0.1 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Barttin PF15462.6 CDF36414.1 - 0.026 14.3 3.6 0.06 13.1 3.6 1.5 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) DUF4364 PF14277.6 CDF36414.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) RT_RNaseH PF17917.1 CDF36417.1 - 1.4e-34 118.5 0.1 1.7e-33 115.0 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF36417.1 - 2.6e-32 110.8 0.0 4.4e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF36417.1 - 5.8e-17 62.0 0.1 1.8e-16 60.4 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF36417.1 - 2.1e-12 46.9 0.0 4.9e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF36417.1 - 1.1e-05 25.3 0.0 2.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF36417.1 - 0.0023 17.7 0.1 0.024 14.4 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDF36417.1 - 0.013 15.7 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger Mtf2_C PF14061.6 CDF36417.1 - 0.016 15.3 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 UQ_con PF00179.26 CDF36418.1 - 1.1e-36 125.6 0.1 1.9e-36 124.8 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RT_RNaseH PF17917.1 CDF36419.1 - 3e-33 114.2 0.3 1.4e-31 108.8 0.0 2.8 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF36419.1 - 7.1e-31 106.2 0.0 1.8e-30 104.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF36419.1 - 3.2e-12 46.4 0.0 5.1e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF36419.1 - 1.4e-09 38.2 0.0 3e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CDF36419.1 - 3.4e-07 30.0 0.0 5.8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF36419.1 - 0.00015 21.9 0.1 0.00028 21.0 0.1 1.4 1 0 0 1 1 1 1 H2C2 zinc finger PIF1 PF05970.14 CDF36420.1 - 1e-90 304.6 0.0 1.5e-90 304.0 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF36420.1 - 3.7e-31 108.8 0.2 3.7e-31 108.8 0.2 1.8 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF36420.1 - 3.6e-05 23.6 0.0 6.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_UL16 PF03044.14 CDF36420.1 - 0.084 12.2 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus UL16/UL94 family RT_RNaseH PF17917.1 CDF36421.1 - 1.7e-36 124.7 0.2 3.1e-34 117.4 0.0 3.2 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF36421.1 - 1.6e-33 114.7 0.0 7.2e-33 112.6 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF36421.1 - 1.9e-19 70.0 0.0 3.7e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF36421.1 - 7.9e-13 48.3 0.1 1.5e-12 47.5 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF36421.1 - 2e-06 27.6 3.9 4.3e-06 26.5 0.7 2.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CDF36421.1 - 0.007 15.9 0.3 0.1 12.1 0.0 2.2 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF36421.1 - 0.013 15.7 0.1 0.026 14.8 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger rve_3 PF13683.6 CDF36421.1 - 0.018 14.8 0.0 0.054 13.3 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain Glycolytic PF00274.19 CDF36423.1 - 1.1e-12 47.4 0.0 1.2e-12 47.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Enolase_C PF00113.22 CDF36425.1 - 3.7e-150 499.1 0.1 3.7e-150 499.1 0.1 1.5 2 0 0 2 2 2 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CDF36425.1 - 4.2e-55 185.5 0.4 1.1e-54 184.1 0.4 1.7 2 0 0 2 2 2 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CDF36425.1 - 5.3e-09 36.0 0.0 8.2e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDF36425.1 - 8.8e-06 25.0 0.1 1.7e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Ras PF00071.22 CDF36426.1 - 4.6e-64 214.9 0.7 5.5e-64 214.6 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF36426.1 - 8.1e-36 122.9 0.1 1.5e-35 122.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF36426.1 - 2.4e-16 59.7 0.1 2.9e-16 59.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDF36426.1 - 4.7e-05 23.4 0.1 0.00026 21.1 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF36426.1 - 5e-05 23.3 0.4 0.12 12.2 0.0 2.4 1 1 2 3 3 3 2 RsgA GTPase SRPRB PF09439.10 CDF36426.1 - 9.9e-05 21.8 0.1 0.00013 21.5 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDF36426.1 - 0.00019 20.9 0.1 0.00023 20.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDF36426.1 - 0.00039 20.0 0.3 0.0006 19.4 0.3 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.29 CDF36426.1 - 0.00045 20.6 0.2 0.12 12.8 0.0 2.3 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDF36426.1 - 0.022 14.3 0.0 0.35 10.4 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region LANC_like PF05147.13 CDF36426.1 - 0.023 13.3 0.1 0.057 12.0 0.0 1.6 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein CENP-M PF11111.8 CDF36426.1 - 0.029 13.6 0.1 0.043 13.0 0.1 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_29 PF13555.6 CDF36426.1 - 0.057 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF36426.1 - 0.077 13.4 0.0 0.13 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 CDF36426.1 - 0.1 12.2 0.0 0.81 9.2 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 CDF36426.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain Skp1 PF01466.19 CDF36427.1 - 5.2e-26 90.5 0.2 1.2e-25 89.3 0.2 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CDF36427.1 - 5.2e-19 68.2 0.4 1.2e-18 67.1 0.2 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 CDF36427.1 - 0.061 13.5 0.1 0.16 12.2 0.1 1.6 1 1 0 1 1 1 0 BTB/POZ domain GCV_T PF01571.21 CDF36430.1 - 1.6e-85 286.6 0.0 2e-85 286.3 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CDF36430.1 - 1.9e-18 66.1 0.1 4.9e-18 64.8 0.1 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Lipase_GDSL_2 PF13472.6 CDF36431.1 - 2.9e-09 37.6 0.1 1.1e-08 35.7 0.0 2.0 3 0 0 3 3 3 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDF36431.1 - 3.3e-05 23.9 0.0 0.00011 22.3 0.0 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Ail_Lom PF06316.11 CDF36431.1 - 0.032 13.9 0.4 0.032 13.9 0.4 2.0 2 0 0 2 2 2 0 Enterobacterial Ail/Lom protein Band_7_C PF16200.5 CDF36431.1 - 4.1 7.5 9.6 0.9 9.6 1.0 2.5 1 1 1 2 2 2 0 C-terminal region of band_7 Mito_carr PF00153.27 CDF36433.1 - 1e-64 214.4 0.3 7.2e-22 77.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Amidohydro_1 PF01979.20 CDF36435.1 - 1.7e-54 185.5 0.1 2.2e-54 185.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDF36435.1 - 2.2e-11 43.9 0.3 7e-08 32.4 0.1 2.4 2 1 0 2 2 2 2 Amidohydrolase family Aldo_ket_red PF00248.21 CDF36435.1 - 0.017 14.4 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Aldo/keto reductase family DUF525 PF04379.14 CDF36436.1 - 5.3e-31 106.7 0.1 7.7e-31 106.2 0.1 1.3 1 0 0 1 1 1 1 ApaG domain UVR PF02151.19 CDF36436.1 - 2.4e-10 39.8 12.2 1.4e-05 24.6 4.0 2.2 2 0 0 2 2 2 2 UvrB/uvrC motif DUF3611 PF12263.8 CDF36437.1 - 4.8e-37 127.6 14.2 7.2e-37 127.0 14.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3611) DUF973 PF06157.11 CDF36437.1 - 2.2 7.2 8.2 5.5 5.9 8.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF973) DUF1700 PF08006.11 CDF36437.1 - 2.3 7.7 7.7 0.73 9.4 4.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) FKBP_C PF00254.28 CDF36438.1 - 1.3e-44 150.4 0.1 2.3e-28 98.4 0.0 3.7 3 0 0 3 3 3 3 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 CDF36438.1 - 5.4e-18 64.0 5.7 6.3e-07 28.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDF36438.1 - 3e-14 51.9 2.7 4.1e-05 23.4 1.8 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDF36438.1 - 6.7e-11 41.5 3.2 0.00023 21.1 1.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_N_2 PF18023.1 CDF36438.1 - 7.8e-08 32.4 0.0 0.00035 20.7 0.0 4.0 3 1 0 3 3 3 1 BDBT FKBP like N-terminal TPR_11 PF13414.6 CDF36438.1 - 1.5e-06 27.8 6.8 0.054 13.2 1.4 3.5 2 1 1 3 3 3 3 TPR repeat TPR_19 PF14559.6 CDF36438.1 - 3e-05 24.4 2.5 0.00096 19.6 1.8 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDF36438.1 - 3.3e-05 24.1 0.0 0.15 12.4 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF36438.1 - 3.5e-05 23.9 3.0 0.011 16.1 0.7 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36438.1 - 0.00023 21.7 1.3 0.35 11.5 0.0 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF36438.1 - 0.00044 20.8 0.0 14 6.8 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 CDF36438.1 - 0.0019 18.7 0.0 0.0038 17.7 0.0 1.5 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 CDF36438.1 - 0.0019 18.1 0.7 15 5.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF36438.1 - 0.0051 17.4 1.4 0.43 11.3 0.5 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF36438.1 - 0.0064 16.5 7.5 0.33 11.0 2.4 3.3 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat HSM3_N PF18795.1 CDF36438.1 - 0.014 14.9 0.1 0.025 14.0 0.1 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain Synaptobrevin PF00957.21 CDF36439.1 - 6.9e-17 61.0 2.0 6.9e-17 61.0 2.0 1.8 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 CDF36439.1 - 7.7e-17 61.1 0.0 1.7e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Regulated-SNARE-like domain YgaB PF14182.6 CDF36439.1 - 0.066 13.6 0.5 0.39 11.1 0.3 2.2 2 0 0 2 2 2 0 YgaB-like protein Spc7 PF08317.11 CDF36439.1 - 0.54 9.1 5.1 0.3 9.9 2.9 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein EMP24_GP25L PF01105.24 CDF36439.1 - 1.7 8.5 6.0 19 5.1 3.5 2.9 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4407 PF14362.6 CDF36439.1 - 3 7.1 9.4 0.87 8.9 2.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) GFO_IDH_MocA PF01408.22 CDF36440.1 - 1.7e-23 83.7 0.1 3.3e-23 82.8 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDF36440.1 - 3.4e-12 46.4 0.0 7.2e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Gp_dh_N PF00044.24 CDF36440.1 - 0.0012 19.2 0.3 0.0034 17.7 0.2 1.8 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDF36440.1 - 0.0012 18.2 0.1 0.002 17.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CDF36440.1 - 0.0014 19.2 1.0 0.0039 17.7 0.4 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 CDF36440.1 - 0.013 15.6 0.3 0.036 14.2 0.3 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Rossmann-like PF10727.9 CDF36440.1 - 0.018 14.9 0.1 0.042 13.7 0.1 1.6 1 0 0 1 1 1 0 Rossmann-like domain Sacchrp_dh_NADP PF03435.18 CDF36440.1 - 0.047 13.9 0.4 0.16 12.2 0.3 2.0 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CDF36440.1 - 0.083 12.9 0.0 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CDF36440.1 - 0.13 11.6 0.2 0.25 10.7 0.2 1.4 1 0 0 1 1 1 0 ThiF family TPR_7 PF13176.6 CDF36441.1 - 4.1e-07 29.6 11.1 0.64 10.2 0.1 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDF36441.1 - 4.5e-07 29.5 17.7 0.055 13.6 0.1 7.7 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF36441.1 - 1.6e-05 25.3 16.2 0.23 12.0 0.7 6.3 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CDF36441.1 - 1.8e-05 24.3 4.1 0.00035 20.1 0.5 3.3 3 0 0 3 3 3 1 MalT-like TPR region TPR_1 PF00515.28 CDF36441.1 - 2.5e-05 23.9 5.5 0.13 12.1 0.2 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF36441.1 - 3.2e-05 24.1 15.1 0.0057 16.9 0.5 5.5 4 1 1 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 CDF36441.1 - 0.00033 21.0 28.9 0.42 11.4 0.1 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF36441.1 - 0.0015 18.8 19.1 0.041 14.2 0.1 5.9 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF36441.1 - 0.0042 17.2 10.4 11 6.5 0.1 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TOH_N PF12549.8 CDF36441.1 - 0.011 15.6 0.1 0.092 12.6 0.0 2.5 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal TPR_20 PF14561.6 CDF36441.1 - 0.012 15.9 8.0 0.26 11.6 0.1 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDF36441.1 - 0.035 14.5 3.4 2.2 8.8 0.1 4.5 5 0 0 5 5 3 0 Tetratricopeptide repeat Ntox4 PF15541.6 CDF36441.1 - 0.14 12.5 0.1 0.54 10.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial toxin 4 UPF0253 PF06786.12 CDF36441.1 - 0.24 11.7 2.5 0.43 10.9 0.6 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0253) TPR_16 PF13432.6 CDF36441.1 - 0.25 12.0 25.5 0.49 11.1 0.1 7.1 8 0 0 8 8 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF36441.1 - 0.43 10.7 3.3 1.3 9.2 0.3 2.8 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 CDF36441.1 - 3 8.9 20.9 1.1 10.3 0.2 6.7 6 2 1 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF36441.1 - 4.3 8.2 16.0 3.6 8.4 0.3 6.5 8 0 0 8 8 6 0 Tetratricopeptide repeat Peptidase_M16_C PF05193.21 CDF36442.1 - 1.3e-10 41.6 0.0 2.5e-06 27.6 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDF36442.1 - 1.8e-07 31.2 0.1 2.1e-06 27.8 0.0 2.5 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) UQ_con PF00179.26 CDF36443.1 - 5.8e-54 181.5 0.0 6.5e-54 181.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF36443.1 - 0.00027 20.6 0.0 0.00032 20.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDF36443.1 - 0.0018 18.5 0.0 0.0022 18.3 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 CDF36443.1 - 0.036 13.9 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain G-gamma PF00631.22 CDF36443.1 - 0.12 12.3 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 GGL domain zf-CCCH PF00642.24 CDF36444.1 - 2.7e-09 36.7 2.4 2.7e-09 36.7 2.4 1.8 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 CDF36444.1 - 5.4e-08 32.6 6.5 9.8e-08 31.7 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF36444.1 - 4.9e-07 29.7 5.1 6.3e-07 29.3 2.9 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDF36444.1 - 8e-07 28.8 8.6 8e-07 28.8 8.6 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF36444.1 - 4.9e-06 26.4 9.6 8.8e-06 25.6 9.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf_CCCH_4 PF18345.1 CDF36444.1 - 4.9e-06 26.4 4.5 1.1e-05 25.3 4.5 1.7 1 0 0 1 1 1 1 Zinc finger domain Prok-RING_4 PF14447.6 CDF36444.1 - 5.7e-05 22.9 6.8 0.00011 22.0 6.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CDF36444.1 - 8.4e-05 22.8 9.0 8.4e-05 22.8 9.0 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 CDF36444.1 - 0.00011 22.0 9.4 0.00023 21.0 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 CDF36444.1 - 0.00022 20.9 2.7 0.00022 20.9 2.7 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger zf-P11 PF03854.14 CDF36444.1 - 0.0028 17.3 5.2 0.0055 16.3 5.2 1.5 1 0 0 1 1 1 1 P-11 zinc finger zf-C3HC4_4 PF15227.6 CDF36444.1 - 0.005 17.0 4.7 0.005 17.0 4.7 2.0 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.6 CDF36444.1 - 0.022 15.2 1.9 0.054 14.0 1.9 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-RING_10 PF16685.5 CDF36444.1 - 0.023 14.8 4.8 0.023 14.8 4.8 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 Gin PF10764.9 CDF36444.1 - 1.6 8.7 7.1 11 6.0 3.8 2.6 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin zf-rbx1 PF12678.7 CDF36444.1 - 2 8.8 8.4 13 6.2 8.6 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain UQ_con PF00179.26 CDF36445.1 - 6.8e-48 161.9 0.0 7.7e-48 161.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF36445.1 - 0.043 13.5 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 CDF36445.1 - 0.17 12.2 0.2 0.23 11.7 0.2 1.4 1 1 0 1 1 1 0 RWD domain LETM1 PF07766.13 CDF36446.1 - 5.1e-40 137.5 0.2 8.3e-40 136.8 0.2 1.3 1 0 0 1 1 1 1 LETM1-like protein LETM1 PF07766.13 CDF36448.1 - 1.9e-13 50.4 0.2 1.9e-13 50.4 0.2 2.1 3 0 0 3 3 3 1 LETM1-like protein EF-hand_1 PF00036.32 CDF36448.1 - 1.1e-06 27.7 0.3 0.0042 16.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDF36448.1 - 9.5e-05 22.0 0.3 0.17 11.9 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDF36448.1 - 0.0032 16.9 2.4 0.3 10.6 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 CDF36448.1 - 0.02 15.3 11.5 0.11 13.0 0.7 3.4 4 1 0 4 4 4 0 EF-hand domain pair Plasmid_RAQPRD PF09686.10 CDF36448.1 - 0.12 12.6 0.4 0.12 12.6 0.4 2.3 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) PfkB PF00294.24 CDF36449.1 - 0.052 12.9 0.2 0.052 12.9 0.2 1.4 2 0 0 2 2 2 0 pfkB family carbohydrate kinase TP6A_N PF04406.14 CDF36452.1 - 2.8e-13 49.6 0.2 6.2e-13 48.5 0.2 1.6 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DDE_3 PF13358.6 CDF36453.1 - 2.6e-14 53.2 0.0 3.7e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase PF00069.25 CDF36457.1 - 3.5e-45 154.4 0.0 3.7e-32 111.7 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36457.1 - 5.5e-27 94.7 0.0 4.7e-21 75.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDF36457.1 - 1.5e-07 31.0 0.0 0.0027 17.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CDF36457.1 - 0.00027 19.9 0.0 0.00051 18.9 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase RNA_pol_3_Rpc31 PF11705.8 CDF36457.1 - 0.00055 20.2 15.8 0.0011 19.3 15.8 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.12 CDF36457.1 - 0.003 17.0 12.1 0.0039 16.7 12.1 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 CDF36457.1 - 0.012 13.8 16.0 0.016 13.5 16.0 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 CDF36457.1 - 0.016 14.5 11.8 0.022 14.1 11.8 1.1 1 0 0 1 1 1 0 BUD22 Hox9_act PF04617.13 CDF36457.1 - 0.023 15.5 3.2 0.036 14.8 3.2 1.3 1 0 0 1 1 1 0 Hox9 activation region APH PF01636.23 CDF36457.1 - 0.027 14.4 0.1 1.2 9.0 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CDF36457.1 - 0.048 12.7 0.0 0.074 12.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Mpp10 PF04006.12 CDF36457.1 - 0.051 12.0 15.4 0.067 11.6 15.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Cwf_Cwc_15 PF04889.12 CDF36457.1 - 0.084 12.6 14.5 0.11 12.2 14.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 CDF36457.1 - 0.14 10.4 14.9 0.21 9.8 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PIP49_C PF12260.8 CDF36457.1 - 0.29 10.8 0.8 1.4 8.5 0.4 2.3 2 1 0 2 2 2 0 Protein-kinase domain of FAM69 RAB3GAP2_C PF14656.6 CDF36457.1 - 0.3 9.2 1.7 0.43 8.8 1.7 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus TFB6 PF17110.5 CDF36457.1 - 0.41 10.4 5.8 0.64 9.7 5.8 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SAPS PF04499.15 CDF36457.1 - 0.41 9.4 3.4 0.64 8.7 3.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CDF36457.1 - 0.42 9.3 1.8 0.54 9.0 1.8 1.1 1 0 0 1 1 1 0 Presenilin RXT2_N PF08595.11 CDF36457.1 - 0.59 10.1 9.9 1.2 9.2 9.9 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2722 PF10846.8 CDF36457.1 - 0.69 8.8 6.6 0.9 8.4 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDF36457.1 - 0.81 9.6 11.6 1 9.3 11.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Vfa1 PF08432.10 CDF36457.1 - 0.91 9.8 13.4 1.6 9.0 13.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 CDF36457.1 - 1.3 8.0 2.8 1.8 7.4 2.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 CDF36457.1 - 1.3 8.2 2.9 1.8 7.7 2.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Roughex PF06020.11 CDF36457.1 - 1.3 8.0 11.9 1.9 7.5 11.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein RNA_pol_Rpc4 PF05132.14 CDF36457.1 - 1.3 9.4 11.2 4.5 7.7 8.3 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 CDF36457.1 - 1.3 8.7 9.7 1.9 8.2 9.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cytomega_UL84 PF06284.11 CDF36457.1 - 1.5 7.1 12.3 3.1 6.1 12.3 1.5 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein NPR3 PF03666.13 CDF36457.1 - 1.6 7.4 4.6 2.3 6.9 4.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CPSF100_C PF13299.6 CDF36457.1 - 3 8.0 7.8 5.9 7.0 7.8 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Afi1 PF07792.12 CDF36457.1 - 3 8.3 9.8 5.3 7.5 9.8 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TFIIF_alpha PF05793.12 CDF36457.1 - 4.8 5.6 23.3 6.9 5.1 23.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNA_polI_A34 PF08208.11 CDF36457.1 - 6.2 6.9 17.0 9.2 6.3 17.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3464 PF11947.8 CDF36457.1 - 8.3 6.1 5.5 16 5.3 5.5 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2457 PF10446.9 CDF36457.1 - 8.9 5.3 28.8 40 3.2 29.8 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 CDF36457.1 - 9.2 5.5 18.9 17 4.6 18.9 1.4 1 0 0 1 1 1 0 NOA36 protein Pkinase PF00069.25 CDF36458.1 - 1.8e-47 161.9 0.0 1.4e-46 159.0 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36458.1 - 2.4e-27 95.9 0.0 5.8e-20 71.7 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF36458.1 - 2.4e-05 23.3 0.0 0.00016 20.6 0.0 1.9 1 1 1 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CDF36458.1 - 2.7e-05 23.7 0.0 0.0031 16.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Mcp5_PH PF12814.7 CDF36458.1 - 0.12 12.4 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Bac_globin PF01152.21 CDF36459.1 - 6.7e-22 77.9 0.0 8.3e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial-like globin Cofilin_ADF PF00241.20 CDF36460.1 - 6.3e-31 106.7 0.2 7.1e-31 106.5 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Pkinase PF00069.25 CDF36461.1 - 6.6e-75 251.9 0.0 9.3e-75 251.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36461.1 - 1.3e-39 136.0 0.0 2.2e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF36461.1 - 5.2e-05 22.7 0.0 8.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF36461.1 - 0.00051 19.5 0.1 0.00095 18.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF36461.1 - 0.0039 17.1 0.0 0.015 15.3 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF36461.1 - 0.0053 16.4 0.2 0.016 14.8 0.0 1.8 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 CDF36461.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Msg2_C PF12373.8 CDF36461.1 - 0.065 12.7 0.3 0.15 11.5 0.3 1.6 1 0 0 1 1 1 0 Major surface glycoprotein 2 C terminal Ephrin_rec_like PF07699.13 CDF36464.1 - 3.6e-15 55.4 37.6 4.1e-08 32.9 10.0 14.0 6 4 10 16 16 16 11 Putative ephrin-receptor like TMEM18 PF14770.6 CDF36465.1 - 5.3e-29 100.6 3.1 6.6e-29 100.3 3.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 DUF983 PF06170.12 CDF36465.1 - 0.56 10.6 6.0 3.9 8.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Wzy_C PF04932.15 CDF36465.1 - 1.3 8.6 5.0 2.6 7.7 5.0 1.5 1 1 0 1 1 1 0 O-Antigen ligase TIM PF00121.18 CDF36466.1 - 1.4e-84 283.2 0.0 1.6e-84 283.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase UCH PF00443.29 CDF36467.1 - 3.6e-15 56.2 0.0 8.6e-15 54.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF36467.1 - 3.7e-06 26.8 0.0 3.9e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF383 PF04063.14 CDF36467.1 - 0.031 14.0 0.0 0.24 11.1 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF383) RINGv PF12906.7 CDF36468.1 - 1.1e-14 54.2 6.2 1.9e-14 53.5 6.2 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CDF36468.1 - 0.0052 17.1 6.4 0.0098 16.2 6.4 1.5 1 0 0 1 1 1 1 Ring finger domain HA PF03457.14 CDF36469.1 - 1.2e-51 172.9 14.3 2.4e-18 66.2 0.6 3.3 3 0 0 3 3 3 3 Helicase associated domain DnaJ_C PF01556.18 CDF36470.1 - 3.2e-39 134.4 0.0 4.9e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDF36470.1 - 1.3e-27 95.7 3.4 2.2e-27 94.9 3.4 1.4 1 0 0 1 1 1 1 DnaJ domain IMS PF00817.20 CDF36471.1 - 1.5e-29 103.0 0.0 5e-29 101.2 0.0 1.8 1 1 0 1 1 1 1 impB/mucB/samB family RNF220 PF15926.5 CDF36471.1 - 0.0005 19.8 0.0 0.00085 19.0 0.0 1.3 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 IMS_C PF11799.8 CDF36471.1 - 0.0034 18.1 0.4 0.0073 17.0 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain DUF5539 PF17693.1 CDF36472.1 - 0.34 10.5 6.3 0.35 10.5 6.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5539) WD40 PF00400.32 CDF36473.1 - 4.6e-07 30.4 4.5 0.18 12.7 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Sec16_C PF12931.7 CDF36473.1 - 6.2e-07 29.4 0.9 5.1e-06 26.4 0.1 2.7 2 1 0 2 2 2 1 Sec23-binding domain of Sec16 ANAPC4_WD40 PF12894.7 CDF36473.1 - 9.3e-05 22.7 0.6 0.15 12.4 0.3 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SRA1 PF07304.11 CDF36473.1 - 0.00016 21.5 0.0 0.00016 21.5 0.0 2.2 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) RRF PF01765.19 CDF36474.1 - 8.3e-59 198.2 0.7 1.1e-58 197.8 0.7 1.1 1 0 0 1 1 1 1 Ribosome recycling factor 14-3-3 PF00244.20 CDF36474.1 - 0.055 13.0 2.6 0.091 12.3 2.6 1.2 1 0 0 1 1 1 0 14-3-3 protein YtxH PF12732.7 CDF36474.1 - 0.4 11.3 7.1 9.5 6.8 0.2 2.5 1 1 1 2 2 2 0 YtxH-like protein Romo1 PF10247.9 CDF36475.1 - 2.4e-14 53.4 5.6 3.4e-14 52.9 5.6 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 zf-C3HC4_3 PF13920.6 CDF36477.1 - 4.7e-06 26.4 7.0 4.7e-06 26.4 7.0 4.4 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF36477.1 - 0.0017 18.2 6.6 0.0017 18.2 6.6 3.7 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 ArfGap PF01412.18 CDF36477.1 - 0.17 11.9 5.0 0.51 10.4 5.0 1.8 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf GDC-P PF02347.16 CDF36479.1 - 3.1e-181 602.9 0.1 1e-169 564.9 0.1 3.2 3 0 0 3 3 3 3 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 CDF36479.1 - 1.1e-05 24.9 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase ELFV_dehydrog_N PF02812.18 CDF36480.1 - 5.8e-55 184.7 0.0 1.1e-54 183.8 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 CDF36480.1 - 2.6e-51 174.7 0.0 3.4e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ribosomal_S30 PF04758.14 CDF36481.1 - 2.9e-27 94.6 6.3 4.1e-27 94.2 6.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S30 MOZ_SAS PF01853.18 CDF36482.1 - 1.5e-64 217.0 0.0 2.4e-64 216.3 0.0 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CDF36482.1 - 2e-20 72.1 3.0 5.6e-20 70.7 2.7 1.9 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDF36482.1 - 0.00014 21.7 0.0 0.00028 20.7 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CDF36482.1 - 0.026 14.9 0.0 0.053 14.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain S4 PF01479.25 CDF36483.1 - 5.7e-12 45.1 0.0 9.6e-12 44.4 0.0 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CDF36483.1 - 2.3e-07 30.5 0.0 4.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 CDF36483.1 - 4.9e-07 30.6 1.1 9.8e-07 29.6 1.1 1.7 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Fe-S_biosyn PF01521.20 CDF36485.1 - 2.9e-13 50.0 0.0 3.8e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3263 PF11662.8 CDF36485.1 - 0.012 15.4 1.0 0.022 14.6 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) ACOX PF01756.19 CDF36487.1 - 9e-15 54.7 0.2 1.5e-14 54.0 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 CDF36487.1 - 1.1e-11 44.7 0.0 2.1e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 CDF36487.1 - 8.6e-07 29.6 0.3 1.9e-06 28.4 0.0 1.8 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 CDF36487.1 - 0.00056 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDF36487.1 - 0.011 16.4 0.0 0.036 14.7 0.0 1.9 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Glyco_hydro_18 PF00704.28 CDF36488.1 - 2.1e-16 60.6 0.0 2.9e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF2705 PF10920.8 CDF36488.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2705) NAPRTase_N PF17767.1 CDF36489.1 - 2.1e-35 121.8 0.0 4.1e-35 120.9 0.0 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 CDF36489.1 - 1.2e-05 25.6 0.0 2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 CDF36489.1 - 2e-05 24.3 0.0 0.0006 19.5 0.0 2.1 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family QRPTase_N PF02749.16 CDF36489.1 - 0.0016 18.5 0.0 0.0063 16.6 0.0 2.0 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain Brix PF04427.18 CDF36490.1 - 9.7e-35 120.4 0.1 1.2e-34 120.1 0.1 1.1 1 0 0 1 1 1 1 Brix domain Rho_RNA_bind PF07497.12 CDF36490.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Rho termination factor, RNA-binding domain Aminotran_1_2 PF00155.21 CDF36491.1 - 1.2e-32 113.5 0.0 1.4e-32 113.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CDF36491.1 - 1.9e-09 36.9 0.0 3.4e-09 36.0 0.0 1.3 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Aminotran_5 PF00266.19 CDF36491.1 - 0.13 11.2 0.0 0.23 10.4 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V Pyr_redox_2 PF07992.14 CDF36494.1 - 1.4e-11 44.2 0.1 2.2e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF36494.1 - 0.00065 20.2 0.1 0.015 15.8 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Bmt2 PF11968.8 CDF36496.1 - 9.6e-43 146.6 0.2 5.7e-42 144.1 0.2 2.1 1 1 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_25 PF13649.6 CDF36496.1 - 0.00077 20.1 0.1 0.13 13.0 0.0 2.9 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF36496.1 - 0.0015 18.4 0.0 0.0038 17.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF36496.1 - 0.12 13.1 0.0 1 10.0 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain PX PF00787.24 CDF36498.1 - 6.7e-14 51.8 0.0 2.1e-12 47.0 0.0 2.5 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 CDF36498.1 - 0.083 12.4 2.1 0.86 9.1 0.2 2.3 2 0 0 2 2 2 0 Vps5 C terminal like FlaC_arch PF05377.11 CDF36498.1 - 0.13 12.6 0.2 6.8 7.2 0.1 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) NOG1_N PF17835.1 CDF36498.1 - 0.29 11.1 3.9 3.8 7.5 0.1 3.1 3 0 0 3 3 3 0 NOG1 N-terminal helical domain DUF3110 PF11360.8 CDF36500.1 - 4.4e-07 30.0 0.0 7e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3110) EamA PF00892.20 CDF36502.1 - 3.9e-26 91.9 31.6 9.2e-15 55.0 13.8 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CDF36502.1 - 0.00021 20.7 7.3 0.00059 19.3 2.1 2.4 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 CDF36503.1 - 2.1e-13 50.6 31.4 6.4e-08 32.9 7.7 2.2 2 0 0 2 2 2 2 EamA-like transporter family HKR_ArcB_TM PF18415.1 CDF36503.1 - 5.8 7.8 9.1 0.23 12.3 1.0 2.7 2 1 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain Zeta_toxin PF06414.12 CDF36504.1 - 1.3e-17 63.7 0.0 4.4e-15 55.5 0.0 2.2 2 0 0 2 2 2 2 Zeta toxin Thioredoxin PF00085.20 CDF36504.1 - 1.8e-09 37.5 0.0 4.5e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin AAA_16 PF13191.6 CDF36504.1 - 0.014 15.8 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Thioredoxin_7 PF13899.6 CDF36504.1 - 0.084 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like AAA_30 PF13604.6 CDF36504.1 - 0.085 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Surp PF01805.20 CDF36505.1 - 1.2e-26 92.4 0.3 8.2e-16 57.7 0.1 2.7 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 CDF36505.1 - 9.3e-20 71.4 3.3 9.3e-20 71.4 3.3 2.6 3 0 0 3 3 3 1 Pre-mRNA splicing factor PRP21 like protein ubiquitin PF00240.23 CDF36505.1 - 1.2e-08 34.6 0.3 2.9e-08 33.3 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin family DDE_1 PF03184.19 CDF36506.1 - 0.023 14.3 0.0 0.026 14.2 0.0 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease PSD3 PF07626.11 CDF36509.1 - 0.1 13.1 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) Nt_Gln_amidase PF09764.9 CDF36510.1 - 4.7e-37 127.4 0.0 5.7e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 N-terminal glutamine amidase Gln_deamidase_2 PF18626.1 CDF36510.1 - 0.078 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Glutaminase Patatin PF01734.22 CDF36512.1 - 3.6e-20 73.0 1.9 1.5e-19 71.0 1.9 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase KH_8 PF17903.1 CDF36513.1 - 1.1e-30 105.5 0.0 2.9e-30 104.2 0.0 1.8 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 CDF36513.1 - 0.00065 19.5 0.0 0.002 17.9 0.0 1.8 1 0 0 1 1 1 1 KH domain zf-HC5HC2H PF13771.6 CDF36514.1 - 6.7e-10 39.1 12.7 3.4e-06 27.2 5.5 3.2 3 0 0 3 3 3 2 PHD-like zinc-binding domain BRCT_2 PF16589.5 CDF36514.1 - 7.5e-07 29.5 0.0 0.00031 21.1 0.0 2.3 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain PHD PF00628.29 CDF36514.1 - 1.6e-06 27.9 4.6 1.6e-06 27.9 4.6 3.5 4 0 0 4 4 4 2 PHD-finger zf-HC5HC2H_2 PF13832.6 CDF36514.1 - 2.7e-05 24.3 14.6 0.0047 17.1 4.1 3.0 2 1 1 3 3 3 2 PHD-zinc-finger like domain PHD_2 PF13831.6 CDF36514.1 - 0.0003 20.3 7.3 0.0064 16.0 2.3 3.7 3 0 0 3 3 3 1 PHD-finger BRCT PF00533.26 CDF36514.1 - 0.00042 20.7 0.0 0.14 12.6 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain OTU PF02338.19 CDF36515.1 - 3.8e-17 63.0 0.1 3.8e-17 63.0 0.1 1.9 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CDF36515.1 - 7.5e-07 28.8 3.6 0.0053 16.2 0.3 2.6 1 1 1 2 2 2 2 Peptidase C65 Otubain Med19 PF10278.9 CDF36515.1 - 7 6.6 12.0 13 5.7 12.0 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TFA2_Winged_2 PF18121.1 CDF36517.1 - 2e-05 24.2 0.1 6.4e-05 22.6 0.1 2.0 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 HA2 PF04408.23 CDF36518.1 - 7.2e-20 71.3 0.0 2.7e-19 69.4 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDF36518.1 - 3.2e-13 49.9 0.0 7.1e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDF36518.1 - 3.2e-13 50.0 0.0 7.5e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDF36518.1 - 6.7e-06 26.4 0.2 3.1e-05 24.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 CDF36518.1 - 1.4e-05 24.9 0.0 3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CDF36518.1 - 0.0008 19.2 0.1 0.0075 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDF36518.1 - 0.0055 15.8 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.14 CDF36518.1 - 0.0099 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_14 PF13173.6 CDF36518.1 - 0.017 15.1 0.1 0.083 12.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CDF36518.1 - 0.037 13.3 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CDF36518.1 - 0.042 14.2 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CDF36518.1 - 0.043 13.8 0.0 8.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.16 CDF36518.1 - 0.072 12.5 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 CDF36518.1 - 0.081 13.3 0.1 0.32 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 CDF36518.1 - 0.097 12.2 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDF36518.1 - 0.11 12.2 0.0 7.1 6.3 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_tran PF00005.27 CDF36518.1 - 0.11 13.0 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 CDF36518.1 - 0.15 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CDF36518.1 - 0.16 11.6 0.1 0.32 10.6 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDF36518.1 - 0.28 11.3 2.8 0.28 11.3 0.1 2.5 2 1 0 2 2 2 0 AAA domain TIP120 PF08623.10 CDF36519.1 - 2e-37 128.6 0.0 1.3e-34 119.4 0.0 4.0 3 1 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 CDF36519.1 - 1.7e-12 47.5 26.1 0.025 15.0 0.2 10.3 9 3 3 12 12 11 4 HEAT repeats HEAT PF02985.22 CDF36519.1 - 5.4e-11 41.8 36.9 0.15 12.4 0.3 12.1 14 0 0 14 14 13 5 HEAT repeat Adaptin_N PF01602.20 CDF36519.1 - 0.00081 18.1 9.1 0.64 8.5 0.9 4.5 5 0 0 5 5 5 3 Adaptin N terminal region V-ATPase_H_C PF11698.8 CDF36519.1 - 0.0021 18.2 0.4 33 4.6 0.0 5.0 4 0 0 4 4 4 0 V-ATPase subunit H HEAT_EZ PF13513.6 CDF36519.1 - 0.0037 17.7 23.9 11 6.7 0.1 11.5 12 2 2 14 14 14 1 HEAT-like repeat CLASP_N PF12348.8 CDF36519.1 - 0.021 14.4 1.7 2.7 7.5 0.0 4.3 4 1 1 5 5 5 0 CLASP N terminal MMS19_N PF14500.6 CDF36519.1 - 0.037 13.6 5.0 0.8 9.2 0.0 4.7 4 2 1 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II ParcG PF10274.9 CDF36519.1 - 0.12 12.5 0.1 24 5.0 0.1 3.6 3 1 1 4 4 4 0 Parkin co-regulated protein NOA36 PF06524.12 CDF36519.1 - 1.7 7.9 6.6 3.1 7.0 6.6 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CDF36519.1 - 7.5 4.5 14.4 19 3.1 12.2 2.6 3 0 0 3 3 3 0 DNA polymerase phi CLTH PF10607.9 CDF36520.1 - 3.8e-28 98.2 0.0 6.2e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain mRNA_cap_C PF03919.15 CDF36521.1 - 1.5e-15 57.7 0.1 3e-15 56.8 0.1 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain mRNA_cap_enzyme PF01331.19 CDF36521.1 - 7.6e-12 45.5 0.0 1.5e-10 41.2 0.0 2.5 2 1 0 2 2 2 1 mRNA capping enzyme, catalytic domain tRNA-synt_2 PF00152.20 CDF36522.1 - 7e-95 317.7 0.0 8.3e-95 317.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDF36522.1 - 2.5e-12 46.6 0.0 4.3e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDF36522.1 - 0.14 11.6 0.0 18 4.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) rve PF00665.26 CDF36525.1 - 0.00021 21.4 0.0 0.00075 19.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Asp_protease PF09668.10 CDF36525.1 - 0.00087 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease NUDE_C PF04880.13 CDF36526.1 - 0.33 11.4 3.4 0.43 11.0 3.4 1.3 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region Endotoxin_N PF03945.14 CDF36527.1 - 7.4e-08 32.4 0.0 1.6e-07 31.2 0.0 1.5 1 1 0 1 1 1 1 delta endotoxin, N-terminal domain WD40 PF00400.32 CDF36531.1 - 5.3e-65 213.8 38.8 3e-08 34.2 0.4 9.5 9 0 0 9 9 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF36531.1 - 1.1e-19 70.5 15.0 0.1 12.9 0.1 9.1 2 1 7 9 9 9 8 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF36531.1 - 4.2e-15 55.6 0.0 8.9e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain WD40_like PF17005.5 CDF36531.1 - 1.6e-07 30.9 0.5 4.5 6.5 0.0 6.2 3 2 5 8 8 8 2 WD40-like domain Me-amine-dh_H PF06433.11 CDF36531.1 - 4.5e-07 29.1 1.9 0.52 9.1 0.0 4.2 1 1 3 4 4 4 3 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.8 CDF36531.1 - 5.3e-07 28.7 5.9 2.7 6.5 0.0 6.5 1 1 5 7 7 7 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 CDF36531.1 - 3.3e-05 23.6 32.9 0.039 13.5 11.5 3.6 1 1 3 4 4 4 4 PQQ-like domain PQQ_3 PF13570.6 CDF36531.1 - 0.00025 21.4 15.0 26 5.5 0.1 7.9 7 1 1 8 8 8 0 PQQ-like domain Phage_attach PF05354.11 CDF36531.1 - 0.04 13.8 22.4 3.1 7.7 1.7 5.5 1 1 4 6 6 6 0 Phage Head-Tail Attachment AAA_22 PF13401.6 CDF36531.1 - 0.048 13.9 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain HSP9_HSP12 PF04119.12 CDF36531.1 - 0.76 10.2 3.3 90 3.6 0.1 4.4 5 0 0 5 5 5 0 Heat shock protein 9/12 Beta-lactamase PF00144.24 CDF36533.1 - 0.092 12.0 0.2 0.13 11.5 0.2 1.2 1 0 0 1 1 1 0 Beta-lactamase APH PF01636.23 CDF36534.1 - 2.4e-07 30.9 0.0 5.6e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF36534.1 - 0.077 12.6 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase WD40 PF00400.32 CDF36538.1 - 0.00058 20.6 0.5 0.0012 19.6 0.5 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat NB-ARC PF00931.22 CDF36539.1 - 7.4e-14 51.5 0.0 1.3e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CDF36539.1 - 0.00097 19.4 0.0 0.0028 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CDF36539.1 - 0.06 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain APAF1_C PF17908.1 CDF36539.1 - 0.24 11.4 0.0 0.57 10.2 0.0 1.6 1 0 0 1 1 1 0 APAF-1 helical domain UTP25 PF06862.12 CDF36541.1 - 3e-130 435.2 0.0 6.9e-80 269.1 0.0 2.1 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF3850 PF12961.7 CDF36541.1 - 0.11 12.6 1.7 0.75 9.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3850) ECH_1 PF00378.20 CDF36543.1 - 1.3e-39 136.0 0.0 1.7e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDF36543.1 - 3.6e-19 69.5 0.0 3.9e-19 69.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CLP_protease PF00574.23 CDF36544.1 - 2.3e-52 177.6 0.0 3.7e-52 176.9 0.0 1.3 1 0 0 1 1 1 1 Clp protease UQ_con PF00179.26 CDF36546.1 - 6e-38 129.7 0.1 7.5e-38 129.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDF36546.1 - 0.16 12.3 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 RWD domain PI3_PI4_kinase PF00454.27 CDF36547.1 - 1.4e-46 159.3 0.0 2.9e-46 158.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CDF36547.1 - 4.1e-16 59.1 0.0 7.3e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 CDF36547.1 - 2.1e-11 43.4 0.2 4.8e-11 42.3 0.2 1.7 1 0 0 1 1 1 1 FATC domain UME PF08064.13 CDF36547.1 - 7.5e-10 38.6 0.1 1.7e-08 34.3 0.1 3.1 2 0 0 2 2 2 1 UME (NUC010) domain DUF3385 PF11865.8 CDF36547.1 - 0.0054 16.6 0.0 0.047 13.6 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) TPR_19 PF14559.6 CDF36547.1 - 0.16 12.5 0.0 0.16 12.5 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDF36547.1 - 0.46 10.2 2.3 1.8 8.3 2.3 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain GATA PF00320.27 CDF36548.1 - 4.3e-17 61.4 2.6 6.6e-17 60.8 2.6 1.3 1 0 0 1 1 1 1 GATA zinc finger DSHCT PF08148.12 CDF36549.1 - 0.0012 18.6 0.2 0.0085 15.8 0.0 2.4 2 0 0 2 2 2 1 DSHCT (NUC185) domain CortBP2 PF09727.9 CDF36549.1 - 3.4 7.6 12.7 4.3 7.2 4.5 2.7 2 0 0 2 2 2 0 Cortactin-binding protein-2 GvpL_GvpF PF06386.11 CDF36549.1 - 4.5 7.1 7.6 0.86 9.5 1.5 2.5 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Carb_anhydrase PF00194.21 CDF36550.1 - 4.9e-18 65.6 1.8 5.9e-17 62.1 1.8 2.3 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase rve PF00665.26 CDF36551.1 - 2.7e-10 40.5 0.1 1.2e-09 38.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF36551.1 - 4.3e-08 32.9 0.1 1.3e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain RVT_3 PF13456.6 CDF36552.1 - 0.014 15.2 0.5 0.096 12.5 0.5 2.0 1 1 0 1 1 1 0 Reverse transcriptase-like Keratin_2_head PF16208.5 CDF36553.1 - 0.05 13.8 1.2 0.075 13.2 1.2 1.3 1 0 0 1 1 1 0 Keratin type II head PIF1 PF05970.14 CDF36554.1 - 6.4e-101 338.1 0.0 9.4e-101 337.6 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF36554.1 - 2e-49 168.4 0.0 3.5e-49 167.6 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF36554.1 - 5.1e-11 42.6 0.0 9.6e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF36554.1 - 0.2 12.0 0.0 0.48 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDF36555.1 - 4e-21 75.3 0.1 8e-21 74.4 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF36555.1 - 1.1e-11 44.8 10.2 0.46 10.8 0.0 8.0 2 2 5 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF36555.1 - 4.3e-09 36.9 13.6 0.097 13.6 0.0 7.5 7 0 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 CDF36555.1 - 8.8e-07 29.0 0.1 5.8e-06 26.3 0.0 2.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 CDF36555.1 - 0.0018 17.9 12.8 0.0018 17.9 12.8 3.5 2 1 1 3 3 3 1 PQQ-like domain Lactonase PF10282.9 CDF36555.1 - 0.022 14.0 0.0 5 6.3 0.0 3.3 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller PQQ PF01011.21 CDF36555.1 - 0.031 14.2 11.2 0.57 10.2 0.1 4.6 4 0 0 4 4 4 0 PQQ enzyme repeat APAF1_C PF17908.1 CDF36555.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain PD40 PF07676.12 CDF36555.1 - 0.12 12.4 4.4 95 3.1 0.2 5.5 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF4045 PF13254.6 CDF36558.1 - 5.8 6.4 10.9 7.7 6.0 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DrrA_P4M PF14860.6 CDF36560.1 - 0.11 12.3 0.3 0.12 12.3 0.3 1.1 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain E2F_CC-MB PF16421.5 CDF36562.1 - 1e-27 96.3 0.0 1.7e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 CDF36562.1 - 1.3e-24 86.1 0.3 2.1e-24 85.4 0.3 1.3 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain APG6_N PF17675.1 CDF36562.1 - 0.033 14.7 0.5 0.066 13.7 0.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region TrmB PF01978.19 CDF36562.1 - 0.037 13.9 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB CLZ PF16526.5 CDF36562.1 - 0.11 12.9 0.7 3.9 7.9 0.0 3.0 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels zf-B_box PF00643.24 CDF36563.1 - 4e-09 36.5 18.3 0.00022 21.3 4.1 2.4 2 0 0 2 2 2 2 B-box zinc finger WD40 PF00400.32 CDF36564.1 - 1.4e-37 127.0 12.3 2.6e-08 34.4 0.1 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat NB-ARC PF00931.22 CDF36564.1 - 1.5e-13 50.5 0.0 2.9e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF36564.1 - 1.6e-10 41.2 4.1 0.011 16.0 0.1 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF36564.1 - 0.0015 17.2 5.4 13 4.2 0.1 4.9 2 1 2 5 5 5 2 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF36564.1 - 0.0016 18.7 0.0 0.0052 17.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain PQQ_3 PF13570.6 CDF36564.1 - 0.016 15.7 9.2 6 7.5 0.0 4.9 2 2 3 5 5 5 0 PQQ-like domain NACHT PF05729.12 CDF36564.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Cluap1 PF10234.9 CDF36564.1 - 0.42 10.0 1.4 0.81 9.0 1.4 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 COPIIcoated_ERV PF07970.12 CDF36566.1 - 5e-32 111.6 0.1 7.6e-32 110.9 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter Thioredoxin PF00085.20 CDF36566.1 - 6.8e-24 83.8 0.2 1.1e-23 83.2 0.2 1.3 1 0 0 1 1 1 1 Thioredoxin ERGIC_N PF13850.6 CDF36566.1 - 1e-21 77.1 0.4 3.1e-21 75.5 0.0 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Sucrose_synth PF00862.19 CDF36566.1 - 0.0099 14.2 0.0 0.014 13.8 0.0 1.1 1 0 0 1 1 1 1 Sucrose synthase Thioredoxin_2 PF13098.6 CDF36566.1 - 0.031 14.7 0.3 0.068 13.6 0.3 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDF36566.1 - 0.082 13.1 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_8 PF13905.6 CDF36566.1 - 0.11 12.9 0.1 0.4 11.0 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like OST3_OST6 PF04756.13 CDF36566.1 - 0.18 11.1 0.2 0.43 9.9 0.2 1.6 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Amino_oxidase PF01593.24 CDF36567.1 - 3.8e-51 174.8 0.0 4.3e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF36567.1 - 2.3e-08 34.1 0.0 5.2e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF36567.1 - 5.5e-05 22.9 0.0 0.00015 21.5 0.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDF36567.1 - 0.003 17.5 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CDF36567.1 - 0.0058 15.9 0.1 0.0092 15.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDF36567.1 - 0.044 13.0 0.0 0.068 12.4 0.0 1.2 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 CDF36567.1 - 0.051 12.9 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CDF36567.1 - 0.16 10.6 0.1 0.26 9.9 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein AstE_AspA PF04952.14 CDF36567.1 - 0.17 10.9 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family HEAT PF02985.22 CDF36568.1 - 0.0021 18.1 8.7 0.67 10.4 0.0 6.2 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 CDF36568.1 - 0.037 14.4 20.9 0.24 11.8 0.3 5.2 5 0 0 5 5 5 0 HEAT repeats GFO_IDH_MocA PF01408.22 CDF36569.1 - 4.8e-11 43.5 0.0 1e-10 42.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Piwi PF02171.17 CDF36570.1 - 7.5e-82 275.0 0.0 1.3e-81 274.2 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 CDF36570.1 - 6.6e-16 58.4 0.0 1.4e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CDF36570.1 - 9.6e-12 44.4 0.1 2.3e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 CDF36570.1 - 3.4e-10 40.1 0.0 1.3e-09 38.3 0.0 2.0 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoN PF16486.5 CDF36570.1 - 1.2e-09 38.9 0.0 6.3e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoMid PF16487.5 CDF36570.1 - 1.5e-08 34.8 0.0 6.1e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 Mid domain of argonaute DUF1989 PF09347.10 CDF36573.1 - 0.17 11.5 0.1 0.17 11.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) AhpC-TSA PF00578.21 CDF36574.1 - 0.02 14.8 0.1 0.034 14.1 0.1 1.3 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 CDF36574.1 - 0.09 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Redoxin EMP70 PF02990.16 CDF36575.1 - 2.9e-160 534.4 21.3 5.8e-110 368.4 21.7 2.1 1 1 1 2 2 2 2 Endomembrane protein 70 DUF2921 PF11145.8 CDF36575.1 - 0.93 7.2 3.4 7.5 4.3 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2921) EMP70 PF02990.16 CDF36576.1 - 4.7e-159 530.4 0.5 6e-159 530.0 0.5 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 Hema_stalk PF08720.10 CDF36576.1 - 0.18 11.5 0.2 0.31 10.7 0.2 1.3 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk E1-E2_ATPase PF00122.20 CDF36577.1 - 1.8e-42 144.9 0.2 3.8e-42 143.8 0.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CDF36577.1 - 4.3e-25 89.2 1.5 1.3e-24 87.7 1.5 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDF36577.1 - 3e-14 53.2 0.4 1.9e-09 37.8 0.1 3.0 3 0 0 3 3 3 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CDF36577.1 - 0.0094 15.7 0.8 0.056 13.2 0.7 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF36577.1 - 0.026 14.9 0.7 0.066 13.6 0.7 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Eno-Rase_NADH_b PF12242.8 CDF36577.1 - 0.18 11.6 0.6 0.78 9.5 0.1 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase APH PF01636.23 CDF36579.1 - 6e-08 32.9 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family YojJ PF10372.9 CDF36579.1 - 0.27 11.4 1.3 1.8 8.7 0.0 2.5 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus WD40 PF00400.32 CDF36581.1 - 5.1e-45 150.5 35.5 1.9e-06 28.5 1.6 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat TIR_2 PF13676.6 CDF36581.1 - 1.9e-17 63.9 0.0 1.6e-16 61.0 0.0 2.6 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF36581.1 - 2.4e-17 63.0 0.0 4.5e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF36581.1 - 3.5e-07 30.2 0.0 7.6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF36581.1 - 1.1e-05 25.6 9.7 0.018 15.3 0.1 5.3 1 1 5 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 CDF36581.1 - 0.0012 19.1 0.0 0.0031 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain Nup160 PF11715.8 CDF36581.1 - 0.0092 14.7 14.8 14 4.1 0.0 7.3 4 1 4 8 8 8 1 Nucleoporin Nup120/160 TIR-like PF10137.9 CDF36581.1 - 0.034 14.1 0.0 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Phycoerythr_ab PF02972.14 CDF36584.1 - 0.028 14.2 0.0 0.039 13.8 0.0 1.1 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain YqzE PF14038.6 CDF36585.1 - 0.24 11.4 1.3 3.3 7.8 0.0 2.4 2 0 0 2 2 2 0 YqzE-like protein Glyco_transf_7C PF02709.14 CDF36586.1 - 4.6e-06 26.2 0.1 9.6e-06 25.2 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDF36586.1 - 5.7e-06 26.0 0.0 0.00049 19.7 0.1 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDF36586.1 - 0.0018 18.1 0.0 0.0039 17.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 FAD_binding_3 PF01494.19 CDF36588.1 - 1.3e-09 37.8 0.0 1.6e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 CDF36588.1 - 0.0053 15.8 0.0 0.0082 15.2 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase DAP_epimerase PF01678.19 CDF36591.1 - 3.5e-53 178.9 0.0 1.6e-29 102.5 0.0 2.1 2 0 0 2 2 2 2 Diaminopimelate epimerase DHODB_Fe-S_bind PF10418.9 CDF36591.1 - 0.048 13.5 1.3 0.15 11.9 1.3 1.9 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B GTP1_OBG PF01018.22 CDF36592.1 - 1.5e-47 161.1 11.9 2.4e-47 160.4 10.9 1.8 2 0 0 2 2 2 1 GTP1/OBG MMR_HSR1 PF01926.23 CDF36592.1 - 8.5e-23 80.6 0.0 5.1e-22 78.1 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF1967 PF09269.11 CDF36592.1 - 4.5e-19 68.1 1.0 9.6e-19 67.1 1.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1967) FeoB_N PF02421.18 CDF36592.1 - 6.3e-09 35.5 0.0 1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 CDF36592.1 - 9.5e-06 25.2 0.3 0.0015 18.0 0.3 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_29 PF13555.6 CDF36592.1 - 0.027 14.2 0.0 0.091 12.5 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 CDF36592.1 - 0.058 13.5 0.0 4.5 7.3 0.0 3.0 2 1 1 3 3 3 0 Dynamin family DEAD PF00270.29 CDF36593.1 - 1.6e-36 125.7 0.0 2.6e-36 125.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF36593.1 - 3e-26 91.9 0.0 2.8e-25 88.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF36593.1 - 5.4e-07 29.8 0.0 9.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MFS_1 PF07690.16 CDF36594.1 - 3.9e-13 49.1 24.6 3.9e-13 49.1 24.6 2.3 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF3699 PF12480.8 CDF36594.1 - 0.061 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3699) Apolipoprotein PF01442.18 CDF36596.1 - 0.074 12.9 2.1 1.6 8.6 0.0 3.2 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain HisKA_3 PF07730.13 CDF36596.1 - 0.08 13.5 2.4 4.7 7.8 0.0 4.0 3 1 0 3 3 3 0 Histidine kinase DUF5610 PF18433.1 CDF36596.1 - 0.12 12.9 0.2 29 5.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5610) DUF5082 PF16888.5 CDF36596.1 - 0.35 11.2 1.9 15 5.9 0.0 3.4 3 2 0 3 3 3 0 Domain of unknown function (DUF5082) Vps51 PF08700.11 CDF36596.1 - 2.3 8.4 5.2 33 4.7 0.0 4.8 4 1 1 5 5 5 0 Vps51/Vps67 Laminin_II PF06009.12 CDF36596.1 - 4.6 7.3 15.6 2.8 8.0 3.7 4.1 3 1 1 4 4 4 0 Laminin Domain II Rieske PF00355.26 CDF36597.1 - 7.9e-12 45.0 0.0 1.4e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 CDF36597.1 - 1e-10 41.9 0.1 2.1e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region ETF_alpha PF00766.19 CDF36598.1 - 1.3e-35 121.2 1.3 1.3e-35 121.2 1.3 2.7 4 0 0 4 4 4 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 CDF36598.1 - 4.7e-27 95.1 10.2 7.3e-27 94.4 10.2 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Fe-ADH PF00465.19 CDF36599.1 - 4.6e-19 68.5 2.2 2e-17 63.1 0.1 2.3 2 1 0 2 2 2 2 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CDF36599.1 - 0.0089 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Pkinase PF00069.25 CDF36602.1 - 1.3e-68 231.2 0.0 1.7e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36602.1 - 8.2e-34 117.1 0.0 1.1e-33 116.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF36602.1 - 2.2e-05 23.4 0.0 3.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF36602.1 - 0.0027 17.7 1.1 1.4 8.8 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF36602.1 - 0.0093 15.3 0.1 0.03 13.6 0.0 1.8 2 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CDF36602.1 - 0.02 14.5 0.0 0.043 13.4 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PAH PF02671.21 CDF36603.1 - 2.9e-36 123.3 8.8 7.5e-17 61.2 3.3 4.1 3 1 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 CDF36603.1 - 2.8e-06 27.3 0.0 0.035 14.2 0.0 2.7 2 0 0 2 2 2 2 Sin3 family co-repressor WD40 PF00400.32 CDF36606.1 - 8.4e-64 210.0 37.1 6.2e-07 30.0 0.4 9.6 9 0 0 9 9 9 9 WD domain, G-beta repeat NB-ARC PF00931.22 CDF36606.1 - 2.9e-15 56.1 0.0 6.4e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF36606.1 - 7e-13 48.7 16.0 0.0014 18.9 0.0 7.9 1 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF36606.1 - 1.9e-10 40.1 12.4 1.2 7.7 0.0 8.7 7 1 2 9 9 9 5 Nucleoporin Nup120/160 TIR_2 PF13676.6 CDF36606.1 - 2.7e-05 24.8 0.0 0.00014 22.4 0.0 2.4 2 0 0 2 2 1 1 TIR domain TIR PF01582.20 CDF36606.1 - 0.00048 20.0 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 TIR domain AAA_22 PF13401.6 CDF36606.1 - 0.0023 18.2 0.0 0.0064 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain WD40_like PF17005.5 CDF36606.1 - 0.012 15.0 0.0 49 3.1 0.0 5.5 6 1 0 7 7 7 0 WD40-like domain PQQ_3 PF13570.6 CDF36606.1 - 0.056 14.0 21.5 6.2 7.4 0.1 7.7 1 1 8 9 9 9 0 PQQ-like domain WSC PF01822.19 CDF36606.1 - 0.11 12.7 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 WSC domain DUF4279 PF14106.6 CDF36606.1 - 0.3 11.3 10.4 1.6e+02 2.5 0.1 6.7 2 1 6 8 8 8 0 Domain of unknown function (DUF4279) WD40 PF00400.32 CDF36609.1 - 2.4e-57 189.5 34.4 4.8e-09 36.7 0.4 8.6 8 0 0 8 8 8 8 WD domain, G-beta repeat NB-ARC PF00931.22 CDF36609.1 - 7.5e-15 54.8 0.0 1.6e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF36609.1 - 8.5e-12 45.2 12.7 0.083 13.2 0.0 7.8 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF36609.1 - 1.2e-08 34.1 5.2 2.1 6.9 0.0 7.7 8 0 0 8 8 8 3 Nucleoporin Nup120/160 TIR_2 PF13676.6 CDF36609.1 - 2.2e-08 34.7 0.0 7.7e-08 33.0 0.0 2.0 1 0 0 1 1 1 1 TIR domain AAA_22 PF13401.6 CDF36609.1 - 0.0028 17.9 0.0 0.0079 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain WD40_like PF17005.5 CDF36609.1 - 0.024 14.0 0.0 65 2.7 0.0 4.6 6 0 0 6 6 6 0 WD40-like domain PQQ_3 PF13570.6 CDF36609.1 - 0.048 14.2 15.7 14 6.4 0.1 6.9 2 1 6 8 8 8 0 PQQ-like domain WSC PF01822.19 CDF36609.1 - 0.17 12.1 0.0 0.5 10.6 0.0 1.7 1 0 0 1 1 1 0 WSC domain Nucleoporin_N PF08801.11 CDF36609.1 - 0.38 9.5 1.7 12 4.5 0.0 3.7 1 1 3 4 4 4 0 Nup133 N terminal like DUF4279 PF14106.6 CDF36609.1 - 4 7.7 7.1 3.3e+02 1.5 0.0 5.5 2 1 5 7 7 7 0 Domain of unknown function (DUF4279) LDB19 PF13002.7 CDF36611.1 - 0.011 15.5 0.6 0.013 15.2 0.6 1.2 1 0 0 1 1 1 0 Arrestin_N terminal like Cupin_1 PF00190.22 CDF36615.1 - 5.3e-11 42.3 0.0 5.3e-11 42.3 0.0 1.0 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CDF36615.1 - 5.4e-07 29.2 0.0 7.8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CDF36615.1 - 0.01 15.5 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 CDF36615.1 - 0.15 11.9 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Helicase_C PF00271.31 CDF36618.1 - 2.2e-14 53.7 0.0 5.4e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF36618.1 - 1.1e-09 38.2 0.0 3.4e-09 36.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 CDF36618.1 - 2.9e-06 27.7 0.2 1.9e-05 25.0 0.2 2.5 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 CDF36618.1 - 0.0051 16.8 0.0 0.017 15.1 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit NAD_Gly3P_dh_C PF07479.14 CDF36618.1 - 0.0065 16.7 0.0 2.9 8.2 0.1 2.6 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus ABC_tran PF00005.27 CDF36620.1 - 3.6e-36 124.7 0.0 6.2e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 CDF36620.1 - 3.7e-05 23.1 0.0 0.00012 21.4 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 CDF36620.1 - 7.5e-05 23.0 0.1 0.00057 20.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF36620.1 - 0.00035 20.3 1.8 0.004 16.9 1.8 2.1 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDF36620.1 - 0.0013 18.2 0.2 0.075 12.5 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDF36620.1 - 0.0014 19.0 1.1 0.0041 17.5 1.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CDF36620.1 - 0.0074 16.0 0.0 0.009 15.8 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF36620.1 - 0.0083 15.8 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 CDF36620.1 - 0.0084 16.1 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CDF36620.1 - 0.0092 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain SbcCD_C PF13558.6 CDF36620.1 - 0.011 15.9 0.8 0.15 12.3 0.8 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 CDF36620.1 - 0.012 15.5 0.3 0.68 9.7 0.1 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDF36620.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 CDF36620.1 - 0.015 14.4 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit ABC_ATPase PF09818.9 CDF36620.1 - 0.022 13.6 0.1 0.038 12.8 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_28 PF13521.6 CDF36620.1 - 0.037 14.3 0.2 0.08 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDF36620.1 - 0.14 12.6 0.0 23 5.4 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDF36620.1 - 0.2 11.4 0.1 0.51 10.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain TOBE PF03459.17 CDF36621.1 - 0.048 13.9 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 TOBE domain Qn_am_d_aIII PF09099.10 CDF36621.1 - 0.31 11.5 2.4 0.28 11.6 0.6 1.8 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III SRP54 PF00448.22 CDF36623.1 - 1.2e-53 181.7 0.1 1.9e-53 181.0 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 CDF36623.1 - 3e-29 102.9 0.3 1.1e-28 101.0 0.3 1.8 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal MeaB PF03308.16 CDF36623.1 - 4.9e-09 35.6 0.1 1.1e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 CDF36623.1 - 1.8e-06 28.0 0.0 0.00037 20.6 0.1 3.1 2 2 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54_N PF02881.19 CDF36623.1 - 2.3e-06 27.7 0.2 6.2e-06 26.4 0.2 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 CDF36623.1 - 0.00017 21.4 0.1 0.00031 20.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain VirC1 PF07015.11 CDF36623.1 - 0.012 14.9 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 VirC1 protein CLP1_P PF16575.5 CDF36623.1 - 0.025 14.4 0.3 6.9 6.4 0.0 3.0 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 CDF36623.1 - 0.028 14.2 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Fer4_NifH PF00142.18 CDF36623.1 - 0.041 13.3 0.6 0.082 12.3 0.1 1.7 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_33 PF13671.6 CDF36623.1 - 0.059 13.5 0.1 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CDF36623.1 - 0.084 12.8 0.9 1 9.3 0.1 2.6 2 1 0 2 2 2 0 NTPase ArsA_ATPase PF02374.15 CDF36623.1 - 0.13 11.4 0.9 1.7 7.7 0.0 2.6 3 0 0 3 3 3 0 Anion-transporting ATPase NAD_binding_10 PF13460.6 CDF36623.1 - 0.87 9.5 3.8 0.92 9.4 0.2 2.6 3 0 0 3 3 3 0 NAD(P)H-binding Antimicrobial10 PF08105.11 CDF36625.1 - 0.074 13.1 0.2 0.087 12.9 0.2 1.2 1 0 0 1 1 1 0 Metchnikowin family QueF PF14489.6 CDF36628.1 - 1.7e-31 108.2 0.0 2.3e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 QueF-like protein QueF_N PF14819.6 CDF36628.1 - 0.0082 16.4 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term ATP-synt_ab PF00006.25 CDF36629.1 - 3.2e-67 226.3 0.0 5.2e-67 225.6 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDF36629.1 - 3.2e-13 50.0 0.7 5.5e-13 49.2 0.7 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain APG6_N PF17675.1 CDF36630.1 - 0.013 16.0 11.8 0.18 12.3 4.5 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Med9 PF07544.13 CDF36633.1 - 9.5e-05 22.4 0.8 0.00012 22.1 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 CDF36633.1 - 0.0046 17.2 2.0 0.0078 16.5 0.2 1.9 1 1 1 2 2 2 1 Subunit 21 of Mediator complex THOC7 PF05615.13 CDF36633.1 - 0.016 15.5 0.4 0.026 14.8 0.4 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 FAM117 PF15388.6 CDF36633.1 - 0.73 9.2 2.5 1.2 8.5 2.5 1.5 1 1 0 1 1 1 0 Protein Family FAM117 Arf PF00025.21 CDF36634.1 - 8.6e-48 162.1 0.0 1e-47 161.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDF36634.1 - 3.1e-09 36.5 0.0 3.7e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CDF36634.1 - 1.3e-08 34.6 0.0 1.5e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF36634.1 - 1.3e-08 35.0 0.0 2.2e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDF36634.1 - 2.3e-06 27.0 0.0 3.1e-05 23.3 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 CDF36634.1 - 0.00016 21.8 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF36634.1 - 0.00054 19.4 0.0 0.00065 19.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Cas_APE2256 PF09651.10 CDF36634.1 - 0.15 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) Mu-like_Com PF10122.9 CDF36635.1 - 0.014 14.9 0.0 0.48 9.9 0.0 2.5 2 0 0 2 2 2 0 Mu-like prophage protein Com RWD PF05773.22 CDF36637.1 - 2.2e-10 40.8 0.0 3.3e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 RWD domain zf-RING_UBOX PF13445.6 CDF36637.1 - 5.6e-05 23.1 1.9 0.00032 20.6 0.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CDF36637.1 - 0.00044 20.5 4.5 0.0059 16.9 4.5 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF36637.1 - 0.00068 19.5 2.1 0.00093 19.0 0.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF36637.1 - 0.0066 16.4 1.7 0.055 13.4 1.8 2.1 1 1 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CDF36637.1 - 0.057 13.5 0.4 8.6 6.5 0.3 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CDF36637.1 - 0.11 12.3 0.6 8.7 6.2 0.2 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 CDF36637.1 - 0.12 12.3 2.0 1.1 9.1 0.0 2.6 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RING_11 PF17123.5 CDF36637.1 - 0.26 11.1 4.1 0.1 12.4 1.0 1.9 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 CDF36637.1 - 0.89 9.5 7.1 23 4.9 0.2 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CDF36637.1 - 2.2 8.2 8.5 1.5 8.8 3.2 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDF36637.1 - 3.9 7.2 6.4 0.7 9.6 2.3 1.9 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type ATP11 PF06644.11 CDF36638.1 - 1.3e-29 103.8 0.0 1.5e-29 103.6 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein DUF3437 PF11919.8 CDF36638.1 - 0.12 12.3 0.1 2.9 7.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) DUF2784 PF10861.8 CDF36638.1 - 0.19 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) Dynamin_N PF00350.23 CDF36639.1 - 8.6e-12 45.4 0.0 4.2e-11 43.2 0.0 2.1 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 CDF36639.1 - 3.4e-06 26.7 0.0 8.3e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDF36639.1 - 0.0038 17.3 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF36639.1 - 0.0068 16.3 0.1 0.049 13.5 0.0 2.3 1 1 1 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 CDF36639.1 - 0.013 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AIG1 PF04548.16 CDF36639.1 - 0.02 14.3 0.0 0.047 13.0 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Exog_C PF18026.1 CDF36639.1 - 0.17 12.0 0.2 0.61 10.2 0.0 2.1 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Apolipoprotein PF01442.18 CDF36639.1 - 0.51 10.2 6.2 0.56 10.1 0.3 2.9 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain SpoU_methylase PF00588.19 CDF36641.1 - 8.4e-25 87.6 0.0 2.4e-18 66.7 0.0 2.3 2 0 0 2 2 2 2 SpoU rRNA Methylase family HAD_2 PF13419.6 CDF36641.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Tim17 PF02466.19 CDF36642.1 - 1e-20 74.1 1.0 1.3e-20 73.9 1.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PAF PF15715.5 CDF36644.1 - 0.16 12.6 1.9 0.15 12.6 1.9 1.2 1 1 0 1 1 1 0 PCNA-associated factor histone like domain HA2 PF04408.23 CDF36646.1 - 6.1e-20 71.5 0.0 1.5e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDF36646.1 - 4.7e-17 62.1 0.0 9.4e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDF36646.1 - 7.3e-11 42.4 0.0 1.6e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF36646.1 - 8.6e-08 32.1 0.0 1.3e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDF36646.1 - 2.6e-05 24.5 0.3 7e-05 23.1 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDF36646.1 - 0.0027 18.1 0.1 0.0051 17.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF36646.1 - 0.0073 16.1 0.2 0.013 15.3 0.2 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CDF36646.1 - 0.042 13.1 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 CDF36646.1 - 0.06 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 CDF36646.1 - 0.061 12.4 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 CDF36646.1 - 0.091 12.4 0.4 0.22 11.1 0.4 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Extensin_2 PF04554.13 CDF36646.1 - 0.31 11.2 4.0 1.1 9.4 4.0 1.9 1 0 0 1 1 1 0 Extensin-like region POPLD PF08170.12 CDF36650.1 - 1.6e-13 50.8 0.6 6.3e-13 48.9 0.0 2.0 1 1 1 2 2 2 1 POPLD (NUC188) domain GCV_T_C PF08669.11 CDF36650.1 - 0.014 15.3 0.2 0.028 14.4 0.2 1.5 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain zf-UDP PF14569.6 CDF36651.1 - 0.034 14.3 1.0 0.038 14.1 1.0 1.2 1 1 0 1 1 1 0 Zinc-binding RING-finger Metallophos PF00149.28 CDF36652.1 - 2.3e-11 44.6 0.1 3.2e-11 44.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDF36652.1 - 7e-06 26.3 0.1 0.00017 21.8 0.1 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 CDF36652.1 - 0.1 11.6 0.0 1.1 8.3 0.0 2.0 2 0 0 2 2 2 0 PhoD-like phosphatase SET PF00856.28 CDF36654.1 - 5.6e-05 23.6 0.0 0.00012 22.5 0.0 1.6 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 CDF36654.1 - 0.038 14.7 0.2 0.072 13.8 0.2 1.6 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding DUF5388 PF17363.2 CDF36654.1 - 0.043 14.0 0.1 0.097 12.9 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5388) GTP_cyclohydroI PF01227.22 CDF36654.1 - 0.087 12.2 0.4 0.16 11.4 0.4 1.4 1 0 0 1 1 1 0 GTP cyclohydrolase I DUF3613 PF12266.8 CDF36657.1 - 0.035 13.9 0.3 0.057 13.2 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3613) Sel1 PF08238.12 CDF36659.1 - 1.1e-69 229.3 17.4 2.2e-06 28.1 0.1 11.6 11 0 0 11 11 11 11 Sel1 repeat TPR_17 PF13431.6 CDF36659.1 - 5.9e-10 38.8 6.5 21 5.8 0.1 11.2 11 5 0 11 11 11 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF36659.1 - 4.9e-09 36.2 21.0 1.3 9.8 0.2 9.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36659.1 - 2.4e-08 34.5 17.9 1.4 9.6 0.2 9.1 4 2 6 10 10 10 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF36659.1 - 0.014 15.4 17.0 5.2 7.3 0.1 9.2 10 0 0 10 10 10 0 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF36659.1 - 0.032 14.5 2.0 92 3.4 0.0 4.9 2 2 1 5 5 5 0 Arginine decarboxylase helical bundle domain TPR_14 PF13428.6 CDF36659.1 - 0.063 14.1 14.1 2.3 9.3 0.7 7.8 7 2 2 9 9 9 0 Tetratricopeptide repeat HTH_Bact PF18768.1 CDF36659.1 - 0.067 12.8 5.9 5.5 6.6 0.0 5.0 3 2 3 6 6 6 0 Helix-turn-helix bacterial domain Ig_3 PF13927.6 CDF36663.1 - 0.034 14.7 0.2 0.2 12.3 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Sel1 PF08238.12 CDF36664.1 - 1.5e-100 327.3 26.9 1.4e-05 25.6 0.1 17.5 17 0 0 17 17 17 17 Sel1 repeat TPR_17 PF13431.6 CDF36664.1 - 1.2e-14 53.5 0.0 27 5.4 0.0 14.9 14 5 1 15 15 15 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36664.1 - 2.7e-09 37.5 14.5 1.5 9.5 0.1 11.9 8 4 6 14 14 14 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF36664.1 - 8.5e-08 32.4 41.7 6.4 7.6 0.0 15.6 17 0 0 17 17 17 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF36664.1 - 0.035 14.9 19.7 5.4 8.1 0.7 11.0 14 1 1 15 15 15 0 Tetratricopeptide repeat HipN PF18253.1 CDF36665.1 - 0.04 13.6 0.8 19 5.0 0.0 4.2 5 0 0 5 5 5 0 Hsp70-interacting protein N N-terminal domain SnoaL_2 PF12680.7 CDF36667.1 - 0.22 12.2 2.2 0.55 10.9 2.2 1.7 1 1 0 1 1 1 0 SnoaL-like domain Sel1 PF08238.12 CDF36669.1 - 1.4e-53 178.1 9.4 3.9e-06 27.3 0.0 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.6 CDF36669.1 - 2.6e-15 55.9 16.9 1.4 9.7 0.0 10.2 9 2 1 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36669.1 - 5.7e-12 46.1 31.1 0.16 12.7 0.0 8.1 5 3 3 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 CDF36669.1 - 1.7e-09 37.0 17.3 2.1 8.6 0.0 9.1 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF36669.1 - 1.1e-06 28.6 0.7 6.4 7.4 0.0 8.3 8 4 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF36669.1 - 5.3e-06 26.8 27.0 15 6.7 0.0 9.5 7 3 3 10 10 10 0 Tetratricopeptide repeat MIT PF04212.18 CDF36669.1 - 2.3e-05 24.4 9.2 16 5.7 0.0 7.1 8 0 0 8 8 8 0 MIT (microtubule interacting and transport) domain NSF PF02071.20 CDF36669.1 - 0.00029 21.0 8.2 2.2e+02 3.4 0.0 8.3 8 0 0 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat Arg_decarb_HB PF17810.1 CDF36669.1 - 0.03 14.6 3.6 14 6.0 0.0 4.4 3 1 1 5 5 5 0 Arginine decarboxylase helical bundle domain TPR_2 PF07719.17 CDF36669.1 - 0.052 13.7 25.0 29 5.1 0.0 9.3 9 0 0 9 9 9 0 Tetratricopeptide repeat HEPN_Apea PF18739.1 CDF36669.1 - 0.094 13.2 0.1 1.8e+02 2.6 0.0 4.6 4 2 1 5 5 5 0 Apea-like HEPN FlaC_arch PF05377.11 CDF36669.1 - 0.14 12.6 0.0 1.3e+02 3.0 0.0 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) SSPI PF14098.6 CDF36669.1 - 0.2 11.9 0.3 2.3 8.5 0.0 2.6 3 0 0 3 3 3 0 Small, acid-soluble spore protein I TPR_1 PF00515.28 CDF36669.1 - 0.83 9.6 17.0 19 5.3 0.0 7.4 9 0 0 9 9 8 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 CDF36669.1 - 1.9 8.6 8.1 20 5.4 0.0 5.7 9 0 0 9 9 9 0 Exonuclease VII small subunit Sel1 PF08238.12 CDF36670.1 - 9.9e-05 22.9 0.1 0.66 10.7 0.0 2.2 2 0 0 2 2 2 2 Sel1 repeat TPM_phosphatase PF04536.14 CDF36672.1 - 1.1e-11 44.9 0.0 1.9e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 TPM domain zf-RING_2 PF13639.6 CDF36672.1 - 1.4e-10 41.3 8.7 3.1e-09 37.0 1.3 2.9 3 0 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.7 CDF36672.1 - 1.8e-09 37.7 2.9 1.4e-08 34.9 0.9 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDF36672.1 - 1.1e-08 34.8 4.0 2.1e-07 30.7 0.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF36672.1 - 6.9e-08 32.1 8.5 1.8e-05 24.4 0.1 4.1 4 0 0 4 4 4 2 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF36672.1 - 1.2e-07 31.5 5.4 1.1e-06 28.4 1.8 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDF36672.1 - 1.9e-07 31.0 1.8 2.4e-07 30.7 0.2 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 CDF36672.1 - 8.6e-06 25.6 6.9 1.1e-05 25.3 1.1 2.6 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF36672.1 - 2.3e-05 24.2 6.6 0.00073 19.4 0.8 2.6 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDF36672.1 - 0.00029 20.6 0.5 0.00029 20.6 0.5 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDF36672.1 - 0.00047 20.2 5.6 0.0013 18.8 1.7 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CDF36672.1 - 0.00048 20.1 12.5 0.0013 18.7 2.0 3.7 3 1 1 4 4 4 2 RING-type zinc-finger RINGv PF12906.7 CDF36672.1 - 0.0052 16.9 1.9 0.0052 16.9 1.9 2.2 2 1 1 3 3 3 1 RING-variant domain DUF1644 PF07800.12 CDF36672.1 - 0.011 15.8 0.2 0.028 14.5 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) MOLO1 PF17175.4 CDF36672.1 - 0.02 15.0 0.2 0.054 13.6 0.0 1.8 2 0 0 2 2 2 0 Modulator of levamisole receptor-1 Zn_ribbon_17 PF17120.5 CDF36672.1 - 0.03 13.9 0.9 0.03 13.9 0.9 1.8 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 CDF36672.1 - 0.031 14.1 2.1 0.13 12.1 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-TFIIIC PF12660.7 CDF36672.1 - 0.036 14.0 0.9 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex Prok-RING_1 PF14446.6 CDF36672.1 - 0.21 11.5 4.6 30 4.6 0.1 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 CDF36672.1 - 0.6 9.9 6.0 0.28 11.0 0.5 2.5 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CDF36672.1 - 0.9 9.8 10.6 0.31 11.2 3.0 3.3 3 1 0 3 3 3 0 FANCL C-terminal domain bZIP_2 PF07716.15 CDF36674.1 - 1.8e-07 31.2 12.1 1.8e-07 31.2 12.1 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CDF36674.1 - 7.4e-07 29.2 14.5 1.2e-06 28.4 14.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor COPI_C PF06957.11 CDF36675.1 - 0.0026 16.6 0.4 0.0043 15.9 0.4 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CDF36677.1 - 6.9e-10 39.4 3.4 0.11 13.4 0.0 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF36677.1 - 2e-05 24.8 0.0 0.48 10.7 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Caa3_CtaG PF09678.10 CDF36677.1 - 0.032 13.7 1.4 0.058 12.8 1.4 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) GMC_oxred_N PF00732.19 CDF36680.1 - 4.1e-35 121.6 0.0 7e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CDF36680.1 - 1.6e-14 54.7 0.0 2.6e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CDF36680.1 - 0.00099 18.8 0.0 0.012 15.2 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDF36680.1 - 0.0024 17.0 0.0 0.004 16.3 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CDF36680.1 - 0.01 16.1 0.0 0.032 14.5 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CDF36680.1 - 0.017 15.1 0.0 0.24 11.4 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding RT_RNaseH_2 PF17919.1 CDF36681.1 - 9.8e-29 99.3 0.0 1.9e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF36681.1 - 7.2e-26 90.5 0.2 1.3e-25 89.7 0.2 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF36681.1 - 0.0046 16.5 0.0 0.027 14.0 0.0 2.1 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) TRAF_BIRC3_bd PF16673.5 CDF36682.1 - 0.026 14.3 0.7 5.2 6.9 0.0 2.4 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain BK_channel_a PF03493.18 CDF36684.1 - 2.3e-11 43.8 0.0 4e-10 39.8 0.0 2.5 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 CDF36684.1 - 7.3e-11 41.9 4.3 2.7e-10 40.1 4.3 1.9 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 CDF36684.1 - 0.0023 18.2 0.0 0.61 10.4 0.0 2.6 2 0 0 2 2 2 2 TrkA-N domain DUF3961 PF13106.6 CDF36684.1 - 0.47 10.1 2.1 1.2 8.9 2.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) DUF4479 PF14794.6 CDF36686.1 - 0.016 15.1 0.1 0.018 14.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) EMP70 PF02990.16 CDF36687.1 - 1.4e-136 456.2 2.9 2.2e-136 455.6 2.9 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 zf-RING_2 PF13639.6 CDF36689.1 - 1.1e-12 48.0 7.7 1.9e-12 47.3 7.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF36689.1 - 1.2e-11 44.8 7.3 2e-11 44.0 7.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDF36689.1 - 3e-10 39.8 7.1 4.7e-10 39.1 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF36689.1 - 5.1e-08 32.5 4.0 1.1e-07 31.5 4.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDF36689.1 - 1.8e-07 30.9 7.4 3.3e-07 30.1 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF36689.1 - 2.3e-07 30.7 3.1 3.8e-07 30.0 3.1 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDF36689.1 - 4.8e-06 26.3 6.7 7.8e-06 25.7 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDF36689.1 - 7.3e-06 25.9 4.4 1.1e-05 25.4 4.4 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 CDF36689.1 - 5.6e-05 23.0 7.1 0.00011 22.1 7.0 1.5 1 1 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDF36689.1 - 0.00077 19.0 8.9 0.0014 18.2 8.9 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 CDF36689.1 - 0.0021 17.8 3.6 0.0033 17.2 2.6 1.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 CDF36689.1 - 0.019 15.1 7.9 0.046 13.8 7.7 1.7 1 1 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 CDF36689.1 - 0.024 14.7 7.6 0.065 13.3 7.6 1.8 1 1 0 1 1 1 0 Zinc-finger zf-C3HC4_4 PF15227.6 CDF36689.1 - 0.042 14.0 2.6 0.11 12.7 2.6 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 CDF36689.1 - 0.065 13.6 9.5 0.13 12.5 9.2 1.7 1 1 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 CDF36689.1 - 0.14 12.1 6.8 0.41 10.6 3.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zf_RING PF16744.5 CDF36689.1 - 0.14 12.2 5.7 0.27 11.4 5.7 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger PHD PF00628.29 CDF36689.1 - 0.15 11.9 6.6 0.31 11.0 6.6 1.6 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 CDF36689.1 - 0.57 10.1 8.8 2.9 7.8 8.5 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CDF36689.1 - 0.67 9.8 6.6 2.6 7.9 6.7 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CDF36689.1 - 1.2 9.3 9.3 5 7.4 9.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain PTH2 PF01981.16 CDF36691.1 - 5.8e-26 91.1 0.5 7.2e-26 90.8 0.5 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF21 PF01595.20 CDF36692.1 - 2.3e-33 115.3 2.1 3.9e-33 114.6 2.1 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CDF36692.1 - 0.00039 20.8 0.3 0.0069 16.8 0.0 2.5 2 0 0 2 2 2 1 CBS domain NDK PF00334.19 CDF36693.1 - 2.4e-52 176.5 0.0 2.7e-52 176.3 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 CDF36693.1 - 0.0083 16.6 0.0 0.014 15.9 0.0 1.3 1 0 0 1 1 1 1 Photosystem I reaction centre subunit IX / PsaJ Mito_carr PF00153.27 CDF36694.1 - 6.4e-57 189.5 2.4 1.4e-18 66.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMGL-like PF00682.19 CDF36695.1 - 9.1e-44 150.0 0.0 1.2e-43 149.6 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CDF36695.1 - 1e-17 64.3 0.0 2.1e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Rbx_binding PF18113.1 CDF36696.1 - 0.32 10.8 1.3 2.5 8.0 0.1 3.2 3 1 1 4 4 4 0 Rubredoxin binding C-terminal domain OB_NTP_bind PF07717.16 CDF36697.1 - 3.9e-18 65.6 0.0 8.8e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CDF36697.1 - 2e-13 50.5 0.8 6e-13 49.0 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDF36697.1 - 3.9e-13 49.7 0.0 1.6e-12 47.7 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF36697.1 - 1.9e-10 40.8 0.2 4.4e-10 39.6 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDF36697.1 - 4.4e-07 30.3 0.6 8.2e-05 23.0 0.1 2.5 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDF36697.1 - 0.00057 19.0 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ATPase PF06745.13 CDF36697.1 - 0.00076 18.9 0.0 0.0019 17.6 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 CDF36697.1 - 0.0069 16.7 0.4 0.071 13.4 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDF36697.1 - 0.0081 15.9 1.5 0.013 15.3 0.1 2.0 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CDF36697.1 - 0.053 13.5 0.2 0.22 11.5 0.0 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.18 CDF36697.1 - 0.066 12.6 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family PhoH PF02562.16 CDF36697.1 - 0.097 12.1 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Herpes_ori_bp PF02399.15 CDF36697.1 - 0.13 10.3 0.1 0.21 9.6 0.1 1.1 1 0 0 1 1 1 0 Origin of replication binding protein BNR PF02012.20 CDF36699.1 - 0.0079 16.0 0.1 0.025 14.5 0.1 1.9 1 0 0 1 1 1 1 BNR/Asp-box repeat SMP_LBD PF17047.5 CDF36700.1 - 2.1e-22 79.5 0.0 2.7e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain ATP-sulfurylase PF01747.17 CDF36701.1 - 4.4e-59 199.5 0.0 6.5e-59 199.0 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 CDF36701.1 - 4.5e-30 104.4 0.0 9.1e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain E2F_TDP PF02319.20 CDF36702.1 - 2.9e-34 116.9 0.3 9.9e-18 64.0 0.0 2.5 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 CDF36702.1 - 0.0019 18.0 0.1 0.018 14.9 0.0 2.2 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 CDF36702.1 - 0.057 13.6 0.6 25 5.1 0.0 3.4 4 0 0 4 4 4 0 B-block binding subunit of TFIIIC Transketolase_N PF00456.21 CDF36704.1 - 9.8e-120 399.5 0.0 1.8e-118 395.3 0.0 2.2 1 1 1 2 2 2 2 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CDF36704.1 - 6.6e-37 126.9 0.1 1.3e-36 125.9 0.1 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDF36704.1 - 4.7e-06 26.5 0.0 0.00012 21.9 0.0 2.3 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CDF36704.1 - 0.00038 19.7 0.0 0.00067 18.9 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 CDF36704.1 - 0.094 12.5 0.1 0.26 11.1 0.1 1.8 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CtIP_N PF10482.9 CDF36705.1 - 0.1 12.7 1.9 0.19 11.7 1.9 1.4 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Rep_fac-A_3 PF08661.11 CDF36706.1 - 1.4e-08 35.0 0.1 4.7e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Replication factor A protein 3 tRNA_anti_2 PF13742.6 CDF36706.1 - 0.15 12.3 0.1 0.26 11.5 0.1 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain CRAL_TRIO PF00650.20 CDF36708.1 - 3.6e-22 78.8 0.2 7.6e-22 77.7 0.1 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDF36708.1 - 2.1e-06 28.0 0.0 5e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CDF36708.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain DUF3070 PF11270.8 CDF36709.1 - 0.058 13.6 5.0 0.077 13.2 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3070) DUF4918 PF16265.5 CDF36711.1 - 4.5e-08 32.9 0.0 0.00024 20.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4918) Plant_tran PF04827.14 CDF36713.1 - 5.2e-42 143.8 0.0 6.3e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF36713.1 - 2.5e-07 30.5 0.0 4.6e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Cellulase PF00150.18 CDF36715.1 - 3.2e-44 151.5 0.3 4.1e-44 151.1 0.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ANAPC4_WD40 PF12894.7 CDF36716.1 - 2.1e-09 37.6 0.0 0.041 14.2 0.0 3.7 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF36716.1 - 2.8e-08 34.3 1.3 5.3e-06 27.1 0.4 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CDF36716.1 - 0.012 14.6 0.4 0.08 11.9 0.0 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CDF36716.1 - 0.036 14.0 2.1 0.68 9.9 0.1 2.8 2 1 0 2 2 2 0 WD40-like Beta Propeller Repeat 5_nucleotid_C PF02872.18 CDF36718.1 - 0.028 14.6 0.0 0.058 13.6 0.0 1.4 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain Topo-VIb_trans PF09239.11 CDF36719.1 - 3.3e-49 166.8 0.0 6.2e-49 165.9 0.0 1.5 1 0 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c_3 PF13589.6 CDF36719.1 - 2.8e-06 27.2 1.6 2.7e-05 24.0 0.1 2.6 1 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDF36719.1 - 2.2e-05 24.9 0.0 0.00023 21.7 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RPA_C PF08784.11 CDF36720.1 - 6.9e-12 45.9 0.1 9.2e-12 45.5 0.1 1.2 1 0 0 1 1 1 1 Replication protein A C terminal PTCB-BRCT PF12738.7 CDF36721.1 - 6.9e-41 138.0 6.9 6.8e-16 58.0 0.0 5.4 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.26 CDF36721.1 - 1.9e-28 98.7 0.0 5.2e-07 29.9 0.0 5.7 5 0 0 5 5 5 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDF36721.1 - 6.1e-24 84.2 0.0 1.5e-05 25.3 0.0 5.2 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 CDF36721.1 - 2.4e-11 43.6 0.2 0.0027 17.8 0.0 4.4 4 0 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CDF36721.1 - 4.4e-09 36.5 0.5 0.26 11.6 0.1 5.0 5 0 0 5 5 5 3 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 CDF36721.1 - 1.2e-05 25.1 0.0 2.6 8.0 0.0 4.1 4 0 0 4 4 4 3 Regulator of Ty1 transposition protein 107 BRCT domain NOP5NT PF08156.13 CDF36723.1 - 0.27 11.7 2.3 0.29 11.6 0.5 1.9 2 0 0 2 2 2 0 NOP5NT (NUC127) domain TPT PF03151.16 CDF36724.1 - 1.2e-47 162.7 19.8 2.1e-47 161.9 19.8 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDF36724.1 - 4.6e-11 43.0 31.3 2.1e-05 24.7 13.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF4134 PF13572.6 CDF36724.1 - 0.12 12.6 0.4 0.12 12.6 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) Beta-lactamase PF00144.24 CDF36728.1 - 3.4e-48 164.6 0.0 1.7e-47 162.3 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase ABC1 PF03109.16 CDF36728.1 - 1.9e-23 82.8 0.0 5.2e-23 81.5 0.0 1.7 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.11 CDF36728.1 - 0.0013 18.4 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.23 CDF36728.1 - 0.53 10.2 4.2 2.3 8.1 0.0 3.4 4 1 0 4 4 4 0 Phosphotransferase enzyme family PTPLA PF04387.14 CDF36729.1 - 4.9e-58 195.5 7.6 5.8e-58 195.3 7.6 1.1 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA HAD_2 PF13419.6 CDF36730.1 - 1.2e-20 74.3 0.0 3.2e-20 73.0 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF36730.1 - 1.3e-19 71.3 0.7 3.5e-19 69.9 0.7 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF36730.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CDF36730.1 - 4.9e-05 23.8 0.0 0.00017 22.1 0.1 1.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDF36730.1 - 0.0025 17.9 0.0 3.2 7.9 0.0 2.5 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Resolvase PF00239.21 CDF36730.1 - 0.039 14.0 0.0 0.063 13.4 0.0 1.5 1 1 0 1 1 1 0 Resolvase, N terminal domain PrpR_N PF06506.11 CDF36730.1 - 0.053 13.1 0.2 9 5.8 0.0 2.3 2 0 0 2 2 2 0 Propionate catabolism activator HAD_2 PF13419.6 CDF36731.1 - 2.1e-20 73.6 0.0 5e-20 72.3 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF36731.1 - 2e-19 70.7 0.6 5.1e-19 69.4 0.6 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF36731.1 - 1.5e-06 28.2 0.0 3.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CDF36731.1 - 7.9e-05 23.1 0.0 0.00029 21.3 0.0 1.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDF36731.1 - 0.0039 17.3 0.0 3.9 7.6 0.0 2.5 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Resolvase PF00239.21 CDF36731.1 - 0.035 14.2 0.0 0.09 12.9 0.0 1.8 2 0 0 2 2 2 0 Resolvase, N terminal domain PrpR_N PF06506.11 CDF36731.1 - 0.081 12.5 0.2 11 5.5 0.0 2.3 2 0 0 2 2 2 0 Propionate catabolism activator Ku PF02735.16 CDF36732.1 - 1.5e-27 96.7 0.0 6.5e-27 94.6 0.0 1.9 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CDF36732.1 - 8.7e-21 74.7 0.0 1.4e-18 67.5 0.0 2.4 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 CDF36732.1 - 9.4e-07 29.5 0.2 3.7e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 CDF36732.1 - 0.00023 20.8 0.1 0.0007 19.3 0.1 2.0 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 CDF36734.1 - 0.0075 16.0 1.7 0.83 9.4 0.1 3.1 4 0 0 4 4 4 2 HeH/LEM domain Ish1 PF10281.9 CDF36734.1 - 0.022 15.0 0.0 0.23 11.8 0.1 2.5 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Dynein_light PF01221.18 CDF36735.1 - 6.5e-35 119.3 0.0 7.6e-35 119.1 0.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 DUF1198 PF06711.11 CDF36735.1 - 0.18 11.8 0.1 0.24 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) DUF382 PF04037.13 CDF36736.1 - 2.8e-48 163.3 0.1 6.5e-48 162.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 CDF36736.1 - 1e-20 73.3 1.8 2e-20 72.4 1.8 1.5 1 0 0 1 1 1 1 PSP AsnC_trans_reg PF01037.21 CDF36736.1 - 0.027 14.4 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain Metallophos PF00149.28 CDF36737.1 - 3.9e-38 132.0 0.3 5.2e-38 131.6 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDF36737.1 - 0.005 17.3 0.0 0.011 16.2 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Ferritin PF00210.24 CDF36738.1 - 3.8e-30 104.7 3.9 4.7e-30 104.4 3.9 1.1 1 0 0 1 1 1 1 Ferritin-like domain NMT1_3 PF16868.5 CDF36738.1 - 0.0033 16.9 0.1 0.0044 16.5 0.1 1.1 1 0 0 1 1 1 1 NMT1-like family Rubrerythrin PF02915.17 CDF36738.1 - 0.01 16.2 0.8 0.016 15.6 0.8 1.3 1 0 0 1 1 1 0 Rubrerythrin La PF05383.17 CDF36739.1 - 5.6e-13 48.7 0.0 1.1e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 La domain La PF05383.17 CDF36740.1 - 9.1e-13 48.1 0.0 1.6e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 La domain BLM10_mid PF16507.5 CDF36742.1 - 8.8e-51 173.1 0.0 6e-40 137.4 0.0 2.5 2 0 0 2 2 2 2 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 CDF36742.1 - 4e-30 103.6 0.0 3.2e-29 100.7 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) HEAT PF02985.22 CDF36742.1 - 7.9e-05 22.6 7.4 0.63 10.5 0.2 6.2 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 CDF36742.1 - 0.031 14.8 2.3 88 3.8 0.0 6.1 7 0 0 7 7 7 0 HEAT-like repeat CLASP_N PF12348.8 CDF36742.1 - 0.12 12.0 0.6 0.36 10.4 0.1 2.1 2 0 0 2 2 2 0 CLASP N terminal Mpv17_PMP22 PF04117.12 CDF36743.1 - 6.1e-13 48.8 3.4 1.1e-12 48.0 3.4 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family tRNA-synt_1b PF00579.25 CDF36745.1 - 8.3e-22 77.8 0.0 2e-21 76.6 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Arm PF00514.23 CDF36746.1 - 3.6e-19 68.1 0.0 0.001 19.1 0.0 9.3 10 0 0 10 10 10 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 CDF36746.1 - 9.4e-15 54.4 3.7 0.0013 18.7 0.1 5.7 3 1 4 7 7 7 6 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.8 CDF36746.1 - 2.7e-05 24.1 2.1 6.2 6.7 0.0 4.3 3 2 1 4 4 4 3 Domain of unknown function (DUF3361) HEAT_2 PF13646.6 CDF36746.1 - 3e-05 24.3 0.0 21 5.6 0.0 5.1 4 1 1 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 CDF36746.1 - 0.0025 18.3 0.4 9.2 6.9 0.0 5.6 6 0 0 6 6 6 1 HEAT-like repeat Asp PF00026.23 CDF36747.1 - 9.5e-35 120.5 0.0 1.8e-34 119.6 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDF36747.1 - 7.6e-13 49.1 1.2 7.6e-13 49.1 1.2 2.4 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CDF36747.1 - 1.4e-10 41.2 0.0 2.4e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 CDF36747.1 - 0.0061 17.1 0.0 0.04 14.5 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDF36747.1 - 0.014 16.0 0.2 0.13 12.9 0.0 2.5 3 0 0 3 3 3 0 Aspartyl protease tRNA_synt_2f PF02092.17 CDF36748.1 - 1.4e-161 539.1 0.0 1.8e-161 538.7 0.0 1.1 1 0 0 1 1 1 1 Glycyl-tRNA synthetase beta subunit tRNA-synt_2e PF02091.15 CDF36748.1 - 1.1e-112 375.9 0.0 1.6e-112 375.3 0.0 1.3 1 0 0 1 1 1 1 Glycyl-tRNA synthetase alpha subunit DALR_1 PF05746.15 CDF36748.1 - 0.0014 18.8 1.4 0.0064 16.7 0.8 2.5 1 1 1 2 2 2 1 DALR anticodon binding domain Med25_VWA PF11265.8 CDF36751.1 - 0.082 12.7 0.4 0.093 12.5 0.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A La PF05383.17 CDF36752.1 - 9e-13 48.1 0.0 1.6e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 La domain HMA PF00403.26 CDF36753.1 - 5.7e-44 148.4 13.7 1.9e-13 50.7 0.2 4.2 4 0 0 4 4 4 4 Heavy-metal-associated domain RRM_3 PF08777.11 CDF36753.1 - 0.0014 18.6 0.1 5.7 7.0 0.0 3.4 4 0 0 4 4 4 2 RNA binding motif YorP PF09629.10 CDF36753.1 - 0.0071 16.5 0.0 21 5.4 0.0 3.2 3 0 0 3 3 3 0 YorP protein DUF3247 PF11607.8 CDF36753.1 - 0.01 16.1 0.1 61 4.0 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3247) BON PF04972.17 CDF36753.1 - 0.014 15.6 0.6 58 4.1 0.0 3.7 3 0 0 3 3 3 0 BON domain DCA16 PF15349.6 CDF36753.1 - 0.031 13.9 0.1 10 5.6 0.0 2.6 3 0 0 3 3 3 0 DDB1- and CUL4-associated factor 16 DUF2491 PF10679.9 CDF36753.1 - 0.033 13.4 0.0 11 5.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2491) MM_CoA_mutase PF01642.22 CDF36753.1 - 0.035 12.7 0.7 0.054 12.1 0.7 1.3 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase HlyD_D4 PF16572.5 CDF36753.1 - 0.04 13.8 4.7 22 5.0 0.1 4.2 4 0 0 4 4 4 0 Long alpha hairpin domain of cation efflux system protein, CusB DUF1858 PF08984.11 CDF36753.1 - 0.059 13.5 5.6 21 5.4 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1858) LeuA_dimer PF08502.10 CDF36753.1 - 0.059 13.3 2.7 8.3 6.3 0.1 3.2 1 1 0 3 3 3 0 LeuA allosteric (dimerisation) domain TusA PF01206.17 CDF36753.1 - 0.23 11.3 2.2 57 3.6 0.1 4.0 3 1 1 4 4 4 0 Sulfurtransferase TusA Fer2_BFD PF04324.15 CDF36753.1 - 0.41 11.0 5.5 0.62 10.5 0.0 3.7 5 0 0 5 5 4 0 BFD-like [2Fe-2S] binding domain Elf1 PF05129.13 CDF36753.1 - 1 9.4 4.8 63 3.7 0.1 3.8 4 0 0 4 4 4 0 Transcription elongation factor Elf1 like E1-E2_ATPase PF00122.20 CDF36754.1 - 5.1e-47 159.7 0.3 1.1e-46 158.6 0.3 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CDF36754.1 - 8e-28 98.2 0.1 1.2e-27 97.6 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF36754.1 - 0.038 13.7 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Neurokinin_B PF03823.14 CDF36755.1 - 0.053 13.6 0.7 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 Neurokinin B DDE_Tnp_4 PF13359.6 CDF36756.1 - 5.3e-25 87.9 0.0 8.1e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CDF36756.1 - 0.026 14.2 0.0 0.17 11.5 0.0 1.9 1 1 1 2 2 2 0 Transposase DDE domain ABC_tran PF00005.27 CDF36759.1 - 3.2e-29 102.2 0.0 5.4e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDF36759.1 - 4.2e-18 66.0 19.6 1.2e-11 44.8 12.3 2.2 1 1 1 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CDF36759.1 - 0.00017 21.1 0.1 0.0034 16.8 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDF36759.1 - 0.044 14.2 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CDF36759.1 - 0.067 12.9 0.5 0.16 11.7 0.5 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDF36759.1 - 0.079 12.9 0.4 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 CDF36759.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDF36759.1 - 0.11 12.8 0.1 0.3 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 CDF36759.1 - 0.11 12.6 0.4 0.21 11.6 0.4 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_5 PF07728.14 CDF36759.1 - 0.17 11.9 0.4 4.3 7.3 0.4 2.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) tRNA-synt_His PF13393.6 CDF36760.1 - 1e-40 139.9 0.0 1.3e-40 139.6 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 CDF36760.1 - 3.7e-05 23.8 0.0 0.00011 22.3 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 CDF36760.1 - 0.00094 18.3 0.9 0.4 9.7 0.2 2.7 2 1 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CDF36760.1 - 0.026 14.0 0.1 0.053 13.0 0.0 1.5 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Acetyltransf_10 PF13673.7 CDF36761.1 - 1.7e-07 31.2 0.0 7.9e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF36761.1 - 3.4e-06 27.4 0.0 0.00024 21.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDF36761.1 - 0.12 12.6 0.1 0.37 11.0 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family rve PF00665.26 CDF36767.1 - 5.2e-07 29.9 0.1 3.4e-06 27.3 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Asp_protease PF09668.10 CDF36767.1 - 0.00021 21.1 0.0 0.00041 20.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease DUF1759 PF03564.15 CDF36767.1 - 0.00063 19.7 0.1 0.0015 18.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) RVT_2 PF07727.14 CDF36767.1 - 0.0068 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPPII PF12580.8 CDF36771.1 - 4.8e-38 130.5 0.0 8.1e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 Tripeptidyl peptidase II Peptidase_S8 PF00082.22 CDF36771.1 - 7.8e-37 127.1 0.1 1.4e-36 126.3 0.1 1.3 1 0 0 1 1 1 1 Subtilase family Radial_spoke_3 PF06098.11 CDF36772.1 - 0.1 11.9 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 RT_RNaseH PF17917.1 CDF36773.1 - 5.7e-23 81.2 0.1 1.8e-19 70.0 0.0 3.6 2 2 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF36773.1 - 2e-19 69.5 0.1 5.4e-18 64.9 0.0 2.7 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF36773.1 - 5.9e-18 65.2 0.0 1.3e-17 64.1 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF36773.1 - 8.4e-12 45.0 0.0 1.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF36773.1 - 0.00012 21.7 0.1 0.00023 20.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF36773.1 - 0.0014 18.3 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Proteasome PF00227.26 CDF36777.1 - 6.9e-60 201.8 0.0 8.5e-60 201.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF36777.1 - 5.3e-14 51.6 0.0 1.3e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature La PF05383.17 CDF36778.1 - 9.7e-15 54.4 0.0 1.6e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 La domain rve PF00665.26 CDF36780.1 - 8.9e-08 32.4 0.2 3.8e-07 30.3 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RVT_2 PF07727.14 CDF36780.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) NAD_binding_6 PF08030.12 CDF36781.1 - 0.017 15.3 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain DUF3530 PF12048.8 CDF36781.1 - 0.22 10.9 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) PAF PF15715.5 CDF36782.1 - 0.1 13.2 2.2 0.2 12.2 2.2 1.5 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Dynamin_N PF00350.23 CDF36783.1 - 2.1e-32 112.5 0.1 4.5e-32 111.4 0.1 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CDF36783.1 - 3.2e-27 95.5 0.5 4.7e-27 94.9 0.5 1.2 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 CDF36783.1 - 8.4e-07 29.1 0.7 1.1e-05 25.5 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase GED PF02212.18 CDF36783.1 - 2.4e-06 27.6 1.1 2e-05 24.6 0.1 2.6 2 1 0 2 2 2 1 Dynamin GTPase effector domain AAA_16 PF13191.6 CDF36783.1 - 0.0036 17.7 1.4 0.012 16.0 0.0 2.5 3 1 0 3 3 3 1 AAA ATPase domain SRPRB PF09439.10 CDF36783.1 - 0.014 14.8 0.0 2 7.8 0.0 2.5 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 CDF36783.1 - 0.036 14.3 0.3 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CDF36783.1 - 0.063 13.5 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Crl PF07417.12 CDF36783.1 - 0.092 12.8 0.1 0.29 11.2 0.1 1.9 1 1 0 1 1 1 0 Sigma factor-binding transcriptional regulator Crl RT_RNaseH PF17917.1 CDF36784.1 - 3.1e-34 117.4 0.1 4.5e-32 110.5 0.0 3.1 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF36784.1 - 6.1e-34 116.0 0.0 2.2e-33 114.3 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF36784.1 - 6.4e-20 71.5 0.0 1.2e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF36784.1 - 4.7e-13 49.0 0.0 8.8e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF36784.1 - 4.4e-10 39.5 0.0 6.8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo PF00385.24 CDF36784.1 - 5.8e-05 22.9 3.3 0.00017 21.5 0.5 2.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF36784.1 - 0.002 17.8 0.0 0.005 16.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDF36784.1 - 0.027 14.7 0.1 0.053 13.7 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger Pkinase PF00069.25 CDF36785.1 - 2.1e-68 230.6 0.0 3.5e-68 229.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36785.1 - 1.6e-31 109.5 0.0 2.1e-31 109.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF36785.1 - 1.9e-06 27.4 0.3 3.4e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF36785.1 - 6.5e-06 25.3 0.1 9.9e-06 24.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF36785.1 - 0.0013 18.1 0.0 0.012 14.9 0.0 2.3 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 CDF36785.1 - 0.012 15.5 0.1 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family bZIP_1 PF00170.21 CDF36786.1 - 0.11 12.6 10.4 0.29 11.3 10.4 1.7 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 CDF36786.1 - 0.93 9.6 17.2 0.25 11.4 13.7 1.9 1 1 1 2 2 2 0 Basic region leucine zipper Myb_DNA-binding PF00249.31 CDF36790.1 - 6.1e-11 42.3 0.2 1e-10 41.6 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF36790.1 - 0.017 15.0 0.2 0.032 14.1 0.2 1.4 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 CDF36790.1 - 0.043 14.1 0.1 0.086 13.1 0.1 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain AD PF09793.9 CDF36791.1 - 1.8e-16 60.1 0.0 2.3e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Anticodon-binding domain Vps51 PF08700.11 CDF36792.1 - 3.1e-08 33.6 0.3 1.3e-07 31.6 0.3 2.1 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 CDF36792.1 - 0.0026 16.5 0.2 0.0042 15.8 0.2 1.3 1 0 0 1 1 1 1 Dor1-like family DUF410 PF04190.13 CDF36792.1 - 0.064 13.1 0.0 0.24 11.2 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF410) Fes1 PF08609.10 CDF36793.1 - 1 10.3 6.8 2.7 8.9 6.3 2.2 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 Methyltransf_28 PF02636.17 CDF36794.1 - 8.1e-33 114.1 0.0 1.1e-32 113.7 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 CDF36794.1 - 0.033 14.9 0.0 0.073 13.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 CDF36794.1 - 0.085 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase 2-oxoacid_dh PF00198.23 CDF36795.1 - 1e-81 273.8 0.0 1.2e-81 273.6 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDF36795.1 - 5.9e-17 61.3 1.4 9.3e-17 60.6 1.4 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDF36795.1 - 0.00027 20.7 3.8 0.0026 17.6 0.2 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CDF36795.1 - 0.13 13.0 2.4 0.99 10.1 0.1 2.3 1 1 1 2 2 2 0 HlyD family secretion protein HlyD_D23 PF16576.5 CDF36795.1 - 0.22 10.7 2.0 0.53 9.5 0.2 2.2 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion HSP70 PF00012.20 CDF36796.1 - 3e-121 405.5 1.4 4.8e-121 404.8 1.4 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDF36796.1 - 6.6e-07 28.5 0.3 1.4e-06 27.4 0.3 1.5 1 0 0 1 1 1 1 MreB/Mbl protein IMS_HHH PF11798.8 CDF36796.1 - 0.0091 16.3 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif Med21 PF11221.8 CDF36796.1 - 0.018 15.3 0.6 0.018 15.3 0.6 2.3 2 0 0 2 2 2 0 Subunit 21 of Mediator complex FtsA PF14450.6 CDF36796.1 - 0.11 12.9 0.5 32 5.0 0.2 3.1 2 1 0 2 2 2 0 Cell division protein FtsA Rtt106 PF08512.12 CDF36798.1 - 1.2e-19 70.5 0.1 7.4e-17 61.5 0.1 2.4 2 0 0 2 2 2 2 Histone chaperone Rttp106-like POB3_N PF17292.2 CDF36798.1 - 7.6e-17 61.5 0.1 2.3e-15 56.8 0.1 2.5 2 0 0 2 2 2 1 POB3-like N-terminal PH domain SSrecog PF03531.14 CDF36798.1 - 2.5e-16 59.3 0.0 2.5e-15 56.2 0.0 2.5 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) DNA_pol_phi PF04931.13 CDF36798.1 - 10 4.1 10.0 14 3.6 10.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Rubis-subs-bind PF09273.11 CDF36799.1 - 1.4e-15 58.1 0.0 2.3e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding MFS_1 PF07690.16 CDF36800.1 - 7.4e-19 67.9 26.4 7.4e-19 67.9 26.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CDF36800.1 - 2.4e-07 29.9 11.9 4.8e-07 29.0 11.9 1.4 1 1 0 1 1 1 1 MFS_1 like family Pkinase_Tyr PF07714.17 CDF36802.1 - 6.2e-58 196.1 0.0 3.4e-54 183.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDF36802.1 - 4.1e-53 180.4 0.0 2.9e-50 171.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 CDF36802.1 - 0.0014 17.5 0.0 0.0025 16.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDF36802.1 - 0.012 15.0 1.4 0.015 14.6 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF36802.1 - 0.027 14.4 1.7 0.093 12.6 1.7 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 CDF36802.1 - 0.062 12.9 0.0 1.3 8.6 0.0 2.4 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 CDF36802.1 - 0.13 11.6 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like LPMO_10 PF03067.15 CDF36803.1 - 1.7e-15 58.2 1.1 3.3e-15 57.3 0.1 2.0 2 2 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Peptidase_C97 PF05903.14 CDF36805.1 - 6.4e-22 78.0 0.0 7.1e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain peroxidase PF00141.23 CDF36806.1 - 1.4e-46 159.1 0.0 2.1e-46 158.5 0.0 1.3 1 1 0 1 1 1 1 Peroxidase WD40 PF00400.32 CDF36807.1 - 1.9e-31 107.6 20.9 1.7e-06 28.6 0.2 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Utp13 PF08625.11 CDF36807.1 - 4e-16 59.2 0.1 1.4e-15 57.5 0.0 1.9 2 0 0 2 2 2 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 CDF36807.1 - 6.1e-06 26.4 1.7 2.9 8.2 0.1 5.3 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF36807.1 - 1.6e-05 23.8 0.9 2.1 6.9 0.1 5.5 4 2 1 6 6 6 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF36807.1 - 0.0048 15.9 0.5 2 7.3 0.1 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NIPSNAP PF07978.13 CDF36807.1 - 0.081 13.2 1.3 0.27 11.5 0.2 2.6 2 1 1 3 3 3 0 NIPSNAP Amino_oxidase PF01593.24 CDF36808.1 - 5.7e-14 52.2 0.0 1.6e-13 50.8 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF36808.1 - 6.9e-09 35.8 0.7 6.9e-09 35.8 0.7 2.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDF36808.1 - 0.0045 16.1 3.5 0.0086 15.2 3.2 1.7 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CDF36808.1 - 0.0052 16.0 0.2 0.012 14.9 0.2 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CDF36808.1 - 0.008 15.4 0.1 0.073 12.3 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDF36808.1 - 0.018 14.4 0.6 0.25 10.6 0.8 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase POTRA_1 PF08478.10 CDF36808.1 - 0.038 14.3 0.0 0.095 13.0 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, FtsQ-type Pkinase PF00069.25 CDF36810.1 - 8.8e-75 251.5 0.0 1.1e-74 251.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36810.1 - 1.6e-37 129.2 0.0 2.3e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF36810.1 - 0.00014 20.8 0.0 0.00026 19.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF36810.1 - 0.00045 19.6 0.0 0.0014 18.0 0.0 1.8 2 1 0 2 2 2 1 Kinase-like PH PF00169.29 CDF36810.1 - 0.015 15.8 0.0 0.033 14.7 0.0 1.6 1 0 0 1 1 1 0 PH domain CLASP_N PF12348.8 CDF36811.1 - 2.2e-09 37.2 0.0 3.9e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 CLASP N terminal ATG_C PF09333.11 CDF36811.1 - 0.06 13.7 0.1 0.36 11.2 0.1 2.4 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain MDMPI_N PF11716.8 CDF36811.1 - 5.2 7.8 8.1 2.7 8.7 4.1 2.6 2 1 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain SP_C-Propep PF08999.10 CDF36814.1 - 0.085 12.6 0.5 0.41 10.5 0.3 1.8 1 1 1 2 2 2 0 Surfactant protein C, N terminal propeptide NTP_transf_3 PF12804.7 CDF36815.1 - 1.9e-09 38.1 0.2 2.7e-09 37.6 0.2 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDF36815.1 - 2.5e-09 37.1 0.0 4.3e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 CDF36815.1 - 0.00016 21.3 11.8 0.00045 19.8 2.0 3.1 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 CDF36815.1 - 0.08 11.1 2.9 0.18 9.9 2.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 CDF36815.1 - 0.13 11.1 0.3 0.25 10.2 0.3 1.4 1 0 0 1 1 1 0 L-fucokinase PIF1 PF05970.14 CDF36818.1 - 1.1e-88 297.9 0.0 3e-61 207.6 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CDF36818.1 - 2.4e-11 43.7 0.0 3.9e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain UCR_Fe-S_N PF10399.9 CDF36818.1 - 0.12 11.7 0.4 0.26 10.7 0.4 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal AAA_19 PF13245.6 CDF36818.1 - 0.13 12.6 0.0 0.35 11.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Transket_pyr PF02779.24 CDF36820.1 - 4.4e-38 130.7 0.0 6.1e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CDF36820.1 - 1.5e-23 83.4 0.1 8.1e-23 81.0 0.0 2.2 3 0 0 3 3 3 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 CDF36820.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain Pkinase_Tyr PF07714.17 CDF36823.1 - 5.5e-29 101.2 0.0 1.4e-15 57.3 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDF36823.1 - 1e-27 97.2 0.0 5.9e-13 48.8 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Gaa1 PF04114.14 CDF36824.1 - 0.037 13.0 0.2 0.048 12.7 0.2 1.1 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component PDZ PF00595.24 CDF36827.1 - 0.0066 16.8 0.1 0.017 15.5 0.1 1.7 1 0 0 1 1 1 1 PDZ domain Peptidase_M20 PF01546.28 CDF36828.1 - 6.8e-23 81.5 0.0 1.2e-22 80.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 CDF36828.1 - 6.1e-14 52.2 8.7 0.062 14.2 0.3 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat M20_dimer PF07687.14 CDF36828.1 - 3.6e-12 46.2 0.0 8.1e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain PQQ_3 PF13570.6 CDF36828.1 - 0.062 13.8 1.0 82 3.9 0.0 4.6 5 0 0 5 5 5 0 PQQ-like domain DUF3678 PF12435.8 CDF36828.1 - 0.19 11.1 2.4 0.21 11.0 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) MAGE PF01454.19 CDF36830.1 - 7.5e-31 107.5 0.0 1e-30 107.0 0.0 1.2 1 0 0 1 1 1 1 MAGE family IATP PF04568.12 CDF36832.1 - 5.2e-06 26.8 0.2 5.9e-06 26.6 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Urb2 PF10441.9 CDF36832.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.1 1 0 0 1 1 1 0 Urb2/Npa2 family Clat_adaptor_s PF01217.20 CDF36834.1 - 7.9e-48 162.0 0.5 9.2e-48 161.8 0.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SBF PF01758.16 CDF36835.1 - 8.2e-36 123.5 15.3 8.2e-36 123.5 15.3 1.7 2 0 0 2 2 2 1 Sodium Bile acid symporter family APH PF01636.23 CDF36840.1 - 5.7e-07 29.7 0.1 8.9e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Beta-TrCP_D PF12125.8 CDF36840.1 - 0.12 12.3 0.4 0.8 9.6 0.0 2.3 2 0 0 2 2 2 0 D domain of beta-TrCP DDE_Tnp_4 PF13359.6 CDF36841.1 - 2.7e-08 33.7 0.0 4.2e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Auxin_inducible PF02519.14 CDF36841.1 - 0.035 14.3 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 Auxin responsive protein GCFC PF07842.12 CDF36842.1 - 3.5e-18 66.2 0.1 5.6e-18 65.5 0.1 1.3 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 CDF36842.1 - 0.00032 20.5 2.2 0.00051 19.9 0.1 2.4 2 0 0 2 2 2 1 G-patch domain Gon7 PF08738.10 CDF36842.1 - 0.1 12.7 0.4 0.86 9.7 0.2 2.2 2 0 0 2 2 2 0 Gon7 family RtcB PF01139.17 CDF36843.1 - 1e-148 495.9 0.3 1.2e-148 495.7 0.3 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Oxidored_FMN PF00724.20 CDF36844.1 - 5.8e-73 246.1 0.0 7e-73 245.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CDF36844.1 - 0.0022 17.2 0.0 0.0084 15.2 0.0 1.9 3 0 0 3 3 3 1 Dihydrouridine synthase (Dus) PAP2 PF01569.21 CDF36845.1 - 0.07 12.9 0.1 0.21 11.4 0.1 1.7 1 1 0 1 1 1 0 PAP2 superfamily PAP2 PF01569.21 CDF36848.1 - 0.078 12.8 0.1 0.32 10.8 0.1 1.9 1 1 0 1 1 1 0 PAP2 superfamily Oxidored_FMN PF00724.20 CDF36851.1 - 4.7e-12 45.8 0.0 6.2e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CDF36851.1 - 0.0022 17.1 0.0 0.003 16.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Oxidored_FMN PF00724.20 CDF36852.1 - 8.5e-10 38.4 0.0 1.1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CDF36852.1 - 0.0036 16.5 0.0 0.0046 16.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) PAP2 PF01569.21 CDF36853.1 - 0.048 13.4 0.1 0.14 12.0 0.1 1.7 1 1 0 1 1 1 0 PAP2 superfamily UQ_con PF00179.26 CDF36856.1 - 9.9e-50 167.8 0.0 1.1e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PRK PF00485.18 CDF36858.1 - 7.2e-65 218.4 0.0 9.6e-65 218.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family KAP_NTPase PF07693.14 CDF36858.1 - 0.0069 15.7 0.0 0.0097 15.2 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain AAA_18 PF13238.6 CDF36858.1 - 0.055 14.0 0.0 0.17 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDF36858.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Zeta_toxin PF06414.12 CDF36858.1 - 0.17 11.1 0.1 0.55 9.5 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin Kunitz_BPTI PF00014.23 CDF36859.1 - 9.4e-27 93.0 13.8 8.3e-14 51.6 2.9 2.2 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain zf_CCCH_5 PF18384.1 CDF36859.1 - 0.66 10.1 0.2 0.66 10.1 0.2 2.9 3 1 0 3 3 3 0 Unkempt Zinc finger domain 1 (Znf1) Kunitz_BPTI PF00014.23 CDF36860.1 - 4.5e-26 90.8 7.1 7.5e-14 51.7 1.4 2.2 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain HECT PF00632.25 CDF36861.1 - 1.4e-90 303.9 0.0 2.1e-90 303.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 CDF36861.1 - 3.8e-15 54.7 12.4 9.7e-06 24.9 0.3 3.7 3 0 0 3 3 3 3 Ubiquitin binding region UNC45-central PF11701.8 CDF36861.1 - 0.09 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central DDHD PF02862.17 CDF36861.1 - 0.46 10.6 7.0 4.6 7.3 1.2 2.9 3 0 0 3 3 3 0 DDHD domain PMC2NT PF08066.12 CDF36861.1 - 9.5 7.0 7.9 2.5 8.8 0.2 3.5 3 0 0 3 3 3 0 PMC2NT (NUC016) domain zf-C2H2 PF00096.26 CDF36864.1 - 0.0017 18.7 13.9 0.0042 17.5 4.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF36864.1 - 0.0022 18.3 0.4 0.0022 18.3 0.4 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF36864.1 - 0.2 12.6 13.3 0.25 12.3 3.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Met_synt_B12 PF02965.17 CDF36865.1 - 1.9e-110 368.6 0.8 4.2e-110 367.5 0.2 1.8 2 0 0 2 2 2 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 CDF36865.1 - 7.6e-74 248.9 0.0 1.4e-73 248.0 0.0 1.5 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 CDF36865.1 - 7.6e-55 186.2 0.1 3.6e-54 184.0 0.1 2.1 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 CDF36865.1 - 7.5e-25 87.2 0.3 2.9e-24 85.3 0.3 2.2 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 CDF36865.1 - 2.7e-21 75.8 0.4 2.2e-20 72.9 0.3 2.6 2 1 1 3 3 3 1 B12 binding domain Spt20 PF12090.8 CDF36868.1 - 0.074 12.7 1.6 0.082 12.5 1.6 1.0 1 0 0 1 1 1 0 Spt20 family PAF PF15715.5 CDF36870.1 - 0.12 12.9 1.4 0.12 13.0 1.4 1.2 1 1 0 1 1 1 0 PCNA-associated factor histone like domain Y_phosphatase3 PF13350.6 CDF36871.1 - 8.4e-08 32.5 0.0 2.2e-07 31.1 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 CDF36871.1 - 2.5e-07 30.4 0.0 1.3e-06 28.1 0.0 2.0 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDF36871.1 - 3.4e-07 30.1 0.0 7.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDF36871.1 - 2.6e-05 23.9 0.0 0.00014 21.5 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CDF36871.1 - 6.5e-05 23.1 0.0 0.00012 22.2 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate UQ_con PF00179.26 CDF36872.1 - 2.4e-18 66.1 0.0 3.9e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDF36872.1 - 0.064 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 RWD domain Pkinase PF00069.25 CDF36873.1 - 5.6e-59 199.6 0.0 7e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36873.1 - 6.1e-31 107.6 0.0 7.8e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF36873.1 - 1.4e-09 37.7 0.0 3.1e-09 36.6 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDF36873.1 - 0.0035 16.2 0.0 0.0051 15.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF36873.1 - 0.052 13.5 0.0 0.14 12.0 0.0 1.5 1 1 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CDF36873.1 - 0.085 11.9 0.1 0.32 10.0 0.1 1.8 1 1 1 2 2 2 0 Seadornavirus VP7 PCI PF01399.27 CDF36875.1 - 2.1e-13 50.7 0.2 7.8e-13 48.9 0.1 2.0 2 0 0 2 2 2 1 PCI domain DEAD PF00270.29 CDF36876.1 - 4e-50 170.0 0.0 8.9e-50 168.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF36876.1 - 8.3e-28 97.0 0.0 2.2e-27 95.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF36876.1 - 0.00018 21.5 0.0 0.00043 20.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Voldacs PF03517.13 CDF36876.1 - 0.0095 16.1 1.6 3.2 7.9 0.2 2.6 2 0 0 2 2 2 2 Regulator of volume decrease after cellular swelling Helicase_C_2 PF13307.6 CDF36878.1 - 7.5e-51 172.7 0.0 1.5e-50 171.7 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDF36878.1 - 1.1e-40 139.1 0.0 2e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 CDF36878.1 - 2.9e-05 24.2 0.0 0.017 15.1 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF36878.1 - 0.00017 21.4 0.0 0.0053 16.6 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase HBB PF06777.11 CDF36878.1 - 0.026 14.2 0.1 0.073 12.7 0.0 1.7 2 0 0 2 2 2 0 Helical and beta-bridge domain AAA_22 PF13401.6 CDF36878.1 - 0.12 12.7 0.0 4.6 7.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain Abhydrolase_1 PF00561.20 CDF36879.1 - 0.00054 19.7 0.1 0.003 17.3 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF36879.1 - 0.01 15.1 0.0 0.025 13.9 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 CUE PF02845.16 CDF36879.1 - 0.031 14.0 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 CUE domain Phage_Gp23 PF10669.9 CDF36879.1 - 0.4 11.0 1.7 0.74 10.1 1.7 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Med30 PF11315.8 CDF36880.1 - 9.3e-06 25.9 2.9 1.9e-05 24.9 2.9 1.5 1 0 0 1 1 1 1 Mediator complex subunit 30 Med21 PF11221.8 CDF36880.1 - 0.0089 16.3 10.0 0.55 10.5 1.4 2.4 1 1 1 2 2 2 2 Subunit 21 of Mediator complex TUTF7_u4 PF16631.5 CDF36880.1 - 0.024 15.2 2.0 0.05 14.2 2.0 1.5 1 0 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 Mu-like_Pro PF10123.9 CDF36880.1 - 0.04 13.5 6.8 0.045 13.3 6.8 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein DDE_Tnp_1_6 PF13751.6 CDF36880.1 - 0.086 13.1 1.6 0.14 12.4 1.6 1.3 1 0 0 1 1 1 0 Transposase DDE domain Seryl_tRNA_N PF02403.22 CDF36880.1 - 0.41 10.9 9.4 0.1 12.8 5.8 1.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CDH1_2_SANT_HL1 PF18375.1 CDF36880.1 - 0.45 11.2 4.6 2.3 8.9 2.2 2.1 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Atg14 PF10186.9 CDF36880.1 - 0.8 8.7 6.6 0.99 8.4 6.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lactamase_B_2 PF12706.7 CDF36881.1 - 6.6e-18 65.0 0.0 1.7e-14 53.8 0.0 3.0 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 CDF36881.1 - 4e-14 52.0 0.0 1e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.27 CDF36881.1 - 7.6e-06 26.1 0.0 2.7e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RtcB PF01139.17 CDF36882.1 - 1.2e-24 87.3 0.0 1.3e-24 87.2 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB RtcB PF01139.17 CDF36883.1 - 4.9e-34 118.2 1.7 5.5e-34 118.0 1.7 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Cu-oxidase_4 PF02578.15 CDF36883.1 - 0.00035 20.2 1.1 0.00049 19.8 1.1 1.3 1 1 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase RICTOR_V PF14668.6 CDF36884.1 - 0.017 15.4 0.2 0.31 11.3 0.0 2.6 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 DRY_EERY PF09750.9 CDF36884.1 - 0.13 12.5 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 Alternative splicing regulator Ribosom_S12_S23 PF00164.25 CDF36885.1 - 1.5e-49 166.4 0.2 1.8e-49 166.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_L6e PF01159.19 CDF36886.1 - 8.4e-33 113.2 0.5 1.1e-32 112.8 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Uso1_p115_head PF04869.14 CDF36887.1 - 3.8e-14 52.5 0.0 7.4e-13 48.3 0.0 3.2 3 1 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 CDF36887.1 - 0.0014 19.0 9.2 0.0014 19.0 9.2 18.6 7 5 10 17 17 17 2 Uso1 / p115 like vesicle tethering protein, C terminal region DHR10 PF18595.1 CDF36887.1 - 0.002 18.2 13.2 0.002 18.2 13.2 18.7 8 3 11 20 20 20 4 Designed helical repeat protein 10 domain Myb_DNA-binding PF00249.31 CDF36888.1 - 9.6e-10 38.5 0.1 3e-09 36.9 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF36888.1 - 0.08 13.2 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF36888.1 - 0.1 12.5 0.3 0.21 11.5 0.3 1.4 1 0 0 1 1 1 0 Myb DNA-binding like SET PF00856.28 CDF36889.1 - 3.3e-21 76.4 1.2 2.7e-20 73.4 0.5 2.7 2 1 0 2 2 2 1 SET domain FYRN PF05964.14 CDF36889.1 - 2.3e-13 49.7 0.0 5.8e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-HC5HC2H PF13771.6 CDF36889.1 - 2.3e-09 37.4 1.0 2.3e-09 37.4 1.0 7.5 4 1 3 7 7 7 3 PHD-like zinc-binding domain FYRC PF05965.14 CDF36889.1 - 3.1e-09 36.8 0.0 6.4e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus PHD PF00628.29 CDF36889.1 - 7.6e-09 35.3 39.4 3.5e-07 30.0 6.0 8.3 8 2 0 8 8 8 4 PHD-finger Nop14 PF04147.12 CDF36891.1 - 6e-60 203.5 16.9 9e-59 199.6 16.9 2.6 1 1 0 1 1 1 1 Nop14-like family ATP-synt_Eps PF04627.13 CDF36891.1 - 0.024 14.6 2.8 3.1 7.9 0.1 2.9 2 0 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain ANAPC4_WD40 PF12894.7 CDF36893.1 - 0.012 15.9 0.0 0.045 14.1 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain NUP214 PF16755.5 CDF36893.1 - 0.24 10.6 0.2 0.41 9.8 0.2 1.3 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Trypsin_2 PF13365.6 CDF36894.1 - 1.2e-33 117.1 1.8 2.5e-33 116.1 1.8 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 CDF36894.1 - 4.4e-15 55.8 0.8 1.2e-14 54.3 0.4 2.0 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 CDF36894.1 - 1.8e-12 47.6 0.1 3.7e-12 46.5 0.1 1.5 1 1 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 CDF36894.1 - 2.1e-11 43.5 0.9 1.1e-09 38.0 0.5 2.6 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDF36894.1 - 3e-09 37.1 2.1 5.4e-08 33.1 0.7 2.5 2 0 0 2 2 2 1 PDZ domain LSM PF01423.22 CDF36894.1 - 0.0035 17.0 0.0 0.0074 15.9 0.0 1.5 1 0 0 1 1 1 1 LSM domain Peptidase_S46 PF10459.9 CDF36894.1 - 0.014 14.1 0.1 1 7.9 0.0 2.1 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S7 PF00949.21 CDF36894.1 - 0.014 15.2 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S29 PF02907.15 CDF36894.1 - 0.018 14.8 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Tricorn_PDZ PF14685.6 CDF36894.1 - 0.018 15.0 0.7 0.067 13.2 0.1 2.3 2 1 0 2 2 2 0 Tricorn protease PDZ domain GRASP55_65 PF04495.14 CDF36894.1 - 0.035 14.4 0.0 0.071 13.4 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Hfq PF17209.3 CDF36894.1 - 0.16 11.7 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Hfq protein DUF31 PF01732.16 CDF36894.1 - 0.38 10.2 3.5 2.6 7.5 0.1 2.8 3 0 0 3 3 3 0 Putative peptidase (DUF31) HupF_HypC PF01455.18 CDF36894.1 - 0.66 10.2 2.0 1 9.5 0.3 2.2 2 0 0 2 2 2 0 HupF/HypC family TPR_1 PF00515.28 CDF36896.1 - 1e-26 91.6 25.1 2.6e-07 30.2 0.1 8.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDF36896.1 - 8.3e-23 78.6 17.6 0.00014 21.8 0.0 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDF36896.1 - 2.7e-20 71.3 31.2 0.00011 22.7 0.1 8.8 6 4 3 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 CDF36896.1 - 5.7e-20 70.7 11.6 2.4e-08 33.5 0.0 5.5 4 2 2 6 6 6 4 TPR repeat TPR_2 PF07719.17 CDF36896.1 - 9.3e-18 62.9 33.0 0.0002 21.2 0.1 9.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 CDF36896.1 - 1.5e-16 60.7 20.7 3.5e-05 24.2 0.2 6.6 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDF36896.1 - 2e-16 59.1 12.1 0.0032 17.7 0.0 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF36896.1 - 3.7e-12 46.7 21.8 5.1e-06 27.0 0.1 6.6 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF36896.1 - 3.2e-10 40.2 28.1 0.0017 18.6 0.3 7.4 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 CDF36896.1 - 1.1e-05 24.8 12.2 0.0055 16.0 0.6 4.5 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDF36896.1 - 3.1e-05 23.7 24.4 0.0057 16.5 0.1 6.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDF36896.1 - 9.4e-05 22.8 29.5 2.6 8.9 0.0 8.7 11 0 0 11 11 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDF36896.1 - 0.00012 21.9 4.2 0.0017 18.3 1.0 7.4 9 1 0 9 9 8 2 Tetratricopeptide repeat ChAPs PF09295.10 CDF36896.1 - 0.0029 16.6 0.0 0.022 13.7 0.0 2.2 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.6 CDF36896.1 - 0.0036 17.4 13.7 2.1 8.6 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF3856 PF12968.7 CDF36896.1 - 0.0042 17.2 1.9 3 7.9 0.0 3.5 3 0 0 3 3 3 1 Domain of Unknown Function (DUF3856) ANAPC8 PF04049.13 CDF36896.1 - 0.043 13.9 0.1 0.043 13.9 0.1 2.6 3 1 0 3 3 3 0 Anaphase promoting complex subunit 8 / Cdc23 ANAPC3 PF12895.7 CDF36896.1 - 0.21 11.9 19.2 0.71 10.1 0.1 5.1 4 2 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 CDF36896.1 - 1.4 8.6 10.5 2.4 7.8 0.6 3.9 5 1 1 6 6 6 0 26S proteasome subunit RPN7 Tubulin PF00091.25 CDF36897.1 - 2.2e-66 223.8 0.0 3.3e-66 223.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDF36897.1 - 1.3e-40 138.5 0.1 2e-40 137.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDF36897.1 - 0.0031 17.2 0.0 0.009 15.7 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 CDF36897.1 - 0.089 12.0 0.3 0.17 11.1 0.3 1.3 1 0 0 1 1 1 0 Tubulin like MMR_HSR1 PF01926.23 CDF36898.1 - 2.4e-10 40.5 0.0 5.7e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF36898.1 - 9e-09 35.0 0.0 1.5e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 CDF36898.1 - 7.7e-06 25.4 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AIG1 PF04548.16 CDF36898.1 - 1.6e-05 24.4 0.0 3.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_23 PF13476.6 CDF36898.1 - 0.00049 20.6 0.0 0.00084 19.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDF36898.1 - 0.00062 19.7 0.6 0.0028 17.6 0.6 1.9 1 1 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 CDF36898.1 - 0.0012 19.4 0.0 0.003 18.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CDF36898.1 - 0.0013 18.4 0.0 0.0038 16.9 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 CDF36898.1 - 0.0077 16.3 0.5 1.1 9.3 0.1 2.4 1 1 1 2 2 2 1 Dynamin family AAA_21 PF13304.6 CDF36898.1 - 0.012 15.5 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 CDF36898.1 - 0.018 15.3 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ploopntkinase3 PF18751.1 CDF36898.1 - 0.021 14.8 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 CDF36898.1 - 0.034 14.5 0.2 0.099 13.0 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CDF36898.1 - 0.048 13.9 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 CDF36898.1 - 0.13 12.0 0.1 0.4 10.4 0.1 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 CDF36898.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain CBM46 PF18448.1 CDF36898.1 - 0.15 12.4 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain C2 PF00168.30 CDF36900.1 - 3.5e-08 33.6 0.0 7.7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain PI3K_C2 PF00792.24 CDF36900.1 - 0.043 13.7 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 PCI PF01399.27 CDF36901.1 - 5.2e-10 39.8 0.0 1.3e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 PCI domain FAA_hydrolase PF01557.18 CDF36902.1 - 1.2e-56 191.9 0.0 1.6e-56 191.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CDF36902.1 - 3.4e-18 65.8 0.0 5.6e-17 61.9 0.1 2.4 2 1 0 2 2 2 1 Fumarylacetoacetase N-terminal Tim17 PF02466.19 CDF36903.1 - 3.5e-16 59.5 12.4 5.2e-16 59.0 12.4 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ABC_membrane_2 PF06472.15 CDF36904.1 - 2.6e-87 292.7 0.1 3.3e-87 292.3 0.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDF36904.1 - 1.6e-17 64.3 0.0 3.6e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF36904.1 - 0.0022 17.9 0.0 0.0042 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDF36904.1 - 0.0083 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDF36904.1 - 0.018 15.6 0.0 0.057 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDF36904.1 - 0.069 12.9 0.0 4.4 7.0 0.0 2.7 2 1 1 3 3 3 0 AAA domain SMC_N PF02463.19 CDF36904.1 - 0.17 11.3 0.0 0.59 9.5 0.0 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF3824 PF12868.7 CDF36904.1 - 0.36 11.5 2.2 0.57 10.8 2.2 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) CPSase_L_D2 PF02786.17 CDF36905.1 - 2.3e-114 380.2 0.1 8.3e-82 273.8 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain OTCace_N PF02729.21 CDF36905.1 - 2.5e-49 167.1 0.0 5.6e-49 166.0 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 CDF36905.1 - 3.4e-40 137.8 0.0 7.3e-40 136.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 CDF36905.1 - 3.9e-36 124.1 0.0 8.7e-36 123.0 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain PF00988.22 CDF36905.1 - 6.7e-34 116.5 0.0 3.8e-33 114.0 0.0 2.4 3 0 0 3 3 3 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace PF00185.24 CDF36905.1 - 2.4e-32 112.2 0.0 4.5e-32 111.3 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Dala_Dala_lig_C PF07478.13 CDF36905.1 - 4.5e-18 65.5 0.1 7e-09 35.5 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 CDF36905.1 - 7.9e-18 64.4 0.0 3e-17 62.6 0.0 2.1 1 0 0 1 1 1 1 MGS-like domain ATP-grasp PF02222.22 CDF36905.1 - 1e-14 54.5 0.1 2.1e-07 30.7 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CDF36905.1 - 5.7e-14 52.0 0.1 4.2e-08 33.0 0.0 3.0 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 CDF36905.1 - 4.6e-06 26.8 0.2 0.0033 17.5 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 CDF36905.1 - 0.00031 20.6 0.2 0.012 15.4 0.2 2.4 1 1 0 1 1 1 1 Peptidase C26 TrkA_N PF02254.18 CDF36905.1 - 0.0087 16.3 0.0 1.8 8.9 0.0 3.0 2 0 0 2 2 2 1 TrkA-N domain Peripla_BP_6 PF13458.6 CDF36905.1 - 0.021 14.5 0.3 11 5.6 0.1 3.7 4 0 0 4 4 4 0 Periplasmic binding protein RRM_1 PF00076.22 CDF36906.1 - 4.1e-34 116.2 0.0 7.4e-16 57.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF36906.1 - 2.6e-09 37.1 0.1 0.00021 21.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDF36906.1 - 0.00035 20.5 0.1 0.27 11.3 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif TFIIA PF03153.13 CDF36906.1 - 0.13 12.3 18.0 0.015 15.3 11.2 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit OB_RNB PF08206.11 CDF36906.1 - 0.88 9.3 3.3 8.9 6.1 0.3 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain Frag1 PF10277.9 CDF36907.1 - 2.4e-08 33.8 11.8 3.7e-08 33.2 11.8 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Histone PF00125.24 CDF36908.1 - 0.069 13.5 3.9 0.081 13.3 3.9 1.1 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDF36908.1 - 0.24 12.0 5.0 0.17 12.5 3.9 1.4 1 1 0 1 1 1 0 PCNA-associated factor histone like domain Ribosomal_S21 PF01165.20 CDF36909.1 - 2.6e-19 68.7 4.8 2.6e-19 68.7 4.8 1.7 1 1 1 2 2 2 1 Ribosomal protein S21 DUF4220 PF13968.6 CDF36909.1 - 0.2 11.0 0.1 0.18 11.1 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) PPR_2 PF13041.6 CDF36910.1 - 1.6e-23 82.6 2.5 1.7e-10 40.9 0.1 5.4 5 2 2 7 7 7 4 PPR repeat family PPR_3 PF13812.6 CDF36910.1 - 2.9e-22 78.5 0.0 1e-07 31.9 0.0 5.8 3 2 3 6 6 6 6 Pentatricopeptide repeat domain PPR PF01535.20 CDF36910.1 - 2.2e-21 74.5 2.0 0.001 19.2 0.0 8.0 8 0 0 8 8 8 5 PPR repeat PPR_long PF17177.4 CDF36910.1 - 1.1e-10 41.2 0.0 0.004 16.5 0.0 3.2 3 0 0 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 CDF36910.1 - 3.2e-09 36.3 0.6 0.00096 18.8 0.0 5.5 6 0 0 6 6 6 2 PPR repeat Calx-beta PF03160.14 CDF36910.1 - 0.083 13.1 1.2 0.2 11.8 1.2 1.6 1 0 0 1 1 1 0 Calx-beta domain Ribosomal_L27A PF00828.19 CDF36911.1 - 2.3e-24 86.5 0.0 3.5e-24 85.9 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RTC4 PF14474.6 CDF36911.1 - 0.088 13.0 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 RTC4-like domain DHquinase_II PF01220.19 CDF36912.1 - 0.032 13.9 1.0 0.032 13.9 1.0 2.4 3 0 0 3 3 3 0 Dehydroquinase class II CBP_BcsQ PF06564.12 CDF36912.1 - 0.05 13.1 0.6 0.11 11.9 0.6 1.6 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ SET PF00856.28 CDF36913.1 - 4.5e-18 66.2 0.0 1.6e-17 64.4 0.0 2.1 1 0 0 1 1 1 1 SET domain AWS PF17907.1 CDF36913.1 - 1.2e-06 28.4 6.9 2.3e-06 27.5 6.9 1.5 1 0 0 1 1 1 1 AWS domain Nucleoporin2 PF04096.14 CDF36914.1 - 3.2e-29 102.0 0.0 4.9e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CDF36914.1 - 0.00077 20.3 36.0 0.00077 20.3 36.0 6.5 1 1 2 3 3 3 1 Nucleoporin FG repeat region INT_SG_DDX_CT_C PF15300.6 CDF36914.1 - 0.059 13.2 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus ORC6 PF05460.13 CDF36914.1 - 0.8 8.9 8.3 1.4 8.1 8.3 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Tnp_DNA_bind PF14706.6 CDF36915.1 - 0.048 13.5 0.4 0.1 12.5 0.4 1.5 1 0 0 1 1 1 0 Transposase DNA-binding Arf PF00025.21 CDF36916.1 - 3.1e-36 124.4 0.1 4.4e-36 123.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDF36916.1 - 3.4e-12 46.6 0.1 4.9e-12 46.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDF36916.1 - 1.8e-07 30.8 0.0 2.5e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CDF36916.1 - 5.5e-07 29.3 0.1 7.5e-07 28.9 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CDF36916.1 - 6.5e-06 25.5 0.5 0.0019 17.4 0.1 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 CDF36916.1 - 8.6e-06 25.3 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDF36916.1 - 0.0063 16.6 0.0 0.009 16.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF36916.1 - 0.073 12.6 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B Tubulin PF00091.25 CDF36917.1 - 7.2e-69 231.9 0.0 1.2e-68 231.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDF36917.1 - 5.6e-45 152.6 0.0 1.8e-44 151.0 0.0 1.8 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CDF36917.1 - 4.6e-06 26.9 0.1 1.8e-05 25.0 0.1 2.0 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 CDF36917.1 - 0.067 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Arf PF00025.21 CDF36918.1 - 8e-67 224.1 0.1 9.7e-67 223.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDF36918.1 - 2.6e-15 56.7 0.0 3.6e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDF36918.1 - 8e-13 48.3 0.0 9e-13 48.1 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDF36918.1 - 3.6e-11 42.8 0.0 4.6e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDF36918.1 - 4.8e-08 32.6 0.0 5.5e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CDF36918.1 - 8e-07 28.5 0.6 0.00042 19.6 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CDF36918.1 - 9.4e-05 22.5 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 CDF36918.1 - 0.00072 18.6 0.3 0.012 14.6 0.2 2.5 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 CDF36918.1 - 0.00077 19.0 0.1 0.0012 18.4 0.1 1.3 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_33 PF13671.6 CDF36918.1 - 0.16 12.1 0.1 0.29 11.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain SF3A2 PF16835.5 CDF36919.1 - 6.5e-36 122.6 0.0 1e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) CactinC_cactus PF09732.9 CDF36919.1 - 5e-05 23.2 0.6 7.6e-05 22.6 0.6 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein zf-met PF12874.7 CDF36919.1 - 0.00011 22.5 0.3 0.00022 21.5 0.3 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PMI_typeI PF01238.21 CDF36920.1 - 5.7e-92 308.8 0.0 9e-92 308.1 0.0 1.3 1 0 0 1 1 1 1 Phosphomannose isomerase type I CNOT11 PF10155.9 CDF36922.1 - 4.9e-42 143.0 2.0 8.1e-42 142.3 2.0 1.4 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 CNOT11 PF10155.9 CDF36924.1 - 2.6e-42 143.9 2.1 4.4e-42 143.2 2.1 1.4 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Pep3_Vps18 PF05131.14 CDF36925.1 - 1.5e-11 44.3 0.0 7.4e-05 22.6 0.0 2.7 2 0 0 2 2 2 2 Pep3/Vps18/deep orange family DUF3176 PF11374.8 CDF36925.1 - 0.073 13.3 0.2 1.6 9.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3176) DUF4487 PF14868.6 CDF36925.1 - 0.11 11.3 0.9 0.39 9.5 0.3 1.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4487) PQQ_3 PF13570.6 CDF36925.1 - 0.4 11.2 2.7 0.59 10.7 0.1 2.7 3 0 0 3 3 3 0 PQQ-like domain UQ_con PF00179.26 CDF36926.1 - 4.3e-47 159.3 0.0 4.9e-47 159.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF36926.1 - 4.3e-05 23.2 0.0 5.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CDF36926.1 - 0.019 14.8 0.0 0.046 13.6 0.0 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 CDF36926.1 - 0.11 12.8 0.1 0.15 12.4 0.1 1.4 1 1 0 1 1 1 0 RWD domain DUF2713 PF10897.8 CDF36928.1 - 0.0093 15.7 0.0 0.023 14.3 0.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2713) Ribosomal_S9 PF00380.19 CDF36929.1 - 2.9e-32 111.7 0.1 3.4e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Cupin_2 PF07883.11 CDF36931.1 - 4.2e-08 32.8 0.8 8.3e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CDF36931.1 - 9.3e-05 22.0 0.0 0.00052 19.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Pirin_C PF05726.13 CDF36931.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Pirin C-terminal cupin domain Pkinase PF00069.25 CDF36932.1 - 4.8e-61 206.4 0.0 6.3e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF36932.1 - 2.1e-31 109.2 0.0 2.6e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF36932.1 - 7.8e-06 24.9 0.0 1.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF36932.1 - 1.1e-05 25.5 1.1 0.00025 21.0 0.2 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF36932.1 - 1.5e-05 24.5 0.1 0.0041 16.5 0.0 2.3 2 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 CDF36932.1 - 0.00018 20.6 0.0 0.00047 19.2 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CDF36932.1 - 0.00027 20.3 0.2 0.00056 19.3 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CDF36932.1 - 0.012 14.7 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 CDF36932.1 - 0.21 11.2 0.8 4.9 6.7 0.0 2.9 2 1 1 3 3 3 0 RIO1 family Amidohydro_1 PF01979.20 CDF36936.1 - 1.8e-66 224.8 3.0 2.4e-66 224.4 3.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDF36936.1 - 3.1e-18 66.5 0.2 2.1e-14 53.9 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 CDF36936.1 - 8.7e-06 25.3 0.0 1.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase 3-HAO PF06052.12 CDF36937.1 - 1.1e-36 125.8 0.0 1.3e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 CDF36937.1 - 6.4e-05 22.6 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Cupin domain VWA PF00092.28 CDF36939.1 - 5.4e-23 82.1 0.0 8.5e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CDF36939.1 - 6e-16 59.0 0.4 2.7e-15 56.9 0.2 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain F-box-like PF12937.7 CDF36939.1 - 8.4e-05 22.4 1.0 0.00023 21.0 1.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDF36939.1 - 0.00015 21.6 0.9 0.00033 20.4 0.9 1.7 1 0 0 1 1 1 1 F-box domain DUF2201 PF09967.9 CDF36939.1 - 0.49 10.5 5.7 0.18 11.9 0.2 2.7 3 0 0 3 3 3 0 VWA-like domain (DUF2201) DHR10 PF18595.1 CDF36944.1 - 4.5e-08 33.2 4.9 4.5e-08 33.2 4.9 2.3 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain TMCO5 PF14992.6 CDF36944.1 - 0.011 15.4 8.4 0.014 15.0 8.4 1.2 1 0 0 1 1 1 0 TMCO5 family CREPT PF16566.5 CDF36944.1 - 0.037 14.2 1.0 0.037 14.2 1.0 2.3 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Snapin_Pallidin PF14712.6 CDF36944.1 - 0.044 14.2 5.6 4.3 7.8 0.0 3.0 2 1 1 3 3 3 0 Snapin/Pallidin Laminin_II PF06009.12 CDF36944.1 - 0.15 12.0 9.7 0.27 11.3 1.7 2.1 2 0 0 2 2 2 0 Laminin Domain II CENP-F_leu_zip PF10473.9 CDF36944.1 - 0.24 11.4 14.0 0.54 10.3 7.7 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 CDF36944.1 - 0.93 9.5 9.6 3.2 7.8 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) eIF3_N PF09440.10 CDF36944.1 - 2.4 8.6 10.5 0.61 10.5 0.3 2.7 1 1 2 3 3 3 0 eIF3 subunit 6 N terminal domain KLRAQ PF10205.9 CDF36944.1 - 3.2 8.1 12.8 0.24 11.7 4.4 2.3 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein FAM76 PF16046.5 CDF36944.1 - 6.2 6.1 10.6 1.8 7.9 3.9 2.0 1 1 1 2 2 2 0 FAM76 protein Sas10 PF09368.10 CDF36945.1 - 2.5e-18 66.3 4.8 2.5e-18 66.3 4.8 3.0 4 0 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CDF36945.1 - 0.0015 19.1 0.6 0.0062 17.1 0.0 2.4 2 0 0 2 2 2 1 Sas10/Utp3/C1D family YbjQ_1 PF01906.17 CDF36945.1 - 0.067 13.8 0.5 0.22 12.2 0.0 2.0 2 0 0 2 2 2 0 Putative heavy-metal-binding DUF3523 PF12037.8 CDF36946.1 - 1e-75 254.5 27.7 1.8e-75 253.8 27.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 CDF36946.1 - 4.3e-23 82.2 0.0 9.7e-23 81.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDF36946.1 - 0.0002 21.1 0.0 0.00049 19.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF36946.1 - 0.00027 21.4 10.4 0.00041 20.8 0.0 3.3 2 2 1 3 3 2 2 AAA ATPase domain Sigma54_activ_2 PF14532.6 CDF36946.1 - 0.0014 18.8 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 CDF36946.1 - 0.0015 19.1 4.8 0.026 15.1 0.0 3.2 3 1 0 3 3 3 1 AAA domain TsaE PF02367.17 CDF36946.1 - 0.0022 18.0 0.1 0.0068 16.4 0.0 1.8 2 0 0 2 2 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 CDF36946.1 - 0.0027 17.7 0.0 0.0096 15.9 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_5 PF07728.14 CDF36946.1 - 0.0083 16.1 1.6 0.071 13.1 0.1 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDF36946.1 - 0.0083 16.3 0.0 0.0083 16.3 0.0 3.1 3 1 2 5 5 5 1 AAA domain Mg_chelatase PF01078.21 CDF36946.1 - 0.012 15.0 0.0 0.034 13.5 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDF36946.1 - 0.019 14.7 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase PF06745.13 CDF36946.1 - 0.019 14.3 1.4 0.03 13.7 0.0 2.0 3 0 0 3 3 2 0 KaiC AAA_3 PF07726.11 CDF36946.1 - 0.023 14.5 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CDF36946.1 - 0.031 14.0 0.0 0.073 12.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CDF36946.1 - 0.037 13.2 0.0 0.037 13.2 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain Borrelia_P83 PF05262.11 CDF36946.1 - 0.037 12.5 16.3 0.045 12.2 16.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein NACHT PF05729.12 CDF36946.1 - 0.056 13.4 0.0 0.46 10.4 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 CDF36946.1 - 0.064 13.3 0.0 0.24 11.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF36946.1 - 0.11 12.1 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 CDF36946.1 - 0.13 12.5 7.1 0.94 9.8 0.1 3.4 2 2 1 4 4 3 0 AAA domain RNA_helicase PF00910.22 CDF36946.1 - 0.13 12.6 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase E1-E2_ATPase PF00122.20 CDF36946.1 - 0.14 11.7 0.0 0.33 10.5 0.0 1.6 1 0 0 1 1 1 0 E1-E2 ATPase AAA_11 PF13086.6 CDF36946.1 - 0.25 11.1 0.0 0.25 11.1 0.0 3.1 2 1 0 2 2 1 0 AAA domain tRNA-synt_1b PF00579.25 CDF36947.1 - 2.4e-60 204.4 0.0 3e-60 204.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Pro_isomerase PF00160.21 CDF36948.1 - 3.2e-41 141.3 0.1 3.7e-41 141.0 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.25 CDF36950.1 - 0.0046 16.3 0.0 0.022 14.1 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 CDF36950.1 - 0.0087 15.4 0.2 0.021 14.2 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ParD_antitoxin PF03693.14 CDF36950.1 - 0.26 11.7 1.3 1.5 9.3 0.1 2.3 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH RPE65 PF03055.15 CDF36951.1 - 0.0041 16.4 0.0 0.0041 16.4 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Pkinase PF00069.25 CDF36952.1 - 0.005 16.2 0.0 0.023 14.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Hyd_WA PF06462.12 CDF36954.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Propeller Peptidase_A21 PF03566.13 CDF36956.1 - 1.3 7.2 3.2 1.3 7.2 3.2 1.0 1 0 0 1 1 1 0 Peptidase family A21 LSM PF01423.22 CDF36960.1 - 4.5e-17 61.5 0.0 7.6e-17 60.8 0.0 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDF36960.1 - 0.0019 18.3 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Ribosomal_S16 PF00886.19 CDF36961.1 - 6.1e-25 87.1 0.2 8e-25 86.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 TruB_C PF09142.11 CDF36961.1 - 0.018 14.8 0.2 0.029 14.2 0.2 1.3 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal RPE65 PF03055.15 CDF36963.1 - 7.1e-111 371.6 0.3 8.4e-111 371.4 0.3 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Cullin PF00888.22 CDF36964.1 - 8.9e-139 463.9 1.4 8.9e-139 463.9 1.4 1.7 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 CDF36964.1 - 3e-23 81.6 1.0 1.6e-22 79.3 0.6 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain DXP_synthase_N PF13292.6 CDF36966.1 - 1.1e-105 352.7 0.0 3.8e-105 351.0 0.0 1.9 3 0 0 3 3 3 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDF36966.1 - 1.4e-39 135.6 0.0 2.2e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDF36966.1 - 4.5e-25 87.9 0.0 1.2e-24 86.6 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transketolase_N PF00456.21 CDF36966.1 - 7e-05 21.9 0.1 0.15 11.0 0.0 3.0 3 0 0 3 3 3 2 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.20 CDF36966.1 - 0.00021 20.3 0.0 0.00033 19.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Pribosyltran PF00156.27 CDF36969.1 - 5.5e-09 35.7 0.0 1.1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Ham1p_like PF01725.16 CDF36969.1 - 5.5e-07 29.7 0.1 1.1e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 Ham1 family UPF0302 PF08864.10 CDF36969.1 - 0.11 12.5 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 UPF0302 domain DUF393 PF04134.12 CDF36970.1 - 7e-25 88.6 0.0 1.4e-24 87.6 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function, DUF393 FAD_binding_1 PF00667.20 CDF36971.1 - 4.7e-43 147.3 0.0 6.3e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CDF36971.1 - 2.5e-23 82.9 0.0 4.7e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CDF36971.1 - 7.9e-17 61.9 0.0 1.6e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Peptidase_C97 PF05903.14 CDF36973.1 - 1.4e-19 70.4 0.0 2.1e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 CDF36973.1 - 8.7e-16 58.0 0.2 1.3e-15 57.4 0.2 1.2 1 0 0 1 1 1 1 PUL domain LRAT PF04970.13 CDF36973.1 - 0.26 11.6 0.4 0.95 9.8 0.5 1.8 2 0 0 2 2 2 0 Lecithin retinol acyltransferase Methyltransf_8 PF05148.15 CDF36979.1 - 3.6e-66 223.2 0.0 1.1e-63 215.0 0.0 2.0 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CDF36979.1 - 3.2e-08 34.1 0.0 1.6e-07 31.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF36979.1 - 1.2e-05 26.0 0.0 0.0011 19.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF36979.1 - 0.00019 21.3 0.0 0.3 10.9 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CDF36979.1 - 0.0075 16.1 0.0 0.015 15.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF36979.1 - 0.14 12.9 0.0 4.2 8.2 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Sec1 PF00995.23 CDF36982.1 - 9.9e-103 345.3 0.0 1.1e-102 345.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Tape_meas_lam_C PF09718.10 CDF36982.1 - 0.16 12.1 1.4 1.3 9.2 0.1 2.6 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) PWWP PF00855.17 CDF36985.1 - 3.8e-13 49.7 0.2 9e-13 48.5 0.2 1.7 1 0 0 1 1 1 1 PWWP domain Agenet PF05641.12 CDF36985.1 - 0.045 14.2 1.6 0.063 13.8 0.4 1.9 2 0 0 2 2 2 0 Agenet domain DTHCT PF08070.11 CDF36985.1 - 3 8.6 16.3 1 10.2 6.1 2.4 2 0 0 2 2 2 0 DTHCT (NUC029) region TIP49 PF06068.13 CDF36986.1 - 2.4e-158 526.9 2.2 3.7e-158 526.3 2.2 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDF36986.1 - 1e-24 86.5 0.3 2.5e-24 85.2 0.3 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 CDF36986.1 - 3.7e-08 33.9 1.9 1.3e-05 25.6 0.2 3.1 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CDF36986.1 - 5.5e-08 32.5 0.9 1.2e-07 31.3 0.9 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.12 CDF36986.1 - 9.5e-06 25.4 0.9 0.0025 17.6 0.1 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDF36986.1 - 6.9e-05 22.9 0.9 0.0025 17.8 0.0 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDF36986.1 - 0.00023 21.6 0.3 0.0012 19.3 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 CDF36986.1 - 0.0003 20.5 0.1 0.11 12.2 0.1 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 CDF36986.1 - 0.00043 19.9 0.0 0.001 18.7 0.1 1.8 2 0 0 2 2 1 1 AAA domain NACHT PF05729.12 CDF36986.1 - 0.0005 20.0 0.1 0.0016 18.4 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CDF36986.1 - 0.00057 20.2 1.3 1 9.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 CDF36986.1 - 0.00062 20.1 4.6 0.0093 16.3 4.6 2.4 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CDF36986.1 - 0.001 18.5 0.1 0.0022 17.4 0.1 1.5 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.9 CDF36986.1 - 0.0015 17.8 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 CDF36986.1 - 0.0016 17.9 1.9 0.011 15.1 0.6 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDF36986.1 - 0.0076 15.6 0.6 0.018 14.3 0.6 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_23 PF13476.6 CDF36986.1 - 0.01 16.3 0.1 0.02 15.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF36986.1 - 0.016 14.9 2.4 0.13 12.0 0.9 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDF36986.1 - 0.018 14.6 0.5 0.053 13.0 0.1 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 CDF36986.1 - 0.046 13.5 0.1 0.11 12.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 CDF36986.1 - 0.068 12.9 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase III, delta subunit TsaE PF02367.17 CDF36986.1 - 0.069 13.2 1.1 0.16 12.0 0.1 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CDF36986.1 - 0.071 13.4 0.3 0.21 11.8 0.3 1.8 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 CDF36986.1 - 0.072 13.6 0.5 0.55 10.8 0.5 2.5 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 CDF36986.1 - 0.21 11.5 1.1 4.2 7.4 1.1 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_2 PF07724.14 CDF36986.1 - 0.6 10.2 3.6 0.74 9.9 0.7 2.7 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) PI3_PI4_kinase PF00454.27 CDF36989.1 - 1.8e-09 37.8 0.1 7.3e-08 32.5 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 CDF36989.1 - 0.0033 16.8 0.0 0.0051 16.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) rve PF00665.26 CDF36991.1 - 1.4e-05 25.2 0.0 3.1e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain AAA_lid_5 PF17865.1 CDF36991.1 - 0.14 12.2 0.1 0.26 11.4 0.1 1.3 1 0 0 1 1 1 0 Midasin AAA lid domain Glyco_transf_49 PF13896.6 CDF36993.1 - 0.00057 19.3 0.0 0.14 11.5 0.0 2.1 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_transf_49 PF13896.6 CDF36994.1 - 7.5e-13 48.5 0.1 9.5e-13 48.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Lenti_VIF_2 PF07401.12 CDF36994.1 - 0.092 12.1 0.1 0.096 12.0 0.1 1.2 1 0 0 1 1 1 0 Bovine Lentivirus VIF protein Ins_P5_2-kin PF06090.12 CDF36996.1 - 1.1e-25 90.8 0.0 1.6e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase ATP-grasp_4 PF13535.6 CDF36998.1 - 4.1e-19 68.7 0.0 7.4e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_N PF18130.1 CDF36998.1 - 2.9e-11 43.8 0.2 7.3e-11 42.5 0.2 1.7 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATP-grasp_3 PF02655.14 CDF36998.1 - 1.1e-08 35.3 0.0 2.3e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CDF36998.1 - 2e-06 27.7 0.1 0.00015 21.6 0.0 2.9 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_Ter PF15632.6 CDF36998.1 - 1.3e-05 24.9 0.0 0.00015 21.5 0.0 2.4 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 CDF36998.1 - 8.7e-05 22.1 0.0 0.00021 20.9 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.11 CDF36998.1 - 0.0011 18.6 0.0 0.0046 16.6 0.0 2.1 3 0 0 3 3 3 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.17 CDF36998.1 - 0.0095 15.4 0.0 0.027 14.0 0.0 1.8 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 CDF36998.1 - 0.05 13.2 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain LAL_C2 PF18603.1 CDF36998.1 - 0.14 12.3 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 L-amino acid ligase C-terminal domain 2 Ribonuclease_3 PF00636.26 CDF36999.1 - 1.1e-46 157.8 0.0 2.2e-22 79.7 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CDF36999.1 - 2.8e-31 108.3 0.0 1.4e-14 54.4 0.0 3.4 2 1 0 2 2 2 2 Ribonuclease-III-like PAZ PF02170.22 CDF36999.1 - 2.3e-05 24.2 0.0 4.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 PAZ domain dsrm PF00035.26 CDF36999.1 - 0.0004 21.0 0.0 0.001 19.7 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif Bax1-I PF01027.20 CDF37001.1 - 1.4e-28 100.1 19.2 2e-28 99.7 19.2 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Str_synth PF03088.16 CDF37001.1 - 0.072 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Strictosidine synthase CIA30 PF08547.12 CDF37002.1 - 2.6e-43 147.8 0.1 3.5e-43 147.4 0.1 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) NAD_binding_10 PF13460.6 CDF37002.1 - 7.6e-21 74.8 0.2 7.4e-12 45.5 0.0 2.3 2 0 0 2 2 2 2 NAD(P)H-binding NmrA PF05368.13 CDF37002.1 - 0.00016 21.3 1.4 0.008 15.7 0.9 2.8 2 1 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 CDF37002.1 - 0.00018 20.8 0.3 0.052 12.7 0.6 2.4 2 1 0 2 2 2 2 Male sterility protein CBM_11 PF03425.13 CDF37002.1 - 0.00022 21.1 0.0 0.00035 20.5 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain (family 11) adh_short PF00106.25 CDF37002.1 - 0.0018 17.8 0.3 0.0031 17.0 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CDF37002.1 - 0.037 13.2 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein QSOX_Trx1 PF18108.1 CDF37002.1 - 0.047 13.9 0.1 0.16 12.1 0.1 1.9 2 0 0 2 2 2 0 QSOX Trx-like domain MEDS PF14417.6 CDF37002.1 - 0.24 11.2 0.0 0.48 10.3 0.0 1.5 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain RHD3 PF05879.12 CDF37004.1 - 2.7e-155 518.5 0.0 1.5e-152 509.4 0.0 2.3 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 CDF37004.1 - 7.2e-05 22.8 0.0 0.00018 21.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDF37004.1 - 0.0016 18.5 0.0 0.0038 17.3 0.0 1.6 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CDF37004.1 - 0.0037 17.5 0.3 0.016 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CDF37004.1 - 0.014 15.9 0.0 0.052 14.1 0.0 1.9 1 0 0 1 1 1 0 ABC transporter GBP PF02263.19 CDF37004.1 - 0.02 14.2 0.0 0.037 13.3 0.0 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain AAA_29 PF13555.6 CDF37004.1 - 0.083 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CDF37004.1 - 0.2 12.1 0.0 0.36 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cse1 PF08506.10 CDF37005.1 - 2.4e-115 385.3 0.2 4.1e-115 384.5 0.2 1.4 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 CDF37005.1 - 2.9e-100 335.9 0.3 7.4e-100 334.5 0.3 1.7 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 CDF37005.1 - 7.7e-07 28.9 0.0 5.6e-06 26.2 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CDF37005.1 - 0.00022 21.3 2.7 0.0017 18.4 0.2 3.4 3 1 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 CDF37005.1 - 0.009 16.2 0.0 0.59 10.5 0.1 3.9 3 0 0 3 3 3 1 HEAT repeat DCB PF16213.5 CDF37005.1 - 0.078 12.6 2.0 0.74 9.4 0.1 2.7 2 1 1 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 DUF3535 PF12054.8 CDF37005.1 - 0.087 12.0 0.2 12 5.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3535) HEAT_EZ PF13513.6 CDF37005.1 - 7 7.3 12.0 19 5.9 0.1 6.8 9 0 0 9 9 9 0 HEAT-like repeat Syja_N PF02383.18 CDF37006.1 - 2e-74 250.8 0.0 2.6e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain 2-oxoacid_dh PF00198.23 CDF37006.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) M16C_assoc PF08367.11 CDF37007.1 - 5.6e-65 218.9 0.0 8.7e-65 218.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 CDF37007.1 - 4.6e-20 72.4 0.1 3.4e-19 69.6 0.0 2.3 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDF37007.1 - 1.5e-09 38.0 0.0 5.6e-09 36.1 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) UCH PF00443.29 CDF37008.1 - 3.5e-62 210.2 0.3 4e-62 210.0 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF37008.1 - 1.9e-33 116.4 1.8 7.6e-33 114.4 1.8 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CDF37008.1 - 0.00033 20.2 6.1 0.26 10.7 4.0 3.4 3 1 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Med25 PF11232.8 CDF37008.1 - 0.017 15.1 0.0 0.046 13.7 0.0 1.7 2 0 0 2 2 2 0 Mediator complex subunit 25 PTOV activation and synapsin 2 ABA_GPCR PF12430.8 CDF37011.1 - 4.8e-25 88.4 4.0 6.9e-25 87.9 4.0 1.2 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 CDF37011.1 - 3.6e-08 33.4 2.2 4.1e-08 33.2 0.0 2.3 3 0 0 3 3 3 1 The Golgi pH Regulator (GPHR) Family N-terminal Pkinase PF00069.25 CDF37012.1 - 1.8e-09 37.4 0.0 2e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CDF37012.1 - 2.1e-07 31.1 0.1 2.7e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF37012.1 - 1.4e-06 27.8 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDF37012.1 - 3.9e-06 26.6 0.1 4.7e-06 26.3 0.1 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 CDF37012.1 - 0.00048 19.5 0.0 0.00057 19.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF37012.1 - 0.0025 16.7 0.0 0.0027 16.6 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDF37012.1 - 0.026 14.1 0.0 0.031 13.9 0.0 1.1 1 0 0 1 1 1 0 RIO1 family EcKinase PF02958.20 CDF37012.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase Haspin_kinase PF12330.8 CDF37012.1 - 0.12 11.2 0.0 0.23 10.4 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase PF00069.25 CDF37014.1 - 1.8e-09 37.4 0.0 2e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CDF37014.1 - 2.1e-07 31.1 0.1 2.7e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF37014.1 - 1.4e-06 27.8 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDF37014.1 - 3.9e-06 26.6 0.1 4.7e-06 26.3 0.1 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 CDF37014.1 - 0.00048 19.5 0.0 0.00057 19.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF37014.1 - 0.0025 16.7 0.0 0.0027 16.6 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDF37014.1 - 0.026 14.1 0.0 0.031 13.9 0.0 1.1 1 0 0 1 1 1 0 RIO1 family EcKinase PF02958.20 CDF37014.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase Haspin_kinase PF12330.8 CDF37014.1 - 0.12 11.2 0.0 0.23 10.4 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain PIF1 PF05970.14 CDF37017.1 - 6e-84 282.3 0.0 2.7e-69 234.1 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF37017.1 - 4e-59 200.1 0.0 7.3e-59 199.2 0.0 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF37017.1 - 1.5e-13 50.9 0.0 2.7e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF37017.1 - 0.012 16.0 0.0 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AMNp_N PF10423.9 CDF37017.1 - 0.054 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus AAA_16 PF13191.6 CDF37017.1 - 0.071 13.5 1.0 0.25 11.7 0.0 2.4 2 1 1 3 3 3 0 AAA ATPase domain Herpes_Helicase PF02689.14 CDF37017.1 - 0.086 10.7 0.0 0.14 10.0 0.0 1.2 1 0 0 1 1 1 0 Helicase AAA_5 PF07728.14 CDF37017.1 - 0.15 12.1 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GATase PF00117.28 CDF37019.1 - 5.2e-43 147.0 0.0 1.1e-42 146.0 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 CDF37019.1 - 7e-42 141.4 0.0 1.5e-41 140.3 0.0 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain Peptidase_C26 PF07722.13 CDF37019.1 - 1.2e-09 38.3 0.0 3.2e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 CDF37019.1 - 6.5e-08 32.0 0.1 3.7e-06 26.2 0.2 2.8 3 0 0 3 3 3 1 NAD synthase tRNA_Me_trans PF03054.16 CDF37019.1 - 0.00032 19.6 0.2 0.00056 18.8 0.2 1.3 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 CDF37019.1 - 0.00086 18.9 0.0 0.026 14.0 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 CDF37019.1 - 0.0056 16.0 0.1 0.0084 15.4 0.1 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase PAPS_reduct PF01507.19 CDF37019.1 - 0.014 15.4 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Asn_synthase PF00733.21 CDF37019.1 - 0.023 14.4 0.1 0.046 13.4 0.1 1.4 2 0 0 2 2 2 0 Asparagine synthase ThiI PF02568.14 CDF37019.1 - 0.058 13.0 0.1 0.094 12.3 0.1 1.4 1 1 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 CDF37019.1 - 0.071 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 PP-loop family VHS PF00790.19 CDF37019.1 - 0.11 12.4 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 VHS domain FXMRP1_C_core PF12235.8 CDF37023.1 - 0.15 12.7 3.1 0.19 12.4 3.1 1.1 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal DAO PF01266.24 CDF37024.1 - 3.2e-12 46.7 0.3 7.4e-12 45.5 0.3 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDF37024.1 - 2.1e-10 40.7 3.0 6.8e-10 39.0 1.8 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CDF37024.1 - 2.1e-10 40.5 0.7 4.1e-10 39.6 0.7 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 CDF37024.1 - 4.5e-07 29.3 6.4 3.4e-05 23.1 1.3 2.3 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 CDF37024.1 - 0.00015 20.6 0.1 0.27 9.9 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 CDF37024.1 - 0.00033 20.0 0.2 0.00062 19.1 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CDF37024.1 - 0.00095 18.5 0.8 0.0012 18.2 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDF37024.1 - 0.0045 16.3 0.1 0.0094 15.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain GMC_oxred_N PF00732.19 CDF37024.1 - 0.052 12.9 0.1 0.098 12.0 0.1 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Pyr_redox_3 PF13738.6 CDF37024.1 - 0.069 12.4 0.7 0.12 11.7 0.2 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF37024.1 - 0.11 13.0 2.4 0.27 11.8 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase YlmH_RBD PF17774.1 CDF37025.1 - 5.2e-12 45.9 0.0 9.3e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Putative RNA-binding domain in YlmH S4 PF01479.25 CDF37025.1 - 1.5e-06 27.8 0.0 3.3e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 S4 domain DUF1062 PF06353.12 CDF37025.1 - 0.0027 18.5 0.1 0.0046 17.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1062) FA_desaturase PF00487.24 CDF37028.1 - 8.5e-30 104.4 19.4 1.5e-29 103.7 19.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CDF37028.1 - 0.00079 19.6 0.0 0.0024 18.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Ribosomal_L7Ae PF01248.26 CDF37029.1 - 2.1e-21 75.4 0.2 4.9e-21 74.3 0.2 1.7 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 CDF37029.1 - 0.00016 21.8 0.1 0.00031 20.8 0.0 1.5 2 0 0 2 2 2 1 RNase P subunit Pop3 Sod_Fe_C PF02777.18 CDF37030.1 - 7.4e-36 122.4 0.1 1.5e-35 121.4 0.0 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDF37030.1 - 2.4e-23 82.4 0.5 2.4e-23 82.4 0.5 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain FKBP_C PF00254.28 CDF37031.1 - 1.1e-20 73.8 0.0 1.7e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pyr_redox_2 PF07992.14 CDF37032.1 - 2e-30 106.0 0.0 2.9e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF37032.1 - 5.6e-10 39.6 0.2 1.3e-09 38.5 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDF37032.1 - 2.5e-05 24.0 0.4 0.088 12.4 0.1 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDF37032.1 - 0.0089 16.0 0.7 4.8 7.1 0.0 3.2 3 1 1 4 4 4 2 FAD-NAD(P)-binding HI0933_like PF03486.14 CDF37032.1 - 0.022 13.5 0.0 3.5 6.2 0.1 2.2 1 1 1 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 CDF37032.1 - 0.031 13.1 0.2 0.078 11.8 0.0 1.7 2 1 0 2 2 2 0 Tryptophan halogenase K_oxygenase PF13434.6 CDF37032.1 - 0.052 12.7 0.2 0.28 10.3 0.0 2.1 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CDF37032.1 - 0.12 11.4 0.8 2.2 7.3 0.0 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CDF37032.1 - 0.22 10.7 0.0 0.41 9.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Tyrosinase PF00264.20 CDF37033.1 - 2.8e-28 99.7 6.6 2.8e-28 99.7 6.6 3.0 3 1 0 3 3 3 1 Common central domain of tyrosinase PPDK_N PF01326.19 CDF37035.1 - 7.7e-36 124.0 0.6 2.6e-35 122.3 0.6 1.7 2 0 0 2 2 2 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain CBM_20 PF00686.19 CDF37035.1 - 1.1e-09 38.0 0.0 2.4e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain AMH_N PF04709.12 CDF37040.1 - 0.2 10.5 0.3 0.27 10.1 0.3 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region Clat_adaptor_s PF01217.20 CDF37042.1 - 5.3e-37 126.9 0.2 5.8e-37 126.8 0.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF155 PF02582.14 CDF37043.1 - 4.8e-42 144.0 0.0 6.5e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 GSH_synth_ATP PF03917.17 CDF37045.1 - 3.6e-103 345.2 0.0 4.4e-103 344.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CDF37045.1 - 4e-29 101.1 0.0 6.3e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic glutathione synthase dsDNA_bind PF01984.20 CDF37046.1 - 1.5e-31 108.9 11.6 1.9e-31 108.6 11.6 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Tic110 PF16940.5 CDF37047.1 - 5.3e-05 21.9 3.5 8.8e-05 21.2 1.6 2.0 1 1 1 2 2 2 1 Chloroplast envelope transporter SWIB PF02201.18 CDF37048.1 - 2.6e-46 155.4 0.1 3.3e-24 84.6 0.0 2.9 3 0 0 3 3 3 2 SWIB/MDM2 domain DEK_C PF08766.11 CDF37048.1 - 3.3e-08 33.3 0.1 3.3e-08 33.3 0.1 2.1 2 0 0 2 2 2 1 DEK C terminal domain Patatin PF01734.22 CDF37049.1 - 5.2e-13 49.6 8.6 1.7e-12 48.0 5.3 2.5 2 1 0 2 2 2 1 Patatin-like phospholipase NTP_transf_3 PF12804.7 CDF37050.1 - 5e-05 23.7 0.0 7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fip1 PF05182.13 CDF37051.1 - 2e-20 72.0 1.5 3.5e-20 71.2 1.5 1.3 1 0 0 1 1 1 1 Fip1 motif Diphtheria_T PF02764.14 CDF37051.1 - 0.16 12.0 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Diphtheria toxin, T domain UQ_con PF00179.26 CDF37052.1 - 5.1e-20 71.6 0.0 6.9e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Proteasome PF00227.26 CDF37053.1 - 1.4e-61 207.3 0.2 1.9e-61 206.9 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF37053.1 - 3.5e-11 42.6 0.0 6.9e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Adaptin_N PF01602.20 CDF37054.1 - 1e-75 255.3 3.2 5.2e-71 239.8 1.8 2.9 2 1 0 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 CDF37054.1 - 1e-18 67.6 0.0 2.4e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 CDF37054.1 - 1e-07 32.2 0.2 8.8e-05 22.6 0.1 2.6 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDF37054.1 - 6.2e-07 29.7 1.7 0.86 10.0 0.0 4.9 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 CDF37054.1 - 0.00061 19.8 0.7 19 5.9 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat Proteasom_PSMB PF10508.9 CDF37054.1 - 0.0042 15.7 5.6 0.04 12.4 0.2 2.2 2 0 0 2 2 2 2 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.8 CDF37054.1 - 0.048 13.8 0.0 0.65 10.1 0.0 2.9 2 0 0 2 2 2 0 V-ATPase subunit H Evr1_Alr PF04777.13 CDF37056.1 - 1.1e-25 89.9 0.6 1.1e-25 89.9 0.6 1.8 1 1 1 2 2 2 1 Erv1 / Alr family Ribosomal_S19e PF01090.19 CDF37057.1 - 8e-55 184.3 0.0 9.8e-55 184.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.10 CDF37057.1 - 0.006 16.5 0.2 0.0096 15.9 0.2 1.3 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_41 PF14502.6 CDF37057.1 - 0.036 13.8 0.2 0.072 12.8 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Mrr_N PF14338.6 CDF37057.1 - 0.067 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Mrr N-terminal domain HrcA_DNA-bdg PF03444.15 CDF37057.1 - 0.094 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding YppF PF14178.6 CDF37057.1 - 0.26 11.2 0.3 1.3 8.9 0.1 1.9 2 0 0 2 2 2 0 YppF-like protein Tim17 PF02466.19 CDF37058.1 - 1.1e-16 61.2 12.2 1.5e-16 60.7 12.2 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Ribosomal_S19e PF01090.19 CDF37059.1 - 0.047 13.4 0.1 0.074 12.8 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S19e DUF1045 PF06299.12 CDF37059.1 - 0.13 12.3 0.1 0.28 11.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1045) zf-HIT PF04438.16 CDF37062.1 - 1.9e-09 37.2 9.3 3e-09 36.6 9.3 1.3 1 0 0 1 1 1 1 HIT zinc finger G_glu_transpept PF01019.21 CDF37065.1 - 9.6e-130 433.7 0.7 1e-89 301.7 0.0 2.8 2 1 0 2 2 2 2 Gamma-glutamyltranspeptidase Sun2_CC2 PF18580.1 CDF37065.1 - 0.18 12.1 3.3 62 3.9 0.0 4.3 4 0 0 4 4 4 0 SUN2 coiled coil domain 2 JIP_LZII PF16471.5 CDF37069.1 - 0.13 12.5 4.7 3.1 8.1 0.1 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Shugoshin_N PF07558.11 CDF37069.1 - 0.22 11.4 6.5 3.1 7.7 1.1 2.7 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF3450 PF11932.8 CDF37069.1 - 0.27 10.5 2.7 0.46 9.8 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Lzipper-MIP1 PF14389.6 CDF37069.1 - 0.41 11.0 3.6 15 6.0 1.3 2.5 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 BRE1 PF08647.11 CDF37069.1 - 0.47 10.6 11.2 0.78 9.8 11.2 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase HALZ PF02183.18 CDF37069.1 - 0.65 10.3 11.2 0.067 13.4 4.1 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 CDF37069.1 - 0.76 10.5 7.2 9.9 6.9 0.6 2.4 1 1 1 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 CDF37069.1 - 0.8 9.5 7.7 1.3 8.9 1.5 2.6 2 0 0 2 2 2 0 Septum formation initiator GAS PF13851.6 CDF37069.1 - 0.84 9.0 8.9 1.4 8.2 8.9 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ZapB PF06005.12 CDF37069.1 - 1.5 9.3 10.8 1.9 9.0 3.4 2.3 1 1 1 2 2 2 0 Cell division protein ZapB bZIP_2 PF07716.15 CDF37069.1 - 2.1 8.5 12.2 0.24 11.5 0.8 3.3 2 2 2 4 4 4 0 Basic region leucine zipper SSF PF00474.17 CDF37071.1 - 8.4e-20 71.0 27.6 8.4e-20 71.0 27.6 1.5 2 0 0 2 2 2 1 Sodium:solute symporter family C_GCAxxG_C_C PF09719.10 CDF37071.1 - 0.24 11.7 0.3 0.48 10.7 0.3 1.4 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) Deltameth_res PF16020.5 CDF37071.1 - 8.1 6.4 8.3 1.1 9.2 0.6 3.6 3 0 0 3 3 3 0 Deltamethrin resistance GST_N_3 PF13417.6 CDF37073.1 - 8.2e-12 45.4 0.0 1.5e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF37073.1 - 1.4e-07 31.7 0.0 2.4e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDF37073.1 - 1.9e-07 31.0 0.0 7.2e-07 29.2 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDF37073.1 - 6.5e-05 23.2 0.0 0.00012 22.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 CDF37073.1 - 0.0035 17.9 0.0 0.0059 17.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDF37073.1 - 0.0052 16.9 0.0 0.0086 16.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain zf-MIZ PF02891.20 CDF37073.1 - 0.077 12.8 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Tim17 PF02466.19 CDF37074.1 - 3.2e-07 30.7 8.7 4.9e-07 30.1 8.7 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DTW PF03942.15 CDF37075.1 - 2.1e-18 66.8 0.0 3.3e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 DTW domain UNC-50 PF05216.13 CDF37076.1 - 9.3e-81 270.6 23.7 1e-80 270.4 23.7 1.0 1 0 0 1 1 1 1 UNC-50 family Hormone_4 PF00220.17 CDF37077.1 - 2.7 8.2 4.3 8.2 6.7 4.3 1.8 1 0 0 1 1 1 0 Neurohypophysial hormones, N-terminal Domain Abhydrolase_1 PF00561.20 CDF37079.1 - 2.9e-17 63.2 0.0 3.8e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF37079.1 - 1.2e-07 32.6 0.0 1.5e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family tRNA-synt_1d PF00750.19 CDF37079.1 - 0.22 10.4 0.0 0.35 9.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (R) LPMO_10 PF03067.15 CDF37082.1 - 7.4e-19 69.2 0.2 1.4e-18 68.3 0.2 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading DUF2895 PF11444.8 CDF37083.1 - 0.067 12.6 0.0 0.075 12.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) PAPA-1 PF04795.12 CDF37084.1 - 2e-09 38.1 6.9 2e-09 38.1 6.9 4.5 4 1 1 5 5 5 1 PAPA-1-like conserved region Rtf2 PF04641.12 CDF37086.1 - 1.4e-16 60.6 0.3 1.3e-14 54.2 0.3 2.2 1 1 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 CDF37086.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein XRN_N PF03159.18 CDF37087.1 - 1.1e-93 313.1 0.0 1.3e-93 312.9 0.0 1.1 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus YchF-GTPase_C PF06071.13 CDF37088.1 - 1.7e-35 121.0 0.5 3.9e-35 119.9 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CDF37088.1 - 2e-20 73.0 0.0 6.4e-20 71.3 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF37088.1 - 1.2e-07 31.4 0.0 2.6e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 CDF37088.1 - 0.00084 19.5 0.0 0.066 13.4 0.0 2.7 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CDF37088.1 - 0.093 13.3 0.0 4.9 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain TGS PF02824.21 CDF37088.1 - 0.11 12.5 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 TGS domain Cupin_2 PF07883.11 CDF37088.1 - 0.17 11.6 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 Cupin domain AraC_binding PF02311.19 CDF37088.1 - 0.2 11.5 0.0 0.38 10.7 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain PLD_C PF12357.8 CDF37089.1 - 8e-15 54.5 0.0 2.3e-14 53.0 0.0 1.8 1 0 0 1 1 1 1 Phospholipase D C terminal C2 PF00168.30 CDF37089.1 - 3.9e-14 52.8 0.0 1.1e-13 51.3 0.0 1.8 2 0 0 2 2 2 1 C2 domain PLDc PF00614.22 CDF37089.1 - 2.8e-13 49.5 3.9 2.4e-06 27.5 0.1 3.7 3 1 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CDF37089.1 - 2.1e-09 37.3 0.1 2.7e-07 30.6 0.0 3.2 3 0 0 3 3 3 1 PLD-like domain Prok-JAB PF14464.6 CDF37089.1 - 0.0033 17.2 0.2 0.0083 15.9 0.2 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Ribosomal_L27_C PF18471.1 CDF37092.1 - 0.048 13.1 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal L27 protein C-terminal domain HTH_Tnp_Tc3_1 PF11427.8 CDF37093.1 - 1.6e-07 31.1 0.8 5.3e-07 29.4 0.1 2.3 3 0 0 3 3 3 1 Tc3 transposase HTH_38 PF13936.6 CDF37093.1 - 2.3e-06 27.2 0.3 4.8e-06 26.2 0.3 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDF37093.1 - 0.0048 17.1 0.4 0.025 14.8 0.2 2.1 1 1 1 2 2 2 1 Transposase HTH_29 PF13551.6 CDF37093.1 - 0.057 13.5 0.3 0.84 9.7 0.1 2.5 1 1 1 2 2 2 0 Winged helix-turn helix HTH_23 PF13384.6 CDF37093.1 - 0.079 12.8 0.8 0.37 10.6 0.0 2.4 2 1 0 2 2 2 0 Homeodomain-like domain Enolase_C PF00113.22 CDF37094.1 - 4.5e-58 196.8 0.0 5.3e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain MR_MLE_C PF13378.6 CDF37094.1 - 0.00025 20.7 0.1 0.006 16.2 0.0 1.9 1 1 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDF37094.1 - 0.031 13.4 0.1 0.039 13.1 0.1 1.1 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus GST_N_3 PF13417.6 CDF37095.1 - 7.4e-14 51.9 0.0 1.9e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF37095.1 - 2.6e-09 37.3 0.0 8.1e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDF37095.1 - 4.1e-07 30.2 0.0 8.8e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CDF37095.1 - 0.008 16.4 0.0 0.02 15.1 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin Trimer_CC PF08954.11 CDF37095.1 - 0.088 12.4 0.1 0.29 10.7 0.1 1.9 1 0 0 1 1 1 0 Trimerisation motif Pheromone PF08015.11 CDF37095.1 - 1 10.4 4.7 23 6.1 5.4 2.4 2 0 0 2 2 2 0 Fungal mating-type pheromone SIMPL PF04402.14 CDF37100.1 - 2.9e-40 138.9 2.9 3.3e-40 138.7 2.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF541) NAD_binding_5 PF07994.12 CDF37102.1 - 5.5e-126 420.3 0.0 6.6e-126 420.0 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 CDF37102.1 - 6.2e-33 113.3 0.7 1.3e-32 112.3 0.7 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase FAD_binding_3 PF01494.19 CDF37103.1 - 8.3e-13 48.3 0.2 5.8e-08 32.4 0.0 2.6 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CDF37103.1 - 0.00033 20.8 0.1 0.00074 19.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CDF37103.1 - 0.00046 19.6 0.0 0.37 10.0 0.0 2.5 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 CDF37103.1 - 0.0033 16.7 0.2 0.15 11.3 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF37103.1 - 0.0057 15.4 0.1 0.29 9.8 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 CDF37103.1 - 0.046 14.3 0.2 0.12 13.0 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF37103.1 - 0.1 11.6 0.3 0.18 10.9 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 CDF37103.1 - 0.13 11.5 0.0 3.3 6.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF4218 PF13960.6 CDF37104.1 - 0.00019 21.0 0.0 0.00038 20.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) UCH PF00443.29 CDF37106.1 - 4.9e-10 39.3 0.0 7.2e-09 35.5 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ecl1 PF12855.7 CDF37106.1 - 0.064 14.4 0.8 0.064 14.4 0.8 1.9 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins RNA_pol_Rpc4 PF05132.14 CDF37106.1 - 0.61 10.5 0.0 0.61 10.5 0.0 2.9 3 1 0 3 3 3 0 RNA polymerase III RPC4 NAD_binding_10 PF13460.6 CDF37107.1 - 6.2e-24 84.9 0.8 7.7e-24 84.6 0.8 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CDF37107.1 - 9.2e-06 25.4 0.5 0.00026 20.6 0.2 2.1 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.20 CDF37107.1 - 2e-05 24.7 0.1 4.8e-05 23.5 0.1 1.8 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 CDF37107.1 - 0.00028 20.4 0.0 0.00041 19.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDF37107.1 - 0.0012 17.9 0.1 0.0017 17.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CDF37107.1 - 0.0037 17.7 0.2 0.0067 16.9 0.2 1.6 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CDF37107.1 - 0.027 13.6 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DPM2 PF07297.12 CDF37108.1 - 0.027 14.8 0.8 3.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF2789 PF10982.8 CDF37108.1 - 0.073 13.2 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) RSN1_7TM PF02714.15 CDF37109.1 - 2.8e-56 190.8 13.3 4.7e-56 190.1 13.3 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CDF37109.1 - 3.9e-16 59.8 1.9 8.4e-16 58.7 1.4 1.8 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter DHHC PF01529.20 CDF37110.1 - 9.2e-36 122.9 0.9 9.2e-36 122.9 0.9 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Yip1 PF04893.17 CDF37110.1 - 0.029 14.1 10.0 0.048 13.4 0.1 2.3 2 0 0 2 2 2 0 Yip1 domain Pkinase PF00069.25 CDF37111.1 - 9.3e-05 21.9 0.0 0.00018 21.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Aldo_ket_red PF00248.21 CDF37113.1 - 3.9e-67 226.5 0.0 4.5e-67 226.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 CDF37114.1 - 4.2e-35 121.4 0.0 5.3e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37114.1 - 5.4e-21 75.1 0.0 7.1e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CDF37115.1 - 0.13 12.1 0.1 0.46 10.3 0.1 1.8 1 1 0 1 1 1 0 Kinase associated domain 1 Proteasome PF00227.26 CDF37116.1 - 5e-34 117.4 0.0 6.5e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pkinase PF00069.25 CDF37117.1 - 7.7e-59 199.2 0.0 1e-58 198.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37117.1 - 3e-31 108.7 0.0 4.3e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF37117.1 - 2.4e-08 33.7 0.0 3.1e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CDF37117.1 - 0.00018 21.5 0.0 0.065 13.2 0.1 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family PH PF00169.29 CDF37117.1 - 0.0033 17.9 0.0 0.0076 16.7 0.0 1.6 1 0 0 1 1 1 1 PH domain Kdo PF06293.14 CDF37117.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF37117.1 - 0.019 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Aminotran_1_2 PF00155.21 CDF37118.1 - 5e-81 272.7 0.0 5.9e-81 272.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II AMP-binding PF00501.28 CDF37119.1 - 2.7e-52 177.8 0.1 2.7e-52 177.8 0.1 2.5 2 1 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDF37119.1 - 1.9e-07 32.0 0.4 1.4e-06 29.2 0.0 2.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ribul_P_3_epim PF00834.19 CDF37119.1 - 0.1 11.9 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Mem_trans PF03547.18 CDF37122.1 - 8.1e-06 24.5 4.5 1.2e-05 24.0 4.5 1.2 1 0 0 1 1 1 1 Membrane transport protein CBM_20 PF00686.19 CDF37123.1 - 3.1e-08 33.4 0.1 6.3e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 Starch binding domain DDE_3 PF13358.6 CDF37124.1 - 2.6e-18 66.2 0.0 4.1e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF37124.1 - 6.8e-10 38.6 0.0 1.3e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF37124.1 - 8.8e-07 28.6 0.5 2.1e-06 27.4 0.5 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF37124.1 - 2.2e-05 25.0 2.5 0.057 14.0 0.1 2.7 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 CDF37124.1 - 0.027 14.3 0.7 0.26 11.1 0.1 2.9 3 0 0 3 3 3 0 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF37124.1 - 0.096 12.9 0.3 0.41 10.9 0.0 2.1 1 1 1 2 2 2 0 Transposase Voltage_CLC PF00654.20 CDF37125.1 - 3.9e-38 131.6 45.0 8.8e-37 127.2 32.8 2.4 1 1 1 2 2 2 2 Voltage gated chloride channel CD20 PF04103.15 CDF37125.1 - 0.022 14.8 0.1 0.022 14.8 0.1 4.0 4 1 0 4 4 4 0 CD20-like family DDE_Tnp_4 PF13359.6 CDF37127.1 - 0.01 15.5 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DEAD PF00270.29 CDF37128.1 - 1.6e-16 60.5 0.0 2.4e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF37128.1 - 5.2e-14 52.5 0.1 8.4e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF37128.1 - 0.0026 17.8 0.0 0.0045 17.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DS PF01916.17 CDF37129.1 - 8.3e-47 159.8 0.0 1e-46 159.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DS PF01916.17 CDF37130.1 - 2e-46 158.5 0.0 2.2e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Glyco_trans_1_4 PF13692.6 CDF37133.1 - 2.3e-21 76.6 0.0 4.1e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDF37133.1 - 2.6e-20 72.6 0.0 4.7e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDF37133.1 - 0.00013 22.3 0.0 0.002 18.5 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_2 PF00535.26 CDF37133.1 - 0.0027 17.5 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 RL10P_insert PF17777.1 CDF37135.1 - 1.1e-18 66.9 0.0 1.7e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 CDF37135.1 - 2.4e-12 46.9 0.1 4e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_L37ae PF01780.19 CDF37136.1 - 8.1e-39 131.6 8.6 9.1e-39 131.4 8.6 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 CDF37136.1 - 0.0071 16.3 1.7 0.011 15.7 1.7 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 CDF37136.1 - 0.021 14.2 0.4 0.043 13.2 0.1 1.7 2 0 0 2 2 2 0 zinc-ribbon domain MTHFR_C PF12225.8 CDF37136.1 - 0.028 14.0 0.4 0.035 13.7 0.4 1.2 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal zf-Di19 PF05605.12 CDF37136.1 - 0.031 14.6 0.3 0.055 13.8 0.3 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding PALP PF00291.25 CDF37137.1 - 4.2e-67 226.6 5.9 5.1e-67 226.3 5.9 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme WD40 PF00400.32 CDF37138.1 - 4.5e-16 58.9 5.2 0.0045 17.8 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.11 CDF37138.1 - 0.0065 16.4 0.0 0.24 11.3 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A CDC45 PF02724.14 CDF37138.1 - 0.12 10.7 0.3 0.14 10.4 0.3 1.3 1 0 0 1 1 1 0 CDC45-like protein PQQ_3 PF13570.6 CDF37138.1 - 1.4 9.5 15.2 4.1 8.0 0.2 4.5 4 1 1 5 5 5 0 PQQ-like domain Phage_B PF02304.15 CDF37139.1 - 0.0046 17.3 0.1 0.022 15.2 0.1 2.2 1 0 0 1 1 1 1 Scaffold protein B Rbsn PF11464.8 CDF37140.1 - 0.043 13.6 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 Rabenosyn Rab binding domain HALZ PF02183.18 CDF37140.1 - 0.049 13.9 0.1 0.071 13.3 0.1 1.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.15 CDF37140.1 - 0.15 11.9 0.3 0.22 11.3 0.3 1.2 1 0 0 1 1 1 0 Septum formation initiator ATG16 PF08614.11 CDF37141.1 - 0.029 14.6 0.8 0.033 14.4 0.8 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 CDF37141.1 - 0.039 13.8 0.8 0.088 12.7 0.8 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mpv17_PMP22 PF04117.12 CDF37142.1 - 9.7e-19 67.4 0.6 9.7e-19 67.4 0.6 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family Pkinase PF00069.25 CDF37143.1 - 4.4e-58 196.7 0.0 4e-41 141.1 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37143.1 - 1.5e-29 103.1 0.0 3.8e-28 98.5 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF37143.1 - 0.00024 20.0 0.4 0.00055 18.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase POLO_box PF00659.18 CDF37143.1 - 0.00027 21.1 0.0 0.022 14.9 0.0 2.8 2 0 0 2 2 2 1 POLO box duplicated region APH PF01636.23 CDF37143.1 - 0.0085 16.0 2.0 0.019 14.9 0.1 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF37143.1 - 0.012 15.0 0.1 0.023 14.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF37143.1 - 0.016 14.5 0.0 0.1 11.9 0.0 2.0 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.22 CDF37143.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family CLN3 PF02487.17 CDF37144.1 - 1.6e-94 317.2 24.9 7.2e-92 308.5 24.9 2.0 1 1 0 1 1 1 1 CLN3 protein FA_desaturase PF00487.24 CDF37144.1 - 3.6 7.3 7.2 0.12 12.2 0.4 2.0 2 1 0 2 2 2 0 Fatty acid desaturase GTP_EFTU PF00009.27 CDF37145.1 - 4.7e-51 173.1 0.0 8.3e-51 172.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDF37145.1 - 9.6e-17 60.8 0.0 2.7e-16 59.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF37145.1 - 8.5e-08 32.5 0.0 2.5e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CDF37145.1 - 2.1e-07 30.9 0.0 5.8e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 CDF37145.1 - 0.0061 16.3 0.0 0.019 14.7 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 CDF37145.1 - 0.026 14.6 0.0 0.069 13.2 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase GDPD PF03009.17 CDF37146.1 - 1.1e-24 87.6 0.0 1.4e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF3933 PF13069.6 CDF37146.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3933) HSP90 PF00183.18 CDF37147.1 - 1.4e-72 245.3 4.4 1.8e-72 244.9 4.4 1.1 1 0 0 1 1 1 1 Hsp90 protein Phosphonate-bd PF12974.7 CDF37147.1 - 0.01 15.4 0.0 4 6.9 0.0 2.3 1 1 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein ESM4 PF15952.5 CDF37147.1 - 0.062 13.7 0.4 0.14 12.6 0.4 1.6 1 0 0 1 1 1 0 Enhancer of split M4 family Hint PF01079.20 CDF37150.1 - 1.3e-26 93.5 0.1 3.2e-26 92.2 0.1 1.5 1 1 0 1 1 1 1 Hint module PT-HINT PF07591.11 CDF37150.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Pretoxin HINT domain zf-H2C2_2 PF13465.6 CDF37157.1 - 4e-09 36.5 29.8 0.00045 20.5 0.2 5.9 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.26 CDF37157.1 - 5.6e-09 36.0 25.2 0.0069 16.8 1.1 4.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF37157.1 - 4.4e-06 27.1 30.2 0.026 15.3 1.2 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 CDF37157.1 - 0.0065 16.8 1.5 0.15 12.5 0.5 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 CDF37157.1 - 0.0079 15.9 0.7 0.0079 15.9 0.7 5.3 4 2 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 CDF37157.1 - 0.0093 16.6 9.0 0.11 13.2 4.2 2.9 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 CDF37157.1 - 8.7 6.7 13.8 40 4.6 8.9 2.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF92 PF01940.16 CDF37158.1 - 2.4e-63 213.7 5.4 2.9e-63 213.4 5.4 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 Bacteriocin_IIc PF10439.9 CDF37158.1 - 0.38 10.9 7.6 1.3 9.2 7.6 1.9 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Exo_endo_phos PF03372.23 CDF37159.1 - 3.4e-16 59.5 0.0 6e-16 58.7 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CDF37159.1 - 0.0094 15.8 0.0 0.057 13.3 0.0 2.2 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase zf-C3HC4_3 PF13920.6 CDF37161.1 - 2e-08 34.0 7.1 2e-08 34.0 7.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF37161.1 - 1.1e-07 31.6 7.5 1.1e-07 31.6 7.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF37161.1 - 8.2e-07 28.8 6.7 8.2e-07 28.8 6.7 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF37161.1 - 7.2e-06 26.2 8.3 7.2e-06 26.2 8.3 2.8 4 0 0 4 4 3 1 Ring finger domain zf-RING_5 PF14634.6 CDF37161.1 - 9.1e-05 22.3 6.2 9.1e-05 22.3 6.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF37161.1 - 0.00016 21.4 7.6 0.00072 19.4 7.6 2.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDF37161.1 - 0.0058 16.6 6.3 0.0058 16.6 6.3 2.8 2 1 1 3 3 3 1 RING-type zinc-finger Ribosomal_L36e PF01158.18 CDF37161.1 - 0.058 13.6 0.3 0.058 13.6 0.3 2.7 3 0 0 3 3 3 0 Ribosomal protein L36e zf-C2H2_jaz PF12171.8 CDF37161.1 - 0.058 13.7 0.0 0.058 13.7 0.0 2.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CDF37161.1 - 0.12 12.7 1.1 0.26 11.7 0.1 2.0 2 0 0 2 2 1 0 C2H2 type zinc-finger (2 copies) zf-C3HC4_4 PF15227.6 CDF37161.1 - 1.6 9.0 14.7 0.11 12.6 7.6 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 CDF37161.1 - 3.1 7.6 12.7 0.029 14.1 3.4 2.6 3 0 0 3 3 3 0 RING-like zinc finger AdoHcyase PF05221.17 CDF37163.1 - 2.5e-143 476.7 0.0 2.9e-143 476.5 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CDF37163.1 - 6.2e-80 267.0 3.0 9.5e-80 266.4 3.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDF37163.1 - 1.1e-09 38.0 0.4 1.8e-09 37.2 0.4 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CDF37163.1 - 1.7e-06 27.7 0.2 2.6e-06 27.1 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 CDF37163.1 - 0.00095 19.2 0.3 0.0022 18.1 0.3 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 CDF37163.1 - 0.0021 17.4 0.6 0.0045 16.3 0.6 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TrkA_N PF02254.18 CDF37163.1 - 0.0026 18.0 0.1 0.011 16.0 0.0 2.1 2 1 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.6 CDF37163.1 - 0.0049 17.3 0.2 0.011 16.1 0.2 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding ELFV_dehydrog PF00208.21 CDF37163.1 - 0.008 15.9 0.2 0.013 15.2 0.2 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Urocanase PF01175.18 CDF37163.1 - 0.064 12.9 0.4 0.11 12.2 0.4 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain OTCace PF00185.24 CDF37164.1 - 2.4e-46 157.7 0.0 4.1e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 CDF37164.1 - 6.7e-41 139.7 0.1 2.1e-40 138.2 0.0 1.7 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Glyco_hydro_101 PF12905.7 CDF37164.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.1 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase PAP_fibrillin PF04755.12 CDF37166.1 - 7.4e-08 32.6 0.0 0.0096 15.9 0.1 2.2 1 1 1 2 2 2 2 PAP_fibrillin UDPGP PF01704.18 CDF37168.1 - 7.9e-184 611.1 0.4 9.6e-184 610.8 0.4 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Spot_14 PF07084.12 CDF37168.1 - 0.024 14.8 0.5 0.05 13.7 0.5 1.4 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 DEAD_2 PF06733.15 CDF37169.1 - 7.8e-46 155.9 0.0 1.2e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 CDF37169.1 - 9.9e-43 146.3 0.0 3.2e-42 144.6 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain HBB PF06777.11 CDF37169.1 - 2.4e-16 60.0 0.8 2.6e-11 43.5 0.0 3.0 2 1 1 3 3 3 2 Helical and beta-bridge domain ResIII PF04851.15 CDF37169.1 - 1.1e-05 25.5 0.0 0.00032 20.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 CDF37169.1 - 0.0043 16.9 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 CDF37169.1 - 0.022 14.5 0.1 0.42 10.4 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_19 PF13245.6 CDF37169.1 - 0.047 14.0 0.1 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_34 PF13872.6 CDF37169.1 - 0.088 11.7 0.0 3.4 6.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 SNF2_N PF00176.23 CDF37169.1 - 0.12 11.0 0.0 2.1 7.0 0.0 2.3 1 1 0 1 1 1 0 SNF2 family N-terminal domain AfaD PF05775.12 CDF37169.1 - 0.13 12.7 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 Enterobacteria AfaD invasin protein AAA_22 PF13401.6 CDF37169.1 - 0.14 12.4 0.1 16 5.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain PALP PF00291.25 CDF37170.1 - 9.2e-48 163.1 1.7 1.1e-47 162.8 1.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SERTA PF06031.13 CDF37170.1 - 0.043 13.5 0.3 0.093 12.4 0.3 1.5 1 0 0 1 1 1 0 SERTA motif TehB PF03848.14 CDF37173.1 - 1.4e-06 27.9 0.0 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_11 PF08241.12 CDF37173.1 - 4.9e-05 23.9 0.1 0.0001 22.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF37173.1 - 6.8e-05 23.5 0.0 0.00018 22.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Rhodanese PF00581.20 CDF37173.1 - 0.00032 21.2 0.0 0.00059 20.3 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_23 PF13489.6 CDF37173.1 - 0.00033 20.5 0.1 0.00057 19.7 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF37173.1 - 0.0075 17.0 0.1 0.016 15.9 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain SAM_MT PF04445.13 CDF37173.1 - 0.068 12.6 0.1 0.09 12.2 0.1 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase PCMT PF01135.19 CDF37173.1 - 0.069 12.9 0.0 0.098 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CDF37173.1 - 0.11 12.3 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain UCH PF00443.29 CDF37174.1 - 1e-46 159.5 0.0 1.3e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF37174.1 - 6e-12 45.8 0.0 9.6e-12 45.1 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CDF37174.1 - 2.5e-06 27.2 0.1 0.00055 19.6 0.0 3.3 3 1 1 4 4 4 1 Ubiquitin family SRP54_N PF02881.19 CDF37175.1 - 0.03 14.5 0.3 1.7 8.9 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain DEAD PF00270.29 CDF37177.1 - 5.8e-48 163.0 0.0 1.1e-47 162.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF37177.1 - 1.6e-28 99.3 0.0 6.7e-28 97.2 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF37177.1 - 0.00042 20.4 0.0 0.00088 19.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_M50 PF02163.22 CDF37179.1 - 7.2e-05 22.2 1.3 0.00013 21.4 0.7 1.6 1 1 0 1 1 1 1 Peptidase family M50 ABC_tran PF00005.27 CDF37182.1 - 1.2e-15 58.2 0.0 1.5e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CDF37182.1 - 6.3e-05 22.6 0.1 0.00012 21.7 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF37182.1 - 0.00011 22.6 0.0 0.00012 22.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDF37182.1 - 0.00032 21.0 0.0 0.00044 20.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF37182.1 - 0.00045 20.0 0.0 0.00059 19.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 CDF37182.1 - 0.00045 20.2 0.0 0.00063 19.7 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_21 PF13304.6 CDF37182.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDF37182.1 - 0.003 17.5 0.0 0.0041 17.0 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 CDF37182.1 - 0.0057 16.8 0.0 0.0075 16.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDF37182.1 - 0.0068 16.9 0.0 0.011 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF37182.1 - 0.0091 16.5 0.0 0.012 16.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_27 PF13514.6 CDF37182.1 - 0.018 14.6 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDF37182.1 - 0.023 14.6 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ATP_bind_2 PF03668.15 CDF37182.1 - 0.042 13.2 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 P-loop ATPase protein family NTPase_1 PF03266.15 CDF37182.1 - 0.053 13.4 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA PF00004.29 CDF37182.1 - 0.09 13.2 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 CDF37182.1 - 0.093 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase T2SSE PF00437.20 CDF37182.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 CDF37182.1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDF37182.1 - 0.17 11.9 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CDF37182.1 - 0.2 12.1 0.0 0.5 10.8 0.0 1.6 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDF37182.1 - 0.26 10.6 0.0 0.38 10.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin DUF647 PF04884.14 CDF37185.1 - 8.5e-71 238.4 0.1 1.1e-70 238.1 0.1 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis PHD PF00628.29 CDF37186.1 - 1.7e-09 37.4 8.3 3.3e-09 36.5 8.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CDF37186.1 - 1.5e-05 24.4 4.2 3e-05 23.5 4.2 1.5 1 0 0 1 1 1 1 PHD-finger Ribosomal_S8e PF01201.22 CDF37189.1 - 9.7e-53 178.0 0.1 1.2e-52 177.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e RPN2_C PF18004.1 CDF37190.1 - 3.2e-31 108.4 4.5 3.2e-31 108.4 4.5 2.1 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 CDF37190.1 - 1.2e-20 72.8 26.7 4.6e-06 26.8 0.0 9.5 9 0 0 9 9 9 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CDF37190.1 - 5.1e-16 58.8 0.4 2.2e-12 47.2 0.0 3.8 2 1 2 4 4 4 2 HEAT repeats HEAT PF02985.22 CDF37190.1 - 2.8e-05 24.0 0.9 2.7 8.5 0.2 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 CDF37190.1 - 0.0035 17.8 2.7 0.41 11.2 0.1 3.7 2 1 2 4 4 4 2 HEAT-like repeat RCC1 PF00415.18 CDF37191.1 - 3.5e-46 155.6 6.2 5e-12 46.3 0.2 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDF37191.1 - 1.8e-17 62.6 15.0 3e-08 33.2 0.2 5.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat SRP54 PF00448.22 CDF37193.1 - 7.5e-73 244.4 2.2 7.5e-73 244.4 2.2 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CDF37193.1 - 2.3e-25 89.1 4.3 2.3e-25 89.1 4.3 3.6 4 0 0 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 CDF37193.1 - 1.3e-15 57.3 7.2 2.9e-13 49.8 0.3 3.9 4 0 0 4 4 3 1 SRP54-type protein, helical bundle domain Zeta_toxin PF06414.12 CDF37193.1 - 1.1e-06 28.0 0.1 2.3e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Zeta toxin CbiA PF01656.23 CDF37193.1 - 3.7e-05 23.8 0.5 9.8e-05 22.4 0.5 1.8 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 CDF37193.1 - 0.00018 21.3 0.1 0.00039 20.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 CDF37193.1 - 0.00031 20.4 1.8 0.00089 18.9 1.8 1.8 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 CDF37193.1 - 0.0018 17.9 0.7 0.0051 16.4 0.7 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain APS_kinase PF01583.20 CDF37193.1 - 0.0029 17.5 0.0 0.012 15.6 0.0 2.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CDF37193.1 - 0.003 17.7 0.0 0.0073 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF37193.1 - 0.0078 16.6 0.1 0.018 15.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 CDF37193.1 - 0.0086 15.4 2.1 0.0094 15.3 0.3 2.0 2 0 0 2 2 2 1 KaiC AAA_30 PF13604.6 CDF37193.1 - 0.0099 15.6 3.7 0.02 14.6 2.3 2.3 1 1 2 3 3 3 1 AAA domain AAA_22 PF13401.6 CDF37193.1 - 0.018 15.3 0.1 0.13 12.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDF37193.1 - 0.026 14.1 1.7 0.091 12.3 1.7 1.9 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDF37193.1 - 0.027 14.5 2.9 0.099 12.7 0.9 2.9 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA PF00004.29 CDF37193.1 - 0.029 14.8 0.4 1 9.8 0.2 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 CDF37193.1 - 0.039 13.9 0.3 0.16 11.9 0.2 2.1 1 1 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.15 CDF37193.1 - 0.039 13.1 0.1 0.039 13.1 0.1 2.6 3 0 0 3 3 3 0 Anion-transporting ATPase AAA_18 PF13238.6 CDF37193.1 - 0.09 13.3 0.1 0.29 11.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 CDF37193.1 - 0.097 12.7 0.1 0.25 11.3 0.1 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit KTI12 PF08433.10 CDF37193.1 - 0.19 11.2 0.7 0.44 9.9 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Thymidylate_kin PF02223.17 CDF37193.1 - 0.29 10.8 2.9 0.77 9.4 0.0 2.5 3 0 0 3 3 2 0 Thymidylate kinase GSHPx PF00255.19 CDF37194.1 - 1.3e-17 63.3 0.0 1.9e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Glycos_transf_2 PF00535.26 CDF37195.1 - 3.1e-19 69.4 0.0 4.5e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDF37195.1 - 9.6e-13 48.6 0.2 1.4e-12 48.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDF37195.1 - 0.017 14.6 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CDF37195.1 - 0.024 15.1 0.0 0.049 14.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 bZIP_1 PF00170.21 CDF37196.1 - 0.0001 22.3 9.1 0.0001 22.3 9.1 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CDF37196.1 - 0.00049 20.1 14.1 0.00051 20.1 12.5 1.8 2 0 0 2 2 2 1 Basic region leucine zipper PilJ PF13675.6 CDF37196.1 - 0.021 14.9 2.2 0.036 14.1 0.9 1.8 1 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1515 PF07439.11 CDF37196.1 - 0.051 13.6 1.7 0.096 12.7 1.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) bZIP_Maf PF03131.17 CDF37196.1 - 1 9.9 9.7 2 9.0 9.4 1.6 1 1 0 1 1 1 0 bZIP Maf transcription factor PI-PLC-X PF00388.19 CDF37198.1 - 6.9e-56 187.9 0.0 2e-55 186.4 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CDF37198.1 - 2.9e-24 85.6 0.0 6.9e-24 84.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 CDF37198.1 - 8.1e-13 48.5 0.0 2e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 C2 domain Creatinase_N_2 PF16189.5 CDF37200.1 - 5.2e-50 169.7 0.0 8.1e-50 169.1 0.0 1.3 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CDF37200.1 - 1.7e-44 152.0 0.0 2.8e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 CDF37200.1 - 8.8e-22 76.9 0.4 2.1e-21 75.7 0.4 1.7 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CDF37200.1 - 8.5e-07 29.7 0.0 0.065 13.9 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Pribosyltran PF00156.27 CDF37202.1 - 5.5e-19 68.2 0.0 7.5e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDF37202.1 - 3.1e-05 23.5 0.0 9.4e-05 21.9 0.1 1.6 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 CDF37202.1 - 0.077 12.5 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase ubiquitin PF00240.23 CDF37203.1 - 8.2e-12 44.7 0.0 1.4e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CDF37203.1 - 1.4e-06 28.1 0.1 9e-06 25.5 0.1 2.6 1 0 0 1 1 1 1 UBA/TS-N domain STI1 PF17830.1 CDF37203.1 - 3.8e-05 23.5 64.0 0.004 17.1 10.0 6.1 3 2 1 5 5 5 3 STI1 domain Rad60-SLD PF11976.8 CDF37203.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDF37203.1 - 0.00061 20.2 0.1 0.0032 17.9 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-like domain HOIP-UBA PF16678.5 CDF37203.1 - 0.00064 19.7 0.1 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 HOIP UBA domain pair CUE PF02845.16 CDF37203.1 - 0.0057 16.3 1.5 0.035 13.8 0.1 3.0 2 0 0 2 2 2 1 CUE domain TBK1_ULD PF18396.1 CDF37203.1 - 0.017 15.0 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDF37203.1 - 0.017 15.2 0.0 0.048 13.8 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Elf4 PF07011.11 CDF37203.1 - 0.15 12.0 0.3 0.33 10.9 0.3 1.6 1 0 0 1 1 1 0 Early Flowering 4 domain LPD22 PF18834.1 CDF37203.1 - 0.41 10.9 6.8 10 6.4 0.2 3.9 3 1 1 4 4 4 0 Large polyvalent protein associated domain 22 EthD PF07110.11 CDF37203.1 - 1.3 10.2 5.0 1.6 10.0 0.1 3.4 4 1 0 4 4 3 0 EthD domain BRO1 PF03097.18 CDF37204.1 - 1.2e-40 139.6 0.0 1.7e-40 139.1 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CDF37204.1 - 3.4e-25 88.9 0.1 6.6e-25 88.0 0.1 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV PP-binding PF00550.25 CDF37205.1 - 2.6e-11 43.7 0.1 3.5e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CDF37205.1 - 0.005 17.0 0.1 0.0072 16.5 0.1 1.2 1 0 0 1 1 1 1 Acyl-carrier vATP-synt_E PF01991.18 CDF37206.1 - 1.5e-59 200.8 3.1 1.7e-59 200.6 3.1 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Afaf PF15339.6 CDF37206.1 - 0.045 13.5 1.6 0.062 13.0 1.6 1.1 1 0 0 1 1 1 0 Acrosome formation-associated factor DUF3535 PF12054.8 CDF37206.1 - 1.4 8.1 6.7 2 7.6 5.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3535) AAA PF00004.29 CDF37207.1 - 5.3e-41 140.1 0.0 8.7e-29 100.6 0.0 3.7 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.25 CDF37207.1 - 2.7e-15 56.2 0.1 5.8e-15 55.1 0.1 1.6 1 0 0 1 1 1 1 Bromodomain AAA_lid_3 PF17862.1 CDF37207.1 - 1.4e-11 44.0 1.5 1.8e-11 43.7 0.1 1.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_2 PF07724.14 CDF37207.1 - 0.00047 20.3 0.0 0.075 13.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDF37207.1 - 0.00049 20.5 0.5 0.027 14.9 0.0 3.5 4 0 0 4 4 4 1 AAA ATPase domain AAA_5 PF07728.14 CDF37207.1 - 0.0024 17.9 0.1 0.3 11.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF37207.1 - 0.0043 17.3 0.1 0.18 12.1 0.0 3.4 4 0 0 4 4 4 1 AAA domain Sigma54_activ_2 PF14532.6 CDF37207.1 - 0.057 13.5 0.0 0.23 11.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain RuvB_N PF05496.12 CDF37207.1 - 0.072 12.8 0.1 0.38 10.5 0.0 2.2 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDF37207.1 - 0.073 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CDF37207.1 - 0.088 13.4 0.0 0.33 11.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF37207.1 - 0.16 11.5 0.0 0.4 10.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CDF37207.1 - 0.16 12.3 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 CDF37207.1 - 0.19 11.4 0.3 0.78 9.4 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein HAD PF12710.7 CDF37208.1 - 3e-13 50.6 0.0 6.7e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF37208.1 - 2.3e-09 37.8 0.6 9.2e-09 35.9 0.6 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ACT_6 PF13740.6 CDF37208.1 - 4.6e-07 29.7 0.3 5.2e-06 26.4 0.2 2.4 2 0 0 2 2 2 1 ACT domain Put_Phosphatase PF06888.12 CDF37208.1 - 0.002 17.6 0.0 0.0041 16.5 0.0 1.6 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.6 CDF37208.1 - 0.003 17.7 0.0 0.02 15.0 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Phage_DsbA PF11126.8 CDF37208.1 - 0.0041 17.3 0.0 0.48 10.7 0.0 2.7 2 0 0 2 2 2 1 Transcriptional regulator DsbA Hydrolase_3 PF08282.12 CDF37208.1 - 0.0063 16.3 0.1 0.01 15.6 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Yop-YscD_cpl PF16697.5 CDF37208.1 - 0.12 12.7 0.2 0.34 11.3 0.1 1.7 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain Cupin_8 PF13621.6 CDF37209.1 - 6.2e-23 81.8 0.0 2.6e-16 60.1 0.0 2.3 2 0 0 2 2 2 2 Cupin-like domain JmjC PF02373.22 CDF37209.1 - 1.7e-13 51.0 0.0 1.3e-12 48.1 0.0 2.4 2 1 0 2 2 2 1 JmjC domain, hydroxylase F-box-like PF12937.7 CDF37209.1 - 0.01 15.7 1.0 0.032 14.1 0.2 2.2 2 0 0 2 2 2 1 F-box-like Cupin_2 PF07883.11 CDF37209.1 - 0.013 15.2 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Cupin_4 PF08007.12 CDF37209.1 - 0.019 14.4 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein Cupin_1 PF00190.22 CDF37209.1 - 0.089 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Cupin GRIP PF01465.20 CDF37210.1 - 3.4e-09 36.5 0.0 8.6e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 GRIP domain Spc7 PF08317.11 CDF37210.1 - 0.00062 18.8 91.0 0.03 13.2 13.9 5.4 2 1 3 6 6 6 6 Spc7 kinetochore protein DASH_Hsk3 PF08227.11 CDF37210.1 - 0.0047 17.3 0.6 0.0047 17.3 0.6 4.0 5 0 0 5 5 5 1 DASH complex subunit Hsk3 like DUF4094 PF13334.6 CDF37210.1 - 0.0057 17.1 1.4 0.0057 17.1 1.4 7.3 7 2 1 8 8 8 3 Domain of unknown function (DUF4094) Pox_A_type_inc PF04508.12 CDF37210.1 - 0.27 11.2 0.0 0.27 11.2 0.0 5.6 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat sCache_like PF16736.5 CDF37210.1 - 8.4 6.5 14.4 0.38 10.8 5.7 3.1 1 1 1 2 2 2 0 Single Cache-like p450 PF00067.22 CDF37211.1 - 1.3e-66 225.2 0.0 1.7e-66 224.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tudor_3 PF18115.1 CDF37213.1 - 0.066 13.1 0.0 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain LBR_tudor PF09465.10 CDF37213.1 - 0.099 12.5 1.4 3.4 7.5 0.0 3.2 3 0 0 3 3 3 0 Lamin-B receptor of TUDOR domain TPT PF03151.16 CDF37214.1 - 4.8e-09 36.0 21.7 2.2e-08 33.8 21.8 1.7 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 CDF37214.1 - 0.00056 20.1 35.0 0.061 13.5 12.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF2457 PF10446.9 CDF37216.1 - 1.2 8.2 6.7 1.3 8.1 6.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pkinase PF00069.25 CDF37217.1 - 2.5e-18 66.4 0.0 2.2e-17 63.3 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37217.1 - 7.4e-16 58.2 0.0 1.1e-06 28.2 0.0 3.1 3 1 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 CDF37217.1 - 0.0016 17.9 0.0 0.0042 16.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Trypsin_2 PF13365.6 CDF37218.1 - 2.8e-19 70.5 0.2 4.7e-19 69.8 0.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDF37218.1 - 1.8e-11 44.3 0.1 2.7e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 CDF37218.1 - 0.022 13.5 0.8 0.46 9.1 0.5 2.1 1 1 1 2 2 2 0 Peptidase S46 Peptidase_S7 PF00949.21 CDF37218.1 - 0.048 13.5 0.1 0.14 12.0 0.1 1.9 1 1 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Blt1_C PF17183.4 CDF37218.1 - 0.097 12.3 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Get5 carboxyl domain PDZ_3 PF17815.1 CDF37219.1 - 1.8e-35 121.9 0.0 2.6e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDF37219.1 - 3.3e-05 24.1 0.1 0.00031 21.0 0.0 2.3 2 1 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 CDF37219.1 - 8.8e-05 22.3 0.2 0.29 11.0 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CDF37219.1 - 0.027 14.8 0.0 0.068 13.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Rad60-SLD PF11976.8 CDF37220.1 - 8.7e-10 38.3 0.0 2.4e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDF37220.1 - 0.088 12.6 0.1 0.2 11.4 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin family Glyco_tran_28_C PF04101.16 CDF37220.1 - 0.18 11.8 4.7 0.38 10.7 4.7 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain RBR PF17208.3 CDF37220.1 - 0.81 10.4 6.0 9.2 7.1 7.2 2.2 1 1 1 2 2 2 0 RNA binding Region RR_TM4-6 PF06459.12 CDF37220.1 - 2.4 7.9 10.9 3.6 7.4 10.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TRAM_LAG1_CLN8 PF03798.16 CDF37222.1 - 2.2e-25 89.5 20.9 4.1e-25 88.7 20.9 1.5 1 1 0 1 1 1 1 TLC domain DAO PF01266.24 CDF37224.1 - 1.8e-21 77.1 0.1 2.2e-21 76.8 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase TFIIE_alpha PF02002.17 CDF37226.1 - 2.3e-09 37.1 0.7 6.4e-09 35.6 0.3 2.0 2 0 0 2 2 2 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 CDF37226.1 - 3.7e-07 30.3 4.8 5.4e-06 26.6 0.2 2.7 2 0 0 2 2 2 2 C-terminal general transcription factor TFIIE alpha ABC1 PF03109.16 CDF37228.1 - 1.2e-35 122.2 0.1 2.9e-35 121.0 0.1 1.7 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 CDF37228.1 - 0.0021 18.0 0.2 0.028 14.4 0.2 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF37228.1 - 0.0099 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Sad1_UNC PF07738.13 CDF37230.1 - 2e-20 73.2 0.1 7.3e-20 71.3 0.0 1.9 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal Waikav_capsid_1 PF12264.8 CDF37230.1 - 0.031 13.8 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Waikavirus capsid protein 1 HTH_Tnp_Tc3_1 PF11427.8 CDF37231.1 - 2.8e-07 30.3 0.0 4.9e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF37231.1 - 4.5e-07 29.5 0.0 9.7e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF37231.1 - 1.1e-06 28.2 1.2 2.8e-06 27.0 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_N PF04218.13 CDF37231.1 - 0.0059 16.2 0.2 0.45 10.2 0.1 2.2 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc3_2 PF01498.18 CDF37231.1 - 0.006 16.8 3.0 0.0079 16.4 0.8 2.1 1 1 1 2 2 2 1 Transposase DDE_3 PF13358.6 CDF37231.1 - 0.01 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_Tnp_ISL3 PF13542.6 CDF37231.1 - 0.03 13.7 0.0 0.073 12.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_29 PF13551.6 CDF37231.1 - 0.049 13.7 0.3 0.14 12.2 0.1 1.9 2 0 0 2 2 2 0 Winged helix-turn helix HTH_24 PF13412.6 CDF37231.1 - 0.055 13.0 0.3 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding PAX PF00292.18 CDF37231.1 - 0.12 12.3 0.1 0.26 11.2 0.0 1.6 1 1 0 1 1 1 0 'Paired box' domain HTH_IclR PF09339.10 CDF37231.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_35 PF13693.6 CDF37231.1 - 0.14 12.2 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Aminotran_5 PF00266.19 CDF37234.1 - 9.3e-37 126.8 0.0 1.2e-36 126.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V RVT_3 PF13456.6 CDF37235.1 - 0.022 14.6 0.1 0.084 12.7 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like Plus-3 PF03126.18 CDF37236.1 - 4.4e-18 65.8 0.0 1.2e-17 64.4 0.0 1.7 2 0 0 2 2 2 1 Plus-3 domain BHD_3 PF10405.9 CDF37238.1 - 2e-23 82.6 0.0 4.4e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 CDF37238.1 - 5.1e-16 58.2 3.0 5.9e-16 58.1 1.4 2.0 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 CDF37238.1 - 1.3e-08 34.7 6.6 0.00031 20.5 0.0 3.1 3 0 0 3 3 3 2 Rad4 transglutaminase-like domain Transglut_core PF01841.19 CDF37238.1 - 5.6e-08 33.2 0.0 2e-07 31.5 0.0 2.0 1 0 0 1 1 1 1 Transglutaminase-like superfamily BHD_2 PF10404.9 CDF37238.1 - 0.00041 21.2 0.9 0.00041 21.2 0.9 5.4 4 2 0 5 5 5 1 Rad4 beta-hairpin domain 2 UNC-79 PF14776.6 CDF37238.1 - 0.21 10.3 0.7 0.37 9.5 0.7 1.3 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 FmiP_Thoc5 PF09766.9 CDF37238.1 - 2.5 7.3 12.4 0.016 14.5 2.3 2.1 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 TcdA_TcdB_pore PF12920.7 CDF37239.1 - 1.9 6.6 4.2 2.5 6.3 4.2 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain BRK PF07533.16 CDF37240.1 - 0.19 11.4 0.0 0.55 9.9 0.0 1.7 2 0 0 2 2 2 0 BRK domain SelR PF01641.18 CDF37242.1 - 7.4e-46 155.2 0.2 9.2e-46 154.9 0.2 1.1 1 0 0 1 1 1 1 SelR domain zf-Mss51 PF13824.6 CDF37242.1 - 0.052 13.7 1.3 0.085 13.0 0.3 2.0 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Ribosomal_L37e PF01907.19 CDF37242.1 - 2.6 8.3 9.3 0.1 12.7 1.3 2.5 3 0 0 3 3 3 0 Ribosomal protein L37e KH_6 PF15985.5 CDF37243.1 - 4.3e-14 52.6 0.1 7.3e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 CDF37243.1 - 3.5e-06 26.8 0.2 9.7e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain LRR_8 PF13855.6 CDF37245.1 - 0.00066 19.4 1.0 0.0018 18.0 0.8 1.9 1 1 1 2 2 2 2 Leucine rich repeat DNA_photolyase PF00875.18 CDF37246.1 - 3.8e-44 150.6 0.0 6.8e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase Usp PF00582.26 CDF37246.1 - 0.11 13.0 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 Universal stress protein family PolyA_pol_RNAbd PF12627.7 CDF37246.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A Longin PF13774.6 CDF37247.1 - 6e-14 51.8 0.0 1.4e-13 50.6 0.0 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 CDF37247.1 - 1.2e-10 41.0 0.8 1.9e-10 40.3 0.8 1.3 1 0 0 1 1 1 1 Synaptobrevin FAE1_CUT1_RppA PF08392.12 CDF37249.1 - 2.5e-105 351.9 1.2 8.2e-89 297.7 0.8 2.1 1 1 1 2 2 2 2 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 CDF37249.1 - 2.5e-12 46.8 0.0 6.1e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 CDF37249.1 - 2.6e-08 34.0 0.0 5.9e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 CDF37249.1 - 2.2e-05 24.0 0.0 3.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 CDF37249.1 - 0.0012 18.7 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Actin PF00022.19 CDF37250.1 - 2.3e-34 118.7 0.0 1.3e-17 63.5 0.0 2.8 2 1 0 2 2 2 2 Actin PilM_2 PF11104.8 CDF37250.1 - 0.0046 16.0 0.0 0.0079 15.3 0.0 1.3 1 0 0 1 1 1 1 Type IV pilus assembly protein PilM; WD40 PF00400.32 CDF37251.1 - 0.00019 22.2 2.4 0.00098 19.9 0.6 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF37251.1 - 0.0073 16.6 0.2 0.87 9.9 0.1 2.6 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain LPAM_2 PF13627.6 CDF37251.1 - 0.098 12.5 0.2 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Aegerolysin PF06355.13 CDF37251.1 - 0.16 12.1 1.2 15 5.7 0.0 2.6 2 1 1 3 3 3 0 Aegerolysin CpcD PF01383.21 CDF37252.1 - 2.5e-10 40.5 0.4 5.4e-10 39.4 0.2 1.7 1 1 1 2 2 2 1 CpcD/allophycocyanin linker domain AAA_6 PF12774.7 CDF37253.1 - 2.8e-100 335.5 0.0 5.2e-100 334.6 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 CDF37253.1 - 1.5e-51 175.2 0.0 8.4e-50 169.5 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 CDF37253.1 - 4.5e-39 133.6 0.0 2.9e-13 50.0 0.0 5.7 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) DHC_N2 PF08393.13 CDF37253.1 - 4.1e-38 131.5 0.0 4.1e-38 131.5 0.0 2.9 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 CDF37253.1 - 7.6e-34 116.8 0.0 1.7e-32 112.4 0.0 2.7 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 CDF37253.1 - 2.8e-32 111.7 0.0 1.2e-23 83.6 0.0 4.9 6 0 0 6 6 6 2 P-loop containing dynein motor region MT PF12777.7 CDF37253.1 - 5.3e-25 88.2 2.6 7.9e-25 87.6 2.6 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA PF00004.29 CDF37253.1 - 4.5e-17 62.7 0.1 0.0002 21.8 0.0 5.1 5 0 0 5 5 4 3 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDF37253.1 - 1e-11 45.5 0.0 0.18 12.4 0.0 5.1 4 0 0 4 4 4 3 AAA domain AAA_16 PF13191.6 CDF37253.1 - 2.9e-10 40.8 14.6 0.046 14.1 0.1 8.5 7 2 2 9 9 9 2 AAA ATPase domain AAA_22 PF13401.6 CDF37253.1 - 5.8e-10 39.6 14.5 0.002 18.4 0.0 6.6 6 1 0 6 6 4 2 AAA domain AAA_33 PF13671.6 CDF37253.1 - 2e-08 34.5 0.5 0.19 11.9 0.0 5.1 4 0 0 4 4 4 2 AAA domain IstB_IS21 PF01695.17 CDF37253.1 - 1.4e-06 28.2 0.9 0.2 11.4 0.0 4.7 5 0 0 5 5 5 2 IstB-like ATP binding protein RNA_helicase PF00910.22 CDF37253.1 - 2.7e-06 27.7 0.0 1.8 9.0 0.0 4.5 4 0 0 4 4 4 1 RNA helicase Mg_chelatase PF01078.21 CDF37253.1 - 2.8e-06 26.9 0.5 0.39 10.1 0.0 4.5 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 CDF37253.1 - 1.7e-05 25.4 2.5 0.58 10.7 0.0 4.9 5 0 0 5 5 4 1 ABC transporter RuvB_N PF05496.12 CDF37253.1 - 1.8e-05 24.5 0.1 0.0024 17.6 0.0 3.5 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 CDF37253.1 - 3.1e-05 23.8 0.1 0.35 10.6 0.0 4.4 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 CDF37253.1 - 3.6e-05 23.0 0.2 0.31 10.1 0.0 4.0 4 0 0 4 4 3 1 Type II/IV secretion system protein Sigma54_activat PF00158.26 CDF37253.1 - 8.1e-05 22.4 0.0 0.061 13.0 0.0 3.7 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_29 PF13555.6 CDF37253.1 - 8.2e-05 22.3 0.0 0.06 13.1 0.0 3.7 4 0 0 4 4 3 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDF37253.1 - 8.8e-05 22.5 0.0 0.31 10.9 0.0 3.5 3 0 0 3 3 3 1 RsgA GTPase AAA_30 PF13604.6 CDF37253.1 - 0.00012 21.8 7.6 3.8 7.2 0.0 5.2 5 0 0 5 5 5 1 AAA domain AAA_3 PF07726.11 CDF37253.1 - 0.00017 21.4 0.0 0.31 10.9 0.0 3.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CDF37253.1 - 0.0002 21.3 0.1 5.4 6.9 0.0 4.3 4 0 0 4 4 4 0 Rad17 P-loop domain AAA_25 PF13481.6 CDF37253.1 - 0.00029 20.5 0.0 0.32 10.5 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 CDF37253.1 - 0.00066 20.0 4.2 33 4.8 0.0 5.7 5 1 0 5 5 5 0 AAA domain TPR_MLP1_2 PF07926.12 CDF37253.1 - 0.0026 17.8 9.3 0.0026 17.8 9.3 3.6 3 0 0 3 3 3 1 TPR/MLP1/MLP2-like protein AAA_28 PF13521.6 CDF37253.1 - 0.0056 16.9 6.0 39 4.5 0.0 5.1 5 0 0 5 5 4 0 AAA domain Zeta_toxin PF06414.12 CDF37253.1 - 0.011 15.0 3.3 0.82 8.9 0.0 3.6 5 0 0 5 5 4 0 Zeta toxin AAA_lid_7 PF17867.1 CDF37253.1 - 0.014 15.6 0.1 0.13 12.5 0.0 2.6 2 0 0 2 2 2 0 Midasin AAA lid domain Sigma54_activ_2 PF14532.6 CDF37253.1 - 0.015 15.4 0.0 3.2 7.9 0.0 3.9 4 0 0 4 4 4 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 CDF37253.1 - 0.02 14.7 0.0 3.4 7.3 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 CDF37253.1 - 0.028 14.3 2.3 4.5 7.2 0.0 3.9 4 0 0 4 4 3 0 NACHT domain Guanylate_kin PF00625.21 CDF37253.1 - 0.034 13.8 0.2 1.8 8.2 0.0 3.1 3 0 0 3 3 2 0 Guanylate kinase AAA_17 PF13207.6 CDF37253.1 - 0.046 14.1 0.1 44 4.5 0.0 4.4 4 0 0 4 4 4 0 AAA domain FtsK_SpoIIIE PF01580.18 CDF37253.1 - 0.05 12.9 0.1 1.8 7.9 0.0 3.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CDF37253.1 - 0.094 12.8 0.0 24 5.1 0.0 3.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase cobW PF02492.19 CDF37253.1 - 0.11 12.1 0.3 4.9 6.7 0.0 2.9 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain ResIII PF04851.15 CDF37253.1 - 0.16 11.9 0.8 0.54 10.2 0.0 2.3 3 0 0 3 3 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 CDF37253.1 - 2.3 8.7 11.9 11 6.5 0.0 5.1 6 0 0 6 6 4 0 AAA domain ERM PF00769.19 CDF37253.1 - 6.2 6.6 29.7 0.045 13.6 6.7 2.8 3 0 0 3 3 2 0 Ezrin/radixin/moesin family NMD3 PF04981.13 CDF37255.1 - 7.7e-78 261.3 5.4 1.1e-77 260.9 5.4 1.2 1 0 0 1 1 1 1 NMD3 family HNHc_6 PF16784.5 CDF37255.1 - 0.0074 15.9 0.2 0.013 15.1 0.2 1.4 1 0 0 1 1 1 1 Putative HNHc nuclease DUF1289 PF06945.13 CDF37255.1 - 0.34 10.7 5.5 1.1 9.1 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) Abi_2 PF07751.11 CDF37256.1 - 0.094 13.0 0.0 0.1 12.9 0.0 1.0 1 0 0 1 1 1 0 Abi-like protein Hydrolase_4 PF12146.8 CDF37257.1 - 2.4e-41 141.6 0.0 3.2e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDF37257.1 - 2.5e-11 44.6 0.1 3.8e-11 44.0 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDF37257.1 - 3.4e-07 30.0 0.0 0.00027 20.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDF37257.1 - 1.4e-06 28.2 0.1 0.017 14.7 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDF37257.1 - 0.00032 20.6 0.2 4.2 7.1 0.0 3.1 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 CDF37257.1 - 0.0017 18.0 0.0 0.003 17.3 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 CDF37257.1 - 0.028 14.5 0.0 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 TAP-like protein Cutinase PF01083.22 CDF37257.1 - 0.028 14.4 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 Cutinase Peptidase_S10 PF00450.22 CDF37257.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Serine carboxypeptidase DLH PF01738.18 CDF37257.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF2505 PF10698.9 CDF37258.1 - 6.9e-10 39.3 0.0 9.2e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) GST_N PF02798.20 CDF37259.1 - 6.2e-17 61.7 0.0 1.3e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDF37259.1 - 2.1e-12 47.1 0.1 8.8e-12 45.1 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CDF37259.1 - 3e-12 46.7 0.0 5.5e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDF37259.1 - 4.8e-12 46.1 0.0 9e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDF37259.1 - 2.6e-10 40.4 0.2 1e-08 35.2 0.2 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDF37259.1 - 1.2e-05 25.3 0.0 2.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4033 PF13225.6 CDF37261.1 - 6.1e-29 99.9 0.6 2.4e-28 97.9 0.6 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4033) Hydantoinase_A PF01968.18 CDF37262.1 - 0.057 12.7 0.0 0.068 12.4 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Cpn10 PF00166.21 CDF37263.1 - 4e-51 171.1 0.9 2.4e-24 85.2 0.0 2.0 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit Sulfotransfer_2 PF03567.14 CDF37265.1 - 7.4e-07 29.3 0.1 1.2e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 Sulfotransferase family Treslin_N PF15292.6 CDF37265.1 - 0.086 11.2 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Treslin N-terminus SecA_DEAD PF07517.14 CDF37267.1 - 1.5e-93 313.3 0.4 7.5e-93 311.0 0.2 2.0 2 0 0 2 2 2 1 SecA DEAD-like domain SecA_SW PF07516.13 CDF37267.1 - 1.4e-41 142.8 4.6 3.8e-41 141.4 4.6 1.8 1 0 0 1 1 1 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 CDF37267.1 - 5.3e-32 110.8 0.1 1.9e-31 109.0 0.1 2.1 1 0 0 1 1 1 1 SecA preprotein cross-linking domain DEAD PF00270.29 CDF37267.1 - 1.1e-06 28.5 0.0 3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF37267.1 - 0.023 15.0 0.5 4.4 7.7 0.0 3.8 4 0 0 4 4 4 0 Helicase conserved C-terminal domain Lys-AminoMut_A PF09043.11 CDF37267.1 - 0.031 12.7 0.0 0.062 11.7 0.0 1.4 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit Mito_carr PF00153.27 CDF37268.1 - 6.6e-71 234.3 0.5 1.1e-22 79.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDF37268.1 - 0.031 13.4 0.0 0.26 10.4 0.0 2.4 3 0 0 3 3 3 0 Gammaproteobacterial serine protease DHHC PF01529.20 CDF37270.1 - 9.2e-34 116.4 5.2 1.2e-33 116.0 5.2 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF899 PF05988.12 CDF37270.1 - 0.34 10.4 2.0 0.53 9.8 2.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) Plant_tran PF04827.14 CDF37271.1 - 1.5e-78 263.1 0.0 2e-78 262.7 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF37271.1 - 1.6e-14 53.9 0.0 2.7e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_tranf_2_3 PF13641.6 CDF37271.1 - 0.017 15.0 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase like family 2 ABC_membrane_2 PF06472.15 CDF37271.1 - 0.058 12.8 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 DDE_Tnp_1_2 PF13586.6 CDF37271.1 - 0.095 13.1 0.1 0.21 12.0 0.1 1.5 1 0 0 1 1 1 0 Transposase DDE domain ANTAR PF03861.14 CDF37271.1 - 0.14 12.0 0.5 0.38 10.6 0.0 1.9 2 0 0 2 2 2 0 ANTAR domain Circo_capsid PF02443.15 CDF37275.1 - 0.1 12.1 8.0 0.11 12.1 8.0 1.0 1 0 0 1 1 1 0 Circovirus capsid protein ApbE PF02424.15 CDF37276.1 - 2.4e-37 128.9 0.1 8.6e-37 127.1 0.0 1.9 2 0 0 2 2 2 1 ApbE family Flavin_Reduct PF01613.18 CDF37276.1 - 2.1e-08 34.3 1.2 2.1e-08 34.3 1.2 2.9 3 1 0 3 3 3 1 Flavin reductase like domain NB-ARC PF00931.22 CDF37277.1 - 1.2e-19 70.5 0.1 2.4e-19 69.5 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain TIR_2 PF13676.6 CDF37277.1 - 6.9e-16 58.9 0.0 2.6e-15 57.1 0.0 2.0 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF37277.1 - 4.8e-13 49.2 11.9 0.1 12.9 0.0 9.6 6 3 3 10 10 10 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF37277.1 - 3.2e-10 40.4 14.7 0.13 13.2 0.0 8.6 9 0 0 9 9 9 3 WD domain, G-beta repeat TIR PF01582.20 CDF37277.1 - 9.7e-08 32.0 0.0 3.2e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 TIR domain PQQ_2 PF13360.6 CDF37277.1 - 0.00067 19.3 21.7 0.0046 16.6 15.5 4.0 2 1 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 CDF37277.1 - 0.007 16.2 9.7 0.43 10.6 0.1 5.4 5 0 0 5 5 5 1 PQQ enzyme repeat APAF1_C PF17908.1 CDF37277.1 - 0.018 15.0 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain PD40 PF07676.12 CDF37277.1 - 0.51 10.3 9.3 58 3.8 0.1 6.1 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Cytomega_UL20A PF05984.12 CDF37279.1 - 0.078 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein GSDH PF07995.11 CDF37281.1 - 0.0024 17.3 0.0 0.054 12.8 0.0 2.0 2 0 0 2 2 2 2 Glucose / Sorbosone dehydrogenase Peptidase_S76 PF13611.6 CDF37282.1 - 0.077 13.3 0.0 0.091 13.1 0.0 1.1 1 0 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 Flavi_NS4A PF01350.17 CDF37284.1 - 0.1 12.6 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A HTH_Tnp_Tc3_1 PF11427.8 CDF37286.1 - 7.3e-09 35.3 0.0 1.5e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF37286.1 - 0.00031 20.4 0.9 0.00073 19.2 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF37286.1 - 0.00037 20.2 0.0 0.0012 18.5 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 CDF37286.1 - 0.0022 18.6 6.1 2.5 8.8 3.8 3.5 1 1 1 2 2 2 2 Homeodomain-like domain HTH_11 PF08279.12 CDF37286.1 - 0.008 16.1 0.1 0.11 12.5 0.0 2.5 2 1 1 3 3 3 1 HTH domain Sigma70_r4_2 PF08281.12 CDF37286.1 - 0.068 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_9 PF08221.11 CDF37286.1 - 0.3 11.2 1.0 1.1 9.4 0.5 2.0 1 1 1 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Pribosyltran_N PF13793.6 CDF37287.1 - 0.15 12.0 0.2 0.32 10.9 0.2 1.5 1 0 0 1 1 1 0 N-terminal domain of ribose phosphate pyrophosphokinase TctB PF07331.11 CDF37287.1 - 0.6 10.4 5.4 13 6.0 0.2 2.8 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Pkinase PF00069.25 CDF37288.1 - 1.9e-26 93.0 0.1 3.1e-26 92.3 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37288.1 - 1.6e-10 40.7 1.5 1.4e-09 37.7 1.5 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF37288.1 - 3.5e-09 35.9 0.2 5.3e-09 35.3 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF37288.1 - 4.9e-05 22.8 0.0 0.019 14.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CDF37288.1 - 0.00019 21.5 0.0 0.00044 20.3 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF37288.1 - 0.015 14.7 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GTP_EFTU PF00009.27 CDF37289.1 - 4e-45 153.7 0.1 7.4e-45 152.9 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDF37289.1 - 2.9e-20 72.1 0.0 6.1e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF37289.1 - 3e-08 33.9 0.1 1.2e-07 32.1 0.3 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF37289.1 - 2.4e-06 27.6 0.0 4.9e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDF37289.1 - 0.027 14.5 0.0 0.061 13.4 0.0 1.6 1 0 0 1 1 1 0 Elongation Factor G, domain II DUF2633 PF11119.8 CDF37291.1 - 0.064 13.2 1.2 0.13 12.2 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) Tricorn_C1 PF14684.6 CDF37291.1 - 0.21 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease C1 domain Thioredoxin PF00085.20 CDF37297.1 - 2e-27 95.2 0.0 4.3e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin UBX PF00789.20 CDF37297.1 - 1.9e-13 50.4 0.0 4.2e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA PF00627.31 CDF37297.1 - 4.5e-06 26.4 0.9 6.5e-06 25.9 0.0 1.7 2 0 0 2 2 1 1 UBA/TS-N domain Thioredoxin_8 PF13905.6 CDF37297.1 - 2.2e-05 24.7 0.0 4.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CDF37297.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 Redoxin OST3_OST6 PF04756.13 CDF37297.1 - 0.002 17.6 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CDF37297.1 - 0.0046 17.4 0.6 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDF37297.1 - 0.0054 16.9 0.0 0.0054 16.9 0.0 2.2 2 0 0 2 2 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CDF37297.1 - 0.0091 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family MCM3AP_GANP PF16769.5 CDF37297.1 - 0.0095 14.3 5.7 0.014 13.7 5.7 1.2 1 0 0 1 1 1 1 MCM3AP domain of GANP DIM1 PF02966.16 CDF37297.1 - 0.019 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 TraF PF13728.6 CDF37297.1 - 0.53 10.1 0.0 0.53 10.1 0.0 3.0 3 1 1 4 4 3 0 F plasmid transfer operon protein Protocadherin PF08374.11 CDF37297.1 - 2.2 8.2 6.6 7.3 6.5 6.7 1.8 2 0 0 2 2 2 0 Protocadherin Methyltransf_3 PF01596.17 CDF37300.1 - 6.1e-41 139.9 0.1 9.1e-41 139.4 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase DHQ_synthase PF01761.20 CDF37300.1 - 4.2e-07 29.4 0.0 8.6e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase Methyltransf_31 PF13847.6 CDF37300.1 - 1e-06 28.6 0.1 1.6e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CDF37300.1 - 1.5e-06 29.1 0.0 3.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDF37300.1 - 5.5e-06 26.1 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDF37300.1 - 1.2e-05 25.9 0.0 3.7e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDF37300.1 - 0.00032 20.5 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CDF37300.1 - 0.001 18.7 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Spermine_synth PF01564.17 CDF37300.1 - 0.002 17.6 0.1 0.0033 16.9 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Catalase PF00199.19 CDF37302.1 - 2.4e-149 497.6 0.4 2.9e-149 497.4 0.4 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CDF37302.1 - 2.4e-17 62.9 0.1 4.3e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF2250 PF10007.9 CDF37302.1 - 0.13 12.4 0.0 0.31 11.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) IF2_assoc PF08364.11 CDF37305.1 - 4.5 7.6 8.9 7.1 7.0 0.3 3.6 3 1 0 3 3 3 0 Bacterial translation initiation factor IF-2 associated region Hemerythrin PF01814.23 CDF37306.1 - 0.00011 22.9 2.6 0.25 11.9 0.1 2.8 3 0 0 3 3 3 2 Hemerythrin HHE cation binding domain Cyclin_N PF00134.23 CDF37309.1 - 9e-43 145.1 3.8 2.3e-39 134.0 0.7 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDF37309.1 - 5.2e-23 81.4 0.2 7.7e-23 80.8 0.2 1.2 1 0 0 1 1 1 1 Cyclin, C-terminal domain SKN1 PF03935.15 CDF37309.1 - 0.16 10.3 0.0 0.23 9.8 0.0 1.1 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) Methyltransf_31 PF13847.6 CDF37312.1 - 1.2e-06 28.4 0.0 1.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CDF37312.1 - 2e-05 24.4 0.0 2.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 CDF37312.1 - 4.9e-05 22.9 0.0 7.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDF37312.1 - 8.9e-05 22.2 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 CMAS PF02353.20 CDF37312.1 - 0.0013 18.1 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 CDF37312.1 - 0.034 13.9 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 CDF37312.1 - 0.069 13.9 0.0 0.22 12.3 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Eco57I PF07669.11 CDF37312.1 - 0.22 12.0 0.0 0.44 11.1 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Phage_holin_2_4 PF16082.5 CDF37313.1 - 0.063 13.0 0.3 0.21 11.4 0.3 1.9 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Gln-synt_C PF00120.24 CDF37314.1 - 6.8e-18 64.8 0.0 2.5e-16 59.7 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CDF37314.1 - 2.9e-14 52.6 0.0 5.2e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain PRIMA1 PF16101.5 CDF37316.1 - 0.48 10.5 3.5 0.5 10.4 3.5 1.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Gln-synt_C PF00120.24 CDF37317.1 - 1.2e-16 60.7 0.0 1.9e-15 56.7 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CDF37317.1 - 3.5e-11 42.7 0.0 5.9e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain BIR PF00653.21 CDF37318.1 - 0.14 12.8 0.0 0.21 12.3 0.0 1.2 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain WRC PF08879.10 CDF37319.1 - 0.0064 16.2 1.0 0.0064 16.2 1.0 2.1 3 0 0 3 3 3 1 WRC Peptidase_C48 PF02902.19 CDF37324.1 - 2.9e-23 82.9 0.0 5.6e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Exo_endo_phos PF03372.23 CDF37325.1 - 5.7e-07 29.3 0.0 1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Plant_tran PF04827.14 CDF37326.1 - 1.4e-79 266.4 0.0 1.9e-79 266.1 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF37326.1 - 9.5e-13 48.1 0.0 1.9e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Sulfotransfer_3 PF13469.6 CDF37329.1 - 0.014 15.8 0.1 0.026 14.9 0.0 1.4 2 0 0 2 2 2 0 Sulfotransferase family Sulfotransfer_1 PF00685.27 CDF37329.1 - 0.026 14.0 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain UCH PF00443.29 CDF37332.1 - 2.7e-16 59.9 0.0 3.8e-12 46.3 0.0 2.9 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF1682 PF07946.14 CDF37333.1 - 1.2e-53 182.4 2.7 1.6e-53 182.0 2.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF599 PF04654.12 CDF37333.1 - 0.00039 19.9 1.1 0.00058 19.3 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF599 TPR_19 PF14559.6 CDF37334.1 - 2.1e-08 34.6 0.0 0.00055 20.4 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDF37334.1 - 6.5e-08 32.2 0.4 0.0018 18.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF37334.1 - 3.3e-07 29.9 0.6 0.0033 17.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF37334.1 - 1e-06 28.3 1.2 0.037 14.0 0.0 3.3 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDF37334.1 - 1.3e-06 28.4 3.0 0.087 13.5 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF37334.1 - 2.9e-06 27.6 2.2 0.17 12.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDF37334.1 - 3.7e-06 26.5 0.1 0.0036 17.0 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDF37334.1 - 5.1e-06 26.7 0.6 0.9 9.9 0.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37334.1 - 1.2e-05 25.3 0.1 0.71 10.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37334.1 - 2.4e-05 24.9 0.1 0.28 11.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF37334.1 - 0.00071 20.1 4.1 0.43 11.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDF37334.1 - 0.0016 18.3 2.1 0.69 9.9 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF37334.1 - 0.0049 16.9 0.0 0.02 15.0 0.0 2.1 2 0 0 2 2 1 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 CDF37334.1 - 0.0099 16.3 0.2 0.98 9.8 0.0 2.4 1 1 0 2 2 2 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 CDF37334.1 - 0.076 13.3 0.0 0.44 10.8 0.0 2.1 3 1 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDF37334.1 - 0.077 12.7 0.2 0.71 9.6 0.1 2.6 3 0 0 3 3 3 0 TPR repeat TPR_20 PF14561.6 CDF37334.1 - 0.091 13.1 0.0 1.5 9.2 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 CDF37334.1 - 0.15 12.1 0.1 2.8 8.0 0.0 2.3 2 0 0 2 2 2 0 Putative TPR-like repeat Glycos_transf_1 PF00534.20 CDF37336.1 - 4e-17 62.3 0.0 6.9e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF37336.1 - 4.9e-12 46.4 0.0 8.8e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDF37336.1 - 1.5e-06 28.8 1.1 1.5e-06 28.8 1.1 2.4 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CDF37336.1 - 2.3e-06 27.9 0.1 5e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDF37336.1 - 0.0027 17.7 0.3 0.0083 16.1 0.1 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 CARD PF00619.21 CDF37336.1 - 0.036 14.1 0.1 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Caspase recruitment domain CoA_trans PF01144.23 CDF37336.1 - 0.061 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase DnaJ PF00226.31 CDF37337.1 - 1.7e-22 79.3 0.3 1.7e-22 79.3 0.3 2.1 3 0 0 3 3 3 1 DnaJ domain CASP_C PF08172.12 CDF37337.1 - 0.044 13.1 13.3 0.084 12.2 13.3 1.4 1 0 0 1 1 1 0 CASP C terminal Snapin_Pallidin PF14712.6 CDF37337.1 - 0.2 12.1 6.8 7.6 7.0 2.2 2.6 2 0 0 2 2 2 0 Snapin/Pallidin Spc7 PF08317.11 CDF37337.1 - 0.21 10.4 11.5 0.32 9.8 11.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Plk4_PB2 PF18409.1 CDF37337.1 - 0.26 12.0 2.5 0.48 11.1 1.8 1.8 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 DUF4407 PF14362.6 CDF37337.1 - 0.29 10.4 9.1 0.47 9.8 9.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GCN5L1 PF06320.13 CDF37337.1 - 1.5 9.0 7.2 1.3 9.2 0.6 2.6 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF3450 PF11932.8 CDF37337.1 - 2.5 7.3 14.9 2.3 7.5 2.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) CCDC-167 PF15188.6 CDF37337.1 - 2.8 8.3 7.2 1.2 9.5 2.3 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 OmpH PF03938.14 CDF37337.1 - 3.7 7.9 10.6 6.6 7.1 10.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 CDF37337.1 - 3.9 6.6 10.5 1.1 8.4 6.3 1.8 1 1 1 2 2 2 0 TMPIT-like protein Exonuc_VII_L PF02601.15 CDF37337.1 - 5.7 6.4 10.6 1.2 8.7 7.4 1.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 CDF37337.1 - 6.1 7.4 6.2 4.1 7.9 1.6 2.5 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Pyr_redox_2 PF07992.14 CDF37338.1 - 1.1e-23 83.9 2.8 1.3e-14 54.1 0.2 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDF37338.1 - 9.9e-05 22.1 1.0 0.00031 20.5 0.0 2.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase Rubredoxin_C PF18267.1 CDF37338.1 - 0.00011 22.0 0.1 0.00028 20.7 0.1 1.7 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox PF00070.27 CDF37338.1 - 0.00012 22.6 0.4 0.71 10.5 0.1 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDF37338.1 - 0.00027 20.9 1.0 0.011 15.7 0.0 3.1 2 1 1 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CDF37338.1 - 0.0047 16.1 0.0 0.017 14.3 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CDF37338.1 - 0.013 14.8 0.1 0.49 9.6 0.0 3.2 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDF37338.1 - 0.014 15.6 0.0 0.072 13.3 0.0 2.3 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDF37338.1 - 4.5 6.2 7.9 14 4.6 2.8 2.9 3 0 0 3 3 3 0 FAD binding domain SHMT PF00464.19 CDF37339.1 - 5e-202 670.8 0.0 5.8e-202 670.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 CDF37339.1 - 0.031 13.6 0.0 0.081 12.2 0.0 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase XRN_N PF03159.18 CDF37340.1 - 2.1e-89 299.1 0.0 3e-89 298.6 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDF37340.1 - 3.4e-86 289.9 3.6 3.1e-60 204.4 1.3 2.2 1 1 1 2 2 2 2 Xrn1 helical domain Kelch_6 PF13964.6 CDF37341.1 - 1.1e-21 76.3 6.5 5.8e-05 23.2 0.1 5.6 3 1 2 5 5 5 4 Kelch motif Kelch_1 PF01344.25 CDF37341.1 - 2.3e-13 49.5 18.8 0.00017 21.1 0.1 6.0 5 3 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 CDF37341.1 - 7.3e-08 32.5 11.0 1.7e-05 24.9 0.1 5.3 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDF37341.1 - 3.8e-06 26.7 12.5 0.089 12.8 0.1 5.6 7 0 0 7 7 7 3 Kelch motif Kelch_4 PF13418.6 CDF37341.1 - 1.1e-05 25.4 20.7 0.026 14.5 0.1 6.4 6 2 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CDF37341.1 - 0.00032 20.6 10.8 0.028 14.4 0.1 4.8 6 0 0 6 6 6 2 Kelch motif C2 PF00168.30 CDF37342.1 - 1.7e-12 47.5 0.2 3e-12 46.7 0.1 1.4 1 1 0 1 1 1 1 C2 domain Lip_prot_lig_C PF10437.9 CDF37342.1 - 0.065 13.2 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus MIP PF00230.20 CDF37343.1 - 4.2e-26 92.1 23.3 1.3e-25 90.4 23.3 1.8 1 1 0 1 1 1 1 Major intrinsic protein CMAS PF02353.20 CDF37344.1 - 8.6e-40 136.7 0.6 1.1e-39 136.3 0.6 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 CDF37344.1 - 4.6e-17 62.2 0.0 7.6e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF37344.1 - 2.2e-14 53.9 0.0 1.1e-13 51.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF37344.1 - 5.1e-13 49.5 0.0 1.1e-12 48.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF37344.1 - 7.1e-13 48.7 0.0 1.1e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF37344.1 - 1.2e-11 45.2 0.0 2.6e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF37344.1 - 1.6e-08 34.3 0.0 2.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CDF37344.1 - 0.00012 21.6 0.0 0.00028 20.4 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 CDF37344.1 - 0.0018 18.4 0.0 0.0045 17.1 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 CDF37344.1 - 0.0034 17.2 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 CDF37344.1 - 0.0036 16.7 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 CDF37344.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase DREV PF05219.12 CDF37344.1 - 0.0079 15.3 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_32 PF13679.6 CDF37344.1 - 0.11 12.4 0.1 0.28 11.2 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain DUF938 PF06080.12 CDF37344.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.18 CDF37344.1 - 0.13 11.5 0.0 0.27 10.5 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain MafB19-deam PF14437.6 CDF37347.1 - 1.3e-25 89.8 0.0 1.5e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 CDF37347.1 - 1.5e-21 76.2 0.3 2.1e-21 75.7 0.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.6 CDF37347.1 - 0.0017 18.4 1.2 0.0048 17.0 1.2 1.7 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 CDF37347.1 - 0.036 14.2 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 CDF37347.1 - 0.051 13.5 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 APOBEC-like N-terminal domain DUF1487 PF07368.11 CDF37347.1 - 0.051 13.0 0.0 0.082 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) NAD1 PF18778.1 CDF37347.1 - 0.14 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Inv-AAD PF18785.1 CDF37347.1 - 0.15 12.0 0.5 0.35 10.7 0.5 1.6 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase APOBEC2 PF18772.1 CDF37347.1 - 0.18 11.9 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 S1 PF00575.23 CDF37351.1 - 1.7e-11 44.3 0.0 2.5e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain TOBE_2 PF08402.10 CDF37351.1 - 0.19 11.9 1.3 1.3 9.3 0.3 2.3 2 1 0 2 2 2 0 TOBE domain zf-C3HC4_3 PF13920.6 CDF37354.1 - 1e-10 41.3 3.7 1.5e-10 40.8 3.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF37354.1 - 6.3e-10 38.8 4.9 9.6e-10 38.2 4.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF37354.1 - 1.3e-08 34.7 4.8 2e-08 34.1 4.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDF37354.1 - 5e-08 32.6 7.9 7.8e-08 32.0 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF37354.1 - 1.1e-07 31.6 4.6 1.8e-07 30.9 4.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDF37354.1 - 1.2e-07 31.6 5.7 3.7e-07 30.0 5.9 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 CDF37354.1 - 3.8e-07 30.3 8.1 5.9e-07 29.7 8.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 CDF37354.1 - 4.3e-05 23.6 8.5 6.6e-05 23.0 8.5 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 CDF37354.1 - 0.00073 19.8 5.1 0.0012 19.1 5.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDF37354.1 - 0.0028 17.7 1.6 0.0045 17.0 1.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 CDF37354.1 - 0.017 15.1 4.1 0.027 14.4 4.1 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 CDF37354.1 - 0.24 11.5 6.7 0.16 12.1 4.9 1.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 OAS1_C PF10421.9 CDF37355.1 - 0.0017 17.9 0.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 2 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus NAD_Gly3P_dh_N PF01210.23 CDF37357.1 - 3.2e-48 163.7 0.0 4.5e-48 163.2 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 CDF37357.1 - 2.2e-42 144.7 0.1 4.7e-42 143.6 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Na_H_Exchanger PF00999.21 CDF37358.1 - 4.4e-64 216.7 52.6 5.6e-64 216.3 52.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CDF37358.1 - 1.6e-25 89.6 0.0 4.7e-25 88.1 0.0 1.9 1 0 0 1 1 1 1 TrkA-N domain Cullin PF00888.22 CDF37359.1 - 5.7e-181 603.3 0.2 6.8e-181 603.0 0.2 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CDF37359.1 - 8.2e-24 83.4 0.6 3.3e-23 81.5 0.6 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain DNA_pol_B_thumb PF14791.6 CDF37360.1 - 1.1e-19 70.4 0.0 2.5e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 CDF37360.1 - 8.3e-08 32.4 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 CDF37360.1 - 2.5e-06 27.8 0.0 1.8e-05 25.0 0.0 2.4 3 0 0 3 3 3 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 CDF37360.1 - 1.5e-05 24.7 0.0 0.00034 20.4 0.0 2.6 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda P3A PF08727.11 CDF37360.1 - 0.07 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Poliovirus 3A protein like DUF4456 PF14644.6 CDF37360.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) KASH_CCD PF14662.6 CDF37363.1 - 0.0076 16.1 8.1 0.014 15.3 8.1 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.12 CDF37363.1 - 0.048 13.7 11.1 0.12 12.5 11.1 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3486 PF11985.8 CDF37363.1 - 0.063 13.7 11.4 0.11 12.9 11.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) DUF4094 PF13334.6 CDF37363.1 - 0.098 13.1 4.6 0.041 14.3 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) COG2 PF06148.11 CDF37363.1 - 0.12 12.5 2.5 0.24 11.5 2.5 1.6 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 CDF37363.1 - 0.12 12.6 0.7 0.29 11.4 0.7 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4201 PF13870.6 CDF37363.1 - 0.22 11.2 7.0 0.1 12.3 3.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DivIC PF04977.15 CDF37363.1 - 0.71 9.7 7.6 1.2 9.0 0.7 3.1 1 1 2 3 3 3 0 Septum formation initiator Spc7 PF08317.11 CDF37363.1 - 1.1 8.1 10.4 1.9 7.3 10.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 CDF37363.1 - 2.2 7.3 13.1 3.8 6.5 13.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4140 PF13600.6 CDF37363.1 - 5 7.6 11.5 2.6 8.5 5.8 3.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) APG6_N PF17675.1 CDF37363.1 - 7.1 7.2 11.4 10 6.6 10.1 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Acetyltransf_1 PF00583.25 CDF37364.1 - 5.7e-12 45.9 0.1 7.9e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF37364.1 - 0.00051 20.4 0.0 0.00088 19.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDF37364.1 - 0.016 15.2 0.0 0.028 14.4 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDF37364.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Peptidase_C14 PF00656.22 CDF37365.1 - 1.8e-40 139.4 0.0 7.4e-40 137.5 0.0 1.8 1 1 0 1 1 1 1 Caspase domain Peptidase_C13 PF01650.18 CDF37365.1 - 0.034 13.6 1.3 0.85 9.1 0.2 2.5 2 1 0 2 2 2 0 Peptidase C13 family Aminotran_1_2 PF00155.21 CDF37369.1 - 1.4e-42 146.2 0.0 1.6e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CDF37369.1 - 0.00018 20.1 0.0 0.00028 19.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 CDF37369.1 - 0.062 12.0 0.0 0.13 11.0 0.0 1.5 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Sec1 PF00995.23 CDF37370.1 - 4.8e-100 336.5 0.0 5.9e-100 336.2 0.0 1.1 1 0 0 1 1 1 1 Sec1 family Ras PF00071.22 CDF37371.1 - 3.5e-12 46.2 0.0 6.4e-11 42.1 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CDF37371.1 - 2.1e-11 44.1 0.0 3.5e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDF37371.1 - 2.6e-08 33.9 0.0 4.5e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CDF37371.1 - 1e-06 28.3 0.0 1.7e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 CDF37371.1 - 0.0031 17.1 0.0 0.0061 16.1 0.0 1.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Septin PF00735.18 CDF37371.1 - 0.0052 16.1 0.0 0.016 14.5 0.0 1.7 2 0 0 2 2 2 1 Septin AAA PF00004.29 CDF37371.1 - 0.067 13.6 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CDF37371.1 - 0.079 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 CDF37371.1 - 0.081 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 CDF37371.1 - 0.094 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Dynamin family PduV-EutP PF10662.9 CDF37371.1 - 0.24 11.2 0.1 0.4 10.4 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 CDF37371.1 - 0.25 11.8 0.0 0.39 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arm PF00514.23 CDF37372.1 - 1.7e-17 62.8 10.3 2.3e-06 27.5 0.1 6.3 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 CDF37372.1 - 3.7e-12 46.1 0.8 1.8e-05 24.7 0.1 4.2 4 0 0 4 4 4 3 Spinocerebellar ataxia type 10 protein domain SufE PF02657.15 CDF37372.1 - 0.014 15.3 0.3 0.13 12.1 0.0 2.5 3 0 0 3 3 3 0 Fe-S metabolism associated domain RICTOR_N PF14664.6 CDF37372.1 - 0.014 14.4 1.3 12 4.8 0.1 3.5 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term Peptidase_C12 PF01088.21 CDF37373.1 - 1.5e-54 184.9 0.0 1.7e-54 184.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Carbam_trans_N PF02543.15 CDF37374.1 - 1.5e-07 31.4 0.1 2.6e-06 27.4 0.1 2.2 1 1 0 1 1 1 1 Carbamoyltransferase N-terminus Carbam_trans_C PF16861.5 CDF37375.1 - 4.5e-60 202.1 0.0 6.3e-60 201.6 0.0 1.2 1 0 0 1 1 1 1 Carbamoyltransferase C-terminus Carbam_trans_N PF02543.15 CDF37375.1 - 0.00093 19.0 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyltransferase N-terminus HTH_DeoR PF08220.12 CDF37375.1 - 0.078 12.7 0.2 0.2 11.4 0.2 1.7 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain AMP-binding PF00501.28 CDF37376.1 - 2.4e-45 154.9 0.0 3.2e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Planc_extracel PF07595.12 CDF37376.1 - 0.012 15.4 0.3 0.029 14.1 0.3 1.7 1 0 0 1 1 1 0 Planctomycete extracellular AMP-binding_C PF13193.6 CDF37376.1 - 0.027 15.4 0.0 0.057 14.4 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain zf-DNL PF05180.12 CDF37377.1 - 1e-20 73.4 0.3 1.3e-20 73.0 0.3 1.2 1 0 0 1 1 1 1 DNL zinc finger Transket_pyr PF02779.24 CDF37378.1 - 3.3e-64 215.9 0.0 5.5e-64 215.1 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CDF37378.1 - 3.4e-63 213.4 0.0 6e-63 212.6 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 CDF37378.1 - 7.2e-54 181.6 0.0 1.2e-53 180.9 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CDF37378.1 - 3.4e-16 58.5 0.0 6.3e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus DUF1992 PF09350.10 CDF37381.1 - 2.3e-12 46.9 0.1 5.6e-12 45.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) DUF3391 PF11871.8 CDF37381.1 - 0.09 13.3 0.9 0.16 12.5 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Pkinase PF00069.25 CDF37382.1 - 5.2e-77 258.8 0.0 6.3e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37382.1 - 1.4e-43 149.1 0.0 1.8e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF37382.1 - 4e-07 29.6 0.0 1.5e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDF37382.1 - 5.9e-07 28.6 0.0 1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase PH PF00169.29 CDF37382.1 - 0.00012 22.5 0.0 0.00025 21.5 0.0 1.6 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 CDF37382.1 - 0.052 13.7 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology PCI PF01399.27 CDF37383.1 - 1.7e-20 73.4 0.5 5.4e-20 71.9 0.5 1.9 1 0 0 1 1 1 1 PCI domain mRNA_stabil PF13929.6 CDF37383.1 - 0.0065 15.5 0.1 0.016 14.2 0.1 1.6 1 0 0 1 1 1 1 mRNA stabilisation TPR_7 PF13176.6 CDF37383.1 - 0.007 16.3 0.2 8.8 6.6 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat ELF PF03317.13 CDF37383.1 - 0.037 14.0 0.2 0.82 9.7 0.0 2.3 2 0 0 2 2 2 0 ELF protein Pkinase PF00069.25 CDF37384.1 - 1.4e-78 264.0 0.0 1.8e-78 263.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37384.1 - 6.4e-40 137.1 0.0 8.3e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF37384.1 - 2.6e-10 40.1 0.0 9.5e-10 38.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 CDF37384.1 - 0.00015 21.2 0.2 0.00031 20.2 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CDF37384.1 - 0.077 12.5 0.3 0.17 11.3 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.23 CDF37384.1 - 0.14 12.0 0.0 4.8 7.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF995 PF06191.12 CDF37385.1 - 0.045 13.5 3.3 0.051 13.2 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF995) TolA PF06519.11 CDF37385.1 - 0.15 12.2 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 TolA C-terminal Lipase_3 PF01764.25 CDF37386.1 - 7.8e-27 93.9 0.0 2.2e-26 92.4 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CDF37386.1 - 0.0014 19.3 0.1 0.0031 18.1 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF37386.1 - 0.032 13.5 0.0 0.068 12.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2039 PF10217.9 CDF37387.1 - 1.1e-23 83.4 6.9 1.4e-23 83.0 6.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zf-C3HC4_3 PF13920.6 CDF37387.1 - 0.013 15.4 4.4 0.59 10.0 2.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 CDF37388.1 - 1.4e-22 80.3 0.0 5.6e-12 45.6 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37388.1 - 3.2e-08 33.2 0.0 1.4e-06 27.8 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase 2H-phosphodiest PF08975.10 CDF37389.1 - 0.095 12.7 0.3 0.13 12.3 0.2 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1868) DUF1258 PF06869.12 CDF37393.1 - 0.0085 15.6 0.1 0.011 15.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1258) MBOAT PF03062.19 CDF37395.1 - 3.7e-32 112.1 26.5 4.6e-32 111.7 26.5 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 CDF37395.1 - 0.00017 21.8 5.8 0.00017 21.8 5.8 2.0 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family Sel1 PF08238.12 CDF37396.1 - 2.2e-19 69.4 17.7 0.00025 21.6 0.0 6.6 6 0 0 6 6 6 5 Sel1 repeat Pkinase PF00069.25 CDF37396.1 - 0.00021 20.8 0.0 0.00035 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37396.1 - 0.051 12.9 0.1 0.083 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF1641 PF07849.11 CDF37396.1 - 0.079 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Smac_DIABLO PF09057.10 CDF37397.1 - 0.093 12.1 2.6 0.21 10.9 2.6 1.5 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases UPF0242 PF06785.11 CDF37397.1 - 5.4 7.1 12.2 10 6.2 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Plant_tran PF04827.14 CDF37398.1 - 3.3e-66 222.8 0.0 4.3e-66 222.4 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF37398.1 - 4.4e-13 49.2 0.0 6.4e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Cecropin PF00272.19 CDF37399.1 - 0.14 11.9 0.2 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Cecropin family Anoctamin PF04547.12 CDF37402.1 - 3.1e-60 204.3 0.1 3.7e-60 204.0 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel MukE PF04288.13 CDF37403.1 - 0.063 12.2 0.2 0.064 12.2 0.2 1.0 1 0 0 1 1 1 0 MukE-like family Branch PF02485.21 CDF37404.1 - 3.4e-30 105.4 0.2 5.3e-30 104.7 0.2 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme DnaJ-X PF14308.6 CDF37406.1 - 1.6e-22 80.0 1.5 3.5e-21 75.6 0.2 2.2 2 0 0 2 2 2 2 X-domain of DnaJ-containing DnaJ PF00226.31 CDF37406.1 - 3.6e-22 78.3 2.3 6.5e-22 77.4 2.3 1.5 1 0 0 1 1 1 1 DnaJ domain PBECR5 PF18814.1 CDF37406.1 - 0.0093 15.9 0.8 0.035 14.0 0.2 2.1 2 0 0 2 2 2 1 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 LepA_C PF06421.12 CDF37406.1 - 0.053 13.7 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus Crisp PF08562.10 CDF37407.1 - 0.035 14.7 7.3 0.35 11.5 1.8 3.3 1 1 2 3 3 3 0 Crisp Sulfotransfer_2 PF03567.14 CDF37408.1 - 2.4e-06 27.7 0.4 9.4e-06 25.7 0.4 2.1 1 1 0 1 1 1 1 Sulfotransferase family IMS PF00817.20 CDF37409.1 - 6.7e-39 133.3 0.0 1.6e-38 132.1 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CDF37409.1 - 2e-11 44.6 0.0 7.5e-11 42.8 0.0 2.0 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDF37409.1 - 0.0003 20.9 0.0 0.0012 19.1 0.0 2.0 1 0 0 1 1 1 1 IMS family HHH motif REV1_C PF16727.5 CDF37409.1 - 0.0091 16.4 0.2 0.018 15.4 0.2 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain mCpol PF18182.1 CDF37409.1 - 0.23 11.8 0.3 0.57 10.5 0.0 1.7 2 0 0 2 2 2 0 minimal CRISPR polymerase domain TCR PF03638.15 CDF37411.1 - 8e-25 86.9 50.1 9.6e-13 48.2 19.9 2.5 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain Hist_deacetyl PF00850.19 CDF37413.1 - 4.1e-59 200.6 0.0 5.3e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Cullin PF00888.22 CDF37414.1 - 4.9e-41 141.1 0.6 1.8e-29 102.9 0.1 2.0 1 1 1 2 2 2 2 Cullin family LCAT PF02450.15 CDF37414.1 - 0.091 11.9 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase VCBS PF13517.6 CDF37415.1 - 6e-42 142.1 38.9 1.2e-10 41.8 5.4 7.0 6 1 1 7 7 7 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDF37415.1 - 2.1e-21 75.7 43.0 0.00014 22.0 2.5 7.5 7 0 0 7 7 7 7 FG-GAP repeat UnbV_ASPIC PF07593.12 CDF37415.1 - 6.3e-06 26.1 0.1 2.3e-05 24.3 0.1 2.0 2 0 0 2 2 2 1 ASPIC and UnbV DDE_3 PF13358.6 CDF37417.1 - 3.8e-19 68.9 0.0 5.4e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HD PF01966.22 CDF37418.1 - 2.8e-11 43.7 1.1 4.5e-11 43.0 1.1 1.3 1 0 0 1 1 1 1 HD domain UbiA PF01040.18 CDF37420.1 - 2.5e-46 158.0 24.9 3.8e-46 157.4 24.9 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family AzlC PF03591.14 CDF37420.1 - 0.0018 18.8 1.4 0.0018 18.8 1.4 2.5 2 1 0 2 2 2 1 AzlC protein DUF2106 PF09879.9 CDF37420.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) HPS6 PF15702.5 CDF37420.1 - 0.16 9.9 0.0 0.22 9.5 0.0 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 6 protein Brix PF04427.18 CDF37422.1 - 3.9e-36 125.0 0.0 5.3e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 Brix domain CPSF100_C PF13299.6 CDF37422.1 - 0.63 10.2 0.1 0.63 10.2 0.1 2.5 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal XRN_M PF17846.1 CDF37422.1 - 0.7 8.8 4.9 0.99 8.3 4.9 1.1 1 0 0 1 1 1 0 Xrn1 helical domain PDZ PF00595.24 CDF37425.1 - 7.9e-06 26.1 0.1 1.4e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Ribosom_S12_S23 PF00164.25 CDF37426.1 - 1.2e-49 166.6 0.2 1.5e-49 166.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Piwi PF02171.17 CDF37427.1 - 1.3e-83 280.7 0.0 1.9e-83 280.2 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 CDF37427.1 - 1.8e-17 63.4 0.0 4.2e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CDF37427.1 - 1.8e-12 46.8 0.1 5.2e-12 45.2 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 CDF37427.1 - 3.8e-12 47.0 0.0 8.7e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 CDF37427.1 - 2.4e-09 37.4 0.0 9e-09 35.6 0.0 2.1 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CDF37427.1 - 3.9e-05 23.8 0.1 0.00011 22.3 0.0 1.9 2 0 0 2 2 2 1 Mid domain of argonaute DUF1664 PF07889.12 CDF37428.1 - 0.015 15.3 1.5 0.015 15.3 1.5 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Filament PF00038.21 CDF37428.1 - 0.87 9.1 39.9 1 8.9 17.0 3.7 3 1 0 3 3 3 0 Intermediate filament protein DUF948 PF06103.11 CDF37428.1 - 4.1 7.7 4.8 5.8 7.2 0.2 3.1 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 CDF37428.1 - 8.1 5.7 40.5 2.6 7.4 4.9 3.3 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding PolC_DP2 PF03833.13 CDF37430.1 - 2 6.2 5.5 2 6.2 5.5 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Peptidase_C26 PF07722.13 CDF37431.1 - 0.097 12.4 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Peptidase C26 PIF1 PF05970.14 CDF37435.1 - 6e-93 311.9 0.0 9e-93 311.3 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF37435.1 - 1.5e-59 201.4 0.0 3.5e-59 200.2 0.0 1.7 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF37435.1 - 1.4e-05 24.9 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF37435.1 - 0.069 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus tRNA-synt_1e PF01406.19 CDF37436.1 - 1.2e-47 162.8 0.0 1.5e-47 162.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 CDF37436.1 - 0.086 11.7 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1e PF01406.19 CDF37437.1 - 2.1e-18 66.7 0.1 2.5e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Beta_propel PF09826.9 CDF37439.1 - 1.3e-125 420.2 0.0 1.4e-125 420.0 0.0 1.0 1 0 0 1 1 1 1 Beta propeller domain Gene66 PF02053.15 CDF37442.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Gene 66 (IR5) protein Actin PF00022.19 CDF37443.1 - 2.5e-136 454.5 0.0 1e-135 452.5 0.0 1.7 1 1 0 1 1 1 1 Actin IBN_N PF03810.19 CDF37444.1 - 7.8e-08 32.1 0.0 3.8e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CDF37444.1 - 7e-06 26.2 0.1 4.4e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 Exportin 1-like protein dsrm PF00035.26 CDF37445.1 - 8e-05 23.3 0.1 0.013 16.2 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif Dicer_dimer PF03368.14 CDF37445.1 - 0.01 16.0 0.0 0.034 14.3 0.0 1.8 1 0 0 1 1 1 0 Dicer dimerisation domain Ras PF00071.22 CDF37446.1 - 4.2e-58 195.5 0.1 5.2e-58 195.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF37446.1 - 3.2e-36 124.2 0.1 4.5e-36 123.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF37446.1 - 2.4e-14 53.2 0.0 3e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDF37446.1 - 2.3e-05 24.0 0.2 9.8e-05 22.0 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CDF37446.1 - 0.00013 21.4 0.0 0.00019 20.9 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDF37446.1 - 0.00024 20.5 0.1 0.00029 20.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDF37446.1 - 0.0019 18.3 0.0 0.003 17.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 CDF37446.1 - 0.0057 16.2 0.0 0.0091 15.5 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 CDF37446.1 - 0.0077 16.5 0.0 0.12 12.7 0.0 2.2 1 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDF37446.1 - 0.011 15.6 0.0 1.9 8.4 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase ATPase_2 PF01637.18 CDF37446.1 - 0.014 15.4 0.0 0.026 14.4 0.0 1.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CDF37446.1 - 0.028 14.8 0.0 0.038 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 CDF37446.1 - 0.029 13.8 0.0 0.075 12.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 CDF37446.1 - 0.037 13.7 0.1 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDF37446.1 - 0.14 11.9 0.1 0.22 11.3 0.1 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_L17 PF01196.19 CDF37447.1 - 2.7e-34 117.9 0.4 4.4e-34 117.3 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Herpes_US9 PF06072.11 CDF37447.1 - 0.16 11.9 0.1 0.49 10.3 0.0 1.9 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 Baculo_Y142 PF04913.12 CDF37448.1 - 0.044 12.5 0.0 0.044 12.5 0.0 1.0 1 0 0 1 1 1 0 Baculovirus Y142 protein ASF1_hist_chap PF04729.13 CDF37449.1 - 3.3e-61 205.7 0.1 3.8e-61 205.5 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone SRP40_C PF05022.12 CDF37451.1 - 5.2e-21 75.3 1.1 5.2e-21 75.3 1.1 3.2 3 0 0 3 3 3 1 SRP40, C-terminal domain AF-4 PF05110.13 CDF37451.1 - 9.1e-05 20.8 33.1 9.1e-05 20.8 33.1 4.1 2 1 2 4 4 4 2 AF-4 proto-oncoprotein Endonuclease_5 PF04493.14 CDF37452.1 - 1.4e-50 171.7 0.0 1.8e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.16 CDF37452.1 - 0.0049 16.3 0.0 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function DUF99 TACC_C PF05010.14 CDF37453.1 - 3.2e-12 46.7 47.1 7.2e-10 39.0 24.1 2.8 1 1 1 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PKcGMP_CC PF16808.5 CDF37453.1 - 0.11 12.3 3.9 0.092 12.6 0.6 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GAS PF13851.6 CDF37453.1 - 0.8 9.0 58.1 0.065 12.6 14.4 4.6 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Baculo_F PF12259.8 CDF37453.1 - 1.2 7.6 15.2 0.23 9.9 4.8 2.3 1 1 0 2 2 2 0 Baculovirus F protein APG6_N PF17675.1 CDF37453.1 - 6.3 7.3 66.7 0.046 14.3 8.8 5.2 2 1 2 4 4 4 0 Apg6 coiled-coil region LCIB_C_CA PF18599.1 CDF37453.1 - 8.9 5.5 8.2 2.2 7.5 0.5 2.5 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Diphthami_syn_2 PF01902.17 CDF37454.1 - 2.1e-31 109.1 0.0 5.8e-31 107.7 0.0 1.7 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 CDF37454.1 - 4.2e-14 52.6 0.0 1.3e-09 38.1 0.0 2.4 2 0 0 2 2 2 2 Endoribonuclease L-PSP HLH PF00010.26 CDF37456.1 - 3.9e-05 23.5 0.1 7.2e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GAF_2 PF13185.6 CDF37456.1 - 0.004 17.5 0.0 0.0066 16.8 0.0 1.3 1 0 0 1 1 1 1 GAF domain NPBW PF15180.6 CDF37456.1 - 0.052 13.4 0.1 7.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Neuropeptides B and W YqaJ PF09588.10 CDF37457.1 - 0.019 15.1 0.0 0.046 13.9 0.0 1.7 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain Zn_Tnp_IS1595 PF12760.7 CDF37459.1 - 0.0095 15.9 3.4 0.027 14.4 3.4 1.8 1 0 0 1 1 1 1 Transposase zinc-ribbon domain CNDH2_N PF06278.11 CDF37459.1 - 0.036 14.3 0.6 0.056 13.6 0.6 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal OrfB_Zn_ribbon PF07282.11 CDF37459.1 - 0.063 13.2 4.7 0.12 12.4 4.7 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Tnp_zf-ribbon_2 PF13842.6 CDF37459.1 - 0.23 12.3 6.8 0.51 11.2 6.8 1.7 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon zf-C4_ClpX PF06689.13 CDF37459.1 - 0.76 9.7 6.3 2.5 8.1 6.3 1.9 1 1 0 1 1 1 0 ClpX C4-type zinc finger Nudix_N_2 PF14803.6 CDF37459.1 - 0.79 9.7 5.6 2.7 8.0 5.6 2.0 1 1 0 1 1 1 0 Nudix N-terminal Ima1_N PF09779.9 CDF37459.1 - 0.94 10.3 7.5 0.33 11.8 4.9 1.6 2 0 0 2 2 2 0 Ima1 N-terminal domain DUF1990 PF09348.10 CDF37461.1 - 4.4e-28 98.3 3.0 6e-28 97.8 3.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1990) Thioredoxin PF00085.20 CDF37466.1 - 2.7e-56 187.9 0.0 3.7e-27 94.3 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 CDF37466.1 - 2.2e-19 70.2 2.0 5.7e-19 68.8 2.0 1.7 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 CDF37466.1 - 1.2e-12 47.8 0.0 9.6e-06 25.1 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CDF37466.1 - 3.3e-09 37.2 0.0 0.00075 19.9 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDF37466.1 - 5.8e-09 36.2 0.0 0.016 15.5 0.0 4.1 3 1 1 4 4 4 3 Thioredoxin-like Thioredoxin_7 PF13899.6 CDF37466.1 - 4.1e-07 30.1 0.0 0.055 13.7 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 CDF37466.1 - 3.7e-05 23.6 0.2 0.059 13.3 0.0 2.7 3 0 0 3 3 3 2 AhpC/TSA family TraF PF13728.6 CDF37466.1 - 0.00014 21.8 0.0 2.1 8.1 0.0 3.1 3 0 0 3 3 3 2 F plasmid transfer operon protein Redoxin PF08534.10 CDF37466.1 - 0.00051 19.8 0.1 0.14 11.8 0.0 2.7 3 0 0 3 3 3 1 Redoxin Baculo_LEF5 PF04838.12 CDF37466.1 - 0.064 13.3 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 Glutaredoxin PF00462.24 CDF37466.1 - 0.11 12.8 2.4 9 6.6 0.0 3.5 3 1 0 3 3 3 0 Glutaredoxin NHL PF01436.21 CDF37467.1 - 7.8e-28 95.1 0.1 9.9e-05 22.2 0.0 6.5 6 0 0 6 6 6 5 NHL repeat Thioredoxin_8 PF13905.6 CDF37467.1 - 3.7e-13 49.6 0.0 9e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like SGL PF08450.12 CDF37467.1 - 2.4e-09 37.2 0.1 0.0014 18.3 0.0 3.9 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region AhpC-TSA PF00578.21 CDF37467.1 - 4e-05 23.5 0.0 7.3e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF37467.1 - 0.00011 22.0 0.0 0.00047 19.9 0.0 2.0 2 0 0 2 2 2 1 Redoxin Thioredoxin PF00085.20 CDF37467.1 - 0.00035 20.5 0.0 0.035 14.1 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin Arylesterase PF01731.20 CDF37467.1 - 0.00035 20.7 0.0 0.51 10.6 0.0 4.0 4 0 0 4 4 4 1 Arylesterase Thioredoxin_2 PF13098.6 CDF37467.1 - 0.011 16.2 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Lactonase PF10282.9 CDF37467.1 - 0.02 14.1 0.1 2.9 7.1 0.0 2.9 3 1 0 3 3 3 0 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.6 CDF37467.1 - 0.041 14.4 7.6 41 4.8 0.1 5.5 5 1 0 5 5 5 0 PQQ-like domain Mito_carr PF00153.27 CDF37468.1 - 1e-08 35.0 6.0 2.4e-05 24.2 0.2 3.3 2 1 0 2 2 2 2 Mitochondrial carrier protein PGM_PMM_I PF02878.16 CDF37469.1 - 1.3e-30 105.9 0.0 1.9e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDF37469.1 - 1.7e-28 99.1 0.0 3.4e-28 98.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDF37469.1 - 6.1e-10 39.6 0.0 2e-09 38.0 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDF37469.1 - 5.2e-07 29.8 0.0 1.1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF1295 PF06966.12 CDF37470.1 - 8.7e-55 185.8 1.3 1.1e-54 185.5 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 CDF37470.1 - 0.0033 17.4 0.0 0.011 15.7 0.0 2.0 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 CDF37470.1 - 0.0039 17.6 0.0 0.011 16.2 0.0 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Meckelin PF09773.9 CDF37470.1 - 0.12 10.4 0.0 0.17 10.0 0.0 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) ABC2_membrane_3 PF12698.7 CDF37470.1 - 0.37 9.8 1.9 0.38 9.8 0.1 1.8 2 1 0 2 2 2 0 ABC-2 family transporter protein Nucleoporin_N PF08801.11 CDF37472.1 - 1.5e-51 175.6 0.1 2.1e-51 175.1 0.1 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 CDF37472.1 - 4.8e-11 42.1 0.0 8.6e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal TFIIS_C PF01096.18 CDF37474.1 - 2.7e-19 68.7 7.4 2.7e-19 68.7 7.4 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 CDF37474.1 - 0.037 13.7 1.8 0.049 13.3 0.2 1.9 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain GDC-P PF02347.16 CDF37475.1 - 3.6e-91 306.1 0.1 4e-91 306.0 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein WD40 PF00400.32 CDF37477.1 - 8.8e-48 159.3 35.7 8.6e-08 32.7 0.1 8.5 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF37477.1 - 5.4e-12 45.9 9.1 0.089 13.1 0.0 7.3 2 1 6 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF37477.1 - 7.7e-07 28.1 5.8 5.4 5.5 0.0 7.2 6 1 2 8 8 8 3 Nucleoporin Nup120/160 NB-ARC PF00931.22 CDF37477.1 - 1.4e-06 27.7 0.0 2.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Nucleoporin_N PF08801.11 CDF37477.1 - 0.0049 15.7 0.6 3.6 6.2 0.0 4.3 2 1 3 5 5 5 1 Nup133 N terminal like Ge1_WD40 PF16529.5 CDF37477.1 - 0.072 12.0 0.1 51 2.7 0.0 4.2 3 3 2 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF37477.1 - 0.078 13.5 14.4 7.7 7.1 0.1 6.7 3 3 5 8 8 8 0 PQQ-like domain Plant_tran PF04827.14 CDF37478.1 - 3.6e-85 284.7 0.0 5e-85 284.2 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF37478.1 - 6.5e-13 48.7 0.0 9.9e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1_2 PF13586.6 CDF37478.1 - 0.097 13.1 0.2 0.18 12.2 0.2 1.4 1 0 0 1 1 1 0 Transposase DDE domain EF-hand_1 PF00036.32 CDF37480.1 - 8.9e-41 134.4 11.2 1.9e-10 39.5 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDF37480.1 - 1.9e-33 114.7 2.7 2e-17 63.4 1.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDF37480.1 - 1.4e-30 102.6 10.0 7e-10 38.0 0.1 5.2 4 2 2 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 CDF37480.1 - 4.3e-30 103.3 9.4 1.1e-13 50.9 0.4 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 CDF37480.1 - 3.9e-27 92.5 11.1 3e-07 29.6 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CDF37480.1 - 2.7e-15 56.4 0.0 4.5e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDF37480.1 - 1.2e-09 38.1 0.4 0.0002 21.2 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDF37480.1 - 9.5e-09 35.6 0.0 0.00035 20.9 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CDF37480.1 - 1.5e-07 31.3 1.6 0.015 15.3 0.2 2.4 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 CDF37480.1 - 5.8e-05 23.9 0.0 0.0013 19.5 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 CDF37480.1 - 0.00053 20.1 4.0 0.097 12.9 0.1 2.8 1 1 1 2 2 2 1 Dockerin type I domain TerB PF05099.13 CDF37480.1 - 0.0038 17.2 0.2 0.32 10.9 0.1 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 CDF37480.1 - 0.0052 17.1 0.3 2.4 8.5 0.3 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb4 Caleosin PF05042.13 CDF37480.1 - 0.014 15.4 0.7 0.91 9.4 0.5 3.2 1 1 0 1 1 1 0 Caleosin related protein DUF327 PF03885.13 CDF37480.1 - 0.018 15.0 1.3 4 7.4 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF327) EF-hand_14 PF17959.1 CDF37480.1 - 0.027 14.8 0.2 2.5 8.5 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain DUF4497 PF14924.6 CDF37480.1 - 0.028 14.9 0.0 5.5 7.5 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4497) DUF1456 PF07308.13 CDF37480.1 - 0.047 14.0 0.2 0.26 11.7 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) EF-hand_10 PF14788.6 CDF37480.1 - 0.053 13.4 0.4 0.21 11.5 0.4 2.1 1 0 0 1 1 1 0 EF hand DUF5580 PF17743.1 CDF37480.1 - 0.078 11.5 0.0 0.081 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Staphylokinase PF02821.16 CDF37480.1 - 0.094 13.2 0.3 0.97 9.9 0.0 2.2 1 1 1 2 2 2 0 Staphylokinase/Streptokinase family VbhA PF18495.1 CDF37480.1 - 0.13 12.1 0.1 55 3.7 0.0 3.4 3 0 0 3 3 3 0 Antitoxin VbhA Phage_tail_S PF05069.13 CDF37480.1 - 0.15 11.9 0.3 1.4 8.7 0.1 2.1 1 1 1 2 2 2 0 Phage virion morphogenesis family GPHH PF16905.5 CDF37480.1 - 0.22 11.3 0.0 5.4 6.9 0.0 2.8 4 0 0 4 4 4 0 Voltage-dependent L-type calcium channel, IQ-associated Glycos_trans_3N PF02885.17 CDF37480.1 - 0.35 10.7 3.5 2.4 8.1 0.2 3.4 3 2 0 3 3 3 0 Glycosyl transferase family, helical bundle domain Skp1 PF01466.19 CDF37480.1 - 0.5 10.5 5.6 1.8 8.7 0.2 3.0 3 0 0 3 3 3 0 Skp1 family, dimerisation domain DUF986 PF06173.12 CDF37481.1 - 2.3 8.3 6.1 0.26 11.3 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF986) DUF986 PF06173.12 CDF37483.1 - 2.3 8.3 6.1 0.26 11.3 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF986) GIY-YIG PF01541.24 CDF37484.1 - 0.015 15.6 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 GIY-YIG catalytic domain YIF1 PF03878.15 CDF37486.1 - 5.9e-60 202.8 2.5 5.9e-60 202.8 2.5 1.9 2 0 0 2 2 2 1 YIF1 Presenilin PF01080.17 CDF37486.1 - 1.4 7.6 9.5 2.8 6.6 9.5 1.5 1 0 0 1 1 1 0 Presenilin XRCC4 PF06632.12 CDF37486.1 - 4.4 6.1 8.5 6.1 5.6 8.5 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 POM121 PF15229.6 CDF37486.1 - 9.2 5.8 19.8 12 5.5 18.8 1.6 1 1 0 1 1 1 0 POM121 family Exo_endo_phos PF03372.23 CDF37488.1 - 2.7e-07 30.3 0.0 1.9e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 CDF37488.1 - 4.2e-05 23.4 0.0 8.1e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain ASH PF15780.5 CDF37488.1 - 0.025 14.8 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TsaE PF02367.17 CDF37489.1 - 1.5e-27 96.1 0.0 2.1e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 CDF37489.1 - 0.055 12.7 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 CDF37489.1 - 0.1 12.8 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDF37489.1 - 0.17 12.1 0.0 5.5 7.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 CDF37491.1 - 4.8e-56 185.4 25.8 2.7e-08 34.3 0.0 8.7 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF37491.1 - 5.9e-17 61.8 2.1 0.045 14.0 0.1 6.0 3 3 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 CDF37491.1 - 1.8e-10 41.2 0.1 5.1e-10 39.7 0.1 1.7 2 0 0 2 2 2 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 CDF37491.1 - 6.9e-08 31.8 3.3 0.077 11.9 0.7 4.3 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDF37491.1 - 2.7e-06 26.4 6.8 0.01 14.5 0.1 4.8 5 1 1 6 6 6 2 Nucleoporin Nup120/160 ASH PF15780.5 CDF37491.1 - 0.16 12.2 0.1 0.64 10.3 0.0 2.1 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin WD40_like PF17005.5 CDF37491.1 - 0.2 10.9 0.0 17 4.6 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain HAT PF02184.16 CDF37492.1 - 1.4e-13 50.5 43.0 0.00011 22.1 0.3 11.4 11 0 0 11 11 11 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 CDF37492.1 - 2.1e-13 49.9 27.0 0.0086 16.8 0.3 10.1 5 4 5 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37492.1 - 4.6e-06 27.2 16.0 0.12 13.0 0.0 6.6 5 2 2 7 7 7 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF37492.1 - 1.1e-05 25.3 11.0 0.95 9.5 0.0 6.0 8 1 0 8 8 8 3 Mad3/BUB1 homology region 1 TPR_19 PF14559.6 CDF37492.1 - 2.6e-05 24.6 0.1 0.034 14.7 0.0 4.6 4 2 1 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CDF37492.1 - 0.061 12.4 0.0 0.061 12.4 0.0 3.8 3 1 1 4 4 4 0 NRDE-2, necessary for RNA interference Suf PF05843.14 CDF37492.1 - 0.068 13.1 0.2 0.068 13.1 0.2 5.1 4 1 1 5 5 5 0 Suppressor of forked protein (Suf) TPR_12 PF13424.6 CDF37492.1 - 2.1 8.7 5.5 19 5.7 0.3 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat PBS_linker_poly PF00427.21 CDF37494.1 - 1.1e-35 122.5 0.1 1.4e-35 122.1 0.1 1.1 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide DUF4214 PF13946.6 CDF37494.1 - 0.023 14.7 0.2 0.051 13.6 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4214) Met_gamma_lyase PF06838.11 CDF37494.1 - 0.17 10.3 0.1 0.26 9.8 0.1 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase HemY_N PF07219.13 CDF37495.1 - 0.022 15.0 0.1 0.22 11.7 0.0 2.2 2 1 0 2 2 2 0 HemY protein N-terminus DUF3979 PF13141.6 CDF37497.1 - 0.14 12.4 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3979) rve PF00665.26 CDF37501.1 - 6.2e-20 71.6 0.1 9.7e-20 70.9 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF37501.1 - 2.1e-05 24.2 0.0 5e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Flavin_Reduct PF01613.18 CDF37502.1 - 3.3e-08 33.7 5.5 1.6e-07 31.5 3.2 2.7 2 1 0 2 2 2 1 Flavin reductase like domain NB-ARC PF00931.22 CDF37505.1 - 1.3e-20 73.7 0.1 2.5e-20 72.7 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain TIR_2 PF13676.6 CDF37505.1 - 4.3e-15 56.4 0.0 1.6e-14 54.5 0.0 2.0 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF37505.1 - 3.1e-13 49.8 13.8 0.66 10.3 0.2 10.6 8 3 4 12 12 12 5 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.20 CDF37505.1 - 1.1e-07 31.8 0.0 3.4e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 TIR domain PQQ_2 PF13360.6 CDF37505.1 - 1.4e-07 31.4 2.8 1.4e-07 31.4 2.8 3.8 1 1 2 3 3 3 1 PQQ-like domain WD40 PF00400.32 CDF37505.1 - 5.2e-07 30.3 23.6 0.17 12.8 0.0 9.9 11 0 0 11 11 11 3 WD domain, G-beta repeat PD40 PF07676.12 CDF37505.1 - 0.014 15.4 10.6 35 4.5 0.0 7.2 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat APAF1_C PF17908.1 CDF37505.1 - 0.019 14.9 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain PQQ PF01011.21 CDF37505.1 - 0.094 12.7 10.8 0.63 10.1 0.1 5.2 6 0 0 6 6 6 0 PQQ enzyme repeat PIF1 PF05970.14 CDF37506.1 - 7.3e-84 282.0 0.0 1.3e-50 172.6 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CDF37506.1 - 1.3e-12 47.9 0.0 2.2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDF37506.1 - 0.0082 16.0 0.1 1.7 8.4 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CDF37506.1 - 0.02 15.2 0.0 0.049 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain DDE_Tnp_1_3 PF13612.6 CDF37506.1 - 0.21 11.6 0.1 0.79 9.7 0.0 1.9 2 0 0 2 2 2 0 Transposase DDE domain MOLO1 PF17175.4 CDF37507.1 - 1.3e-15 57.6 0.0 2.3e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 CDF37507.1 - 1.4e-09 38.2 0.0 5.5e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 TPM domain zf-RING_2 PF13639.6 CDF37507.1 - 4.6e-05 23.7 1.6 4.6e-05 23.7 1.6 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CDF37507.1 - 0.00049 20.0 3.0 0.0024 17.8 3.0 2.1 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF37507.1 - 0.0017 18.1 5.6 0.074 12.9 1.4 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CDF37507.1 - 0.014 15.1 0.2 0.014 15.1 0.2 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 CDF37507.1 - 0.07 13.4 0.4 0.07 13.4 0.4 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain CCG PF02754.16 CDF37507.1 - 0.071 13.3 0.1 0.31 11.3 0.0 2.0 2 0 0 2 2 2 0 Cysteine-rich domain Mo-nitro_C PF06967.11 CDF37507.1 - 0.074 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus Zn_ribbon_17 PF17120.5 CDF37507.1 - 0.12 12.0 0.3 0.27 10.9 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CDF37507.1 - 0.16 12.1 6.3 0.18 11.9 2.4 2.5 2 1 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 CDF37507.1 - 0.31 11.0 3.8 0.96 9.4 3.8 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF37507.1 - 0.9 9.4 8.4 0.84 9.5 5.0 2.5 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDF37507.1 - 6.7 7.0 8.9 72 3.7 0.0 3.6 3 1 0 3 3 3 0 FANCL C-terminal domain Mito_carr PF00153.27 CDF37509.1 - 2.4e-34 117.1 1.7 1.4e-25 89.1 0.4 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Cpn60_TCP1 PF00118.24 CDF37510.1 - 3.8e-134 448.0 7.5 4.3e-71 240.0 0.8 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Sec23_trunk PF04811.15 CDF37511.1 - 8.4e-57 192.5 0.0 1.2e-56 192.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDF37511.1 - 1.8e-27 95.9 0.1 3.3e-27 95.1 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CDF37511.1 - 4.3e-25 87.5 0.3 8e-25 86.6 0.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDF37511.1 - 3.3e-14 52.6 9.4 7.6e-14 51.5 9.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CDF37511.1 - 1.4e-11 44.1 0.0 2.8e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat zinc_ribbon_10 PF10058.9 CDF37511.1 - 0.45 10.3 2.9 1.3 8.8 2.9 1.8 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein NolB PF17398.2 CDF37512.1 - 0.095 13.1 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 Nodulation protein NolB PHM7_ext PF12621.8 CDF37512.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Extracellular tail, of 10TM putative phosphate transporter Peptidase_M24 PF00557.24 CDF37513.1 - 1.9e-51 174.7 0.2 2.2e-51 174.5 0.2 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 RT_RNaseH_2 PF17919.1 CDF37514.1 - 2.2e-10 40.4 0.0 1.4e-09 37.9 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF37514.1 - 2.3e-08 33.8 0.5 0.00071 19.2 0.0 2.8 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CDF37514.1 - 1.5e-07 31.6 0.0 3.4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CDF37514.1 - 2.1e-05 24.3 0.0 5.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RT_RNaseH PF17917.1 CDF37514.1 - 0.00044 20.5 0.0 0.0032 17.7 0.0 2.5 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase GNT-I PF03071.15 CDF37515.1 - 5.2e-38 130.9 0.0 7.1e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 GNT-I family Glyco_tranf_2_3 PF13641.6 CDF37515.1 - 2.6e-05 24.2 1.4 5e-05 23.3 1.4 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 MGAT2 PF05060.14 CDF37515.1 - 0.00015 21.0 0.3 0.021 13.9 0.0 2.9 1 1 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) GTP_EFTU PF00009.27 CDF37518.1 - 2.2e-62 210.1 0.0 3.1e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDF37518.1 - 8.1e-28 96.6 0.0 1.9e-27 95.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CDF37518.1 - 9.4e-21 73.7 0.0 2.1e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CDF37518.1 - 5.8e-15 55.1 0.7 1.3e-14 54.0 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CDF37518.1 - 6.4e-15 55.3 0.3 1.7e-14 53.9 0.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF37518.1 - 0.005 16.9 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TPR_14 PF13428.6 CDF37519.1 - 9.5e-35 116.3 63.2 0.00015 22.3 4.3 12.7 4 3 9 13 13 13 11 Tetratricopeptide repeat TPR_19 PF14559.6 CDF37519.1 - 9.9e-27 93.3 18.2 1.9e-05 25.1 0.3 7.3 4 2 2 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37519.1 - 1e-19 70.9 62.7 8.9e-06 26.3 2.7 8.6 5 3 4 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 CDF37519.1 - 1.5e-19 68.4 27.0 0.03 14.4 0.3 11.7 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37519.1 - 1.9e-15 56.0 4.0 0.22 12.0 0.0 9.9 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDF37519.1 - 7.1e-13 48.4 30.6 4.9e-05 22.7 2.5 6.9 1 1 1 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDF37519.1 - 9.2e-11 41.1 2.2 5.4 7.5 0.1 8.8 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF37519.1 - 3.3e-10 40.1 31.2 6.9e-07 29.5 2.0 7.3 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDF37519.1 - 2.8e-07 30.1 2.6 1.1 9.2 0.1 6.7 9 0 0 9 9 8 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF37519.1 - 7.7e-07 29.1 9.1 0.43 10.6 0.0 6.8 6 2 1 7 7 7 2 Mad3/BUB1 homology region 1 TPR_11 PF13414.6 CDF37519.1 - 1.7e-06 27.6 11.4 0.026 14.2 0.1 6.0 7 1 0 7 7 7 2 TPR repeat TPR_6 PF13174.6 CDF37519.1 - 2.2e-06 27.9 26.8 15 6.4 0.3 11.0 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDF37519.1 - 2.9e-06 27.3 38.2 0.0039 17.3 3.3 6.2 3 2 2 6 6 6 3 Tetratricopeptide repeat MIT PF04212.18 CDF37519.1 - 4.5e-05 23.4 6.1 8.7 6.5 0.1 6.3 7 0 0 7 7 7 1 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 CDF37519.1 - 8.7e-05 22.3 22.0 5.3 7.3 0.1 8.7 10 0 0 10 10 10 1 Tetratricopeptide repeat SNAP PF14938.6 CDF37519.1 - 0.00018 21.0 6.5 0.3 10.5 0.2 4.3 4 1 0 4 4 4 2 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 CDF37519.1 - 0.00038 20.6 4.3 0.13 12.5 0.0 4.0 5 0 0 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 Suf PF05843.14 CDF37519.1 - 0.016 15.2 0.0 5.5 6.9 0.0 3.6 2 1 2 4 4 4 0 Suppressor of forked protein (Suf) DUF4075 PF13294.6 CDF37519.1 - 0.21 11.7 1.9 0.62 10.2 0.0 2.7 4 0 0 4 4 3 0 Domain of unknown function (DUF4075) TPR_5 PF12688.7 CDF37519.1 - 0.59 10.4 12.2 0.23 11.7 1.4 4.0 3 1 2 5 5 5 0 Tetratrico peptide repeat CoA_binding PF02629.19 CDF37522.1 - 2.8e-27 95.2 0.4 2.8e-27 95.2 0.4 2.4 2 1 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 CDF37522.1 - 2.5e-21 76.1 0.5 5.2e-21 75.1 0.5 1.5 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CDF37522.1 - 4e-11 42.9 0.1 8.2e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CDF37522.1 - 1.1e-05 25.9 0.5 3.6e-05 24.2 0.1 2.1 2 0 0 2 2 2 1 CoA binding domain Pmp3 PF01679.17 CDF37522.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.6 1 1 0 1 1 1 0 Proteolipid membrane potential modulator PIF1 PF05970.14 CDF37523.1 - 2.8e-46 158.4 0.6 5.6e-45 154.1 0.6 2.6 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 CDF37523.1 - 6e-20 71.8 0.1 5.2e-15 55.7 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CDF37523.1 - 3.3e-10 40.5 0.4 1.3e-09 38.5 0.1 2.2 2 1 0 2 2 1 1 AAA domain Herpes_Helicase PF02689.14 CDF37523.1 - 1e-05 23.7 0.1 0.0049 14.9 0.0 2.4 2 0 0 2 2 2 2 Helicase AAA_5 PF07728.14 CDF37523.1 - 2.9e-05 24.1 0.6 0.00062 19.8 0.3 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DEAD PF00270.29 CDF37523.1 - 0.0012 18.6 0.1 0.85 9.4 0.1 3.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.6 CDF37523.1 - 0.0081 16.0 0.2 0.023 14.5 0.2 1.8 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain NTPase_1 PF03266.15 CDF37523.1 - 0.01 15.7 7.3 0.21 11.5 0.4 3.8 4 0 0 4 4 4 0 NTPase AAA_16 PF13191.6 CDF37523.1 - 0.015 15.7 0.5 0.015 15.7 0.5 2.6 1 1 1 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 CDF37523.1 - 0.027 13.5 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 CDF37523.1 - 0.028 14.0 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 CDF37523.1 - 0.037 13.8 19.1 0.062 13.1 0.0 4.4 3 1 1 4 4 3 0 AAA domain AAA_29 PF13555.6 CDF37523.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DAP3 PF10236.9 CDF37523.1 - 0.06 12.5 1.0 0.13 11.4 0.2 1.9 1 1 1 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 UvrD-helicase PF00580.21 CDF37523.1 - 0.069 12.6 0.2 0.069 12.6 0.2 2.4 1 1 1 2 2 1 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 CDF37523.1 - 0.099 13.1 0.1 0.099 13.1 0.1 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF37523.1 - 0.12 12.6 4.0 0.067 13.5 0.5 2.5 2 1 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 CDF37523.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MeaB PF03308.16 CDF37523.1 - 0.52 9.2 4.4 0.34 9.9 2.3 1.7 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4337 PF14235.6 CDF37523.1 - 0.85 9.7 3.5 0.27 11.3 0.3 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4337) FAA_hydrolase_N PF09298.11 CDF37524.1 - 0.51 10.6 2.6 0.83 9.9 0.1 2.4 2 1 0 2 2 2 0 Fumarylacetoacetase N-terminal WD40 PF00400.32 CDF37526.1 - 1.6e-28 98.4 12.8 1.9e-06 28.5 0.3 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 CDF37526.1 - 0.03 13.0 1.2 1.1 7.8 0.2 3.3 3 2 1 4 4 4 0 Nucleoporin Nup120/160 CC2-LZ PF16516.5 CDF37526.1 - 0.14 12.6 2.2 0.27 11.6 2.2 1.4 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Prominin PF05478.11 CDF37526.1 - 0.19 9.6 1.6 0.25 9.2 1.6 1.0 1 0 0 1 1 1 0 Prominin Spc7 PF08317.11 CDF37526.1 - 0.26 10.1 3.7 0.37 9.6 3.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 CDF37526.1 - 0.6 10.8 2.6 1.5 9.5 2.6 1.6 1 0 0 1 1 1 0 SlyX T3SSipB PF16535.5 CDF37527.1 - 0.14 12.6 0.3 3.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Type III cell invasion protein SipB DUF3629 PF12302.8 CDF37528.1 - 0.02 14.3 0.1 0.027 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3629) RVT_1 PF00078.27 CDF37529.1 - 9.5e-09 35.1 0.1 5.6e-07 29.3 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) bZIP_1 PF00170.21 CDF37530.1 - 1.1e-10 41.4 17.4 1.2e-10 41.3 8.9 2.4 2 0 0 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 CDF37530.1 - 2e-07 31.0 9.2 2e-07 31.0 9.2 2.3 1 1 1 2 2 2 1 Basic region leucine zipper Csm1_N PF18504.1 CDF37530.1 - 0.0041 17.4 2.0 0.0041 17.4 2.0 2.1 2 0 0 2 2 2 1 Csm1 N-terminal domain PV-1 PF06637.11 CDF37530.1 - 0.0057 15.5 6.3 0.014 14.2 6.3 1.6 1 0 0 1 1 1 1 PV-1 protein (PLVAP) TSC22 PF01166.18 CDF37530.1 - 0.86 10.0 6.5 1.2 9.5 0.2 2.9 1 1 2 3 3 3 0 TSC-22/dip/bun family FAM76 PF16046.5 CDF37530.1 - 4.2 6.6 8.1 11 5.3 8.1 1.5 1 1 0 1 1 1 0 FAM76 protein rve PF00665.26 CDF37532.1 - 1e-19 70.9 0.0 1.5e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF37532.1 - 3.6e-05 23.5 0.1 9.3e-05 22.1 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain Glutaredoxin PF00462.24 CDF37532.1 - 0.051 13.8 0.0 0.15 12.3 0.0 1.7 2 0 0 2 2 2 0 Glutaredoxin HSP70 PF00012.20 CDF37535.1 - 1.9e-78 264.2 14.7 1.9e-78 264.2 14.7 2.3 1 1 1 2 2 2 1 Hsp70 protein Spt20 PF12090.8 CDF37535.1 - 0.06 13.0 8.5 0.12 11.9 8.5 1.4 1 0 0 1 1 1 0 Spt20 family AAA_11 PF13086.6 CDF37535.1 - 0.72 9.6 10.5 2.2 8.0 10.5 1.8 1 0 0 1 1 1 0 AAA domain Zip PF02535.22 CDF37535.1 - 0.94 8.6 7.9 1.7 7.8 7.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2228 PF10228.9 CDF37535.1 - 1.5 8.5 9.6 1.6 8.4 7.2 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) Membralin PF09746.9 CDF37535.1 - 4.2 6.3 5.8 7.6 5.5 5.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein Mucin PF01456.17 CDF37536.1 - 0.0004 20.4 14.5 0.00069 19.6 14.5 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.12 CDF37536.1 - 0.24 9.4 4.8 0.27 9.1 4.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 CDF37536.1 - 1.2 7.2 8.4 1.5 6.8 8.4 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 CDF37536.1 - 1.5 8.8 15.3 2.5 8.1 15.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MGC-24 PF05283.11 CDF37536.1 - 2.2 8.7 9.4 4.4 7.8 9.4 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TIMP PF00965.17 CDF37538.1 - 6.3e-13 48.9 0.0 8.1e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Trypsin PF00089.26 CDF37540.1 - 5.9e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Trypsin HCO3_cotransp PF00955.21 CDF37543.1 - 3.4e-122 408.9 13.3 8.4e-70 236.0 1.7 2.0 1 1 1 2 2 2 2 HCO3- transporter family SARAF PF06682.12 CDF37546.1 - 2.7e-34 119.3 0.0 3.8e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis OS-D PF03392.13 CDF37547.1 - 0.045 13.9 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D Kinesin PF00225.23 CDF37548.1 - 5.8e-49 166.8 0.5 1.4e-48 165.5 0.5 1.7 1 0 0 1 1 1 1 Kinesin motor domain APG6_N PF17675.1 CDF37548.1 - 5.1e-06 27.0 19.9 0.092 13.3 4.0 3.4 3 0 0 3 3 3 3 Apg6 coiled-coil region Lectin_N PF03954.14 CDF37548.1 - 0.0034 17.1 3.2 0.0034 17.1 3.2 3.0 2 2 1 3 3 3 1 Hepatic lectin, N-terminal domain PDCD7 PF16021.5 CDF37548.1 - 0.29 10.2 25.3 0.85 8.7 21.8 2.3 2 0 0 2 2 2 0 Programmed cell death protein 7 DUF4618 PF15397.6 CDF37548.1 - 1.5 8.2 14.5 0.99 8.8 12.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) V_ATPase_I PF01496.19 CDF37548.1 - 1.5 6.6 12.4 2.8 5.8 12.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 CDF37548.1 - 2 8.5 29.6 0.63 10.1 0.2 3.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 CDF37548.1 - 2.2 8.3 27.3 4.4 7.3 7.8 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 CDF37548.1 - 2.5 5.5 24.3 0.16 9.5 19.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 CDF37548.1 - 3.1 7.0 25.4 6.5 6.0 0.2 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) GAS PF13851.6 CDF37548.1 - 4 6.8 24.3 16 4.7 0.1 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 CDF37548.1 - 5.7 7.4 23.1 12 6.3 19.0 2.5 2 1 0 2 2 2 0 Fez1 Bacillus_HBL PF05791.11 CDF37548.1 - 8.2 6.2 9.6 12 5.7 2.8 3.0 2 1 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) MPS2 PF17060.5 CDF37548.1 - 8.4 5.5 11.7 10 5.3 8.9 2.2 2 0 0 2 2 2 0 Monopolar spindle protein 2 Glycos_transf_2 PF00535.26 CDF37549.1 - 3.8e-07 30.1 0.1 8.7e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CDF37549.1 - 8.7e-06 25.4 0.0 0.0017 17.9 0.1 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDF37549.1 - 1.3e-05 24.8 0.3 3.4e-05 23.4 0.3 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase NodZ PF05830.11 CDF37549.1 - 0.00048 19.1 0.1 0.015 14.1 0.1 2.2 2 0 0 2 2 2 1 Nodulation protein Z (NodZ) XG_FTase PF03254.13 CDF37549.1 - 0.26 9.8 0.0 0.46 9.0 0.0 1.3 1 0 0 1 1 1 0 Xyloglucan fucosyltransferase Proteasome PF00227.26 CDF37550.1 - 1e-41 142.6 0.0 1.3e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF37550.1 - 2.4e-13 49.5 0.2 4.8e-13 48.5 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SUI1 PF01253.22 CDF37551.1 - 2.1e-25 89.0 1.9 2.6e-25 88.8 1.9 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 CDF37551.1 - 0.022 15.1 0.1 0.035 14.4 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) PrsW-protease PF13367.6 CDF37555.1 - 6.5e-12 45.3 10.4 6.5e-12 45.3 10.4 1.8 2 1 0 2 2 2 1 PrsW family intramembrane metalloprotease DUF1186 PF06685.11 CDF37555.1 - 0.16 11.3 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) DUF5362 PF17319.2 CDF37555.1 - 3.9 7.4 9.6 6.6 6.7 4.6 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5362) DNA_pol_B_palm PF14792.6 CDF37556.1 - 2.5e-23 82.5 0.0 4.7e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 CDF37556.1 - 6.4e-15 54.7 0.2 2.1e-14 53.1 0.0 1.9 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 CDF37556.1 - 1.3e-11 44.7 0.1 2.4e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 CDF37556.1 - 1.7e-05 25.3 0.3 0.025 15.2 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 CDF37556.1 - 0.032 14.5 0.1 0.08 13.2 0.1 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain Ran-binding PF05508.11 CDF37556.1 - 0.072 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 RanGTP-binding protein Cytochrom_C1 PF02167.15 CDF37558.1 - 3.1e-93 311.5 0.0 3.7e-93 311.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 CDF37558.1 - 0.00026 21.2 0.0 0.00057 20.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDF37558.1 - 0.0046 18.1 0.1 0.014 16.5 0.1 2.1 1 1 0 1 1 1 1 Cytochrome c TMF_TATA_bd PF12325.8 CDF37559.1 - 0.36 11.0 6.7 0.86 9.8 0.2 2.7 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.12 CDF37559.1 - 0.73 9.9 5.3 1.1 9.3 4.8 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 CDF37559.1 - 1.8 9.1 5.3 1.6 9.2 2.8 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region Prp19 PF08606.11 CDF37559.1 - 2.9 7.9 5.4 13 5.8 3.0 2.6 2 1 0 2 2 2 0 Prp19/Pso4-like DUF883 PF05957.13 CDF37559.1 - 4 8.1 12.4 1.6 9.4 6.8 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) ACT_6 PF13740.6 CDF37560.1 - 6.9e-19 67.6 0.1 1.7e-09 37.5 0.2 3.1 3 0 0 3 3 3 2 ACT domain ACT_4 PF13291.6 CDF37560.1 - 4.5e-13 49.6 0.0 2.5e-05 24.8 0.1 2.2 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CDF37560.1 - 2.2e-12 46.5 2.0 5.5e-08 32.4 0.1 3.0 2 2 0 2 2 2 2 ACT domain ACT_7 PF13840.6 CDF37560.1 - 0.00043 20.0 1.1 0.022 14.5 0.0 3.0 3 0 0 3 3 3 1 ACT domain IML1 PF12257.8 CDF37560.1 - 0.047 12.8 0.1 0.063 12.4 0.1 1.1 1 0 0 1 1 1 0 Vacuolar membrane-associated protein Iml1 cNMP_binding PF00027.29 CDF37561.1 - 1e-07 31.9 0.1 1.8e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DNMT1-RFD PF12047.8 CDF37561.1 - 0.079 13.0 0.1 0.19 11.8 0.1 1.6 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain TPR_MLP1_2 PF07926.12 CDF37562.1 - 0.007 16.4 9.5 0.007 16.4 9.5 4.1 1 1 3 4 4 4 1 TPR/MLP1/MLP2-like protein Alanine_zipper PF11839.8 CDF37562.1 - 0.33 11.3 4.4 1.3 9.4 4.4 2.1 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein LPP PF04728.13 CDF37562.1 - 0.79 10.2 5.2 12 6.4 0.6 3.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Carbpep_Y_N PF05388.11 CDF37562.1 - 2 9.0 6.8 0.18 12.3 1.0 2.2 2 1 1 3 3 3 0 Carboxypeptidase Y pro-peptide Med9 PF07544.13 CDF37562.1 - 7.9 6.7 8.5 1.2 9.3 2.1 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 GAS PF13851.6 CDF37562.1 - 9.6 5.5 29.3 0.048 13.0 3.9 2.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding SepZ PF06066.11 CDF37563.1 - 0.034 14.4 2.3 0.064 13.5 2.3 1.4 1 0 0 1 1 1 0 SepZ Herpes_capsid PF06112.11 CDF37563.1 - 9.7 6.2 14.0 17 5.4 14.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein WD40 PF00400.32 CDF37565.1 - 8.5e-09 35.9 2.2 2.4 9.2 1.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF37565.1 - 0.031 14.6 0.0 0.97 9.8 0.0 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ldh_1_N PF00056.23 CDF37566.1 - 8.3e-32 110.2 0.4 2.3e-31 108.8 0.1 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDF37566.1 - 3.8e-30 105.0 0.1 1e-29 103.6 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Aminotran_5 PF00266.19 CDF37567.1 - 2.9e-90 302.9 0.0 3.4e-90 302.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDF37567.1 - 6.6e-07 28.9 0.0 8e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CDF37567.1 - 0.005 15.4 0.0 0.0077 14.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 CDF37567.1 - 0.073 11.8 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain DUF525 PF04379.14 CDF37568.1 - 1.5e-11 44.3 0.0 2.7e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 ApaG domain UVR PF02151.19 CDF37568.1 - 0.00085 19.0 2.0 0.00085 19.0 2.0 2.0 2 0 0 2 2 2 1 UvrB/uvrC motif MoCF_biosynth PF00994.24 CDF37569.1 - 9.7e-33 112.8 0.0 1.1e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain C2 PF00168.30 CDF37571.1 - 2.7e-05 24.4 0.0 0.00048 20.4 0.0 2.3 2 0 0 2 2 2 1 C2 domain MutS_III PF05192.18 CDF37572.1 - 0.022 15.0 0.0 0.048 13.9 0.0 1.7 1 1 0 1 1 1 0 MutS domain III MutS_V PF00488.21 CDF37573.1 - 1.4e-20 74.1 0.0 5.1e-20 72.3 0.0 1.8 2 0 0 2 2 2 1 MutS domain V Smr PF01713.21 CDF37573.1 - 6e-14 52.2 1.0 1.9e-13 50.6 0.2 2.3 2 0 0 2 2 2 1 Smr domain DUF1640 PF07798.11 CDF37573.1 - 0.017 15.1 3.5 0.031 14.3 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) ARGLU PF15346.6 CDF37573.1 - 0.022 14.6 10.7 0.051 13.5 10.7 1.6 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 V_ATPase_I PF01496.19 CDF37573.1 - 0.5 8.2 2.7 0.6 8.0 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2203 PF09969.9 CDF37573.1 - 2.1 9.1 6.4 1.2 9.9 3.4 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF724 PF05266.14 CDF37573.1 - 3 7.7 6.6 7 6.4 6.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) XendoU PF09412.10 CDF37575.1 - 2.5e-50 171.2 0.0 3.3e-50 170.8 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease XendoU EndoU_bacteria PF14436.6 CDF37575.1 - 0.0058 17.0 0.1 0.033 14.5 0.1 2.1 2 0 0 2 2 2 1 Bacterial EndoU nuclease DUF3500 PF12006.8 CDF37575.1 - 0.034 13.7 0.0 0.17 11.3 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3500) Vps52 PF04129.12 CDF37577.1 - 2.3e-11 43.1 0.3 2.8e-11 42.9 0.3 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family DUF3741 PF12552.8 CDF37577.1 - 0.2 11.7 0.2 0.2 11.7 0.2 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3741) DNA_pol3_alpha PF07733.12 CDF37578.1 - 8.3e-95 317.3 0.0 1.9e-94 316.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain DNA_pol3_finger PF17657.1 CDF37578.1 - 2.1e-56 189.9 0.0 4.5e-56 188.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha subunit finger domain PHP PF02811.19 CDF37578.1 - 4.3e-39 134.5 0.0 1.4e-38 132.8 0.0 2.0 2 0 0 2 2 2 1 PHP domain HHH_6 PF14579.6 CDF37578.1 - 2.1e-23 82.4 0.0 7.4e-23 80.6 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif DNA_ligase_aden PF01653.18 CDF37579.1 - 3.4e-70 236.7 0.0 1.5e-40 139.3 0.0 3.2 2 1 1 3 3 3 3 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 CDF37579.1 - 8.3e-27 92.9 3.1 8.3e-27 92.9 3.1 1.9 2 0 0 2 2 2 1 NAD-dependent DNA ligase OB-fold domain HHH_2 PF12826.7 CDF37579.1 - 2.8e-13 49.7 1.6 2.1e-09 37.3 0.1 3.5 4 0 0 4 4 4 2 Helix-hairpin-helix motif BRCT PF00533.26 CDF37579.1 - 4.1e-13 49.5 0.0 8.2e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain HHH_5 PF14520.6 CDF37579.1 - 1.1e-10 41.9 4.5 4.6e-06 27.1 0.6 3.4 3 0 0 3 3 3 2 Helix-hairpin-helix domain PTCB-BRCT PF12738.7 CDF37579.1 - 3e-07 30.3 0.1 7.1e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain RNA_pol_A_CTD PF03118.15 CDF37579.1 - 0.0067 16.2 0.0 5.6 6.8 0.0 3.6 2 1 1 3 3 3 1 Bacterial RNA polymerase, alpha chain C terminal domain BRCT_2 PF16589.5 CDF37579.1 - 0.011 16.2 0.0 0.026 14.9 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain SapB_1 PF05184.15 CDF37579.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Saposin-like type B, region 1 PTPLA PF04387.14 CDF37580.1 - 7e-44 149.5 15.2 7e-44 149.5 15.2 1.4 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA YajC PF02699.15 CDF37580.1 - 3.8 7.4 6.7 2.7 7.9 1.8 2.4 2 0 0 2 2 2 0 Preprotein translocase subunit CN_hydrolase PF00795.22 CDF37581.1 - 5.1e-54 183.3 0.0 5.8e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-met PF12874.7 CDF37585.1 - 1.3e-11 44.5 2.2 6.4e-08 32.7 0.9 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDF37585.1 - 2e-09 37.7 0.8 0.0016 18.7 0.3 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CDF37585.1 - 2.4e-08 34.1 1.5 0.0048 17.1 0.3 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CDF37585.1 - 2.4e-05 24.8 2.0 0.23 12.4 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CDF37585.1 - 0.00045 20.5 3.9 0.036 14.5 1.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CDF37585.1 - 0.0015 18.5 1.6 1.5 8.9 0.0 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger AKAP95 PF04988.12 CDF37585.1 - 0.0094 16.2 5.3 2.3 8.4 0.2 3.2 2 1 1 3 3 3 2 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_9 PF16293.5 CDF37585.1 - 0.017 15.0 2.7 0.66 9.9 0.5 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 CDF37586.1 - 0.0036 17.7 0.5 0.0036 17.7 0.5 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF37586.1 - 0.032 15.1 0.5 0.032 15.1 0.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 CDF37586.1 - 0.32 11.3 2.7 4.5 7.7 0.6 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding AAA PF00004.29 CDF37587.1 - 4.4e-40 137.2 0.0 6.2e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDF37587.1 - 1.9e-05 24.7 0.5 0.00016 21.7 0.5 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDF37587.1 - 5.9e-05 22.9 0.0 0.00016 21.4 0.0 1.8 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 CDF37587.1 - 0.00021 21.2 0.0 0.00044 20.2 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.14 CDF37587.1 - 0.00053 20.1 0.0 0.00076 19.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDF37587.1 - 0.00084 19.6 0.5 0.0074 16.6 0.5 2.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 CDF37587.1 - 0.0013 18.0 0.2 0.0038 16.5 0.1 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 CDF37587.1 - 0.0023 18.4 1.8 0.015 15.7 1.3 2.4 1 1 1 2 2 2 1 AAA ATPase domain TniB PF05621.11 CDF37587.1 - 0.0042 16.5 0.1 1.2 8.6 0.0 2.8 1 1 1 3 3 3 1 Bacterial TniB protein ATPase PF06745.13 CDF37587.1 - 0.0066 15.8 0.5 2.9 7.2 0.1 2.3 1 1 1 2 2 2 2 KaiC Sigma54_activat PF00158.26 CDF37587.1 - 0.014 15.1 0.1 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 CDF37587.1 - 0.014 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CDF37587.1 - 0.018 15.6 0.0 0.028 15.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDF37587.1 - 0.043 14.0 0.2 0.094 12.9 0.2 1.8 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDF37587.1 - 0.055 12.8 0.2 0.13 11.7 0.2 1.5 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CDF37587.1 - 0.081 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CDF37587.1 - 0.11 12.9 0.4 0.44 11.0 0.0 2.0 2 1 0 2 2 2 0 AAA domain SKI PF01202.22 CDF37587.1 - 0.14 12.3 0.1 0.37 10.9 0.1 1.7 1 0 0 1 1 1 0 Shikimate kinase AAA_25 PF13481.6 CDF37587.1 - 0.19 11.3 1.7 2.4 7.7 0.2 2.6 1 1 2 3 3 3 0 AAA domain AAA_7 PF12775.7 CDF37587.1 - 0.2 11.1 0.1 0.72 9.3 0.0 1.9 3 0 0 3 3 2 0 P-loop containing dynein motor region AAA_21 PF13304.6 CDF37587.1 - 0.4 10.5 1.0 10 5.8 0.0 2.5 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3598 PF12204.8 CDF37588.1 - 0.011 15.2 0.0 0.15 11.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3598) rve_3 PF13683.6 CDF37588.1 - 0.024 14.4 0.0 0.068 13.0 0.0 1.7 2 0 0 2 2 2 0 Integrase core domain ANAPC4_WD40 PF12894.7 CDF37589.1 - 1.3e-05 25.4 1.1 0.00018 21.8 0.0 3.0 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF37589.1 - 0.023 15.6 5.6 0.26 12.2 0.0 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat His_Phos_1 PF00300.22 CDF37590.1 - 1.4e-22 80.3 0.0 1.7e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) HA2 PF04408.23 CDF37591.1 - 3.1e-16 59.6 0.2 1e-15 57.9 0.2 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDF37591.1 - 6.4e-12 45.7 0.0 1.4e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDF37591.1 - 3.5e-11 43.4 0.2 1.9e-10 41.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF37591.1 - 1.9e-06 27.8 0.3 5.4e-06 26.3 0.3 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDF37591.1 - 0.00018 21.9 0.2 0.00039 20.8 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF37591.1 - 0.0085 15.8 0.3 0.017 14.8 0.3 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDF37591.1 - 0.028 13.5 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 CDF37591.1 - 0.039 13.9 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CDF37591.1 - 0.043 14.1 0.3 0.18 12.1 0.3 2.1 1 1 0 1 1 1 0 AAA domain MutL_C PF08676.11 CDF37592.1 - 3.1e-15 56.2 0.0 4.9e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 CDF37592.1 - 0.00075 19.3 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDF37592.1 - 0.0035 17.3 0.0 0.0086 16.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c PF02518.26 CDF37592.1 - 0.029 14.9 0.0 0.055 14.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-TFIIIC PF12660.7 CDF37593.1 - 0.0074 16.2 2.5 0.019 14.9 2.0 2.0 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex Proteasome PF00227.26 CDF37595.1 - 5.1e-29 101.1 0.2 6.3e-29 100.8 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit HEAT_2 PF13646.6 CDF37598.1 - 5.8e-16 58.7 2.5 3.5e-06 27.3 0.1 3.3 1 1 2 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 CDF37598.1 - 1.2e-07 31.7 1.0 0.22 12.3 0.1 4.5 4 0 0 4 4 4 3 PBS lyase HEAT-like repeat HEAT PF02985.22 CDF37598.1 - 9.8e-05 22.3 4.8 1.5 9.2 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 CDF37598.1 - 0.00013 22.4 0.9 0.55 10.8 0.1 3.4 3 0 0 3 3 3 2 HEAT-like repeat Cu-oxidase_3 PF07732.15 CDF37599.1 - 1e-32 112.6 0.1 2.2e-32 111.6 0.1 1.5 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 CDF37599.1 - 2.4e-27 96.0 0.0 1e-26 93.9 0.0 2.1 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CDF37599.1 - 9.8e-07 28.6 3.1 0.033 13.9 0.6 3.6 3 1 0 3 3 3 2 Multicopper oxidase DX PF01666.17 CDF37601.1 - 0.53 10.8 34.0 0.6 10.6 4.4 5.0 2 2 2 4 4 4 0 DX module DX PF01666.17 CDF37603.1 - 0.051 14.0 1.1 0.051 14.0 1.1 8.7 4 4 3 8 8 8 0 DX module CagY_I PF14585.6 CDF37603.1 - 0.46 10.6 1.7 27 4.9 0.1 3.2 3 0 0 3 3 3 0 CagY type 1 repeat LAMTOR5 PF16672.5 CDF37603.1 - 0.63 10.0 4.8 0.27 11.2 0.7 2.6 2 0 0 2 2 2 0 Ragulator complex protein LAMTOR5 RabGAP-TBC PF00566.18 CDF37604.1 - 7.3e-47 159.8 0.0 1.1e-46 159.2 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AC_N PF16214.5 CDF37604.1 - 0.0077 15.4 2.5 0.014 14.6 2.5 1.4 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region NOA36 PF06524.12 CDF37604.1 - 0.034 13.5 6.4 0.054 12.8 6.4 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 CDF37604.1 - 0.3 11.5 10.3 1.1 9.7 10.3 2.0 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 CDF37604.1 - 0.39 10.4 10.3 0.048 13.3 5.7 1.7 2 0 0 2 2 2 0 FAM176 family Cwf_Cwc_15 PF04889.12 CDF37604.1 - 0.42 10.3 12.6 0.028 14.2 6.8 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 CDF37604.1 - 0.72 9.9 7.8 0.081 12.9 3.3 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4611 PF15387.6 CDF37604.1 - 0.99 9.7 6.7 2.6 8.3 6.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RRN3 PF05327.11 CDF37604.1 - 1.3 7.5 4.3 2.7 6.4 4.3 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 CDF37604.1 - 2 7.5 15.7 0.093 11.9 9.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) SAP PF02037.27 CDF37605.1 - 4.4e-08 32.7 0.2 9.1e-08 31.7 0.2 1.6 1 0 0 1 1 1 1 SAP domain YjeF_N PF03853.15 CDF37607.1 - 4.8e-24 85.2 0.0 7.3e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus ECH_1 PF00378.20 CDF37612.1 - 5.5e-40 137.3 0.0 8.9e-40 136.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDF37612.1 - 1.1e-14 54.8 0.0 1.9e-14 53.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase FGE-sulfatase PF03781.16 CDF37614.1 - 3e-24 86.0 0.4 1.5e-21 77.1 0.4 3.0 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 CDF37614.1 - 7.4e-10 39.4 0.8 1.7e-09 38.3 0.8 1.6 1 0 0 1 1 1 1 DinB superfamily DUF1719 PF08224.11 CDF37614.1 - 0.38 9.8 0.9 7.3 5.6 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1719) RNase_J_C PF17770.1 CDF37615.1 - 0.017 16.2 0.0 0.018 16.1 0.0 1.1 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain ABC_tran PF00005.27 CDF37618.1 - 2.9e-46 157.4 11.7 9.2e-26 91.0 0.0 5.0 4 1 0 4 4 4 2 ABC transporter AAA_21 PF13304.6 CDF37618.1 - 1.9e-15 57.5 12.5 0.00028 20.8 0.1 5.1 4 1 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_CTD PF16326.5 CDF37618.1 - 7.1e-14 51.8 15.2 7.1e-14 51.8 15.2 4.5 4 0 0 4 4 4 1 ABC transporter C-terminal domain SMC_N PF02463.19 CDF37618.1 - 6.7e-10 38.8 5.7 0.00082 18.9 0.1 4.4 3 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF37618.1 - 2.1e-07 30.6 0.7 0.0028 17.4 0.1 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDF37618.1 - 1.4e-06 28.4 0.7 0.013 15.6 0.2 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase ABC_tran_Xtn PF12848.7 CDF37618.1 - 1.8e-06 27.9 5.6 1.8e-06 27.9 5.6 3.4 3 1 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 CDF37618.1 - 2.6e-05 24.2 5.4 0.0093 15.9 0.1 3.5 3 0 0 3 3 3 2 RsgA GTPase ATP-synt_ab PF00006.25 CDF37618.1 - 5.7e-05 22.9 0.1 0.031 13.9 0.0 2.7 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.6 CDF37618.1 - 0.00028 21.5 25.4 0.15 12.5 0.0 4.8 4 1 0 4 4 4 2 AAA domain AAA_18 PF13238.6 CDF37618.1 - 0.001 19.6 3.2 3.6 8.1 0.2 4.1 3 1 0 3 3 3 2 AAA domain AAA_22 PF13401.6 CDF37618.1 - 0.0011 19.3 5.9 6 7.1 0.0 4.8 4 1 0 4 4 3 0 AAA domain DLIC PF05783.11 CDF37618.1 - 0.0023 16.9 0.0 0.0058 15.5 0.0 1.6 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) AAA_28 PF13521.6 CDF37618.1 - 0.015 15.6 13.2 0.037 14.3 0.0 4.2 4 1 1 5 5 3 0 AAA domain NACHT PF05729.12 CDF37618.1 - 0.015 15.3 2.5 1.3 9.0 0.1 3.5 3 1 1 4 4 4 0 NACHT domain FtsK_SpoIIIE PF01580.18 CDF37618.1 - 0.019 14.4 6.5 0.45 9.8 0.1 3.4 2 1 1 3 3 3 0 FtsK/SpoIIIE family Roc PF08477.13 CDF37618.1 - 0.027 14.7 1.4 7 6.9 0.1 3.1 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 CDF37618.1 - 0.045 14.2 1.6 17 5.9 0.0 3.3 3 0 0 3 3 3 0 RNA helicase AAA_24 PF13479.6 CDF37618.1 - 0.045 13.5 7.8 1.6 8.4 0.0 4.0 5 0 0 5 5 4 0 AAA domain CLP1_P PF16575.5 CDF37618.1 - 0.067 13.0 0.1 6.1 6.6 0.0 2.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 CDF37618.1 - 0.14 12.5 2.7 12 6.3 0.0 4.2 2 2 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDF37618.1 - 0.17 11.3 0.0 6 6.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF4239 PF14023.6 CDF37618.1 - 0.24 11.1 0.9 0.73 9.5 0.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) FRP PF18032.1 CDF37618.1 - 0.26 11.9 3.6 0.3 11.7 0.1 2.6 2 0 0 2 2 2 0 Photoprotection regulator fluorescence recovery protein Cas_DxTHG PF09455.10 CDF37618.1 - 0.26 10.8 3.4 8.7 5.8 0.0 2.2 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family MeaB PF03308.16 CDF37618.1 - 0.46 9.4 9.0 1 8.3 0.2 3.6 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CDF37618.1 - 0.66 10.1 0.0 0.66 10.1 0.0 4.0 5 0 0 5 5 4 0 AAA domain AAA_16 PF13191.6 CDF37618.1 - 0.7 10.3 21.7 0.46 10.8 2.4 4.8 2 2 2 5 5 5 0 AAA ATPase domain AAA_15 PF13175.6 CDF37618.1 - 0.85 9.3 13.6 0.99 9.0 0.0 3.6 4 0 0 4 4 4 0 AAA ATPase domain Dynamin_N PF00350.23 CDF37618.1 - 1.1 9.3 15.1 1.7 8.7 0.3 4.3 4 1 0 4 4 4 0 Dynamin family AAA_11 PF13086.6 CDF37618.1 - 3.8 7.2 8.2 12 5.6 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDF37618.1 - 5 6.7 10.6 0.99 8.9 1.7 3.5 3 1 1 4 4 4 0 AAA domain VPS28 PF03997.12 CDF37619.1 - 4.2e-34 117.9 0.0 4.8e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 VPS28 protein CAP_N PF01213.19 CDF37619.1 - 0.44 10.0 1.4 0.85 9.0 1.4 1.5 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ubiquitin PF00240.23 CDF37620.1 - 2.9e-24 84.6 0.0 3.5e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDF37620.1 - 5.7e-11 42.1 0.0 6.2e-11 42.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDF37620.1 - 1.3e-05 25.6 0.1 5.6e-05 23.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDF37620.1 - 0.00023 21.0 0.0 0.00028 20.8 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF5628 PF18621.1 CDF37620.1 - 0.033 14.7 0.0 0.036 14.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5628) Raf1_HTH PF18579.1 CDF37620.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain OTU PF02338.19 CDF37621.1 - 9.8e-12 45.5 0.0 2.7e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease DUF1727 PF08353.10 CDF37621.1 - 0.21 11.5 0.1 0.49 10.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1727) UQ_con PF00179.26 CDF37622.1 - 3e-40 137.1 0.0 4.2e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CDF37622.1 - 0.0054 16.6 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 CDF37622.1 - 0.031 14.0 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 CDF37622.1 - 0.052 13.8 0.1 0.07 13.4 0.1 1.4 1 0 0 1 1 1 0 RWD domain Orn_Arg_deC_N PF02784.16 CDF37626.1 - 1.1e-58 198.5 0.0 1.3e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDF37626.1 - 1.5e-08 34.7 0.0 1.8e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain TIR_2 PF13676.6 CDF37627.1 - 7.8e-12 45.8 0.1 2e-11 44.6 0.0 1.7 2 0 0 2 2 2 1 TIR domain TIR PF01582.20 CDF37627.1 - 1.3e-08 34.8 0.1 4.4e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 TIR domain tRNA_anti-codon PF01336.25 CDF37627.1 - 0.002 18.1 0.0 0.0057 16.6 0.0 1.9 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain V_ATPase_I PF01496.19 CDF37631.1 - 1.8e-265 882.9 0.0 2e-265 882.8 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family WD40 PF00400.32 CDF37632.1 - 7.1e-37 124.8 17.0 3e-07 31.0 0.9 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 CDF37632.1 - 3.2e-35 121.2 0.0 4.8e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 CDF37632.1 - 1.3e-09 38.2 0.2 0.15 12.3 0.0 5.1 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CDF37632.1 - 0.0062 16.4 0.1 0.022 14.7 0.0 2.0 2 0 0 2 2 2 1 LisH WD40_like PF17005.5 CDF37632.1 - 0.21 10.9 0.0 8.3 5.6 0.0 3.1 3 1 2 5 5 5 0 WD40-like domain E1-E2_ATPase PF00122.20 CDF37633.1 - 2.3e-43 147.8 0.5 2.3e-43 147.8 0.5 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDF37633.1 - 5.5e-32 111.8 2.2 1.3e-31 110.6 2.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDF37633.1 - 6.8e-15 55.3 0.1 8.1e-11 42.2 0.0 3.0 3 0 0 3 3 3 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CDF37633.1 - 0.0018 18.1 1.1 0.02 14.6 1.0 2.5 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF37633.1 - 0.0067 16.8 0.6 0.017 15.5 0.6 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.15 CDF37633.1 - 0.079 13.3 0.6 30 5.1 0.0 3.2 3 0 0 3 3 3 0 BFD-like [2Fe-2S] binding domain CGI-121 PF08617.10 CDF37635.1 - 7.1e-32 110.8 0.0 8e-32 110.6 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 DUF2009 PF09418.10 CDF37636.1 - 1.5e-197 657.2 0.0 1.8e-197 657.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) LRR_RI_capping PF18779.1 CDF37637.1 - 0.0036 16.9 4.8 0.006 16.2 0.1 2.2 2 0 0 2 2 2 2 Capping Ribonuclease inhibitor Leucine Rich Repeat UPF0113_N PF17833.1 CDF37639.1 - 9.6e-32 109.4 0.0 1.4e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CDF37639.1 - 4.2e-23 81.4 0.0 6.4e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 CDF37639.1 - 0.043 13.8 0.0 0.061 13.3 0.0 1.2 1 0 0 1 1 1 0 PUA domain Rep_fac_C PF08542.11 CDF37640.1 - 4.1e-17 62.4 0.0 7.7e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CDF37640.1 - 1.7e-15 57.6 0.0 2.7e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDF37640.1 - 8.7e-12 45.1 0.1 7.8e-11 42.0 0.1 2.0 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CDF37640.1 - 7.4e-09 35.8 0.0 1.5e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 CDF37640.1 - 2.1e-06 27.8 0.0 3.3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF37640.1 - 4.5e-06 27.2 0.1 0.00095 19.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CDF37640.1 - 9.9e-06 25.1 0.0 0.00023 20.6 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 CDF37640.1 - 1.1e-05 25.2 0.0 1.8e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 CDF37640.1 - 2.2e-05 24.3 0.0 6.2e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDF37640.1 - 2.5e-05 24.3 0.0 4.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF37640.1 - 0.00021 21.6 0.2 0.084 13.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.6 CDF37640.1 - 0.002 18.0 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDF37640.1 - 0.0026 18.3 0.0 0.0052 17.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter TniB PF05621.11 CDF37640.1 - 0.0027 17.1 0.0 0.032 13.7 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein AAA_25 PF13481.6 CDF37640.1 - 0.0028 17.2 0.0 0.005 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF37640.1 - 0.0029 18.1 0.0 0.0047 17.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF37640.1 - 0.0043 17.4 0.5 0.0098 16.2 0.5 1.9 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CDF37640.1 - 0.0047 16.8 0.0 0.0091 15.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 CDF37640.1 - 0.015 15.1 0.2 6.7 6.4 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 CDF37640.1 - 0.016 15.6 0.0 0.046 14.1 0.0 1.9 1 1 0 1 1 1 0 RNA helicase GshA PF08886.11 CDF37640.1 - 0.017 13.7 0.0 0.028 13.0 0.0 1.2 1 0 0 1 1 1 0 Glutamate-cysteine ligase AAA_33 PF13671.6 CDF37640.1 - 0.018 15.2 0.2 0.031 14.4 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDF37640.1 - 0.028 14.7 0.0 0.054 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF37640.1 - 0.031 14.0 0.3 0.11 12.3 0.3 1.9 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 CDF37640.1 - 0.037 13.4 0.0 0.078 12.3 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.13 CDF37640.1 - 0.038 13.2 0.0 0.068 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 CDF37640.1 - 0.059 12.9 0.0 0.093 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDF37640.1 - 0.06 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 CDF37640.1 - 0.075 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.6 CDF37640.1 - 0.078 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CDF37640.1 - 0.092 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDF37640.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.8 2 0 0 2 2 1 0 RsgA GTPase UCH PF00443.29 CDF37641.1 - 6.5e-41 140.5 0.0 9.6e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF37641.1 - 4.2e-09 36.4 0.1 0.00021 21.0 0.0 3.4 2 2 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PRIMA1 PF16101.5 CDF37641.1 - 0.29 11.2 3.9 0.81 9.7 3.9 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SSB PF00436.25 CDF37642.1 - 4.7e-27 94.1 0.0 6.8e-27 93.5 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family RPT PF13446.6 CDF37644.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 A repeated domain in UCH-protein MPM1 PF17234.2 CDF37644.1 - 0.69 10.2 3.5 0.24 11.7 0.7 1.7 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 ABC_tran PF00005.27 CDF37645.1 - 3.7e-07 30.7 0.0 6.7e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF37645.1 - 4e-07 30.1 0.0 5.8e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF37645.1 - 0.0003 20.3 0.0 0.00036 20.0 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain CobA_CobO_BtuR PF02572.15 CDF37645.1 - 0.029 14.6 0.0 0.055 13.7 0.0 1.4 1 1 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP SbcCD_C PF13558.6 CDF37645.1 - 0.063 13.5 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit YbaB_DNA_bd PF02575.16 CDF37646.1 - 4.1e-17 62.2 5.7 5e-17 61.9 5.7 1.0 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family PE PF00934.20 CDF37646.1 - 0.021 15.1 0.9 0.08 13.3 0.9 1.9 1 1 0 1 1 1 0 PE family HGTP_anticodon PF03129.20 CDF37646.1 - 0.07 13.3 0.3 0.24 11.6 0.3 1.9 1 1 0 1 1 1 0 Anticodon binding domain DUF5600 PF18150.1 CDF37648.1 - 1.3e-32 112.6 0.1 2.7e-32 111.5 0.0 1.6 2 0 0 2 2 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 CDF37648.1 - 1.6e-16 60.1 0.0 4e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 CDF37648.1 - 1.9e-13 50.1 0.2 3.6e-13 49.1 0.2 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 CDF37648.1 - 1.5e-12 47.9 0.0 2.1e-11 44.2 0.0 2.2 1 1 0 1 1 1 1 Dynamin family FYVE PF01363.21 CDF37648.1 - 2.2e-10 40.5 14.8 3.3e-10 39.9 14.8 1.3 1 0 0 1 1 1 1 FYVE zinc finger MMR_HSR1 PF01926.23 CDF37648.1 - 2.4e-09 37.3 0.0 8.7e-09 35.5 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 CDF37648.1 - 8.8e-05 21.8 0.1 0.00024 20.4 0.1 1.8 1 0 0 1 1 1 1 EF hand FYVE_2 PF02318.16 CDF37648.1 - 0.00056 20.1 7.7 0.0011 19.1 7.7 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger EF-hand_7 PF13499.6 CDF37648.1 - 0.007 16.8 0.0 0.12 12.8 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDF37648.1 - 0.0086 15.9 0.1 0.024 14.5 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain Roc PF08477.13 CDF37648.1 - 0.032 14.4 0.0 2.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDF37648.1 - 0.19 11.3 0.0 16 5.1 0.0 2.2 2 0 0 2 2 2 0 Ras family zf-RING_2 PF13639.6 CDF37648.1 - 5.5 7.4 8.8 30 5.1 6.7 2.2 2 0 0 2 2 2 0 Ring finger domain ATP_bind_1 PF03029.17 CDF37649.1 - 1.2e-73 247.8 0.0 1.4e-73 247.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.23 CDF37649.1 - 0.0005 20.1 0.0 0.00082 19.4 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 CDF37649.1 - 0.0053 17.2 0.0 0.0085 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 CDF37649.1 - 0.0073 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 CDF37649.1 - 0.0095 16.1 0.0 0.019 15.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF37649.1 - 0.011 15.4 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDF37649.1 - 0.013 15.8 0.0 0.025 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDF37649.1 - 0.023 15.1 0.0 0.055 13.9 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 CDF37649.1 - 0.026 14.9 0.1 0.068 13.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 CDF37649.1 - 0.056 12.3 0.0 0.08 11.8 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain KTI12 PF08433.10 CDF37649.1 - 0.06 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 HECW1_helix PF18436.1 CDF37649.1 - 0.079 13.1 0.1 5.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 AAA_7 PF12775.7 CDF37649.1 - 0.1 12.1 0.1 0.36 10.3 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 CDF37649.1 - 0.12 12.9 0.8 0.37 11.3 0.3 2.3 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDF37649.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDF37649.1 - 0.16 12.3 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CDF37649.1 - 0.26 10.2 0.0 0.53 9.2 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Complex1_51K PF01512.17 CDF37651.1 - 1.4e-46 158.1 0.0 2.1e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CDF37651.1 - 1.2e-29 102.1 0.0 2.2e-29 101.4 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CDF37651.1 - 7.8e-08 32.1 0.0 1.7e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 SLBB domain GHMP_kinases_C PF08544.13 CDF37651.1 - 0.061 13.7 0.2 17 5.9 0.0 2.7 2 0 0 2 2 2 0 GHMP kinases C terminal FtsJ PF01728.19 CDF37652.1 - 9.3e-68 227.8 0.0 1.1e-67 227.5 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 CDF37652.1 - 0.012 15.2 0.0 0.032 13.9 0.0 1.6 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Ubie_methyltran PF01209.18 CDF37652.1 - 0.019 14.3 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CDF37652.1 - 0.025 15.3 0.0 0.069 13.9 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 CDF37652.1 - 0.074 14.1 0.0 0.22 12.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Prp18 PF02840.15 CDF37653.1 - 1.2e-46 158.3 0.2 1.2e-46 158.3 0.2 2.0 3 0 0 3 3 3 1 Prp18 domain PRP4 PF08799.11 CDF37653.1 - 6.8e-13 47.9 3.1 7.9e-13 47.7 0.2 2.6 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like DIM1 PF02966.16 CDF37661.1 - 0.08 12.7 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 Mitosis protein DIM1 Peptidase_C12 PF01088.21 CDF37662.1 - 1.5e-16 60.8 0.0 3.5e-16 59.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 CDF37662.1 - 0.00095 19.0 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases XFP PF03894.15 CDF37662.1 - 0.06 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Involucrin_N PF10583.9 CDF37663.1 - 0.0072 16.9 0.3 0.0084 16.7 0.3 1.1 1 0 0 1 1 1 1 Involucrin of squamous epithelia N-terminus Pkinase PF00069.25 CDF37664.1 - 2.3e-23 82.9 0.0 3.4e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37664.1 - 1.4e-12 47.5 0.0 1.9e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF37664.1 - 2.6e-06 26.5 0.0 2.6e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase WD40 PF00400.32 CDF37667.1 - 8.3e-54 178.4 21.1 7.5e-07 29.8 0.1 8.5 8 0 0 8 8 8 8 WD domain, G-beta repeat TIR_2 PF13676.6 CDF37667.1 - 8.6e-17 61.8 0.0 6.4e-16 59.0 0.0 2.5 2 0 0 2 2 2 1 TIR domain NB-ARC PF00931.22 CDF37667.1 - 2.8e-15 56.2 0.0 5.4e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF37667.1 - 3.5e-14 52.9 9.7 0.009 16.3 0.1 6.7 1 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.20 CDF37667.1 - 1.5e-07 31.4 0.0 5.6e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 TIR domain Nup160 PF11715.8 CDF37667.1 - 2.8e-07 29.6 3.8 1 7.9 0.0 6.9 5 2 3 8 8 8 2 Nucleoporin Nup120/160 DUF1513 PF07433.11 CDF37667.1 - 2e-05 23.8 8.8 0.0014 17.8 0.7 3.7 1 1 2 3 3 3 1 Protein of unknown function (DUF1513) WD40_like PF17005.5 CDF37667.1 - 0.00035 20.0 0.0 3.3 6.9 0.0 4.4 3 2 1 5 5 5 1 WD40-like domain Ge1_WD40 PF16529.5 CDF37667.1 - 0.016 14.2 1.6 40 3.0 0.0 4.7 2 1 3 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 CDF37667.1 - 0.017 15.4 0.0 0.063 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain WSC PF01822.19 CDF37667.1 - 0.031 14.5 0.1 0.08 13.1 0.1 1.6 1 0 0 1 1 1 0 WSC domain VID27 PF08553.10 CDF37667.1 - 0.053 12.6 0.2 3 6.8 0.0 2.8 1 1 1 3 3 3 0 VID27 C-terminal WD40-like domain PQQ_3 PF13570.6 CDF37667.1 - 0.056 13.9 17.2 10 6.7 0.1 7.3 1 1 7 8 8 8 0 PQQ-like domain Frtz PF11768.8 CDF37667.1 - 0.076 11.3 0.0 15 3.7 0.0 3.4 3 1 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz TIR-like PF10137.9 CDF37667.1 - 0.088 12.8 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain APAF1_C PF17908.1 CDF37667.1 - 0.18 11.8 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain Cytochrom_D1 PF02239.16 CDF37667.1 - 9.5 4.6 14.1 0.95 7.9 0.6 3.3 1 1 2 4 4 4 0 Cytochrome D1 heme domain PIF1 PF05970.14 CDF37673.1 - 1.4e-74 251.5 0.0 2.1e-59 201.5 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF37673.1 - 1.1e-59 201.8 0.0 2e-59 201.0 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF37673.1 - 5.5e-07 29.5 0.0 1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF37673.1 - 0.071 11.0 0.0 0.11 10.4 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF37673.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Sel1 PF08238.12 CDF37675.1 - 2.5e-06 28.0 0.2 0.054 14.2 0.0 3.4 3 0 0 3 3 3 2 Sel1 repeat VCBS PF13517.6 CDF37679.1 - 1.1e-26 93.2 15.3 8.2e-10 39.1 2.9 5.8 3 2 3 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDF37679.1 - 4.2e-10 39.6 19.8 0.0065 16.6 0.2 4.9 4 0 0 4 4 4 4 FG-GAP repeat UnbV_ASPIC PF07593.12 CDF37679.1 - 1.3e-08 34.7 0.3 2.4e-08 33.8 0.3 1.5 1 0 0 1 1 1 1 ASPIC and UnbV EF-hand_1 PF00036.32 CDF37679.1 - 7.4 6.4 12.2 8.5 6.2 0.1 4.3 5 0 0 5 5 5 0 EF hand Uma2 PF05685.12 CDF37686.1 - 1.2e-16 60.8 0.5 6.9e-15 55.0 0.5 2.2 1 1 0 1 1 1 1 Putative restriction endonuclease DUF1838 PF08894.11 CDF37688.1 - 8.9e-78 261.2 0.6 1.3e-77 260.7 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1838) Cyt-b5 PF00173.28 CDF37688.1 - 5.1e-07 29.8 0.0 1.2e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TIR_2 PF13676.6 CDF37690.1 - 6.4e-11 42.9 0.0 5.7e-10 39.8 0.0 2.8 2 0 0 2 2 2 1 TIR domain Roc PF08477.13 CDF37690.1 - 3e-09 37.1 0.1 1.2e-05 25.5 0.0 3.0 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 CDF37690.1 - 1.1e-06 28.7 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain TIR PF01582.20 CDF37690.1 - 4.1e-06 26.7 0.0 1.4e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 TIR domain Ras PF00071.22 CDF37690.1 - 0.0012 18.5 0.0 0.37 10.4 0.0 2.5 2 0 0 2 2 2 2 Ras family TPR_14 PF13428.6 CDF37690.1 - 0.0089 16.8 1.8 3.4 8.7 0.2 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat zinc_ribbon_6 PF14599.6 CDF37695.1 - 2.5e-20 72.2 2.3 2.5e-20 72.2 2.3 4.1 3 2 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 CDF37695.1 - 1.6e-16 60.5 20.3 1.6e-16 60.5 20.3 3.6 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 CDF37695.1 - 4.2e-06 27.0 9.3 4.2e-06 27.0 9.3 4.5 4 1 1 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDF37695.1 - 0.00022 21.0 9.4 0.00022 21.0 9.4 4.1 4 2 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF37695.1 - 0.0013 18.6 10.1 0.0013 18.6 10.1 5.3 3 2 1 4 4 4 1 zinc-RING finger domain Keratin_2_head PF16208.5 CDF37699.1 - 0.052 13.7 0.9 0.073 13.2 0.9 1.1 1 0 0 1 1 1 0 Keratin type II head Flavin_Reduct PF01613.18 CDF37700.1 - 4.6e-10 39.8 2.2 3.7e-09 36.8 2.2 2.1 1 1 0 1 1 1 1 Flavin reductase like domain ANAPC4_WD40 PF12894.7 CDF37702.1 - 1.9e-15 56.9 12.7 0.33 11.3 0.0 10.9 6 2 4 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF37702.1 - 1.1e-10 41.9 23.4 0.11 13.4 0.2 10.2 9 0 0 9 9 9 3 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF37702.1 - 1.2e-06 28.3 22.4 2.5e-05 24.0 2.0 4.2 3 1 1 4 4 4 3 PQQ-like domain NB-ARC PF00931.22 CDF37702.1 - 2.8e-05 23.4 0.0 6.5e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain PD40 PF07676.12 CDF37702.1 - 0.0064 16.4 10.3 53 3.9 0.0 7.6 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat APAF1_C PF17908.1 CDF37702.1 - 0.018 15.1 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain PQQ PF01011.21 CDF37702.1 - 0.018 15.0 11.3 0.45 10.5 0.1 5.7 5 0 0 5 5 5 0 PQQ enzyme repeat DPPIV_N PF00930.21 CDF37702.1 - 0.073 11.8 2.2 9.3 4.9 0.1 3.8 3 1 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF1513 PF07433.11 CDF37702.1 - 0.091 11.8 3.7 2.4 7.1 0.0 4.2 3 2 1 5 5 5 0 Protein of unknown function (DUF1513) eIF2A PF08662.11 CDF37702.1 - 0.1 12.5 3.0 0.62 9.9 0.0 3.7 4 1 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A Lactonase PF10282.9 CDF37702.1 - 0.18 11.0 0.0 28 3.8 0.0 3.8 3 2 0 3 3 3 0 Lactonase, 7-bladed beta-propeller TFIIIC_delta PF12657.7 CDF37702.1 - 0.53 10.2 2.4 36 4.2 0.1 3.9 4 0 0 4 4 4 0 Transcription factor IIIC subunit delta N-term Flavin_Reduct PF01613.18 CDF37703.1 - 1.1e-09 38.5 3.2 9.2e-09 35.5 3.2 2.1 1 1 0 1 1 1 1 Flavin reductase like domain Ntox10 PF15520.6 CDF37703.1 - 0.11 12.3 0.1 0.16 11.8 0.1 1.1 1 0 0 1 1 1 0 Novel toxin 10 PIF1 PF05970.14 CDF37706.1 - 2.6e-85 286.8 0.0 3.1e-49 168.1 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF37706.1 - 4.1e-53 180.4 0.1 8.1e-53 179.5 0.1 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF37706.1 - 1.6e-11 44.3 0.0 3e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF37706.1 - 0.0026 18.1 0.0 0.0085 16.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF37706.1 - 0.034 12.1 0.0 0.056 11.4 0.0 1.2 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF37706.1 - 0.061 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 CDF37706.1 - 0.25 11.1 0.2 9.4 5.9 0.0 2.6 2 1 0 2 2 2 0 AAA domain Retrotran_gag_2 PF14223.6 CDF37707.1 - 4.6e-33 113.8 0.0 8.6e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF37707.1 - 6.3e-20 71.6 0.1 2.1e-19 69.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF37707.1 - 3.8e-06 26.7 0.0 2.8e-05 23.9 0.0 2.4 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF37707.1 - 0.0034 17.1 0.0 0.009 15.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF37707.1 - 0.076 12.8 1.5 0.24 11.2 1.5 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF37707.1 - 0.27 11.4 4.0 0.59 10.3 4.0 1.6 1 0 0 1 1 1 0 Zinc knuckle Fer2 PF00111.27 CDF37708.1 - 5.7e-11 42.2 0.7 7.7e-11 41.8 0.7 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain YidD PF01809.18 CDF37710.1 - 9.4e-24 83.1 0.1 1.1e-23 82.9 0.1 1.0 1 0 0 1 1 1 1 Putative membrane protein insertion efficiency factor zf-C3HC4_2 PF13923.6 CDF37711.1 - 2.5e-06 27.2 3.1 6.9e-06 25.8 3.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF37711.1 - 0.0011 18.8 2.3 0.0035 17.2 2.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDF37711.1 - 0.0015 18.7 4.5 0.0039 17.3 4.5 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CDF37711.1 - 0.0015 18.3 4.6 0.0044 16.8 4.6 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 BRCT_3 PF18428.1 CDF37711.1 - 0.0018 18.3 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-RING_UBOX PF13445.6 CDF37711.1 - 0.0026 17.8 3.1 0.0066 16.5 3.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDF37711.1 - 0.0037 17.2 5.3 0.012 15.6 5.3 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CDF37711.1 - 0.053 13.9 5.8 0.17 12.3 5.8 1.9 1 0 0 1 1 1 0 Ring finger domain BRCT_2 PF16589.5 CDF37711.1 - 0.088 13.2 0.0 0.61 10.5 0.0 2.1 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain zf-RING_6 PF14835.6 CDF37711.1 - 0.2 11.6 8.3 0.16 11.8 4.8 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 CDF37711.1 - 1.5 9.0 5.3 2.8 8.1 5.3 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 AhpC-TSA PF00578.21 CDF37712.1 - 2.6e-29 101.6 0.0 3.3e-29 101.3 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF37712.1 - 1.6e-15 57.1 0.0 1.9e-15 56.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 CDF37712.1 - 0.0017 18.4 0.0 0.0024 18.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.12 CDF37712.1 - 0.0024 17.4 0.0 0.0028 17.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) ATG16 PF08614.11 CDF37713.1 - 0.0026 18.0 0.6 0.0026 18.0 0.6 1.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF4515 PF14988.6 CDF37713.1 - 0.0033 17.3 3.4 0.0044 16.9 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) APG6_N PF17675.1 CDF37713.1 - 0.0046 17.5 0.7 0.0071 16.9 0.7 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region HORMA PF02301.18 CDF37713.1 - 0.033 13.8 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 HORMA domain ZapB PF06005.12 CDF37713.1 - 0.13 12.8 8.0 0.23 11.9 8.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF334 PF03904.13 CDF37713.1 - 0.13 11.7 0.4 0.17 11.4 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) RRM_1 PF00076.22 CDF37714.1 - 0.021 14.6 0.1 0.036 13.9 0.1 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Clathrin PF00637.20 CDF37715.1 - 2.1e-141 465.3 1.1 8.2e-29 100.3 0.0 8.2 8 0 0 8 8 8 8 Region in Clathrin and VPS Clathrin_H_link PF13838.6 CDF37715.1 - 5e-17 61.6 0.0 3.7e-16 58.8 0.0 2.6 3 0 0 3 3 3 1 Clathrin-H-link Clathrin_propel PF01394.20 CDF37715.1 - 7.4e-13 48.1 0.0 0.021 15.1 0.0 4.7 4 0 0 4 4 4 4 Clathrin propeller repeat Clathrin-link PF09268.10 CDF37715.1 - 0.0071 15.7 0.0 0.017 14.5 0.0 1.7 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_8 PF13181.6 CDF37715.1 - 0.026 14.7 1.3 23 5.5 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF37715.1 - 0.038 14.8 8.8 80 4.5 0.0 7.5 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF37715.1 - 1.1 9.5 7.7 21 5.6 0.1 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF37715.1 - 2.1 8.3 9.8 55 3.8 0.1 5.8 6 1 0 6 6 6 0 Tetratricopeptide repeat PPR PF01535.20 CDF37715.1 - 7.5 7.0 6.9 39 4.8 0.0 5.1 6 0 0 6 6 6 0 PPR repeat Cpn60_TCP1 PF00118.24 CDF37717.1 - 1.4e-143 479.1 14.7 1.6e-143 478.9 14.7 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Membralin PF09746.9 CDF37718.1 - 2.7e-10 39.9 11.7 2.1e-06 27.0 0.0 3.0 3 0 0 3 3 3 3 Tumour-associated protein CLP1_P PF16575.5 CDF37720.1 - 1.2e-34 119.8 0.0 2.1e-34 119.0 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 CDF37720.1 - 2.1e-27 95.9 0.1 3.3e-27 95.2 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 CDF37720.1 - 2.2e-21 75.9 0.0 3.7e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor ATP_bind_1 PF03029.17 CDF37720.1 - 0.00067 19.5 0.2 0.0011 18.8 0.2 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 CDF37720.1 - 0.00067 19.7 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 CDF37720.1 - 0.0071 16.0 0.1 0.053 13.1 0.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CbiA PF01656.23 CDF37720.1 - 0.011 15.8 0.0 0.023 14.7 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRPRB PF09439.10 CDF37720.1 - 0.015 14.7 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.29 CDF37720.1 - 0.015 15.7 0.1 0.035 14.5 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF37720.1 - 0.043 14.2 0.0 0.073 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 CDF37720.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_31 PF13614.6 CDF37720.1 - 0.092 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF37720.1 - 0.094 13.2 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter SdpI PF13630.6 CDF37721.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 SdpI/YhfL protein family RRM_1 PF00076.22 CDF37723.1 - 2.3e-20 72.2 0.0 1.1e-06 28.4 0.0 4.9 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 CDF37723.1 - 0.00018 22.1 0.0 0.00047 20.7 0.0 1.7 2 0 0 2 2 2 1 Exonuclease bZIP_2 PF07716.15 CDF37724.1 - 4.7e-05 23.4 10.4 0.00011 22.2 10.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper DUF641 PF04859.12 CDF37724.1 - 0.0035 17.7 1.6 0.0063 16.9 1.6 1.4 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) bZIP_1 PF00170.21 CDF37724.1 - 0.0058 16.7 8.7 0.015 15.4 8.7 1.6 1 1 0 1 1 1 1 bZIP transcription factor UBA2_C PF16195.5 CDF37724.1 - 0.074 13.7 4.2 0.15 12.7 3.8 1.7 1 1 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus Csm1_N PF18504.1 CDF37724.1 - 0.15 12.5 1.9 0.29 11.5 1.9 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain Phlebovirus_NSM PF07246.11 CDF37724.1 - 0.18 11.1 1.5 0.27 10.6 1.5 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M PKcGMP_CC PF16808.5 CDF37724.1 - 0.42 10.5 2.1 0.73 9.7 2.1 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase WDCP PF15390.6 CDF37724.1 - 1.7 6.9 3.7 2.4 6.5 3.7 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Pkinase PF00069.25 CDF37725.1 - 5.2e-24 85.0 0.0 7.1e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37725.1 - 6.4e-15 55.1 0.0 8.9e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF37725.1 - 2.1e-09 36.7 0.3 3.4e-09 36.0 0.1 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CDF37725.1 - 0.00015 21.7 0.0 0.00038 20.5 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF37725.1 - 0.027 13.8 0.1 0.04 13.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 CDF37725.1 - 0.044 12.8 0.1 0.066 12.2 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Haspin_kinase PF12330.8 CDF37725.1 - 0.084 11.8 0.0 0.73 8.7 0.0 2.0 1 1 0 1 1 1 0 Haspin like kinase domain Med26 PF08711.11 CDF37726.1 - 5.5e-05 23.1 0.8 0.00013 21.9 0.0 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Thioredoxin PF00085.20 CDF37727.1 - 5.9e-23 80.8 0.2 9.6e-12 44.8 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 CDF37727.1 - 1e-05 25.9 0.1 3.8e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDF37727.1 - 2.8e-05 24.4 0.0 0.0029 17.9 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 CDF37727.1 - 0.02 14.2 0.1 0.046 13.1 0.1 1.7 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family Redoxin PF08534.10 CDF37727.1 - 0.021 14.5 0.1 0.1 12.3 0.1 1.9 1 1 0 1 1 1 0 Redoxin AhpC-TSA PF00578.21 CDF37727.1 - 0.068 13.1 0.0 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 AhpC/TSA family Thioredoxin_7 PF13899.6 CDF37727.1 - 0.08 13.1 0.1 2 8.7 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like Put_Phosphatase PF06888.12 CDF37728.1 - 1.5e-45 155.5 0.0 1.6e-45 155.3 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 CDF37728.1 - 2.5e-05 24.8 0.1 5.5e-05 23.6 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NuA4 PF09340.10 CDF37731.1 - 2.1e-16 59.6 0.0 2.9e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 SID-1_RNA_chan PF13965.6 CDF37734.1 - 2.7 6.3 14.6 5.7 5.2 14.6 1.5 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 KIX_2 PF16987.5 CDF37735.1 - 0.039 13.9 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 KIX domain NifU PF01106.17 CDF37736.1 - 8.2e-28 96.4 0.3 1.4e-19 69.9 0.1 2.1 2 0 0 2 2 2 2 NifU-like domain SDA1 PF05285.12 CDF37737.1 - 3.1e-54 184.7 27.2 3.1e-54 184.7 27.2 2.6 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 CDF37737.1 - 6.7e-08 32.7 0.0 2e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Fis1_TPR_C PF14853.6 CDF37738.1 - 7.3e-18 64.4 0.1 1.3e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CDF37738.1 - 1.5e-10 40.5 0.0 3.3e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 CDF37738.1 - 0.00015 21.6 0.1 0.00052 19.9 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF37738.1 - 0.068 13.8 0.2 0.22 12.2 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PGM_PMM_I PF02878.16 CDF37739.1 - 3.3e-35 120.8 0.0 7.2e-35 119.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CDF37739.1 - 3.8e-24 85.3 0.0 2.8e-23 82.5 0.0 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CDF37739.1 - 6.6e-16 58.5 0.2 2.4e-15 56.7 0.2 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CDF37739.1 - 0.0078 16.4 0.0 0.036 14.3 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain tRNA-synt_1 PF00133.22 CDF37740.1 - 1.2e-165 552.2 3.4 1.4e-132 443.0 0.9 3.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDF37740.1 - 4.5e-36 124.1 0.0 8.5e-36 123.2 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDF37740.1 - 5.6e-23 81.3 1.1 7.9e-12 44.6 0.7 3.2 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CDF37740.1 - 4.3e-11 42.7 0.0 8.7e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 CDF37740.1 - 2e-05 24.1 0.0 0.0008 18.8 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDF37740.1 - 0.0011 18.0 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (K) CpeS PF09367.10 CDF37741.1 - 1.1e-53 181.6 0.0 1.4e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 CpeS-like protein LSM PF01423.22 CDF37742.1 - 2.4e-14 52.7 0.1 3.1e-14 52.4 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDF37742.1 - 0.0028 17.7 0.0 0.0037 17.4 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 CDF37742.1 - 0.08 12.6 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Hfq protein G6PD_C PF02781.16 CDF37744.1 - 4.9e-111 370.6 0.0 5.9e-111 370.3 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CDF37744.1 - 1.8e-27 97.1 0.0 3.2e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain JAB PF01398.21 CDF37745.1 - 2.5e-26 92.0 0.1 4.4e-26 91.2 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDF37745.1 - 3e-16 59.8 0.1 9.5e-16 58.2 0.0 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 CDF37745.1 - 0.0022 18.1 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) ubiquitin PF00240.23 CDF37748.1 - 1.1e-08 34.7 0.0 1.3e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 CDF37748.1 - 4e-05 24.0 0.0 0.00025 21.4 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 CDF37748.1 - 0.003 17.4 0.1 0.018 14.9 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Proteasome PF00227.26 CDF37749.1 - 3.9e-47 160.2 0.1 5.5e-47 159.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF37749.1 - 1.5e-15 56.5 0.1 2.7e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature WD40 PF00400.32 CDF37752.1 - 5.7e-05 23.8 6.6 0.84 10.6 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat UL41A PF17591.2 CDF37752.1 - 0.052 13.6 0.0 0.089 12.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL41A Phage_tail_S PF05069.13 CDF37753.1 - 0.09 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Phage virion morphogenesis family EF-hand_1 PF00036.32 CDF37754.1 - 2.4e-13 48.6 1.2 5.6e-07 28.7 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CDF37754.1 - 1.3e-12 47.9 0.0 1.9e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CDF37754.1 - 1e-11 44.5 0.4 3e-06 27.0 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDF37754.1 - 2e-11 42.9 3.2 9.5e-06 25.1 0.2 2.7 2 1 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDF37754.1 - 1.1e-09 37.3 3.3 8.7e-05 21.8 0.1 2.6 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 CDF37754.1 - 0.034 14.0 0.4 3.9 7.4 0.0 2.2 2 0 0 2 2 2 0 EF hand Mrx7 PF10906.8 CDF37754.1 - 0.051 13.8 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 MIOREX complex component 7 ABC_trans_CmpB PF06541.11 CDF37754.1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Putative ABC-transporter type IV DHQ_synthase PF01761.20 CDF37755.1 - 2.3e-104 348.2 0.0 2.9e-104 347.9 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 CDF37755.1 - 8.3e-16 58.4 3.3 7.7e-15 55.3 3.3 2.0 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 CDF37755.1 - 3.4e-09 36.0 3.2 3.4e-09 36.0 3.2 1.6 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase DUF1764 PF08576.10 CDF37756.1 - 9.3e-13 48.9 3.0 9.3e-13 48.9 3.0 3.2 2 1 1 3 3 3 1 Eukaryotic protein of unknown function (DUF1764) Spt5_N PF11942.8 CDF37756.1 - 4.5 8.3 15.3 0.92 10.5 2.6 2.6 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Peptidase_M76 PF09768.9 CDF37757.1 - 5.2e-63 211.9 3.7 5.8e-63 211.7 3.7 1.0 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M90 PF06167.12 CDF37757.1 - 0.099 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Tox-MPTase2 PF15638.6 CDF37757.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase toxin 2 SprT-like PF10263.9 CDF37757.1 - 0.15 11.9 0.9 0.25 11.2 0.7 1.6 1 1 0 1 1 1 0 SprT-like family Branch PF02485.21 CDF37758.1 - 1.1e-34 120.0 1.1 1.6e-34 119.6 1.1 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Cys_Met_Meta_PP PF01053.20 CDF37760.1 - 8.2e-107 357.0 0.0 9.2e-107 356.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDF37760.1 - 0.00023 20.3 0.0 0.00036 19.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CDF37760.1 - 0.00032 20.1 0.4 0.00073 19.0 0.4 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CDF37760.1 - 0.017 14.4 0.1 0.087 12.1 0.0 1.9 2 0 0 2 2 2 0 Beta-eliminating lyase tRNA-synt_1 PF00133.22 CDF37762.1 - 5.1e-187 622.8 0.0 6.1e-187 622.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDF37762.1 - 7.6e-29 100.6 0.0 1.8e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDF37762.1 - 7.8e-18 64.4 0.0 7e-09 34.9 0.0 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.14 CDF37762.1 - 3e-06 27.0 3.1 7.1e-06 25.8 3.1 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1_2 PF13603.6 CDF37762.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 Transket_pyr PF02779.24 CDF37763.1 - 6.7e-42 143.2 0.0 9.1e-42 142.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDF37763.1 - 7.6e-34 116.3 0.0 1.6e-33 115.2 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain GNT-I PF03071.15 CDF37764.1 - 1.1e-96 324.2 0.1 1.8e-96 323.6 0.1 1.2 1 0 0 1 1 1 1 GNT-I family MGAT2 PF05060.14 CDF37764.1 - 3.7e-05 23.0 0.2 0.02 14.0 0.1 2.2 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) bVLRF1 PF18826.1 CDF37765.1 - 1.5e-16 60.6 2.1 2e-16 60.2 0.9 1.8 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor zf-C2H2_4 PF13894.6 CDF37765.1 - 0.024 15.4 1.2 0.024 15.4 1.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CDF37765.1 - 0.025 14.9 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 CDF37765.1 - 0.051 14.0 0.0 0.085 13.3 0.0 1.4 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 CDF37765.1 - 0.077 13.5 2.7 0.17 12.4 2.7 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF629 PF04780.12 CDF37765.1 - 0.13 10.8 0.1 0.17 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) MMR_HSR1 PF01926.23 CDF37768.1 - 1.4e-43 147.6 0.1 1e-20 73.9 0.0 3.2 2 1 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF37768.1 - 2.2e-20 72.8 0.2 1.1e-09 38.0 0.0 4.1 4 0 0 4 4 4 3 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDF37768.1 - 1.1e-16 61.0 1.3 1.1e-05 25.1 0.1 4.3 3 1 0 3 3 3 3 Elongation factor Tu GTP binding domain KH_dom-like PF14714.6 CDF37768.1 - 1.1e-12 48.0 0.0 6.4e-12 45.6 0.0 2.3 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal RsgA_GTPase PF03193.16 CDF37768.1 - 1.6e-10 41.2 1.0 0.036 14.0 0.0 4.3 4 0 0 4 4 4 2 RsgA GTPase Roc PF08477.13 CDF37768.1 - 1.5e-09 38.1 0.1 0.023 14.9 0.0 4.4 3 2 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CDF37768.1 - 1e-08 35.4 3.8 0.052 13.6 0.1 4.3 4 0 0 4 4 4 2 Dynamin family Ras PF00071.22 CDF37768.1 - 4.1e-07 29.7 0.1 0.24 11.0 0.0 4.7 4 1 0 4 4 4 2 Ras family ABC_tran PF00005.27 CDF37768.1 - 9.2e-07 29.5 0.4 0.027 15.0 0.2 2.7 2 1 0 2 2 2 2 ABC transporter AIG1 PF04548.16 CDF37768.1 - 1.5e-05 24.4 0.0 0.0034 16.8 0.0 2.5 2 0 0 2 2 2 1 AIG1 family NTPase_1 PF03266.15 CDF37768.1 - 6.6e-05 22.9 0.6 0.38 10.7 0.0 3.1 3 0 0 3 3 3 2 NTPase AAA_22 PF13401.6 CDF37768.1 - 7.4e-05 23.0 0.1 0.18 12.1 0.0 3.7 3 2 0 3 3 2 1 AAA domain Arf PF00025.21 CDF37768.1 - 7.7e-05 22.2 1.2 2.4 7.6 0.0 4.3 4 1 0 4 4 4 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 CDF37768.1 - 0.00012 22.1 0.6 0.61 10.1 0.2 2.3 2 0 0 2 2 2 2 C-terminal region of MMR_HSR1 domain AAA_18 PF13238.6 CDF37768.1 - 0.00094 19.7 0.0 2.2 8.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CDF37768.1 - 0.001 18.7 2.5 0.15 11.6 0.0 3.8 3 1 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CDF37768.1 - 0.0011 19.3 0.0 0.43 11.0 0.0 2.4 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.22 CDF37768.1 - 0.0028 16.9 0.1 0.9 8.7 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Ploopntkinase3 PF18751.1 CDF37768.1 - 0.0044 17.0 0.2 7 6.5 0.0 3.4 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 AAA_24 PF13479.6 CDF37768.1 - 0.0052 16.5 0.0 1.3 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDF37768.1 - 0.0053 17.1 1.6 3.2 8.1 0.1 3.3 2 2 1 3 3 2 1 AAA ATPase domain AAA_28 PF13521.6 CDF37768.1 - 0.0057 16.9 0.3 1.2 9.4 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDF37768.1 - 0.0069 16.6 0.6 2.9 8.0 0.0 3.4 3 1 0 3 3 3 1 AAA domain MobB PF03205.14 CDF37768.1 - 0.0069 16.3 0.4 2.1 8.3 0.0 2.7 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 CDF37768.1 - 0.0079 16.1 0.4 2.6 7.9 0.0 3.1 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 CDF37768.1 - 0.0081 15.9 0.7 30 4.3 0.0 4.0 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 CDF37768.1 - 0.0082 15.2 8.6 0.44 9.5 0.1 3.6 4 0 0 4 4 4 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CDF37768.1 - 0.011 15.6 0.0 2 8.3 0.0 3.1 4 0 0 4 4 3 0 NACHT domain AAA_29 PF13555.6 CDF37768.1 - 0.011 15.4 0.0 6.2 6.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 CDF37768.1 - 0.015 14.7 0.1 7.5 5.9 0.0 3.0 3 1 0 3 3 3 0 Bacterial TniB protein SRPRB PF09439.10 CDF37768.1 - 0.018 14.4 0.0 7.4 6.0 0.0 2.7 3 0 0 3 3 2 0 Signal recognition particle receptor beta subunit Septin PF00735.18 CDF37768.1 - 0.03 13.6 0.1 13 4.9 0.0 3.4 4 1 0 4 4 3 0 Septin PIN_5 PF08745.11 CDF37768.1 - 0.038 13.4 0.1 0.088 12.2 0.0 1.6 2 0 0 2 2 1 0 PINc domain ribonuclease AAA_14 PF13173.6 CDF37768.1 - 0.067 13.2 0.4 8.5 6.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain KTI12 PF08433.10 CDF37768.1 - 0.086 12.3 0.0 7.9 5.8 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA PF00004.29 CDF37768.1 - 0.11 12.9 0.0 19 5.7 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) GBP PF02263.19 CDF37768.1 - 0.12 11.6 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain NOG1 PF06858.14 CDF37768.1 - 0.73 9.7 4.6 3.9 7.3 0.4 3.1 2 2 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) NB-ARC PF00931.22 CDF37772.1 - 1.1e-13 51.0 0.0 2.1e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CDF37772.1 - 0.0013 19.0 0.0 0.0048 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF4407 PF14362.6 CDF37772.1 - 0.15 11.4 0.3 0.26 10.6 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cluap1 PF10234.9 CDF37772.1 - 0.15 11.4 0.9 0.36 10.2 0.9 1.6 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF713 PF05218.14 CDF37772.1 - 0.16 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF713) GCS2 PF04107.13 CDF37775.1 - 0.0022 17.4 0.1 0.0025 17.2 0.1 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase family 2(GCS2) Sigma70_r2 PF04542.14 CDF37776.1 - 7.5e-21 73.7 0.1 1.5e-20 72.7 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CDF37776.1 - 7.2e-20 70.2 0.7 1.9e-19 68.9 0.7 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r3 PF04539.16 CDF37776.1 - 9.1e-15 54.5 0.8 9.1e-10 38.5 0.2 3.4 3 0 0 3 3 3 2 Sigma-70 region 3 Sigma70_r1_2 PF00140.20 CDF37776.1 - 2.5e-06 27.4 0.0 6.7e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 Sigma70_r4_2 PF08281.12 CDF37776.1 - 0.00011 21.8 0.7 0.021 14.5 0.1 3.7 3 1 0 3 3 3 1 Sigma-70, region 4 CDO_I PF05995.12 CDF37776.1 - 0.16 11.3 0.1 0.29 10.5 0.1 1.3 1 0 0 1 1 1 0 Cysteine dioxygenase type I PAF PF15715.5 CDF37778.1 - 0.11 13.1 2.9 0.16 12.6 2.9 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain DUF3055 PF11256.8 CDF37778.1 - 0.15 12.3 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3055) SR-25 PF10500.9 CDF37779.1 - 0.65 9.6 15.4 0.7 9.5 15.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AMP-binding PF00501.28 CDF37783.1 - 7.6e-85 285.0 0.0 9.2e-85 284.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme RNA_pol_L PF01193.24 CDF37784.1 - 1e-07 31.3 0.0 1.3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_7 PF12838.7 CDF37784.1 - 0.14 12.8 2.0 0.37 11.4 2.0 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain PAP2 PF01569.21 CDF37786.1 - 1.8e-10 40.7 3.1 1.8e-10 40.7 3.1 2.6 3 0 0 3 3 3 1 PAP2 superfamily Abhydrolase_1 PF00561.20 CDF37788.1 - 6.2e-33 114.5 0.0 7.5e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF37788.1 - 5.9e-10 38.8 0.0 2.7e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDF37788.1 - 6.2e-10 40.0 0.0 9.7e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 CDF37788.1 - 0.00038 20.5 0.0 0.00082 19.5 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Ndr PF03096.14 CDF37788.1 - 0.019 13.7 0.0 0.03 13.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family Peptidase_S28 PF05577.12 CDF37788.1 - 0.021 13.7 0.0 0.034 13.0 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Ser_hydrolase PF06821.13 CDF37788.1 - 0.04 13.8 0.0 0.14 12.0 0.0 1.8 2 1 0 2 2 2 0 Serine hydrolase DnaJ PF00226.31 CDF37789.1 - 6.8e-15 54.9 0.3 1.6e-14 53.7 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 CDF37789.1 - 6.1e-11 41.6 3.3 0.01 15.9 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDF37789.1 - 5.7e-10 38.6 2.0 0.00044 19.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDF37789.1 - 1.5e-05 24.6 0.7 3.9e-05 23.2 0.7 1.8 1 0 0 1 1 1 1 TPR repeat TPR_14 PF13428.6 CDF37789.1 - 1.7e-05 25.2 0.6 2 9.5 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDF37789.1 - 0.00024 21.2 0.1 0.0038 17.3 0.2 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF37789.1 - 0.00026 21.4 1.8 0.0018 18.7 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37789.1 - 0.00063 19.9 0.5 0.01 16.1 0.2 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37789.1 - 0.0009 19.8 1.5 0.0018 18.9 0.5 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF37789.1 - 0.0022 18.0 0.2 1 9.5 0.0 2.9 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 CDF37789.1 - 0.0025 17.9 1.2 13 6.3 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat RHD3 PF05879.12 CDF37789.1 - 0.009 14.2 0.1 0.012 13.8 0.1 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) PknG_TPR PF16918.5 CDF37789.1 - 0.02 13.7 0.1 0.035 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_7 PF13176.6 CDF37789.1 - 0.045 13.8 0.2 0.74 10.0 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF37789.1 - 0.047 14.0 1.3 0.56 10.5 0.2 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 CDF37789.1 - 0.082 13.0 0.1 0.33 11.1 0.0 2.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF2207 PF09972.9 CDF37789.1 - 0.11 11.3 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HemY_N PF07219.13 CDF37789.1 - 1.2 9.3 3.4 0.67 10.2 0.2 2.2 3 0 0 3 3 3 0 HemY protein N-terminus IBR PF01485.21 CDF37790.1 - 2e-07 31.1 35.1 8.6e-06 25.9 9.7 3.7 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain Acetyltransf_10 PF13673.7 CDF37792.1 - 7.2e-10 38.9 0.0 1.9e-09 37.5 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDF37792.1 - 2.5e-08 34.2 0.0 5.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF37792.1 - 7.6e-08 32.7 0.0 1.6e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 CDF37792.1 - 7.1e-07 29.1 0.0 0.00027 20.7 0.0 3.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF37792.1 - 1.7e-06 27.9 0.0 1.3e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 CDF37792.1 - 0.00083 19.4 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CDF37792.1 - 0.0043 17.1 0.0 0.012 15.7 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 CDF37792.1 - 0.059 13.1 0.0 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_16 PF05301.11 CDF37792.1 - 0.15 11.8 0.0 0.47 10.2 0.0 1.8 2 0 0 2 2 2 0 GNAT acetyltransferase, Mec-17 Acetyltransf_10 PF13673.7 CDF37793.1 - 2.3e-09 37.3 0.0 5e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDF37793.1 - 7e-08 32.7 0.0 1.4e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF37793.1 - 1.9e-07 31.4 0.0 4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF37793.1 - 6.6e-06 26.0 0.0 3.1e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_18 PF18014.1 CDF37793.1 - 7.5e-06 25.8 0.0 0.00077 19.3 0.0 2.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDF37793.1 - 0.0018 18.4 0.0 0.0036 17.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CDF37793.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 CDF37793.1 - 0.16 11.7 0.0 0.44 10.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ DDE_3 PF13358.6 CDF37794.1 - 1.3e-11 44.4 0.0 1.6e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF37795.1 - 2.2e-11 43.4 0.0 6.7e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 Tc3 transposase DDE_3 PF13358.6 CDF37795.1 - 7e-11 42.1 0.0 1.3e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.6 CDF37795.1 - 2.5e-07 30.3 1.3 7.1e-07 28.9 0.0 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF37795.1 - 0.0012 19.4 0.4 0.0064 17.1 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.6 CDF37795.1 - 0.06 12.9 0.0 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_Tnp_Tc3_2 PF01498.18 CDF37795.1 - 0.072 13.3 3.8 0.06 13.6 2.0 1.9 2 0 0 2 2 2 0 Transposase HTH_11 PF08279.12 CDF37795.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 HTH domain CCT PF06203.14 CDF37798.1 - 3.4e-12 46.2 1.3 3.4e-12 46.2 1.3 1.6 2 0 0 2 2 2 1 CCT motif WD40 PF00400.32 CDF37799.1 - 4.3e-61 201.4 44.0 3.3e-06 27.7 0.2 10.7 10 0 0 10 10 10 9 WD domain, G-beta repeat TIR_2 PF13676.6 CDF37799.1 - 8.8e-18 65.0 0.0 8.5e-17 61.8 0.0 2.7 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF37799.1 - 9.1e-17 61.1 0.0 1.9e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF37799.1 - 7.6e-09 35.8 15.6 0.26 11.6 0.2 7.7 1 1 9 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.20 CDF37799.1 - 1.6e-07 31.3 0.0 3.6e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 TIR domain Nup160 PF11715.8 CDF37799.1 - 0.00085 18.1 19.5 2.3 6.8 0.0 8.7 4 3 2 10 10 10 2 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF37799.1 - 0.0017 18.7 0.0 0.0044 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIR-like PF10137.9 CDF37799.1 - 0.09 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Hemerythrin PF01814.23 CDF37803.1 - 6.7e-19 68.8 16.3 7.9e-08 33.0 0.2 3.4 2 1 1 3 3 3 3 Hemerythrin HHE cation binding domain zinc_ribbon_6 PF14599.6 CDF37803.1 - 8.7e-18 64.1 2.1 8.7e-18 64.1 2.1 3.4 3 0 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.12 CDF37803.1 - 5.8e-17 62.0 21.5 5.8e-17 62.0 21.5 4.4 2 1 0 2 2 2 1 CHY zinc finger zf-RING_2 PF13639.6 CDF37803.1 - 3.1e-07 30.6 4.9 3.1e-07 30.6 4.9 5.8 7 0 0 7 7 7 1 Ring finger domain zf-RING_5 PF14634.6 CDF37803.1 - 0.00012 22.0 6.5 0.00012 22.0 6.5 5.9 5 1 2 7 7 7 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDF37803.1 - 0.0043 16.9 6.4 0.0043 16.9 6.4 4.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Ribosomal_L5e PF17144.4 CDF37805.1 - 1.6e-84 281.9 0.5 2.8e-84 281.1 0.5 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CDF37805.1 - 1.6e-31 109.1 3.5 1.6e-31 109.1 3.5 2.4 3 0 0 3 3 3 1 Ribosomal L18 C-terminal region GCR1_C PF12550.8 CDF37805.1 - 0.0097 16.2 4.4 0.19 12.1 2.6 2.4 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes ABC_tran PF00005.27 CDF37806.1 - 1.8e-24 86.8 0.0 3.8e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF37806.1 - 8.4e-13 48.8 0.4 4.4e-07 30.0 0.1 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 CDF37806.1 - 2.1e-05 25.1 0.1 6.1e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) SMC_N PF02463.19 CDF37806.1 - 0.02 14.3 0.0 0.47 9.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RecA PF00154.21 CDF37806.1 - 0.077 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_23 PF13476.6 CDF37806.1 - 0.13 12.8 0.1 0.25 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain ABATE PF07336.11 CDF37807.1 - 0.06 14.0 0.0 0.48 11.1 0.0 2.5 2 0 0 2 2 2 0 Putative stress-induced transcription regulator DIMCO_N PF16844.5 CDF37807.1 - 0.16 12.3 0.1 9.8 6.6 0.0 2.8 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal Chorion_3 PF05387.11 CDF37807.1 - 0.21 11.2 0.1 0.33 10.6 0.1 1.2 1 0 0 1 1 1 0 Chorion family 3 zf-RING_2 PF13639.6 CDF37808.1 - 1.4e-11 44.5 5.0 2.5e-09 37.3 1.1 2.4 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.7 CDF37808.1 - 7.8e-10 38.9 2.1 1e-08 35.3 0.5 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDF37808.1 - 8.9e-09 34.9 4.2 1.3e-05 24.8 0.1 3.4 3 0 0 3 3 3 2 RING-like zinc finger zf-C3HC4 PF00097.25 CDF37808.1 - 1.2e-08 34.6 3.2 3.7e-07 29.9 0.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF37808.1 - 6.7e-08 32.3 3.6 1.3e-06 28.1 0.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDF37808.1 - 1.3e-07 31.6 1.0 3.3e-07 30.3 0.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CDF37808.1 - 1.9e-06 27.7 4.5 0.0069 16.4 0.0 3.5 3 0 0 3 3 3 2 RING-type zinc-finger zf-RING_5 PF14634.6 CDF37808.1 - 1.1e-05 25.3 6.8 1.2e-05 25.1 0.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF37808.1 - 3.6e-05 23.5 6.4 0.0012 18.6 0.7 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDF37808.1 - 7.2e-05 22.6 5.2 0.00062 19.6 0.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDF37808.1 - 0.00045 20.3 4.2 0.0028 17.8 1.0 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING RINGv PF12906.7 CDF37808.1 - 0.0063 16.6 1.2 0.0063 16.6 1.2 2.2 2 1 0 2 2 2 1 RING-variant domain DUF1644 PF07800.12 CDF37808.1 - 0.017 15.2 0.7 0.043 13.9 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) DUF4834 PF16118.5 CDF37808.1 - 0.028 15.4 0.1 0.089 13.8 0.0 1.8 1 1 0 2 2 1 0 Domain of unknown function (DUF4834) zf-TFIIIC PF12660.7 CDF37808.1 - 0.045 13.7 1.5 0.15 12.1 0.1 2.1 2 0 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex FANCL_C PF11793.8 CDF37808.1 - 0.046 13.9 5.6 0.46 10.7 2.9 2.9 2 1 0 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CDF37808.1 - 0.056 13.1 0.7 0.056 13.1 0.7 1.7 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type MASE2 PF05230.11 CDF37808.1 - 0.095 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 MASE2 domain DUF5321 PF17254.2 CDF37808.1 - 0.097 12.1 0.2 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5321) Prok-RING_1 PF14446.6 CDF37808.1 - 0.15 12.0 4.8 24 4.9 0.2 3.5 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-Nse PF11789.8 CDF37808.1 - 0.2 11.5 4.7 0.86 9.5 1.7 2.7 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 CDF37808.1 - 2.8 7.8 7.2 0.95 9.3 0.6 2.5 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain DDHD PF02862.17 CDF37809.1 - 1.3e-09 38.6 0.0 1.6e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 DDHD domain Lipase_3 PF01764.25 CDF37810.1 - 1.5e-20 73.5 0.0 2.7e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Folate_carrier PF01770.18 CDF37810.1 - 0.092 11.5 0.2 0.14 10.9 0.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier SfLAP PF11139.8 CDF37810.1 - 0.1 12.0 0.7 0.21 11.0 0.7 1.4 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein Esterase PF00756.20 CDF37810.1 - 0.15 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Shisa PF13908.6 CDF37813.1 - 0.0044 17.3 5.8 0.0044 17.3 5.8 1.6 1 1 0 2 2 2 1 Wnt and FGF inhibitory regulator PRIMA1 PF16101.5 CDF37813.1 - 0.072 13.1 4.1 0.12 12.4 4.1 1.4 1 1 0 1 1 1 0 Proline-rich membrane anchor 1 Prominin PF05478.11 CDF37813.1 - 0.73 7.7 4.6 0.95 7.3 4.6 1.2 1 0 0 1 1 1 0 Prominin ETRAMP PF09716.10 CDF37813.1 - 1.7 8.7 8.6 0.091 12.8 0.3 2.2 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cadherin_C_2 PF16492.5 CDF37813.1 - 2 9.2 7.5 11 6.8 6.7 2.0 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Metallophos PF00149.28 CDF37814.1 - 1.9e-16 61.2 0.7 2.7e-16 60.7 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD PF09423.10 CDF37814.1 - 0.003 16.6 0.0 0.72 8.8 0.0 2.2 2 0 0 2 2 2 2 PhoD-like phosphatase Metallophos_2 PF12850.7 CDF37814.1 - 0.0061 16.8 0.2 0.015 15.5 0.2 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Diacid_rec PF05651.13 CDF37814.1 - 0.11 12.2 0.4 0.52 10.0 0.0 2.1 2 1 0 2 2 2 0 Putative sugar diacid recognition Retrotran_gag_2 PF14223.6 CDF37815.1 - 3e-33 114.4 0.3 5.7e-33 113.5 0.0 1.6 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF37815.1 - 2.3e-21 76.2 0.1 1.8e-20 73.3 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF37815.1 - 8.2e-08 32.0 0.1 5e-07 29.5 0.0 2.3 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF37815.1 - 0.0014 18.3 0.0 0.0036 17.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF37815.1 - 0.18 11.6 1.8 0.53 10.1 1.8 1.8 1 0 0 1 1 1 0 Zinc knuckle Retrotran_gag_2 PF14223.6 CDF37816.1 - 7e-33 113.2 0.4 1.2e-32 112.4 0.4 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF37816.1 - 1.9e-20 73.3 0.0 6.5e-20 71.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF37816.1 - 3.3e-07 30.1 0.0 1.1e-06 28.4 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF37816.1 - 0.0028 17.4 0.0 0.0076 16.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF37816.1 - 0.28 10.9 1.7 0.99 9.2 1.7 2.0 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDF37816.1 - 0.36 10.7 2.9 1.1 9.1 2.9 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF37816.1 - 0.43 10.7 3.9 0.97 9.6 3.9 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF3516 PF12029.8 CDF37817.1 - 0.25 10.4 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) DUF563 PF04577.14 CDF37818.1 - 2.1e-10 41.1 0.0 4.5e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) GMC_oxred_N PF00732.19 CDF37821.1 - 4.9e-41 141.0 0.3 3.9e-40 138.1 0.3 2.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CDF37821.1 - 2.5e-20 73.4 0.0 5.9e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CDF37821.1 - 2.3e-07 30.7 1.6 2.2e-06 27.5 1.6 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDF37821.1 - 0.00028 20.1 0.0 0.0011 18.2 0.0 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CDF37821.1 - 0.0007 18.8 1.3 0.004 16.3 1.3 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CDF37821.1 - 0.0014 18.0 0.0 0.95 8.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDF37821.1 - 0.0027 17.9 1.0 0.007 16.6 1.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CDF37821.1 - 0.033 14.2 0.2 0.14 12.1 0.1 2.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Beta_helix_2 PF18835.1 CDF37821.1 - 0.043 13.6 0.4 0.66 9.8 0.0 2.9 3 0 0 3 3 3 0 Beta helix repeat of Inulin fructotransferase Thi4 PF01946.17 CDF37821.1 - 0.068 12.4 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 CDF37821.1 - 0.073 12.3 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CDF37821.1 - 0.077 11.8 0.1 0.12 11.3 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Abhydrolase_1 PF00561.20 CDF37822.1 - 1.5e-14 54.3 0.0 1.8e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF37822.1 - 5.5e-05 23.9 0.0 5.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family An_peroxidase PF03098.15 CDF37823.1 - 5e-121 404.9 0.2 6e-121 404.6 0.2 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Sel1 PF08238.12 CDF37825.1 - 3e-48 161.2 11.0 2.4e-07 31.2 0.0 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.6 CDF37825.1 - 3.4e-12 46.2 19.0 0.42 11.4 0.0 8.8 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37825.1 - 9.5e-11 42.2 24.3 0.0031 18.1 0.7 5.9 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37825.1 - 5e-08 32.8 0.1 4.3 7.9 0.0 7.3 6 3 1 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF37825.1 - 4e-06 26.5 19.0 1.5 9.0 0.1 7.9 5 2 2 7 7 7 3 Tetratricopeptide repeat NSF PF02071.20 CDF37825.1 - 3.6e-05 23.7 7.2 48 5.4 0.1 7.3 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat TPR_14 PF13428.6 CDF37825.1 - 8.6e-05 23.1 27.8 16 6.7 1.0 8.1 5 3 2 8 8 8 0 Tetratricopeptide repeat MIT PF04212.18 CDF37825.1 - 0.00061 19.8 5.6 12 6.1 0.0 5.6 6 0 0 6 6 6 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 CDF37825.1 - 0.0033 17.2 8.6 29 4.7 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDF37825.1 - 0.014 15.0 2.2 28 4.5 0.0 4.7 4 0 0 4 4 4 0 TPR repeat TPR_2 PF07719.17 CDF37825.1 - 0.057 13.5 23.6 20 5.6 0.2 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat ComR_TPR PF18710.1 CDF37825.1 - 0.12 11.9 0.0 18 4.8 0.0 2.7 3 0 0 3 3 3 0 ComR tetratricopeptide HEPN_Apea PF18739.1 CDF37825.1 - 0.21 12.1 0.1 11 6.6 0.0 3.5 3 1 1 4 4 4 0 Apea-like HEPN Methyltransf_29 PF03141.16 CDF37825.1 - 0.23 9.9 0.1 0.62 8.5 0.1 1.7 1 1 1 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase HEAT_2 PF13646.6 CDF37825.1 - 1.1 9.7 14.7 5.6 7.4 2.7 3.8 1 1 1 3 3 3 0 HEAT repeats Sel1 PF08238.12 CDF37826.1 - 7.7e-61 201.2 17.4 1.1e-06 29.1 0.0 11.1 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.6 CDF37826.1 - 9.8e-16 57.3 22.6 0.11 13.1 0.1 11.6 10 2 1 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37826.1 - 4.1e-12 46.5 31.7 0.033 14.8 0.2 9.1 4 2 6 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37826.1 - 6.6e-08 32.4 0.5 22 5.7 0.1 8.9 9 2 0 9 9 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF37826.1 - 1.4e-07 31.0 23.2 5.1 7.4 0.0 10.0 8 3 3 11 11 11 3 Tetratricopeptide repeat MIT PF04212.18 CDF37826.1 - 3.5e-05 23.8 6.6 18 5.5 0.0 7.0 8 0 0 8 8 7 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 CDF37826.1 - 5.5e-05 23.7 29.6 34 5.6 0.3 10.4 8 3 3 11 11 11 0 Tetratricopeptide repeat NSF PF02071.20 CDF37826.1 - 0.0049 17.3 14.4 70 4.9 0.1 8.6 9 0 0 9 9 8 0 Aromatic-di-Alanine (AdAR) repeat Exonuc_VII_S PF02609.16 CDF37826.1 - 0.022 14.8 4.9 9.7 6.3 0.0 6.3 8 0 0 8 8 8 0 Exonuclease VII small subunit TPR_1 PF00515.28 CDF37826.1 - 0.023 14.5 15.4 21 5.1 0.0 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF37826.1 - 0.028 14.6 3.3 19 5.6 0.0 4.6 4 2 2 6 6 6 0 Arginine decarboxylase helical bundle domain TPR_2 PF07719.17 CDF37826.1 - 0.057 13.5 25.9 33 4.9 0.0 9.8 10 1 1 11 11 11 0 Tetratricopeptide repeat SNAP PF14938.6 CDF37826.1 - 0.1 12.0 4.0 0.49 9.8 0.7 3.3 3 1 1 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 CDF37826.1 - 0.44 10.3 9.9 69 3.3 0.0 5.8 6 0 0 6 6 6 0 TPR repeat CotH PF08757.11 CDF37831.1 - 7.1e-28 98.1 11.0 9.9e-28 97.6 11.0 1.2 1 0 0 1 1 1 1 CotH kinase protein HAD PF12710.7 CDF37831.1 - 0.0036 17.7 0.0 0.0076 16.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase FbpA PF05833.11 CDF37831.1 - 0.043 12.6 1.0 0.07 11.9 1.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Aha1_N PF09229.11 CDF37832.1 - 6.8e-20 71.7 0.0 1.3e-19 70.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal Cpn60_TCP1 PF00118.24 CDF37834.1 - 0.0013 17.4 0.0 0.0014 17.4 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family 2-oxoacid_dh PF00198.23 CDF37836.1 - 6.4e-32 110.9 0.0 7.1e-32 110.7 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) B3 PF02362.21 CDF37836.1 - 0.093 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 B3 DNA binding domain Biotin_lipoyl PF00364.22 CDF37838.1 - 5e-18 64.7 0.0 6.9e-18 64.3 0.0 1.2 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CDF37838.1 - 1.4e-05 25.3 0.0 3e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CDF37838.1 - 0.027 14.3 0.0 1.1 9.2 0.0 2.3 1 1 1 2 2 2 0 Biotin-lipoyl like HlyD_D23 PF16576.5 CDF37838.1 - 0.088 12.0 0.1 0.88 8.8 0.0 1.9 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Hira PF07569.11 CDF37842.1 - 2.2e-30 106.1 0.1 6.4e-30 104.5 0.0 1.8 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 CDF37842.1 - 1.4e-25 89.0 18.7 9.5e-08 32.6 0.6 7.1 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF37842.1 - 5.9e-15 55.3 0.1 0.0036 17.6 0.0 6.3 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 CDF37842.1 - 0.2 11.5 0.6 0.47 10.3 0.6 1.6 1 0 0 1 1 1 0 HIRA B motif Glyco_hydro_14 PF01373.17 CDF37844.1 - 1e-84 284.8 0.0 1.2e-84 284.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 rve PF00665.26 CDF37845.1 - 4.1e-21 75.4 0.0 7.8e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Retrotran_gag_2 PF14223.6 CDF37845.1 - 2.7e-08 33.6 0.0 5.5e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type gag_pre-integrs PF13976.6 CDF37845.1 - 1.3e-05 24.9 0.1 3.7e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF37845.1 - 0.0007 19.3 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Peptidase_C48 PF02902.19 CDF37848.1 - 7.3e-30 104.4 0.5 8.3e-30 104.2 0.5 1.0 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Propeptide_C1 PF08127.13 CDF37848.1 - 0.066 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C1 propeptide GYR PF02756.14 CDF37848.1 - 0.23 11.2 0.7 0.45 10.3 0.7 1.5 1 0 0 1 1 1 0 GYR motif XPG_N PF00752.17 CDF37850.1 - 8.3e-30 103.3 0.0 1.8e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CDF37850.1 - 6.3e-28 97.0 0.1 1.2e-27 96.1 0.1 1.5 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 CDF37850.1 - 0.0022 18.6 0.0 0.006 17.2 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold DEAD PF00270.29 CDF37851.1 - 1.6e-45 155.0 0.0 3.3e-45 154.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF37851.1 - 4.2e-25 88.2 0.1 2.3e-24 85.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDF37851.1 - 9.9e-18 64.1 0.0 1.8e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CDF37851.1 - 2.8e-05 24.2 0.0 5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NB-ARC PF00931.22 CDF37855.1 - 1.2e-14 54.1 0.0 2.3e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CDF37855.1 - 0.067 13.5 0.0 0.26 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain PTN13_u3 PF16599.5 CDF37855.1 - 0.08 13.0 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ NACHT PF05729.12 CDF37855.1 - 0.13 12.2 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 NACHT domain p450 PF00067.22 CDF37857.1 - 2.2e-57 194.9 0.0 2.9e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HEAT PF02985.22 CDF37864.1 - 2.6e-20 70.8 2.1 0.00048 20.1 0.0 6.9 6 0 0 6 6 6 4 HEAT repeat HEAT_EZ PF13513.6 CDF37864.1 - 6.3e-08 33.0 4.6 3.9e-07 30.4 0.1 4.0 4 1 1 5 5 5 1 HEAT-like repeat HEAT_2 PF13646.6 CDF37864.1 - 1.2e-06 28.8 2.0 5.2e-05 23.5 0.0 3.8 3 1 0 3 3 3 1 HEAT repeats Vac14_Fab1_bd PF12755.7 CDF37864.1 - 2.6e-05 24.7 0.0 0.13 12.8 0.0 3.5 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 CDF37864.1 - 0.00026 20.6 0.0 0.68 9.5 0.0 3.0 3 0 0 3 3 3 2 CLASP N terminal TAF6_C PF07571.13 CDF37864.1 - 0.0016 18.7 0.1 0.84 10.0 0.0 4.5 3 1 2 5 5 5 1 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 CDF37864.1 - 0.075 13.1 0.2 0.46 10.5 0.0 2.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 ArsA_ATPase PF02374.15 CDF37865.1 - 1.1e-186 619.2 0.0 9e-93 310.8 0.0 2.0 2 0 0 2 2 2 2 Anion-transporting ATPase AAA_31 PF13614.6 CDF37865.1 - 1.3e-26 93.6 0.2 5.1e-13 49.3 0.0 3.4 2 1 0 2 2 2 2 AAA domain CbiA PF01656.23 CDF37865.1 - 1.3e-25 89.9 0.0 2.7e-11 43.6 0.0 3.2 2 2 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 CDF37865.1 - 1.4e-13 50.9 0.2 1.4e-06 28.0 0.1 2.5 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 CDF37865.1 - 3.3e-12 46.5 1.6 9.7e-05 22.1 0.1 4.1 4 0 0 4 4 4 2 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 CDF37865.1 - 7.7e-11 41.9 0.1 0.00013 21.5 0.0 2.6 2 0 0 2 2 2 2 Cellulose biosynthesis protein BcsQ ParA PF10609.9 CDF37865.1 - 1e-09 38.3 8.1 0.0001 21.9 0.5 3.2 3 0 0 3 3 3 2 NUBPL iron-transfer P-loop NTPase Zeta_toxin PF06414.12 CDF37865.1 - 3.6e-06 26.4 0.1 0.095 12.0 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin NB-ARC PF00931.22 CDF37865.1 - 2.4e-05 23.7 1.7 0.14 11.4 0.2 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_16 PF13191.6 CDF37865.1 - 2.4e-05 24.8 0.2 0.21 12.0 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain VirC1 PF07015.11 CDF37865.1 - 3.1e-05 23.4 0.3 0.016 14.5 0.0 2.5 2 0 0 2 2 2 1 VirC1 protein MeaB PF03308.16 CDF37865.1 - 4.6e-05 22.5 1.4 0.0051 15.8 0.0 3.3 4 0 0 4 4 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CDF37865.1 - 0.00014 22.4 1.8 0.23 12.0 0.1 3.0 3 0 0 3 3 2 2 AAA domain DUF1611 PF07755.11 CDF37865.1 - 0.00031 20.1 0.1 0.054 12.8 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1611_C) P-loop domain AAA_24 PF13479.6 CDF37865.1 - 0.00032 20.5 0.2 0.066 12.9 0.0 2.7 2 2 0 2 2 2 1 AAA domain MipZ PF09140.11 CDF37865.1 - 0.00035 19.9 2.8 0.44 9.8 0.1 3.1 4 0 0 4 4 3 2 ATPase MipZ CTP_synth_N PF06418.14 CDF37865.1 - 0.00061 19.2 2.5 0.042 13.2 0.1 3.2 3 0 0 3 3 3 1 CTP synthase N-terminus AAA_25 PF13481.6 CDF37865.1 - 0.001 18.7 5.4 0.16 11.5 1.3 3.5 3 1 0 3 3 3 1 AAA domain T2SSE PF00437.20 CDF37865.1 - 0.0024 17.0 0.1 0.09 11.8 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein PIF1 PF05970.14 CDF37865.1 - 0.0037 16.5 0.6 0.39 9.8 0.1 2.3 2 0 0 2 2 2 1 PIF1-like helicase ATP_bind_1 PF03029.17 CDF37865.1 - 0.0043 16.9 7.4 0.052 13.3 0.3 3.2 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 CDF37865.1 - 0.0044 16.8 0.1 1.6 8.5 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CDF37865.1 - 0.0075 16.6 0.2 3.9 7.9 0.1 2.5 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 CDF37865.1 - 0.0084 15.9 3.5 0.25 11.0 0.8 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDF37865.1 - 0.012 15.8 0.3 2.5 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 CDF37865.1 - 0.017 14.6 0.0 2.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 DUF728 PF05304.12 CDF37865.1 - 0.035 13.9 0.2 0.47 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF728) STAT_int PF02865.17 CDF37865.1 - 0.044 14.2 0.2 13 6.2 0.0 2.9 2 0 0 2 2 2 0 STAT protein, protein interaction domain HTH_ParB PF17762.1 CDF37865.1 - 0.045 13.6 0.0 4.8 7.1 0.0 3.1 2 0 0 2 2 2 0 HTH domain found in ParB protein ABC_tran PF00005.27 CDF37865.1 - 0.063 13.8 0.1 6.2 7.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Mur_ligase_M PF08245.12 CDF37865.1 - 0.11 12.5 1.4 2.9 7.9 0.2 2.4 2 0 0 2 2 2 0 Mur ligase middle domain ResIII PF04851.15 CDF37865.1 - 0.11 12.5 0.1 7.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit APS_kinase PF01583.20 CDF37865.1 - 0.12 12.3 5.2 9 6.2 0.1 3.9 4 0 0 4 4 4 0 Adenylylsulphate kinase DUF2075 PF09848.9 CDF37865.1 - 0.24 10.6 0.4 11 5.1 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) FTHFS PF01268.19 CDF37865.1 - 0.4 8.8 2.8 4.4 5.4 0.1 2.9 3 0 0 3 3 3 0 Formate--tetrahydrofolate ligase NTPase_1 PF03266.15 CDF37865.1 - 0.51 10.2 6.9 1.6 8.6 0.2 3.1 3 0 0 3 3 3 0 NTPase NACHT PF05729.12 CDF37865.1 - 4.6 7.1 6.5 5.1 7.0 0.6 2.4 2 0 0 2 2 2 0 NACHT domain Leo1 PF04004.13 CDF37866.1 - 6e-15 55.5 0.3 6e-15 55.5 0.3 1.8 1 1 1 2 2 2 1 Leo1-like protein DUF4407 PF14362.6 CDF37866.1 - 1.8 7.8 6.2 2.3 7.5 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1758 PF05585.12 CDF37867.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Phosphorylase PF00343.20 CDF37868.1 - 9.8e-301 999.3 0.0 1.2e-300 999.0 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Terpene_synth_C PF03936.16 CDF37868.1 - 0.1 11.9 0.0 0.3 10.4 0.0 1.7 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain ABC_membrane PF00664.23 CDF37870.1 - 9.5e-114 379.7 26.8 5.5e-63 213.2 14.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDF37870.1 - 7.6e-70 233.8 0.2 2.5e-35 122.0 0.1 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDF37870.1 - 1e-14 54.5 0.0 5.3e-06 26.0 0.1 3.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA PF00004.29 CDF37870.1 - 1.4e-06 28.7 0.7 0.4 11.1 0.1 4.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF37870.1 - 1.8e-06 28.2 1.1 0.06 13.6 0.1 3.5 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CDF37870.1 - 2.1e-06 27.7 0.0 0.015 15.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CDF37870.1 - 5.8e-06 26.8 3.0 0.033 14.6 0.1 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 CDF37870.1 - 6.5e-06 26.2 0.1 0.074 13.1 0.1 4.1 4 1 0 4 4 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CDF37870.1 - 1.1e-05 24.8 0.0 0.12 11.6 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin ABC_ATPase PF09818.9 CDF37870.1 - 1.7e-05 23.8 0.7 0.096 11.5 0.1 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class DUF87 PF01935.17 CDF37870.1 - 3.5e-05 24.0 0.3 0.52 10.4 0.0 3.0 3 0 0 3 3 3 2 Helicase HerA, central domain Rad17 PF03215.15 CDF37870.1 - 7e-05 22.8 0.0 0.19 11.6 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_29 PF13555.6 CDF37870.1 - 7.1e-05 22.5 0.5 0.12 12.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 CDF37870.1 - 9.9e-05 22.2 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain G-alpha PF00503.20 CDF37870.1 - 0.00016 21.0 0.0 0.33 10.0 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_30 PF13604.6 CDF37870.1 - 0.00016 21.5 1.2 0.67 9.6 0.3 3.4 3 1 0 3 3 3 2 AAA domain DUF815 PF05673.13 CDF37870.1 - 0.0016 17.6 0.0 0.55 9.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 CDF37870.1 - 0.002 17.7 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region PRK PF00485.18 CDF37870.1 - 0.0053 16.5 0.0 3.2 7.4 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_21 PF13304.6 CDF37870.1 - 0.013 15.3 0.1 15 5.3 0.0 3.5 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.22 CDF37870.1 - 0.014 15.8 0.0 6.1 7.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATP-synt_ab PF00006.25 CDF37870.1 - 0.03 14.0 0.0 1.6 8.3 0.0 2.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 CDF37870.1 - 0.03 14.1 0.0 3.2 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDF37870.1 - 0.067 13.4 0.1 23 5.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF37870.1 - 0.068 12.3 0.1 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 CDF37870.1 - 0.081 13.4 0.0 5.3 7.5 0.0 2.6 3 0 0 3 3 2 0 AAA domain TniB PF05621.11 CDF37870.1 - 0.088 12.2 0.1 3.9 6.8 0.0 3.0 4 0 0 4 4 4 0 Bacterial TniB protein AAA_18 PF13238.6 CDF37870.1 - 0.09 13.3 0.0 20 5.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDF37870.1 - 0.099 12.2 0.0 13 5.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDF37870.1 - 0.11 12.7 0.0 26 5.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 CDF37870.1 - 0.12 11.3 0.0 10 4.9 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain SbcCD_C PF13558.6 CDF37870.1 - 0.4 11.0 8.2 4.2 7.7 0.5 4.5 4 2 0 4 4 3 0 Putative exonuclease SbcCD, C subunit Herpes_UL17 PF04559.12 CDF37870.1 - 0.41 9.4 1.3 5.3 5.7 0.1 2.1 2 0 0 2 2 2 0 Herpesvirus UL17 protein DUF3185 PF11381.8 CDF37870.1 - 0.56 10.3 4.7 2.6 8.1 0.0 4.0 4 0 0 4 4 3 0 Protein of unknown function (DUF3185) CTP_transf_1 PF01148.20 CDF37872.1 - 1.5e-60 205.2 10.3 1.9e-60 204.9 10.3 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family DUF1658 PF07871.11 CDF37877.1 - 1.2 9.2 4.5 7.6 6.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) G6PD_C PF02781.16 CDF37879.1 - 1.2e-108 362.8 0.0 1.6e-108 362.3 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CDF37879.1 - 1.8e-55 188.3 0.0 2.6e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF1548 PF07579.11 CDF37879.1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) ArsA_ATPase PF02374.15 CDF37881.1 - 1.9e-129 431.3 0.2 1.8e-69 234.3 0.1 3.1 2 2 0 2 2 2 2 Anion-transporting ATPase CbiA PF01656.23 CDF37881.1 - 2.5e-19 69.6 0.0 2.3e-09 37.4 0.0 2.8 2 1 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDF37881.1 - 7.6e-17 61.8 0.0 3.4e-07 30.3 0.0 3.1 2 2 0 2 2 2 2 AAA domain ParA PF10609.9 CDF37881.1 - 9.2e-13 48.2 3.7 1.4e-06 27.9 0.0 4.2 4 0 0 4 4 4 2 NUBPL iron-transfer P-loop NTPase IstB_IS21 PF01695.17 CDF37881.1 - 1.1e-06 28.5 0.2 0.028 14.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein PhoH PF02562.16 CDF37881.1 - 5.8e-06 25.9 0.1 0.02 14.3 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein CBP_BcsQ PF06564.12 CDF37881.1 - 6.7e-06 25.7 0.1 0.0056 16.2 0.0 2.3 2 0 0 2 2 2 2 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 CDF37881.1 - 3.4e-05 23.4 0.1 0.15 11.5 0.0 2.5 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MeaB PF03308.16 CDF37881.1 - 4.8e-05 22.5 1.5 0.07 12.1 0.0 2.8 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 CDF37881.1 - 0.00021 21.7 4.9 0.088 13.2 0.1 3.2 3 2 0 3 3 2 2 AAA ATPase domain Zeta_toxin PF06414.12 CDF37881.1 - 0.00027 20.3 0.2 0.57 9.4 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin NB-ARC PF00931.22 CDF37881.1 - 0.00032 20.0 0.2 0.25 10.5 0.1 2.4 2 0 0 2 2 2 2 NB-ARC domain Tir_receptor_N PF07490.11 CDF37881.1 - 0.00088 19.2 0.4 0.52 10.1 0.1 2.3 2 0 0 2 2 2 2 Translocated intimin receptor (Tir) N-terminus AAA_24 PF13479.6 CDF37881.1 - 0.0011 18.8 0.1 0.4 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 CDF37881.1 - 0.0013 18.4 5.0 0.91 9.1 0.1 3.8 4 0 0 4 4 4 2 SRP54-type protein, GTPase domain APS_kinase PF01583.20 CDF37881.1 - 0.0017 18.2 0.3 0.54 10.1 0.1 2.9 2 0 0 2 2 2 1 Adenylylsulphate kinase DUF815 PF05673.13 CDF37881.1 - 0.0026 17.0 0.0 0.43 9.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PIF1 PF05970.14 CDF37881.1 - 0.011 15.0 0.2 1.1 8.3 0.0 2.5 2 0 0 2 2 2 0 PIF1-like helicase AAA PF00004.29 CDF37881.1 - 0.012 16.0 0.2 3.2 8.2 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CDF37881.1 - 0.02 14.8 0.4 6.9 6.6 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase DUF1635 PF07795.11 CDF37881.1 - 0.03 14.2 1.9 0.059 13.2 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DnaB_C PF03796.15 CDF37881.1 - 0.032 13.6 0.1 8 5.7 0.0 2.5 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain LpxK PF02606.14 CDF37881.1 - 0.05 12.7 3.3 3.5 6.6 0.0 3.0 4 0 0 4 4 4 0 Tetraacyldisaccharide-1-P 4'-kinase AAA_18 PF13238.6 CDF37881.1 - 0.056 14.0 0.4 4.1 7.9 0.2 2.8 2 0 0 2 2 2 0 AAA domain Imm51 PF15595.6 CDF37881.1 - 0.14 12.1 0.9 4.2 7.4 0.0 2.7 3 0 0 3 3 2 0 Immunity protein 51 AAA_25 PF13481.6 CDF37881.1 - 0.32 10.6 9.3 0.32 10.6 0.3 3.2 4 1 0 4 4 4 0 AAA domain NTPase_1 PF03266.15 CDF37881.1 - 0.88 9.5 4.4 49 3.8 0.0 3.4 3 0 0 3 3 3 0 NTPase ATP_bind_1 PF03029.17 CDF37881.1 - 2.5 7.8 6.5 29 4.3 0.2 3.6 4 1 0 4 4 3 0 Conserved hypothetical ATP binding protein Ribosomal_L18p PF00861.22 CDF37882.1 - 5.6e-13 49.3 0.0 1e-12 48.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast HgmA PF04209.13 CDF37883.1 - 1.6e-173 577.3 0.0 2e-173 577.0 0.0 1.1 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase DUF5478 PF17572.2 CDF37883.1 - 0.037 14.1 0.2 0.098 12.8 0.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5478) Ribosomal_L13 PF00572.18 CDF37886.1 - 4.4e-47 159.4 0.0 6e-47 159.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 PRKCSH-like PF12999.7 CDF37888.1 - 9e-34 116.8 2.2 9e-34 116.8 2.2 2.8 3 1 0 3 3 3 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 CDF37888.1 - 5.2e-28 97.7 0.1 5.2e-28 97.7 0.1 2.4 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 CDF37888.1 - 0.00021 22.2 1.0 0.00084 20.3 0.1 2.5 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein APG6_N PF17675.1 CDF37888.1 - 0.024 15.2 6.4 0.024 15.2 6.4 2.9 3 1 0 3 3 3 0 Apg6 coiled-coil region Mpp10 PF04006.12 CDF37888.1 - 6.3 5.1 39.4 8.4 4.7 39.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Myb_DNA-binding PF00249.31 CDF37889.1 - 1.3e-14 54.1 0.4 1.2e-06 28.6 0.2 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF37889.1 - 6.3e-06 26.3 0.4 0.13 12.5 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF37889.1 - 0.0012 18.7 1.2 0.005 16.7 0.4 2.4 2 0 0 2 2 2 1 Myb DNA-binding like Semialdhyde_dhC PF02774.18 CDF37892.1 - 2.3e-36 125.6 0.0 3.7e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CDF37892.1 - 1.9e-29 102.6 0.0 3.5e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_C PF02800.20 CDF37892.1 - 0.00052 19.7 0.5 0.0072 15.9 0.5 2.2 1 1 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DXP_reductoisom PF02670.16 CDF37892.1 - 0.0013 19.5 0.0 0.0041 17.8 0.0 1.9 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase NAD_binding_10 PF13460.6 CDF37892.1 - 0.013 15.4 0.0 4.5 7.1 0.0 2.4 2 0 0 2 2 2 0 NAD(P)H-binding DapB_N PF01113.20 CDF37892.1 - 0.014 15.5 0.0 0.06 13.5 0.0 2.2 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ERCC4 PF02732.15 CDF37896.1 - 0.0011 19.2 0.0 0.0029 17.8 0.0 1.7 1 1 1 2 2 2 1 ERCC4 domain CDT1_C PF16679.5 CDF37896.1 - 0.048 14.1 3.1 0.13 12.7 3.1 1.7 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain DUF3903 PF13043.6 CDF37896.1 - 0.058 13.2 1.0 0.18 11.6 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3903) Ank_2 PF12796.7 CDF37897.1 - 1.7e-24 86.2 0.0 6.6e-08 33.0 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDF37897.1 - 7.7e-24 83.8 0.3 2.4e-09 37.5 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDF37897.1 - 3.3e-21 73.1 1.6 3e-06 27.1 0.0 6.9 8 0 0 8 8 8 4 Ankyrin repeat DHHC PF01529.20 CDF37897.1 - 1.8e-20 73.4 4.9 1.8e-20 73.4 4.9 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.30 CDF37897.1 - 5.7e-19 67.7 2.3 1.5e-05 25.2 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 CDF37897.1 - 2.3e-17 62.8 2.9 2.2e-05 24.6 0.0 5.1 3 2 2 5 5 5 3 Ankyrin repeats (many copies) zf-H2C2_2 PF13465.6 CDF37898.1 - 1.6e-10 40.9 2.3 1.6e-10 40.9 2.3 2.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 CDF37898.1 - 7e-06 26.2 19.0 1.8e-05 24.9 1.6 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF37898.1 - 0.0033 18.1 11.1 0.041 14.7 1.2 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 CDF37898.1 - 0.063 13.7 5.1 0.35 11.3 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 CDF37898.1 - 0.28 11.5 3.9 0.77 10.1 3.9 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon C1_4 PF07975.12 CDF37898.1 - 0.34 11.2 2.8 1.1 9.5 2.8 1.9 1 0 0 1 1 1 0 TFIIH C1-like domain COX14 PF14880.6 CDF37898.1 - 3.6 7.5 5.2 12 5.8 5.2 1.9 1 0 0 1 1 1 0 Cytochrome oxidase c assembly SBF PF01758.16 CDF37899.1 - 2.6e-35 121.9 20.0 4.8e-35 121.0 20.0 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family Glyco_transf_25 PF01755.17 CDF37901.1 - 1.5e-07 31.5 0.0 2.3e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) ABC_ATPase PF09818.9 CDF37904.1 - 1.9e-170 567.5 0.0 3.1e-170 566.8 0.0 1.3 1 1 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 CDF37904.1 - 0.0078 16.7 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain PAC2 PF09754.9 CDF37904.1 - 0.14 12.1 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 PAC2 family Ribonuc_red_lgC PF02867.15 CDF37905.1 - 1.6e-186 620.9 0.0 3.9e-186 619.6 0.0 1.6 2 0 0 2 2 2 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CDF37905.1 - 1.1e-23 83.0 0.0 2.8e-23 81.7 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CDF37905.1 - 3.7e-18 65.9 0.0 1.1e-17 64.3 0.0 1.9 1 0 0 1 1 1 1 ATP cone domain Gcd10p PF04189.13 CDF37908.1 - 5.5e-52 176.8 0.0 7.1e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family C4bp_oligo PF18453.1 CDF37908.1 - 0.09 13.0 0.2 0.2 11.9 0.2 1.6 1 0 0 1 1 1 0 Oligomerization domain of C4b-binding protein alpha RRM_1 PF00076.22 CDF37909.1 - 3e-71 235.2 3.6 4.5e-17 61.6 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDF37909.1 - 1.7e-06 27.6 0.0 0.035 13.7 0.0 4.1 4 1 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF37909.1 - 0.00075 19.3 0.0 1.4 8.8 0.0 3.4 3 0 0 3 3 3 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 CDF37909.1 - 0.022 15.0 4.3 1.3 9.2 0.6 4.5 3 2 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Presenilin PF01080.17 CDF37909.1 - 3.4 6.3 9.2 11 4.6 9.2 1.8 1 0 0 1 1 1 0 Presenilin UPF0176_N PF17773.1 CDF37910.1 - 2.2e-18 66.4 0.0 3.6e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 CDF37910.1 - 3.9e-09 36.8 8.6 7e-09 35.9 8.6 1.4 1 0 0 1 1 1 1 Rhodanase C-terminal Rhodanese PF00581.20 CDF37910.1 - 2.4e-07 31.2 0.0 4.4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Ribosomal_S8e PF01201.22 CDF37911.1 - 2.1e-49 167.2 7.0 5.2e-49 165.9 7.0 1.6 1 1 0 1 1 1 1 Ribosomal protein S8e HPD PF05044.12 CDF37911.1 - 0.31 10.9 2.7 7.9 6.3 0.6 2.3 1 1 1 2 2 2 0 Homeo-prospero domain NTP_transf_3 PF12804.7 CDF37915.1 - 2.4e-14 54.0 0.0 5e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDF37915.1 - 2.2e-08 34.0 0.0 6.2e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase GHMP_kinases_N PF00288.26 CDF37915.1 - 1.1e-06 28.8 0.0 2.7e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain IspD PF01128.19 CDF37915.1 - 0.00072 19.4 0.0 0.003 17.3 0.0 2.0 1 1 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GHMP_kinases_C PF08544.13 CDF37915.1 - 0.00073 19.8 0.1 0.0024 18.2 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal CTP_transf_3 PF02348.19 CDF37915.1 - 0.23 11.3 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase V-ATPase_C PF03223.15 CDF37917.1 - 8.6e-108 361.0 0.1 9.7e-108 360.9 0.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C CMD PF02627.20 CDF37922.1 - 5.6 7.1 8.3 0.56 10.3 0.1 2.7 3 0 0 3 3 3 0 Carboxymuconolactone decarboxylase family bZIP_2 PF07716.15 CDF37926.1 - 0.0014 18.7 12.0 0.0014 18.7 12.0 2.1 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CDF37926.1 - 0.85 9.8 17.2 4 7.6 17.2 2.0 1 1 0 1 1 1 0 bZIP transcription factor bZIP_1 PF00170.21 CDF37928.1 - 0.014 15.5 16.0 0.024 14.7 16.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 CDF37928.1 - 0.064 13.3 16.0 0.029 14.4 12.6 2.0 1 1 1 2 2 2 0 Basic region leucine zipper Tom5 PF10642.9 CDF37929.1 - 0.076 13.0 2.5 0.82 9.7 2.5 2.0 1 1 0 1 1 1 0 Mitochondrial import receptor subunit or translocase tRNA_lig_CPD PF08302.11 CDF37930.1 - 0.043 13.3 0.0 0.053 13.0 0.0 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain tRNA-synt_2 PF00152.20 CDF37932.1 - 8.8e-81 271.4 0.1 1.1e-80 271.1 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDF37932.1 - 7.5e-10 38.7 0.0 1.7e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDF37932.1 - 4e-08 33.0 0.1 0.00014 21.4 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) Gag_p12 PF01141.18 CDF37934.1 - 0.015 15.6 1.3 0.025 14.9 0.0 2.0 2 1 0 2 2 2 0 Gag polyprotein, inner coat protein p12 RT_RNaseH PF17917.1 CDF37935.1 - 6.2e-34 116.4 0.0 2.6e-33 114.5 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF37935.1 - 3.6e-32 110.4 0.0 7.2e-32 109.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF37935.1 - 5e-18 65.4 0.0 1.3e-17 64.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF37935.1 - 2.3e-16 59.6 0.2 6.5e-16 58.2 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF37935.1 - 1.8e-08 34.2 0.0 4.6e-06 26.3 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF37935.1 - 0.0018 18.5 0.0 0.0039 17.4 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 CDF37935.1 - 0.11 12.2 0.0 0.5 10.2 0.0 2.2 1 0 0 1 1 1 0 Integrase core domain FGAR-AT_linker PF18072.1 CDF37935.1 - 0.19 12.3 0.0 4.8 7.8 0.0 2.9 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain Sel1 PF08238.12 CDF37936.1 - 3.4e-41 138.8 7.5 1.2e-05 25.8 0.0 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.6 CDF37936.1 - 1.1e-10 41.4 13.6 2.2 9.1 0.0 8.3 7 2 1 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37936.1 - 3e-10 40.6 24.9 0.029 15.0 0.5 5.8 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 CDF37936.1 - 3.3e-06 26.7 12.9 1.6 9.0 0.1 7.1 6 1 1 7 7 7 2 Tetratricopeptide repeat MIT PF04212.18 CDF37936.1 - 0.0002 21.4 3.6 6.6 6.9 0.0 5.4 6 0 0 6 6 6 1 MIT (microtubule interacting and transport) domain NSF PF02071.20 CDF37936.1 - 0.00043 20.5 4.0 1.7e+02 3.8 0.0 6.7 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat TPR_14 PF13428.6 CDF37936.1 - 0.00092 19.8 23.1 10 7.2 0.0 7.7 5 3 3 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF37936.1 - 0.11 12.7 17.8 22 5.5 0.1 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat SSPI PF14098.6 CDF37936.1 - 0.18 12.0 0.2 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Small, acid-soluble spore protein I TPR_1 PF00515.28 CDF37936.1 - 2.4 8.1 11.8 21 5.1 0.1 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat Sel1 PF08238.12 CDF37937.1 - 9.5e-75 245.4 21.7 6.7e-07 29.8 0.0 13.1 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.6 CDF37937.1 - 2.3e-24 84.4 25.9 0.059 14.0 0.0 13.9 13 1 0 13 13 13 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDF37937.1 - 6e-17 62.0 34.3 0.012 16.3 0.1 10.8 4 4 4 10 10 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37937.1 - 8.3e-14 50.9 0.1 2.5 8.7 0.0 11.3 10 4 1 11 11 11 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF37937.1 - 9.4e-10 37.8 33.9 5.9 7.2 0.0 12.6 10 4 3 13 13 13 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF37937.1 - 1.9e-09 37.5 39.3 7.8 7.6 1.0 12.8 8 3 5 13 13 13 1 Tetratricopeptide repeat MIT PF04212.18 CDF37937.1 - 1.5e-06 28.2 13.9 22 5.2 0.0 9.5 11 0 0 11 11 11 0 MIT (microtubule interacting and transport) domain NSF PF02071.20 CDF37937.1 - 0.00024 21.2 17.3 85 4.7 0.1 10.9 12 0 0 12 12 11 0 Aromatic-di-Alanine (AdAR) repeat ComR_TPR PF18710.1 CDF37937.1 - 0.0004 20.0 0.0 7.8 6.0 0.0 4.8 5 0 0 5 5 5 1 ComR tetratricopeptide TPR_2 PF07719.17 CDF37937.1 - 0.0011 19.0 34.2 33 4.9 0.0 12.3 13 0 0 13 13 12 0 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF37937.1 - 0.0015 18.7 6.4 7.4 6.9 0.0 6.2 3 2 4 7 7 7 1 Arginine decarboxylase helical bundle domain Exonuc_VII_S PF02609.16 CDF37937.1 - 0.0017 18.3 9.2 6.7 6.9 0.0 7.8 10 0 0 10 10 10 1 Exonuclease VII small subunit FlaC_arch PF05377.11 CDF37937.1 - 0.0028 18.0 0.0 90 3.6 0.0 5.6 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) DUF268 PF03269.14 CDF37937.1 - 0.0032 17.3 0.4 1.5 8.7 0.0 3.5 3 1 0 3 3 3 1 Caenorhabditis protein of unknown function, DUF268 TPR_1 PF00515.28 CDF37937.1 - 0.0034 17.1 21.7 25 4.9 0.0 9.6 11 0 0 11 11 10 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDF37937.1 - 0.009 15.7 11.4 50 3.7 0.0 7.6 8 0 0 8 8 8 0 TPR repeat GP57 PF17594.2 CDF37937.1 - 0.02 14.6 0.6 5.4 6.8 0.0 3.9 4 0 0 4 4 4 0 Phage Tail fiber assembly helper gene product 57 PHA_gran_rgn PF09650.10 CDF37937.1 - 0.054 13.8 0.3 1e+02 3.3 0.0 4.7 5 0 0 5 5 5 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) JMY PF15871.5 CDF37937.1 - 0.087 12.1 0.8 31 3.7 0.0 3.8 3 1 1 4 4 4 0 Junction-mediating and -regulatory protein HEPN_Apea PF18739.1 CDF37937.1 - 0.13 12.7 0.5 6.3e+02 0.9 0.0 5.9 9 2 1 10 10 8 0 Apea-like HEPN PAP2 PF01569.21 CDF37939.1 - 0.072 12.9 0.4 0.6 9.9 0.4 2.1 1 1 0 1 1 1 0 PAP2 superfamily HalOD1 PF18545.1 CDF37939.1 - 0.087 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Halobacterial output domain 1 VF530 PF09905.9 CDF37939.1 - 0.17 12.1 0.1 0.77 10.0 0.0 2.0 2 0 0 2 2 2 0 DNA-binding protein VF530 DUF4094 PF13334.6 CDF37940.1 - 0.059 13.8 3.0 0.76 10.2 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) SBP_bac_3 PF00497.20 CDF37940.1 - 0.086 12.2 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 DUF2964 PF11177.8 CDF37940.1 - 1.2 9.4 4.0 3.4 7.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2964) AAA_2 PF07724.14 CDF37942.1 - 2.5e-37 128.6 0.0 4.2e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 CDF37942.1 - 5.8e-13 48.7 0.1 1.2e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDF37942.1 - 2.1e-12 47.6 0.0 4.5e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDF37942.1 - 4.8e-07 29.9 0.0 1.7e-06 28.1 0.0 1.9 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CDF37942.1 - 4.6e-06 25.9 0.1 8.4e-06 25.0 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain RuvB_N PF05496.12 CDF37942.1 - 6e-05 22.8 0.7 0.0051 16.6 0.1 3.5 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF37942.1 - 0.00018 21.8 0.0 0.00062 20.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF37942.1 - 0.00034 21.0 0.6 0.0015 18.9 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 CDF37942.1 - 0.0004 20.2 0.0 0.00092 19.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDF37942.1 - 0.00073 19.0 0.1 0.55 9.6 0.0 3.1 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDF37942.1 - 0.00097 18.9 0.0 0.019 14.7 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain Bac_DnaA PF00308.18 CDF37942.1 - 0.0032 17.3 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein AAA_24 PF13479.6 CDF37942.1 - 0.0076 16.0 0.1 0.016 14.9 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF37942.1 - 0.0087 16.6 0.0 0.019 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDF37942.1 - 0.011 15.3 0.1 0.033 13.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 CDF37942.1 - 0.012 14.5 0.0 0.027 13.4 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 CDF37942.1 - 0.016 15.2 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDF37942.1 - 0.018 15.4 0.0 0.051 14.0 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_14 PF13173.6 CDF37942.1 - 0.031 14.3 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 CDF37942.1 - 0.032 14.3 0.1 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_28 PF13521.6 CDF37942.1 - 0.038 14.2 1.2 0.5 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDF37942.1 - 0.051 13.5 0.0 0.24 11.3 0.0 2.2 3 0 0 3 3 2 0 NACHT domain PduV-EutP PF10662.9 CDF37942.1 - 0.16 11.7 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RWP-RK PF02042.15 CDF37947.1 - 1.5e-21 76.1 0.2 2.5e-21 75.4 0.2 1.4 1 0 0 1 1 1 1 RWP-RK domain AMH_N PF04709.12 CDF37948.1 - 0.2 10.5 0.3 0.27 10.1 0.3 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region DDE_1 PF03184.19 CDF37950.1 - 3.8e-10 39.7 0.0 5.7e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease RRM_1 PF00076.22 CDF37952.1 - 7.7e-13 48.1 0.0 1.4e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 CDF37952.1 - 1.3e-05 25.8 0.0 2.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH_3 PF15663.5 CDF37952.1 - 0.0022 18.2 0.3 0.0048 17.1 0.3 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH PF00642.24 CDF37952.1 - 0.0028 17.5 2.6 0.0028 17.5 2.6 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDF37952.1 - 0.0035 17.4 3.4 0.0035 17.4 3.4 1.9 2 0 0 2 2 2 1 Zinc finger domain Limkain-b1 PF11608.8 CDF37952.1 - 0.16 12.1 0.2 0.37 10.9 0.2 1.5 1 0 0 1 1 1 0 Limkain b1 zf-CCCH_4 PF18044.1 CDF37952.1 - 0.19 11.6 3.1 0.44 10.4 3.1 1.7 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDF37952.1 - 0.76 10.3 2.8 1.8 9.1 2.8 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Ribosomal_L15e PF00827.17 CDF37953.1 - 4.1e-91 303.9 8.2 4.8e-91 303.7 8.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 Pkinase PF00069.25 CDF37954.1 - 2e-25 89.7 0.0 2.4e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Peptidase_C97 PF05903.14 CDF37954.1 - 1.4e-16 60.7 0.0 2e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain Pkinase_Tyr PF07714.17 CDF37954.1 - 4.7e-08 32.6 0.0 6.2e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 CDF37954.1 - 0.054 13.1 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Sel1 PF08238.12 CDF37955.1 - 1.1e-113 369.0 24.8 1.3e-07 32.1 0.2 16.7 17 0 0 17 17 17 15 Sel1 repeat TPR_6 PF13174.6 CDF37955.1 - 4.6e-17 61.4 0.5 1.8 9.3 0.0 11.0 13 1 0 13 13 13 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDF37955.1 - 9.6e-11 41.3 0.0 1.1e+02 3.6 0.0 12.6 16 0 0 16 16 16 0 Tetratricopeptide repeat ATP-synt_DE PF00401.20 CDF37955.1 - 0.00026 21.2 0.4 1.7e+02 2.6 0.0 6.5 6 0 0 6 6 6 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain PPR_long PF17177.4 CDF37955.1 - 0.0032 16.9 9.6 49 3.2 0.0 8.8 9 5 3 12 12 12 0 Pentacotripeptide-repeat region of PRORP DMA PF03474.14 CDF37955.1 - 1.5 8.4 6.5 2.1e+02 1.6 0.1 5.5 4 0 0 4 4 4 0 DMRTA motif HTH_Tnp_Tc3_1 PF11427.8 CDF37959.1 - 2.7e-09 36.7 0.0 4.4e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF37959.1 - 2.1e-06 27.4 0.0 7.2e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF37959.1 - 2.7e-06 27.0 0.0 1.1e-05 25.1 0.0 1.9 2 1 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CDF37959.1 - 0.012 15.3 0.0 0.41 10.3 0.0 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.6 CDF37959.1 - 0.017 14.7 0.1 0.047 13.3 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.12 CDF37959.1 - 0.033 13.8 0.0 0.071 12.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_29 PF13551.6 CDF37959.1 - 0.038 14.0 0.2 0.083 12.9 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn helix HTH_11 PF08279.12 CDF37959.1 - 0.041 13.8 0.2 0.78 9.7 0.0 2.7 4 0 0 4 4 4 0 HTH domain DDE_3 PF13358.6 CDF37960.1 - 4.9e-18 65.3 0.0 1.3e-17 63.9 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease IBR PF01485.21 CDF37961.1 - 0.069 13.4 4.1 0.2 11.9 4.1 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CEBP_ZZ PF16366.5 CDF37961.1 - 0.094 13.0 1.7 0.23 11.7 1.7 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain ACBP PF00887.19 CDF37962.1 - 1.5e-06 28.3 0.0 0.0097 16.1 0.0 2.5 2 0 0 2 2 2 2 Acyl CoA binding protein WD40 PF00400.32 CDF37964.1 - 5.8e-18 64.9 6.1 0.01 16.7 0.0 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF37964.1 - 9e-08 32.3 0.0 0.037 14.3 0.0 4.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3477 PF11963.8 CDF37964.1 - 0.0085 15.3 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3477) zf-MYND PF01753.18 CDF37965.1 - 2e-09 37.4 8.6 3.2e-09 36.7 8.6 1.3 1 0 0 1 1 1 1 MYND finger PD40 PF07676.12 CDF37966.1 - 0.0054 16.6 0.1 0.33 11.0 0.0 3.0 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Amidinotransf PF02274.17 CDF37967.1 - 2.4e-48 165.0 0.0 4.6e-48 164.0 0.0 1.5 1 1 0 1 1 1 1 Amidinotransferase Ribosomal_S3_C PF00189.20 CDF37968.1 - 4e-24 84.9 0.7 1.4e-23 83.2 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CDF37968.1 - 1e-13 50.9 0.3 1.6e-13 50.3 0.3 1.3 1 0 0 1 1 1 1 KH domain DUF1908 PF08926.11 CDF37969.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) WD40 PF00400.32 CDF37970.1 - 1.6e-15 57.2 16.5 0.00017 22.3 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CDF37970.1 - 0.00012 22.3 0.0 0.00088 19.5 0.0 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ATP_bind_3 PF01171.20 CDF37970.1 - 0.19 11.5 0.0 44 3.8 0.0 3.0 3 0 0 3 3 3 0 PP-loop family PDDEXK_1 PF12705.7 CDF37971.1 - 2.4e-06 27.7 0.0 3.1e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Glyco_hydro_6 PF01341.17 CDF37972.1 - 7.8e-47 160.5 0.0 9.7e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 WD40 PF00400.32 CDF37975.1 - 0.00018 22.2 4.8 0.83 10.6 0.1 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat MAPEG PF01124.18 CDF37976.1 - 8.9e-18 64.4 2.0 1.1e-17 64.2 2.0 1.1 1 0 0 1 1 1 1 MAPEG family Tad PF13400.6 CDF37976.1 - 3.9 7.8 7.2 20 5.6 2.6 2.4 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Pkinase PF00069.25 CDF37978.1 - 7e-63 212.5 0.0 1.2e-62 211.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF37978.1 - 6e-31 107.7 0.0 9.1e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 CDF37978.1 - 3e-08 34.0 0.7 0.041 14.3 0.1 4.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 CDF37978.1 - 7.2e-07 28.3 0.4 0.12 12.0 0.1 4.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 CDF37978.1 - 1.2e-06 27.9 0.7 0.33 11.0 0.0 4.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 CDF37978.1 - 0.00031 20.5 0.4 0.4 10.6 0.0 3.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 CDF37978.1 - 0.002 17.5 0.1 0.039 13.5 0.0 2.9 3 0 0 3 3 3 1 EF hand APH PF01636.23 CDF37978.1 - 0.0029 17.6 0.0 0.0064 16.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family TGFb_propeptide PF00688.18 CDF37978.1 - 0.0061 16.3 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 TGF-beta propeptide Haspin_kinase PF12330.8 CDF37978.1 - 0.019 13.9 0.0 0.045 12.7 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 CDF37978.1 - 0.18 11.1 0.0 0.48 9.7 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Hint PF01079.20 CDF37979.1 - 7.4e-24 84.4 0.0 1.5e-23 83.4 0.0 1.5 1 1 0 1 1 1 1 Hint module Pentapeptide_3 PF13576.6 CDF37979.1 - 0.0011 19.0 2.7 1.3 9.2 0.8 3.1 2 1 0 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 CDF37979.1 - 0.0028 17.8 2.2 0.41 10.9 0.1 2.8 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Hint_2 PF13403.6 CDF37979.1 - 0.0057 17.0 0.0 0.03 14.6 0.0 2.1 1 1 0 1 1 1 1 Hint domain Sec23_trunk PF04811.15 CDF37980.1 - 5.5e-53 180.0 0.0 7.3e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDF37980.1 - 5.7e-17 62.2 0.0 1.2e-16 61.2 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CDF37980.1 - 1.6e-15 56.8 0.1 3.4e-15 55.7 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDF37980.1 - 4.1e-14 52.3 4.7 1.1e-13 51.0 4.7 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 CDF37980.1 - 0.044 13.2 0.0 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Cyt-b5 PF00173.28 CDF37981.1 - 1.8e-06 28.0 0.2 3.2e-06 27.2 0.2 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TMEM100 PF16311.5 CDF37981.1 - 0.05 13.2 0.1 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Transmembrane protein 100 SEEK1 PF15357.6 CDF37983.1 - 3.6 7.7 11.0 2.2 8.4 9.1 1.6 1 1 1 2 2 2 0 Psoriasis susceptibility 1 candidate 1 SURF4 PF02077.15 CDF37984.1 - 1.5e-51 175.5 7.7 2e-51 175.2 7.7 1.0 1 0 0 1 1 1 1 SURF4 family DUF3767 PF12597.8 CDF37984.1 - 0.013 15.3 0.8 0.078 12.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) FixQ PF05545.11 CDF37984.1 - 0.2 11.7 8.0 0.26 11.3 1.6 2.8 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ FR47 PF08445.10 CDF37985.1 - 9.6e-11 41.5 0.0 5.2e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_1 PF00583.25 CDF37985.1 - 1e-08 35.4 0.0 1.1e-07 32.1 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF37985.1 - 2e-08 34.2 0.0 2.8e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF37985.1 - 4.5e-07 30.2 0.0 3.8e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 CDF37985.1 - 0.00012 21.9 0.0 0.028 14.2 0.0 3.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDF37985.1 - 0.00034 20.7 0.0 0.00093 19.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDF37985.1 - 0.0022 18.7 0.0 2.9 8.6 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FTP PF07504.13 CDF37985.1 - 0.026 14.4 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 Fungalysin/Thermolysin Propeptide Motif Acetyltransf_4 PF13420.7 CDF37985.1 - 0.094 12.8 0.0 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain rve PF00665.26 CDF37987.1 - 1.2e-09 38.3 0.0 2.9e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CDF37987.1 - 3e-07 30.3 0.0 5.1e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CDF37987.1 - 0.013 15.3 0.6 0.038 13.8 0.6 1.8 1 0 0 1 1 1 0 GAG-pre-integrase domain Integrase_H2C2 PF17921.1 CDF37987.1 - 0.037 14.1 0.0 0.097 12.8 0.0 1.8 1 0 0 1 1 1 0 Integrase zinc binding domain FAM25 PF15825.5 CDF37987.1 - 0.15 12.4 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 FAM25 family RVT_1 PF00078.27 CDF37989.1 - 6.4e-24 84.7 0.0 1.1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 CDF37989.1 - 5.7e-09 35.8 0.0 9.2e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 CDF37989.1 - 0.00017 22.1 0.0 0.0011 19.5 0.0 2.4 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDF37989.1 - 0.00074 20.1 0.0 0.0066 17.1 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease Retrotrans_gag PF03732.17 CDF37989.1 - 0.015 15.6 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein Integrase_H2C2 PF17921.1 CDF37990.1 - 1.6e-15 56.9 0.2 3.3e-15 55.9 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF37990.1 - 4.6e-06 26.8 0.1 1.1e-05 25.5 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDF37990.1 - 0.0033 17.6 0.0 0.0085 16.3 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger DDE_Tnp_IS66 PF03050.14 CDF37990.1 - 0.12 11.8 0.2 16 4.9 0.0 2.3 2 0 0 2 2 2 0 Transposase IS66 family DUF3099 PF11298.8 CDF37991.1 - 0.07 13.3 0.0 0.079 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) Toxin_14 PF07829.11 CDF37993.1 - 0.6 10.1 10.5 2.3 8.3 3.4 3.2 3 0 0 3 3 3 0 Alpha-A conotoxin PIVA-like protein Hydrolase PF00702.26 CDF37994.1 - 3e-08 34.2 0.8 2.9e-07 31.0 0.3 2.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDF37994.1 - 1e-07 31.9 0.0 3.5e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) HTH_48 PF17906.1 CDF37994.1 - 0.056 13.6 0.2 5.6 7.2 0.3 3.2 3 0 0 3 3 3 0 HTH domain in Mos1 transposase Myb_DNA-binding PF00249.31 CDF37997.1 - 2.2e-10 40.6 0.1 3.7e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF37997.1 - 0.028 14.7 0.1 0.068 13.4 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF37997.1 - 0.055 13.4 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 Myb DNA-binding like FHA PF00498.26 CDF37998.1 - 1.4e-05 25.4 0.0 2.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain FYRC PF05965.14 CDF37998.1 - 0.013 15.7 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 F/Y rich C-terminus FYRN PF05964.14 CDF37998.1 - 0.021 14.7 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 F/Y-rich N-terminus OmpH PF03938.14 CDF37998.1 - 1.7 9.0 8.0 2 8.8 4.3 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) CMAS PF02353.20 CDF37999.1 - 1.2e-78 264.1 0.0 1.5e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CDF37999.1 - 2.4e-14 53.8 0.5 1e-13 51.8 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF37999.1 - 2.9e-11 43.9 0.2 9.3e-11 42.2 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF37999.1 - 6.9e-11 42.2 0.0 1.1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF37999.1 - 4.2e-09 36.4 0.0 6.6e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF37999.1 - 8.5e-07 29.7 0.0 1.7e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF37999.1 - 9.3e-05 22.0 0.0 0.00017 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 CDF37999.1 - 0.0016 18.4 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDF37999.1 - 0.002 18.1 0.1 0.0035 17.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CDF37999.1 - 0.0043 16.6 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 CDF37999.1 - 0.0051 16.3 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CDF37999.1 - 0.0078 15.6 0.1 0.017 14.4 0.1 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 CDF37999.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DOT1 PF08123.13 CDF37999.1 - 0.019 14.5 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 DUF938 PF06080.12 CDF37999.1 - 0.023 14.5 0.0 0.15 11.8 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF938) GARS_C PF02843.16 CDF37999.1 - 0.057 13.7 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, C domain PCMT PF01135.19 CDF37999.1 - 0.083 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ADH_zinc_N PF00107.26 CDF37999.1 - 0.12 12.4 0.1 0.28 11.1 0.1 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RT_RNaseH PF17917.1 CDF38001.1 - 1e-33 115.8 0.0 1.9e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38001.1 - 2.1e-31 107.9 0.0 3.5e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF38001.1 - 2.1e-08 34.1 0.3 4.5e-08 33.1 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF38001.1 - 0.012 15.8 0.0 0.034 14.3 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH PF17917.1 CDF38002.1 - 1.9e-23 82.7 0.0 4.1e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF38002.1 - 3.4e-17 62.7 0.0 9.4e-17 61.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDF38002.1 - 1.5e-14 53.9 0.0 2.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF38002.1 - 1.4e-12 47.5 0.0 1.5e-11 44.2 0.1 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF38002.1 - 0.0027 17.2 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF38002.1 - 0.016 14.9 0.1 0.1 12.4 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain PseudoU_synth_2 PF00849.22 CDF38005.1 - 5.5e-12 46.1 0.0 1.2e-11 44.9 0.0 1.6 1 1 0 1 1 1 1 RNA pseudouridylate synthase CarbpepA_inh PF02977.15 CDF38008.1 - 0.17 11.7 0.2 0.17 11.7 0.2 5.6 4 2 1 5 5 5 0 Carboxypeptidase A inhibitor Mnd1 PF03962.15 CDF38011.1 - 1.2e-26 92.7 0.2 3.1e-26 91.4 0.2 1.7 1 0 0 1 1 1 1 Mnd1 HTH domain LZ3wCH PF18517.1 CDF38011.1 - 2e-19 69.4 1.0 2e-19 69.4 1.0 1.9 2 0 0 2 2 2 1 Leucine zipper with capping helix domain FUR PF01475.19 CDF38011.1 - 0.069 13.3 0.2 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 Ferric uptake regulator family GPW_gp25 PF04965.14 CDF38011.1 - 0.094 12.5 0.7 0.2 11.4 0.6 1.6 1 1 0 1 1 1 0 Gene 25-like lysozyme T3SS_needle_E PF08988.10 CDF38011.1 - 0.1 12.8 2.7 18 5.5 1.7 2.8 2 1 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle 2OG-FeII_Oxy_2 PF13532.6 CDF38012.1 - 2.4e-29 102.9 0.0 2.9e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 CDF38012.1 - 0.11 13.0 0.0 0.27 11.8 0.0 1.7 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Zip PF02535.22 CDF38013.1 - 1.3e-32 113.3 20.1 1.5e-27 96.7 7.2 2.6 1 1 2 3 3 3 3 ZIP Zinc transporter Bax1-I PF01027.20 CDF38013.1 - 0.16 11.7 16.0 0.079 12.8 1.5 2.8 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DctQ PF04290.12 CDF38013.1 - 0.35 10.8 9.8 0.49 10.3 0.5 2.9 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component SLATT_1 PF18181.1 CDF38013.1 - 0.36 10.8 0.0 0.36 10.8 0.0 2.2 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 YqhR PF11085.8 CDF38013.1 - 0.57 10.1 6.0 0.1 12.5 1.7 2.0 2 0 0 2 2 2 0 Conserved membrane protein YqhR DUF996 PF06195.13 CDF38013.1 - 3.7 7.8 13.1 0.99 9.7 2.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF996) E1-E2_ATPase PF00122.20 CDF38013.1 - 5 6.6 6.3 2 7.9 0.3 2.8 3 1 1 4 4 4 0 E1-E2 ATPase TLD PF07534.16 CDF38015.1 - 6.3e-36 123.6 0.0 8.8e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 TLD WD40 PF00400.32 CDF38017.1 - 1.8e-10 41.2 11.3 0.02 15.7 0.0 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat PQQ_3 PF13570.6 CDF38017.1 - 0.00096 19.6 5.9 0.32 11.5 0.2 4.7 4 0 0 4 4 4 1 PQQ-like domain Nucleoporin_N PF08801.11 CDF38017.1 - 0.095 11.4 0.0 0.65 8.7 0.0 2.2 2 1 1 3 3 3 0 Nup133 N terminal like PMT PF02366.18 CDF38018.1 - 2e-43 148.7 10.5 2e-43 148.7 10.5 2.3 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CDF38018.1 - 2e-37 128.7 21.2 4.9e-37 127.5 21.2 1.7 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase DPM2 PF07297.12 CDF38018.1 - 0.015 15.6 0.2 0.015 15.6 0.2 3.4 2 1 1 3 3 3 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Adeno_E3_CR2 PF02439.15 CDF38018.1 - 4.5 7.1 7.9 11 5.8 1.0 2.7 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 ADIP PF11559.8 CDF38019.1 - 0.00016 21.8 5.0 0.00028 21.0 5.0 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CENP-Q PF13094.6 CDF38019.1 - 0.0041 17.3 6.7 0.008 16.4 6.7 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit BRE1 PF08647.11 CDF38019.1 - 0.008 16.2 5.9 0.31 11.1 1.7 2.3 1 1 1 2 2 2 2 BRE1 E3 ubiquitin ligase DUF4472 PF14739.6 CDF38019.1 - 0.01 16.5 5.8 0.022 15.5 4.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 CDF38019.1 - 0.014 15.9 2.8 0.033 14.7 2.8 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Nitrophorin PF02087.15 CDF38019.1 - 0.031 14.3 0.2 0.057 13.4 0.2 1.3 1 0 0 1 1 1 0 Nitrophorin GAS PF13851.6 CDF38019.1 - 0.042 13.2 5.4 0.076 12.4 5.4 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Jnk-SapK_ap_N PF09744.9 CDF38019.1 - 0.042 14.1 6.6 0.087 13.0 6.6 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 SlyX PF04102.12 CDF38019.1 - 0.059 14.0 3.4 0.2 12.3 0.9 2.8 1 1 0 2 2 2 0 SlyX Fez1 PF06818.15 CDF38019.1 - 0.12 12.8 7.1 0.18 12.2 7.1 1.3 1 0 0 1 1 1 0 Fez1 V_ATPase_I PF01496.19 CDF38019.1 - 0.16 9.9 6.8 0.21 9.5 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.8 CDF38019.1 - 0.24 10.7 4.9 0.31 10.3 3.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 CDF38019.1 - 0.28 10.0 5.4 0.4 9.5 5.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.14 CDF38019.1 - 0.28 11.0 3.8 0.48 10.2 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF641 PF04859.12 CDF38019.1 - 1.2 9.4 6.4 4.7 7.6 4.0 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) YabA PF06156.13 CDF38019.1 - 7 7.3 7.3 18 6.0 2.1 3.1 1 1 1 2 2 2 0 Initiation control protein YabA IFT20 PF14931.6 CDF38019.1 - 7.4 6.8 9.6 11 6.2 1.1 2.5 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 Methyltransf_23 PF13489.6 CDF38020.1 - 2.2e-21 76.4 0.0 3.2e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF38020.1 - 8.4e-18 64.8 0.0 1.6e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF38020.1 - 2.8e-16 60.0 0.0 5e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF38020.1 - 5.9e-13 48.7 0.0 2.7e-12 46.6 0.0 1.8 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDF38020.1 - 1.4e-12 47.6 0.0 2e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF38020.1 - 8.7e-11 42.4 0.0 1.6e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CDF38020.1 - 0.023 14.3 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.14 CDF38020.1 - 0.079 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 CDF38020.1 - 0.17 11.9 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain LNS2 PF08235.13 CDF38021.1 - 1.6e-88 296.0 0.0 2.4e-88 295.4 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 CDF38021.1 - 1.6e-26 92.2 0.0 3.3e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 CDF38021.1 - 8e-17 61.2 0.0 1.7e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain RPEL PF02755.15 CDF38021.1 - 0.077 12.7 0.6 0.18 11.5 0.6 1.7 1 0 0 1 1 1 0 RPEL repeat PCRF PF03462.18 CDF38022.1 - 6.3e-69 231.7 0.4 1.2e-68 230.8 0.4 1.5 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 CDF38022.1 - 1.9e-38 131.0 0.8 3.7e-38 130.0 0.8 1.5 1 0 0 1 1 1 1 RF-1 domain DUF4635 PF15466.6 CDF38022.1 - 0.046 13.2 1.0 0.046 13.2 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) MerR-DNA-bind PF09278.11 CDF38022.1 - 4.1 8.0 10.2 0.97 10.0 3.3 2.6 2 0 0 2 2 2 0 MerR, DNA binding RIO1 PF01163.22 CDF38023.1 - 2.1e-42 144.9 0.0 4.7e-42 143.7 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 CDF38023.1 - 2.8e-33 114.0 0.4 5.9e-33 112.9 0.4 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 CDF38023.1 - 2.6e-07 30.8 3.3 0.00022 21.2 1.5 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDF38023.1 - 0.00011 21.6 0.7 0.35 10.2 0.1 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family PIP49_C PF12260.8 CDF38023.1 - 0.00016 21.4 0.0 0.00027 20.7 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Pkinase PF00069.25 CDF38023.1 - 0.0018 17.7 0.2 0.004 16.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Choline_kinase PF01633.20 CDF38023.1 - 0.038 13.6 0.1 0.08 12.5 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 CDF38023.1 - 0.088 12.1 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase GGACT PF06094.12 CDF38024.1 - 8.1e-14 52.3 0.1 1.1e-13 51.8 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like FBPase PF00316.20 CDF38025.1 - 8e-37 126.5 0.0 1.1e-36 126.1 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Na_H_Exchanger PF00999.21 CDF38029.1 - 3.2e-44 151.3 43.1 4.2e-44 150.9 43.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4500 PF14937.6 CDF38029.1 - 0.042 13.9 0.2 0.11 12.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) DUF3153 PF11353.8 CDF38029.1 - 0.16 11.6 0.2 0.34 10.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3153) ALMT PF11744.8 CDF38029.1 - 1.6 7.4 3.0 1.8 7.3 0.2 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter Josephin PF02099.17 CDF38030.1 - 1.3e-19 70.9 0.0 7.5e-19 68.4 0.0 1.8 1 1 0 1 1 1 1 Josephin Exo_endo_phos PF03372.23 CDF38031.1 - 3e-25 89.1 0.3 3.6e-25 88.8 0.3 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CDF38031.1 - 0.00072 19.4 0.0 0.0026 17.6 0.0 1.9 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase ATG16 PF08614.11 CDF38033.1 - 0.12 12.6 193.3 0.021 15.1 19.6 11.2 2 2 8 11 11 11 0 Autophagy protein 16 (ATG16) DUF5542 PF17696.1 CDF38033.1 - 2.3 8.4 5.2 0.84 9.8 0.8 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5542) zf-CCHC_5 PF14787.6 CDF38034.1 - 0.036 13.8 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Ribosomal_S15 PF00312.22 CDF38035.1 - 4.2e-30 103.8 0.1 6e-30 103.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 DUF2688 PF10892.8 CDF38035.1 - 0.013 14.9 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) KLRAQ PF10205.9 CDF38035.1 - 0.13 12.5 0.2 0.19 11.9 0.2 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein HTH_5 PF01022.20 CDF38035.1 - 0.2 11.6 0.1 0.51 10.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family PI3_PI4_kinase PF00454.27 CDF38036.1 - 5.1e-33 114.9 0.4 1.4e-30 107.0 0.4 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CDF38036.1 - 4.3e-08 32.8 0.0 1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 CDF38036.1 - 0.016 14.5 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) UFC1 PF08694.11 CDF38038.1 - 3.5e-79 263.8 0.1 4e-79 263.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 CDF38038.1 - 0.0016 18.1 0.2 0.0026 17.4 0.2 1.4 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDF38038.1 - 0.0085 16.4 0.4 0.016 15.5 0.3 1.5 1 1 0 1 1 1 1 RWD domain AAA_5 PF07728.14 CDF38039.1 - 4.1e-94 311.9 0.0 6e-29 100.8 0.0 8.9 7 1 1 8 8 8 7 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDF38039.1 - 4.6e-23 81.5 0.0 3.4e-08 33.4 0.0 7.6 7 2 0 7 7 5 2 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 CDF38039.1 - 3.2e-22 79.4 0.0 4.5e-07 30.4 0.0 5.9 5 0 0 5 5 5 4 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 CDF38039.1 - 6.4e-22 77.8 11.4 1e-10 41.8 0.6 5.1 5 0 0 5 5 4 3 Midasin AAA lid domain AAA_7 PF12775.7 CDF38039.1 - 3.6e-20 72.2 0.1 3e-05 23.6 0.0 5.6 5 0 0 5 5 5 3 P-loop containing dynein motor region AAA_16 PF13191.6 CDF38039.1 - 5.4e-19 69.2 3.4 6.3e-05 23.4 0.2 6.4 5 0 0 5 5 5 3 AAA ATPase domain AAA_6 PF12774.7 CDF38039.1 - 5.2e-15 55.2 0.4 0.033 13.2 0.1 8.1 8 1 0 8 8 8 3 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 CDF38039.1 - 1.3e-14 54.9 0.3 0.00071 20.1 0.0 6.3 6 0 0 6 6 5 2 AAA domain TsaE PF02367.17 CDF38039.1 - 3.5e-13 49.7 1.5 0.022 14.8 0.2 5.5 5 0 0 5 5 5 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 CDF38039.1 - 7.9e-13 48.9 2.9 0.013 15.7 0.0 7.6 7 0 0 7 7 7 2 AAA domain Sigma54_activat PF00158.26 CDF38039.1 - 1.6e-12 47.4 0.0 0.017 14.9 0.0 6.0 6 0 0 6 6 6 2 Sigma-54 interaction domain AAA_lid_5 PF17865.1 CDF38039.1 - 3.4e-11 43.2 0.0 1.1e-10 41.5 0.0 2.0 1 0 0 1 1 1 1 Midasin AAA lid domain Dynein_heavy PF03028.15 CDF38039.1 - 1.9e-09 37.7 0.0 0.0019 18.2 0.0 3.9 3 0 0 3 3 3 2 Dynein heavy chain region D6 P-loop domain AAA_30 PF13604.6 CDF38039.1 - 6.8e-09 35.7 3.1 0.19 11.4 0.6 6.0 5 1 0 5 5 5 2 AAA domain DUF815 PF05673.13 CDF38039.1 - 2.7e-08 33.3 0.5 0.11 11.6 0.0 4.8 5 0 0 5 5 5 2 Protein of unknown function (DUF815) NACHT PF05729.12 CDF38039.1 - 1.1e-07 31.9 2.0 0.14 12.1 0.0 5.1 5 0 0 5 5 5 2 NACHT domain AAA_14 PF13173.6 CDF38039.1 - 1.2e-07 31.9 0.0 0.12 12.5 0.0 6.2 6 0 0 6 6 6 1 AAA domain ABC_tran PF00005.27 CDF38039.1 - 1.7e-07 31.8 9.1 3.4 8.2 0.0 6.1 6 0 0 6 6 5 1 ABC transporter RNA_helicase PF00910.22 CDF38039.1 - 3.8e-07 30.5 0.7 3 8.3 0.0 6.1 6 0 0 6 6 5 1 RNA helicase AAA_33 PF13671.6 CDF38039.1 - 9.2e-07 29.1 2.0 0.087 13.0 0.0 5.1 5 0 0 5 5 5 1 AAA domain Rad17 PF03215.15 CDF38039.1 - 1.4e-06 28.4 1.3 0.095 12.6 0.0 4.7 5 0 0 5 5 5 2 Rad17 P-loop domain Zeta_toxin PF06414.12 CDF38039.1 - 1.5e-06 27.6 0.9 5.2 6.3 0.1 5.4 5 0 0 5 5 5 0 Zeta toxin RuvB_N PF05496.12 CDF38039.1 - 2.3e-06 27.5 4.4 3.2 7.5 0.0 5.7 5 1 0 5 5 5 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 CDF38039.1 - 4.5e-06 26.6 0.0 0.52 10.0 0.0 4.5 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase RsgA_GTPase PF03193.16 CDF38039.1 - 7.2e-06 26.0 0.3 15 5.4 0.0 5.3 5 0 0 5 5 5 0 RsgA GTPase AAA_29 PF13555.6 CDF38039.1 - 1.4e-05 24.8 0.3 0.59 9.9 0.0 4.5 4 0 0 4 4 4 1 P-loop containing region of AAA domain AAA_19 PF13245.6 CDF38039.1 - 2.5e-05 24.7 5.9 0.82 10.0 0.0 5.7 6 0 0 6 6 4 1 AAA domain IstB_IS21 PF01695.17 CDF38039.1 - 3.9e-05 23.5 0.0 0.12 12.1 0.0 4.3 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_28 PF13521.6 CDF38039.1 - 0.00012 22.4 5.0 0.46 10.7 0.0 5.3 5 0 0 5 5 5 1 AAA domain TIP49 PF06068.13 CDF38039.1 - 0.00012 21.4 0.3 3.4 6.8 0.0 3.4 3 0 0 3 3 3 1 TIP49 P-loop domain AAA_8 PF12780.7 CDF38039.1 - 0.00013 21.4 1.0 0.27 10.5 0.1 3.6 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 T2SSE PF00437.20 CDF38039.1 - 0.00022 20.4 0.6 1.8 7.5 0.0 4.4 4 0 0 4 4 4 1 Type II/IV secretion system protein Mg_chelatase PF01078.21 CDF38039.1 - 0.00025 20.5 3.4 2.7 7.3 0.1 5.5 7 0 0 7 7 6 1 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 CDF38039.1 - 0.00027 21.1 0.1 7.2 6.7 0.0 5.1 5 0 0 5 5 5 0 Sigma-54 interaction domain PduV-EutP PF10662.9 CDF38039.1 - 0.00038 20.2 0.0 31 4.3 0.0 5.3 5 0 0 5 5 5 0 Ethanolamine utilisation - propanediol utilisation DAP3 PF10236.9 CDF38039.1 - 0.0015 17.7 0.4 0.031 13.5 0.0 2.7 3 0 0 3 3 2 1 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 CDF38039.1 - 0.0046 16.6 9.4 7 6.2 0.0 6.2 7 0 0 7 7 6 0 AAA domain dNK PF01712.19 CDF38039.1 - 0.0048 16.8 1.2 14 5.5 0.0 3.7 4 0 0 4 4 3 0 Deoxynucleoside kinase KAP_NTPase PF07693.14 CDF38039.1 - 0.0083 15.4 0.0 11 5.2 0.0 3.3 3 0 0 3 3 3 0 KAP family P-loop domain MCM PF00493.23 CDF38039.1 - 0.012 14.7 0.0 17 4.4 0.0 3.3 3 0 0 3 3 3 0 MCM P-loop domain NTPase_1 PF03266.15 CDF38039.1 - 0.018 14.9 3.0 0.27 11.1 0.1 3.7 4 0 0 4 4 3 0 NTPase VWA_2 PF13519.6 CDF38039.1 - 0.018 15.7 0.0 0.086 13.5 0.0 2.3 1 0 0 1 1 1 0 von Willebrand factor type A domain ATPase_2 PF01637.18 CDF38039.1 - 0.023 14.6 0.0 11 5.9 0.0 4.0 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea VWA PF00092.28 CDF38039.1 - 0.12 12.6 0.0 0.38 11.0 0.0 1.9 2 0 0 2 2 1 0 von Willebrand factor type A domain CPT PF07931.12 CDF38039.1 - 0.13 12.1 0.2 45 3.8 0.0 4.5 4 0 0 4 4 4 0 Chloramphenicol phosphotransferase-like protein cobW PF02492.19 CDF38039.1 - 0.2 11.2 1.8 11 5.5 0.0 3.9 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 CDF38039.1 - 0.28 10.9 6.0 0.65 9.7 0.0 3.8 5 0 0 5 5 3 0 Conserved hypothetical ATP binding protein Cytidylate_kin PF02224.18 CDF38039.1 - 0.45 10.2 3.9 11 5.7 0.0 4.1 5 0 0 5 5 3 0 Cytidylate kinase SRP54 PF00448.22 CDF38039.1 - 4.1 7.0 4.4 52 3.4 0.0 3.6 5 0 0 5 5 4 0 SRP54-type protein, GTPase domain WD40 PF00400.32 CDF38040.1 - 8.1e-38 127.8 19.5 4.4e-06 27.3 0.3 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat NB-ARC PF00931.22 CDF38040.1 - 7e-16 58.2 0.1 1.8e-15 56.8 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF38040.1 - 3.6e-08 33.6 3.8 0.54 10.6 0.0 5.7 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF38040.1 - 6.7e-07 28.3 0.8 4.8 5.7 0.0 5.8 6 0 0 6 6 6 2 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF38040.1 - 0.0014 19.0 0.0 0.0049 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain WSC PF01822.19 CDF38040.1 - 0.066 13.4 0.2 0.21 11.8 0.2 1.9 1 0 0 1 1 1 0 WSC domain NACHT PF05729.12 CDF38040.1 - 0.14 12.0 0.0 0.51 10.2 0.0 1.8 2 0 0 2 2 2 0 NACHT domain PQQ_3 PF13570.6 CDF38040.1 - 6.1 7.5 15.1 8.4 7.0 1.2 5.3 1 1 5 6 6 6 0 PQQ-like domain WD40 PF00400.32 CDF38046.1 - 1.7e-41 139.4 21.1 4.4e-08 33.7 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TIR_2 PF13676.6 CDF38046.1 - 6e-17 62.3 0.0 1.9e-16 60.7 0.0 1.9 1 0 0 1 1 1 1 TIR domain NB-ARC PF00931.22 CDF38046.1 - 2.2e-15 56.6 0.0 4.7e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF38046.1 - 7.2e-09 35.8 5.5 0.16 12.3 0.0 5.6 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF38046.1 - 1.6e-08 33.7 2.1 0.27 9.8 0.0 5.8 5 1 1 6 6 6 3 Nucleoporin Nup120/160 TIR PF01582.20 CDF38046.1 - 4.4e-07 29.9 0.0 9.6e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 TIR domain AAA_22 PF13401.6 CDF38046.1 - 0.0029 17.9 0.0 0.0078 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Cytochrom_D1 PF02239.16 CDF38046.1 - 0.099 11.2 10.7 0.086 11.3 1.8 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain WSC PF01822.19 CDF38046.1 - 0.11 12.7 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 WSC domain PQQ_3 PF13570.6 CDF38046.1 - 0.26 11.8 13.6 8.4 7.0 0.2 5.7 3 2 3 6 6 6 0 PQQ-like domain WD40 PF00400.32 CDF38048.1 - 4.9e-43 144.3 15.9 2.9e-10 40.5 0.3 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38048.1 - 2.5e-13 50.1 2.4 0.12 12.7 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF38048.1 - 4.5e-05 22.3 1.6 11 4.5 0.1 4.8 4 1 0 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 CDF38048.1 - 5.9e-05 22.5 0.0 1.3 8.3 0.0 4.0 4 1 1 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 CDF38048.1 - 0.00098 18.2 0.2 16 4.3 0.0 4.0 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 CDF38048.1 - 0.0052 15.2 0.0 0.89 7.8 0.0 3.5 2 1 2 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF727 PF05303.12 CDF38048.1 - 0.0057 16.7 0.6 30 4.8 0.0 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF727) PQQ_3 PF13570.6 CDF38048.1 - 0.049 14.1 16.6 4.6 7.9 0.6 5.7 3 1 3 6 6 6 0 PQQ-like domain Peptidase_S9_N PF02897.15 CDF38048.1 - 0.077 11.8 2.1 15 4.2 0.0 3.7 1 1 3 4 4 4 0 Prolyl oligopeptidase, N-terminal beta-propeller domain WSC PF01822.19 CDF38048.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 WSC domain Cytochrom_D1 PF02239.16 CDF38048.1 - 0.22 10.0 12.1 0.096 11.2 3.2 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain SPRR2 PF14820.6 CDF38056.1 - 0.0046 17.0 5.4 0.0046 17.0 5.4 1.8 1 1 1 2 2 2 1 Small proline-rich 2 Sulfotransfer_1 PF00685.27 CDF38057.1 - 1.7e-24 86.7 0.0 2.9e-24 86.0 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDF38057.1 - 0.053 13.9 0.0 9.3 6.6 0.0 2.5 1 1 0 2 2 2 0 Sulfotransferase family Methyltransf_31 PF13847.6 CDF38058.1 - 1.3e-09 38.0 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF38058.1 - 2.6e-09 36.9 0.0 5.1e-08 32.7 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDF38058.1 - 2.7e-08 34.4 0.0 1.8e-07 31.8 0.0 2.1 1 1 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CDF38058.1 - 1.2e-06 28.2 0.0 1.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 CDF38058.1 - 5.2e-05 23.8 0.1 0.0015 19.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 CDF38058.1 - 0.00018 21.2 0.3 0.0073 16.0 0.3 2.3 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 PrmC_N PF17827.1 CDF38058.1 - 0.00035 21.1 0.0 0.00059 20.4 0.0 1.4 1 0 0 1 1 1 1 PrmC N-terminal domain Methyltransf_18 PF12847.7 CDF38058.1 - 0.0011 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDF38058.1 - 0.0012 18.2 0.0 0.0024 17.2 0.0 1.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CDF38058.1 - 0.0013 19.4 0.0 0.0053 17.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF38058.1 - 0.0046 16.8 0.0 0.0058 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF38058.1 - 0.0052 16.1 0.1 0.057 12.7 0.1 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CDF38058.1 - 0.007 16.1 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 CDF38058.1 - 0.0076 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DUF3145 PF11343.8 CDF38058.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) Methyltransf_15 PF09445.10 CDF38058.1 - 0.16 11.6 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase rRNA_methylase PF06962.12 CDF38058.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative rRNA methylase Pyridoxal_deC PF00282.19 CDF38060.1 - 1.8e-16 59.8 0.0 5.5e-08 31.9 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain DUF2344 PF10105.9 CDF38060.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) Ribosomal_L35Ae PF01247.18 CDF38061.1 - 2.7e-19 69.1 0.4 3e-19 69.0 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae NTR PF01759.21 CDF38061.1 - 0.013 15.3 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 UNC-6/NTR/C345C module RimM PF01782.18 CDF38061.1 - 0.11 12.8 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 RimM N-terminal domain HTH_Tnp_Tc3_1 PF11427.8 CDF38062.1 - 3.8e-06 26.7 0.0 7.1e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase DDE_3 PF13358.6 CDF38062.1 - 6.7e-06 25.9 0.0 1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.6 CDF38062.1 - 0.013 15.3 0.0 0.035 13.9 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain DUF726 PF05277.12 CDF38063.1 - 1.7e-68 231.0 0.3 3.3e-58 197.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF726) RB_B PF01857.20 CDF38064.1 - 2.5e-30 105.2 0.0 4.3e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain RB_A PF01858.17 CDF38064.1 - 1.8e-24 86.7 0.0 4e-24 85.5 0.0 1.6 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain zf-U11-48K PF05253.12 CDF38065.1 - 0.083 12.8 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger His_Phos_2 PF00328.22 CDF38066.1 - 9.6e-17 61.4 0.2 1.4e-12 47.7 0.0 2.4 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Stevor PF17410.2 CDF38066.1 - 0.0061 16.1 0.1 0.025 14.1 0.0 1.9 2 0 0 2 2 2 1 Subtelomeric Variable Open Reading frame Romo1 PF10247.9 CDF38066.1 - 0.056 13.8 0.2 0.1 13.0 0.2 1.4 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 MtrF PF09472.10 CDF38066.1 - 0.16 11.4 0.9 0.41 10.1 0.9 1.7 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Sel1 PF08238.12 CDF38069.1 - 6.6e-09 36.2 1.5 0.0034 18.0 0.1 2.6 3 0 0 3 3 3 2 Sel1 repeat TPR_16 PF13432.6 CDF38069.1 - 0.00035 21.1 4.0 0.042 14.5 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38069.1 - 0.0052 17.5 4.1 0.49 11.3 0.2 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF38069.1 - 0.0073 16.9 0.2 2.9 8.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38069.1 - 0.058 13.9 0.3 4.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_lid_6 PF17866.1 CDF38069.1 - 0.15 12.3 2.0 0.44 10.8 1.8 1.8 1 1 0 1 1 1 0 AAA lid domain TPR_7 PF13176.6 CDF38069.1 - 0.16 12.0 3.0 14 6.0 0.1 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDF38069.1 - 1.7 8.6 5.0 11 6.0 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat RVT_2 PF07727.14 CDF38072.1 - 1e-32 113.7 0.0 1.4e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Use1 PF09753.9 CDF38073.1 - 5.7e-17 62.3 0.1 8.4e-17 61.7 0.1 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF1189 PF06691.11 CDF38073.1 - 0.022 14.3 0.6 0.029 13.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Prominin PF05478.11 CDF38073.1 - 0.12 10.4 0.3 0.15 10.0 0.3 1.1 1 0 0 1 1 1 0 Prominin RT_RNaseH PF17917.1 CDF38075.1 - 2e-37 127.7 0.2 1.7e-34 118.3 0.0 3.1 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38075.1 - 6.1e-36 122.5 0.0 5.2e-35 119.5 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF38075.1 - 9.5e-15 54.5 0.0 1.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF38075.1 - 3.3e-12 46.6 0.0 6.2e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDF38075.1 - 0.0011 19.1 0.0 0.0022 18.2 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 CDF38075.1 - 0.013 15.1 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_15 PF12324.8 CDF38075.1 - 0.047 13.7 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase DUF4840 PF16128.5 CDF38077.1 - 0.063 13.3 0.0 1.2 9.2 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4840) Beta_helix PF13229.6 CDF38078.1 - 3.5e-10 39.9 35.2 1.6e-09 37.8 12.2 3.2 2 1 1 3 3 3 2 Right handed beta helix region NosD PF05048.13 CDF38078.1 - 0.00056 19.2 10.7 0.0017 17.7 4.7 2.6 3 0 0 3 3 3 2 Periplasmic copper-binding protein (NosD) FAD_binding_3 PF01494.19 CDF38080.1 - 9.3e-25 87.6 0.0 1.3e-24 87.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDF38080.1 - 6.1e-05 22.8 0.0 0.031 13.9 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF38080.1 - 8.2e-05 22.0 0.4 0.00044 19.6 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDF38080.1 - 0.0003 20.9 0.1 0.0003 20.9 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDF38080.1 - 0.00043 19.5 0.2 0.0016 17.6 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CDF38080.1 - 0.0026 16.9 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CDF38080.1 - 0.011 14.8 0.0 0.078 12.0 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 CDF38080.1 - 0.086 12.7 1.2 0.092 12.6 0.0 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 CDF38080.1 - 0.087 11.9 0.0 6.1 5.8 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase HI0933_like PF03486.14 CDF38080.1 - 0.21 10.2 0.0 0.35 9.5 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein DUF2301 PF10063.9 CDF38081.1 - 1.1e-42 145.6 1.1 1.1e-42 145.6 1.1 1.6 2 0 0 2 2 2 1 Uncharacterized integral membrane protein (DUF2301) RPN6_N PF18055.1 CDF38083.1 - 6.3e-33 113.6 4.1 2.6e-32 111.6 0.1 3.3 3 2 1 4 4 4 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 CDF38083.1 - 4.5e-19 68.9 0.2 4.5e-19 68.9 0.2 2.2 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 CDF38083.1 - 2.3e-08 33.6 0.1 5.2e-08 32.5 0.1 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_MalT PF17874.1 CDF38083.1 - 0.00011 21.7 1.5 0.0002 20.9 1.5 1.3 1 0 0 1 1 1 1 MalT-like TPR region DUF630 PF04783.12 CDF38083.1 - 0.0022 18.1 5.3 0.0039 17.3 2.8 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF630) DDRGK PF09756.9 CDF38083.1 - 0.031 13.9 0.1 0.069 12.7 0.1 1.6 1 0 0 1 1 1 0 DDRGK domain TPR_21 PF09976.9 CDF38083.1 - 0.074 12.8 2.0 0.24 11.1 0.7 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain Laminin_II PF06009.12 CDF38083.1 - 0.29 11.1 4.5 0.22 11.5 0.4 2.6 3 0 0 3 3 3 0 Laminin Domain II TPR_12 PF13424.6 CDF38083.1 - 0.63 10.4 11.7 0.12 12.6 3.5 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38083.1 - 0.81 10.4 6.2 0.5 11.1 1.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat CRAL_TRIO PF00650.20 CDF38086.1 - 8.9e-18 64.5 0.0 1.3e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDF38086.1 - 0.0022 18.2 0.0 0.0036 17.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Ufd2P_core PF10408.9 CDF38088.1 - 1.4e-161 539.3 0.0 4.5e-161 537.6 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.15 CDF38088.1 - 3.6e-23 81.5 0.1 8.6e-23 80.3 0.1 1.7 1 0 0 1 1 1 1 U-box domain TcdB_N PF12918.7 CDF38088.1 - 0.23 11.8 0.9 0.56 10.5 0.4 1.9 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain HemY_N PF07219.13 CDF38088.1 - 9.5 6.5 7.0 0.32 11.2 0.2 2.1 2 0 0 2 2 2 0 HemY protein N-terminus zf-C2H2 PF00096.26 CDF38089.1 - 3.8e-10 39.6 43.3 0.00024 21.4 2.0 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF38089.1 - 3.4e-06 27.2 40.5 0.00016 22.0 0.4 5.4 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF38089.1 - 4.5e-06 27.0 43.4 0.06 14.2 1.9 6.4 6 1 0 6 6 5 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CDF38089.1 - 0.00016 21.3 14.2 0.6 9.9 0.2 3.9 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-met PF12874.7 CDF38089.1 - 0.0016 18.8 22.3 0.3 11.5 0.8 5.3 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDF38089.1 - 0.0049 17.1 25.3 2.9 8.3 1.8 5.5 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CDF38089.1 - 0.0055 16.4 0.4 0.0055 16.4 0.4 5.5 5 0 0 5 5 5 1 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 CDF38089.1 - 0.0082 16.8 21.1 0.24 12.1 0.6 4.4 1 1 3 4 4 4 3 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 CDF38089.1 - 0.23 11.6 14.7 1.5 9.0 1.5 4.1 3 1 1 4 4 4 0 Zinc ribbon domain DUF678 PF05077.12 CDF38089.1 - 0.52 10.5 5.8 3.4 7.8 1.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF678) PHD PF00628.29 CDF38089.1 - 7 6.6 9.3 1.8 8.5 2.8 2.9 3 0 0 3 3 3 0 PHD-finger WD40 PF00400.32 CDF38090.1 - 1.5 9.9 5.5 21 6.2 1.4 3.8 2 1 0 2 2 2 0 WD domain, G-beta repeat Cyt-b5 PF00173.28 CDF38091.1 - 3.5e-18 65.5 0.0 5e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Hist_deacetyl PF00850.19 CDF38092.1 - 3.6e-85 286.1 0.0 5.3e-85 285.6 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Profilin PF00235.19 CDF38093.1 - 1.5e-24 86.6 0.2 1.8e-24 86.5 0.2 1.0 1 0 0 1 1 1 1 Profilin RNA_polI_A34 PF08208.11 CDF38094.1 - 1.9e-09 38.0 0.1 1.9e-09 38.0 0.1 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 2Fe-2S_Ferredox PF11591.8 CDF38094.1 - 0.078 12.8 1.0 0.17 11.8 1.0 1.5 1 0 0 1 1 1 0 Ferredoxin chloroplastic transit peptide RXT2_N PF08595.11 CDF38094.1 - 0.15 12.1 3.2 0.25 11.4 3.2 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal RNase_PH PF01138.21 CDF38095.1 - 9.3e-19 68.2 0.1 1.5e-18 67.5 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF38095.1 - 7.4e-08 32.3 0.0 1.6e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 hNIFK_binding PF12196.8 CDF38096.1 - 0.024 14.1 0.4 0.052 13.1 0.4 1.4 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK S19 PF06756.11 CDF38096.1 - 0.086 12.8 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Chorion protein S19 C-terminal RNA_pol_Rpb1_2 PF00623.20 CDF38097.1 - 3.3e-60 203.1 0.0 6e-60 202.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 CDF38097.1 - 7.1e-57 192.9 0.0 1.2e-56 192.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.18 CDF38097.1 - 4.1e-32 111.3 0.0 9e-32 110.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 CDF38097.1 - 1.2e-23 84.0 0.0 2.2e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 CDF38097.1 - 1.6e-16 60.2 0.0 3.5e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 PF04998.17 CDF38098.1 - 1.8e-22 80.0 0.0 2.2e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 WD40 PF00400.32 CDF38099.1 - 6e-30 102.9 11.5 3.7e-07 30.7 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38099.1 - 2.2e-10 40.7 0.1 1.5e-05 25.2 0.0 5.3 2 2 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF38099.1 - 0.027 14.0 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain EamA PF00892.20 CDF38101.1 - 1.4e-21 77.1 26.9 4e-11 43.2 12.6 3.0 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 CDF38101.1 - 0.003 16.8 1.0 0.015 14.6 0.0 2.3 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport Nuc_sug_transp PF04142.15 CDF38101.1 - 0.12 11.5 1.9 0.41 9.8 0.1 2.1 2 0 0 2 2 2 0 Nucleotide-sugar transporter Synaptobrevin PF00957.21 CDF38102.1 - 3.1e-21 75.0 2.2 5.1e-21 74.3 2.2 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CDF38102.1 - 1.3e-10 41.1 0.0 3e-10 40.0 0.0 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain PilJ PF13675.6 CDF38102.1 - 0.011 15.8 0.3 0.035 14.1 0.2 1.9 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1676 PF07898.13 CDF38102.1 - 0.051 13.6 2.0 0.077 13.0 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DUF3671 PF12420.8 CDF38102.1 - 0.065 13.3 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2207 PF09972.9 CDF38102.1 - 0.068 11.9 0.1 0.074 11.8 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EMP24_GP25L PF01105.24 CDF38102.1 - 0.33 10.9 3.0 1.3 8.9 2.6 1.9 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Fzo_mitofusin PF04799.13 CDF38102.1 - 0.48 9.9 5.2 0.11 12.1 1.6 1.7 2 0 0 2 2 2 0 fzo-like conserved region Peptidase_M16_M PF16187.5 CDF38104.1 - 9e-85 284.3 0.2 9e-85 284.3 0.2 1.7 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 CDF38104.1 - 1.1e-38 132.5 1.7 5.6e-38 130.3 1.2 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDF38104.1 - 4.1e-31 108.4 0.0 8.9e-20 71.5 0.0 2.7 3 0 0 3 3 3 2 Peptidase M16 inactive domain Sulfotransfer_2 PF03567.14 CDF38105.1 - 1.1e-29 104.2 0.0 1.3e-29 103.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family Pkinase PF00069.25 CDF38108.1 - 1.7e-46 158.8 0.0 2.1e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38108.1 - 8.1e-23 81.0 0.0 1.3e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF38108.1 - 0.001 18.4 0.4 0.0038 16.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CDF38108.1 - 0.0024 17.5 0.1 0.0061 16.2 0.0 1.6 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDF38108.1 - 0.018 14.4 1.0 0.034 13.5 1.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF38108.1 - 0.018 14.9 6.2 0.061 13.2 6.2 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDF38108.1 - 0.029 13.3 0.1 0.038 12.9 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CDF38108.1 - 0.053 12.3 0.1 0.077 11.7 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase PIP49_C PF12260.8 CDF38108.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Actin PF00022.19 CDF38109.1 - 5.4e-16 58.2 0.3 5.7e-08 31.8 0.0 3.8 3 2 0 3 3 3 3 Actin Actin_micro PF17003.5 CDF38109.1 - 1.2e-05 24.7 0.1 0.0039 16.4 0.0 2.4 3 0 0 3 3 3 2 Putative actin-like family FtsA PF14450.6 CDF38109.1 - 0.022 15.2 1.7 0.19 12.2 0.1 3.1 3 1 0 3 3 3 0 Cell division protein FtsA TPR_8 PF13181.6 CDF38110.1 - 3.2e-07 30.0 0.0 0.68 10.3 0.0 5.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38110.1 - 6.9e-06 26.5 4.0 0.13 12.8 0.2 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF38110.1 - 3.2e-05 23.7 11.9 0.0031 17.5 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDF38110.1 - 0.00041 20.0 0.0 0.086 12.7 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38110.1 - 0.0029 18.3 19.3 0.028 15.2 0.0 7.0 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDF38110.1 - 0.046 13.9 2.9 5 7.3 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF38110.1 - 0.3 11.4 6.9 2.2 8.7 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat APS_kinase PF01583.20 CDF38111.1 - 6.2e-70 234.2 0.0 7.6e-70 233.9 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CDF38111.1 - 1.9e-06 28.1 0.0 2.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF38111.1 - 0.00016 22.2 0.1 0.00022 21.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 CDF38111.1 - 0.001 18.6 0.0 0.0012 18.3 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_29 PF13555.6 CDF38111.1 - 0.0014 18.3 0.1 0.0025 17.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain CPT PF07931.12 CDF38111.1 - 0.0014 18.5 0.6 0.11 12.3 0.6 2.6 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein CbiA PF01656.23 CDF38111.1 - 0.0063 16.6 0.0 0.0086 16.1 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 CDF38111.1 - 0.0065 15.8 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin ABC_tran PF00005.27 CDF38111.1 - 0.008 16.7 0.0 0.0095 16.4 0.0 1.3 1 1 0 1 1 1 1 ABC transporter ParA PF10609.9 CDF38111.1 - 0.02 14.3 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase IstB_IS21 PF01695.17 CDF38111.1 - 0.089 12.5 0.0 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 CDF38111.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDF38111.1 - 0.18 12.2 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_2 PF03668.15 CDF38111.1 - 0.19 11.0 0.1 0.73 9.1 0.1 1.9 1 1 0 1 1 1 0 P-loop ATPase protein family PMT PF02366.18 CDF38113.1 - 2.2e-39 135.5 11.3 2.2e-39 135.5 11.3 2.2 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CDF38113.1 - 1.8e-34 119.1 6.9 3.8e-34 118.0 6.9 1.5 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase PEPCK_GTP PF00821.18 CDF38113.1 - 0.039 12.8 0.0 0.055 12.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain GtrA PF04138.14 CDF38113.1 - 2.9 8.2 8.6 2.9 8.2 1.7 3.8 3 1 0 3 3 3 0 GtrA-like protein TPR_1 PF00515.28 CDF38116.1 - 6e-48 158.8 20.1 2.1e-08 33.6 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 CDF38116.1 - 7.6e-42 138.1 19.0 1.8e-05 24.5 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 CDF38116.1 - 2.8e-31 105.1 11.9 0.0017 18.4 0.0 9.2 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38116.1 - 2.4e-26 90.2 12.5 8.4e-05 23.1 0.1 9.0 4 2 5 9 9 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 CDF38116.1 - 3.1e-20 72.2 17.1 1.8e-05 24.9 1.0 7.0 4 2 2 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 CDF38116.1 - 5e-18 64.1 10.6 0.0013 19.0 0.0 8.4 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_9 PF13371.6 CDF38116.1 - 5.8e-18 64.8 8.1 0.00017 21.6 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38116.1 - 9.7e-17 61.2 12.1 0.0016 18.9 0.4 6.9 4 1 2 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38116.1 - 1.4e-16 60.8 19.2 2.3e-07 31.3 0.4 6.5 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDF38116.1 - 2.2e-16 59.2 18.1 5.6e-05 22.7 0.3 8.5 5 2 3 8 8 8 4 TPR repeat TPR_7 PF13176.6 CDF38116.1 - 1.4e-15 56.0 4.3 0.08 13.0 0.5 7.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_6 PF13174.6 CDF38116.1 - 2.9e-15 55.8 16.7 0.79 10.5 0.0 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_15 PF13429.6 CDF38116.1 - 2.9e-06 26.7 4.8 0.7 9.0 0.0 4.3 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDF38116.1 - 8.1e-05 22.4 10.5 0.11 12.4 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF38116.1 - 0.00019 21.6 10.9 0.037 14.3 0.8 4.4 2 2 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 CDF38116.1 - 0.00032 21.1 4.8 0.2 12.1 0.3 3.6 2 1 1 3 3 3 2 Bacterial transcriptional activator domain DUF1965 PF09248.10 CDF38116.1 - 0.047 13.5 2.0 8.9 6.2 0.1 4.0 3 1 1 4 4 3 0 Domain of unknown function (DUF1965) ChAPs PF09295.10 CDF38116.1 - 0.1 11.6 0.2 5.2 6.0 0.1 2.3 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) DNA_pol_D_N PF18018.1 CDF38116.1 - 0.11 12.7 0.0 5.9 7.0 0.0 2.9 1 1 1 2 2 2 0 DNA polymerase delta subunit OB-fold domain Coatomer_E PF04733.14 CDF38116.1 - 0.12 11.8 0.1 8.6 5.7 0.2 2.9 3 0 0 3 3 3 0 Coatomer epsilon subunit TipAS PF07739.13 CDF38116.1 - 8.1 7.0 11.7 11 6.6 0.2 3.9 2 1 1 4 4 4 0 TipAS antibiotic-recognition domain FKBP_C PF00254.28 CDF38118.1 - 1.1e-17 64.1 0.0 1.5e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF563 PF04577.14 CDF38119.1 - 8.1e-05 22.8 0.0 0.00014 22.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) ADK PF00406.22 CDF38120.1 - 1.4e-49 168.0 0.0 2.4e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDF38120.1 - 1e-28 100.4 0.0 2.6e-28 99.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF3054 PF11255.8 CDF38120.1 - 2.4e-21 76.3 8.3 3.9e-21 75.6 8.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3054) AAA_18 PF13238.6 CDF38120.1 - 2e-07 31.6 0.2 4.5e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain Hydin_ADK PF17213.3 CDF38120.1 - 8.6e-05 22.9 3.8 0.17 12.1 0.2 3.0 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 CDF38120.1 - 0.0015 18.7 0.1 0.0091 16.2 0.0 2.2 1 1 1 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 CDF38120.1 - 0.0059 16.3 0.1 4.1 7.0 0.0 3.1 3 0 0 3 3 3 1 Thymidylate kinase Zeta_toxin PF06414.12 CDF38120.1 - 0.13 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin PF02224.18 CDF38120.1 - 0.23 11.2 0.0 0.23 11.2 0.0 2.0 3 0 0 3 3 3 0 Cytidylate kinase VRR_NUC PF08774.11 CDF38121.1 - 6.6e-19 68.0 0.1 2.9e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 VRR-NUC domain DNA_topoisoIV PF00521.20 CDF38122.1 - 7.9e-118 394.0 0.0 2.4e-117 392.4 0.0 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CDF38122.1 - 2e-41 141.2 0.2 2e-41 141.2 0.2 2.4 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CDF38122.1 - 5.2e-25 87.9 0.5 1.2e-24 86.7 0.5 1.6 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 CDF38122.1 - 1.3e-09 38.2 0.1 1.1e-08 35.2 0.0 2.5 2 0 0 2 2 2 1 Toprim domain HATPase_c PF02518.26 CDF38122.1 - 8.5e-09 35.9 0.1 5.9e-08 33.2 0.0 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase eIF-5a PF01287.20 CDF38123.1 - 3.9e-21 74.9 3.6 5.4e-21 74.5 3.6 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CDF38123.1 - 0.0064 16.5 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain DUF1248 PF06852.12 CDF38123.1 - 0.041 13.4 0.3 0.061 12.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1248) RED_C PF07807.11 CDF38123.1 - 0.19 12.2 1.4 0.34 11.4 1.1 1.5 1 1 0 1 1 1 0 RED-like protein C-terminal region UFC1 PF08694.11 CDF38125.1 - 0.23 11.1 0.0 0.36 10.4 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 DUF2505 PF10698.9 CDF38127.1 - 0.0044 17.2 0.0 0.0074 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) Snf7 PF03357.21 CDF38128.1 - 5.8e-10 39.0 2.8 9.5e-10 38.3 2.8 1.3 1 0 0 1 1 1 1 Snf7 TolA_bind_tri PF16331.5 CDF38128.1 - 8.5 6.5 10.2 2.2 8.4 6.0 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation AAA_lid_9 PF17871.1 CDF38130.1 - 7.7e-10 38.6 0.1 1.8e-09 37.5 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_28 PF13521.6 CDF38130.1 - 0.017 15.3 0.0 0.37 11.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDF38130.1 - 0.062 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 CDF38130.1 - 0.082 13.3 1.9 2.5 8.5 1.9 2.5 1 1 0 1 1 1 0 AAA ATPase domain TIP49 PF06068.13 CDF38130.1 - 0.085 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA PF00004.29 CDF38130.1 - 0.13 12.7 0.0 0.9 10.0 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SWIB PF02201.18 CDF38131.1 - 8.2e-13 48.0 0.0 1.5e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain YEATS PF03366.16 CDF38131.1 - 0.0082 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 YEATS family RNA_pol_Rpb2_6 PF00562.28 CDF38132.1 - 2.3e-125 418.7 0.1 8.6e-124 413.5 0.0 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDF38132.1 - 2.2e-44 151.4 0.0 3.4e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CDF38132.1 - 2.1e-42 144.9 0.0 3.5e-42 144.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CDF38132.1 - 2.7e-33 114.2 0.2 7.4e-33 112.8 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CDF38132.1 - 9.3e-27 93.0 0.0 2.5e-26 91.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 CDF38132.1 - 1.4e-26 92.6 0.2 3.5e-26 91.3 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 CDF38132.1 - 2.3e-16 60.1 1.1 5.9e-16 58.8 1.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RecR PF02132.15 CDF38132.1 - 6.9 6.3 5.8 4.3 7.0 2.6 2.4 2 1 0 2 2 2 0 RecR protein CN_hydrolase PF00795.22 CDF38133.1 - 8e-08 31.9 0.0 9.7e-08 31.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CN_hydrolase PF00795.22 CDF38134.1 - 3.9e-32 111.6 0.0 5.3e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Phospho_p8 PF10195.9 CDF38134.1 - 0.26 11.8 2.8 0.34 11.4 1.1 1.9 2 0 0 2 2 2 0 DNA-binding nuclear phosphoprotein p8 YEATS PF03366.16 CDF38135.1 - 8.9e-28 96.1 1.0 1.5e-27 95.4 1.0 1.4 1 0 0 1 1 1 1 YEATS family WD40 PF00400.32 CDF38136.1 - 0.055 14.4 3.9 44 5.2 0.0 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat RRM_1 PF00076.22 CDF38138.1 - 0.00049 19.9 0.0 0.00092 19.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF726 PF05277.12 CDF38139.1 - 1.1e-58 198.9 8.1 3.9e-43 147.7 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.7 CDF38139.1 - 0.084 13.5 3.6 0.82 10.2 0.0 2.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Helicase_C PF00271.31 CDF38140.1 - 4.1e-15 56.1 0.0 1.1e-14 54.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CDF38140.1 - 2.7e-08 33.5 11.2 5.8e-08 32.4 11.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF38140.1 - 1.5e-07 31.1 10.2 3.1e-07 30.1 10.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF38140.1 - 3.7e-07 30.4 11.3 7.6e-07 29.4 11.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF38140.1 - 7.5e-07 28.9 9.9 1.5e-06 28.0 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 CDF38140.1 - 4.7e-06 25.5 0.1 8.4e-06 24.7 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CDF38140.1 - 5.3e-05 23.2 5.1 5.3e-05 23.2 5.1 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CDF38140.1 - 0.00057 19.6 10.6 0.0013 18.5 10.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 CDF38140.1 - 0.0015 18.5 11.2 0.0051 16.7 11.3 1.9 1 1 1 2 2 2 1 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 CDF38140.1 - 0.045 13.0 0.0 0.076 12.2 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Prok-RING_4 PF14447.6 CDF38140.1 - 0.061 13.2 11.7 2.6 8.0 11.8 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDF38140.1 - 0.066 13.4 10.1 0.14 12.3 10.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.14 CDF38140.1 - 0.091 12.6 1.0 4 7.4 0.2 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_10 PF16685.5 CDF38140.1 - 0.096 12.8 7.2 0.29 11.3 7.2 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.8 CDF38140.1 - 0.11 12.3 5.3 0.26 11.1 5.3 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 CDF38140.1 - 0.65 9.9 8.3 0.31 10.9 5.7 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein BTB PF00651.31 CDF38143.1 - 0.018 15.3 0.0 0.033 14.4 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain DEAD PF00270.29 CDF38147.1 - 1.1e-46 158.8 0.0 2.3e-46 157.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF38147.1 - 3.7e-29 101.3 0.1 1.5e-28 99.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GUCT PF08152.12 CDF38147.1 - 2.2e-08 34.3 0.0 4.4e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 GUCT (NUC152) domain ResIII PF04851.15 CDF38147.1 - 8.2e-05 22.7 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDF38147.1 - 0.015 14.5 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 CDF38147.1 - 0.054 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit CBFD_NFYB_HMF PF00808.23 CDF38148.1 - 4.1e-16 59.0 0.9 6.6e-16 58.4 0.9 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDF38148.1 - 2.3e-06 28.0 0.3 2.3e-06 28.0 0.3 2.0 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PBP1_TM PF14812.6 CDF38148.1 - 0.053 13.9 1.7 0.053 13.9 1.7 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Lyase_1 PF00206.20 CDF38150.1 - 2e-109 365.8 0.0 3.2e-109 365.1 0.0 1.3 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CDF38150.1 - 1.1e-19 70.6 0.1 2.4e-19 69.5 0.1 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus CBM_19 PF03427.13 CDF38153.1 - 0.032 14.2 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) WD40 PF00400.32 CDF38154.1 - 1.9e-07 31.6 2.1 5.9e-06 26.9 0.2 3.5 3 1 1 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38154.1 - 1.7e-06 28.2 0.0 0.26 11.6 0.0 3.8 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF38154.1 - 0.077 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A DUF2415 PF10313.9 CDF38154.1 - 0.12 12.3 0.2 0.27 11.2 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Cytochrom_D1 PF02239.16 CDF38154.1 - 0.14 10.7 0.0 0.29 9.6 0.0 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain YabA PF06156.13 CDF38155.1 - 0.081 13.6 0.6 0.13 12.9 0.3 1.6 1 1 1 2 2 2 0 Initiation control protein YabA Sigma54_AID PF00309.20 CDF38155.1 - 0.36 10.7 1.5 19 5.2 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 factor, Activator interacting domain (AID) CHZ PF09649.10 CDF38156.1 - 1 8.9 0.1 1 8.9 0.1 2.9 3 0 0 3 3 3 0 Histone chaperone domain CHZ Cofac_haem_bdg PF04187.13 CDF38157.1 - 1.2e-32 113.7 0.0 1.5e-32 113.3 0.0 1.1 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN AMP-binding PF00501.28 CDF38158.1 - 2.8e-99 332.6 0.0 7.8e-99 331.1 0.0 1.6 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDF38158.1 - 0.16 12.9 0.1 0.64 11.0 0.0 2.1 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain DUF3689 PF12463.8 CDF38159.1 - 4.8e-38 131.2 0.1 9.4e-37 127.0 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3689) SAM_PNT PF02198.16 CDF38160.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain E1-E2_ATPase PF00122.20 CDF38164.1 - 1.5e-34 119.1 0.5 1.5e-34 119.1 0.5 2.0 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDF38164.1 - 2.2e-25 89.4 14.8 1.4e-24 86.8 9.0 3.1 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CDF38164.1 - 5.3e-18 64.9 0.2 1.1e-17 63.8 0.2 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDF38164.1 - 1.8e-15 57.8 3.6 6.2e-15 56.1 3.6 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF38164.1 - 9e-05 22.3 0.8 0.2 11.3 0.2 2.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase DUF3199 PF11436.8 CDF38164.1 - 0.03 14.3 0.0 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3199) 5_nucleotid PF05761.14 CDF38166.1 - 6.1e-141 470.4 0.3 7e-141 470.2 0.3 1.0 1 0 0 1 1 1 1 5' nucleotidase family DUF1351 PF07083.11 CDF38166.1 - 0.014 15.2 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) HAD_2 PF13419.6 CDF38166.1 - 0.1 12.7 0.0 0.64 10.1 0.0 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Ribosomal_S28e PF01200.18 CDF38167.1 - 1.1e-30 105.4 0.3 1.2e-30 105.3 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e MutS_V PF00488.21 CDF38168.1 - 5.6e-63 212.4 0.0 9.8e-63 211.6 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CDF38168.1 - 1.2e-32 113.7 2.5 1.9e-32 113.1 1.5 1.9 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 CDF38168.1 - 1.1e-16 61.1 0.0 4.6e-16 59.1 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 CDF38168.1 - 2.7e-14 53.3 0.3 6.5e-14 52.0 0.3 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CDF38168.1 - 3.4e-11 43.6 1.2 6.5e-09 36.2 0.0 3.6 2 1 0 2 2 2 1 MutS domain II AAA_27 PF13514.6 CDF38168.1 - 0.084 12.5 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF3198 PF11433.8 CDF38168.1 - 0.17 11.8 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) RT_RNaseH PF17917.1 CDF38169.1 - 3.1e-33 114.2 0.1 1.7e-32 111.8 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38169.1 - 6.9e-32 109.5 0.0 1.5e-31 108.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF38169.1 - 6.2e-19 68.3 0.1 1.4e-18 67.2 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF38169.1 - 5.6e-11 42.4 0.2 1.1e-10 41.4 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 CDF38169.1 - 0.00021 21.0 0.3 0.0011 18.7 0.1 2.4 2 0 0 2 2 2 1 Integrase core domain FGAR-AT_linker PF18072.1 CDF38169.1 - 0.043 14.4 0.0 24 5.6 0.0 3.2 3 0 0 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain Sel1 PF08238.12 CDF38170.1 - 1e-29 102.2 2.8 1.4e-05 25.6 0.1 6.2 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.6 CDF38170.1 - 0.00049 20.6 2.5 0.59 10.9 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF38170.1 - 0.038 14.0 3.2 0.73 10.0 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38170.1 - 0.12 13.0 0.9 39 4.8 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA PF00004.29 CDF38172.1 - 5.8e-19 68.8 0.0 1.3e-18 67.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDF38172.1 - 0.00035 20.4 0.0 0.00072 19.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF38172.1 - 0.00036 20.9 0.0 0.00097 19.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CDF38172.1 - 0.0012 18.4 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 CDF38172.1 - 0.0015 18.4 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDF38172.1 - 0.0022 17.6 0.1 0.079 12.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 CDF38172.1 - 0.0024 18.1 0.0 0.009 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain Zot PF05707.12 CDF38172.1 - 0.028 14.1 0.0 0.2 11.3 0.0 2.2 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) Parvo_NS1 PF01057.17 CDF38172.1 - 0.029 13.5 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_5 PF07728.14 CDF38172.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CDF38172.1 - 0.078 13.2 0.1 1 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDF38172.1 - 0.083 13.1 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDF38172.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.6 CDF38172.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain HLH PF00010.26 CDF38177.1 - 5.4e-09 35.9 0.0 2.1e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain NPV_P10 PF05531.12 CDF38177.1 - 0.058 13.9 0.1 0.1 13.0 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein RPW8 PF05659.11 CDF38177.1 - 0.19 11.4 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Ran_BP1 PF00638.18 CDF38178.1 - 1.2e-48 164.4 1.8 1.8e-48 163.9 1.8 1.2 1 0 0 1 1 1 1 RanBP1 domain DUF1681 PF07933.14 CDF38178.1 - 0.00034 20.3 0.2 0.00045 19.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) WH1 PF00568.23 CDF38178.1 - 0.0026 17.7 0.1 0.0069 16.3 0.1 1.7 1 1 0 1 1 1 1 WH1 domain DSHCT PF08148.12 CDF38179.1 - 3.1e-38 131.0 2.3 8.5e-38 129.6 0.3 2.5 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 CDF38179.1 - 1.1e-15 57.8 0.0 2.4e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF38179.1 - 1.3e-05 25.5 0.0 9.9e-05 22.7 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ATPase_2 PF01637.18 CDF38179.1 - 0.051 13.5 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PIF1 PF05970.14 CDF38180.1 - 9.7e-83 278.3 0.0 4.2e-48 164.4 0.0 2.4 2 1 1 3 3 3 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF38180.1 - 4.7e-51 173.7 0.1 8.1e-51 172.9 0.1 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF38180.1 - 5.6e-11 42.5 0.0 1.1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_UL16 PF03044.14 CDF38180.1 - 0.022 14.0 0.1 0.04 13.2 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus UL16/UL94 family AAA_19 PF13245.6 CDF38180.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Flavin_Reduct PF01613.18 CDF38182.1 - 4.9e-06 26.7 0.1 6.7e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Flavin reductase like domain PQQ_2 PF13360.6 CDF38183.1 - 8.9e-10 38.5 15.5 2.9e-06 27.1 4.6 2.4 1 1 1 2 2 2 2 PQQ-like domain ANAPC4_WD40 PF12894.7 CDF38183.1 - 1.3e-07 31.9 4.3 0.16 12.3 0.2 4.5 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 CDF38183.1 - 3.2e-07 29.9 9.7 0.043 13.8 0.1 4.6 4 0 0 4 4 4 4 PQQ enzyme repeat WD40 PF00400.32 CDF38183.1 - 3.9e-05 24.3 4.7 0.015 16.1 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.12 CDF38183.1 - 0.031 14.2 0.5 20 5.3 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF799 PF05643.11 CDF38183.1 - 1.4 8.5 6.3 9.3 5.8 0.7 3.1 2 1 1 3 3 3 0 Putative bacterial lipoprotein (DUF799) Aldo_ket_red PF00248.21 CDF38184.1 - 8.3e-70 235.3 0.0 9.7e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SYF2 PF08231.12 CDF38185.1 - 1.4e-15 58.0 15.5 1.1e-14 55.2 15.5 2.3 1 1 0 1 1 1 1 SYF2 splicing factor SDH_beta PF03315.15 CDF38185.1 - 0.11 12.9 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Serine dehydratase beta chain FANCI_S4 PF14678.6 CDF38188.1 - 4.9e-37 127.4 0.0 7.3e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 FANCI solenoid 4 DDE_3 PF13358.6 CDF38189.1 - 4.6e-16 58.9 0.0 8.2e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF38189.1 - 3.2e-08 33.3 0.0 7.4e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF38189.1 - 0.00035 20.3 0.0 0.00075 19.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDF38189.1 - 0.002 18.3 0.7 0.0038 17.4 0.7 1.5 1 0 0 1 1 1 1 Transposase UTP25 PF06862.12 CDF38190.1 - 2.3e-132 442.2 0.0 4.7e-81 272.9 0.0 2.1 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF3850 PF12961.7 CDF38190.1 - 0.29 11.2 2.0 1.9 8.6 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3850) SesA PF17107.5 CDF38191.1 - 0.17 12.1 0.0 0.91 9.7 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Hydrolase_4 PF12146.8 CDF38192.1 - 4e-08 32.8 1.0 0.0045 16.3 0.2 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDF38192.1 - 4.5e-07 30.7 3.0 1.2e-05 26.0 0.1 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family Endonuclease_NS PF01223.23 CDF38195.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease DND1_DSRM PF14709.7 CDF38196.1 - 0.12 12.6 0.0 3.3 8.1 0.0 2.3 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 DND1_DSRM PF14709.7 CDF38197.1 - 0.039 14.2 0.0 1.5 9.1 0.0 2.3 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 HhH-GPD PF00730.25 CDF38200.1 - 9.5e-19 67.9 0.0 2.6e-18 66.5 0.0 1.8 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDF38200.1 - 2.5e-05 23.9 0.0 5.7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Paramyxo_ncap PF00973.19 CDF38200.1 - 9.2 5.1 8.7 13 4.5 8.7 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PH PF00169.29 CDF38201.1 - 3.8e-06 27.4 0.1 5.8e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 PH domain RNA_pol_Rbc25 PF08292.12 CDF38203.1 - 1.9 8.8 3.6 2.4 8.4 1.8 2.1 1 1 1 2 2 2 0 RNA polymerase III subunit Rpc25 Ran_BP1 PF00638.18 CDF38204.1 - 2.6e-20 72.9 0.1 3.9e-20 72.3 0.1 1.3 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.11 CDF38204.1 - 1.2e-11 45.1 1.3 1.2e-11 45.1 1.3 2.8 3 1 0 3 3 3 1 NUP50 (Nucleoporin 50 kDa) WH1 PF00568.23 CDF38204.1 - 0.016 15.1 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 WH1 domain Sec7 PF01369.20 CDF38205.1 - 1e-47 162.2 0.0 2.6e-47 160.9 0.0 1.7 1 0 0 1 1 1 1 Sec7 domain DUF1981 PF09324.10 CDF38205.1 - 2.1e-30 104.4 2.4 4.6e-29 100.1 0.3 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) Mon2_C PF16206.5 CDF38205.1 - 0.00016 20.0 0.0 0.00031 19.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of Mon2 protein HEAT PF02985.22 CDF38205.1 - 0.00029 20.8 0.2 33 5.1 0.0 5.2 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 CDF38205.1 - 0.029 14.9 0.0 36 5.0 0.0 4.0 4 0 0 4 4 4 0 HEAT-like repeat DUF4242 PF14026.6 CDF38205.1 - 0.03 14.5 0.0 0.2 11.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4242) PhyH PF05721.13 CDF38206.1 - 2.1e-07 31.4 0.0 2.8e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Copine PF07002.16 CDF38207.1 - 5.6e-55 186.1 0.0 7.7e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 CDF38207.1 - 3.6e-21 75.4 0.0 9.2e-10 38.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 CDF38207.1 - 0.044 13.9 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus PK PF00224.21 CDF38208.1 - 3.8e-150 499.6 2.9 6.3e-150 498.9 2.9 1.3 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDF38208.1 - 1e-31 109.6 0.7 2.9e-31 108.1 0.7 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain Viral_DNA_bi PF02236.17 CDF38208.1 - 0.1 12.8 0.4 1.3 9.3 0.0 2.6 3 0 0 3 3 3 0 Viral DNA-binding protein, all alpha domain ECH_1 PF00378.20 CDF38209.1 - 2.4e-36 125.3 0.1 3e-36 125.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDF38209.1 - 2.7e-25 89.6 0.1 3.4e-25 89.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF3370 PF11850.8 CDF38209.1 - 0.0058 15.6 0.0 0.012 14.5 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3370) TAF6_C PF07571.13 CDF38209.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain zinc_ribbon_12 PF11331.8 CDF38210.1 - 0.015 15.1 0.7 0.019 14.7 0.2 1.5 2 0 0 2 2 2 0 Probable zinc-ribbon domain YccV-like PF08755.11 CDF38211.1 - 1.4e-11 44.7 0.0 2.1e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like UVR PF02151.19 CDF38211.1 - 6.7e-05 22.5 16.1 0.0022 17.7 3.6 2.3 2 0 0 2 2 2 2 UvrB/uvrC motif bZIP_2 PF07716.15 CDF38218.1 - 0.0019 18.2 9.4 0.02 15.0 3.3 2.3 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 CDF38218.1 - 5.3 7.2 9.0 1.5e+02 2.6 9.0 2.2 1 1 0 1 1 1 0 bZIP transcription factor FUN14 PF04930.15 CDF38219.1 - 9.2e-15 54.8 0.1 1.2e-14 54.5 0.1 1.1 1 0 0 1 1 1 1 FUN14 family ADH_zinc_N PF00107.26 CDF38220.1 - 7e-11 42.2 0.2 2.2e-10 40.6 0.2 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDF38220.1 - 1.4e-10 42.3 0.1 6.3e-10 40.2 0.0 2.1 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDF38220.1 - 3.3e-06 26.9 0.0 1.4e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain FA_desaturase PF00487.24 CDF38220.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Fatty acid desaturase adh_short PF00106.25 CDF38220.1 - 0.11 11.9 0.2 0.17 11.3 0.2 1.2 1 0 0 1 1 1 0 short chain dehydrogenase FAD_binding_7 PF03441.14 CDF38223.1 - 1.2e-74 250.2 3.7 1.7e-74 249.7 3.7 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CDF38223.1 - 3.4e-36 124.7 0.0 7.8e-36 123.6 0.0 1.6 1 0 0 1 1 1 1 DNA photolyase ABC_tran PF00005.27 CDF38224.1 - 2.1e-50 170.8 0.1 8.5e-24 84.6 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDF38224.1 - 2.8e-22 78.5 15.3 5.7e-21 74.3 5.0 2.9 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 CDF38224.1 - 1.1e-20 74.7 0.5 0.00072 19.4 0.2 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF38224.1 - 8.2e-13 48.3 0.3 0.00038 20.0 0.0 4.0 4 1 0 4 4 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF38224.1 - 4.7e-07 29.5 0.0 0.0067 16.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 CDF38224.1 - 5.1e-07 30.1 0.2 0.0027 18.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDF38224.1 - 7.4e-07 29.7 0.0 0.0095 16.3 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CDF38224.1 - 1.2e-06 28.6 0.0 0.035 14.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 CDF38224.1 - 3.8e-06 26.9 0.6 0.17 11.5 0.0 3.5 3 1 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 CDF38224.1 - 5.2e-06 26.8 0.7 0.22 11.8 0.0 3.2 3 1 0 3 3 2 2 AAA domain AAA_23 PF13476.6 CDF38224.1 - 6e-06 26.9 11.4 0.011 16.2 3.0 3.5 3 1 0 3 3 2 2 AAA domain AAA_14 PF13173.6 CDF38224.1 - 6.1e-06 26.3 0.0 0.015 15.3 0.0 3.1 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 CDF38224.1 - 1e-05 25.5 0.0 0.0026 17.7 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 CDF38224.1 - 2.4e-05 24.6 0.1 0.44 10.7 0.0 3.1 2 1 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 CDF38224.1 - 3.5e-05 23.8 1.6 0.0067 16.4 0.0 2.9 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea NACHT PF05729.12 CDF38224.1 - 4.9e-05 23.3 0.3 0.043 13.7 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 CDF38224.1 - 5.1e-05 23.7 0.0 0.064 13.7 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDF38224.1 - 5.7e-05 23.7 0.2 0.26 11.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_27 PF13514.6 CDF38224.1 - 0.00011 21.9 0.0 0.075 12.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 CDF38224.1 - 0.00032 20.5 0.0 0.1 12.3 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 CDF38224.1 - 0.00065 19.5 0.0 1.9 8.2 0.0 2.9 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 CDF38224.1 - 0.00096 19.5 0.0 0.95 9.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 CDF38224.1 - 0.00096 19.2 0.4 3.6 7.6 0.0 3.7 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 CDF38224.1 - 0.00099 19.2 1.5 1.5 8.8 0.0 3.0 3 1 0 3 3 2 2 Dynamin family AAA_24 PF13479.6 CDF38224.1 - 0.001 18.8 0.0 1.4 8.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 CDF38224.1 - 0.0013 18.5 0.0 0.004 16.9 0.0 1.8 2 1 0 2 2 1 1 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 CDF38224.1 - 0.0013 18.0 0.0 0.028 13.6 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain cobW PF02492.19 CDF38224.1 - 0.0017 18.0 0.1 2 8.0 0.1 2.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 CDF38224.1 - 0.0026 16.9 0.0 0.47 9.5 0.1 2.5 2 1 0 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.17 CDF38224.1 - 0.0026 17.9 0.7 2.6 8.1 0.0 3.6 4 0 0 4 4 3 1 Helicase HerA, central domain AAA_13 PF13166.6 CDF38224.1 - 0.0044 15.7 0.9 0.53 8.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 CDF38224.1 - 0.0071 15.9 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 CDF38224.1 - 0.0079 16.4 0.0 5.9 7.1 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SbcCD_C PF13558.6 CDF38224.1 - 0.011 15.9 0.2 1.7 8.9 0.0 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TsaE PF02367.17 CDF38224.1 - 0.034 14.1 0.0 3.7 7.6 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 CDF38224.1 - 0.036 13.8 0.1 3 7.5 0.0 2.7 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 CDF38224.1 - 0.044 13.3 0.0 9.7 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 CDF38224.1 - 0.048 13.1 0.0 1.3 8.4 0.0 2.8 3 0 0 3 3 2 0 ADP-ribosylation factor family NTPase_1 PF03266.15 CDF38224.1 - 0.064 13.2 0.0 5.5 6.9 0.0 2.7 2 0 0 2 2 2 0 NTPase IstB_IS21 PF01695.17 CDF38224.1 - 0.065 13.0 0.3 25 4.5 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein TniB PF05621.11 CDF38224.1 - 0.096 12.1 0.2 5.9 6.3 0.0 3.4 4 0 0 4 4 3 0 Bacterial TniB protein Rad17 PF03215.15 CDF38224.1 - 0.1 12.5 0.0 16 5.3 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain DLIC PF05783.11 CDF38224.1 - 0.11 11.4 4.0 2.3 7.0 0.0 3.8 4 1 1 5 5 5 0 Dynein light intermediate chain (DLIC) MobB PF03205.14 CDF38224.1 - 0.12 12.3 0.1 1.7 8.6 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Adeno_IVa2 PF02456.15 CDF38224.1 - 0.14 10.9 0.1 15 4.3 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_17 PF13207.6 CDF38224.1 - 5.9 7.3 6.9 33 4.9 0.2 3.5 3 1 0 3 3 3 0 AAA domain TetR_C_11 PF16859.5 CDF38225.1 - 0.23 11.8 7.7 4 7.8 0.6 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RNase_PH PF01138.21 CDF38226.1 - 3.1e-35 121.6 0.0 3.4e-18 66.4 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 S1 PF00575.23 CDF38226.1 - 5.2e-16 58.7 2.3 1.5e-15 57.2 2.3 1.9 1 0 0 1 1 1 1 S1 RNA binding domain RNase_PH_C PF03725.15 CDF38226.1 - 8.7e-08 32.1 0.4 1.4e-06 28.2 0.1 2.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 PNPase PF03726.14 CDF38226.1 - 6.8e-07 29.7 0.2 1.6e-06 28.5 0.2 1.7 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.29 CDF38226.1 - 9.8e-06 25.3 4.2 2.8e-05 23.9 4.2 1.8 1 0 0 1 1 1 1 KH domain S1_2 PF13509.6 CDF38226.1 - 0.12 12.4 0.2 0.37 10.9 0.2 1.9 1 1 0 1 1 1 0 S1 domain SBDS_C PF09377.10 CDF38229.1 - 1.2e-30 105.9 0.5 2e-30 105.2 0.2 1.5 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 CDF38229.1 - 2.1e-29 101.4 0.3 3.9e-29 100.6 0.3 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Toxin_25 PF08095.11 CDF38229.1 - 0.075 13.0 0.1 0.075 13.0 0.1 1.8 2 0 0 2 2 2 0 Hefutoxin family Myb_DNA-binding PF00249.31 CDF38231.1 - 1.3e-44 150.2 5.3 2.1e-12 47.0 0.2 4.2 4 0 0 4 4 4 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF38231.1 - 2.4e-31 107.8 0.2 6.7e-12 45.5 0.0 4.1 2 2 2 4 4 4 4 Myb-like DNA-binding domain Rap1_C PF11626.8 CDF38231.1 - 3.3e-07 30.3 1.1 0.019 15.1 0.1 3.3 3 0 0 3 3 3 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 CDF38231.1 - 0.0015 18.5 0.0 0.19 11.8 0.0 3.1 2 1 1 3 3 3 1 SLIDE Death PF00531.22 CDF38231.1 - 0.067 13.4 0.1 16 5.7 0.0 2.4 2 0 0 2 2 2 0 Death domain DUF2526 PF10735.9 CDF38231.1 - 0.13 12.4 0.6 21 5.4 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2526) Aconitase_C PF00694.19 CDF38233.1 - 1.3e-15 57.9 0.0 2.3e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 CDF38233.1 - 0.0034 17.0 0.0 0.16 11.6 0.0 2.1 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus bZIP_1 PF00170.21 CDF38234.1 - 4.1e-06 26.8 12.0 6.3e-06 26.2 12.0 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CDF38234.1 - 3.6e-05 23.8 12.6 5.5e-05 23.2 12.6 1.3 1 0 0 1 1 1 1 Basic region leucine zipper TMF_DNA_bd PF12329.8 CDF38234.1 - 5.4 7.1 7.5 8.5 6.4 7.5 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DnaJ_C PF01556.18 CDF38235.1 - 5.1e-32 111.0 0.0 7.1e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDF38235.1 - 1.9e-18 66.3 0.0 3.3e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain UbiA PF01040.18 CDF38236.1 - 2.9e-38 131.6 14.8 3.9e-38 131.2 14.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family BK_channel_a PF03493.18 CDF38237.1 - 1.1e-14 54.3 0.1 2.9e-14 53.0 0.1 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.18 CDF38237.1 - 1.4e-05 25.3 0.0 0.038 14.2 0.0 2.5 2 0 0 2 2 2 2 TrkA-N domain RhoGEF67_u1 PF16615.5 CDF38239.1 - 6.3 7.4 9.4 1.8 9.1 1.6 2.4 1 1 1 2 2 2 0 Unstructured region one on RhoGEF 6 and 7 ALG11_N PF15924.5 CDF38240.1 - 6.2e-61 206.1 0.0 9e-61 205.6 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CDF38240.1 - 2.3e-27 95.6 0.1 3.3e-27 95.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF38240.1 - 3.7e-15 56.5 0.2 5.9e-15 55.9 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 AAA PF00004.29 CDF38241.1 - 7.7e-40 136.4 0.0 1.5e-39 135.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDF38241.1 - 1e-19 70.2 0.2 2.2e-19 69.1 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CDF38241.1 - 2e-06 27.8 0.0 7.2e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDF38241.1 - 2.5e-06 28.0 0.1 0.0033 17.8 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_lid_3 PF17862.1 CDF38241.1 - 3e-06 26.9 0.1 6.8e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CDF38241.1 - 1.3e-05 25.4 0.0 3.8e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDF38241.1 - 2.9e-05 23.9 0.0 7.6e-05 22.5 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF38241.1 - 0.00097 19.4 0.2 0.094 13.0 0.0 2.5 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDF38241.1 - 0.0047 17.1 0.2 0.027 14.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 CDF38241.1 - 0.01 15.3 0.1 0.34 10.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 CDF38241.1 - 0.013 14.8 0.1 0.038 13.4 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TMF_TATA_bd PF12325.8 CDF38241.1 - 0.023 14.9 0.8 0.023 14.9 0.8 2.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding IstB_IS21 PF01695.17 CDF38241.1 - 0.024 14.4 0.0 0.058 13.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 CDF38241.1 - 0.032 14.1 0.0 0.12 12.2 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDF38241.1 - 0.043 13.0 0.0 0.083 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 CDF38241.1 - 0.053 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDF38241.1 - 0.067 12.9 0.1 0.18 11.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDF38241.1 - 0.082 13.5 0.0 0.26 11.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF4172 PF13776.6 CDF38241.1 - 0.11 12.8 0.3 0.34 11.3 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4172) RNA_helicase PF00910.22 CDF38241.1 - 0.15 12.4 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NPV_P10 PF05531.12 CDF38241.1 - 0.38 11.2 4.7 0.33 11.5 2.5 2.0 2 0 0 2 2 1 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 CDF38243.1 - 1e-39 136.5 0.0 2.1e-39 135.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38243.1 - 8.6e-37 126.8 0.0 1.5e-36 126.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Arm PF00514.23 CDF38243.1 - 7.5e-05 22.6 0.2 0.41 10.8 0.0 3.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Kdo PF06293.14 CDF38243.1 - 0.0042 16.5 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_UBOX PF13445.6 CDF38243.1 - 0.71 9.9 3.3 0.29 11.2 0.2 1.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDF38243.1 - 1.4 9.2 3.8 1.1 9.4 0.7 2.3 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING CAP_N PF01213.19 CDF38244.1 - 8.8 5.7 8.3 12 5.2 8.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-NF-X1 PF01422.17 CDF38245.1 - 0.097 12.8 0.6 0.097 12.8 0.6 1.5 2 0 0 2 2 2 0 NF-X1 type zinc finger E1_4HB PF16191.5 CDF38246.1 - 0.0013 18.9 0.3 0.058 13.6 0.1 3.0 3 0 0 3 3 3 1 Ubiquitin-activating enzyme E1 four-helix bundle ThiF PF00899.21 CDF38246.1 - 0.041 13.2 0.0 0.083 12.2 0.0 1.6 1 1 0 1 1 1 0 ThiF family Anophelin PF10731.9 CDF38246.1 - 0.086 12.7 0.0 4.5 7.2 0.0 2.6 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito ABC1 PF03109.16 CDF38247.1 - 1.4e-33 115.5 0.0 2.6e-33 114.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family HNH_5 PF14279.6 CDF38248.1 - 1.7e-16 59.8 1.3 2.5e-16 59.2 1.3 1.3 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 CDF38248.1 - 1.1e-11 44.6 0.7 1.9e-11 44.0 0.7 1.3 1 0 0 1 1 1 1 HNH endonuclease HNH_4 PF13395.6 CDF38248.1 - 0.003 17.4 0.0 0.0051 16.7 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease zf-C2H2 PF00096.26 CDF38248.1 - 0.01 16.3 0.3 0.029 14.8 0.3 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CDF38248.1 - 0.051 13.6 0.4 0.091 12.8 0.4 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-CHCC PF10276.9 CDF38248.1 - 0.16 12.0 0.8 0.39 10.8 0.8 1.6 1 0 0 1 1 1 0 Zinc-finger domain zf-C2H2_4 PF13894.6 CDF38248.1 - 0.4 11.6 0.3 0.4 11.6 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger NB-ARC PF00931.22 CDF38251.1 - 1.1e-16 60.8 0.0 2.1e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CDF38251.1 - 0.00062 20.1 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Chromo PF00385.24 CDF38257.1 - 6.3e-05 22.8 0.0 0.00014 21.7 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Spuma_A9PTase PF03539.14 CDF38257.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RT_RNaseH PF17917.1 CDF38259.1 - 1.3e-33 115.4 0.0 2.2e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38259.1 - 6e-33 112.9 0.0 9.3e-33 112.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF38259.1 - 0.00056 19.5 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CagY_I PF14585.6 CDF38259.1 - 0.13 12.3 0.2 0.28 11.3 0.2 1.5 1 0 0 1 1 1 0 CagY type 1 repeat TB2_DP1_HVA22 PF03134.19 CDF38261.1 - 0.0018 18.2 0.4 0.0048 16.8 0.4 1.7 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Sulfotransfer_2 PF03567.14 CDF38265.1 - 2.4e-09 37.5 0.1 3.9e-09 36.8 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Treslin_N PF15292.6 CDF38265.1 - 0.084 11.2 0.0 0.095 11.0 0.0 1.1 1 0 0 1 1 1 0 Treslin N-terminus E1-E2_ATPase PF00122.20 CDF38268.1 - 3.5e-44 150.5 0.6 5.9e-44 149.8 0.6 1.4 1 0 0 1 1 1 1 E1-E2 ATPase TctB PF07331.11 CDF38268.1 - 0.12 12.6 12.4 0.16 12.2 1.8 2.5 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF3437 PF11919.8 CDF38268.1 - 0.42 10.6 1.3 9.7 6.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) rve PF00665.26 CDF38270.1 - 2e-12 47.3 0.1 6.1e-12 45.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CDF38270.1 - 0.0006 19.5 0.0 0.0016 18.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_3 PF13456.6 CDF38270.1 - 0.12 12.2 0.2 0.33 10.8 0.2 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like ABC_membrane PF00664.23 CDF38271.1 - 3.1e-66 223.8 34.5 1.1e-38 133.4 17.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDF38271.1 - 9.4e-49 165.4 0.1 1.5e-25 90.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDF38271.1 - 1.3e-09 37.9 7.6 0.0032 16.9 0.3 4.3 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDF38271.1 - 6.8e-08 33.1 0.4 0.00027 21.4 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CDF38271.1 - 2.3e-06 27.7 0.8 0.039 14.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDF38271.1 - 9.2e-06 25.8 0.8 0.01 15.9 0.0 2.8 2 0 0 2 2 2 2 Dynamin family AAA_29 PF13555.6 CDF38271.1 - 2.4e-05 24.0 0.2 0.16 11.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 CDF38271.1 - 4.7e-05 23.6 1.7 0.19 11.8 0.2 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain RsgA_GTPase PF03193.16 CDF38271.1 - 0.00037 20.5 2.7 0.23 11.4 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CDF38271.1 - 0.00086 19.6 1.0 0.75 10.1 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CDF38271.1 - 0.001 19.0 6.3 0.43 10.3 0.1 3.9 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDF38271.1 - 0.0013 18.5 1.6 1.7 8.3 0.1 3.0 2 1 0 2 2 2 2 AAA domain DUF815 PF05673.13 CDF38271.1 - 0.0019 17.4 0.5 0.64 9.1 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 CDF38271.1 - 0.0047 16.3 0.8 2 7.7 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family NB-ARC PF00931.22 CDF38271.1 - 0.0075 15.5 0.6 1.7 7.8 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_15 PF13175.6 CDF38271.1 - 0.011 15.5 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CDF38271.1 - 0.011 16.2 0.1 4.1 7.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDF38271.1 - 0.023 14.0 1.5 2.6 7.3 0.2 2.3 2 0 0 2 2 2 0 Zeta toxin DEAD PF00270.29 CDF38271.1 - 0.024 14.4 1.2 2.8 7.7 0.5 3.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 CDF38271.1 - 0.029 14.8 0.1 14 6.1 0.0 3.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDF38271.1 - 0.034 13.7 0.2 8.7 5.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 CDF38271.1 - 0.051 13.3 0.9 6.1 6.5 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 CDF38271.1 - 0.07 13.5 0.0 11 6.5 0.0 2.6 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 CDF38271.1 - 0.075 13.0 3.1 6.3 6.7 0.1 3.3 3 0 0 3 3 3 0 NACHT domain AIG1 PF04548.16 CDF38271.1 - 0.12 11.6 0.9 3.5 6.9 0.1 2.3 2 0 0 2 2 2 0 AIG1 family cobW PF02492.19 CDF38271.1 - 0.15 11.6 0.7 8.4 5.9 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CDF38271.1 - 0.19 12.0 0.2 32 4.8 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 CDF38271.1 - 0.21 11.6 0.5 1.9 8.5 0.1 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CDF38271.1 - 0.26 11.2 2.1 6.8 6.6 0.1 3.2 3 0 0 3 3 3 0 NTPase Rubis-subs-bind PF09273.11 CDF38272.1 - 6.2e-07 30.2 0.1 1.4e-06 29.0 0.1 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 CDF38272.1 - 5.4e-06 26.9 0.0 2.9e-05 24.5 0.0 2.3 1 1 0 1 1 1 1 SET domain PCI PF01399.27 CDF38273.1 - 3.2e-12 46.9 0.0 7.1e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_14 PF13428.6 CDF38273.1 - 0.1 13.5 1.0 8.1 7.6 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF3591 PF12157.8 CDF38274.1 - 1.2e-34 119.8 2.2 2.2e-34 118.9 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 CDF38274.1 - 8.3e-14 51.4 0.0 2.4e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 Bromodomain TBP-binding PF09247.11 CDF38274.1 - 1.2e-07 31.9 0.5 1.2e-07 31.9 0.5 2.8 2 0 0 2 2 2 1 TATA box-binding protein binding TPR_2 PF07719.17 CDF38276.1 - 4.1e-29 98.3 1.6 0.0023 17.9 0.0 11.0 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38276.1 - 1.1e-25 88.1 21.3 0.003 18.2 0.2 10.9 4 4 7 11 11 11 9 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38276.1 - 3.6e-21 75.4 0.0 2.1e-06 28.1 0.0 6.6 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF38276.1 - 4.6e-20 70.5 0.0 0.081 13.3 0.0 8.6 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38276.1 - 2.1e-18 66.7 21.1 0.0003 21.4 0.0 6.8 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDF38276.1 - 5e-18 63.7 0.0 0.32 11.3 0.0 9.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDF38276.1 - 2.9e-15 56.3 12.9 0.00017 21.8 0.0 6.6 4 2 2 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDF38276.1 - 5.8e-15 54.4 0.0 0.45 10.4 0.0 8.9 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF38276.1 - 4.8e-10 39.0 0.5 0.0064 16.2 0.0 6.9 6 2 2 8 8 8 2 TPR repeat TPR_6 PF13174.6 CDF38276.1 - 5.2e-10 39.3 1.2 13 6.7 0.0 8.1 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF38276.1 - 8.1e-09 34.9 3.6 1.6 9.0 0.0 7.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CDF38276.1 - 8.4e-08 32.0 2.7 7e-06 25.6 1.1 2.5 2 1 0 2 2 2 1 MalT-like TPR region TPR_9 PF13371.6 CDF38276.1 - 9.2e-08 32.1 11.7 1.2e-05 25.3 0.0 5.1 3 1 1 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF38276.1 - 2e-05 24.7 0.0 0.0063 16.7 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CDF38276.1 - 9.6e-05 21.7 7.2 0.12 11.6 3.9 3.9 1 1 0 3 3 3 1 Tetratricopeptide repeat HAT PF02184.16 CDF38276.1 - 0.0019 18.1 7.4 2.4 8.2 0.0 4.6 4 0 0 4 4 4 1 HAT (Half-A-TPR) repeat MIT PF04212.18 CDF38276.1 - 0.0033 17.4 0.3 9.7 6.3 0.0 4.6 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 CDF38276.1 - 0.0069 16.2 9.1 4.4 7.3 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat MLTD_N PF06474.12 CDF38276.1 - 0.031 14.4 0.2 0.088 13.0 0.2 1.7 1 0 0 1 1 1 0 MltD lipid attachment motif TPR_21 PF09976.9 CDF38276.1 - 0.044 13.5 3.7 5.5 6.6 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain HemY_N PF07219.13 CDF38276.1 - 0.16 12.2 8.1 8.5 6.6 0.0 4.3 3 2 0 4 4 4 0 HemY protein N-terminus FAT PF02259.23 CDF38276.1 - 2.3 7.3 4.5 8.3 5.5 0.1 3.3 1 1 3 4 4 4 0 FAT domain RRM_1 PF00076.22 CDF38278.1 - 4.4e-14 52.0 0.0 8.7e-14 51.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4873 PF16170.5 CDF38278.1 - 0.041 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4873) DUF4078 PF13300.6 CDF38278.1 - 0.11 12.9 2.9 5.2 7.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4078) CHCH PF06747.13 CDF38279.1 - 5.7e-08 32.7 2.5 7.4e-08 32.3 2.5 1.2 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 CDF38279.1 - 3.1e-05 24.1 0.4 4e-05 23.8 0.4 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Cmc1 PF08583.10 CDF38279.1 - 0.01 15.8 1.3 0.021 14.9 1.3 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 CDF38279.1 - 0.015 15.3 0.4 0.02 14.9 0.4 1.2 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Fibrillarin PF01269.17 CDF38280.1 - 1e-102 342.0 0.0 1.2e-102 341.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CDF38280.1 - 0.0001 22.1 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 CDF38280.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F RETICULATA-like PF11891.8 CDF38281.1 - 8.9e-41 139.7 0.0 1.3e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Protein RETICULATA-related RVT_3 PF13456.6 CDF38282.1 - 0.066 13.0 0.1 0.23 11.2 0.1 1.8 1 1 0 1 1 1 0 Reverse transcriptase-like TPT PF03151.16 CDF38284.1 - 2.8e-21 76.1 8.2 3.5e-21 75.8 8.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDF38284.1 - 0.00028 21.1 25.3 0.015 15.5 11.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CDF38284.1 - 0.0027 17.0 15.4 0.0073 15.5 15.4 1.8 1 1 0 1 1 1 1 UAA transporter family Mito_carr PF00153.27 CDF38285.1 - 1.7e-61 204.1 3.7 1.4e-20 73.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 CDF38287.1 - 1.1e-39 134.0 0.0 3.6e-19 68.4 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CDF38287.1 - 0.00015 21.8 0.0 0.12 12.5 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 CDF38287.1 - 0.014 15.5 0.0 0.88 9.7 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif Nup35_RRM_2 PF14605.6 CDF38287.1 - 0.035 14.1 0.0 1.7 8.7 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF3932 PF13068.6 CDF38287.1 - 0.07 13.4 0.0 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3932) Limkain-b1 PF11608.8 CDF38287.1 - 0.084 13.0 0.2 7.4 6.7 0.0 2.4 2 1 0 2 2 2 0 Limkain b1 NLRC4_HD2 PF17776.1 CDF38288.1 - 0.045 14.3 5.2 2.5 8.7 0.0 3.4 2 1 1 3 3 3 0 NLRC4 helical domain HD2 DUF924 PF06041.11 CDF38289.1 - 2.5e-48 164.6 0.0 3e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) DUF4087 PF13316.6 CDF38291.1 - 0.17 12.4 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4087) NOB1_Zn_bind PF08772.11 CDF38293.1 - 2.6e-23 82.0 1.0 5.1e-23 81.0 1.0 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 CDF38293.1 - 1.7e-19 70.1 4.2 1.7e-18 66.9 0.1 3.2 3 0 0 3 3 3 1 PIN domain of ribonuclease Zn-ribbon_8 PF09723.10 CDF38293.1 - 0.52 10.5 1.8 0.97 9.6 1.8 1.5 1 0 0 1 1 1 0 Zinc ribbon domain RRP7 PF12923.7 CDF38293.1 - 0.71 10.0 10.6 0.092 12.9 5.4 2.1 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Nudix_N_2 PF14803.6 CDF38293.1 - 3.9 7.5 6.0 1.1 9.2 0.3 2.8 3 0 0 3 3 3 0 Nudix N-terminal UQ_con PF00179.26 CDF38294.1 - 2.5e-65 218.4 0.0 2.4e-33 114.7 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme UEV PF05743.13 CDF38294.1 - 2.8e-05 24.0 0.0 0.00019 21.3 0.0 2.1 2 0 0 2 2 2 1 UEV domain Prok-E2_B PF14461.6 CDF38294.1 - 0.031 14.0 0.0 0.34 10.6 0.0 2.2 2 1 0 2 2 2 0 Prokaryotic E2 family B RWD PF05773.22 CDF38294.1 - 0.038 14.3 0.0 7.2 6.9 0.0 2.5 2 0 0 2 2 2 0 RWD domain Thioredoxin PF00085.20 CDF38295.1 - 1.3e-23 82.9 0.0 1.9e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Pho88 PF10032.9 CDF38295.1 - 4.8e-07 29.2 0.0 6.5e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Phosphate transport (Pho88) OST3_OST6 PF04756.13 CDF38295.1 - 2.6e-05 23.7 0.0 4.9e-05 22.8 0.0 1.4 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CDF38295.1 - 3.4e-05 24.2 0.0 0.00059 20.3 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDF38295.1 - 0.00013 22.2 0.0 0.00042 20.6 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 CDF38295.1 - 0.00075 19.3 0.0 0.002 17.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin AhpC-TSA PF00578.21 CDF38295.1 - 0.0066 16.4 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 CDF38295.1 - 0.036 14.2 0.0 0.15 12.2 0.1 2.0 2 1 0 2 2 2 0 Thioredoxin-like TraF PF13728.6 CDF38295.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Ribul_P_3_epim PF00834.19 CDF38296.1 - 3.1e-66 222.6 0.0 6.5e-33 113.8 0.0 2.0 2 0 0 2 2 2 2 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 CDF38296.1 - 0.019 14.8 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain IMPDH PF00478.25 CDF38296.1 - 0.022 13.8 0.3 0.04 12.9 0.3 1.3 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CDF38296.1 - 0.069 12.6 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein OMPdecase PF00215.24 CDF38296.1 - 0.11 12.1 0.0 0.27 10.8 0.0 1.7 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family SpoU_methylase PF00588.19 CDF38297.1 - 1.5e-22 80.3 0.0 2.2e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family FA_desaturase PF00487.24 CDF38298.1 - 5.7e-23 82.0 7.7 8.8e-22 78.2 7.7 2.0 1 1 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 CDF38298.1 - 1.1e-07 31.2 0.9 2.1e-07 30.3 0.9 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) ABC1 PF03109.16 CDF38299.1 - 3.3e-32 111.2 0.0 5.5e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CDF38299.1 - 5.5e-06 26.5 1.3 0.00025 21.1 0.3 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 CDF38299.1 - 0.00014 21.3 0.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain WaaY PF06176.11 CDF38299.1 - 0.00095 18.8 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Polyketide_cyc2 PF10604.9 CDF38300.1 - 0.088 13.1 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport NUDIX PF00293.28 CDF38302.1 - 4.9e-18 65.4 0.2 7.5e-18 64.8 0.2 1.3 1 0 0 1 1 1 1 NUDIX domain PCI PF01399.27 CDF38303.1 - 1e-11 45.2 0.1 3.3e-11 43.6 0.1 1.9 1 0 0 1 1 1 1 PCI domain eIF3m_C_helix PF18005.1 CDF38303.1 - 7.1e-05 22.4 0.0 0.0002 21.0 0.0 1.8 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix Arnt_C PF18583.1 CDF38303.1 - 0.048 13.3 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 Aminoarabinose transferase C-terminal domain Rubredoxin PF00301.20 CDF38304.1 - 0.00036 20.5 1.2 0.00063 19.7 1.2 1.4 1 0 0 1 1 1 1 Rubredoxin DUF2462 PF09495.10 CDF38305.1 - 2.4e-10 41.0 10.1 2.4e-10 41.0 10.1 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) UBN_AB PF14075.6 CDF38305.1 - 0.026 14.2 0.7 0.03 14.0 0.7 1.1 1 0 0 1 1 1 0 Ubinuclein conserved middle domain RT_RNaseH PF17917.1 CDF38306.1 - 3.6e-33 114.0 0.0 1e-32 112.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38306.1 - 7.3e-32 109.4 0.0 1.6e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF38306.1 - 2.4e-20 72.9 0.0 5.3e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF38306.1 - 2.6e-12 46.7 0.0 5.3e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 CDF38306.1 - 0.00098 18.9 0.4 0.0075 16.0 0.0 2.8 3 0 0 3 3 3 1 Integrase core domain RVT_1 PF00078.27 CDF38306.1 - 0.0024 17.4 0.0 0.0067 16.0 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF38306.1 - 0.065 13.5 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 H2C2 zinc finger APOBEC2 PF18772.1 CDF38307.1 - 0.079 13.0 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 APOBEC2 HTH_Tnp_Tc3_1 PF11427.8 CDF38310.1 - 2.6e-10 40.0 0.0 5.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF38310.1 - 3.2e-07 30.0 0.0 7.4e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DDE_3 PF13358.6 CDF38310.1 - 5.7e-05 22.9 0.0 0.00029 20.6 0.0 2.0 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_32 PF13565.6 CDF38310.1 - 0.072 13.7 2.5 0.45 11.2 1.9 2.4 1 1 1 2 2 2 0 Homeodomain-like domain TrmB PF01978.19 CDF38310.1 - 0.09 12.7 0.2 0.73 9.8 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB dCMP_cyt_deam_1 PF00383.23 CDF38311.1 - 6.9e-15 54.8 0.0 9e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CDF38311.1 - 2.4e-11 44.0 0.2 1.4e-09 38.3 0.1 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Ribosomal_L16 PF00252.18 CDF38312.1 - 9.7e-22 77.4 0.1 1.2e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Pro_isomerase PF00160.21 CDF38313.1 - 1.6e-40 139.0 0.0 2.1e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MMR_HSR1 PF01926.23 CDF38314.1 - 2.6e-18 66.2 0.0 2.2e-17 63.2 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF38314.1 - 1e-08 34.9 0.0 6.1e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDF38314.1 - 1.9e-05 24.6 0.0 0.21 11.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 CDF38314.1 - 5.2e-05 22.7 0.0 7.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 CDF38314.1 - 0.0032 17.5 0.1 0.086 12.9 0.0 2.4 1 1 1 2 2 2 1 Dynamin family AAA_16 PF13191.6 CDF38314.1 - 0.044 14.2 0.0 0.12 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 CDF38314.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDF38314.1 - 0.17 11.5 0.0 1.2 8.7 0.0 2.3 2 1 0 2 2 2 0 Ras family UPRTase PF14681.6 CDF38315.1 - 4.1e-64 215.8 0.0 4.6e-64 215.7 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CDF38315.1 - 1.3e-05 24.8 0.1 4.6e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain TMP-TENI PF02581.17 CDF38315.1 - 0.022 14.1 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase LRR_6 PF13516.6 CDF38317.1 - 5.8e-06 25.9 9.9 0.037 14.1 0.1 6.4 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 CDF38317.1 - 0.0058 17.0 0.0 9.8 6.8 0.0 3.6 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) TP_methylase PF00590.20 CDF38318.1 - 4.7e-43 147.6 0.3 5.8e-43 147.3 0.3 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Epimerase PF01370.21 CDF38319.1 - 1.1e-30 106.8 0.2 1.8e-30 106.2 0.1 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDF38319.1 - 1.1e-21 77.6 0.0 1.6e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDF38319.1 - 9.9e-20 70.7 0.0 1.3e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDF38319.1 - 2.8e-15 56.2 0.5 3e-10 39.7 0.2 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CDF38319.1 - 1.1e-11 44.9 0.7 1.7e-11 44.4 0.7 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CDF38319.1 - 7.8e-08 31.8 0.4 1.3e-07 31.1 0.4 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CDF38319.1 - 0.00012 22.0 2.7 0.00059 19.8 2.2 2.2 2 1 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 CDF38319.1 - 0.00015 21.0 3.6 0.0024 17.1 3.6 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CDF38319.1 - 0.0027 17.2 0.1 0.01 15.3 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 CDF38319.1 - 0.0027 17.3 0.0 0.0082 15.7 0.0 1.7 2 0 0 2 2 2 1 NmrA-like family XdhC_C PF13478.6 CDF38319.1 - 0.14 12.7 0.3 0.37 11.3 0.3 1.7 1 1 0 1 1 1 0 XdhC Rossmann domain Pkinase PF00069.25 CDF38320.1 - 4.1e-61 206.7 0.0 5.8e-61 206.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38320.1 - 2.8e-24 85.8 0.0 4e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TetR_C_11 PF16859.5 CDF38320.1 - 0.13 12.6 0.0 2.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Acyl-CoA_dh_2 PF08028.11 CDF38320.1 - 0.26 11.6 1.2 0.68 10.2 1.2 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain DUF2358 PF10184.9 CDF38321.1 - 2e-24 86.1 0.0 2.7e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) SnoaL_2 PF12680.7 CDF38321.1 - 0.095 13.3 0.0 0.22 12.2 0.0 1.7 1 0 0 1 1 1 0 SnoaL-like domain UbiA PF01040.18 CDF38322.1 - 5.9e-37 127.3 19.4 7.5e-37 127.0 19.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family REJ PF02010.15 CDF38325.1 - 1.9e-16 59.9 0.0 5.1e-16 58.5 0.0 1.7 1 1 0 1 1 1 1 REJ domain DX PF01666.17 CDF38326.1 - 5.8 7.5 34.0 4.4 7.8 0.5 5.5 3 2 2 5 5 5 0 DX module Amino_oxidase PF01593.24 CDF38327.1 - 4.6e-54 184.4 0.0 5.4e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF38327.1 - 8.5e-09 35.5 0.0 1.9e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF38327.1 - 0.0052 16.4 0.1 0.016 14.8 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Mob_synth_C PF06463.13 CDF38328.1 - 4.1e-38 130.2 0.0 6.1e-38 129.6 0.0 1.2 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 CDF38328.1 - 9.8e-22 78.1 0.0 1.6e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDF38328.1 - 0.039 14.2 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDF38328.1 - 0.041 14.0 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain NAD_binding_10 PF13460.6 CDF38331.1 - 1e-05 25.5 0.0 1.1e-05 25.4 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding RVT_1 PF00078.27 CDF38334.1 - 0.00016 21.3 0.0 0.0002 21.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Nucleoporin_C PF03177.14 CDF38337.1 - 8e-10 38.1 0.0 8.7e-06 24.8 0.0 2.9 3 1 0 3 3 3 2 Non-repetitive/WGA-negative nucleoporin C-terminal DUF3100 PF11299.8 CDF38339.1 - 0.099 12.0 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3100) COPI_C PF06957.11 CDF38342.1 - 0.026 13.3 0.8 0.034 12.9 0.8 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Hist_deacetyl PF00850.19 CDF38343.1 - 2.2e-60 204.8 0.0 3.1e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain MIP PF00230.20 CDF38343.1 - 8.6e-44 149.9 7.1 1.3e-43 149.4 7.1 1.2 1 0 0 1 1 1 1 Major intrinsic protein DUF4223 PF13978.6 CDF38345.1 - 0.14 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) RrnaAD PF00398.20 CDF38346.1 - 1.6e-38 132.3 0.1 2.3e-38 131.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Thioredoxin PF00085.20 CDF38348.1 - 1.7e-05 24.7 0.0 9.5e-05 22.3 0.0 2.2 3 0 0 3 3 3 1 Thioredoxin BRCT PF00533.26 CDF38349.1 - 4.2e-05 23.8 0.0 0.0041 17.5 0.0 2.8 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 CDF38349.1 - 0.00073 19.4 0.0 0.0019 18.1 0.0 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Josephin PF02099.17 CDF38350.1 - 8.8e-07 29.2 0.0 1.2e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Josephin DNA_pol_phi PF04931.13 CDF38350.1 - 0.072 11.2 8.6 0.092 10.8 8.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 CDF38350.1 - 0.91 8.6 9.8 1.2 8.2 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) APAF1_C PF17908.1 CDF38352.1 - 0.15 12.1 0.0 0.31 11.0 0.0 1.5 2 0 0 2 2 2 0 APAF-1 helical domain WD40 PF00400.32 CDF38354.1 - 2.8e-80 262.1 63.9 2.5e-09 37.6 0.5 14.2 14 0 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38354.1 - 5.9e-16 58.6 21.9 0.14 12.5 0.0 10.4 2 2 9 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF38354.1 - 2.2e-06 27.2 0.0 0.64 9.3 0.0 5.2 5 2 1 6 6 6 2 WD40-like domain PQQ PF01011.21 CDF38354.1 - 0.0056 16.6 1.2 96 3.2 0.0 6.0 6 0 0 6 6 6 0 PQQ enzyme repeat PQQ_3 PF13570.6 CDF38354.1 - 0.018 15.5 33.5 14 6.3 0.0 10.9 9 5 3 12 12 12 0 PQQ-like domain Ge1_WD40 PF16529.5 CDF38354.1 - 0.023 13.7 8.3 20 4.0 0.0 6.9 4 4 2 9 9 9 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4402 PF14352.6 CDF38354.1 - 0.029 15.0 20.3 0.11 13.2 0.0 5.3 3 1 2 6 6 6 0 Domain of unknown function (DUF4402) DUF5018 PF16410.5 CDF38354.1 - 0.1 11.3 2.6 0.25 10.0 0.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5018) Nup160 PF11715.8 CDF38354.1 - 0.95 8.0 19.4 1.8 7.1 0.2 7.1 4 1 5 10 10 10 0 Nucleoporin Nup120/160 DUF5136 PF17199.4 CDF38355.1 - 0.098 12.4 1.6 0.17 11.6 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF5136) Pkinase PF00069.25 CDF38361.1 - 6.4e-30 104.4 0.0 9e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38361.1 - 7.8e-13 48.3 0.0 1.1e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDF38361.1 - 0.00021 21.3 0.1 0.00096 19.1 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family SnoaL_2 PF12680.7 CDF38362.1 - 4.9e-07 30.3 0.0 7.1e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SH3_13 PF18335.1 CDF38363.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain YtxH PF12732.7 CDF38363.1 - 0.17 12.5 19.2 3.7 8.2 8.6 3.2 1 1 1 2 2 2 0 YtxH-like protein Golgin_A5 PF09787.9 CDF38363.1 - 0.19 11.2 11.0 0.26 10.7 11.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF883 PF05957.13 CDF38363.1 - 0.51 11.0 42.0 20 5.8 18.4 3.7 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF2554 PF10829.8 CDF38363.1 - 3.4 8.1 14.1 4.1 7.9 1.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2554) PCI PF01399.27 CDF38365.1 - 2e-17 63.6 0.8 5.4e-17 62.2 0.4 2.0 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 CDF38365.1 - 1.1e-12 47.9 0.6 2.9e-12 46.5 0.6 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain GP3_package PF16677.5 CDF38365.1 - 0.077 13.1 0.1 0.42 10.8 0.1 2.3 2 0 0 2 2 2 0 DNA-packaging protein gp3 JAB PF01398.21 CDF38367.1 - 3.4e-15 56.1 1.0 1.1e-14 54.3 1.0 1.8 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CTK3_C PF12350.8 CDF38367.1 - 0.088 13.0 0.7 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus Retrotran_gag_2 PF14223.6 CDF38368.1 - 5.5e-33 113.6 0.0 1.2e-32 112.5 0.0 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF38368.1 - 5.5e-21 75.0 0.1 2.6e-20 72.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF38368.1 - 1.4e-07 31.3 0.0 7e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF38368.1 - 0.002 17.8 0.0 0.0048 16.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain CENP-C_mid PF15620.6 CDF38368.1 - 0.025 14.5 0.6 0.059 13.3 0.1 1.7 2 0 0 2 2 2 0 Centromere assembly component CENP-C middle DNMT3B-binding region zf-CCHC_4 PF14392.6 CDF38368.1 - 0.092 12.5 1.5 0.28 11.0 1.5 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF38368.1 - 0.34 11.1 4.0 0.69 10.1 4.0 1.5 1 0 0 1 1 1 0 Zinc knuckle Retrotran_gag_2 PF14223.6 CDF38369.1 - 3.8e-33 114.1 0.0 8.5e-33 112.9 0.0 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF38369.1 - 5.3e-21 75.0 0.2 2.6e-20 72.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF38369.1 - 1e-07 31.7 0.0 5.2e-07 29.4 0.0 2.2 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF38369.1 - 0.0021 17.8 0.0 0.0049 16.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain CENP-C_mid PF15620.6 CDF38369.1 - 0.034 14.1 1.0 0.06 13.3 0.2 1.7 2 0 0 2 2 2 0 Centromere assembly component CENP-C middle DNMT3B-binding region zf-CCHC_4 PF14392.6 CDF38369.1 - 0.095 12.4 1.5 0.28 11.0 1.5 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF38369.1 - 0.32 11.2 4.0 0.7 10.1 4.0 1.6 1 0 0 1 1 1 0 Zinc knuckle CCT PF06203.14 CDF38371.1 - 7e-10 38.8 7.2 7e-10 38.8 7.2 2.0 3 0 0 3 3 3 1 CCT motif DDE_3 PF13358.6 CDF38371.1 - 0.091 12.5 1.0 0.12 12.1 1.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease CCT_2 PF09425.10 CDF38371.1 - 0.43 10.5 9.5 0.1 12.5 5.0 2.1 2 0 0 2 2 2 0 Divergent CCT motif WD40 PF00400.32 CDF38372.1 - 1.8e-38 129.8 28.0 1.1e-06 29.2 0.4 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat TIR_2 PF13676.6 CDF38372.1 - 9.4e-17 61.7 0.0 2e-15 57.5 0.0 3.1 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF38372.1 - 2.8e-16 59.5 0.0 7.9e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF38372.1 - 2.4e-08 34.1 8.5 0.0097 16.2 0.1 5.6 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.20 CDF38372.1 - 4.5e-08 33.1 0.0 1.2e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 TIR domain Nup160 PF11715.8 CDF38372.1 - 9.9e-06 24.5 5.8 8.3 4.9 0.0 6.6 5 1 2 7 7 7 2 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF38372.1 - 0.0049 17.2 0.0 0.015 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIR-like PF10137.9 CDF38372.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Mito_carr PF00153.27 CDF38376.1 - 1.1e-24 86.1 0.1 2.9e-10 39.9 0.0 3.1 2 1 0 2 2 2 2 Mitochondrial carrier protein TPR_2 PF07719.17 CDF38377.1 - 4.9e-23 79.3 12.0 0.003 17.5 0.1 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDF38377.1 - 1.7e-17 62.4 3.8 0.18 12.3 0.0 7.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38377.1 - 4.3e-17 61.3 11.7 0.0022 18.7 0.0 8.4 4 3 5 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38377.1 - 8.6e-13 48.6 1.3 0.012 16.2 0.0 5.3 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDF38377.1 - 9.7e-13 47.4 1.5 0.11 12.3 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF38377.1 - 6.1e-10 39.3 13.4 0.23 11.8 0.0 7.3 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDF38377.1 - 1.4e-09 37.4 0.1 3.6 8.0 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38377.1 - 5.9e-08 33.2 14.7 0.00016 22.3 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDF38377.1 - 4e-06 26.2 11.9 0.0033 16.7 4.2 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF38377.1 - 5.1e-06 26.1 0.0 8.4 6.2 0.0 5.8 5 1 1 6 6 6 1 TPR repeat Fis1_TPR_C PF14853.6 CDF38377.1 - 7.1e-06 26.0 0.6 7.2 6.8 0.0 5.3 6 0 0 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 CDF38377.1 - 6.4e-05 22.7 0.5 7.8 6.8 0.0 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat Suf PF05843.14 CDF38377.1 - 0.0064 16.5 1.1 0.54 10.2 0.2 3.0 1 1 2 3 3 3 2 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 CDF38377.1 - 0.0085 16.1 6.9 5.7 7.0 0.0 4.5 4 1 1 5 5 5 1 Mad3/BUB1 homology region 1 ANAPC3 PF12895.7 CDF38377.1 - 0.032 14.5 3.7 0.78 10.0 0.5 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 CDF38377.1 - 0.17 10.9 0.2 1.7 7.5 0.1 2.4 2 1 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 CDF38377.1 - 0.19 11.7 9.8 17 5.5 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat Sel1 PF08238.12 CDF38377.1 - 0.34 11.7 2.8 34 5.3 0.1 4.2 4 0 0 4 4 4 0 Sel1 repeat TPR_6 PF13174.6 CDF38377.1 - 1.8 9.3 12.2 28 5.6 0.0 6.0 8 0 0 8 8 6 0 Tetratricopeptide repeat SNF2_N PF00176.23 CDF38378.1 - 2.4e-07 29.8 0.0 4.9e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_23 PF13476.6 CDF38379.1 - 8.3e-19 68.9 30.7 8.3e-19 68.9 30.7 7.6 2 2 1 3 3 3 1 AAA domain AAA_15 PF13175.6 CDF38379.1 - 2.1e-16 60.6 8.2 3.6e-06 26.9 0.0 4.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CDF38379.1 - 1.4e-09 38.2 0.5 0.0017 18.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF38379.1 - 9.2e-08 31.8 27.6 4.2e-07 29.6 0.0 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CDF38379.1 - 2.2e-06 27.8 0.3 7.3e-06 26.1 0.0 2.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CDF38379.1 - 9.6e-05 22.0 0.0 0.00022 20.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CDF38379.1 - 0.0048 17.4 16.2 0.0081 16.7 0.0 5.1 3 2 0 3 3 3 1 ABC transporter AAA_27 PF13514.6 CDF38379.1 - 0.019 14.6 0.0 0.019 14.6 0.0 4.1 4 0 0 4 4 4 0 AAA domain DUF3782 PF12644.7 CDF38379.1 - 0.97 9.6 9.4 6.4 7.0 0.0 5.6 5 0 0 5 5 5 0 Protein of unknown function (DUF3782) Katanin_con80 PF13925.6 CDF38379.1 - 6 6.9 15.8 0.15 12.0 1.4 4.6 3 2 2 5 5 5 0 con80 domain of Katanin NrsF PF06532.11 CDF38381.1 - 0.02 14.6 0.8 0.032 14.0 0.8 1.2 1 0 0 1 1 1 0 Negative regulator of sigma F DUF4079 PF13301.6 CDF38381.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) PIF1 PF05970.14 CDF38382.1 - 1.2e-80 271.5 0.0 1.9e-80 270.8 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF38382.1 - 8e-30 104.5 0.6 1.8e-16 60.9 0.0 2.7 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF38382.1 - 6.1e-08 32.6 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF38382.1 - 0.06 13.0 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF38382.1 - 0.18 9.7 0.0 0.28 9.1 0.0 1.2 1 0 0 1 1 1 0 Helicase UCR_Fe-S_N PF10399.9 CDF38382.1 - 0.21 10.9 2.1 0.55 9.6 2.1 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal UvrD_C_2 PF13538.6 CDF38383.1 - 0.0039 17.0 0.7 0.038 13.8 0.7 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 CDF38383.1 - 0.017 13.1 0.0 0.018 13.0 0.0 1.0 1 0 0 1 1 1 0 Helicase RT_RNaseH PF17917.1 CDF38384.1 - 6.3e-32 110.0 0.1 2.7e-30 104.7 0.0 2.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38384.1 - 3.4e-30 104.0 0.0 1.1e-28 99.2 0.0 2.4 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF38384.1 - 8.1e-13 48.3 0.0 1.6e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF38384.1 - 1.3e-11 44.7 0.0 2.8e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CDF38384.1 - 2.5e-07 30.4 0.0 4.5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF38384.1 - 0.026 14.7 0.0 0.054 13.7 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger rve_3 PF13683.6 CDF38384.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Glyco_hydro_63 PF03200.16 CDF38387.1 - 5.4e-10 38.6 6.4 4e-07 29.2 0.2 3.2 2 1 1 3 3 3 3 Glycosyl hydrolase family 63 C-terminal domain Trehalase PF01204.18 CDF38387.1 - 6.6e-07 28.5 0.1 9.2e-07 28.0 0.1 1.1 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid6H PF17389.2 CDF38387.1 - 0.0035 16.7 0.2 0.0089 15.3 0.2 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain RT_RNaseH PF17917.1 CDF38390.1 - 1.2e-29 102.7 0.0 6.8e-29 100.2 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38390.1 - 5.8e-24 84.0 0.0 2.1e-23 82.2 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF38390.1 - 4.3e-19 68.9 0.0 9.8e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF38390.1 - 4.2e-12 46.0 2.0 4.2e-12 46.0 2.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 CDF38390.1 - 9.5e-05 22.1 0.1 0.0059 16.4 0.0 3.2 3 0 0 3 3 3 1 Integrase core domain PAS_8 PF13188.7 CDF38390.1 - 0.17 12.0 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 PAS domain Flavin_Reduct PF01613.18 CDF38391.1 - 2.9e-09 37.1 3.8 1e-08 35.4 1.7 2.6 2 1 0 2 2 2 1 Flavin reductase like domain DUF1500 PF07389.12 CDF38393.1 - 0.12 12.5 0.1 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1500) Rft-1 PF04506.13 CDF38394.1 - 6.6e-62 209.9 17.5 8.6e-62 209.5 17.5 1.1 1 0 0 1 1 1 1 Rft protein DUF3681 PF12442.8 CDF38394.1 - 2.9 8.4 10.5 6 7.4 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3681) Aldedh PF00171.22 CDF38395.1 - 3.9e-82 276.2 0.0 4.8e-82 275.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1931 PF09123.11 CDF38395.1 - 0.15 12.2 0.0 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1931) Reovirus_Mu2 PF07781.11 CDF38395.1 - 0.17 10.2 0.1 0.47 8.7 0.1 1.6 2 0 0 2 2 2 0 Reovirus minor core protein Mu-2 DVL PF08137.12 CDF38396.1 - 5.4 7.0 6.3 2.1 8.3 3.0 1.9 2 0 0 2 2 2 0 DVL family ILVD_EDD PF00920.21 CDF38397.1 - 2.4e-198 660.0 4.6 2.7e-198 659.8 4.6 1.0 1 0 0 1 1 1 1 Dehydratase family AAA PF00004.29 CDF38399.1 - 1e-16 61.6 0.0 2e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF38399.1 - 0.00033 21.1 0.0 0.00071 20.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CDF38399.1 - 0.00092 19.2 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CDF38399.1 - 0.013 15.8 0.0 0.041 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CDF38399.1 - 0.027 14.3 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF38399.1 - 0.036 13.6 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CDF38399.1 - 0.056 14.0 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Methyltransf_12 PF08242.12 CDF38399.1 - 0.089 13.5 0.0 0.21 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TMPIT PF07851.13 CDF38400.1 - 4.5e-74 249.6 9.2 2.1e-73 247.4 9.2 1.8 1 1 0 1 1 1 1 TMPIT-like protein Ribosomal_L35p PF01632.19 CDF38401.1 - 1.3e-13 51.2 7.4 2.2e-13 50.5 7.4 1.4 1 1 0 1 1 1 1 Ribosomal protein L35 Ribosomal_L24e PF01246.20 CDF38402.1 - 7e-32 109.5 2.8 1.2e-31 108.7 2.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L24e DUF2175 PF09943.9 CDF38402.1 - 1.1 9.6 3.8 0.92 9.8 0.3 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) COG7 PF10191.9 CDF38404.1 - 9.9e-33 113.4 0.0 1.3e-17 63.4 0.0 2.2 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) RINT1_TIP1 PF04437.13 CDF38404.1 - 0.00041 19.4 0.0 0.24 10.2 0.0 3.0 3 0 0 3 3 3 2 RINT-1 / TIP-1 family ATPgrasp_N PF18130.1 CDF38404.1 - 0.14 12.8 0.1 0.44 11.1 0.1 1.8 1 0 0 1 1 1 0 ATP-grasp N-terminal domain adh_short PF00106.25 CDF38406.1 - 1.6e-26 92.9 0.0 3.3e-26 92.0 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF38406.1 - 9.1e-20 71.2 0.0 5.3e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF38406.1 - 1.5e-05 25.0 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 KR domain UBX PF00789.20 CDF38410.1 - 3.8e-10 39.8 0.0 9.1e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 UBX domain E1-E2_ATPase PF00122.20 CDF38411.1 - 4.1e-09 36.2 0.0 1.6e-08 34.3 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CDF38411.1 - 2e-08 34.8 1.2 4.2e-05 23.9 1.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF38411.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase HemY_N PF07219.13 CDF38411.1 - 9.9 6.4 8.6 13 6.0 0.7 2.9 1 1 1 2 2 2 0 HemY protein N-terminus Ecm29 PF13001.7 CDF38415.1 - 2.6e-27 95.7 0.0 8.3e-25 87.4 0.0 3.0 3 0 0 3 3 3 2 Proteasome stabiliser HEAT PF02985.22 CDF38415.1 - 2.2e-07 30.5 17.7 2.5 8.6 0.0 11.3 11 0 0 11 11 11 2 HEAT repeat Vac14_Fab1_bd PF12755.7 CDF38415.1 - 3.6e-06 27.5 0.0 5.7 7.6 0.0 5.6 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 CDF38415.1 - 4.5e-05 23.7 25.3 0.013 15.8 0.1 9.9 9 3 1 10 10 10 1 HEAT repeats RIX1 PF08167.12 CDF38415.1 - 0.029 14.1 1.4 5.6 6.7 0.0 3.4 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis Methyltransf_19 PF04672.12 CDF38415.1 - 0.063 12.8 0.1 0.19 11.2 0.0 1.8 2 0 0 2 2 2 0 S-adenosyl methyltransferase MMS19_C PF12460.8 CDF38415.1 - 0.12 11.5 0.5 0.71 8.9 0.0 2.5 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 CDF38415.1 - 5.5 7.6 24.4 18 6.0 0.1 8.8 11 0 0 11 11 11 0 HEAT-like repeat HEAT_PBS PF03130.16 CDF38415.1 - 5.8 7.9 6.3 12 6.9 0.8 4.3 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Lectin_leg-like PF03388.13 CDF38417.1 - 6.5e-26 91.1 0.0 1e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 CDF38417.1 - 1.6e-08 34.8 0.1 3.1e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial lectin Roughex PF06020.11 CDF38417.1 - 0.00048 19.3 2.1 0.00074 18.7 2.1 1.2 1 0 0 1 1 1 1 Drosophila roughex protein DUF4201 PF13870.6 CDF38417.1 - 0.019 14.7 1.5 0.019 14.7 1.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Laminin_II PF06009.12 CDF38417.1 - 0.11 12.6 1.1 0.2 11.7 1.1 1.4 1 0 0 1 1 1 0 Laminin Domain II Prominin PF05478.11 CDF38417.1 - 0.25 9.3 0.6 0.43 8.5 0.6 1.3 1 0 0 1 1 1 0 Prominin Spt20 PF12090.8 CDF38417.1 - 1.9 8.0 9.5 3 7.4 9.5 1.2 1 0 0 1 1 1 0 Spt20 family Pro_isomerase PF00160.21 CDF38419.1 - 1.8e-23 83.6 0.0 2.2e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sen15 PF09631.10 CDF38422.1 - 1e-07 32.2 0.0 1.3e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Sen15 protein SH3-RhoG_link PF16609.5 CDF38422.1 - 0.036 13.8 0.2 0.045 13.5 0.2 1.1 1 0 0 1 1 1 0 SH3-RhoGEF linking unstructured region SPX PF03105.19 CDF38424.1 - 1.5 8.6 8.0 2 8.2 8.0 1.3 1 0 0 1 1 1 0 SPX domain JAB PF01398.21 CDF38425.1 - 2.5e-33 114.5 0.1 4.9e-33 113.6 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDF38425.1 - 1.7e-11 44.6 0.5 3.3e-11 43.6 0.5 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 CDF38425.1 - 1.1e-05 25.1 0.0 2.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 CDF38425.1 - 0.088 12.9 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) CbiA PF01656.23 CDF38425.1 - 0.13 12.3 0.0 0.14 12.2 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Enkurin PF13864.6 CDF38425.1 - 0.18 12.2 1.6 3 8.3 1.9 2.3 1 1 1 2 2 2 0 Calmodulin-binding GDPD PF03009.17 CDF38426.1 - 6e-23 81.9 0.0 7.7e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family E1-E2_ATPase PF00122.20 CDF38427.1 - 2.1e-44 151.2 2.9 2.1e-44 151.2 2.9 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDF38427.1 - 7e-43 146.4 0.5 7e-43 146.4 0.5 2.8 3 1 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 CDF38427.1 - 1.8e-19 69.2 0.0 3.8e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CDF38427.1 - 2.2e-18 66.1 0.1 6e-18 64.7 0.1 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDF38427.1 - 5.2e-18 66.1 1.3 6.2e-10 39.7 0.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF38427.1 - 4.3e-06 26.7 2.7 0.0046 16.7 1.5 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF38427.1 - 0.033 14.6 0.0 0.35 11.3 0.0 2.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Nucleoporin_FG PF13634.6 CDF38428.1 - 1.2e-08 35.7 95.7 6.4e-06 26.9 23.2 5.4 2 2 1 3 3 3 3 Nucleoporin FG repeat region Rootletin PF15035.6 CDF38428.1 - 0.027 14.5 0.7 0.17 11.9 0.7 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Peptidase_C98 PF15499.6 CDF38428.1 - 0.047 13.1 0.1 0.07 12.6 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase TACC_C PF05010.14 CDF38428.1 - 0.086 12.6 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2514 PF10721.9 CDF38428.1 - 0.23 11.5 2.6 0.68 10.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) DUF3486 PF11985.8 CDF38428.1 - 2.6 8.4 7.5 3.6 8.0 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3486) Methyltrn_RNA_3 PF02598.17 CDF38429.1 - 4.9e-87 292.1 0.0 5.6e-87 291.9 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase Defensin_4 PF07936.12 CDF38429.1 - 0.53 10.2 2.8 5.3 7.0 0.2 3.0 3 0 0 3 3 3 0 Potassium-channel blocking toxin Phos_pyr_kin PF08543.12 CDF38430.1 - 3.6e-95 318.0 0.5 4.1e-95 317.8 0.5 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CDF38430.1 - 1.6e-09 37.5 0.0 2.6e-08 33.5 0.0 2.3 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 CDF38430.1 - 0.053 13.0 2.0 0.057 12.9 0.3 1.8 2 0 0 2 2 2 0 Carbohydrate kinase Cpn60_TCP1 PF00118.24 CDF38432.1 - 2.2e-91 306.9 8.1 3e-91 306.5 8.1 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HAD PF12710.7 CDF38433.1 - 1e-21 78.2 0.0 2.2e-21 77.1 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF38433.1 - 2.3e-15 57.5 0.4 5.4e-15 56.2 0.4 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ACT_6 PF13740.6 CDF38433.1 - 1.2e-13 50.9 0.3 6.1e-13 48.5 0.1 2.3 2 0 0 2 2 2 1 ACT domain Hydrolase_3 PF08282.12 CDF38433.1 - 1.3e-11 44.7 0.2 7.9e-11 42.2 0.1 2.2 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CDF38433.1 - 0.00016 21.2 0.0 0.015 14.7 0.0 2.4 2 0 0 2 2 2 1 Putative Phosphatase HAD_2 PF13419.6 CDF38433.1 - 0.0011 19.1 0.0 0.0036 17.4 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase EzrA PF06160.12 CDF38433.1 - 0.0011 17.2 0.1 0.0016 16.8 0.1 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF705 PF05152.12 CDF38433.1 - 0.079 12.4 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Vps5 PF09325.10 CDF38433.1 - 0.14 11.7 1.5 1.2 8.7 2.7 1.9 2 0 0 2 2 2 0 Vps5 C terminal like DUF4611 PF15387.6 CDF38433.1 - 2.2 8.6 4.4 6.9 7.0 3.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) CIAPIN1 PF05093.13 CDF38435.1 - 4.5e-25 88.1 13.9 2.9e-22 79.1 13.9 2.3 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis RSN1_7TM PF02714.15 CDF38436.1 - 6e-60 202.9 17.1 7.6e-60 202.6 17.1 1.1 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate Pro_isomerase PF00160.21 CDF38437.1 - 9.2e-36 123.5 0.0 1.1e-35 123.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WLM PF08325.10 CDF38438.1 - 8.4e-52 176.0 0.0 1e-51 175.8 0.0 1.0 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 CDF38438.1 - 0.0057 16.7 0.1 0.01 15.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 NAD_binding_6 PF08030.12 CDF38442.1 - 1.3e-17 64.4 0.1 2.6e-11 43.9 0.1 3.3 2 1 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CDF38442.1 - 6.2e-16 58.4 0.0 1.2e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CDF38442.1 - 6.6e-10 39.2 4.5 6.6e-10 39.2 4.5 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DEC-1_C PF04626.13 CDF38442.1 - 0.027 14.9 0.8 0.057 13.8 0.8 1.5 1 0 0 1 1 1 0 Dec-1 protein, C terminal region NAD_binding_1 PF00175.21 CDF38442.1 - 0.1 13.2 0.0 22 5.7 0.0 2.6 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CDF38442.1 - 0.17 12.3 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain DUF4405 PF14358.6 CDF38442.1 - 9.9 6.8 15.6 8 7.1 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) S1 PF00575.23 CDF38443.1 - 9.4e-44 147.6 2.2 1.9e-19 69.8 1.4 3.2 3 0 0 3 3 3 3 S1 RNA binding domain DUF493 PF04359.14 CDF38445.1 - 1e-09 38.9 0.0 2.3e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF493) Methyltrans_RNA PF04452.14 CDF38446.1 - 5.5e-43 146.9 0.2 6.8e-43 146.6 0.2 1.1 1 0 0 1 1 1 1 RNA methyltransferase CC PF04942.14 CDF38447.1 - 0.024 14.8 0.5 0.049 13.8 0.5 1.4 1 0 0 1 1 1 0 CC domain MIF4G PF02854.19 CDF38449.1 - 1.2e-32 113.3 5.4 8.4e-32 110.5 5.4 2.4 1 1 0 1 1 1 1 MIF4G domain W2 PF02020.18 CDF38449.1 - 1.4e-10 41.2 0.1 4.3e-10 39.6 0.1 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.17 CDF38449.1 - 2e-06 27.8 1.3 3e-06 27.2 0.2 2.0 2 0 0 2 2 2 1 MA3 domain CPSF100_C PF13299.6 CDF38449.1 - 2.8 8.1 12.0 0.068 13.4 1.5 2.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SAPS PF04499.15 CDF38449.1 - 6.8 5.3 8.5 0.15 10.8 0.9 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein vATP-synt_AC39 PF01992.16 CDF38451.1 - 2.6e-111 372.4 0.8 3e-111 372.2 0.8 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit E1-E2_ATPase PF00122.20 CDF38453.1 - 5e-31 107.6 0.6 5e-31 107.6 0.6 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDF38453.1 - 3.1e-21 76.6 10.8 8.5e-21 75.2 10.8 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_hydro_31 PF01055.26 CDF38454.1 - 7e-134 447.3 5.4 8.7e-134 447.0 5.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CDF38454.1 - 4e-17 62.3 0.0 1.4e-16 60.6 0.0 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 CDF38454.1 - 5.1e-06 26.7 0.0 5.1e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) TerB_C PF15615.6 CDF38454.1 - 0.035 14.4 0.2 0.061 13.6 0.2 1.3 1 0 0 1 1 1 0 TerB-C domain TPM_phosphatase PF04536.14 CDF38456.1 - 4.9e-06 26.7 0.0 6.3e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 TPM domain Pox_A_type_inc PF04508.12 CDF38456.1 - 0.00018 21.2 0.6 0.0032 17.2 1.2 2.2 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat ATP-grasp_2 PF08442.10 CDF38457.1 - 2.7e-63 213.2 0.6 6e-63 212.1 0.1 1.7 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 CDF38457.1 - 2.1e-27 95.8 0.6 4.8e-27 94.7 0.6 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CDF38457.1 - 7.5e-06 25.6 0.1 1.6e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 CDF38457.1 - 0.0013 18.5 0.2 0.035 13.9 0.1 2.5 1 1 1 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain HHH_5 PF14520.6 CDF38457.1 - 0.066 13.8 0.1 0.24 12.0 0.1 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain CCER1 PF15482.6 CDF38459.1 - 4.8 7.0 10.9 0.47 10.3 6.9 1.4 2 0 0 2 2 2 0 Coiled-coil domain-containing glutamate-rich protein family 1 S4 PF01479.25 CDF38461.1 - 1.2e-09 37.8 0.0 1.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 S4 domain Glyco_transf_5 PF08323.11 CDF38462.1 - 7.6e-31 107.7 0.0 1.4e-30 106.8 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain AMPK1_CBM PF16561.5 CDF38462.1 - 1.8e-19 69.7 0.2 4.3e-19 68.5 0.2 1.7 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Glycos_transf_1 PF00534.20 CDF38462.1 - 2e-14 53.5 0.0 3.7e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF38462.1 - 2.9e-07 31.0 0.0 7.8e-07 29.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Malt_amylase_C PF16657.5 CDF38462.1 - 0.026 14.6 0.0 0.07 13.3 0.0 1.7 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain Glyco_transf_4 PF13439.6 CDF38462.1 - 0.029 14.4 0.1 0.084 12.9 0.1 1.8 1 0 0 1 1 1 0 Glycosyltransferase Family 4 F-box-like PF12937.7 CDF38463.1 - 4.7e-11 42.4 0.9 4.7e-11 42.4 0.9 2.4 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CDF38463.1 - 8.8e-09 35.0 0.2 2e-08 33.9 0.2 1.6 1 0 0 1 1 1 1 F-box domain CBFB_NFYA PF02045.15 CDF38463.1 - 3.5 8.3 7.3 76 4.0 0.2 3.2 2 1 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B E1_dh PF00676.20 CDF38465.1 - 1.9e-105 352.1 0.5 2.2e-105 351.9 0.5 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CDF38465.1 - 0.0025 17.1 0.1 0.0043 16.3 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase SNase PF00565.17 CDF38467.1 - 1.3e-05 25.6 0.0 3.9e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 Staphylococcal nuclease homologue LTD PF00932.19 CDF38467.1 - 0.00018 21.8 0.1 0.00045 20.6 0.1 1.7 1 0 0 1 1 1 1 Lamin Tail Domain rve PF00665.26 CDF38468.1 - 1.5e-11 44.5 0.0 4.6e-10 39.7 0.0 2.3 1 1 1 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF38468.1 - 1.3e-06 28.2 0.1 2.3e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF38468.1 - 8.6e-06 25.5 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF1281_C PF18406.1 CDF38468.1 - 0.0095 15.6 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 Ferredoxin-like domain in Api92-like protein UDPG_MGDP_dh_N PF03721.14 CDF38468.1 - 0.18 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Amidinotransf PF02274.17 CDF38470.1 - 0.0013 17.9 0.0 0.017 14.2 0.0 2.1 2 0 0 2 2 2 2 Amidinotransferase zf-CHY PF05495.12 CDF38471.1 - 2.6e-13 50.3 14.6 2.6e-13 50.3 14.6 3.0 2 1 0 2 2 2 1 CHY zinc finger ANAPC4_WD40 PF12894.7 CDF38473.1 - 2e-15 56.8 6.4 0.02 15.1 0.0 8.3 5 4 3 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF38473.1 - 1.9e-12 47.5 18.5 0.051 14.5 0.2 8.5 9 1 0 9 9 9 4 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF38473.1 - 9.1e-08 32.0 3.6 9.1e-08 32.0 3.6 3.5 2 2 1 3 3 3 2 PQQ-like domain PD40 PF07676.12 CDF38473.1 - 0.0001 22.1 5.4 21 5.2 0.1 6.6 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 CDF38473.1 - 0.00044 20.0 11.9 0.25 11.3 0.2 6.5 7 0 0 7 7 7 1 PQQ enzyme repeat eIF2A PF08662.11 CDF38473.1 - 0.00081 19.3 0.5 0.16 11.9 0.0 4.2 4 1 0 5 5 5 1 Eukaryotic translation initiation factor eIF2A TFIIIC_delta PF12657.7 CDF38473.1 - 0.01 15.8 0.7 18 5.2 0.1 4.1 4 0 0 4 4 4 1 Transcription factor IIIC subunit delta N-term Flavin_Reduct PF01613.18 CDF38478.1 - 2.9e-09 37.2 4.3 1.5e-08 34.8 2.1 2.7 2 1 0 2 2 2 1 Flavin reductase like domain Thioredoxin PF00085.20 CDF38479.1 - 1.1e-10 41.5 0.4 3.6e-09 36.6 0.1 2.2 2 0 0 2 2 2 2 Thioredoxin HlyC PF02794.16 CDF38479.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 RTX toxin acyltransferase family Peptidase_M14 PF00246.24 CDF38480.1 - 4e-16 59.7 0.0 3.2e-14 53.4 0.0 2.2 1 1 0 1 1 1 1 Zinc carboxypeptidase FANCI_S2 PF14676.6 CDF38481.1 - 8.3e-08 32.7 1.8 2.1e-07 31.4 0.2 2.7 3 0 0 3 3 3 1 FANCI solenoid 2 DCB PF16213.5 CDF38481.1 - 0.097 12.3 0.5 2.1 8.0 0.0 3.0 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 DUF21 PF01595.20 CDF38482.1 - 6.4e-34 117.2 3.6 9.1e-34 116.7 3.6 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 CDF38482.1 - 4.7e-19 68.2 0.0 1.3e-18 66.7 0.0 1.8 1 0 0 1 1 1 1 Transporter associated domain CBS PF00571.28 CDF38482.1 - 5.3e-15 55.6 7.2 3e-09 37.2 0.2 3.4 3 0 0 3 3 3 2 CBS domain Ribosomal_L14 PF00238.19 CDF38487.1 - 4.5e-36 123.6 0.2 5.4e-36 123.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e DUF4537 PF15057.6 CDF38488.1 - 0.045 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) TUDOR_5 PF18359.1 CDF38488.1 - 0.062 13.0 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 Methyltransf_3 PF01596.17 CDF38490.1 - 7e-42 143.0 0.1 8.2e-42 142.8 0.1 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.6 CDF38490.1 - 2e-07 31.0 0.1 2.3e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CDF38490.1 - 3.4e-07 31.2 0.0 5.6e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDF38490.1 - 1.1e-06 28.4 0.0 1.4e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDF38490.1 - 3.7e-06 27.6 0.1 7.1e-06 26.7 0.1 1.5 1 1 1 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CDF38490.1 - 8.4e-05 22.4 0.0 0.00011 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CDF38490.1 - 0.00026 20.6 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Spermine_synth PF01564.17 CDF38490.1 - 0.00031 20.2 0.1 0.00043 19.7 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 CDF38490.1 - 0.068 13.0 0.0 0.085 12.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 CDF38490.1 - 0.074 12.4 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Sel1 PF08238.12 CDF38491.1 - 6.8e-146 471.4 50.7 2e-06 28.2 0.1 21.9 22 0 0 22 22 22 21 Sel1 repeat TPR_6 PF13174.6 CDF38491.1 - 4.1e-29 99.2 31.4 0.061 14.0 0.0 15.6 21 0 0 21 21 21 10 Tetratricopeptide repeat TPR_17 PF13431.6 CDF38491.1 - 2.4e-22 77.6 0.1 40 4.9 0.0 17.9 21 0 0 21 21 21 0 Tetratricopeptide repeat 3-HAO PF06052.12 CDF38491.1 - 0.0041 16.8 4.4 8.4 6.0 0.0 6.2 8 0 0 8 8 8 1 3-hydroxyanthranilic acid dioxygenase CNTF PF01110.17 CDF38491.1 - 0.026 13.9 0.2 0.057 12.8 0.2 1.5 1 0 0 1 1 1 0 Ciliary neurotrophic factor TPR_7 PF13176.6 CDF38491.1 - 1 9.5 13.5 1.7 8.8 0.1 8.4 11 0 0 11 11 11 0 Tetratricopeptide repeat AhpC-TSA PF00578.21 CDF38492.1 - 2.7e-27 95.1 0.0 4e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDF38492.1 - 9.7e-17 61.0 0.1 5e-15 55.5 0.1 2.3 1 1 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 CDF38492.1 - 0.051 13.7 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 AhpC/TSA antioxidant enzyme Glutaredoxin PF00462.24 CDF38492.1 - 0.19 12.0 0.1 0.52 10.6 0.0 1.7 2 0 0 2 2 2 0 Glutaredoxin Thioredoxin PF00085.20 CDF38493.1 - 5.2e-19 68.1 0.0 1.4e-12 47.5 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 CDF38493.1 - 0.0059 17.0 0.1 0.049 14.1 0.0 2.5 3 0 0 3 3 3 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CDF38493.1 - 0.02 14.2 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Peptidase_M24_C PF16188.5 CDF38493.1 - 0.071 13.2 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of peptidase_M24 Thioredoxin_4 PF13462.6 CDF38493.1 - 0.088 13.0 0.1 0.29 11.3 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin PsbQ PF05757.11 CDF38494.1 - 0.00018 21.3 8.4 0.0019 18.0 8.4 2.1 1 1 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) Retrotrans_gag PF03732.17 CDF38494.1 - 0.008 16.4 0.1 0.014 15.6 0.1 1.3 1 0 0 1 1 1 1 Retrotransposon gag protein ATP-synt_G PF04718.15 CDF38496.1 - 1.7e-05 25.5 0.0 2.6e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Saf-Nte_pilin PF09460.10 CDF38496.1 - 0.089 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Saf-pilin pilus formation protein DUF1320 PF07030.12 CDF38498.1 - 0.055 13.6 1.5 1.2 9.3 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1320) PI3Ka PF00613.20 CDF38498.1 - 0.1 12.0 0.0 0.28 10.5 0.0 1.7 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4129 PF13559.6 CDF38498.1 - 8.8 6.7 8.9 3.1 8.1 2.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4129) Ank_2 PF12796.7 CDF38499.1 - 1.5e-38 131.3 10.9 3.5e-17 62.8 1.6 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDF38499.1 - 1.1e-28 99.3 1.2 7.6e-13 48.7 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDF38499.1 - 9.6e-26 89.5 1.7 5.9e-10 39.2 0.2 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDF38499.1 - 9.3e-22 74.8 0.3 1.1e-05 25.3 0.1 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 CDF38499.1 - 4.1e-20 71.3 1.8 4.6e-06 26.8 0.1 3.9 4 0 0 4 4 4 3 Ankyrin repeat DUF2336 PF10098.9 CDF38499.1 - 0.021 14.3 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) R3H PF01424.22 CDF38500.1 - 9.1e-07 28.8 0.1 1.9e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 CDF38500.1 - 0.00023 21.2 14.7 0.00023 21.2 14.7 14.3 14 2 0 14 14 14 6 NF-X1 type zinc finger FXMRP1_C_core PF12235.8 CDF38500.1 - 2 9.1 14.0 1.9 9.2 0.1 2.8 3 0 0 3 3 3 0 Fragile X-related 1 protein core C terminal tRNA_int_endo PF01974.17 CDF38501.1 - 7.5e-17 61.2 0.0 1.3e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain RB_A PF01858.17 CDF38503.1 - 0.049 13.5 1.6 0.081 12.8 1.6 1.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain BAR PF03114.18 CDF38503.1 - 0.1 12.2 7.2 0.19 11.4 7.2 1.4 1 0 0 1 1 1 0 BAR domain ACP_PD PF04336.12 CDF38503.1 - 0.25 11.8 1.7 0.42 11.1 0.5 2.0 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase YicC_N PF03755.13 CDF38503.1 - 0.8 10.1 4.2 1.1 9.7 0.7 2.2 1 1 1 2 2 2 0 YicC-like family, N-terminal region BRE1 PF08647.11 CDF38503.1 - 2.7 8.1 10.4 0.43 10.7 4.8 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF948 PF06103.11 CDF38504.1 - 0.0055 16.9 3.2 0.23 11.7 0.2 3.0 3 2 0 3 3 3 2 Bacterial protein of unknown function (DUF948) Flagellar_rod PF05149.12 CDF38504.1 - 0.11 12.0 4.9 0.33 10.4 0.1 2.5 2 1 0 2 2 2 0 Paraflagellar rod protein XRN_M PF17846.1 CDF38504.1 - 0.17 10.8 2.2 0.27 10.1 2.2 1.3 1 0 0 1 1 1 0 Xrn1 helical domain CHD5 PF04420.14 CDF38504.1 - 1.4 8.7 7.9 0.13 12.1 2.5 1.9 2 1 0 2 2 2 0 CHD5-like protein DUF1664 PF07889.12 CDF38504.1 - 1.6 8.8 5.3 1.7 8.7 0.3 2.9 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) TPK_B1_binding PF04265.14 CDF38505.1 - 1.9e-19 69.1 0.0 2.4e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain ApbA_C PF08546.11 CDF38506.1 - 0.11 12.7 0.0 0.46 10.7 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal Peptidase_S9 PF00326.21 CDF38507.1 - 6.6e-24 84.6 0.0 1e-23 84.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 CDF38507.1 - 0.00029 20.7 5.8 1.2 9.2 0.6 3.7 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Peptidase_S15 PF02129.18 CDF38507.1 - 0.0056 16.3 0.1 0.0098 15.5 0.1 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) COesterase PF00135.28 CDF38507.1 - 0.024 13.5 0.1 0.036 12.9 0.1 1.2 1 0 0 1 1 1 0 Carboxylesterase family Hydrolase_4 PF12146.8 CDF38507.1 - 0.029 13.6 0.0 1.8 7.7 0.0 2.8 2 1 1 3 3 3 0 Serine aminopeptidase, S33 BAAT_C PF08840.11 CDF38507.1 - 0.24 11.3 0.0 0.45 10.4 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal RT_RNaseH PF17917.1 CDF38508.1 - 6.5e-32 109.9 0.0 1.3e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38508.1 - 1.4e-29 102.1 0.0 2.4e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Pkinase PF00069.25 CDF38509.1 - 3.1e-56 190.7 0.0 3.8e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38509.1 - 1.1e-25 90.4 0.0 1.5e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF38509.1 - 1.3e-06 27.9 0.0 0.00056 19.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CDF38509.1 - 0.04 12.7 0.1 0.078 11.7 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 CDF38509.1 - 0.076 12.9 0.1 0.4 10.6 0.1 2.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family Arm PF00514.23 CDF38510.1 - 2.5e-05 24.2 2.9 0.065 13.3 0.0 4.7 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDF38510.1 - 0.83 10.2 6.3 43 4.8 0.4 4.1 4 0 0 4 4 4 0 HEAT-like repeat RT_RNaseH PF17917.1 CDF38512.1 - 3.4e-37 126.9 0.0 5.4e-35 119.8 0.0 3.1 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF38512.1 - 2.2e-35 120.7 0.0 9.8e-35 118.6 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF38512.1 - 1.1e-19 70.8 0.0 2e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF38512.1 - 1.1e-05 25.5 0.1 2.4e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF38512.1 - 2e-05 24.4 0.5 0.00017 21.4 0.0 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF38512.1 - 0.025 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 CDF38512.1 - 0.027 14.0 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DHDPS PF00701.22 CDF38514.1 - 3.4e-44 150.7 0.0 3.8e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family CBM46 PF18448.1 CDF38514.1 - 0.03 14.6 0.1 0.061 13.6 0.0 1.5 1 1 0 1 1 1 0 Carbohydrate binding domain FHA PF00498.26 CDF38515.1 - 4.8e-12 46.1 0.0 1.1e-11 44.9 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDF38515.1 - 0.00013 22.2 0.0 0.00042 20.6 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain CHDCT2 PF08074.11 CDF38515.1 - 0.028 14.6 2.2 0.078 13.2 2.2 1.7 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain PrsW-protease PF13367.6 CDF38516.1 - 5.8e-11 42.2 14.1 1.8e-10 40.6 14.1 1.9 1 1 0 1 1 1 1 PrsW family intramembrane metalloprotease UPF0542 PF15086.6 CDF38516.1 - 3.5 7.6 8.4 0.51 10.3 1.6 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 PIF1 PF05970.14 CDF38517.1 - 5.3e-72 243.0 0.0 4.3e-62 210.4 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF38517.1 - 2.3e-45 155.2 1.5 3e-45 154.8 0.0 2.0 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus UvrD_C_2 PF13538.6 CDF38517.1 - 0.039 13.8 0.0 0.092 12.6 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain PTH2 PF01981.16 CDF38518.1 - 6.3e-18 65.2 0.1 8.3e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 tRNA_bind PF01588.20 CDF38521.1 - 1.3e-23 82.9 0.0 2.5e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain THOC2_N PF16134.5 CDF38521.1 - 0.25 10.0 0.5 0.33 9.5 0.5 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus SMC_N PF02463.19 CDF38522.1 - 9.6e-65 218.1 40.9 4.3e-64 216.0 40.9 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDF38522.1 - 4.8e-26 91.4 0.0 1.9e-25 89.4 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CDF38522.1 - 1.9e-14 54.2 2.0 1.5e-06 28.3 0.0 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDF38522.1 - 3.7e-12 46.6 0.0 3.7e-12 46.6 0.0 3.7 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 CDF38522.1 - 1.1e-05 25.1 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDF38522.1 - 1.1e-05 26.0 29.7 1.1e-05 26.0 29.7 5.6 2 2 0 2 2 2 1 AAA domain DUF4201 PF13870.6 CDF38522.1 - 0.0073 16.1 4.9 0.0073 16.1 4.9 7.2 3 3 3 6 6 6 1 Domain of unknown function (DUF4201) ABC_tran PF00005.27 CDF38522.1 - 0.17 12.4 0.0 0.17 12.4 0.0 5.1 3 2 1 4 4 4 0 ABC transporter rve PF00665.26 CDF38524.1 - 5.7e-11 42.7 0.1 8.9e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF38524.1 - 0.051 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain MLVIN_C PF18697.1 CDF38524.1 - 0.075 13.1 0.3 0.3 11.2 0.1 2.1 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain PuR_N PF09182.10 CDF38525.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal Xan_ur_permease PF00860.20 CDF38528.1 - 7.9e-70 235.5 28.0 2e-45 155.1 12.5 2.1 1 1 1 2 2 2 2 Permease family ChAPs PF09295.10 CDF38529.1 - 5.2e-37 127.8 0.0 9e-37 127.0 0.0 1.4 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_8 PF13181.6 CDF38529.1 - 3.4e-07 29.9 0.8 0.13 12.5 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDF38529.1 - 5.8e-07 29.1 5.5 0.038 13.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38529.1 - 3.5e-06 27.4 10.0 0.00031 21.3 0.1 4.4 3 1 1 4 4 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF38529.1 - 4.9e-05 23.5 1.0 0.00029 21.0 0.1 2.7 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 CDF38529.1 - 0.00013 21.8 9.7 0.13 12.4 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38529.1 - 0.00017 22.0 1.8 0.0069 16.9 0.1 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDF38529.1 - 0.0079 15.4 0.1 0.0079 15.4 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF38529.1 - 0.035 14.2 3.0 7.8 6.7 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF38529.1 - 0.049 13.7 0.6 7.3 6.9 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDF38529.1 - 0.08 13.4 0.0 0.67 10.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.8 CDF38529.1 - 0.095 11.6 0.2 2 7.3 0.1 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 CDF38529.1 - 0.16 12.7 1.6 64 4.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDF38529.1 - 0.22 11.2 7.3 3.9 7.1 0.0 3.4 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain TPR_16 PF13432.6 CDF38529.1 - 0.47 11.2 14.9 0.11 13.2 0.7 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat HA2 PF04408.23 CDF38530.1 - 6.8e-25 87.4 0.3 2.2e-24 85.8 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDF38530.1 - 3.3e-23 81.8 0.0 6.7e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDF38530.1 - 1.3e-11 44.8 0.0 3e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF38530.1 - 1.1e-08 35.0 0.3 2.2e-08 34.1 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase S1 PF00575.23 CDF38530.1 - 1.3e-06 28.6 0.0 2.7e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 CDF38530.1 - 8e-05 22.9 0.3 0.0003 21.1 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF38530.1 - 0.00057 19.7 0.1 0.0014 18.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDF38530.1 - 0.0042 16.2 0.0 0.065 12.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 CDF38530.1 - 0.033 14.7 0.0 0.16 12.5 0.0 2.3 2 0 0 2 2 2 0 ABC transporter PhoH PF02562.16 CDF38530.1 - 0.042 13.3 0.1 0.11 12.0 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 CDF38530.1 - 0.049 14.0 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CDF38530.1 - 0.07 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 CDF38530.1 - 0.1 12.1 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CDF38530.1 - 0.14 12.2 0.3 1.7 8.7 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDF38530.1 - 0.14 11.9 0.0 0.61 9.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain Flavi_DEAD PF07652.14 CDF38530.1 - 0.15 12.0 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain ELO PF01151.18 CDF38531.1 - 1.6e-53 181.8 27.9 1.9e-53 181.6 27.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DUF5090 PF17009.5 CDF38531.1 - 0.49 10.3 7.9 0.56 10.1 6.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5090) zf-tcix PF14952.6 CDF38534.1 - 2.2e-06 27.2 20.3 0.00019 21.0 9.9 2.3 1 1 1 2 2 2 2 Putative treble-clef, zinc-finger, Zn-binding UPF0547 PF10571.9 CDF38534.1 - 5e-06 26.5 22.8 0.00025 21.1 6.7 2.4 2 0 0 2 2 2 2 Uncharacterised protein family UPF0547 DZR PF12773.7 CDF38534.1 - 0.0036 17.3 17.0 0.0079 16.2 17.0 1.6 1 0 0 1 1 1 1 Double zinc ribbon Zn_ribbon_17 PF17120.5 CDF38534.1 - 0.0073 15.9 8.8 0.17 11.5 1.0 2.3 2 0 0 2 2 2 2 Zinc-ribbon, C4HC2 type TerY_C PF15616.6 CDF38534.1 - 0.76 9.9 12.1 1.4 9.0 2.8 2.4 1 1 1 2 2 2 0 TerY-C metal binding domain Zn-ribbon_8 PF09723.10 CDF38534.1 - 1.1 9.4 14.9 5.7 7.1 4.0 3.5 2 1 1 3 3 3 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 CDF38534.1 - 2.6 8.9 17.7 0.44 11.3 1.3 2.5 1 1 1 2 2 2 0 zinc-ribbon family Putative_PNPOx PF01243.20 CDF38535.1 - 5.4e-25 87.4 0.1 1.1e-24 86.4 0.0 1.5 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 CDF38535.1 - 9.8e-18 64.0 2.5 2e-17 63.0 2.5 1.6 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 CDF38535.1 - 0.00014 22.5 0.0 0.00023 21.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase RNase_PH PF01138.21 CDF38536.1 - 3.9e-12 46.8 0.3 9.2e-12 45.6 0.3 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF38536.1 - 1.1e-09 38.2 0.0 2.7e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SapB_1 PF05184.15 CDF38538.1 - 0.14 12.2 0.8 14 5.8 0.1 2.4 2 0 0 2 2 2 0 Saposin-like type B, region 1 PB1 PF00564.24 CDF38540.1 - 5.5e-14 51.9 0.0 1.1e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 PB1 domain PG_binding_1 PF01471.18 CDF38540.1 - 4.7e-10 39.5 0.0 8.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain ZZ PF00569.17 CDF38540.1 - 1.5e-08 34.3 1.9 2.5e-08 33.6 1.9 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Heme_oxygenase PF01126.20 CDF38541.1 - 1.6e-43 148.9 0.0 1.9e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Heme oxygenase Helitron_like_N PF14214.6 CDF38542.1 - 2.3e-50 171.5 0.0 3.7e-50 170.8 0.0 1.3 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AMNp_N PF10423.9 CDF38542.1 - 0.0095 15.6 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial AMP nucleoside phosphorylase N-terminus Plant_tran PF04827.14 CDF38544.1 - 7.7e-80 267.3 0.0 1.1e-79 266.8 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF38544.1 - 5.8e-12 45.6 0.0 1.3e-11 44.4 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Dimer_Tnp_hAT PF05699.14 CDF38545.1 - 0.017 14.9 0.1 0.056 13.2 0.0 1.9 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region DUF4413 PF14372.6 CDF38545.1 - 0.061 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) SLAC1 PF03595.17 CDF38546.1 - 2.8e-24 86.0 41.4 3.6e-24 85.6 41.4 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF4501 PF14946.6 CDF38546.1 - 0.13 12.3 0.7 0.46 10.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) FA_hydroxylase PF04116.13 CDF38548.1 - 2.6e-14 53.7 4.2 2.6e-14 53.7 4.2 2.4 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily Beta_propel PF09826.9 CDF38549.1 - 0.16 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Beta propeller domain WD40 PF00400.32 CDF38550.1 - 2.2e-13 50.4 17.2 0.094 13.6 0.1 10.0 9 0 0 9 9 9 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38550.1 - 1.7e-12 47.4 12.5 0.84 10.0 0.1 10.1 5 1 7 12 12 12 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF38550.1 - 3e-06 27.0 26.4 2.3e-05 24.1 4.0 4.1 2 2 1 3 3 3 3 PQQ-like domain eIF2A PF08662.11 CDF38550.1 - 1.6e-05 24.9 0.7 0.0044 16.9 0.0 4.3 4 2 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A NB-ARC PF00931.22 CDF38550.1 - 0.00031 20.0 0.0 0.00063 19.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain PD40 PF07676.12 CDF38550.1 - 0.0083 16.0 16.5 35 4.5 0.1 8.5 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat APAF1_C PF17908.1 CDF38550.1 - 0.015 15.3 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain PQQ PF01011.21 CDF38550.1 - 0.043 13.8 16.0 0.32 11.0 0.1 6.1 6 0 0 6 6 6 0 PQQ enzyme repeat TcpQ PF10671.9 CDF38550.1 - 0.076 13.1 0.1 18 5.5 0.1 3.0 2 0 0 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q TFIIIC_delta PF12657.7 CDF38550.1 - 0.45 10.4 1.8 45 3.9 0.0 3.9 4 0 0 4 4 4 0 Transcription factor IIIC subunit delta N-term Flavin_Reduct PF01613.18 CDF38552.1 - 4.9e-06 26.7 0.1 6.7e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Flavin reductase like domain Keratin_2_head PF16208.5 CDF38555.1 - 0.052 13.7 0.9 0.073 13.2 0.9 1.1 1 0 0 1 1 1 0 Keratin type II head CDH PF02611.15 CDF38559.1 - 0.0096 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase zf-Paramyx-P PF13008.7 CDF38562.1 - 1.3 8.6 6.9 12 5.4 2.7 2.8 1 1 1 2 2 2 0 Zinc-binding domain of Paramyxoviridae V protein SPX PF03105.19 CDF38564.1 - 0.062 13.2 13.8 0.081 12.8 13.8 1.2 1 0 0 1 1 1 0 SPX domain DMAP_binding PF06464.11 CDF38564.1 - 2.2 9.1 5.7 17 6.3 3.7 2.1 2 0 0 2 2 2 0 DMAP1-binding Domain HTH_Tnp_Tc3_1 PF11427.8 CDF38566.1 - 8.8e-09 35.1 0.0 1.7e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF38566.1 - 2e-05 24.2 0.4 0.00015 21.4 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 CDF38566.1 - 0.001 19.1 0.1 0.0093 16.0 0.1 2.6 2 1 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 CDF38566.1 - 0.0013 19.0 4.8 0.0014 18.8 2.0 2.1 2 0 0 2 2 2 1 Transposase Sigma70_r4_2 PF08281.12 CDF38566.1 - 0.033 13.8 0.0 0.077 12.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_24 PF13412.6 CDF38566.1 - 0.054 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_7 PF02796.15 CDF38566.1 - 0.055 13.5 0.9 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 CDF38566.1 - 0.17 11.7 2.1 0.45 10.4 0.0 2.7 4 0 0 4 4 4 0 Homeodomain-like domain HTH_32 PF13565.6 CDF38566.1 - 0.45 11.2 9.9 0.87 10.2 4.8 3.2 2 1 2 4 4 4 0 Homeodomain-like domain DDE_3 PF13358.6 CDF38567.1 - 6.8e-15 55.1 0.0 9.2e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1995 PF09353.10 CDF38568.1 - 1.2e-18 67.9 0.1 1.8e-18 67.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Pkinase PF00069.25 CDF38569.1 - 8.4e-60 202.4 0.0 1.2e-59 201.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38569.1 - 1.4e-44 152.3 0.0 2.2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CDF38569.1 - 9.9e-17 61.1 0.2 2.9e-08 33.9 0.1 3.2 2 0 0 2 2 2 2 P21-Rho-binding domain Pkinase_fungal PF17667.1 CDF38569.1 - 8.1e-07 28.1 0.2 7.3e-05 21.7 0.0 2.4 2 0 0 2 2 2 2 Fungal protein kinase Haspin_kinase PF12330.8 CDF38569.1 - 0.0045 16.0 0.6 0.012 14.5 0.6 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF38569.1 - 0.092 12.0 0.0 0.22 10.8 0.0 1.6 2 0 0 2 2 2 0 Kinase-like LSM PF01423.22 CDF38570.1 - 2.6e-17 62.3 0.0 3.3e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDF38570.1 - 0.0011 19.1 0.0 0.0016 18.6 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain GRP PF07172.11 CDF38570.1 - 0.91 10.3 19.2 1.4 9.6 19.2 1.3 1 0 0 1 1 1 0 Glycine rich protein family Ribosomal_S16 PF00886.19 CDF38571.1 - 6.2e-25 87.0 0.2 8e-25 86.7 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 TruB_C PF09142.11 CDF38571.1 - 0.018 14.8 0.2 0.029 14.2 0.2 1.3 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal DDOST_48kD PF03345.14 CDF38573.1 - 2.7e-89 299.9 0.0 3.1e-89 299.7 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF2194 PF09960.9 CDF38573.1 - 0.00016 20.2 0.0 0.00022 19.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2194) DUF4350 PF14258.6 CDF38573.1 - 0.036 14.5 0.0 0.19 12.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) ABC_tran PF00005.27 CDF38574.1 - 5.5e-32 111.1 0.0 9.8e-32 110.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDF38574.1 - 5.7e-11 42.6 0.5 8.8e-11 42.0 0.5 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDF38574.1 - 8.7e-07 28.6 0.0 2.1e-05 24.1 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDF38574.1 - 0.00011 22.6 0.0 0.00025 21.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDF38574.1 - 0.00016 21.6 0.0 0.00043 20.2 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CDF38574.1 - 0.0012 19.1 0.0 0.019 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CDF38574.1 - 0.0037 17.5 0.0 0.0073 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF38574.1 - 0.0037 17.0 0.1 0.0096 15.6 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CDF38574.1 - 0.0079 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_30 PF13604.6 CDF38574.1 - 0.0081 15.9 0.0 0.02 14.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDF38574.1 - 0.0094 16.1 0.0 0.084 13.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDF38574.1 - 0.013 15.6 0.1 0.026 14.6 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase SHNi-TPR PF10516.9 CDF38574.1 - 0.014 14.8 0.1 0.091 12.2 0.0 2.4 2 0 0 2 2 2 0 SHNi-TPR AAA_21 PF13304.6 CDF38574.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDF38574.1 - 0.017 14.9 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 CDF38574.1 - 0.022 14.6 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 CDF38574.1 - 0.033 14.6 0.0 8 6.9 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 CDF38574.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF38574.1 - 0.14 11.7 0.0 0.33 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CDF38575.1 - 1.3e-31 109.9 0.0 2.3e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDF38575.1 - 2.6e-14 53.5 7.6 7.9e-09 35.5 0.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CDF38575.1 - 6e-06 25.8 0.0 7.6e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDF38575.1 - 0.00029 20.8 0.0 0.00072 19.5 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDF38575.1 - 0.0011 19.4 0.0 0.0027 18.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF38575.1 - 0.0055 16.4 0.1 0.015 15.0 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDF38575.1 - 0.0072 16.6 0.0 0.073 13.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDF38575.1 - 0.0088 15.3 0.1 0.048 12.9 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 CDF38575.1 - 0.021 14.5 0.0 0.051 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDF38575.1 - 0.022 14.5 0.1 0.036 13.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CDF38575.1 - 0.022 14.9 0.0 0.13 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CDF38575.1 - 0.029 14.5 0.0 0.072 13.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase SHNi-TPR PF10516.9 CDF38575.1 - 0.036 13.5 0.1 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 SHNi-TPR AAA_28 PF13521.6 CDF38575.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDF38575.1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 CDF38575.1 - 0.2 12.1 0.0 0.36 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RMI1_N PF08585.12 CDF38576.1 - 3.4e-17 62.9 1.5 1.7e-11 44.3 0.0 2.9 2 1 1 3 3 3 2 RecQ mediated genome instability protein LSM PF01423.22 CDF38578.1 - 5.1e-21 74.1 0.2 5.6e-21 74.0 0.2 1.0 1 0 0 1 1 1 1 LSM domain SAPS PF04499.15 CDF38581.1 - 1.8e-09 37.0 0.0 2.9e-05 23.1 0.0 3.1 2 1 1 3 3 3 3 SIT4 phosphatase-associated protein DCB PF16213.5 CDF38581.1 - 0.13 11.9 0.1 0.35 10.5 0.1 1.6 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 Sel1 PF08238.12 CDF38583.1 - 4.2e-49 163.9 14.2 2e-06 28.3 0.0 9.5 9 0 0 9 9 9 9 Sel1 repeat TPR_17 PF13431.6 CDF38583.1 - 1.7e-08 34.3 9.3 3.6 8.2 0.2 9.7 8 4 2 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38583.1 - 3.3e-07 30.8 12.5 1.7 9.4 1.8 7.1 4 3 3 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF38583.1 - 2.5e-06 27.8 18.7 0.42 11.3 0.0 8.3 8 2 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38583.1 - 0.0072 17.1 10.5 2.4 9.2 0.8 6.5 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF38583.1 - 0.019 14.9 14.4 3.8 7.8 0.1 8.2 7 2 2 9 9 9 0 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF38583.1 - 0.027 14.7 0.0 11 6.4 0.0 2.9 1 1 1 2 2 2 0 Arginine decarboxylase helical bundle domain HetR_C PF18460.1 CDF38583.1 - 0.037 13.9 1.4 1.5 8.8 0.1 3.4 2 1 1 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain PIF1 PF05970.14 CDF38585.1 - 8.4e-94 314.7 0.0 1.2e-93 314.1 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF38585.1 - 6.1e-60 202.7 0.0 1.5e-59 201.4 0.0 1.7 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF38585.1 - 3.5e-06 26.9 0.0 6.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF38585.1 - 0.053 13.2 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF38585.1 - 0.085 10.8 0.0 0.14 10.1 0.0 1.2 1 0 0 1 1 1 0 Helicase Dus PF01207.17 CDF38587.1 - 1e-72 244.9 0.0 1.3e-72 244.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 CDF38587.1 - 5.5e-05 22.5 0.0 0.00014 21.1 0.0 1.6 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 CDF38587.1 - 0.015 14.6 0.0 0.084 12.2 0.0 2.3 4 0 0 4 4 4 0 Thiamine monophosphate synthase NPA PF16469.5 CDF38587.1 - 0.098 13.2 0.3 0.27 11.8 0.1 1.7 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 Imm30 PF15565.6 CDF38589.1 - 0.092 12.8 0.0 0.42 10.7 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 30 Hemerythrin PF01814.23 CDF38589.1 - 0.095 13.3 8.5 0.038 14.6 4.5 2.2 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain Glyco_transf_11 PF01531.16 CDF38590.1 - 2.2e-05 23.9 0.0 5.2e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 11 Glyco_transf_18 PF15024.6 CDF38591.1 - 8.6e-07 27.9 2.5 1e-06 27.7 2.5 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 FKBP_C PF00254.28 CDF38591.1 - 0.0038 17.5 0.0 0.0077 16.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ribosomal_L1 PF00687.21 CDF38593.1 - 6.3e-31 107.7 0.6 8.5e-30 104.0 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family HSP70 PF00012.20 CDF38594.1 - 7.8e-253 840.1 16.8 9.4e-253 839.8 16.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDF38594.1 - 2.4e-19 69.3 0.6 6.6e-18 64.6 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CDF38594.1 - 0.0018 18.0 0.1 0.014 15.1 0.0 2.4 3 0 0 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 CDF38594.1 - 0.044 14.2 8.7 5.6 7.4 0.4 3.9 3 2 0 3 3 3 0 Cell division protein FtsA Zincin_2 PF10103.9 CDF38594.1 - 0.058 12.6 0.3 5.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Zincin-like metallopeptidase Hydantoinase_A PF01968.18 CDF38594.1 - 0.21 10.8 7.1 0.11 11.7 0.1 2.8 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase Abhydrolase_6 PF12697.7 CDF38599.1 - 0.0053 17.4 0.4 0.0096 16.5 0.1 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Amidohydro_1 PF01979.20 CDF38601.1 - 1.4e-07 31.2 0.1 1.8e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 CDF38601.1 - 0.12 12.1 0.2 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Amidohydrolase MnmE_helical PF12631.7 CDF38604.1 - 9.3e-46 156.6 0.1 1.1e-45 156.4 0.1 1.0 1 0 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 CDF38604.1 - 1.6e-22 79.7 0.1 2.9e-22 78.9 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF38604.1 - 1.5e-07 31.5 0.2 0.011 15.6 0.0 2.6 2 1 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDF38604.1 - 1.9e-07 31.3 0.0 1.2e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 CDF38604.1 - 2.6e-07 30.3 0.0 4.9e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B TrmE_N PF10396.9 CDF38604.1 - 1.5e-05 25.3 0.2 0.00021 21.6 0.2 2.4 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus GTP_EFTU PF00009.27 CDF38604.1 - 1.6e-05 24.6 0.0 0.075 12.6 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 CDF38604.1 - 0.00023 20.7 0.0 0.028 13.9 0.0 2.6 2 1 0 2 2 2 1 ADP-ribosylation factor family ABC_tran PF00005.27 CDF38604.1 - 0.00038 21.0 0.2 0.00099 19.6 0.1 1.8 1 1 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 CDF38604.1 - 0.0016 18.7 0.0 0.003 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 CDF38604.1 - 0.0017 18.0 0.1 0.62 9.6 0.0 2.3 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CDF38604.1 - 0.0026 17.4 0.0 0.0076 16.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF38604.1 - 0.017 15.5 0.2 2.1 8.7 0.0 2.4 1 1 1 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CDF38604.1 - 0.028 13.8 0.2 0.36 10.1 0.0 2.3 1 1 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 CDF38604.1 - 0.03 14.5 0.0 0.28 11.4 0.0 2.4 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 CDF38604.1 - 0.05 12.7 0.0 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 CDF38604.1 - 0.054 13.2 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 CDF38604.1 - 0.067 12.8 0.0 0.18 11.4 0.0 1.6 1 1 0 1 1 1 0 Ras family AIG1 PF04548.16 CDF38604.1 - 0.085 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_18 PF13238.6 CDF38604.1 - 0.12 12.9 0.0 0.34 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain Cyclin PF08613.11 CDF38606.1 - 3.4e-28 99.0 0.3 3.4e-28 99.0 0.3 1.8 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CDF38606.1 - 1.6e-06 27.9 0.0 2.9e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain RNA_pol_Rpb1_5 PF04998.17 CDF38608.1 - 6.8e-106 353.6 0.2 1.1e-105 352.9 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 CDF38608.1 - 2.1e-94 316.4 0.0 3.6e-94 315.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CDF38608.1 - 1.2e-70 237.1 1.3 3.6e-70 235.5 0.0 2.4 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 CDF38608.1 - 1.3e-50 171.9 2.0 1.3e-50 171.9 0.6 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 CDF38608.1 - 6.4e-49 165.9 0.0 1.3e-48 164.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 CDF38608.1 - 1.5e-39 135.1 1.3 3.7e-39 133.8 1.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 CDF38608.1 - 5.8e-35 119.5 0.1 1.5e-34 118.2 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF1388 PF07142.12 CDF38608.1 - 6.4 6.8 8.2 5.1 7.2 0.4 3.5 3 0 0 3 3 3 0 Repeat of unknown function (DUF1388) TAF4 PF05236.14 CDF38609.1 - 2.1e-12 47.4 9.2 2.1e-12 47.4 9.2 2.2 2 1 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family SAGA-Tad1 PF12767.7 CDF38609.1 - 0.27 11.0 13.0 0.042 13.6 3.0 3.3 2 1 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit ETC_C1_NDUFA4 PF04800.12 CDF38610.1 - 4.2e-28 97.5 0.1 6.1e-28 96.9 0.1 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region PPTA PF01239.22 CDF38611.1 - 2.9e-35 118.9 8.8 1.3e-09 37.4 0.0 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF4219 PF13961.6 CDF38611.1 - 0.38 10.5 5.7 8.2 6.2 0.0 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4219) SMP_LBD PF17047.5 CDF38612.1 - 2.5e-25 89.0 0.0 3.7e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 CDF38612.1 - 4.1e-15 55.9 0.0 1.2e-09 38.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain Complex1_30kDa PF00329.19 CDF38613.1 - 9e-40 136.1 0.1 1.3e-39 135.6 0.1 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit LSM PF01423.22 CDF38615.1 - 1.6e-18 66.2 0.0 1.9e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDF38615.1 - 0.0014 18.7 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Thiolase_N PF00108.23 CDF38616.1 - 1.6e-62 211.2 2.6 2.9e-62 210.4 2.6 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDF38616.1 - 1.1e-47 160.7 0.3 3.6e-47 159.0 0.3 2.0 1 0 0 1 1 1 1 Thiolase, C-terminal domain 3HCDH_N PF02737.18 CDF38616.1 - 1.2e-46 158.8 0.2 2.9e-46 157.6 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 CDF38616.1 - 3.1e-38 131.5 0.0 1.7e-37 129.1 0.0 2.1 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 CDF38616.1 - 4.5e-23 81.7 0.1 1.8e-20 73.4 0.0 2.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 CDF38616.1 - 4e-20 72.6 0.0 1.7e-19 70.5 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ketoacyl-synt PF00109.26 CDF38616.1 - 0.0025 17.4 0.3 0.0095 15.5 0.3 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain NAD_binding_7 PF13241.6 CDF38616.1 - 0.015 15.8 0.2 0.22 11.9 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding HS1_rep PF02218.15 CDF38616.1 - 0.041 14.2 0.1 0.13 12.6 0.1 1.8 1 0 0 1 1 1 0 Repeat in HS1/Cortactin F420_oxidored PF03807.17 CDF38616.1 - 0.047 14.3 4.2 0.072 13.7 0.2 3.3 4 0 0 4 4 4 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CDF38616.1 - 0.16 12.3 0.6 5.6 7.2 0.1 2.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain PAP_fibrillin PF04755.12 CDF38617.1 - 3.2e-09 37.0 0.0 4.6e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 PAP_fibrillin baeRF_family12 PF18856.1 CDF38617.1 - 0.076 13.6 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 zf-RING_2 PF13639.6 CDF38618.1 - 3.5e-11 43.2 7.4 3.5e-11 43.2 7.4 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDF38618.1 - 3.9e-09 36.1 4.2 3.9e-09 36.1 4.2 2.3 4 0 0 4 4 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDF38618.1 - 2.6e-06 27.2 6.8 2.6e-06 27.2 6.8 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF38618.1 - 2.4e-05 24.5 13.3 5.3e-05 23.4 9.7 2.9 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDF38618.1 - 3.9e-05 23.6 1.2 3.9e-05 23.6 1.2 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDF38618.1 - 5.7e-05 22.9 6.4 5.7e-05 22.9 6.4 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDF38618.1 - 0.0013 18.8 4.9 0.012 15.8 4.9 2.2 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_5 PF14634.6 CDF38618.1 - 0.0058 16.6 9.6 0.012 15.5 5.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDF38618.1 - 0.2 11.3 7.7 0.49 10.1 7.7 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 CDF38618.1 - 0.31 11.0 15.1 0.13 12.1 7.0 3.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDF38618.1 - 0.79 9.8 10.0 0.27 11.3 5.8 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 CDF38618.1 - 1.2 9.3 10.9 0.14 12.3 6.3 1.8 2 0 0 2 2 2 0 RING-variant domain WD40 PF00400.32 CDF38619.1 - 1.7e-36 123.6 0.7 9.7e-06 26.2 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38619.1 - 4.7e-11 42.9 0.1 0.015 15.6 0.0 3.8 3 2 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Beta_helix PF13229.6 CDF38619.1 - 0.00096 19.0 0.0 0.0027 17.6 0.0 1.6 2 0 0 2 2 2 1 Right handed beta helix region Coatomer_WDAD PF04053.14 CDF38619.1 - 0.0018 17.4 0.3 0.22 10.5 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region Ge1_WD40 PF16529.5 CDF38619.1 - 0.0028 16.7 1.7 1.5 7.7 0.3 3.2 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDF38619.1 - 0.0064 15.2 0.9 1.8 7.1 0.1 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CDF38619.1 - 0.032 13.0 0.2 0.057 12.2 0.0 1.6 2 0 0 2 2 2 0 Nup133 N terminal like SGL PF08450.12 CDF38619.1 - 0.032 13.8 0.1 0.83 9.2 0.0 2.5 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DPPIV_N PF00930.21 CDF38619.1 - 0.052 12.3 0.1 5.7 5.6 0.0 2.8 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Fer2 PF00111.27 CDF38620.1 - 9.8e-12 44.7 0.2 1.7e-11 43.9 0.2 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain zf-RING_2 PF13639.6 CDF38622.1 - 0.00077 19.8 15.0 0.0023 18.2 15.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF38622.1 - 0.0092 16.3 11.1 0.0092 16.3 11.1 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDF38622.1 - 0.11 12.4 13.6 0.26 11.2 13.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDF38622.1 - 2.4 8.1 13.7 7 6.6 13.7 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF38622.1 - 4.2 7.2 14.2 0.42 10.4 8.5 2.3 2 0 0 2 2 2 0 RING-like zinc finger Pkinase PF00069.25 CDF38623.1 - 3.4e-58 197.1 0.0 4.8e-58 196.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38623.1 - 2.8e-37 128.4 0.0 4.1e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF38623.1 - 1.2e-07 30.9 0.0 2.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF38623.1 - 0.099 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Spem1 PF15670.5 CDF38623.1 - 0.1 12.1 0.0 0.52 9.8 0.0 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 DUF4914 PF16260.5 CDF38624.1 - 0.089 10.9 0.0 0.089 10.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) Yip1 PF04893.17 CDF38626.1 - 0.00016 21.4 0.3 0.00021 21.1 0.3 1.2 1 0 0 1 1 1 1 Yip1 domain Yip1 PF04893.17 CDF38627.1 - 0.00088 19.0 6.9 0.00088 19.0 6.9 2.1 1 1 2 3 3 3 1 Yip1 domain TMP-TENI PF02581.17 CDF38628.1 - 2.5e-25 88.9 0.1 3.2e-25 88.5 0.1 1.1 1 0 0 1 1 1 1 Thiamine monophosphate synthase Glycos_trans_3N PF02885.17 CDF38628.1 - 0.042 13.7 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Pkinase PF00069.25 CDF38630.1 - 3.9e-77 259.2 0.0 4.6e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38630.1 - 8.9e-33 113.7 0.0 1.2e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF38630.1 - 1.8e-05 23.9 0.0 2.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF38630.1 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CDF38630.1 - 0.088 11.8 0.0 0.18 10.9 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 MAT1 PF06391.13 CDF38633.1 - 5.2e-30 104.8 20.9 5.2e-30 104.8 20.9 1.7 2 0 0 2 2 2 1 CDK-activating kinase assembly factor MAT1 RHD3 PF05879.12 CDF38634.1 - 2e-60 204.8 0.0 3.4e-60 204.1 0.0 1.3 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 CDF38634.1 - 6.6e-05 23.0 0.2 0.001 19.1 0.0 2.3 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CDF38634.1 - 0.0017 18.4 0.0 0.0053 16.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CDF38634.1 - 0.0041 17.6 0.1 0.34 11.4 0.0 2.7 2 0 0 2 2 2 1 ABC transporter GBP PF02263.19 CDF38634.1 - 0.0043 16.3 0.1 0.012 14.8 0.0 1.7 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain HAUS-augmin3 PF14932.6 CDF38634.1 - 0.03 13.9 5.1 0.12 11.9 5.0 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 AAA_18 PF13238.6 CDF38634.1 - 0.05 14.1 0.0 0.19 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDF38634.1 - 0.15 12.4 0.7 0.44 10.9 0.3 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CDF38634.1 - 0.26 11.7 1.0 3 8.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain OmpH PF03938.14 CDF38634.1 - 1 9.7 9.2 1 9.7 7.0 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Plasmid_RAQPRD PF09686.10 CDF38634.1 - 1.5 9.1 5.0 3.5 7.9 5.0 1.6 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Atx10homo_assoc PF09759.9 CDF38635.1 - 1.6e-09 37.7 1.9 0.15 12.1 0.1 6.1 5 1 1 6 6 6 3 Spinocerebellar ataxia type 10 protein domain RYDR_ITPR PF01365.21 CDF38635.1 - 0.001 18.5 0.5 0.31 10.4 0.2 3.4 2 1 1 3 3 3 2 RIH domain DUF202 PF02656.15 CDF38636.1 - 0.0044 17.4 14.2 0.17 12.3 2.7 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF202) DUF2070 PF09843.9 CDF38636.1 - 0.81 7.9 8.7 0.96 7.7 8.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2304 PF10066.9 CDF38636.1 - 0.83 9.9 8.9 0.16 12.2 5.1 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Bromodomain PF00439.25 CDF38638.1 - 4.7e-16 58.6 0.0 1.1e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PIF1 PF05970.14 CDF38639.1 - 1.4e-78 264.6 0.0 3.3e-68 230.5 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF38639.1 - 2.4e-60 204.0 0.0 5.6e-60 202.8 0.0 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF38639.1 - 0.045 13.5 0.0 0.43 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Herpes_Helicase PF02689.14 CDF38639.1 - 0.075 11.0 0.0 0.12 10.3 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF38639.1 - 0.1 12.2 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus UvrD_C_2 PF13538.6 CDF38639.1 - 0.14 12.0 0.0 0.65 9.9 0.0 2.2 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain FAD_binding_8 PF08022.12 CDF38640.1 - 5.2e-19 68.4 0.0 1.1e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CDF38640.1 - 3.1e-15 56.6 0.0 7.6e-06 26.1 0.0 3.5 2 1 0 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CDF38640.1 - 1.8e-11 44.2 11.4 1.8e-11 44.2 11.4 2.8 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 CDF38640.1 - 6.9e-05 23.5 0.0 0.26 12.0 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF2069 PF09842.9 CDF38640.1 - 0.0027 17.9 1.2 0.0027 17.9 1.2 3.5 3 1 0 3 3 3 1 Predicted membrane protein (DUF2069) SapB_1 PF05184.15 CDF38640.1 - 0.0094 15.9 0.1 0.019 15.0 0.1 1.5 1 0 0 1 1 1 1 Saposin-like type B, region 1 FAD_binding_6 PF00970.24 CDF38640.1 - 0.011 16.1 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain DUF1870 PF08965.10 CDF38640.1 - 0.022 14.8 0.7 0.058 13.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) GCS PF03074.16 CDF38641.1 - 3e-141 471.0 0.0 4.1e-139 464.0 0.0 2.1 1 1 0 1 1 1 1 Glutamate-cysteine ligase GCS PF03074.16 CDF38642.1 - 1.7e-149 498.2 0.0 2.2e-149 497.8 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase CitMHS PF03600.16 CDF38644.1 - 6.4e-29 101.1 15.9 6.4e-29 101.1 15.9 2.3 1 1 1 2 2 2 1 Citrate transporter MotA_ExbB PF01618.16 CDF38644.1 - 0.91 9.3 3.4 3 7.6 0.1 3.0 3 0 0 3 3 3 0 MotA/TolQ/ExbB proton channel family Mito_carr PF00153.27 CDF38645.1 - 5.4e-36 122.4 1.4 4.8e-22 77.7 0.2 2.9 2 1 0 2 2 2 2 Mitochondrial carrier protein RETICULATA-like PF11891.8 CDF38645.1 - 0.074 12.9 0.2 1.4 8.8 0.0 2.4 3 0 0 3 3 3 0 Protein RETICULATA-related tRNA-synt_1c PF00749.21 CDF38648.1 - 5.4e-101 337.6 0.0 6.7e-101 337.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain VIT_2 PF13757.6 CDF38648.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain Ribosomal_L26 PF16906.5 CDF38649.1 - 3.8e-37 126.6 3.0 5e-37 126.2 3.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CDF38649.1 - 0.0033 17.3 2.5 0.0033 17.3 2.5 2.2 2 1 0 2 2 2 1 KOW motif DUF4121 PF13497.6 CDF38649.1 - 0.041 13.0 0.0 0.05 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) DUF1442 PF07279.11 CDF38649.1 - 0.12 11.6 0.5 0.16 11.2 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) Glycos_transf_2 PF00535.26 CDF38651.1 - 5.1e-10 39.4 0.0 8.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDF38651.1 - 0.0014 18.5 0.0 0.068 13.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.6 CDF38651.1 - 0.0049 16.6 0.0 0.0078 15.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family Thioredoxin PF00085.20 CDF38652.1 - 8.3e-29 99.6 0.0 1e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDF38652.1 - 1.2e-07 32.1 0.1 2.8e-07 30.9 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDF38652.1 - 1.6e-05 25.0 0.0 2.9e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CDF38652.1 - 3.6e-05 23.7 0.0 4.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CDF38652.1 - 8.5e-05 22.8 0.0 0.00029 21.1 0.0 1.7 1 1 1 2 2 2 1 Thioredoxin-like HyaE PF07449.11 CDF38652.1 - 0.047 13.7 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Redoxin PF08534.10 CDF38652.1 - 0.071 12.8 0.0 0.091 12.5 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_9 PF14595.6 CDF38652.1 - 0.18 11.6 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Fer4_13 PF13370.6 CDF38654.1 - 4.3e-15 56.0 0.7 1.2e-14 54.5 0.7 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain of Ferredoxin I Lactamase_B PF00753.27 CDF38654.1 - 0.00019 21.5 0.2 0.00047 20.2 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_5 PF14597.6 CDF38654.1 - 0.0009 18.8 0.0 0.0044 16.5 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Fer4_15 PF13459.6 CDF38654.1 - 0.04 14.7 0.6 0.095 13.5 0.1 1.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain Lactamase_B PF00753.27 CDF38661.1 - 0.12 12.4 0.0 0.15 12.1 0.0 1.0 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Uma2 PF05685.12 CDF38662.1 - 1.8e-16 60.1 0.3 1.3e-14 54.1 0.3 2.2 1 1 0 1 1 1 1 Putative restriction endonuclease FAM76 PF16046.5 CDF38662.1 - 0.00079 18.9 1.6 0.0012 18.3 1.6 1.4 1 0 0 1 1 1 1 FAM76 protein KASH_CCD PF14662.6 CDF38662.1 - 0.0023 17.8 1.6 0.0033 17.3 1.6 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF3552 PF12072.8 CDF38662.1 - 0.0025 17.3 8.6 0.0045 16.4 8.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) DUF641 PF04859.12 CDF38662.1 - 0.099 13.0 3.4 0.2 12.0 3.4 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 CDF38662.1 - 0.1 12.7 4.2 0.15 12.2 4.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PKcGMP_CC PF16808.5 CDF38662.1 - 0.11 12.4 12.4 0.24 11.3 1.8 2.8 1 1 2 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Atg14 PF10186.9 CDF38662.1 - 0.31 10.1 7.8 0.47 9.5 7.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_DNA_bd PF12329.8 CDF38662.1 - 0.53 10.3 18.3 0.058 13.4 4.2 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 CDF38662.1 - 0.86 8.4 7.9 1.3 7.8 7.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 CDF38662.1 - 1.3 8.3 6.0 1.9 7.7 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 CDF38662.1 - 4.2 7.2 9.9 2.2 8.1 5.1 2.4 1 1 1 2 2 2 0 Septum formation initiator Uma2 PF05685.12 CDF38663.1 - 1.9e-16 60.1 0.3 1.3e-14 54.1 0.3 2.2 1 1 0 1 1 1 1 Putative restriction endonuclease 60KD_IMP PF02096.20 CDF38663.1 - 4.6 7.1 5.2 8 6.3 5.2 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein EphA2_TM PF14575.6 CDF38664.1 - 0.042 14.7 0.0 7.7 7.5 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Pkinase_Tyr PF07714.17 CDF38666.1 - 8.8e-67 225.1 0.0 9.9e-67 224.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF38666.1 - 2.1e-56 191.2 0.0 2.5e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDF38666.1 - 5.2e-06 25.5 0.0 8.1e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF38666.1 - 0.00041 19.8 0.0 0.00072 18.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF38666.1 - 0.038 13.3 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRS1 PF04939.12 CDF38667.1 - 4e-40 137.3 0.1 4e-40 137.3 0.1 1.7 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) Myb_DNA-binding PF00249.31 CDF38668.1 - 7e-22 77.4 5.4 1.4e-11 44.4 1.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF38668.1 - 8.4e-18 64.4 5.6 1.9e-11 44.0 2.9 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_Cef PF11831.8 CDF38668.1 - 3.5e-15 56.2 6.0 3.5e-15 56.2 6.0 4.1 4 1 1 5 5 5 2 pre-mRNA splicing factor component SANT_DAMP1_like PF16282.5 CDF38668.1 - 0.12 12.6 0.2 0.33 11.2 0.2 1.8 1 1 0 1 1 1 0 SANT/Myb-like domain of DAMP1 FAM193_C PF15914.5 CDF38668.1 - 0.19 11.5 2.1 9.3 6.1 0.2 3.0 2 0 0 2 2 2 0 FAM193 family C-terminal DHBP_synthase PF00926.19 CDF38669.1 - 9.1e-83 276.5 0.0 1.2e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase GTP_cyclohydro2 PF00925.20 CDF38669.1 - 2.5e-68 228.8 0.0 3.9e-68 228.2 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II RTC PF01137.21 CDF38671.1 - 6.7e-47 159.5 0.0 8.1e-47 159.3 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Ribosomal_L39 PF00832.20 CDF38671.1 - 0.0076 15.9 1.3 0.021 14.4 1.3 1.8 1 0 0 1 1 1 1 Ribosomal L39 protein RFXA_RFXANK_bdg PF15289.6 CDF38671.1 - 0.1 13.0 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain ECH_2 PF16113.5 CDF38673.1 - 5e-106 355.0 0.0 5.9e-106 354.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDF38673.1 - 9.4e-16 57.9 0.0 1.5e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase MCM PF00493.23 CDF38674.1 - 1.8e-79 266.0 0.0 2.8e-79 265.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDF38674.1 - 1.1e-25 89.9 1.9 1.9e-25 89.1 1.9 1.4 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 CDF38674.1 - 4.6e-21 75.0 1.0 1.1e-20 73.7 1.0 1.6 1 1 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 CDF38674.1 - 1.4e-08 34.4 0.1 7.6e-06 25.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDF38674.1 - 1.1e-06 28.7 0.0 2.3e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDF38674.1 - 6.5e-06 26.0 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 CDF38674.1 - 0.0074 16.7 0.0 0.022 15.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF38674.1 - 0.052 13.9 0.0 0.24 11.8 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain Tcp11 PF05794.13 CDF38675.1 - 4.8e-28 98.4 0.5 4.8e-28 98.4 0.5 2.2 1 1 1 2 2 2 1 T-complex protein 11 tRNA-synt_2b PF00587.25 CDF38676.1 - 7.7e-32 110.7 0.0 7.9e-30 104.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDF38676.1 - 3.5e-18 65.5 0.2 7.2e-18 64.5 0.2 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 CDF38676.1 - 2.7e-07 30.5 0.0 7.5e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.14 CDF38676.1 - 3.5e-05 23.8 0.0 0.00012 22.1 0.0 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain NTP_transf_2 PF01909.23 CDF38677.1 - 1.5e-10 41.2 0.0 3.3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 CDF38677.1 - 2.8e-09 37.0 0.2 7.5e-09 35.7 0.2 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 CDF38677.1 - 3.7e-05 23.7 0.0 8.3e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Lysine_decarbox PF03641.14 CDF38678.1 - 5.6e-29 100.9 0.0 7e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CDF38678.1 - 3.7e-13 49.3 0.0 5e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 SLOG cluster4 family HOIP-UBA PF16678.5 CDF38678.1 - 0.02 14.9 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair Med19 PF10278.9 CDF38680.1 - 0.31 11.0 0.0 0.31 11.0 0.0 3.1 1 1 1 2 2 2 0 Mediator of RNA pol II transcription subunit 19 YGGT PF02325.17 CDF38681.1 - 1.4e-17 63.8 5.2 3.5e-17 62.6 5.0 1.7 2 0 0 2 2 2 1 YGGT family Sm_multidrug_ex PF06695.11 CDF38682.1 - 2.2e-28 99.3 6.2 4.1e-28 98.4 6.2 1.5 1 0 0 1 1 1 1 Putative small multi-drug export protein Internalin_N PF12354.8 CDF38682.1 - 0.14 12.3 0.1 0.39 10.8 0.1 1.7 1 0 0 1 1 1 0 Bacterial adhesion/invasion protein N terminal NnrU PF07298.11 CDF38683.1 - 4e-52 176.8 14.5 5.7e-52 176.3 14.5 1.1 1 0 0 1 1 1 1 NnrU protein PEMT PF04191.13 CDF38683.1 - 0.031 14.7 0.7 0.1 13.0 0.1 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase NDUFB11 PF17250.2 CDF38687.1 - 0.029 15.0 0.0 0.038 14.6 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase 11 kDa subunit DDE_1 PF03184.19 CDF38688.1 - 2.8e-13 49.9 0.0 3.7e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HEAT PF02985.22 CDF38689.1 - 1.3e-14 53.0 58.3 0.26 11.6 0.2 19.8 23 0 0 23 23 23 6 HEAT repeat HEAT_EZ PF13513.6 CDF38689.1 - 2.4e-12 47.1 60.7 0.0086 16.6 0.1 17.0 18 2 0 20 20 20 5 HEAT-like repeat CLASP_N PF12348.8 CDF38689.1 - 7.2e-11 42.1 0.7 0.0037 16.9 0.0 7.2 7 0 0 7 7 7 2 CLASP N terminal HEAT_2 PF13646.6 CDF38689.1 - 9e-10 38.8 41.6 0.31 11.5 0.1 12.8 13 1 1 14 14 14 6 HEAT repeats Cnd1 PF12717.7 CDF38689.1 - 1.1e-08 35.3 8.7 3.5 7.7 0.2 9.1 8 2 1 10 10 10 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDF38689.1 - 6.1e-08 33.2 0.0 1.5 9.5 0.0 7.5 8 2 2 10 10 10 2 Vacuolar 14 Fab1-binding region Cohesin_HEAT PF12765.7 CDF38689.1 - 0.02 15.2 0.7 0.36 11.2 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DUF937 PF06078.11 CDF38689.1 - 0.04 14.5 4.1 1.8 9.2 0.3 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF937) UME PF08064.13 CDF38689.1 - 0.088 12.7 4.1 67 3.5 0.0 6.0 7 0 0 7 7 7 0 UME (NUC010) domain WD40 PF00400.32 CDF38694.1 - 1.2e-70 231.6 31.9 4.8e-09 36.7 0.1 10.5 10 0 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38694.1 - 5.9e-21 74.6 10.4 0.00017 21.8 0.0 9.5 1 1 8 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain TIR_2 PF13676.6 CDF38694.1 - 1.5e-16 61.1 0.0 5e-16 59.4 0.0 2.0 1 0 0 1 1 1 1 TIR domain NB-ARC PF00931.22 CDF38694.1 - 1.1e-14 54.3 0.0 1.9e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Nup160 PF11715.8 CDF38694.1 - 1e-07 31.0 9.7 7.6 5.0 0.0 9.2 6 3 4 10 10 10 1 Nucleoporin Nup120/160 TIR PF01582.20 CDF38694.1 - 1.2e-07 31.7 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain Ge1_WD40 PF16529.5 CDF38694.1 - 2.6e-06 26.7 2.3 3.5 6.5 0.0 7.5 1 1 8 9 9 9 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF38694.1 - 0.00058 19.3 0.0 6.6 6.0 0.0 5.4 6 1 0 6 6 6 1 WD40-like domain AAA_22 PF13401.6 CDF38694.1 - 0.00064 20.0 0.0 0.0023 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain PQQ PF01011.21 CDF38694.1 - 0.0022 17.8 0.0 1.4e+02 2.7 0.0 6.4 8 0 0 8 8 8 0 PQQ enzyme repeat DUF4279 PF14106.6 CDF38694.1 - 0.15 12.3 1.0 1.6e+02 2.5 0.0 5.3 3 1 4 7 7 7 0 Domain of unknown function (DUF4279) WSC PF01822.19 CDF38694.1 - 0.18 12.0 0.0 0.45 10.7 0.0 1.6 1 0 0 1 1 1 0 WSC domain DUF727 PF05303.12 CDF38694.1 - 7.3 6.7 10.5 50 4.0 0.0 5.8 8 1 1 9 9 8 0 Protein of unknown function (DUF727) CBM9_2 PF16011.5 CDF38698.1 - 2.9e-08 33.7 0.0 2e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Carbohydrate-binding family 9 CBM9_1 PF06452.11 CDF38698.1 - 3.4e-07 30.4 0.0 6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate family 9 binding domain-like DUF2237 PF09996.9 CDF38700.1 - 2e-54 182.5 0.0 2.3e-54 182.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) Toxin_29 PF08116.11 CDF38702.1 - 0.096 12.7 2.0 0.096 12.7 2.0 3.0 3 0 0 3 3 3 0 PhTx neurotoxin family UPF0506 PF11703.8 CDF38702.1 - 4.6 7.7 24.6 7.1 7.1 9.6 2.6 1 1 1 2 2 2 0 UPF0506 APH PF01636.23 CDF38703.1 - 4.5e-09 36.6 0.0 1.1e-08 35.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family dCMP_cyt_deam_1 PF00383.23 CDF38705.1 - 4.7e-07 29.6 0.8 4.7e-07 29.6 0.8 1.0 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDF38705.1 - 3.9e-05 23.4 0.0 3.9e-05 23.4 0.0 1.0 1 0 0 1 1 1 1 MafB19-like deaminase DUF1487 PF07368.11 CDF38705.1 - 0.015 14.7 0.0 0.017 14.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) TIP49 PF06068.13 CDF38708.1 - 1.4e-25 90.2 0.0 1.9e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDF38708.1 - 1.3e-08 34.8 0.3 2.6e-08 33.9 0.1 1.5 2 0 0 2 2 2 1 TIP49 AAA-lid domain TIP49 PF06068.13 CDF38709.1 - 2.6e-35 122.3 1.2 3.1e-35 122.0 1.2 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain PaaX PF07848.12 CDF38709.1 - 0.065 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 PaaX-like protein Ribosomal_L35Ae PF01247.18 CDF38710.1 - 2.2e-17 63.0 0.5 2.4e-17 62.9 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae NTR PF01759.21 CDF38710.1 - 0.0063 16.3 0.0 0.0067 16.2 0.0 1.1 1 0 0 1 1 1 1 UNC-6/NTR/C345C module ERCC4 PF02732.15 CDF38712.1 - 2.7e-13 50.4 0.0 3.2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 ERCC4 domain Adaptin_N PF01602.20 CDF38717.1 - 1.3e-119 400.1 5.0 1.8e-119 399.7 5.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CDF38717.1 - 2.6e-55 186.9 4.0 2.4e-54 183.7 0.1 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDF38717.1 - 1.2e-13 51.3 8.0 1.2e-07 32.0 0.2 5.4 3 3 2 5 5 5 2 HEAT repeats B2-adapt-app_C PF09066.10 CDF38717.1 - 3.1e-08 33.7 0.0 7e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 CDF38717.1 - 1.2e-07 31.4 9.9 0.099 12.9 0.0 5.7 6 0 0 6 6 5 2 HEAT repeat CLASP_N PF12348.8 CDF38717.1 - 0.007 16.0 1.2 4.2 6.9 0.0 3.9 2 2 1 4 4 4 1 CLASP N terminal UNC45-central PF11701.8 CDF38717.1 - 0.014 15.4 1.1 0.79 9.7 0.1 3.2 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central DUF2791 PF10923.8 CDF38717.1 - 0.022 13.6 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) RTP1_C1 PF10363.9 CDF38717.1 - 0.025 14.7 0.7 0.53 10.5 0.1 3.2 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 CDF38717.1 - 0.026 15.0 1.2 17 6.1 0.0 5.2 5 1 1 6 6 6 0 HEAT-like repeat Arm PF00514.23 CDF38717.1 - 0.046 13.8 7.3 0.22 11.6 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Alpha_adaptinC2 PF02883.20 CDF38717.1 - 0.14 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Adaptin C-terminal domain CCDC142 PF14923.6 CDF38717.1 - 0.17 10.6 0.4 0.35 9.6 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil protein 142 DUF4487 PF14868.6 CDF38717.1 - 0.67 8.7 6.5 0.19 10.5 0.1 2.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4487) CoaE PF01121.20 CDF38718.1 - 8.4e-18 64.7 0.1 1e-17 64.4 0.1 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase NAD_binding_2 PF03446.15 CDF38720.1 - 2.7e-43 147.9 1.8 3.8e-43 147.4 1.8 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CDF38720.1 - 8.9e-32 109.9 0.2 1.6e-31 109.1 0.2 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CDF38720.1 - 1.7e-06 28.5 0.0 4.1e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CDF38720.1 - 3.3e-06 27.2 0.0 5.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CDF38720.1 - 3.1e-05 23.4 0.0 4.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CDF38720.1 - 0.00026 20.6 0.0 0.00043 20.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 CDF38720.1 - 0.0073 16.2 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydro_47 PF01532.20 CDF38722.1 - 6.8e-113 378.0 0.0 8.7e-113 377.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 BTB PF00651.31 CDF38723.1 - 2.6e-10 40.5 0.0 5.5e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CDF38723.1 - 0.001 19.1 2.1 0.0023 18.0 0.2 2.6 3 1 0 3 3 3 1 BTB And C-terminal Kelch T3SSipB PF16535.5 CDF38723.1 - 0.05 14.1 0.3 0.099 13.1 0.3 1.4 1 0 0 1 1 1 0 Type III cell invasion protein SipB UPF0449 PF15136.6 CDF38723.1 - 0.079 13.4 0.2 0.22 12.0 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF4372 PF14294.6 CDF38724.1 - 0.46 10.7 1.8 4.3 7.6 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4372) Cyt-b5 PF00173.28 CDF38725.1 - 8.4e-18 64.3 0.7 5.5e-16 58.5 0.1 2.4 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 CDF38725.1 - 9.1e-13 48.7 16.9 9.1e-13 48.7 16.9 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily PGI PF00342.19 CDF38726.1 - 4.5e-192 639.0 0.0 5.1e-192 638.8 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Ribosomal_L6 PF00347.23 CDF38727.1 - 3.6e-27 94.8 2.0 1.3e-17 64.3 1.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF1731 PF08338.11 CDF38728.1 - 6.3e-16 57.9 0.0 1.3e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 CDF38728.1 - 1.4e-12 47.6 0.1 6.4e-12 45.5 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CDF38728.1 - 9.5e-06 25.6 0.3 1.4e-05 25.1 0.3 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CDF38728.1 - 0.025 14.1 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family GDP_Man_Dehyd PF16363.5 CDF38728.1 - 0.029 13.8 0.0 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ACTL7A_N PF16840.5 CDF38728.1 - 0.078 13.0 0.3 2.5 8.2 0.0 2.9 3 0 0 3 3 3 0 Actin-like protein 7A N-terminus NAD_binding_4 PF07993.12 CDF38728.1 - 0.18 10.9 0.0 1.1 8.4 0.0 2.1 2 1 0 2 2 2 0 Male sterility protein Ribosomal_L23 PF00276.20 CDF38729.1 - 2.1e-13 50.5 0.5 2.6e-13 50.1 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 RIBIOP_C PF04950.12 CDF38733.1 - 4.8e-99 331.5 0.0 6.4e-99 331.0 0.0 1.2 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CDF38733.1 - 7.7e-11 41.9 0.0 2.4e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Pyridox_ox_2 PF12900.7 CDF38733.1 - 0.065 13.2 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Adeno_PIX PF03955.14 CDF38733.1 - 0.17 12.0 2.2 0.37 11.0 2.2 1.5 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Pkinase PF00069.25 CDF38734.1 - 1.8e-68 230.8 0.0 2.1e-68 230.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38734.1 - 3.1e-29 102.1 0.0 3.8e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF38734.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DXP_redisom_C PF08436.12 CDF38734.1 - 0.02 15.1 0.0 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain APH PF01636.23 CDF38734.1 - 0.022 14.7 0.1 0.048 13.6 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDF38734.1 - 0.023 13.7 0.1 0.042 12.8 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 CDF38734.1 - 0.039 13.6 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CDF38734.1 - 0.06 12.7 0.1 0.27 10.6 0.1 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TauE PF01925.19 CDF38735.1 - 3.3e-19 69.4 21.0 4e-19 69.2 21.0 1.1 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE BT1 PF03092.16 CDF38737.1 - 7.2e-96 321.5 12.9 1.7e-52 178.3 2.1 3.0 1 1 1 2 2 2 2 BT1 family Transgly PF00912.22 CDF38737.1 - 0.16 11.4 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase DUF981 PF06168.11 CDF38738.1 - 0.13 12.2 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF981) Galactosyl_T PF01762.21 CDF38739.1 - 0.013 15.3 0.0 0.035 13.9 0.0 1.7 1 1 0 1 1 1 0 Galactosyltransferase Bac_rhodopsin PF01036.18 CDF38739.1 - 0.091 12.3 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Bacteriorhodopsin-like protein O-FucT PF10250.9 CDF38740.1 - 0.051 13.3 0.0 0.72 9.5 0.0 2.3 1 1 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Stk19 PF10494.9 CDF38741.1 - 1.1e-17 64.6 0.2 1.7e-17 63.9 0.2 1.4 1 1 0 1 1 1 1 Serine-threonine protein kinase 19 CMS1 PF14617.6 CDF38742.1 - 2.8e-16 59.6 7.5 1e-15 57.8 7.5 1.8 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DUF1676 PF07898.13 CDF38742.1 - 0.012 15.6 1.2 0.048 13.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Uma2 PF05685.12 CDF38745.1 - 8.7e-16 57.9 0.0 1.2e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease DUF2415 PF10313.9 CDF38745.1 - 0.12 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Uma2 PF05685.12 CDF38747.1 - 4.1e-20 72.0 0.0 5.7e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease Borrelia_P83 PF05262.11 CDF38747.1 - 0.091 11.2 22.5 0.13 10.7 22.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF966 PF06136.13 CDF38747.1 - 0.64 9.7 11.7 0.88 9.2 11.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BAF1_ABF1 PF04684.13 CDF38747.1 - 1.1 8.2 13.6 1.5 7.8 13.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Red1 PF07964.11 CDF38747.1 - 2.5 6.2 15.3 3.5 5.7 15.3 1.1 1 0 0 1 1 1 0 Rec10 / Red1 SRP-alpha_N PF04086.13 CDF38747.1 - 5.7 6.8 21.7 8.4 6.2 21.7 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal GREB1 PF15782.5 CDF38747.1 - 6 3.8 9.4 7.5 3.5 9.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Acyl-CoA_dh_M PF02770.19 CDF38750.1 - 1.7e-16 60.2 0.0 2.9e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain ACOX PF01756.19 CDF38750.1 - 7.8e-09 35.3 0.1 2.6e-08 33.6 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 CDF38750.1 - 3.2e-06 27.4 4.9 5.4e-05 23.4 0.1 2.7 3 0 0 3 3 3 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDF38750.1 - 1.7e-05 25.4 0.0 4.5e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_ox_N PF14749.6 CDF38750.1 - 3.9e-05 24.2 0.0 7.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal DapB_C PF05173.14 CDF38750.1 - 0.087 12.9 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus NifU_N PF01592.16 CDF38750.1 - 0.11 12.6 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 NifU-like N terminal domain DUF563 PF04577.14 CDF38751.1 - 6.4e-12 46.0 2.1 7.4e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF563) Ephrin_rec_like PF07699.13 CDF38752.1 - 3.3e-56 186.8 122.7 5.9e-10 38.7 12.9 10.7 1 1 10 11 11 11 11 Putative ephrin-receptor like VSP PF03302.13 CDF38752.1 - 0.0016 17.4 77.5 0.71 8.7 17.3 4.6 1 1 3 4 4 4 4 Giardia variant-specific surface protein TNFR_c6 PF00020.18 CDF38752.1 - 0.0058 17.0 92.3 1.3 9.5 0.7 11.9 1 1 13 15 15 15 14 TNFR/NGFR cysteine-rich region GidB PF02527.15 CDF38753.1 - 1.5e-40 138.5 0.0 2.2e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_31 PF13847.6 CDF38753.1 - 0.00072 19.4 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF38753.1 - 0.0063 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PIF1 PF05970.14 CDF38756.1 - 6.1e-36 124.3 0.0 7.4e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase Herpes_Helicase PF02689.14 CDF38756.1 - 0.01 13.8 0.0 0.016 13.1 0.0 1.2 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF38756.1 - 0.029 14.2 0.1 0.11 12.4 0.1 2.0 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DEAD PF00270.29 CDF38757.1 - 4.3e-37 127.6 0.0 7.1e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF38757.1 - 4.5e-21 75.3 0.0 3.8e-20 72.3 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF38757.1 - 2.7e-05 24.2 0.0 5.9e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDF38757.1 - 0.026 13.7 0.0 0.085 12.0 0.0 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase Peptidase_M41 PF01434.18 CDF38758.1 - 0.0012 18.7 0.7 0.11 12.3 0.0 2.7 2 1 0 2 2 2 2 Peptidase family M41 Pirin PF02678.16 CDF38759.1 - 3.3e-32 110.7 0.2 8.1e-32 109.4 0.0 1.7 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 CDF38759.1 - 2.6e-30 104.9 0.1 1.9e-29 102.1 0.1 2.0 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 CDF38759.1 - 0.00051 19.7 2.3 0.16 11.7 0.2 2.4 2 0 0 2 2 2 2 Cupin domain RNA_pol_Rpb2_6 PF00562.28 CDF38760.1 - 6.5e-123 410.6 0.0 1e-122 410.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDF38760.1 - 3e-53 180.4 0.0 4.3e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 CDF38760.1 - 8.7e-33 112.6 0.7 1.8e-32 111.6 0.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 CDF38760.1 - 6.7e-22 77.5 0.1 2.1e-21 76.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CDF38760.1 - 2.6e-20 72.3 0.0 5.1e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 CDF38760.1 - 1.2e-19 70.7 0.1 4e-19 69.0 0.1 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 CDF38760.1 - 3.1e-10 40.4 0.2 8e-10 39.1 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Pkinase_Tyr PF07714.17 CDF38761.1 - 6e-49 166.6 0.0 7e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF38761.1 - 1.4e-47 162.3 0.0 1.7e-47 162.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDF38761.1 - 0.00012 21.0 0.0 0.0002 20.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF38761.1 - 0.00054 19.9 0.0 0.0059 16.6 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF38761.1 - 0.0047 16.3 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 CDF38761.1 - 0.035 13.7 0.0 0.062 12.9 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDF38761.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M14 PF00246.24 CDF38763.1 - 1.9e-25 90.2 0.0 1.2e-24 87.6 0.0 2.1 2 0 0 2 2 2 1 Zinc carboxypeptidase AstE_AspA PF04952.14 CDF38763.1 - 0.11 11.6 0.0 0.3 10.1 0.0 1.8 2 0 0 2 2 2 0 Succinylglutamate desuccinylase / Aspartoacylase family AAA_2 PF07724.14 CDF38764.1 - 1e-39 136.4 0.0 1.7e-39 135.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CDF38764.1 - 3.1e-14 53.5 0.0 6.1e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CDF38764.1 - 5e-13 48.9 0.1 1.1e-12 47.8 0.1 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CDF38764.1 - 6.5e-07 29.4 0.0 2.4e-06 27.6 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CDF38764.1 - 1.1e-06 27.9 0.1 2e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain RuvB_N PF05496.12 CDF38764.1 - 3.2e-06 27.0 0.1 0.00016 21.4 0.1 3.0 3 1 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF38764.1 - 4.2e-05 23.8 0.1 0.00022 21.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDF38764.1 - 0.00014 21.3 0.1 0.54 9.6 0.0 3.1 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDF38764.1 - 0.00029 20.4 0.1 0.00084 18.9 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDF38764.1 - 0.00039 20.2 0.0 0.00086 19.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 CDF38764.1 - 0.00069 19.3 0.0 0.035 13.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 CDF38764.1 - 0.00086 19.7 0.7 0.0053 17.2 0.1 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 CDF38764.1 - 0.0021 18.6 0.0 0.0048 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 CDF38764.1 - 0.0034 17.3 0.0 0.0064 16.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial dnaA protein AAA_14 PF13173.6 CDF38764.1 - 0.0049 16.9 0.0 0.0087 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 CDF38764.1 - 0.006 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 CDF38764.1 - 0.01 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDF38764.1 - 0.01 16.2 0.0 0.028 14.8 0.0 1.7 2 0 0 2 2 1 0 RNA helicase NACHT PF05729.12 CDF38764.1 - 0.013 15.4 0.0 0.23 11.3 0.0 2.7 3 0 0 3 3 3 0 NACHT domain DUF87 PF01935.17 CDF38764.1 - 0.029 14.5 0.1 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 CDF38764.1 - 0.031 13.2 0.2 0.064 12.2 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain KAP_NTPase PF07693.14 CDF38764.1 - 0.045 13.0 0.1 6.6 5.9 0.0 2.3 1 1 1 2 2 2 0 KAP family P-loop domain AAA_28 PF13521.6 CDF38764.1 - 0.061 13.6 0.4 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CDF38764.1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDF38764.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDF38764.1 - 0.12 12.7 0.2 0.86 9.9 0.1 2.3 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDF38764.1 - 0.15 11.8 0.2 0.38 10.5 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MoaC PF01967.21 CDF38768.1 - 3.2e-49 166.5 0.9 3.7e-49 166.3 0.9 1.0 1 0 0 1 1 1 1 MoaC family HCV_env PF01539.17 CDF38768.1 - 0.055 13.2 0.1 0.079 12.6 0.1 1.2 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 BPL_LplA_LipB PF03099.19 CDF38769.1 - 3e-06 27.2 0.0 1.7e-05 24.8 0.0 2.0 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family PseudoU_synth_1 PF01416.20 CDF38770.1 - 8.6e-26 90.5 0.0 4.4e-18 65.7 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase Peptidase_M28 PF04389.17 CDF38773.1 - 2.4e-35 122.1 0.0 4.1e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CDF38773.1 - 3.3e-07 30.2 0.1 6.2e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 MFS_1 PF07690.16 CDF38774.1 - 1.5e-20 73.4 30.3 1.5e-20 73.4 30.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Cpn10 PF00166.21 CDF38778.1 - 1.3e-28 98.9 0.0 1.4e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit VID27 PF08553.10 CDF38779.1 - 4.7e-103 345.0 0.3 7.2e-103 344.4 0.3 1.3 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_PH PF17747.1 CDF38779.1 - 2.6e-05 24.4 0.9 0.0018 18.5 0.5 3.0 3 0 0 3 3 3 1 VID27 PH-like domain VID27_N PF17748.1 CDF38779.1 - 0.0069 16.3 0.7 0.036 13.9 0.0 2.4 2 0 0 2 2 2 1 VID27 N-terminal region ThaI PF15514.6 CDF38779.1 - 0.085 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease ThaI GTP_EFTU PF00009.27 CDF38780.1 - 1.8e-33 115.7 0.1 1.1e-32 113.1 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CDF38780.1 - 3.7e-20 72.0 0.0 1.1e-19 70.5 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 CDF38780.1 - 1.2e-14 54.0 1.3 1.7e-14 53.5 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 CDF38780.1 - 3e-11 43.6 9.8 8e-08 32.6 0.9 3.5 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF38780.1 - 1e-07 32.0 0.3 1e-06 28.8 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 CDF38780.1 - 0.0011 19.2 0.0 0.0025 18.0 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MFS_1 PF07690.16 CDF38781.1 - 2.6e-42 145.0 28.3 2.6e-42 145.0 28.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDF38781.1 - 3.8e-11 42.5 5.6 3.8e-11 42.5 5.6 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 CDF38781.1 - 2e-06 26.4 18.1 0.022 13.1 0.1 4.1 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 CDF38781.1 - 0.0014 18.0 2.5 0.0014 18.0 2.5 3.1 2 1 2 4 4 4 1 Uncharacterised MFS-type transporter YbfB RibD_C PF01872.17 CDF38782.1 - 2.5e-34 118.9 0.0 4.7e-34 118.0 0.0 1.5 1 1 0 1 1 1 1 RibD C-terminal domain Ald_Xan_dh_C2 PF02738.18 CDF38784.1 - 7.6e-180 599.0 0.1 1e-179 598.5 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 CDF38784.1 - 5.5e-42 143.4 0.2 2.2e-41 141.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 CDF38784.1 - 1.8e-28 99.1 0.5 5e-28 97.6 0.5 1.8 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 CDF38784.1 - 2e-27 95.0 0.0 4.3e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.17 CDF38784.1 - 5.6e-20 71.4 0.0 1.5e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.27 CDF38784.1 - 1.6e-05 24.8 0.8 1.6e-05 24.8 0.8 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.9 CDF38784.1 - 0.035 13.9 3.0 0.097 12.5 3.0 1.8 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B RIF5_SNase_2 PF18189.1 CDF38785.1 - 0.17 11.7 0.0 7.2 6.4 0.0 2.3 2 0 0 2 2 2 0 TbRIF5 SNase domain 2 Malectin PF11721.8 CDF38786.1 - 1.2e-15 58.0 0.0 7.1e-05 23.0 0.0 3.4 3 0 0 3 3 3 3 Malectin domain GrpE PF01025.19 CDF38787.1 - 1.2e-43 148.6 0.0 1.5e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 GrpE EI24 PF07264.11 CDF38788.1 - 1.2e-05 25.6 0.1 0.00016 22.0 0.1 2.1 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-UBP PF02148.19 CDF38791.1 - 1.3e-16 60.6 3.8 2.3e-16 59.9 3.8 1.3 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Ribosomal_S19 PF00203.21 CDF38792.1 - 3.2e-33 113.4 0.3 4.3e-33 113.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 DUF5055 PF16478.5 CDF38792.1 - 0.11 12.8 0.5 0.41 10.9 0.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5055) Ufm1 PF03671.14 CDF38793.1 - 3.9e-43 145.4 0.2 4.4e-43 145.2 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein DUF2997 PF11211.8 CDF38794.1 - 6.9e-18 64.2 1.2 9.9e-18 63.7 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2997) NifU PF01106.17 CDF38796.1 - 5.1e-27 93.8 4.4 8.1e-19 67.5 0.2 2.9 2 1 0 2 2 2 2 NifU-like domain Tic22 PF04278.12 CDF38796.1 - 0.091 12.1 0.5 7.4 5.9 0.1 2.4 3 0 0 3 3 3 0 Tic22-like family GIY-YIG PF01541.24 CDF38796.1 - 0.22 11.9 0.0 0.34 11.2 0.0 1.3 1 0 0 1 1 1 0 GIY-YIG catalytic domain adh_short_C2 PF13561.6 CDF38797.1 - 2.3e-81 272.8 0.1 2.6e-81 272.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDF38797.1 - 7.2e-22 77.8 0.0 9.5e-22 77.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Enoyl_reductase PF12241.8 CDF38797.1 - 9.8e-06 25.1 0.0 0.0021 17.4 0.1 2.1 1 1 1 2 2 2 2 Trans-2-enoyl-CoA reductase catalytic region IF-2B PF01008.17 CDF38798.1 - 2.3e-10 40.2 1.6 3.3e-10 39.7 1.0 1.3 1 1 0 1 1 1 1 Initiation factor 2 subunit family Acetyltransf_CG PF14542.6 CDF38798.1 - 0.012 15.7 0.3 0.034 14.3 0.1 1.8 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_7 PF13508.7 CDF38798.1 - 0.059 13.8 0.1 0.13 12.7 0.1 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Glycos_transf_4 PF00953.21 CDF38799.1 - 4.5e-36 124.2 13.7 1.4e-35 122.7 13.7 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 4 rve PF00665.26 CDF38803.1 - 4.3e-13 49.5 0.0 8.9e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF38803.1 - 4.2e-08 33.2 1.0 1.1e-07 31.8 1.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DUF4218 PF13960.6 CDF38805.1 - 0.00022 20.8 0.0 0.00047 19.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) zf-Tim10_DDP PF02953.15 CDF38807.1 - 4.9e-18 64.5 4.0 4.9e-18 64.5 4.0 1.6 1 1 0 1 1 1 1 Tim10/DDP family zinc finger c-SKI_SMAD_bind PF08782.10 CDF38807.1 - 0.069 13.4 0.6 0.069 13.4 0.6 1.4 2 0 0 2 2 2 0 c-SKI Smad4 binding domain ArAE_2_N PF10337.9 CDF38807.1 - 0.096 11.7 1.4 0.12 11.4 1.4 1.0 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal TraB PF01963.17 CDF38808.1 - 1.2e-11 45.1 0.2 3.8e-11 43.4 0.2 1.8 1 1 0 1 1 1 1 TraB family YfdX PF10938.8 CDF38808.1 - 0.019 14.9 0.8 0.037 14.0 0.8 1.4 1 0 0 1 1 1 0 YfdX protein Ldh_1_C PF02866.18 CDF38812.1 - 0.18 11.7 0.8 0.29 11.0 0.8 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ribosomal_L1 PF00687.21 CDF38813.1 - 1.5e-33 116.3 0.0 1.8e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family CAP_N PF01213.19 CDF38813.1 - 2 7.8 3.8 3.2 7.2 3.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal LRR_8 PF13855.6 CDF38814.1 - 6.6e-23 80.3 13.4 6.6e-09 35.4 0.5 4.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CDF38814.1 - 4.1e-19 68.4 16.4 1.3e-05 25.4 0.7 5.9 3 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDF38814.1 - 2e-06 27.6 14.2 9.5 7.2 0.0 7.7 8 0 0 8 8 8 3 Leucine Rich Repeat RsmF_methylt_CI PF17126.5 CDF38814.1 - 0.00061 19.8 0.0 8.3 6.5 0.0 3.9 4 0 0 4 4 4 1 RsmF rRNA methyltransferase first C-terminal domain LRR_6 PF13516.6 CDF38814.1 - 0.018 15.1 11.9 21 5.5 0.0 6.5 8 0 0 8 8 8 0 Leucine Rich repeat CREPT PF16566.5 CDF38814.1 - 0.12 12.5 0.4 67 3.6 0.1 3.7 2 2 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour tRNA-synt_1 PF00133.22 CDF38815.1 - 1.9e-196 654.0 0.0 2e-195 650.5 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDF38815.1 - 4.5e-36 124.1 0.0 9e-36 123.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDF38815.1 - 5.2e-13 48.5 1.0 3.6e-05 22.7 0.1 3.8 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CDF38815.1 - 9.1e-09 35.1 1.6 8.5e-06 25.4 0.0 2.8 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 CDF38815.1 - 0.15 11.3 0.1 3.1 7.0 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Val_tRNA-synt_C PF10458.9 CDF38815.1 - 3.4 8.0 16.8 0.032 14.5 2.9 3.1 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm GDA1_CD39 PF01150.17 CDF38817.1 - 4.1e-41 141.0 0.0 6.9e-34 117.2 0.0 2.5 1 1 1 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 CDF38818.1 - 6.1e-10 39.0 0.0 8.2e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family RNase_H2-Ydr279 PF09468.10 CDF38819.1 - 1.9e-08 34.6 0.5 7.5e-08 32.7 0.5 2.1 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 CDF38819.1 - 0.017 15.4 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain LysR_substrate PF03466.20 CDF38821.1 - 2.2e-06 27.2 0.0 3e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain NMT1 PF09084.11 CDF38821.1 - 5.7e-06 26.4 0.0 1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 CDF38821.1 - 0.00024 20.8 0.0 0.00031 20.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein His_Phos_1 PF00300.22 CDF38822.1 - 1.3e-14 54.3 0.2 1.1e-12 48.0 0.2 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TPT PF03151.16 CDF38825.1 - 6.1e-28 98.0 21.8 7.4e-28 97.7 21.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDF38825.1 - 1.4e-09 38.2 29.4 0.00011 22.4 7.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CDF38825.1 - 6.1e-08 32.2 20.2 8.2e-08 31.8 20.2 1.2 1 0 0 1 1 1 1 UAA transporter family Wzy_C PF04932.15 CDF38825.1 - 0.26 10.9 0.1 0.26 10.9 0.1 3.6 1 1 1 2 2 2 0 O-Antigen ligase NADH-u_ox-rdase PF10785.9 CDF38825.1 - 0.4 11.4 3.3 1.4 9.7 0.0 3.0 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit TMEM234 PF10639.9 CDF38825.1 - 2.7 8.1 10.4 0.48 10.5 1.0 3.3 3 1 2 5 5 5 0 Putative transmembrane family 234 PEMT PF04191.13 CDF38826.1 - 3.6e-47 159.1 9.8 3.2e-26 91.8 0.8 2.5 2 0 0 2 2 2 2 Phospholipid methyltransferase Fzo_mitofusin PF04799.13 CDF38826.1 - 0.14 11.7 0.1 0.14 11.7 0.1 1.7 2 0 0 2 2 2 0 fzo-like conserved region ICMT PF04140.14 CDF38826.1 - 0.34 11.4 3.0 1.3 9.5 0.2 2.9 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF563 PF04577.14 CDF38828.1 - 7.2e-20 72.0 0.0 1.3e-19 71.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) COPI_C PF06957.11 CDF38829.1 - 3.9e-06 25.9 0.2 6.5e-06 25.2 0.2 1.3 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Sel1 PF08238.12 CDF38831.1 - 8.7e-20 70.7 3.7 0.00014 22.5 0.0 4.2 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.6 CDF38831.1 - 1.8e-06 28.2 12.8 0.88 10.3 0.1 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat NSF PF02071.20 CDF38831.1 - 0.0015 18.8 1.4 22 6.4 0.1 4.0 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_17 PF13431.6 CDF38831.1 - 0.0094 16.3 0.5 28 5.4 0.3 4.0 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38831.1 - 0.052 14.4 19.1 11 7.2 0.8 4.6 2 2 1 4 4 4 0 Tetratricopeptide repeat HEAT_2 PF13646.6 CDF38831.1 - 0.12 12.8 12.5 2.6 8.5 3.8 2.6 1 1 2 3 3 3 0 HEAT repeats TPR_2 PF07719.17 CDF38831.1 - 0.74 10.1 8.8 12 6.3 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38831.1 - 9.1 7.0 17.9 2.4 8.9 4.1 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF38831.1 - 9.8 6.2 7.0 15 5.6 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat YjeF_N PF03853.15 CDF38833.1 - 4.3e-24 85.3 0.0 7.6e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus SLT PF01464.20 CDF38834.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain Peptidase_S9 PF00326.21 CDF38836.1 - 1.5e-10 40.9 0.1 1.5e-09 37.7 0.0 2.2 2 1 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDF38836.1 - 7.2e-09 35.3 0.2 3.5e-05 23.2 0.2 2.4 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF38836.1 - 7.8e-07 29.0 0.0 0.00087 19.0 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDF38836.1 - 0.013 15.3 0.0 14 5.4 0.0 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF829 PF05705.14 CDF38836.1 - 0.14 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Humanin PF15040.6 CDF38836.1 - 0.66 9.5 4.2 2.9 7.4 0.3 2.6 2 0 0 2 2 2 0 Humanin family Pkinase PF00069.25 CDF38837.1 - 1.7e-37 129.2 0.0 5.4e-32 111.2 0.0 2.5 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38837.1 - 1.5e-20 73.6 0.0 6.5e-17 61.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase cobW PF02492.19 CDF38838.1 - 1.5e-41 141.9 0.1 2.1e-41 141.5 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CDF38838.1 - 6.2e-06 26.0 0.0 1.3e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Viral_helicase1 PF01443.18 CDF38838.1 - 0.0016 18.2 0.1 0.0028 17.4 0.1 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CDF38838.1 - 0.0057 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF38838.1 - 0.0059 16.3 0.2 0.014 15.1 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CDF38838.1 - 0.015 15.5 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDF38838.1 - 0.019 15.3 0.1 0.069 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDF38838.1 - 0.09 12.7 0.1 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Med13_N PF11597.8 CDF38838.1 - 0.13 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal AAA_18 PF13238.6 CDF38838.1 - 0.15 12.6 0.0 0.51 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDF38838.1 - 0.17 11.0 0.1 0.31 10.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) GTP_EFTU PF00009.27 CDF38838.1 - 0.17 11.4 0.1 18 4.8 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDF38838.1 - 0.19 11.8 0.1 0.34 11.0 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase eIF-1a PF01176.19 CDF38839.1 - 1.4e-21 76.0 0.1 2.2e-21 75.4 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Adap_comp_sub PF00928.21 CDF38841.1 - 9e-28 97.4 0.0 1.4e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDF38841.1 - 0.0012 18.8 0.1 0.0019 18.2 0.1 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF563 PF04577.14 CDF38844.1 - 0.053 13.6 0.1 0.077 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF563) bZIP_Maf PF03131.17 CDF38844.1 - 0.09 13.3 15.6 0.1 13.1 14.3 1.9 1 1 0 1 1 1 0 bZIP Maf transcription factor DUF4407 PF14362.6 CDF38844.1 - 0.13 11.6 3.0 0.17 11.2 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) bZIP_1 PF00170.21 CDF38844.1 - 0.19 11.9 17.5 0.066 13.3 14.8 1.7 2 0 0 2 2 2 0 bZIP transcription factor UPF0242 PF06785.11 CDF38844.1 - 0.22 11.6 9.8 0.31 11.1 9.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Golgin_A5 PF09787.9 CDF38844.1 - 1.4 8.3 15.5 1.9 7.9 15.5 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Bystin PF05291.11 CDF38845.1 - 3.1e-117 391.0 0.1 4.5e-117 390.5 0.1 1.2 1 0 0 1 1 1 1 Bystin MIF4G PF02854.19 CDF38846.1 - 1.1e-44 152.6 0.0 3.2e-20 72.7 0.0 4.3 4 0 0 4 4 4 4 MIF4G domain Upf2 PF04050.14 CDF38846.1 - 9.8e-18 65.2 7.4 9.8e-18 65.2 7.4 3.2 2 1 0 2 2 2 1 Up-frameshift suppressor 2 zf-HC5HC2H PF13771.6 CDF38847.1 - 3.2e-09 36.9 5.5 3.2e-09 36.9 5.5 2.3 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CDF38847.1 - 1.8e-07 31.3 3.3 1.8e-07 31.3 3.3 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain DUF4004 PF13171.6 CDF38847.1 - 0.088 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4004) HMG_box PF00505.19 CDF38847.1 - 0.094 13.2 0.2 0.19 12.1 0.2 1.5 1 0 0 1 1 1 0 HMG (high mobility group) box HMG_box_2 PF09011.10 CDF38847.1 - 0.096 13.3 0.2 0.22 12.1 0.2 1.5 1 0 0 1 1 1 0 HMG-box domain zf-C3HC4_2 PF13923.6 CDF38847.1 - 0.11 12.4 2.0 0.33 10.8 2.0 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF38847.1 - 0.19 11.5 6.7 0.15 11.8 4.0 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 CDF38847.1 - 1.5 9.1 8.3 0.081 13.2 1.6 2.3 3 0 0 3 3 3 0 RING-H2 zinc finger domain DWNN PF08783.11 CDF38848.1 - 2.4e-24 85.4 0.1 3.9e-24 84.7 0.1 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CDF38848.1 - 3.7e-10 39.4 4.0 6.2e-10 38.7 4.0 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CDF38848.1 - 0.00021 21.2 1.9 0.00037 20.4 1.9 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 CDF38848.1 - 0.0029 17.5 0.1 0.0076 16.2 0.1 1.7 1 0 0 1 1 1 1 Zinc knuckle WD40 PF00400.32 CDF38850.1 - 9.3e-27 92.8 21.3 1.2e-06 29.2 2.8 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat TIR_2 PF13676.6 CDF38850.1 - 7.3e-17 62.1 0.0 5.9e-16 59.1 0.0 2.5 2 0 0 2 2 2 1 TIR domain NB-ARC PF00931.22 CDF38850.1 - 1.2e-16 60.7 0.0 2.5e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF38850.1 - 4.3e-08 33.2 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF38850.1 - 0.00039 20.7 3.6 2.4 8.5 0.1 4.4 1 1 4 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 CDF38850.1 - 0.00077 19.7 0.0 0.0022 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Nup160 PF11715.8 CDF38850.1 - 0.00078 18.2 1.7 11 4.5 0.0 4.8 4 1 0 5 5 5 1 Nucleoporin Nup120/160 TIR-like PF10137.9 CDF38850.1 - 0.069 13.1 0.0 0.24 11.3 0.0 2.0 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain E1_dh PF00676.20 CDF38855.1 - 1.3e-87 293.5 0.3 1.7e-87 293.1 0.3 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.21 CDF38855.1 - 4.9e-06 25.7 0.0 1e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain TPP_enzyme_C PF02775.21 CDF38855.1 - 0.00049 19.9 0.6 0.0021 17.9 0.6 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CDF38855.1 - 0.041 13.1 0.2 0.18 11.0 0.2 1.7 1 1 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase zf-C2H2_11 PF16622.5 CDF38858.1 - 2.2e-06 27.3 14.3 0.0007 19.3 0.0 3.2 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2 PF00096.26 CDF38858.1 - 5.9e-05 23.3 38.2 0.0011 19.3 7.5 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF38858.1 - 0.0022 18.7 39.3 0.33 11.9 6.6 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf_UBZ PF18439.1 CDF38858.1 - 0.0049 16.4 7.4 0.58 9.8 0.1 3.4 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger zf-H2C2_2 PF13465.6 CDF38858.1 - 0.013 15.9 0.5 0.013 15.9 0.5 6.1 8 1 0 8 8 8 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDF38858.1 - 0.71 10.2 0.0 0.71 10.2 0.0 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Bac_transf PF02397.16 CDF38863.1 - 0.021 14.4 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial sugar transferase Alpha_GJ PF03229.13 CDF38863.1 - 0.29 11.7 0.8 0.43 11.1 0.8 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J Pkinase PF00069.25 CDF38864.1 - 1.3e-48 165.7 0.0 1.8e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38864.1 - 3.9e-18 65.7 0.0 1.5e-17 63.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF38864.1 - 1.3e-05 24.6 0.0 3.2e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF38864.1 - 0.00019 20.9 0.0 0.00036 19.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF38864.1 - 0.00068 18.5 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CDF38864.1 - 0.056 12.4 0.0 0.074 12.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase PF00069.25 CDF38865.1 - 2.6e-50 171.2 0.0 3.3e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF38865.1 - 9.2e-22 77.6 0.0 6.5e-21 74.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF38865.1 - 0.0021 16.9 0.0 0.0031 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDF38865.1 - 0.0027 17.1 0.0 0.032 13.5 0.0 2.3 2 1 0 2 2 2 1 Kinase-like ABC1 PF03109.16 CDF38868.1 - 7e-36 123.0 0.0 1.2e-35 122.2 0.0 1.4 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.11 CDF38868.1 - 0.051 13.2 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) Aldedh PF00171.22 CDF38871.1 - 7.3e-147 489.6 0.4 2.3e-146 488.0 0.4 1.6 1 1 0 1 1 1 1 Aldehyde dehydrogenase family DUF3283 PF11686.8 CDF38871.1 - 0.031 14.1 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3283) DUF126 PF01989.16 CDF38871.1 - 0.2 11.5 1.2 1.2 9.0 1.2 2.3 1 1 0 1 1 1 0 Aconitase X swivel domain Herpes_DNAp_acc PF04929.12 CDF38872.1 - 0.039 12.9 3.2 0.02 13.9 1.3 1.4 1 1 0 1 1 1 0 Herpes DNA replication accessory factor Raptor_N PF14538.6 CDF38876.1 - 3.3e-50 169.9 0.0 5.2e-50 169.2 0.0 1.3 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 CDF38876.1 - 4.1e-10 40.1 6.6 0.041 14.8 0.0 6.4 6 0 0 6 6 6 2 WD domain, G-beta repeat HEAT PF02985.22 CDF38876.1 - 0.0011 19.0 3.1 0.21 12.0 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat ANAPC4_WD40 PF12894.7 CDF38876.1 - 0.0089 16.3 0.0 35 4.8 0.0 3.8 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 CDF38876.1 - 0.011 16.2 0.8 0.068 13.6 0.0 2.6 3 0 0 3 3 3 0 HEAT repeats Peptidase_C14 PF00656.22 CDF38876.1 - 0.058 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Caspase domain Adaptin_N PF01602.20 CDF38876.1 - 0.28 9.7 0.0 0.47 8.9 0.0 1.2 1 0 0 1 1 1 0 Adaptin N terminal region Abhydrolase_6 PF12697.7 CDF38878.1 - 1.2e-22 81.6 0.8 1.4e-22 81.4 0.8 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF38878.1 - 1.4e-16 60.5 0.0 7.8e-16 58.1 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF38878.1 - 2.8e-14 53.4 0.0 7.6e-13 48.7 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 CDF38878.1 - 1.1e-05 25.2 0.0 0.00013 21.7 0.0 2.0 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DLH PF01738.18 CDF38878.1 - 1.3e-05 24.8 0.0 0.0013 18.3 0.0 2.4 2 1 0 2 2 2 1 Dienelactone hydrolase family Ser_hydrolase PF06821.13 CDF38878.1 - 4.1e-05 23.5 0.0 7.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase DUF3530 PF12048.8 CDF38878.1 - 0.00034 20.1 0.0 0.0005 19.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) Thioesterase PF00975.20 CDF38878.1 - 0.00058 20.0 0.0 0.006 16.7 0.0 2.0 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_3 PF07859.13 CDF38878.1 - 0.00062 19.7 0.0 0.031 14.1 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.14 CDF38878.1 - 0.0014 17.4 0.0 0.0053 15.5 0.0 1.7 2 0 0 2 2 2 1 Ndr family Abhydrolase_5 PF12695.7 CDF38878.1 - 0.0024 17.6 0.0 0.095 12.5 0.0 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Acyl_transf_1 PF00698.21 CDF38878.1 - 0.0029 17.2 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 2 Acyl transferase domain Peptidase_S9 PF00326.21 CDF38878.1 - 0.0029 17.1 0.0 0.12 11.8 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CDF38878.1 - 0.019 13.9 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF915 PF06028.11 CDF38878.1 - 0.1 11.9 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) FAD_binding_3 PF01494.19 CDF38882.1 - 1.2e-15 57.7 0.4 3.5e-07 29.8 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 CDF38882.1 - 0.0061 15.6 0.4 0.019 14.0 0.0 1.9 2 0 0 2 2 2 1 Squalene epoxidase Trp_halogenase PF04820.14 CDF38882.1 - 0.042 12.7 0.0 0.74 8.6 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase RRM_1 PF00076.22 CDF38884.1 - 4.7e-15 55.2 0.0 6.5e-08 32.3 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.13 CDF38884.1 - 0.0027 17.6 0.0 0.0054 16.6 0.0 1.4 1 0 0 1 1 1 1 SPOC domain RRM_occluded PF16842.5 CDF38884.1 - 0.15 11.9 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif VWA_2 PF13519.6 CDF38887.1 - 1.4e-17 64.3 0.1 6e-17 62.2 0.1 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain UIM PF02809.20 CDF38887.1 - 0.00025 20.7 10.7 0.0091 15.9 2.4 3.1 2 1 0 2 2 2 2 Ubiquitin interaction motif Ssl1 PF04056.14 CDF38887.1 - 0.00029 20.7 0.2 0.00041 20.2 0.2 1.2 1 0 0 1 1 1 1 Ssl1-like RAP80_UIM PF18282.1 CDF38887.1 - 0.073 12.8 1.3 3.6 7.4 0.3 2.5 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif THF_DHG_CYH_C PF02882.19 CDF38888.1 - 3e-67 224.9 0.4 4.1e-67 224.5 0.4 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CDF38888.1 - 1.8e-38 131.4 0.1 3.1e-38 130.6 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 CDF38888.1 - 0.013 14.4 0.3 0.021 13.8 0.3 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Kinesin PF00225.23 CDF38889.1 - 3e-76 256.5 0.1 1.3e-75 254.4 0.1 2.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDF38889.1 - 0.056 13.4 0.0 0.056 13.4 0.0 3.8 5 0 0 5 5 5 0 Microtubule binding APH PF01636.23 CDF38892.1 - 2.4e-09 37.5 1.6 3.7e-09 36.9 1.6 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF38892.1 - 0.0086 15.7 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 CDF38892.1 - 0.039 13.3 0.0 0.22 10.8 0.0 1.9 1 1 0 1 1 1 0 Ecdysteroid kinase acVLRF1 PF18859.1 CDF38893.1 - 0.076 13.3 0.0 0.08 13.2 0.0 1.1 1 0 0 1 1 1 0 Actinobacteria/chloroflexi VLRF1 release factor APH PF01636.23 CDF38895.1 - 2.1e-09 37.6 0.2 4.5e-09 36.6 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF38895.1 - 0.023 14.3 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 CDF38896.1 - 5.8e-09 36.2 0.4 1.4e-08 35.0 0.4 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF38896.1 - 0.022 14.1 0.0 0.1 11.9 0.0 1.8 1 1 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 CDF38896.1 - 0.2 11.2 0.0 0.38 10.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 CDF38898.1 - 2.9e-09 37.2 0.2 5.2e-09 36.4 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF38898.1 - 0.019 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 CDF38900.1 - 6.1e-09 36.2 0.2 1.1e-08 35.3 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YojJ PF10372.9 CDF38900.1 - 0.02 14.9 0.4 3.8 7.7 0.0 2.8 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus EcKinase PF02958.20 CDF38900.1 - 0.11 11.8 0.0 0.36 10.1 0.0 1.8 1 1 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 CDF38900.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase CN_hydrolase PF00795.22 CDF38901.1 - 0.074 12.4 0.0 0.089 12.1 0.0 1.1 1 0 0 1 1 1 0 Carbon-nitrogen hydrolase WD40 PF00400.32 CDF38902.1 - 1.4e-13 51.0 3.0 9e-10 39.0 0.3 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38902.1 - 0.006 16.9 0.0 0.016 15.5 0.0 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF38902.1 - 0.11 11.1 1.0 2.8 6.5 0.2 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Sulfotransfer_1 PF00685.27 CDF38906.1 - 1.1e-24 87.4 0.0 1.8e-24 86.6 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDF38906.1 - 0.12 12.7 0.0 15 5.9 0.0 2.5 2 0 0 2 2 2 0 Sulfotransferase family DDE_3 PF13358.6 CDF38907.1 - 3.8e-19 68.9 0.0 6.6e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF38907.1 - 5e-09 35.9 0.0 1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_32 PF13565.6 CDF38907.1 - 1.6e-05 25.4 1.3 0.051 14.2 0.1 2.6 1 1 1 2 2 2 2 Homeodomain-like domain HTH_38 PF13936.6 CDF38907.1 - 3.7e-05 23.4 0.2 8.7e-05 22.2 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain DUF1295 PF06966.12 CDF38909.1 - 2.1e-09 37.3 0.2 2.8e-09 36.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Pyridoxal_deC PF00282.19 CDF38911.1 - 2.6e-19 69.2 0.0 2.6e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CDF38911.1 - 0.0071 15.7 0.0 0.034 13.4 0.0 2.0 3 0 0 3 3 3 1 Beta-eliminating lyase Maf PF02545.14 CDF38915.1 - 2.5e-59 199.9 0.0 2.8e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein S1 PF00575.23 CDF38916.1 - 4.7e-24 84.5 20.7 2.1e-07 31.2 0.1 8.3 10 0 0 10 10 9 4 S1 RNA binding domain Suf PF05843.14 CDF38916.1 - 6.5e-07 29.6 10.8 0.18 11.8 0.1 4.3 4 1 0 4 4 4 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CDF38916.1 - 6.8e-05 23.4 5.4 1.4 9.9 0.0 5.3 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF38916.1 - 0.00047 20.6 0.1 0.29 11.7 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CDF38916.1 - 0.00075 18.7 6.6 0.074 12.2 0.3 2.9 2 0 0 2 2 2 2 NRDE-2, necessary for RNA interference TPR_15 PF13429.6 CDF38916.1 - 0.0014 17.9 5.4 0.0019 17.5 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDF38916.1 - 0.025 14.7 1.8 0.12 12.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat HCV_env PF01539.17 CDF38916.1 - 0.026 14.2 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 TPR_8 PF13181.6 CDF38916.1 - 0.064 13.5 0.4 0.43 10.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF38916.1 - 0.075 13.1 0.0 4.9 7.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF38916.1 - 0.25 11.7 5.9 1.4 9.2 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF38916.1 - 0.65 10.7 8.9 0.23 12.1 0.4 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF38916.1 - 0.65 10.8 2.6 70 4.4 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.32 CDF38917.1 - 2.5e-18 66.1 8.1 2.8e-05 24.8 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38917.1 - 7.7e-10 38.9 0.0 0.026 14.8 0.0 4.9 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF38917.1 - 3.1e-05 23.1 0.1 0.19 10.6 0.0 3.1 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Prenylcys_lyase PF07156.14 CDF38918.1 - 5e-66 223.3 0.0 6.8e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 CDF38918.1 - 2.5e-11 43.6 0.0 4.8e-10 39.3 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF38918.1 - 1.8e-09 37.7 0.0 4.2e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 CDF38918.1 - 0.0056 15.3 0.0 0.0099 14.5 0.0 1.4 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 CDF38918.1 - 0.0096 15.5 0.0 0.028 14.0 0.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDF38918.1 - 0.014 15.4 0.4 4.2 7.3 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CDF38918.1 - 0.054 12.7 0.2 6.5 5.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Got1 PF04178.12 CDF38919.1 - 1.5e-28 99.4 14.0 1.5e-28 99.4 14.0 1.5 1 1 1 2 2 2 2 Got1/Sft2-like family DUF2048 PF09752.9 CDF38920.1 - 2.1e-42 145.5 0.0 5.2e-40 137.6 0.0 2.2 1 1 1 2 2 2 2 Abhydrolase domain containing 18 Abhydrolase_1 PF00561.20 CDF38920.1 - 0.15 11.7 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 CDF38920.1 - 0.22 11.1 0.1 0.29 10.7 0.1 1.1 1 0 0 1 1 1 0 Putative esterase Ion_trans PF00520.31 CDF38922.1 - 9.1e-22 77.5 6.7 1.5e-21 76.7 6.7 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 CDF38922.1 - 2.6e-13 49.7 7.3 2.6e-13 49.7 7.3 1.9 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.29 CDF38922.1 - 1.5e-10 41.0 0.0 2.7e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain IRK PF01007.20 CDF38922.1 - 0.00024 20.9 1.1 0.00059 19.7 0.5 2.0 2 0 0 2 2 2 1 Inward rectifier potassium channel transmembrane domain PRD1_DD PF11087.8 CDF38922.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 PRD1 phage membrane DNA delivery SNF2_N PF00176.23 CDF38923.1 - 4.7e-23 81.5 0.0 9.3e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-GRF PF06839.12 CDF38923.1 - 5.4e-15 55.2 14.4 1.4e-12 47.5 6.9 2.8 3 0 0 3 3 3 2 GRF zinc finger Helicase_C PF00271.31 CDF38923.1 - 1.5e-13 51.0 0.0 6.2e-13 49.1 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDF38923.1 - 0.0073 15.5 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CDF38923.1 - 0.032 14.3 0.0 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Glyco_transf_7C PF02709.14 CDF38926.1 - 4.6e-10 39.0 0.2 4.6e-10 39.0 0.2 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Rab_eff_C PF04698.12 CDF38926.1 - 0.00085 17.7 0.0 0.0012 17.2 0.0 1.1 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus Glyco_tranf_2_2 PF10111.9 CDF38926.1 - 0.059 12.8 0.1 0.11 11.9 0.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 LRR_8 PF13855.6 CDF38927.1 - 1.4e-35 120.9 30.4 1.1e-10 41.1 0.5 3.9 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 CDF38927.1 - 1.4e-18 66.6 16.2 3e-06 27.5 0.3 6.2 3 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDF38927.1 - 5e-10 38.6 10.0 0.33 11.1 0.0 7.1 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 CDF38927.1 - 1e-09 37.6 3.4 1 10.1 0.0 7.0 8 1 0 8 8 8 3 Leucine Rich Repeat ERG2_Sigma1R PF04622.12 CDF38928.1 - 1.1e-78 263.4 0.0 1.3e-78 263.2 0.0 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Thioredoxin PF00085.20 CDF38929.1 - 2.2e-24 85.4 0.1 5e-24 84.3 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin HipN PF18253.1 CDF38929.1 - 5e-13 48.5 0.0 9.1e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain TPR_1 PF00515.28 CDF38929.1 - 3.4e-09 36.1 0.0 0.00073 19.3 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF38929.1 - 1.9e-08 33.8 0.2 0.038 14.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Thioredoxin_2 PF13098.6 CDF38929.1 - 3.7e-07 30.6 0.4 8.9e-07 29.3 0.0 1.9 2 0 0 2 2 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDF38929.1 - 5.7e-07 29.3 0.5 1.2e-06 28.3 0.0 1.7 2 0 0 2 2 1 1 Thioredoxin TPR_9 PF13371.6 CDF38929.1 - 8.2e-05 22.7 0.2 0.0013 18.9 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat Thioredoxin_8 PF13905.6 CDF38929.1 - 0.00056 20.2 0.1 0.051 13.9 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like TPR_8 PF13181.6 CDF38929.1 - 0.00056 19.9 0.1 0.1 12.9 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat STI1 PF17830.1 CDF38929.1 - 0.00058 19.7 0.3 0.0029 17.5 0.2 2.2 1 1 1 2 2 2 1 STI1 domain TPR_12 PF13424.6 CDF38929.1 - 0.00083 19.6 0.1 0.0049 17.1 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF38929.1 - 0.0013 19.4 5.6 0.042 14.7 0.1 4.0 2 1 2 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDF38929.1 - 0.002 17.7 0.1 0.82 9.4 0.0 2.9 1 1 2 3 3 3 1 TPR repeat TPR_16 PF13432.6 CDF38929.1 - 0.0025 18.4 0.2 0.0025 18.4 0.2 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat Thioredoxin_7 PF13899.6 CDF38929.1 - 0.0044 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CDF38929.1 - 0.0051 16.7 0.0 0.018 15.0 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family TPR_17 PF13431.6 CDF38929.1 - 0.03 14.7 0.0 0.13 12.7 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF38929.1 - 0.066 13.9 0.1 18 6.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF38929.1 - 0.067 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 OST3_OST6 PF04756.13 CDF38929.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF2039 PF10217.9 CDF38932.1 - 1.8e-26 92.3 8.0 2.2e-26 92.0 8.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zf-C3HC4_3 PF13920.6 CDF38932.1 - 0.0052 16.6 10.0 0.24 11.3 6.8 2.6 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Cript PF10235.9 CDF38932.1 - 0.12 13.0 12.4 0.36 11.4 8.1 2.1 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT Tnp_zf-ribbon_2 PF13842.6 CDF38932.1 - 0.24 12.2 10.0 0.36 11.7 6.1 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zinc-ribbons_6 PF07191.12 CDF38932.1 - 0.69 9.9 9.5 1.5 8.9 9.5 1.5 1 1 0 1 1 1 0 zinc-ribbons ketoacyl-synt PF00109.26 CDF38933.1 - 2.2e-22 79.9 1.0 6.2e-22 78.4 1.0 1.6 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Tmemb_18A PF09771.9 CDF38935.1 - 0.1 13.0 0.1 0.47 10.9 0.0 1.8 1 1 1 2 2 2 0 Transmembrane protein 188 DDE_Tnp_4 PF13359.6 CDF38936.1 - 2.2e-19 69.7 0.0 2.5e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CDF38936.1 - 1.1e-05 25.2 0.1 3.3e-05 23.6 0.1 1.7 1 1 0 1 1 1 1 Transposase DDE domain RNase_T PF00929.24 CDF38937.1 - 1.2e-05 26.0 0.0 3.5e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Exonuclease zf-C3HC PF07967.13 CDF38939.1 - 2.1e-08 34.3 0.0 3.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 C3HC zinc finger-like HTH_Tnp_Tc3_1 PF11427.8 CDF38941.1 - 2.7e-08 33.5 0.0 6.3e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF38941.1 - 3.9e-05 23.3 3.3 4e-05 23.3 0.8 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF38941.1 - 0.00053 20.5 2.0 0.031 14.9 0.2 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF38941.1 - 0.039 14.2 0.5 0.14 12.4 0.1 2.1 1 1 1 2 2 2 0 Transposase DDE_3 PF13358.6 CDF38942.1 - 2.8e-10 40.1 1.0 9.9e-10 38.3 0.1 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease SBP_bac_3 PF00497.20 CDF38943.1 - 3.2e-11 43.1 0.0 2e-10 40.5 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CDF38943.1 - 0.00013 22.1 0.0 0.0004 20.6 0.0 1.8 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 CDF38943.1 - 0.04 13.8 0.0 0.083 12.7 0.0 1.6 1 1 0 1 1 1 0 Ligand-gated ion channel FAM180 PF15173.6 CDF38943.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 FAM180 family Aminotran_1_2 PF00155.21 CDF38944.1 - 4e-65 220.3 0.0 5e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4571 PF15137.6 CDF38944.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) Piwi PF02171.17 CDF38945.1 - 5e-78 262.4 0.0 8.5e-78 261.6 0.0 1.4 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CDF38945.1 - 5.5e-12 46.5 0.8 1.1e-11 45.5 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of argonaute PAZ PF02170.22 CDF38945.1 - 2.6e-07 30.5 0.1 6.3e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CDF38945.1 - 1.1e-06 28.2 0.0 3.2e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoMid PF16487.5 CDF38945.1 - 3.8e-06 27.1 0.0 1.3e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 CDF38945.1 - 7.2e-05 23.0 0.2 0.00027 21.2 0.1 2.1 2 0 0 2 2 2 1 Argonaute linker 2 domain YchF-GTPase_C PF06071.13 CDF38946.1 - 0.14 12.4 0.0 3 8.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF933) tRNA-synt_2 PF00152.20 CDF38947.1 - 6.7e-74 248.8 0.0 9.2e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDF38947.1 - 3e-07 30.3 0.9 5.5e-07 29.5 0.9 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDF38947.1 - 0.00066 19.2 0.1 0.06 12.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) APH PF01636.23 CDF38954.1 - 0.00011 22.2 1.1 0.00011 22.2 1.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF2039 PF10217.9 CDF38955.1 - 0.21 11.9 0.2 0.21 11.9 0.2 2.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2039) Ephrin_rec_like PF07699.13 CDF38957.1 - 0.012 15.3 1.0 0.015 15.0 0.3 1.5 1 1 0 1 1 1 0 Putative ephrin-receptor like WD40 PF00400.32 CDF38958.1 - 2.1e-05 25.1 0.1 0.39 11.7 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 CDF38958.1 - 0.013 14.1 0.3 2.2 6.8 0.1 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 NMT_C PF02799.15 CDF38959.1 - 1.4e-54 184.8 0.3 1.6e-54 184.6 0.3 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain KNOX1 PF03790.13 CDF38959.1 - 0.11 12.2 0.4 0.22 11.3 0.4 1.4 1 0 0 1 1 1 0 KNOX1 domain Glycos_transf_1 PF00534.20 CDF38961.1 - 2.4e-22 79.3 0.0 3.9e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF38961.1 - 1.3e-21 77.4 0.1 2.3e-21 76.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_2 PF00535.26 CDF38961.1 - 2.5e-08 33.9 0.1 8.6e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_trans_1_2 PF13524.6 CDF38961.1 - 0.00035 20.9 0.0 0.00091 19.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Gemini_AL1_M PF08283.11 CDF38961.1 - 0.076 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Geminivirus rep protein central domain DUF826 PF05696.11 CDF38961.1 - 0.14 12.3 0.0 0.49 10.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF826) WD40 PF00400.32 CDF38963.1 - 3.1e-71 233.5 41.9 1.3e-09 38.5 0.2 10.5 10 0 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38963.1 - 6.4e-19 68.1 15.2 0.002 18.4 0.0 9.5 2 1 8 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF38963.1 - 5.8e-13 48.6 0.0 1.2e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Nup160 PF11715.8 CDF38963.1 - 2e-07 30.1 10.9 7.1 5.1 0.0 9.1 7 2 0 10 10 10 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF38963.1 - 3.1e-06 26.4 1.2 8.4 5.2 0.0 6.4 1 1 4 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF38963.1 - 0.0025 18.3 30.0 4.2 8.0 0.3 9.0 3 3 6 9 9 9 3 PQQ-like domain AAA_22 PF13401.6 CDF38963.1 - 0.0029 17.9 0.0 0.0095 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain PQQ PF01011.21 CDF38963.1 - 0.0033 17.3 0.0 57 3.9 0.0 5.9 8 0 0 8 8 8 0 PQQ enzyme repeat PQQ_2 PF13360.6 CDF38963.1 - 0.06 12.9 41.6 0.2 11.2 10.1 3.9 1 1 2 3 3 3 0 PQQ-like domain Frtz PF11768.8 CDF38963.1 - 0.066 11.5 0.0 16 3.7 0.0 4.3 2 2 4 6 6 6 0 WD repeat-containing and planar cell polarity effector protein Fritz rve PF00665.26 CDF38965.1 - 4.9e-09 36.4 0.1 5.6e-09 36.2 0.1 1.0 1 0 0 1 1 1 1 Integrase core domain BBE PF08031.12 CDF38968.1 - 3.2e-14 52.7 0.0 3.8e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Berberine and berberine like ALO PF04030.14 CDF38968.1 - 0.059 13.2 0.0 0.059 13.2 0.0 1.1 1 0 0 1 1 1 0 D-arabinono-1,4-lactone oxidase Y_Y_Y PF07495.13 CDF38970.1 - 0.026 14.4 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Y_Y_Y domain PPC PF04151.15 CDF38970.1 - 0.096 13.8 0.0 0.19 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain DUF2141 PF09912.9 CDF38970.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2141) Y_Y_Y PF07495.13 CDF38971.1 - 0.026 14.4 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Y_Y_Y domain PPC PF04151.15 CDF38971.1 - 0.096 13.8 0.0 0.19 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain DUF2141 PF09912.9 CDF38971.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2141) DDE_3 PF13358.6 CDF38973.1 - 1.3e-08 34.8 0.0 1.6e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.32 CDF38974.1 - 8.5e-80 260.6 81.3 4.5e-07 30.5 0.9 18.1 18 0 0 18 18 18 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38974.1 - 1.5e-19 70.1 31.1 0.0048 17.2 0.0 13.5 3 2 10 15 15 15 8 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF38974.1 - 1.9e-13 50.2 0.0 3.1e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain WD40_like PF17005.5 CDF38974.1 - 1.4e-05 24.6 0.0 1.2 8.4 0.0 4.8 4 1 2 6 6 6 3 WD40-like domain Ge1_WD40 PF16529.5 CDF38974.1 - 0.0017 17.4 11.1 3.6 6.5 0.0 7.7 4 3 5 10 10 10 1 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 CDF38974.1 - 0.052 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF5018 PF16410.5 CDF38974.1 - 0.15 10.7 2.7 0.35 9.5 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5018) Ephrin_rec_like PF07699.13 CDF38975.1 - 9.4e-113 367.8 209.8 5.5e-12 45.3 7.5 19.1 4 3 16 22 22 22 20 Putative ephrin-receptor like NCD3G PF07562.14 CDF38975.1 - 2.1e-36 123.7 156.1 0.0012 18.7 2.4 19.9 3 1 10 22 22 22 22 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDF38975.1 - 2e-19 69.7 155.6 0.13 12.7 1.1 24.1 7 4 16 25 25 25 20 TNFR/NGFR cysteine-rich region VSP PF03302.13 CDF38975.1 - 0.97 8.2 156.1 0.62 8.8 21.8 8.7 1 1 8 9 9 9 0 Giardia variant-specific surface protein Ephrin_rec_like PF07699.13 CDF38976.1 - 1.4e-40 136.8 114.6 6.7e-09 35.4 4.1 9.2 1 1 9 10 10 10 10 Putative ephrin-receptor like NCD3G PF07562.14 CDF38976.1 - 3.2e-16 59.0 60.4 1.4e-05 24.9 3.0 8.2 2 2 5 9 9 9 9 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDF38976.1 - 7.5e-10 39.0 64.4 0.13 12.7 0.2 11.1 2 2 9 12 12 12 11 TNFR/NGFR cysteine-rich region VSP PF03302.13 CDF38976.1 - 0.079 11.8 58.8 1.1 8.0 5.6 3.8 1 1 4 5 5 5 0 Giardia variant-specific surface protein DNA_ligase_OB_2 PF14743.6 CDF38976.1 - 0.19 11.8 0.9 7.7 6.6 0.1 3.2 4 0 0 4 4 4 0 DNA ligase OB-like domain WD40 PF00400.32 CDF38978.1 - 2e-57 189.8 36.7 8.2e-08 32.8 0.1 8.6 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF38978.1 - 2.7e-17 62.8 13.6 0.061 13.6 0.0 7.8 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF38978.1 - 1.2e-13 50.9 0.0 2.2e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Ge1_WD40 PF16529.5 CDF38978.1 - 1.2e-05 24.5 0.4 6 5.7 0.0 5.5 1 1 6 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDF38978.1 - 7.7e-05 21.5 7.7 15 4.1 0.0 7.3 7 1 1 8 8 8 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CDF38978.1 - 0.00012 22.4 31.3 0.91 10.1 0.6 8.1 3 2 6 9 9 8 5 PQQ-like domain PQQ PF01011.21 CDF38978.1 - 0.00052 19.8 0.0 19 5.4 0.0 6.0 7 0 0 7 7 7 0 PQQ enzyme repeat AAA_22 PF13401.6 CDF38978.1 - 0.0021 18.3 0.0 0.0062 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF3952 PF13130.6 CDF38978.1 - 0.0063 16.7 2.1 3.8 7.7 0.0 4.5 3 1 1 4 4 4 1 Domain of unknown function (DUF3952) Nucleoporin_N PF08801.11 CDF38978.1 - 0.025 13.3 0.5 13 4.4 0.0 3.9 1 1 2 4 4 4 0 Nup133 N terminal like XS PF03468.14 CDF38978.1 - 0.08 13.2 0.1 4.1 7.7 0.0 2.4 2 0 0 2 2 2 0 XS domain PQQ_2 PF13360.6 CDF38978.1 - 0.084 12.4 37.8 0.11 12.1 17.3 3.8 2 1 2 4 4 4 0 PQQ-like domain Peptidase_S9_N PF02897.15 CDF38978.1 - 1.1 8.0 4.9 16 4.2 0.1 4.0 1 1 4 5 5 5 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Sel1 PF08238.12 CDF38985.1 - 8e-05 23.2 2.8 0.59 10.9 0.1 4.4 4 0 0 4 4 4 1 Sel1 repeat PBP1_TM PF14812.6 CDF38985.1 - 0.0037 17.6 0.6 0.009 16.4 0.6 1.7 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Drf_FH3 PF06367.16 CDF38985.1 - 0.028 14.0 0.3 0.042 13.5 0.3 1.2 1 0 0 1 1 1 0 Diaphanous FH3 Domain FAM176 PF14851.6 CDF38985.1 - 0.029 14.0 1.7 0.061 13.0 1.7 1.5 1 0 0 1 1 1 0 FAM176 family Paf1 PF03985.13 CDF38985.1 - 0.17 10.9 2.1 0.21 10.5 2.1 1.1 1 0 0 1 1 1 0 Paf1 Pes-10 PF07149.11 CDF38985.1 - 0.41 9.7 4.5 0.56 9.2 4.5 1.2 1 0 0 1 1 1 0 Pes-10 DNA_pol_phi PF04931.13 CDF38985.1 - 0.56 8.2 3.8 0.63 8.1 3.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi TPR_14 PF13428.6 CDF38985.1 - 1 10.4 10.9 5 8.2 0.2 4.7 3 2 2 5 5 5 0 Tetratricopeptide repeat Plant_tran PF04827.14 CDF38988.1 - 3.4e-29 101.9 0.0 4.7e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF38988.1 - 0.087 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease PsbQ PF05757.11 CDF38995.1 - 0.004 16.9 0.2 0.0053 16.5 0.2 1.1 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) 7TMR-HDED PF07697.11 CDF38995.1 - 0.049 13.7 1.0 0.11 12.7 1.0 1.5 1 1 0 1 1 1 0 7TM-HD extracellular adh_short PF00106.25 CDF38996.1 - 1.2e-27 96.6 0.0 4.1e-22 78.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDF38996.1 - 1.4e-16 60.7 0.0 5e-13 49.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDF38996.1 - 4.2e-05 23.1 0.0 5.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CDF38996.1 - 0.001 19.0 0.0 0.003 17.5 0.0 1.7 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 CDF38996.1 - 0.092 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain GAF PF01590.26 CDF38997.1 - 2.5e-05 24.9 0.0 6.2e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 CDF38997.1 - 0.00015 22.1 0.0 0.00029 21.2 0.0 1.4 1 0 0 1 1 1 1 GAF domain bHLH-MYC_N PF14215.6 CDF38997.1 - 0.00035 20.9 0.0 0.00097 19.5 0.0 1.7 1 1 0 1 1 1 1 bHLH-MYC and R2R3-MYB transcription factors N-terminal HLH PF00010.26 CDF38997.1 - 0.02 14.8 0.0 0.064 13.2 0.0 1.8 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain GldH_lipo PF14109.6 CDF38997.1 - 0.065 14.0 0.0 0.14 12.9 0.0 1.5 1 0 0 1 1 1 0 GldH lipoprotein Porin_3 PF01459.22 CDF38998.1 - 1.2e-29 103.6 4.4 1.8e-29 103.0 4.4 1.3 1 0 0 1 1 1 1 Eukaryotic porin Fer2 PF00111.27 CDF38999.1 - 1.4e-08 34.5 0.2 2.3e-08 33.8 0.2 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_4 PF13510.6 CDF38999.1 - 0.054 13.5 0.1 0.12 12.4 0.1 1.7 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF1298 PF06974.13 CDF39000.1 - 5.4e-25 88.1 0.0 9.1e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 CDF39000.1 - 7.1e-12 45.7 0.0 1.5e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain MutL_C PF08676.11 CDF39001.1 - 2.1e-28 99.0 0.1 4.5e-28 97.9 0.1 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CDF39001.1 - 9.1e-14 51.2 0.0 2.3e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CDF39001.1 - 1.6e-11 44.2 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDF39001.1 - 4.6e-05 23.9 0.0 0.00011 22.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DHquinase_II PF01220.19 CDF39001.1 - 0.062 13.0 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Dehydroquinase class II DUF1298 PF06974.13 CDF39002.1 - 2.5e-30 105.3 0.0 4.3e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 CDF39002.1 - 1.8e-09 37.8 0.6 9.2e-09 35.4 0.6 2.1 1 1 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 CDF39002.1 - 0.1 11.2 0.7 0.6 8.7 0.0 2.0 2 0 0 2 2 2 0 Condensation domain Squash PF00299.18 CDF39003.1 - 9.2 6.4 10.7 2.7 8.1 2.1 2.6 2 0 0 2 2 2 0 Squash family serine protease inhibitor Rad51 PF08423.11 CDF39004.1 - 3.6e-30 105.1 0.0 4.7e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 CDF39004.1 - 6.7e-06 25.6 0.0 3.4e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 CDF39004.1 - 6.1e-05 22.7 0.6 0.00011 21.8 0.6 1.4 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 CDF39004.1 - 0.00029 20.4 0.2 0.00053 19.5 0.2 1.3 1 1 0 1 1 1 1 recA bacterial DNA recombination protein PAXNEB PF05625.11 CDF39004.1 - 0.0074 15.5 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 PAXNEB protein AAA_30 PF13604.6 CDF39004.1 - 0.042 13.6 0.8 0.13 12.0 0.7 1.8 1 1 0 1 1 1 0 AAA domain HEAT_2 PF13646.6 CDF39006.1 - 1.1e-08 35.3 10.5 0.21 12.0 0.0 6.9 7 0 0 7 7 7 4 HEAT repeats CLASP_N PF12348.8 CDF39006.1 - 2.3e-07 30.6 0.0 0.0012 18.4 0.1 3.4 3 0 0 3 3 3 2 CLASP N terminal HEAT_EZ PF13513.6 CDF39006.1 - 0.0075 16.8 1.7 2.3 8.8 0.0 5.4 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 CDF39006.1 - 0.022 15.0 20.7 0.22 11.9 0.0 7.9 10 0 0 10 10 10 0 HEAT repeat Glucokinase PF02685.16 CDF39006.1 - 0.092 11.7 0.1 0.17 10.8 0.1 1.4 1 0 0 1 1 1 0 Glucokinase Enolase_N PF03952.16 CDF39006.1 - 0.094 12.9 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Enolase, N-terminal domain TCRP1 PF14944.6 CDF39006.1 - 0.18 11.7 2.3 0.4 10.6 2.3 1.5 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 Peptidase_M50 PF02163.22 CDF39008.1 - 3.1e-57 193.7 0.0 3.8e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.6 CDF39008.1 - 3.2e-07 30.6 0.0 8.1e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDF39008.1 - 1.5e-05 24.8 0.2 3.8e-05 23.4 0.2 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDF39008.1 - 0.002 18.4 0.1 0.0043 17.4 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Peptidase_M50B PF13398.6 CDF39008.1 - 0.0071 16.0 0.5 0.0071 16.0 0.5 2.2 2 1 0 2 2 2 1 Peptidase M50B-like Tricorn_PDZ PF14685.6 CDF39008.1 - 0.1 12.6 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Dickkopf_N PF04706.12 CDF39009.1 - 1.5 9.3 14.1 11 6.6 14.1 2.1 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region HSP9_HSP12 PF04119.12 CDF39011.1 - 1.5 9.3 7.8 0.81 10.1 0.6 3.0 1 1 2 3 3 3 0 Heat shock protein 9/12 DUF2867 PF11066.8 CDF39012.1 - 0.05 13.9 0.9 0.083 13.2 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) DUF3395 PF11875.8 CDF39014.1 - 6.5e-29 100.8 0.0 1.1e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 CDF39014.1 - 2e-18 66.3 2.0 3.6e-18 65.5 2.0 1.4 1 0 0 1 1 1 1 DnaJ domain UDPG_MGDP_dh_C PF03720.15 CDF39014.1 - 0.016 15.6 0.2 0.051 14.0 0.2 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Anp1 PF03452.14 CDF39014.1 - 0.025 14.0 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 Anp1 zf-H2C2_2 PF13465.6 CDF39015.1 - 1.1e-07 32.0 4.7 1.5e-06 28.3 1.2 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 CDF39015.1 - 9.2e-07 29.0 4.4 0.00034 20.9 0.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF39015.1 - 0.026 15.3 5.0 0.7 10.9 0.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CDF39015.1 - 0.049 13.9 0.3 0.46 10.8 0.3 2.2 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 CDF39015.1 - 0.15 12.2 1.5 7 6.8 0.2 2.1 1 1 1 2 2 2 0 Aberrant zinc-finger CinA_KH PF18146.1 CDF39015.1 - 0.19 11.9 1.8 0.33 11.1 1.8 1.4 1 0 0 1 1 1 0 Damage-inducible protein CinA KH domain BAF1_ABF1 PF04684.13 CDF39015.1 - 2.7 6.9 7.5 6.4 5.7 4.7 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor zf-rbx1 PF12678.7 CDF39016.1 - 3.3e-25 88.1 13.1 4.5e-25 87.7 13.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDF39016.1 - 9.5e-19 67.3 8.7 1.2e-18 66.9 8.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CDF39016.1 - 5.8e-06 26.6 15.1 0.00015 22.0 15.1 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDF39016.1 - 4.8e-05 23.1 2.5 4.8e-05 23.1 2.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF39016.1 - 0.00092 19.0 11.6 0.01 15.7 11.6 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) VSP PF03302.13 CDF39016.1 - 0.0059 15.5 1.5 0.0066 15.4 1.5 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein FANCL_C PF11793.8 CDF39016.1 - 0.11 12.7 8.3 0.31 11.3 8.4 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 CDF39016.1 - 0.2 11.7 7.7 0.54 10.3 7.7 1.8 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDF39016.1 - 0.38 10.6 10.7 1.1 9.2 4.4 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDF39016.1 - 0.47 10.1 14.7 0.086 12.5 4.9 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 CDF39016.1 - 2.5 7.9 18.0 76 3.2 18.0 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 CDF39016.1 - 6.3 6.9 11.3 37 4.4 11.3 2.3 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING-like PF08746.11 CDF39016.1 - 8.2 6.8 12.2 62 4.0 12.2 2.2 1 1 0 1 1 1 0 RING-like domain DNA_ligase_A_M PF01068.21 CDF39017.1 - 2.3e-60 203.8 0.0 3.6e-60 203.1 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CDF39017.1 - 3.7e-44 151.1 0.1 9.1e-44 149.8 0.1 1.7 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CDF39017.1 - 5.8e-25 87.8 0.0 1.7e-24 86.2 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.6 CDF39017.1 - 0.081 13.0 0.1 7 6.8 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain Abhydrolase_6 PF12697.7 CDF39018.1 - 1.7e-05 25.5 0.1 2.1e-05 25.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 CDF39018.1 - 0.014 14.9 0.2 0.042 13.4 0.2 1.6 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Nop52 PF05997.12 CDF39019.1 - 3.5e-37 128.3 0.1 4.5e-37 128.0 0.1 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 CDF39019.1 - 0.066 13.3 0.2 0.46 10.6 0.0 2.3 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair HEAT PF02985.22 CDF39019.1 - 0.12 12.7 0.0 0.43 11.0 0.0 1.9 1 0 0 1 1 1 0 HEAT repeat CDT1 PF08839.11 CDF39020.1 - 1.8e-20 73.9 0.0 6.1e-18 65.7 0.0 2.4 2 0 0 2 2 2 2 DNA replication factor CDT1 like CDT1_C PF16679.5 CDF39020.1 - 3.4e-10 40.2 2.5 9.4e-10 38.8 0.7 2.5 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain STT3 PF02516.14 CDF39022.1 - 3.9e-114 382.3 26.0 6.8e-114 381.5 26.0 1.3 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 CDF39022.1 - 0.054 13.7 21.3 0.024 14.9 14.6 2.9 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase zf-C2H2 PF00096.26 CDF39023.1 - 1.3e-17 63.1 32.5 0.00081 19.7 2.5 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF39023.1 - 5e-13 48.7 32.8 0.019 15.8 2.7 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF39023.1 - 5.3e-10 39.3 27.1 0.001 19.4 0.4 5.9 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_11 PF16622.5 CDF39023.1 - 2.4e-09 36.8 17.3 0.071 12.9 0.1 4.8 4 0 0 4 4 4 4 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 CDF39023.1 - 1.2e-07 32.5 25.1 0.033 14.9 8.1 4.1 1 1 2 3 3 3 3 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 CDF39023.1 - 0.059 13.8 15.3 14 6.2 0.0 5.2 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-AN1 PF01428.16 CDF39023.1 - 0.095 12.9 13.1 22 5.3 0.1 5.4 5 0 0 5 5 5 0 AN1-like Zinc finger Prok-RING_1 PF14446.6 CDF39023.1 - 0.21 11.5 8.6 21 5.2 0.1 4.6 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 zf-Di19 PF05605.12 CDF39023.1 - 0.22 11.9 20.5 0.53 10.6 4.7 3.6 2 2 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 CDF39023.1 - 0.56 10.5 8.7 10 6.5 8.6 2.8 1 1 0 1 1 1 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 CDF39023.1 - 0.72 10.6 15.6 30 5.5 4.0 3.3 1 1 2 3 3 3 0 zinc-ribbon family WAC_Acf1_DNA_bd PF10537.9 CDF39023.1 - 0.81 10.2 3.6 2 9.0 0.9 2.3 1 1 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal ADK_lid PF05191.14 CDF39023.1 - 3.3 7.8 10.6 35 4.5 0.4 3.8 3 0 0 3 3 3 0 Adenylate kinase, active site lid Elf1 PF05129.13 CDF39023.1 - 3.5 7.7 22.6 0.82 9.8 2.2 3.8 1 1 3 4 4 4 0 Transcription elongation factor Elf1 like zf-H2C2_5 PF13909.6 CDF39023.1 - 3.6 7.4 13.3 12 5.8 1.5 4.4 4 0 0 4 4 4 0 C2H2-type zinc-finger domain YhfH PF14149.6 CDF39023.1 - 5.3 7.1 7.7 9 6.4 0.4 3.5 3 0 0 3 3 3 0 YhfH-like protein BolA PF01722.18 CDF39023.1 - 7.2 7.0 7.1 19 5.6 0.2 2.9 1 1 0 2 2 2 0 BolA-like protein HypA PF01155.19 CDF39023.1 - 7.8 6.6 16.0 10 6.2 1.7 3.3 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_4 PF07975.12 CDF39023.1 - 9.8 6.5 18.6 4.1 7.7 4.3 3.4 2 1 0 2 2 2 0 TFIIH C1-like domain DUF688 PF05097.12 CDF39024.1 - 0.11 11.7 0.9 0.13 11.4 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF688) Cwf_Cwc_15 PF04889.12 CDF39024.1 - 3.7 7.2 9.2 5.8 6.6 9.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 CDF39024.1 - 3.9 7.9 17.4 1.2 9.6 5.0 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain TFIIE-A_C PF11521.8 CDF39024.1 - 9.9 6.5 11.3 0.83 10.0 4.1 2.1 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Bromodomain PF00439.25 CDF39025.1 - 1.6e-18 66.5 0.0 3.2e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Bromodomain BET PF17035.5 CDF39025.1 - 3.2e-11 43.2 2.5 8.1e-11 41.9 2.5 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF2026 PF09641.10 CDF39025.1 - 0.0048 16.6 1.0 0.62 9.7 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2026) DUF5137 PF17220.3 CDF39025.1 - 0.14 13.1 3.4 17 6.3 1.4 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF5137) TerB PF05099.13 CDF39025.1 - 0.57 10.1 4.1 3.9 7.4 0.2 2.5 2 0 0 2 2 2 0 Tellurite resistance protein TerB SRP-alpha_N PF04086.13 CDF39025.1 - 0.66 9.9 26.1 0.12 12.3 12.5 2.3 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Cdh1_DBD_1 PF18196.1 CDF39025.1 - 0.7 10.2 6.9 0.25 11.7 1.9 2.6 2 1 1 3 3 3 0 Chromodomain helicase DNA-binding domain 1 FKBP_N PF01346.18 CDF39025.1 - 1 10.4 6.7 0.45 11.5 2.9 2.4 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase HATPase_c PF02518.26 CDF39026.1 - 1.3e-11 45.0 0.0 1.8e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDF39026.1 - 0.0026 17.8 0.1 0.0049 16.9 0.1 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CDF39026.1 - 0.22 11.4 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase V-ATPase_H_C PF11698.8 CDF39027.1 - 5.3e-27 94.3 0.1 1e-26 93.4 0.1 1.4 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 CDF39027.1 - 0.045 13.0 0.3 0.22 10.8 0.0 2.0 1 1 1 2 2 2 0 V-ATPase subunit H HEAT PF02985.22 CDF39027.1 - 0.047 14.0 0.1 0.47 10.8 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat DRMBL PF07522.14 CDF39029.1 - 2.2e-07 31.0 0.0 0.0012 19.0 0.0 2.4 1 1 1 2 2 2 2 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 CDF39029.1 - 0.0007 19.7 0.1 0.0016 18.5 0.1 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF39029.1 - 0.052 13.1 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain ATP-synt_ab PF00006.25 CDF39033.1 - 2.2e-72 243.2 0.0 4e-72 242.3 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CDF39033.1 - 2.4e-47 160.4 0.3 4.1e-47 159.6 0.3 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CDF39033.1 - 2.6e-17 63.1 0.9 8.8e-17 61.4 0.9 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.6 CDF39033.1 - 0.0029 17.9 0.9 0.0074 16.5 0.9 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4142) HAS-barrel PF09378.10 CDF39033.1 - 0.0083 16.3 0.1 0.021 15.0 0.1 1.8 1 0 0 1 1 1 1 HAS barrel domain CAP_GLY PF01302.25 CDF39034.1 - 6.8e-15 54.8 0.1 1.3e-14 54.0 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 CDF39034.1 - 8e-14 51.5 0.8 0.0066 16.8 0.0 4.9 5 1 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDF39034.1 - 1.5e-10 40.7 0.2 0.00016 21.4 0.1 3.4 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 CDF39034.1 - 0.00011 22.2 1.7 32 5.6 0.1 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.6 CDF39034.1 - 0.0084 16.1 7.0 2.9 8.2 0.0 6.1 8 0 0 8 8 8 1 Leucine Rich repeat LRR_9 PF14580.6 CDF39034.1 - 0.029 13.9 0.0 4.9 6.6 0.0 3.1 1 1 1 2 2 2 0 Leucine-rich repeat G_glu_transpept PF01019.21 CDF39035.1 - 7.7e-136 453.8 0.4 8.7e-136 453.7 0.4 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase PPDK_N PF01326.19 CDF39037.1 - 2.6e-23 82.8 4.8 3e-16 59.6 0.0 4.3 2 1 1 3 3 3 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain DUF5401 PF17380.2 CDF39037.1 - 0.02 13.0 9.0 0.031 12.4 9.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF1943 PF09172.11 CDF39037.1 - 0.33 10.1 3.3 0.55 9.4 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Phage_Gp23 PF10669.9 CDF39037.1 - 0.58 10.5 12.0 1.6 9.1 12.0 1.7 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) AAA_23 PF13476.6 CDF39037.1 - 3 8.3 8.0 1.5 9.3 4.9 1.9 2 0 0 2 2 2 0 AAA domain Casc1_N PF15927.5 CDF39037.1 - 5.7 6.6 17.0 1.4e+02 2.0 19.4 2.0 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus HTH_Tnp_Tc3_1 PF11427.8 CDF39040.1 - 1.4e-11 44.1 0.0 2.7e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF39040.1 - 1.3e-07 31.2 0.7 1.3e-07 31.2 0.7 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 CDF39040.1 - 2.4e-06 28.0 5.8 0.0031 18.1 0.9 2.5 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 CDF39040.1 - 0.0024 17.6 0.5 0.054 13.3 0.1 2.6 2 0 0 2 2 2 1 Homeodomain-like domain MDMPI_N PF11716.8 CDF39040.1 - 0.04 14.6 0.0 0.064 13.9 0.0 1.4 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain HTH_29 PF13551.6 CDF39040.1 - 0.9 9.6 4.3 4.1 7.5 3.2 2.6 2 1 0 2 2 2 0 Winged helix-turn helix PAP2 PF01569.21 CDF39041.1 - 0.013 15.3 0.5 0.14 12.0 0.5 2.1 1 1 0 1 1 1 0 PAP2 superfamily VF530 PF09905.9 CDF39041.1 - 0.078 13.2 0.0 0.33 11.1 0.0 2.0 2 0 0 2 2 2 0 DNA-binding protein VF530 N6_N4_Mtase PF01555.18 CDF39043.1 - 1.8e-13 50.8 0.0 5.3e-12 45.9 0.0 2.2 1 1 0 1 1 1 1 DNA methylase N6-adenineMlase PF10237.9 CDF39043.1 - 0.0053 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase UPF0020 PF01170.18 CDF39043.1 - 0.066 12.9 0.1 0.65 9.6 0.0 2.4 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 MethyltransfD12 PF02086.15 CDF39043.1 - 0.13 12.0 0.1 3.8 7.1 0.0 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase DEAD PF00270.29 CDF39044.1 - 4.5e-05 23.3 0.1 0.00011 22.1 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Acetyltransf_8 PF13523.6 CDF39044.1 - 0.09 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AMP-binding PF00501.28 CDF39046.1 - 1.4e-73 248.0 0.8 3.1e-39 134.8 0.1 2.2 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CDF39046.1 - 3.4e-07 31.1 1.1 1.1e-06 29.5 0.4 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PAF PF15715.5 CDF39047.1 - 0.021 15.4 2.2 0.031 14.9 2.2 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain PAF PF15715.5 CDF39048.1 - 0.021 15.4 2.2 0.031 14.9 2.2 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Sigma70_r2 PF04542.14 CDF39049.1 - 0.026 14.3 0.6 0.071 12.9 0.1 2.0 2 0 0 2 2 2 0 Sigma-70 region 2 ADH_N_2 PF16884.5 CDF39050.1 - 1.3e-24 86.2 0.0 3.3e-24 84.9 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CDF39050.1 - 1.7e-16 60.4 0.3 3.3e-16 59.5 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDF39050.1 - 7.4e-11 43.2 0.0 1.3e-10 42.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SOR_SNZ PF01680.17 CDF39050.1 - 0.0097 15.7 0.9 0.68 9.7 0.1 2.2 2 0 0 2 2 2 2 SOR/SNZ family DREPP PF05558.12 CDF39050.1 - 0.22 11.4 0.0 0.34 10.8 0.0 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide PUF PF00806.19 CDF39050.1 - 0.3 10.9 0.5 0.69 9.7 0.2 1.7 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Paf67 PF10255.9 CDF39054.1 - 1.3e-139 465.7 1.1 1.6e-139 465.4 1.1 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 CDF39054.1 - 0.02 15.0 0.1 0.058 13.5 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat PCI PF01399.27 CDF39054.1 - 0.076 13.5 0.6 0.24 11.9 0.2 2.0 2 0 0 2 2 2 0 PCI domain TPR_1 PF00515.28 CDF39054.1 - 0.12 12.3 0.1 0.38 10.7 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat STE3 PF02076.15 CDF39055.1 - 0.02 14.1 0.0 0.021 14.0 0.0 1.0 1 0 0 1 1 1 0 Pheromone A receptor Methyltransf_23 PF13489.6 CDF39058.1 - 3.1e-07 30.4 0.0 4.9e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF39058.1 - 3.9e-07 30.7 0.0 4.5e-06 27.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF39058.1 - 3.7e-05 24.4 0.0 6.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF39058.1 - 0.00044 20.9 0.0 0.0015 19.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39058.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 CDF39058.1 - 0.04 13.2 0.0 0.071 12.4 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain NodS PF05401.11 CDF39058.1 - 0.12 12.0 0.0 0.3 10.7 0.0 1.6 2 0 0 2 2 2 0 Nodulation protein S (NodS) MetW PF07021.12 CDF39058.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Queuosine_synth PF02547.15 CDF39059.1 - 5.9e-42 143.9 0.0 7.2e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Queuosine biosynthesis protein DUF2336 PF10098.9 CDF39059.1 - 0.011 15.2 0.3 0.13 11.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2336) PrmA PF06325.13 CDF39060.1 - 9.5e-09 35.1 0.0 1e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 CDF39060.1 - 6.9e-07 29.2 0.0 7.9e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF39060.1 - 1.1e-06 29.2 0.1 1.6e-06 28.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF39060.1 - 8.2e-06 25.5 0.0 1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CDF39060.1 - 2.1e-05 24.4 0.0 2.5e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 CDF39060.1 - 0.00013 22.0 0.0 0.00016 21.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDF39060.1 - 0.00023 20.6 0.0 0.00029 20.2 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 CDF39060.1 - 0.0055 17.3 0.0 0.0074 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CDF39060.1 - 0.0074 15.4 0.0 0.0084 15.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 CDF39060.1 - 0.019 14.9 0.0 0.022 14.8 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39060.1 - 0.055 13.3 0.1 0.067 13.0 0.1 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CDF39060.1 - 0.058 13.1 0.0 0.065 13.0 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase DOT1 PF08123.13 CDF39060.1 - 0.067 12.7 0.0 0.071 12.6 0.0 1.1 1 0 0 1 1 1 0 Histone methylation protein DOT1 MetW PF07021.12 CDF39060.1 - 0.08 12.5 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CxC4 PF18717.1 CDF39066.1 - 3.3e-05 23.8 0.3 3.3e-05 23.8 0.3 2.1 2 1 0 2 2 2 1 CxC4 like cysteine cluster associated with KDZ transposases CxC3 PF18804.1 CDF39066.1 - 0.02 14.7 0.8 0.02 14.7 0.8 2.5 4 0 0 4 4 4 0 CxC3 like cysteine cluster associated with KDZ transposases Integrase_H2C2 PF17921.1 CDF39069.1 - 3.8e-17 62.1 0.4 8.6e-17 61.0 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF39069.1 - 1.9e-12 47.4 0.0 3.8e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDF39069.1 - 7.7e-08 32.3 0.0 2.9e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF39069.1 - 1.3e-07 31.8 0.0 3.7e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 CDF39069.1 - 6.5e-06 26.3 0.2 1.6e-05 25.0 0.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger MscL PF01741.18 CDF39071.1 - 1.7e-20 73.5 2.6 2.3e-20 73.1 2.6 1.2 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL DUF2417 PF10329.9 CDF39071.1 - 0.52 9.7 5.5 1.4 8.3 5.6 1.6 1 1 0 1 1 1 0 Region of unknown function (DUF2417) Mito_carr PF00153.27 CDF39073.1 - 5.8e-21 74.2 0.4 1.6e-14 53.5 0.2 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein Aminotran_5 PF00266.19 CDF39075.1 - 2.4e-30 105.8 0.0 3.2e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V PQQ_2 PF13360.6 CDF39078.1 - 0.00015 21.4 3.0 0.00067 19.3 2.4 2.2 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 CDF39078.1 - 0.00028 20.6 1.3 0.21 11.6 0.0 2.8 2 0 0 2 2 2 2 PQQ enzyme repeat WD40 PF00400.32 CDF39078.1 - 0.00033 21.4 5.2 0.017 16.0 0.0 3.6 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39078.1 - 0.00085 19.6 1.2 4.2 7.7 0.0 3.4 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain ApbE PF02424.15 CDF39079.1 - 1.1e-37 130.0 0.1 3.7e-37 128.3 0.0 1.9 2 0 0 2 2 2 1 ApbE family Flavin_Reduct PF01613.18 CDF39079.1 - 1.5e-08 34.8 1.1 1.5e-08 34.8 1.1 2.7 3 1 0 3 3 3 1 Flavin reductase like domain DrrA_P4M PF14860.6 CDF39083.1 - 0.11 12.3 0.3 0.12 12.3 0.3 1.1 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain His_biosynth PF00977.21 CDF39085.1 - 7.6e-47 159.7 2.9 8.1e-46 156.3 2.9 2.3 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 CDF39085.1 - 6.1e-16 58.8 0.0 9.4e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CDF39085.1 - 0.0019 17.8 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain NMO PF03060.15 CDF39085.1 - 0.03 13.7 1.6 0.066 12.6 0.2 2.0 2 0 0 2 2 2 0 Nitronate monooxygenase Agenet PF05641.12 CDF39085.1 - 0.11 13.0 0.0 16 6.1 0.0 2.9 3 0 0 3 3 3 0 Agenet domain TIM PF00121.18 CDF39086.1 - 4.5e-80 268.5 0.0 5.2e-80 268.3 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase LSM PF01423.22 CDF39087.1 - 7.2e-22 76.9 0.0 8.2e-22 76.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDF39087.1 - 0.015 15.5 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Trs65 PF12735.7 CDF39088.1 - 0.00051 19.5 0.1 0.25 10.7 0.0 2.8 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 PIF1 PF05970.14 CDF39089.1 - 3.4e-77 260.1 0.1 7.3e-52 176.7 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF39089.1 - 3e-46 158.0 0.0 7.5e-46 156.7 0.0 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF39089.1 - 8.5e-12 45.2 0.0 1.7e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF39089.1 - 0.01 13.8 0.0 0.017 13.1 0.0 1.2 1 0 0 1 1 1 0 Helicase AAA_19 PF13245.6 CDF39089.1 - 0.021 15.2 0.0 0.058 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain PAF-AH_p_II PF03403.13 CDF39090.1 - 0.1 11.1 0.0 0.1 11.1 0.0 1.0 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Inositol_P PF00459.25 CDF39091.1 - 6.9e-29 101.2 0.0 7.7e-29 101.0 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family SMC_N PF02463.19 CDF39092.1 - 1.5e-20 73.6 0.0 3.3e-20 72.5 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDF39092.1 - 7.1e-14 52.8 1.9 7.1e-14 52.8 1.9 4.9 2 2 1 4 4 2 1 AAA domain AAA_13 PF13166.6 CDF39092.1 - 0.00097 17.9 8.0 0.00097 17.9 8.0 5.1 3 2 1 5 5 5 2 AAA domain ATG16 PF08614.11 CDF39092.1 - 0.0015 18.8 5.3 0.0015 18.8 5.3 5.4 2 2 3 5 5 4 1 Autophagy protein 16 (ATG16) GAS PF13851.6 CDF39092.1 - 0.0046 16.3 2.6 0.0046 16.3 2.6 5.1 3 1 0 4 4 3 2 Growth-arrest specific micro-tubule binding HrpB7 PF09486.10 CDF39092.1 - 0.0068 16.8 1.6 0.0068 16.8 1.6 6.1 3 2 3 6 6 4 1 Bacterial type III secretion protein (HrpB7) AAA_29 PF13555.6 CDF39092.1 - 0.0069 16.1 0.0 0.021 14.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3450 PF11932.8 CDF39092.1 - 0.0074 15.6 1.3 0.0074 15.6 1.3 5.1 3 1 1 5 5 5 3 Protein of unknown function (DUF3450) SbcCD_C PF13558.6 CDF39092.1 - 0.064 13.5 0.0 0.25 11.6 0.0 2.0 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FlaC_arch PF05377.11 CDF39092.1 - 0.76 10.2 13.0 1.9 8.9 0.6 5.6 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 CDF39092.1 - 0.88 10.1 64.3 0.023 15.2 6.4 5.4 3 1 1 4 4 3 0 Apg6 coiled-coil region AAA_21 PF13304.6 CDF39092.1 - 2.5 7.8 11.7 0.39 10.5 0.4 3.7 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Fez1 PF06818.15 CDF39092.1 - 3.1 8.2 66.1 0.12 12.8 15.9 4.6 3 1 1 4 4 3 0 Fez1 Tektin PF03148.14 CDF39092.1 - 3.8 6.2 55.1 0.0035 16.2 26.6 3.4 2 1 0 3 3 3 0 Tektin family WD40 PF00400.32 CDF39093.1 - 6.1e-24 83.8 2.3 8e-07 29.7 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat BBS2_Mid PF14783.6 CDF39093.1 - 0.00052 20.0 0.0 0.16 12.0 0.0 3.1 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 CDF39093.1 - 0.001 19.3 0.1 0.041 14.2 0.1 3.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF39093.1 - 0.17 10.5 0.1 0.33 9.6 0.1 1.5 1 1 0 1 1 1 0 Nucleoporin Nup120/160 PALP PF00291.25 CDF39096.1 - 1.6e-33 116.4 0.3 2e-33 116.1 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Hydrolase_3 PF08282.12 CDF39098.1 - 7.6e-10 38.9 0.0 1.1e-08 35.1 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDF39098.1 - 0.03 13.8 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase NRBF2 PF08961.10 CDF39099.1 - 0.0053 16.4 4.0 0.0082 15.8 4.0 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator Takusan PF04822.13 CDF39099.1 - 0.0062 16.4 1.5 0.013 15.4 1.5 1.6 1 0 0 1 1 1 1 Takusan TSC22 PF01166.18 CDF39099.1 - 0.022 15.1 0.9 0.049 13.9 0.9 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family bZIP_1 PF00170.21 CDF39099.1 - 0.026 14.6 18.5 0.026 14.6 18.5 1.9 2 0 0 2 2 2 0 bZIP transcription factor IATP PF04568.12 CDF39099.1 - 0.069 13.6 1.9 0.12 12.8 1.9 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP XRCC4 PF06632.12 CDF39099.1 - 0.079 11.8 8.7 0.11 11.3 8.7 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 YabA PF06156.13 CDF39099.1 - 0.087 13.5 2.3 0.2 12.3 2.3 1.6 1 0 0 1 1 1 0 Initiation control protein YabA GvpL_GvpF PF06386.11 CDF39099.1 - 0.13 12.1 1.7 0.2 11.5 1.7 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF CREPT PF16566.5 CDF39099.1 - 0.14 12.3 5.4 0.25 11.5 5.4 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour TMEM51 PF15345.6 CDF39099.1 - 1.2 8.9 5.0 1.8 8.3 5.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 TPR_14 PF13428.6 CDF39100.1 - 7e-37 123.0 57.5 0.00011 22.7 0.5 16.6 8 5 9 17 17 17 10 Tetratricopeptide repeat TPR_2 PF07719.17 CDF39100.1 - 4.6e-36 120.0 29.2 0.0024 17.9 0.0 15.8 16 0 0 16 16 16 7 Tetratricopeptide repeat TPR_17 PF13431.6 CDF39100.1 - 7.1e-21 73.0 6.9 0.0044 17.3 0.0 11.0 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 CDF39100.1 - 9e-21 74.2 40.8 0.0018 18.7 3.2 11.7 10 2 2 12 12 12 7 Tetratricopeptide repeat TPR_1 PF00515.28 CDF39100.1 - 1e-20 72.6 6.7 0.02 14.7 0.0 11.5 13 0 0 13 13 12 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF39100.1 - 8.2e-19 67.7 42.5 0.004 17.4 1.4 12.7 8 4 5 13 13 13 8 Tetratricopeptide repeat TPR_8 PF13181.6 CDF39100.1 - 2.2e-18 64.9 7.5 0.011 15.8 0.0 12.6 15 0 0 15 15 13 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDF39100.1 - 6.4e-18 64.2 6.6 0.0022 17.7 0.0 9.8 12 0 0 12 12 10 3 TPR repeat TPR_16 PF13432.6 CDF39100.1 - 5.7e-11 42.9 57.4 0.0017 19.0 0.6 12.6 9 3 3 13 13 13 4 Tetratricopeptide repeat TPR_6 PF13174.6 CDF39100.1 - 3.1e-08 33.8 24.9 33 5.4 0.0 12.5 11 1 1 12 12 11 0 Tetratricopeptide repeat FAT PF02259.23 CDF39100.1 - 8.4e-06 25.2 18.5 0.037 13.3 0.2 6.4 4 1 1 6 6 6 3 FAT domain Mad3_BUB1_I PF08311.12 CDF39100.1 - 6.4e-05 22.9 10.4 0.31 11.0 0.1 7.5 8 2 1 9 9 8 1 Mad3/BUB1 homology region 1 Suf PF05843.14 CDF39100.1 - 0.0017 18.4 0.0 11 5.9 0.1 4.6 5 1 0 5 5 5 0 Suppressor of forked protein (Suf) TPR_7 PF13176.6 CDF39100.1 - 0.029 14.4 23.5 16 5.8 0.2 10.6 11 1 1 12 12 12 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CDF39100.1 - 0.029 13.8 0.6 0.092 12.1 0.5 1.9 1 1 0 1 1 1 0 Coatomer epsilon subunit ChAPs PF09295.10 CDF39100.1 - 0.045 12.7 0.0 0.33 9.9 0.0 2.1 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) PPR PF01535.20 CDF39100.1 - 0.094 13.0 10.7 25 5.4 0.0 8.2 10 0 0 10 10 9 0 PPR repeat TPR_9 PF13371.6 CDF39100.1 - 0.11 12.7 35.2 1.3 9.2 0.1 8.7 6 3 5 11 11 11 0 Tetratricopeptide repeat DUF3887 PF13026.6 CDF39100.1 - 0.11 13.3 1.6 8.4 7.3 0.3 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3887) Sel1 PF08238.12 CDF39100.1 - 0.14 12.9 9.9 3.6 8.4 0.8 6.1 6 0 0 6 6 5 0 Sel1 repeat DUF2802 PF10975.8 CDF39100.1 - 0.19 11.9 3.5 0.46 10.6 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) PPR_1 PF12854.7 CDF39100.1 - 0.22 11.3 9.5 14 5.5 0.1 6.7 8 0 0 8 8 7 0 PPR repeat DUF349 PF03993.12 CDF39100.1 - 1.1 9.6 5.9 1.1 9.6 0.4 3.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) MerR-DNA-bind PF09278.11 CDF39100.1 - 1.5 9.4 5.8 58 4.3 0.1 3.4 2 0 0 2 2 2 0 MerR, DNA binding NSF PF02071.20 CDF39100.1 - 1.6 9.8 5.9 1.1e+02 4.3 0.0 5.3 5 0 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat CDC73_C PF05179.14 CDF39102.1 - 4.5e-38 130.4 0.9 7.9e-38 129.6 0.0 1.8 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 CDF39102.1 - 1.3e-11 44.4 0.3 2.2e-11 43.6 0.3 1.4 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal DUF321 PF03778.13 CDF39102.1 - 0.43 10.3 2.0 0.85 9.3 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF321) Hydrolase_4 PF12146.8 CDF39103.1 - 2.7e-10 39.9 0.0 4.6e-06 26.1 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF39103.1 - 2.4e-07 30.7 0.1 0.0085 15.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold FmiP_Thoc5 PF09766.9 CDF39104.1 - 2.1e-32 112.8 1.7 6.5e-16 58.6 0.0 3.0 2 1 1 3 3 3 2 Fms-interacting protein/Thoc5 Lzipper-MIP1 PF14389.6 CDF39104.1 - 0.51 10.7 3.8 3.9 7.8 0.1 3.6 3 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Atg14 PF10186.9 CDF39104.1 - 0.81 8.7 4.1 1.4 7.9 4.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Peptidase_M32 PF02074.15 CDF39105.1 - 5.9e-173 576.1 0.0 6.7e-173 575.9 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Phage_min_cap2 PF06152.11 CDF39105.1 - 0.025 13.5 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 Phage minor capsid protein 2 Peripla_BP_2 PF01497.18 CDF39106.1 - 0.00062 19.4 0.0 0.00095 18.8 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Sec63 PF02889.16 CDF39107.1 - 1.1e-21 77.2 0.0 1.6e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CDF39107.1 - 1.4e-20 73.8 0.0 2.4e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF39107.1 - 9e-11 42.1 0.0 1.7e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDF39107.1 - 4.7e-06 26.9 0.0 4.9e-05 23.6 0.0 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA PF00004.29 CDF39107.1 - 0.0064 16.9 0.5 0.32 11.4 0.3 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) HHH_5 PF14520.6 CDF39107.1 - 0.021 15.4 0.1 0.056 14.1 0.1 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain AAA_22 PF13401.6 CDF39107.1 - 0.035 14.4 0.0 0.13 12.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 CDF39107.1 - 0.091 11.8 0.0 0.3 10.1 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein BTB PF00651.31 CDF39108.1 - 1.2e-08 35.2 0.0 1.9e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CDF39108.1 - 0.0065 16.6 0.1 0.013 15.6 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch DUF4194 PF13835.6 CDF39108.1 - 0.03 14.1 0.1 0.055 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) Helicase_C PF00271.31 CDF39109.1 - 4.2e-13 49.6 0.0 1e-12 48.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF39109.1 - 1.2e-09 38.2 0.0 3.4e-09 36.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 CDF39109.1 - 2.8e-06 27.7 0.2 1.9e-05 25.0 0.2 2.5 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 CDF39109.1 - 0.0051 16.8 0.0 0.017 15.1 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit N6_N4_Mtase PF01555.18 CDF39110.1 - 3.7e-14 53.0 0.0 1.6e-12 47.6 0.0 2.2 1 1 0 1 1 1 1 DNA methylase SET PF00856.28 CDF39110.1 - 0.0067 16.8 0.0 0.036 14.4 0.0 2.2 1 1 0 1 1 1 1 SET domain N6-adenineMlase PF10237.9 CDF39110.1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase MethyltransfD12 PF02086.15 CDF39110.1 - 0.16 11.6 0.1 4.5 6.9 0.0 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Arm PF00514.23 CDF39111.1 - 6.7e-10 38.7 9.9 1.4e-06 28.1 0.0 6.3 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CDF39111.1 - 5.1e-07 29.4 11.5 0.25 11.7 0.1 6.7 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 CDF39111.1 - 3.1e-05 24.1 3.3 1.3 9.0 0.6 3.4 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDF39111.1 - 5.3e-05 23.5 11.4 0.027 14.8 0.4 5.7 2 1 0 5 5 5 1 HEAT repeats V-ATPase_H_C PF11698.8 CDF39111.1 - 0.00012 22.1 1.2 0.036 14.2 0.1 3.2 2 1 1 3 3 3 1 V-ATPase subunit H CLASP_N PF12348.8 CDF39111.1 - 0.00022 20.9 0.3 0.0016 18.0 0.1 2.5 3 1 1 4 4 4 1 CLASP N terminal DUF3361 PF11841.8 CDF39111.1 - 0.0024 17.8 0.5 0.012 15.6 0.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3361) DCB PF16213.5 CDF39111.1 - 0.015 15.0 0.3 4.7 6.8 0.0 2.4 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Adaptin_N PF01602.20 CDF39111.1 - 0.018 13.6 1.5 0.13 10.8 0.2 2.6 2 1 1 3 3 3 0 Adaptin N terminal region Atx10homo_assoc PF09759.9 CDF39111.1 - 0.03 14.3 0.2 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 CDF39111.1 - 0.041 14.4 14.3 2.1 8.9 0.1 5.9 5 2 0 6 6 6 0 HEAT-like repeat Ric8 PF10165.9 CDF39111.1 - 0.3 10.1 3.7 0.18 10.8 0.8 1.9 2 1 0 2 2 2 0 Guanine nucleotide exchange factor synembryn Helicase_C PF00271.31 CDF39114.1 - 2.3e-14 53.7 0.0 6.8e-14 52.2 0.0 1.8 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CDF39114.1 - 6.4e-08 32.3 10.7 1.3e-07 31.3 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF39114.1 - 3.1e-07 30.2 10.2 6e-07 29.2 10.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF39114.1 - 4.8e-07 30.0 11.4 9.1e-07 29.1 11.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDF39114.1 - 7.3e-07 29.0 9.3 1.4e-06 28.1 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 CDF39114.1 - 1.4e-06 27.3 0.0 2.4e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CDF39114.1 - 3.9e-05 23.6 6.8 0.00011 22.1 7.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CDF39114.1 - 0.00074 19.3 10.0 0.0016 18.2 10.0 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 CDF39114.1 - 0.0012 18.8 10.8 0.004 17.1 10.9 1.8 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF39114.1 - 0.067 13.1 11.4 0.13 12.2 6.0 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDF39114.1 - 0.069 13.3 9.7 0.15 12.3 9.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING ERCC3_RAD25_C PF16203.5 CDF39114.1 - 0.099 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-Nse PF11789.8 CDF39114.1 - 0.11 12.3 4.9 0.25 11.2 4.9 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 CDF39114.1 - 0.12 12.5 7.0 0.34 11.1 7.0 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 Rad50_zn_hook PF04423.14 CDF39114.1 - 0.18 11.7 1.2 6.1 6.8 0.2 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_6 PF14835.6 CDF39114.1 - 0.95 9.4 8.4 0.45 10.4 6.0 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Plasmod_MYXSPDY PF07981.11 CDF39118.1 - 0.01 15.8 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Plasmodium repeat_MYXSPDY DDE_3 PF13358.6 CDF39120.1 - 4.7e-15 55.6 0.0 8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF39120.1 - 1.9e-07 30.8 0.0 3.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_23 PF13384.6 CDF39120.1 - 0.016 15.0 0.0 0.044 13.6 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF39120.1 - 0.018 15.3 0.8 0.04 14.2 0.8 1.7 1 0 0 1 1 1 0 Transposase HTH_38 PF13936.6 CDF39120.1 - 0.026 14.3 0.7 0.087 12.6 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.6 CDF39120.1 - 0.048 14.3 5.7 2.5 8.8 2.5 3.1 1 1 1 2 2 2 0 Homeodomain-like domain Pkinase PF00069.25 CDF39122.1 - 8.9e-55 185.9 0.0 1.4e-54 185.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39122.1 - 1.1e-31 110.0 0.0 1.6e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF39122.1 - 0.00066 19.1 0.1 0.0024 17.2 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDF39122.1 - 0.0077 15.0 0.0 0.0077 15.0 0.0 3.2 3 1 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 CDF39122.1 - 0.025 13.9 0.0 0.065 12.6 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF39122.1 - 0.033 14.1 0.3 0.44 10.4 0.0 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family FSA_C PF10479.9 CDF39122.1 - 0.96 7.5 4.7 1.9 6.6 4.7 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Peptidase_M24 PF00557.24 CDF39124.1 - 8.4e-47 159.6 0.1 1e-46 159.3 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 CDF39124.1 - 2e-17 63.2 5.6 3.5e-17 62.4 5.6 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 CDF39124.1 - 0.00045 20.3 4.7 0.0011 19.0 4.7 1.7 1 0 0 1 1 1 1 MYND finger RRM_1 PF00076.22 CDF39125.1 - 2e-42 142.8 0.0 8.2e-19 67.2 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF39125.1 - 6.2e-08 32.4 0.0 0.017 15.0 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RBM39linker PF15519.6 CDF39125.1 - 6e-07 30.5 0.7 6.4e-05 24.0 0.7 2.9 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_8 PF11835.8 CDF39125.1 - 8.7e-05 22.7 0.0 0.037 14.2 0.0 2.6 2 0 0 2 2 2 2 RRM-like domain Nup35_RRM_2 PF14605.6 CDF39125.1 - 0.0081 16.1 0.0 0.59 10.2 0.0 2.6 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 CDF39125.1 - 0.037 13.9 0.0 0.67 9.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) PHM7_cyt PF14703.6 CDF39125.1 - 0.24 11.6 0.2 33 4.7 0.0 3.0 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Cation_ATPase_C PF00689.21 CDF39126.1 - 0.0033 17.2 3.7 0.0033 17.2 3.7 1.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus SPRY PF00622.28 CDF39129.1 - 2.4e-24 85.8 0.1 3.6e-24 85.2 0.1 1.3 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 CDF39129.1 - 1.3e-23 83.5 0.3 3.9e-23 82.0 0.1 1.8 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CDF39129.1 - 1.7e-05 24.6 0.1 5.1e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 LisH DSPc PF00782.20 CDF39130.1 - 1.2e-20 73.7 0.0 1.5e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDF39130.1 - 0.037 13.6 0.0 0.054 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Peptidase_S9_N PF02897.15 CDF39131.1 - 9.6e-82 275.0 6.3 1.2e-81 274.7 6.3 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CDF39131.1 - 6.8e-45 153.1 0.0 1.7e-44 151.8 0.0 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF1647 PF07801.11 CDF39131.1 - 0.039 13.7 0.4 10 5.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) WD40 PF00400.32 CDF39132.1 - 8e-37 124.6 32.2 1.8e-06 28.5 1.6 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat TIR_2 PF13676.6 CDF39132.1 - 2.6e-17 63.5 0.0 2.2e-16 60.6 0.0 2.6 3 0 0 3 3 3 1 TIR domain NB-ARC PF00931.22 CDF39132.1 - 8.3e-16 57.9 0.0 1.9e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF39132.1 - 6e-08 32.7 0.0 1.6e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF39132.1 - 0.00025 21.3 6.5 0.22 11.8 0.1 4.8 1 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 CDF39132.1 - 0.00093 19.5 0.0 0.0024 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Nup160 PF11715.8 CDF39132.1 - 0.0066 15.2 8.0 12 4.4 0.0 6.3 5 1 2 7 7 7 1 Nucleoporin Nup120/160 TIR-like PF10137.9 CDF39132.1 - 0.096 12.7 0.0 0.38 10.7 0.0 2.1 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Radial_spoke_3 PF06098.11 CDF39134.1 - 0.024 13.9 0.2 0.027 13.8 0.2 1.0 1 0 0 1 1 1 0 Radial spoke protein 3 Y_phosphatase2 PF03162.13 CDF39134.1 - 0.079 12.5 0.0 0.086 12.4 0.0 1.0 1 0 0 1 1 1 0 Tyrosine phosphatase family CCT PF06203.14 CDF39138.1 - 7.7e-13 48.3 2.1 7.7e-13 48.3 2.1 1.6 2 0 0 2 2 2 1 CCT motif WD40 PF00400.32 CDF39140.1 - 5.9e-139 447.8 133.3 1.7e-06 28.6 0.9 24.4 24 0 0 24 24 24 23 WD domain, G-beta repeat TIR_2 PF13676.6 CDF39140.1 - 2.4e-17 63.6 0.0 1.8e-16 60.8 0.0 2.6 2 0 0 2 2 2 1 TIR domain NB-ARC PF00931.22 CDF39140.1 - 1e-16 60.9 0.0 3.5e-16 59.2 0.0 1.9 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF39140.1 - 7.7e-13 48.6 45.3 0.39 11.1 0.0 16.0 1 1 20 21 21 21 4 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.20 CDF39140.1 - 3.2e-07 30.3 0.0 6.8e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 TIR domain Nup160 PF11715.8 CDF39140.1 - 4e-05 22.5 50.2 4.6 5.8 0.0 19.9 17 5 5 24 24 24 3 Nucleoporin Nup120/160 AAA_22 PF13401.6 CDF39140.1 - 0.0045 17.3 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain APAF1_C PF17908.1 CDF39140.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain TIR-like PF10137.9 CDF39140.1 - 0.15 12.0 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain TAL_FSA PF00923.19 CDF39142.1 - 1.3e-91 306.9 0.0 1.5e-91 306.7 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase ODV-E18 PF10717.9 CDF39143.1 - 0.07 13.0 0.1 0.082 12.8 0.1 1.1 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 GCV_H PF01597.19 CDF39145.1 - 0.5 10.3 6.9 5.5 6.9 0.1 3.6 2 1 2 4 4 4 0 Glycine cleavage H-protein PolyA_pol PF01743.20 CDF39146.1 - 3.1e-23 82.6 0.1 2.1e-22 79.9 0.1 2.1 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CDF39146.1 - 3.6e-05 23.4 0.2 0.00035 20.3 0.0 2.6 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 CDF39146.1 - 0.015 15.3 0.4 0.053 13.5 0.1 2.0 2 0 0 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative DUF2993 PF11209.8 CDF39146.1 - 0.77 10.0 3.6 9.8 6.4 3.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2993) NUMOD3 PF07460.11 CDF39147.1 - 0.066 13.5 6.6 0.43 10.8 0.7 3.5 1 1 2 3 3 3 0 NUMOD3 motif (2 copies) DUF5094 PF17015.5 CDF39148.1 - 0.027 14.6 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) SNF2_N PF00176.23 CDF39149.1 - 4.8e-52 176.8 0.0 7.8e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF39149.1 - 3.4e-16 59.6 0.0 2e-15 57.1 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF39149.1 - 5.3e-09 36.3 0.0 2.5e-08 34.1 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2439 PF10382.9 CDF39149.1 - 2.2e-08 34.3 0.5 9.4e-08 32.3 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) DEAD PF00270.29 CDF39149.1 - 7.3e-07 29.1 0.0 1.4e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Fructosamin_kin PF03881.14 CDF39151.1 - 2.4e-78 263.3 0.0 2.7e-78 263.1 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CDF39151.1 - 4.6e-07 30.0 0.0 6.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family WD-3 PF09765.9 CDF39152.1 - 2.5e-68 230.5 0.1 3e-68 230.3 0.1 1.0 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 CDF39152.1 - 1.7e-24 85.8 1.3 3.6e-24 84.7 1.3 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 CDF39152.1 - 0.0011 19.2 3.4 0.0039 17.5 3.4 2.0 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF39152.1 - 0.079 13.3 1.0 0.25 11.6 1.0 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain PHD PF00628.29 CDF39152.1 - 0.079 12.9 2.5 0.2 11.6 2.5 1.8 1 1 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 CDF39152.1 - 0.087 13.1 1.8 0.37 11.1 1.9 2.0 1 1 1 2 2 2 0 PHD-like zinc-binding domain UQ_con PF00179.26 CDF39152.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Zf_RING PF16744.5 CDF39152.1 - 0.67 10.1 3.3 4.1 7.6 1.8 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 CDF39152.1 - 2.5 8.1 4.6 0.76 9.8 1.2 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 RT_RNaseH PF17917.1 CDF39153.1 - 5.3e-34 116.7 0.0 2.1e-33 114.7 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF39153.1 - 2.9e-32 110.6 0.0 6.3e-32 109.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF39153.1 - 1.7e-20 73.4 0.0 3.7e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF39153.1 - 6.8e-16 58.1 0.1 1.7e-15 56.9 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF39153.1 - 7.1e-10 38.6 0.0 1.3e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF39153.1 - 0.00078 19.2 0.1 0.0053 16.5 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDF39153.1 - 0.00089 19.4 0.0 0.0021 18.3 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Sel1 PF08238.12 CDF39166.1 - 5.2e-28 96.9 0.6 1e-05 26.1 0.0 6.2 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.6 CDF39166.1 - 0.16 12.7 5.9 26 5.7 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat DDE_3 PF13358.6 CDF39167.1 - 2.8e-18 66.1 0.0 3.5e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease zinc_ribbon_10 PF10058.9 CDF39168.1 - 0.067 12.9 0.2 0.082 12.6 0.2 1.2 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Ras PF00071.22 CDF39170.1 - 6.2e-48 162.5 0.0 7.5e-48 162.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF39170.1 - 4.7e-19 68.8 0.0 1.6e-18 67.0 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF39170.1 - 9.1e-05 22.0 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDF39170.1 - 0.00024 20.7 0.0 0.00036 20.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDF39170.1 - 0.019 15.1 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF39170.1 - 0.078 12.3 0.0 0.11 11.8 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RhoGAP PF00620.27 CDF39171.1 - 1.6e-16 60.5 0.0 2.9e-16 59.6 0.0 1.4 1 1 0 1 1 1 1 RhoGAP domain NinF PF05810.12 CDF39171.1 - 0.054 13.4 0.1 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 NinF protein IP_trans PF02121.18 CDF39172.1 - 6e-92 307.7 0.3 6.8e-92 307.5 0.3 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein GATA PF00320.27 CDF39173.1 - 2e-17 62.5 3.5 5.2e-17 61.2 3.5 1.8 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 CDF39173.1 - 0.0084 16.2 0.1 0.023 14.8 0.1 1.8 1 0 0 1 1 1 1 Zinc ribbon domain UPF0193 PF05250.11 CDF39173.1 - 0.39 10.5 1.7 1.5 8.6 0.4 2.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0193) SNF2_N PF00176.23 CDF39174.1 - 1.1e-71 241.4 1.5 2e-71 240.5 1.5 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF39174.1 - 5.5e-21 75.0 0.0 2.7e-19 69.5 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF39174.1 - 1.6e-07 31.5 0.0 4.5e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CDF39174.1 - 1e-06 28.1 0.1 3.1e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SnAC PF14619.6 CDF39174.1 - 0.016 15.8 1.7 0.016 15.8 1.7 3.6 5 0 0 5 5 5 0 Snf2-ATP coupling, chromatin remodelling complex SWI2_SNF2 PF18766.1 CDF39174.1 - 0.025 14.3 0.0 0.085 12.5 0.0 1.9 1 1 0 1 1 1 0 SWI2/SNF2 ATPase Nucleotid_trans PF03407.16 CDF39175.1 - 3.8e-16 59.7 0.0 8.2e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DRIM PF07539.12 CDF39177.1 - 5.7e-29 100.9 7.0 8.7e-29 100.3 3.3 3.1 2 0 0 2 2 2 1 Down-regulated in metastasis UNC45-central PF11701.8 CDF39177.1 - 0.0011 18.9 4.3 2.8 7.9 0.1 5.4 5 0 0 5 5 5 2 Myosin-binding striated muscle assembly central ParcG PF10274.9 CDF39177.1 - 0.014 15.5 0.4 0.36 10.9 0.0 3.0 3 0 0 3 3 3 0 Parkin co-regulated protein DUF1678 PF07913.11 CDF39177.1 - 0.11 12.2 2.0 3.8 7.2 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1678) UPF0004 PF00919.20 CDF39178.1 - 2.3e-28 98.1 0.0 7e-28 96.6 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 CDF39178.1 - 2e-25 90.1 0.6 3.5e-25 89.3 0.1 1.6 2 0 0 2 2 2 1 Radical SAM superfamily TRAM PF01938.20 CDF39178.1 - 4.2e-13 49.1 2.0 8.6e-13 48.1 2.0 1.6 1 0 0 1 1 1 1 TRAM domain TRAM_2 PF18693.1 CDF39178.1 - 0.031 14.4 3.0 0.12 12.6 3.0 2.0 1 1 0 1 1 1 0 TRAM domain Flu_M1_C PF08289.11 CDF39178.1 - 0.078 13.2 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain TraT PF05818.12 CDF39178.1 - 0.093 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Rotamase PF00639.21 CDF39178.1 - 0.14 13.1 0.0 0.75 10.8 0.0 2.3 1 1 0 1 1 1 0 PPIC-type PPIASE domain SIS PF01380.22 CDF39179.1 - 6.8e-52 174.8 0.2 2.4e-28 98.6 0.1 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CDF39179.1 - 2.1e-16 60.3 0.0 4.8e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDF39179.1 - 1.4e-11 44.4 0.0 2.7e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CDF39179.1 - 1e-05 24.6 0.0 1.9e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 CDF39179.1 - 0.002 18.2 0.0 0.018 15.1 0.0 2.3 2 0 0 2 2 2 1 SIS domain CRCB PF02537.15 CDF39180.1 - 1.7e-25 89.1 23.4 3e-13 49.9 8.9 2.3 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Helicase_C PF00271.31 CDF39181.1 - 9e-14 51.8 0.0 2.3e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF39181.1 - 9.5e-11 41.8 0.0 3.2e-10 40.0 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase OrsD PF12013.8 CDF39181.1 - 2.3e-07 31.3 0.7 3.9e-06 27.3 0.7 2.9 1 1 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D ResIII PF04851.15 CDF39181.1 - 9.1e-05 22.5 0.0 0.00026 21.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Phage_integrase PF00589.22 CDF39181.1 - 0.0054 16.5 0.1 0.08 12.7 0.0 2.8 3 1 0 3 3 3 1 Phage integrase family zf_C2H2_10 PF18414.1 CDF39181.1 - 0.019 14.5 2.2 0.13 11.8 0.8 3.1 2 0 0 2 2 2 0 C2H2 type zinc-finger Glycos_transf_2 PF00535.26 CDF39182.1 - 2e-20 73.3 0.0 4.9e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 CDF39182.1 - 5.9e-09 35.5 2.1 8.2e-09 35.0 0.1 2.2 3 0 0 3 3 3 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDF39182.1 - 2.3e-06 27.3 0.0 0.041 13.4 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 CDF39182.1 - 0.00037 20.4 0.1 0.0021 18.0 0.0 2.1 2 1 0 2 2 2 1 Glycosyltransferase like family 2 LIN52 PF10044.9 CDF39183.1 - 0.014 16.1 0.0 0.02 15.6 0.0 1.4 1 1 0 1 1 1 0 Retinal tissue protein WD40 PF00400.32 CDF39184.1 - 2.9e-29 100.7 8.5 0.00017 22.3 0.0 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39184.1 - 9.1e-09 35.5 0.1 0.27 11.5 0.0 5.8 3 3 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Bromodomain PF00439.25 CDF39184.1 - 2.6e-07 30.6 0.0 4.8e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Auxin_resp PF06507.13 CDF39184.1 - 8.6e-07 29.1 0.0 2.1e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Auxin response factor Nup160 PF11715.8 CDF39184.1 - 3.9e-05 22.5 0.7 0.4 9.3 0.0 3.7 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF39184.1 - 0.0017 17.4 0.1 14 4.5 0.0 3.7 3 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Methyltransf_12 PF08242.12 CDF39186.1 - 6.7e-19 68.5 0.1 1.7e-18 67.2 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39186.1 - 8.1e-19 67.9 0.0 1.2e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF39186.1 - 4.7e-18 65.6 0.0 9.3e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF39186.1 - 4.9e-17 62.4 0.0 1e-16 61.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF39186.1 - 1e-16 61.3 0.0 2.8e-16 59.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF39186.1 - 3.8e-08 33.0 0.0 6.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CDF39186.1 - 1.7e-06 27.7 0.0 3.6e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 CDF39186.1 - 2.4e-05 23.4 0.0 3.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 CDF39186.1 - 3.5e-05 23.2 0.0 5.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 CDF39186.1 - 0.00069 20.6 0.0 0.0017 19.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDF39186.1 - 0.0016 18.2 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) rRNA_methylase PF06962.12 CDF39186.1 - 0.019 14.9 0.0 0.61 10.1 0.0 2.3 1 1 0 1 1 1 0 Putative rRNA methylase Methyltransf_32 PF13679.6 CDF39186.1 - 0.028 14.4 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 CDF39186.1 - 0.036 13.7 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) TehB PF03848.14 CDF39186.1 - 0.058 12.8 0.0 0.09 12.2 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 CDF39186.1 - 0.11 11.9 0.0 0.32 10.4 0.0 1.8 1 1 0 1 1 1 0 Putative methyltransferase CheR PF01739.18 CDF39186.1 - 0.22 11.0 0.0 11 5.5 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain OTU PF02338.19 CDF39187.1 - 8.1e-16 58.7 0.0 1.5e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CDF39187.1 - 0.0014 18.2 0.1 0.94 8.9 0.0 2.3 2 1 0 2 2 2 2 Peptidase C65 Otubain RNA_pol PF00940.19 CDF39188.1 - 2.5e-145 484.4 0.0 8e-145 482.8 0.0 1.7 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CDF39188.1 - 2.5e-46 158.6 0.3 5.8e-46 157.4 0.1 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal RVT_N PF13655.6 CDF39188.1 - 0.08 13.2 1.3 0.14 12.5 0.1 2.0 2 0 0 2 2 2 0 N-terminal domain of reverse transcriptase AOX PF01786.17 CDF39189.1 - 1.1e-70 237.6 0.7 1.4e-70 237.2 0.7 1.1 1 0 0 1 1 1 1 Alternative oxidase COQ7 PF03232.13 CDF39189.1 - 0.00025 20.9 0.1 0.00048 19.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 NADH-u_ox-rdase PF10785.9 CDF39189.1 - 0.013 16.2 0.3 0.038 14.7 0.2 1.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF5399 PF17377.2 CDF39189.1 - 0.018 14.9 0.1 0.03 14.2 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5399) CAP_C PF08603.11 CDF39190.1 - 3.3e-52 176.3 7.3 4e-52 176.0 7.3 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.19 CDF39190.1 - 0.00046 19.8 6.0 0.00046 19.8 6.0 2.7 1 1 1 3 3 3 1 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.12 CDF39190.1 - 0.0014 18.4 3.2 0.0024 17.6 3.2 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Sde2_N_Ubi PF13019.6 CDF39191.1 - 1.7e-18 67.0 1.1 2.5e-18 66.5 1.0 1.5 1 1 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Adeno_terminal PF02459.15 CDF39191.1 - 0.11 10.9 1.5 0.14 10.6 1.5 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Sec23_trunk PF04811.15 CDF39192.1 - 4.1e-34 118.2 0.0 6.4e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CDF39192.1 - 2.6e-17 62.5 0.1 4.9e-17 61.6 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDF39192.1 - 1e-10 41.4 1.4 1e-10 41.4 1.4 1.8 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 CDF39192.1 - 1.9e-08 34.9 0.0 4.6e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 CDF39192.1 - 0.0045 16.8 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Q_salvage PF10343.9 CDF39193.1 - 7.1e-100 334.2 0.0 8.4e-100 334.0 0.0 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family AAA PF00004.29 CDF39194.1 - 2.3e-40 138.1 0.0 2.1e-29 102.6 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF39194.1 - 7.7e-09 36.2 9.5 0.016 15.6 0.1 4.4 2 2 2 4 4 4 3 AAA ATPase domain AAA_22 PF13401.6 CDF39194.1 - 2.8e-07 30.9 2.2 0.081 13.2 0.0 4.2 2 2 2 4 4 4 2 AAA domain AAA_14 PF13173.6 CDF39194.1 - 5.2e-06 26.5 0.0 0.033 14.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 CDF39194.1 - 1e-05 24.9 0.0 0.0039 16.4 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_5 PF07728.14 CDF39194.1 - 0.0012 18.9 0.0 0.023 14.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CDF39194.1 - 0.0018 18.5 0.1 0.28 11.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CDF39194.1 - 0.0037 16.8 0.0 0.092 12.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 CDF39194.1 - 0.0084 15.9 0.1 0.37 10.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_lid_3 PF17862.1 CDF39194.1 - 0.011 15.5 0.1 0.011 15.5 0.1 1.9 2 0 0 2 2 2 0 AAA+ lid domain Viral_helicase1 PF01443.18 CDF39194.1 - 0.012 15.4 0.0 0.1 12.3 0.0 2.2 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 CDF39194.1 - 0.019 14.7 0.0 0.067 12.9 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 CDF39194.1 - 0.039 13.9 0.0 1.2 9.1 0.0 2.6 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CDF39194.1 - 0.049 13.6 0.0 0.45 10.5 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CDF39194.1 - 0.061 13.7 0.0 5 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDF39194.1 - 0.088 13.4 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 CDF39194.1 - 0.14 11.5 0.1 0.75 9.1 0.0 1.9 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_25 PF13481.6 CDF39194.1 - 0.19 11.3 4.3 9.7 5.7 0.1 2.9 2 1 0 2 2 2 0 AAA domain HisG PF01634.18 CDF39195.1 - 6.1e-38 130.3 0.0 8.3e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 CDF39195.1 - 2.8e-14 53.0 0.0 5.6e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 HisG, C-terminal domain HLH PF00010.26 CDF39202.1 - 0.0011 18.9 4.8 0.0023 17.9 4.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DDE_3 PF13358.6 CDF39203.1 - 6.5e-16 58.4 0.0 9e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease 6PGD PF00393.19 CDF39204.1 - 0.088 12.2 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 6-phosphogluconate dehydrogenase, C-terminal domain Bestrophin PF01062.21 CDF39205.1 - 2.6e-10 40.2 0.0 3.1e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Bestrophin PF01062.21 CDF39206.1 - 0.0056 16.1 0.1 0.0069 15.8 0.1 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Pre-PUA PF17832.1 CDF39209.1 - 6.3e-24 84.5 0.0 9.7e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CDF39209.1 - 2.4e-14 53.0 0.9 3.9e-14 52.4 0.9 1.4 1 0 0 1 1 1 1 PUA domain PP2C PF00481.21 CDF39214.1 - 6e-44 150.6 0.0 1.1e-43 149.7 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDF39214.1 - 0.041 13.8 0.0 0.1 12.5 0.0 1.6 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) AAA PF00004.29 CDF39216.1 - 1.6e-36 125.6 0.0 2.8e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF39216.1 - 3.5e-09 36.3 0.0 8.5e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 CDF39216.1 - 1.6e-06 28.5 0.7 0.0024 18.1 0.1 3.6 2 1 2 4 4 4 1 AAA domain AAA_5 PF07728.14 CDF39216.1 - 3.2e-06 27.2 0.3 2.5e-05 24.3 0.2 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDF39216.1 - 3.2e-06 27.0 0.0 5.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF39216.1 - 1.8e-05 25.2 1.5 0.011 16.1 0.1 2.9 3 0 0 3 3 2 1 AAA ATPase domain TIP49 PF06068.13 CDF39216.1 - 4.4e-05 22.8 0.0 0.00013 21.3 0.0 1.6 1 1 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 CDF39216.1 - 7.9e-05 22.8 0.2 0.00058 20.0 0.0 2.4 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 CDF39216.1 - 0.00011 22.8 0.0 0.00031 21.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDF39216.1 - 0.0002 21.1 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 CDF39216.1 - 0.00024 21.3 0.0 0.00049 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 CDF39216.1 - 0.00028 20.9 0.0 0.00056 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CDF39216.1 - 0.00045 19.7 0.0 0.51 9.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein Mg_chelatase PF01078.21 CDF39216.1 - 0.00099 18.5 0.2 0.0025 17.2 0.2 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDF39216.1 - 0.0029 17.4 0.0 0.0066 16.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDF39216.1 - 0.0036 17.6 0.2 0.012 15.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF39216.1 - 0.0061 16.5 0.4 0.2 11.5 0.1 2.3 1 1 1 2 2 2 1 NACHT domain AAA_30 PF13604.6 CDF39216.1 - 0.0068 16.1 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDF39216.1 - 0.0083 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TsaE PF02367.17 CDF39216.1 - 0.013 15.5 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDF39216.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CDF39216.1 - 0.025 14.1 0.0 0.064 12.8 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 CDF39216.1 - 0.028 13.8 0.2 2 7.7 0.1 2.2 1 1 1 2 2 2 0 KaiC Sigma54_activ_2 PF14532.6 CDF39216.1 - 0.029 14.5 0.0 0.063 13.4 0.0 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 CDF39216.1 - 0.032 13.5 0.0 0.072 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 CDF39216.1 - 0.043 13.7 0.1 0.16 11.8 0.0 1.7 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 CDF39216.1 - 0.053 13.1 0.4 0.2 11.2 0.2 2.1 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CDF39216.1 - 0.057 12.5 0.0 0.092 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 IPT PF01745.16 CDF39216.1 - 0.073 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Viral_helicase1 PF01443.18 CDF39216.1 - 0.083 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 CDF39216.1 - 0.097 12.4 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_17 PF13207.6 CDF39216.1 - 0.1 13.0 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Guanylate_kin PF00625.21 CDF39216.1 - 0.11 12.1 0.2 1.6 8.4 0.0 2.6 3 0 0 3 3 3 0 Guanylate kinase AAA_3 PF07726.11 CDF39216.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CDF39216.1 - 0.18 12.3 0.1 0.46 11.0 0.1 1.7 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 CDF39216.1 - 0.19 11.4 0.0 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 CDF39217.1 - 1.5e-46 158.0 0.1 1.9e-46 157.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CDF39217.1 - 2.2e-19 69.6 0.0 2.9e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF39217.1 - 3.4e-16 59.6 0.0 6e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDF39217.1 - 2.4e-09 36.9 0.0 3.6e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDF39217.1 - 1.5e-08 34.7 0.1 7e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF39217.1 - 4.2e-08 32.8 0.0 5.1e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CDF39217.1 - 2e-07 30.5 0.4 1.4e-05 24.4 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 CDF39217.1 - 7.1e-06 25.7 0.4 0.00046 19.8 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Actin PF00022.19 CDF39218.1 - 3.7e-102 342.0 0.0 5.5e-102 341.4 0.0 1.2 1 0 0 1 1 1 1 Actin V-SNARE_C PF12352.8 CDF39219.1 - 6.6e-16 58.3 4.2 9.6e-14 51.4 3.5 2.6 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 CDF39219.1 - 8.9e-12 45.2 2.2 1.6e-11 44.4 0.7 2.1 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 CDF39219.1 - 1.6e-07 31.2 1.4 4e-07 29.8 0.1 2.3 2 2 0 2 2 2 1 Sec20 WEMBL PF05701.11 CDF39219.1 - 0.0005 18.9 2.6 0.00086 18.1 2.6 1.3 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF4407 PF14362.6 CDF39219.1 - 0.0007 19.0 2.5 0.00083 18.8 2.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) THOC7 PF05615.13 CDF39219.1 - 0.07 13.4 5.1 0.13 12.5 0.9 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 Sec8_exocyst PF04048.14 CDF39219.1 - 0.11 12.3 5.7 4.5 7.2 0.2 3.0 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Spc7 PF08317.11 CDF39219.1 - 1.4 7.7 6.1 10 4.9 0.1 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 CDF39219.1 - 3 6.8 7.7 4.3 6.3 7.5 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FA_hydroxylase PF04116.13 CDF39221.1 - 6e-23 81.7 17.3 6e-23 81.7 17.3 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Yippee-Mis18 PF03226.14 CDF39222.1 - 6.3e-08 32.8 0.0 0.013 15.7 0.0 2.3 2 0 0 2 2 2 2 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly F-box-like PF12937.7 CDF39222.1 - 0.0014 18.5 0.2 0.003 17.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like SelR PF01641.18 CDF39222.1 - 0.026 14.6 0.1 5.5 7.1 0.0 3.1 3 0 0 3 3 3 0 SelR domain F-box PF00646.33 CDF39222.1 - 0.079 12.9 0.1 0.2 11.6 0.1 1.8 1 0 0 1 1 1 0 F-box domain HECT_2 PF09814.9 CDF39222.1 - 0.2 10.5 0.9 46 2.7 0.0 3.1 2 1 0 3 3 3 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF1523 PF07509.11 CDF39224.1 - 0.086 12.2 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Apq12 PF12716.7 CDF39225.1 - 0.23 11.4 5.7 0.55 10.2 5.7 1.5 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis GTP_EFTU PF00009.27 CDF39226.1 - 6e-58 195.6 0.1 8.1e-58 195.2 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDF39226.1 - 9.7e-29 99.9 0.1 2.1e-28 98.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDF39226.1 - 1.5e-15 57.3 3.9 3.4e-15 56.2 3.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF39226.1 - 8.3e-06 25.9 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF39226.1 - 0.016 15.1 0.0 0.054 13.4 0.0 1.7 1 1 1 2 2 2 0 RsgA GTPase cobW PF02492.19 CDF39226.1 - 0.017 14.7 0.3 0.037 13.6 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Lsm_C PF14894.6 CDF39226.1 - 0.16 11.8 0.9 0.36 10.6 0.9 1.5 1 0 0 1 1 1 0 Lsm C-terminal RRM_1 PF00076.22 CDF39227.1 - 7.8e-22 76.9 0.0 1.6e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zinc_ribbon_4 PF13717.6 CDF39227.1 - 1.9e-05 24.4 0.1 4e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-CSL PF05207.13 CDF39227.1 - 0.066 13.0 0.6 0.54 10.0 0.5 2.1 2 0 0 2 2 2 0 CSL zinc finger DUF3866 PF12982.7 CDF39227.1 - 0.08 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3866) Ank_2 PF12796.7 CDF39229.1 - 1.3e-98 323.7 14.2 2.8e-18 66.3 0.0 10.3 5 3 6 11 11 11 11 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDF39229.1 - 6.4e-75 238.1 28.8 5.8e-07 29.3 0.0 20.1 21 0 0 21 21 20 15 Ankyrin repeat Ank_4 PF13637.6 CDF39229.1 - 6.6e-75 246.6 23.0 1e-08 35.5 0.1 14.1 5 3 10 16 16 16 14 Ankyrin repeats (many copies) Ank PF00023.30 CDF39229.1 - 1.8e-72 236.8 39.4 8.1e-08 32.4 0.1 18.9 19 1 0 19 19 19 14 Ankyrin repeat Ank_5 PF13857.6 CDF39229.1 - 2.6e-66 218.8 29.7 2.9e-10 40.2 0.2 15.3 9 3 7 16 16 16 14 Ankyrin repeats (many copies) zf-RING_2 PF13639.6 CDF39229.1 - 1.5e-09 38.1 4.7 4.6e-09 36.5 4.7 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDF39229.1 - 9.2e-07 28.5 5.3 1.3e-06 28.0 2.4 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 CDF39229.1 - 3.1e-05 24.2 5.6 0.00016 21.9 5.6 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDF39229.1 - 4.1e-05 23.3 3.9 0.00012 21.9 3.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF39229.1 - 6.8e-05 22.7 3.2 0.00022 21.0 3.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDF39229.1 - 0.0002 21.4 0.7 0.00057 19.9 0.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger GST_N_5 PF18485.1 CDF39229.1 - 0.0051 17.1 0.6 16 5.9 0.0 4.6 5 0 0 5 5 3 0 Glutathione S-transferase, N-terminal domain zf-RING_5 PF14634.6 CDF39229.1 - 0.011 15.7 2.5 0.011 15.7 2.5 2.2 2 0 0 2 2 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 CDF39229.1 - 0.011 15.6 3.7 0.011 15.6 3.7 2.6 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDF39229.1 - 0.048 13.5 2.0 0.14 12.0 2.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF39229.1 - 0.075 13.1 4.8 0.29 11.2 4.8 2.1 1 0 0 1 1 1 0 RING-type zinc-finger VWA_3_C PF18571.1 CDF39229.1 - 0.097 12.6 0.2 0.7 9.8 0.1 2.6 2 0 0 2 2 2 0 von Willebrand factor type A C-terminal domain AnkUBD PF18418.1 CDF39229.1 - 0.12 12.5 0.0 39 4.5 0.0 3.1 2 0 0 2 2 2 0 Ankyrin ubiquitin-binding domain NmrA PF05368.13 CDF39229.1 - 0.18 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Zn_ribbon_17 PF17120.5 CDF39229.1 - 0.23 11.1 3.0 0.7 9.6 3.0 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type tRNA-synt_2b PF00587.25 CDF39230.1 - 5.5e-42 143.7 0.0 1.2e-41 142.6 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDF39230.1 - 5e-16 58.6 0.3 1.4e-15 57.2 0.3 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 CDF39230.1 - 8.7e-13 48.2 0.0 2.5e-12 46.7 0.0 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain UL42 PF17638.2 CDF39230.1 - 0.00032 20.7 3.2 0.00056 19.9 3.2 1.3 1 0 0 1 1 1 1 HCMV UL42 CAP_N PF01213.19 CDF39230.1 - 8 5.8 6.6 13 5.1 6.6 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal bZIP_1 PF00170.21 CDF39231.1 - 1.1e-06 28.6 16.9 1.8e-06 27.9 16.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor SPATA48 PF15073.6 CDF39231.1 - 0.0099 16.2 0.8 0.0099 16.2 0.8 2.4 2 2 0 2 2 2 1 Spermatogenesis-associated protein 48 bZIP_2 PF07716.15 CDF39231.1 - 0.025 14.7 21.0 0.028 14.5 19.0 2.0 1 1 1 2 2 2 0 Basic region leucine zipper DUF1180 PF06679.12 CDF39231.1 - 0.029 14.8 1.6 0.029 14.8 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF5320 PF17253.2 CDF39231.1 - 0.11 13.5 0.7 0.21 12.7 0.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5320) WD40_alt PF14077.6 CDF39231.1 - 0.5 10.3 1.7 0.56 10.1 0.6 1.6 2 0 0 2 2 2 0 Alternative WD40 repeat motif H_PPase PF03030.16 CDF39232.1 - 3.6e-54 184.5 34.5 9.7e-54 183.1 34.5 1.8 1 1 0 1 1 1 1 Inorganic H+ pyrophosphatase TraA PF05513.11 CDF39232.1 - 0.43 10.9 5.7 7.5 6.9 0.3 3.3 2 0 0 2 2 2 0 TraA Ac76 PF05814.11 CDF39232.1 - 6.6 6.8 6.0 1.2 9.2 0.4 2.6 3 0 0 3 3 3 0 Orf76 (Ac76) ERG4_ERG24 PF01222.17 CDF39234.1 - 6.7e-16 58.1 1.8 7.3e-16 57.9 1.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ERG4_ERG24 PF01222.17 CDF39235.1 - 4.5e-30 104.8 0.8 4.6e-30 104.7 0.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CDF39235.1 - 0.00014 21.4 0.1 0.00018 21.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Pkinase PF00069.25 CDF39240.1 - 6.7e-65 219.1 0.0 8.9e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39240.1 - 1.8e-32 112.7 0.0 2.8e-32 112.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF39240.1 - 2.6e-06 26.6 0.0 3.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF39240.1 - 6.3e-05 22.4 0.0 0.0055 16.1 0.0 2.2 1 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 CDF39240.1 - 0.048 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF39240.1 - 0.24 11.3 0.1 0.24 11.3 0.1 3.0 3 1 1 4 4 4 0 Phosphotransferase enzyme family Malic_M PF03949.15 CDF39241.1 - 1.1e-90 303.5 0.1 1.4e-90 303.1 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CDF39241.1 - 1.1e-63 214.3 0.0 1.8e-63 213.6 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Aminotran_1_2 PF00155.21 CDF39242.1 - 5.6e-57 193.6 0.0 6.5e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDF39242.1 - 2.5e-06 27.1 0.0 4e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CDF39242.1 - 6.4e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CDF39242.1 - 0.0083 14.7 0.0 0.012 14.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDF39242.1 - 0.011 14.8 0.0 0.023 13.7 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V Aminotran_MocR PF12897.7 CDF39242.1 - 0.032 13.0 0.1 0.054 12.3 0.0 1.4 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase Hint_2 PF13403.6 CDF39242.1 - 0.21 11.9 1.3 2.2 8.6 0.1 2.5 3 0 0 3 3 3 0 Hint domain S-AdoMet_synt_C PF02773.16 CDF39243.1 - 9.7e-62 207.0 0.0 1.2e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain SIR2 PF02146.17 CDF39244.1 - 4.2e-52 176.6 0.0 6.2e-52 176.1 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CDF39244.1 - 0.0094 15.7 0.1 4.5 7.0 0.0 2.8 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, central domain MGC-24 PF05283.11 CDF39245.1 - 0.032 14.7 3.2 0.062 13.7 3.2 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Nucleotid_trans PF03407.16 CDF39246.1 - 3.4e-05 23.9 0.2 5.2e-05 23.3 0.2 1.3 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase SNARE_assoc PF09335.11 CDF39247.1 - 2.8e-24 85.9 16.2 9.7e-24 84.2 6.5 2.4 2 1 1 3 3 3 2 SNARE associated Golgi protein Ank_2 PF12796.7 CDF39250.1 - 5.5e-56 187.1 11.1 3.4e-16 59.6 0.1 6.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDF39250.1 - 1.8e-42 143.2 7.0 1.8e-09 37.9 0.2 8.3 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDF39250.1 - 1.1e-34 118.1 7.7 3e-07 30.6 0.0 9.0 2 2 7 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 CDF39250.1 - 1.1e-33 114.1 21.2 8.1e-05 22.9 0.1 11.0 11 0 0 11 11 11 7 Ankyrin repeat Ank_3 PF13606.6 CDF39250.1 - 5.3e-30 100.1 10.6 0.028 14.9 0.0 10.8 11 0 0 11 11 11 9 Ankyrin repeat Arm_3 PF16186.5 CDF39250.1 - 0.0034 16.9 0.0 0.0072 15.9 0.0 1.5 1 0 0 1 1 1 1 Atypical Arm repeat Imm27 PF15590.6 CDF39251.1 - 0.097 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 27 PNTB PF02233.16 CDF39253.1 - 2e-162 541.3 21.8 2e-162 541.3 21.8 2.3 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CDF39253.1 - 6.3e-71 238.1 0.7 1.7e-70 236.7 0.7 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDF39253.1 - 1.9e-37 128.6 2.2 2.7e-37 128.1 0.3 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CDF39253.1 - 8.4e-30 103.1 2.0 8.4e-30 103.1 2.0 5.0 5 1 3 8 8 8 1 4TM region of pyridine nucleotide transhydrogenase, mitoch Pyr_redox_2 PF07992.14 CDF39253.1 - 0.0053 16.0 0.2 0.013 14.8 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF39253.1 - 0.033 13.3 0.2 0.057 12.5 0.2 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CDF39253.1 - 0.036 13.4 0.4 1.2 8.5 0.2 2.8 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CDF39253.1 - 0.051 14.0 0.3 0.51 10.8 0.1 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox PF00070.27 CDF39253.1 - 0.06 13.9 0.7 0.24 12.0 0.7 2.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDF39253.1 - 0.35 11.1 2.0 1.8 8.8 1.1 2.6 1 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain TFIIS_C PF01096.18 CDF39254.1 - 5.4e-19 67.8 6.9 5.4e-19 67.8 6.9 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Elf1 PF05129.13 CDF39254.1 - 0.012 15.6 2.3 0.014 15.5 2.3 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 CDF39254.1 - 0.014 15.3 2.7 1.3 9.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Baculo_LEF5_C PF11792.8 CDF39254.1 - 0.026 14.2 2.4 0.055 13.1 2.4 1.6 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain DUF2250 PF10007.9 CDF39254.1 - 0.14 12.3 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) GTP_EFTU PF00009.27 CDF39257.1 - 1.8e-69 233.2 0.1 2.7e-69 232.6 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDF39257.1 - 4.2e-38 129.9 0.0 9.3e-38 128.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CDF39257.1 - 8.6e-34 115.5 0.1 1.7e-33 114.5 0.1 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDF39257.1 - 2.3e-25 88.5 0.0 8.1e-25 86.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF39257.1 - 6.5e-19 68.1 1.7 1.5e-18 66.9 1.7 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDF39257.1 - 9.9e-08 31.9 0.0 2.3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDF39257.1 - 0.0023 18.0 0.0 0.0064 16.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CDF39257.1 - 0.015 15.2 0.0 0.047 13.6 0.0 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 4 AIG1 PF04548.16 CDF39257.1 - 0.016 14.6 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 AIG1 family HTH_Tnp_Tc5 PF03221.16 CDF39257.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain NAD_binding_5 PF07994.12 CDF39258.1 - 3.8e-140 466.8 0.0 5.1e-140 466.4 0.0 1.2 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 CDF39258.1 - 8.1e-45 151.5 0.3 1.5e-44 150.7 0.3 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase GRA6 PF05084.13 CDF39259.1 - 0.15 12.0 0.2 0.15 12.0 0.2 1.0 1 0 0 1 1 1 0 Granule antigen protein (GRA6) RskA PF10099.9 CDF39260.1 - 0.0074 16.6 1.7 0.0076 16.6 1.7 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TPPK_C PF12555.8 CDF39260.1 - 0.14 12.2 3.4 0.31 11.1 2.6 1.9 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal HAD_2 PF13419.6 CDF39262.1 - 4.7e-22 78.9 0.0 7.2e-22 78.3 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF39262.1 - 2.2e-15 57.6 0.1 2e-14 54.4 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF39262.1 - 3.3e-06 27.6 0.1 1.1e-05 25.9 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF39262.1 - 3.4e-06 27.0 0.0 5.8e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 CDF39262.1 - 4.8e-06 26.4 0.0 0.00015 21.6 0.0 2.0 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase Nup54 PF13874.6 CDF39266.1 - 4.6e-26 91.6 2.2 4.6e-26 91.6 2.2 1.7 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 V-SNARE PF05008.15 CDF39266.1 - 0.077 13.4 1.7 0.26 11.7 0.5 2.4 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Ald_Xan_dh_C2 PF02738.18 CDF39267.1 - 2.1e-80 270.8 0.0 2.6e-80 270.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C2 PF02738.18 CDF39268.1 - 4.3e-33 114.6 0.5 9.6e-33 113.4 0.8 1.4 2 0 0 2 2 2 1 Molybdopterin-binding domain of aldehyde dehydrogenase Lipase_3 PF01764.25 CDF39272.1 - 1.1e-28 99.8 0.0 2.4e-28 98.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CDF39272.1 - 0.0059 17.2 0.2 0.036 14.7 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF2974 PF11187.8 CDF39272.1 - 0.0063 16.1 0.4 1.3 8.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2974) Thioesterase PF00975.20 CDF39272.1 - 0.032 14.3 0.1 0.061 13.4 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain DnaJ PF00226.31 CDF39273.1 - 0.00011 22.2 0.1 0.00021 21.4 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain ATP-synt_E PF05680.12 CDF39273.1 - 0.86 10.0 4.7 1.9 8.8 4.7 1.5 1 0 0 1 1 1 0 ATP synthase E chain Med3 PF11593.8 CDF39273.1 - 4.9 6.2 13.3 0.13 11.5 3.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal SRP68 PF16969.5 CDF39274.1 - 1.9e-61 208.7 6.0 9.8e-61 206.4 6.0 2.0 1 1 0 1 1 1 1 RNA-binding signal recognition particle 68 Totivirus_coat PF05518.11 CDF39274.1 - 0.027 12.6 0.3 0.034 12.2 0.3 1.1 1 0 0 1 1 1 0 Totivirus coat protein GDI PF00996.18 CDF39275.1 - 1.5e-47 162.1 0.0 6.3e-34 117.2 0.0 2.2 2 0 0 2 2 2 2 GDP dissociation inhibitor FAD_binding_8 PF08022.12 CDF39276.1 - 1.5e-17 63.6 0.0 4e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CDF39276.1 - 1.5e-16 60.9 0.2 8.1e-08 32.5 0.0 3.5 3 1 0 3 3 3 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CDF39276.1 - 2.2e-12 47.2 14.6 8.3e-12 45.3 14.6 2.0 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 CDF39276.1 - 0.033 14.8 0.0 5.5 7.7 0.0 3.1 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain SNase PF00565.17 CDF39279.1 - 2.6e-10 40.7 0.0 6.1e-10 39.5 0.0 1.6 1 1 0 1 1 1 1 Staphylococcal nuclease homologue Cation_ATPase PF13246.6 CDF39280.1 - 0.04 14.0 0.0 0.1 12.7 0.0 1.6 2 0 0 2 2 2 0 Cation transport ATPase (P-type) gag_pre-integrs PF13976.6 CDF39280.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 GAG-pre-integrase domain PhoLip_ATPase_C PF16212.5 CDF39281.1 - 7.1e-42 143.9 15.8 3.3e-37 128.6 13.9 2.0 1 1 1 2 2 2 2 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CDF39281.1 - 0.004 17.5 0.1 0.0058 16.9 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF39281.1 - 0.0049 16.6 0.0 0.0063 16.3 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Helicase_C PF00271.31 CDF39284.1 - 5.7e-19 68.5 0.1 1.8e-18 66.9 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CDF39284.1 - 0.0046 16.2 0.0 0.013 14.7 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 CDF39284.1 - 0.041 13.1 0.0 0.074 12.3 0.0 1.4 1 1 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase PALP PF00291.25 CDF39287.1 - 3.9e-43 148.0 0.5 4.6e-43 147.7 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Band_7 PF01145.25 CDF39289.1 - 3.9e-16 59.6 0.4 3.9e-16 59.6 0.4 2.5 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.5 CDF39289.1 - 6.1e-05 23.2 1.8 6.1e-05 23.2 1.8 4.3 2 1 2 4 4 4 2 Flotillin SUIM_assoc PF16619.5 CDF39289.1 - 0.0045 17.0 0.0 5 7.3 5.1 2.4 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Band_7 PF01145.25 CDF39290.1 - 6.1e-11 42.6 0.0 6.1e-11 42.6 0.0 3.0 1 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.5 CDF39290.1 - 9.1e-09 35.5 5.0 9.1e-09 35.5 5.0 2.9 2 1 0 2 2 2 1 Flotillin Ribosomal_S15 PF00312.22 CDF39291.1 - 1.5e-29 102.0 1.7 2.6e-29 101.2 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PGAP1 PF07819.13 CDF39293.1 - 0.2 11.3 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein p450 PF00067.22 CDF39295.1 - 4.6e-52 177.3 0.0 1.6e-46 159.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 FA_desaturase PF00487.24 CDF39296.1 - 8.1e-15 55.3 26.5 1.2e-14 54.8 26.5 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CDF39296.1 - 6.3e-10 39.1 0.1 1.4e-09 38.0 0.1 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AAA PF00004.29 CDF39302.1 - 5.4e-56 188.6 0.0 2.6e-40 137.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF39302.1 - 6.7e-12 45.0 0.0 1.8e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDF39302.1 - 1.3e-09 38.7 0.1 0.0028 18.1 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 CDF39302.1 - 3.1e-09 37.0 0.0 0.00021 21.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDF39302.1 - 4.9e-09 36.5 0.0 1.1e-06 28.9 0.0 3.1 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDF39302.1 - 7.2e-09 36.0 0.8 0.0016 18.7 0.0 3.9 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 CDF39302.1 - 1.2e-08 34.6 0.0 0.00072 18.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 CDF39302.1 - 1.6e-08 34.4 0.0 0.0025 17.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CDF39302.1 - 3.9e-07 30.7 0.0 0.053 14.1 0.0 3.0 2 1 1 3 3 3 2 AAA domain AAA_33 PF13671.6 CDF39302.1 - 4.7e-07 30.1 0.0 0.016 15.3 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_24 PF13479.6 CDF39302.1 - 1.6e-06 28.0 0.0 0.014 15.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CDF39302.1 - 2.1e-06 27.3 0.1 0.0057 16.1 0.1 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CDF39302.1 - 9.4e-06 25.1 0.3 0.012 14.9 0.1 2.9 3 0 0 3 3 2 2 KaiC AAA_28 PF13521.6 CDF39302.1 - 2.3e-05 24.7 0.0 0.046 14.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 CDF39302.1 - 2.4e-05 24.4 0.0 0.00016 21.8 0.0 2.5 2 1 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain IstB_IS21 PF01695.17 CDF39302.1 - 3.8e-05 23.5 0.0 0.2 11.4 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_11 PF13086.6 CDF39302.1 - 4e-05 23.5 0.0 0.33 10.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDF39302.1 - 4.4e-05 23.8 0.0 0.057 13.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 CDF39302.1 - 7.8e-05 22.3 0.1 0.012 15.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 CDF39302.1 - 0.00011 22.0 0.0 0.56 9.9 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 CDF39302.1 - 0.00014 22.4 0.7 0.013 16.0 0.1 2.7 2 1 0 2 2 2 1 ABC transporter AAA_3 PF07726.11 CDF39302.1 - 0.00014 21.7 0.0 0.47 10.3 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 CDF39302.1 - 0.00017 21.1 0.2 0.25 10.8 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.9 CDF39302.1 - 0.0002 20.7 0.5 0.6 9.3 0.0 2.6 2 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 CDF39302.1 - 0.00027 21.0 0.0 0.13 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDF39302.1 - 0.0005 19.8 0.1 1 9.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 CDF39302.1 - 0.0006 19.8 0.9 0.53 10.2 0.0 3.3 3 1 0 3 3 2 1 NACHT domain AAA_25 PF13481.6 CDF39302.1 - 0.00068 19.3 1.4 2 8.0 0.1 3.5 3 1 0 3 3 3 2 AAA domain TsaE PF02367.17 CDF39302.1 - 0.0012 18.8 0.0 0.46 10.5 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CDF39302.1 - 0.0013 19.1 0.1 0.61 10.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CDF39302.1 - 0.0035 17.4 0.0 1 9.3 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Rad17 PF03215.15 CDF39302.1 - 0.0035 17.3 0.1 6.7 6.6 0.0 3.5 3 1 1 4 4 4 0 Rad17 P-loop domain Parvo_NS1 PF01057.17 CDF39302.1 - 0.0061 15.7 0.0 1.2 8.2 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 CDF39302.1 - 0.0077 15.4 0.1 0.61 9.2 0.2 2.3 2 0 0 2 2 2 1 NB-ARC domain DEAD PF00270.29 CDF39302.1 - 0.0084 15.9 0.9 29 4.4 0.0 4.0 3 1 1 4 4 4 0 DEAD/DEAH box helicase Sigma54_activ_2 PF14532.6 CDF39302.1 - 0.011 15.9 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain CDC48_2 PF02933.17 CDF39302.1 - 0.012 15.4 2.2 0.076 12.8 0.1 2.9 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 ATPase_2 PF01637.18 CDF39302.1 - 0.013 15.4 0.9 15 5.4 0.0 3.8 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 CDF39302.1 - 0.015 15.7 0.1 5.4 7.4 0.0 3.1 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 CDF39302.1 - 0.024 13.9 0.1 0.94 8.7 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin IPT PF01745.16 CDF39302.1 - 0.069 12.5 0.1 1.2 8.4 0.0 2.5 3 0 0 3 3 2 0 Isopentenyl transferase Cytidylate_kin PF02224.18 CDF39302.1 - 0.1 12.3 0.0 5.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AAA_29 PF13555.6 CDF39302.1 - 0.11 12.3 0.1 20 5.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 CDF39302.1 - 0.11 12.4 0.1 16 5.4 0.0 2.8 2 0 0 2 2 2 0 NTPase TniB PF05621.11 CDF39302.1 - 0.12 11.8 0.1 5.5 6.4 0.2 3.1 2 1 0 2 2 2 0 Bacterial TniB protein Sgf11 PF08209.11 CDF39303.1 - 1.4e-12 47.0 1.3 2.7e-12 46.0 1.3 1.5 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-CpG_bind_C PF12269.8 CDF39303.1 - 0.0032 17.3 0.0 0.0052 16.6 0.0 1.3 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain N2227 PF07942.12 CDF39305.1 - 5.4e-53 179.9 0.0 7e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 CDF39305.1 - 0.077 13.7 0.1 0.37 11.5 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain Terminase_GpA PF05876.12 CDF39306.1 - 0.11 11.0 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Lar_restr_allev PF14354.6 CDF39306.1 - 0.12 12.8 0.4 0.26 11.7 0.4 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-CCHC_5 PF14787.6 CDF39306.1 - 0.27 11.0 0.2 0.27 11.0 0.2 2.7 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger zf-C4_Topoisom PF01396.19 CDF39306.1 - 0.5 10.2 2.7 13 5.6 0.3 2.5 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger SHOCT PF09851.9 CDF39306.1 - 1.3 8.9 4.5 15 5.5 0.2 2.5 2 0 0 2 2 2 0 Short C-terminal domain zf-C2H2_jaz PF12171.8 CDF39309.1 - 0.0048 17.2 0.2 0.01 16.1 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CDF39309.1 - 0.0085 16.8 0.1 0.03 15.1 0.1 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CDF39309.1 - 0.024 15.1 0.1 0.074 13.5 0.1 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 CDF39309.1 - 0.025 14.8 0.2 0.064 13.6 0.2 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 CDF39309.1 - 0.11 13.0 0.2 0.26 11.8 0.2 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-H2C2_2 PF13465.6 CDF39309.1 - 0.18 12.3 0.3 0.4 11.2 0.3 1.6 1 0 0 1 1 1 0 Zinc-finger double domain RNA_pol_I_A49 PF06870.12 CDF39315.1 - 6.4e-40 137.2 0.0 8e-40 136.9 0.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor UPF0047 PF01894.17 CDF39316.1 - 9.3e-26 90.2 0.0 1.1e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 NADHdh_A3 PF14987.6 CDF39317.1 - 1.3e-05 25.3 0.1 1.6e-05 25.1 0.1 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 alpha subcomplex subunit 3 Abhydrolase_2 PF02230.16 CDF39318.1 - 4.6e-38 131.2 0.0 6.5e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CDF39318.1 - 7.8e-06 25.7 0.1 9.2e-05 22.2 0.1 2.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDF39318.1 - 4e-05 23.0 0.0 0.0013 18.0 0.0 2.2 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CDF39318.1 - 4.8e-05 23.3 0.0 0.0023 17.8 0.0 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDF39318.1 - 0.00046 19.7 0.0 0.12 11.8 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CDF39318.1 - 0.0016 19.1 0.0 0.0098 16.5 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 CDF39318.1 - 0.0018 18.0 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 CDF39318.1 - 0.0024 17.5 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family AXE1 PF05448.12 CDF39318.1 - 0.075 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF1690 PF07956.11 CDF39319.1 - 4.3e-06 27.2 2.0 5.4e-06 26.9 2.0 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) RRM_1 PF00076.22 CDF39320.1 - 8.7e-15 54.3 0.0 1.1e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDF39320.1 - 0.00079 19.0 0.0 0.0008 19.0 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Formyl_trans_N PF00551.19 CDF39321.1 - 6.3e-40 136.8 0.0 7.7e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase DUF2969 PF11184.8 CDF39321.1 - 0.15 12.5 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) UL11 PF11094.8 CDF39321.1 - 0.46 10.4 2.1 1.6 8.7 1.1 2.2 2 0 0 2 2 2 0 Membrane-associated tegument protein MutS_V PF00488.21 CDF39323.1 - 7.1e-33 114.2 0.0 2.5e-30 105.9 0.0 2.1 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CDF39324.1 - 2.3e-18 67.1 0.0 2.9e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CDF39324.1 - 0.00039 20.7 0.0 0.0008 19.7 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV zf-trcl PF13451.6 CDF39324.1 - 0.15 12.0 0.1 0.43 10.5 0.1 1.7 1 0 0 1 1 1 0 Probable zinc-ribbon domain DDT PF02791.17 CDF39326.1 - 1.3e-11 44.7 0.1 2.1e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 DDT domain WSD PF15613.6 CDF39326.1 - 3.4e-09 37.1 2.1 3.4e-09 37.1 2.1 4.2 3 2 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif RT_RNaseH_2 PF17919.1 CDF39331.1 - 3.2e-34 117.0 0.0 8.2e-34 115.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF39331.1 - 3.7e-30 104.3 0.0 8e-30 103.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF39331.1 - 7.1e-11 42.0 0.6 6.2e-06 25.9 0.2 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CDF39331.1 - 0.00018 21.7 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain CLP_protease PF00574.23 CDF39332.1 - 2.8e-78 262.0 0.0 3.7e-78 261.6 0.0 1.1 1 0 0 1 1 1 1 Clp protease Rubis-subs-bind PF09273.11 CDF39333.1 - 1.1e-19 71.3 0.1 1.9e-19 70.6 0.1 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 CDF39333.1 - 2.4e-11 44.3 0.0 6.4e-11 42.9 0.0 1.7 2 0 0 2 2 2 1 SET domain PPR_2 PF13041.6 CDF39337.1 - 5.5e-05 23.3 0.0 1.6 9.0 0.0 4.0 4 0 0 4 4 4 2 PPR repeat family PPR_long PF17177.4 CDF39337.1 - 0.00046 19.6 0.2 0.0024 17.3 0.0 2.2 4 0 0 4 4 4 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 CDF39337.1 - 0.014 15.4 0.0 0.075 13.1 0.0 2.3 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.20 CDF39337.1 - 0.085 13.1 1.2 1e+02 3.5 0.1 4.4 4 1 0 4 4 4 0 PPR repeat Pet127 PF08634.10 CDF39338.1 - 1.5e-77 260.7 0.4 2.2e-77 260.2 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 TauD PF02668.16 CDF39338.1 - 0.075 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family Pkinase_Tyr PF07714.17 CDF39339.1 - 4.9e-33 114.5 0.0 8.7e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF39339.1 - 2.2e-30 105.9 0.0 4.4e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain LRR_6 PF13516.6 CDF39340.1 - 8e-15 53.6 5.0 0.28 11.4 0.0 8.7 10 0 0 10 10 10 4 Leucine Rich repeat LRR_4 PF12799.7 CDF39340.1 - 4.3e-13 49.2 1.0 0.01 16.3 0.0 6.2 3 1 4 8 8 8 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CDF39340.1 - 3.2e-08 33.3 1.0 3.2e-08 33.3 1.0 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CDF39340.1 - 7.5e-07 28.9 2.0 7.5e-07 28.9 2.0 2.7 3 0 0 3 3 3 1 F-box domain LRR_8 PF13855.6 CDF39340.1 - 3.8e-05 23.4 1.8 6.4 6.6 0.0 5.8 5 2 1 6 6 6 2 Leucine rich repeat LRR_2 PF07723.13 CDF39340.1 - 0.00055 20.5 3.0 3.1 8.6 0.0 4.4 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_1 PF00560.33 CDF39340.1 - 0.0016 18.7 10.9 8.3 7.4 0.1 7.5 7 1 0 7 7 7 1 Leucine Rich Repeat DUF1699 PF08004.11 CDF39340.1 - 0.037 13.7 0.5 5.8 6.6 0.0 4.2 2 2 3 6 6 6 0 Protein of unknown function (DUF1699) Dimerisation2 PF16864.5 CDF39340.1 - 0.15 12.1 0.1 12 6.0 0.0 3.1 3 0 0 3 3 3 0 Dimerisation domain Colipase PF01114.18 CDF39340.1 - 5.2 6.8 6.5 1.7 8.4 1.4 2.6 2 0 0 2 2 2 0 Colipase, N-terminal domain Rhodanese PF00581.20 CDF39341.1 - 9e-12 45.5 0.0 1.1e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Ribonuc_red_sm PF00268.21 CDF39342.1 - 1.9e-77 260.5 0.3 8.2e-76 255.1 0.3 2.2 1 1 0 1 1 1 1 Ribonucleotide reductase, small chain Peptidase_M3 PF01432.20 CDF39342.1 - 2.3e-15 56.8 0.2 1.4e-14 54.3 0.2 1.9 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 CDF39342.1 - 1e-08 35.3 0.0 4.5e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Oligopeptidase F zf-CCCH_2 PF14608.6 CDF39343.1 - 0.043 14.3 2.2 0.077 13.5 2.2 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Hyaluronidase_1 PF07212.11 CDF39343.1 - 0.044 13.1 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Hyaluronidase protein (HylP) zf_CCCH_4 PF18345.1 CDF39343.1 - 0.18 11.9 4.7 0.31 11.2 4.7 1.4 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 CDF39343.1 - 0.22 11.5 3.8 0.43 10.6 3.8 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TLD PF07534.16 CDF39345.1 - 3.3e-08 33.9 0.0 6.1e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 TLD Toprim_N PF08275.11 CDF39346.1 - 1.1e-25 90.1 0.0 5.8e-25 87.8 0.0 2.0 2 0 0 2 2 2 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.20 CDF39346.1 - 5.5e-17 61.4 0.0 1.6e-16 59.9 0.0 1.8 1 0 0 1 1 1 1 CHC2 zinc finger Toprim_2 PF13155.6 CDF39346.1 - 2.2e-12 47.2 0.0 5e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 Toprim-like Toprim_4 PF13662.6 CDF39346.1 - 5.4e-10 39.6 0.3 1.4e-09 38.3 0.1 1.8 2 0 0 2 2 2 1 Toprim domain Toprim PF01751.22 CDF39346.1 - 0.0046 17.2 0.0 0.016 15.5 0.0 2.0 1 0 0 1 1 1 1 Toprim domain DUF4939 PF16297.5 CDF39346.1 - 0.048 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) ArsA_ATPase PF02374.15 CDF39347.1 - 5.7e-80 268.7 0.0 7e-80 268.5 0.0 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 CDF39347.1 - 1.1e-10 41.6 0.0 2.3e-10 40.6 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDF39347.1 - 5.8e-07 29.6 0.1 1.2e-06 28.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain ParA PF10609.9 CDF39347.1 - 1.2e-06 28.1 5.0 0.00019 20.9 1.6 2.4 2 1 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDF39347.1 - 0.00026 20.5 0.1 0.00045 19.8 0.1 1.3 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 CDF39347.1 - 0.00082 18.9 0.1 0.002 17.6 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 CDF39347.1 - 0.015 15.0 0.3 0.044 13.4 0.2 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Snf7 PF03357.21 CDF39347.1 - 0.031 13.9 0.1 0.031 13.9 0.1 2.1 2 0 0 2 2 2 0 Snf7 PhoH PF02562.16 CDF39347.1 - 0.052 13.0 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ATP_bind_1 PF03029.17 CDF39347.1 - 0.063 13.1 0.2 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 CDF39347.1 - 0.063 12.6 0.1 0.33 10.2 0.1 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 CDF39347.1 - 0.076 13.4 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain LpxK PF02606.14 CDF39347.1 - 0.12 11.4 0.4 0.58 9.2 0.1 1.9 2 0 0 2 2 2 0 Tetraacyldisaccharide-1-P 4'-kinase DnaB_C PF03796.15 CDF39347.1 - 0.14 11.5 0.1 0.24 10.7 0.1 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain eIF-5_eIF-2B PF01873.17 CDF39349.1 - 7.9e-35 119.3 0.1 1.8e-34 118.1 0.1 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 CDF39349.1 - 1.2e-12 47.8 6.2 1.2e-12 47.8 6.2 2.9 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon HNF-1_N PF04814.13 CDF39349.1 - 0.1 13.2 1.8 0.17 12.5 1.8 1.3 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus GATA PF00320.27 CDF39349.1 - 0.69 9.6 4.2 1.4 8.6 4.2 1.5 1 0 0 1 1 1 0 GATA zinc finger TRM13 PF05206.14 CDF39350.1 - 3.8e-37 128.2 0.1 3.3e-29 102.2 0.1 2.1 1 1 1 2 2 2 2 Methyltransferase TRM13 DZR PF12773.7 CDF39350.1 - 0.022 14.8 2.4 0.04 13.9 1.3 2.0 2 0 0 2 2 2 0 Double zinc ribbon zf-TRM13_CCCH PF11722.8 CDF39350.1 - 0.038 13.7 0.8 0.038 13.7 0.8 1.9 2 0 0 2 2 2 0 CCCH zinc finger in TRM13 protein Methyltransf_4 PF02390.17 CDF39351.1 - 2.1e-44 151.0 0.0 2.5e-44 150.8 0.0 1.0 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 CDF39351.1 - 2.5e-06 28.1 0.0 4.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF39351.1 - 0.00016 21.3 0.0 0.0014 18.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDF39351.1 - 0.0015 18.3 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF39351.1 - 0.0035 18.1 0.0 0.01 16.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.13 CDF39351.1 - 0.0068 15.9 0.0 0.035 13.6 0.0 1.8 2 0 0 2 2 2 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 CDF39351.1 - 0.011 16.3 0.0 0.03 15.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDF39351.1 - 0.024 14.5 0.0 0.032 14.1 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CDF39351.1 - 0.055 13.5 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_6 PF13480.7 CDF39351.1 - 0.083 13.0 0.2 0.14 12.3 0.2 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Methyltransf_2 PF00891.18 CDF39351.1 - 0.11 11.8 0.0 0.37 10.1 0.0 1.8 2 1 0 2 2 2 0 O-methyltransferase domain Arf PF00025.21 CDF39353.1 - 2.4e-69 232.3 0.0 2.7e-69 232.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDF39353.1 - 1.8e-16 60.4 0.0 2.5e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDF39353.1 - 5e-16 58.7 0.0 5.9e-16 58.5 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CDF39353.1 - 1.1e-12 47.8 0.2 3.2e-09 36.4 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CDF39353.1 - 1.8e-11 43.8 0.0 2.2e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDF39353.1 - 6.3e-08 32.3 0.0 8.7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDF39353.1 - 3.1e-06 27.2 0.0 4.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDF39353.1 - 0.0013 18.3 0.2 0.0048 16.5 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 CDF39353.1 - 0.0066 15.5 0.2 0.02 13.9 0.2 1.7 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 CDF39353.1 - 0.014 14.9 0.2 0.046 13.3 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B CdhD PF03599.16 CDF39353.1 - 0.083 11.6 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit PPR_2 PF13041.6 CDF39354.1 - 3.4e-134 436.9 9.1 2.3e-15 56.5 0.0 14.1 1 1 13 14 14 14 14 PPR repeat family PPR_1 PF12854.7 CDF39354.1 - 2.3e-114 372.7 3.8 1.7e-09 37.2 0.0 14.2 14 0 0 14 14 14 14 PPR repeat PPR PF01535.20 CDF39354.1 - 2.3e-107 344.0 14.0 3e-07 30.2 0.0 14.6 15 0 0 15 15 15 14 PPR repeat PPR_3 PF13812.6 CDF39354.1 - 1.5e-88 290.8 0.0 9.8e-14 51.2 0.0 10.2 6 5 4 10 10 10 8 Pentatricopeptide repeat domain PPR_long PF17177.4 CDF39354.1 - 9e-71 237.6 9.8 1.4e-20 73.6 0.0 4.7 1 1 5 6 6 6 6 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 CDF39354.1 - 1e-06 28.6 0.0 0.04 13.8 0.0 4.9 5 0 0 5 5 5 2 Mitochondrial ATPase expression MRP-S27 PF10037.9 CDF39354.1 - 4e-05 22.7 0.0 0.27 10.0 0.0 4.0 1 1 3 4 4 4 2 Mitochondrial 28S ribosomal protein S27 ECSIT PF06239.11 CDF39354.1 - 0.003 16.7 0.1 29 3.7 0.0 4.7 2 1 1 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway GMP_synt_C PF00958.22 CDF39354.1 - 0.0041 17.1 0.0 9.7 6.3 0.0 3.8 2 2 1 4 4 4 1 GMP synthase C terminal domain TPR_7 PF13176.6 CDF39354.1 - 0.055 13.5 1.6 9.9 6.5 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF39354.1 - 0.27 11.4 9.6 45 4.5 0.0 6.2 7 0 0 7 7 6 0 Tetratricopeptide repeat PA26 PF04636.13 CDF39355.1 - 5 5.9 11.8 0.7 8.8 7.8 1.5 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Ribosomal_L23 PF00276.20 CDF39358.1 - 3.9e-15 56.0 1.9 3.9e-15 56.0 1.9 2.5 2 1 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 CDF39358.1 - 3.6e-14 52.7 5.9 9e-14 51.4 5.9 1.7 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain PRMT5 PF05185.16 CDF39359.1 - 3.2e-65 219.2 0.0 4.8e-65 218.6 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 CDF39359.1 - 1.3e-63 214.6 0.0 1.8e-63 214.2 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 CDF39359.1 - 4.1e-51 173.4 0.9 6.2e-51 172.8 0.9 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 CDF39359.1 - 6.4e-05 23.6 0.0 0.00014 22.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39359.1 - 6.5e-05 22.8 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDF39359.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein LBP_BPI_CETP PF01273.25 CDF39360.1 - 1.3e-08 34.6 0.0 1.6e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Ubie_methyltran PF01209.18 CDF39361.1 - 1.9e-47 161.6 0.0 2.5e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 CDF39361.1 - 1.7e-19 70.3 0.1 4.2e-19 69.0 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF39361.1 - 2.3e-18 66.7 0.1 4.7e-18 65.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39361.1 - 2.5e-14 53.3 0.0 3.5e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF39361.1 - 3.6e-10 40.5 0.0 6.2e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF39361.1 - 2.3e-08 34.1 0.0 3.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF39361.1 - 8.4e-06 25.4 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 CDF39361.1 - 0.00036 20.2 0.0 0.0005 19.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 CDF39361.1 - 0.0016 17.9 0.0 0.0029 17.1 0.0 1.5 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_8 PF05148.15 CDF39361.1 - 0.002 18.0 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase PCMT PF01135.19 CDF39361.1 - 0.0041 16.9 0.1 0.0066 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 CDF39361.1 - 0.074 12.8 0.0 0.93 9.2 0.0 2.1 2 0 0 2 2 2 0 Met-10+ like-protein PrmA PF06325.13 CDF39361.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Peptidase_M20 PF01546.28 CDF39362.1 - 4.9e-33 114.6 0.0 2.1e-32 112.5 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDF39362.1 - 3.6e-08 33.3 0.0 2.7e-07 30.5 0.0 2.1 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CDF39362.1 - 0.002 17.9 0.0 0.0064 16.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 Chloroa_b-bind PF00504.21 CDF39364.1 - 1.5e-42 145.8 0.0 2.1e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Methyltransf_4 PF02390.17 CDF39365.1 - 9.8e-33 113.0 0.0 1.3e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 CDF39365.1 - 0.009 16.7 0.0 0.017 15.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_L39 PF00832.20 CDF39366.1 - 1.3e-19 69.6 13.9 1.4e-19 69.4 13.9 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Nmad3 PF18754.1 CDF39366.1 - 0.0082 15.7 0.4 0.0082 15.7 0.4 1.0 1 0 0 1 1 1 1 Nucleotide modification associated domain 3 Pkinase PF00069.25 CDF39368.1 - 1.7e-42 145.6 0.0 2.4e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39368.1 - 5e-16 58.8 0.0 7.8e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF39368.1 - 1.1e-08 34.8 0.1 1.2e-07 31.4 0.1 2.0 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDF39368.1 - 0.00027 20.4 0.0 0.00047 19.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDF39368.1 - 0.0035 17.0 0.0 0.006 16.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDF39368.1 - 0.0056 16.6 0.0 0.011 15.7 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF39368.1 - 0.073 11.8 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase FIST PF08495.10 CDF39369.1 - 4.9e-18 65.7 0.8 1e-15 58.2 0.1 2.9 3 0 0 3 3 3 2 FIST N domain FIST_C PF10442.9 CDF39369.1 - 3.3e-14 53.0 0.0 5.3e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 FIST C domain TIG PF01833.24 CDF39371.1 - 4.2e-18 65.2 40.5 2.2e-07 30.9 9.8 4.7 5 1 0 5 5 5 3 IPT/TIG domain REJ PF02010.15 CDF39371.1 - 3.5e-07 29.4 5.2 9.3e-06 24.7 0.0 2.8 2 1 0 2 2 2 2 REJ domain Rib PF08428.10 CDF39371.1 - 0.18 11.8 0.1 0.18 11.8 0.1 2.4 2 0 0 2 2 2 0 Rib/alpha-like repeat ribosomal_L24 PF17136.4 CDF39372.1 - 1.5e-15 57.3 0.4 3.3e-15 56.2 0.4 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 CDF39372.1 - 3.5e-07 29.9 1.5 1.8e-06 27.7 1.7 2.1 2 0 0 2 2 2 1 KOW motif IlvN PF07991.12 CDF39373.1 - 9.8e-36 122.8 0.1 1.9e-35 121.9 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CDF39373.1 - 1.6e-34 119.3 0.0 2.5e-26 92.7 0.0 2.3 2 0 0 2 2 2 2 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 CDF39373.1 - 0.0071 15.7 0.1 0.016 14.6 0.1 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lactamase_B_2 PF12706.7 CDF39376.1 - 8.2e-12 45.1 0.1 0.00016 21.2 0.0 2.9 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF39376.1 - 0.0002 21.4 0.0 0.00048 20.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily HAD_2 PF13419.6 CDF39377.1 - 2.7e-25 89.5 0.0 3.2e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF39377.1 - 5.8e-14 52.9 0.1 1.1e-13 52.0 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF39377.1 - 2.1e-09 37.3 0.0 3.6e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NT5C PF06941.12 CDF39377.1 - 0.061 13.2 0.0 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Hydrolase_like PF13242.6 CDF39380.1 - 9.6e-05 22.4 0.0 0.00011 22.2 0.0 1.0 1 0 0 1 1 1 1 HAD-hyrolase-like MMR_HSR1 PF01926.23 CDF39382.1 - 1.3e-17 63.9 0.0 7.6e-17 61.4 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF39382.1 - 4.9e-07 29.4 0.0 1.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDF39382.1 - 0.048 13.6 0.1 0.46 10.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase TIR PF01582.20 CDF39382.1 - 0.12 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 TIR domain Rieske PF00355.26 CDF39383.1 - 9.4e-17 60.7 0.0 1.7e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 CDF39383.1 - 2e-10 40.7 0.0 3.7e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Pheophorbide a oxygenase Rieske_2 PF13806.6 CDF39383.1 - 0.0083 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rab3-GTPase_cat PF13890.6 CDF39386.1 - 5e-38 130.3 4.4 5.1e-25 88.0 2.4 2.3 2 0 0 2 2 2 2 Rab3 GTPase-activating protein catalytic subunit Ion_trans_2 PF07885.16 CDF39389.1 - 5.7e-25 87.1 20.3 3.7e-15 55.7 11.1 2.2 2 0 0 2 2 2 2 Ion channel EF-hand_5 PF13202.6 CDF39389.1 - 6.7e-07 28.5 3.1 0.0072 15.8 0.1 3.3 3 0 0 3 3 3 2 EF hand Ion_trans PF00520.31 CDF39389.1 - 0.00014 21.2 13.4 0.00014 21.1 8.3 2.7 2 1 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.32 CDF39389.1 - 0.00025 20.4 2.4 0.12 12.0 0.1 3.0 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CDF39389.1 - 0.00079 19.2 3.3 0.59 10.2 0.0 3.5 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 CDF39389.1 - 0.00083 19.8 0.9 0.0025 18.2 0.9 1.8 1 0 0 1 1 1 1 EF-hand domain pair Lig_chan PF00060.26 CDF39389.1 - 0.0021 17.9 0.9 0.51 10.2 0.2 2.4 2 0 0 2 2 2 2 Ligand-gated ion channel IRK PF01007.20 CDF39389.1 - 0.053 13.3 2.0 0.2 11.5 0.5 2.1 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain EF-hand_8 PF13833.6 CDF39389.1 - 0.13 12.2 0.1 0.43 10.5 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain pair Nfu_N PF08712.11 CDF39390.1 - 1.4e-30 105.2 0.0 3.2e-30 104.0 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 CDF39390.1 - 9.7e-25 86.5 0.1 1.6e-24 85.9 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain Pkinase PF00069.25 CDF39392.1 - 5.5e-59 199.7 0.0 8.2e-59 199.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39392.1 - 1.1e-28 100.3 0.0 1.7e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 CDF39392.1 - 2.5e-06 27.9 0.0 5e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 CDF39392.1 - 0.00074 18.9 0.0 0.0042 16.4 0.0 1.9 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDF39392.1 - 0.0074 15.1 0.1 0.03 13.1 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CDF39392.1 - 0.014 14.7 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family KH_1 PF00013.29 CDF39393.1 - 1.1e-34 118.0 7.0 1.5e-17 63.2 0.0 3.6 4 0 0 4 4 4 2 KH domain KH_4 PF13083.6 CDF39393.1 - 3.2e-09 36.5 0.1 0.00024 20.9 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 CDF39393.1 - 1.8e-08 34.1 0.2 0.0035 17.1 0.1 2.4 2 0 0 2 2 2 2 KH domain ORC3_N PF07034.11 CDF39393.1 - 0.068 12.3 8.9 0.11 11.6 8.9 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus KH_5 PF13184.6 CDF39393.1 - 0.64 10.2 1.9 11 6.2 0.2 2.7 3 0 0 3 3 3 0 NusA-like KH domain DUF4518 PF15008.6 CDF39393.1 - 6.1 5.9 15.9 9.7 5.3 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) PAT1 PF09770.9 CDF39393.1 - 9.3 4.4 39.7 15 3.7 39.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RT_RNaseH PF17917.1 CDF39394.1 - 1e-30 106.1 0.1 1.2e-29 102.7 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF39394.1 - 1e-19 70.4 0.0 3.2e-19 68.8 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF39394.1 - 1.8e-19 70.0 0.0 4.1e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF39394.1 - 1.1e-11 44.6 0.0 2.1e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF39394.1 - 2.3e-05 24.2 3.5 6.8e-05 22.7 0.6 2.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CDF39394.1 - 2.8e-05 23.8 0.8 0.024 14.2 0.3 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF39394.1 - 0.0012 18.6 0.0 0.0043 16.8 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDF39394.1 - 0.057 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger rve PF00665.26 CDF39395.1 - 4.1e-10 39.9 0.6 0.00098 19.3 0.1 2.6 1 1 1 2 2 2 2 Integrase core domain gag_pre-integrs PF13976.6 CDF39395.1 - 1.4e-05 24.8 0.0 4.5e-05 23.2 0.0 1.9 1 1 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF39395.1 - 0.065 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain CENP-C_mid PF15620.6 CDF39395.1 - 0.08 12.9 1.6 0.16 11.9 1.6 1.4 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region Sulfotransfer_1 PF00685.27 CDF39397.1 - 1e-07 31.7 0.0 1.8e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDF39397.1 - 7.3e-06 26.5 0.2 0.0021 18.4 0.0 2.6 2 1 0 2 2 2 2 Sulfotransferase family Sulfotransfer_4 PF17784.1 CDF39397.1 - 0.00012 22.0 0.0 0.00031 20.6 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase domain TIR_2 PF13676.6 CDF39398.1 - 2e-14 54.2 0.0 4.2e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 TIR domain Roc PF08477.13 CDF39398.1 - 7.8e-08 32.6 0.0 1.9e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 CDF39398.1 - 1.7e-07 31.2 0.0 3.9e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain TIR PF01582.20 CDF39398.1 - 0.00023 21.0 0.0 0.00043 20.1 0.0 1.4 1 0 0 1 1 1 1 TIR domain Ras PF00071.22 CDF39398.1 - 0.022 14.4 0.0 0.078 12.6 0.0 1.9 2 0 0 2 2 2 0 Ras family Gp_dh_N PF00044.24 CDF39398.1 - 0.065 13.6 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Pkinase PF00069.25 CDF39401.1 - 9.3e-59 198.9 0.0 1.5e-58 198.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39401.1 - 2.1e-25 89.5 0.0 3.3e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF39401.1 - 0.0051 16.2 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Queuosine_synth PF02547.15 CDF39404.1 - 3.3e-43 148.0 0.0 3.6e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein SapC PF07277.11 CDF39406.1 - 0.052 13.1 0.0 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 SapC GST_N_3 PF13417.6 CDF39407.1 - 3.8e-14 52.8 0.0 1.1e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF39407.1 - 7.7e-12 45.3 0.0 1.9e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDF39407.1 - 8.5e-08 32.4 0.0 1.8e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDF39407.1 - 6.4e-06 26.1 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CDF39407.1 - 0.00016 22.3 0.1 0.0013 19.5 0.1 2.2 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain Glutaredoxin PF00462.24 CDF39407.1 - 0.0012 19.0 0.1 0.003 17.7 0.1 1.7 1 0 0 1 1 1 1 Glutaredoxin Methyltransf_13 PF08421.11 CDF39407.1 - 0.14 12.5 0.6 9.9 6.5 0.2 2.5 2 0 0 2 2 2 0 Putative zinc binding domain DUF4570 PF15134.6 CDF39412.1 - 0.022 14.8 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) GCV_H PF01597.19 CDF39413.1 - 6.1e-44 148.8 0.0 7e-44 148.6 0.0 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 CDF39413.1 - 0.0055 16.5 0.1 0.023 14.5 0.1 2.0 2 1 1 3 3 3 1 Biotin-requiring enzyme RnfC_N PF13375.6 CDF39413.1 - 0.13 12.2 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Glyco_trans_1_4 PF13692.6 CDF39416.1 - 1.4e-07 32.0 0.0 2e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDF39416.1 - 0.00016 21.2 0.0 0.00027 20.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDF39416.1 - 0.04 14.3 0.0 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferases group 1 Thioredoxin PF00085.20 CDF39417.1 - 0.001 19.0 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AAA PF00004.29 CDF39418.1 - 1.1e-43 148.9 0.0 2.5e-43 147.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDF39418.1 - 9.5e-10 38.3 0.0 1e-08 35.0 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CDF39418.1 - 1.8e-09 37.2 0.0 4.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDF39418.1 - 4.1e-07 30.1 0.1 1.5e-06 28.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDF39418.1 - 6e-07 29.7 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDF39418.1 - 1.3e-06 28.9 0.2 0.00027 21.3 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain DUF815 PF05673.13 CDF39418.1 - 5.4e-06 25.8 0.2 1.3e-05 24.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 CDF39418.1 - 0.0001 22.6 1.1 0.029 14.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 CDF39418.1 - 0.00011 22.5 0.0 0.00021 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF39418.1 - 0.0002 21.9 0.0 0.00076 20.0 0.0 2.0 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 CDF39418.1 - 0.00031 20.5 0.0 0.00069 19.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CDF39418.1 - 0.0033 17.8 0.0 0.0078 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 CDF39418.1 - 0.0047 17.1 0.0 0.015 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CDF39418.1 - 0.0058 16.0 0.1 0.012 15.0 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CDF39418.1 - 0.007 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 CDF39418.1 - 0.0086 15.9 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CDF39418.1 - 0.01 15.9 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDF39418.1 - 0.011 15.5 0.1 0.036 13.8 0.1 1.9 1 1 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 CDF39418.1 - 0.013 15.5 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CDF39418.1 - 0.014 15.4 0.2 0.14 12.1 0.0 2.5 3 0 0 3 3 3 0 NTPase AAA_7 PF12775.7 CDF39418.1 - 0.017 14.6 0.2 0.15 11.6 0.2 2.2 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 CDF39418.1 - 0.019 14.7 0.1 0.21 11.2 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.12 CDF39418.1 - 0.019 14.9 0.2 0.11 12.4 0.1 2.1 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CDF39418.1 - 0.02 14.6 0.4 0.05 13.3 0.4 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDF39418.1 - 0.021 14.6 0.1 0.05 13.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CDF39418.1 - 0.025 13.9 0.7 0.36 10.2 0.0 2.6 3 0 0 3 3 3 0 KaiC DUF3450 PF11932.8 CDF39418.1 - 0.032 13.6 0.1 0.056 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) AAA_25 PF13481.6 CDF39418.1 - 0.042 13.4 1.5 0.11 12.1 0.4 1.9 1 1 1 2 2 2 0 AAA domain TniB PF05621.11 CDF39418.1 - 0.047 13.1 0.0 3.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein HIP1_clath_bdg PF16515.5 CDF39418.1 - 0.079 13.6 0.8 1.9 9.2 0.4 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Parvo_NS1 PF01057.17 CDF39418.1 - 0.098 11.7 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 CDF39418.1 - 0.14 11.3 0.0 0.45 9.7 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain Torsin PF06309.11 CDF39418.1 - 0.17 12.0 0.0 0.54 10.4 0.0 1.8 1 0 0 1 1 1 0 Torsin DUF465 PF04325.13 CDF39418.1 - 1.1 9.3 4.3 2.6 8.2 4.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF465) Proteasome PF00227.26 CDF39419.1 - 7.7e-59 198.4 0.2 1e-58 198.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDF39419.1 - 2.4e-14 52.7 0.2 7e-14 51.2 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature WASH-7_N PF14745.6 CDF39419.1 - 0.018 13.6 0.9 0.029 12.9 0.9 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, N-terminal Lactamase_B PF00753.27 CDF39426.1 - 3e-15 56.8 0.0 4.4e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF39426.1 - 1.8e-07 30.9 0.0 2.5e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Aldolase PF01081.19 CDF39426.1 - 0.054 12.9 0.0 0.088 12.2 0.0 1.3 1 0 0 1 1 1 0 KDPG and KHG aldolase AgrD PF05931.11 CDF39426.1 - 0.13 12.4 0.2 0.23 11.5 0.2 1.4 1 0 0 1 1 1 0 Staphylococcal AgrD protein Aminotran_1_2 PF00155.21 CDF39429.1 - 3.8e-50 171.1 0.0 4.4e-50 170.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 CDF39429.1 - 1.4e-05 24.2 0.0 2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Allinase TruD PF01142.18 CDF39430.1 - 7.9e-65 219.3 0.2 3.5e-59 200.7 0.1 3.2 3 0 0 3 3 3 3 tRNA pseudouridine synthase D (TruD) Cyt-b5 PF00173.28 CDF39432.1 - 3.9e-23 81.4 0.0 5.6e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Myb_DNA-binding PF00249.31 CDF39437.1 - 3.3e-14 52.8 0.5 7.1e-14 51.7 0.1 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF39437.1 - 5.7e-10 39.3 0.0 1.2e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF39437.1 - 0.00068 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Myb DNA-binding like Sigma70_r4_2 PF08281.12 CDF39437.1 - 0.016 14.9 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 GTP_CH_N PF12471.8 CDF39439.1 - 0.034 13.9 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase N terminal YabA PF06156.13 CDF39440.1 - 1.1 9.9 24.9 2 9.1 0.2 4.2 1 1 3 4 4 4 0 Initiation control protein YabA HALZ PF02183.18 CDF39440.1 - 3.8 7.8 11.8 5.3 7.3 0.0 4.7 4 1 0 4 4 4 0 Homeobox associated leucine zipper OKR_DC_1 PF01276.20 CDF39441.1 - 6.9e-61 206.2 0.0 9.1e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 CDF39441.1 - 5.6e-11 42.9 0.0 1.3e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, C-terminal domain Aminotran_5 PF00266.19 CDF39441.1 - 9.5e-08 31.4 0.6 2.1e-07 30.2 0.6 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CDF39441.1 - 1.9e-07 30.6 0.1 2.7e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDF39441.1 - 1.1e-05 24.9 0.6 1.7e-05 24.3 0.6 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SHMT PF00464.19 CDF39441.1 - 0.00012 20.8 0.9 0.0003 19.5 0.7 1.6 1 1 1 2 2 2 1 Serine hydroxymethyltransferase Cys_Met_Meta_PP PF01053.20 CDF39441.1 - 0.00012 20.7 0.0 0.00017 20.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 CDF39441.1 - 0.031 13.0 0.1 0.049 12.4 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain GDC-P PF02347.16 CDF39441.1 - 0.1 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein SurE PF01975.17 CDF39442.1 - 5e-39 134.1 0.2 1.8e-38 132.3 0.1 1.9 2 0 0 2 2 2 1 Survival protein SurE Ribosomal_L11 PF00298.19 CDF39442.1 - 1.1e-27 96.3 0.1 2.4e-27 95.2 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CDF39442.1 - 4.4e-24 84.1 0.3 9.4e-24 83.0 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Glyco_trans_4_4 PF13579.6 CDF39442.1 - 0.033 14.6 1.1 0.033 14.6 1.1 2.9 3 1 0 3 3 3 0 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CDF39442.1 - 0.1 12.6 0.0 0.1 12.6 0.0 2.2 3 0 0 3 3 3 0 Glycosyltransferase Family 4 An_peroxidase PF03098.15 CDF39443.1 - 7.5e-113 377.9 0.0 9.8e-113 377.5 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Peptidase_S24 PF00717.23 CDF39446.1 - 3.1e-09 36.7 0.3 4.6e-09 36.1 0.3 1.3 1 0 0 1 1 1 1 Peptidase S24-like Pkinase PF00069.25 CDF39447.1 - 2.1e-70 237.1 0.0 3.2e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39447.1 - 5.8e-37 127.4 0.0 1e-36 126.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF39447.1 - 0.0011 18.4 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDF39447.1 - 0.013 15.4 0.1 0.05 13.5 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF39447.1 - 0.022 14.4 0.1 0.086 12.4 0.0 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 CDF39447.1 - 0.049 12.6 0.0 0.087 11.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CDF39447.1 - 0.089 12.1 0.1 0.17 11.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HNH_5 PF14279.6 CDF39448.1 - 0.011 15.6 10.3 0.08 12.8 4.8 3.3 3 0 0 3 3 3 0 HNH endonuclease HNH PF01844.23 CDF39448.1 - 0.088 13.0 12.4 0.9 9.8 3.3 4.4 4 1 1 5 5 5 0 HNH endonuclease Helicase_C PF00271.31 CDF39449.1 - 1.1e-20 74.0 0.2 2.4e-20 72.9 0.1 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDF39449.1 - 0.009 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 CDF39449.1 - 0.016 14.4 0.0 0.03 13.5 0.0 1.3 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 NUDIX PF00293.28 CDF39452.1 - 2.4e-11 43.8 0.0 4e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CDF39452.1 - 4.7e-07 30.4 0.0 1.9e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 CDF39452.1 - 7.8e-05 22.2 1.9 0.00014 21.4 1.9 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zf-CCCH_6 PF18585.1 CDF39452.1 - 0.12 12.3 0.2 0.27 11.1 0.2 1.5 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 EMG1 PF03587.14 CDF39453.1 - 3.1e-71 239.0 0.0 4.2e-71 238.6 0.0 1.2 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Trm56 PF01994.16 CDF39453.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 Nop14 PF04147.12 CDF39453.1 - 2.1 6.4 12.9 2.7 6.1 12.9 1.1 1 0 0 1 1 1 0 Nop14-like family tRNA_synt_1c_R2 PF04557.15 CDF39453.1 - 5 8.1 11.7 0.27 12.2 4.8 2.3 1 1 1 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Lactamase_B PF00753.27 CDF39455.1 - 3.4e-20 72.9 0.1 4.4e-20 72.5 0.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF39455.1 - 4.7e-07 29.5 0.0 8.7e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDF39455.1 - 0.0047 16.8 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AAA PF00004.29 CDF39461.1 - 5.2e-43 146.6 0.0 1.1e-42 145.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF39461.1 - 9.4e-11 41.4 0.1 2.1e-10 40.2 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDF39461.1 - 9.6e-08 31.9 1.0 1.9e-07 30.9 1.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 CDF39461.1 - 3.1e-07 30.7 0.0 6.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDF39461.1 - 1.7e-06 28.5 0.1 6.8e-05 23.3 0.1 2.9 1 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CDF39461.1 - 3.4e-06 27.1 0.0 1.5e-05 25.0 0.0 2.1 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDF39461.1 - 8.8e-05 22.8 0.1 0.0086 16.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CDF39461.1 - 0.0001 22.1 0.0 0.00027 20.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CDF39461.1 - 0.00069 19.8 0.0 0.0018 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 CDF39461.1 - 0.0016 17.7 0.0 0.0034 16.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 CDF39461.1 - 0.0022 18.5 0.1 0.014 15.9 0.0 2.4 3 0 0 3 3 1 1 AAA domain IstB_IS21 PF01695.17 CDF39461.1 - 0.0024 17.6 0.0 0.0054 16.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TMF_TATA_bd PF12325.8 CDF39461.1 - 0.0025 18.0 1.9 0.0081 16.4 1.9 1.8 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding OmpH PF03938.14 CDF39461.1 - 0.0036 17.6 0.4 0.0092 16.3 0.4 1.6 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) ERM PF00769.19 CDF39461.1 - 0.0048 16.7 2.8 0.0048 16.7 2.8 1.6 2 0 0 2 2 1 1 Ezrin/radixin/moesin family ATPase PF06745.13 CDF39461.1 - 0.0054 16.1 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 KaiC DASH_Dad2 PF08654.10 CDF39461.1 - 0.0057 17.0 0.4 0.015 15.7 0.4 1.8 1 0 0 1 1 1 1 DASH complex subunit Dad2 Mg_chelatase PF01078.21 CDF39461.1 - 0.0058 16.0 0.2 0.018 14.4 0.1 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF724 PF05266.14 CDF39461.1 - 0.0067 16.3 0.6 0.014 15.2 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF724) RNA_helicase PF00910.22 CDF39461.1 - 0.0095 16.3 0.0 0.023 15.1 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 CDF39461.1 - 0.01 16.1 0.5 0.021 15.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.6 CDF39461.1 - 0.01 15.6 0.4 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain MscS_porin PF12795.7 CDF39461.1 - 0.011 15.3 5.5 0.02 14.5 5.5 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain ATG16 PF08614.11 CDF39461.1 - 0.012 15.9 6.3 0.024 14.9 6.3 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.6 CDF39461.1 - 0.015 15.7 1.3 0.049 14.1 1.3 1.9 1 0 0 1 1 1 0 Snapin/Pallidin AAA_3 PF07726.11 CDF39461.1 - 0.015 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CDF39461.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF5082 PF16888.5 CDF39461.1 - 0.018 15.3 1.0 0.039 14.2 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 CDF39461.1 - 0.019 15.5 4.3 0.046 14.2 4.3 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region PhoH PF02562.16 CDF39461.1 - 0.02 14.4 0.0 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 CDF39461.1 - 0.02 14.6 0.1 0.056 13.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 CDF39461.1 - 0.024 13.3 0.6 0.95 8.0 0.2 2.1 2 0 0 2 2 2 0 AAA domain BBS2_C PF14782.6 CDF39461.1 - 0.025 13.3 0.2 0.039 12.7 0.2 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Spc7 PF08317.11 CDF39461.1 - 0.028 13.3 1.7 0.062 12.2 1.7 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Sigma54_activat PF00158.26 CDF39461.1 - 0.028 14.1 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 CDF39461.1 - 0.03 14.4 0.0 0.065 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF4618 PF15397.6 CDF39461.1 - 0.034 13.6 2.0 0.074 12.5 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) AAA_7 PF12775.7 CDF39461.1 - 0.037 13.5 0.0 0.081 12.4 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region DivIC PF04977.15 CDF39461.1 - 0.039 13.7 3.9 0.086 12.6 3.9 1.6 1 0 0 1 1 1 0 Septum formation initiator AAA_25 PF13481.6 CDF39461.1 - 0.045 13.3 0.1 0.15 11.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain DUF815 PF05673.13 CDF39461.1 - 0.051 12.7 0.0 0.097 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Prominin PF05478.11 CDF39461.1 - 0.052 11.5 0.3 0.092 10.7 0.3 1.3 1 0 0 1 1 1 0 Prominin AAA_19 PF13245.6 CDF39461.1 - 0.054 13.8 0.3 0.39 11.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain CREPT PF16566.5 CDF39461.1 - 0.056 13.6 0.9 0.11 12.6 0.9 1.4 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Parvo_NS1 PF01057.17 CDF39461.1 - 0.056 12.5 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 FapA PF03961.13 CDF39461.1 - 0.077 11.6 0.5 0.15 10.6 0.5 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A GHMP_kinases_C PF08544.13 CDF39461.1 - 0.086 13.2 3.9 15 6.1 0.0 4.4 5 0 0 5 5 4 0 GHMP kinases C terminal Cep57_CLD_2 PF14197.6 CDF39461.1 - 0.092 12.8 7.1 0.066 13.3 4.2 2.3 2 0 0 2 2 1 0 Centrosome localisation domain of PPC89 V_ATPase_I PF01496.19 CDF39461.1 - 0.1 10.5 0.1 0.14 10.0 0.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family USP8_interact PF08941.10 CDF39461.1 - 0.11 12.3 0.4 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 USP8 interacting DUF4407 PF14362.6 CDF39461.1 - 0.12 11.7 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 CDF39461.1 - 0.12 12.4 0.9 0.26 11.3 0.3 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1664) Baculo_E56 PF04639.12 CDF39461.1 - 0.19 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope SlyX PF04102.12 CDF39461.1 - 0.2 12.3 2.8 0.66 10.6 2.8 1.8 1 0 0 1 1 1 0 SlyX ZapB PF06005.12 CDF39461.1 - 0.51 10.8 10.0 0.041 14.3 4.7 1.8 2 0 0 2 2 1 0 Cell division protein ZapB ADIP PF11559.8 CDF39461.1 - 0.59 10.2 7.9 0.13 12.3 3.4 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Sec2p PF06428.11 CDF39461.1 - 0.67 10.0 6.5 1.3 9.0 5.6 1.9 2 0 0 2 2 1 0 GDP/GTP exchange factor Sec2p TolA_bind_tri PF16331.5 CDF39461.1 - 1.2 9.2 10.0 0.71 10.0 6.4 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation UPF0242 PF06785.11 CDF39461.1 - 1.5 8.9 6.3 2.9 8.0 6.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HR1 PF02185.16 CDF39461.1 - 2.4 8.3 10.7 13 6.0 10.7 2.2 1 1 0 1 1 1 0 Hr1 repeat DUF4061 PF13270.6 CDF39461.1 - 2.6 8.4 6.8 0.99 9.8 0.9 2.8 4 0 0 4 4 2 0 Domain of unknown function (DUF4061) FlaC_arch PF05377.11 CDF39461.1 - 3.1 8.3 6.4 2.8 8.4 4.6 2.0 2 0 0 2 2 1 0 Flagella accessory protein C (FlaC) Osmo_CC PF08946.10 CDF39461.1 - 3.5 8.0 5.2 25 5.2 1.8 3.1 2 1 1 3 3 2 0 Osmosensory transporter coiled coil Acetyltransf_1 PF00583.25 CDF39462.1 - 2.1e-09 37.7 0.0 2.6e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF39462.1 - 9.1e-09 35.3 0.0 1.1e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF39462.1 - 6.2e-08 33.0 0.0 1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF39462.1 - 6.3e-07 29.3 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDF39462.1 - 0.0007 19.7 0.1 0.0013 18.8 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4209 PF13910.6 CDF39462.1 - 0.028 14.6 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4209) DUF4260 PF14079.6 CDF39462.1 - 0.043 13.8 0.5 0.11 12.4 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4260) Acetyltransf_15 PF17013.5 CDF39462.1 - 0.061 12.8 0.3 0.087 12.3 0.3 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase GrpE PF01025.19 CDF39463.1 - 1.9e-35 122.0 4.5 2.6e-35 121.5 4.5 1.1 1 0 0 1 1 1 1 GrpE BLYB PF05289.11 CDF39463.1 - 0.022 15.0 0.3 0.039 14.2 0.3 1.5 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein APG17 PF04108.12 CDF39463.1 - 0.022 13.9 2.3 0.03 13.4 2.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF4294 PF14127.6 CDF39463.1 - 0.024 14.5 0.9 0.04 13.8 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) SCAPER_N PF16501.5 CDF39463.1 - 0.076 13.0 0.3 0.13 12.3 0.3 1.3 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum OmpH PF03938.14 CDF39463.1 - 0.72 10.2 5.9 3.2 8.1 5.6 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Cnd1 PF12717.7 CDF39464.1 - 7e-47 159.5 2.5 5.9e-45 153.2 0.4 3.9 3 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDF39464.1 - 9.8e-12 44.2 1.0 3.7e-05 22.5 0.2 4.6 4 1 1 5 5 5 2 Adaptin N terminal region HEAT PF02985.22 CDF39464.1 - 2.5e-06 27.3 10.1 0.11 12.9 0.0 5.6 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 CDF39464.1 - 3.5e-05 24.1 9.4 0.0013 19.1 0.0 5.7 4 2 0 4 4 4 1 HEAT repeats Cnd3 PF12719.7 CDF39464.1 - 6.9e-05 22.2 1.6 0.00022 20.5 0.8 2.3 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Cnd1_N PF12922.7 CDF39464.1 - 0.0027 17.6 0.1 0.016 15.0 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_EZ PF13513.6 CDF39464.1 - 0.092 13.3 10.7 3.6 8.2 0.1 5.6 6 0 0 6 6 6 0 HEAT-like repeat CLASP_N PF12348.8 CDF39464.1 - 0.12 11.9 0.1 1.2 8.6 0.1 2.4 2 0 0 2 2 2 0 CLASP N terminal RIX1 PF08167.12 CDF39464.1 - 0.36 10.5 2.3 13 5.5 0.1 4.1 3 2 1 4 4 4 0 rRNA processing/ribosome biogenesis NAD_binding_1 PF00175.21 CDF39465.1 - 3.5e-26 92.0 0.0 6.3e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.20 CDF39465.1 - 0.00016 21.3 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_6 PF00970.24 CDF39465.1 - 0.00033 20.9 0.0 0.00062 20.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain HEAT_2 PF13646.6 CDF39469.1 - 2.3e-39 133.6 11.0 8.2e-16 58.2 0.2 3.8 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.16 CDF39469.1 - 1e-26 90.8 3.0 0.00045 20.6 0.0 7.3 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.22 CDF39469.1 - 1.8e-12 46.4 0.1 0.011 15.9 0.0 6.0 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 CDF39469.1 - 9.9e-10 38.7 0.2 0.0014 19.1 0.0 4.5 5 0 0 5 5 5 2 HEAT-like repeat Arm PF00514.23 CDF39469.1 - 0.0014 18.6 0.0 0.16 12.0 0.0 2.8 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 CDF39469.1 - 0.063 13.2 0.0 4.5 7.1 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3385) Ank_2 PF12796.7 CDF39470.1 - 4.3e-22 78.5 4.0 3.2e-16 59.7 1.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDF39470.1 - 2.4e-16 59.6 2.7 2.4e-09 37.3 0.1 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDF39470.1 - 2.7e-16 59.7 3.5 5.3e-13 49.2 0.3 3.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDF39470.1 - 9.2e-15 53.3 0.2 1.1e-05 25.4 0.3 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CDF39470.1 - 9.2e-13 48.0 1.7 0.00015 22.0 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat SNO PF01174.19 CDF39471.1 - 2.2e-43 148.3 0.0 2.5e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 CDF39471.1 - 5.4e-10 39.2 0.0 6.6e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 CDF39471.1 - 6.7e-07 29.3 0.0 9.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.17 CDF39471.1 - 1.2e-05 25.1 0.0 1.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 CDF39471.1 - 0.0003 20.7 0.1 0.00055 19.8 0.1 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family NB-ARC PF00931.22 CDF39472.1 - 1e-19 70.8 0.0 2.2e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TIR_2 PF13676.6 CDF39472.1 - 1.7e-15 57.6 0.0 6.4e-15 55.8 0.0 2.0 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF39472.1 - 4.7e-11 42.8 16.4 0.58 10.5 0.1 9.4 4 1 6 11 11 10 6 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF39472.1 - 7.9e-08 32.2 20.4 9e-07 28.7 12.4 3.8 2 1 0 2 2 2 1 PQQ-like domain TIR PF01582.20 CDF39472.1 - 1.4e-07 31.5 0.0 4.3e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 TIR domain PQQ PF01011.21 CDF39472.1 - 6e-07 29.1 5.4 0.27 11.2 0.0 5.6 5 0 0 5 5 5 2 PQQ enzyme repeat WD40 PF00400.32 CDF39472.1 - 0.002 18.9 33.3 0.23 12.4 0.0 9.4 11 0 0 11 11 11 3 WD domain, G-beta repeat eIF2A PF08662.11 CDF39472.1 - 0.014 15.3 1.5 0.092 12.6 0.0 3.0 4 0 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A APAF1_C PF17908.1 CDF39472.1 - 0.02 14.9 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain DPPIV_N PF00930.21 CDF39472.1 - 0.057 12.2 0.8 2.9 6.5 0.1 3.3 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 CDF39472.1 - 0.28 11.2 10.4 23 5.1 0.1 6.6 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 CDF39472.1 - 0.34 10.8 1.7 12 5.8 0.1 3.6 4 0 0 4 4 4 0 Transcription factor IIIC subunit delta N-term Flavin_Reduct PF01613.18 CDF39474.1 - 2.5e-08 34.1 3.7 7.1e-08 32.6 1.8 2.4 2 1 0 2 2 2 1 Flavin reductase like domain DDE_3 PF13358.6 CDF39475.1 - 4.4e-18 65.4 0.0 7.1e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF39475.1 - 3.6e-06 26.7 0.1 7.4e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF39475.1 - 1.5e-05 24.7 3.1 8.8e-05 22.2 0.1 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF39475.1 - 0.0095 15.7 1.5 0.54 10.1 0.0 2.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.12 CDF39475.1 - 0.025 14.5 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 HTH domain Arm PF00514.23 CDF39476.1 - 0.00018 21.5 6.2 14 5.9 0.0 7.0 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat Bromo_TP PF07524.13 CDF39479.1 - 2.6e-05 24.2 0.0 7.7e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated Pox_VLTF3 PF04947.14 CDF39479.1 - 0.22 11.2 0.1 0.39 10.4 0.1 1.3 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like PNRC PF15365.6 CDF39479.1 - 1.9 8.4 10.3 0.1 12.4 4.3 2.2 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator motif CCDC53 PF10152.9 CDF39479.1 - 4.9 7.6 6.7 24 5.3 3.8 2.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Asparaginase_2 PF01112.18 CDF39481.1 - 2e-76 257.0 6.0 3.5e-75 252.9 6.0 1.9 1 1 0 1 1 1 1 Asparaginase RabGAP-TBC PF00566.18 CDF39482.1 - 7.6e-46 156.5 0.1 2.9e-45 154.6 0.1 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Macoilin PF09726.9 CDF39482.1 - 3.6 6.0 8.2 5 5.6 8.2 1.1 1 0 0 1 1 1 0 Macoilin family S36_mt PF10937.8 CDF39482.1 - 9.4 7.9 6.7 5.6 8.6 2.3 2.6 2 1 1 3 3 3 0 Ribosomal protein S36, mitochondrial HEAT_2 PF13646.6 CDF39483.1 - 1.3e-44 150.5 9.3 2.7e-09 37.3 0.1 5.8 2 2 4 6 6 6 6 HEAT repeats HEAT PF02985.22 CDF39483.1 - 6.8e-23 78.8 11.1 0.0078 16.4 0.0 11.1 12 0 0 12 12 12 6 HEAT repeat HEAT_PBS PF03130.16 CDF39483.1 - 2.9e-13 49.1 19.1 0.0046 17.5 0.0 8.9 9 0 0 9 9 9 4 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 CDF39483.1 - 2.7e-10 40.5 21.1 0.00021 21.7 0.0 8.4 6 1 4 10 10 10 4 HEAT-like repeat Arm PF00514.23 CDF39483.1 - 1.1e-07 31.6 1.4 0.39 10.8 0.0 6.3 6 1 1 7 7 7 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CDF39483.1 - 5.2e-05 23.4 0.4 0.53 10.3 0.0 4.3 3 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 ERAP1_C PF11838.8 CDF39483.1 - 0.001 18.7 0.1 0.22 11.1 0.1 2.8 2 1 1 3 3 3 1 ERAP1-like C-terminal domain Adaptin_N PF01602.20 CDF39483.1 - 0.0013 17.4 0.0 0.014 14.0 0.0 2.4 2 2 0 2 2 2 1 Adaptin N terminal region TAF6_C PF07571.13 CDF39483.1 - 0.031 14.6 0.0 1.6 9.1 0.0 3.1 2 1 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain SPG4 PF17325.2 CDF39483.1 - 0.06 14.4 0.9 0.11 13.6 0.9 1.4 1 0 0 1 1 1 0 Stationary phase protein 4 Molybdopterin PF00384.22 CDF39484.1 - 1.2e-48 166.2 0.0 1.6e-47 162.5 0.0 2.0 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 CDF39484.1 - 3.1e-14 53.4 0.1 7.2e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal DUF2009 PF09418.10 CDF39484.1 - 0.098 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) TPP_enzyme_M PF00205.22 CDF39484.1 - 0.15 11.8 0.0 9.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DNA_pol_A PF00476.20 CDF39485.1 - 1.7e-77 261.0 0.0 1.7e-76 257.8 0.0 2.3 1 1 1 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 CDF39485.1 - 2.5e-21 76.2 0.0 3.9e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease GTP_EFTU PF00009.27 CDF39486.1 - 2e-23 83.0 0.0 3.1e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDF39486.1 - 2.2e-06 27.9 0.4 8.8e-06 26.0 0.1 2.2 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDF39486.1 - 0.00012 22.4 1.0 0.00032 21.0 1.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDF39486.1 - 0.0048 16.8 0.2 0.86 9.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CDF39486.1 - 0.0052 16.9 0.2 0.016 15.3 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF39486.1 - 0.045 13.3 0.1 0.93 9.0 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Glt_symporter PF03616.14 CDF39486.1 - 0.047 12.4 0.2 0.069 11.8 0.2 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter PduV-EutP PF10662.9 CDF39486.1 - 0.059 13.1 0.1 17 5.1 0.0 3.3 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ImcF-related_N PF14331.6 CDF39486.1 - 0.089 12.1 0.1 0.19 11.0 0.0 1.5 2 0 0 2 2 2 0 ImcF-related N-terminal domain UPF0014 PF03649.13 CDF39488.1 - 0.002 17.6 0.7 0.0024 17.2 0.7 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) SLATT_1 PF18181.1 CDF39488.1 - 0.098 12.6 0.2 0.17 11.9 0.2 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 FtsJ PF01728.19 CDF39489.1 - 9.5e-51 172.4 0.0 1.2e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase PRKCSH_1 PF13015.6 CDF39489.1 - 0.058 13.1 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein DNMT1-RFD PF12047.8 CDF39490.1 - 2e-07 31.1 0.3 7.3e-07 29.3 0.3 1.9 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain DUF2358 PF10184.9 CDF39491.1 - 2.6e-10 40.6 0.0 3.3e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) RepA_C PF04796.12 CDF39491.1 - 0.03 14.4 0.0 0.069 13.2 0.0 1.5 2 0 0 2 2 2 0 Plasmid encoded RepA protein 2Fe-2S_thioredx PF01257.19 CDF39492.1 - 1.9e-57 193.2 0.0 2.4e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PALP PF00291.25 CDF39493.1 - 2.3e-35 122.4 0.0 3.1e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PP2C PF00481.21 CDF39494.1 - 6.1e-59 199.7 0.0 7.9e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CDF39494.1 - 5.5e-11 42.5 0.0 1.6e-10 41.0 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDF39494.1 - 0.0026 17.7 0.1 0.0087 16.0 0.0 1.8 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Type_III_YscG PF09477.10 CDF39497.1 - 0.047 13.7 0.1 1.3 9.1 0.0 2.2 1 1 1 2 2 2 0 Bacterial type II secretion system chaperone protein (type_III_yscG) zf-RING_5 PF14634.6 CDF39499.1 - 0.026 14.5 5.9 0.042 13.8 5.9 1.5 1 1 0 1 1 1 0 zinc-RING finger domain TFIIIC_delta PF12657.7 CDF39499.1 - 0.42 10.5 1.5 5.2 7.0 0.0 2.0 1 1 1 2 2 2 0 Transcription factor IIIC subunit delta N-term zf-RING_2 PF13639.6 CDF39499.1 - 0.45 10.9 5.9 0.73 10.2 6.0 1.5 1 1 0 1 1 1 0 Ring finger domain Rcd1 PF04078.13 CDF39500.1 - 3.7e-126 419.7 0.1 4.2e-126 419.5 0.1 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like ArfGap PF01412.18 CDF39501.1 - 4.5e-41 139.6 0.0 7.2e-41 138.9 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf UBA PF00627.31 CDF39501.1 - 0.0028 17.5 0.2 0.0047 16.8 0.2 1.4 1 0 0 1 1 1 1 UBA/TS-N domain NDC10_II PF16787.5 CDF39501.1 - 0.075 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 COBRA1 PF06209.13 CDF39504.1 - 0.1 11.4 0.0 0.2 10.5 0.0 1.4 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) EF-hand_7 PF13499.6 CDF39506.1 - 8.1e-13 48.6 0.2 1.6e-12 47.7 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CDF39506.1 - 2.2e-10 39.6 0.5 0.0013 18.5 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDF39506.1 - 3.8e-10 38.6 0.7 0.00011 21.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDF39506.1 - 1.2e-08 34.7 0.4 6.6e-08 32.3 0.2 2.2 1 1 1 2 2 2 1 EF-hand domain pair Na_Ca_ex PF01699.24 CDF39506.1 - 4.4e-07 30.0 15.0 4.4e-07 30.0 15.0 2.8 2 1 0 2 2 2 1 Sodium/calcium exchanger protein EF-hand_5 PF13202.6 CDF39506.1 - 8.3e-06 25.1 0.1 0.0047 16.4 0.0 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 CDF39506.1 - 0.00097 19.4 0.2 0.0017 18.7 0.2 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 CDF39506.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 p25-alpha PIG-P PF08510.12 CDF39506.1 - 0.2 11.6 2.2 0.86 9.5 0.0 2.5 2 0 0 2 2 2 0 PIG-P An_peroxidase PF03098.15 CDF39508.1 - 8.5e-111 371.1 0.0 9.5e-111 370.9 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 CDF39510.1 - 2.6e-109 366.2 0.0 3.1e-109 366.0 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Ribosomal_L2_C PF03947.18 CDF39512.1 - 5.7e-51 172.0 1.7 1.1e-50 171.0 1.7 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CDF39512.1 - 2.6e-24 85.0 4.0 2.7e-24 84.9 0.4 2.8 3 1 1 4 4 4 1 Ribosomal Proteins L2, RNA binding domain Myb_DNA-binding PF00249.31 CDF39513.1 - 3.9e-14 52.6 1.4 6.4e-14 51.9 1.4 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain KHA PF11834.8 CDF39513.1 - 4.5e-08 33.1 0.0 7.6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel Myb_DNA-bind_6 PF13921.6 CDF39513.1 - 9.8e-05 22.5 0.8 0.00016 21.8 0.8 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain SLIDE PF09111.10 CDF39513.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 SLIDE Peptidase_M22 PF00814.25 CDF39514.1 - 1.1e-83 281.1 0.0 1.5e-83 280.6 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CDF39514.1 - 0.0014 18.4 0.0 0.0031 17.3 0.0 1.6 2 0 0 2 2 2 1 Carbamoyltransferase N-terminus Glyco_transf_24 PF18404.1 CDF39515.1 - 4.6e-136 452.5 0.1 7e-136 451.9 0.1 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 UDP-g_GGTase PF06427.11 CDF39515.1 - 3.3e-21 75.5 0.0 6.2e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_14 PF18402.1 CDF39515.1 - 1.6e-10 41.4 4.6 0.00013 22.0 0.0 4.0 4 0 0 4 4 4 2 Thioredoxin-like domain Glyco_transf_8 PF01501.20 CDF39515.1 - 0.00026 20.6 0.0 0.00047 19.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Thioredoxin_12 PF18400.1 CDF39515.1 - 0.013 15.3 0.0 0.037 13.9 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain APH PF01636.23 CDF39518.1 - 4.7e-05 23.4 0.7 0.00011 22.3 0.3 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family CRISPR_Cse2 PF09485.10 CDF39524.1 - 0.029 14.9 2.7 0.87 10.1 0.1 3.2 3 0 0 3 3 3 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Peptidase_S24 PF00717.23 CDF39525.1 - 0.0078 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like zf-U1 PF06220.12 CDF39526.1 - 2e-05 24.3 0.0 3.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 U1 zinc finger Ndc1_Nup PF09531.10 CDF39526.1 - 7.1 5.2 5.3 9.3 4.8 5.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sec63 PF02889.16 CDF39527.1 - 1.2e-128 427.6 0.0 7.2e-72 241.6 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain Helicase_PWI PF18149.1 CDF39527.1 - 6.6e-33 113.2 0.9 1.5e-32 112.0 0.0 2.2 2 0 0 2 2 2 1 N-terminal helicase PWI domain DEAD PF00270.29 CDF39527.1 - 5.1e-29 101.3 0.1 6.4e-27 94.4 0.0 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF39527.1 - 1.7e-11 44.4 0.0 8.5e-11 42.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDF39527.1 - 1.7e-09 38.0 0.0 3.8e-08 33.7 0.0 2.9 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDF39527.1 - 0.00015 22.1 1.1 0.0028 18.0 0.0 3.6 4 0 0 4 4 4 1 AAA domain DnaB_C PF03796.15 CDF39527.1 - 0.16 11.2 0.4 5.4 6.3 0.0 3.0 3 0 0 3 3 3 0 DnaB-like helicase C terminal domain DUF3752 PF12572.8 CDF39527.1 - 3.5 8.1 7.2 0.28 11.7 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3752) Metallophos PF00149.28 CDF39528.1 - 2.5e-14 54.3 0.0 3.2e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.32 CDF39530.1 - 2.7e-36 122.9 20.8 2e-07 31.6 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39530.1 - 1.7e-13 50.7 2.4 0.14 12.5 0.0 6.6 3 1 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF39530.1 - 0.019 13.9 1.0 13 4.7 0.0 3.5 2 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF39530.1 - 0.047 13.0 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 WD40-like domain GDI PF00996.18 CDF39531.1 - 4.2e-189 628.6 0.0 5.3e-189 628.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Rad51 PF08423.11 CDF39532.1 - 2.4e-27 95.8 0.0 3e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 CDF39532.1 - 9.1e-15 54.7 0.1 1.4e-14 54.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 CDF39532.1 - 2e-13 50.4 0.1 6.9e-13 48.7 0.1 1.8 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 CDF39532.1 - 8.1e-10 38.4 0.0 3.9e-09 36.2 0.0 1.9 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 CDF39532.1 - 1e-07 31.9 0.0 2.2e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CDF39532.1 - 4.3e-05 23.0 0.0 0.0079 15.6 0.0 2.1 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 CDF39532.1 - 0.0001 22.6 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF39532.1 - 0.00042 20.7 0.1 0.00062 20.2 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 CDF39532.1 - 0.0011 19.1 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CLP1_P PF16575.5 CDF39532.1 - 0.0078 16.0 0.1 0.023 14.5 0.0 1.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop TrwB_AAD_bind PF10412.9 CDF39532.1 - 0.015 14.2 0.0 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain RNA12 PF10443.9 CDF39532.1 - 0.017 13.9 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 RNA12 protein AAA_11 PF13086.6 CDF39532.1 - 0.029 14.2 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDF39532.1 - 0.031 14.7 0.1 0.046 14.1 0.1 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 CDF39532.1 - 0.034 14.0 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDF39532.1 - 0.035 14.3 0.1 0.051 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDF39532.1 - 0.044 14.3 0.0 0.067 13.7 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 CDF39532.1 - 0.044 14.3 0.0 0.07 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Oleosin PF01277.17 CDF39532.1 - 0.066 13.0 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Oleosin Fer4_NifH PF00142.18 CDF39532.1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Zeta_toxin PF06414.12 CDF39532.1 - 0.22 10.8 0.0 0.45 9.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin SpoIIP PF07454.11 CDF39533.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3192 PF11399.8 CDF39533.1 - 0.27 11.2 0.1 0.3 11.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) LSM PF01423.22 CDF39534.1 - 2.7e-17 62.2 0.3 3.3e-17 61.9 0.3 1.1 1 0 0 1 1 1 1 LSM domain TFIIB PF00382.19 CDF39535.1 - 4.3e-30 103.6 0.3 6.1e-14 51.8 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CDF39535.1 - 1e-12 47.3 2.6 2.6e-12 46.0 2.6 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding BRF1 PF07741.13 CDF39535.1 - 4.4e-12 46.2 12.2 4.4e-12 46.2 12.2 2.5 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 CDF39535.1 - 0.021 14.6 0.1 4 7.2 0.0 2.6 2 0 0 2 2 2 0 Cyclin, N-terminal domain Ribosomal_S27e PF01667.17 CDF39535.1 - 0.029 14.1 0.4 0.064 13.0 0.4 1.5 1 0 0 1 1 1 0 Ribosomal protein S27 ATP-synt PF00231.19 CDF39537.1 - 5e-69 233.1 0.8 5.6e-69 232.9 0.8 1.0 1 0 0 1 1 1 1 ATP synthase Nicastrin PF05450.15 CDF39539.1 - 4.2e-19 68.9 0.1 6.9e-12 45.3 0.0 2.4 2 0 0 2 2 2 2 Nicastrin Ncstrn_small PF18266.1 CDF39539.1 - 2.4e-06 27.7 0.0 4.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Nicastrin small lobe Erp_C PF06780.11 CDF39539.1 - 0.098 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Erp protein C-terminus RPAP1_C PF08620.10 CDF39540.1 - 8.3e-21 73.9 1.9 2.3e-20 72.5 1.9 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 CDF39540.1 - 2.5e-06 27.2 0.1 6e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 RPAP1-like, N-terminal V-ATPase_H_C PF11698.8 CDF39542.1 - 8.1e-37 125.9 0.0 5.5e-36 123.2 0.0 2.2 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 CDF39542.1 - 2.2e-25 89.6 0.0 1.8e-24 86.6 0.0 2.2 2 1 0 2 2 2 1 V-ATPase subunit H Chordopox_G2 PF05796.12 CDF39542.1 - 0.14 11.6 0.1 0.29 10.5 0.1 1.5 1 0 0 1 1 1 0 Chordopoxvirus protein G2 Fumble PF03630.14 CDF39543.1 - 1.6e-91 306.9 0.0 2.1e-91 306.5 0.0 1.2 1 0 0 1 1 1 1 Fumble Hint PF01079.20 CDF39545.1 - 9.7e-21 74.3 0.0 1.5e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Hint module Spond_N PF06468.13 CDF39545.1 - 3.8e-20 72.8 0.0 5.2e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Spondin_N Hom_end_hint PF05203.16 CDF39545.1 - 0.0026 17.8 0.0 0.27 11.1 0.0 2.3 2 0 0 2 2 2 2 Hom_end-associated Hint FKBP_C PF00254.28 CDF39546.1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase TauD PF02668.16 CDF39547.1 - 2.3e-26 93.2 0.1 3.7e-26 92.5 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ribosomal_L5 PF00281.19 CDF39549.1 - 2.8e-19 69.2 0.0 4.8e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.21 CDF39549.1 - 5e-18 65.1 0.0 7.4e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus GNAT_acetyltr_2 PF13718.6 CDF39550.1 - 6.3e-91 303.8 0.0 1.3e-90 302.8 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 CDF39550.1 - 2.7e-57 193.5 0.0 4.6e-57 192.7 0.0 1.4 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 CDF39550.1 - 1.6e-56 191.6 0.0 2.5e-56 191.0 0.0 1.3 1 0 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 CDF39550.1 - 2.2e-31 107.6 0.0 7.6e-31 105.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 CDF39550.1 - 0.0074 16.6 0.0 2.4 8.4 0.0 2.9 2 1 0 2 2 2 1 AAA domain DprA_WH PF17782.1 CDF39550.1 - 0.0085 16.2 0.2 0.023 14.8 0.2 1.7 1 0 0 1 1 1 1 DprA winged helix domain Acetyltransf_1 PF00583.25 CDF39550.1 - 0.01 16.1 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF39550.1 - 0.17 12.3 0.2 1.1 9.7 0.0 2.4 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain GIDA PF01134.22 CDF39552.1 - 5.3e-128 427.4 0.0 9.3e-128 426.6 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDF39552.1 - 5.8e-58 196.5 0.0 9.5e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 CDF39552.1 - 2.5e-07 30.4 2.1 3e-07 30.2 1.2 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF39552.1 - 4.9e-06 26.0 0.3 9.6e-06 25.0 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDF39552.1 - 8.9e-05 21.9 0.3 0.00033 20.0 0.4 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CDF39552.1 - 0.00015 21.0 6.8 0.00037 19.7 5.8 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CDF39552.1 - 0.00046 20.7 0.7 0.0014 19.1 0.7 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF39552.1 - 0.001 17.8 3.1 0.0052 15.5 2.9 1.9 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDF39552.1 - 0.0047 16.2 0.1 0.0081 15.5 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDF39552.1 - 0.041 12.9 1.8 0.09 11.8 1.8 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 CDF39552.1 - 0.045 13.3 5.2 0.029 14.0 2.6 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDF39552.1 - 0.13 12.6 2.8 0.33 11.2 2.8 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SinI PF08671.10 CDF39552.1 - 0.15 11.9 0.1 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Anti-repressor SinI Thi4 PF01946.17 CDF39552.1 - 0.2 10.9 0.4 0.35 10.1 0.4 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 CDF39552.1 - 0.42 9.4 2.2 3.5 6.4 1.8 2.0 2 0 0 2 2 2 0 Tryptophan halogenase NOA36 PF06524.12 CDF39553.1 - 0.087 12.1 1.4 0.092 12.1 1.4 1.0 1 0 0 1 1 1 0 NOA36 protein Myb_DNA-binding PF00249.31 CDF39554.1 - 0.00013 22.1 0.0 0.00023 21.3 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain HAP1_N PF04849.13 CDF39555.1 - 0.00092 18.5 8.3 0.00092 18.5 8.3 3.2 1 1 2 3 3 3 2 HAP1 N-terminal conserved region Spc7 PF08317.11 CDF39555.1 - 0.86 8.4 52.4 0.0081 15.1 5.3 3.9 2 1 2 4 4 4 0 Spc7 kinetochore protein tRNA-synt_2b PF00587.25 CDF39556.1 - 2.7e-20 73.1 0.0 6.8e-20 71.8 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) ProRS-C_1 PF09180.11 CDF39556.1 - 4.8e-17 61.9 0.1 1.2e-16 60.7 0.1 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 CDF39556.1 - 4.6e-13 49.1 0.0 9.2e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 CDF39557.1 - 1.3e-79 267.6 0.1 1.6e-79 267.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDF39557.1 - 9.2e-12 44.8 0.1 1.6e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDF39557.1 - 0.00016 21.3 0.0 0.45 10.0 0.0 2.7 2 1 0 3 3 3 2 tRNA synthetases class II core domain (F) Nucleoporin_N PF08801.11 CDF39557.1 - 0.083 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Nup133 N terminal like tRNA-synt_2d PF01409.20 CDF39558.1 - 5.9e-91 304.3 0.1 7.6e-91 303.9 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 CDF39558.1 - 8.5e-08 31.9 0.0 2.9e-06 26.9 0.0 2.5 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD1 PF18552.1 CDF39558.1 - 1.2e-05 25.0 0.2 3.9e-05 23.3 0.2 1.9 1 0 0 1 1 1 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 CDF39558.1 - 0.00014 22.1 1.2 0.00021 21.5 0.1 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA-synt_2 PF00152.20 CDF39558.1 - 0.0004 19.6 0.1 0.0012 18.0 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) Hydrolase_4 PF12146.8 CDF39559.1 - 4.4e-12 45.8 0.1 1.7e-07 30.8 0.1 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF39559.1 - 3.9e-10 39.8 0.1 8.1e-08 32.2 0.2 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF39559.1 - 7.2e-07 30.0 1.5 7.9e-07 29.9 0.2 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 CDF39559.1 - 1.5e-06 27.1 0.7 0.062 12.0 0.0 3.1 2 1 1 3 3 3 3 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 CDF39559.1 - 0.00045 19.9 0.0 0.047 13.3 0.1 2.5 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 CDF39559.1 - 0.00047 19.7 0.0 0.0016 18.0 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CDF39559.1 - 0.0083 16.0 0.3 0.015 15.1 0.1 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold LIP PF03583.14 CDF39559.1 - 0.033 13.5 0.4 0.39 10.0 0.7 2.1 1 1 1 2 2 2 0 Secretory lipase FSH1 PF03959.13 CDF39559.1 - 0.059 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) 6PGD PF00393.19 CDF39560.1 - 1.4e-120 402.1 0.0 1.6e-120 401.9 0.0 1.0 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CDF39560.1 - 1.8e-28 99.7 0.0 2.9e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DEAD PF00270.29 CDF39563.1 - 5.8e-43 146.7 0.0 9.2e-43 146.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF39563.1 - 6.8e-22 77.9 0.0 3.5e-21 75.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDF39563.1 - 3.9e-06 26.3 0.0 6.2e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CDF39563.1 - 0.00017 21.7 0.0 0.00046 20.2 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDF39563.1 - 0.0018 18.0 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF39563.1 - 0.007 16.7 0.2 0.018 15.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDF39563.1 - 0.23 11.8 0.3 3.4 8.0 0.2 2.7 2 1 0 2 2 2 0 AAA domain RRM_2 PF04059.12 CDF39565.1 - 2.5e-44 149.4 0.2 4.1e-44 148.7 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 CDF39565.1 - 1.8e-25 88.5 0.1 2.7e-14 52.7 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDF39565.1 - 2.4e-09 36.8 0.0 6.5e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF39565.1 - 1.2e-07 31.4 0.0 1.9e-05 24.5 0.0 2.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif BRAP2 PF07576.12 CDF39565.1 - 0.046 14.0 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 BRCA1-associated protein 2 RRM_3 PF08777.11 CDF39565.1 - 0.081 13.0 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 RNA binding motif Smg4_UPF3 PF03467.15 CDF39565.1 - 0.1 12.6 0.0 0.3 11.1 0.1 1.8 2 0 0 2 2 2 0 Smg-4/UPF3 family PSD5 PF07637.11 CDF39569.1 - 0.009 16.3 0.2 0.017 15.5 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1595) zf-C2H2 PF00096.26 CDF39570.1 - 5.5e-15 54.9 34.5 0.0004 20.7 1.4 5.6 6 0 0 6 6 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF39570.1 - 2.7e-11 43.3 32.6 0.00098 19.8 1.1 5.7 6 0 0 6 6 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF39570.1 - 6.9e-10 38.9 26.0 0.0016 18.8 0.1 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_11 PF16622.5 CDF39570.1 - 3.2e-05 23.6 10.9 0.0012 18.6 0.0 4.1 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 CDF39570.1 - 0.00023 21.1 17.6 0.02 14.9 0.4 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger ADK_lid PF05191.14 CDF39570.1 - 0.0063 16.5 4.1 0.5 10.4 0.0 3.4 1 1 2 3 3 3 1 Adenylate kinase, active site lid zf-C2HC_2 PF13913.6 CDF39570.1 - 0.043 13.7 13.1 0.06 13.3 0.2 3.4 4 0 0 4 4 3 0 zinc-finger of a C2HC-type zf-C2H2_3rep PF18868.1 CDF39570.1 - 0.043 14.5 9.3 4.3 8.0 0.0 3.8 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats Ta0938 PF11494.8 CDF39570.1 - 0.098 12.9 0.3 0.17 12.1 0.2 1.5 1 1 0 1 1 1 0 Ta0938 zf-met PF12874.7 CDF39570.1 - 0.12 12.8 19.7 6.6 7.3 0.2 5.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type C1_1 PF00130.22 CDF39570.1 - 0.12 12.3 10.3 0.71 9.8 1.4 3.3 2 2 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_jaz PF12171.8 CDF39570.1 - 0.12 12.7 20.5 0.41 11.0 0.0 4.6 5 0 0 5 5 3 0 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 CDF39570.1 - 0.13 11.9 14.8 4.2 7.0 0.2 4.8 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 CDF39570.1 - 0.16 12.1 14.2 27 5.0 4.8 4.1 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_8 PF15909.5 CDF39570.1 - 0.2 12.0 0.2 0.2 12.0 0.2 3.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon XPA_N PF01286.18 CDF39570.1 - 0.2 11.7 0.4 0.2 11.7 0.4 4.1 4 0 0 4 4 4 0 XPA protein N-terminal zinc_ribbon_15 PF17032.5 CDF39570.1 - 0.3 11.9 12.0 0.77 10.6 1.8 2.9 1 1 3 4 4 4 0 zinc-ribbon family zf-C2H2_2 PF12756.7 CDF39570.1 - 0.81 10.1 19.2 2.1 8.7 4.0 3.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DZR PF12773.7 CDF39570.1 - 0.95 9.5 8.8 1.8e+02 2.2 8.8 2.7 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 CDF39570.1 - 1.8 8.5 16.0 4.1 7.4 0.8 4.1 4 0 0 4 4 4 0 zinc-ribbon domain zf-trcl PF13451.6 CDF39570.1 - 1.9 8.5 15.2 0.14 12.1 2.4 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-C2HE PF16278.5 CDF39570.1 - 2.9 8.4 19.3 3.2 8.3 0.3 4.0 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Mrx7 PF10906.8 CDF39570.1 - 6 7.2 7.0 17 5.7 1.3 3.2 2 1 0 3 3 3 0 MIOREX complex component 7 zinc-ribbons_6 PF07191.12 CDF39570.1 - 7.2 6.7 9.9 2.6e+03 -1.5 9.9 2.9 1 1 0 1 1 1 0 zinc-ribbons EF_assoc_2 PF08356.12 CDF39572.1 - 1.1e-24 86.2 0.0 3.6e-23 81.4 0.0 2.3 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 CDF39572.1 - 2.3e-23 82.6 0.0 8e-20 71.1 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CDF39572.1 - 2.1e-14 53.8 0.0 8.4e-14 51.8 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF_assoc_1 PF08355.12 CDF39572.1 - 1.1e-09 37.8 0.0 2.9e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF-hand_6 PF13405.6 CDF39572.1 - 2.9e-09 36.1 3.9 0.00024 20.8 0.1 3.0 3 0 0 3 3 2 2 EF-hand domain GTP_EFTU PF00009.27 CDF39572.1 - 5.6e-09 35.8 0.2 3.5e-06 26.7 0.0 3.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain EF-hand_1 PF00036.32 CDF39572.1 - 4.3e-08 32.1 4.8 0.0028 17.1 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CDF39572.1 - 5.9e-08 33.0 0.3 0.0058 17.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair MMR_HSR1 PF01926.23 CDF39572.1 - 2.1e-07 31.0 0.1 7.4e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_5 PF13202.6 CDF39572.1 - 1.6e-05 24.2 4.6 0.0068 15.9 0.1 3.5 3 0 0 3 3 3 2 EF hand SRPRB PF09439.10 CDF39572.1 - 2.6e-05 23.7 0.0 4.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 CDF39572.1 - 6e-05 22.6 0.0 0.00011 21.7 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDF39572.1 - 7.2e-05 22.2 0.1 0.0037 16.7 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 CDF39572.1 - 0.0021 18.2 1.2 0.89 9.6 0.1 2.7 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 CDF39572.1 - 0.013 15.0 0.2 0.036 13.6 0.1 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B EF-hand_10 PF14788.6 CDF39572.1 - 0.014 15.2 1.7 0.17 11.8 0.2 2.4 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 CDF39572.1 - 0.016 15.1 2.4 2.8 7.9 0.2 3.2 4 0 0 4 4 4 0 EF-hand domain pair AIG1 PF04548.16 CDF39572.1 - 0.029 13.7 0.2 0.05 12.9 0.2 1.4 1 0 0 1 1 1 0 AIG1 family TniB PF05621.11 CDF39572.1 - 0.13 11.6 0.0 1 8.7 0.0 2.4 3 0 0 3 3 3 0 Bacterial TniB protein Symplekin_C PF12295.8 CDF39572.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Symplekin tight junction protein C terminal PQ-loop PF04193.14 CDF39573.1 - 0.00029 20.5 1.2 0.00082 19.1 1.2 1.8 1 0 0 1 1 1 1 PQ loop repeat DUF3977 PF13122.6 CDF39573.1 - 0.094 12.9 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3977) Ycf4 PF02392.16 CDF39573.1 - 0.97 9.0 4.8 1.4 8.4 4.8 1.3 1 0 0 1 1 1 0 Ycf4 TFIIB PF00382.19 CDF39574.1 - 3.9e-24 84.5 0.7 2.5e-11 43.4 0.1 3.2 3 0 0 3 3 3 3 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CDF39574.1 - 2.2e-14 52.7 1.4 3.7e-14 52.0 1.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4_2 PF08281.12 CDF39574.1 - 0.00098 18.8 0.1 0.27 10.9 0.1 2.6 2 0 0 2 2 2 2 Sigma-70, region 4 OpuAC PF04069.12 CDF39574.1 - 0.018 14.6 0.2 0.028 14.0 0.2 1.2 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system Ribosomal_S27e PF01667.17 CDF39574.1 - 0.037 13.8 0.1 0.067 12.9 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 RB_B PF01857.20 CDF39574.1 - 0.047 13.7 0.2 0.37 10.8 0.1 2.3 2 1 0 2 2 2 0 Retinoblastoma-associated protein B domain Cyclin_N PF00134.23 CDF39574.1 - 0.052 13.3 0.3 0.29 10.9 0.0 2.1 2 1 0 2 2 2 0 Cyclin, N-terminal domain Pox_TAA1 PF03295.14 CDF39574.1 - 0.079 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Poxvirus trans-activator protein A1 C-terminal zf-RING_9 PF13901.6 CDF39574.1 - 0.13 12.2 0.4 6.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon IBR PF01485.21 CDF39575.1 - 1.7e-07 31.3 7.6 1.7e-07 31.3 7.6 2.8 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain zf-RING_14 PF17978.1 CDF39575.1 - 0.016 15.6 0.7 0.038 14.4 0.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 CDF39575.1 - 0.032 14.6 6.1 0.032 14.6 6.1 2.6 2 0 0 2 2 2 0 Ring finger domain zf-UDP PF14569.6 CDF39575.1 - 0.17 12.0 5.5 4.5 7.5 0.2 2.6 2 0 0 2 2 2 0 Zinc-binding RING-finger Ribosomal_L19e PF01280.20 CDF39576.1 - 2.4e-62 209.2 7.5 2.4e-62 209.2 7.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L19e GLTSCR1 PF15249.6 CDF39577.1 - 8.2e-05 23.0 0.0 8.2e-05 23.0 0.0 2.1 3 0 0 3 3 3 1 Conserved region of unknown function on GLTSCR protein Transformer PF06495.11 CDF39577.1 - 0.0072 16.4 1.2 0.0072 16.4 1.2 2.4 3 0 0 3 3 3 1 Fruit fly transformer protein GlutR_N PF05201.15 CDF39578.1 - 3e-42 143.8 0.5 4.8e-42 143.2 0.5 1.4 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 CDF39578.1 - 8.4e-40 136.0 0.3 2e-39 134.8 0.3 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 CDF39578.1 - 9.6e-24 83.7 0.5 2.7e-23 82.2 0.5 1.8 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain OCD_Mu_crystall PF02423.15 CDF39578.1 - 4.5e-09 35.7 0.0 7.6e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 CDF39578.1 - 2.5e-07 31.2 2.8 5.2e-07 30.2 0.0 2.7 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CDF39578.1 - 0.002 18.3 0.0 0.0044 17.2 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Gp_dh_N PF00044.24 CDF39578.1 - 0.0058 17.0 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CDF39578.1 - 0.014 15.8 0.0 0.043 14.3 0.0 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CDF39578.1 - 0.051 13.8 0.0 0.14 12.4 0.0 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 CDF39578.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CDF39578.1 - 0.079 13.2 0.0 0.28 11.5 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain AlaDh_PNT_C PF01262.21 CDF39578.1 - 0.11 11.8 0.3 0.18 11.1 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF448 PF04296.13 CDF39580.1 - 1.5e-12 47.2 0.1 2.9e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF448) NOA36 PF06524.12 CDF39581.1 - 0.072 12.4 2.0 0.14 11.5 2.0 1.5 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 CDF39581.1 - 1.1 9.0 20.8 0.054 13.3 6.2 2.7 2 1 1 3 3 3 0 Pox virus Ag35 surface protein Myb_DNA-binding PF00249.31 CDF39582.1 - 9.1e-10 38.6 0.3 1.7e-09 37.7 0.3 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF39582.1 - 0.0087 16.3 0.8 0.02 15.2 0.8 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain CDP-OH_P_transf PF01066.21 CDF39583.1 - 1.1e-09 38.9 0.4 1.1e-09 38.9 0.4 2.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase NopRA1 PF16201.5 CDF39585.1 - 1.6e-19 70.3 0.0 5.6e-17 62.0 0.0 3.2 2 0 0 2 2 2 2 Nucleolar pre-ribosomal-associated protein 1 Trypsin PF00089.26 CDF39590.1 - 1.1e-43 149.7 0.0 1.4e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin Band_7 PF01145.25 CDF39591.1 - 3.6e-25 89.0 3.1 5.8e-25 88.3 3.1 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family Peptidase_S66 PF02016.15 CDF39591.1 - 0.13 12.4 0.2 0.37 10.9 0.2 1.7 1 1 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Helicase_C PF00271.31 CDF39592.1 - 7.5e-22 77.8 0.1 1.2e-21 77.1 0.1 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cation_ATPase PF13246.6 CDF39593.1 - 1.1e-10 41.5 0.0 2.7e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDF39593.1 - 3.8e-07 30.6 0.2 2.6e-06 27.9 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDF39593.1 - 1.1e-06 28.3 0.0 2.7e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 E1-E2 ATPase LRR_9 PF14580.6 CDF39594.1 - 1.4e-25 89.8 0.3 1.6e-25 89.6 0.3 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 CDF39594.1 - 2.8e-12 46.2 0.5 4.4e-07 29.6 0.1 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDF39594.1 - 6.9e-09 35.9 1.6 1.8e-05 25.0 0.0 3.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDF39594.1 - 0.0021 18.0 0.5 3 8.1 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 CDF39594.1 - 0.029 14.9 0.1 35 5.5 0.0 3.6 4 1 0 4 4 4 0 Leucine Rich Repeat G-patch PF01585.23 CDF39597.1 - 1.6e-15 56.7 2.9 1.6e-15 56.7 2.9 1.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CDF39597.1 - 4.4e-09 36.3 3.2 4.4e-09 36.3 3.2 2.7 3 0 0 3 3 3 1 G-patch domain R3H PF01424.22 CDF39597.1 - 1e-07 31.8 0.0 2.6e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 R3H domain Herpes_UL56 PF04534.12 CDF39597.1 - 0.047 13.2 5.3 1 8.8 0.2 2.5 2 0 0 2 2 2 0 Herpesvirus UL56 protein Conotoxin PF02950.17 CDF39597.1 - 1.2 10.2 2.9 43 5.2 1.6 2.7 2 0 0 2 2 2 0 Conotoxin PBP1_TM PF14812.6 CDF39597.1 - 4.9 7.6 11.1 1.4 9.3 1.2 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TBCC PF07986.12 CDF39598.1 - 2.8e-30 104.5 0.0 4.1e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 CDF39598.1 - 6.6e-05 23.3 0.0 0.0001 22.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain eIF-3c_N PF05470.12 CDF39601.1 - 1.8e-135 452.6 10.3 3.9e-87 293.0 0.1 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CDF39601.1 - 7.1e-11 42.6 0.0 2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 PCI domain RRP7 PF12923.7 CDF39601.1 - 1.2 9.3 3.8 1 9.5 0.3 2.6 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Branch PF02485.21 CDF39602.1 - 0.00027 20.5 0.1 0.0011 18.6 0.1 1.9 1 1 0 1 1 1 1 Core-2/I-Branching enzyme Pkinase PF00069.25 CDF39603.1 - 2.2e-72 243.6 0.0 3.4e-72 243.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39603.1 - 3.8e-40 137.8 0.0 5.8e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF39603.1 - 7.3e-05 22.2 0.0 0.00014 21.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDF39603.1 - 0.013 15.1 0.1 0.028 14.0 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CDF39603.1 - 0.065 12.6 0.2 0.15 11.4 0.2 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF39603.1 - 0.1 12.5 0.0 1.4 8.8 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF563 PF04577.14 CDF39605.1 - 1e-15 58.5 0.2 2.8e-15 57.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF563) DUF1235 PF06822.12 CDF39608.1 - 0.053 12.8 0.0 0.053 12.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) zf-B_box PF00643.24 CDF39610.1 - 1.6e-05 24.9 6.5 0.039 14.1 0.2 2.3 2 0 0 2 2 2 2 B-box zinc finger Atrophin-1 PF03154.15 CDF39612.1 - 0.57 8.4 9.8 0.75 8.0 9.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family EIF4E-T PF10477.9 CDF39612.1 - 7.7 5.2 13.5 9.6 4.9 13.5 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E zf-4CXXC_R1 PF10497.9 CDF39613.1 - 0.005 17.0 14.9 0.0095 16.1 14.9 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Periviscerokin PF08259.11 CDF39613.1 - 0.093 13.0 0.3 0.46 10.9 0.3 2.3 1 0 0 1 1 1 0 Periviscerokinin family GidB PF02527.15 CDF39616.1 - 3.3e-22 78.7 0.0 5.5e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G YjeF_N PF03853.15 CDF39619.1 - 3.9e-24 85.4 0.0 6.3e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus APH PF01636.23 CDF39621.1 - 7.6e-09 35.8 0.8 7.6e-09 35.8 0.8 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF39621.1 - 0.02 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 CDF39622.1 - 1e-08 35.4 0.2 2e-08 34.5 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF39622.1 - 0.043 13.1 0.0 0.2 10.9 0.0 1.9 1 1 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 CDF39622.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase PIF1 PF05970.14 CDF39624.1 - 1.6e-92 310.5 0.0 2.4e-92 309.9 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF39624.1 - 2.5e-59 200.7 0.0 5.3e-59 199.6 0.0 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF39624.1 - 3.4e-06 26.9 0.0 6.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF39624.1 - 0.073 11.0 0.0 0.11 10.3 0.0 1.2 1 0 0 1 1 1 0 Helicase An_peroxidase PF03098.15 CDF39625.1 - 1.9e-110 370.0 0.0 2.2e-110 369.8 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Topoisom_I_N PF02919.15 CDF39626.1 - 6e-50 169.7 0.0 1.1e-49 168.8 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment An_peroxidase PF03098.15 CDF39627.1 - 1.4e-113 380.3 0.0 1.6e-113 380.1 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase RT_RNaseH_2 PF17919.1 CDF39628.1 - 5.3e-33 113.0 0.0 7.5e-33 112.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF39628.1 - 6.9e-33 113.1 0.0 1.6e-32 111.9 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF39628.1 - 0.045 13.3 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Pdase_C33_assoc PF14756.6 CDF39633.1 - 0.022 14.7 0.3 0.028 14.4 0.3 1.2 1 0 0 1 1 1 0 Peptidase_C33-associated domain DUF1657 PF07870.11 CDF39633.1 - 0.023 14.6 0.5 0.046 13.6 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) Spc24 PF08286.11 CDF39633.1 - 4.3 7.6 7.7 1.3 9.3 4.1 1.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 A_deaminase PF00962.22 CDF39634.1 - 1.2e-106 356.8 0.0 1.8e-106 356.2 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase TraC_F_IV PF11130.8 CDF39634.1 - 0.045 13.3 0.5 0.23 11.1 0.3 2.1 2 0 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer Mon2_C PF16206.5 CDF39635.1 - 9.3e-35 120.0 3.6 1.7e-26 92.6 2.0 3.3 2 1 0 2 2 2 2 C-terminal region of Mon2 protein DCB PF16213.5 CDF39635.1 - 8.1e-19 68.0 3.2 5.1e-18 65.4 0.7 3.0 2 1 1 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 CDF39635.1 - 1.5e-13 51.0 1.2 2.9e-13 50.0 0.0 2.2 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal HTH_Tnp_Tc3_1 PF11427.8 CDF39636.1 - 1.9e-08 34.0 0.0 3.4e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF39636.1 - 6.5e-06 25.8 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF39636.1 - 0.00082 19.1 0.5 0.0031 17.3 0.1 2.2 2 0 0 2 2 2 1 Homeodomain-like domain DUF742 PF05331.11 CDF39636.1 - 0.042 13.6 0.0 1.2 9.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF742) HTH_Tnp_Tc3_2 PF01498.18 CDF39636.1 - 0.13 12.5 2.1 0.2 11.9 0.2 2.1 2 1 0 2 2 2 0 Transposase DDE_3 PF13358.6 CDF39637.1 - 2.8e-08 33.6 0.1 8.1e-08 32.1 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF2695 PF10905.8 CDF39637.1 - 0.13 12.5 0.2 11 6.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2695) Nucleotid_trans PF03407.16 CDF39638.1 - 4.7e-30 105.1 0.0 7.4e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Nucleotid_trans PF03407.16 CDF39639.1 - 4.3e-31 108.5 0.0 6.3e-31 108.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase MoaE PF02391.17 CDF39641.1 - 3.7e-37 127.0 0.1 4.5e-37 126.8 0.1 1.1 1 0 0 1 1 1 1 MoaE protein TOBE_3 PF12857.7 CDF39642.1 - 0.094 12.6 0.1 0.47 10.4 0.1 1.9 2 0 0 2 2 2 0 TOBE-like domain Med4 PF10018.9 CDF39643.1 - 0.025 14.3 0.4 0.033 13.9 0.4 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4889 PF16230.5 CDF39643.1 - 0.083 13.1 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) PseudoU_synth_2 PF00849.22 CDF39644.1 - 9e-25 87.6 0.0 1.4e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Glycos_transf_2 PF00535.26 CDF39645.1 - 0.0039 17.0 0.0 0.054 13.3 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CDF39645.1 - 0.1 12.0 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 21 ORMDL PF04061.14 CDF39646.1 - 1.5e-32 112.3 4.5 1.7e-32 112.1 4.5 1.0 1 0 0 1 1 1 1 ORMDL family ABC_tran PF00005.27 CDF39648.1 - 2.2e-31 109.2 0.0 4.1e-31 108.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDF39648.1 - 2.7e-23 83.0 1.7 3.9e-23 82.5 1.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDF39648.1 - 2e-07 30.7 0.0 7.6e-07 28.8 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF39648.1 - 0.0055 16.4 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDF39648.1 - 0.0081 16.4 1.4 0.088 13.1 0.5 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDF39648.1 - 0.0082 16.5 0.0 0.028 14.8 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 CDF39648.1 - 0.0095 15.2 0.1 0.19 11.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.17 CDF39648.1 - 0.034 13.9 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein SbcCD_C PF13558.6 CDF39648.1 - 0.037 14.3 0.1 0.16 12.2 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 CDF39648.1 - 0.062 12.9 0.1 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain L51_S25_CI-B8 PF05047.16 CDF39649.1 - 1.5e-11 44.0 0.0 2e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF3143 PF11341.8 CDF39649.1 - 0.015 15.7 0.0 0.021 15.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3143) LSM PF01423.22 CDF39650.1 - 1.5e-16 59.9 0.0 2e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDF39650.1 - 0.089 12.5 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Hfq protein Fasciclin PF02469.22 CDF39651.1 - 1.4e-26 93.2 0.0 2.2e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain STN PF07660.14 CDF39651.1 - 0.037 13.8 0.0 0.71 9.7 0.0 2.5 1 1 1 2 2 2 0 Secretin and TonB N terminus short domain PseudoU_synth_1 PF01416.20 CDF39652.1 - 1.3e-12 48.2 0.0 1.6e-09 38.2 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase PIF1 PF05970.14 CDF39653.1 - 3e-93 312.9 0.0 4.4e-93 312.4 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF39653.1 - 6.1e-60 202.7 0.0 1.6e-59 201.3 0.0 1.8 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF39653.1 - 3.5e-06 26.9 0.0 6.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF39653.1 - 0.042 11.8 0.0 0.068 11.1 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF39653.1 - 0.054 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Glyco_tranf_2_3 PF13641.6 CDF39654.1 - 1.2e-21 77.7 0.0 1.8e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDF39654.1 - 1.9e-21 76.6 0.1 5.2e-21 75.2 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 CDF39654.1 - 1.5e-13 51.1 1.0 1.5e-13 51.1 1.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 CDF39654.1 - 1.8e-11 43.3 1.3 3.9e-07 29.0 0.5 3.1 2 1 1 3 3 3 3 Cellulose synthase Glyco_transf_21 PF13506.6 CDF39654.1 - 9.1e-08 31.8 0.1 0.003 17.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 21 TFIIE-A_C PF11521.8 CDF39654.1 - 2.2 8.7 8.1 0.11 12.8 0.5 2.2 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha DUF3340 PF11818.8 CDF39655.1 - 0.019 15.1 2.4 0.035 14.3 2.4 1.4 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) ETC_C1_NDUFA5 PF04716.14 CDF39656.1 - 2e-23 82.0 0.1 3e-23 81.4 0.1 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region PAC3 PF10178.9 CDF39657.1 - 3.2e-22 78.5 0.3 4e-22 78.1 0.3 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 DUF4203 PF13886.6 CDF39660.1 - 0.032 13.9 33.2 0.12 12.0 32.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4203) GerA PF03323.13 CDF39660.1 - 1.7 7.0 7.4 2.3 6.6 7.4 1.3 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein Anoctamin PF04547.12 CDF39660.1 - 7 5.4 6.1 2.9 6.6 0.0 2.2 2 1 0 2 2 2 0 Calcium-activated chloride channel Ubiquitin_2 PF14560.6 CDF39661.1 - 2.1e-17 63.4 0.0 3.1e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain CAP_GLY PF01302.25 CDF39661.1 - 8.1e-17 61.0 1.7 1.2e-16 60.4 1.7 1.3 1 0 0 1 1 1 1 CAP-Gly domain ubiquitin PF00240.23 CDF39661.1 - 0.0095 15.7 0.0 0.081 12.7 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin family Corona_NSP4_C PF16348.5 CDF39661.1 - 0.015 16.1 0.0 0.034 14.9 0.0 1.6 1 0 0 1 1 1 0 Coronavirus nonstructural protein 4 C-terminus SH3_9 PF14604.6 CDF39661.1 - 0.19 11.6 0.9 1.7 8.6 0.2 2.4 2 0 0 2 2 2 0 Variant SH3 domain RT_RNaseH PF17917.1 CDF39662.1 - 3.8e-22 78.5 0.2 1.1e-21 77.0 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF39662.1 - 3.4e-20 72.4 0.0 9.1e-20 71.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF39662.1 - 9.2e-16 57.7 0.5 2.7e-15 56.2 0.1 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 CDF39662.1 - 1.8e-10 40.7 0.0 3.9e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 CDF39662.1 - 0.0025 18.0 0.0 0.0052 17.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 CDF39662.1 - 0.0078 15.7 0.0 0.16 11.4 0.0 2.2 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF39662.1 - 0.03 14.1 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain FGAR-AT_linker PF18072.1 CDF39662.1 - 0.14 12.7 0.1 0.83 10.2 0.1 2.2 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain Pribosyltran_N PF13793.6 CDF39663.1 - 4.9e-47 158.7 0.0 2.7e-46 156.3 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDF39663.1 - 8.3e-25 87.9 3.6 1.7e-24 86.8 0.6 2.3 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDF39663.1 - 1.8e-22 79.6 2.6 5.6e-19 68.2 0.4 2.8 2 1 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 CDF39663.1 - 2.1e-05 24.1 0.2 4e-05 23.2 0.2 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CbiG_N PF11760.8 CDF39663.1 - 0.017 15.1 0.9 0.39 10.7 0.1 2.8 2 0 0 2 2 2 0 Cobalamin synthesis G N-terminal Retrotran_gag_2 PF14223.6 CDF39664.1 - 3.3e-16 59.2 0.5 9.5e-15 54.5 0.1 2.3 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF39664.1 - 1.2e-15 57.8 0.3 4.1e-11 43.1 0.0 2.9 2 1 1 3 3 3 2 Integrase core domain gag_pre-integrs PF13976.6 CDF39664.1 - 1.4e-08 34.4 0.1 1.8e-07 30.9 0.0 2.6 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF39664.1 - 0.00058 19.6 0.0 0.0017 18.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_6 PF15288.6 CDF39664.1 - 0.047 13.5 1.5 0.14 12.0 1.5 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF39664.1 - 0.36 11.0 3.9 1.1 9.5 3.9 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF39664.1 - 0.46 10.3 2.2 1.7 8.4 2.2 2.0 1 0 0 1 1 1 0 Zinc knuckle WD40 PF00400.32 CDF39665.1 - 2.9e-55 183.0 29.2 5.9e-09 36.4 0.1 8.6 8 0 0 8 8 8 8 WD domain, G-beta repeat NB-ARC PF00931.22 CDF39665.1 - 9.3e-15 54.5 0.0 1.8e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF39665.1 - 5.4e-14 52.3 10.3 0.0077 16.5 0.1 7.7 2 1 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF39665.1 - 8e-06 24.8 14.3 6.6 5.2 0.0 7.8 3 3 4 8 8 8 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF39665.1 - 2e-05 23.7 4.5 6.5 5.6 0.0 6.1 1 1 6 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 CDF39665.1 - 0.00044 20.5 0.0 0.0017 18.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain PQQ_3 PF13570.6 CDF39665.1 - 0.025 15.1 25.7 0.31 11.6 0.4 7.0 1 1 6 7 7 7 0 PQQ-like domain Cytochrom_D1 PF02239.16 CDF39665.1 - 0.033 12.7 21.0 0.07 11.6 1.1 3.3 2 1 1 3 3 3 0 Cytochrome D1 heme domain APAF1_C PF17908.1 CDF39665.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain Frtz PF11768.8 CDF39665.1 - 0.15 10.3 0.0 16 3.7 0.0 3.6 2 2 4 6 6 6 0 WD repeat-containing and planar cell polarity effector protein Fritz Pkinase PF00069.25 CDF39666.1 - 6.2e-63 212.6 0.0 7.6e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39666.1 - 4.6e-42 144.1 0.0 6.8e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF39666.1 - 1.1e-09 37.6 0.0 2.6e-09 36.4 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CDF39666.1 - 0.0029 17.0 0.0 0.023 14.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Myb_DNA-binding PF00249.31 CDF39669.1 - 1.5e-11 44.3 0.3 3.1e-11 43.3 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF39669.1 - 0.052 13.8 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF3067 PF11267.8 CDF39670.1 - 2.8e-26 92.0 0.0 4.3e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3067) PduV-EutP PF10662.9 CDF39670.1 - 0.016 15.0 0.1 0.027 14.2 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF3484 PF11983.8 CDF39670.1 - 0.024 15.7 0.1 0.056 14.6 0.1 1.7 1 0 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch EMP24_GP25L PF01105.24 CDF39671.1 - 2.5e-37 128.6 1.1 2.9e-37 128.4 1.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RTBV_P46 PF06216.11 CDF39672.1 - 0.0021 17.0 0.8 0.0027 16.7 0.8 1.1 1 0 0 1 1 1 1 Rice tungro bacilliform virus P46 protein Spc24 PF08286.11 CDF39672.1 - 0.024 14.9 1.9 0.024 14.9 1.9 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 CDF39672.1 - 0.098 13.2 16.4 0.053 14.0 13.7 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region FapA PF03961.13 CDF39672.1 - 0.18 10.4 5.8 0.21 10.2 5.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Dam1 PF08653.10 CDF39672.1 - 0.2 11.5 1.3 6.9 6.6 0.1 2.9 3 0 0 3 3 3 0 DASH complex subunit Dam1 CorA PF01544.18 CDF39672.1 - 0.22 10.8 7.5 0.31 10.3 7.5 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Jnk-SapK_ap_N PF09744.9 CDF39672.1 - 0.26 11.5 17.9 0.13 12.5 15.1 1.8 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Mannitol_dh PF01232.23 CDF39672.1 - 0.29 11.3 1.4 0.72 10.0 1.3 1.7 1 1 0 1 1 1 0 Mannitol dehydrogenase Rossmann domain DASH_Dad1 PF08649.10 CDF39672.1 - 0.31 11.2 2.4 32 4.8 0.2 3.5 3 0 0 3 3 3 0 DASH complex subunit Dad1 UPF0449 PF15136.6 CDF39672.1 - 0.49 10.9 9.2 1.6 9.2 9.2 2.1 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 CLP_protease PF00574.23 CDF39672.1 - 0.53 10.1 2.3 0.31 10.9 0.4 1.6 2 0 0 2 2 2 0 Clp protease YabA PF06156.13 CDF39672.1 - 0.62 10.7 9.7 0.86 10.3 5.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 CDF39672.1 - 0.64 9.3 14.2 0.96 8.7 9.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 CDF39672.1 - 0.81 8.5 15.5 0.8 8.5 5.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Mod_r PF07200.13 CDF39672.1 - 1.3 9.1 14.9 0.51 10.4 10.4 2.4 2 1 1 3 3 2 0 Modifier of rudimentary (Mod(r)) protein DUF4407 PF14362.6 CDF39672.1 - 1.7 8.0 7.8 2.8 7.2 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 CDF39672.1 - 2.1 8.5 7.8 2.5 8.3 5.8 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KASH_CCD PF14662.6 CDF39672.1 - 2.4 8.0 16.7 26 4.5 16.1 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH UPF0242 PF06785.11 CDF39672.1 - 3 7.9 16.3 4.5 7.3 13.5 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 CDF39672.1 - 7.3 6.8 12.7 1.7 8.8 4.9 3.2 2 1 1 3 3 3 0 bZIP transcription factor V_ATPase_I PF01496.19 CDF39672.1 - 7.8 4.3 8.0 9 4.1 7.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 CDF39672.1 - 9.1 6.1 14.0 17 5.2 11.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ADSL_C PF10397.9 CDF39672.1 - 9.6 6.8 7.6 1.4 9.6 1.2 2.6 2 1 1 3 3 3 0 Adenylosuccinate lyase C-terminus PCI PF01399.27 CDF39675.1 - 0.00075 20.0 1.6 0.0076 16.7 0.0 3.3 3 1 0 3 3 3 1 PCI domain Syntaxin PF00804.25 CDF39677.1 - 9.1e-16 58.1 0.0 2.5e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 CDF39677.1 - 1.1e-11 44.5 11.8 5.6e-11 42.3 11.8 2.1 1 1 0 1 1 1 1 SNARE domain DUF745 PF05335.13 CDF39677.1 - 0.0039 16.9 0.9 0.066 12.9 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF745) Fusion_gly PF00523.18 CDF39677.1 - 0.012 13.9 1.5 0.017 13.4 1.5 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF2207 PF09972.9 CDF39677.1 - 0.019 13.7 0.1 0.024 13.4 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM154 PF15102.6 CDF39677.1 - 0.15 12.0 1.3 0.22 11.5 1.3 1.3 1 0 0 1 1 1 0 TMEM154 protein family GNVR PF13807.6 CDF39677.1 - 0.84 9.6 4.5 3.2 7.8 4.5 2.0 1 1 0 1 1 1 0 G-rich domain on putative tyrosine kinase DUF2116 PF09889.9 CDF39677.1 - 1.1 9.2 3.6 1.8 8.6 3.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) T2SSF PF00482.23 CDF39677.1 - 4.4 7.3 6.9 2.6 8.0 0.3 3.2 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F Utp21 PF04192.12 CDF39678.1 - 8.6e-38 130.1 0.0 1.4e-37 129.5 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 CDF39678.1 - 1.1e-11 45.1 19.2 0.00046 20.9 0.0 8.2 10 0 0 10 10 10 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39678.1 - 2e-09 37.6 0.0 0.00069 19.9 0.0 5.3 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF697 PF05128.12 CDF39678.1 - 0.15 11.8 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF697) NUMOD1 PF07453.13 CDF39678.1 - 0.15 12.3 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 NUMOD1 domain NPL PF17800.1 CDF39679.1 - 8.3e-14 52.0 0.0 8.3e-14 52.0 0.0 2.4 2 1 0 2 2 2 1 Nucleoplasmin-like domain Nucleoplasmin PF03066.15 CDF39679.1 - 0.0073 16.8 0.6 0.017 15.6 0.0 1.9 2 0 0 2 2 2 1 Nucleoplasmin/nucleophosmin domain PrmA PF06325.13 CDF39681.1 - 2.6e-05 23.8 0.0 3.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 CDF39681.1 - 0.0002 21.3 0.0 0.00032 20.6 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF39681.1 - 0.00042 19.9 0.1 0.0012 18.4 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase small domain PCMT PF01135.19 CDF39681.1 - 0.02 14.7 0.0 0.038 13.8 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CDF39681.1 - 0.046 14.4 0.1 0.13 13.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39681.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 CDF39681.1 - 0.13 11.5 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase L51_S25_CI-B8 PF05047.16 CDF39682.1 - 6.6e-09 35.6 0.0 1.6e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain tRNA-synt_2 PF00152.20 CDF39683.1 - 2.4e-103 345.5 0.0 3.1e-103 345.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDF39683.1 - 3.5e-14 52.5 2.7 8.5e-14 51.3 1.8 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain GAD PF02938.14 CDF39683.1 - 5.6e-13 48.9 0.1 1.1e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 GAD domain tRNA-synt_2d PF01409.20 CDF39683.1 - 7.1e-05 22.4 0.1 0.01 15.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) ATP-synt_DE_N PF02823.16 CDF39683.1 - 0.089 12.7 0.2 0.22 11.4 0.2 1.7 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain PBD PF00786.28 CDF39683.1 - 0.16 12.4 0.0 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 P21-Rho-binding domain Acetyltransf_1 PF00583.25 CDF39684.1 - 1.1e-09 38.5 0.0 1.9e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF39684.1 - 4.2e-06 27.1 0.0 7.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDF39684.1 - 1.6e-05 25.6 0.0 2.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF39684.1 - 0.0051 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CDF39684.1 - 0.015 15.4 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDF39684.1 - 0.027 14.4 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Cyclin_N PF00134.23 CDF39685.1 - 4.4e-16 58.8 0.2 1.3e-13 50.8 0.1 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CDF39685.1 - 9.2e-06 26.0 1.3 3.8e-05 24.0 0.2 2.5 2 2 0 2 2 2 1 Cyclin C-terminal domain Cyclin_C PF02984.19 CDF39685.1 - 0.01 15.9 0.1 0.046 13.8 0.0 2.1 2 1 1 3 3 3 0 Cyclin, C-terminal domain TFIIB PF00382.19 CDF39685.1 - 0.029 14.4 0.3 0.29 11.2 0.1 2.3 2 0 0 2 2 2 0 Transcription factor TFIIB repeat MFS_1 PF07690.16 CDF39686.1 - 5.8e-43 147.2 44.1 5.8e-43 147.2 44.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 CDF39686.1 - 0.014 14.1 13.2 0.026 13.2 13.2 1.5 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Octopine_DH PF02317.17 CDF39689.1 - 1.8e-27 96.3 0.0 2.8e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain ApbA PF02558.16 CDF39689.1 - 0.0062 16.2 0.0 0.0099 15.5 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CDF39689.1 - 0.03 14.9 0.0 0.06 13.9 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Staph_opine_DH PF10100.9 CDF39689.1 - 0.11 11.2 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Staphylopine dehydrogenase APH PF01636.23 CDF39690.1 - 4.4e-08 33.4 0.0 1.1e-07 32.1 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDF39690.1 - 0.00061 19.4 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 CDF39690.1 - 0.008 15.5 0.0 0.022 14.1 0.0 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase CCDC85 PF10226.9 CDF39690.1 - 0.026 14.2 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 CCDC85 family DDE_3 PF13358.6 CDF39692.1 - 2.9e-14 53.1 0.1 5.5e-14 52.1 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease GST_N_2 PF13409.6 CDF39693.1 - 0.0026 18.0 0.2 0.027 14.7 0.0 2.2 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDF39693.1 - 0.013 15.9 0.0 0.037 14.5 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDF39693.1 - 0.088 12.8 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDF39693.1 - 0.2 11.9 0.0 0.31 11.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain XRN_M PF17846.1 CDF39694.1 - 5.6e-86 289.2 0.2 9.1e-85 285.2 0.2 2.2 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 CDF39694.1 - 7.7e-35 120.5 0.0 1.1e-34 120.0 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus SH3_12 PF18129.1 CDF39694.1 - 6.7e-19 67.8 1.2 1.3e-18 66.8 0.3 2.0 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN1_D1 PF18332.1 CDF39694.1 - 2.3e-06 27.5 0.0 4.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain US30 PF17624.2 CDF39695.1 - 8.4 5.3 6.2 17 4.4 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function LSM PF01423.22 CDF39696.1 - 2.5e-16 59.1 0.1 3.4e-16 58.7 0.1 1.2 1 0 0 1 1 1 1 LSM domain Nop PF01798.18 CDF39697.1 - 1.4e-82 276.6 0.1 1.4e-82 276.6 0.1 1.9 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CDF39697.1 - 8.1e-18 64.6 0.7 8.1e-18 64.6 0.7 2.3 2 0 0 2 2 2 1 NOP5NT (NUC127) domain DUF1400 PF07176.11 CDF39697.1 - 0.097 13.0 0.3 0.5 10.6 0.3 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1400) Peptidase_M50 PF02163.22 CDF39698.1 - 0.00068 19.0 0.2 0.00095 18.5 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M50 Pkinase PF00069.25 CDF39700.1 - 3.1e-65 220.2 0.0 4.8e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39700.1 - 3.4e-29 101.9 0.0 4.9e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF39700.1 - 5.1e-08 32.3 0.0 7.5e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF39700.1 - 0.0013 18.7 0.3 0.15 11.9 0.1 2.6 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF39700.1 - 0.0054 16.1 0.0 0.38 10.0 0.0 2.4 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 CDF39700.1 - 0.025 13.9 0.1 0.046 13.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 CDF39700.1 - 0.095 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase AAA PF00004.29 CDF39701.1 - 1.4e-41 142.0 0.0 2.3e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDF39701.1 - 1.1e-19 70.1 0.0 3.7e-19 68.5 0.0 1.9 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CDF39701.1 - 8.3e-09 35.4 4.8 2.1e-08 34.1 4.8 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 CDF39701.1 - 1e-05 25.3 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF39701.1 - 2.1e-05 25.0 0.2 0.00012 22.5 0.0 2.2 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 CDF39701.1 - 3e-05 24.3 0.2 0.0089 16.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CDF39701.1 - 3.4e-05 23.7 0.0 6.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CDF39701.1 - 6.8e-05 22.9 0.0 0.00018 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CDF39701.1 - 0.0001 22.5 0.0 0.0002 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CDF39701.1 - 0.00011 22.3 0.0 0.00033 20.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDF39701.1 - 0.00064 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 CDF39701.1 - 0.0008 18.6 0.0 0.002 17.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_lid_3 PF17862.1 CDF39701.1 - 0.00083 19.1 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 CDF39701.1 - 0.0012 19.4 0.7 0.011 16.3 0.7 2.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDF39701.1 - 0.0024 18.0 0.0 0.007 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CDF39701.1 - 0.003 17.9 0.0 0.0087 16.4 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 CDF39701.1 - 0.0035 17.1 0.0 0.009 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CDF39701.1 - 0.015 15.7 0.0 0.053 14.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDF39701.1 - 0.018 14.9 0.0 0.69 9.8 0.0 2.5 2 1 0 2 2 1 0 NACHT domain Sigma54_activat PF00158.26 CDF39701.1 - 0.033 13.9 0.0 0.47 10.1 0.0 2.6 2 1 1 3 3 3 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 CDF39701.1 - 0.034 13.5 0.0 0.07 12.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDF39701.1 - 0.034 13.7 0.0 0.1 12.1 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 CDF39701.1 - 0.093 12.2 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 CDF39701.1 - 0.097 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Cytidylate_kin PF02224.18 CDF39701.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase Viral_helicase1 PF01443.18 CDF39701.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 CDF39701.1 - 0.16 11.6 0.3 0.82 9.2 0.1 2.0 1 1 0 2 2 2 0 AAA domain Neuromodulin PF06614.11 CDF39703.1 - 0.35 11.0 6.7 0.5 10.5 6.7 1.1 1 0 0 1 1 1 0 Neuromodulin Iso_dh PF00180.20 CDF39704.1 - 3.1e-75 253.5 0.2 4.1e-75 253.1 0.2 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Cnd1 PF12717.7 CDF39705.1 - 2.2e-05 24.6 0.5 0.00014 22.0 0.4 2.1 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CDF39705.1 - 6.5e-05 22.8 10.0 0.0026 17.8 0.3 4.1 3 1 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 CDF39705.1 - 0.00025 21.5 6.4 0.017 15.6 1.7 4.9 4 2 2 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.6 CDF39705.1 - 0.00029 21.2 8.9 0.0019 18.6 5.5 3.4 2 1 1 3 3 3 2 HEAT repeats Arm PF00514.23 CDF39705.1 - 0.00059 19.8 0.7 0.0067 16.4 0.2 2.8 2 1 0 2 2 2 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 CDF39705.1 - 0.00078 18.1 0.2 0.0015 17.2 0.2 1.4 1 1 0 1 1 1 1 Adaptin N terminal region Ist1 PF03398.14 CDF39705.1 - 0.036 14.0 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF4042 PF13251.6 CDF39705.1 - 0.11 12.2 0.3 1.1 8.9 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) Fes1 PF08609.10 CDF39706.1 - 0.0021 18.9 1.3 0.0025 18.6 0.2 1.6 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 DUF4630 PF15443.6 CDF39706.1 - 0.0034 17.6 0.5 0.004 17.4 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4630) RE_TdeIII PF09520.10 CDF39706.1 - 0.057 13.1 0.1 0.058 13.0 0.1 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease, TdeIII Catalase_C PF18011.1 CDF39706.1 - 0.091 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases DZR PF12773.7 CDF39707.1 - 0.25 11.4 8.0 0.83 9.7 0.1 3.6 4 0 0 4 4 4 0 Double zinc ribbon GST_C_3 PF14497.6 CDF39709.1 - 0.0011 19.1 0.0 0.0013 18.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDF39709.1 - 0.018 15.3 0.0 0.018 15.2 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDF39709.1 - 0.064 13.3 0.0 0.072 13.1 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-UBR PF02207.20 CDF39710.1 - 1.5e-07 31.4 10.6 1.5e-07 31.4 10.6 3.5 3 1 1 4 4 4 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.29 CDF39710.1 - 1.4e-06 28.0 7.2 1.4e-06 28.0 7.2 3.1 3 1 0 3 3 3 1 PHD-finger DUF3094 PF11293.8 CDF39711.1 - 1 9.1 2.7 19 5.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) Sel1 PF08238.12 CDF39714.1 - 3.5e-45 151.4 9.4 0.00014 22.4 0.0 12.6 13 0 0 13 13 13 10 Sel1 repeat TPR_16 PF13432.6 CDF39714.1 - 3.8e-07 30.6 20.6 3.6 8.3 0.0 8.0 7 2 1 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDF39714.1 - 1.7e-06 27.7 6.3 26 5.2 0.0 7.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF39714.1 - 5.3e-06 26.7 8.8 81 4.2 0.0 9.4 11 0 0 11 11 11 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF39714.1 - 0.00089 19.5 9.9 0.072 13.4 0.0 5.3 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF39714.1 - 0.0053 17.1 1.2 4.1 8.0 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat PPR_long PF17177.4 CDF39714.1 - 0.07 12.5 0.4 6.7 6.0 0.0 4.1 5 1 0 5 5 5 0 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 CDF39714.1 - 0.23 12.4 21.5 9.1 7.4 0.0 8.1 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF39714.1 - 4.4 7.3 14.2 64 3.6 0.0 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat MIT PF04212.18 CDF39714.1 - 5.3 7.2 14.5 25 5.0 0.0 6.7 10 0 0 10 10 10 0 MIT (microtubule interacting and transport) domain PAF PF15715.5 CDF39716.1 - 0.03 14.9 1.9 0.049 14.2 1.9 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain YCII PF03795.14 CDF39717.1 - 1.7e-22 79.6 0.0 7.2e-13 48.8 0.0 2.1 2 0 0 2 2 2 2 YCII-related domain C_LFY_FLO PF17538.2 CDF39717.1 - 0.017 14.6 0.1 0.67 9.4 0.0 2.1 2 0 0 2 2 2 0 DNA Binding Domain (C-terminal) Leafy/Floricaula Methyltransf_11 PF08241.12 CDF39718.1 - 1.2e-11 45.0 0.0 2.3e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF39718.1 - 2e-07 31.6 0.0 6.2e-07 30.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF39718.1 - 2e-07 30.9 0.0 2.9e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF39718.1 - 7.9e-05 23.3 0.0 0.00014 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 CDF39718.1 - 0.00011 20.9 0.0 0.00016 20.4 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 CDF39718.1 - 0.00056 19.3 0.0 0.0008 18.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 CDF39718.1 - 0.0018 17.9 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 CDF39718.1 - 0.0066 16.3 0.0 0.0093 15.8 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_23 PF13489.6 CDF39718.1 - 0.025 14.4 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 CDF39718.1 - 0.052 13.0 0.0 0.074 12.5 0.0 1.1 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain CpcD PF01383.21 CDF39718.1 - 0.18 12.1 0.4 0.46 10.8 0.4 1.7 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain PBS_linker_poly PF00427.21 CDF39720.1 - 1.6e-37 128.4 0.2 2.5e-37 127.7 0.2 1.3 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide TetR PF13972.6 CDF39720.1 - 0.07 12.8 0.4 0.17 11.6 0.4 1.7 1 0 0 1 1 1 0 Bacterial transcriptional repressor WD40 PF00400.32 CDF39721.1 - 3.2e-11 43.6 0.2 9e-06 26.3 0.0 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39721.1 - 5.7e-10 39.4 0.0 1.8e-05 25.0 0.0 2.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF39721.1 - 0.089 12.7 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 CDF39723.1 - 0.018 15.9 0.2 0.036 14.9 0.2 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat LA-virus_coat PF09220.10 CDF39728.1 - 8.9e-27 93.8 0.0 1.3e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 L-A virus, major coat protein Pkinase PF00069.25 CDF39730.1 - 3.1e-38 131.6 0.0 4.6e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39730.1 - 6.6e-22 78.0 0.0 9.9e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF39730.1 - 6.5e-08 32.2 0.0 1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PIF1 PF05970.14 CDF39734.1 - 7.5e-42 143.8 0.0 2.2e-20 73.2 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase Herpes_Helicase PF02689.14 CDF39734.1 - 0.01 13.8 0.0 0.014 13.3 0.0 1.1 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF39734.1 - 0.054 13.3 0.1 0.2 11.5 0.1 2.1 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain Trp_Tyr_perm PF03222.13 CDF39737.1 - 2.4e-06 26.9 12.8 0.0025 16.9 0.0 3.3 3 1 0 3 3 3 3 Tryptophan/tyrosine permease family Aa_trans PF01490.18 CDF39737.1 - 7.1e-06 25.0 0.4 7.1e-06 25.0 0.4 2.1 3 0 0 3 3 3 1 Transmembrane amino acid transporter protein Citrate_bind PF16114.5 CDF39738.1 - 1.8e-72 242.5 0.0 2.8e-72 242.0 0.0 1.3 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 CDF39738.1 - 2.8e-12 46.7 0.0 1.1e-11 44.7 0.0 1.9 1 1 1 2 2 2 1 ATP-grasp domain Aldedh PF00171.22 CDF39739.1 - 1.3e-98 330.5 0.0 2e-98 329.9 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pro_dh PF01619.18 CDF39739.1 - 3.3e-59 200.9 0.0 5.5e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Proline dehydrogenase NolB PF17398.2 CDF39739.1 - 0.11 12.8 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 Nodulation protein NolB OSCP PF00213.18 CDF39740.1 - 4.4e-38 131.1 0.3 6.4e-38 130.6 0.1 1.3 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit Psb28 PF03912.14 CDF39740.1 - 0.058 13.7 0.1 0.24 11.7 0.0 1.9 2 0 0 2 2 2 0 Psb28 protein Sep15_SelM PF08806.11 CDF39741.1 - 2.1e-15 56.6 0.1 3.1e-15 56.1 0.1 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain HOIP-UBA PF16678.5 CDF39742.1 - 0.025 14.6 0.4 0.037 14.0 0.4 1.5 1 1 0 1 1 1 0 HOIP UBA domain pair Mut7-C PF01927.16 CDF39742.1 - 0.056 13.5 0.3 0.06 13.5 0.3 1.0 1 0 0 1 1 1 0 Mut7-C RNAse domain UBA PF00627.31 CDF39742.1 - 0.082 12.8 0.3 0.13 12.2 0.3 1.3 1 0 0 1 1 1 0 UBA/TS-N domain TRAP-gamma PF07074.12 CDF39743.1 - 1.1e-09 38.1 2.5 3.6e-05 23.4 0.1 2.0 2 0 0 2 2 2 2 Translocon-associated protein, gamma subunit (TRAP-gamma) HTH_16 PF12645.7 CDF39743.1 - 0.18 11.9 0.1 0.31 11.1 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain PhoR PF11808.8 CDF39743.1 - 2 8.9 6.2 0.3 11.5 0.8 2.1 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR Vac_ImportDeg PF09783.9 CDF39744.1 - 2.1e-44 151.2 0.0 2.5e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein DEAD PF00270.29 CDF39745.1 - 4.1e-47 160.2 0.0 6.1e-47 159.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF39745.1 - 3.1e-26 91.9 0.0 7.8e-25 87.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF39745.1 - 2.8e-08 33.9 0.0 6.8e-08 32.7 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 CDF39745.1 - 0.19 10.5 0.1 41 2.8 0.0 3.5 3 1 1 4 4 4 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 LMBR1 PF04791.16 CDF39745.1 - 4.7 6.0 5.0 7.1 5.4 5.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Hint PF01079.20 CDF39748.1 - 9.3e-28 97.2 1.6 1.9e-27 96.2 1.6 1.4 1 1 0 1 1 1 1 Hint module Vint PF14623.6 CDF39748.1 - 0.011 15.5 0.0 0.023 14.5 0.0 1.5 1 1 0 1 1 1 0 Hint-domain Alph_Pro_TM PF09608.10 CDF39748.1 - 0.017 14.9 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) Fringe PF02434.16 CDF39749.1 - 3.8e-07 29.8 0.1 5e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Fringe-like Pkinase PF00069.25 CDF39750.1 - 5.2e-56 189.9 0.0 7.3e-56 189.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39750.1 - 1e-37 129.8 0.0 1.5e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-CHCC PF10276.9 CDF39751.1 - 1.5e-13 50.5 0.7 2.1e-13 50.0 0.7 1.2 1 0 0 1 1 1 1 Zinc-finger domain zf_C2H2_6 PF18450.1 CDF39751.1 - 0.058 13.1 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Zinc Finger domain Chloroa_b-bind PF00504.21 CDF39753.1 - 5e-32 111.7 0.1 6.5e-32 111.3 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein UQ_con PF00179.26 CDF39754.1 - 1.7e-31 108.7 0.0 2e-31 108.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF39754.1 - 0.00041 20.1 0.0 0.00046 19.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 CDF39754.1 - 0.00091 18.9 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 Prok-E2_A PF14457.6 CDF39754.1 - 0.0052 16.4 0.2 0.007 16.0 0.2 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family A RWD PF05773.22 CDF39754.1 - 0.025 14.9 0.0 0.038 14.3 0.0 1.5 1 1 0 1 1 1 0 RWD domain ABC_trans_aux PF03886.13 CDF39754.1 - 0.083 12.5 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 ABC-type transport auxiliary lipoprotein component ASFV_J13L PF05568.11 CDF39756.1 - 1.9 8.2 5.7 1.1 9.0 1.9 1.9 1 1 1 2 2 2 0 African swine fever virus J13L protein Peptidase_S41 PF03572.18 CDF39757.1 - 6.5e-49 165.7 0.7 1e-48 165.1 0.7 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_6 PF17820.1 CDF39757.1 - 1.7e-10 40.6 0.1 4.4e-10 39.3 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDF39757.1 - 2.1e-09 37.6 0.6 8.8e-08 32.4 0.1 2.6 2 1 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDF39757.1 - 1.4e-06 28.6 0.1 2.5e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_C1 PF14684.6 CDF39757.1 - 0.038 14.0 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 Tricorn protease C1 domain MGDG_synth PF06925.11 CDF39758.1 - 6.7e-26 91.4 0.0 9.1e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 CDF39758.1 - 3.9e-12 46.4 0.0 5.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 CDF39758.1 - 4.5e-08 33.6 0.0 4.2e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDF39758.1 - 4.5e-06 26.3 0.0 7.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDF39758.1 - 0.026 14.5 2.9 0.41 10.6 1.4 2.7 2 1 0 2 2 2 0 Glycosyltransferase Family 4 NAD_binding_3 PF03447.16 CDF39758.1 - 0.14 12.8 0.0 0.37 11.4 0.0 1.7 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Cpn60_TCP1 PF00118.24 CDF39760.1 - 8.1e-150 499.7 10.0 9.3e-150 499.5 10.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pro_dh-DNA_bdg PF14850.6 CDF39760.1 - 0.0015 19.0 0.6 0.0071 16.9 0.3 2.2 2 0 0 2 2 2 1 DNA-binding domain of Proline dehydrogenase DEAD PF00270.29 CDF39761.1 - 3.6e-51 173.4 0.0 6.1e-51 172.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF39761.1 - 1.8e-30 105.5 0.0 4.4e-29 101.0 0.0 2.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF39761.1 - 8.8e-07 29.1 0.0 2e-06 27.9 0.0 1.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDF39761.1 - 0.026 14.2 0.0 0.074 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain IF4E PF01652.18 CDF39762.1 - 3.2e-45 153.8 0.0 3.9e-45 153.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Mito_carr PF00153.27 CDF39764.1 - 1.9e-31 107.9 0.4 1.2e-18 66.8 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Urease_alpha PF00449.20 CDF39766.1 - 0.036 14.4 0.1 0.06 13.7 0.1 1.3 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain FtsJ PF01728.19 CDF39767.1 - 1.1e-49 169.0 0.0 2.2e-49 168.0 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 CDF39767.1 - 2.1e-40 138.6 21.1 2.1e-40 138.6 21.1 3.5 3 0 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.8 CDF39767.1 - 1.9e-36 125.3 11.7 1.9e-36 125.3 11.7 4.4 3 2 1 4 4 4 1 Domain of unknown function (DUF3381) FapA PF03961.13 CDF39767.1 - 1 7.9 11.9 0.019 13.6 2.9 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A Peptidase_M20 PF01546.28 CDF39769.1 - 1.1e-23 84.0 0.0 2.4e-23 82.9 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 CDF39769.1 - 5e-09 36.1 0.0 1.1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 CDF39769.1 - 0.00065 19.6 0.0 0.002 18.0 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain Phage_ASH PF10554.9 CDF39769.1 - 0.026 14.9 0.2 0.07 13.5 0.0 1.8 2 0 0 2 2 2 0 Ash protein family Uricase PF01014.18 CDF39770.1 - 1.9e-51 173.7 0.1 2.4e-29 102.3 0.1 2.1 2 0 0 2 2 2 2 Uricase SART-1 PF03343.13 CDF39771.1 - 6.4e-49 167.1 45.5 1.6e-20 73.2 1.6 4.8 2 1 2 4 4 4 4 SART-1 family TPR_2 PF07719.17 CDF39772.1 - 3.4e-17 61.1 0.3 1e-05 25.2 0.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDF39772.1 - 2.1e-16 58.9 0.1 3.2e-07 29.9 0.1 5.0 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF39772.1 - 8.9e-13 48.7 6.4 3.2e-07 30.9 0.7 3.9 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF39772.1 - 1.2e-11 44.1 1.9 0.0024 17.5 0.1 4.7 4 1 1 5 5 5 3 TPR repeat TPR_12 PF13424.6 CDF39772.1 - 2.4e-10 40.6 0.0 0.0074 16.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDF39772.1 - 2.8e-09 36.4 0.0 0.012 15.6 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDF39772.1 - 1.4e-07 31.4 0.1 0.0088 16.4 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF39772.1 - 3.2e-07 30.6 5.0 0.1 13.5 0.1 5.3 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF39772.1 - 3.3e-07 30.0 0.4 0.0065 16.6 0.0 4.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDF39772.1 - 1.5e-06 28.6 1.9 0.022 15.3 0.1 3.6 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_4 PF07721.14 CDF39772.1 - 2.9e-06 27.4 1.1 0.11 13.2 0.0 3.6 3 0 0 3 3 2 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 CDF39772.1 - 5.6e-06 25.7 0.0 0.0039 16.6 0.1 3.3 3 0 0 3 3 3 1 SHNi-TPR TPR_10 PF13374.6 CDF39772.1 - 1.3e-05 24.9 3.5 1.4 8.9 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_21 PF09976.9 CDF39772.1 - 4.2e-05 23.4 2.1 0.0018 18.0 0.2 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 CDF39772.1 - 0.00011 22.7 3.7 21 6.0 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDF39772.1 - 0.00033 20.7 0.2 0.16 12.1 0.0 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF39772.1 - 0.13 12.5 0.0 0.7 10.2 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 HC2 PF07382.11 CDF39773.1 - 0.0098 16.0 2.5 0.0098 16.0 2.5 1.5 1 1 0 1 1 1 1 Histone H1-like nucleoprotein HC2 DUF5596 PF18082.1 CDF39773.1 - 0.022 14.6 0.0 3.8 7.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5596) Na_H_Exchanger PF00999.21 CDF39777.1 - 1.2e-68 231.7 36.5 1.2e-68 231.7 36.5 1.3 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CDF39777.1 - 7.3e-10 39.1 0.0 1.6e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain DUF996 PF06195.13 CDF39777.1 - 0.064 13.5 2.2 0.11 12.8 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF996) Sacchrp_dh_NADP PF03435.18 CDF39777.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pro_isomerase PF00160.21 CDF39778.1 - 6.3e-24 85.0 0.0 1.1e-23 84.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PsbQ PF05757.11 CDF39778.1 - 0.34 10.6 4.5 0.71 9.6 4.5 1.6 1 1 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) zf-UBP PF02148.19 CDF39781.1 - 5e-18 65.2 4.6 3e-17 62.7 4.6 2.4 1 1 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.12 CDF39781.1 - 7.1e-14 51.8 0.0 1.3e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-RING_2 PF13639.6 CDF39781.1 - 6.5e-08 32.8 3.7 6.5e-08 32.8 3.7 2.6 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDF39781.1 - 2.1e-06 27.5 4.2 2.1e-06 27.5 4.2 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF39781.1 - 0.0002 21.0 0.6 0.0002 21.0 0.6 2.5 2 0 0 2 2 1 1 RING-like zinc finger Golgin_A5 PF09787.9 CDF39781.1 - 0.00023 20.7 4.9 0.00034 20.2 4.9 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 zf-rbx1 PF12678.7 CDF39781.1 - 0.00072 19.8 3.2 0.00072 19.8 3.2 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CDF39781.1 - 0.0008 19.2 3.6 0.0008 19.2 3.6 2.6 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CDF39781.1 - 0.0049 16.6 2.7 0.0049 16.6 2.7 2.0 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 CDF39781.1 - 0.0061 16.2 4.8 0.0061 16.2 4.8 2.7 1 1 1 2 2 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CDF39781.1 - 0.0077 16.2 0.1 0.0077 16.2 0.1 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDF39781.1 - 0.0095 15.8 4.1 0.0095 15.8 4.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ATG16 PF08614.11 CDF39781.1 - 0.011 15.9 6.5 0.024 14.8 6.5 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Filament PF00038.21 CDF39781.1 - 0.015 14.9 6.6 0.023 14.3 6.6 1.2 1 0 0 1 1 1 0 Intermediate filament protein zf-C3HC4 PF00097.25 CDF39781.1 - 0.015 15.1 6.9 0.015 15.1 6.9 2.3 1 1 1 2 2 1 0 Zinc finger, C3HC4 type (RING finger) TACC_C PF05010.14 CDF39781.1 - 0.03 14.1 4.0 0.052 13.3 3.2 1.5 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal OxoGdeHyase_C PF16870.5 CDF39781.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase C-terminal DUF1664 PF07889.12 CDF39781.1 - 0.1 12.6 3.0 0.73 9.9 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BicD PF09730.9 CDF39781.1 - 0.11 11.0 8.0 0.17 10.3 0.9 2.1 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D TPR_MLP1_2 PF07926.12 CDF39781.1 - 0.13 12.3 10.5 2.6 8.1 10.5 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein zf-C3H2C3 PF17122.5 CDF39781.1 - 0.18 11.8 3.9 0.52 10.4 3.9 1.8 1 0 0 1 1 1 0 Zinc-finger TMF_DNA_bd PF12329.8 CDF39781.1 - 0.29 11.2 7.2 1.4 9.0 0.4 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Phage_GP20 PF06810.11 CDF39781.1 - 0.31 10.8 3.9 0.64 9.8 3.5 1.6 1 1 0 1 1 1 0 Phage minor structural protein GP20 Macoilin PF09726.9 CDF39781.1 - 0.37 9.3 3.8 0.51 8.8 3.8 1.1 1 0 0 1 1 1 0 Macoilin family zf-UBP_var PF17807.1 CDF39781.1 - 0.4 10.5 6.0 0.065 13.0 1.7 1.8 2 0 0 2 2 2 0 Variant UBP zinc finger Seryl_tRNA_N PF02403.22 CDF39781.1 - 0.46 10.7 7.8 1.1 9.5 7.8 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 CDF39781.1 - 0.47 9.8 6.3 0.78 9.1 6.3 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 CDF39781.1 - 0.61 10.5 8.8 0.76 10.2 2.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) PspA_IM30 PF04012.12 CDF39781.1 - 0.76 9.3 11.4 1.4 8.5 11.4 1.3 1 0 0 1 1 1 0 PspA/IM30 family Uso1_p115_C PF04871.13 CDF39781.1 - 0.94 9.9 8.8 1.7 9.0 8.8 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 CDF39781.1 - 0.95 10.0 12.2 5.1 7.6 10.4 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 CDF39781.1 - 1.6 8.7 9.8 23 5.0 6.2 2.2 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HIP1_clath_bdg PF16515.5 CDF39781.1 - 2.7 8.6 8.6 14 6.4 4.8 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 CDF39781.1 - 3 7.9 4.7 4.6 7.3 4.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus betaPIX_CC PF16523.5 CDF39781.1 - 6.5 6.6 7.2 5.8 6.8 0.8 2.7 2 1 0 2 2 2 0 betaPIX coiled coil DUF4407 PF14362.6 CDF39781.1 - 9.1 5.5 9.0 3.5 6.9 2.4 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fer2 PF00111.27 CDF39782.1 - 4.1e-12 45.9 0.0 4.8e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 CDF39782.1 - 0.067 13.2 0.2 0.082 12.9 0.2 1.3 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF2499 PF10693.9 CDF39783.1 - 0.12 12.7 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2499) RIO1 PF01163.22 CDF39786.1 - 1.3e-27 96.6 0.0 1.5e-27 96.4 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Glyoxalase PF00903.25 CDF39788.1 - 4.2e-14 52.8 0.2 1.1e-05 25.6 0.1 2.9 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDF39788.1 - 9.7e-13 48.4 0.2 1.7e-05 25.1 0.1 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CHAP PF05257.16 CDF39788.1 - 0.021 15.4 5.7 0.2 12.3 1.2 2.7 2 1 0 2 2 2 0 CHAP domain Glyoxalase_6 PF18029.1 CDF39788.1 - 0.064 14.1 2.3 0.4 11.5 0.2 2.8 2 2 0 2 2 2 0 Glyoxalase-like domain CAP_N PF01213.19 CDF39789.1 - 5.4e-36 124.7 0.0 7e-19 68.4 0.0 2.0 1 1 1 2 2 2 2 Adenylate cyclase associated (CAP) N terminal Meth_synt_2 PF01717.18 CDF39789.1 - 0.034 13.4 0.0 0.059 12.6 0.0 1.4 1 0 0 1 1 1 0 Cobalamin-independent synthase, Catalytic domain DUF630 PF04783.12 CDF39789.1 - 0.042 14.0 0.1 2.3 8.4 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF630) DUF2621 PF11084.8 CDF39789.1 - 0.15 12.1 0.5 1 9.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) Chloroa_b-bind PF00504.21 CDF39790.1 - 4e-33 115.2 0.0 5.1e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Lactamase_B_2 PF12706.7 CDF39793.1 - 1.9e-07 30.8 0.0 4e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF39793.1 - 0.13 12.2 2.6 3.1 7.7 1.2 2.4 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily S1 PF00575.23 CDF39794.1 - 3.7e-16 59.2 11.0 1.8e-10 41.0 0.7 4.2 3 1 0 3 3 3 2 S1 RNA binding domain CsrA PF02599.16 CDF39794.1 - 0.14 12.1 0.7 1.3 9.0 0.1 2.8 3 0 0 3 3 3 0 Global regulator protein family adh_short PF00106.25 CDF39795.1 - 6e-33 114.0 0.1 8e-33 113.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF39795.1 - 7e-20 71.6 0.0 1e-19 71.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDF39795.1 - 2.3e-05 24.4 0.1 3.5e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CDF39795.1 - 0.0027 16.9 0.1 0.0045 16.2 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CDF39795.1 - 0.018 14.5 0.8 0.14 11.6 0.8 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Mur_ligase_M PF08245.12 CDF39796.1 - 4.8e-10 39.8 0.0 9.6e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Mur ligase middle domain AP_endonuc_2 PF01261.24 CDF39796.1 - 0.027 13.9 0.0 0.19 11.1 0.0 2.1 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Mur_ligase_C PF02875.21 CDF39796.1 - 0.096 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Sigma70_r2 PF04542.14 CDF39797.1 - 1.2e-16 60.2 0.3 2.4e-16 59.2 0.3 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CDF39797.1 - 1.9e-14 52.9 0.9 8.2e-14 50.9 0.6 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r3 PF04539.16 CDF39797.1 - 2.1e-12 47.0 1.2 4.6e-06 26.6 0.3 3.3 3 0 0 3 3 3 2 Sigma-70 region 3 YdaS_antitoxin PF15943.5 CDF39797.1 - 0.022 14.6 0.0 20 5.2 0.0 3.4 3 0 0 3 3 3 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Sigma70_r4_2 PF08281.12 CDF39797.1 - 0.051 13.3 1.3 0.7 9.6 0.3 3.2 3 1 0 3 3 3 0 Sigma-70, region 4 HTH_28 PF13518.6 CDF39797.1 - 0.055 13.6 0.0 16 5.7 0.0 3.7 4 0 0 4 4 4 0 Helix-turn-helix domain WD40 PF00400.32 CDF39798.1 - 7.5e-85 276.6 48.5 1.1e-07 32.4 0.3 12.0 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39798.1 - 4.6e-15 55.7 20.0 0.97 9.8 0.0 9.7 2 1 9 11 11 11 9 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF39798.1 - 1e-11 44.5 0.0 2.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Nup160 PF11715.8 CDF39798.1 - 4e-05 22.5 12.8 8.4 4.9 0.0 8.5 1 1 6 9 9 9 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF39798.1 - 0.64 8.9 5.5 20 4.0 0.0 5.2 4 2 2 7 7 7 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 CDF39798.1 - 6.9 6.8 5.2 1.2e+02 2.8 0.0 5.2 7 0 0 7 7 7 0 WD domain, G-beta repeat FBA PF04300.13 CDF39799.1 - 2.6e-06 27.3 0.0 4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 F-box associated region PhnG PF06754.12 CDF39799.1 - 0.013 15.4 0.1 0.015 15.2 0.1 1.2 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG Peptidase_C53 PF05550.11 CDF39802.1 - 0.092 12.4 0.9 0.13 12.0 0.9 1.3 1 0 0 1 1 1 0 Pestivirus Npro endopeptidase C53 DnaJ PF00226.31 CDF39803.1 - 5.3e-21 74.5 0.1 9.6e-21 73.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Ephrin_rec_like PF07699.13 CDF39806.1 - 5.4e-44 147.7 133.6 1.2e-08 34.6 6.8 15.8 8 5 7 16 16 16 12 Putative ephrin-receptor like NCD3G PF07562.14 CDF39806.1 - 4e-15 55.5 116.1 0.0088 16.0 0.6 15.0 8 4 6 15 15 15 12 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDF39806.1 - 0.028 14.8 0.5 0.028 14.8 0.5 18.8 7 6 13 20 20 20 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 CDF39807.1 - 3.7e-30 103.4 111.0 2.2e-08 33.7 4.4 13.7 6 5 9 15 15 15 11 Putative ephrin-receptor like NCD3G PF07562.14 CDF39807.1 - 1.1e-13 50.9 97.5 0.012 15.5 2.7 12.0 8 3 3 12 12 12 8 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDF39807.1 - 0.57 10.6 0.1 0.14 12.6 0.8 16.3 7 5 10 17 17 17 0 TNFR/NGFR cysteine-rich region WD40 PF00400.32 CDF39810.1 - 1.9e-68 224.7 43.9 3.2e-07 30.9 0.1 11.5 11 0 0 11 11 11 11 WD domain, G-beta repeat TIR_2 PF13676.6 CDF39810.1 - 7.7e-19 68.4 0.0 6.6e-17 62.2 0.0 2.9 2 0 0 2 2 2 1 TIR domain ANAPC4_WD40 PF12894.7 CDF39810.1 - 6.7e-17 61.6 15.8 0.0059 16.9 0.0 8.9 1 1 8 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF39810.1 - 3.6e-15 55.8 0.0 6.5e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF39810.1 - 1.3e-09 38.1 0.0 2.9e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 TIR domain Nup160 PF11715.8 CDF39810.1 - 7.5e-06 24.9 11.8 2.2 6.8 0.0 8.3 5 2 2 9 9 9 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF39810.1 - 7.2e-05 21.9 3.6 19 4.1 0.0 6.7 1 1 6 8 8 8 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 CDF39810.1 - 0.0012 19.2 0.2 0.0049 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain PQQ_3 PF13570.6 CDF39810.1 - 0.02 15.4 30.4 6.2 7.4 0.1 8.6 3 3 7 10 10 10 0 PQQ-like domain WD40_like PF17005.5 CDF39810.1 - 0.042 13.2 0.0 69 2.6 0.0 4.9 6 1 0 6 6 6 0 WD40-like domain TIR-like PF10137.9 CDF39810.1 - 0.048 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain WD40 PF00400.32 CDF39811.1 - 4.1e-46 154.0 19.7 4.2e-08 33.7 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF39811.1 - 1.2e-14 54.4 4.1 3.5e-05 24.0 0.0 6.3 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF39811.1 - 7.1e-06 24.9 5.3 2.6 6.6 0.0 5.8 3 2 3 7 7 7 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF39811.1 - 8.6e-05 21.7 0.5 9.5 5.1 0.0 5.0 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WSC PF01822.19 CDF39811.1 - 0.0083 16.3 0.2 0.023 14.9 0.2 1.7 1 0 0 1 1 1 1 WSC domain PQQ_3 PF13570.6 CDF39811.1 - 0.027 15.0 13.9 11 6.6 0.5 5.9 4 2 0 4 4 4 0 PQQ-like domain DUF727 PF05303.12 CDF39811.1 - 0.7 10.0 6.7 65 3.7 0.0 5.2 6 2 1 7 7 7 0 Protein of unknown function (DUF727) WD40 PF00400.32 CDF39812.1 - 2.5e-67 221.1 39.8 2.9e-08 34.2 0.2 10.6 10 0 0 10 10 10 10 WD domain, G-beta repeat TIR_2 PF13676.6 CDF39812.1 - 8.3e-17 61.9 0.0 2.7e-15 57.0 0.0 2.7 2 0 0 2 2 2 1 TIR domain ANAPC4_WD40 PF12894.7 CDF39812.1 - 3e-16 59.5 14.2 0.0025 18.1 0.0 7.6 1 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF39812.1 - 3.1e-15 56.1 0.0 5.6e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TIR PF01582.20 CDF39812.1 - 2.1e-08 34.2 0.0 4.6e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain Nup160 PF11715.8 CDF39812.1 - 3.7e-05 22.6 7.2 5.2 5.6 0.0 7.1 5 2 2 8 8 8 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF39812.1 - 0.00013 21.0 2.8 3.1 6.7 0.0 5.9 1 1 5 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF39812.1 - 0.00063 19.2 0.0 5.6 6.2 0.0 4.8 7 0 0 7 7 7 2 WD40-like domain AAA_22 PF13401.6 CDF39812.1 - 0.0011 19.3 0.1 0.0051 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain WSC PF01822.19 CDF39812.1 - 0.012 15.7 0.1 0.033 14.4 0.1 1.6 1 0 0 1 1 1 0 WSC domain TIR-like PF10137.9 CDF39812.1 - 0.06 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Glyoxalase PF00903.25 CDF39813.1 - 3.2e-28 98.5 0.1 3.7e-13 49.8 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDF39813.1 - 2.9e-21 75.8 0.0 4.6e-10 39.8 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDF39813.1 - 1.5e-08 35.4 0.0 0.003 18.3 0.0 3.2 3 0 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CDF39813.1 - 1.9e-08 34.6 0.0 0.01 16.0 0.0 4.0 2 2 0 2 2 2 2 Glyoxalase-like domain TxDE PF18711.1 CDF39813.1 - 0.002 18.2 0.0 1.4 9.1 0.0 3.3 3 0 0 3 3 3 1 Toxoflavin-degrading enzyme Pfk_N PF18468.1 CDF39813.1 - 0.065 13.7 0.2 0.54 10.7 0.0 2.5 3 0 0 3 3 3 0 Phosphofructokinase N-terminal domain yeast Glyco_hydro_63 PF03200.16 CDF39814.1 - 2.3e-133 445.6 0.0 1.4e-131 439.6 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 CDF39814.1 - 1.1e-27 97.7 0.0 1.8e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain FGGY_N PF00370.21 CDF39815.1 - 5.5e-55 186.6 0.0 6.9e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CDF39815.1 - 4.1e-22 78.9 0.5 6.5e-22 78.2 0.5 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain HSP70 PF00012.20 CDF39815.1 - 0.26 9.4 0.0 0.38 8.9 0.0 1.2 1 0 0 1 1 1 0 Hsp70 protein ATP-synt_ab PF00006.25 CDF39816.1 - 4.7e-106 353.2 0.0 6.6e-106 352.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 CDF39816.1 - 5.1e-46 155.5 0.0 1.1e-45 154.5 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 CDF39816.1 - 3.1e-13 50.0 1.1 3.1e-13 50.0 1.1 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DnaJ PF00226.31 CDF39817.1 - 3.1e-07 30.4 0.0 6.6e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain MORN_2 PF07661.13 CDF39817.1 - 4e-05 23.4 1.7 0.0066 16.5 0.1 3.5 3 0 0 3 3 3 2 MORN repeat variant SET PF00856.28 CDF39818.1 - 3.5e-07 30.8 0.0 6.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 SET domain Acetyltransf_1 PF00583.25 CDF39820.1 - 9.5e-13 48.4 0.0 1.9e-12 47.4 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDF39820.1 - 6.2e-09 35.9 0.1 5.2e-08 32.9 0.0 2.3 1 1 2 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF39820.1 - 3.2e-08 33.9 0.1 1.4e-07 31.9 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF39820.1 - 5.3e-08 32.7 0.0 1.5e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CDF39820.1 - 0.015 16.0 0.1 0.055 14.1 0.1 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 CDF39821.1 - 1.6e-63 214.6 0.0 2.2e-63 214.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39821.1 - 9.4e-42 143.1 0.0 1.5e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Arm PF00514.23 CDF39821.1 - 5.7e-07 29.4 0.2 0.011 15.8 0.0 3.8 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Kinase-like PF14531.6 CDF39821.1 - 3.1e-05 23.4 0.0 0.0022 17.4 0.0 2.6 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDF39821.1 - 0.00049 19.5 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5578 PF17741.1 CDF39821.1 - 0.078 12.4 0.5 10 5.4 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5578) Pkinase_fungal PF17667.1 CDF39821.1 - 0.081 11.7 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 CDF39821.1 - 0.22 11.2 0.0 0.37 10.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 SprT-like PF10263.9 CDF39824.1 - 4.3e-22 78.1 0.0 1.3e-21 76.6 0.0 1.8 1 0 0 1 1 1 1 SprT-like family RNF220 PF15926.5 CDF39824.1 - 1e-08 35.1 11.5 0.002 17.8 1.5 3.3 3 0 0 3 3 3 3 E3 ubiquitin-protein ligase RNF220 DNA_ligase_ZBD PF03119.16 CDF39824.1 - 0.003 17.6 9.9 0.45 10.6 0.1 3.6 3 0 0 3 3 3 2 NAD-dependent DNA ligase C4 zinc finger domain PRP21_like_P PF12230.8 CDF39824.1 - 0.014 15.2 4.0 9.6 6.0 0.2 3.3 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein zf-CpG_bind_C PF12269.8 CDF39824.1 - 0.072 12.9 0.7 11 5.7 0.1 2.6 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain zf_UBZ PF18439.1 CDF39824.1 - 0.075 12.6 9.8 3.6 7.3 0.1 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Sgf11 PF08209.11 CDF39824.1 - 0.27 10.8 0.1 0.27 10.8 0.1 3.4 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) TRAF6_Z2 PF18048.1 CDF39824.1 - 0.29 11.3 2.1 2.2 8.5 0.1 2.7 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 zf-Di19 PF05605.12 CDF39824.1 - 0.38 11.1 12.4 3.3 8.1 0.4 3.6 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-U11-48K PF05253.12 CDF39824.1 - 1.5 8.9 5.3 4.4 7.3 0.1 3.4 3 0 0 3 3 3 0 U11-48K-like CHHC zinc finger zf-C3HC4_3 PF13920.6 CDF39824.1 - 1.8 8.5 9.7 19 5.2 0.1 4.1 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.6 CDF39824.1 - 8.4 6.0 9.2 1.6 8.3 0.1 3.5 4 0 0 4 4 4 0 zinc-ribbon domain Utp12 PF04003.12 CDF39826.1 - 2.8e-16 59.8 0.6 3.8e-16 59.3 0.6 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF4485 PF14846.6 CDF39826.1 - 0.082 13.0 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) Nop14 PF04147.12 CDF39826.1 - 1.1 7.4 17.9 0.036 12.3 6.2 2.2 2 0 0 2 2 2 0 Nop14-like family BUD22 PF09073.10 CDF39826.1 - 2.6 7.3 21.6 0.3 10.4 8.9 2.1 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.12 CDF39826.1 - 3.5 7.3 19.6 0.22 11.2 6.5 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ephrin_rec_like PF07699.13 CDF39828.1 - 1.3 8.8 9.2 1.5 8.7 0.1 3.5 4 0 0 4 4 4 0 Putative ephrin-receptor like dCMP_cyt_deam_1 PF00383.23 CDF39828.1 - 3.6 7.5 5.8 40 4.2 0.3 3.3 3 0 0 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region Transketolase_N PF00456.21 CDF39832.1 - 1.6e-151 504.0 0.0 2.1e-151 503.6 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CDF39832.1 - 1.9e-39 135.2 0.0 3.7e-39 134.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDF39832.1 - 5e-08 32.9 0.0 1.4e-07 31.4 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CDF39832.1 - 0.0016 17.7 0.0 0.099 11.8 0.0 2.2 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CDF39832.1 - 0.065 12.2 0.2 0.099 11.6 0.2 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component XFP_C PF09363.10 CDF39832.1 - 0.088 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 XFP C-terminal domain HEAT PF02985.22 CDF39833.1 - 6.1e-11 41.6 5.3 0.0031 17.6 0.3 3.9 3 0 0 3 3 3 3 HEAT repeat Arm PF00514.23 CDF39833.1 - 5.1e-09 35.9 0.5 0.00012 22.0 0.1 3.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CDF39833.1 - 1.9e-08 34.6 11.4 7.4e-07 29.5 3.4 3.0 2 2 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 CDF39833.1 - 3.9e-08 33.6 9.5 0.00038 20.9 2.1 3.7 2 1 2 4 4 4 3 HEAT-like repeat SIL1 PF16782.5 CDF39833.1 - 0.00032 20.0 0.0 0.00063 19.0 0.0 1.4 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 Fes1 PF08609.10 CDF39833.1 - 0.0018 19.1 0.1 0.0094 16.8 0.0 2.0 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 Atx10homo_assoc PF09759.9 CDF39833.1 - 0.031 14.3 0.0 0.14 12.2 0.0 1.9 1 1 1 2 2 2 0 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 CDF39833.1 - 0.041 13.9 0.0 0.097 12.7 0.0 1.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.6 CDF39833.1 - 0.05 14.0 0.7 6.1 7.3 0.0 3.3 2 1 2 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Adaptin_N PF01602.20 CDF39833.1 - 0.07 11.7 0.1 0.1 11.2 0.1 1.3 1 0 0 1 1 1 0 Adaptin N terminal region HEAT_PBS PF03130.16 CDF39833.1 - 0.38 11.5 0.2 0.38 11.5 0.2 4.3 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat DEAD PF00270.29 CDF39835.1 - 9.1e-39 133.0 0.0 1.2e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF39835.1 - 1.8e-29 102.3 0.2 1e-28 99.9 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF39835.1 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDF39835.1 - 0.0024 17.1 0.1 0.004 16.4 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Amidase PF01425.21 CDF39836.1 - 1.2e-144 482.6 1.8 1.4e-144 482.5 1.8 1.0 1 0 0 1 1 1 1 Amidase Myelin_MBP PF01669.17 CDF39837.1 - 0.026 15.1 0.0 0.029 15.0 0.0 1.1 1 0 0 1 1 1 0 Myelin basic protein Aminotran_1_2 PF00155.21 CDF39840.1 - 2.8e-48 164.9 0.0 3.3e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDF39840.1 - 3.6e-06 26.5 0.4 8.2e-06 25.3 0.4 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CDF39840.1 - 0.0033 16.8 0.3 0.0061 15.9 0.3 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDF39840.1 - 0.0044 16.0 0.0 0.0075 15.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 CDF39840.1 - 0.0051 15.6 0.1 0.015 14.0 0.1 1.6 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain EB PF01683.18 CDF39841.1 - 8.6e-06 25.9 24.6 0.028 14.7 7.3 3.8 2 2 2 4 4 4 3 EB module amfpi-1 PF12190.8 CDF39841.1 - 1.2e-05 25.8 17.2 0.11 13.1 2.1 4.1 3 2 1 4 4 4 3 Fungal protease inhibitor SLC3A2_N PF16028.5 CDF39841.1 - 0.042 13.4 0.0 15 5.2 0.0 3.1 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus Dickkopf_N PF04706.12 CDF39841.1 - 0.17 12.4 30.9 0.4 11.2 9.4 3.5 2 1 0 3 3 3 0 Dickkopf N-terminal cysteine-rich region Stig1 PF04885.13 CDF39841.1 - 0.24 11.9 30.5 1.1 9.7 4.5 2.1 1 1 1 2 2 2 0 Stigma-specific protein, Stig1 IGFBP PF00219.18 CDF39841.1 - 3 8.6 29.1 6.3 7.5 1.0 4.4 4 1 0 4 4 4 0 Insulin-like growth factor binding protein Retrotran_gag_2 PF14223.6 CDF39842.1 - 4.7e-34 117.0 0.9 7.4e-34 116.4 0.9 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF39842.1 - 4.3e-22 78.5 0.0 1.5e-21 76.8 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF39842.1 - 0.00011 22.0 0.0 0.00036 20.3 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF39842.1 - 0.00043 20.0 0.0 0.0013 18.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CDF39842.1 - 0.4 10.8 3.9 0.82 9.9 3.9 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF39842.1 - 0.68 9.7 3.5 1.3 8.8 2.2 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDF39842.1 - 1.1 9.1 5.9 3.2 7.7 5.9 1.7 1 0 0 1 1 1 0 Zinc knuckle tRNA-synt_2 PF00152.20 CDF39843.1 - 0.1 11.7 0.0 0.11 11.6 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Metalloenzyme PF01676.18 CDF39844.1 - 3.7e-37 128.0 0.0 4.1e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CDF39844.1 - 9e-23 80.9 1.2 1.4e-22 80.2 0.1 1.7 2 0 0 2 2 2 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 CDF39844.1 - 0.00081 19.1 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PIG-L PF02585.17 CDF39844.1 - 0.073 13.7 0.0 0.12 13.0 0.0 1.4 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase Glyco_hydro_4 PF02056.16 CDF39844.1 - 0.1 12.1 0.1 0.24 10.9 0.1 1.5 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Sulfotransfer_3 PF13469.6 CDF39845.1 - 0.0097 16.3 1.4 0.96 9.8 1.4 2.5 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 CDF39845.1 - 0.021 14.3 0.1 0.033 13.6 0.1 1.5 1 0 0 1 1 1 0 Sulfotransferase domain Herpes_LMP1 PF05297.11 CDF39845.1 - 0.076 12.2 1.3 0.13 11.5 1.3 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Transglut_core PF01841.19 CDF39846.1 - 4e-13 49.8 0.8 9.6e-13 48.6 0.8 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.15 CDF39846.1 - 1.6e-05 24.6 0.0 3.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain HscB_4_cys PF18256.1 CDF39846.1 - 1.2 9.0 4.0 0.3 10.9 0.3 2.0 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif Ribosomal_L4 PF00573.22 CDF39847.1 - 1.2e-41 142.5 0.0 1.7e-41 142.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 CDF39847.1 - 1.2e-24 86.1 2.3 1.2e-24 86.1 2.3 1.7 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain GalKase_gal_bdg PF10509.9 CDF39848.1 - 4.9e-19 67.6 0.0 9.3e-19 66.7 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 CDF39848.1 - 2.6e-12 46.8 0.5 7e-12 45.4 0.1 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CDF39848.1 - 9.9e-12 45.1 0.0 2e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal DUF596 PF04591.12 CDF39848.1 - 0.15 12.2 0.0 7.6 6.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function, DUF596 TIP49 PF06068.13 CDF39850.1 - 5.3e-72 243.0 3.1 1.7e-43 149.2 0.0 2.0 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 CDF39850.1 - 6e-09 35.9 0.1 2.9e-08 33.7 0.1 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain HA2 PF04408.23 CDF39852.1 - 2.4e-11 43.9 0.1 9.2e-11 42.0 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDF39852.1 - 5.3e-11 42.9 0.0 9.9e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF39852.1 - 4.7e-06 26.5 0.0 9.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDF39852.1 - 0.00014 22.2 0.1 0.00034 20.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDF39852.1 - 0.015 14.3 0.0 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 CDF39852.1 - 0.023 14.1 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 CDF39852.1 - 0.027 14.8 0.0 0.093 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain DUF364 PF04016.12 CDF39852.1 - 0.041 13.5 0.1 0.65 9.6 0.0 2.6 3 0 0 3 3 3 0 Putative heavy-metal chelation AAA_30 PF13604.6 CDF39852.1 - 0.045 13.5 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDF39852.1 - 0.15 12.4 0.4 1.6 9.1 0.1 2.6 3 1 0 3 3 3 0 AAA ATPase domain EF-hand_7 PF13499.6 CDF39853.1 - 5.3e-19 68.4 1.1 1.7e-12 47.6 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 CDF39853.1 - 3.7e-16 57.4 1.3 0.00012 21.4 0.4 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDF39853.1 - 8.8e-16 56.4 0.9 3e-05 23.6 0.2 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 CDF39853.1 - 1.1e-15 56.3 1.6 7.5e-05 22.1 0.0 3.5 3 0 0 3 3 3 3 EF hand Dockerin_1 PF00404.18 CDF39853.1 - 2.5e-08 34.0 3.9 1.6e-05 25.0 0.6 2.3 1 1 1 2 2 2 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 CDF39853.1 - 1.8e-06 28.2 0.0 0.00028 21.2 0.0 2.3 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 CDF39853.1 - 5.2e-06 26.2 0.7 0.00056 19.7 0.1 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 CDF39853.1 - 0.035 14.1 0.6 3.2 7.7 0.0 3.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand FlbD PF06289.11 CDF39853.1 - 0.22 11.2 1.0 0.31 10.7 0.2 1.6 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins CRM1_repeat_2 PF18784.1 CDF39854.1 - 0.047 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 CRM1 / Exportin repeat 2 Hemerythrin PF01814.23 CDF39854.1 - 0.099 13.3 0.7 1.3 9.7 0.1 2.3 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain Brix PF04427.18 CDF39855.1 - 4.1e-20 72.7 0.0 5.3e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Brix domain Arm PF00514.23 CDF39856.1 - 9.1e-87 282.8 16.8 1.8e-11 43.7 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDF39856.1 - 7.9e-27 93.3 2.4 5.2e-08 33.2 0.0 6.8 6 1 1 7 7 7 5 HEAT-like repeat HEAT_2 PF13646.6 CDF39856.1 - 6.6e-21 74.5 0.0 2.4e-08 34.2 0.0 5.4 2 1 4 6 6 6 5 HEAT repeats IBB PF01749.20 CDF39856.1 - 9e-20 70.9 1.8 2.2e-19 69.7 1.8 1.7 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 CDF39856.1 - 2.8e-18 65.2 0.0 1.8e-17 62.7 0.1 2.2 2 0 0 2 2 2 1 Atypical Arm repeat HEAT PF02985.22 CDF39856.1 - 3.2e-18 64.3 1.0 0.00011 22.2 0.0 7.0 7 0 0 7 7 7 3 HEAT repeat V-ATPase_H_C PF11698.8 CDF39856.1 - 1.3e-07 31.7 0.0 0.18 11.9 0.0 4.4 4 1 0 4 4 4 1 V-ATPase subunit H Arm_2 PF04826.13 CDF39856.1 - 2.5e-07 30.4 0.6 0.017 14.6 0.7 3.4 2 1 1 3 3 3 2 Armadillo-like Adaptin_N PF01602.20 CDF39856.1 - 3.1e-06 26.0 0.0 0.026 13.1 0.0 2.1 1 1 1 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 CDF39856.1 - 6.6e-06 26.3 0.0 2.6 8.1 0.0 3.7 1 1 3 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Atx10homo_assoc PF09759.9 CDF39856.1 - 2.3e-05 24.3 0.1 0.22 11.6 0.0 3.4 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain RICTOR_V PF14668.6 CDF39856.1 - 0.00016 21.9 0.1 1.6 9.1 0.0 4.7 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 CTNNBL PF08216.11 CDF39856.1 - 0.00025 21.2 0.3 0.11 12.7 0.0 3.8 4 0 0 4 4 3 1 Catenin-beta-like, Arm-motif containing nuclear Mo25 PF08569.11 CDF39856.1 - 0.0036 16.7 0.0 3.5 6.9 0.0 2.4 1 1 0 2 2 2 2 Mo25-like HEAT_PBS PF03130.16 CDF39856.1 - 0.011 16.3 0.4 2.3 9.1 0.0 4.3 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat DUF1902 PF08972.11 CDF39856.1 - 0.055 13.5 0.1 0.99 9.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) DUF3361 PF11841.8 CDF39856.1 - 0.068 13.1 0.2 3.7 7.5 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) NUDE_C PF04880.13 CDF39856.1 - 0.099 13.1 0.3 0.21 12.1 0.3 1.4 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region CLASP_N PF12348.8 CDF39856.1 - 0.11 12.1 0.1 8.7 5.8 0.1 2.9 3 1 0 3 3 3 0 CLASP N terminal Fe_dep_repr_C PF02742.15 CDF39856.1 - 0.32 11.1 1.0 19 5.4 0.1 3.3 3 0 0 3 3 3 0 Iron dependent repressor, metal binding and dimerisation domain FUSC_2 PF13515.6 CDF39857.1 - 2.7e-05 24.3 6.6 5.9e-05 23.2 6.6 1.6 1 0 0 1 1 1 1 Fusaric acid resistance protein-like ALMT PF11744.8 CDF39857.1 - 0.33 9.7 7.6 1.1 8.0 7.6 1.8 1 1 0 1 1 1 0 Aluminium activated malate transporter Plant_tran PF04827.14 CDF39859.1 - 8.3e-79 263.9 0.0 1.2e-78 263.5 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF39859.1 - 1.5e-15 57.2 0.0 2.7e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_tranf_2_3 PF13641.6 CDF39859.1 - 0.031 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DoxX_2 PF13564.6 CDF39860.1 - 1.4e-07 31.6 2.1 1.8e-07 31.2 2.1 1.3 1 0 0 1 1 1 1 DoxX-like family Ribosomal_L32e PF01655.18 CDF39862.1 - 1.2e-49 167.2 1.0 1.9e-49 166.6 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L32 Myb_DNA-bind_7 PF15963.5 CDF39863.1 - 1.1e-25 89.3 0.8 1.1e-25 89.3 0.8 1.6 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 CDF39863.1 - 5.2e-05 23.4 0.0 9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain APCDDC PF14921.6 CDF39863.1 - 0.0072 15.8 0.0 0.0093 15.4 0.0 1.1 1 0 0 1 1 1 1 Adenomatosis polyposis coli down-regulated 1 FAS_I_H PF18314.1 CDF39863.1 - 0.034 13.8 0.1 0.3 10.7 0.0 2.1 2 0 0 2 2 2 0 Fatty acid synthase type I helical domain AC_N PF16214.5 CDF39863.1 - 1 8.4 7.8 1.6 7.8 7.8 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DDRGK PF09756.9 CDF39863.1 - 1.8 8.1 9.4 0.1 12.2 3.9 1.7 2 0 0 2 2 2 0 DDRGK domain IF4E PF01652.18 CDF39864.1 - 1.8e-45 154.6 0.5 2.1e-45 154.3 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E BCDHK_Adom3 PF10436.9 CDF39865.1 - 1.8e-33 115.7 0.4 2.8e-33 115.1 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CDF39865.1 - 2.6e-08 34.4 0.0 2.5e-07 31.2 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDF39865.1 - 0.0022 17.9 0.0 0.0098 15.7 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CaATP_NAI PF12515.8 CDF39865.1 - 0.16 11.6 2.4 0.5 10.0 2.4 1.8 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Chorismate_bind PF00425.18 CDF39868.1 - 2.3e-86 289.5 0.0 4e-86 288.8 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 CDF39868.1 - 6.2e-34 117.4 0.0 1e-33 116.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 CDF39868.1 - 4.7e-17 62.5 0.1 4.2e-16 59.4 0.0 2.4 3 0 0 3 3 3 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 CDF39868.1 - 2.4e-05 24.2 0.4 0.00013 21.8 0.4 2.0 1 1 0 1 1 1 1 Peptidase C26 DUF5352 PF17303.2 CDF39868.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5352) ABC_membrane_2 PF06472.15 CDF39869.1 - 5.2e-57 193.3 2.8 6.7e-57 192.9 2.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDF39869.1 - 4.1e-16 59.7 0.0 9.5e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SbmA_BacA PF05992.12 CDF39869.1 - 4e-10 39.7 3.1 1.2e-09 38.1 3.1 1.7 1 1 0 1 1 1 1 SbmA/BacA-like family ABC_membrane PF00664.23 CDF39869.1 - 5e-06 26.4 3.9 8.3e-06 25.6 3.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_30 PF13604.6 CDF39869.1 - 0.0003 20.6 0.0 0.027 14.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDF39869.1 - 0.0014 19.1 0.2 0.0054 17.1 0.1 2.1 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 CDF39869.1 - 0.0024 17.8 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_29 PF13555.6 CDF39869.1 - 0.003 17.2 0.1 0.0072 16.1 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDF39869.1 - 0.0075 16.2 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 CDF39869.1 - 0.0087 15.9 0.2 0.025 14.4 0.2 1.8 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CDF39869.1 - 0.05 13.2 0.2 0.58 9.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CDF39869.1 - 0.055 13.9 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDF39869.1 - 0.089 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CDF39869.1 - 0.13 12.8 0.0 0.48 11.0 0.0 1.9 2 1 0 2 2 1 0 AAA domain AAA_22 PF13401.6 CDF39869.1 - 0.16 12.3 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CDF39869.1 - 0.16 11.0 0.1 0.27 10.2 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CDF39869.1 - 0.17 12.0 0.0 0.67 10.1 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDF39870.1 - 1e-52 178.6 0.0 1.6e-52 177.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CDF39870.1 - 2e-45 153.3 5.3 4e-45 152.4 5.3 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CDF39870.1 - 8.7e-23 80.2 0.0 2.2e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF39870.1 - 5.1e-13 49.2 2.5 1.1e-12 48.1 2.5 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF39870.1 - 4.3e-06 26.8 0.0 1.1e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDF39870.1 - 0.00045 20.2 0.1 0.0021 18.1 0.1 2.1 1 1 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 CDF39870.1 - 0.0006 19.6 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1_Xtn PF16897.5 CDF39870.1 - 0.048 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain polyprenyl_synt PF00348.17 CDF39872.1 - 4.4e-58 196.3 0.0 5.2e-58 196.1 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase UFD1 PF03152.14 CDF39873.1 - 3.4e-56 189.4 0.0 4.2e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 VCBS PF13517.6 CDF39875.1 - 1.1e-18 67.5 25.5 9.8e-06 26.1 0.3 6.5 2 2 5 7 7 7 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDF39875.1 - 0.00057 20.0 18.3 1.3 9.3 0.7 6.2 6 0 0 6 6 6 4 FG-GAP repeat ABC_tran PF00005.27 CDF39876.1 - 6e-43 146.7 0.1 4.2e-26 92.1 0.0 2.5 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDF39876.1 - 4.5e-16 58.6 2.6 2.4e-13 49.9 1.9 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDF39876.1 - 5.7e-12 46.1 7.9 5.7e-06 26.4 0.1 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF39876.1 - 9e-06 25.3 7.9 0.27 10.6 0.7 4.0 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDF39876.1 - 0.00039 20.1 0.7 0.58 9.9 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF39876.1 - 0.0043 17.5 0.5 3.2 8.1 0.2 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CDF39876.1 - 0.0083 16.6 4.3 0.54 10.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 CDF39876.1 - 0.046 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Bac_A_amyl_C PF18612.1 CDF39876.1 - 0.11 12.2 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain AAA_15 PF13175.6 CDF39876.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 CDF39876.1 - 0.16 12.2 0.0 0.74 10.0 0.0 2.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 CDF39876.1 - 0.17 12.2 0.3 3.9 7.7 0.1 2.8 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CDF39876.1 - 0.19 11.7 0.2 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Dynamin family IIGP PF05049.13 CDF39876.1 - 0.2 10.7 0.1 0.39 9.7 0.1 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) SF3b10 PF07189.11 CDF39877.1 - 3.9e-31 107.0 0.0 7.2e-31 106.1 0.0 1.4 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) SF3b10 PF07189.11 CDF39881.1 - 5.5e-32 109.7 0.0 7.4e-32 109.3 0.0 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) CBFD_NFYB_HMF PF00808.23 CDF39882.1 - 1.6e-22 79.5 1.0 1.6e-22 79.5 1.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDF39882.1 - 1.1e-18 67.9 4.5 1.7e-18 67.3 4.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 BACK PF07707.15 CDF39882.1 - 0.018 15.1 0.4 0.032 14.3 0.4 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch TAF PF02969.17 CDF39882.1 - 0.053 13.7 2.2 0.059 13.6 0.7 1.8 2 0 0 2 2 2 0 TATA box binding protein associated factor (TAF) CENP-X PF09415.10 CDF39882.1 - 0.092 13.1 0.3 0.16 12.3 0.3 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Peptidase_M26_N PF05342.14 CDF39882.1 - 0.12 11.7 0.1 0.17 11.3 0.1 1.1 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase N-terminal region SNF2_N PF00176.23 CDF39883.1 - 6.6e-69 232.3 0.3 1.4e-68 231.2 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF39883.1 - 1.4e-19 70.4 0.1 1.4e-19 70.4 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CDF39883.1 - 1.8e-08 33.9 0.2 1.8e-08 33.9 0.2 2.3 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 CDF39883.1 - 2e-07 31.2 0.1 1.9e-06 28.0 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2730 PF10805.8 CDF39883.1 - 0.11 12.6 1.2 0.39 10.8 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) RNA_pol_Rpb1_5 PF04998.17 CDF39885.1 - 1e-80 271.0 0.3 1.6e-80 270.4 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 CDF39885.1 - 1.3e-76 258.0 0.0 2e-76 257.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CDF39885.1 - 1.1e-75 253.4 0.0 2.5e-75 252.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CDF39885.1 - 5.1e-36 124.0 0.0 1.3e-35 122.7 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CDF39885.1 - 4.4e-24 84.5 0.0 9.5e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 zinc_ribbon_10 PF10058.9 CDF39885.1 - 0.14 11.9 0.6 16 5.3 0.1 2.7 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein RRM_1 PF00076.22 CDF39886.1 - 3.3e-84 276.7 0.6 1.2e-20 73.1 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CDF39886.1 - 7.5e-27 93.3 1.3 1.5e-26 92.4 1.3 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 CDF39886.1 - 3.5e-10 39.5 0.0 0.00012 21.7 0.0 3.9 1 1 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDF39886.1 - 5.5e-06 26.3 0.1 0.095 12.7 0.0 4.0 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CDF39886.1 - 2.5e-05 24.3 0.5 0.92 9.6 0.0 4.1 4 0 0 4 4 4 2 RNA binding motif RRM_occluded PF16842.5 CDF39886.1 - 4.5e-05 23.2 0.0 0.68 9.8 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CDF39886.1 - 0.00018 21.5 0.1 0.0082 16.2 0.1 3.1 3 0 0 3 3 3 1 Limkain b1 RRM_7 PF16367.5 CDF39886.1 - 0.0015 18.6 0.0 13 6.0 0.0 4.4 4 1 0 4 4 4 1 RNA recognition motif PHM7_cyt PF14703.6 CDF39886.1 - 0.0042 17.3 0.3 4.1 7.6 0.1 4.2 2 2 1 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter SET_assoc PF11767.8 CDF39886.1 - 0.044 13.4 0.0 62 3.3 0.0 3.8 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated Homoserine_dh PF00742.19 CDF39888.1 - 3.4e-51 173.6 0.0 5.9e-51 172.8 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase AA_kinase PF00696.28 CDF39888.1 - 4.7e-35 121.3 1.1 6.3e-35 120.9 0.1 1.8 2 0 0 2 2 2 1 Amino acid kinase family NAD_binding_3 PF03447.16 CDF39888.1 - 1.9e-20 73.7 0.0 8.4e-20 71.6 0.0 2.2 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain ACT_7 PF13840.6 CDF39888.1 - 4.7e-13 48.7 2.8 1.4e-05 24.8 0.7 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CDF39888.1 - 6e-12 45.1 0.7 2.7e-06 27.1 0.1 2.9 2 0 0 2 2 2 2 ACT domain Dehydratase_MU PF02288.15 CDF39888.1 - 0.014 15.3 0.0 4.2 7.3 0.0 2.6 2 0 0 2 2 2 0 Dehydratase medium subunit ACT_6 PF13740.6 CDF39888.1 - 0.029 14.4 0.5 0.12 12.4 0.1 2.2 2 0 0 2 2 2 0 ACT domain Pyr_redox_2 PF07992.14 CDF39889.1 - 7.9e-49 166.5 5.9 1.2e-48 165.9 5.9 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF39889.1 - 9.3e-15 55.0 1.6 1.7e-11 44.5 0.1 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDF39889.1 - 2.4e-08 33.6 0.4 1.9e-05 24.1 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDF39889.1 - 1.8e-05 25.1 2.1 0.0012 19.2 0.2 2.8 3 0 0 3 3 3 1 Putative NAD(P)-binding GIDA PF01134.22 CDF39889.1 - 0.00016 20.9 3.6 0.0037 16.4 0.1 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CDF39889.1 - 0.0089 15.4 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.14 CDF39889.1 - 0.011 14.5 4.6 3.8 6.1 0.3 3.1 3 0 0 3 3 3 0 HI0933-like protein 3HCDH_N PF02737.18 CDF39889.1 - 0.014 15.3 0.7 0.042 13.7 0.1 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CDF39889.1 - 0.023 14.0 1.3 0.34 10.2 0.3 2.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 CDF39889.1 - 0.031 14.4 0.2 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 CDF39889.1 - 0.037 13.6 7.1 1.6 8.2 0.0 3.2 2 1 1 3 3 3 0 FAD dependent oxidoreductase PALP PF00291.25 CDF39889.1 - 0.044 13.2 1.2 0.11 11.9 0.1 2.1 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme Lycopene_cycl PF05834.12 CDF39889.1 - 0.16 11.0 3.5 19 4.2 0.1 3.4 4 0 0 4 4 4 0 Lycopene cyclase protein K_oxygenase PF13434.6 CDF39889.1 - 0.2 10.7 0.1 0.62 9.1 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 CDF39889.1 - 0.85 8.6 8.9 7.6 5.5 0.1 3.7 4 0 0 4 4 4 0 FAD binding domain FAD_oxidored PF12831.7 CDF39889.1 - 4.5 6.5 8.8 3.4 6.9 1.1 3.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase PIF1 PF05970.14 CDF39890.1 - 3.5e-98 329.1 0.0 5.1e-98 328.6 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF39890.1 - 2.8e-47 161.4 0.0 4.8e-47 160.7 0.0 1.3 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF39890.1 - 4.7e-12 46.0 0.0 8.3e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF39890.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain RVT_2 PF07727.14 CDF39891.1 - 2.8e-66 223.6 0.1 5.6e-66 222.6 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF39891.1 - 6.4e-33 113.3 1.3 9.2e-33 112.8 0.1 2.0 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type gag_pre-integrs PF13976.6 CDF39891.1 - 7.1e-08 32.2 0.0 3.7e-07 29.9 0.0 2.3 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CDF39891.1 - 1.2e-06 28.7 1.2 0.17 12.0 0.0 3.9 3 1 1 4 4 4 2 Integrase core domain rve_3 PF13683.6 CDF39891.1 - 0.025 14.3 0.0 0.071 12.9 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain CENP-C_mid PF15620.6 CDF39891.1 - 0.029 14.3 0.3 0.056 13.4 0.3 1.3 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region RVT_2 PF07727.14 CDF39892.1 - 1.5e-62 211.4 0.0 3e-62 210.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF39892.1 - 8.1e-33 113.0 1.3 1.1e-32 112.6 0.1 2.0 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF39892.1 - 2.8e-19 69.4 0.4 3e-18 66.1 0.0 2.5 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 CDF39892.1 - 0.0027 17.5 0.0 0.007 16.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF39892.1 - 0.0032 17.3 0.2 0.018 14.9 0.1 2.3 2 0 0 2 2 2 1 GAG-pre-integrase domain zf-CCHC_4 PF14392.6 CDF39892.1 - 0.33 10.7 2.6 1 9.2 2.6 1.9 1 0 0 1 1 1 0 Zinc knuckle RVT_2 PF07727.14 CDF39893.1 - 2.6e-63 213.9 0.0 5e-63 213.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF39893.1 - 4.6e-33 113.8 0.1 9.9e-33 112.7 0.1 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type gag_pre-integrs PF13976.6 CDF39893.1 - 5.2e-07 29.4 0.0 2.4e-06 27.3 0.0 2.2 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CDF39893.1 - 0.0043 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF39893.1 - 0.018 14.8 0.0 0.044 13.6 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain RVT_2 PF07727.14 CDF39894.1 - 2.5e-60 204.1 0.0 4.7e-60 203.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF39894.1 - 7e-33 113.2 1.3 1e-32 112.7 0.1 2.0 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF39894.1 - 9e-13 48.5 0.4 9.4e-09 35.5 0.0 3.5 2 1 1 3 3 3 2 Integrase core domain gag_pre-integrs PF13976.6 CDF39894.1 - 9.3e-08 31.8 0.0 4.1e-07 29.8 0.0 2.2 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF39894.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain CENP-C_mid PF15620.6 CDF39894.1 - 0.033 14.2 0.1 0.06 13.3 0.1 1.3 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region RVT_2 PF07727.14 CDF39895.1 - 2.9e-06 27.1 0.0 3.7e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 CDF39896.1 - 1.3e-42 146.1 0.0 5.2e-31 108.1 0.0 2.7 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CDF39896.1 - 5.2e-21 75.0 0.0 2.2e-20 73.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF39896.1 - 0.00033 20.4 0.0 0.00092 18.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CDF39897.1 - 8.4e-60 202.4 0.1 1.6e-59 201.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF39897.1 - 2e-07 30.8 0.0 4.2e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF39897.1 - 5.6e-06 26.5 0.1 0.15 12.2 0.0 2.8 1 1 1 2 2 2 2 Integrase core domain rve_3 PF13683.6 CDF39897.1 - 0.031 14.0 0.0 0.079 12.8 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain gag_pre-integrs PF13976.6 CDF39897.1 - 0.2 11.6 3.5 0.088 12.7 0.3 2.2 2 0 0 2 2 2 0 GAG-pre-integrase domain zf-CCHC_4 PF14392.6 CDF39897.1 - 0.26 11.0 1.8 0.78 9.5 1.8 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF39897.1 - 0.74 10.0 4.1 1.8 8.8 4.1 1.7 1 0 0 1 1 1 0 Zinc knuckle PIF1 PF05970.14 CDF39898.1 - 6.9e-74 249.2 0.0 9.9e-74 248.7 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF39898.1 - 1.6e-52 178.5 0.0 2.6e-52 177.8 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF39898.1 - 0.0052 16.5 0.0 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_UL16 PF03044.14 CDF39898.1 - 0.041 13.2 2.0 0.34 10.2 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus UL16/UL94 family HAD_2 PF13419.6 CDF39900.1 - 2.8e-22 79.6 0.0 3.4e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF39900.1 - 1.6e-13 51.5 0.0 1.8e-09 38.2 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF39900.1 - 1.3e-06 29.0 0.0 1.5e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDF39900.1 - 4.5e-05 23.4 0.0 7.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDF39900.1 - 0.056 13.6 0.0 4.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Acyltransferase PF01553.21 CDF39901.1 - 1.3e-17 63.7 0.0 2e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Peptidase_S49 PF01343.18 CDF39902.1 - 2.6e-57 193.1 0.0 8.2e-39 133.0 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 CLP_protease PF00574.23 CDF39902.1 - 3.3e-07 30.4 0.8 0.00055 19.9 0.1 3.3 3 0 0 3 3 3 1 Clp protease SDH_sah PF01972.16 CDF39902.1 - 0.0056 15.7 0.2 0.011 14.8 0.2 1.4 1 0 0 1 1 1 1 Serine dehydrogenase proteinase ECH_1 PF00378.20 CDF39902.1 - 0.041 13.2 6.8 2.7 7.2 0.2 4.4 4 1 1 5 5 5 0 Enoyl-CoA hydratase/isomerase Lactamase_B_6 PF16661.5 CDF39903.1 - 9.3e-24 83.9 0.0 1.5e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 CDF39903.1 - 8.6e-15 55.0 0.0 1.8e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 CDF39903.1 - 2.3e-12 47.4 0.5 3.7e-11 43.4 0.5 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF39903.1 - 1e-11 44.8 0.1 4.7e-10 39.3 0.0 2.7 2 1 1 3 3 3 1 Beta-lactamase superfamily domain RMMBL PF07521.12 CDF39903.1 - 2.9e-08 33.5 0.0 6.8e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 CDF39903.1 - 0.0014 18.5 0.0 0.0044 16.9 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Ammonium_transp PF00909.21 CDF39904.1 - 8.4e-109 363.9 36.5 9.1e-106 353.9 36.5 2.0 1 1 0 1 1 1 1 Ammonium Transporter Family Baculo_11_kDa PF06143.11 CDF39904.1 - 0.53 9.9 5.2 1.8 8.2 0.1 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family IBV_3C PF03620.13 CDF39904.1 - 0.87 10.1 5.6 1.6 9.2 0.6 3.3 2 1 1 3 3 3 0 IBV 3C protein RT_RNaseH_2 PF17919.1 CDF39905.1 - 2.6e-32 110.8 0.0 5.8e-32 109.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF39905.1 - 1.1e-31 109.2 0.0 3.3e-31 107.7 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF39905.1 - 5.2e-15 55.3 0.1 1e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF39905.1 - 3.5e-10 39.6 0.0 7.2e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 CDF39905.1 - 7.7e-05 22.9 0.1 0.00077 19.6 0.2 2.3 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 CDF39905.1 - 0.003 17.3 1.4 0.0096 15.7 0.2 2.5 3 0 0 3 3 3 1 Integrase core domain zf-H2C2 PF09337.10 CDF39905.1 - 0.0081 16.4 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger FGAR-AT_linker PF18072.1 CDF39905.1 - 0.021 15.4 0.0 4.5 7.9 0.0 3.2 3 0 0 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain Plant_tran PF04827.14 CDF39906.1 - 6.2e-35 120.7 0.0 5.8e-31 107.7 0.0 2.4 1 1 1 2 2 2 2 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF39906.1 - 3.7e-05 23.5 0.0 6.1e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CDF39906.1 - 0.008 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain E1_4HB PF16191.5 CDF39907.1 - 0.13 12.5 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle ThiF PF00899.21 CDF39908.1 - 5.1e-97 324.0 0.0 9.4e-69 231.5 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 CDF39908.1 - 2e-89 299.9 0.1 2.9e-89 299.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 CDF39908.1 - 2.3e-31 108.3 0.0 4.8e-31 107.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 CDF39908.1 - 3.4e-30 104.0 0.0 8.8e-30 102.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 CDF39908.1 - 6.9e-13 48.6 0.0 4.9e-11 42.6 0.0 2.7 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle Complex1_LYR_2 PF13233.6 CDF39908.1 - 0.18 12.6 0.0 0.44 11.3 0.0 1.6 1 0 0 1 1 1 0 Complex1_LYR-like PBS_linker_poly PF00427.21 CDF39909.1 - 2e-32 111.9 0.1 3.3e-32 111.2 0.1 1.4 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide EIF_2_alpha PF07541.12 CDF39912.1 - 6.7e-39 132.6 0.0 1.3e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CDF39912.1 - 1.4e-11 44.6 0.4 2.7e-11 43.6 0.4 1.4 1 0 0 1 1 1 1 S1 RNA binding domain DUF4312 PF14189.6 CDF39912.1 - 0.0013 18.7 0.0 0.0039 17.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4312) Rdx PF10262.9 CDF39913.1 - 2.3e-26 91.8 0.0 3.1e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Rdx family zf-CCCH PF00642.24 CDF39916.1 - 4.4e-21 74.3 13.1 8.2e-11 41.5 4.3 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDF39916.1 - 2.3e-09 37.0 12.4 9.1e-05 22.4 0.9 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 CDF39916.1 - 4.7e-09 35.8 10.1 6.3e-05 22.7 1.3 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDF39916.1 - 5.3e-05 23.5 6.8 0.042 14.3 0.6 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CDF39916.1 - 1.2 9.9 12.9 0.69 10.6 1.4 2.7 2 1 1 3 3 3 0 Torus domain TP6A_N PF04406.14 CDF39919.1 - 1.5e-19 69.7 0.0 2.8e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase YlbE PF14003.6 CDF39919.1 - 0.035 14.5 0.0 0.068 13.6 0.0 1.4 1 0 0 1 1 1 0 YlbE-like protein UPF0051 PF01458.17 CDF39920.1 - 2e-57 194.4 0.5 2.6e-57 194.0 0.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) Myb_DNA-binding PF00249.31 CDF39922.1 - 1.5e-11 44.3 1.1 2.4e-11 43.6 1.1 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF39922.1 - 0.0061 16.8 0.3 0.013 15.8 0.3 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF39922.1 - 0.017 15.0 0.2 0.031 14.2 0.2 1.4 1 0 0 1 1 1 0 Myb DNA-binding like TFIIF_beta PF02270.15 CDF39924.1 - 7.6e-08 32.4 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Globin PF00042.22 CDF39925.1 - 2.1e-14 54.0 0.0 3.2e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Globin Protoglobin PF11563.8 CDF39925.1 - 0.0013 18.6 0.0 0.0024 17.8 0.0 1.4 1 1 0 1 1 1 1 Protoglobin Bac_globin PF01152.21 CDF39925.1 - 0.052 13.7 0.2 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial-like globin DUF3754 PF12576.8 CDF39926.1 - 0.00061 19.7 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) Radical_SAM PF04055.21 CDF39927.1 - 3.2e-16 60.1 0.0 5.1e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 CDF39927.1 - 2.5e-07 31.1 0.0 5.2e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family PTPA PF03095.15 CDF39928.1 - 3.4e-115 384.6 0.0 4e-115 384.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Fas_alpha_ACP PF18325.1 CDF39928.1 - 0.087 13.2 0.0 0.79 10.0 0.0 2.2 2 0 0 2 2 2 0 Fatty acid synthase subunit alpha Acyl carrier domain Asp PF00026.23 CDF39929.1 - 1.9e-38 132.7 0.0 3.4e-38 131.8 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 CDF39929.1 - 1.9e-10 40.7 0.0 3e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 CDF39929.1 - 0.00034 21.2 0.0 0.51 11.0 0.0 3.7 4 0 0 4 4 4 1 Aspartyl protease gag-asp_proteas PF13975.6 CDF39929.1 - 0.002 18.7 0.0 0.27 11.8 0.0 2.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease PSI PF01437.25 CDF39929.1 - 0.023 15.2 6.2 0.023 15.2 6.2 2.7 2 0 0 2 2 2 0 Plexin repeat SET PF00856.28 CDF39930.1 - 6e-10 39.8 0.0 4.6e-09 36.9 0.0 2.2 2 1 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 CDF39930.1 - 2.7e-08 34.5 0.4 4.9e-08 33.7 0.4 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Mt_ATP-synt_D PF05873.12 CDF39931.1 - 1.4e-07 31.5 1.9 1.9e-07 31.1 1.9 1.2 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) SnoaL_2 PF12680.7 CDF39937.1 - 0.0014 19.2 0.0 0.0024 18.5 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF4808 PF16066.5 CDF39937.1 - 0.11 13.0 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) RT_RNaseH PF17917.1 CDF39938.1 - 4.4e-34 116.9 0.2 7.9e-33 112.9 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF39938.1 - 3e-32 110.6 0.0 5e-32 109.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF39938.1 - 5.2e-05 22.9 0.0 0.00028 20.5 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAF PF15715.5 CDF39939.1 - 0.15 12.7 0.9 0.17 12.5 0.9 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain N2227 PF07942.12 CDF39940.1 - 5.1e-58 196.4 0.0 6.9e-58 196.0 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 CDF39940.1 - 0.087 13.5 0.0 0.24 12.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CDF39940.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DnaJ PF00226.31 CDF39941.1 - 5.6e-19 68.0 1.2 3.6e-18 65.4 0.0 2.4 2 0 0 2 2 2 1 DnaJ domain GIT_CC PF16559.5 CDF39941.1 - 0.69 9.8 3.0 1.2 9.1 2.8 1.4 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF5595 PF18077.1 CDF39941.1 - 1.7 8.8 7.5 7.4 6.7 1.5 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5595) FUSC PF04632.12 CDF39941.1 - 6.4 5.2 5.0 7.9 4.9 5.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GTP_EFTU PF00009.27 CDF39943.1 - 5e-36 124.1 0.0 8.5e-36 123.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CDF39943.1 - 5.9e-31 107.6 0.6 1e-30 106.8 0.6 1.3 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 CDF39943.1 - 2e-18 66.3 0.0 4.9e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CDF39943.1 - 5.8e-16 58.3 0.0 1.3e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF39943.1 - 1.7e-09 37.9 0.2 4.4e-09 36.6 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CDF39943.1 - 9.2e-07 28.9 0.0 2e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CDF39943.1 - 0.016 15.3 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Septin PF00735.18 CDF39943.1 - 0.036 13.3 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Septin Histone PF00125.24 CDF39944.1 - 4.2e-53 179.2 1.3 4.7e-53 179.0 1.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDF39944.1 - 5.7e-05 23.7 0.9 6.7e-05 23.5 0.9 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDF39944.1 - 0.00031 20.8 0.1 0.00062 19.9 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDF39944.1 - 0.00062 20.1 0.0 0.00095 19.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDF39944.1 - 0.0027 18.0 0.0 0.0051 17.1 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDF39944.1 - 0.025 14.7 0.2 0.044 13.8 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Exo_endo_phos PF03372.23 CDF39945.1 - 5.4e-10 39.2 0.1 9.4e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family C2 PF00168.30 CDF39945.1 - 8.2e-06 26.1 0.0 1.9e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain amfpi-1 PF12190.8 CDF39945.1 - 0.19 12.3 0.0 0.39 11.4 0.0 1.4 1 0 0 1 1 1 0 Fungal protease inhibitor DUF179 PF02622.15 CDF39947.1 - 4.6e-30 104.7 0.0 6e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Ribosomal_L22 PF00237.19 CDF39949.1 - 2.7e-20 72.5 0.5 4.6e-20 71.8 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Hc1 PF07432.13 CDF39949.1 - 0.1 13.0 0.3 0.16 12.3 0.3 1.3 1 0 0 1 1 1 0 Histone H1-like protein Hc1 HRCT1 PF15758.5 CDF39949.1 - 4.6 8.3 9.3 1.5 9.8 0.2 3.4 3 1 1 4 4 4 0 Histidine-rich carboxyl terminus protein 1 PAN_3 PF08277.12 CDF39950.1 - 0.0082 15.9 1.0 0.011 15.5 1.0 1.2 1 0 0 1 1 1 1 PAN-like domain Bunya_NS-S PF01104.17 CDF39950.1 - 0.37 10.6 4.9 0.13 12.1 0.7 1.9 2 0 0 2 2 2 0 Bunyavirus non-structural protein NS-s Prefoldin_2 PF01920.20 CDF39951.1 - 4e-17 62.1 14.0 4e-17 62.1 14.0 1.9 1 1 1 2 2 2 1 Prefoldin subunit Sugarporin_N PF11471.8 CDF39951.1 - 0.0053 16.7 0.2 0.011 15.7 0.2 1.5 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension AATF-Che1 PF13339.6 CDF39951.1 - 0.017 15.8 5.9 0.023 15.4 5.9 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor MRPL52 PF18699.1 CDF39951.1 - 0.034 14.3 15.0 0.3 11.3 0.8 2.4 1 1 0 2 2 2 0 Mitoribosomal protein mL52 LMBR1 PF04791.16 CDF39951.1 - 0.065 12.1 9.4 0.072 12.0 9.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Gp-FAR-1 PF05823.12 CDF39951.1 - 0.076 13.4 9.2 0.29 11.5 9.2 1.8 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF724 PF05266.14 CDF39951.1 - 0.13 12.1 9.0 0.15 11.8 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Prefoldin PF02996.17 CDF39951.1 - 0.44 10.5 14.4 1.6 8.7 0.6 2.6 1 1 2 3 3 3 0 Prefoldin subunit IL6 PF00489.17 CDF39951.1 - 0.45 10.1 7.1 0.18 11.3 0.9 2.0 2 0 0 2 2 2 0 Interleukin-6/G-CSF/MGF family Fzo_mitofusin PF04799.13 CDF39951.1 - 0.45 10.0 13.1 0.16 11.5 2.6 2.2 2 0 0 2 2 2 0 fzo-like conserved region Fib_alpha PF08702.10 CDF39951.1 - 0.83 9.8 15.4 0.25 11.5 2.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family RmuC PF02646.16 CDF39951.1 - 0.92 8.6 14.1 0.2 10.7 0.9 2.1 2 0 0 2 2 2 0 RmuC family VWA_N PF08399.11 CDF39951.1 - 1.5 9.4 6.4 0.46 11.0 1.6 2.0 2 0 0 2 2 2 0 VWA N-terminal YtxH PF12732.7 CDF39951.1 - 1.5 9.4 8.5 1.2e+02 3.3 8.5 2.6 1 1 0 1 1 1 0 YtxH-like protein OmpH PF03938.14 CDF39951.1 - 2.5 8.4 19.2 2.3 8.6 10.3 2.1 1 1 0 2 2 2 0 Outer membrane protein (OmpH-like) ABC_tran_CTD PF16326.5 CDF39951.1 - 7.2 6.9 11.6 0.19 12.0 1.3 2.5 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF4795 PF16043.5 CDF39951.1 - 7.4 6.1 16.4 1.7 8.2 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) UQ_con PF00179.26 CDF39952.1 - 1.2e-44 151.4 0.0 1.4e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TBCC PF07986.12 CDF39954.1 - 8.6e-19 67.4 1.5 1.5e-18 66.6 1.5 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 CDF39954.1 - 4e-05 23.3 0.7 6.9e-05 22.5 0.7 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal DEAD PF00270.29 CDF39955.1 - 1.3e-39 135.7 0.0 3.2e-39 134.5 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF39955.1 - 5.8e-22 78.1 0.0 3.4e-21 75.7 0.0 2.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF39955.1 - 0.012 15.6 0.0 0.043 13.8 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Hox9_act PF04617.13 CDF39956.1 - 0.064 14.0 0.0 0.07 13.9 0.0 1.1 1 0 0 1 1 1 0 Hox9 activation region DUF1077 PF06417.12 CDF39957.1 - 3e-23 82.1 0.6 4.5e-23 81.5 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) HEAT_2 PF13646.6 CDF39958.1 - 1.4e-08 35.0 3.1 0.1 13.0 0.0 4.6 3 1 0 4 4 4 4 HEAT repeats HEAT PF02985.22 CDF39958.1 - 5.1e-06 26.3 10.4 1.5 9.3 0.1 7.1 8 0 0 8 8 8 3 HEAT repeat HEAT_EZ PF13513.6 CDF39958.1 - 0.0029 18.1 0.6 15 6.2 0.0 5.4 6 1 0 6 6 6 1 HEAT-like repeat Arm PF00514.23 CDF39958.1 - 0.05 13.7 0.4 0.28 11.3 0.2 2.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CDF39960.1 - 1.3e-13 51.2 19.9 0.00012 22.3 0.4 7.1 5 2 2 7 7 7 5 HEAT repeats HEAT PF02985.22 CDF39960.1 - 4.6e-10 38.9 15.5 1.5 9.3 0.0 9.8 11 0 0 11 11 11 4 HEAT repeat Vac14_Fab1_bd PF12755.7 CDF39960.1 - 1.2e-05 25.8 2.2 8.1 7.1 0.0 5.9 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CDF39960.1 - 0.00038 20.5 9.9 2.2 8.3 0.1 5.0 4 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CDF39960.1 - 0.00058 20.3 10.0 6.5 7.4 0.0 6.6 7 1 0 7 7 7 2 HEAT-like repeat CLASP_N PF12348.8 CDF39960.1 - 0.00072 19.2 3.2 0.092 12.3 0.1 3.6 5 0 0 5 5 5 2 CLASP N terminal Adaptin_N PF01602.20 CDF39960.1 - 0.0077 14.8 6.0 0.86 8.1 0.1 4.0 3 1 0 3 3 3 1 Adaptin N terminal region DUF4042 PF13251.6 CDF39960.1 - 0.042 13.6 3.1 8.6 6.0 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4042) T2SSF PF00482.23 CDF39960.1 - 0.12 12.3 2.4 0.4 10.6 0.1 2.5 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F HEAT_PBS PF03130.16 CDF39960.1 - 0.16 12.7 2.8 40 5.3 0.1 4.9 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat ATP_bind_1 PF03029.17 CDF39962.1 - 2.4e-57 194.5 0.1 2.7e-57 194.3 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 CDF39962.1 - 0.22 11.0 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 CDF39963.1 - 1.1e-11 45.0 0.0 1.2e-11 44.9 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SRP54 PF00448.22 CDF39963.1 - 0.0029 17.2 0.0 0.0033 17.1 0.0 1.1 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 CDF39963.1 - 0.0085 15.8 0.0 0.0085 15.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF39963.1 - 0.013 16.1 0.0 0.013 16.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CDF39963.1 - 0.015 14.8 0.0 0.015 14.8 0.0 1.0 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ArsA_ATPase PF02374.15 CDF39963.1 - 0.022 14.0 0.0 0.024 13.8 0.0 1.0 1 0 0 1 1 1 0 Anion-transporting ATPase RNA_helicase PF00910.22 CDF39963.1 - 0.043 14.2 0.0 0.043 14.2 0.0 1.2 1 0 0 1 1 1 0 RNA helicase CbiA PF01656.23 CDF39963.1 - 0.07 13.2 0.0 0.076 13.1 0.0 1.0 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain CLP1_P PF16575.5 CDF39963.1 - 0.08 12.7 0.0 0.09 12.6 0.0 1.1 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_PrkA PF08298.11 CDF39963.1 - 0.089 11.7 0.0 0.092 11.6 0.0 1.0 1 0 0 1 1 1 0 PrkA AAA domain AAA_7 PF12775.7 CDF39963.1 - 0.092 12.3 0.0 0.098 12.2 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 CDF39963.1 - 0.13 12.6 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CDF39963.1 - 0.15 12.3 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CDF39963.1 - 0.16 10.9 0.0 0.18 10.7 0.0 1.0 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 CDF39963.1 - 0.16 11.1 0.0 0.18 11.0 0.0 1.0 1 0 0 1 1 1 0 KAP family P-loop domain Ribosomal_L10 PF00466.20 CDF39964.1 - 1.5e-20 73.2 0.8 3.1e-20 72.2 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 CDF39964.1 - 4.7e-20 71.4 0.2 1.2e-19 70.1 0.1 1.7 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 CDF39964.1 - 1.4e-13 51.3 13.2 1.8e-13 50.9 11.5 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein MutS_V PF00488.21 CDF39965.1 - 1.6e-63 214.2 0.8 2.9e-63 213.3 0.8 1.4 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 CDF39965.1 - 5.5e-32 110.4 0.0 1.5e-31 109.0 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 CDF39965.1 - 2.1e-28 99.8 0.1 7.4e-28 98.1 0.1 2.0 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CDF39965.1 - 6.8e-09 36.0 0.1 1.6e-08 34.8 0.1 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CDF39965.1 - 3.1e-05 24.3 0.1 0.00013 22.3 0.1 2.1 2 0 0 2 2 2 1 MutS domain II DUF4976 PF16347.5 CDF39965.1 - 0.026 14.8 0.1 0.069 13.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) DnaJ_CXXCXGXG PF00684.19 CDF39966.1 - 0.044 14.2 13.5 0.13 12.6 13.5 1.9 1 1 0 1 1 1 0 DnaJ central domain DUF1451 PF07295.11 CDF39966.1 - 1 9.4 5.0 2.1 8.4 5.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain Sel1 PF08238.12 CDF39968.1 - 1.5e-42 143.1 18.2 2.3e-05 24.9 0.1 9.1 9 0 0 9 9 9 8 Sel1 repeat TPR_6 PF13174.6 CDF39968.1 - 4.2e-16 58.4 13.5 0.0067 17.0 0.0 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDF39968.1 - 3.9e-10 39.4 7.7 2.8 8.5 0.0 9.0 9 2 0 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF39968.1 - 1.6e-07 31.8 29.1 0.24 12.1 1.5 8.2 6 3 3 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDF39968.1 - 0.00015 21.6 18.7 26 5.2 0.0 9.0 9 1 0 9 9 9 0 Tetratricopeptide repeat DUF2726 PF10881.8 CDF39968.1 - 0.00089 19.1 0.0 1.7 8.5 0.0 3.4 3 2 0 3 3 3 1 Protein of unknown function (DUF2726) TPR_14 PF13428.6 CDF39968.1 - 0.0023 18.6 26.5 23 6.1 0.4 8.4 5 3 4 9 9 9 0 Tetratricopeptide repeat Par3_HAL_N_term PF12053.8 CDF39968.1 - 0.016 15.4 0.2 0.94 9.7 0.0 3.4 4 0 0 4 4 4 0 N-terminal of Par3 and HAL proteins NSF PF02071.20 CDF39968.1 - 0.016 15.8 19.6 22 6.4 0.2 8.4 9 0 0 9 9 9 0 Aromatic-di-Alanine (AdAR) repeat Vps23_core PF09454.10 CDF39968.1 - 0.018 15.0 5.1 5.8 6.9 0.0 4.6 4 1 1 5 5 5 0 Vps23 core domain Lsm_C PF14894.6 CDF39968.1 - 0.057 13.2 1.4 93 2.9 0.0 4.2 4 0 0 4 4 4 0 Lsm C-terminal PPE PF00823.19 CDF39968.1 - 0.09 12.9 3.3 8.3 6.5 0.3 2.7 2 1 0 2 2 2 0 PPE family WzyE PF06899.11 CDF39968.1 - 0.19 10.6 0.0 0.4 9.5 0.0 1.4 2 0 0 2 2 2 0 WzyE protein, O-antigen assembly polymerase TPR_19 PF14559.6 CDF39968.1 - 1.4 9.5 29.0 31 5.2 0.4 8.3 4 1 5 9 9 9 0 Tetratricopeptide repeat ABC_membrane PF00664.23 CDF39970.1 - 6.9e-111 370.3 14.1 2.5e-56 191.3 5.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDF39970.1 - 9.2e-71 236.7 0.3 4.5e-35 121.1 0.0 2.8 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 CDF39970.1 - 7.5e-13 48.4 1.2 4.9e-05 22.9 0.1 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CDF39970.1 - 2.5e-08 33.5 0.0 0.0007 18.9 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_22 PF13401.6 CDF39970.1 - 6.6e-08 32.9 1.6 0.0077 16.5 0.1 3.7 2 2 0 2 2 2 2 AAA domain Rad17 PF03215.15 CDF39970.1 - 1.6e-05 24.9 0.0 0.088 12.7 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA PF00004.29 CDF39970.1 - 2.4e-05 24.8 0.2 1.1 9.7 0.0 4.3 3 1 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDF39970.1 - 3.2e-05 23.6 0.1 0.11 12.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDF39970.1 - 5e-05 23.3 0.0 0.13 12.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase ABC_ATPase PF09818.9 CDF39970.1 - 9.5e-05 21.4 1.1 0.11 11.3 0.1 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 CDF39970.1 - 0.0001 22.7 5.1 0.062 13.7 1.0 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 CDF39970.1 - 0.00014 21.9 0.5 5.1 7.1 0.0 4.5 5 0 0 5 5 5 1 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CDF39970.1 - 0.00017 20.9 0.0 0.18 10.9 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_28 PF13521.6 CDF39970.1 - 0.00068 19.9 0.5 0.97 9.7 0.1 3.2 2 1 0 3 3 3 1 AAA domain AAA_15 PF13175.6 CDF39970.1 - 0.0015 18.3 0.0 0.082 12.6 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDF39970.1 - 0.0023 17.7 8.0 0.91 9.2 0.3 4.0 2 2 0 2 2 2 2 AAA domain DUF815 PF05673.13 CDF39970.1 - 0.0028 16.9 0.0 1.6 7.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_21 PF13304.6 CDF39970.1 - 0.0054 16.6 0.1 4 7.1 0.0 3.5 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CDF39970.1 - 0.0056 16.8 0.0 5.9 6.9 0.0 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain APS_kinase PF01583.20 CDF39970.1 - 0.0072 16.2 0.0 3.3 7.6 0.0 2.7 2 0 0 2 2 2 1 Adenylylsulphate kinase SbcCD_C PF13558.6 CDF39970.1 - 0.008 16.4 3.6 0.78 10.0 0.5 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit PRK PF00485.18 CDF39970.1 - 0.0093 15.7 0.0 3 7.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 CDF39970.1 - 0.025 14.7 0.0 13 5.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDF39970.1 - 0.042 13.6 0.0 4.8 6.9 0.0 2.9 3 1 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 CDF39970.1 - 0.05 14.0 0.0 18 5.7 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 CDF39970.1 - 0.062 13.9 0.0 13 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain MoeA_C PF03454.15 CDF39970.1 - 0.064 13.4 0.7 12 6.1 0.0 3.0 3 0 0 3 3 2 0 MoeA C-terminal region (domain IV) SRP54 PF00448.22 CDF39970.1 - 0.065 12.8 0.1 4.6 6.8 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 CDF39970.1 - 0.079 12.5 0.0 5.7 6.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 CDF39970.1 - 0.084 12.4 3.6 4.3 6.9 0.0 3.0 4 0 0 4 4 3 0 AAA domain ERCC4 PF02732.15 CDF39973.1 - 2.7e-13 50.4 0.0 3.2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 ERCC4 domain Cyclin PF08613.11 CDF39974.1 - 8.4e-13 49.0 0.0 1.5e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CDF39974.1 - 4e-07 29.8 0.0 6.8e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PFK PF00365.20 CDF39975.1 - 3.2e-58 197.3 1.2 4.1e-58 197.0 1.2 1.1 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.21 CDF39975.1 - 0.015 14.5 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 ATP-NAD kinase DAGK_cat PF00781.24 CDF39975.1 - 0.021 14.4 0.0 0.076 12.6 0.0 1.9 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain MAF_flag10 PF01973.18 CDF39975.1 - 0.1 12.3 0.2 0.33 10.6 0.1 1.9 2 1 0 2 2 2 0 Protein of unknown function DUF115 Tyr_Deacylase PF02580.16 CDF39976.1 - 3.3e-40 137.9 0.0 3.7e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase WD40 PF00400.32 CDF39977.1 - 1.1e-38 130.5 20.3 1.3e-07 32.1 0.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Nucleoporin_N PF08801.11 CDF39977.1 - 0.00011 21.1 0.2 2.4 6.8 0.0 4.7 1 1 3 4 4 4 3 Nup133 N terminal like Nup160 PF11715.8 CDF39977.1 - 0.00039 19.2 7.0 1.2 7.6 0.1 4.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 CDF39977.1 - 0.069 12.5 0.0 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain Fcf1 PF04900.12 CDF39978.1 - 6.8e-34 116.2 1.4 7.7e-34 116.1 1.4 1.0 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 CDF39978.1 - 6.4e-08 32.9 0.1 7.5e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 PIN like domain DUF116 PF01976.17 CDF39978.1 - 0.0053 16.3 0.5 0.0076 15.8 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF116 GCV_T PF01571.21 CDF39978.1 - 0.082 12.3 0.0 0.12 11.7 0.0 1.2 1 1 0 1 1 1 0 Aminomethyltransferase folate-binding domain Pns11_12 PF17464.2 CDF39978.1 - 0.1 12.3 0.8 0.14 11.8 0.6 1.3 1 1 0 1 1 1 0 Non-structural protein 11 and 12 Sel1 PF08238.12 CDF39980.1 - 6.7e-70 229.9 44.1 1.6e-05 25.4 0.0 22.6 23 1 0 23 23 23 18 Sel1 repeat TPR_16 PF13432.6 CDF39980.1 - 0.0062 17.2 50.5 1.5 9.6 2.9 10.4 9 2 2 11 11 11 5 Tetratricopeptide repeat TPR_7 PF13176.6 CDF39980.1 - 0.24 11.5 23.2 42 4.5 0.3 10.6 13 0 0 13 13 13 0 Tetratricopeptide repeat TPR_5 PF12688.7 CDF39980.1 - 0.29 11.4 14.8 7.5 6.8 0.1 6.7 4 1 3 7 7 7 0 Tetratrico peptide repeat PPR_long PF17177.4 CDF39980.1 - 0.41 10.0 3.3 61 2.9 0.0 5.6 6 2 0 7 7 7 0 Pentacotripeptide-repeat region of PRORP DUF5610 PF18433.1 CDF39980.1 - 0.66 10.5 7.1 1.6 9.2 0.2 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF5610) Oxidored_FMN PF00724.20 CDF39981.1 - 6.8e-11 42.0 0.0 8e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CDF39981.1 - 0.00037 19.7 0.0 0.00048 19.3 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) PIF1 PF05970.14 CDF39982.1 - 1.1e-93 314.4 0.0 1.4e-93 313.9 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF39982.1 - 2.2e-17 63.9 1.0 1.7e-08 34.9 0.1 2.9 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF39982.1 - 7.3e-05 22.6 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF39982.1 - 0.13 10.2 0.0 0.2 9.5 0.0 1.2 1 0 0 1 1 1 0 Helicase NDUFA12 PF05071.16 CDF39984.1 - 1.2e-23 83.7 3.1 1.6e-23 83.4 3.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF3357 PF11837.8 CDF39985.1 - 0.0022 18.5 0.1 0.31 11.5 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3357) Herpes_gE PF02480.16 CDF39985.1 - 0.07 11.9 0.0 0.094 11.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Pkinase PF00069.25 CDF39989.1 - 3.1e-66 223.4 0.0 3.8e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF39989.1 - 2.3e-30 105.7 0.0 3.4e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF39989.1 - 0.00014 21.3 0.5 0.00045 19.6 0.5 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF39989.1 - 0.0015 17.4 0.0 0.002 17.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CDF39989.1 - 0.0017 17.4 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF39989.1 - 0.0023 17.9 0.1 0.0078 16.2 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF3870 PF12986.7 CDF39989.1 - 0.011 15.9 0.0 0.038 14.2 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) Kinase-like PF14531.6 CDF39989.1 - 0.077 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Mitofilin PF09731.9 CDF39991.1 - 1.1e-20 74.1 18.9 1.6e-20 73.5 18.9 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Retrotran_gag_2 PF14223.6 CDF39993.1 - 7.1e-24 84.0 1.2 1.4e-23 83.1 1.2 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF39993.1 - 6e-22 78.1 0.0 1.9e-21 76.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF39993.1 - 3.5e-07 30.0 0.0 1.1e-06 28.3 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF39993.1 - 0.00052 19.7 0.0 0.0016 18.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CDF39993.1 - 0.012 15.6 2.3 0.028 14.5 2.3 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF39993.1 - 0.03 14.0 1.0 0.11 12.3 1.0 2.0 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 CDF39993.1 - 0.46 10.4 1.5 0.93 9.4 1.5 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDF39993.1 - 0.85 9.5 5.0 2.6 8.0 5.0 1.8 1 0 0 1 1 1 0 Zinc knuckle AMPK1_CBM PF16561.5 CDF39997.1 - 1e-24 86.6 0.9 1.4e-24 86.1 0.9 1.2 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 CDF39997.1 - 4.9e-06 26.8 0.1 8e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Lumazine_bd_2 PF12893.7 CDF39997.1 - 0.032 14.9 0.2 0.055 14.2 0.2 1.5 1 1 0 1 1 1 0 Putative lumazine-binding Nipped-B_C PF12830.7 CDF39998.1 - 2e-14 54.0 0.0 6.6e-14 52.3 0.0 1.9 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Abhydrolase_1 PF00561.20 CDF39999.1 - 5.7e-23 81.9 0.2 1.1e-22 80.9 0.1 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF39999.1 - 1.6e-15 58.4 0.5 2.2e-15 57.9 0.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CDF39999.1 - 0.0019 18.3 0.0 0.004 17.3 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.8 CDF39999.1 - 0.0073 15.6 0.0 0.016 14.5 0.0 1.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ndr PF03096.14 CDF39999.1 - 0.022 13.5 0.0 0.048 12.4 0.0 1.5 2 0 0 2 2 2 0 Ndr family Chlorophyllase2 PF12740.7 CDF39999.1 - 0.05 12.5 0.0 0.11 11.4 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 CDF39999.1 - 0.085 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase CPBP PF02517.16 CDF40000.1 - 1.4e-14 54.2 0.0 1.6e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 CPBP intramembrane metalloprotease DUF2953 PF11167.8 CDF40000.1 - 0.15 12.1 0.1 0.33 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) DUF2781 PF10914.8 CDF40001.1 - 0.047 14.1 0.7 0.047 14.1 0.7 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) SLT PF01464.20 CDF40002.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain YjeF_N PF03853.15 CDF40003.1 - 1e-22 80.8 0.0 1.6e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus SLT PF01464.20 CDF40004.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain Myb_DNA-bind_2 PF08914.11 CDF40005.1 - 0.029 14.5 0.8 0.31 11.3 0.4 2.3 2 0 0 2 2 2 0 Rap1 Myb domain zf-C2H2_jaz PF12171.8 CDF40006.1 - 2.4e-08 34.1 7.8 8.7e-05 22.7 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CDF40006.1 - 1.2e-06 28.7 14.5 2.7e-05 24.4 3.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF40006.1 - 1.5e-05 25.4 12.7 0.018 15.8 3.9 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF40006.1 - 0.0017 18.7 0.4 0.0017 18.7 0.4 3.0 3 1 0 3 3 2 1 Zinc-finger double domain zf-C2H2_2 PF12756.7 CDF40006.1 - 0.012 15.9 9.5 0.022 15.1 0.7 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 CDF40006.1 - 0.023 15.1 3.1 0.023 15.1 3.1 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 CDF40006.1 - 0.094 13.4 10.6 0.93 10.2 1.7 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 CDF40006.1 - 0.23 11.9 9.1 2 8.9 1.9 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CDF40006.1 - 0.24 11.2 0.3 0.24 11.2 0.3 2.9 3 0 0 3 3 2 0 zinc-finger C2H2-type DUF629 PF04780.12 CDF40006.1 - 0.59 8.6 10.4 1.3 7.5 1.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Presenilin PF01080.17 CDF40006.1 - 0.68 8.6 1.5 0.71 8.6 1.5 1.1 1 0 0 1 1 1 0 Presenilin Apc15p PF05841.11 CDF40006.1 - 1.1 10.1 9.1 0.28 12.0 6.4 1.4 2 0 0 2 2 1 0 Apc15p protein TPT PF03151.16 CDF40007.1 - 1.6e-05 24.4 18.7 0.00051 19.5 18.7 2.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CDF40007.1 - 0.00019 20.8 18.6 0.0003 20.1 18.6 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDF40007.1 - 0.15 12.2 33.9 1.3 9.2 13.4 2.2 2 0 0 2 2 2 0 EamA-like transporter family ArAE_1 PF06081.11 CDF40007.1 - 0.66 10.1 9.7 0.038 14.1 3.4 2.1 2 1 0 2 2 2 0 Aromatic acid exporter family member 1 NB-ARC PF00931.22 CDF40008.1 - 1e-19 70.8 0.1 2.3e-19 69.6 0.1 1.5 1 0 0 1 1 1 1 NB-ARC domain TIR_2 PF13676.6 CDF40008.1 - 1.3e-16 61.2 0.0 4.7e-16 59.4 0.0 2.0 1 0 0 1 1 1 1 TIR domain ANAPC4_WD40 PF12894.7 CDF40008.1 - 1.1e-14 54.5 8.2 0.13 12.5 0.0 9.6 7 4 3 10 10 10 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40008.1 - 6.4e-10 39.5 22.3 0.14 13.1 0.2 9.0 10 0 0 10 10 10 4 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF40008.1 - 2.1e-08 34.0 19.4 8.2e-08 32.1 3.0 3.7 2 1 1 3 3 3 3 PQQ-like domain TIR PF01582.20 CDF40008.1 - 3e-07 30.4 0.0 9.5e-07 28.8 0.0 1.8 2 0 0 2 2 2 1 TIR domain eIF2A PF08662.11 CDF40008.1 - 0.008 16.1 2.6 0.31 10.9 0.0 3.9 3 2 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A APAF1_C PF17908.1 CDF40008.1 - 0.022 14.8 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain PQQ PF01011.21 CDF40008.1 - 0.53 10.3 13.8 0.66 10.0 0.2 5.4 6 0 0 6 6 6 0 PQQ enzyme repeat DUF1513 PF07433.11 CDF40008.1 - 0.61 9.1 3.3 13 4.8 0.0 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1513) Flavin_Reduct PF01613.18 CDF40010.1 - 1.5e-09 38.1 3.3 6.8e-09 36.0 1.4 2.6 2 1 0 2 2 2 1 Flavin reductase like domain Keratin_2_head PF16208.5 CDF40011.1 - 0.051 13.7 1.1 0.069 13.3 1.1 1.1 1 0 0 1 1 1 0 Keratin type II head GDP_Man_Dehyd PF16363.5 CDF40014.1 - 4.8e-66 223.4 0.0 5.5e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDF40014.1 - 4.1e-54 183.6 0.0 5.2e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDF40014.1 - 6.7e-20 71.2 0.0 9.6e-20 70.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDF40014.1 - 9.4e-18 64.3 0.1 4.3e-16 58.9 0.1 2.5 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 CDF40014.1 - 6.5e-17 61.6 0.0 1.8e-16 60.1 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDF40014.1 - 2.6e-16 59.6 0.0 3.5e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CDF40014.1 - 0.0015 18.4 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Methyltransf_31 PF13847.6 CDF40015.1 - 1.5e-17 63.8 0.0 2.3e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF40015.1 - 5e-13 49.6 0.0 8.7e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF40015.1 - 1.7e-10 41.5 0.0 2.8e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF40015.1 - 4e-10 39.8 0.0 7.9e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF40015.1 - 1.9e-07 31.6 0.0 3.5e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF40015.1 - 0.0001 21.7 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CDF40015.1 - 0.00023 20.7 0.0 0.00047 19.7 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 CDF40015.1 - 0.0013 18.3 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 CDF40015.1 - 0.0044 16.4 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.13 CDF40015.1 - 0.0087 15.5 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CDF40015.1 - 0.026 14.3 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 CDF40015.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Arginosuc_synth PF00764.19 CDF40016.1 - 7e-35 121.0 0.0 8.3e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Arginosuccinate synthase zf-RING_UBOX PF13445.6 CDF40017.1 - 6.5e-06 26.1 3.4 7.2e-06 25.9 3.4 1.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDF40017.1 - 0.00016 21.4 4.7 0.00019 21.2 4.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF40017.1 - 0.00028 21.2 6.8 0.00032 20.9 6.8 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 CDF40017.1 - 0.00059 19.9 5.9 0.0007 19.7 5.9 1.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CDF40017.1 - 0.0014 18.4 6.3 0.002 17.9 6.3 1.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF40017.1 - 0.0029 17.5 8.4 0.01 15.8 8.3 1.9 1 1 0 1 1 1 1 zinc-RING finger domain PIF1 PF05970.14 CDF40018.1 - 1.9e-99 333.3 0.0 2.9e-99 332.7 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF40018.1 - 6e-30 104.9 1.4 3.3e-16 60.1 0.1 2.3 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40018.1 - 3.8e-14 52.8 0.0 7.2e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF40018.1 - 0.0094 16.3 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 CDF40019.1 - 6.9e-20 71.3 0.0 1.3e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TIR_2 PF13676.6 CDF40019.1 - 1.6e-15 57.7 0.0 5.6e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 TIR domain ANAPC4_WD40 PF12894.7 CDF40019.1 - 4.3e-13 49.4 13.0 0.049 13.9 0.0 8.8 3 1 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40019.1 - 3.5e-09 37.1 16.2 0.1 13.5 0.2 7.9 7 1 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 CDF40019.1 - 1e-07 32.0 0.2 2.7e-06 27.4 0.0 3.0 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A TIR PF01582.20 CDF40019.1 - 6.4e-06 26.1 0.0 2e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 TIR domain PQQ_2 PF13360.6 CDF40019.1 - 0.00021 20.9 18.7 0.0019 17.8 12.2 3.9 3 1 0 3 3 3 1 PQQ-like domain PQQ PF01011.21 CDF40019.1 - 0.0073 16.2 10.8 0.37 10.8 0.1 5.5 6 0 0 6 6 6 1 PQQ enzyme repeat APAF1_C PF17908.1 CDF40019.1 - 0.015 15.3 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain TIR-like PF10137.9 CDF40019.1 - 0.092 12.7 0.0 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain PaO PF08417.12 CDF40020.1 - 8.1e-14 51.5 0.1 1.4e-12 47.5 0.0 2.6 2 0 0 2 2 2 1 Pheophorbide a oxygenase Rieske PF00355.26 CDF40020.1 - 1.3e-13 50.7 0.0 2.3e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PIF1 PF05970.14 CDF40022.1 - 2.2e-52 178.5 0.0 3.9e-52 177.6 0.0 1.4 1 1 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF40022.1 - 8.7e-29 101.1 1.9 4.1e-25 89.1 0.1 2.4 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40022.1 - 7e-08 32.4 0.0 1.3e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain UCR_Fe-S_N PF10399.9 CDF40022.1 - 0.099 12.0 1.7 0.25 10.7 1.7 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal HECT PF00632.25 CDF40023.1 - 4.6e-51 174.1 0.0 5.3e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) S-AdoMet_synt_C PF02773.16 CDF40024.1 - 1.1e-62 210.1 0.0 1.5e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDF40024.1 - 0.16 12.2 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, central domain CDH PF02611.15 CDF40025.1 - 0.0096 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase SDA1 PF05285.12 CDF40027.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 SDA1 tRNA_lig_CPD PF08302.11 CDF40027.1 - 0.2 11.1 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain MFS_1 PF07690.16 CDF40028.1 - 1.6e-35 122.7 35.4 1e-24 87.1 17.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDF40028.1 - 7.2e-34 117.4 20.8 2.5e-27 95.8 7.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter G0-G1_switch_2 PF15103.6 CDF40028.1 - 0.16 12.4 0.0 0.37 11.3 0.0 1.6 1 0 0 1 1 1 0 G0/G1 switch protein 2 Paramecium_SA PF01508.16 CDF40028.1 - 0.41 11.1 3.0 0.81 10.1 3.0 1.4 1 0 0 1 1 1 0 Paramecium surface antigen domain Lactamase_B PF00753.27 CDF40032.1 - 0.025 14.6 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Lactamase_B PF00753.27 CDF40033.1 - 2e-11 44.3 0.1 2.9e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDF40033.1 - 7.4e-07 28.9 0.1 1.2e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RVT_1 PF00078.27 CDF40036.1 - 4.6e-31 108.0 0.1 7e-31 107.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CDF40036.1 - 2.7e-18 65.8 0.0 6.5e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF40036.1 - 3e-09 37.1 0.0 6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Helicase_C PF00271.31 CDF40037.1 - 2.7e-15 56.7 0.0 7.4e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF40037.1 - 2.4e-10 40.4 0.0 8.4e-10 38.7 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF40037.1 - 0.0009 19.3 0.0 0.0041 17.1 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PAH PF02671.21 CDF40038.1 - 2e-13 50.3 0.4 6.8e-13 48.5 0.0 1.9 1 1 1 2 2 2 1 Paired amphipathic helix repeat APH PF01636.23 CDF40039.1 - 7.3e-09 35.9 0.3 1.4e-08 34.9 0.3 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF40039.1 - 0.15 11.3 0.0 0.6 9.4 0.0 1.8 1 1 0 1 1 1 0 Ecdysteroid kinase YojJ PF10372.9 CDF40039.1 - 0.27 11.4 1.2 1.1 9.4 0.0 2.4 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus ASC PF00858.24 CDF40042.1 - 0.0025 16.9 0.2 1.5 7.7 0.0 2.2 2 0 0 2 2 2 2 Amiloride-sensitive sodium channel TIMP PF00965.17 CDF40043.1 - 7e-12 45.5 0.0 1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Ald_Xan_dh_C2 PF02738.18 CDF40045.1 - 7.9e-63 212.8 0.0 9.9e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase zf-CHY PF05495.12 CDF40046.1 - 5.7e-11 42.8 19.1 5.7e-11 42.8 19.1 2.9 2 1 0 2 2 2 1 CHY zinc finger Fer4 PF00037.27 CDF40046.1 - 0.16 11.8 0.6 0.16 11.8 0.6 5.6 6 0 0 6 6 6 0 4Fe-4S binding domain RT_RNaseH_2 PF17919.1 CDF40047.1 - 2.4e-34 117.3 0.0 3.5e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF40047.1 - 9.4e-29 99.8 0.0 1.4e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF40047.1 - 7.2e-06 25.7 0.1 1e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 CDF40049.1 - 4.9e-54 179.1 23.7 7.1e-09 36.2 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40049.1 - 2.5e-16 59.7 7.7 0.02 15.2 0.0 7.2 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF40049.1 - 4.4e-06 25.6 8.2 5.5 5.5 0.0 6.7 4 3 1 7 7 7 2 Nucleoporin Nup120/160 PQQ PF01011.21 CDF40049.1 - 0.00097 19.0 0.0 1.8e+02 2.3 0.0 6.1 7 0 0 7 7 7 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 CDF40049.1 - 0.0027 16.7 0.5 3.1 6.7 0.0 4.6 1 1 5 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF40049.1 - 0.003 18.0 17.6 3.7 8.2 0.2 5.9 5 2 1 6 6 6 2 PQQ-like domain NB-ARC PF00931.22 CDF40049.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain PQQ_2 PF13360.6 CDF40049.1 - 0.016 14.8 26.8 0.088 12.4 8.0 2.6 1 1 1 2 2 2 0 PQQ-like domain HflK_N PF12221.8 CDF40049.1 - 0.056 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Bacterial membrane protein N terminal WD40_like PF17005.5 CDF40049.1 - 0.071 12.4 0.0 1.2e+02 1.8 0.0 4.7 5 1 1 6 6 6 0 WD40-like domain APAF1_C PF17908.1 CDF40049.1 - 0.14 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 APAF-1 helical domain Cytochrom_D1 PF02239.16 CDF40049.1 - 0.86 8.1 17.7 0.052 12.1 2.2 3.0 1 1 2 3 3 3 0 Cytochrome D1 heme domain CBM_20 PF00686.19 CDF40050.1 - 9e-09 35.1 0.0 1.6e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Starch binding domain PTPA PF03095.15 CDF40054.1 - 9e-37 127.1 0.0 1.3e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RT_RNaseH_2 PF17919.1 CDF40057.1 - 5.1e-35 119.5 0.0 1.6e-34 118.0 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF40057.1 - 4.5e-33 113.7 0.0 1.2e-32 112.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF40057.1 - 5e-19 68.6 0.0 8.7e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF40057.1 - 5.3e-13 48.9 0.0 1.3e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF40057.1 - 3.9e-07 29.8 0.0 6.9e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo PF00385.24 CDF40057.1 - 4.3e-06 26.5 0.0 8.1e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF40057.1 - 0.0029 17.3 0.1 0.014 15.2 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain AAA_13 PF13166.6 CDF40057.1 - 0.24 10.0 0.0 0.36 9.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain Ig_3 PF13927.6 CDF40063.1 - 0.034 14.7 0.2 0.2 12.3 0.1 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Sel1 PF08238.12 CDF40064.1 - 1.6e-74 244.6 19.6 7.8e-07 29.6 0.2 13.6 13 0 0 13 13 13 13 Sel1 repeat TPR_17 PF13431.6 CDF40064.1 - 7.3e-11 41.7 4.1 20 5.8 0.0 11.8 9 3 4 13 13 13 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40064.1 - 5.1e-07 30.2 17.2 11 6.8 0.1 10.3 7 3 4 12 12 12 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40064.1 - 1.2e-06 28.7 30.0 1.8 9.4 0.3 11.7 13 0 0 13 13 13 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40064.1 - 0.76 10.8 16.9 4.9 8.2 0.6 8.6 10 1 1 11 11 11 0 Tetratricopeptide repeat Cortexin PF11057.8 CDF40065.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.0 1 0 0 1 1 1 0 Cortexin of kidney Sel1 PF08238.12 CDF40066.1 - 4.8e-42 141.4 9.5 6.5e-06 26.6 0.0 8.2 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.6 CDF40066.1 - 1.1e-12 47.7 14.8 1.6 9.6 0.0 8.9 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40066.1 - 2.3e-09 37.8 23.3 0.076 13.7 0.6 5.7 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40066.1 - 2.5e-06 27.5 0.1 32 5.2 0.0 7.2 6 3 1 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40066.1 - 0.00012 22.5 26.1 3.5 8.7 0.9 7.5 6 2 2 8 8 8 2 Tetratricopeptide repeat NSF PF02071.20 CDF40066.1 - 0.0007 19.8 8.4 48 5.4 0.1 7.0 7 0 0 7 7 6 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.18 CDF40066.1 - 0.002 18.1 5.4 11 6.2 0.0 5.0 5 0 0 5 5 5 1 MIT (microtubule interacting and transport) domain ComR_TPR PF18710.1 CDF40066.1 - 0.0062 16.1 0.0 11 5.5 0.0 3.0 3 0 0 3 3 3 1 ComR tetratricopeptide TPR_7 PF13176.6 CDF40066.1 - 0.015 15.3 20.1 1.9 8.7 0.0 7.3 7 2 2 9 9 9 0 Tetratricopeptide repeat HEAT_2 PF13646.6 CDF40066.1 - 0.039 14.3 12.6 0.93 9.9 3.7 3.7 2 2 1 3 3 3 0 HEAT repeats Arg_decarb_HB PF17810.1 CDF40066.1 - 0.041 14.1 1.5 8.8 6.7 0.0 3.5 3 1 1 4 4 4 0 Arginine decarboxylase helical bundle domain HEPN_Apea PF18739.1 CDF40066.1 - 0.21 12.1 0.0 18 5.9 0.0 3.6 5 1 1 6 6 6 0 Apea-like HEPN TPR_1 PF00515.28 CDF40066.1 - 0.23 11.4 8.4 21 5.1 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat PIF1 PF05970.14 CDF40068.1 - 4.2e-101 338.7 0.0 9.4e-101 337.6 0.0 1.6 1 1 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF40068.1 - 2.8e-57 194.0 0.1 5.1e-57 193.2 0.1 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40068.1 - 1e-13 51.5 0.0 2e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF40068.1 - 0.016 15.5 0.0 0.043 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Herpes_Helicase PF02689.14 CDF40068.1 - 0.082 10.8 0.0 0.13 10.1 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF40068.1 - 0.12 12.0 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Glyco_hydro_45 PF02015.16 CDF40071.1 - 1.6e-06 28.2 12.1 5.4e-06 26.5 3.0 3.5 3 1 0 4 4 4 3 Glycosyl hydrolase family 45 DUF2157 PF09925.9 CDF40073.1 - 0.15 11.9 2.4 0.31 10.8 2.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Peptidase_M24 PF00557.24 CDF40077.1 - 1.1e-17 64.4 1.6 2.1e-17 63.5 1.6 1.6 1 1 0 1 1 1 1 Metallopeptidase family M24 Pkinase PF00069.25 CDF40078.1 - 1e-38 133.3 0.0 1.7e-38 132.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40078.1 - 7.6e-18 64.7 0.0 1.3e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ribonuc_2-5A PF06479.12 CDF40078.1 - 6.2e-16 58.7 0.7 8.1e-13 48.7 0.1 2.3 2 0 0 2 2 2 2 Ribonuclease 2-5A Pkinase_fungal PF17667.1 CDF40078.1 - 5.4e-05 22.1 0.0 0.0001 21.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDF40078.1 - 0.00062 19.8 0.9 0.072 13.0 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 CDF40078.1 - 0.018 14.7 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDF40078.1 - 0.07 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_A22B PF04258.13 CDF40082.1 - 3.6e-60 203.9 0.8 4.7e-60 203.5 0.8 1.1 1 0 0 1 1 1 1 Signal peptide peptidase GCP_C_terminal PF04130.13 CDF40083.1 - 2.3e-35 122.6 0.4 2.9e-35 122.2 0.4 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Pkinase PF00069.25 CDF40084.1 - 2.8e-64 217.0 0.0 5e-64 216.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40084.1 - 1.1e-36 126.5 0.0 1.9e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF40084.1 - 1.9e-07 30.7 0.0 3.1e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDF40084.1 - 0.0019 17.1 0.1 0.0054 15.5 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase PH PF00169.29 CDF40084.1 - 0.0038 17.7 0.3 0.018 15.5 0.3 2.2 1 1 0 1 1 1 1 PH domain APH PF01636.23 CDF40084.1 - 0.022 14.7 0.1 0.048 13.6 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CDF40084.1 - 0.029 13.7 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDF40084.1 - 0.059 13.0 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 CDF40084.1 - 0.15 11.5 1.0 0.45 10.0 0.0 2.3 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Aminotran_5 PF00266.19 CDF40085.1 - 3.6e-37 128.2 0.0 4e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V S1-like PF14444.6 CDF40085.1 - 0.018 15.0 0.0 0.054 13.4 0.0 1.7 2 0 0 2 2 2 0 S1-like Het-C PF07217.11 CDF40085.1 - 0.23 9.9 0.1 0.3 9.6 0.1 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C NAD_Gly3P_dh_C PF07479.14 CDF40086.1 - 2.2e-42 144.7 0.2 3.7e-42 144.0 0.2 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 CDF40086.1 - 1e-40 139.3 0.0 1.5e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 CDF40086.1 - 3e-05 23.7 0.0 5.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 CDF40086.1 - 0.001 19.0 0.0 0.0043 16.9 0.0 1.9 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDF40086.1 - 0.0055 16.0 0.0 0.029 13.6 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 CDF40086.1 - 0.012 16.2 0.0 0.055 14.0 0.0 2.1 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 CDF40086.1 - 0.012 16.1 0.0 0.095 13.3 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CDF40086.1 - 0.033 14.5 0.0 0.32 11.3 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_3 PF01494.19 CDF40086.1 - 0.072 12.3 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain PPR_2 PF13041.6 CDF40088.1 - 2.8e-32 110.7 5.1 1.2e-07 31.8 0.0 10.1 9 1 3 12 12 12 7 PPR repeat family PPR PF01535.20 CDF40088.1 - 1.3e-25 87.8 14.9 0.0013 18.9 0.0 13.1 14 0 0 14 14 14 4 PPR repeat PPR_3 PF13812.6 CDF40088.1 - 1.1e-22 79.8 0.0 8.9e-05 22.5 0.0 7.5 7 1 1 8 8 8 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 CDF40088.1 - 5.7e-18 64.3 11.4 0.00038 20.1 0.0 10.4 10 0 0 10 10 10 5 PPR repeat PPR_long PF17177.4 CDF40088.1 - 1.9e-10 40.5 1.4 0.003 16.9 0.0 6.2 4 1 2 6 6 6 3 Pentacotripeptide-repeat region of PRORP Cellulase PF00150.18 CDF40089.1 - 1.5e-17 64.0 0.5 1.9e-17 63.6 0.5 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PQ-loop PF04193.14 CDF40090.1 - 2.1e-30 104.3 6.4 2.4e-14 52.9 4.1 2.5 2 0 0 2 2 2 2 PQ loop repeat CreD PF06123.12 CDF40091.1 - 0.023 13.5 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 Inner membrane protein CreD TIR_2 PF13676.6 CDF40092.1 - 3.6e-15 56.6 0.0 1.2e-14 54.9 0.0 2.0 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF40092.1 - 2e-09 37.5 0.0 4.7e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 TIR domain Roc PF08477.13 CDF40092.1 - 3.1e-09 37.1 0.0 1.4e-05 25.3 0.0 2.9 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 CDF40092.1 - 0.00011 22.0 0.1 0.0024 17.7 0.0 2.6 3 0 0 3 3 3 1 C-terminal of Roc, COR, domain Ras PF00071.22 CDF40092.1 - 0.00056 19.5 0.0 0.27 10.8 0.0 2.4 2 0 0 2 2 2 2 Ras family Arf PF00025.21 CDF40092.1 - 0.038 13.4 0.0 3.4 7.1 0.0 2.7 2 0 0 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.20 CDF40092.1 - 0.039 13.1 0.0 0.099 11.8 0.0 1.7 1 1 0 1 1 1 0 G-protein alpha subunit AAA_16 PF13191.6 CDF40092.1 - 0.091 13.1 0.1 0.61 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain TIR_2 PF13676.6 CDF40096.1 - 9e-13 48.9 0.0 5.4e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 TIR domain Roc PF08477.13 CDF40096.1 - 2.8e-09 37.2 0.1 1.2e-05 25.5 0.0 3.1 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase TIR PF01582.20 CDF40096.1 - 8.2e-07 29.0 0.0 2.5e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 TIR domain COR PF16095.5 CDF40096.1 - 1.2e-06 28.5 0.0 3.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Ras PF00071.22 CDF40096.1 - 0.0012 18.5 0.0 0.37 10.4 0.0 2.5 2 0 0 2 2 2 2 Ras family TPR_14 PF13428.6 CDF40096.1 - 0.0047 17.6 0.2 3.1 8.8 0.1 4.4 2 1 1 3 3 3 1 Tetratricopeptide repeat Pyr_redox_2 PF07992.14 CDF40097.1 - 1.1e-42 146.3 0.1 1.4e-42 145.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 CDF40097.1 - 2.3e-18 66.8 2.3 6.9e-13 49.1 0.0 2.9 2 1 1 3 3 3 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 CDF40097.1 - 2.1e-11 44.2 1.7 3e-11 43.7 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDF40097.1 - 0.00027 19.8 0.5 0.17 10.5 0.0 3.1 2 1 1 3 3 3 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDF40097.1 - 0.00089 18.6 0.0 0.002 17.5 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDF40097.1 - 0.0011 19.0 0.8 7.5 6.5 0.0 4.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CDF40097.1 - 0.0028 16.8 0.0 0.02 14.1 0.0 2.1 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 CDF40097.1 - 0.022 15.2 0.4 5.8 7.4 0.2 3.4 3 0 0 3 3 3 0 Putative NAD(P)-binding DAO PF01266.24 CDF40097.1 - 0.033 13.8 5.5 0.56 9.7 0.0 3.1 4 0 0 4 4 4 0 FAD dependent oxidoreductase GIDA PF01134.22 CDF40097.1 - 0.14 11.3 0.4 0.31 10.1 0.4 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A DAHP_synth_2 PF01474.16 CDF40098.1 - 7.2e-124 413.6 0.0 8.2e-124 413.4 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family ABC_tran PF00005.27 CDF40100.1 - 4.7e-11 43.3 0.0 5e-11 43.3 0.0 1.0 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF40100.1 - 0.0003 20.7 0.0 0.0003 20.7 0.0 1.0 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDF40100.1 - 0.00045 20.6 0.0 0.00046 20.6 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CDF40100.1 - 0.0014 18.8 0.0 0.0014 18.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDF40100.1 - 0.0014 18.7 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF40100.1 - 0.0031 17.4 0.2 0.0038 17.2 0.2 1.3 1 1 0 1 1 1 1 RsgA GTPase Zeta_toxin PF06414.12 CDF40100.1 - 0.0036 16.6 0.0 0.0039 16.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 CDF40100.1 - 0.0047 16.6 0.2 0.011 15.5 0.1 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 CDF40100.1 - 0.0082 16.4 0.0 0.0084 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF40100.1 - 0.019 15.5 0.0 0.019 15.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDF40100.1 - 0.021 15.1 0.0 0.026 14.8 0.0 1.2 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDF40100.1 - 0.024 14.3 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 CDF40100.1 - 0.027 15.0 0.0 0.027 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CDF40100.1 - 0.045 13.6 0.0 0.045 13.6 0.0 1.1 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_24 PF13479.6 CDF40100.1 - 0.058 13.1 0.0 0.058 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 CDF40100.1 - 0.11 9.9 0.0 0.12 9.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_30 PF13604.6 CDF40100.1 - 0.14 11.9 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 CDF40100.1 - 0.14 11.9 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 CDF40100.1 - 0.23 11.5 0.2 0.31 11.1 0.2 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain Kri1_C PF12936.7 CDF40101.1 - 2.5e-23 82.1 1.7 2.5e-23 82.1 1.7 3.8 5 0 0 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 CDF40101.1 - 8.7e-17 61.6 8.3 8.7e-17 61.6 8.3 4.7 4 2 1 5 5 5 1 KRI1-like family Tli4_C PF18426.1 CDF40101.1 - 2.4 8.4 8.4 0.59 10.4 0.1 3.4 3 1 1 4 4 4 0 Tle cognate immunity protein 4 C-terminal domain Hint_2 PF13403.6 CDF40104.1 - 0.048 14.0 0.8 0.062 13.6 0.8 1.2 1 0 0 1 1 1 0 Hint domain AIRS_C PF02769.22 CDF40105.1 - 1.5e-23 83.7 0.0 9.5e-23 81.1 0.0 2.3 2 1 0 2 2 2 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDF40105.1 - 9.1e-14 51.9 0.4 1.9e-13 50.9 0.4 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain UQ_con PF00179.26 CDF40106.1 - 1.4e-38 131.7 0.0 1.6e-27 95.9 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDF40106.1 - 0.008 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDF40106.1 - 0.0094 16.2 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 RWD domain ORC5_C PF14630.6 CDF40107.1 - 1.3e-41 143.0 0.0 2.1e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus LSM PF01423.22 CDF40108.1 - 2.2e-16 59.3 0.2 2.6e-16 59.1 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDF40108.1 - 0.01 15.9 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain zf-C2H2 PF00096.26 CDF40112.1 - 4.7e-27 92.9 33.6 6.6e-07 29.5 0.2 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDF40112.1 - 2.6e-22 78.2 36.5 1.3e-06 28.6 0.2 7.3 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDF40112.1 - 5.1e-16 58.0 34.1 0.0018 18.9 0.3 6.3 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 CDF40112.1 - 5.7e-05 23.8 13.3 1.8 9.3 0.1 4.7 1 1 3 4 4 4 3 Zinc finger C2H2-type, 3 repeats TRAF6_Z2 PF18048.1 CDF40112.1 - 0.00016 21.6 9.2 0.86 9.7 0.2 5.0 4 0 0 4 4 4 2 TNF receptor-associated factor 6 zinc finger 2 zf_C2H2_ZHX PF18387.1 CDF40112.1 - 0.0077 15.8 0.9 0.0077 15.8 0.9 3.9 3 1 2 5 5 5 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_8 PF15909.5 CDF40112.1 - 0.0091 16.3 15.6 0.025 14.9 4.5 3.2 1 1 3 4 4 4 3 C2H2-type zinc ribbon FOXP-CC PF16159.5 CDF40112.1 - 0.013 16.1 14.0 1.3 9.7 0.1 4.1 2 1 3 5 5 5 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 CDF40112.1 - 0.04 13.7 23.6 0.55 10.0 2.3 5.8 6 0 0 6 6 6 0 zinc-finger C2H2-type zf_Hakai PF18408.1 CDF40112.1 - 0.054 13.2 0.5 0.054 13.2 0.5 3.8 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain zf-C2H2_9 PF16293.5 CDF40112.1 - 0.24 11.3 5.8 0.49 10.3 0.1 3.8 3 2 2 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-H2C2_5 PF13909.6 CDF40112.1 - 0.35 10.7 0.1 0.35 10.7 0.1 7.6 8 2 0 8 8 8 0 C2H2-type zinc-finger domain CpXC PF14353.6 CDF40112.1 - 1.3 9.1 5.7 1.9 8.6 0.6 2.8 2 1 1 3 3 3 0 CpXC protein zf-C2H2_jaz PF12171.8 CDF40112.1 - 1.5 9.2 0.0 1.5 9.2 0.0 5.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 CDF40112.1 - 2.5 7.8 5.6 42 3.8 1.2 3.5 4 0 0 4 4 4 0 MYST family zinc finger domain GAGA PF09237.11 CDF40112.1 - 2.7 7.9 9.6 1.4 8.8 0.2 3.6 2 2 2 4 4 4 0 GAGA factor FYDLN_acid PF09538.10 CDF40112.1 - 5 7.9 6.4 5.4 7.7 0.3 3.0 3 1 0 4 4 3 0 Protein of unknown function (FYDLN_acid) Not3 PF04065.15 CDF40113.1 - 1.1e-87 293.3 18.8 1.5e-87 292.9 18.8 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 CDF40113.1 - 1.5e-38 131.8 0.7 3.2e-38 130.8 0.7 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Spc7 PF08317.11 CDF40113.1 - 0.53 9.1 16.3 0.91 8.3 1.3 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein DivIC PF04977.15 CDF40113.1 - 8.3 6.3 8.4 11 5.9 0.4 3.3 2 1 1 3 3 3 0 Septum formation initiator RIC1 PF07064.13 CDF40114.1 - 6.1e-46 156.9 0.0 1e-45 156.1 0.0 1.3 1 0 0 1 1 1 1 RIC1 Peptidase_M18 PF02127.15 CDF40115.1 - 6.1e-147 489.9 0.0 7.2e-147 489.7 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CDF40115.1 - 0.00012 21.2 0.0 0.0046 16.0 0.0 2.2 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase TPR_1 PF00515.28 CDF40116.1 - 3.3e-39 131.1 11.0 1.3e-06 28.0 0.0 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 CDF40116.1 - 9.7e-37 122.1 9.2 7.5e-05 22.6 0.0 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40116.1 - 2.6e-29 98.9 4.7 0.0094 16.1 0.1 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40116.1 - 1.3e-20 73.8 5.5 6.1e-10 39.6 0.4 6.8 4 1 3 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40116.1 - 2.5e-19 68.2 14.0 0.00062 20.0 0.0 8.8 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40116.1 - 4.2e-19 67.6 6.3 0.00024 21.7 0.1 8.4 3 2 5 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.6 CDF40116.1 - 2.1e-18 66.2 4.4 2e-06 27.9 0.6 5.1 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDF40116.1 - 4.2e-18 64.8 10.5 1.9e-06 27.4 0.4 7.4 6 1 2 8 8 7 3 TPR repeat TPR_19 PF14559.6 CDF40116.1 - 4.5e-17 62.3 0.9 6.6e-05 23.3 0.2 5.4 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDF40116.1 - 3.6e-13 49.6 12.7 0.00028 21.1 1.3 6.5 4 1 3 7 7 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40116.1 - 1.7e-12 47.1 6.2 1.4 9.7 0.3 9.3 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF40116.1 - 4.9e-10 38.7 5.8 0.34 11.0 0.2 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDF40116.1 - 1.2e-09 37.8 3.0 0.11 11.7 0.0 4.8 1 1 2 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF40116.1 - 0.00015 22.0 8.3 0.039 14.2 0.5 4.5 2 2 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 CDF40116.1 - 0.00016 20.8 0.0 0.37 9.7 0.0 2.7 2 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 CDF40116.1 - 0.00033 20.9 1.1 1.7 9.1 0.2 4.1 3 2 1 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 CDF40116.1 - 0.00041 19.4 0.2 5.1 5.9 0.0 3.2 2 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 CDF40116.1 - 0.0044 16.8 0.3 0.72 9.5 0.0 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 CDF40116.1 - 0.012 15.5 0.9 5 7.1 0.5 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CDF40116.1 - 0.014 14.8 0.1 2.1 7.6 0.0 3.1 1 1 1 3 3 3 0 MalT-like TPR region SNAP PF14938.6 CDF40116.1 - 0.26 10.7 6.2 6.5 6.1 0.9 3.6 1 1 2 4 4 4 0 Soluble NSF attachment protein, SNAP BTAD PF03704.17 CDF40116.1 - 0.38 11.2 3.4 9.9 6.6 0.0 2.8 3 0 0 3 3 2 0 Bacterial transcriptional activator domain TOM20_plant PF06552.12 CDF40116.1 - 0.39 10.5 1.0 32 4.2 0.0 2.7 3 0 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_3 PF07720.12 CDF40116.1 - 2.3 8.3 6.4 38 4.4 0.5 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat DDE_3 PF13358.6 CDF40119.1 - 4.6e-08 32.9 0.0 6.9e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease RRM_1 PF00076.22 CDF40120.1 - 2.1e-19 69.1 0.0 2.6e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOT2_3_5 PF04153.18 CDF40121.1 - 2.9e-23 82.4 1.4 4.8e-23 81.7 1.4 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Ribosomal_L22e PF01776.17 CDF40122.1 - 2.1e-48 163.2 2.0 2.6e-48 162.9 2.0 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Pkinase_Tyr PF07714.17 CDF40123.1 - 1.1e-18 67.5 0.0 6.6e-11 42.0 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDF40123.1 - 5.2e-17 62.1 0.0 1.8e-10 40.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pro_isomerase PF00160.21 CDF40125.1 - 2.9e-47 160.8 0.2 3.3e-47 160.7 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD VPS13_C PF16909.5 CDF40126.1 - 3.1e-27 95.5 0.7 5e-23 81.8 0.0 2.5 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 CDF40126.1 - 4.1e-27 95.5 0.0 5.2e-26 91.9 0.0 2.6 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 CDF40126.1 - 4.2e-26 91.3 0.0 1e-25 90.1 0.0 1.7 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 CDF40126.1 - 1.7e-09 37.5 0.0 6.2e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 CDF40126.1 - 5.1e-05 23.5 0.1 0.00016 21.9 0.1 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain UBA PF00627.31 CDF40126.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain DDE_3 PF13358.6 CDF40127.1 - 6.2e-05 22.8 0.0 9.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF40128.1 - 2.3e-06 27.3 0.0 3.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF40128.1 - 0.00034 20.3 0.1 0.0005 19.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF40128.1 - 0.059 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Pentapeptide PF00805.22 CDF40129.1 - 0.0054 16.4 0.3 0.0086 15.7 0.3 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Hint PF01079.20 CDF40130.1 - 8.7e-27 94.0 0.0 1.8e-26 93.0 0.0 1.4 1 1 0 1 1 1 1 Hint module WD40 PF00400.32 CDF40131.1 - 1.7e-46 155.2 18.8 1.5e-09 38.3 0.0 8.7 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40131.1 - 6.1e-25 87.3 0.6 2.9e-05 24.3 0.0 6.8 2 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF40131.1 - 1.7e-11 44.4 0.4 0.00034 20.6 0.1 3.2 2 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 CDF40131.1 - 8.7e-10 38.2 0.3 1.6e-09 37.4 0.3 1.5 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 CDF40131.1 - 0.00016 21.1 0.0 0.046 13.0 0.0 2.8 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 CDF40131.1 - 0.00048 18.9 5.7 0.21 10.2 0.2 3.6 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDF40131.1 - 0.0039 16.2 0.3 8.4 5.2 0.0 4.0 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cu_amine_oxidN1 PF07833.11 CDF40131.1 - 0.09 13.3 0.0 2.6 8.6 0.0 2.9 3 0 0 3 3 3 0 Copper amine oxidase N-terminal domain Utp12 PF04003.12 CDF40132.1 - 0.026 14.8 0.1 0.078 13.3 0.1 2.0 1 1 0 1 1 1 0 Dip2/Utp12 Family HZS_alpha PF18582.1 CDF40132.1 - 0.1 13.1 0.0 0.9 10.1 0.0 2.5 2 0 0 2 2 2 0 Hydrazine synthase alpha subunit middle domain MOZ_SAS PF01853.18 CDF40135.1 - 2.4e-83 278.2 0.5 3.4e-83 277.7 0.5 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CDF40135.1 - 5.3e-21 74.0 1.3 5.3e-21 74.0 1.3 1.9 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDF40135.1 - 1.8e-18 66.2 0.5 3.9e-18 65.1 0.5 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CDF40135.1 - 0.0011 19.4 0.0 0.0023 18.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDF40135.1 - 0.013 15.7 0.0 0.039 14.2 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family PocR PF10114.9 CDF40135.1 - 0.025 14.4 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Sensory domain found in PocR FemAB PF02388.16 CDF40135.1 - 0.029 13.3 0.1 0.055 12.3 0.1 1.4 1 0 0 1 1 1 0 FemAB family RNA_pol_Rpc4 PF05132.14 CDF40135.1 - 3.8 7.9 11.3 0.12 12.8 1.9 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 DCP2 PF05026.13 CDF40137.1 - 4.6e-28 97.4 3.3 8.5e-28 96.5 3.3 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 CDF40137.1 - 1.2e-13 51.2 0.0 2.5e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain GST_N_3 PF13417.6 CDF40140.1 - 7.8e-14 51.9 0.0 1.9e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF40140.1 - 1.1e-09 38.4 0.1 8.1e-09 35.7 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDF40140.1 - 4.2e-07 30.2 0.0 8.8e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CDF40140.1 - 0.0055 16.9 0.0 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin Trimer_CC PF08954.11 CDF40140.1 - 0.088 12.4 0.1 0.29 10.7 0.1 1.9 1 0 0 1 1 1 0 Trimerisation motif Pheromone PF08015.11 CDF40140.1 - 1.2 10.3 4.2 26 5.9 4.8 2.4 2 0 0 2 2 2 0 Fungal mating-type pheromone TPR_2 PF07719.17 CDF40144.1 - 1e-11 44.0 0.1 0.0044 17.0 0.2 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40144.1 - 1.3e-09 38.4 0.0 2.6e-05 24.7 0.0 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40144.1 - 5.6e-09 36.5 1.2 1.5e-06 28.8 0.1 3.4 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40144.1 - 4.2e-08 33.0 0.0 0.00025 21.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF40144.1 - 3.1e-07 30.6 1.2 0.021 15.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40144.1 - 3.3e-06 26.9 0.0 0.015 15.4 0.1 4.2 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40144.1 - 3.9e-06 26.4 0.2 0.0047 16.7 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDF40144.1 - 4e-05 23.3 0.4 1.2 9.3 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40144.1 - 5.7e-05 23.6 9.2 0.81 10.7 0.0 6.0 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDF40144.1 - 0.0007 19.2 0.0 0.12 12.1 0.0 3.1 1 1 1 3 3 3 1 TPR repeat TPR_15 PF13429.6 CDF40144.1 - 0.0028 16.9 0.4 0.014 14.6 0.3 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDF40144.1 - 0.003 17.4 1.6 0.16 11.9 0.2 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF40144.1 - 0.0064 16.6 0.2 0.32 11.2 0.0 3.1 1 1 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 CDF40144.1 - 0.0076 16.7 0.8 0.21 12.0 0.1 2.9 2 0 0 2 2 2 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 CDF40144.1 - 0.015 15.5 0.1 0.16 12.2 0.0 2.5 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CDF40144.1 - 0.1 12.9 0.1 0.1 12.9 0.1 2.9 4 0 0 4 4 2 0 Tetratricopeptide repeat Vpu PF00558.19 CDF40144.1 - 0.13 12.0 0.3 0.37 10.6 0.3 1.7 1 0 0 1 1 1 0 Vpu protein RRM_1 PF00076.22 CDF40145.1 - 2e-19 69.1 0.0 5.8e-19 67.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF40145.1 - 0.0013 18.8 0.0 0.0032 17.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif Asn_synthase PF00733.21 CDF40146.1 - 4.3e-21 76.0 0.8 3.4e-10 40.1 0.1 3.0 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CDF40146.1 - 3.7e-06 26.9 0.0 2.7e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase domain DEAD PF00270.29 CDF40147.1 - 1e-39 136.1 0.1 1.6e-39 135.5 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF40147.1 - 2.2e-26 92.4 0.4 5.7e-25 87.8 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CMS1 PF14617.6 CDF40147.1 - 0.0018 17.6 0.1 0.0032 16.8 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Phage-A118_gp45 PF10653.9 CDF40147.1 - 0.055 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Protein gp45 of Bacteriophage A118 Chloroa_b-bind PF00504.21 CDF40148.1 - 1.5e-35 123.1 0.0 8.5e-35 120.7 0.0 1.8 2 0 0 2 2 2 1 Chlorophyll A-B binding protein Sugarporin_N PF11471.8 CDF40150.1 - 0.15 12.0 0.1 0.3 11.1 0.1 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension PHO4 PF01384.20 CDF40152.1 - 2.7e-90 302.8 31.9 3.1e-90 302.6 31.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 CDF40152.1 - 0.0012 18.6 0.3 1.5 8.7 0.0 2.8 3 0 0 3 3 3 2 IclR helix-turn-helix domain DUF5357 PF17310.2 CDF40152.1 - 0.081 11.5 4.1 0.13 10.8 4.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5357) Prefoldin_2 PF01920.20 CDF40154.1 - 2.5e-16 59.6 0.3 3.1e-16 59.2 0.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit CASP_C PF08172.12 CDF40154.1 - 0.0006 19.2 0.2 0.0006 19.2 0.2 1.2 1 0 0 1 1 1 1 CASP C terminal ArsR PF09824.9 CDF40154.1 - 0.0038 16.8 0.1 0.0053 16.4 0.1 1.2 1 0 0 1 1 1 1 ArsR transcriptional regulator tRNA-synt_1g PF09334.11 CDF40157.1 - 2.7e-64 217.3 0.0 3.7e-63 213.6 0.0 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CDF40157.1 - 3.1e-15 55.5 0.0 4.2e-14 51.7 0.0 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CDF40157.1 - 5.2e-05 22.7 0.0 9.3e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain NIF PF03031.18 CDF40158.1 - 5.5e-14 52.2 0.0 1.2e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase APO_RNA-bind PF05634.11 CDF40159.1 - 0.15 11.4 1.3 0.26 10.6 1.3 1.3 1 0 0 1 1 1 0 APO RNA-binding PH PF00169.29 CDF40160.1 - 0.0022 18.5 0.1 0.0058 17.1 0.1 1.7 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 CDF40160.1 - 0.0063 16.8 0.1 0.0095 16.2 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain GATA PF00320.27 CDF40161.1 - 2.5e-11 43.0 6.7 2.5e-11 43.0 6.7 2.1 2 0 0 2 2 2 1 GATA zinc finger DUF2318 PF10080.9 CDF40161.1 - 0.011 15.9 0.1 0.021 15.0 0.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Paired_CXXCH_1 PF09699.10 CDF40161.1 - 0.055 13.2 2.0 0.069 12.9 0.6 2.0 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) DZR PF12773.7 CDF40161.1 - 0.16 12.0 3.5 0.16 12.0 0.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon WD40 PF00400.32 CDF40162.1 - 3.4e-16 59.3 12.4 0.0015 19.3 0.0 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF40162.1 - 3.5e-05 23.5 0.1 0.00045 19.9 0.0 2.2 1 1 0 1 1 1 1 PQQ-like domain ANAPC4_WD40 PF12894.7 CDF40162.1 - 3.7e-05 23.9 0.0 1.9 8.8 0.0 4.6 1 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CDF40162.1 - 0.0056 17.1 5.0 22 5.7 0.1 5.5 5 1 1 6 6 6 1 PQQ-like domain Me-amine-dh_H PF06433.11 CDF40162.1 - 0.057 12.3 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Ge1_WD40 PF16529.5 CDF40162.1 - 0.1 11.5 0.0 0.72 8.7 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Aminotran_1_2 PF00155.21 CDF40163.1 - 7.8e-52 176.6 0.0 8.9e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDF40163.1 - 3.4e-06 26.6 0.0 8.5e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CDF40163.1 - 0.0073 14.9 0.0 0.011 14.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDF40163.1 - 0.092 11.7 0.0 0.18 10.7 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V 2-Hacid_dh_C PF02826.19 CDF40164.1 - 2.4e-61 206.2 0.0 1.1e-60 204.0 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDF40164.1 - 4.7e-29 100.7 0.0 5.5e-29 100.5 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDF40164.1 - 0.00019 21.6 0.0 0.00043 20.5 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CDF40164.1 - 0.00067 19.3 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 CDF40164.1 - 0.0043 17.1 0.0 0.0086 16.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain F420_oxidored PF03807.17 CDF40164.1 - 0.0069 17.0 0.0 0.015 15.8 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CDF40164.1 - 0.011 15.8 0.0 0.035 14.2 0.0 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CDF40164.1 - 0.031 14.7 0.0 0.071 13.6 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding FH2 PF02181.23 CDF40165.1 - 7.6e-67 226.0 14.3 2.1e-62 211.4 1.0 3.0 3 0 0 3 3 3 2 Formin Homology 2 Domain Ras PF00071.22 CDF40166.1 - 1.7e-35 122.0 0.1 2e-35 121.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF40166.1 - 1.7e-10 41.2 0.0 2.7e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF40166.1 - 0.0052 16.3 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDF40166.1 - 0.017 15.2 0.1 0.049 13.7 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF40166.1 - 0.039 13.9 0.6 4.3 7.2 0.1 2.2 1 1 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 CDF40166.1 - 0.086 12.4 0.1 0.27 10.8 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.6 CDF40166.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DEC-1_N PF04625.13 CDF40166.1 - 0.19 10.7 2.5 0.3 10.1 2.5 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region NARP1 PF12569.8 CDF40167.1 - 6.6e-156 520.2 2.9 1.6e-154 515.7 0.1 2.3 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 CDF40167.1 - 2.4e-18 64.7 22.0 0.0028 17.6 0.8 9.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40167.1 - 1.8e-16 59.4 18.0 0.14 13.0 0.0 9.0 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40167.1 - 1e-14 54.9 21.8 0.023 15.3 0.0 7.9 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40167.1 - 2.5e-12 45.9 6.0 0.05 13.8 0.3 6.5 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40167.1 - 1.1e-11 44.0 14.5 0.048 13.5 0.0 8.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40167.1 - 1.5e-10 41.4 24.2 0.0061 17.1 0.1 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF40167.1 - 1.4e-08 34.3 6.8 0.0056 16.3 1.0 4.8 4 0 0 4 4 4 2 TPR repeat TPR_7 PF13176.6 CDF40167.1 - 1.6e-07 30.8 14.5 0.14 12.3 0.1 7.6 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDF40167.1 - 9.8e-07 28.8 13.5 1.9 8.7 0.6 7.1 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40167.1 - 3.4e-06 27.0 6.0 0.54 10.8 0.0 6.7 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 CDF40167.1 - 5.8e-05 23.3 6.4 3 8.7 1.1 6.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40167.1 - 7.1e-05 23.2 6.2 16 6.4 0.1 7.0 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF40167.1 - 8.1e-05 22.8 19.8 0.0074 16.5 0.3 6.2 5 2 1 7 7 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDF40167.1 - 0.00015 22.0 22.3 0.26 11.6 0.1 8.3 7 2 1 9 9 9 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDF40167.1 - 1.6 8.7 7.2 63 3.6 0.1 5.4 7 0 0 7 7 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF40167.1 - 3 8.0 10.5 9.2 6.4 0.0 4.9 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Hydrolase_4 PF12146.8 CDF40168.1 - 4.7e-09 35.9 0.2 0.0011 18.2 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CDF40168.1 - 1.9e-08 34.0 0.0 5.3e-07 29.3 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDF40168.1 - 1.7e-07 31.1 0.0 0.0042 16.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 CDF40168.1 - 3.3e-06 26.8 0.0 6.4e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CDF40168.1 - 0.0016 18.3 0.0 0.0044 16.9 0.0 1.6 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 CDF40168.1 - 0.002 18.1 0.5 2 8.3 0.2 2.2 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Asp2 PF16929.5 CDF40168.1 - 0.0038 16.3 0.0 0.0059 15.6 0.0 1.2 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter FSH1 PF03959.13 CDF40168.1 - 0.024 14.3 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 CDF40168.1 - 0.079 12.8 1.0 0.24 11.2 0.5 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold RRM_1 PF00076.22 CDF40170.1 - 1.7e-38 130.2 0.0 4.6e-18 64.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDF40170.1 - 0.00091 19.2 0.0 0.88 9.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 CDF40170.1 - 0.031 13.9 0.0 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 CDF40170.1 - 0.038 13.6 0.0 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 CDF40170.1 - 0.039 14.1 0.0 0.23 11.6 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif RRM_3 PF08777.11 CDF40170.1 - 0.11 12.6 0.0 4.6 7.3 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif Limkain-b1 PF11608.8 CDF40170.1 - 0.2 11.8 0.1 9.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 Ribosomal_L21e PF01157.18 CDF40171.1 - 4e-38 129.3 3.3 5.9e-38 128.8 3.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e WD40 PF00400.32 CDF40172.1 - 2.7e-08 34.3 4.9 0.95 10.4 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40172.1 - 0.00061 20.0 0.5 0.2 12.0 0.2 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDF40172.1 - 0.008 16.1 0.2 0.048 13.6 0.1 2.2 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Ldh_2 PF02615.14 CDF40173.1 - 7.2e-105 350.8 0.1 8.1e-105 350.6 0.1 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Rhodanese PF00581.20 CDF40174.1 - 2.6e-14 53.6 0.0 4.9e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain FAD_binding_4 PF01565.23 CDF40175.1 - 1.4e-31 109.1 1.9 2.4e-19 69.5 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain BBE PF08031.12 CDF40175.1 - 0.00043 20.3 0.6 0.00097 19.2 0.6 1.6 1 0 0 1 1 1 1 Berberine and berberine like tRNA-synt_1e PF01406.19 CDF40176.1 - 7.7e-44 150.2 0.1 1e-43 149.9 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Helitron_like_N PF14214.6 CDF40177.1 - 5.2e-09 36.6 0.3 9.3e-09 35.8 0.3 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus DUF3584 PF12128.8 CDF40178.1 - 0.018 12.6 21.5 0.027 12.0 21.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 CDF40178.1 - 0.04 13.9 26.1 0.043 13.8 23.8 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 CDF40178.1 - 0.082 12.3 10.0 0.15 11.3 10.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PLAC9 PF15205.6 CDF40178.1 - 0.089 13.2 0.1 0.75 10.2 0.0 2.3 2 0 0 2 2 2 0 Placenta-specific protein 9 DUF4389 PF14333.6 CDF40178.1 - 0.13 12.2 2.0 0.34 10.9 2.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) FAM184 PF15665.5 CDF40178.1 - 0.78 9.5 26.6 1.4 8.6 26.6 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B TPR_MLP1_2 PF07926.12 CDF40178.1 - 1.2 9.2 28.1 3.7 7.6 27.9 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.19 CDF40178.1 - 1.5 6.6 10.1 2.4 6.0 10.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HlyIII PF03006.20 CDF40178.1 - 1.9 8.1 6.8 3.8 7.2 6.8 1.5 1 0 0 1 1 1 0 Haemolysin-III related Golgin_A5 PF09787.9 CDF40178.1 - 1.9 7.9 20.3 4 6.8 20.3 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 Asp-B-Hydro_N PF05279.11 CDF40178.1 - 2.1 8.4 20.9 3.4 7.7 20.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region UPF0242 PF06785.11 CDF40178.1 - 3.3 7.8 24.4 0.43 10.7 19.9 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Muted PF14942.6 CDF40178.1 - 10 6.5 20.2 22 5.4 19.6 1.9 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Ldh_2 PF02615.14 CDF40179.1 - 2.8e-102 342.3 0.1 3.1e-102 342.1 0.1 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase zf-RING_2 PF13639.6 CDF40180.1 - 1.6e-09 38.0 11.7 2.8e-09 37.1 11.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDF40180.1 - 5.9e-09 35.5 8.6 1.1e-08 34.7 8.6 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 CDF40180.1 - 5.8e-06 26.5 7.7 1.1e-05 25.6 7.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDF40180.1 - 0.00052 19.8 11.2 0.00096 19.0 11.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF40180.1 - 0.015 15.2 11.7 0.025 14.4 11.7 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF40180.1 - 0.15 12.0 10.7 0.25 11.3 10.7 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 CDF40180.1 - 0.22 11.6 3.9 0.41 10.7 3.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 CDF40180.1 - 1.3 9.3 7.9 2.4 8.4 7.9 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CDF40180.1 - 1.9 8.2 9.6 2.9 7.6 9.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CDF40180.1 - 3 7.9 11.3 6.7 6.8 11.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 CDF40180.1 - 9.2 6.2 9.7 16 5.5 9.7 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Ribosomal_S8 PF00410.19 CDF40181.1 - 1.6e-20 73.3 0.0 2.3e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 TPR_12 PF13424.6 CDF40182.1 - 4e-16 59.1 20.1 2e-07 31.2 3.1 4.4 2 1 1 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40182.1 - 3.3e-13 48.8 13.6 0.011 15.5 0.0 6.5 7 0 0 7 7 7 4 Tetratricopeptide repeat CHAT PF12770.7 CDF40182.1 - 5.7e-11 42.4 0.0 1.1e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 CHAT domain TPR_2 PF07719.17 CDF40182.1 - 1e-10 40.9 14.4 0.00031 20.6 0.1 6.5 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDF40182.1 - 5e-10 38.9 14.0 0.016 15.0 0.7 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40182.1 - 2.9e-07 30.2 7.2 0.15 12.3 0.4 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDF40182.1 - 4.7e-07 29.4 8.1 0.16 12.1 0.1 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CDF40182.1 - 6.6e-06 25.7 7.8 2.6e-05 23.8 7.3 2.0 2 1 0 2 2 2 1 MalT-like TPR region NACHT PF05729.12 CDF40182.1 - 0.00035 20.5 0.0 0.0012 18.8 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 CDF40182.1 - 0.00081 19.8 0.0 0.002 18.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SNAP PF14938.6 CDF40182.1 - 0.00095 18.7 7.8 0.00095 18.7 7.8 2.0 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP NB-ARC PF00931.22 CDF40182.1 - 0.001 18.3 0.0 0.0098 15.1 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 CDF40182.1 - 0.0024 18.2 0.0 0.008 16.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF40182.1 - 0.011 16.1 0.0 0.051 14.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain TPR_14 PF13428.6 CDF40182.1 - 0.035 14.9 8.2 5.1 8.2 0.0 5.2 3 1 2 5 5 4 0 Tetratricopeptide repeat ATPase_2 PF01637.18 CDF40182.1 - 0.045 13.7 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CDF40182.1 - 0.095 12.7 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sel1 PF08238.12 CDF40182.1 - 0.24 12.2 3.5 21 6.0 0.2 4.4 4 0 0 4 4 4 0 Sel1 repeat MIT PF04212.18 CDF40182.1 - 0.24 11.5 3.5 5.1 7.2 0.1 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain zf-C2H2 PF00096.26 CDF40183.1 - 2.6 8.7 14.3 1.5 9.5 1.8 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type Phage_ABA_S PF18066.1 CDF40186.1 - 0.29 11.9 1.7 5 7.9 0.3 2.0 1 1 1 2 2 2 0 Phage ABA sandwich domain DUF5613 PF18467.1 CDF40188.1 - 0.075 13.5 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5613) DEAD PF00270.29 CDF40189.1 - 6e-21 75.0 0.0 1.8e-20 73.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF40189.1 - 1.1e-17 64.3 0.1 2.4e-17 63.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF40189.1 - 0.00072 19.6 0.0 0.0023 18.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDF40189.1 - 0.02 15.1 0.9 0.79 10.0 0.3 3.1 2 1 0 2 2 2 0 AAA domain Flavi_DEAD PF07652.14 CDF40189.1 - 0.038 14.0 0.0 0.12 12.3 0.0 2.0 2 1 0 2 2 2 0 Flavivirus DEAD domain WD40 PF00400.32 CDF40191.1 - 3.3e-07 30.9 1.3 0.00059 20.6 0.5 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40191.1 - 0.0014 18.9 0.1 0.084 13.2 0.0 2.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CDF40191.1 - 0.0046 17.4 1.0 35 5.1 0.0 3.5 3 0 0 3 3 3 1 PQQ-like domain CPSF_A PF03178.15 CDF40191.1 - 0.014 14.8 0.1 0.021 14.2 0.1 1.3 1 1 0 1 1 1 0 CPSF A subunit region PALB2_WD40 PF16756.5 CDF40191.1 - 0.04 12.8 0.1 0.11 11.4 0.1 1.6 1 1 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain MPC PF03650.13 CDF40194.1 - 1.1e-34 118.8 0.0 1.2e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Snf7 PF03357.21 CDF40195.1 - 2.4e-09 37.0 6.7 4e-09 36.3 6.7 1.3 1 0 0 1 1 1 1 Snf7 DUF16 PF01519.16 CDF40195.1 - 0.013 16.0 3.6 0.026 15.0 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 MnmE_helical PF12631.7 CDF40195.1 - 0.019 15.1 3.4 0.049 13.8 3.3 1.8 1 1 0 1 1 1 0 MnmE helical domain F_actin_bund_C PF18060.1 CDF40195.1 - 0.02 15.0 0.6 0.02 15.0 0.6 2.3 2 1 0 2 2 1 0 F actin bundling C terminal RPW8 PF05659.11 CDF40195.1 - 0.026 14.2 1.0 6.1 6.5 0.1 2.6 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF285 PF03382.14 CDF40195.1 - 0.028 14.2 1.0 0.094 12.5 1.0 1.8 1 1 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 CK2S PF15011.6 CDF40195.1 - 0.034 14.0 1.2 0.051 13.5 1.2 1.3 1 0 0 1 1 1 0 Casein Kinase 2 substrate Fib_alpha PF08702.10 CDF40195.1 - 0.098 12.8 7.6 0.19 11.9 4.6 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 CDF40195.1 - 0.14 11.0 6.7 0.21 10.5 6.6 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Spectrin PF00435.21 CDF40195.1 - 0.14 12.7 4.9 0.59 10.6 4.2 2.4 1 1 2 3 3 3 0 Spectrin repeat NPV_P10 PF05531.12 CDF40195.1 - 0.16 12.5 8.1 9.3 6.8 7.5 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Retrotrans_gag PF03732.17 CDF40195.1 - 0.16 12.3 0.6 0.81 10.0 0.4 2.1 1 1 1 2 2 2 0 Retrotransposon gag protein DUF2730 PF10805.8 CDF40195.1 - 0.17 12.0 1.5 0.46 10.6 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) BORCS8 PF10167.9 CDF40195.1 - 0.21 11.5 4.3 5.3 7.0 0.1 2.2 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 Seryl_tRNA_N PF02403.22 CDF40195.1 - 0.39 11.0 9.8 4.5 7.6 0.2 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 CDF40195.1 - 0.43 10.6 9.6 8 6.5 8.0 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CorA PF01544.18 CDF40195.1 - 1.1 8.5 4.0 1.5 8.0 4.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4407 PF14362.6 CDF40195.1 - 1.5 8.1 9.6 1.6 8.0 8.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.6 CDF40195.1 - 1.9 9.0 9.0 1.9 9.0 1.1 2.7 2 1 0 2 2 2 0 Snapin/Pallidin XhlA PF10779.9 CDF40195.1 - 3.6 7.9 7.8 6.2 7.1 0.7 3.0 2 1 1 3 3 3 0 Haemolysin XhlA V_ATPase_I PF01496.19 CDF40195.1 - 3.9 5.3 5.7 12 3.7 5.9 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family MWFE PF15879.5 CDF40196.1 - 1.5e-10 41.0 0.1 2.5e-10 40.4 0.1 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Glucosamine_iso PF01182.20 CDF40197.1 - 1.5e-62 211.4 0.0 1.8e-62 211.1 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase WD40 PF00400.32 CDF40200.1 - 6.9e-29 99.5 11.7 8.4e-09 35.9 0.5 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat NB-ARC PF00931.22 CDF40200.1 - 2.3e-09 36.8 0.0 4.3e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF40200.1 - 1.2e-08 35.1 2.1 0.0054 17.0 0.2 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF40200.1 - 0.0032 16.5 0.0 0.77 8.7 0.0 3.0 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDF40200.1 - 0.007 16.8 4.8 2.1 8.9 0.1 3.9 1 1 3 4 4 4 2 PQQ-like domain Nup160 PF11715.8 CDF40200.1 - 0.046 12.4 3.7 15 4.1 0.1 3.6 1 1 3 4 4 4 0 Nucleoporin Nup120/160 APAF1_C PF17908.1 CDF40200.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 APAF-1 helical domain Cytochrom_D1 PF02239.16 CDF40200.1 - 0.31 9.5 4.0 0.75 8.3 1.1 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain AAA PF00004.29 CDF40203.1 - 9.2e-19 68.2 0.0 2.3e-18 66.9 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDF40203.1 - 0.00013 21.7 0.1 0.072 12.7 0.0 2.6 2 1 1 3 3 3 2 AAA domain AAA_22 PF13401.6 CDF40203.1 - 0.00028 21.2 0.1 0.0055 17.0 0.0 2.6 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 CDF40203.1 - 0.00036 20.3 0.0 0.0006 19.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF40203.1 - 0.00042 20.7 0.0 0.00083 19.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CDF40203.1 - 0.00072 19.1 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 CDF40203.1 - 0.00097 19.0 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.17 CDF40203.1 - 0.0039 16.3 0.0 0.0067 15.6 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 CDF40203.1 - 0.013 15.8 0.3 0.83 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDF40203.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zot PF05707.12 CDF40203.1 - 0.021 14.5 0.0 0.13 11.9 0.0 2.0 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) AAA_19 PF13245.6 CDF40203.1 - 0.057 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDF40203.1 - 0.074 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 CDF40203.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF40203.1 - 0.15 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDF40203.1 - 0.2 11.6 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain HPPK PF01288.20 CDF40204.1 - 8e-32 110.1 0.0 1.5e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Pterin_bind PF00809.22 CDF40204.1 - 2e-27 96.4 0.4 3.5e-27 95.7 0.4 1.4 1 0 0 1 1 1 1 Pterin binding enzyme Hydrolase PF00702.26 CDF40205.1 - 1.1e-10 42.2 0.5 7.1e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF40205.1 - 0.00025 20.9 0.1 0.045 13.5 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDF40205.1 - 0.0047 17.3 0.1 1 9.7 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDF40205.1 - 0.052 13.7 0.0 0.11 12.6 0.0 1.8 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF4392 PF14336.6 CDF40205.1 - 0.06 12.8 0.2 0.094 12.1 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4392) DUF2781 PF10914.8 CDF40209.1 - 0.022 15.1 1.2 0.022 15.1 1.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) AAA PF00004.29 CDF40211.1 - 9.9e-19 68.1 0.0 3.3e-18 66.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDF40211.1 - 0.0003 20.4 0.2 0.14 11.7 0.0 2.8 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 CDF40211.1 - 0.00035 21.0 0.0 0.0011 19.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CDF40211.1 - 0.00038 20.3 0.0 0.00067 19.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 CDF40211.1 - 0.001 18.6 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 CDF40211.1 - 0.0011 18.8 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDF40211.1 - 0.0011 19.2 0.1 0.013 15.8 0.0 2.6 3 1 1 4 4 3 1 AAA domain Parvo_NS1 PF01057.17 CDF40211.1 - 0.013 14.7 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_5 PF07728.14 CDF40211.1 - 0.016 15.2 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zot PF05707.12 CDF40211.1 - 0.042 13.5 0.0 0.38 10.4 0.0 2.4 2 1 1 3 3 3 0 Zonular occludens toxin (Zot) AAA_19 PF13245.6 CDF40211.1 - 0.087 13.2 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDF40211.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 CDF40211.1 - 0.16 12.2 0.2 1.4 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain MRP-L51 PF10244.9 CDF40213.1 - 0.18 12.1 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit Branch PF02485.21 CDF40214.1 - 5.1e-30 104.8 0.0 8.6e-30 104.0 0.0 1.3 1 1 0 1 1 1 1 Core-2/I-Branching enzyme ANAPC4_WD40 PF12894.7 CDF40215.1 - 1.4e-06 28.5 0.0 1.1 9.6 0.0 5.3 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40215.1 - 2.9e-06 27.9 3.4 0.88 10.5 0.0 6.8 7 0 0 7 7 7 1 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 CDF40215.1 - 0.0009 18.6 0.2 4 6.6 0.0 3.5 3 1 1 4 4 4 3 Rab3 GTPase-activating protein regulatory subunit N-terminus Hira PF07569.11 CDF40215.1 - 0.01 15.6 0.0 1.7 8.3 0.0 3.2 3 0 0 3 3 3 0 TUP1-like enhancer of split VCBS PF13517.6 CDF40215.1 - 0.19 12.4 0.0 7.8 7.2 0.0 3.0 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Syntaxin PF00804.25 CDF40216.1 - 5.1e-29 101.4 11.5 6.8e-29 101.0 11.5 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 CDF40216.1 - 5.7e-15 55.0 4.4 6.9e-14 51.6 0.3 3.4 3 0 0 3 3 3 1 SNARE domain SBP_bac_3 PF00497.20 CDF40216.1 - 0.083 12.3 0.0 2.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 T2SSF PF00482.23 CDF40216.1 - 0.084 12.8 4.7 1.9 8.5 0.2 2.9 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F DUF3139 PF11337.8 CDF40216.1 - 0.12 13.1 0.5 0.35 11.6 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF5345 PF17280.2 CDF40216.1 - 0.18 11.8 0.8 1.9 8.5 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Syntaxin_2 PF14523.6 CDF40216.1 - 0.29 11.5 12.8 0.23 11.9 2.5 3.2 2 1 1 3 3 3 0 Syntaxin-like protein DUF16 PF01519.16 CDF40216.1 - 3 8.4 9.9 2.9 8.4 0.5 2.8 1 1 0 2 2 2 0 Protein of unknown function DUF16 DUF2207 PF09972.9 CDF40216.1 - 6.5 5.4 6.8 3.9 6.1 0.1 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) FapA PF03961.13 CDF40216.1 - 8.7 4.8 14.1 1.4 7.5 4.0 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A bZIP_2 PF07716.15 CDF40222.1 - 2.9e-07 30.5 15.4 3.3e-07 30.3 8.6 2.6 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CDF40222.1 - 5.3e-06 26.4 12.0 5.9e-06 26.3 9.0 2.2 1 1 1 2 2 2 2 bZIP transcription factor bZIP_Maf PF03131.17 CDF40222.1 - 0.0014 19.1 10.9 0.0032 18.0 10.9 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor TSC22 PF01166.18 CDF40222.1 - 0.061 13.6 1.8 4.5 7.7 3.7 2.5 1 1 2 3 3 3 0 TSC-22/dip/bun family Atg14 PF10186.9 CDF40222.1 - 0.079 12.0 2.6 0.13 11.4 2.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 CDF40222.1 - 0.72 10.5 6.0 0.56 10.9 0.7 2.4 1 1 1 2 2 2 0 Initiation control protein YabA CorA PF01544.18 CDF40222.1 - 7.8 5.7 6.4 12 5.1 6.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein AAA PF00004.29 CDF40223.1 - 1.5e-40 138.7 0.0 2.4e-40 138.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDF40223.1 - 1.1e-10 41.3 0.6 2.1e-10 40.4 0.1 1.7 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CDF40223.1 - 1.9e-08 33.9 0.3 3.6e-08 33.1 0.3 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CDF40223.1 - 8.3e-06 26.0 0.0 1.6e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDF40223.1 - 1.2e-05 25.6 0.4 0.01 16.1 0.1 2.4 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 CDF40223.1 - 4.5e-05 22.8 0.0 7.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CDF40223.1 - 0.00016 22.1 0.1 0.0011 19.4 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CDF40223.1 - 0.00019 21.5 0.4 0.00069 19.6 0.1 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDF40223.1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 CDF40223.1 - 0.0044 16.4 0.3 0.21 10.9 0.1 2.3 1 1 0 2 2 2 1 KaiC AAA_18 PF13238.6 CDF40223.1 - 0.0055 17.2 0.1 0.056 14.0 0.0 2.4 2 1 1 3 3 2 1 AAA domain IstB_IS21 PF01695.17 CDF40223.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CDF40223.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_3 PF07726.11 CDF40223.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Prot_ATP_OB_N PF17758.1 CDF40223.1 - 0.021 14.4 0.1 0.07 12.8 0.0 1.9 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain RNA_helicase PF00910.22 CDF40223.1 - 0.033 14.6 0.0 0.068 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 CDF40223.1 - 0.046 13.6 0.1 0.25 11.2 0.0 2.1 1 1 1 2 2 2 0 NACHT domain AAA_25 PF13481.6 CDF40223.1 - 0.059 12.9 0.6 1 8.9 0.2 2.4 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 CDF40223.1 - 0.063 13.0 0.2 0.17 11.6 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDF40223.1 - 0.064 13.5 0.2 0.38 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CDF40223.1 - 0.065 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 CDF40223.1 - 0.082 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 CDF40223.1 - 0.088 12.3 0.0 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 CDF40223.1 - 0.092 12.2 0.1 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 CDF40223.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDF40223.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 CDF40223.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain FAD_binding_4 PF01565.23 CDF40225.1 - 2e-25 89.2 0.0 3.3e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 CDF40225.1 - 4.9e-16 59.3 0.2 9.1e-16 58.5 0.2 1.4 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Pkinase PF00069.25 CDF40227.1 - 2.3e-56 191.1 0.0 3.1e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40227.1 - 9.8e-25 87.3 0.0 1.3e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF40227.1 - 4.8e-06 26.1 0.0 2.2e-05 23.9 0.0 2.1 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDF40227.1 - 0.022 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF40227.1 - 0.025 14.5 0.0 0.056 13.4 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Uma2 PF05685.12 CDF40232.1 - 4.1e-22 78.5 0.0 6.7e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease UPF0242 PF06785.11 CDF40232.1 - 0.00044 20.4 2.8 0.00066 19.8 2.8 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Phage_GP20 PF06810.11 CDF40232.1 - 0.013 15.3 4.9 0.02 14.7 4.9 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 FAM76 PF16046.5 CDF40232.1 - 0.045 13.1 5.6 0.07 12.5 5.6 1.2 1 0 0 1 1 1 0 FAM76 protein DUF3552 PF12072.8 CDF40232.1 - 0.067 12.6 10.8 0.11 12.0 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) SLT PF01464.20 CDF40233.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain TENA_THI-4 PF03070.16 CDF40236.1 - 3.6e-06 26.9 0.0 1e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 TENA/THI-4/PQQC family Trypsin PF00089.26 CDF40237.1 - 6.7e-27 94.7 0.0 1e-26 94.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDF40237.1 - 2.5e-05 25.2 0.0 6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DDE_3 PF13358.6 CDF40241.1 - 2.8e-11 43.4 0.0 4.1e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease TIR_2 PF13676.6 CDF40243.1 - 5.3e-17 62.5 0.0 1e-16 61.6 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF40243.1 - 9.2e-09 35.3 0.0 1.7e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR-like PF10137.9 CDF40243.1 - 0.031 14.2 0.0 0.062 13.3 0.0 1.5 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Glyco_hydro_45 PF02015.16 CDF40244.1 - 1.2e-15 58.0 7.5 7e-15 55.5 3.5 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 45 DNA_pol_B PF00136.21 CDF40250.1 - 2.8e-114 382.3 0.0 3.7e-114 382.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDF40250.1 - 5.5e-26 91.5 0.0 2.8e-25 89.2 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 CDF40250.1 - 2.5e-22 79.5 0.0 4.3e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_2 PF03175.13 CDF40250.1 - 0.033 13.1 0.0 0.2 10.5 0.0 1.9 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral Sel1 PF08238.12 CDF40252.1 - 1.1e-80 264.2 13.5 1.2e-06 28.9 0.3 13.8 14 0 0 14 14 14 13 Sel1 repeat TPR_6 PF13174.6 CDF40252.1 - 2.5e-11 43.4 9.2 2.1 9.2 0.0 10.2 11 1 1 12 12 12 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40252.1 - 4.1e-07 30.5 21.8 3.4 8.4 0.9 9.6 6 4 4 10 10 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40252.1 - 6.3e-07 29.3 0.5 6.4 7.4 0.0 8.9 11 1 1 12 12 11 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF40252.1 - 1.2e-06 28.1 18.3 2.2 8.5 0.0 11.0 11 1 1 12 12 12 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40252.1 - 0.00014 21.5 15.6 3.7 7.5 0.1 9.4 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_5 PF12688.7 CDF40252.1 - 0.00026 21.2 7.9 6.2 7.1 0.0 6.7 7 1 1 8 8 8 1 Tetratrico peptide repeat TPR_14 PF13428.6 CDF40252.1 - 0.002 18.8 21.2 39 5.4 0.0 9.3 7 1 2 9 9 9 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF40252.1 - 0.016 15.3 17.5 9.4 6.6 0.0 9.5 11 0 0 11 11 10 0 Tetratricopeptide repeat SNAP PF14938.6 CDF40252.1 - 0.1 12.0 2.9 20 4.5 0.1 4.5 4 2 1 5 5 5 0 Soluble NSF attachment protein, SNAP DUF4205 PF13898.6 CDF40252.1 - 0.11 11.4 0.0 0.36 9.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4205) TPR_12 PF13424.6 CDF40252.1 - 0.13 12.6 20.8 2.9 8.2 0.0 8.5 8 2 1 10 10 9 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40252.1 - 0.13 12.8 25.6 12 6.5 0.2 9.0 9 2 1 10 10 9 0 Tetratricopeptide repeat PPR_long PF17177.4 CDF40252.1 - 0.15 11.4 1.8 36 3.6 0.0 4.6 4 1 0 6 6 6 0 Pentacotripeptide-repeat region of PRORP TPR_11 PF13414.6 CDF40252.1 - 0.41 10.4 9.6 47 3.8 0.0 6.3 7 0 0 7 7 7 0 TPR repeat Ldh_1_C PF02866.18 CDF40254.1 - 8.8e-33 113.6 0.0 2.1e-32 112.4 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CDF40254.1 - 2.2e-31 108.8 0.0 3.2e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Complex1_LYR_2 PF13233.6 CDF40255.1 - 3e-05 24.7 0.4 8.9e-05 23.2 0.4 1.9 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CDF40255.1 - 0.00033 20.6 0.1 0.001 19.1 0.1 1.9 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Phage_tail_APC PF16778.5 CDF40255.1 - 0.0029 17.4 0.0 0.07 13.0 0.0 2.6 2 0 0 2 2 2 1 Phage tail assembly chaperone protein RRF_GI PF12614.8 CDF40255.1 - 0.028 14.6 0.3 0.053 13.7 0.3 1.4 1 0 0 1 1 1 0 Ribosome recycling factor DAD PF02109.16 CDF40256.1 - 8.1e-37 125.9 0.7 9.3e-37 125.7 0.7 1.0 1 0 0 1 1 1 1 DAD family DJ-1_PfpI PF01965.24 CDF40258.1 - 7e-39 133.3 0.2 8.2e-39 133.0 0.2 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 CDF40258.1 - 0.044 13.4 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DUF711 PF05167.12 CDF40259.1 - 9.2e-39 133.5 0.1 2e-38 132.4 0.1 1.5 1 1 0 1 1 1 1 Uncharacterised ACR (DUF711) RINT1_TIP1 PF04437.13 CDF40260.1 - 1.9e-12 46.9 0.0 2.1e-09 36.8 0.0 3.7 2 1 0 2 2 2 2 RINT-1 / TIP-1 family BRCC36_C PF18110.1 CDF40260.1 - 0.038 14.1 0.4 0.12 12.6 0.4 1.8 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain NT-C2 PF10358.9 CDF40261.1 - 8.8e-10 38.5 0.4 8.8e-10 38.5 0.4 1.9 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins HALZ PF02183.18 CDF40261.1 - 0.036 14.3 7.3 1.5 9.1 0.8 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 CDF40261.1 - 0.043 14.2 1.7 0.043 14.2 1.7 3.6 2 1 0 2 2 2 0 Cell division protein ZapB SPX PF03105.19 CDF40261.1 - 0.064 13.2 12.3 0.095 12.6 12.3 1.3 1 0 0 1 1 1 0 SPX domain DUF948 PF06103.11 CDF40261.1 - 0.091 13.0 0.5 0.091 13.0 0.5 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DivIC PF04977.15 CDF40261.1 - 0.21 11.4 14.7 0.19 11.5 1.5 3.2 3 0 0 3 3 3 0 Septum formation initiator TPR_MLP1_2 PF07926.12 CDF40261.1 - 0.24 11.5 17.7 0.029 14.4 10.3 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 CDF40261.1 - 0.4 9.5 16.4 0.095 11.6 12.4 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein GIT_CC PF16559.5 CDF40261.1 - 0.57 10.1 8.7 8.3 6.4 1.8 3.4 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4407 PF14362.6 CDF40261.1 - 1.3 8.3 11.6 1.9 7.8 11.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TolA_bind_tri PF16331.5 CDF40261.1 - 1.9 8.7 0.0 1.9 8.7 0.0 3.1 4 0 0 4 4 3 0 TolA binding protein trimerisation UPF0242 PF06785.11 CDF40261.1 - 4.5 7.3 15.9 38 4.3 14.7 2.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 CDF40261.1 - 6.1 7.2 13.6 0.18 12.1 4.1 2.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FliJ PF02050.16 CDF40261.1 - 6.2 7.1 11.0 1.7 8.9 3.1 2.6 2 1 0 2 2 2 0 Flagellar FliJ protein SlyX PF04102.12 CDF40261.1 - 9.7 6.9 10.9 1.7 9.3 1.3 3.5 1 1 1 3 3 3 0 SlyX NTP_transferase PF00483.23 CDF40263.1 - 4.5e-51 173.8 0.0 5.8e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDF40263.1 - 7.6e-11 42.6 0.0 1.2e-10 42.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 CDF40263.1 - 8.8e-10 37.9 8.5 3.2e-07 29.8 2.7 3.3 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDF40263.1 - 0.0021 17.8 3.8 0.014 15.1 4.1 2.2 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase IspD PF01128.19 CDF40263.1 - 0.022 14.5 0.0 0.067 12.9 0.0 1.8 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 CDF40263.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase Pro_CA PF00484.19 CDF40264.1 - 1.3e-34 119.8 1.1 1.6e-34 119.5 1.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase FlaC_arch PF05377.11 CDF40264.1 - 0.09 13.2 0.5 18 5.8 0.0 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) OAM_alpha PF16552.5 CDF40264.1 - 0.13 12.2 0.3 0.23 11.3 0.3 1.4 1 0 0 1 1 1 0 D-ornithine 4,5-aminomutase alpha-subunit zf-C2H2 PF00096.26 CDF40266.1 - 0.014 15.8 2.8 0.044 14.3 2.8 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF40266.1 - 1.3 10.1 5.2 0.49 11.4 2.2 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger PHD PF00628.29 CDF40268.1 - 1.5e-09 37.5 5.1 1.5e-09 37.5 5.1 2.6 2 0 0 2 2 2 1 PHD-finger DZR PF12773.7 CDF40268.1 - 0.046 13.7 0.2 0.046 13.7 0.2 4.0 3 1 0 3 3 3 0 Double zinc ribbon C1_1 PF00130.22 CDF40268.1 - 0.13 12.1 15.4 0.27 11.2 0.8 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GidB PF02527.15 CDF40271.1 - 1.3e-34 119.2 0.0 2.4e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MTS PF05175.14 CDF40271.1 - 0.0098 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDF40271.1 - 0.093 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Glycos_transf_1 PF00534.20 CDF40273.1 - 7e-36 123.3 0.0 1e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDF40273.1 - 9.7e-18 64.9 0.0 1.5e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDF40273.1 - 1e-11 45.1 0.0 1.6e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDF40273.1 - 9.8e-08 32.3 0.0 2.9e-07 30.8 0.0 1.8 1 1 1 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDF40273.1 - 1.6e-07 31.9 0.3 2.9e-07 31.1 0.3 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 CDF40273.1 - 0.35 10.9 1.3 23 4.9 1.6 3.0 2 1 0 2 2 2 0 ALG11 mannosyltransferase N-terminus Calreticulin PF00262.18 CDF40274.1 - 3.6e-137 457.1 8.9 5e-137 456.7 8.9 1.2 1 0 0 1 1 1 1 Calreticulin family CLN3 PF02487.17 CDF40274.1 - 0.067 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 CLN3 protein ETRAMP PF09716.10 CDF40275.1 - 0.92 9.6 4.1 0.68 10.0 3.2 1.2 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Glyco_hydro_16 PF00722.21 CDF40276.1 - 7.8e-15 54.8 0.8 1.3e-14 54.0 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF3729 PF12526.8 CDF40276.1 - 5.2 8.7 12.1 0.3 12.6 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3729) Glyco_transf_20 PF00982.21 CDF40277.1 - 1.5e-139 465.8 0.0 1.9e-139 465.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CDF40277.1 - 3.2e-56 190.1 0.0 6.7e-56 189.0 0.0 1.6 2 0 0 2 2 2 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 CDF40277.1 - 0.00058 19.7 0.0 0.0019 18.0 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDF40277.1 - 0.16 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Malectin PF11721.8 CDF40280.1 - 3.5e-15 56.5 0.0 5.1e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Malectin domain ICMT PF04140.14 CDF40284.1 - 4.1e-25 88.0 1.1 4.1e-25 88.0 1.1 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CDF40284.1 - 1.4e-07 31.8 1.2 1.7e-07 31.6 0.2 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 CDF40284.1 - 0.00054 19.5 0.9 0.00075 19.1 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) TRAM_LAG1_CLN8 PF03798.16 CDF40285.1 - 8.6e-18 64.8 11.2 8.6e-18 64.8 11.2 1.6 2 1 0 2 2 2 1 TLC domain UQ_con PF00179.26 CDF40286.1 - 1.8e-23 82.8 0.0 3.1e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme CDC48_N PF02359.18 CDF40286.1 - 0.0027 17.9 0.5 0.028 14.6 0.2 2.5 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain DUF4537 PF15057.6 CDF40286.1 - 0.0059 16.6 0.5 0.13 12.3 0.2 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4537) Cul7 PF11515.8 CDF40286.1 - 0.12 12.7 0.0 16 5.8 0.0 2.6 2 0 0 2 2 2 0 Mouse development and cellular proliferation protein Cullin-7 NAD_binding_1 PF00175.21 CDF40288.1 - 5.2e-09 36.7 0.0 1.1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Putative_PNPOx PF01243.20 CDF40288.1 - 7.8e-07 29.2 0.0 1e-05 25.6 0.0 2.3 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 CDF40288.1 - 2.8e-05 24.4 0.0 5.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CDF40288.1 - 0.0045 17.1 0.0 0.04 14.0 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 CDF40288.1 - 0.064 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain GST_N_3 PF13417.6 CDF40289.1 - 7.2e-10 39.1 0.0 2.3e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CDF40289.1 - 1.9e-07 31.2 0.4 3.8e-07 30.2 0.4 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_4 PF17172.4 CDF40289.1 - 1e-05 26.2 0.0 3.1e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_N_2 PF13409.6 CDF40289.1 - 4.7e-05 23.6 0.0 0.00012 22.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDF40289.1 - 0.0055 17.0 0.1 0.016 15.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDF40289.1 - 0.033 14.2 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDF40289.1 - 0.036 14.3 0.0 0.082 13.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CDF40289.1 - 0.12 12.1 0.0 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain HSP20 PF00011.21 CDF40291.1 - 6.6e-13 48.7 0.4 8.9e-11 41.9 0.4 2.1 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDF40291.1 - 3e-05 23.5 0.0 5.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA TamB PF04357.13 CDF40291.1 - 0.16 11.2 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex HSP20 PF00011.21 CDF40293.1 - 7.6e-14 51.7 0.4 2.1e-13 50.3 0.4 1.6 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDF40293.1 - 0.00017 21.1 0.1 0.00085 18.8 0.1 2.0 1 1 1 2 2 2 1 HSP20-like domain found in ArsA ABC_membrane_2 PF06472.15 CDF40294.1 - 1.1e-49 169.3 5.1 1.4e-49 169.0 5.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDF40294.1 - 9.9e-19 68.2 0.0 1.6e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SbmA_BacA PF05992.12 CDF40294.1 - 2.1e-10 40.6 3.1 8.1e-10 38.6 3.1 1.8 1 1 0 1 1 1 1 SbmA/BacA-like family AAA_25 PF13481.6 CDF40294.1 - 7.4e-06 25.7 1.4 0.1 12.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CDF40294.1 - 8.6e-05 22.3 0.0 0.00043 20.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain ABC_membrane PF00664.23 CDF40294.1 - 0.00029 20.6 4.4 0.0006 19.6 4.4 1.5 1 1 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDF40294.1 - 0.0043 16.5 0.1 1 8.7 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CDF40294.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 CDF40294.1 - 0.014 15.4 0.0 0.037 14.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF40294.1 - 0.022 14.7 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Rnk_N PF14760.6 CDF40294.1 - 0.082 13.4 0.1 0.24 11.9 0.1 1.8 1 0 0 1 1 1 0 Rnk N-terminus AAA_29 PF13555.6 CDF40294.1 - 0.13 12.1 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CDF40294.1 - 0.17 12.1 0.8 0.65 10.3 0.3 2.3 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDF40294.1 - 0.18 12.2 4.3 0.12 12.7 0.5 2.6 1 1 1 2 2 2 0 AAA ATPase domain FA_hydroxylase PF04116.13 CDF40295.1 - 4.8e-25 88.4 16.2 4.8e-25 88.4 16.2 2.3 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily HSP20 PF00011.21 CDF40296.1 - 4.3e-12 46.1 0.1 5.4e-05 23.3 0.0 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDF40296.1 - 9.2e-05 21.9 0.0 0.0002 20.8 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 CDF40297.1 - 0.00077 19.6 0.1 0.0011 19.1 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDF40297.1 - 0.025 14.1 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 HSP20-like domain found in ArsA Peptidase_M10_C PF08548.11 CDF40297.1 - 0.16 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase M10 serralysin C terminal WD40 PF00400.32 CDF40299.1 - 5.8e-23 80.7 6.5 0.00016 22.4 0.0 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat PRP4 PF08799.11 CDF40299.1 - 5.1e-10 38.7 2.3 1.6e-09 37.2 2.3 1.9 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 CDF40299.1 - 1.7e-05 25.0 0.2 0.77 10.1 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF40299.1 - 0.18 11.7 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CDF40302.1 - 0.025 14.4 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRKCSH-like PF12999.7 CDF40302.1 - 0.74 9.6 4.2 1.1 9.0 4.2 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Macoilin PF09726.9 CDF40302.1 - 2 6.9 6.7 2.7 6.5 6.7 1.1 1 0 0 1 1 1 0 Macoilin family Atg14 PF10186.9 CDF40302.1 - 3.1 6.8 4.8 4.4 6.3 4.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 C2 PF00168.30 CDF40303.1 - 2e-16 60.2 0.0 1.2e-07 32.0 0.0 5.0 5 0 0 5 5 5 3 C2 domain PWWP PF00855.17 CDF40304.1 - 3.9e-23 81.7 0.8 2.1e-10 40.9 0.0 3.0 2 1 0 2 2 2 2 PWWP domain SET PF00856.28 CDF40304.1 - 8.9e-19 68.5 0.6 4.4e-18 66.2 0.6 2.1 1 1 0 1 1 1 1 SET domain AWS PF17907.1 CDF40304.1 - 0.0041 17.1 5.6 0.0041 17.1 5.6 2.8 3 0 0 3 3 3 1 AWS domain Agenet PF05641.12 CDF40304.1 - 0.012 16.0 0.2 0.035 14.6 0.2 1.8 1 0 0 1 1 1 0 Agenet domain Tudor_3 PF18115.1 CDF40304.1 - 0.06 13.2 0.6 1.1 9.2 0.5 2.4 1 1 1 2 2 2 0 DNA repair protein Crb2 Tudor domain NQRA PF05896.11 CDF40306.1 - 0.039 13.4 0.0 0.039 13.4 0.0 1.0 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) Ribosomal_L28e PF01778.17 CDF40307.1 - 9e-18 65.1 0.0 1.1e-17 64.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Ribosomal_L27A PF00828.19 CDF40308.1 - 1.6e-27 96.7 0.8 2.4e-27 96.1 0.8 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Colipase_C PF02740.14 CDF40309.1 - 0.00022 21.3 0.4 0.024 14.8 0.1 2.1 2 0 0 2 2 2 2 Colipase, C-terminal domain Amidinotransf PF02274.17 CDF40311.1 - 2.1e-55 188.2 1.0 8.7e-51 173.0 0.9 3.0 2 1 0 2 2 2 2 Amidinotransferase Branch PF02485.21 CDF40313.1 - 9e-40 136.7 1.8 1.2e-39 136.3 1.8 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Ribosomal_S3Ae PF01015.18 CDF40314.1 - 6.4e-90 300.1 2.2 7.6e-90 299.9 2.2 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 CDF40314.1 - 0.021 14.4 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Methyltransf_32 PF13679.6 CDF40315.1 - 4.8e-10 39.7 0.7 1.9e-09 37.7 0.7 1.9 1 1 0 1 1 1 1 Methyltransferase domain R3H PF01424.22 CDF40315.1 - 7.1e-09 35.5 0.0 1.4e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 R3H domain Methyltransf_25 PF13649.6 CDF40315.1 - 2.7e-06 28.0 0.2 6e-06 26.9 0.2 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF40315.1 - 1.9e-05 24.5 0.0 3.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF40315.1 - 0.00027 20.5 0.0 0.00045 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 CDF40315.1 - 0.0003 21.5 0.0 0.0006 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF40315.1 - 0.00062 19.2 0.0 0.0014 18.0 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CDF40315.1 - 0.0025 17.6 0.0 0.0041 16.9 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_4 PF02390.17 CDF40315.1 - 0.0027 17.2 0.1 0.009 15.5 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase TRM13 PF05206.14 CDF40315.1 - 0.026 14.1 0.2 3.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 Methyltransf_2 PF00891.18 CDF40315.1 - 0.027 13.8 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain GidB PF02527.15 CDF40315.1 - 0.047 13.0 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Glutaredoxin PF00462.24 CDF40316.1 - 4.9e-13 49.1 0.0 1.1e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin ELO PF01151.18 CDF40317.1 - 1e-45 156.3 20.7 1.3e-45 155.9 20.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family TPM_phosphatase PF04536.14 CDF40318.1 - 0.0022 18.1 0.0 0.003 17.7 0.0 1.2 1 0 0 1 1 1 1 TPM domain SHE3 PF17078.5 CDF40319.1 - 0.0013 18.5 11.0 0.0013 18.5 11.0 4.5 1 1 3 4 4 4 2 SWI5-dependent HO expression protein 3 KASH_CCD PF14662.6 CDF40319.1 - 0.002 18.0 62.1 0.32 10.8 7.9 5.2 1 1 3 4 4 4 3 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 CDF40319.1 - 0.011 16.3 86.3 0.064 13.8 2.4 6.7 1 1 6 7 7 7 0 Apg6 coiled-coil region HALZ PF02183.18 CDF40319.1 - 0.015 15.5 26.8 0.33 11.2 0.0 6.8 7 2 1 8 8 8 0 Homeobox associated leucine zipper Spc7 PF08317.11 CDF40319.1 - 1.5 7.6 69.7 0.23 10.3 15.2 4.1 1 1 3 4 4 4 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 CDF40319.1 - 5.9 6.3 59.1 0.083 12.3 21.4 3.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF726 PF05277.12 CDF40321.1 - 0.0046 15.9 0.0 0.0068 15.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Ser_hydrolase PF06821.13 CDF40321.1 - 0.19 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Cwf_Cwc_15 PF04889.12 CDF40321.1 - 1.5 8.5 6.3 2.1 8.0 6.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NMT PF01233.19 CDF40322.1 - 1.3e-22 80.4 0.1 1.3e-22 80.3 0.1 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Adaptin_N PF01602.20 CDF40323.1 - 1.4e-32 112.9 1.8 2e-32 112.5 1.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region DUF726 PF05277.12 CDF40325.1 - 0.15 11.0 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Ser_hydrolase PF06821.13 CDF40325.1 - 0.19 11.6 0.1 0.27 11.1 0.1 1.2 1 0 0 1 1 1 0 Serine hydrolase Adaptin_N PF01602.20 CDF40326.1 - 1.3e-106 357.3 0.2 1.8e-106 356.8 0.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CDF40326.1 - 1.1e-18 67.7 0.4 3.8e-17 62.8 0.2 3.0 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 AP3B1_C PF14796.6 CDF40326.1 - 2.3e-08 34.4 0.0 5.2e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal HEAT_2 PF13646.6 CDF40326.1 - 2.6e-05 24.5 18.2 0.00082 19.7 0.5 4.3 5 1 1 6 6 6 2 HEAT repeats Arm PF00514.23 CDF40326.1 - 9.5e-05 22.3 0.8 0.18 11.9 0.0 4.5 3 1 1 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CDF40326.1 - 0.0013 18.8 10.4 0.074 13.4 0.1 5.9 6 1 1 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 CDF40326.1 - 0.061 13.8 10.6 0.42 11.2 0.1 5.0 4 2 3 7 7 7 0 HEAT-like repeat PPR_2 PF13041.6 CDF40327.1 - 4.8e-38 129.1 8.7 8.4e-10 38.7 0.0 7.4 2 2 5 7 7 7 7 PPR repeat family PPR PF01535.20 CDF40327.1 - 2.6e-30 102.5 14.8 6.8e-05 22.9 0.3 8.3 8 0 0 8 8 8 6 PPR repeat PPR_1 PF12854.7 CDF40327.1 - 1.4e-22 79.1 0.5 0.00016 21.3 0.0 5.7 5 0 0 5 5 5 5 PPR repeat PPR_long PF17177.4 CDF40327.1 - 8.5e-18 64.5 10.0 3.3e-14 52.8 3.8 4.5 1 1 3 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 CDF40327.1 - 1.6e-17 63.3 5.1 2e-10 40.6 0.0 5.2 4 1 2 6 6 6 2 Pentatricopeptide repeat domain BTAD PF03704.17 CDF40327.1 - 0.0021 18.5 8.2 1.7 9.1 0.0 4.3 3 1 1 4 4 4 2 Bacterial transcriptional activator domain MRP-S27 PF10037.9 CDF40327.1 - 0.095 11.6 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 CPSase_L_D2 PF02786.17 CDF40330.1 - 4.8e-82 274.6 0.4 7.6e-82 273.9 0.4 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDF40330.1 - 2.6e-42 143.8 0.0 5.3e-42 142.8 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDF40330.1 - 5.5e-36 123.0 0.0 1.1e-35 122.0 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CDF40330.1 - 1.2e-10 41.2 0.0 2.8e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CDF40330.1 - 8.6e-10 38.5 0.2 2.8e-09 36.8 0.1 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CDF40330.1 - 0.00043 20.4 0.0 0.00085 19.4 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 CDF40330.1 - 0.0045 16.7 0.1 0.0084 15.9 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 CDF40330.1 - 0.022 14.2 0.1 0.067 12.6 0.1 1.8 1 1 0 1 1 1 0 ATP-grasp domain RimK PF08443.11 CDF40330.1 - 0.067 12.8 0.0 0.25 10.9 0.0 1.9 1 1 0 1 1 1 0 RimK-like ATP-grasp domain UCH PF00443.29 CDF40331.1 - 7.9e-43 146.8 0.4 1.2e-42 146.2 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 CDF40331.1 - 2.5e-28 99.0 0.0 5.3e-26 91.4 0.0 3.0 3 1 0 3 3 3 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 CDF40331.1 - 4.7e-28 98.3 0.0 3.2e-24 85.8 0.0 3.3 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH_1 PF13423.6 CDF40331.1 - 5.3e-21 75.5 0.1 2.7e-20 73.2 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 CDF40331.1 - 0.0018 18.4 1.0 2.5 8.3 0.0 3.3 4 0 0 4 4 4 2 MATH domain WD40 PF00400.32 CDF40332.1 - 1.8e-60 199.5 17.0 3.9e-11 43.3 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40332.1 - 8.9e-15 54.8 0.0 0.015 15.6 0.0 6.2 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF40332.1 - 1.1e-08 34.8 0.0 0.012 15.0 0.0 3.4 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 CDF40332.1 - 3.5e-06 26.0 0.1 0.035 12.8 0.0 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CDF40332.1 - 7.9e-06 24.6 0.0 0.083 11.4 0.1 2.5 2 1 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 CDF40332.1 - 0.00017 21.6 0.0 1.2 9.0 0.0 3.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDF40332.1 - 0.0006 18.9 0.0 3.6 6.5 0.0 4.2 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CDF40332.1 - 0.0024 17.8 0.2 26 4.9 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat RAB3GAP2_N PF14655.6 CDF40332.1 - 0.0039 16.5 0.0 0.073 12.3 0.0 2.3 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Nucleoporin_N PF08801.11 CDF40332.1 - 0.01 14.6 0.1 0.97 8.1 0.0 3.3 2 1 2 4 4 4 0 Nup133 N terminal like Proteasome_A_N PF10584.9 CDF40332.1 - 0.034 13.8 1.5 1.8 8.3 0.0 3.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 CDF40333.1 - 1.1e-57 190.7 18.1 2.1e-11 44.2 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40333.1 - 1.5e-14 54.1 0.4 0.021 15.1 0.0 6.3 1 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF40333.1 - 1.4e-09 37.7 0.0 0.01 15.2 0.0 3.9 4 0 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 CDF40333.1 - 1.7e-05 23.7 2.7 0.031 12.9 0.0 4.5 3 1 2 5 5 5 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CDF40333.1 - 7.3e-05 21.5 0.0 0.23 10.0 0.0 2.4 2 1 0 2 2 2 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 CDF40333.1 - 0.00014 20.9 0.0 3.5 6.5 0.0 4.2 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CDF40333.1 - 0.001 18.9 0.1 24 5.0 0.0 3.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 CDF40333.1 - 0.007 15.5 0.2 1 8.4 0.0 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF1513) eIF2A PF08662.11 CDF40333.1 - 0.014 15.2 0.0 0.81 9.5 0.0 3.0 1 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 CDF40333.1 - 0.018 14.7 0.2 2.4 7.9 0.0 3.3 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature zf-C3HC PF07967.13 CDF40335.1 - 2.5e-10 40.5 0.1 2.6e-09 37.2 0.0 2.4 2 0 0 2 2 2 1 C3HC zinc finger-like Rsm1 PF08600.10 CDF40335.1 - 0.03 14.5 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 Rsm1-like Paramyx_P_V_C PF03210.13 CDF40335.1 - 0.15 11.9 3.8 0.58 9.9 0.9 3.0 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal DUF2405 PF10293.9 CDF40335.1 - 0.27 11.2 0.7 0.57 10.1 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2405) SIR2 PF02146.17 CDF40336.1 - 8.5e-29 100.7 0.0 1.1e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TRAP-delta PF05404.12 CDF40336.1 - 0.0079 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) Oxidored_FMN PF00724.20 CDF40340.1 - 7.4e-73 245.8 0.0 8.5e-73 245.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ABC_tran PF00005.27 CDF40343.1 - 5.8e-34 117.5 0.0 9.2e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDF40343.1 - 5.6e-17 62.3 0.2 7.6e-17 61.8 0.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDF40343.1 - 4e-05 23.2 0.0 5.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CDF40343.1 - 0.0052 16.1 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin G-alpha PF00503.20 CDF40343.1 - 0.008 15.4 0.0 0.0096 15.1 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit AAA_22 PF13401.6 CDF40343.1 - 0.011 16.1 0.1 0.066 13.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 CDF40343.1 - 0.02 13.7 0.1 0.04 12.7 0.1 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class SbcCD_C PF13558.6 CDF40343.1 - 0.023 14.9 0.8 0.25 11.6 0.8 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 CDF40343.1 - 0.039 13.6 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CDF40343.1 - 0.085 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Tropomyosin_1 PF12718.7 CDF40345.1 - 0.01 16.0 14.5 0.01 16.0 14.5 2.5 1 1 1 2 2 2 0 Tropomyosin like DUF2703 PF10865.8 CDF40345.1 - 0.36 11.0 3.1 0.46 10.7 1.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2703) Branch PF02485.21 CDF40346.1 - 1.3e-27 96.9 0.0 2.1e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 Core-2/I-Branching enzyme CBS PF00571.28 CDF40347.1 - 3.7e-27 94.5 3.3 2.3e-09 37.5 0.1 4.7 4 0 0 4 4 4 4 CBS domain TPR_1 PF00515.28 CDF40347.1 - 1e-19 69.4 13.5 4.2e-05 23.2 0.2 5.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40347.1 - 8.7e-15 55.1 17.1 4.7e-07 30.3 0.2 4.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF40347.1 - 9.2e-14 50.4 24.3 0.00016 21.5 0.5 6.5 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDF40347.1 - 1.9e-12 46.6 14.7 1.9e-06 27.4 0.2 5.4 4 2 2 6 6 6 3 TPR repeat TPR_19 PF14559.6 CDF40347.1 - 1.4e-10 41.5 13.8 0.0063 17.0 0.3 4.8 2 2 2 4 4 4 3 Tetratricopeptide repeat PB1 PF00564.24 CDF40347.1 - 8.4e-10 38.5 0.0 2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 PB1 domain TPR_8 PF13181.6 CDF40347.1 - 7.6e-09 35.1 12.0 0.2 12.0 0.3 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDF40347.1 - 3.8e-08 33.5 11.2 0.0013 18.9 0.3 3.3 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40347.1 - 3.6e-07 30.4 23.9 0.016 16.0 0.7 6.3 5 2 2 7 7 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40347.1 - 1.9e-05 24.7 1.0 0.016 15.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF40347.1 - 2.6e-05 24.3 12.8 0.00013 22.0 2.3 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF40347.1 - 3.4e-05 24.0 0.9 0.64 10.3 0.0 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDF40347.1 - 0.00037 20.3 9.5 4.8 7.4 0.2 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40347.1 - 0.00052 20.5 9.8 2 9.2 0.1 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat NRBF2_MIT PF17169.4 CDF40347.1 - 0.079 13.2 2.4 4.2 7.7 0.1 3.2 3 0 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 TPR_21 PF09976.9 CDF40347.1 - 0.39 10.4 9.3 4 7.1 0.9 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain MIT PF04212.18 CDF40347.1 - 0.4 10.8 8.5 11 6.2 0.2 4.3 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 CDF40347.1 - 0.98 9.4 7.6 16 5.5 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 CDF40347.1 - 2.4 8.6 12.3 7.7 6.9 0.0 3.3 3 1 0 3 3 3 0 Bacterial transcriptional activator domain QRPTase_C PF01729.19 CDF40351.1 - 1.3e-46 158.4 1.2 1.9e-46 158.0 1.2 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CDF40351.1 - 6.4e-11 42.2 0.2 1.6e-10 40.9 0.2 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain LSDAT_prok PF18171.1 CDF40351.1 - 0.046 13.0 0.1 0.073 12.3 0.1 1.3 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote HEAT_UF PF18817.1 CDF40352.1 - 0.024 14.9 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 Repeat of uncharacterized protein PH0542 DUF4091 PF13320.6 CDF40354.1 - 0.034 14.3 0.0 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) Hydrolase PF00702.26 CDF40356.1 - 4.2e-13 50.1 0.7 6.9e-07 29.8 0.1 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF40356.1 - 0.00028 20.7 0.0 0.0032 17.2 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDF40356.1 - 0.0063 16.6 0.1 0.055 13.6 0.0 2.4 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase gag_pre-integrs PF13976.6 CDF40356.1 - 0.0084 15.9 0.1 0.89 9.5 0.0 2.4 2 0 0 2 2 2 1 GAG-pre-integrase domain Zeta_toxin PF06414.12 CDF40356.1 - 0.032 13.5 0.1 0.84 8.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Cation_ATPase PF13246.6 CDF40356.1 - 0.04 14.0 0.0 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Cation transport ATPase (P-type) Frag1 PF10277.9 CDF40357.1 - 0.46 10.0 3.0 0.52 9.8 3.0 1.1 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family DUF4233 PF14017.6 CDF40357.1 - 0.49 10.8 4.6 1 9.8 4.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4233) TFIIS_C PF01096.18 CDF40359.1 - 1.7e-17 63.0 7.5 1.7e-17 63.0 7.5 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Myticin-prepro PF10690.9 CDF40359.1 - 0.097 12.9 2.9 0.12 12.7 2.9 1.1 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Porin_3 PF01459.22 CDF40360.1 - 8.7e-42 143.4 8.5 1.1e-41 143.1 8.5 1.0 1 0 0 1 1 1 1 Eukaryotic porin Tail_tube PF10618.9 CDF40360.1 - 0.23 11.4 2.6 0.49 10.3 0.0 2.5 3 1 0 3 3 3 0 Phage tail tube protein LIM_bind PF01803.16 CDF40361.1 - 4.6e-22 78.7 0.0 3.4e-21 75.9 0.0 2.2 1 1 1 2 2 2 1 LIM-domain binding protein PRA1 PF03208.19 CDF40363.1 - 7.3e-23 80.8 11.2 8.9e-23 80.5 11.2 1.0 1 0 0 1 1 1 1 PRA1 family protein YqjK PF13997.6 CDF40363.1 - 0.072 13.3 0.8 0.072 13.3 0.8 2.4 3 0 0 3 3 3 0 YqjK-like protein CitMHS PF03600.16 CDF40363.1 - 0.31 10.2 10.5 0.37 9.9 10.5 1.0 1 0 0 1 1 1 0 Citrate transporter Amidinotransf PF02274.17 CDF40365.1 - 9.6e-10 38.1 0.0 7.1e-09 35.2 0.0 2.1 2 1 0 2 2 2 1 Amidinotransferase Cellulose_synt PF03552.14 CDF40366.1 - 2.6e-13 49.4 0.8 1e-08 34.2 0.8 2.1 1 1 1 2 2 2 2 Cellulose synthase Glyco_trans_2_3 PF13632.6 CDF40366.1 - 1.2e-12 48.1 1.1 1.2e-12 48.1 1.1 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CDF40366.1 - 6.3e-07 29.5 0.0 1e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CDF40366.1 - 0.017 14.6 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 Mito_carr PF00153.27 CDF40370.1 - 4e-61 203.0 6.8 1.8e-22 79.1 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Hepatitis_core PF00906.20 CDF40370.1 - 0.84 9.1 4.3 1.2 8.7 4.3 1.2 1 0 0 1 1 1 0 Hepatitis core antigen Pyr_redox_2 PF07992.14 CDF40371.1 - 2.7e-53 181.1 1.2 4.7e-53 180.3 1.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDF40371.1 - 6.1e-26 90.8 0.4 6.1e-26 90.8 0.4 2.2 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DEP PF00610.21 CDF40371.1 - 5.7e-20 71.2 0.0 1.2e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pyr_redox PF00070.27 CDF40371.1 - 1.1e-17 64.4 9.1 8.5e-17 61.5 0.2 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDF40371.1 - 1e-05 25.6 4.9 0.0064 16.7 0.8 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CDF40371.1 - 1e-05 24.9 6.3 3e-05 23.4 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF40371.1 - 1.1e-05 24.7 8.6 0.00064 18.9 6.0 2.5 2 1 0 2 2 2 2 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CDF40371.1 - 0.0007 19.0 0.7 0.022 14.1 0.0 2.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDF40371.1 - 0.00083 19.3 0.1 0.00083 19.3 0.1 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 CDF40371.1 - 0.0018 17.0 8.5 0.018 13.7 2.8 2.9 3 0 0 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.21 CDF40371.1 - 0.0041 16.4 10.5 0.019 14.3 0.0 3.1 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 CDF40371.1 - 0.0045 17.2 0.1 0.01 16.0 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 CDF40371.1 - 0.0059 16.2 4.2 1.2 8.7 0.3 2.8 2 1 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain K_oxygenase PF13434.6 CDF40371.1 - 0.0086 15.3 0.0 0.038 13.1 0.0 1.9 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 CDF40371.1 - 0.61 9.1 14.3 0.32 10.0 7.5 2.4 2 0 0 2 2 2 0 FAD binding domain FAD_oxidored PF12831.7 CDF40371.1 - 1.1 8.5 7.9 0.032 13.6 1.5 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase DAO PF01266.24 CDF40371.1 - 2 7.9 9.7 13 5.2 0.2 3.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase WD40 PF00400.32 CDF40373.1 - 1.1e-12 48.2 6.8 0.00012 22.8 0.4 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40373.1 - 0.0081 16.4 0.1 0.059 13.7 0.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CDF40373.1 - 0.011 14.3 0.5 0.013 14.0 0.5 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain CNF1 PF05785.12 CDF40373.1 - 0.025 13.9 0.4 0.29 10.3 0.1 1.9 1 1 1 2 2 2 0 Rho-activating domain of cytotoxic necrotizing factor Nup160 PF11715.8 CDF40373.1 - 0.063 11.9 0.0 0.91 8.1 0.1 1.9 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CDF40373.1 - 0.096 13.2 0.3 3.1 8.4 0.0 2.7 3 0 0 3 3 3 0 PQQ-like domain FG-GAP_2 PF14312.6 CDF40373.1 - 2.4 8.5 6.1 25 5.2 0.0 3.1 3 0 0 3 3 3 0 FG-GAP repeat MBOAT PF03062.19 CDF40375.1 - 2e-28 99.7 19.0 2.3e-28 99.6 19.0 1.0 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 CDF40375.1 - 6.6e-05 23.1 5.8 6.6e-05 23.1 5.8 1.6 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Flavin_Reduct PF01613.18 CDF40376.1 - 2.3e-09 37.5 3.5 1e-08 35.4 1.6 2.7 2 1 0 2 2 2 1 Flavin reductase like domain Ntox10 PF15520.6 CDF40376.1 - 0.12 12.2 0.1 0.2 11.5 0.1 1.2 1 0 0 1 1 1 0 Novel toxin 10 ANAPC4_WD40 PF12894.7 CDF40378.1 - 6.6e-12 45.6 7.8 0.23 11.8 0.1 8.2 4 2 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40378.1 - 1.8e-11 44.4 15.4 0.0062 17.4 0.1 7.6 9 0 0 9 9 9 3 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF40378.1 - 4e-08 33.1 26.1 8.6e-06 25.5 4.9 3.3 2 2 1 3 3 3 2 PQQ-like domain PD40 PF07676.12 CDF40378.1 - 7.6e-07 28.9 11.5 0.89 9.6 0.2 7.9 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 CDF40378.1 - 9.9e-05 22.3 0.2 0.0057 16.6 0.0 3.4 4 0 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 CDF40378.1 - 0.001 18.9 15.7 0.16 12.0 0.1 6.4 7 0 0 7 7 7 1 PQQ enzyme repeat TFIIIC_delta PF12657.7 CDF40378.1 - 0.035 14.0 2.2 24 4.8 0.0 4.0 4 1 0 4 4 4 0 Transcription factor IIIC subunit delta N-term PBECR2 PF18810.1 CDF40378.1 - 0.098 13.0 0.1 0.6 10.4 0.0 2.3 2 1 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 DPPIV_N PF00930.21 CDF40378.1 - 0.18 10.5 1.3 16 4.1 0.0 3.2 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Keratin_2_head PF16208.5 CDF40380.1 - 0.053 13.7 0.9 0.075 13.2 0.9 1.1 1 0 0 1 1 1 0 Keratin type II head Flavin_Reduct PF01613.18 CDF40381.1 - 5.5e-06 26.5 0.2 6.5e-06 26.3 0.2 1.4 1 1 0 1 1 1 1 Flavin reductase like domain PIF1 PF05970.14 CDF40383.1 - 2.5e-86 290.1 0.0 1.7e-71 241.3 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF40383.1 - 3.3e-51 174.2 0.0 6.3e-51 173.3 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40383.1 - 2.8e-11 43.5 0.0 5e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF40383.1 - 0.055 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain UCR_Fe-S_N PF10399.9 CDF40383.1 - 0.27 10.6 0.8 0.67 9.3 0.8 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal PIF1 PF05970.14 CDF40386.1 - 8.4e-78 262.1 0.1 2.9e-51 174.7 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF40386.1 - 8.6e-49 166.3 0.0 2.2e-48 165.0 0.0 1.7 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40386.1 - 1e-05 25.4 0.0 2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNase_PH PF01138.21 CDF40387.1 - 3.7e-12 46.9 0.0 5.2e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF40387.1 - 5.2e-05 23.2 0.1 9.9e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 zf-C4pol PF14260.6 CDF40388.1 - 0.045 14.2 0.1 0.048 14.1 0.1 1.1 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Cupin_8 PF13621.6 CDF40389.1 - 2.9e-38 132.0 0.1 3.4e-38 131.8 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CDF40389.1 - 2.5e-09 37.0 0.0 3.7e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_1 PF00190.22 CDF40389.1 - 1.1e-06 28.3 0.0 1.3e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Cupin JmjC PF02373.22 CDF40389.1 - 0.00026 21.4 0.1 0.0008 19.8 0.1 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 CDF40389.1 - 0.0016 18.1 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AAA PF00004.29 CDF40390.1 - 4e-14 53.2 0.0 1e-13 51.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDF40390.1 - 3.6e-11 43.5 0.0 1e-10 42.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF40390.1 - 2e-07 31.5 1.0 1.1e-06 29.1 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 CDF40390.1 - 0.0003 20.9 0.2 0.001 19.1 0.0 1.9 2 0 0 2 2 2 1 AAA lid domain AAA_19 PF13245.6 CDF40390.1 - 0.0015 18.9 0.0 0.0086 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDF40390.1 - 0.0068 16.3 0.0 0.091 12.7 0.0 2.3 1 1 0 1 1 1 1 NACHT domain AAA_11 PF13086.6 CDF40390.1 - 0.017 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF40390.1 - 0.022 14.5 0.3 0.12 12.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 CDF40390.1 - 0.076 13.0 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_32 PF13654.6 CDF40390.1 - 0.085 11.6 0.1 2.8 6.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDF40390.1 - 0.093 12.5 0.0 0.41 10.3 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 CDF40390.1 - 0.093 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_assoc_2 PF16193.5 CDF40390.1 - 0.11 12.9 0.1 0.29 11.5 0.1 1.7 1 0 0 1 1 1 0 AAA C-terminal domain RNA_helicase PF00910.22 CDF40390.1 - 0.13 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ANAPC4_WD40 PF12894.7 CDF40391.1 - 7.1e-10 39.1 0.0 0.15 12.4 0.0 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40391.1 - 1.2e-09 38.6 0.0 0.11 13.4 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat PD40 PF07676.12 CDF40391.1 - 0.035 14.0 0.0 2.7 8.0 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CDF40391.1 - 0.054 12.4 0.0 30 3.4 0.0 3.1 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDF40391.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Symplekin_C PF12295.8 CDF40392.1 - 6.3e-37 127.5 0.5 2e-36 125.9 0.1 2.1 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 CDF40392.1 - 5.3e-12 45.9 0.0 1.2e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) DUF3091 PF11291.8 CDF40392.1 - 0.066 13.4 0.0 5.3 7.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) Rpn3_C PF08375.11 CDF40393.1 - 2.8e-21 75.7 5.9 3.1e-21 75.6 4.1 2.1 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 CDF40393.1 - 1.9e-19 70.1 0.1 6.6e-19 68.4 0.0 2.0 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 CDF40393.1 - 0.0039 17.2 0.1 0.018 15.0 0.1 2.1 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family TPR_19 PF14559.6 CDF40393.1 - 0.016 15.7 1.7 12 6.5 0.6 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA PF00004.29 CDF40394.1 - 1.4e-52 177.6 0.0 3e-39 134.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDF40394.1 - 1.1e-09 38.9 1.0 0.0022 18.4 0.1 4.0 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CDF40394.1 - 7.6e-08 32.7 0.4 0.38 11.0 0.0 4.3 2 2 0 3 3 3 2 AAA domain PEX-1N PF09262.11 CDF40394.1 - 1.7e-06 28.4 0.0 4.2e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal Mg_chelatase PF01078.21 CDF40394.1 - 5e-06 26.0 0.0 0.0035 16.7 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CDF40394.1 - 1.6e-05 24.9 0.0 0.024 14.7 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CDF40394.1 - 2e-05 25.1 0.0 0.3 11.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 CDF40394.1 - 2.4e-05 24.1 0.0 0.00059 19.6 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 CDF40394.1 - 4.9e-05 23.1 0.0 0.00012 21.7 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain NACHT PF05729.12 CDF40394.1 - 8.7e-05 22.5 0.1 0.65 9.9 0.0 4.1 3 1 1 4 4 4 1 NACHT domain AAA_5 PF07728.14 CDF40394.1 - 9.2e-05 22.5 0.2 0.032 14.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDF40394.1 - 0.00032 20.9 0.0 0.39 10.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 CDF40394.1 - 0.00041 20.5 0.0 0.0044 17.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 CDF40394.1 - 0.00076 19.0 0.0 0.99 8.8 0.0 2.2 2 0 0 2 2 2 2 PhoH-like protein IstB_IS21 PF01695.17 CDF40394.1 - 0.0035 17.1 0.0 0.87 9.3 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CDF40394.1 - 0.0044 17.4 0.0 0.49 10.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 CDF40394.1 - 0.0077 15.8 0.4 0.43 10.1 0.0 2.6 2 1 1 3 3 3 1 AAA domain Zeta_toxin PF06414.12 CDF40394.1 - 0.0093 15.3 0.0 0.3 10.3 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin ATPase_2 PF01637.18 CDF40394.1 - 0.013 15.4 0.0 1.4 8.7 0.0 3.0 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 CDF40394.1 - 0.015 14.5 0.1 3.5 6.7 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain AFG1_ATPase PF03969.16 CDF40394.1 - 0.04 12.8 0.0 0.62 8.9 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase AAA_11 PF13086.6 CDF40394.1 - 0.051 13.4 0.0 3.8 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDF40394.1 - 0.074 12.8 0.0 0.94 9.2 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 CDF40394.1 - 0.089 13.3 0.0 13 6.3 0.0 3.2 3 0 0 3 3 3 0 ABC transporter AAA_7 PF12775.7 CDF40394.1 - 0.091 12.3 0.0 4.9 6.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 CDF40394.1 - 0.12 12.1 0.0 0.67 9.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CDF40394.1 - 0.13 12.0 0.0 1.4 8.6 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase AAA_28 PF13521.6 CDF40394.1 - 0.17 12.1 0.1 1.6 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain TIG PF01833.24 CDF40395.1 - 3.6e-19 68.6 3.0 2.3e-09 37.2 0.6 2.7 2 0 0 2 2 2 2 IPT/TIG domain GSDH PF07995.11 CDF40395.1 - 2.1e-16 60.1 0.0 3.3e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase AAA PF00004.29 CDF40396.1 - 7.1e-32 110.6 0.0 1.3e-31 109.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDF40396.1 - 0.01 15.6 0.0 0.031 14.0 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 CDF40396.1 - 0.012 15.5 0.1 0.15 12.0 0.1 2.1 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_33 PF13671.6 CDF40396.1 - 0.017 15.3 0.0 0.073 13.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_lid_3 PF17862.1 CDF40396.1 - 0.022 14.5 1.1 0.082 12.7 0.1 2.3 2 0 0 2 2 2 0 AAA+ lid domain AAA_28 PF13521.6 CDF40396.1 - 0.086 13.1 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDF40396.1 - 0.11 12.5 0.0 0.61 10.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Nucleotid_trans PF03407.16 CDF40397.1 - 1.6e-07 31.5 0.0 2.9e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase CLP1_P PF16575.5 CDF40399.1 - 1.4e-26 93.5 0.0 2.5e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 CDF40399.1 - 0.00027 21.4 1.5 0.00041 20.8 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 CDF40399.1 - 0.002 17.9 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDF40399.1 - 0.0026 18.0 0.1 0.0053 17.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CDF40399.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 CDF40399.1 - 0.015 15.9 0.1 0.039 14.5 0.1 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDF40399.1 - 0.015 15.7 0.0 0.037 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.18 CDF40399.1 - 0.023 14.0 0.0 0.054 12.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family CbiA PF01656.23 CDF40399.1 - 0.03 14.4 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 CDF40399.1 - 0.049 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDF40399.1 - 0.053 12.7 0.0 0.089 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CDF40399.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF87 PF01935.17 CDF40399.1 - 0.07 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain ABC_tran PF00005.27 CDF40399.1 - 0.1 13.1 0.6 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter G-alpha PF00503.20 CDF40399.1 - 0.15 11.2 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA PF00004.29 CDF40399.1 - 0.18 12.2 0.1 0.32 11.4 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CLP_protease PF00574.23 CDF40400.1 - 1.4e-81 272.8 1.2 1.7e-81 272.5 1.2 1.0 1 0 0 1 1 1 1 Clp protease G-patch PF01585.23 CDF40401.1 - 0.0017 18.2 0.4 0.0055 16.6 0.4 1.9 1 1 0 1 1 1 1 G-patch domain zf-U11-48K PF05253.12 CDF40401.1 - 0.055 13.4 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger O-FucT PF10250.9 CDF40402.1 - 0.00068 19.4 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Pkinase PF00069.25 CDF40405.1 - 2.3e-76 256.7 0.0 3e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40405.1 - 2.4e-44 151.6 0.0 3.5e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF40405.1 - 1e-05 25.0 0.0 7.4e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CDF40405.1 - 0.00046 19.9 0.0 0.42 10.2 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CDF40405.1 - 0.0087 16.0 3.4 0.0097 15.8 0.1 2.5 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF40405.1 - 0.018 14.4 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF40406.1 - 1.5e-25 90.5 1.5 2.6e-25 89.8 1.5 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 CDF40406.1 - 8.5e-05 21.9 0.0 0.0078 15.5 0.0 2.3 2 0 0 2 2 2 2 Fructosamine kinase Pkinase PF00069.25 CDF40406.1 - 0.0056 16.1 0.0 0.62 9.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Choline_kinase PF01633.20 CDF40406.1 - 0.013 15.0 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 CDF40406.1 - 0.015 14.9 0.3 0.059 13.0 0.1 1.9 2 0 0 2 2 2 0 RIO1 family DUF1679 PF07914.11 CDF40406.1 - 0.033 13.0 0.1 0.053 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) LCM PF04072.14 CDF40407.1 - 4.2e-20 72.5 0.0 6.1e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase CHZ PF09649.10 CDF40408.1 - 0.026 14.0 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Histone chaperone domain CHZ APH PF01636.23 CDF40409.1 - 0.00034 20.6 0.0 0.0007 19.6 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RT_RNaseH PF17917.1 CDF40411.1 - 1.3e-31 109.0 0.0 3e-31 107.8 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF40411.1 - 1.3e-28 98.9 0.0 3.5e-28 97.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF40411.1 - 2.4e-19 69.7 0.0 5.5e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF40411.1 - 1.3e-06 28.4 3.3 2.5e-06 27.5 3.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 CDF40411.1 - 0.00032 20.4 0.2 0.011 15.4 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain VEFS-Box PF09733.9 CDF40414.1 - 7.5e-20 71.1 0.7 1.3e-19 70.4 0.7 1.3 1 0 0 1 1 1 1 VEFS-Box of polycomb protein HEAT_2 PF13646.6 CDF40415.1 - 1.1e-27 96.3 13.9 1.6e-09 38.0 4.1 4.5 1 1 2 4 4 4 4 HEAT repeats HEAT PF02985.22 CDF40415.1 - 4.7e-17 60.6 12.1 0.017 15.3 0.0 6.8 7 0 0 7 7 7 5 HEAT repeat HEAT_PBS PF03130.16 CDF40415.1 - 1.1e-09 38.1 23.5 0.12 13.1 0.0 7.7 7 1 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 CDF40415.1 - 2e-08 34.6 13.6 0.42 11.2 0.1 6.5 6 0 0 6 6 6 3 HEAT-like repeat Arm PF00514.23 CDF40415.1 - 0.0033 17.4 8.5 1.1 9.4 0.1 5.8 5 1 0 5 5 5 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CDF40415.1 - 0.0038 17.3 4.6 2.6 8.1 0.0 3.8 4 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF2019 PF09450.10 CDF40415.1 - 0.0052 16.7 0.1 0.026 14.5 0.0 2.3 1 1 2 3 3 3 1 Domain of unknown function (DUF2019) ALF PF03752.13 CDF40415.1 - 0.18 11.8 3.9 0.14 12.1 0.8 2.6 2 0 0 2 2 2 0 Short repeats of unknown function Alpha-amylase PF00128.24 CDF40416.1 - 1.3e-27 97.3 0.0 1.3e-26 93.9 0.0 2.1 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Phage_integrase PF00589.22 CDF40418.1 - 4.6e-07 29.8 0.0 2.4e-05 24.2 0.0 2.4 1 1 0 1 1 1 1 Phage integrase family MOZART1 PF12554.8 CDF40418.1 - 0.17 11.7 0.2 0.42 10.4 0.2 1.6 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated DNA_ligase_A_M PF01068.21 CDF40419.1 - 1.3e-33 116.4 0.0 2e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 CDF40419.1 - 6.6e-11 42.7 0.0 1.6e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_A_N PF04675.14 CDF40419.1 - 1e-06 29.2 0.0 3.3e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 CDF40419.1 - 0.00038 20.8 0.0 0.00071 19.9 0.0 1.4 1 0 0 1 1 1 1 RNA ligase DEDD_Tnp_IS110 PF01548.17 CDF40420.1 - 7.7e-05 22.6 0.0 8.8e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Transposase Creatinase_N PF01321.18 CDF40420.1 - 0.16 12.6 0.0 0.25 12.0 0.0 1.4 1 1 1 2 2 2 0 Creatinase/Prolidase N-terminal domain ThiF PF00899.21 CDF40421.1 - 6.1e-35 120.7 0.0 1e-34 120.0 0.0 1.3 1 1 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CDF40421.1 - 0.017 15.4 1.2 0.13 12.5 1.2 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Glyco_trans_1_4 PF13692.6 CDF40421.1 - 0.042 14.3 0.0 13 6.3 0.0 2.8 3 0 0 3 3 3 0 Glycosyl transferases group 1 NAD_binding_7 PF13241.6 CDF40421.1 - 0.067 13.6 0.0 0.2 12.1 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CDF40421.1 - 0.067 13.2 0.1 0.55 10.3 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Urocanase PF01175.18 CDF40421.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain N6_N4_Mtase PF01555.18 CDF40424.1 - 3.6e-14 53.0 0.0 1.6e-12 47.6 0.0 2.2 1 1 0 1 1 1 1 DNA methylase SET PF00856.28 CDF40424.1 - 0.0069 16.8 0.0 0.042 14.2 0.0 2.2 1 1 0 1 1 1 1 SET domain N6-adenineMlase PF10237.9 CDF40424.1 - 0.015 15.1 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase MethyltransfD12 PF02086.15 CDF40424.1 - 0.16 11.6 0.1 4.5 6.9 0.0 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Helicase_C PF00271.31 CDF40425.1 - 1.2e-14 54.5 0.0 3.2e-14 53.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF40425.1 - 4.6e-10 39.5 0.0 1.6e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF40425.1 - 0.002 18.1 0.0 0.0079 16.2 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Acetyltransf_8 PF13523.6 CDF40425.1 - 0.1 12.3 0.0 0.26 10.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RNB PF00773.19 CDF40426.1 - 4.3e-27 95.3 0.1 9.8e-23 81.0 0.0 2.2 1 1 1 2 2 2 2 RNB domain Retrotran_gag_2 PF14223.6 CDF40427.1 - 7.9e-34 116.3 0.5 1.3e-33 115.6 0.5 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF40427.1 - 4.7e-22 78.4 0.1 1.5e-21 76.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF40427.1 - 5.8e-09 35.7 0.1 7.6e-08 32.1 0.0 2.6 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF40427.1 - 0.00033 20.4 0.5 0.00095 18.9 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain zf-CCHC_6 PF15288.6 CDF40427.1 - 0.067 13.0 2.4 0.19 11.6 2.4 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF40427.1 - 0.3 10.8 2.2 1.3 8.8 2.2 2.1 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF40427.1 - 0.38 10.9 3.9 0.82 9.9 3.9 1.6 1 0 0 1 1 1 0 Zinc knuckle Pkinase PF00069.25 CDF40428.1 - 2.7e-37 128.6 0.1 1.2e-36 126.5 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40428.1 - 5.8e-13 48.7 0.2 2.9e-12 46.4 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF40428.1 - 2.4e-05 23.8 0.0 6.3e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDF40428.1 - 0.00055 19.6 0.1 0.00095 18.8 0.1 1.4 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.14 CDF40428.1 - 0.00065 19.1 0.1 0.0012 18.2 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF40428.1 - 0.13 12.1 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family EPTP PF03736.17 CDF40428.1 - 0.19 11.7 0.0 0.48 10.4 0.0 1.7 1 0 0 1 1 1 0 EPTP domain rve PF00665.26 CDF40429.1 - 2.3e-21 76.2 0.1 1.5e-20 73.6 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Retrotran_gag_2 PF14223.6 CDF40429.1 - 9e-14 51.3 0.1 2.1e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type gag_pre-integrs PF13976.6 CDF40429.1 - 6.3e-08 32.4 0.1 3.8e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF40429.1 - 0.0013 18.5 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.6 CDF40429.1 - 0.06 13.1 1.5 0.19 11.5 1.5 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF40429.1 - 0.21 11.7 4.0 0.46 10.6 4.0 1.6 1 0 0 1 1 1 0 Zinc knuckle SLT PF01464.20 CDF40430.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain CAP_N PF01213.19 CDF40437.1 - 0.0027 17.3 0.8 0.0027 17.3 0.8 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 CDF40437.1 - 0.0075 16.4 0.3 0.0075 16.4 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial fission regulator Dscam_C PF12355.8 CDF40437.1 - 0.076 14.0 1.1 0.097 13.6 1.1 1.1 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Peptidase_M41 PF01434.18 CDF40438.1 - 6.6e-61 205.5 1.7 1.5e-60 204.4 1.7 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CDF40438.1 - 3.2e-42 144.1 0.0 5.8e-42 143.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF40438.1 - 1.2e-10 41.0 0.0 2.9e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDF40438.1 - 3.5e-06 27.5 0.1 0.00045 20.7 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CDF40438.1 - 4.2e-06 26.8 0.0 1.3e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDF40438.1 - 0.00014 21.7 0.0 0.00037 20.3 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF40438.1 - 0.00059 20.1 0.0 0.064 13.5 0.0 2.8 1 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CDF40438.1 - 0.0017 18.1 0.0 0.0043 16.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 CDF40438.1 - 0.0022 17.3 0.0 0.0045 16.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 CDF40438.1 - 0.013 15.6 0.0 0.05 13.7 0.0 2.0 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 CDF40438.1 - 0.015 14.7 0.2 0.031 13.7 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDF40438.1 - 0.028 14.6 0.0 0.067 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF40438.1 - 0.036 13.6 0.0 0.22 11.0 0.0 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CDF40438.1 - 0.044 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDF40438.1 - 0.047 12.8 0.0 0.21 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CDF40438.1 - 0.05 13.3 0.0 0.18 11.5 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 CDF40438.1 - 0.06 12.8 0.1 0.33 10.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 CDF40438.1 - 0.076 13.3 0.1 0.33 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CDF40438.1 - 0.08 13.5 0.1 0.27 11.8 0.1 1.8 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 CDF40438.1 - 0.085 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDF40438.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDF40438.1 - 0.15 12.0 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 CDF40438.1 - 0.16 11.3 0.1 1.3 8.3 0.0 2.4 3 0 0 3 3 3 0 KaiC Cofilin_ADF PF00241.20 CDF40440.1 - 5.9e-21 74.5 0.1 6.6e-21 74.4 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Mcl1_mid PF12341.8 CDF40441.1 - 7e-66 222.6 0.0 1.3e-64 218.4 0.0 2.1 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 CDF40441.1 - 2.1e-16 60.0 1.0 0.0061 17.4 0.1 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40441.1 - 4.9e-14 52.4 0.0 0.00012 22.3 0.0 4.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 CDF40441.1 - 0.00045 19.7 0.0 0.048 13.0 0.0 2.3 2 0 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal SUZ-C PF12901.7 CDF40441.1 - 0.16 12.0 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 SUZ-C motif Rhomboid PF01694.22 CDF40445.1 - 5.7e-34 117.3 9.8 5.7e-34 117.3 9.8 2.0 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 CDF40445.1 - 0.11 13.1 0.6 0.3 11.7 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) ABC_tran PF00005.27 CDF40446.1 - 9.7e-12 45.6 0.0 1.1e-11 45.4 0.0 1.0 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDF40446.1 - 0.00019 21.3 0.0 0.00019 21.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDF40446.1 - 0.00039 20.8 0.0 0.0004 20.8 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CDF40446.1 - 0.0014 18.7 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF40446.1 - 0.0017 18.3 0.1 0.0021 18.0 0.1 1.3 1 1 0 1 1 1 1 RsgA GTPase Zeta_toxin PF06414.12 CDF40446.1 - 0.0024 17.2 0.0 0.0025 17.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 CDF40446.1 - 0.0028 17.8 0.0 0.0028 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF40446.1 - 0.004 16.8 0.2 0.011 15.5 0.1 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDF40446.1 - 0.0064 16.8 0.0 0.0064 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDF40446.1 - 0.0077 16.0 0.0 0.0077 16.0 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 CDF40446.1 - 0.0079 15.9 0.0 0.0079 15.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDF40446.1 - 0.0095 16.2 0.0 0.0095 16.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CDF40446.1 - 0.017 15.0 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 CDF40446.1 - 0.04 14.5 0.0 0.04 14.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDF40446.1 - 0.049 14.1 0.2 0.055 14.0 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF40446.1 - 0.073 12.8 0.0 0.077 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDF40446.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_10 PF12846.7 CDF40446.1 - 0.16 10.8 0.0 0.16 10.8 0.0 1.0 1 0 0 1 1 1 0 AAA-like domain Viral_helicase1 PF01443.18 CDF40446.1 - 0.17 11.6 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF87 PF01935.17 CDF40446.1 - 0.21 11.6 0.1 0.27 11.3 0.1 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain Coatomer_WDAD PF04053.14 CDF40448.1 - 1.2e-112 377.2 0.0 2e-112 376.5 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 CDF40448.1 - 2.4e-92 309.8 0.0 3.4e-92 309.3 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CDF40448.1 - 1.1e-40 136.8 18.6 2.5e-08 34.4 0.4 7.9 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40448.1 - 2.3e-09 37.4 1.2 0.0019 18.4 0.0 5.6 4 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF40448.1 - 0.0015 17.3 8.7 0.41 9.2 0.1 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Glyco_transf_22 PF03901.17 CDF40450.1 - 5.8e-36 124.6 26.3 8e-36 124.2 26.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family RRM_1 PF00076.22 CDF40451.1 - 2.8e-28 97.5 0.1 1.9e-15 56.5 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDF40451.1 - 1.7e-06 28.0 0.0 0.00041 20.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif TcpA PF05946.12 CDF40451.1 - 0.0014 18.7 0.0 0.0032 17.6 0.0 1.5 1 1 0 1 1 1 1 Toxin-coregulated pilus subunit TcpA Spo7_2_N PF15407.6 CDF40451.1 - 0.0058 16.2 0.0 0.3 10.8 0.0 2.3 2 0 0 2 2 2 1 Sporulation protein family 7 AAA_lid_6 PF17866.1 CDF40453.1 - 9.8e-13 48.1 0.1 9.8e-13 48.1 0.1 2.2 2 0 0 2 2 2 1 AAA lid domain AAA PF00004.29 CDF40453.1 - 2.4e-12 47.4 0.0 4.4e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDF40453.1 - 0.00047 20.2 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDF40453.1 - 0.0011 18.3 0.5 0.011 15.2 0.3 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDF40453.1 - 0.0018 18.6 0.2 0.25 11.6 0.2 2.6 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CDF40453.1 - 0.0027 17.7 0.2 0.0052 16.7 0.2 1.5 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.6 CDF40453.1 - 0.0088 16.4 0.2 0.045 14.1 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Nsp1_C PF05064.13 CDF40453.1 - 0.0095 15.7 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 1 Nsp1-like C-terminal region AAA_19 PF13245.6 CDF40453.1 - 0.019 15.3 0.3 0.068 13.5 0.2 1.9 1 1 1 2 2 1 0 AAA domain AAA_18 PF13238.6 CDF40453.1 - 0.034 14.7 4.2 0.096 13.2 0.3 2.8 3 1 0 3 3 3 0 AAA domain APS_kinase PF01583.20 CDF40453.1 - 0.036 14.0 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase ResIII PF04851.15 CDF40453.1 - 0.042 13.9 0.0 0.098 12.7 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Torsin PF06309.11 CDF40453.1 - 0.045 13.8 0.0 0.11 12.7 0.0 1.7 1 1 0 1 1 1 0 Torsin AAA_33 PF13671.6 CDF40453.1 - 0.049 13.8 0.0 0.049 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDF40453.1 - 0.058 13.8 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 RNA helicase MeaB PF03308.16 CDF40453.1 - 0.062 12.3 0.3 0.16 10.9 0.3 1.7 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 CDF40453.1 - 0.063 12.5 1.3 1.8 7.7 1.3 2.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CDF40453.1 - 0.087 12.5 0.1 0.23 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 CDF40453.1 - 0.089 12.9 1.3 0.36 10.9 0.1 2.2 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_28 PF13521.6 CDF40453.1 - 0.14 12.4 0.2 0.14 12.4 0.2 2.0 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF40453.1 - 0.15 11.3 0.0 0.35 10.0 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain Zot PF05707.12 CDF40453.1 - 0.16 11.6 0.1 6.8 6.3 0.1 2.3 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) KTI12 PF08433.10 CDF40453.1 - 0.25 10.7 0.0 0.25 10.7 0.0 1.5 2 0 0 2 2 1 0 Chromatin associated protein KTI12 AAA_11 PF13086.6 CDF40453.1 - 0.31 10.8 1.7 1.3 8.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDF40453.1 - 0.39 10.3 4.0 1.7 8.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain DNA_pol_B PF00136.21 CDF40454.1 - 2.3e-134 448.6 0.0 2.9e-134 448.2 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDF40454.1 - 2.4e-75 253.8 0.0 3.5e-75 253.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CDF40454.1 - 4.6e-15 55.8 6.7 9.7e-15 54.8 6.7 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 CDF40454.1 - 0.022 13.7 0.0 0.046 12.6 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral DNA_pol_A_exo1 PF01612.20 CDF40454.1 - 0.029 14.1 0.0 0.095 12.4 0.0 1.8 2 0 0 2 2 2 0 3'-5' exonuclease RNase_H_2 PF13482.6 CDF40454.1 - 0.046 13.7 0.0 0.29 11.1 0.0 2.4 1 1 0 1 1 1 0 RNase_H superfamily CAP_N PF01213.19 CDF40455.1 - 5.4 6.4 5.8 3.2 7.2 3.7 1.6 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Pkinase PF00069.25 CDF40456.1 - 4.3e-05 23.0 0.0 8.6e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain N6_N4_Mtase PF01555.18 CDF40457.1 - 2.9e-14 53.3 0.0 4.1e-13 49.6 0.0 2.2 1 1 0 1 1 1 1 DNA methylase SET PF00856.28 CDF40457.1 - 0.007 16.8 0.0 0.036 14.4 0.0 2.2 1 1 0 1 1 1 1 SET domain N6-adenineMlase PF10237.9 CDF40457.1 - 0.013 15.3 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase MethyltransfD12 PF02086.15 CDF40457.1 - 0.16 11.7 0.1 4.5 6.9 0.0 2.2 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase UPF0020 PF01170.18 CDF40457.1 - 0.19 11.4 0.0 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 DEAD PF00270.29 CDF40458.1 - 9e-10 38.6 0.0 2.7e-09 37.1 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF40458.1 - 0.004 17.2 0.0 0.013 15.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit NAD_Gly3P_dh_C PF07479.14 CDF40458.1 - 0.014 15.6 0.1 2.4 8.4 0.1 2.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus CyRPA PF18638.1 CDF40458.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain Arg_decarbox_C PF17944.1 CDF40458.1 - 0.14 12.7 0.1 0.66 10.6 0.1 2.2 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension Acetyltransf_8 PF13523.6 CDF40458.1 - 0.16 11.7 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain YjeF_N PF03853.15 CDF40459.1 - 7.8e-22 78.0 0.0 1.3e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF2781 PF10914.8 CDF40460.1 - 0.034 14.6 0.6 0.034 14.6 0.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) Sel1 PF08238.12 CDF40462.1 - 1.2e-20 73.4 27.4 5.2e-06 27.0 0.3 7.8 7 0 0 7 7 7 5 Sel1 repeat TPR_7 PF13176.6 CDF40462.1 - 0.019 15.0 7.7 0.76 10.0 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40462.1 - 0.046 14.2 7.2 0.085 13.4 1.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40462.1 - 1.2 9.5 7.6 7.5 7.0 0.0 4.9 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40462.1 - 3.1 7.8 8.5 7.4 6.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Alg6_Alg8 PF03155.15 CDF40463.1 - 1.2e-119 400.5 22.0 1.4e-119 400.2 22.0 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Ribosomal_L28 PF00830.19 CDF40465.1 - 1.7e-18 66.5 0.9 3.1e-18 65.7 0.9 1.4 1 0 0 1 1 1 1 Ribosomal L28 family Aconitase PF00330.20 CDF40466.1 - 2.2e-150 501.7 0.0 2.8e-150 501.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDF40466.1 - 6.7e-45 152.6 0.0 1.2e-44 151.8 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF4460 PF14687.6 CDF40467.1 - 5.3e-11 42.5 0.7 1.1e-10 41.5 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF4461 PF14688.6 CDF40467.1 - 8.5e-10 38.9 0.3 1.8e-09 37.8 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4461) DnaJ PF00226.31 CDF40467.1 - 0.15 12.2 0.3 0.45 10.7 0.3 1.8 1 0 0 1 1 1 0 DnaJ domain Tfb2 PF03849.14 CDF40468.1 - 6.1e-82 275.4 0.0 7.8e-82 275.1 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 CDF40468.1 - 1.4e-20 73.5 0.0 3e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 CDF40468.1 - 0.0043 17.2 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA PF00004.29 CDF40469.1 - 8.1e-95 314.3 0.0 6.6e-47 159.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDF40469.1 - 1.2e-24 85.8 12.8 5.1e-14 51.8 0.5 3.2 3 1 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 CDF40469.1 - 3.4e-21 75.2 0.3 8.7e-21 73.9 0.3 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 CDF40469.1 - 5.2e-14 52.3 0.0 1.5e-05 24.8 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF40469.1 - 1e-12 48.8 0.3 0.00038 20.9 0.0 4.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 CDF40469.1 - 3.2e-12 46.9 0.0 6.4e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDF40469.1 - 8.9e-12 45.4 0.0 1.4e-05 25.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 CDF40469.1 - 2e-11 43.5 0.0 4e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.14 CDF40469.1 - 5.4e-11 42.7 0.1 1e-05 25.6 0.0 3.4 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDF40469.1 - 1e-08 34.8 0.0 0.0013 18.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 CDF40469.1 - 1.4e-08 35.1 0.2 0.068 13.4 0.0 3.9 2 2 1 3 3 2 2 AAA domain Mg_chelatase PF01078.21 CDF40469.1 - 2.7e-07 30.2 0.3 0.028 13.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CDF40469.1 - 6.4e-07 29.5 0.0 0.02 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDF40469.1 - 8.4e-07 29.6 0.0 0.031 14.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDF40469.1 - 3.5e-06 27.4 0.0 0.038 14.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase ATPase_2 PF01637.18 CDF40469.1 - 6.7e-06 26.2 0.1 0.55 10.1 0.1 3.5 3 1 0 3 3 2 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDF40469.1 - 6.7e-06 25.9 0.0 0.061 13.0 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_17 PF13207.6 CDF40469.1 - 9.8e-06 26.0 0.0 0.17 12.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 CDF40469.1 - 1.7e-05 24.7 0.2 0.00023 21.1 0.1 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_25 PF13481.6 CDF40469.1 - 2.2e-05 24.2 2.6 0.92 9.0 0.0 4.5 3 2 1 5 5 5 1 AAA domain Bac_DnaA PF00308.18 CDF40469.1 - 2.3e-05 24.4 0.0 0.063 13.1 0.0 2.6 2 0 0 2 2 2 2 Bacterial dnaA protein Viral_helicase1 PF01443.18 CDF40469.1 - 2.5e-05 24.2 0.0 0.0086 15.8 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 CDF40469.1 - 2.6e-05 24.0 0.0 0.23 11.2 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 CDF40469.1 - 5e-05 22.9 0.0 0.14 11.6 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 CDF40469.1 - 5.4e-05 23.2 0.1 0.34 10.8 0.0 3.5 3 1 1 4 4 3 1 NACHT domain Parvo_NS1 PF01057.17 CDF40469.1 - 6.4e-05 22.2 0.0 0.069 12.2 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 CDF40469.1 - 6.9e-05 22.7 0.1 0.35 10.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 CDF40469.1 - 7.1e-05 23.3 0.0 0.099 13.2 0.0 2.7 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 CDF40469.1 - 7.8e-05 22.0 0.0 0.41 9.9 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin TsaE PF02367.17 CDF40469.1 - 8.4e-05 22.6 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 CDF40469.1 - 0.00012 21.5 1.3 3.4 6.9 0.0 3.6 4 0 0 4 4 3 0 KaiC AAA_28 PF13521.6 CDF40469.1 - 0.00013 22.2 0.2 0.45 10.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain DUF2075 PF09848.9 CDF40469.1 - 0.00018 20.9 0.0 0.48 9.6 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 CDF40469.1 - 0.00039 20.5 0.0 0.44 10.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 CDF40469.1 - 0.0005 19.3 0.0 0.47 9.6 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ResIII PF04851.15 CDF40469.1 - 0.00098 19.2 0.0 0.32 11.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 CDF40469.1 - 0.0016 18.0 0.2 1.8 7.9 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.11 CDF40469.1 - 0.0028 17.5 0.0 3.3 7.6 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDF40469.1 - 0.0031 16.7 0.0 0.46 9.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 CDF40469.1 - 0.0033 17.4 0.7 2.3 8.1 0.0 4.1 3 1 0 4 4 4 1 NTPase Zot PF05707.12 CDF40469.1 - 0.0045 16.7 0.0 0.43 10.2 0.0 2.8 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) UFD1 PF03152.14 CDF40469.1 - 0.0048 16.4 0.0 0.0089 15.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AAA_19 PF13245.6 CDF40469.1 - 0.0053 17.1 0.3 6.5 7.1 0.0 3.4 3 1 0 4 4 2 0 AAA domain Cytidylate_kin2 PF13189.6 CDF40469.1 - 0.0066 16.6 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_30 PF13604.6 CDF40469.1 - 0.0076 16.0 0.0 2.8 7.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 CDF40469.1 - 0.0094 15.7 0.0 4.4 7.0 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase AAA_11 PF13086.6 CDF40469.1 - 0.012 15.5 0.3 7.1 6.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 CDF40469.1 - 0.015 15.0 0.0 4.5 7.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain SKI PF01202.22 CDF40469.1 - 0.017 15.2 0.5 17 5.5 0.0 3.3 3 0 0 3 3 3 0 Shikimate kinase KAP_NTPase PF07693.14 CDF40469.1 - 0.02 14.2 0.2 0.74 9.0 0.0 2.8 2 2 2 4 4 4 0 KAP family P-loop domain T2SSE PF00437.20 CDF40469.1 - 0.033 13.3 0.0 2.4 7.2 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein KTI12 PF08433.10 CDF40469.1 - 0.077 12.4 0.1 6.3 6.1 0.0 2.5 2 1 0 2 2 2 0 Chromatin associated protein KTI12 DEAD PF00270.29 CDF40469.1 - 0.082 12.7 0.2 27 4.5 0.0 3.4 2 2 0 3 3 3 0 DEAD/DEAH box helicase AAA_23 PF13476.6 CDF40469.1 - 0.16 12.4 0.5 17 5.8 0.0 2.8 3 0 0 3 3 2 0 AAA domain Hydin_ADK PF17213.3 CDF40469.1 - 0.22 11.8 2.4 40 4.4 0.0 3.7 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain AFG1_ATPase PF03969.16 CDF40469.1 - 2.5 6.9 5.8 9 5.1 0.0 3.1 4 0 0 4 4 4 0 AFG1-like ATPase Nas2_N PF18265.1 CDF40471.1 - 3e-23 81.5 0.0 5e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 CDF40471.1 - 4.1e-06 26.5 0.1 1.9e-05 24.4 0.1 2.0 1 1 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 CDF40471.1 - 8e-05 23.0 0.0 0.00013 22.3 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 CDF40471.1 - 0.003 17.9 0.1 0.0068 16.7 0.1 1.7 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDF40471.1 - 0.043 14.2 0.0 0.094 13.1 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Ribosomal_L12 PF00542.19 CDF40472.1 - 6.9e-24 84.0 9.9 6.9e-24 84.0 9.9 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CDF40472.1 - 9.5e-10 38.0 0.3 9.5e-10 38.0 0.3 2.6 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain WD40 PF00400.32 CDF40473.1 - 3.7e-34 116.2 18.8 5e-06 27.2 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 CDF40473.1 - 1.4e-07 30.6 1.5 0.05 12.3 0.1 4.3 4 1 1 5 5 5 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CDF40473.1 - 0.0016 18.7 0.0 9.8 6.6 0.0 3.9 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1664 PF07889.12 CDF40473.1 - 0.0096 16.0 0.5 0.016 15.2 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) WD40_like PF17005.5 CDF40473.1 - 0.051 12.9 0.0 0.28 10.5 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain Spc24 PF08286.11 CDF40473.1 - 0.086 13.1 1.2 0.19 12.0 1.2 1.6 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 EzrA PF06160.12 CDF40473.1 - 0.1 10.8 1.3 0.14 10.3 1.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA MadL PF03817.13 CDF40473.1 - 0.18 11.8 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 Malonate transporter MadL subunit TACC_C PF05010.14 CDF40473.1 - 0.25 11.1 2.2 0.38 10.5 2.2 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DivIC PF04977.15 CDF40473.1 - 4 7.3 8.5 1.6 8.6 0.1 2.7 2 1 1 3 3 3 0 Septum formation initiator Pkinase PF00069.25 CDF40474.1 - 1.7e-52 178.4 0.1 2.7e-52 177.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40474.1 - 4.2e-34 118.0 0.0 6.4e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 CDF40474.1 - 6.1e-34 116.5 0.0 6e-10 39.6 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 CDF40474.1 - 1.4e-22 79.0 1.4 9.7e-05 22.6 0.2 6.6 5 1 1 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 CDF40474.1 - 1.8e-22 79.1 0.5 8.2e-07 29.2 0.1 4.1 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDF40474.1 - 5.7e-21 74.6 0.1 2.7e-06 27.8 0.0 5.0 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDF40474.1 - 3.9e-16 57.5 1.9 0.0091 16.4 0.0 6.7 7 0 0 7 7 7 3 Ankyrin repeat OSR1_C PF12202.8 CDF40474.1 - 0.013 15.7 0.8 0.13 12.5 0.2 2.5 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain ER_lumen_recept PF00810.18 CDF40477.1 - 1.3e-56 191.5 13.0 1.9e-56 191.0 13.0 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 CDF40477.1 - 9.3e-05 22.1 6.6 0.065 13.0 0.3 3.9 3 1 1 4 4 4 2 PQ loop repeat Kelch_1 PF01344.25 CDF40477.1 - 0.13 11.9 2.3 0.14 11.7 0.4 1.9 2 0 0 2 2 2 0 Kelch motif GATase_5 PF13507.6 CDF40480.1 - 1.1e-102 342.6 0.0 1.8e-102 341.9 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CDF40480.1 - 1.3e-32 113.1 1.2 2.1e-19 70.2 0.1 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CDF40480.1 - 1.3e-17 63.8 0.0 2.6e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CDF40480.1 - 7.6e-13 48.8 0.0 1.8e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 CDF40480.1 - 0.017 15.8 0.1 0.096 13.3 0.0 2.4 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain Glycolytic PF00274.19 CDF40481.1 - 3.5e-156 519.3 0.0 3.9e-156 519.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I HAD PF12710.7 CDF40482.1 - 1.3e-18 68.1 0.1 2.7e-18 67.1 0.1 1.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDF40482.1 - 5.2e-14 53.0 0.0 6.4e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF40482.1 - 5.3e-10 39.5 0.0 2.2e-09 37.4 0.0 1.7 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDF40482.1 - 9e-05 22.6 0.0 0.00042 20.4 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDF40482.1 - 0.0046 16.5 0.0 0.0062 16.1 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Put_Phosphatase PF06888.12 CDF40482.1 - 0.0076 15.7 0.0 0.71 9.2 0.0 2.0 2 0 0 2 2 2 2 Putative Phosphatase Hydrolase_like PF13242.6 CDF40482.1 - 0.13 12.4 0.1 3 8.0 0.0 2.4 2 1 0 2 2 2 0 HAD-hyrolase-like p450 PF00067.22 CDF40484.1 - 1.2e-58 199.0 0.0 1.5e-58 198.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2 PF00096.26 CDF40485.1 - 6.1e-08 32.7 10.2 6.1e-05 23.2 2.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF40485.1 - 0.00024 21.7 8.4 0.028 15.3 1.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDF40485.1 - 0.0026 18.1 1.4 0.0026 18.1 1.4 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 CDF40485.1 - 0.021 15.1 0.6 0.021 15.1 0.6 1.7 2 0 0 2 2 2 0 C2H2-type zinc ribbon PAC4 PF16093.5 CDF40485.1 - 0.056 13.6 0.8 0.12 12.6 0.8 1.7 1 1 0 1 1 1 0 Proteasome assembly chaperone 4 zf-C2H2_jaz PF12171.8 CDF40485.1 - 0.067 13.5 0.6 0.62 10.4 0.1 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF2256 PF10013.9 CDF40485.1 - 0.23 11.6 0.4 0.23 11.6 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) ABC_membrane PF00664.23 CDF40488.1 - 2.9e-38 132.1 3.9 3.8e-38 131.7 3.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDF40488.1 - 2.3e-35 122.1 0.0 3.6e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDF40488.1 - 3.6e-05 23.3 0.5 0.0011 18.5 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDF40488.1 - 0.00037 20.8 0.1 0.002 18.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDF40488.1 - 0.00087 18.6 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDF40488.1 - 0.0051 17.2 1.0 0.016 15.6 0.9 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDF40488.1 - 0.016 14.9 0.0 0.04 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 CDF40488.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_ATPase PF09818.9 CDF40488.1 - 0.02 13.7 0.1 0.036 12.9 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CDF40488.1 - 0.029 14.3 0.0 0.067 13.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 CDF40488.1 - 0.03 14.5 0.7 0.3 11.3 0.7 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 CDF40488.1 - 0.032 13.9 0.0 0.043 13.5 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CDF40488.1 - 0.041 13.9 0.0 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CDF40488.1 - 0.049 12.8 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_28 PF13521.6 CDF40488.1 - 0.051 13.8 0.3 0.16 12.2 0.3 1.9 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDF40488.1 - 0.067 12.9 3.1 0.68 9.6 3.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDF40488.1 - 0.078 12.8 0.1 2.7 7.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Pkinase_Tyr PF07714.17 CDF40489.1 - 6.4e-61 205.9 0.0 8.7e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF40489.1 - 3e-52 177.6 0.0 4.7e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TIR_2 PF13676.6 CDF40489.1 - 4.6e-10 40.1 0.0 1.2e-09 38.8 0.0 1.7 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 CDF40489.1 - 0.0087 15.9 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain CLTH PF10607.9 CDF40490.1 - 3.2e-07 30.3 0.7 6.3e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 CTLH/CRA C-terminal to LisH motif domain GATase_6 PF13522.6 CDF40490.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain TIP49 PF06068.13 CDF40491.1 - 1.5e-166 553.9 0.5 1.9e-166 553.6 0.5 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDF40491.1 - 2.2e-18 66.1 0.2 9.9e-18 64.0 0.0 2.3 3 0 0 3 3 2 1 TIP49 AAA-lid domain AAA PF00004.29 CDF40491.1 - 2.8e-08 34.2 0.3 6.6e-05 23.3 0.1 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDF40491.1 - 1.1e-06 28.5 0.6 0.0016 18.2 0.1 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF40491.1 - 5.2e-06 26.8 0.3 0.026 14.8 0.0 2.4 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDF40491.1 - 0.00045 20.7 0.4 0.0055 17.1 0.1 2.4 2 1 0 2 2 1 1 AAA ATPase domain AAA_28 PF13521.6 CDF40491.1 - 0.0011 19.2 0.0 0.0029 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CDF40491.1 - 0.0027 17.4 0.2 1.5 8.5 0.1 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 CDF40491.1 - 0.0029 17.6 0.1 0.0059 16.6 0.1 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TFIID-31kDa PF02291.15 CDF40491.1 - 0.012 15.7 0.1 0.23 11.6 0.2 2.6 3 0 0 3 3 3 0 Transcription initiation factor IID, 31kD subunit T2SSE PF00437.20 CDF40491.1 - 0.023 13.7 0.1 0.089 11.8 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF2075 PF09848.9 CDF40491.1 - 0.029 13.6 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CDF40491.1 - 0.036 14.0 0.1 0.071 13.0 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 CDF40491.1 - 0.051 13.6 0.0 5.1 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain CoaE PF01121.20 CDF40491.1 - 0.075 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_18 PF13238.6 CDF40491.1 - 0.086 13.4 0.0 0.25 11.9 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_5 PF07728.14 CDF40491.1 - 0.11 12.5 0.1 6.1 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 CDF40491.1 - 0.11 12.4 0.2 0.45 10.4 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDF40491.1 - 0.13 12.0 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.6 CDF40491.1 - 0.14 11.9 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 CDF40491.1 - 0.15 12.4 2.0 1.3 9.3 2.0 2.3 1 1 0 1 1 1 0 AAA domain DBI_PRT PF02277.17 CDF40491.1 - 0.28 10.4 5.7 0.026 13.8 1.1 1.6 2 0 0 2 2 2 0 Phosphoribosyltransferase RNA_pol_L_2 PF13656.6 CDF40492.1 - 1.3e-29 101.8 0.0 1.7e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CDF40492.1 - 3.5e-11 42.4 0.0 5.8e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF3834 PF12916.7 CDF40492.1 - 0.054 12.7 0.0 0.062 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) Fcf1 PF04900.12 CDF40493.1 - 1.5e-17 63.8 0.2 4.9e-17 62.2 0.0 1.9 2 0 0 2 2 2 1 Fcf1 Glu-tRNAGln PF02686.15 CDF40494.1 - 1.4e-14 54.1 0.7 2.3e-14 53.4 0.7 1.4 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit YgaB PF14182.6 CDF40494.1 - 0.17 12.3 0.0 0.3 11.5 0.0 1.3 1 0 0 1 1 1 0 YgaB-like protein zf-C2HC5 PF06221.13 CDF40495.1 - 0.01 15.8 1.0 0.019 15.0 1.0 1.3 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Sel1 PF08238.12 CDF40498.1 - 0.023 15.4 0.0 0.032 14.9 0.0 1.3 1 0 0 1 1 1 0 Sel1 repeat Fer4 PF00037.27 CDF40500.1 - 8 6.5 16.5 7.3 6.6 3.3 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Flavin_Reduct PF01613.18 CDF40505.1 - 7.1e-10 39.1 2.5 5.4e-09 36.3 2.5 2.1 1 1 0 1 1 1 1 Flavin reductase like domain SPX PF03105.19 CDF40508.1 - 8e-22 78.7 8.4 5.2e-12 46.4 0.1 2.7 1 1 0 2 2 2 2 SPX domain CitMHS PF03600.16 CDF40508.1 - 1e-14 54.5 10.4 1.6e-14 53.8 10.4 1.3 1 0 0 1 1 1 1 Citrate transporter Na_sulph_symp PF00939.19 CDF40508.1 - 5.9e-13 48.7 9.5 8.5e-13 48.2 9.5 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region LPD3 PF18798.1 CDF40508.1 - 0.061 13.6 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 3 FA_desaturase PF00487.24 CDF40508.1 - 0.096 12.5 0.1 0.096 12.5 0.1 4.1 3 2 1 4 4 4 0 Fatty acid desaturase GYF PF02213.16 CDF40511.1 - 7.8e-14 51.1 0.4 1.5e-13 50.1 0.4 1.5 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CDF40511.1 - 0.0029 17.4 0.1 0.0084 15.9 0.1 1.8 1 0 0 1 1 1 1 GYF domain 2 LegC3_N PF18654.1 CDF40512.1 - 0.038 13.2 13.3 0.059 12.6 13.3 1.2 1 0 0 1 1 1 0 LegC3 N-terminal coiled-coil domain DUF2157 PF09925.9 CDF40512.1 - 0.13 12.0 3.8 0.25 11.1 2.9 2.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Rota_NSP4 PF01452.16 CDF40512.1 - 1 9.0 5.5 0.85 9.3 2.4 2.2 2 0 0 2 2 2 0 Rotavirus non structural protein Fez1 PF06818.15 CDF40512.1 - 5.1 7.5 16.6 9.2 6.7 16.6 1.4 1 0 0 1 1 1 0 Fez1 RsfS PF02410.15 CDF40514.1 - 3.6e-09 36.9 0.0 1e-08 35.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal silencing factor during starvation SPT6_acidic PF14632.6 CDF40514.1 - 0.045 14.3 1.8 0.087 13.4 1.8 1.5 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DNase_NucA_NucB PF14040.6 CDF40514.1 - 0.079 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB MutS_V PF00488.21 CDF40516.1 - 1.9e-45 155.2 0.1 4e-42 144.4 0.1 2.4 1 1 0 1 1 1 1 MutS domain V MutS_IV PF05190.18 CDF40516.1 - 3.2e-07 30.6 0.1 7.2e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 CDF40516.1 - 0.0039 16.8 0.0 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF40516.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Acylphosphatase PF00708.18 CDF40518.1 - 3.6e-17 62.5 0.0 4.2e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Acylphosphatase DUF563 PF04577.14 CDF40519.1 - 2.4e-13 50.7 0.0 5.9e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF4131 PF13567.6 CDF40519.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PIF1 PF05970.14 CDF40520.1 - 3.2e-77 260.2 0.0 1.2e-58 199.0 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF40520.1 - 1.2e-53 182.2 0.0 2.4e-53 181.2 0.0 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40520.1 - 4.9e-10 39.4 0.0 8.6e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Glycos_transf_4 PF00953.21 CDF40522.1 - 3.5e-36 124.6 13.0 3.5e-36 124.6 13.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 4 EMP70 PF02990.16 CDF40524.1 - 1.1e-179 598.4 0.9 1.1e-179 598.4 0.9 1.3 1 1 0 1 1 1 1 Endomembrane protein 70 Arf PF00025.21 CDF40525.1 - 1.2e-41 142.1 0.0 6.6e-41 139.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDF40525.1 - 5.6e-10 39.5 0.0 1.3e-09 38.3 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDF40525.1 - 1.9e-08 33.9 0.0 0.00028 20.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CDF40525.1 - 1.5e-05 25.1 0.0 2.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 CDF40525.1 - 2e-05 24.2 0.0 8.1e-05 22.3 0.0 1.8 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 CDF40525.1 - 4.9e-05 22.8 0.0 6.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDF40525.1 - 0.00035 20.0 0.0 0.00071 19.0 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region NACHT PF05729.12 CDF40525.1 - 0.021 14.7 0.2 0.1 12.5 0.2 1.9 1 1 0 1 1 1 0 NACHT domain Dynamin_N PF00350.23 CDF40525.1 - 0.032 14.3 0.2 0.63 10.1 0.2 2.1 2 0 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 CDF40525.1 - 0.16 11.7 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain RNase_HII PF01351.18 CDF40526.1 - 4e-36 124.7 0.0 4.9e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII ORC2 PF04084.14 CDF40528.1 - 1.2e-71 241.4 0.1 1.3e-71 241.2 0.1 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Mpv17_PMP22 PF04117.12 CDF40529.1 - 2.4e-22 78.9 2.1 4.1e-22 78.2 2.1 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family zf-CCCH PF00642.24 CDF40532.1 - 4.1e-13 48.9 38.2 0.0038 17.1 1.5 5.2 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDF40532.1 - 1.2e-10 41.1 51.6 0.0097 15.9 4.6 6.0 5 1 0 5 5 5 4 Zinc finger domain Torus PF16131.5 CDF40532.1 - 3.9e-08 34.0 28.6 0.019 15.6 0.7 5.1 1 1 4 5 5 5 5 Torus domain zf-CCCH_3 PF15663.5 CDF40532.1 - 3e-06 27.4 18.6 0.0004 20.6 4.1 3.5 1 1 2 3 3 3 3 Zinc-finger containing family zf-CCCH_4 PF18044.1 CDF40532.1 - 0.00018 21.2 2.8 0.00018 21.2 2.8 5.0 5 1 0 5 5 5 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDF40532.1 - 0.064 13.8 39.9 0.56 10.8 3.3 6.2 6 1 0 6 6 6 0 RNA-binding, Nab2-type zinc finger DUF647 PF04884.14 CDF40533.1 - 5.5e-66 222.6 1.2 6.9e-66 222.3 1.2 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis VPS13_C PF16909.5 CDF40534.1 - 1.1e-38 132.8 0.5 9.6e-35 120.0 0.0 2.6 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 CDF40534.1 - 3e-16 59.6 0.0 7.6e-16 58.3 0.0 1.8 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 CDF40534.1 - 0.0041 17.4 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain ChuX_HutX PF06228.13 CDF40534.1 - 0.096 12.5 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Haem utilisation ChuX/HutX VPS13 PF16908.5 CDF40535.1 - 2.1e-31 109.5 0.1 7e-31 107.8 0.0 1.8 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 CDF40535.1 - 3.2e-27 94.9 0.0 7e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_mid_rpt PF16910.5 CDF40535.1 - 2.4e-05 23.9 0.0 0.0017 17.9 0.0 2.3 2 0 0 2 2 2 2 Repeating coiled region of VPS13 V_ATPase_I PF01496.19 CDF40536.1 - 7e-279 927.2 0.0 1.2e-277 923.2 0.0 2.0 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family DASH_Hsk3 PF08227.11 CDF40536.1 - 0.45 10.9 3.1 9.8 6.6 0.2 2.8 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like TPR_2 PF07719.17 CDF40537.1 - 1.1e-36 122.0 3.2 0.0021 18.0 0.0 12.9 13 0 0 13 13 13 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40537.1 - 1.3e-33 112.8 25.6 2e-06 28.2 0.6 11.5 2 2 10 12 12 12 8 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40537.1 - 2.1e-29 99.8 0.0 0.052 14.0 0.0 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40537.1 - 7.2e-27 93.7 0.0 1.5e-06 28.6 0.0 6.6 4 3 1 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40537.1 - 1.6e-21 74.7 0.0 0.05 13.8 0.0 11.0 12 1 1 13 13 12 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDF40537.1 - 4.2e-20 71.2 0.0 0.00026 20.6 0.0 8.1 8 2 2 10 10 8 5 TPR repeat TPR_16 PF13432.6 CDF40537.1 - 3.9e-18 65.8 11.2 0.0031 18.1 0.1 8.2 6 2 3 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDF40537.1 - 4e-16 59.1 13.5 0.00052 20.3 0.0 8.2 5 3 2 7 7 7 5 Tetratricopeptide repeat TPR_9 PF13371.6 CDF40537.1 - 3.1e-15 56.1 13.1 0.003 17.7 0.0 6.7 4 2 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40537.1 - 6.3e-15 54.3 0.0 0.2 11.5 0.0 10.0 11 1 1 12 12 12 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF40537.1 - 7.2e-11 42.2 1.4 3.2 7.8 0.0 7.5 6 4 3 9 9 9 2 Mad3/BUB1 homology region 1 TPR_6 PF13174.6 CDF40537.1 - 1.8e-10 40.7 17.8 0.22 12.2 0.0 10.0 10 1 0 10 10 10 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDF40537.1 - 2.8e-10 39.9 14.0 0.00052 19.3 0.8 5.0 1 1 1 4 4 4 4 Tetratricopeptide repeat Suf PF05843.14 CDF40537.1 - 1.5e-08 35.0 0.0 0.064 13.2 0.0 4.5 3 3 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_7 PF13176.6 CDF40537.1 - 6e-06 25.9 5.6 8.9 6.6 0.0 7.9 8 1 0 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF40537.1 - 1e-05 25.6 0.0 0.034 14.4 0.0 4.7 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 CDF40537.1 - 0.0048 16.9 5.5 9.4 6.4 0.0 5.5 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain HAT PF02184.16 CDF40537.1 - 0.0055 16.6 3.6 48 4.0 0.0 5.4 5 0 0 5 5 5 0 HAT (Half-A-TPR) repeat Cytochrom_C_2 PF01322.20 CDF40537.1 - 0.0057 17.5 1.2 20 6.1 0.0 3.5 3 0 0 3 3 3 0 Cytochrome C' NARP1 PF12569.8 CDF40537.1 - 0.023 13.6 0.0 8 5.2 0.0 3.3 2 1 1 4 4 4 0 NMDA receptor-regulated protein 1 DUF4192 PF13830.6 CDF40537.1 - 0.045 13.8 18.5 0.058 13.4 0.0 4.7 3 2 1 4 4 4 0 Domain of unknown function (DUF4192) Sel1 PF08238.12 CDF40537.1 - 0.62 10.8 8.6 19 6.1 0.0 6.2 7 0 0 7 7 5 0 Sel1 repeat PPR PF01535.20 CDF40537.1 - 1.4 9.4 6.1 41 4.7 0.0 5.6 7 0 0 7 7 5 0 PPR repeat AAA_33 PF13671.6 CDF40539.1 - 7.6e-14 52.1 0.0 1.1e-13 51.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF40539.1 - 6.4e-05 23.5 0.2 0.0002 21.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CDF40539.1 - 0.0005 20.5 0.0 0.00082 19.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDF40539.1 - 0.0016 18.2 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDF40539.1 - 0.0021 18.5 0.1 0.0039 17.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 CDF40539.1 - 0.0033 16.7 0.0 0.0046 16.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_17 PF13207.6 CDF40539.1 - 0.01 16.3 0.9 0.12 12.8 0.8 2.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDF40539.1 - 0.018 15.0 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.12 CDF40539.1 - 0.022 14.0 0.1 0.03 13.6 0.1 1.6 1 1 0 1 1 1 0 Zeta toxin NTPase_1 PF03266.15 CDF40539.1 - 0.031 14.2 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 CDF40539.1 - 0.033 13.8 0.1 0.087 12.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDF40539.1 - 0.035 13.3 0.1 0.079 12.1 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain SKI PF01202.22 CDF40539.1 - 0.05 13.7 0.1 0.24 11.5 0.0 2.1 2 1 1 3 3 3 0 Shikimate kinase Hpr_kinase_C PF07475.12 CDF40539.1 - 0.054 13.0 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Lac_bphage_repr PF06543.12 CDF40539.1 - 0.06 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor TsaE PF02367.17 CDF40539.1 - 0.073 13.1 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KTI12 PF08433.10 CDF40539.1 - 0.083 12.3 0.1 3.4 7.0 0.0 2.1 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ATPase PF06745.13 CDF40539.1 - 0.1 12.0 0.1 1.8 7.9 0.1 2.1 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 CDF40539.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CDF40539.1 - 0.15 11.8 0.1 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain HEM4 PF02602.15 CDF40541.1 - 1.4e-43 148.9 0.2 1.7e-43 148.6 0.2 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD AbiEi_1 PF09407.10 CDF40541.1 - 0.076 13.3 0.0 0.82 10.0 0.0 2.1 2 0 0 2 2 2 0 AbiEi antitoxin C-terminal domain tRNA-synt_2c PF01411.19 CDF40542.1 - 3.8e-197 656.2 0.0 5.2e-197 655.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CDF40542.1 - 2.5e-14 53.1 0.0 5.6e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CDF40542.1 - 1.1e-09 38.8 1.7 1.1e-09 38.8 1.7 1.9 2 0 0 2 2 2 1 DHHA1 domain DHquinase_I PF01487.15 CDF40543.1 - 1.8e-49 169.1 0.0 3.2e-49 168.2 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 CDF40543.1 - 5.1e-23 81.1 0.0 1.3e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 CDF40543.1 - 2.2e-10 40.1 1.1 1.4e-09 37.5 1.0 2.5 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 CDF40543.1 - 5.9e-10 39.3 0.0 1.2e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CDF40543.1 - 7.4e-06 26.5 0.3 2e-05 25.1 0.3 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CDF40543.1 - 0.00089 19.5 0.1 0.0027 18.0 0.1 1.9 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 CDF40543.1 - 0.079 12.4 0.3 0.079 12.4 0.3 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Metallophos PF00149.28 CDF40546.1 - 1.8e-33 116.8 0.3 2.9e-33 116.1 0.2 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDF40546.1 - 3.8e-05 24.0 0.1 9.2e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain DM13 PF10517.9 CDF40548.1 - 1.7e-45 153.9 0.0 3.6e-21 75.7 0.0 2.7 2 0 0 2 2 2 2 Electron transfer DM13 DOMON PF03351.17 CDF40548.1 - 3.7e-35 120.8 0.0 2.5e-21 76.2 0.0 2.5 2 0 0 2 2 2 2 DOMON domain Cytochrom_B561 PF03188.16 CDF40548.1 - 1.6e-05 25.1 9.8 2.3e-05 24.6 9.8 1.2 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 CDF40548.1 - 0.00062 19.5 4.1 0.00062 19.5 4.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DUF568 PF04526.13 CDF40548.1 - 0.003 18.3 0.0 0.0065 17.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF568) ABC2_membrane PF01061.24 CDF40548.1 - 0.29 10.5 3.3 0.19 11.1 1.9 1.4 1 1 0 1 1 1 0 ABC-2 type transporter Asp PF00026.23 CDF40549.1 - 2.7e-27 96.0 0.0 3.4e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 CDF40549.1 - 8.9e-06 25.6 0.0 6.5e-05 22.8 0.0 2.3 3 0 0 3 3 3 1 Xylanase inhibitor C-terminal Rubi_NSP_C PF12601.8 CDF40549.1 - 0.091 12.9 1.0 0.28 11.3 0.1 2.3 2 0 0 2 2 2 0 Rubivirus non-structural protein peroxidase PF00141.23 CDF40551.1 - 2.8e-45 154.8 0.0 4e-45 154.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Abhydrolase_1 PF00561.20 CDF40552.1 - 5.5e-18 65.5 0.0 8.2e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF40552.1 - 5.5e-10 40.2 0.0 6.5e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF40552.1 - 0.032 13.5 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF1057 PF06342.12 CDF40552.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) BPD_transp_1 PF00528.22 CDF40553.1 - 4e-26 91.9 41.4 9.9e-15 54.7 16.9 3.8 2 2 2 4 4 4 2 Binding-protein-dependent transport system inner membrane component Abhydrolase_1 PF00561.20 CDF40554.1 - 1.4e-17 64.2 0.0 2.1e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF40554.1 - 6.2e-10 40.1 0.0 8.1e-10 39.7 0.0 1.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDF40554.1 - 0.0033 16.7 0.0 0.0044 16.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 CDF40554.1 - 0.058 12.4 0.0 0.089 11.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) MCM PF00493.23 CDF40555.1 - 1.9e-98 328.0 0.1 4.5e-98 326.8 0.1 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CDF40555.1 - 9.3e-35 119.2 0.1 1.6e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDF40555.1 - 2e-26 92.2 1.3 5.7e-26 90.8 1.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDF40555.1 - 1.2e-09 38.7 0.0 2.5e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CDF40555.1 - 3.6e-05 23.3 0.0 0.00023 20.6 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDF40555.1 - 0.0039 17.1 0.0 0.0082 16.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDF40555.1 - 0.085 12.9 0.0 0.28 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 CDF40555.1 - 0.12 13.0 3.0 0.15 12.7 1.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal ABC_tran PF00005.27 CDF40556.1 - 3.5e-25 89.1 0.1 1e-24 87.6 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 CDF40556.1 - 6.7e-21 74.8 18.9 9.6e-21 74.3 18.9 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 CDF40556.1 - 2.3e-09 37.5 0.1 8.1e-08 32.4 0.0 2.2 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 CDF40556.1 - 0.00014 22.5 0.0 0.00031 21.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) DUF4271 PF14093.6 CDF40556.1 - 0.041 13.8 10.6 0.077 12.9 10.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) AAA_23 PF13476.6 CDF40556.1 - 0.079 13.4 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 CDF40556.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase SMC_N PF02463.19 CDF40556.1 - 0.14 11.5 0.0 1.3 8.4 0.0 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF805 PF05656.14 CDF40556.1 - 0.8 10.1 5.5 3.1 8.2 5.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF805) DUF2070 PF09843.9 CDF40556.1 - 6.3 5.0 7.3 9.1 4.4 7.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ABC_tran PF00005.27 CDF40558.1 - 3.5e-26 92.4 0.0 8e-26 91.2 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 CDF40558.1 - 3.6e-22 78.9 12.6 5e-22 78.5 12.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 CDF40558.1 - 1.3e-06 28.5 0.1 0.00069 19.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDF40558.1 - 0.00018 22.1 0.1 0.00036 21.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF40558.1 - 0.00046 19.9 0.1 0.001 18.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDF40558.1 - 0.0019 18.2 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CDF40558.1 - 0.025 14.7 0.0 0.058 13.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CDF40558.1 - 0.059 13.7 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CDF40558.1 - 0.13 11.6 0.1 0.28 10.5 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC2_membrane PF01061.24 CDF40558.1 - 3.5 7.0 18.5 0.56 9.6 13.9 2.0 2 0 0 2 2 2 0 ABC-2 type transporter TrmO PF01980.16 CDF40559.1 - 6.7e-27 94.1 0.0 1.1e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 tRNA-methyltransferase O Sod_Cu PF00080.20 CDF40562.1 - 8e-28 97.4 0.3 1e-27 97.0 0.3 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) BRK PF07533.16 CDF40565.1 - 1.1e-22 79.3 3.6 1.5e-11 43.7 0.6 2.5 2 0 0 2 2 2 2 BRK domain Ribosomal_S13_N PF08069.12 CDF40565.1 - 0.11 12.5 1.3 11 6.2 0.1 3.4 3 0 0 3 3 3 0 Ribosomal S13/S15 N-terminal domain Sel1 PF08238.12 CDF40568.1 - 2e-05 25.1 0.1 0.047 14.4 0.0 2.5 3 0 0 3 3 3 2 Sel1 repeat HetR_C PF18460.1 CDF40568.1 - 0.036 14.0 0.6 0.33 10.9 0.1 1.9 1 1 1 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain GidB PF02527.15 CDF40571.1 - 1.6e-23 83.0 0.0 2e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MTS PF05175.14 CDF40571.1 - 0.025 14.2 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 CDF40571.1 - 0.2 11.4 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase TAFH PF07531.14 CDF40572.1 - 0.031 14.4 0.1 1.6 8.9 0.0 2.3 1 1 1 2 2 2 0 NHR1 homology to TAF CDK5_activator PF03261.15 CDF40573.1 - 1.2 8.6 5.5 1.3 8.5 5.5 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DASH_Spc19 PF08287.11 CDF40573.1 - 2.4 8.0 14.8 2.5 8.0 13.9 1.5 1 1 0 1 1 1 0 Spc19 DUF3807 PF12720.7 CDF40573.1 - 6.1 7.1 15.6 11 6.2 15.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Folliculin PF11704.8 CDF40573.1 - 9.9 6.0 10.6 21 5.0 10.6 1.7 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Golgin_A5 PF09787.9 CDF40574.1 - 0.009 15.5 0.0 0.011 15.2 0.0 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 Ribosomal_L30 PF00327.20 CDF40580.1 - 1.4e-18 66.5 1.0 2.1e-18 66.0 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Transcrip_reg PF01709.20 CDF40581.1 - 2.7e-68 230.0 2.9 3.1e-68 229.8 2.9 1.0 1 0 0 1 1 1 1 Transcriptional regulator WD40 PF00400.32 CDF40582.1 - 3.7e-34 116.2 21.9 5.9e-08 33.3 0.2 6.4 6 0 0 6 6 5 4 WD domain, G-beta repeat NB-ARC PF00931.22 CDF40582.1 - 2.3e-13 49.9 0.0 4.3e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.7 CDF40582.1 - 1.2e-10 41.5 1.0 0.22 11.8 0.0 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDF40582.1 - 1.6e-05 23.8 0.6 1.6 7.2 0.0 3.9 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Me-amine-dh_H PF06433.11 CDF40582.1 - 0.00012 21.0 0.2 0.084 11.7 0.0 2.4 1 1 1 2 2 2 2 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 CDF40582.1 - 0.0004 20.0 10.8 0.0059 16.2 5.4 2.8 1 1 1 2 2 2 2 PQQ-like domain Peptidase_S9_N PF02897.15 CDF40582.1 - 0.0057 15.5 2.4 0.53 9.0 0.1 3.1 1 1 2 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain PQQ PF01011.21 CDF40582.1 - 0.029 14.3 4.2 24 5.1 0.1 4.7 4 1 0 4 4 4 0 PQQ enzyme repeat PQQ_3 PF13570.6 CDF40582.1 - 0.057 13.9 3.2 32 5.2 0.1 4.4 4 0 0 4 4 4 0 PQQ-like domain Ge1_WD40 PF16529.5 CDF40582.1 - 0.064 12.2 0.3 18 4.2 0.0 3.5 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 CDF40582.1 - 0.11 12.7 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain PTN13_u3 PF16599.5 CDF40582.1 - 0.12 12.4 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ WD40_like PF17005.5 CDF40582.1 - 0.2 11.0 0.0 30 3.8 0.0 2.9 2 1 0 2 2 2 0 WD40-like domain SWIRM PF04433.17 CDF40586.1 - 0.13 12.6 0.0 0.14 12.5 0.0 1.0 1 0 0 1 1 1 0 SWIRM domain PRP8_domainIV PF12134.8 CDF40586.1 - 0.19 11.4 0.0 0.19 11.4 0.0 1.0 1 0 0 1 1 1 0 PRP8 domain IV core DNA_topoisoIV PF00521.20 CDF40587.1 - 4.1e-144 480.6 0.0 5e-144 480.3 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CDF40587.1 - 4.8e-54 179.6 8.6 1.2e-13 50.3 0.1 6.6 6 0 0 6 6 6 6 DNA gyrase C-terminal domain, beta-propeller DnaJ_C PF01556.18 CDF40588.1 - 2.5e-37 128.2 0.0 3.7e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDF40588.1 - 7.5e-23 80.4 1.0 1.2e-22 79.8 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDF40588.1 - 5.1e-11 42.8 18.1 1.3e-10 41.4 18.1 1.8 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CDF40588.1 - 0.0059 16.5 11.2 0.085 12.8 1.8 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Aldedh PF00171.22 CDF40589.1 - 7.8e-15 54.3 11.2 2.8e-08 32.7 8.3 2.4 2 1 0 2 2 2 2 Aldehyde dehydrogenase family ATP-synt PF00231.19 CDF40590.1 - 1.5e-85 287.3 0.0 1.7e-85 287.2 0.0 1.0 1 0 0 1 1 1 1 ATP synthase UCH PF00443.29 CDF40592.1 - 2.6e-27 95.9 0.0 3.1e-27 95.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF40592.1 - 1.4e-10 41.2 0.0 3e-10 40.2 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CDF40592.1 - 0.0011 18.5 1.5 1.2 8.5 0.1 2.6 3 0 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase NAD_binding_10 PF13460.6 CDF40594.1 - 1.2e-32 113.3 0.0 1.4e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CDF40594.1 - 1.1e-06 27.8 0.0 2e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDF40594.1 - 1.2e-05 24.9 0.0 4.7e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CDF40594.1 - 1.9e-05 24.3 0.0 8.7e-05 22.2 0.0 2.0 1 1 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CDF40594.1 - 8.5e-05 21.8 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CDF40594.1 - 0.0099 16.1 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CDF40594.1 - 0.044 13.9 0.1 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 CDF40594.1 - 0.052 13.0 0.1 0.082 12.3 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 CDF40594.1 - 0.097 12.6 0.2 0.41 10.6 0.1 1.9 2 0 0 2 2 2 0 KR domain GDP_Man_Dehyd PF16363.5 CDF40594.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ABC2_membrane PF01061.24 CDF40597.1 - 2.2e-40 138.3 16.5 3.3e-40 137.8 16.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CDF40597.1 - 2.2e-23 83.3 0.0 3.4e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CDF40597.1 - 3.5e-10 39.5 21.1 5.4e-10 38.9 21.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.6 CDF40597.1 - 2e-07 31.6 0.1 4.8e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDF40597.1 - 0.00056 19.9 0.1 0.001 19.0 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase T2SSE PF00437.20 CDF40597.1 - 0.022 13.9 0.0 0.032 13.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_21 PF13304.6 CDF40597.1 - 0.028 14.3 1.4 0.67 9.7 0.0 2.3 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CDF40597.1 - 0.045 14.0 0.1 0.11 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDF40597.1 - 0.067 13.3 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 CDF40597.1 - 0.14 12.4 0.1 0.42 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CDF40597.1 - 0.17 11.1 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 CDF40597.1 - 0.21 10.7 0.0 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase DLIC PF05783.11 CDF40597.1 - 0.45 9.3 0.0 0.45 9.3 0.0 1.5 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) DUF1289 PF06945.13 CDF40598.1 - 0.025 14.4 0.2 0.03 14.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) zf-BED PF02892.15 CDF40598.1 - 1.5 8.9 5.9 4.4 7.4 5.9 1.7 1 1 0 1 1 1 0 BED zinc finger APH PF01636.23 CDF40599.1 - 5.2e-08 33.1 0.1 9.4e-08 32.3 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family PAP2 PF01569.21 CDF40600.1 - 0.0014 18.4 0.7 0.01 15.6 0.7 2.0 1 1 0 1 1 1 1 PAP2 superfamily VirC2 PF07181.11 CDF40601.1 - 0.16 11.4 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 VirC2 protein DUF3961 PF13106.6 CDF40601.1 - 0.21 11.3 1.0 0.55 9.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3961) Sec5 PF15469.6 CDF40602.1 - 6.6e-05 22.8 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 DUF577 PF04510.12 CDF40603.1 - 0.12 12.3 0.8 6.3 6.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF577) IBN_N PF03810.19 CDF40605.1 - 1.5e-05 24.8 0.0 0.24 11.3 0.0 2.4 2 0 0 2 2 2 2 Importin-beta N-terminal domain TTSSLRR PF12468.8 CDF40605.1 - 0.00047 20.3 0.8 2.2 8.6 0.0 3.2 3 0 0 3 3 3 2 Type III secretion system leucine rich repeat protein DUF4290 PF14123.6 CDF40605.1 - 0.001 18.7 0.0 1.2 8.6 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4290) Methyltransf_PK PF05891.12 CDF40605.1 - 0.0082 15.7 0.6 1.8 8.0 0.1 2.2 2 0 0 2 2 2 2 AdoMet dependent proline di-methyltransferase MADF_DNA_bdg PF10545.9 CDF40605.1 - 0.096 13.0 0.1 26 5.2 0.0 2.7 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like LNS2 PF08235.13 CDF40605.1 - 0.1 12.1 0.0 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) TFIIS_C PF01096.18 CDF40606.1 - 2.7e-19 68.7 7.4 2.7e-19 68.7 7.4 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 CDF40606.1 - 0.037 13.7 1.8 0.049 13.3 0.2 1.9 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain PhoLip_ATPase_C PF16212.5 CDF40607.1 - 2.9e-60 204.1 7.0 4.2e-60 203.6 7.0 1.2 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CDF40607.1 - 1.3e-11 45.2 0.3 4.8e-06 27.0 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDF40607.1 - 0.0048 16.7 0.0 0.024 14.4 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDF40607.1 - 0.08 13.0 0.2 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Ribosomal_L14 PF00238.19 CDF40609.1 - 9.7e-32 109.6 1.2 1.1e-31 109.4 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Peptidase_C14 PF00656.22 CDF40610.1 - 1.7e-48 165.7 0.0 2.2e-48 165.4 0.0 1.1 1 0 0 1 1 1 1 Caspase domain zf-C2H2_2 PF12756.7 CDF40611.1 - 1.4e-28 99.1 0.5 1.1e-23 83.4 0.0 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CDF40611.1 - 1.9e-10 40.8 4.0 2.7e-06 27.5 1.2 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDF40611.1 - 7.7e-06 26.1 5.5 1.4e-05 25.3 1.4 2.9 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 CDF40611.1 - 0.00027 21.2 2.4 0.5 10.9 0.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF40611.1 - 0.00029 21.4 0.9 0.084 13.8 0.4 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger DUF4982 PF16355.5 CDF40611.1 - 0.019 14.9 0.4 0.15 12.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4982) zf-C2H2_6 PF13912.6 CDF40611.1 - 0.036 14.1 1.7 0.37 10.8 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-DBF PF07535.12 CDF40611.1 - 2 8.6 6.3 0.48 10.6 0.3 2.6 3 0 0 3 3 3 0 DBF zinc finger Histone_H2A_C PF16211.5 CDF40612.1 - 3e-18 65.2 0.2 3e-18 65.2 0.2 1.7 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 CDF40612.1 - 9.2e-18 64.9 0.0 1.3e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF40612.1 - 0.00011 22.4 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDF40614.1 - 2.4e-20 73.2 0.1 3e-20 72.9 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF40614.1 - 3.2e-07 30.5 0.5 7.5e-07 29.3 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CDF40614.1 - 0.0095 16.4 0.0 0.017 15.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 CDF40614.1 - 0.019 15.0 0.1 0.025 14.6 0.1 1.3 1 0 0 1 1 1 0 YscO-like protein Ribonuc_L-PSP PF01042.21 CDF40615.1 - 4.7e-59 197.7 0.0 5.5e-34 116.8 0.0 2.0 2 0 0 2 2 2 2 Endoribonuclease L-PSP PQQ_3 PF13570.6 CDF40615.1 - 0.013 16.0 3.6 0.83 10.2 2.4 2.6 2 0 0 2 2 2 0 PQQ-like domain BON PF04972.17 CDF40615.1 - 0.013 15.8 0.9 4 7.8 0.0 3.3 3 0 0 3 3 3 0 BON domain PapC_C PF13953.6 CDF40615.1 - 0.13 12.1 0.3 1.8 8.4 0.0 2.7 3 0 0 3 3 3 0 PapC C-terminal domain RNase_PH PF01138.21 CDF40616.1 - 1.6e-26 93.4 0.4 3.5e-26 92.3 0.1 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDF40616.1 - 6.5e-06 26.1 0.2 1.1e-05 25.4 0.2 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 UreF PF01730.16 CDF40616.1 - 0.0084 16.7 0.6 0.02 15.5 0.7 1.7 1 1 0 1 1 1 1 UreF ATP-synt_ab PF00006.25 CDF40617.1 - 2.4e-60 203.8 0.0 3.8e-60 203.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDF40617.1 - 2.9e-23 82.2 1.6 5.6e-23 81.3 1.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CDF40617.1 - 0.034 13.5 0.2 0.065 12.6 0.2 1.5 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 CDF40617.1 - 0.056 13.4 0.0 0.14 12.0 0.0 1.6 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 CDF40617.1 - 0.2 10.8 0.1 0.35 10.0 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.6 CDF40617.1 - 0.41 11.0 1.7 0.59 10.5 0.1 2.1 3 0 0 3 3 3 0 AAA domain Methyltransf_11 PF08241.12 CDF40618.1 - 1.3e-23 83.5 0.0 3.1e-23 82.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF40618.1 - 2.4e-20 73.1 0.0 5.2e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF40618.1 - 1.9e-16 60.6 0.0 3.6e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDF40618.1 - 9e-16 58.0 0.0 1.2e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CDF40618.1 - 2.6e-15 56.7 0.0 4.8e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF40618.1 - 9.4e-15 54.7 0.0 1.7e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF40618.1 - 2.3e-09 37.0 0.0 4.9e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CDF40618.1 - 0.00015 21.4 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 CDF40618.1 - 0.00017 21.8 0.0 0.00096 19.3 0.0 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase MetW PF07021.12 CDF40618.1 - 0.00021 20.9 0.0 0.00037 20.2 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 CDF40618.1 - 0.00057 19.7 0.0 0.0013 18.6 0.0 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_29 PF03141.16 CDF40618.1 - 0.0015 17.2 0.0 0.0021 16.7 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_PK PF05891.12 CDF40618.1 - 0.0016 18.0 0.0 0.0035 16.9 0.0 1.6 1 1 1 2 2 2 1 AdoMet dependent proline di-methyltransferase ADH_zinc_N PF00107.26 CDF40618.1 - 0.038 14.0 0.0 0.093 12.7 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase GCD14 PF08704.10 CDF40618.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Rad60-SLD_2 PF13881.6 CDF40621.1 - 2.8e-09 37.0 0.1 4e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDF40621.1 - 0.0028 17.4 0.2 0.0094 15.7 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin family F-box-like PF12937.7 CDF40622.1 - 7.1e-08 32.2 0.0 3e-07 30.2 0.0 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDF40622.1 - 5e-07 29.4 0.3 2e-06 27.5 0.3 2.1 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 CDF40622.1 - 0.0066 16.8 5.3 0.25 11.8 0.1 5.1 5 2 1 6 6 6 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDF40622.1 - 0.055 13.5 7.9 55 4.2 0.0 6.5 7 0 0 7 7 7 0 Leucine Rich repeat UCH_1 PF13423.6 CDF40624.1 - 1.7e-55 188.9 0.0 2.1e-55 188.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 CDF40624.1 - 6.2e-18 65.9 0.0 1.1e-17 65.1 0.0 1.4 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 CDF40624.1 - 3.4e-05 23.5 0.0 0.29 10.6 0.0 2.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PIF1 PF05970.14 CDF40625.1 - 7.8e-91 305.0 0.0 1.2e-62 212.3 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF40625.1 - 1.3e-59 201.6 0.0 2.4e-59 200.7 0.0 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40625.1 - 1.9e-13 50.5 0.0 3.7e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF40625.1 - 0.0096 16.3 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF40625.1 - 0.054 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF40625.1 - 0.082 10.8 0.0 0.13 10.2 0.0 1.2 1 0 0 1 1 1 0 Helicase Ion_trans_2 PF07885.16 CDF40626.1 - 3.6e-15 55.7 5.2 3.6e-15 55.7 5.2 1.8 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 CDF40626.1 - 1.5e-13 50.5 6.6 2e-13 50.2 6.6 1.1 1 0 0 1 1 1 1 Ion transport protein DZR PF12773.7 CDF40626.1 - 0.044 13.8 0.6 0.098 12.7 0.6 1.5 1 0 0 1 1 1 0 Double zinc ribbon NOB1_Zn_bind PF08772.11 CDF40626.1 - 0.18 12.0 1.1 0.38 10.9 1.1 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zf-ribbon_3 PF13248.6 CDF40626.1 - 0.35 10.4 4.6 1.3 8.6 1.8 2.4 2 1 0 2 2 2 0 zinc-ribbon domain RabGAP-TBC PF00566.18 CDF40627.1 - 1.2e-53 181.9 0.2 4.1e-53 180.2 0.2 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DEAD PF00270.29 CDF40628.1 - 2.2e-36 125.3 0.0 4.3e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF40628.1 - 1.3e-16 60.9 0.0 7.2e-15 55.3 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF40628.1 - 2.5e-05 24.3 0.0 5.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_L28e PF01778.17 CDF40629.1 - 1.4e-36 125.8 3.0 1.4e-36 125.8 3.0 1.9 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 CDF40629.1 - 4.2e-26 91.5 11.6 4.2e-26 91.5 11.6 1.8 2 0 0 2 2 2 1 Mak16 protein C-terminal region Exonuc_VII_L PF02601.15 CDF40629.1 - 0.098 12.2 2.1 0.14 11.7 2.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Astro_capsid_p PF12226.8 CDF40629.1 - 0.29 10.2 3.6 0.51 9.4 3.6 1.6 1 0 0 1 1 1 0 Turkey astrovirus capsid protein LRR_4 PF12799.7 CDF40631.1 - 2e-07 31.2 4.0 0.036 14.5 0.1 5.7 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDF40631.1 - 2.6e-05 23.9 0.5 12 6.3 0.0 6.8 8 0 0 8 8 8 1 Leucine Rich repeat LRR_8 PF13855.6 CDF40631.1 - 0.082 12.7 6.4 1.8 8.4 0.7 4.6 5 2 0 5 5 5 0 Leucine rich repeat LRR_1 PF00560.33 CDF40631.1 - 3.4 8.6 10.2 8.5 7.4 0.0 5.9 6 2 0 6 6 6 0 Leucine Rich Repeat RRM_1 PF00076.22 CDF40632.1 - 1.4e-16 60.0 0.0 2.1e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zinc_ribbon_4 PF13717.6 CDF40632.1 - 2.1e-07 30.8 0.9 3.5e-07 30.0 0.9 1.4 1 0 0 1 1 1 1 zinc-ribbon domain NOB1_Zn_bind PF08772.11 CDF40632.1 - 0.058 13.6 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_5 PF13719.6 CDF40632.1 - 0.068 12.9 1.0 0.14 12.0 1.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain RRM_Rrp7 PF17799.1 CDF40632.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain F-box-like PF12937.7 CDF40633.1 - 4e-10 39.4 2.2 7.3e-09 35.4 0.0 2.6 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 CDF40633.1 - 1.5e-05 25.2 6.1 0.46 11.0 0.1 5.9 5 2 1 6 6 6 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDF40633.1 - 0.00011 21.9 1.1 8.8 6.7 0.0 6.4 7 0 0 7 7 7 1 Leucine Rich repeat F-box PF00646.33 CDF40633.1 - 0.00057 19.7 0.0 0.0021 17.9 0.0 2.0 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.33 CDF40633.1 - 0.0046 17.3 5.0 10 7.1 0.0 5.6 5 1 0 5 5 5 1 Leucine Rich Repeat F-box_4 PF15966.5 CDF40633.1 - 0.025 14.4 0.7 0.21 11.4 0.0 2.5 2 0 0 2 2 2 0 F-box F-box-like_2 PF13013.6 CDF40633.1 - 0.051 13.5 0.1 2.5 8.1 0.1 3.2 2 2 0 2 2 2 0 F-box-like domain G-patch_2 PF12656.7 CDF40635.1 - 9.7e-16 57.6 5.6 2.4e-15 56.4 0.2 3.3 3 0 0 3 3 3 1 G-patch domain G-patch PF01585.23 CDF40635.1 - 0.009 15.9 0.7 0.045 13.6 0.7 2.3 2 0 0 2 2 2 1 G-patch domain RHD3 PF05879.12 CDF40636.1 - 9.5e-71 239.0 0.0 1.2e-70 238.6 0.0 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 CDF40636.1 - 0.00056 20.0 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF5456 PF17539.2 CDF40636.1 - 0.017 15.0 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5456) Dynamin_N PF00350.23 CDF40636.1 - 0.025 14.6 0.1 0.076 13.1 0.1 1.8 2 0 0 2 2 2 0 Dynamin family GBP PF02263.19 CDF40636.1 - 0.2 10.9 0.0 0.47 9.7 0.0 1.6 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain HTH_Tnp_Tc3_1 PF11427.8 CDF40637.1 - 2.3e-10 40.1 0.0 4.1e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF40637.1 - 0.0002 21.0 0.0 0.00037 20.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF40637.1 - 0.00046 19.9 0.0 0.00098 18.9 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain DUF5320 PF17253.2 CDF40638.1 - 0.021 15.9 7.5 0.09 13.9 3.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DDE_Tnp_1_7 PF13843.6 CDF40638.1 - 0.068 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Transposase IS4 NAM-associated PF14303.6 CDF40639.1 - 1.5e-05 25.7 0.4 4.7e-05 24.2 0.4 1.9 1 1 0 1 1 1 1 No apical meristem-associated C-terminal domain Plant_tran PF04827.14 CDF40641.1 - 2e-73 246.3 0.0 2.7e-73 246.0 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF40641.1 - 1.4e-10 41.0 0.0 2.6e-10 40.2 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_1 PF03184.19 CDF40642.1 - 1.2e-05 25.0 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF747 PF05346.11 CDF40643.1 - 8.6e-88 294.9 11.6 1.1e-87 294.5 11.6 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family APH PF01636.23 CDF40644.1 - 2.9e-32 112.5 0.0 7e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.24 CDF40644.1 - 3.3e-32 111.8 2.7 6.2e-32 110.9 2.7 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDF40644.1 - 6.3e-19 68.0 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CDF40644.1 - 9.3e-14 52.0 0.2 1.9e-13 51.1 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDF40644.1 - 3.4e-10 40.3 3.4 7.2e-10 39.3 3.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain EcKinase PF02958.20 CDF40644.1 - 1.3e-06 28.0 0.0 4.6e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 CDF40644.1 - 0.0007 19.2 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 CDF40644.1 - 0.0022 17.6 0.0 0.66 9.6 0.0 2.3 2 0 0 2 2 2 2 RIO1 family DUF1679 PF07914.11 CDF40644.1 - 0.0042 16.0 0.0 0.0079 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Anoctamin PF04547.12 CDF40645.1 - 2.3e-30 105.9 0.0 2.3e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel COX1 PF00115.20 CDF40645.1 - 0.067 12.0 1.2 0.2 10.5 0.0 1.8 2 0 0 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I Sel1 PF08238.12 CDF40648.1 - 2e-06 28.3 0.0 0.014 16.0 0.0 3.4 3 0 0 3 3 3 2 Sel1 repeat DUF3138 PF11336.8 CDF40650.1 - 0.14 10.8 1.4 0.23 10.0 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Asp_Arg_Hydrox PF05118.15 CDF40652.1 - 5.8e-35 120.5 0.2 9.1e-35 119.8 0.2 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase UPA PF17217.3 CDF40653.1 - 0.076 12.9 0.0 0.2 11.6 0.0 1.6 2 0 0 2 2 2 0 UPA domain Sec23_trunk PF04811.15 CDF40654.1 - 0.001 18.7 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Gelsolin PF00626.22 CDF40654.1 - 0.0025 17.7 0.0 0.0066 16.3 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 CDF40654.1 - 0.0033 17.4 0.1 0.0068 16.4 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 CDF40654.1 - 0.19 12.5 0.0 0.44 11.3 0.0 1.6 1 0 0 1 1 1 0 Sec23/Sec24 beta-sandwich domain Tctex-1 PF03645.13 CDF40655.1 - 4.1e-20 71.9 4.1 6.2e-20 71.4 4.1 1.3 1 0 0 1 1 1 1 Tctex-1 family zf-C3HC4_3 PF13920.6 CDF40657.1 - 1.4e-07 31.2 1.3 2.3e-07 30.6 1.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF40657.1 - 3.7e-06 26.7 1.4 1.5e-05 24.7 1.2 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CDF40657.1 - 3.1e-05 23.9 1.6 5.8e-05 23.0 1.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDF40657.1 - 3.1e-05 23.8 2.2 5.5e-05 22.9 2.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDF40657.1 - 4.8e-05 23.6 1.6 8.6e-05 22.8 1.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDF40657.1 - 0.00035 20.3 1.7 0.00068 19.4 1.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDF40657.1 - 0.00088 19.5 0.3 0.0021 18.3 0.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Fib_alpha PF08702.10 CDF40657.1 - 0.0012 19.1 1.2 0.0012 19.1 1.2 6.0 3 2 4 8 8 8 1 Fibrinogen alpha/beta chain family zf-RING_UBOX PF13445.6 CDF40657.1 - 0.008 16.2 1.6 0.02 14.9 0.3 2.1 1 1 1 2 2 2 1 RING-type zinc-finger Rad50_zn_hook PF04423.14 CDF40657.1 - 0.026 14.4 0.0 0.026 14.4 0.0 4.2 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-Nse PF11789.8 CDF40657.1 - 0.068 13.0 1.7 0.12 12.3 0.8 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 CDF40657.1 - 0.18 11.6 0.7 0.34 10.7 0.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 CDF40657.1 - 0.33 11.2 1.5 0.61 10.3 1.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Exonuc_VII_S PF02609.16 CDF40657.1 - 5.2 7.2 11.2 0.34 11.0 3.2 3.3 2 1 1 3 3 3 0 Exonuclease VII small subunit Peptidase_C98 PF15499.6 CDF40657.1 - 5.3 6.4 17.1 0.017 14.6 1.2 3.5 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Ala_racemase_N PF01168.20 CDF40659.1 - 8.5e-27 94.2 0.0 1e-26 94.0 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain MAD PF05557.13 CDF40660.1 - 3.5e-34 118.2 69.1 3.7e-33 114.8 69.1 2.9 1 1 0 1 1 1 1 Mitotic checkpoint protein DUF4407 PF14362.6 CDF40660.1 - 0.0045 16.4 6.5 0.0045 16.4 6.5 5.1 3 1 1 4 4 4 1 Domain of unknown function (DUF4407) WD40_alt PF14077.6 CDF40660.1 - 0.034 14.0 12.4 0.56 10.1 0.7 4.8 5 0 0 5 5 5 0 Alternative WD40 repeat motif Myb_DNA-bind_3 PF12776.7 CDF40660.1 - 0.89 10.6 8.2 3.6 8.7 0.1 4.0 3 1 1 4 4 4 0 Myb/SANT-like DNA-binding domain GLE1 PF07817.13 CDF40660.1 - 1.4 8.0 11.9 2.9 7.0 1.1 3.9 3 0 0 3 3 3 0 GLE1-like protein NPV_P10 PF05531.12 CDF40660.1 - 8.6 6.9 15.8 20 5.7 0.0 5.8 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein Pentapeptide PF00805.22 CDF40661.1 - 2.1e-18 65.6 8.1 4.1e-07 29.5 2.9 3.4 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CDF40661.1 - 9.3e-12 44.9 0.1 3.4e-06 27.1 0.1 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CDF40661.1 - 5.6e-10 39.2 7.8 0.00087 19.4 8.0 3.4 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) PsbQ PF05757.11 CDF40661.1 - 0.4 10.4 2.2 0.63 9.7 2.2 1.2 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) EamA PF00892.20 CDF40662.1 - 4e-13 49.7 3.3 4e-13 49.7 3.3 1.7 2 0 0 2 2 2 1 EamA-like transporter family YrhC PF14143.6 CDF40662.1 - 0.022 14.8 0.7 0.44 10.7 0.0 2.6 1 1 1 2 2 2 0 YrhC-like protein CRT-like PF08627.10 CDF40663.1 - 8.5e-09 34.8 9.8 2.3e-08 33.4 1.2 2.1 1 1 1 2 2 2 2 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 CDF40663.1 - 4.8e-07 29.6 11.0 1e-06 28.5 11.0 1.6 1 1 0 1 1 1 1 Solute carrier family 35 TPT PF03151.16 CDF40663.1 - 2.1e-05 24.0 1.9 3.7e-05 23.2 1.9 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CDF40663.1 - 5.9e-05 22.4 2.1 0.00014 21.2 1.9 1.6 2 1 0 2 2 2 1 UAA transporter family EamA PF00892.20 CDF40663.1 - 7.7e-05 22.9 4.2 7.7e-05 22.9 4.2 4.0 2 2 0 3 3 3 1 EamA-like transporter family PUNUT PF16913.5 CDF40663.1 - 0.00075 18.8 1.1 0.00075 18.8 1.1 1.7 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport Nuc_sug_transp PF04142.15 CDF40663.1 - 0.0016 17.7 4.6 0.0033 16.6 3.8 1.9 2 1 1 3 3 3 1 Nucleotide-sugar transporter Nucleotid_trans PF03407.16 CDF40666.1 - 6.9e-14 52.3 0.0 1.1e-13 51.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Methyltrans_SAM PF10672.9 CDF40667.1 - 1.5e-17 63.7 0.0 2.4e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Methyltransf_31 PF13847.6 CDF40667.1 - 2.6e-12 46.8 0.0 4.8e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CDF40667.1 - 1.4e-11 44.2 0.0 2.1e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_3 PF01596.17 CDF40667.1 - 1.3e-09 37.5 0.0 2e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.14 CDF40667.1 - 1.7e-09 37.4 0.0 2.7e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDF40667.1 - 2.7e-09 36.9 0.0 5e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 CDF40667.1 - 1.7e-08 34.4 0.1 5.6e-08 32.7 0.1 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 CDF40667.1 - 1.9e-08 34.9 0.0 4.1e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDF40667.1 - 3.5e-07 30.2 0.0 5.8e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PUA_3 PF17785.1 CDF40667.1 - 1.2e-06 28.2 0.0 2.8e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 PUA-like domain PrmA PF06325.13 CDF40667.1 - 0.00039 19.9 0.1 0.00058 19.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TRM PF02005.16 CDF40667.1 - 0.00041 19.6 0.0 0.00083 18.6 0.0 1.4 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltr_RsmB-F PF01189.17 CDF40667.1 - 0.00074 19.2 0.1 0.0068 16.1 0.1 2.1 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_11 PF08241.12 CDF40667.1 - 0.0017 19.0 0.1 0.0065 17.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF40667.1 - 0.0034 17.2 0.0 0.0059 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 CDF40667.1 - 0.015 14.8 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Methyltransf_12 PF08242.12 CDF40667.1 - 0.035 14.9 0.0 0.075 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 CDF40667.1 - 0.086 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF43 PF01861.16 CDF40667.1 - 0.088 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain DSBA PF01323.20 CDF40668.1 - 0.0082 15.9 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 2 DSBA-like thioredoxin domain RVT_3 PF13456.6 CDF40674.1 - 0.0046 16.8 0.5 0.033 14.0 0.5 2.0 1 1 0 1 1 1 1 Reverse transcriptase-like zf-C2H2 PF00096.26 CDF40675.1 - 0.035 14.6 4.6 0.074 13.5 4.6 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDF40675.1 - 0.43 11.5 3.9 0.89 10.6 3.9 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Sel1 PF08238.12 CDF40677.1 - 2.1e-49 164.9 6.0 0.0001 22.9 0.2 13.3 14 0 0 14 14 14 10 Sel1 repeat TPR_16 PF13432.6 CDF40677.1 - 0.00018 22.1 18.0 14 6.4 0.2 7.8 7 2 1 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40677.1 - 0.0023 18.2 6.4 39 5.0 0.0 8.2 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40677.1 - 0.011 16.3 14.2 12 6.8 0.1 9.3 11 1 0 11 11 11 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDF40677.1 - 0.024 14.6 17.6 50 4.2 0.0 10.5 13 0 0 13 13 13 0 Tetratricopeptide repeat RIC1 PF07064.13 CDF40677.1 - 0.078 12.4 0.0 4.6 6.6 0.0 2.4 2 0 0 2 2 2 0 RIC1 Fis1_TPR_N PF14852.6 CDF40677.1 - 0.12 12.1 2.1 4.3 7.1 0.1 4.0 4 0 0 4 4 4 0 Fis1 N-terminal tetratricopeptide repeat ComR_TPR PF18710.1 CDF40677.1 - 0.21 11.1 0.0 1.8 8.1 0.0 2.4 3 0 0 3 3 3 0 ComR tetratricopeptide TPR_14 PF13428.6 CDF40677.1 - 2.6 9.1 26.3 45 5.2 0.3 9.4 10 2 1 11 11 11 0 Tetratricopeptide repeat RT_RNaseH PF17917.1 CDF40678.1 - 6.5e-36 122.8 0.1 2.9e-33 114.3 0.0 3.1 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF40678.1 - 1.7e-33 114.6 0.0 6.1e-33 112.8 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF40678.1 - 2.1e-21 76.3 0.0 3.8e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF40678.1 - 3.7e-09 36.5 0.1 7.2e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF40678.1 - 7.3e-05 22.4 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CDF40678.1 - 0.0016 18.2 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Aminoglyc_resit PF10706.9 CDF40680.1 - 0.09 12.5 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase Arm PF00514.23 CDF40682.1 - 2.5e-11 43.2 9.9 1.4e-06 28.1 0.0 6.2 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CDF40682.1 - 1.4e-07 31.2 10.6 0.25 11.7 0.1 6.8 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 CDF40682.1 - 2.9e-05 24.2 1.8 1.4 9.0 0.1 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 CDF40682.1 - 6.3e-05 23.1 1.2 0.036 14.2 0.1 3.2 2 1 1 3 3 3 1 V-ATPase subunit H HEAT_2 PF13646.6 CDF40682.1 - 7.1e-05 23.1 10.6 0.026 14.9 0.5 5.6 3 2 1 5 5 5 1 HEAT repeats CLASP_N PF12348.8 CDF40682.1 - 0.00035 20.2 0.2 0.0017 18.0 0.2 2.1 1 1 1 2 2 2 1 CLASP N terminal DUF3361 PF11841.8 CDF40682.1 - 0.0025 17.8 0.7 0.012 15.6 0.2 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF3361) DCB PF16213.5 CDF40682.1 - 0.01 15.5 0.2 3.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Adaptin_N PF01602.20 CDF40682.1 - 0.023 13.2 3.9 0.14 10.7 0.5 3.0 2 1 2 4 4 4 0 Adaptin N terminal region Atx10homo_assoc PF09759.9 CDF40682.1 - 0.026 14.5 0.2 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 CDF40682.1 - 0.089 13.3 14.4 2.1 8.9 0.1 5.8 6 1 0 6 6 6 0 HEAT-like repeat TIG PF01833.24 CDF40686.1 - 2.2e-10 40.5 0.2 5e-10 39.3 0.2 1.7 1 0 0 1 1 1 1 IPT/TIG domain GSDH PF07995.11 CDF40686.1 - 3.8e-08 33.0 0.0 0.0018 17.7 0.0 2.3 2 0 0 2 2 2 2 Glucose / Sorbosone dehydrogenase 5-FTHF_cyc-lig PF01812.20 CDF40686.1 - 0.071 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family ParD_antitoxin PF03693.14 CDF40690.1 - 0.13 12.7 0.0 35 4.9 0.0 2.7 3 0 0 3 3 3 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Toxin_34 PF08396.10 CDF40691.1 - 0.11 13.2 35.6 0.17 12.6 9.1 3.1 1 1 2 3 3 3 0 Spider toxin omega agatoxin/Tx1 family Peptidase_S49 PF01343.18 CDF40695.1 - 7.3e-24 84.5 0.0 9.2e-24 84.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family S49 SLATT_3 PF18184.1 CDF40697.1 - 0.79 9.9 11.4 2.2 8.4 1.8 2.3 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 DUF4148 PF13663.6 CDF40697.1 - 5 7.4 7.1 2.4 8.4 0.3 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4148) Aminotran_1_2 PF00155.21 CDF40699.1 - 1e-64 219.0 0.0 1.2e-64 218.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4571 PF15137.6 CDF40699.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) HTH_Tnp_Tc3_1 PF11427.8 CDF40700.1 - 3.8e-06 26.7 0.0 7.1e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Tc3 transposase DDE_3 PF13358.6 CDF40700.1 - 6.7e-06 25.9 0.0 1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.6 CDF40700.1 - 0.013 15.3 0.0 0.035 13.9 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Flavin_Reduct PF01613.18 CDF40702.1 - 4.2e-10 39.9 2.0 3.6e-09 36.9 2.0 2.2 1 1 0 1 1 1 1 Flavin reductase like domain WD40 PF00400.32 CDF40704.1 - 1.4e-06 28.9 5.0 0.053 14.4 0.0 5.1 5 1 0 5 5 5 2 WD domain, G-beta repeat PQQ_2 PF13360.6 CDF40704.1 - 6.9e-05 22.5 3.7 0.00017 21.3 0.8 3.0 2 2 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 CDF40704.1 - 0.0023 17.8 9.4 4.1 7.5 0.0 5.3 5 0 0 5 5 5 3 PQQ enzyme repeat PD40 PF07676.12 CDF40704.1 - 1.5 8.9 7.7 18 5.4 0.1 4.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Zip PF02535.22 CDF40705.1 - 2.7e-32 112.3 37.5 2.3e-29 102.7 3.1 3.5 2 1 1 3 3 3 3 ZIP Zinc transporter Herpes_UL6 PF01763.16 CDF40707.1 - 0.095 11.2 0.1 0.19 10.2 0.1 1.4 2 0 0 2 2 2 0 Herpesvirus UL6 like Patatin PF01734.22 CDF40708.1 - 7.4e-24 85.1 0.0 1.4e-23 84.1 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3336 PF11815.8 CDF40708.1 - 1.2e-19 70.4 3.7 2.9e-11 43.3 0.0 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF3336) FG-GAP_2 PF14312.6 CDF40710.1 - 2.9e-15 56.2 19.1 1.6e-08 34.6 0.7 4.6 5 0 0 5 5 5 3 FG-GAP repeat DHR-2 PF06920.13 CDF40710.1 - 0.1 11.2 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Dock homology region 2 Phosphodiest PF01663.22 CDF40711.1 - 3.1e-49 168.5 0.1 3.6e-49 168.2 0.1 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CCT PF06203.14 CDF40713.1 - 6.4e-17 61.3 13.4 1.2e-16 60.5 13.4 1.4 1 0 0 1 1 1 1 CCT motif zf-B_box PF00643.24 CDF40713.1 - 3.7e-06 27.0 0.2 7.7e-06 26.0 0.2 1.5 1 0 0 1 1 1 1 B-box zinc finger N6_N4_Mtase PF01555.18 CDF40714.1 - 3.1e-14 53.2 0.0 1.4e-12 47.8 0.0 2.2 1 1 0 1 1 1 1 DNA methylase SET PF00856.28 CDF40714.1 - 0.004 17.6 0.0 0.023 15.1 0.0 2.2 1 1 0 1 1 1 1 SET domain N6-adenineMlase PF10237.9 CDF40714.1 - 0.015 15.1 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase MethyltransfD12 PF02086.15 CDF40714.1 - 0.14 11.8 0.1 4.1 7.0 0.0 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase UPF0020 PF01170.18 CDF40714.1 - 0.18 11.4 0.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 OrsD PF12013.8 CDF40715.1 - 1.2e-06 29.0 0.8 3.9e-06 27.3 0.2 2.2 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D RabGAP-TBC PF00566.18 CDF40716.1 - 1.3e-17 64.1 0.7 2.2e-17 63.4 0.7 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 CDF40716.1 - 7.7e-05 23.2 0.0 0.00015 22.2 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Bin3 PF06859.12 CDF40718.1 - 1.1e-33 116.0 0.0 1.6e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_23 PF13489.6 CDF40718.1 - 4.5e-11 42.9 0.0 6.7e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF40718.1 - 3.4e-10 40.5 0.2 1e-05 26.1 0.1 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CDF40718.1 - 3.4e-10 40.4 0.2 0.00089 19.9 0.1 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CDF40718.1 - 6e-10 39.8 0.0 1.1e-08 35.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF40718.1 - 1.6e-06 28.0 0.0 0.00096 19.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain NodS PF05401.11 CDF40718.1 - 0.00093 18.9 0.0 0.0029 17.3 0.0 1.7 2 0 0 2 2 2 1 Nodulation protein S (NodS) Methyltransf_18 PF12847.7 CDF40718.1 - 0.0074 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF40718.1 - 0.081 12.5 0.0 4 7.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CDF40718.1 - 0.088 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase His_Phos_1 PF00300.22 CDF40719.1 - 8.3e-19 68.0 0.0 4.3e-18 65.7 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) MMS19_C PF12460.8 CDF40720.1 - 0.00081 18.6 1.2 0.011 14.9 0.2 2.6 2 0 0 2 2 2 1 RNAPII transcription regulator C-terminal IQ PF00612.27 CDF40720.1 - 0.11 12.3 0.3 0.32 10.9 0.3 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF3437 PF11919.8 CDF40720.1 - 0.13 12.1 0.1 0.92 9.5 0.1 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) HEAT PF02985.22 CDF40720.1 - 0.17 12.3 4.4 4.6 7.8 0.1 4.8 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 CDF40720.1 - 0.18 12.3 12.5 2.2 8.9 0.0 4.4 5 0 0 5 5 5 0 HEAT-like repeat PPR_2 PF13041.6 CDF40721.1 - 6.7e-72 237.5 0.1 3.1e-11 43.3 0.0 10.8 6 3 5 11 11 11 10 PPR repeat family PPR PF01535.20 CDF40721.1 - 7e-53 173.3 10.5 8e-07 28.9 0.2 14.0 14 1 0 14 14 14 9 PPR repeat PPR_1 PF12854.7 CDF40721.1 - 6.2e-51 169.8 1.6 1.1e-05 25.0 0.0 11.9 12 0 0 12 12 12 9 PPR repeat PPR_3 PF13812.6 CDF40721.1 - 9.9e-41 137.7 0.1 4.5e-10 39.5 0.0 8.0 4 2 4 9 9 9 8 Pentatricopeptide repeat domain PPR_long PF17177.4 CDF40721.1 - 2.9e-21 75.8 0.1 1.2e-09 37.9 0.0 4.2 3 1 2 5 5 5 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 CDF40721.1 - 0.00023 21.0 0.0 5 7.0 0.0 5.3 5 1 0 5 5 5 1 Mitochondrial ATPase expression FluMu_N PF17891.1 CDF40721.1 - 0.024 14.4 0.0 2.1 8.2 0.0 2.7 2 0 0 2 2 2 0 Mu-like prophage FluMu N-terminal domain RPM2 PF08579.11 CDF40721.1 - 0.033 14.6 0.0 25 5.3 0.0 3.9 4 1 0 4 4 4 0 Mitochondrial ribonuclease P subunit (RPM2) TPR_16 PF13432.6 CDF40721.1 - 0.11 13.2 0.0 23 5.8 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDF40721.1 - 0.37 11.1 2.5 15 5.9 0.0 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Sigma70_r2 PF04542.14 CDF40722.1 - 3.2e-20 71.7 0.1 7.1e-20 70.6 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CDF40722.1 - 2.1e-18 65.6 0.5 6e-15 54.5 0.0 2.6 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r3 PF04539.16 CDF40722.1 - 1.3e-05 25.2 0.1 4.8e-05 23.4 0.1 2.0 1 1 0 1 1 1 1 Sigma-70 region 3 Sigma70_r1_2 PF00140.20 CDF40722.1 - 0.0093 16.0 0.1 0.055 13.5 0.0 2.3 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 Sigma70_r4_2 PF08281.12 CDF40722.1 - 0.061 13.0 0.3 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 Smg4_UPF3 PF03467.15 CDF40723.1 - 5.8e-28 98.1 0.5 1.7e-27 96.5 0.0 2.1 2 1 0 2 2 2 1 Smg-4/UPF3 family RRM_1 PF00076.22 CDF40723.1 - 0.022 14.5 0.0 0.43 10.4 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP_methylase PF00590.20 CDF40724.1 - 1e-21 77.9 0.1 1.9e-21 77.0 0.1 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases SET PF00856.28 CDF40725.1 - 3.9e-07 30.6 1.3 1.9e-05 25.1 0.0 3.4 2 2 0 2 2 2 1 SET domain preSET_CXC PF18264.1 CDF40725.1 - 0.0059 17.0 20.1 0.0059 17.0 20.1 3.4 3 1 0 3 3 3 1 CXC domain DTHCT PF08070.11 CDF40725.1 - 0.3 11.8 10.2 0.081 13.7 1.8 2.5 2 0 0 2 2 2 0 DTHCT (NUC029) region Lebercilin PF15619.6 CDF40726.1 - 0.0078 15.9 4.8 0.0078 15.9 4.8 10.5 2 2 5 9 9 9 2 Ciliary protein causing Leber congenital amaurosis disease RAB3GAP2_N PF14655.6 CDF40727.1 - 1.6e-14 54.0 0.1 2.6e-13 50.0 0.1 2.2 1 1 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus SET PF00856.28 CDF40728.1 - 2.2e-07 31.4 3.4 2.5e-06 28.0 0.1 2.9 2 2 0 2 2 2 1 SET domain Dynamitin PF04912.14 CDF40729.1 - 5.4e-21 75.4 4.0 6e-20 71.9 4.0 2.0 1 1 0 1 1 1 1 Dynamitin DOMON PF03351.17 CDF40731.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 DOMON domain SET PF00856.28 CDF40732.1 - 3e-12 47.2 0.3 1e-10 42.3 0.0 2.5 2 1 0 2 2 2 1 SET domain ANAPC2 PF08672.11 CDF40733.1 - 3e-19 69.3 0.9 8.1e-19 67.9 0.4 2.1 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 CDF40733.1 - 5.6e-19 68.2 0.1 1.6e-18 66.7 0.1 1.7 2 0 0 2 2 2 1 Cullin family HTH_27 PF13463.6 CDF40733.1 - 0.012 16.0 1.6 0.52 10.8 0.1 3.9 4 0 0 4 4 4 0 Winged helix DNA-binding domain HTH_20 PF12840.7 CDF40733.1 - 0.02 15.0 0.0 0.069 13.2 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 CDF40733.1 - 0.029 14.1 0.1 0.099 12.5 0.1 2.0 1 0 0 1 1 1 0 IclR helix-turn-helix domain SF3a60_bindingd PF12108.8 CDF40733.1 - 0.3 11.0 0.5 0.68 9.9 0.5 1.5 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain NDUF_B7 PF05676.13 CDF40734.1 - 7.2e-29 99.3 6.7 1.2e-28 98.6 6.7 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) 2-oxoacid_dh PF00198.23 CDF40735.1 - 3.8e-76 255.6 0.1 6.3e-76 254.9 0.1 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDF40735.1 - 5.2e-14 51.8 0.1 1.3e-13 50.5 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CDF40735.1 - 3.4e-12 46.5 0.5 6.5e-12 45.6 0.5 1.5 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CDF40735.1 - 0.0078 16.0 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like RuBisCo_chap_C PF18087.1 CDF40736.1 - 2.8e-12 46.5 0.1 4.4e-12 45.8 0.1 1.3 1 0 0 1 1 1 1 Rubisco Assembly chaperone C-terminal domain HRDC PF00570.23 CDF40736.1 - 0.071 13.1 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 HRDC domain Rad10 PF03834.14 CDF40739.1 - 2.2e-36 124.3 0.0 3e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 CDF40739.1 - 0.015 15.9 0.0 0.027 15.1 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.7 CDF40739.1 - 0.021 14.9 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif NAD_binding_6 PF08030.12 CDF40740.1 - 6.8e-10 39.3 0.0 1.2e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Lactamase_B_2 PF12706.7 CDF40745.1 - 0.0013 18.3 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF40745.1 - 0.0027 17.8 2.0 0.005 16.9 2.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Exostosin PF03016.15 CDF40746.1 - 4.1e-57 193.7 0.3 5e-57 193.4 0.3 1.1 1 0 0 1 1 1 1 Exostosin family Sec16_C PF12931.7 CDF40747.1 - 1.7e-27 96.9 0.0 2.6e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 CDF40747.1 - 0.00024 21.7 0.0 0.00092 19.8 0.0 2.1 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region ABC1 PF03109.16 CDF40749.1 - 4.4e-34 117.2 0.1 8.4e-34 116.3 0.1 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 CDF40749.1 - 0.00023 20.8 0.0 0.00087 18.9 0.0 2.0 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 CDF40749.1 - 0.00026 21.0 3.2 0.0059 16.5 0.2 3.8 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 CDF40749.1 - 0.02 14.2 0.0 0.046 13.1 0.0 1.6 1 1 0 1 1 1 0 Protein kinase domain zf-C3HC4_2 PF13923.6 CDF40750.1 - 1.8e-07 30.8 10.6 3.9e-07 29.8 10.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF40750.1 - 2.1e-07 30.7 11.1 3.8e-07 29.9 11.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF40750.1 - 6.3e-07 29.2 10.8 1.4e-06 28.1 10.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF40750.1 - 2.6e-06 27.4 8.9 7.1e-06 26.0 8.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDF40750.1 - 1.2e-05 25.2 8.9 2.6e-05 24.1 8.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDF40750.1 - 2.9e-05 24.1 9.3 6e-05 23.1 9.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CDF40750.1 - 3.1e-05 24.2 10.9 6.5e-05 23.2 10.9 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CDF40750.1 - 0.00035 20.4 14.7 0.0019 18.0 15.1 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 CDF40750.1 - 0.00099 19.2 0.0 0.0037 17.4 0.0 2.0 1 0 0 1 1 1 1 U-box domain zf-RING_6 PF14835.6 CDF40750.1 - 0.0024 17.7 4.4 0.0049 16.7 4.4 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 CDF40750.1 - 0.098 13.0 6.7 0.26 11.6 6.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 CDF40750.1 - 3.5 7.3 8.0 6 6.6 8.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Acetyltransf_1 PF00583.25 CDF40751.1 - 1e-05 25.8 0.0 1.8e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CDF40751.1 - 0.00083 19.4 0.0 0.0061 16.6 0.0 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDF40751.1 - 0.018 15.5 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF40751.1 - 0.031 14.2 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 CDF40751.1 - 0.15 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Glyco_transf_8 PF01501.20 CDF40752.1 - 2.4e-06 27.3 0.0 0.002 17.8 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Pkinase PF00069.25 CDF40756.1 - 7.4e-63 212.4 0.0 9.2e-63 212.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40756.1 - 5.4e-32 111.1 0.0 7.1e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF40756.1 - 3.6e-05 23.2 0.0 6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDF40756.1 - 8.6e-05 21.6 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF40756.1 - 0.004 17.1 2.2 0.03 14.2 0.1 2.7 2 1 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF40756.1 - 0.0048 16.2 0.0 0.13 11.5 0.0 2.3 1 1 0 2 2 2 1 Kinase-like Ribosomal_L36e PF01158.18 CDF40756.1 - 0.08 13.2 0.4 0.23 11.7 0.3 1.7 2 0 0 2 2 2 0 Ribosomal protein L36e PapB PF03333.13 CDF40756.1 - 0.17 12.0 0.0 43 4.2 0.0 3.0 3 0 0 3 3 3 0 Adhesin biosynthesis transcription regulatory protein Ribosomal_S21 PF01165.20 CDF40756.1 - 3.5 7.4 5.2 23 4.8 0.9 2.4 2 0 0 2 2 2 0 Ribosomal protein S21 Chorein_N PF12624.7 CDF40757.1 - 4.5e-19 68.7 0.0 1.6e-18 66.9 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Nnf1 PF03980.14 CDF40757.1 - 0.013 15.9 8.5 0.032 14.6 8.5 1.6 1 0 0 1 1 1 0 Nnf1 CENP-H PF05837.12 CDF40757.1 - 0.015 15.7 10.3 0.038 14.4 10.3 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) HOOK PF05622.12 CDF40757.1 - 0.018 13.3 11.1 0.027 12.7 11.1 1.1 1 0 0 1 1 1 0 HOOK protein GAS PF13851.6 CDF40757.1 - 0.019 14.3 9.1 0.045 13.1 9.1 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TMCO5 PF14992.6 CDF40757.1 - 0.1 12.2 9.4 0.21 11.1 9.4 1.4 1 0 0 1 1 1 0 TMCO5 family YabA PF06156.13 CDF40757.1 - 0.11 13.2 4.9 0.27 11.9 4.9 1.6 1 0 0 1 1 1 0 Initiation control protein YabA zf-C4H2 PF10146.9 CDF40757.1 - 0.25 11.6 4.9 0.65 10.3 4.9 1.7 1 0 0 1 1 1 0 Zinc finger-containing protein Fib_alpha PF08702.10 CDF40757.1 - 0.39 10.9 5.7 0.77 9.9 5.7 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family BRE1 PF08647.11 CDF40757.1 - 0.41 10.8 9.9 0.93 9.6 9.9 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF2203 PF09969.9 CDF40757.1 - 2.2 9.0 6.0 2.2 9.0 4.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) GBP_C PF02841.14 CDF40757.1 - 2.8 7.3 11.4 4.7 6.5 11.4 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF724 PF05266.14 CDF40757.1 - 3.1 7.6 10.0 7 6.4 10.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 CDF40757.1 - 3.5 5.4 5.5 5.2 4.9 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MIF4G_like_2 PF09090.11 CDF40757.1 - 6.1 6.2 7.8 26 4.2 0.0 2.4 1 1 1 2 2 2 0 MIF4G like Methyltransf_15 PF09445.10 CDF40759.1 - 7.5e-30 103.7 0.0 9.8e-30 103.3 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 CDF40759.1 - 1.2e-06 28.4 0.0 2.9e-06 27.2 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 CDF40759.1 - 3.2e-06 27.0 0.0 3.9e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 CDF40759.1 - 4.2e-06 26.6 0.0 7.4e-06 25.8 0.0 1.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 CDF40759.1 - 5.9e-06 26.0 0.0 8.3e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDF40759.1 - 7.4e-06 26.6 0.0 1.5e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF40759.1 - 0.0008 20.0 0.0 0.0025 18.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N PF00107.26 CDF40759.1 - 0.12 12.3 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DNA_methylase PF00145.17 CDF40759.1 - 0.19 11.0 0.1 0.72 9.1 0.0 1.8 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase Suf PF05843.14 CDF40761.1 - 5.3e-40 138.2 0.0 1.8e-32 113.5 0.0 3.3 2 1 0 2 2 2 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CDF40761.1 - 2.6e-06 27.8 18.1 0.017 15.9 0.0 8.4 8 2 4 12 12 12 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40761.1 - 0.00016 22.1 0.0 13 6.4 0.0 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40761.1 - 0.0003 21.2 3.5 0.92 10.3 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40761.1 - 0.0054 17.3 15.5 0.77 10.5 0.0 6.4 5 2 1 6 6 6 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CDF40761.1 - 0.0062 15.7 0.1 0.073 12.2 0.1 2.7 2 1 0 2 2 2 1 NRDE-2, necessary for RNA interference Orexin PF02072.15 CDF40761.1 - 0.1 12.5 0.1 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 Prepro-orexin TPR_9 PF13371.6 CDF40761.1 - 0.16 12.1 2.7 11 6.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PFK PF00365.20 CDF40762.1 - 9.5e-38 130.1 0.2 4.5e-37 127.9 0.1 2.0 2 1 1 3 3 3 1 Phosphofructokinase Pneumo_ncap PF03246.13 CDF40762.1 - 0.13 11.0 0.0 0.22 10.2 0.0 1.3 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein FAD_binding_1 PF00667.20 CDF40763.1 - 2.6e-28 99.1 0.0 4.2e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CDF40763.1 - 4.2e-23 82.1 0.0 8.3e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CDF40763.1 - 1.4e-19 70.7 0.0 3.5e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Clathrin_lg_ch PF01086.17 CDF40764.1 - 9.7e-20 71.6 0.3 1.3e-19 71.2 0.3 1.2 1 0 0 1 1 1 1 Clathrin light chain TPR_2 PF07719.17 CDF40765.1 - 5.2e-28 94.9 24.1 0.00054 19.9 0.2 10.7 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40765.1 - 3.7e-25 86.4 25.4 0.00085 19.9 1.9 9.8 3 2 7 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40765.1 - 1.3e-15 57.6 8.1 6.5e-05 23.4 0.1 5.9 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40765.1 - 2.3e-14 52.5 8.1 0.11 12.3 0.0 8.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF40765.1 - 2.7e-13 50.0 18.7 0.0021 18.3 0.2 7.9 5 2 2 7 7 7 5 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF40765.1 - 2.9e-11 43.4 16.0 0.056 13.4 0.1 8.1 6 3 1 8 8 8 3 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 CDF40765.1 - 3.6e-11 42.3 2.3 0.57 10.5 0.0 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40765.1 - 4.1e-09 36.9 25.7 0.0044 17.7 1.6 7.4 4 3 3 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDF40765.1 - 9.2e-07 28.3 17.3 0.75 8.9 0.6 5.9 1 1 5 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40765.1 - 9.3e-07 28.8 6.6 0.097 13.1 0.0 6.8 8 1 0 9 9 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDF40765.1 - 7.7e-06 25.5 0.0 0.29 10.8 0.1 4.9 4 1 1 5 5 5 1 TPR repeat TPR_7 PF13176.6 CDF40765.1 - 1e-05 25.2 3.3 2.9 8.1 0.1 6.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40765.1 - 0.00066 20.2 18.6 5.9 7.8 0.4 8.0 9 1 1 10 10 8 1 Tetratricopeptide repeat Suf PF05843.14 CDF40765.1 - 0.00076 19.5 11.5 0.96 9.4 0.6 4.9 2 2 3 5 5 5 2 Suppressor of forked protein (Suf) PPR PF01535.20 CDF40765.1 - 0.00077 19.5 3.1 0.37 11.1 0.0 5.7 8 0 0 8 8 6 1 PPR repeat TPR_9 PF13371.6 CDF40765.1 - 0.00094 19.3 4.1 10 6.4 0.0 5.1 3 2 1 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 CDF40765.1 - 0.00099 19.1 6.5 5.3 7.2 0.0 5.6 9 0 0 9 9 6 1 MIT (microtubule interacting and transport) domain HrpJ PF07201.11 CDF40765.1 - 0.0022 18.3 0.8 2.4 8.5 0.1 3.8 4 1 1 5 5 4 1 HrpJ-like domain DUF3887 PF13026.6 CDF40765.1 - 0.0081 16.9 1.7 73 4.3 0.1 4.5 3 1 1 4 4 4 0 Protein of unknown function (DUF3887) TPR_10 PF13374.6 CDF40765.1 - 0.0082 16.0 13.5 0.86 9.6 0.5 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat CesT PF05932.13 CDF40765.1 - 0.048 13.8 0.1 0.15 12.2 0.1 1.8 1 1 0 1 1 1 0 Tir chaperone protein (CesT) family DUF2015 PF09435.10 CDF40765.1 - 0.092 12.6 2.2 6.2 6.7 0.1 3.9 5 0 0 5 5 4 0 Fungal protein of unknown function (DUF2015) DUF2802 PF10975.8 CDF40765.1 - 0.14 12.3 2.0 38 4.5 0.0 4.5 5 0 0 5 5 4 0 Protein of unknown function (DUF2802) TPR_3 PF07720.12 CDF40765.1 - 0.63 10.1 8.7 39 4.4 0.1 5.5 7 0 0 7 7 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF40765.1 - 2.7 8.3 5.3 14 6.0 0.1 3.7 4 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 HAT PF02184.16 CDF40765.1 - 4.9 7.2 21.3 3.6 7.6 1.3 5.2 6 0 0 6 6 5 0 HAT (Half-A-TPR) repeat RabGAP-TBC PF00566.18 CDF40766.1 - 2.1e-09 37.4 0.3 2.9e-09 36.9 0.3 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Methyltransf_4 PF02390.17 CDF40766.1 - 0.007 15.8 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase UreE_C PF05194.12 CDF40766.1 - 0.09 13.3 0.5 0.25 11.9 0.1 1.9 2 1 0 2 2 2 0 UreE urease accessory protein, C-terminal domain NAC PF01849.18 CDF40767.1 - 4.4e-24 84.2 0.9 9.1e-23 80.0 0.5 2.3 2 0 0 2 2 2 1 NAC domain GNAT_like PF18407.1 CDF40767.1 - 0.097 13.0 1.3 0.28 11.6 1.3 1.8 1 0 0 1 1 1 0 GCN5-related N-acetyltransferase like domain MRG PF05712.13 CDF40768.1 - 5.7e-40 136.7 0.0 8.8e-40 136.1 0.0 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 CDF40768.1 - 1e-05 25.3 0.2 1.8e-05 24.5 0.2 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Tlr3_TMD PF17968.1 CDF40768.1 - 0.064 13.5 0.1 0.23 11.7 0.1 2.0 1 0 0 1 1 1 0 Toll-like receptor 3 trans-membrane domain Peptidase_M48 PF01435.18 CDF40769.1 - 2.7e-22 79.5 0.1 7.7e-22 78.0 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 CDF40769.1 - 0.00048 19.4 0.4 0.0018 17.6 0.1 1.8 2 0 0 2 2 2 1 BlaR1 peptidase M56 DUF1015 PF06245.11 CDF40771.1 - 7.6e-110 367.4 0.0 8.6e-110 367.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1015) Amino_oxidase PF01593.24 CDF40772.1 - 7.8e-37 127.6 0.0 1.1e-36 127.2 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDF40772.1 - 3.2e-14 52.9 0.4 9.7e-14 51.4 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDF40772.1 - 1.1e-08 35.1 5.2 0.00012 21.8 4.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDF40772.1 - 8.6e-06 25.2 0.2 8.1e-05 22.0 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDF40772.1 - 1.3e-05 24.5 0.7 3.9e-05 23.0 0.4 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CDF40772.1 - 2e-05 25.1 1.1 0.0037 17.8 1.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDF40772.1 - 6.4e-05 22.2 4.9 0.00011 21.5 4.9 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 CDF40772.1 - 0.0002 20.7 1.2 0.0003 20.1 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CDF40772.1 - 0.00023 20.0 1.8 0.00061 18.6 1.4 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CDF40772.1 - 0.00025 20.5 0.2 0.00038 19.9 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CDF40772.1 - 0.00046 19.4 2.3 0.00064 18.9 2.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CDF40772.1 - 0.001 18.4 1.2 0.061 12.6 1.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDF40772.1 - 0.0013 17.9 2.9 0.0032 16.6 1.2 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CDF40772.1 - 0.0053 16.1 1.1 0.0091 15.3 1.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain MCRA PF06100.11 CDF40772.1 - 0.14 10.9 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 MCRA family FMO-like PF00743.19 CDF40772.1 - 0.28 9.5 0.1 0.42 9.0 0.1 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like 3HCDH_N PF02737.18 CDF40772.1 - 0.29 11.0 2.5 0.26 11.2 1.2 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1499 PF07386.11 CDF40773.1 - 5.4e-32 110.8 0.1 1.7e-31 109.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1499) YqeY PF09424.10 CDF40773.1 - 1.1e-27 96.8 0.7 1.8e-27 96.1 0.7 1.3 1 0 0 1 1 1 1 Yqey-like protein ApbA_C PF08546.11 CDF40774.1 - 4.8e-26 91.4 0.3 7e-26 90.9 0.3 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CDF40774.1 - 4e-18 65.5 2.2 1.7e-17 63.4 2.2 1.9 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CDF40774.1 - 0.00049 20.6 1.4 0.0028 18.2 1.4 2.1 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 CDF40774.1 - 0.0025 17.7 1.1 0.0081 16.0 1.1 1.9 1 0 0 1 1 1 1 Rossmann-like domain DAO PF01266.24 CDF40774.1 - 0.026 14.1 2.5 0.15 11.6 2.5 2.1 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.23 CDF40774.1 - 0.03 14.3 0.1 0.057 13.4 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 CDF40774.1 - 0.052 13.1 0.2 0.093 12.3 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.6 CDF40774.1 - 0.072 13.3 0.3 0.19 12.0 0.3 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DnaJ-X PF14308.6 CDF40775.1 - 8.9e-29 100.4 5.2 3.8e-27 95.1 0.2 2.7 3 0 0 3 3 3 2 X-domain of DnaJ-containing DnaJ PF00226.31 CDF40775.1 - 6.1e-24 83.9 0.7 1.6e-23 82.6 0.7 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.28 CDF40775.1 - 5.8e-10 38.6 0.6 0.0085 15.9 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF40775.1 - 1.2e-08 34.4 6.8 0.0033 17.4 0.0 7.7 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40775.1 - 3.4e-05 24.3 8.8 0.51 11.3 0.0 6.5 5 2 1 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40775.1 - 0.00019 21.4 2.7 0.033 14.4 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF40775.1 - 0.00045 20.3 6.9 1.3 9.3 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40775.1 - 0.00088 19.5 0.0 14 6.4 0.0 4.6 3 0 0 3 3 3 1 Tetratricopeptide repeat T3SchapCesA PF11439.8 CDF40775.1 - 0.043 14.0 0.0 0.16 12.1 0.0 2.0 1 0 0 1 1 1 0 Type III secretion system filament chaperone CesA TPR_11 PF13414.6 CDF40775.1 - 0.077 12.7 6.6 4.5 7.0 0.0 5.2 8 1 1 9 9 9 0 TPR repeat TPR_19 PF14559.6 CDF40775.1 - 1.2 9.7 4.7 12 6.5 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 CDF40775.1 - 1.5 9.0 4.1 15 5.7 0.0 3.6 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DnaJ PF00226.31 CDF40777.1 - 1.3e-14 54.1 0.0 2.6e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain HEAT_2 PF13646.6 CDF40777.1 - 8e-08 32.6 3.9 0.00014 22.2 0.8 3.6 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 CDF40777.1 - 4.5e-07 29.9 13.7 0.078 13.7 3.2 5.2 5 0 0 5 5 5 3 PBS lyase HEAT-like repeat HEAT PF02985.22 CDF40777.1 - 0.0019 18.3 7.0 0.24 11.7 0.1 3.9 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 CDF40777.1 - 0.46 11.0 5.2 0.83 10.2 3.3 2.5 2 0 0 2 2 2 0 HEAT-like repeat DUF563 PF04577.14 CDF40778.1 - 3.2e-11 43.8 0.2 1.5e-10 41.6 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF563) Pkinase PF00069.25 CDF40779.1 - 1.1e-62 211.8 0.0 4.6e-61 206.5 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40779.1 - 5.7e-29 101.2 0.1 1.7e-19 70.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CDF40779.1 - 5.3e-05 23.3 0.7 0.0011 19.0 0.2 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDF40779.1 - 0.00021 20.7 0.0 0.00078 18.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDF40779.1 - 0.00029 20.3 0.2 0.00078 18.9 0.2 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDF40779.1 - 0.00068 18.5 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_C PF00433.24 CDF40779.1 - 0.00071 20.2 0.5 0.0027 18.4 0.5 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CDF40779.1 - 0.0048 15.9 0.0 0.0076 15.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CDF40779.1 - 0.14 11.8 0.1 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 GDC-P PF02347.16 CDF40780.1 - 7.7e-107 357.8 0.1 9.1e-107 357.5 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein PAP2 PF01569.21 CDF40783.1 - 0.025 14.3 0.2 0.085 12.6 0.2 2.0 1 1 0 1 1 1 0 PAP2 superfamily Pkinase_Tyr PF07714.17 CDF40784.1 - 5.2e-60 202.9 0.0 6e-60 202.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF40784.1 - 6.4e-53 179.8 0.0 7.7e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Transketolase_C PF02780.20 CDF40785.1 - 3.6e-24 85.0 0.0 5.1e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CDF40786.1 - 4.9e-20 71.9 0.0 6.7e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CDF40786.1 - 1.3e-13 50.8 2.0 2.2e-12 46.8 0.0 2.8 3 1 1 4 4 4 2 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDF40787.1 - 4.9e-20 71.9 0.0 6.7e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CDF40787.1 - 1.3e-13 50.8 2.0 2.2e-12 46.8 0.0 2.8 3 1 1 4 4 4 2 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 CDF40788.1 - 3.6e-24 85.0 0.0 5.1e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Ribosomal_L35Ae PF01247.18 CDF40789.1 - 5e-13 49.0 0.2 5.4e-13 48.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CDF40789.1 - 0.031 14.5 0.0 0.031 14.5 0.0 1.1 1 0 0 1 1 1 0 RimM N-terminal domain Ribosomal_L35Ae PF01247.18 CDF40790.1 - 0.00051 20.2 0.0 0.00059 19.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae Tox-HNH-HHH PF15637.6 CDF40791.1 - 0.028 14.6 0.1 0.06 13.5 0.1 1.5 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif ANAPC4_WD40 PF12894.7 CDF40792.1 - 0.00015 22.0 0.1 0.07 13.4 0.0 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40792.1 - 0.021 15.7 0.2 0.2 12.6 0.1 2.1 1 1 1 2 2 2 0 WD domain, G-beta repeat eIF2A PF08662.11 CDF40792.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 CDF40793.1 - 8.8e-09 35.5 6.3 0.11 12.8 0.2 6.4 4 3 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF40793.1 - 9.7e-08 31.9 17.4 4.3e-05 23.2 6.2 2.8 2 2 1 3 3 3 2 PQQ-like domain WD40 PF00400.32 CDF40793.1 - 3.6e-06 27.6 8.3 0.03 15.2 0.0 5.9 7 1 0 7 7 7 2 WD domain, G-beta repeat PQQ PF01011.21 CDF40793.1 - 2.2e-05 24.1 12.8 0.12 12.4 0.1 5.1 5 0 0 5 5 5 2 PQQ enzyme repeat PD40 PF07676.12 CDF40793.1 - 0.0066 16.4 13.0 13 5.8 0.0 7.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 CDF40793.1 - 0.053 13.4 0.4 71 3.3 0.0 4.0 4 0 0 4 4 4 0 Transcription factor IIIC subunit delta N-term Flavin_Reduct PF01613.18 CDF40794.1 - 1.7e-08 34.7 6.7 5.4e-05 23.3 0.2 2.4 2 1 1 3 3 3 2 Flavin reductase like domain CaKB PF03185.15 CDF40796.1 - 0.13 11.9 0.1 0.16 11.6 0.1 1.1 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Mito_carr PF00153.27 CDF40797.1 - 4.7e-63 209.2 3.5 8.3e-24 83.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PI3_PI4_kinase PF00454.27 CDF40799.1 - 1.8e-24 86.9 0.0 4.6e-24 85.6 0.0 1.6 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Guanylate_kin PF00625.21 CDF40800.1 - 6.8e-60 201.9 0.0 7.9e-60 201.6 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 CDF40800.1 - 1.4e-08 35.4 0.0 2.5e-08 34.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDF40800.1 - 9.1e-05 22.4 0.1 0.00022 21.2 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CDF40800.1 - 0.00047 20.6 0.4 0.001 19.5 0.4 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CDF40800.1 - 0.00098 19.4 0.2 0.083 13.1 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDF40800.1 - 0.0062 16.8 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDF40800.1 - 0.01 16.0 0.2 0.091 12.9 0.2 2.2 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDF40800.1 - 0.014 14.7 0.2 0.12 11.7 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.6 CDF40800.1 - 0.017 15.5 1.7 0.059 13.8 0.1 2.4 1 1 1 2 2 2 0 AAA domain NTPase_1 PF03266.15 CDF40800.1 - 0.019 14.9 0.2 0.043 13.7 0.2 1.8 1 1 0 1 1 1 0 NTPase dNK PF01712.19 CDF40800.1 - 0.032 14.1 0.2 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase MMR_HSR1 PF01926.23 CDF40800.1 - 0.073 13.1 0.0 0.12 12.5 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CDF40800.1 - 0.12 12.2 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PTS_IIB PF02302.17 CDF40800.1 - 0.12 13.1 0.5 11 6.7 0.0 2.8 1 1 2 3 3 3 0 PTS system, Lactose/Cellobiose specific IIB subunit S6PP PF05116.13 CDF40801.1 - 7.5e-13 48.6 0.0 9.3e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase MatE PF01554.18 CDF40802.1 - 4.6e-20 71.9 17.9 1.7e-13 50.5 12.7 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CDF40802.1 - 5.3e-07 29.8 1.8 5.3e-07 29.8 1.8 3.2 1 1 3 4 4 4 1 Polysaccharide biosynthesis C-terminal domain DUF2970 PF11174.8 CDF40802.1 - 0.067 13.1 4.9 5.5 6.9 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2970) DUF4079 PF13301.6 CDF40802.1 - 6 7.0 7.5 3.9 7.6 0.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) HEAT PF02985.22 CDF40804.1 - 7.7e-12 44.4 8.1 0.019 15.2 0.4 7.1 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.6 CDF40804.1 - 9.1e-09 35.6 7.3 0.084 13.3 0.0 5.0 3 2 1 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 CDF40804.1 - 3e-05 24.4 1.9 0.84 10.2 0.2 4.5 4 0 0 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 CDF40804.1 - 0.00025 21.1 0.5 0.13 12.3 0.0 3.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDF40804.1 - 0.0065 17.0 0.3 12 6.6 0.0 4.0 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 CDF40804.1 - 0.0079 14.8 1.9 0.1 11.1 0.9 2.8 2 1 0 2 2 2 1 Adaptin N terminal region CLASP_N PF12348.8 CDF40804.1 - 0.077 12.5 3.7 4.7 6.7 0.2 3.8 2 1 1 3 3 3 0 CLASP N terminal SAPIS-gp6 PF16722.5 CDF40804.1 - 0.26 11.7 2.0 0.61 10.5 2.0 1.6 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus DUF959 PF06121.14 CDF40804.1 - 6.5 7.0 10.6 1.4 9.2 6.6 1.8 1 1 1 2 2 2 0 Domain of Unknown Function (DUF959) Guanylate_cyc_2 PF09778.9 CDF40806.1 - 1.3e-08 34.4 0.0 1.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39 PF03412.15 CDF40806.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase C39 family Guanylate_cyc_2 PF09778.9 CDF40807.1 - 4.6e-18 65.3 0.0 5.2e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 Guanylylate cyclase IQ PF00612.27 CDF40808.1 - 0.14 12.0 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif HEAT_2 PF13646.6 CDF40810.1 - 5.5e-13 49.1 18.8 3.1e-06 27.5 0.9 6.2 6 1 1 7 7 7 5 HEAT repeats Cnd1 PF12717.7 CDF40810.1 - 4.7e-09 36.5 1.6 0.00045 20.3 0.1 3.6 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CDF40810.1 - 3.2e-08 33.1 20.3 0.24 11.8 0.0 8.1 9 0 0 9 9 9 4 HEAT repeat Adaptin_N PF01602.20 CDF40810.1 - 7.9e-07 28.0 2.4 0.0065 15.1 0.8 3.2 3 0 0 3 3 3 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 CDF40810.1 - 0.0092 16.1 0.3 6.2 7.0 0.0 3.4 3 0 0 3 3 3 1 V-ATPase subunit H Tti2 PF10521.9 CDF40810.1 - 0.021 14.4 0.1 0.16 11.5 0.0 2.5 2 1 1 3 3 3 0 Tti2 family HEAT_EZ PF13513.6 CDF40810.1 - 0.048 14.2 9.8 0.76 10.3 0.1 5.3 5 1 1 6 6 6 0 HEAT-like repeat BSD PF03909.17 CDF40811.1 - 3.8e-08 33.2 0.3 6.9e-08 32.4 0.3 1.5 1 0 0 1 1 1 1 BSD domain Acyltransferase PF01553.21 CDF40812.1 - 1.7e-12 47.1 0.0 2.7e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase SGS PF05002.15 CDF40813.1 - 8.5e-23 80.3 3.6 2.4e-22 78.8 3.6 1.8 1 0 0 1 1 1 1 SGS domain CS PF04969.16 CDF40813.1 - 5.7e-16 59.3 0.1 1.2e-15 58.3 0.1 1.6 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 CDF40813.1 - 7.7e-09 35.0 6.4 0.00012 21.9 0.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDF40813.1 - 1e-06 29.1 7.3 0.00012 22.5 1.4 4.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40813.1 - 7.3e-06 26.5 2.3 7.3e-06 26.5 2.3 2.3 4 0 0 4 4 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF40813.1 - 0.00015 21.7 5.4 0.0017 18.4 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDF40813.1 - 0.00045 19.9 6.1 0.016 15.0 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF40813.1 - 0.0025 18.3 2.3 0.011 16.2 0.1 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40813.1 - 0.0046 17.3 0.8 0.057 13.8 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3856 PF12968.7 CDF40813.1 - 0.45 10.6 6.5 0.47 10.5 1.2 3.0 2 2 1 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.6 CDF40813.1 - 3.2 8.6 7.1 2.6 8.9 0.1 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat MucB_RseB PF03888.14 CDF40814.1 - 0.096 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 MucB/RseB N-terminal domain Bromo_TP PF07524.13 CDF40817.1 - 0.071 13.1 0.0 0.093 12.8 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated HLH PF00010.26 CDF40818.1 - 0.00018 21.4 2.2 0.0014 18.6 0.4 2.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain CENP-F_leu_zip PF10473.9 CDF40818.1 - 0.0048 16.9 1.9 0.01 15.9 1.9 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 CDF40818.1 - 0.0095 14.4 0.6 0.018 13.5 0.6 1.4 1 0 0 1 1 1 1 Mitotic checkpoint protein APG6_N PF17675.1 CDF40818.1 - 0.01 16.3 1.0 0.01 16.3 1.0 1.6 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF2968 PF11180.8 CDF40818.1 - 0.013 15.1 1.6 0.035 13.7 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF4530 PF15039.6 CDF40818.1 - 0.039 14.1 0.0 0.095 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) CASP_C PF08172.12 CDF40818.1 - 0.077 12.3 0.3 0.077 12.3 0.3 2.1 3 0 0 3 3 3 0 CASP C terminal YabA PF06156.13 CDF40818.1 - 0.1 13.3 0.1 0.31 11.7 0.1 1.9 1 0 0 1 1 1 0 Initiation control protein YabA SF1-HH PF16275.5 CDF40818.1 - 0.12 12.7 6.4 0.16 12.4 4.7 2.1 1 1 1 2 2 2 0 Splicing factor 1 helix-hairpin domain Prominin PF05478.11 CDF40818.1 - 0.23 9.4 0.1 0.31 8.9 0.1 1.1 1 0 0 1 1 1 0 Prominin Fez1 PF06818.15 CDF40818.1 - 0.56 10.6 5.4 0.13 12.7 1.6 1.9 2 1 0 2 2 2 0 Fez1 ZapB PF06005.12 CDF40818.1 - 0.92 10.0 6.5 0.15 12.5 2.1 2.0 2 0 0 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 CDF40818.1 - 1.3 7.9 4.7 0.23 10.3 1.2 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein Cnn_1N PF07989.11 CDF40818.1 - 1.9 8.7 4.7 0.67 10.2 1.1 2.1 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 CDF40818.1 - 7.4 6.4 7.5 1.3 8.9 1.9 2.5 2 1 1 3 3 3 0 Septum formation initiator MFS_1 PF07690.16 CDF40819.1 - 1.8e-20 73.2 37.7 2.6e-20 72.7 37.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDF40819.1 - 0.00083 18.3 16.8 0.023 13.6 2.5 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter SPX PF03105.19 CDF40820.1 - 2.8e-25 90.0 9.1 2.1e-14 54.2 0.4 3.6 2 1 2 4 4 4 3 SPX domain DUF1995 PF09353.10 CDF40821.1 - 0.00026 21.1 2.3 0.00056 20.0 2.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1995) PucR PF07905.11 CDF40821.1 - 0.034 14.4 0.1 0.054 13.8 0.1 1.2 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family Mito_carr PF00153.27 CDF40822.1 - 2.9e-57 190.6 2.1 1.3e-22 79.5 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Glycos_transf_2 PF00535.26 CDF40823.1 - 1.6e-22 80.1 0.0 2.7e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDF40823.1 - 4e-11 43.3 0.3 6.8e-11 42.5 0.3 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 CDF40823.1 - 5.3e-05 23.2 0.0 0.0019 18.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDF40823.1 - 0.0054 16.4 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 CDF40823.1 - 0.03 15.0 0.0 0.43 11.3 0.0 2.3 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Pkinase PF00069.25 CDF40825.1 - 1.3e-64 218.1 0.0 6.1e-64 215.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40825.1 - 2.3e-31 109.0 0.0 3.9e-31 108.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF40825.1 - 2e-05 23.7 0.0 2.8e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF40825.1 - 0.037 14.0 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF40825.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Ribosomal_S17 PF00366.20 CDF40826.1 - 0.18 11.9 0.2 0.72 10.0 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S17 Inositol_P PF00459.25 CDF40827.1 - 1.2e-48 166.1 0.2 1.5e-48 165.7 0.2 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Inositol_P PF00459.25 CDF40828.1 - 3.6e-48 164.4 0.1 5e-48 164.0 0.1 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family CAP_N PF01213.19 CDF40829.1 - 1.8e-183 609.2 4.9 2e-44 152.4 0.1 5.1 1 1 4 5 5 5 5 Adenylate cyclase associated (CAP) N terminal BAAT_C PF08840.11 CDF40829.1 - 2.6e-07 30.8 6.1 0.27 11.1 0.1 3.8 4 0 0 4 4 4 3 BAAT / Acyl-CoA thioester hydrolase C terminal PNK3P PF08645.11 CDF40829.1 - 3.6e-05 23.5 0.5 9.9 5.8 0.0 4.4 4 0 0 4 4 4 1 Polynucleotide kinase 3 phosphatase PilJ PF13675.6 CDF40829.1 - 0.0033 17.5 1.2 2.7 8.1 0.0 4.6 5 0 0 5 5 5 1 Type IV pili methyl-accepting chemotaxis transducer N-term Closter_coat PF01785.17 CDF40829.1 - 0.0082 15.4 0.2 1.8 7.8 0.0 3.5 4 0 0 4 4 4 1 Closterovirus coat protein PEGA PF08308.11 CDF40829.1 - 0.15 12.0 0.3 0.31 11.0 0.3 1.5 1 0 0 1 1 1 0 PEGA domain REV1_C PF16727.5 CDF40829.1 - 0.3 11.5 4.8 14 6.2 0.1 4.1 4 0 0 4 4 4 0 DNA repair protein REV1 C-terminal domain DUF4872 PF16169.5 CDF40829.1 - 0.36 10.6 3.6 1.8 8.3 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4872) Shal-type PF11601.8 CDF40829.1 - 0.9 9.1 11.9 54 3.4 0.2 4.6 4 0 0 4 4 4 0 Shal-type voltage-gated potassium channels, N-terminal Ribosomal_L30_N PF08079.12 CDF40829.1 - 4.4 7.6 8.6 26 5.2 0.2 3.9 4 0 0 4 4 4 0 Ribosomal L30 N-terminal domain RT_RNaseH PF17917.1 CDF40830.1 - 2.8e-35 120.8 0.0 2.7e-34 117.6 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF40830.1 - 4.9e-34 116.4 0.0 9.6e-34 115.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF40830.1 - 3.2e-14 52.8 0.1 5.7e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDF40830.1 - 0.0012 19.0 0.0 0.0022 18.1 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Retrotran_gag_2 PF14223.6 CDF40831.1 - 1.1e-34 119.1 0.6 2e-34 118.2 0.6 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF40831.1 - 5.2e-22 78.3 0.1 1.8e-21 76.6 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF40831.1 - 9.4e-05 22.2 0.1 0.0003 20.6 0.1 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF40831.1 - 0.00054 19.7 0.0 0.0016 18.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Lactamase_B_2 PF12706.7 CDF40837.1 - 6.9e-19 68.2 0.2 2.5e-17 63.1 0.2 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDF40837.1 - 2.9e-08 34.0 0.0 5.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 CDF40837.1 - 0.0018 18.2 0.1 0.034 14.0 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain LCIB_C_CA PF18599.1 CDF40837.1 - 0.013 14.8 0.1 0.024 13.9 0.1 1.3 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Lactamase_B_6 PF16661.5 CDF40837.1 - 0.015 14.7 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain rve PF00665.26 CDF40838.1 - 8.1e-17 61.5 0.1 1.7e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF40838.1 - 1.7e-12 47.2 0.0 3.9e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF40838.1 - 8e-06 25.7 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF40838.1 - 0.0042 16.8 0.1 0.018 14.8 0.0 2.1 3 0 0 3 3 3 1 Integrase core domain zf-H2C2 PF09337.10 CDF40838.1 - 0.0096 16.1 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 CDF40838.1 - 0.013 15.6 0.0 0.032 14.4 0.0 1.6 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Pep_deformylase PF01327.21 CDF40839.1 - 1.5e-46 157.9 0.0 2e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Polypeptide deformylase RNase_II_C_S1 PF18614.1 CDF40839.1 - 0.07 13.1 0.3 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain Mago_nashi PF02792.14 CDF40841.1 - 0.059 13.5 0.2 0.092 12.9 0.2 1.3 1 0 0 1 1 1 0 Mago nashi protein DUF2198 PF09964.9 CDF40841.1 - 0.1 12.7 0.0 0.41 10.8 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) DUF4050 PF13259.6 CDF40842.1 - 0.0017 18.7 0.0 0.0029 17.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4050) Ras PF00071.22 CDF40843.1 - 1.2e-50 171.3 0.0 1.4e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDF40843.1 - 2.1e-31 108.6 0.0 2.8e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDF40843.1 - 6.1e-13 48.6 0.0 8.1e-13 48.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDF40843.1 - 3.9e-06 26.6 0.0 0.0047 16.5 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDF40843.1 - 1.3e-05 25.2 0.0 1.9e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDF40843.1 - 6.4e-05 22.4 0.0 8.4e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 CDF40843.1 - 0.0016 18.8 0.0 0.0036 17.7 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 CDF40843.1 - 0.0021 17.8 0.0 0.08 12.7 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 CDF40843.1 - 0.0054 16.7 0.0 0.0074 16.2 0.0 1.2 1 0 0 1 1 1 1 NTPase RsgA_GTPase PF03193.16 CDF40843.1 - 0.0055 16.6 0.0 0.031 14.2 0.0 1.9 2 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CDF40843.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDF40843.1 - 0.015 15.6 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CDF40843.1 - 0.016 14.9 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDF40843.1 - 0.075 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 CDF40843.1 - 0.087 12.2 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 CDF40843.1 - 0.087 13.2 0.0 0.29 11.5 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDF40843.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 CDF40843.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 CDF40843.1 - 0.17 12.3 0.0 0.22 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CDF40843.1 - 0.19 11.3 0.0 0.6 9.7 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 CDF40843.1 - 0.19 12.2 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Mo25 PF08569.11 CDF40844.1 - 1.1e-113 379.9 4.3 1.4e-113 379.6 4.3 1.0 1 0 0 1 1 1 1 Mo25-like DUF1186 PF06685.11 CDF40844.1 - 0.00016 21.1 0.3 0.5 9.7 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1186) PikAIV_N PF18605.1 CDF40844.1 - 0.038 13.6 0.0 0.094 12.3 0.0 1.7 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Trp_dioxygenase PF03301.13 CDF40846.1 - 1.5e-96 323.7 0.4 1.8e-96 323.5 0.4 1.0 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase SurA_N_2 PF13623.6 CDF40846.1 - 0.041 13.7 0.2 0.075 12.9 0.2 1.4 1 0 0 1 1 1 0 SurA N-terminal domain Colicin PF01024.19 CDF40846.1 - 0.091 12.7 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Colicin pore forming domain Tim17 PF02466.19 CDF40848.1 - 2.4e-29 101.9 6.4 4.1e-29 101.2 6.4 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family WD40 PF00400.32 CDF40849.1 - 6.1e-21 74.3 12.4 9.8e-08 32.6 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat DNase_NucA_NucB PF14040.6 CDF40849.1 - 0.12 12.7 0.4 0.23 11.8 0.4 1.4 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB 2-oxoacid_dh PF00198.23 CDF40850.1 - 2.9e-59 200.3 0.1 4.4e-59 199.8 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDF40850.1 - 1e-33 114.9 11.5 6.7e-18 64.3 0.7 3.2 3 0 0 3 3 3 2 Biotin-requiring enzyme E3_binding PF02817.17 CDF40850.1 - 1.4e-24 86.1 3.5 2.7e-11 43.6 0.1 2.7 2 0 0 2 2 2 2 e3 binding domain Biotin_lipoyl_2 PF13533.6 CDF40850.1 - 5.3e-05 23.0 0.0 0.36 10.7 0.0 4.0 2 1 1 3 3 3 1 Biotin-lipoyl like QRPTase_N PF02749.16 CDF40850.1 - 0.0023 17.9 0.9 1.9 8.6 0.0 4.2 5 0 0 5 5 5 1 Quinolinate phosphoribosyl transferase, N-terminal domain PYNP_C PF07831.13 CDF40850.1 - 0.017 14.8 0.2 0.78 9.4 0.0 3.4 3 0 0 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain GCV_H PF01597.19 CDF40850.1 - 0.019 14.9 0.8 4 7.3 0.1 2.9 2 0 0 2 2 2 0 Glycine cleavage H-protein HlyD_3 PF13437.6 CDF40850.1 - 0.051 14.3 1.1 2 9.1 0.1 3.5 2 2 0 2 2 2 0 HlyD family secretion protein CclA_1 PF16942.5 CDF40850.1 - 0.27 11.5 3.9 0.13 12.5 0.5 2.2 2 1 0 2 2 2 0 Putative cyclic bacteriocin ABC_membrane PF00664.23 CDF40851.1 - 1.9e-51 175.3 11.1 8e-33 114.3 2.9 3.1 2 1 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CDF40851.1 - 1.7e-41 141.9 0.0 7.6e-28 97.7 0.0 3.3 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 CDF40851.1 - 2e-08 34.0 1.7 0.00067 19.2 0.1 3.1 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CDF40851.1 - 0.089 13.0 0.2 17 5.7 0.0 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 CDF40851.1 - 0.1 12.7 0.0 0.47 10.6 0.1 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase Pkinase PF00069.25 CDF40852.1 - 4.6e-15 55.7 0.0 5.4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40852.1 - 6.4e-05 22.4 0.0 0.00013 21.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF40852.1 - 0.00043 19.7 0.0 0.00067 19.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF40852.1 - 0.0012 18.8 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDF40852.1 - 0.032 13.0 0.0 0.043 12.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CDF40852.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Methyltransf_11 PF08241.12 CDF40853.1 - 6.4e-11 42.8 0.0 9.2e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF40853.1 - 2.5e-08 33.9 0.0 3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF40853.1 - 4.7e-06 26.5 0.0 5.7e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF40853.1 - 1.3e-05 25.9 0.0 2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF40853.1 - 1.3e-05 25.8 0.0 2.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDF40853.1 - 0.0036 16.6 0.0 0.0041 16.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 CDF40853.1 - 0.042 12.8 0.0 0.055 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) SATase_N PF06426.14 CDF40857.1 - 1e-31 109.4 0.2 1.5e-31 108.9 0.2 1.3 1 0 0 1 1 1 1 Serine acetyltransferase, N-terminal Hexapep PF00132.24 CDF40857.1 - 1.6e-10 40.3 10.3 3.8e-08 32.8 2.8 2.8 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDF40857.1 - 0.0024 17.6 3.6 0.0024 17.6 3.6 2.6 2 1 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase Peptidase_M1 PF01433.20 CDF40858.1 - 3.8e-42 144.3 0.0 6.5e-42 143.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 CDF40858.1 - 3.3e-27 94.8 0.0 6.5e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 CDF40858.1 - 1e-16 61.7 0.0 1.7e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain START PF01852.19 CDF40859.1 - 0.0007 19.1 0.0 0.0019 17.7 0.0 1.7 1 1 0 1 1 1 1 START domain Bromodomain PF00439.25 CDF40860.1 - 4.8e-17 61.8 0.0 9.3e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 Bromodomain DNMT1-RFD PF12047.8 CDF40860.1 - 2.1e-09 37.6 0.0 1.4e-08 34.9 0.0 2.2 1 1 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain TMF_DNA_bd PF12329.8 CDF40860.1 - 0.24 11.4 2.0 0.44 10.6 0.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ubiquitin PF00240.23 CDF40862.1 - 4.7e-33 112.8 0.5 6.8e-33 112.2 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CDF40862.1 - 7.3e-28 96.2 9.6 1.2e-27 95.5 9.6 1.4 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CDF40862.1 - 8.8e-16 57.5 0.9 1.3e-15 57.0 0.9 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDF40862.1 - 2.9e-05 24.4 0.2 0.00011 22.6 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDF40862.1 - 0.006 16.5 0.1 0.0088 16.0 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CDF40862.1 - 0.0074 16.6 0.2 0.012 16.0 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 CDF40862.1 - 0.023 14.8 1.7 1.3 9.1 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDF40862.1 - 0.026 14.6 0.0 0.045 13.9 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CDF40862.1 - 0.04 14.5 0.1 0.049 14.2 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain MMR_HSR1 PF01926.23 CDF40864.1 - 7.8e-20 71.1 0.0 1.2e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDF40864.1 - 2e-08 34.0 0.0 2.9e-06 27.0 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CDF40864.1 - 3.4e-07 29.9 0.0 3.8e-06 26.5 0.0 2.1 1 1 1 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDF40864.1 - 5.9e-06 26.3 0.0 0.0061 16.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDF40864.1 - 0.00015 21.8 0.1 0.0036 17.4 0.1 2.3 1 1 1 2 2 2 1 Dynamin family AIG1 PF04548.16 CDF40864.1 - 0.0012 18.3 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 CDF40864.1 - 0.0021 18.2 0.0 0.0099 16.1 0.0 2.1 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CDF40864.1 - 0.0026 16.8 0.0 0.41 9.6 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 CDF40864.1 - 0.0041 17.4 0.2 0.44 10.8 0.0 2.8 1 1 2 3 3 3 1 AAA domain KH_1 PF00013.29 CDF40864.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 KH domain cobW PF02492.19 CDF40864.1 - 0.014 15.0 0.0 0.062 12.9 0.0 1.9 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TniB PF05621.11 CDF40864.1 - 0.021 14.2 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein KH_2 PF07650.17 CDF40864.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 KH domain AAA_9 PF12781.7 CDF40864.1 - 0.051 12.7 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 ATP-binding dynein motor region AAA_16 PF13191.6 CDF40864.1 - 0.068 13.5 0.2 0.14 12.6 0.2 1.5 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.22 CDF40864.1 - 0.13 11.8 0.0 1.3 8.6 0.0 2.1 1 1 0 1 1 1 0 Ras family UPF1_Zn_bind PF09416.10 CDF40866.1 - 5.8e-67 224.4 0.4 1.6e-66 223.0 0.1 1.8 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 CDF40866.1 - 3.6e-55 186.7 0.0 6e-55 186.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDF40866.1 - 5.3e-52 177.2 1.9 2e-28 99.9 0.1 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 CDF40866.1 - 5.6e-24 84.2 0.0 1.1e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 CDF40866.1 - 2.6e-15 56.6 0.0 8e-14 51.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF40866.1 - 1e-10 42.1 0.0 2.4e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CDF40866.1 - 1e-05 25.6 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CDF40866.1 - 2.8e-05 23.5 0.0 0.00021 20.6 0.0 2.3 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CDF40866.1 - 0.00018 21.4 0.0 0.00042 20.2 0.0 1.7 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 CDF40866.1 - 0.007 15.9 0.0 0.52 9.8 0.0 2.2 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 CDF40866.1 - 0.0081 15.9 0.2 0.77 9.5 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 CDF40866.1 - 0.0092 16.4 0.3 0.031 14.7 0.3 1.9 1 1 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 CDF40866.1 - 0.01 15.2 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 KaiC PIF1 PF05970.14 CDF40866.1 - 0.012 14.8 0.1 3.3 6.8 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_22 PF13401.6 CDF40866.1 - 0.015 15.5 0.3 0.045 14.0 0.1 1.9 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 CDF40866.1 - 0.021 14.3 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_10 PF12846.7 CDF40866.1 - 0.06 12.3 0.0 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain SRP54 PF00448.22 CDF40866.1 - 0.061 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA PF00004.29 CDF40866.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 CDF40866.1 - 0.14 11.9 0.2 0.25 11.1 0.2 1.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase RT_RNaseH PF17917.1 CDF40870.1 - 2.2e-36 124.3 0.1 3.1e-35 120.6 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF40870.1 - 1e-35 121.8 0.0 2.2e-35 120.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF40870.1 - 8.1e-07 29.1 0.5 1.9e-06 27.9 0.5 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF40870.1 - 0.03 13.9 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF40870.1 - 0.15 12.3 0.2 0.28 11.4 0.2 1.4 1 0 0 1 1 1 0 H2C2 zinc finger Pribosyltran_N PF13793.6 CDF40871.1 - 5.3e-49 165.0 0.2 1.8e-48 163.3 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDF40871.1 - 3.4e-23 82.6 1.9 1.2e-22 80.8 1.0 2.1 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDF40871.1 - 3.8e-22 78.5 3.3 2.5e-19 69.3 0.5 2.6 3 0 0 3 3 3 2 Phosphoribosyl transferase domain UPRTase PF14681.6 CDF40871.1 - 0.0009 18.7 0.3 0.0015 18.0 0.3 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DAO PF01266.24 CDF40872.1 - 0.0057 16.3 0.2 0.88 9.1 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Nup188 PF10487.9 CDF40873.1 - 0.0002 19.4 0.0 0.00068 17.7 0.0 1.8 1 1 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 LSM PF01423.22 CDF40875.1 - 9.5e-16 57.3 0.1 1.1e-15 57.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDF40875.1 - 0.0086 15.7 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Hfq protein Ku PF02735.16 CDF40877.1 - 6.5e-24 84.8 0.0 1.2e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 CDF40877.1 - 7.1e-12 45.5 0.1 1.4e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 Ku C terminal domain like baeRF_family3 PF18845.1 CDF40877.1 - 0.11 12.8 0.2 0.87 9.8 0.2 2.2 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 2OG-FeII_Oxy PF03171.20 CDF40878.1 - 5.5e-08 33.2 0.0 1.8e-07 31.6 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PLATZ PF04640.14 CDF40879.1 - 1.7e-19 70.2 0.4 1.7e-19 70.2 0.4 2.8 3 0 0 3 3 3 1 PLATZ transcription factor zf-B_box PF00643.24 CDF40879.1 - 0.026 14.7 8.1 0.026 14.7 8.1 1.9 2 0 0 2 2 2 0 B-box zinc finger zf-RING_10 PF16685.5 CDF40879.1 - 0.12 12.6 6.9 2 8.6 0.6 2.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 DUF2256 PF10013.9 CDF40879.1 - 0.85 9.8 8.1 8.8 6.5 0.1 3.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Ribosomal_L6 PF00347.23 CDF40881.1 - 1e-12 48.5 0.3 4.6e-12 46.5 0.1 2.1 3 0 0 3 3 3 1 Ribosomal protein L6 PPR_2 PF13041.6 CDF40882.1 - 7.1e-20 70.9 0.0 2.5e-05 24.4 0.0 7.5 7 2 2 9 9 9 3 PPR repeat family PPR PF01535.20 CDF40882.1 - 1.4e-16 59.5 0.0 0.0012 19.0 0.0 7.5 8 0 0 8 8 8 3 PPR repeat PPR_3 PF13812.6 CDF40882.1 - 1.4e-15 57.1 1.4 0.00019 21.5 0.0 6.7 5 2 1 7 7 7 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 CDF40882.1 - 1.2e-09 37.7 0.0 0.0023 17.6 0.0 4.8 5 0 0 5 5 5 2 PPR repeat PPR_long PF17177.4 CDF40882.1 - 9.7e-09 34.9 0.2 0.041 13.2 0.0 3.6 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP COX5A PF02284.16 CDF40882.1 - 0.0024 17.9 0.0 28 4.8 0.0 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Va TPR_14 PF13428.6 CDF40882.1 - 0.073 13.9 3.8 11 7.1 0.0 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat GST_C_3 PF14497.6 CDF40884.1 - 1.2e-09 38.3 0.0 1.9e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDF40884.1 - 1.3e-08 35.1 0.0 2.3e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDF40884.1 - 0.0028 18.0 0.0 0.0048 17.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDF40884.1 - 0.0063 16.8 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain TauE PF01925.19 CDF40885.1 - 1.9e-39 135.7 36.2 2.3e-39 135.4 36.2 1.1 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Tmemb_14 PF03647.13 CDF40885.1 - 0.11 13.3 0.3 0.11 13.3 0.3 3.2 2 1 1 3 3 3 0 Transmembrane proteins 14C RRM_1 PF00076.22 CDF40886.1 - 3.2e-05 23.7 0.0 6.5e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ub-RnfH PF03658.14 CDF40886.1 - 0.2 12.1 0.2 0.62 10.5 0.0 1.9 2 0 0 2 2 2 0 RnfH family Ubiquitin SAM_LFY PF01698.16 CDF40889.1 - 0.12 12.4 0.0 16 5.5 0.0 2.4 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain HTH_1 PF00126.27 CDF40890.1 - 6.3e-22 77.3 0.6 7e-22 77.1 0.6 1.0 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_IclR PF09339.10 CDF40890.1 - 0.0008 19.2 0.3 0.051 13.4 0.0 2.2 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_24 PF13412.6 CDF40890.1 - 0.0025 17.3 0.1 0.005 16.4 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_30 PF13556.6 CDF40890.1 - 0.0072 16.1 0.2 0.0094 15.7 0.2 1.1 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR_2 PF12802.7 CDF40890.1 - 0.0078 16.1 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 MarR family Phage_NinH PF06322.11 CDF40890.1 - 0.016 15.1 0.0 0.021 14.7 0.0 1.3 1 1 0 1 1 1 0 Phage NinH protein HU-CCDC81_euk_2 PF18289.1 CDF40890.1 - 0.079 13.1 0.0 0.088 13.0 0.0 1.1 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 IMS PF00817.20 CDF40893.1 - 4.8e-33 114.3 0.4 1.3e-32 112.9 0.1 1.8 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 CDF40893.1 - 3.5e-11 43.8 0.1 1.1e-10 42.2 0.1 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDF40893.1 - 4e-05 23.7 0.1 0.00014 22.0 0.1 1.9 1 0 0 1 1 1 1 IMS family HHH motif ABC2_membrane_5 PF13346.6 CDF40894.1 - 0.01 15.4 0.2 0.011 15.3 0.2 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Ninjurin PF04923.12 CDF40894.1 - 0.011 15.7 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 0 Ninjurin Sugar_tr PF00083.24 CDF40894.1 - 0.062 12.2 1.9 0.07 12.0 1.9 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter ADK PF00406.22 CDF40895.1 - 8.1e-44 149.4 0.0 9.7e-44 149.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 CDF40895.1 - 2.3e-15 56.3 0.0 4.1e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 CDF40895.1 - 1.6e-10 41.5 0.3 1.5e-09 38.4 0.0 2.0 1 1 1 2 2 2 1 AAA domain AGH PF17558.2 CDF40896.1 - 0.058 13.6 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 Androgenic gland hormone LRR_6 PF13516.6 CDF40898.1 - 0.0044 17.0 1.7 98 3.4 0.0 6.2 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 CDF40898.1 - 1.5 9.7 10.0 12 6.9 0.1 5.8 5 1 0 5 5 5 0 Leucine Rich Repeat RNase_H PF00075.24 CDF40899.1 - 0.016 15.4 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 RNase H Sel1 PF08238.12 CDF40900.1 - 1.7e-05 25.3 0.2 3.8e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 Sel1 repeat Bac_transf PF02397.16 CDF40901.1 - 3e-62 209.5 0.0 4.6e-62 208.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial sugar transferase CoA_binding_3 PF13727.6 CDF40901.1 - 1.1e-11 45.0 0.8 2.4e-11 43.9 0.8 1.6 1 0 0 1 1 1 1 CoA-binding domain PglD_N PF17836.1 CDF40901.1 - 0.00026 21.5 0.0 0.00055 20.5 0.0 1.5 1 0 0 1 1 1 1 PglD N-terminal domain MARVEL PF01284.23 CDF40901.1 - 1.3 9.0 9.4 2.7 8.0 9.4 1.4 1 0 0 1 1 1 0 Membrane-associating domain MerC PF03203.14 CDF40901.1 - 4.8 7.7 11.0 25 5.4 7.1 2.4 1 1 1 2 2 2 0 MerC mercury resistance protein PPR PF01535.20 CDF40902.1 - 2.4e-53 174.7 8.3 1e-05 25.5 0.0 12.1 11 1 0 11 11 11 9 PPR repeat PPR_2 PF13041.6 CDF40902.1 - 3.2e-51 171.3 7.3 4e-11 42.9 0.0 11.1 5 3 7 12 12 12 11 PPR repeat family PPR_1 PF12854.7 CDF40902.1 - 8e-45 150.2 2.3 6.9e-08 32.1 0.0 9.9 10 0 0 10 10 10 7 PPR repeat PPR_3 PF13812.6 CDF40902.1 - 1.3e-39 134.1 0.1 2e-12 47.0 0.0 7.9 4 3 5 9 9 9 8 Pentatricopeptide repeat domain PPR_long PF17177.4 CDF40902.1 - 1.1e-27 96.8 0.1 3.9e-10 39.5 0.0 4.2 2 2 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 CDF40902.1 - 2.1e-07 31.4 0.0 5.4 7.6 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat ATP13 PF12921.7 CDF40902.1 - 8.4e-05 22.4 0.9 0.03 14.2 0.2 3.8 3 1 1 4 4 4 1 Mitochondrial ATPase expression TPR_14 PF13428.6 CDF40902.1 - 0.00092 19.8 4.1 14 6.8 0.0 6.4 9 0 0 9 9 6 1 Tetratricopeptide repeat GMP_synt_C PF00958.22 CDF40902.1 - 0.019 15.0 0.0 2.1 8.5 0.0 3.0 3 0 0 3 3 3 0 GMP synthase C terminal domain EpuA PF11772.8 CDF40902.1 - 0.084 12.6 0.1 9 6.1 0.0 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta Coat_F PF07875.12 CDF40902.1 - 0.099 12.9 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 Coat F domain BTAD PF03704.17 CDF40902.1 - 0.49 10.8 2.4 24 5.3 0.0 4.0 6 0 0 6 6 5 0 Bacterial transcriptional activator domain Vps35 PF03635.17 CDF40903.1 - 4.3e-175 584.3 0.0 5.6e-175 583.9 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Herpes_UL69 PF05459.12 CDF40906.1 - 0.042 13.2 0.0 0.046 13.1 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family DX PF01666.17 CDF40907.1 - 0.02 15.3 17.6 0.18 12.3 2.4 3.4 2 1 1 3 3 3 0 DX module DX PF01666.17 CDF40909.1 - 0.015 15.7 62.8 0.28 11.7 2.3 7.5 4 3 3 7 7 7 0 DX module Haemocyan_bet_s PF14830.6 CDF40909.1 - 0.11 12.5 7.6 32 4.6 0.1 4.0 4 0 0 4 4 4 0 Haemocyanin beta-sandwich Lantibiotic_a PF14867.6 CDF40909.1 - 2.2 8.1 12.8 6.5 6.6 0.2 4.3 3 0 0 3 3 3 0 Lantibiotic alpha T2SSI PF02501.17 CDF40910.1 - 0.16 12.1 0.5 0.23 11.7 0.5 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I FOG_N PF15888.5 CDF40911.1 - 0.14 12.6 0.0 0.18 12.2 0.0 1.1 1 0 0 1 1 1 0 Folded gastrulation N-terminus Na_H_Exchanger PF00999.21 CDF40914.1 - 2.9e-44 151.4 42.8 4.4e-44 150.8 42.8 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4149 PF13664.6 CDF40914.1 - 0.1 13.0 0.1 0.1 13.0 0.1 3.6 4 1 1 5 5 5 0 Domain of unknown function (DUF4149) Mut7-C PF01927.16 CDF40915.1 - 7.1e-18 65.1 5.5 4.5e-17 62.5 4.7 2.2 1 1 0 1 1 1 1 Mut7-C RNAse domain Exo_endo_phos PF03372.23 CDF40915.1 - 0.00017 21.2 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5615 PF18480.1 CDF40915.1 - 0.013 15.3 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) PALP PF00291.25 CDF40917.1 - 2.4e-80 270.1 4.0 3.3e-80 269.6 4.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 CDF40917.1 - 3.4e-39 132.5 0.0 3.2e-19 68.5 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Lactamase_B_3 PF13483.6 CDF40917.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain SpoU_methylase PF00588.19 CDF40918.1 - 1.7e-29 102.8 0.0 2.4e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 CDF40918.1 - 1.1e-05 25.6 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Lactamase_B_2 PF12706.7 CDF40918.1 - 0.031 13.8 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain ApbE PF02424.15 CDF40920.1 - 7.6e-38 130.5 0.1 2.9e-37 128.6 0.0 2.0 2 0 0 2 2 2 1 ApbE family Flavin_Reduct PF01613.18 CDF40920.1 - 2.7e-08 34.0 1.4 2.7e-08 34.0 1.4 2.8 3 1 0 3 3 3 1 Flavin reductase like domain RT_RNaseH_2 PF17919.1 CDF40922.1 - 1.6e-31 108.3 0.0 4e-31 107.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF40922.1 - 2.2e-21 76.1 0.0 2.2e-20 72.9 0.0 2.7 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF40922.1 - 4.7e-20 72.0 0.0 1.1e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF40922.1 - 1.5e-15 57.0 0.1 3e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF40922.1 - 6.8e-10 38.7 0.0 1.3e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF40922.1 - 0.00021 21.0 0.3 0.0012 18.6 0.1 2.4 3 0 0 3 3 3 1 Integrase core domain zf-H2C2 PF09337.10 CDF40922.1 - 0.0073 16.5 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger DUF4118 PF13493.6 CDF40924.1 - 0.13 12.1 2.1 0.18 11.6 1.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4118) TAXi_C PF14541.6 CDF40925.1 - 4.5e-12 46.0 0.1 7.5e-07 29.1 0.0 2.2 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal Asp PF00026.23 CDF40925.1 - 7.4e-12 45.3 0.0 1.2e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CDF40925.1 - 0.084 13.5 0.0 0.18 12.5 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Oxidored_q2 PF00420.24 CDF40925.1 - 0.085 12.5 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GARS_A PF01071.19 CDF40926.1 - 6.1e-75 251.3 0.0 8.4e-75 250.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CDF40926.1 - 7.9e-30 103.5 0.1 2e-29 102.2 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 CDF40926.1 - 1.9e-25 88.9 1.6 4.8e-25 87.7 0.9 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp PF02222.22 CDF40926.1 - 0.00023 20.8 0.0 0.00038 20.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CDF40926.1 - 0.00069 19.2 0.2 0.0015 18.1 0.2 1.7 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 CDF40926.1 - 0.0027 17.8 0.0 0.0091 16.1 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CDF40926.1 - 0.0096 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 CDF40926.1 - 0.015 14.9 0.0 0.053 13.1 0.0 1.9 3 0 0 3 3 3 0 RimK-like ATP-grasp domain DegT_DnrJ_EryC1 PF01041.17 CDF40927.1 - 3.7e-55 187.7 0.0 4.2e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family IF2_N PF04760.15 CDF40930.1 - 0.052 13.4 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region T2SS-T3SS_pil_N PF13629.6 CDF40930.1 - 0.1 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Pilus formation protein N terminal region DUF3112 PF11309.8 CDF40931.1 - 0.036 13.5 0.1 0.048 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) DUF5308 PF17233.2 CDF40931.1 - 0.044 14.0 2.1 0.079 13.2 2.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) RNA_polI_A34 PF08208.11 CDF40931.1 - 0.15 12.1 9.0 0.26 11.3 9.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TPR_MLP1_2 PF07926.12 CDF40931.1 - 1.3 9.1 29.6 0.23 11.5 16.0 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Peptidase_S49_N PF08496.10 CDF40931.1 - 1.4 9.0 9.3 0.45 10.6 6.4 1.6 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Presenilin PF01080.17 CDF40931.1 - 3.2 6.4 5.1 4.4 6.0 5.1 1.3 1 0 0 1 1 1 0 Presenilin DHR10 PF18595.1 CDF40931.1 - 3.9 7.6 31.8 4.5 7.4 12.8 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4407 PF14362.6 CDF40931.1 - 3.9 6.7 19.3 6.2 6.1 19.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_S27e PF01667.17 CDF40932.1 - 9.1e-28 95.7 5.3 1.1e-27 95.4 5.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 FYVE_2 PF02318.16 CDF40932.1 - 0.031 14.5 0.7 0.035 14.3 0.7 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger TF_Zn_Ribbon PF08271.12 CDF40932.1 - 0.094 12.3 4.7 0.15 11.6 4.7 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding PP2C PF00481.21 CDF40932.1 - 0.14 11.7 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C VEFS-Box PF09733.9 CDF40934.1 - 7e-09 35.6 1.7 1.6e-08 34.5 0.0 2.3 3 0 0 3 3 3 1 VEFS-Box of polycomb protein zf-Di19 PF05605.12 CDF40934.1 - 0.023 15.0 2.1 0.059 13.7 2.1 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding ANAPC4_WD40 PF12894.7 CDF40935.1 - 3.2e-05 24.1 0.2 2.2 8.6 0.0 3.7 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDF40935.1 - 3.6e-05 24.5 5.6 12 6.9 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat WD40_like PF17005.5 CDF40935.1 - 0.00081 18.8 0.1 0.31 10.3 0.0 2.7 2 1 0 2 2 2 2 WD40-like domain PQQ_2 PF13360.6 CDF40935.1 - 0.0014 18.3 1.7 0.17 11.4 0.1 2.5 1 1 0 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 CDF40935.1 - 0.47 11.0 2.4 48 4.6 0.0 3.9 4 1 0 4 4 4 0 PQQ-like domain SNF5 PF04855.12 CDF40936.1 - 5e-44 150.9 0.9 5.8e-26 91.7 1.0 2.2 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 MerR_2 PF13591.6 CDF40936.1 - 0.019 14.8 0.1 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 MerR HTH family regulatory protein Dimer_Tnp_hAT PF05699.14 CDF40939.1 - 0.039 13.8 0.0 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region GTP_EFTU PF00009.27 CDF40941.1 - 6.1e-58 195.6 0.0 8.9e-58 195.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CDF40941.1 - 3.2e-21 75.2 0.0 5.6e-20 71.2 0.0 2.4 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_IV PF03764.18 CDF40941.1 - 5e-09 36.0 0.0 1.2e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 CDF40941.1 - 0.00037 20.6 0.0 0.00093 19.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CDF40941.1 - 0.016 15.6 0.0 0.062 13.7 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 2 RF3_C PF16658.5 CDF40941.1 - 0.076 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain CBS PF00571.28 CDF40942.1 - 2.3e-22 79.2 0.3 4.6e-05 23.8 0.0 4.4 4 0 0 4 4 4 4 CBS domain Thioredox_DsbH PF03190.15 CDF40943.1 - 0.0071 16.3 0.1 0.012 15.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Pkinase PF00069.25 CDF40944.1 - 9.6e-71 238.2 0.0 1.2e-70 238.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF40944.1 - 1.4e-39 136.0 0.0 1.9e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF40944.1 - 3.4e-07 29.8 0.2 5.7e-07 29.1 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF40944.1 - 5.8e-06 25.8 0.0 1.3e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDF40944.1 - 0.00032 19.8 0.1 0.00051 19.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF40944.1 - 0.022 14.7 0.3 0.11 12.3 0.0 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 CDF40944.1 - 0.029 14.0 0.3 0.064 12.9 0.3 1.4 1 1 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 CDF40944.1 - 0.14 10.9 0.0 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PAP2 PF01569.21 CDF40945.1 - 0.0015 18.3 0.7 0.014 15.2 0.7 2.1 1 1 0 1 1 1 1 PAP2 superfamily DDE_3 PF13358.6 CDF40946.1 - 5.4e-17 61.9 0.0 1.2e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.6 CDF40946.1 - 0.00018 21.2 1.4 0.00031 20.4 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDF40946.1 - 0.0011 19.2 2.0 0.0023 18.2 2.0 1.6 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_1 PF11427.8 CDF40946.1 - 0.0015 18.4 0.0 0.0036 17.1 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_Tnp_ISL3 PF13542.6 CDF40946.1 - 0.13 11.7 0.1 0.3 10.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 CDF40946.1 - 0.92 9.4 3.8 1.7 8.5 0.1 2.6 2 0 0 2 2 2 0 Homeodomain-like domain HTH_32 PF13565.6 CDF40946.1 - 1.4 9.6 6.3 4.3 8.0 1.3 3.1 2 1 1 3 3 3 0 Homeodomain-like domain HTH_28 PF13518.6 CDF40946.1 - 1.7 8.8 5.8 1.8 8.8 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain Sel1 PF08238.12 CDF40948.1 - 7.5e-15 55.0 0.2 3.6e-06 27.5 0.0 2.9 2 0 0 2 2 2 2 Sel1 repeat TPR_6 PF13174.6 CDF40948.1 - 6.7e-05 23.3 0.2 0.74 10.6 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat UbiD PF01977.16 CDF40948.1 - 0.01 14.7 0.7 2.9 6.7 0.1 2.2 2 0 0 2 2 2 0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase RXLR PF16810.5 CDF40948.1 - 0.02 15.3 0.0 12 6.3 0.0 2.6 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity MecA PF05389.12 CDF40948.1 - 0.022 14.4 0.3 4.8 6.8 0.1 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) MTA_R1 PF17226.2 CDF40948.1 - 0.062 13.4 0.0 24 5.2 0.0 2.6 2 0 0 2 2 2 0 MTA R1 domain YonK PF09642.10 CDF40948.1 - 0.15 12.2 0.2 33 4.7 0.0 2.7 3 0 0 3 3 3 0 YonK protein Sel1 PF08238.12 CDF40950.1 - 7.7e-117 379.1 23.8 3.8e-07 30.6 0.0 15.5 15 0 0 15 15 15 15 Sel1 repeat TPR_17 PF13431.6 CDF40950.1 - 7.1e-32 107.5 0.0 3.9 8.1 0.0 15.1 14 0 0 14 14 14 10 Tetratricopeptide repeat TPR_16 PF13432.6 CDF40950.1 - 8.8e-18 64.7 11.8 19 6.0 0.0 13.8 12 2 3 15 15 14 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF40950.1 - 2.2e-14 53.0 25.0 2.4 9.0 0.0 15.0 15 0 0 15 15 15 2 Tetratricopeptide repeat PPR_long PF17177.4 CDF40950.1 - 2.5e-14 53.2 9.3 28 4.0 0.0 13.7 15 0 0 15 15 15 0 Pentacotripeptide-repeat region of PRORP TPR_7 PF13176.6 CDF40950.1 - 4.4e-12 45.1 23.5 22 5.4 0.0 15.7 13 1 2 15 15 15 0 Tetratricopeptide repeat OpuAC PF04069.12 CDF40950.1 - 1.4e-06 28.1 0.1 5 6.6 0.0 5.7 1 1 3 4 4 4 2 Substrate binding domain of ABC-type glycine betaine transport system Ral PF11058.8 CDF40950.1 - 6.9e-06 25.5 19.1 47 3.7 0.0 10.7 11 1 1 12 12 12 0 Antirestriction protein Ral MotA_activ PF09114.10 CDF40950.1 - 8.7e-05 22.6 12.0 1.2e+02 2.9 0.0 9.4 1 1 8 10 10 10 0 Transcription factor MotA, activation domain Arg_decarb_HB PF17810.1 CDF40950.1 - 0.019 15.2 0.4 7.6 6.9 0.0 5.4 8 0 0 8 8 8 0 Arginine decarboxylase helical bundle domain HTH_Tnp_Tc3_1 PF11427.8 CDF40950.1 - 2.9 7.8 12.7 25 4.8 0.0 6.4 11 0 0 11 11 11 0 Tc3 transposase Keratin_B2 PF01500.17 CDF40953.1 - 1.1 9.2 8.8 0.52 10.3 6.5 1.5 2 0 0 2 2 2 0 Keratin, high sulfur B2 protein PerC PF06069.11 CDF40955.1 - 0.07 13.4 0.1 1.2 9.5 0.0 2.8 2 0 0 2 2 2 0 PerC transcriptional activator SIKE PF05769.11 CDF40957.1 - 0.088 12.7 0.3 0.14 12.1 0.3 1.3 1 0 0 1 1 1 0 SIKE family SNARE PF05739.19 CDF40957.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 SNARE domain Sel1 PF08238.12 CDF40958.1 - 1.6e-76 251.0 27.4 8.7e-07 29.4 0.0 11.6 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.6 CDF40958.1 - 2e-13 50.0 27.0 0.28 11.9 0.0 11.3 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF40958.1 - 2.3e-11 43.2 4.0 7.8 7.1 0.0 10.2 8 2 1 9 9 9 2 Tetratricopeptide repeat PPR_long PF17177.4 CDF40958.1 - 1.5e-08 34.3 13.3 0.31 10.4 0.0 8.8 6 4 3 10 10 10 2 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 CDF40958.1 - 3.9e-06 27.4 17.6 2.1 9.0 0.2 8.5 7 3 2 9 9 9 3 Tetratricopeptide repeat Arg_decarb_HB PF17810.1 CDF40958.1 - 0.00043 20.5 0.8 9.9 6.5 0.0 5.9 4 2 4 8 8 8 1 Arginine decarboxylase helical bundle domain TPR_14 PF13428.6 CDF40958.1 - 0.0012 19.5 21.8 23 6.2 0.0 10.5 9 3 3 12 12 12 0 Tetratricopeptide repeat OpuAC PF04069.12 CDF40958.1 - 0.068 12.7 0.0 12 5.4 0.0 3.8 1 1 3 4 4 4 0 Substrate binding domain of ABC-type glycine betaine transport system TAtT PF16811.5 CDF40958.1 - 0.33 10.2 17.5 1.6 8.0 0.1 7.6 5 2 6 11 11 11 0 TRAP transporter T-component DUF3311 PF11755.8 CDF40959.1 - 0.31 11.0 0.2 0.31 11.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) RF-1 PF00472.20 CDF40960.1 - 2 8.4 8.2 0.39 10.7 3.3 2.0 2 0 0 2 2 2 0 RF-1 domain Neur_chan_memb PF02932.16 CDF40960.1 - 6.8 6.7 7.2 3.6 7.6 5.1 1.5 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Patched PF02460.18 CDF40962.1 - 3.4e-27 94.9 28.2 7.8e-15 54.0 18.0 2.1 2 0 0 2 2 2 2 Patched family MMPL PF03176.15 CDF40962.1 - 6e-07 28.7 27.2 1.7e-06 27.2 5.7 2.3 2 0 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 CDF40962.1 - 9.1e-07 28.8 9.6 9.1e-07 28.8 9.6 2.8 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation DUF1856 PF08983.10 CDF40963.1 - 0.021 15.0 3.1 0.056 13.7 3.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1856) DEAD PF00270.29 CDF40965.1 - 3e-47 160.6 0.0 5.3e-47 159.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF40965.1 - 8e-20 71.2 0.0 2.1e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF40965.1 - 0.00018 21.6 0.0 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Glyco_transf_34 PF05637.12 CDF40966.1 - 9.4e-12 45.2 0.4 5.6e-07 29.5 0.0 2.9 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 CDF40966.1 - 0.00039 20.1 0.0 0.00055 19.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF273 Nucleotid_trans PF03407.16 CDF40966.1 - 0.0062 16.5 0.0 0.0097 15.9 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ATP12 PF07542.11 CDF40967.1 - 2e-33 115.2 0.0 3.7e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein PC_rep PF01851.22 CDF40968.1 - 4 8.1 4.7 3.1 8.4 0.9 2.7 3 0 0 3 3 3 0 Proteasome/cyclosome repeat PIF1 PF05970.14 CDF40969.1 - 3.9e-81 273.0 0.0 2.8e-66 224.2 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF40969.1 - 5.4e-59 199.6 0.1 1.1e-58 198.6 0.1 1.6 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40969.1 - 6.2e-06 26.1 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF40969.1 - 0.14 11.7 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF40969.1 - 0.18 9.7 0.0 0.27 9.1 0.0 1.1 1 0 0 1 1 1 0 Helicase PIF1 PF05970.14 CDF40970.1 - 5.7e-70 236.3 0.2 2.3e-52 178.4 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF40970.1 - 3.2e-60 203.6 0.0 5.4e-60 202.9 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF40970.1 - 1.8e-12 47.4 0.0 3.3e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF40970.1 - 0.018 15.4 0.0 0.044 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Herpes_Helicase PF02689.14 CDF40970.1 - 0.07 11.0 0.0 0.11 10.4 0.0 1.2 1 0 0 1 1 1 0 Helicase AMNp_N PF10423.9 CDF40970.1 - 0.12 12.0 0.0 0.32 10.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus UvrD_C_2 PF13538.6 CDF40970.1 - 0.14 12.0 0.0 0.64 9.9 0.0 2.1 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Integrase_H2C2 PF17921.1 CDF40971.1 - 1.1e-13 51.1 0.1 2.1e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 CDF40971.1 - 1.2e-12 48.0 0.1 2.8e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF40971.1 - 1.9e-11 44.2 0.0 2.1e-10 40.8 0.0 2.2 1 1 1 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDF40971.1 - 5e-05 23.4 0.0 0.00012 22.3 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 CDF40971.1 - 0.0027 17.7 0.0 0.0061 16.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Maf_N PF08383.11 CDF40971.1 - 2.9 7.7 5.1 1.6 8.6 0.6 2.8 3 0 0 3 3 3 0 Maf N-terminal region Ephrin_rec_like PF07699.13 CDF40974.1 - 3.3e-20 71.6 132.8 1.4e-08 34.3 5.4 16.1 7 6 10 17 17 17 11 Putative ephrin-receptor like NCD3G PF07562.14 CDF40974.1 - 7.8e-18 64.2 97.4 0.017 15.1 6.4 14.5 9 3 4 14 14 14 13 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDF40974.1 - 0.53 10.7 0.0 0.33 11.4 4.1 18.2 11 5 2 14 14 14 0 TNFR/NGFR cysteine-rich region Glyco_hydro_35 PF01301.19 CDF40977.1 - 2.9e-79 267.0 0.5 8.2e-79 265.5 0.5 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 CDF40977.1 - 0.071 12.4 1.4 0.64 9.3 0.8 2.2 2 0 0 2 2 2 0 Beta-galactosidase APAF1_C PF17908.1 CDF40981.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 APAF-1 helical domain WD40 PF00400.32 CDF40982.1 - 5.5e-54 178.9 35.2 2.3e-06 28.2 0.0 11.5 11 0 0 11 11 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF40982.1 - 7.6e-12 45.4 20.6 0.11 12.9 0.0 7.6 2 1 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF40982.1 - 7.7e-06 25.7 40.7 0.00031 20.4 8.3 4.0 1 1 2 3 3 3 3 PQQ-like domain BBS2_Mid PF14783.6 CDF40982.1 - 0.00088 19.3 0.1 15 5.6 0.0 5.1 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 CDF40982.1 - 0.024 14.0 0.0 2.3 7.5 0.0 3.5 5 0 0 5 5 5 0 WD40-like domain DUF727 PF05303.12 CDF40982.1 - 0.057 13.5 0.2 3.4 7.8 0.0 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF727) Nup160 PF11715.8 CDF40982.1 - 0.073 11.7 11.7 4.1 5.9 0.0 5.3 5 2 2 7 7 7 0 Nucleoporin Nup120/160 PQQ PF01011.21 CDF40982.1 - 0.15 12.1 12.3 11 6.1 0.1 5.7 7 0 0 7 7 7 0 PQQ enzyme repeat GTP_EFTU_D4 PF14578.6 CDF40982.1 - 0.35 10.8 6.3 29 4.6 0.0 5.9 4 1 1 6 6 6 0 Elongation factor Tu domain 4 DUF3313 PF11769.8 CDF40982.1 - 0.37 10.6 5.4 11 5.8 0.2 4.1 3 2 0 3 3 3 0 Protein of unknown function (DUF3313) Carb_anhydrase PF00194.21 CDF40983.1 - 1.5e-24 86.9 0.0 3.1e-24 85.9 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase MCM PF00493.23 CDF40985.1 - 9e-95 316.0 0.0 1.4e-94 315.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDF40985.1 - 5.1e-40 136.2 0.2 9.3e-40 135.4 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDF40985.1 - 8e-27 93.5 0.0 1.8e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDF40985.1 - 4.3e-10 40.1 0.0 1.5e-09 38.4 0.0 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CDF40985.1 - 1.3e-07 31.2 0.1 9.8e-06 25.1 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDF40985.1 - 3.4e-06 27.1 0.0 1.2e-05 25.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDF40985.1 - 0.0005 19.9 0.2 0.0069 16.2 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zn-ribbon_8 PF09723.10 CDF40985.1 - 0.066 13.3 1.4 0.15 12.2 1.4 1.6 1 0 0 1 1 1 0 Zinc ribbon domain Sigma54_activat PF00158.26 CDF40985.1 - 0.087 12.5 0.0 12 5.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 CDF40985.1 - 0.1 13.0 1.2 0.41 11.0 0.3 2.7 2 1 0 2 2 2 0 AAA ATPase domain Hydrolase_4 PF12146.8 CDF40987.1 - 5.5e-14 52.0 0.2 9.3e-05 21.8 0.0 3.3 3 0 0 3 3 3 3 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDF40987.1 - 8.3e-14 51.9 0.1 1.6e-05 24.7 0.0 3.3 3 0 0 3 3 3 3 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDF40987.1 - 1.6e-11 45.2 13.0 3.1e-09 37.8 7.8 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 CDF40987.1 - 2.1e-05 24.4 0.4 0.12 12.2 0.1 2.4 2 0 0 2 2 2 2 Serine hydrolase PGAP1 PF07819.13 CDF40987.1 - 0.00012 21.9 0.1 0.00034 20.4 0.0 1.8 2 0 0 2 2 2 1 PGAP1-like protein Esterase PF00756.20 CDF40987.1 - 0.003 17.3 0.0 0.0053 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 CDF40987.1 - 0.015 14.8 0.1 0.1 12.1 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Palm_thioest PF02089.15 CDF40987.1 - 0.05 13.4 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Palmitoyl protein thioesterase FSH1 PF03959.13 CDF40987.1 - 0.066 12.9 0.1 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Chlorophyllase2 PF12740.7 CDF40987.1 - 0.097 11.6 0.1 0.27 10.1 0.1 1.7 1 1 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S15 PF02129.18 CDF40987.1 - 0.1 12.2 0.5 0.28 10.7 0.3 1.7 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) LOR PF04525.12 CDF40988.1 - 3.5e-23 82.2 0.0 4.8e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 LURP-one-related WW PF00397.26 CDF40988.1 - 8.1e-08 32.2 5.7 3.1e-07 30.4 4.7 2.3 2 0 0 2 2 2 1 WW domain LRAT PF04970.13 CDF40989.1 - 1e-16 61.4 0.5 5.7e-16 59.0 0.5 1.9 1 1 0 1 1 1 1 Lecithin retinol acyltransferase An_peroxidase PF03098.15 CDF40991.1 - 5.7e-118 394.8 0.0 6.3e-118 394.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase RT_RNaseH_2 PF17919.1 CDF40992.1 - 1.1e-30 105.7 0.0 1.9e-30 104.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDF40992.1 - 1.7e-29 102.2 0.0 3.5e-29 101.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDF40992.1 - 4.9e-21 75.1 0.0 1.2e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDF40992.1 - 1.8e-15 56.8 0.1 4.4e-15 55.5 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CDF40992.1 - 3.1e-10 39.8 0.0 5.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CDF40992.1 - 7.5e-05 22.4 0.1 0.0003 20.5 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDF40992.1 - 0.00018 21.7 0.0 0.00039 20.6 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger baeRF_family11 PF18855.1 CDF40993.1 - 0.038 14.3 0.4 0.23 11.8 0.1 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 MCR_C PF04609.12 CDF40994.1 - 0.21 10.6 0.0 0.21 10.6 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C NB-ARC PF00931.22 CDF40995.1 - 1.1e-12 47.7 0.0 2.2e-12 46.7 0.0 1.4 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CDF40995.1 - 1e-08 35.5 0.0 2.4e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF40995.1 - 3e-06 27.1 0.0 5.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDF40995.1 - 4.1e-05 24.0 0.6 0.0001 22.8 0.6 1.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CDF40995.1 - 0.00082 19.3 0.0 0.0029 17.6 0.0 1.9 1 1 1 2 2 2 1 NACHT domain AAA PF00004.29 CDF40995.1 - 0.017 15.6 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDF40995.1 - 0.021 15.0 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 CDF40995.1 - 0.098 11.9 0.0 1.9 7.7 0.0 2.1 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA_19 PF13245.6 CDF40995.1 - 0.11 12.9 0.0 0.29 11.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain POR_N PF01855.19 CDF40999.1 - 0.088 12.5 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg DUF5480 PF17576.2 CDF41003.1 - 2.3 8.3 8.2 4.5 7.3 8.2 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5480) Helitron_like_N PF14214.6 CDF41005.1 - 2.5e-60 204.0 0.0 4.2e-60 203.2 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus zf-DNL PF05180.12 CDF41005.1 - 0.091 12.7 0.3 0.63 10.0 0.2 2.2 2 0 0 2 2 2 0 DNL zinc finger AMNp_N PF10423.9 CDF41005.1 - 0.091 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus rve PF00665.26 CDF41006.1 - 7.2e-22 77.8 0.0 1.4e-21 76.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF41006.1 - 0.0009 19.0 0.2 0.0027 17.5 0.1 1.9 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 CDF41006.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain PIF1 PF05970.14 CDF41007.1 - 8.8e-87 291.6 0.0 7.3e-72 242.5 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase Helitron_like_N PF14214.6 CDF41007.1 - 1.6e-49 168.7 0.1 4.6e-49 167.2 0.1 1.8 1 1 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF41007.1 - 4.2e-12 46.2 0.0 7.9e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CDF41007.1 - 0.018 13.0 0.0 0.029 12.3 0.0 1.2 1 0 0 1 1 1 0 Helicase AAA_19 PF13245.6 CDF41007.1 - 0.068 13.5 0.0 0.19 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.6 CDF41007.1 - 0.14 12.0 0.0 0.43 10.4 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Methyltransf_2 PF00891.18 CDF41008.1 - 4.3e-29 101.3 0.0 5.5e-29 101.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CDF41008.1 - 7.4e-15 54.7 0.0 2e-14 53.3 0.0 1.8 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_23 PF13489.6 CDF41008.1 - 4.8e-06 26.5 0.0 7.1e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF41008.1 - 7.9e-05 23.2 0.0 0.00014 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF41008.1 - 0.00013 22.7 0.0 0.00022 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF41008.1 - 0.00023 21.8 0.0 0.00047 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF41008.1 - 0.00031 20.3 0.0 0.00057 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Dimerisation PF08100.11 CDF41008.1 - 0.00042 20.3 0.2 0.00083 19.3 0.2 1.5 1 0 0 1 1 1 1 Dimerisation domain MarR PF01047.22 CDF41008.1 - 0.00044 20.1 0.0 0.0013 18.6 0.0 1.8 2 0 0 2 2 2 1 MarR family HTH_5 PF01022.20 CDF41008.1 - 0.00056 19.7 0.0 0.0054 16.6 0.0 2.4 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CDF41008.1 - 0.0014 18.5 0.1 0.0037 17.1 0.1 1.7 1 0 0 1 1 1 1 MarR family Methyltransf_31 PF13847.6 CDF41008.1 - 0.0027 17.5 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TrmB PF01978.19 CDF41008.1 - 0.0029 17.5 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 CDF41008.1 - 0.02 15.0 0.2 0.045 13.8 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DnaJ_CXXCXGXG PF00684.19 CDF41010.1 - 0.011 16.0 12.6 0.73 10.2 13.1 2.5 1 1 1 2 2 2 0 DnaJ central domain Sigma70_r2 PF04542.14 CDF41012.1 - 8e-09 35.1 0.0 1.8e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.16 CDF41012.1 - 1.7e-06 28.0 1.1 1e-05 25.5 0.1 2.3 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r4 PF04545.16 CDF41012.1 - 0.00098 18.6 3.9 0.0029 17.1 3.3 2.1 2 0 0 2 2 2 1 Sigma-70, region 4 Proteasome PF00227.26 CDF41013.1 - 1.7e-42 145.1 0.0 1.9e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Aldo_ket_red PF00248.21 CDF41015.1 - 2.9e-49 167.8 0.0 3.5e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family CpeT PF06206.11 CDF41015.1 - 0.026 14.5 0.0 0.039 13.9 0.0 1.2 1 0 0 1 1 1 0 CpeT/CpcT family (DUF1001) UPF0029 PF01205.19 CDF41016.1 - 7.4e-33 113.0 0.1 1.3e-32 112.3 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 CDF41016.1 - 1.9e-07 31.4 0.0 3.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 RWD domain DBD_Tnp_Mut PF03108.15 CDF41018.1 - 0.0073 16.3 0.3 0.011 15.8 0.3 1.3 1 0 0 1 1 1 1 MuDR family transposase zf-CCHC PF00098.23 CDF41020.1 - 0.0021 18.1 1.6 0.003 17.6 1.6 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 CDF41020.1 - 0.02 14.7 0.8 0.045 13.6 0.1 2.0 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 CDF41020.1 - 0.11 12.3 0.4 0.18 11.7 0.4 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDF41020.1 - 0.12 12.1 0.7 0.17 11.7 0.7 1.2 1 0 0 1 1 1 0 Zinc knuckle Glyco_tranf_2_4 PF13704.6 CDF41021.1 - 4.9e-12 46.2 0.0 1.2e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_92 PF01697.27 CDF41021.1 - 1.1e-10 41.6 0.1 2.2e-10 40.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 92 DEAD PF00270.29 CDF41023.1 - 6e-47 159.7 0.0 1.3e-46 158.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF41023.1 - 1.9e-27 95.8 0.0 7.5e-27 93.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDF41023.1 - 2.9 8.2 4.5 2.7 8.3 0.1 2.8 2 1 0 3 3 3 0 AAA domain Sel1 PF08238.12 CDF41025.1 - 2.4e-30 104.3 25.4 6.9e-05 23.4 0.0 11.9 12 1 0 12 12 12 7 Sel1 repeat TPR_16 PF13432.6 CDF41025.1 - 0.00025 21.6 0.1 0.00025 21.6 0.1 5.4 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDF41025.1 - 0.017 15.4 7.1 3.9 7.8 0.0 5.4 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDF41025.1 - 0.14 12.4 8.6 11 6.5 0.0 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDF41025.1 - 0.14 12.6 0.2 12 6.6 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF41025.1 - 0.21 12.3 10.9 28 5.6 0.0 6.8 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF41025.1 - 1.5 9.1 28.3 0.85 9.9 0.1 8.2 8 1 0 8 8 8 0 Tetratricopeptide repeat zf-RING_2 PF13639.6 CDF41027.1 - 2.7e-10 40.4 7.3 4.4e-10 39.7 7.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF41027.1 - 2.9e-08 33.9 7.8 7.5e-08 32.6 7.8 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDF41027.1 - 5.7e-08 32.7 2.3 9.9e-08 31.9 2.3 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDF41027.1 - 3.1e-07 30.1 7.5 5e-07 29.5 7.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF41027.1 - 3.2e-07 30.1 7.1 5.1e-07 29.5 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDF41027.1 - 1.2e-06 28.2 4.6 2e-06 27.6 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDF41027.1 - 4.5e-05 23.2 4.4 7.5e-05 22.5 4.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CDF41027.1 - 0.00023 21.0 6.5 0.00039 20.3 6.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 CDF41027.1 - 0.00086 19.0 2.5 0.0015 18.2 2.5 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 CDF41027.1 - 0.0052 16.8 3.4 0.013 15.5 3.4 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 CDF41027.1 - 0.0067 16.6 4.0 0.015 15.5 4.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 CDF41027.1 - 0.0083 15.7 4.0 0.016 14.8 4.0 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 CDF41027.1 - 0.011 15.8 0.8 0.026 14.7 0.8 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 CDF41027.1 - 7.8 6.7 8.1 18 5.6 8.1 1.6 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 CDF41027.1 - 9 6.7 6.5 16 5.9 6.5 1.4 1 0 0 1 1 1 0 RING-like domain DUF2076 PF09849.9 CDF41028.1 - 0.055 13.5 1.5 0.061 13.4 0.8 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PP2C PF00481.21 CDF41029.1 - 6.1e-37 127.6 0.1 1.2e-23 84.1 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDF41029.1 - 6.6e-08 32.4 0.1 4.5e-07 29.7 0.1 2.0 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 CDF41029.1 - 0.0005 20.1 0.3 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) HGTP_anticodon PF03129.20 CDF41030.1 - 8.9e-23 80.3 0.1 2.8e-22 78.7 0.1 1.9 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CDF41030.1 - 1.7e-09 37.9 0.0 1.3e-08 35.1 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Swi6_N PF18530.1 CDF41030.1 - 0.055 13.6 0.2 0.35 11.0 0.0 2.3 3 0 0 3 3 3 0 Swi6 N-terminal domain RRM_1 PF00076.22 CDF41032.1 - 0.00083 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Laminin_II PF06009.12 CDF41032.1 - 0.066 13.2 0.9 0.48 10.4 0.4 2.1 1 1 1 2 2 2 0 Laminin Domain II T7SS_ESX_EspC PF10824.8 CDF41032.1 - 1.1 9.8 4.6 5.6 7.5 0.2 2.6 1 1 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm Homeobox_KN PF05920.11 CDF41034.1 - 3.9e-16 58.6 0.8 8.3e-16 57.6 0.8 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 CDF41034.1 - 4e-05 23.4 2.0 9.2e-05 22.2 2.0 1.7 1 0 0 1 1 1 1 Homeodomain WD40 PF00400.32 CDF41035.1 - 5.9e-18 64.9 2.9 9.4e-06 26.3 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC5 PF12862.7 CDF41035.1 - 1.5e-15 57.0 0.4 1.5e-15 57.0 0.4 2.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 ANAPC4_WD40 PF12894.7 CDF41035.1 - 0.0005 20.3 0.0 3.5 8.0 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain RCC1 PF00415.18 CDF41037.1 - 7.2e-91 298.7 30.5 7.4e-17 61.7 0.3 8.0 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDF41037.1 - 2.6e-46 154.5 43.0 9.4e-12 44.4 0.4 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat DUF1459 PF07312.11 CDF41037.1 - 1.3 9.2 9.7 3.6 7.9 0.0 4.8 6 0 0 6 6 6 0 Protein of unknown function (DUF1459) DUF4213 PF13938.6 CDF41037.1 - 3 8.1 10.5 19 5.6 0.1 4.6 3 2 1 4 4 4 0 Putative heavy-metal chelation Skp1 PF01466.19 CDF41038.1 - 1.3e-08 34.8 0.1 3.7e-08 33.4 0.1 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain DUF1664 PF07889.12 CDF41038.1 - 0.11 12.6 0.4 0.21 11.6 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Colipase PF01114.18 CDF41042.1 - 0.071 12.8 2.3 0.09 12.5 2.3 1.3 1 0 0 1 1 1 0 Colipase, N-terminal domain SUI1 PF01253.22 CDF41043.1 - 8.7e-18 64.6 0.1 1.9e-17 63.5 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 EC042_2821 PF18740.1 CDF41043.1 - 0.097 12.5 0.2 9.2 6.1 0.1 2.3 2 0 0 2 2 2 0 EC042_2821-lke REase DinI PF06183.13 CDF41043.1 - 0.13 12.6 0.1 4.1 7.8 0.0 2.7 2 0 0 2 2 2 0 DinI-like family DUF167 PF02594.16 CDF41043.1 - 1.9 8.6 6.6 3.8 7.7 0.0 3.1 3 1 0 3 3 3 0 Uncharacterised ACR, YggU family COG1872 ThiC_Rad_SAM PF01964.18 CDF41045.1 - 3.7e-197 655.2 0.0 4.3e-197 655.0 0.0 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family ThiC-associated PF13667.6 CDF41045.1 - 1.6e-09 37.4 0.0 5.5e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 ThiC-associated domain Trypsin_2 PF13365.6 CDF41046.1 - 2.4e-29 103.2 1.5 4.8e-29 102.2 1.5 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDF41046.1 - 1.6e-12 47.7 0.0 2.4e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 CDF41046.1 - 2.7e-11 43.1 0.0 7.3e-11 41.7 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CDF41046.1 - 7e-08 32.7 0.2 2.4e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDF41046.1 - 2.4e-06 27.8 0.0 6.9e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Peptidase_S29 PF02907.15 CDF41046.1 - 0.019 14.7 0.2 0.043 13.6 0.2 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Tricorn_PDZ PF14685.6 CDF41046.1 - 0.026 14.5 0.1 0.06 13.3 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 CDF41046.1 - 0.12 11.0 0.2 1.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Peptidase S46 GCD14 PF08704.10 CDF41047.1 - 1.3e-68 231.3 0.0 2.2e-68 230.6 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 CDF41047.1 - 5.2e-06 26.4 0.0 1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CDF41047.1 - 0.00046 20.0 0.0 0.00099 18.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF41047.1 - 0.0074 16.9 0.1 0.025 15.2 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF41047.1 - 0.01 16.5 0.0 0.024 15.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain GCD14_N PF14801.6 CDF41047.1 - 0.017 14.9 0.0 0.047 13.5 0.0 1.7 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term STb_secrete PF09075.10 CDF41047.1 - 0.038 14.1 0.1 0.13 12.4 0.1 1.9 1 0 0 1 1 1 0 Heat-stable enterotoxin B, secretory Methyltransf_24 PF13578.6 CDF41047.1 - 0.088 13.8 0.0 0.19 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.25 CDF41048.1 - 6.3e-20 71.5 0.0 8.3e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDF41048.1 - 2.1e-11 43.8 0.1 2.7e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CDT1_C PF16679.5 CDF41048.1 - 0.063 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain tify PF06200.14 CDF41048.1 - 0.085 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 tify domain Pkinase PF00069.25 CDF41049.1 - 1.1e-27 97.1 0.0 1.7e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41049.1 - 1.8e-16 60.2 0.0 2.5e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF41049.1 - 0.0058 16.0 0.0 0.0096 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF41049.1 - 0.015 14.6 0.0 0.043 13.1 0.0 1.7 1 1 0 1 1 1 0 Kinase-like PDE8 PF08629.10 CDF41049.1 - 0.022 14.7 1.2 0.65 10.0 0.1 2.5 2 0 0 2 2 2 0 PDE8 phosphodiesterase Pkinase_fungal PF17667.1 CDF41049.1 - 0.13 11.0 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CLP_protease PF00574.23 CDF41050.1 - 1.9e-81 272.3 0.1 2.1e-81 272.2 0.1 1.0 1 0 0 1 1 1 1 Clp protease Chloroa_b-bind PF00504.21 CDF41051.1 - 4e-38 131.5 0.0 5.4e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein TFIIS_C PF01096.18 CDF41052.1 - 2.7e-19 68.7 7.4 2.7e-19 68.7 7.4 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 CDF41052.1 - 0.037 13.7 1.8 0.049 13.3 0.2 1.9 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain Glyco_transf_34 PF05637.12 CDF41055.1 - 6.5e-08 32.6 3.6 0.00039 20.2 0.2 3.2 2 1 1 3 3 3 3 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 CDF41055.1 - 0.035 14.1 0.1 0.061 13.3 0.1 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase DUF273 PF03314.14 CDF41055.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF273 Cwf_Cwc_15 PF04889.12 CDF41055.1 - 5.1 6.8 13.8 8.1 6.1 13.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Guanylate_kin PF00625.21 CDF41056.1 - 1.1e-49 168.5 0.0 1.5e-49 168.2 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 CDF41056.1 - 4e-06 27.1 0.0 1.3e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDF41056.1 - 0.0003 20.7 0.0 0.00059 19.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDF41056.1 - 0.00093 19.6 0.0 0.0024 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 CDF41056.1 - 0.0037 17.6 0.0 0.0067 16.8 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.6 CDF41056.1 - 0.0038 17.5 0.0 0.0071 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDF41056.1 - 0.0048 17.4 0.0 0.024 15.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDF41056.1 - 0.0067 16.5 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CDF41056.1 - 0.017 15.6 0.0 0.034 14.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 CDF41056.1 - 0.019 14.9 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 CDF41056.1 - 0.026 14.8 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDF41056.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 CDF41056.1 - 0.038 13.7 0.0 0.095 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 CDF41056.1 - 0.063 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 CDF41056.1 - 0.089 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 CDF41056.1 - 0.094 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 CDF41056.1 - 0.16 11.1 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 CDF41056.1 - 0.17 12.3 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDF41056.1 - 0.22 11.0 0.0 0.42 10.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region APG6_N PF17675.1 CDF41057.1 - 0.045 14.3 3.4 0.085 13.4 3.4 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Uso1_p115_C PF04871.13 CDF41057.1 - 0.48 10.8 6.3 0.89 9.9 6.3 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Nnf1 PF03980.14 CDF41057.1 - 0.64 10.4 9.1 0.21 12.0 4.9 2.3 2 0 0 2 2 2 0 Nnf1 YabA PF06156.13 CDF41057.1 - 1.2 9.8 5.0 0.41 11.3 1.9 1.7 2 0 0 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 CDF41057.1 - 1.4 9.4 6.6 2.3 8.7 5.4 2.0 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 CDF41057.1 - 4.6 7.1 7.5 37 4.2 7.5 2.2 1 1 0 1 1 1 0 Septum formation initiator Plant_tran PF04827.14 CDF41059.1 - 6.7e-79 264.2 0.0 9e-79 263.8 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF41059.1 - 1.2e-15 57.5 0.0 2.1e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_tranf_2_3 PF13641.6 CDF41059.1 - 0.074 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Pox_A_type_inc PF04508.12 CDF41062.1 - 3.1 7.8 5.6 0.62 10.0 0.1 2.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DNA_pol_A_exo1 PF01612.20 CDF41063.1 - 1.3e-20 73.8 0.0 2e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease DUF4811 PF16069.5 CDF41063.1 - 0.054 13.4 0.3 0.1 12.5 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) MFS_1 PF07690.16 CDF41065.1 - 3.2e-44 151.3 38.5 3.2e-44 151.3 38.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DnaJ_CXXCXGXG PF00684.19 CDF41065.1 - 0.064 13.6 1.5 0.12 12.8 1.5 1.4 1 0 0 1 1 1 0 DnaJ central domain ABC_tran PF00005.27 CDF41066.1 - 4.5e-18 66.1 0.1 5.3e-09 36.7 0.5 2.4 1 1 1 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDF41066.1 - 9.9e-07 28.9 0.0 0.0093 15.8 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDF41066.1 - 0.00028 20.6 0.2 0.0005 19.8 0.2 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CDF41066.1 - 0.001 18.6 0.1 0.076 12.4 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 CDF41066.1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_30 PF13604.6 CDF41066.1 - 0.049 13.3 0.1 0.079 12.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 CDF41066.1 - 0.049 13.7 1.3 0.15 12.2 1.3 1.7 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_15 PF13175.6 CDF41066.1 - 0.054 13.2 0.1 0.64 9.7 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDF41066.1 - 0.086 12.7 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase ABC_ATPase PF09818.9 CDF41066.1 - 0.087 11.6 0.1 0.85 8.3 0.1 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_22 PF13401.6 CDF41066.1 - 0.13 12.5 0.9 0.41 10.9 0.9 1.9 1 1 0 1 1 1 0 AAA domain SPT16 PF08644.11 CDF41067.1 - 4.6e-46 156.7 2.5 6.6e-46 156.2 0.0 2.4 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 CDF41067.1 - 6.7e-25 88.0 0.0 1.2e-24 87.2 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 CDF41067.1 - 4.3e-15 55.9 0.0 1.1e-14 54.6 0.0 1.7 1 0 0 1 1 1 1 Histone chaperone Rttp106-like FACT-Spt16_Nlob PF14826.6 CDF41067.1 - 4.3e-14 52.6 0.0 2.2e-13 50.3 0.0 2.2 1 1 1 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain DPBB_1 PF03330.18 CDF41071.1 - 3.6e-07 30.4 0.1 8.8e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 Lytic transglycolase HicA_toxin PF07927.12 CDF41074.1 - 0.084 12.9 0.0 0.089 12.8 0.0 1.2 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, EAF PF09816.9 CDF41075.1 - 2.1e-05 24.9 0.0 3.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor TFIIA PF03153.13 CDF41075.1 - 0.057 13.4 5.7 0.074 13.0 5.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 CDF41075.1 - 6.9 5.9 11.6 8.7 5.6 11.6 1.1 1 0 0 1 1 1 0 NOA36 protein GalKase_gal_bdg PF10509.9 CDF41076.1 - 2.4e-15 55.8 0.0 5.2e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 CDF41076.1 - 1.3e-12 47.9 0.0 1.4e-11 44.6 0.0 2.4 2 0 0 2 2 2 1 GHMP kinases C terminal PseudoU_synth_1 PF01416.20 CDF41076.1 - 4.7e-10 39.9 0.0 6.8e-09 36.2 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase GHMP_kinases_N PF00288.26 CDF41076.1 - 1.8e-07 31.3 1.0 4.2e-07 30.1 1.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain Cons_hypoth95 PF03602.15 CDF41077.1 - 5.8e-37 127.1 0.0 1.1e-36 126.2 0.0 1.4 2 0 0 2 2 2 1 Conserved hypothetical protein 95 RsmJ PF04378.13 CDF41077.1 - 0.00012 21.4 0.0 0.00018 20.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ MTS PF05175.14 CDF41077.1 - 0.0074 15.9 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain RP-C_C PF11800.8 CDF41077.1 - 0.098 12.7 0.7 0.14 12.2 0.1 1.5 2 0 0 2 2 2 0 Replication protein C C-terminal region N6_N4_Mtase PF01555.18 CDF41077.1 - 0.32 10.7 1.1 5.9 6.5 0.0 2.4 3 0 0 3 3 3 0 DNA methylase Trigger_N PF05697.13 CDF41078.1 - 2.2e-13 50.8 0.1 3e-13 50.3 0.1 1.2 1 0 0 1 1 1 1 Bacterial trigger factor protein (TF) TPR_2 PF07719.17 CDF41082.1 - 1.3e-13 49.9 0.3 0.00054 19.9 0.2 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 CDF41082.1 - 6.1e-13 48.9 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 CDF41082.1 - 6.1e-09 35.3 0.4 0.088 12.7 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDF41082.1 - 1.6e-06 28.3 0.3 0.81 10.0 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF41082.1 - 2.7e-06 27.5 0.2 1.1e-05 25.6 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDF41082.1 - 2.7e-06 26.9 1.8 0.099 12.3 0.1 3.5 2 1 1 3 3 3 3 TPR repeat TPR_9 PF13371.6 CDF41082.1 - 3e-05 24.1 0.2 9.7e-05 22.4 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDF41082.1 - 4.4e-05 23.5 0.0 0.041 13.9 0.0 2.7 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 CDF41082.1 - 0.00017 22.0 0.2 0.00086 19.8 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDF41082.1 - 0.00029 21.3 0.1 0.13 13.0 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDF41082.1 - 0.00032 20.5 1.7 1.2 9.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDF41082.1 - 0.00072 20.2 0.5 0.024 15.3 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDF41082.1 - 0.00089 19.3 0.2 0.96 9.8 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDF41082.1 - 0.00097 19.4 0.0 0.052 14.0 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDF41082.1 - 0.0055 17.4 0.9 0.069 14.0 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 CDF41082.1 - 0.0095 14.7 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) Glyco_transf_7C PF02709.14 CDF41083.1 - 1.2e-07 31.2 0.8 2.6e-07 30.2 0.2 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDF41083.1 - 8.1e-07 28.8 0.0 4.9e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 O-FucT PF10250.9 CDF41083.1 - 0.00012 21.9 0.0 0.0008 19.2 0.0 1.9 1 1 1 2 2 2 1 GDP-fucose protein O-fucosyltransferase NodZ PF05830.11 CDF41083.1 - 0.00096 18.0 0.2 0.028 13.2 0.0 2.7 3 0 0 3 3 3 1 Nodulation protein Z (NodZ) XG_FTase PF03254.13 CDF41083.1 - 0.0089 14.7 0.0 1.9 7.0 0.0 2.2 2 0 0 2 2 2 2 Xyloglucan fucosyltransferase Glycos_transf_2 PF00535.26 CDF41083.1 - 0.017 14.9 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Spo0M PF07070.11 CDF41083.1 - 0.078 12.5 0.0 2.4 7.6 0.0 2.2 1 1 1 2 2 2 0 SpoOM protein CDP-OH_P_transf PF01066.21 CDF41084.1 - 7.2e-13 49.1 0.4 7.2e-13 49.1 0.4 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase GAPES3 PF17154.4 CDF41085.1 - 0.036 14.0 0.1 0.054 13.5 0.1 1.2 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain Pkinase PF00069.25 CDF41086.1 - 2.8e-61 207.2 0.3 2.8e-61 207.2 0.3 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41086.1 - 8e-30 104.0 2.0 1.8e-22 79.9 0.8 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDF41086.1 - 0.00053 19.4 0.0 0.011 15.0 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDF41086.1 - 0.0047 15.9 0.7 0.0067 15.4 0.5 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF41086.1 - 0.0047 16.9 0.5 0.06 13.2 0.4 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 CDF41086.1 - 0.0067 16.1 0.8 1.9 8.0 0.2 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDF41086.1 - 0.0077 15.6 0.4 0.016 14.5 0.4 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDF41086.1 - 0.012 15.3 0.3 0.026 14.1 0.3 1.5 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 CDF41086.1 - 0.018 14.1 0.1 0.028 13.5 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 CDF41086.1 - 0.018 13.8 0.0 0.034 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Ax_dynein_light PF10211.9 CDF41086.1 - 0.037 14.0 1.9 0.07 13.1 1.9 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain zf-Nse PF11789.8 CDF41087.1 - 1.6e-09 37.4 0.0 3.3e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 CDF41087.1 - 0.011 15.4 1.2 0.014 15.1 0.0 1.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.6 CDF41087.1 - 0.012 15.6 0.1 0.073 13.1 0.0 2.1 2 0 0 2 2 2 0 RING-type zinc-finger DALR_1 PF05746.15 CDF41087.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 DALR anticodon binding domain zf-RAG1 PF10426.9 CDF41087.1 - 0.1 12.7 0.1 0.78 9.9 0.0 2.1 2 0 0 2 2 2 0 Recombination-activating protein 1 zinc-finger domain PAF-AH_p_II PF03403.13 CDF41087.1 - 0.18 10.3 0.0 0.26 9.8 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Aldose_epim PF01263.20 CDF41088.1 - 1e-19 71.0 0.0 1.2e-19 70.8 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Aldose_epim PF01263.20 CDF41089.1 - 2.3e-32 112.5 0.0 2.9e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase S6PP_C PF08472.10 CDF41091.1 - 0.0002 21.2 0.0 0.00027 20.8 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6-phosphate phosphohydrolase C-terminal DUF4440 PF14534.6 CDF41091.1 - 0.003 18.0 0.0 0.0039 17.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) V4R PF02830.18 CDF41091.1 - 0.18 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 V4R domain CBF PF03914.17 CDF41092.1 - 2.6e-26 92.7 0.0 6.4e-26 91.4 0.0 1.7 2 0 0 2 2 2 1 CBF/Mak21 family Nop53 PF07767.11 CDF41093.1 - 2e-24 86.8 17.5 2e-24 86.8 17.5 1.7 2 0 0 2 2 2 1 Nop53 (60S ribosomal biogenesis) DUF3614 PF12267.8 CDF41093.1 - 0.18 12.3 0.1 0.18 12.3 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3614) GTP_EFTU PF00009.27 CDF41094.1 - 4.5e-60 202.5 0.0 6.5e-60 202.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDF41094.1 - 2.4e-33 114.5 0.0 5.9e-33 113.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CDF41094.1 - 4.5e-31 106.8 0.0 9.8e-31 105.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDF41094.1 - 5.8e-22 77.5 0.1 1.3e-21 76.4 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDF41094.1 - 2.3e-15 56.7 0.0 6e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDF41094.1 - 4.7e-05 23.2 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDF41094.1 - 0.00093 19.3 0.1 0.002 18.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CDF41094.1 - 0.0014 18.0 0.0 0.0026 17.1 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Rad60-SLD PF11976.8 CDF41095.1 - 1.4e-14 53.7 0.0 3.1e-06 26.9 0.0 2.3 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDF41095.1 - 0.028 14.2 0.0 0.59 9.9 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin family PEMT PF04191.13 CDF41096.1 - 4.3e-13 49.6 0.0 6.3e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.14 CDF41096.1 - 7.9e-06 26.2 0.0 1.2e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ERG4_ERG24 PF01222.17 CDF41096.1 - 0.0024 16.7 0.0 0.0032 16.3 0.0 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family NnrU PF07298.11 CDF41096.1 - 0.008 15.7 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 NnrU protein LtrA PF06772.11 CDF41096.1 - 0.019 14.2 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) PsbL PF02419.17 CDF41096.1 - 0.019 15.0 0.2 0.064 13.3 0.1 1.9 2 0 0 2 2 2 0 PsbL protein Steroid_dh PF02544.16 CDF41096.1 - 0.19 11.7 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CDF41096.1 - 0.22 11.0 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Epimerase PF01370.21 CDF41100.1 - 2.2e-49 168.1 0.0 2.8e-49 167.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDF41100.1 - 4.4e-32 111.8 0.0 3.9e-31 108.7 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDF41100.1 - 2.4e-10 39.9 0.0 3.2e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CDF41100.1 - 5.2e-07 29.7 0.0 7.4e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CDF41100.1 - 3.6e-06 26.3 0.0 0.00024 20.3 0.0 2.3 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDF41100.1 - 6.9e-05 22.1 0.0 0.00012 21.3 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CDF41100.1 - 7.9e-05 22.2 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CDF41100.1 - 0.0017 17.6 0.0 0.28 10.3 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein adh_short_C2 PF13561.6 CDF41100.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase R3H-assoc PF13902.6 CDF41102.1 - 5.7e-07 30.0 1.3 8.3e-07 29.5 1.3 1.3 1 0 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.22 CDF41102.1 - 2.1e-05 24.4 1.8 3.1e-05 23.9 0.2 2.2 2 0 0 2 2 2 1 R3H domain AAA_11 PF13086.6 CDF41103.1 - 2e-55 188.4 6.0 4.2e-55 187.3 0.4 2.3 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CDF41103.1 - 2.3e-53 180.8 0.0 3.8e-53 180.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDF41103.1 - 1.4e-13 51.0 0.7 5.7e-12 45.8 0.7 2.4 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDF41103.1 - 5.8e-08 32.8 0.0 0.087 12.5 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CDF41103.1 - 5.9e-08 33.2 0.0 1.5e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain R3H PF01424.22 CDF41103.1 - 1.2e-07 31.6 1.3 2e-06 27.7 0.1 3.1 3 0 0 3 3 3 1 R3H domain Helicase_RecD PF05127.14 CDF41103.1 - 5.7e-06 26.3 0.2 0.00083 19.3 0.2 2.6 1 1 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 CDF41103.1 - 2.1e-05 24.2 0.0 4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 CDF41103.1 - 3.9e-05 23.5 0.1 0.0014 18.5 0.1 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_16 PF13191.6 CDF41103.1 - 0.00057 20.3 1.3 0.0018 18.7 0.6 2.3 2 0 0 2 2 1 1 AAA ATPase domain PhoH PF02562.16 CDF41103.1 - 0.00069 19.1 0.0 0.0032 16.9 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 CDF41103.1 - 0.0013 19.0 0.2 0.014 15.7 0.2 2.6 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CDF41103.1 - 0.0026 17.1 1.0 0.22 10.7 0.0 2.7 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CDF41103.1 - 0.003 17.2 1.7 0.024 14.2 1.7 2.3 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 CDF41103.1 - 0.0034 17.4 0.4 0.0087 16.0 0.0 1.9 2 0 0 2 2 1 1 Flavivirus DEAD domain IstB_IS21 PF01695.17 CDF41103.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.15 CDF41103.1 - 0.0097 15.9 0.0 0.059 13.4 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 CDF41103.1 - 0.03 13.4 0.0 0.058 12.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 CDF41103.1 - 0.048 14.1 0.1 0.27 11.6 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDF41103.1 - 0.089 12.5 0.0 0.5 10.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain ParA PF10609.9 CDF41103.1 - 0.09 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase UvrD_C_2 PF13538.6 CDF41103.1 - 0.1 12.4 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain 53-BP1_Tudor PF09038.10 CDF41103.1 - 0.14 12.1 0.2 0.97 9.4 0.0 2.4 3 0 0 3 3 2 0 Tumour suppressor p53-binding protein-1 Tudor DUF2203 PF09969.9 CDF41103.1 - 0.78 10.5 2.8 0.81 10.4 0.5 2.2 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2203) FAD_binding_7 PF03441.14 CDF41104.1 - 3e-50 170.5 0.0 4.7e-50 169.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CDF41104.1 - 4.6e-25 88.5 0.0 6.9e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 DNA photolyase Dor1 PF04124.12 CDF41105.1 - 6.8e-72 242.0 0.1 9.3e-72 241.5 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family FA_desaturase PF00487.24 CDF41106.1 - 4.2e-39 134.9 17.9 5.3e-39 134.6 17.9 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CDF41106.1 - 1.1e-18 67.2 0.0 2.3e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sugar_tr PF00083.24 CDF41107.1 - 3.1e-85 286.7 19.5 3.8e-85 286.4 19.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDF41107.1 - 3.2e-20 72.4 51.0 4.8e-17 61.9 24.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3021 PF11457.8 CDF41107.1 - 1.1 9.6 15.7 0.8 10.0 4.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) DUF2627 PF11118.8 CDF41107.1 - 7.3 7.2 7.5 4.9 7.8 2.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) HTH_Tnp_Tc5 PF03221.16 CDF41108.1 - 2.7e-09 36.9 0.0 6.7e-09 35.7 0.0 1.7 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 CDF41108.1 - 5.3e-06 26.0 0.0 0.021 14.5 0.0 2.5 2 0 0 2 2 2 2 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 CDF41108.1 - 0.00076 19.2 3.1 0.0013 18.5 0.2 2.7 3 1 0 3 3 3 1 Homeodomain-like domain HTH_7 PF02796.15 CDF41108.1 - 0.032 14.3 0.8 1.4 9.1 0.2 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_28 PF13518.6 CDF41108.1 - 0.042 14.0 0.8 0.11 12.6 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain SNF2_N PF00176.23 CDF41109.1 - 1.2e-58 198.5 0.1 6.5e-58 196.1 0.1 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF41109.1 - 3.2e-19 69.3 0.1 1.4e-18 67.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF41109.1 - 0.00055 20.0 0.0 0.0019 18.2 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Prok-RING_4 PF14447.6 CDF41109.1 - 0.17 11.7 12.8 0.4 10.6 12.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 LIM PF00412.22 CDF41110.1 - 9e-23 80.3 15.6 6.9e-12 45.4 5.1 2.4 2 0 0 2 2 2 2 LIM domain Ntox35 PF15534.6 CDF41110.1 - 0.096 13.1 0.0 0.36 11.3 0.0 2.0 1 0 0 1 1 1 0 Bacterial toxin 35 Rrn6 PF10214.9 CDF41110.1 - 1 7.8 13.3 1.4 7.3 13.3 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor RR_TM4-6 PF06459.12 CDF41110.1 - 4.4 7.0 8.6 6.8 6.4 8.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAP1 PF08601.10 CDF41110.1 - 10 5.8 18.9 19 4.8 18.9 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 PP2C PF00481.21 CDF41111.1 - 1.2e-58 198.8 0.1 1.5e-58 198.4 0.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.25 CDF41111.1 - 5.3e-40 137.5 0.0 7.8e-40 136.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41111.1 - 5.8e-36 124.1 0.0 2.7e-35 121.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF41111.1 - 6.7e-08 31.7 0.0 1.2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase PP2C_2 PF13672.6 CDF41111.1 - 1.2e-05 25.0 1.3 2.6e-05 24.0 1.3 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDF41111.1 - 0.068 13.1 0.1 5.9 6.7 0.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) RIO1 PF01163.22 CDF41111.1 - 0.14 11.7 0.1 0.23 11.0 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CDF41111.1 - 0.15 11.4 0.2 0.28 10.5 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family OST3_OST6 PF04756.13 CDF41113.1 - 2.4e-44 151.8 3.0 2.9e-44 151.6 3.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF4271 PF14093.6 CDF41113.1 - 0.00052 20.0 3.5 0.0006 19.8 1.1 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4271) Thioredoxin PF00085.20 CDF41113.1 - 0.0021 18.0 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin FGGY_N PF00370.21 CDF41114.1 - 3.7e-68 229.7 0.8 5.2e-68 229.2 0.8 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CDF41114.1 - 1.3e-45 155.6 2.2 2.1e-45 154.9 1.2 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain WD40 PF00400.32 CDF41115.1 - 2.1e-47 158.1 27.8 1.1e-08 35.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF41115.1 - 1.9e-08 34.5 2.4 1.4 9.2 0.0 5.1 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDF41115.1 - 0.0083 15.5 0.0 1 8.6 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 CDF41115.1 - 0.014 14.0 16.8 0.055 12.1 0.2 5.0 2 1 3 6 6 6 0 Nucleoporin Nup120/160 bMG3 PF11974.8 CDF41115.1 - 0.016 15.2 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain Cytochrom_D1 PF02239.16 CDF41115.1 - 0.025 13.1 0.1 1.2 7.6 0.2 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 CDF41115.1 - 0.056 13.4 0.1 31 4.7 0.1 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF325 PF03804.13 CDF41118.1 - 0.0015 18.5 0.0 0.002 18.1 0.0 1.2 1 0 0 1 1 1 1 Viral proteins of unknown function ADH_N PF08240.12 CDF41120.1 - 3.7e-23 81.5 0.4 1.1e-22 80.0 0.4 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CDF41120.1 - 1.1e-19 70.6 0.6 1.8e-19 70.0 0.6 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CDF41120.1 - 2e-09 37.3 1.4 3.8e-09 36.3 1.4 1.4 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CDF41120.1 - 0.00073 18.9 1.3 0.0013 18.1 1.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CDF41120.1 - 0.062 14.4 0.0 0.14 13.2 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Helitron_like_N PF14214.6 CDF41121.1 - 7.5e-35 120.9 0.1 1.2e-34 120.2 0.1 1.3 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus Herpes_Helicase PF02689.14 CDF41122.1 - 0.026 12.5 0.0 0.042 11.8 0.0 1.3 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF41122.1 - 0.09 12.6 0.5 0.51 10.2 0.1 2.6 2 1 0 2 2 2 0 UvrD-like helicase C-terminal domain DDE_3 PF13358.6 CDF41123.1 - 3.8e-12 46.2 0.1 7.8e-12 45.2 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 CDF41124.1 - 1.4e-06 28.1 0.1 2.6e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_32 PF13565.6 CDF41124.1 - 0.00011 22.8 1.6 0.15 12.7 0.1 3.1 2 1 1 3 3 3 2 Homeodomain-like domain HTH_38 PF13936.6 CDF41124.1 - 0.031 14.1 1.1 0.27 11.1 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain DMRL_synthase PF00885.19 CDF41125.1 - 9e-50 168.2 0.0 1e-49 168.0 0.0 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DUF5641 PF18701.1 CDF41125.1 - 0.16 12.2 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5641) DUF1731 PF08338.11 CDF41126.1 - 3.2e-18 65.3 2.0 3.6e-18 65.1 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 CDF41126.1 - 3.5e-16 59.4 0.2 2e-15 56.9 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDF41126.1 - 6.1e-07 29.2 1.0 0.00037 20.0 0.3 2.9 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDF41126.1 - 2.3e-05 23.7 0.1 0.071 12.2 0.1 3.2 3 0 0 3 3 3 2 RmlD substrate binding domain NAD_binding_10 PF13460.6 CDF41126.1 - 0.00014 21.8 1.6 0.00028 20.9 1.6 1.6 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_7 PF13241.6 CDF41126.1 - 0.0022 18.4 0.1 0.0049 17.3 0.1 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_4 PF07993.12 CDF41126.1 - 0.0039 16.4 0.2 0.017 14.3 0.1 2.1 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 CDF41126.1 - 0.015 14.4 0.2 2.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NmrA PF05368.13 CDF41126.1 - 0.039 13.5 0.2 0.06 12.9 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family KR PF08659.10 CDF41126.1 - 0.049 13.5 1.7 0.62 9.9 1.7 2.2 1 1 0 1 1 1 0 KR domain NAD_binding_2 PF03446.15 CDF41126.1 - 0.082 13.1 0.7 0.23 11.6 0.0 2.0 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3Beta_HSD PF01073.19 CDF41126.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.5 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDC-P PF02347.16 CDF41127.1 - 8.4e-90 301.6 0.1 9.4e-90 301.5 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein TFIIS_C PF01096.18 CDF41129.1 - 2.7e-19 68.7 7.4 2.7e-19 68.7 7.4 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 CDF41129.1 - 0.037 13.7 1.8 0.049 13.3 0.2 1.9 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain TIP41 PF04176.13 CDF41134.1 - 1.9e-47 161.0 0.0 2.6e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 TIP41-like family CLPTM1 PF05602.12 CDF41135.1 - 1.7e-112 376.6 0.0 2.2e-112 376.3 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 CDF41135.1 - 0.012 15.4 0.5 0.04 13.7 0.2 2.0 2 0 0 2 2 2 0 PQ loop repeat MMtag PF10159.9 CDF41135.1 - 0.56 10.5 3.2 0.73 10.2 0.1 2.7 3 0 0 3 3 3 0 Multiple myeloma tumor-associated SRP72 PF08492.12 CDF41139.1 - 9.4e-14 51.6 10.1 9.4e-14 51.6 10.1 2.6 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_14 PF13428.6 CDF41139.1 - 6.4e-07 29.7 20.5 0.013 16.3 0.0 7.6 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDF41139.1 - 1.9e-06 28.3 18.9 0.26 11.8 0.1 7.0 6 1 3 9 9 9 3 Tetratricopeptide repeat SRP_TPR_like PF17004.5 CDF41139.1 - 2.1e-05 24.5 0.2 0.048 13.7 0.0 3.5 4 0 0 4 4 4 1 Putative TPR-like repeat HrpB1_HrpK PF09613.10 CDF41139.1 - 0.0062 16.2 5.5 0.8 9.3 0.2 5.0 2 2 4 6 6 6 1 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.7 CDF41139.1 - 0.014 15.6 4.3 0.06 13.6 0.2 3.6 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 CDF41139.1 - 0.079 13.1 7.2 25 5.3 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF41139.1 - 0.088 13.5 0.0 0.088 13.5 0.0 6.4 6 1 2 8 8 8 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDF41139.1 - 1.2 10.0 26.4 1.6 9.6 0.5 7.4 7 1 1 8 8 8 0 Tetratricopeptide repeat YAcAr PF10686.9 CDF41139.1 - 1.8 8.6 4.6 30 4.7 1.5 3.2 3 0 0 3 3 3 0 YspA, cpYpsA-related SLOG family Methyltransf_16 PF10294.9 CDF41140.1 - 5.9e-16 58.7 0.0 8.8e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 CDF41140.1 - 1.1e-05 26.1 0.0 1.8e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF41140.1 - 0.00039 21.1 0.1 0.0009 19.9 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF41140.1 - 0.0015 18.3 0.1 0.0025 17.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF41140.1 - 0.0066 17.1 0.1 0.013 16.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF41140.1 - 0.0069 16.2 0.0 0.0095 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDF41140.1 - 0.013 14.9 0.1 0.019 14.4 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF1324 PF07038.11 CDF41140.1 - 0.027 14.7 0.4 1 9.7 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1324) MTS PF05175.14 CDF41140.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain HTH_Tnp_Tc3_1 PF11427.8 CDF41141.1 - 8e-09 35.2 0.1 1.6e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 Tc3 transposase HTH_38 PF13936.6 CDF41141.1 - 6.7e-06 25.8 0.1 2.1e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDF41141.1 - 0.00016 21.4 0.2 0.009 15.8 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CDF41141.1 - 0.0059 16.8 2.3 0.0062 16.8 1.0 1.8 2 1 0 2 2 2 1 Transposase Sigma70_r4_2 PF08281.12 CDF41141.1 - 0.01 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_28 PF13518.6 CDF41141.1 - 0.015 15.4 0.1 0.57 10.3 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1670 PF07900.11 CDF41141.1 - 0.06 12.7 0.1 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1670) Band_7 PF01145.25 CDF41142.1 - 5.5e-23 81.9 1.3 8.5e-23 81.3 1.3 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Hydrolase PF00702.26 CDF41142.1 - 0.019 15.3 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SRRM_C PF15230.6 CDF41142.1 - 0.022 15.3 0.2 0.038 14.5 0.2 1.4 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus Med2 PF11214.8 CDF41142.1 - 0.023 14.8 0.7 0.041 14.0 0.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 FKBP_C PF00254.28 CDF41143.1 - 8.2e-07 29.3 0.0 9.8e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Big_8 PF17961.1 CDF41143.1 - 0.11 12.7 0.0 0.14 12.3 0.0 1.4 1 1 0 1 1 1 0 Bacterial Ig domain HAD_2 PF13419.6 CDF41145.1 - 0.021 14.9 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RCC1 PF00415.18 CDF41147.1 - 2e-55 185.2 10.4 6.5e-10 39.5 0.1 8.3 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDF41147.1 - 7.5e-34 114.8 37.9 9.3e-08 31.7 0.7 8.1 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.25 CDF41148.1 - 1.3e-72 244.9 0.0 1.7e-72 244.5 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Methyltransf_23 PF13489.6 CDF41150.1 - 8.8e-15 54.9 0.1 2.4e-14 53.5 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF41150.1 - 3.2e-11 43.9 0.0 7.3e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF41150.1 - 1.3e-07 32.2 0.1 4.1e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF41150.1 - 2.8e-05 24.7 0.0 5.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF41150.1 - 0.0024 17.2 0.0 0.031 13.6 0.0 2.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MIF4G_like PF09088.11 CDF41151.1 - 1.1e-27 97.0 1.0 1.2e-25 90.4 0.1 2.4 1 1 1 2 2 2 2 MIF4G like MIF4G_like_2 PF09090.11 CDF41151.1 - 2e-20 73.4 0.1 4.6e-20 72.2 0.1 1.6 2 0 0 2 2 2 1 MIF4G like Fasciclin PF02469.22 CDF41152.1 - 1.5e-14 54.3 0.0 2.3e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain zf-4CXXC_R1 PF10497.9 CDF41153.1 - 0.00046 20.4 12.0 0.0011 19.1 12.0 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 iPGM_N PF06415.13 CDF41154.1 - 7.5e-58 195.5 0.4 1.5e-57 194.5 0.0 1.6 2 0 0 2 2 2 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 CDF41154.1 - 1.7e-56 191.4 0.0 1.9e-56 191.2 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 CDF41154.1 - 2.6e-05 24.0 0.0 0.00044 19.9 0.0 2.2 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase PIG-L PF02585.17 CDF41154.1 - 0.091 13.4 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase PglZ PF08665.12 CDF41154.1 - 0.13 12.3 0.1 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 PglZ domain Ribosomal_L31e PF01198.19 CDF41155.1 - 5.2e-41 138.8 1.3 6.4e-41 138.5 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e DUF3552 PF12072.8 CDF41156.1 - 2.6e-05 23.8 81.2 0.06 12.7 7.8 5.8 2 2 3 5 5 5 4 Domain of unknown function (DUF3552) Baculo_PEP_C PF04513.12 CDF41156.1 - 0.011 15.8 3.1 2.3 8.3 0.5 4.0 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Senescence PF06911.12 CDF41156.1 - 0.071 13.4 1.2 0.29 11.4 1.2 2.1 1 1 0 1 1 1 0 Senescence-associated protein NPV_P10 PF05531.12 CDF41156.1 - 0.55 10.7 8.9 23 5.5 0.1 5.4 5 1 0 5 5 5 0 Nucleopolyhedrovirus P10 protein Ly49 PF08391.10 CDF41156.1 - 7.9 6.9 7.4 1.2 9.6 0.2 2.8 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region Ribosomal_S2 PF00318.20 CDF41158.1 - 2.8e-29 101.9 0.0 1.4e-15 57.1 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 CDF41158.1 - 0.0015 19.8 19.9 0.0052 18.1 19.9 2.2 1 1 0 1 1 1 1 40S ribosomal protein SA C-terminus Topoisom_bac PF01131.20 CDF41158.1 - 0.16 10.9 0.0 0.21 10.6 0.0 1.1 1 0 0 1 1 1 0 DNA topoisomerase Pkinase_Tyr PF07714.17 CDF41159.1 - 3.8e-61 206.6 0.0 4.7e-61 206.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF41159.1 - 2.9e-53 180.9 0.0 3.7e-53 180.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF3299 PF11736.8 CDF41159.1 - 0.097 12.7 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) Glyco_hydro_47 PF01532.20 CDF41161.1 - 2.4e-117 392.7 0.0 2.8e-117 392.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SpoIIE PF07228.12 CDF41163.1 - 5.3e-09 36.3 0.0 8.1e-09 35.7 0.0 1.4 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CDF41163.1 - 6.8e-05 22.6 0.2 0.04 13.5 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDF41163.1 - 0.022 14.4 0.0 0.035 13.7 0.0 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C NTF2 PF02136.20 CDF41164.1 - 2.6e-31 108.7 0.0 2.9e-31 108.5 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 CDF41164.1 - 0.013 14.7 0.2 0.072 12.3 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) MFS_1 PF07690.16 CDF41165.1 - 4.2e-34 118.0 37.2 4.2e-34 118.0 37.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 CDF41165.1 - 0.67 8.7 14.2 0.011 14.6 2.9 2.6 2 1 0 2 2 2 0 LacY proton/sugar symporter DUF1427 PF07235.11 CDF41165.1 - 1.8 8.6 6.7 6 6.9 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1427) Alg6_Alg8 PF03155.15 CDF41166.1 - 9.3e-116 387.6 21.3 1.2e-115 387.3 21.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PS_Dcarbxylase PF02666.15 CDF41167.1 - 4.2e-43 147.2 0.0 5.2e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Peptidase_M23 PF01551.22 CDF41167.1 - 0.012 15.8 0.1 4.9 7.4 0.0 2.8 3 0 0 3 3 3 0 Peptidase family M23 PTS_EIIA_1 PF00358.20 CDF41167.1 - 0.02 14.6 0.0 8.6 6.1 0.0 2.3 2 0 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 TPR_2 PF07719.17 CDF41168.1 - 2.1e-22 77.3 24.2 2.8e-05 23.9 0.1 9.7 11 0 0 11 11 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDF41168.1 - 3.6e-19 67.7 12.2 0.0012 18.6 0.4 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDF41168.1 - 1.3e-17 62.4 5.3 0.00085 19.4 0.0 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF41168.1 - 6.3e-17 61.9 23.5 0.0034 18.0 0.1 7.8 6 2 2 8 8 7 5 Tetratricopeptide repeat ANAPC3 PF12895.7 CDF41168.1 - 9.5e-17 61.0 8.7 1.9e-11 44.0 0.0 5.7 5 1 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDF41168.1 - 4e-14 52.0 9.5 2.6e-06 27.0 0.5 7.0 6 2 2 8 8 8 3 TPR repeat TPR_19 PF14559.6 CDF41168.1 - 4.7e-14 52.6 20.2 0.0015 19.0 0.3 7.6 5 3 3 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDF41168.1 - 1.3e-13 50.3 6.2 0.55 10.7 0.0 8.7 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDF41168.1 - 8.9e-13 47.9 26.6 0.002 18.8 0.2 9.4 6 3 3 9 9 8 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDF41168.1 - 2.4e-12 46.0 3.0 0.016 15.2 0.0 7.5 7 2 1 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDF41168.1 - 1.4e-11 44.5 21.9 0.03 14.6 0.0 8.2 7 2 2 9 9 9 5 Tetratricopeptide repeat TPR_6 PF13174.6 CDF41168.1 - 3.2e-07 30.6 6.7 1.4 9.7 0.0 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDF41168.1 - 2.8e-05 24.2 6.4 0.52 10.5 0.3 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDF41168.1 - 0.00061 20.2 8.0 0.57 11.0 0.1 5.4 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDF41168.1 - 0.0014 17.9 7.3 1.7 7.8 0.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDF41168.1 - 0.002 17.9 7.5 3 7.8 0.1 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat Transcrip_act PF04949.13 CDF41168.1 - 0.33 10.8 1.8 1.2 9.0 0.8 2.2 2 0 0 2 2 2 0 Transcriptional activator SHNi-TPR PF10516.9 CDF41168.1 - 0.8 9.2 3.6 16 5.1 0.1 3.4 4 0 0 4 4 4 0 SHNi-TPR TPR_21 PF09976.9 CDF41168.1 - 2.5 7.8 8.6 1.8 8.2 0.5 3.8 3 2 1 4 4 4 0 Tetratricopeptide repeat-like domain WW PF00397.26 CDF41169.1 - 2.9e-37 126.4 32.9 4e-10 39.6 0.3 5.2 5 0 0 5 5 5 4 WW domain FF PF01846.19 CDF41169.1 - 2.1e-07 31.0 6.0 0.00011 22.3 0.1 4.3 4 0 0 4 4 4 2 FF domain Glyco_hyd_101C PF17451.2 CDF41169.1 - 0.0013 19.0 6.5 0.57 10.5 0.1 4.6 4 0 0 4 4 4 1 Glycosyl hydrolase 101 beta sandwich domain PQQ_2 PF13360.6 CDF41169.1 - 0.018 14.6 10.0 0.041 13.5 5.6 2.5 1 1 1 2 2 2 0 PQQ-like domain RhoGAP-FF1 PF16512.5 CDF41169.1 - 0.14 12.8 5.8 0.14 12.9 2.7 2.5 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain WW_1 PF18507.1 CDF41169.1 - 0.35 10.6 1.5 24 4.7 0.0 3.2 3 0 0 3 3 3 0 WW domain Ribosomal_S25 PF03297.15 CDF41170.1 - 1.9e-39 133.9 6.1 2.3e-39 133.6 6.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein PCI PF01399.27 CDF41170.1 - 0.022 15.2 0.0 0.023 15.2 0.0 1.1 1 0 0 1 1 1 0 PCI domain MarR_2 PF12802.7 CDF41170.1 - 0.055 13.4 0.1 0.11 12.4 0.0 1.5 2 0 0 2 2 2 0 MarR family ASXH PF13919.6 CDF41171.1 - 0.0029 17.6 0.0 0.0081 16.2 0.0 1.7 1 0 0 1 1 1 1 Asx homology domain MIR PF02815.19 CDF41172.1 - 2.8e-15 56.7 0.5 1.1e-09 38.4 0.2 2.8 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.11 CDF41172.1 - 0.00045 19.5 0.0 0.00077 18.7 0.0 1.3 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF3085 PF11284.8 CDF41173.1 - 0.087 13.1 0.0 0.61 10.4 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3085) ADH_N PF08240.12 CDF41174.1 - 3.6e-25 88.0 2.3 3.6e-25 88.0 2.3 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CDF41174.1 - 1.9e-24 86.1 0.1 3.2e-24 85.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDF41174.1 - 4.5e-06 27.7 0.0 7.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CDF41174.1 - 8e-06 25.5 0.0 2.5e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CDF41174.1 - 0.00021 20.7 0.5 0.0004 19.7 0.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Met_10 PF02475.16 CDF41174.1 - 0.0034 17.2 0.1 0.044 13.5 0.1 2.4 2 0 0 2 2 2 1 Met-10+ like-protein 2-Hacid_dh_C PF02826.19 CDF41174.1 - 0.19 11.1 0.1 0.32 10.3 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CLLAC PF15675.5 CDF41174.1 - 0.39 10.3 3.8 0.76 9.4 3.8 1.4 1 0 0 1 1 1 0 CLLAC-motif containing domain LIM PF00412.22 CDF41178.1 - 0.55 10.5 8.0 0.24 11.6 5.9 1.6 1 1 0 1 1 1 0 LIM domain AFG1_ATPase PF03969.16 CDF41181.1 - 1.4e-56 192.0 2.8 1.9e-52 178.4 0.5 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 CDF41181.1 - 0.00012 22.5 0.3 0.005 17.3 0.0 2.8 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDF41181.1 - 0.01 16.1 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 CDF41181.1 - 0.034 14.0 0.1 3.5 7.4 0.0 2.6 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_5 PF07728.14 CDF41181.1 - 0.045 13.7 0.0 0.68 9.9 0.0 2.9 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CDF41181.1 - 0.073 13.5 0.0 0.18 12.2 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 CDF41181.1 - 0.14 11.2 0.0 13 4.8 0.0 2.2 2 0 0 2 2 2 0 MCM P-loop domain Inositol_P PF00459.25 CDF41184.1 - 3.3e-52 177.7 0.3 6.3e-52 176.8 0.3 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family DUF1732 PF08340.11 CDF41184.1 - 5.2e-29 100.1 0.3 1.3e-28 98.8 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1732) YicC_N PF03755.13 CDF41184.1 - 4.4e-27 95.4 0.0 1e-26 94.2 0.0 1.6 1 0 0 1 1 1 1 YicC-like family, N-terminal region BshC PF10079.9 CDF41184.1 - 0.0048 15.7 0.4 0.0071 15.1 0.4 1.1 1 0 0 1 1 1 1 Bacillithiol biosynthesis BshC GvpL_GvpF PF06386.11 CDF41184.1 - 8.7 6.2 8.9 70 3.2 0.0 2.7 1 1 2 3 3 3 0 Gas vesicle synthesis protein GvpL/GvpF Reticulon PF02453.17 CDF41185.1 - 2.3e-26 92.6 0.1 2.9e-26 92.3 0.1 1.1 1 0 0 1 1 1 1 Reticulon PRT_C PF08372.10 CDF41185.1 - 0.0018 18.0 0.5 0.0059 16.4 0.2 1.8 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 CDF41185.1 - 0.067 12.6 0.1 0.74 9.2 0.1 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) DUF4064 PF13273.6 CDF41185.1 - 0.64 10.3 6.8 5.5 7.3 4.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) IMPDH PF00478.25 CDF41186.1 - 6.4e-133 443.0 0.4 7.4e-133 442.8 0.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CDF41186.1 - 6.5e-13 48.9 0.0 1.6e-05 25.3 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 CDF41186.1 - 2.4e-08 33.8 0.4 1.7e-05 24.4 0.1 2.4 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 CDF41186.1 - 4.4e-07 29.2 0.1 1.3e-06 27.7 0.2 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CDF41186.1 - 0.00067 19.2 0.3 0.0057 16.1 0.1 2.2 1 1 1 2 2 2 1 Histidine biosynthesis protein DHO_dh PF01180.21 CDF41186.1 - 0.00099 18.4 0.8 0.0023 17.2 0.3 1.8 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase DUF561 PF04481.12 CDF41186.1 - 0.0023 17.2 0.6 0.84 8.8 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF561) ThiG PF05690.14 CDF41186.1 - 0.0036 16.6 0.2 0.0073 15.6 0.2 1.6 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG Aldolase PF01081.19 CDF41186.1 - 0.052 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 KDPG and KHG aldolase Dus PF01207.17 CDF41186.1 - 0.13 11.3 0.2 5.8 5.9 0.0 2.2 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) Glyco_hydro_38N PF01074.22 CDF41187.1 - 1.3e-81 274.2 0.0 2.1e-81 273.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 CDF41187.1 - 4.8e-43 147.7 0.0 8.1e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 CDF41187.1 - 8e-21 74.0 0.0 2.2e-20 72.6 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 CDF41187.1 - 8.7e-11 41.8 0.0 1.8e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Fib_succ_major PF09603.10 CDF41187.1 - 0.015 16.0 0.0 0.09 13.4 0.0 2.0 2 0 0 2 2 2 0 Fibrobacter succinogenes major domain (Fib_succ_major) CbiX PF01903.17 CDF41188.1 - 2.6e-28 98.5 0.1 4.5e-28 97.7 0.1 1.4 1 0 0 1 1 1 1 CbiX CbiK PF06180.11 CDF41188.1 - 8.8e-08 31.8 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Ferrochelatase PF00762.19 CDF41188.1 - 0.00099 18.3 0.0 0.0015 17.7 0.0 1.2 1 0 0 1 1 1 1 Ferrochelatase FKBP_C PF00254.28 CDF41190.1 - 1.2e-15 57.6 0.0 2.2e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PAP_assoc PF03828.19 CDF41191.1 - 4.5e-05 23.6 0.1 0.00012 22.2 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDF41191.1 - 0.00026 21.2 0.0 0.00096 19.4 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 CDF41191.1 - 0.034 14.2 0.0 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase PAP_central PF04928.17 CDF41191.1 - 0.085 11.8 1.8 0.15 11.1 0.1 2.3 3 0 0 3 3 3 0 Poly(A) polymerase central domain Uma2 PF05685.12 CDF41193.1 - 3.4e-11 43.0 0.3 1.1e-10 41.4 0.3 1.8 1 1 0 1 1 1 1 Putative restriction endonuclease DUF1635 PF07795.11 CDF41193.1 - 0.00097 19.1 1.2 0.0016 18.3 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) V-SNARE PF05008.15 CDF41193.1 - 0.19 12.1 1.6 0.25 11.7 0.6 1.7 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DivIC PF04977.15 CDF41193.1 - 2.6 7.9 4.9 5.6 6.8 4.9 1.4 1 0 0 1 1 1 0 Septum formation initiator Uma2 PF05685.12 CDF41194.1 - 1.7e-16 60.3 0.4 1.2e-14 54.2 0.3 2.3 1 1 0 1 1 1 1 Putative restriction endonuclease DUF1635 PF07795.11 CDF41194.1 - 0.0042 17.0 1.7 0.0076 16.1 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) V-SNARE PF05008.15 CDF41194.1 - 0.1 13.0 0.6 0.23 11.9 0.6 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DivIC PF04977.15 CDF41194.1 - 1.2 9.0 5.1 2.5 8.0 5.1 1.4 1 0 0 1 1 1 0 Septum formation initiator SET PF00856.28 CDF41197.1 - 8.2e-18 65.4 0.4 5.5e-17 62.7 0.4 2.6 1 1 0 1 1 1 1 SET domain preSET_CXC PF18264.1 CDF41197.1 - 1e-07 32.3 15.5 1e-07 32.3 15.5 3.4 3 0 0 3 3 3 1 CXC domain TCR PF03638.15 CDF41197.1 - 2.5 8.5 39.9 0.45 10.9 16.6 2.9 3 0 0 3 3 3 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Voltage_CLC PF00654.20 CDF41198.1 - 2.2e-74 250.8 20.0 3.4e-74 250.2 20.0 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 CDF41198.1 - 2.5e-12 47.1 0.5 5.8e-07 29.9 0.1 2.6 2 0 0 2 2 2 2 CBS domain Cortexin PF11057.8 CDF41198.1 - 0.04 13.8 0.3 0.12 12.2 0.3 1.8 1 0 0 1 1 1 0 Cortexin of kidney Pex24p PF06398.11 CDF41198.1 - 0.044 12.8 1.0 2.5 7.0 0.3 2.3 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin RT_RNaseH_2 PF17919.1 CDF41202.1 - 2e-13 50.2 0.0 5.1e-13 48.9 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDF41202.1 - 0.0039 16.7 0.1 0.007 15.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CDF41202.1 - 0.0089 16.3 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HTH_15 PF12324.8 CDF41202.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase NMT PF01233.19 CDF41209.1 - 1.8e-19 70.2 0.1 1.9e-19 70.1 0.1 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain UCH PF00443.29 CDF41211.1 - 7.6e-31 107.5 0.0 1.6e-30 106.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDF41211.1 - 6.1e-06 26.0 6.8 7e-05 22.6 6.8 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CDF41211.1 - 0.00047 19.7 0.7 0.016 14.7 0.0 3.0 4 0 0 4 4 4 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase zf-C2HE PF16278.5 CDF41211.1 - 0.026 15.0 0.3 0.094 13.2 0.3 2.0 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger RT_RNaseH PF17917.1 CDF41213.1 - 1.3e-33 115.4 0.0 4.5e-33 113.7 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF41213.1 - 1.9e-33 114.4 0.0 6.4e-33 112.8 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF41213.1 - 1.5e-15 57.0 0.3 3e-15 56.0 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF41213.1 - 7.4e-13 48.7 0.1 1.7e-12 47.6 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CDF41213.1 - 4.5e-09 36.1 0.9 0.0013 18.3 0.0 3.4 1 1 2 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 CDF41213.1 - 0.00035 20.7 0.0 0.0011 19.1 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger Muted PF14942.6 CDF41213.1 - 0.0083 16.5 0.4 0.033 14.5 0.4 2.0 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein TMEM208_SND2 PF05620.11 CDF41215.1 - 0.2 11.5 0.7 0.37 10.6 0.7 1.4 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 GRP PF07172.11 CDF41217.1 - 0.062 14.0 1.2 0.16 12.7 0.1 2.2 2 0 0 2 2 2 0 Glycine rich protein family Dna2 PF08696.11 CDF41218.1 - 1.6e-44 152.1 0.0 3.9e-44 150.9 0.0 1.6 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 CDF41218.1 - 3.6e-35 122.0 0.0 8e-17 61.9 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.6 CDF41218.1 - 4.6e-35 121.1 0.3 2.4e-17 63.2 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 CDF41218.1 - 9.5e-17 61.3 0.0 2.5e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF41218.1 - 1.5e-11 44.8 0.0 3.6e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDF41218.1 - 1e-05 25.4 0.1 2.6 7.7 0.0 4.0 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CDF41218.1 - 4.7e-05 23.1 0.1 0.00025 20.7 0.1 2.2 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain Herpes_ori_bp PF02399.15 CDF41218.1 - 8e-05 20.9 0.1 0.00013 20.2 0.1 1.3 1 0 0 1 1 1 1 Origin of replication binding protein ResIII PF04851.15 CDF41218.1 - 0.00015 21.9 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.6 CDF41218.1 - 0.00033 20.4 0.0 0.00094 19.0 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain T2SSE PF00437.20 CDF41218.1 - 0.00047 19.3 0.1 0.001 18.2 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Helicase_RecD PF05127.14 CDF41218.1 - 0.00063 19.6 0.0 0.0015 18.4 0.0 1.6 1 1 0 1 1 1 1 Helicase SRP54 PF00448.22 CDF41218.1 - 0.0012 18.6 0.1 0.0022 17.7 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 CDF41218.1 - 0.0082 16.5 0.0 0.028 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 CDF41218.1 - 0.01 15.1 0.0 0.06 12.6 0.0 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CDF41218.1 - 0.02 15.2 0.2 0.13 12.5 0.1 2.4 2 1 0 2 2 2 0 AAA domain Terminase_6 PF03237.15 CDF41218.1 - 0.036 13.7 0.0 1.9 8.1 0.0 2.6 2 0 0 2 2 2 0 Terminase-like family FtsK_SpoIIIE PF01580.18 CDF41218.1 - 0.04 13.3 0.0 0.078 12.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family CbiA PF01656.23 CDF41218.1 - 0.07 13.2 0.3 0.24 11.4 0.2 1.9 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 CDF41218.1 - 0.074 12.8 0.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 CDF41218.1 - 0.078 12.9 0.0 0.42 10.5 0.0 2.3 2 0 0 2 2 2 0 NACHT domain DnaB_C PF03796.15 CDF41218.1 - 0.088 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_25 PF13481.6 CDF41218.1 - 0.095 12.3 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CDF41218.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDF41218.1 - 0.1 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 CDF41218.1 - 0.13 12.7 0.0 0.39 11.2 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CDF41218.1 - 0.17 11.2 0.0 0.35 10.2 0.0 1.5 1 0 0 1 1 1 0 KaiC CX PF01705.19 CDF41219.1 - 0.47 11.0 4.0 11 6.6 0.3 2.3 2 0 0 2 2 2 0 CX module AFOR_C PF01314.18 CDF41219.1 - 2.4 7.1 5.7 0.44 9.5 0.5 2.0 1 1 1 2 2 2 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 zf-C2H2_4 PF13894.6 CDF41219.1 - 4.8 8.3 7.7 2 9.5 1.3 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger An_peroxidase PF03098.15 CDF41220.1 - 1.2e-120 403.6 0.5 1.3e-120 403.5 0.5 1.0 1 0 0 1 1 1 1 Animal haem peroxidase BRK PF07533.16 CDF41221.1 - 2.5e-22 78.2 2.7 1e-11 44.3 0.5 2.4 2 0 0 2 2 2 2 BRK domain Ribosomal_S13_N PF08069.12 CDF41221.1 - 0.25 11.4 1.5 23 5.1 0.0 3.3 3 0 0 3 3 3 0 Ribosomal S13/S15 N-terminal domain MBOAT PF03062.19 CDF41223.1 - 1.1e-27 97.4 19.4 1.2e-27 97.2 19.4 1.0 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 CDF41223.1 - 7.9e-05 22.9 6.0 7.9e-05 22.9 6.0 1.6 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Phlebovirus_G1 PF07243.11 CDF41224.1 - 1.9 6.7 6.7 2.8 6.2 6.7 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 Iso_dh PF00180.20 CDF41230.1 - 3.1e-75 253.5 0.2 4.1e-75 253.1 0.2 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Helitron_like_N PF14214.6 CDF41231.1 - 1.5e-47 162.3 0.0 1.5e-47 162.3 0.0 2.5 2 1 1 3 3 3 1 Helitron helicase-like domain at N-terminus AMNp_N PF10423.9 CDF41231.1 - 0.029 14.0 0.0 0.07 12.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus TonB_dep_Rec PF00593.24 CDF41232.1 - 2.2e-07 31.1 57.1 7e-07 29.5 53.7 2.2 1 1 1 2 2 2 1 TonB dependent receptor zf-CCHC_6 PF15288.6 CDF41235.1 - 0.32 10.9 3.9 2.9 7.8 0.7 2.4 1 1 1 2 2 2 0 Zinc knuckle GDC-P PF02347.16 CDF41236.1 - 9.9e-90 301.4 0.1 1.1e-89 301.3 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein APH PF01636.23 CDF41237.1 - 1.6e-08 34.8 0.2 3.3e-08 33.8 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family GidB PF02527.15 CDF41239.1 - 9.5e-41 139.1 0.0 1.2e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_31 PF13847.6 CDF41239.1 - 0.00079 19.2 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDF41239.1 - 0.0034 16.9 0.1 0.0065 16.0 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain APH PF01636.23 CDF41243.1 - 7.7e-09 35.8 0.5 1.3e-08 35.1 0.4 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDF41243.1 - 0.039 13.3 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 CDF41243.1 - 0.096 12.3 0.2 0.19 11.3 0.2 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 CDF41244.1 - 1.3e-09 38.3 1.3 2e-09 37.7 1.3 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Mad3_BUB1_II PF08171.11 CDF41245.1 - 0.14 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 EPSP_synthase PF00275.20 CDF41247.1 - 4.2e-137 457.2 0.0 4.8e-137 457.1 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) SpoU_sub_bind PF08032.12 CDF41247.1 - 0.089 13.1 0.0 13 6.1 0.0 2.4 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding DUF1086 PF06461.11 CDF41249.1 - 0.16 11.9 0.0 0.17 11.7 0.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) MRP-L47 PF06984.13 CDF41250.1 - 6.8e-22 77.4 0.1 9.5e-22 76.9 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 CDF41250.1 - 0.0086 16.0 0.4 0.3 11.1 0.0 2.3 2 0 0 2 2 2 1 Ribosomal L29 protein PPR_2 PF13041.6 CDF41251.1 - 5.7e-05 23.2 0.0 7.3 6.9 0.0 4.6 4 1 1 5 5 5 2 PPR repeat family PPR PF01535.20 CDF41251.1 - 8.4e-05 22.6 0.0 1.9 8.9 0.0 5.2 6 0 0 6 6 6 2 PPR repeat TPR_14 PF13428.6 CDF41251.1 - 0.27 12.2 9.8 0.48 11.4 0.3 5.0 6 2 1 7 7 7 0 Tetratricopeptide repeat RHD3 PF05879.12 CDF41252.1 - 6.2e-22 77.6 0.0 8.7e-22 77.1 0.0 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) 2_5_RNA_ligase2 PF13563.6 CDF41253.1 - 0.036 14.0 0.0 0.061 13.2 0.0 1.4 1 1 0 1 1 1 0 2'-5' RNA ligase superfamily CTP_transf_1 PF01148.20 CDF41256.1 - 8.2e-54 183.1 16.2 1e-53 182.9 16.2 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Sod_Cu PF00080.20 CDF41257.1 - 1.7e-27 96.3 0.6 3.1e-27 95.5 0.5 1.4 2 0 0 2 2 2 1 Copper/zinc superoxide dismutase (SODC) RELT PF12606.8 CDF41257.1 - 0.044 12.8 0.1 0.087 11.8 0.1 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 ThiF PF00899.21 CDF41258.1 - 6.3e-60 202.5 0.1 8.4e-60 202.1 0.1 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 CDF41258.1 - 2.4e-07 31.3 0.0 5.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain TMEM100 PF16311.5 CDF41258.1 - 0.011 15.3 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 100 2-Hacid_dh_C PF02826.19 CDF41258.1 - 0.073 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPR_2 PF07719.17 CDF41259.1 - 1e-26 90.8 0.9 0.00016 21.5 0.1 7.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDF41259.1 - 2.6e-24 83.8 17.2 1.1e-05 25.9 0.2 8.1 2 1 6 8 8 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 CDF41259.1 - 7.3e-19 66.7 0.0 0.0018 18.5 0.0 5.8 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDF41259.1 - 1.7e-17 63.7 0.2 9.1e-06 26.1 0.0 5.3 4 1 3 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDF41259.1 - 1.6e-14 53.9 5.1 9.8e-05 22.6 0.2 6.0 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDF41259.1 - 3e-12 45.8 0.0 0.37 10.7 0.0 6.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDF41259.1 - 5.8e-12 46.1 12.5 0.00041 20.9 0.3 5.3 4 1 3 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDF41259.1 - 1.5e-11 43.6 0.0 1.1 9.7 0.0 7.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDF41259.1 - 9e-07 28.4 7.8 0.86 8.8 0.1 5.8 2 1 3 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDF41259.1 - 2e-06 27.4 0.1 9.8 6.5 0.0 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDF41259.1 - 2.4e-06 27.8 0.3 26 5.7 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDF41259.1 - 1.1e-05 25.0 0.0 4.9 6.9 0.0 5.5 5 1 1 6 6 6 2 TPR repeat MIT PF04212.18 CDF41259.1 - 0.00027 20.9 0.0 3.9 7.6 0.0 4.7 5 0 0 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 CDF41259.1 - 0.0009 19.3 14.7 0.12 12.6 0.2 4.7 2 1 3 5 5 4 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDF41259.1 - 0.0011 19.0 0.1 9.7 6.2 0.0 4.9 4 2 1 6 6 6 0 Mad3/BUB1 homology region 1 PPR PF01535.20 CDF41259.1 - 0.0011 19.1 1.9 16 6.0 0.0 5.3 6 0 0 6 6 5 0 PPR repeat PPR_1 PF12854.7 CDF41259.1 - 0.0099 15.6 5.4 5.1 6.9 0.1 4.7 5 0 0 5 5 5 1 PPR repeat DUF3390 PF11870.8 CDF41259.1 - 0.02 15.3 0.7 12 6.4 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) SBP_bac_11 PF13531.6 CDF41259.1 - 0.048 13.4 0.1 4.3 7.0 0.0 2.4 1 1 1 2 2 2 0 Bacterial extracellular solute-binding protein Eisosome1 PF12757.7 CDF41259.1 - 0.11 12.7 2.2 0.19 12.0 2.2 1.3 1 0 0 1 1 1 0 Eisosome protein 1 TPR_10 PF13374.6 CDF41259.1 - 0.82 9.6 14.6 41 4.2 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat FAD_binding_2 PF00890.24 CDF41260.1 - 1e-118 397.1 4.8 1.3e-118 396.7 4.8 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CDF41260.1 - 8.8e-42 142.1 0.8 1.3e-41 141.5 0.8 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Thi4 PF01946.17 CDF41260.1 - 0.0018 17.5 0.3 0.85 8.8 0.1 2.6 3 0 0 3 3 3 2 Thi4 family Pyr_redox_2 PF07992.14 CDF41260.1 - 0.023 13.9 3.7 0.64 9.2 1.4 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDF41260.1 - 0.026 13.6 2.6 0.53 9.3 2.4 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CDF41260.1 - 0.046 13.0 0.6 0.083 12.1 0.6 1.4 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 CDF41260.1 - 0.21 10.9 4.6 0.7 9.2 3.4 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase MPP6 PF10175.9 CDF41261.1 - 6.2 7.3 14.2 1.5 9.3 6.3 2.3 2 0 0 2 2 2 0 M-phase phosphoprotein 6 Exo_endo_phos PF03372.23 CDF41262.1 - 2.4e-19 69.8 0.0 4e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 CDF41262.1 - 4.8e-13 49.0 3.5 4.8e-13 49.0 3.5 2.0 2 0 0 2 2 2 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 CDF41262.1 - 4e-05 23.4 0.0 0.00087 19.1 0.0 2.8 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase DUF730 PF05325.11 CDF41262.1 - 0.098 12.7 0.1 0.098 12.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF730) DENN PF02141.21 CDF41267.1 - 1.7e-18 67.2 0.3 3.4e-18 66.3 0.3 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 CDF41267.1 - 0.014 16.2 0.2 0.051 14.3 0.0 2.1 2 0 0 2 2 2 0 uDENN domain Pkinase PF00069.25 CDF41268.1 - 1.5e-66 224.4 0.0 2.2e-66 224.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41268.1 - 1.4e-35 122.9 0.0 2e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DEP PF00610.21 CDF41268.1 - 1.1e-21 76.6 0.1 2.1e-21 75.7 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF547 PF04784.14 CDF41268.1 - 2.3e-07 30.9 0.0 5.3e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF547 Kinase-like PF14531.6 CDF41268.1 - 1.8e-05 24.2 0.0 2.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDF41268.1 - 0.00013 21.0 0.0 0.00022 20.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF41268.1 - 0.0038 17.2 0.0 0.21 11.5 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF41268.1 - 0.0042 16.5 0.0 0.0097 15.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ATP-synt_C PF00137.21 CDF41270.1 - 8.7e-26 90.1 28.5 1.9e-14 53.8 8.2 2.2 2 0 0 2 2 2 2 ATP synthase subunit C Pkinase_Tyr PF07714.17 CDF41271.1 - 1.6e-58 198.0 0.0 2.1e-58 197.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDF41271.1 - 3.4e-50 170.9 0.0 4.8e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 CDF41271.1 - 4e-05 22.7 0.0 6.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Glyco_hydro81C PF17652.1 CDF41271.1 - 0.18 11.0 0.2 0.3 10.3 0.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 81 C-terminal domain APH PF01636.23 CDF41271.1 - 0.18 11.7 0.1 0.3 11.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 CDF41272.1 - 5.4e-49 166.9 0.0 7e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41272.1 - 3.8e-27 95.2 0.0 4.6e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDF41272.1 - 0.038 12.8 0.0 0.077 11.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PI-PLC-X PF00388.19 CDF41273.1 - 5.9e-08 32.4 0.0 6.7e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Sel1 PF08238.12 CDF41274.1 - 2e-06 28.3 0.0 0.0056 17.3 0.0 3.0 3 0 0 3 3 3 3 Sel1 repeat CENP-B_N PF04218.13 CDF41275.1 - 0.0045 16.6 1.3 0.0063 16.1 1.3 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Sulfotransfer_2 PF03567.14 CDF41276.1 - 3.5e-10 40.2 0.0 4.9e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Hexapep PF00132.24 CDF41278.1 - 4.3e-23 80.1 16.0 3.1e-08 33.0 3.2 4.3 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) GFO_IDH_MocA PF01408.22 CDF41278.1 - 7.8e-19 68.7 0.5 1.4e-18 67.8 0.5 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Hexapep_2 PF14602.6 CDF41278.1 - 1.3e-12 47.2 15.3 4.9e-07 29.4 2.6 4.4 5 0 0 5 5 5 2 Hexapeptide repeat of succinyl-transferase AlaDh_PNT_C PF01262.21 CDF41278.1 - 0.00049 19.5 0.0 0.00049 19.5 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CDF41278.1 - 0.0038 17.6 0.0 0.0092 16.4 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding XdhC_C PF13478.6 CDF41278.1 - 0.14 12.6 0.2 0.24 11.9 0.2 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain PTH2 PF01981.16 CDF41279.1 - 1.4e-40 138.2 0.1 1.8e-40 137.9 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Romo1 PF10247.9 CDF41279.1 - 0.088 13.2 0.4 5.5 7.4 0.1 2.6 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 Glyco_hydro_16 PF00722.21 CDF41280.1 - 2.8e-13 49.7 0.2 4.1e-13 49.2 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 INCENP_ARK-bind PF03941.15 CDF41283.1 - 1.4e-05 25.0 2.1 1.5e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region DUF4055 PF13264.6 CDF41283.1 - 0.0085 16.2 0.4 0.022 14.9 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4055) GATase PF00117.28 CDF41284.1 - 8.7e-23 81.1 0.0 1e-22 80.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDF41284.1 - 0.014 15.2 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase C26 CTP_synth_N PF06418.14 CDF41285.1 - 1.1e-121 405.2 0.0 1.6e-121 404.6 0.0 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CDF41285.1 - 0.00083 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CbiA PF01656.23 CDF41285.1 - 0.0023 18.0 0.0 0.0032 17.5 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain zf-RING_2 PF13639.6 CDF41286.1 - 3.9e-11 43.1 4.1 8e-11 42.1 4.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDF41286.1 - 3.2e-10 40.1 3.1 6.6e-10 39.1 3.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDF41286.1 - 3.8e-09 36.2 3.7 7.2e-09 35.4 3.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF41286.1 - 2.6e-08 33.6 2.7 4.9e-08 32.7 2.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDF41286.1 - 2.9e-07 30.1 0.9 5.5e-07 29.2 0.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 CDF41286.1 - 7.8e-06 25.9 0.8 1.7e-05 24.8 0.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 CDF41286.1 - 6.5e-05 22.7 1.8 0.00012 21.8 1.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDF41286.1 - 0.00058 19.8 3.3 0.0016 18.4 3.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDF41286.1 - 0.0034 17.3 2.6 0.0064 16.4 2.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDF41286.1 - 0.0049 17.0 3.3 0.005 17.0 0.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 CDF41286.1 - 0.017 15.4 2.1 0.039 14.3 2.1 1.6 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 CDF41286.1 - 0.02 15.1 3.0 0.07 13.3 3.0 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CDF41286.1 - 0.022 14.4 3.4 0.044 13.4 3.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 CDF41286.1 - 0.026 14.6 4.5 0.064 13.4 4.5 1.7 1 0 0 1 1 1 0 RING-variant domain Prok-RING_4 PF14447.6 CDF41286.1 - 0.029 14.2 3.3 0.08 12.8 3.3 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CDF41286.1 - 0.051 13.4 3.2 0.098 12.5 3.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prim_Zn_Ribbon PF08273.12 CDF41286.1 - 0.082 13.2 2.4 0.75 10.1 0.8 2.3 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase BatD PF13584.6 CDF41286.1 - 0.099 11.4 0.0 0.23 10.2 0.0 1.6 1 1 1 2 2 2 0 Oxygen tolerance zf-Nse PF11789.8 CDF41286.1 - 0.12 12.2 0.5 0.23 11.3 0.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_5 PF17121.5 CDF41286.1 - 0.25 11.2 0.8 0.5 10.3 0.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 CDF41286.1 - 0.49 10.3 7.0 0.87 9.5 5.0 2.3 1 1 1 2 2 2 0 PHD-finger Integrase_H2C2 PF17921.1 CDF41288.1 - 1.7e-14 53.7 0.7 3.5e-14 52.7 0.2 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 CDF41288.1 - 1.5e-09 37.7 2.0 0.0017 18.0 0.0 3.7 3 1 1 4 4 4 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CDF41288.1 - 3.1e-08 33.9 0.0 7.6e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF41288.1 - 7.1e-08 32.4 0.5 4.3e-07 29.9 0.0 2.4 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 CDF41288.1 - 0.0014 18.8 0.1 0.0048 17.1 0.1 2.0 2 0 0 2 2 2 1 H2C2 zinc finger rve PF00665.26 CDF41288.1 - 0.0067 16.6 0.0 1.3 9.2 0.0 2.8 3 0 0 3 3 3 1 Integrase core domain Gelsolin PF00626.22 CDF41289.1 - 4.7e-28 96.9 0.3 4.1e-14 52.2 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat KASH_CCD PF14662.6 CDF41290.1 - 0.00018 21.4 25.8 0.00018 21.4 25.8 4.5 3 1 1 4 4 4 2 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 CDF41290.1 - 0.00079 19.6 9.0 0.0028 17.8 2.1 7.8 8 1 0 8 8 7 2 Homeobox associated leucine zipper Spc7 PF08317.11 CDF41290.1 - 0.0012 17.7 20.5 0.0012 17.7 20.5 4.4 1 1 2 4 4 4 2 Spc7 kinetochore protein Hemagglutinin PF00509.18 CDF41290.1 - 0.0034 15.8 1.5 0.0034 15.8 1.5 2.7 1 1 2 3 3 3 1 Haemagglutinin Filament PF00038.21 CDF41290.1 - 0.0043 16.7 39.8 0.0043 16.7 39.8 4.9 2 1 2 4 4 4 2 Intermediate filament protein YabA PF06156.13 CDF41290.1 - 0.0088 16.7 45.0 0.48 11.1 1.7 6.5 2 1 3 6 6 6 3 Initiation control protein YabA DUF1664 PF07889.12 CDF41290.1 - 0.016 15.3 5.1 0.016 15.3 5.1 6.0 2 1 5 7 7 7 0 Protein of unknown function (DUF1664) Sacchrp_dh_C PF16653.5 CDF41290.1 - 0.017 15.2 1.0 0.028 14.5 1.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain PI_PP_I PF18363.1 CDF41290.1 - 0.24 11.6 3.8 0.51 10.6 1.0 3.0 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain TPR_MLP1_2 PF07926.12 CDF41290.1 - 0.56 10.3 76.2 0.039 14.0 16.2 5.7 2 1 3 5 5 5 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 CDF41290.1 - 0.82 9.0 73.7 0.33 10.3 11.4 5.9 2 1 5 7 7 7 0 Growth-arrest specific micro-tubule binding DUF1192 PF06698.11 CDF41290.1 - 1.4 9.1 0.0 1.4 9.1 0.0 5.7 6 2 1 7 7 7 0 Protein of unknown function (DUF1192) SHE3 PF17078.5 CDF41290.1 - 4.2 7.0 55.5 0.19 11.4 13.4 4.6 2 1 3 5 5 5 0 SWI5-dependent HO expression protein 3 APG6_N PF17675.1 CDF41290.1 - 5.4 7.6 88.5 1.1 9.8 11.0 6.1 2 1 4 6 6 6 0 Apg6 coiled-coil region DUF4472 PF14739.6 CDF41290.1 - 6.9 7.5 59.1 4.9 7.9 1.8 6.5 3 3 0 5 5 5 0 Domain of unknown function (DUF4472) AMP-binding PF00501.28 CDF41291.1 - 8.1e-102 341.0 0.0 9.7e-102 340.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Glyco_transf_11 PF01531.16 CDF41293.1 - 0.0011 18.3 0.1 0.0018 17.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 11 HTH_18 PF12833.7 CDF41297.1 - 0.043 14.1 0.3 0.084 13.2 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain ABC1 PF03109.16 CDF41298.1 - 2.8e-28 98.5 0.0 4.2e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 CDF41299.1 - 1.1e-25 90.6 0.0 3.3e-25 89.0 0.0 1.5 1 1 1 2 2 2 1 Protein kinase domain Peptidase_C97 PF05903.14 CDF41299.1 - 3.3e-16 59.5 0.0 4.8e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain Pkinase_Tyr PF07714.17 CDF41299.1 - 1.4e-08 34.4 0.0 3.1e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 CDF41299.1 - 0.026 14.1 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Y_Y_Y PF07495.13 CDF41303.1 - 0.06 13.3 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 Y_Y_Y domain PIF1 PF05970.14 CDF41308.1 - 3e-90 303.0 0.0 4.5e-90 302.4 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF41308.1 - 9.7e-60 202.0 0.0 2.5e-59 200.7 0.0 1.8 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF41308.1 - 1.4e-06 28.1 0.0 2.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AMNp_N PF10423.9 CDF41308.1 - 0.053 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Herpes_Helicase PF02689.14 CDF41308.1 - 0.092 10.6 0.0 0.15 10.0 0.0 1.2 1 0 0 1 1 1 0 Helicase SNF2_N PF00176.23 CDF41309.1 - 2.3e-51 174.5 0.0 5.9e-51 173.2 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF41309.1 - 7.3e-17 61.7 0.0 2e-16 60.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDF41309.1 - 9.1e-09 35.5 0.0 2e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF41309.1 - 0.00014 21.7 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CDF41309.1 - 0.089 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Peptidase_M14 PF00246.24 CDF41310.1 - 2.6e-28 99.7 0.0 3e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF347 PF03988.12 CDF41310.1 - 0.0039 17.3 5.4 3.1 8.0 4.0 3.0 1 1 1 2 2 2 2 Repeat of Unknown Function (DUF347) Cse1 PF08506.10 CDF41314.1 - 1.2e-08 34.2 0.0 3.9e-07 29.2 0.0 2.7 2 1 0 2 2 2 1 Cse1 HEAT_2 PF13646.6 CDF41314.1 - 0.0055 17.1 1.1 0.04 14.3 0.1 3.1 3 1 0 3 3 3 1 HEAT repeats HEAT PF02985.22 CDF41314.1 - 0.49 10.8 4.0 46 4.7 0.1 5.2 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 CDF41314.1 - 1.1 9.8 6.9 0.83 10.2 1.0 3.9 3 1 0 3 3 3 0 HEAT-like repeat Acetyltransf_1 PF00583.25 CDF41318.1 - 2.9e-15 56.5 0.0 4e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDF41318.1 - 1.1e-10 41.8 0.0 1.7e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDF41318.1 - 1.2e-10 41.2 0.1 3.1e-10 39.9 0.1 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 CDF41318.1 - 1.8e-09 37.6 0.0 2.5e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CDF41318.1 - 3.1e-05 23.7 0.0 3.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDF41318.1 - 9.8e-05 22.4 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDF41318.1 - 0.00027 21.1 0.0 0.00036 20.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 CDF41318.1 - 0.0026 17.4 0.1 0.0035 17.0 0.1 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_3 PF13302.7 CDF41318.1 - 0.0088 16.7 0.0 0.011 16.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2982 PF11201.8 CDF41318.1 - 0.068 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2982) SNase PF00565.17 CDF41319.1 - 1.8e-46 157.1 0.0 1.6e-12 47.8 0.0 5.3 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 CDF41319.1 - 2.8e-13 50.0 0.0 5.4e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Tudor domain POTRA_3 PF17287.2 CDF41319.1 - 0.062 12.8 0.0 0.27 10.7 0.0 2.0 2 0 0 2 2 2 0 POTRA domain Exo_endo_phos PF03372.23 CDF41320.1 - 0.00068 19.2 0.1 0.0017 17.9 0.1 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sigma70_ner PF04546.13 CDF41320.1 - 0.051 13.5 2.4 0.092 12.6 2.4 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.10 CDF41320.1 - 0.34 11.3 20.7 0.8 10.1 20.7 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ORC6 PF05460.13 CDF41320.1 - 1 8.5 4.7 2.1 7.6 4.7 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SDA1 PF05285.12 CDF41320.1 - 4.4 6.6 9.2 8.6 5.7 9.2 1.4 1 0 0 1 1 1 0 SDA1 Alpha_kinase PF02816.18 CDF41321.1 - 1.2e-32 113.5 0.0 1.6e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family GAS2 PF02187.17 CDF41322.1 - 0.15 12.2 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain zf-RING_2 PF13639.6 CDF41325.1 - 3.1e-09 37.0 17.4 3.3e-09 36.9 15.8 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDF41325.1 - 4.2e-09 36.0 4.6 4.2e-09 36.0 4.6 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 CDF41325.1 - 5e-05 23.5 12.2 5e-05 23.5 12.2 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDF41325.1 - 0.0004 20.4 8.0 0.00085 19.3 8.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDF41325.1 - 0.00041 20.1 15.3 0.00041 20.1 15.3 2.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDF41325.1 - 0.021 14.7 16.1 0.021 14.7 16.1 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDF41325.1 - 0.031 13.9 14.1 0.042 13.5 13.3 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 CDF41325.1 - 0.053 13.5 14.7 0.13 12.2 14.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDF41325.1 - 4.2 7.6 14.4 18 5.6 13.8 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CDF41326.1 - 4.4e-07 30.1 12.2 1.1e-06 28.8 12.2 1.8 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 CDF41326.1 - 0.0017 18.5 7.0 0.004 17.3 7.0 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 CDF41326.1 - 0.0019 18.2 2.6 0.005 16.9 2.6 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger C1_1 PF00130.22 CDF41326.1 - 0.013 15.3 4.6 0.031 14.1 4.6 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Luciferase_N PF05295.11 CDF41326.1 - 0.055 13.5 0.1 0.44 10.6 0.0 2.3 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain zf-C3HC4_2 PF13923.6 CDF41326.1 - 0.1 12.5 12.2 0.28 11.0 12.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDF41326.1 - 0.11 12.1 7.5 0.29 10.8 7.5 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 CDF41326.1 - 0.12 12.5 9.9 0.28 11.3 9.9 1.7 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 CDF41326.1 - 0.16 12.1 4.5 0.52 10.5 4.5 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger zf-rbx1 PF12678.7 CDF41326.1 - 0.16 12.3 11.5 0.61 10.4 11.6 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain MrpF_PhaF PF04066.13 CDF41326.1 - 0.3 11.5 3.0 17 5.9 0.1 2.9 2 0 0 2 2 2 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) zf-C3HC4 PF00097.25 CDF41326.1 - 0.37 10.7 12.6 0.85 9.5 12.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 CDF41326.1 - 1.6 8.7 8.7 3.4 7.6 8.7 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 CDF41326.1 - 3.2 8.1 9.7 0.86 10.0 6.1 2.0 2 0 0 2 2 1 0 RING-like domain zf-RING_UBOX PF13445.6 CDF41326.1 - 5.7 7.1 9.0 14 5.8 9.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger FYVE PF01363.21 CDF41326.1 - 9.6 6.4 9.8 1.1e+02 3.0 9.5 2.5 1 1 0 1 1 1 0 FYVE zinc finger DUF4834 PF16118.5 CDF41327.1 - 0.21 12.5 0.0 0.78 10.7 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2207 PF09972.9 CDF41327.1 - 0.27 10.0 0.1 0.41 9.4 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ANAPC5 PF12862.7 CDF41329.1 - 0.065 13.3 0.5 0.28 11.3 0.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Transcrip_act PF04949.13 CDF41329.1 - 0.07 13.0 0.1 0.24 11.3 0.1 1.9 1 0 0 1 1 1 0 Transcriptional activator DUF3084 PF11283.8 CDF41329.1 - 0.2 11.6 0.3 31 4.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3084) TPR_12 PF13424.6 CDF41329.1 - 4.5 7.6 7.2 9.8 6.6 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDF41329.1 - 5.7 7.3 4.9 11 6.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF41329.1 - 7.3 7.3 8.2 46 4.8 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 CDF41330.1 - 2.1e-32 110.6 13.1 1.5e-06 28.8 0.0 9.4 10 0 0 10 10 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF41330.1 - 3e-18 65.9 0.0 0.00017 21.8 0.0 7.1 4 1 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CDF41330.1 - 8.9e-16 58.1 0.1 1.5e-15 57.4 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 CDF41330.1 - 7.2e-07 28.5 2.0 0.00052 19.1 0.0 4.5 4 2 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF41330.1 - 3.7e-05 23.2 0.0 0.0046 16.3 0.0 2.3 2 0 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 CDF41330.1 - 0.0015 18.4 0.0 0.032 14.1 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 CDF41330.1 - 0.0033 16.7 0.3 2.1 7.5 0.1 3.4 4 1 1 5 5 5 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.8 CDF41330.1 - 0.0074 15.0 0.2 0.06 12.0 0.0 2.6 2 2 1 3 3 3 1 Nucleoporin Nup120/160 Lactonase PF10282.9 CDF41330.1 - 0.05 12.9 0.0 0.98 8.6 0.0 2.7 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller DUF1513 PF07433.11 CDF41330.1 - 0.13 11.3 1.5 14 4.7 0.1 3.3 2 2 2 4 4 4 0 Protein of unknown function (DUF1513) PQQ_3 PF13570.6 CDF41330.1 - 2.9 8.5 6.6 4.3 8.0 0.0 4.5 5 0 0 5 5 4 0 PQQ-like domain TruB_C PF09142.11 CDF41330.1 - 5.9 6.7 8.8 6 6.7 0.3 4.8 6 0 0 6 6 6 0 tRNA Pseudouridine synthase II, C terminal NatB_MDM20 PF09797.9 CDF41336.1 - 6.4e-58 196.5 0.0 1.3e-57 195.5 0.0 1.5 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 CDF41336.1 - 1.4e-07 31.9 5.6 0.0015 19.0 3.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDF41336.1 - 0.041 14.0 2.5 33 4.9 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDF41336.1 - 0.48 11.1 17.6 1.2 9.8 7.7 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDF41336.1 - 0.61 11.1 6.1 80 4.5 1.6 5.4 4 2 1 5 5 5 0 Tetratricopeptide repeat Neur_chan_memb PF02932.16 CDF41337.1 - 0.03 14.4 0.0 0.037 14.1 0.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ank_5 PF13857.6 CDF41338.1 - 1.2e-10 41.4 0.9 3.3e-05 24.1 0.0 3.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDF41338.1 - 1.9e-08 34.7 0.4 0.066 13.8 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDF41338.1 - 3.2e-08 34.0 0.1 2e-05 25.1 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 CDF41338.1 - 2e-07 31.2 5.8 3.5e-06 27.2 0.1 3.7 3 1 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 CDF41338.1 - 1.4e-05 25.1 2.5 0.43 11.3 0.1 5.4 6 1 0 6 6 6 2 Ankyrin repeat F-box-like PF12937.7 CDF41338.1 - 4.5e-05 23.3 0.1 0.00026 20.8 0.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CDF41338.1 - 0.00025 20.9 0.1 0.00091 19.0 0.0 2.0 2 0 0 2 2 2 1 F-box domain Transp_Tc5_C PF04236.15 CDF41340.1 - 2.7 8.4 10.5 11 6.4 0.4 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Cpn60_TCP1 PF00118.24 CDF41345.1 - 2.2e-158 527.9 3.7 2.5e-158 527.7 3.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CPT PF07931.12 CDF41345.1 - 0.04 13.8 0.0 3.4 7.5 0.1 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein SeleniumBinding PF11524.8 CDF41345.1 - 0.12 12.9 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 Selenium binding protein DEAD PF00270.29 CDF41346.1 - 1.2e-17 64.2 0.0 1.9e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDF41346.1 - 2.6e-14 53.5 0.0 1.1e-12 48.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CDF41346.1 - 2.3e-11 44.2 0.1 5.9e-11 42.9 0.1 1.8 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 CDF41346.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CCT PF06203.14 CDF41347.1 - 1.7e-11 43.9 15.5 3.2e-11 43.1 15.5 1.4 1 0 0 1 1 1 1 CCT motif SVIP PF15811.5 CDF41348.1 - 0.95 10.0 6.7 3.7 8.1 6.7 1.9 1 1 0 1 1 1 0 Small VCP/p97-interacting protein Pkinase PF00069.25 CDF41350.1 - 1.7e-63 214.5 0.0 1.6e-62 211.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41350.1 - 9.3e-33 113.6 0.0 2.7e-31 108.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF41350.1 - 9e-07 28.5 0.0 1.8e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDF41350.1 - 0.00069 18.7 0.0 0.001 18.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDF41350.1 - 0.0021 18.0 0.4 0.011 15.7 0.0 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family NPIP PF06409.11 CDF41350.1 - 0.019 14.0 0.4 0.028 13.5 0.4 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Kdo PF06293.14 CDF41350.1 - 0.044 13.1 0.0 0.34 10.2 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tfb4 PF03850.14 CDF41350.1 - 0.19 11.2 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Tfb4 CobN-Mg_chel PF02514.16 CDF41351.1 - 0 1141.4 0.0 0 1141.2 0.0 1.0 1 0 0 1 1 1 1 CobN/Magnesium Chelatase DUF3479 PF11965.8 CDF41351.1 - 2.8e-49 167.3 0.2 5.9e-49 166.3 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3479) vWA-TerF-like PF10138.9 CDF41351.1 - 0.12 12.5 0.1 0.34 11.0 0.1 1.8 1 0 0 1 1 1 0 vWA found in TerF C terminus ATE_C PF04377.15 CDF41352.1 - 6.4e-51 172.5 2.2 1.2e-50 171.6 2.2 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CDF41352.1 - 1.4e-24 86.3 1.0 3.7e-24 84.9 1.0 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Arg_tRNA_synt_N PF03485.16 CDF41352.1 - 0.0048 17.5 0.0 0.01 16.4 0.0 1.6 1 1 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Acetyltransf_6 PF13480.7 CDF41352.1 - 0.11 12.7 0.3 0.39 10.9 0.0 2.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Methyltransf_11 PF08241.12 CDF41353.1 - 1.9e-20 73.3 0.0 2.8e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDF41353.1 - 1.1e-18 67.7 0.0 1.6e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDF41353.1 - 4.8e-15 55.5 0.0 6.5e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDF41353.1 - 1.6e-13 50.8 0.0 2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF41353.1 - 2.9e-13 50.4 0.0 5e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF41353.1 - 2e-07 31.0 0.0 2.7e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CDF41353.1 - 0.0034 16.7 0.0 0.0054 16.1 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase domain GidB PF02527.15 CDF41353.1 - 0.018 14.4 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MTS PF05175.14 CDF41353.1 - 0.049 13.2 0.0 0.26 10.8 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase small domain RrnaAD PF00398.20 CDF41353.1 - 0.061 12.4 0.0 0.084 11.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.19 CDF41353.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) WD40 PF00400.32 CDF41354.1 - 1.8e-05 25.4 2.8 6.7 7.8 0.1 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF41354.1 - 0.00013 22.2 0.0 14 6.1 0.0 4.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDF41354.1 - 0.044 13.4 0.0 11 5.6 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain Sybindin PF04099.12 CDF41355.1 - 1.2e-21 77.1 0.1 1.3e-21 77.0 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CDF41355.1 - 5.9e-07 29.7 0.0 6.1e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Atx10homo_assoc PF09759.9 CDF41357.1 - 4.5e-20 71.5 4.3 7.1e-06 26.0 0.0 5.3 3 1 3 6 6 6 5 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 CDF41357.1 - 9.8e-20 69.9 16.0 0.00022 21.1 0.0 9.1 10 1 0 10 10 10 6 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 CDF41357.1 - 1.9e-05 24.2 3.0 0.00032 20.3 0.1 3.8 3 2 2 5 5 5 1 Armadillo-like PUL PF08324.11 CDF41357.1 - 0.00013 21.3 5.8 0.2 10.8 2.9 3.3 2 1 0 2 2 2 2 PUL domain FAM92 PF06730.11 CDF41357.1 - 0.024 14.0 0.5 2.3 7.6 0.0 3.0 3 1 1 4 4 4 0 FAM92 protein Cytochrome-c551 PF10643.9 CDF41357.1 - 0.058 13.0 1.6 0.8 9.2 0.2 3.1 4 1 0 4 4 4 0 Photosystem P840 reaction-centre cytochrome c-551 Ric8 PF10165.9 CDF41357.1 - 0.1 11.6 0.6 0.76 8.7 0.6 2.2 1 1 0 1 1 1 0 Guanine nucleotide exchange factor synembryn Glyco_transf_90 PF05686.12 CDF41358.1 - 3.8e-29 101.8 0.2 1.4e-28 100.0 0.2 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 90 Ndc1_Nup PF09531.10 CDF41358.1 - 1.6 7.3 4.9 2.2 6.9 4.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup p450 PF00067.22 CDF41359.1 - 2.7e-67 227.5 0.0 3.3e-67 227.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AP3D1 PF06375.11 CDF41360.1 - 8.2 6.6 10.2 6.7 6.9 2.0 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Pkinase PF00069.25 CDF41361.1 - 2.3e-34 118.9 0.0 1.3e-19 70.6 0.0 3.2 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41361.1 - 2.5e-08 33.5 0.0 0.0073 15.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Motilin_ghrelin PF04644.12 CDF41362.1 - 0.66 9.8 4.8 1.2 9.0 4.8 1.4 1 0 0 1 1 1 0 Motilin/ghrelin UDPGT PF00201.18 CDF41363.1 - 0.00038 19.4 0.0 0.00082 18.3 0.0 1.5 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 CDF41363.1 - 0.0014 18.7 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 CDF41363.1 - 0.15 12.0 0.0 0.54 10.2 0.1 1.8 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain CobN-Mg_chel PF02514.16 CDF41364.1 - 7.9e-278 924.6 0.0 6.5e-277 921.6 0.0 1.9 1 1 0 1 1 1 1 CobN/Magnesium Chelatase DUF3479 PF11965.8 CDF41364.1 - 9.1e-15 55.1 0.2 3.3e-14 53.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3479) TSP_3 PF02412.18 CDF41366.1 - 0.00086 18.9 2.2 0.00086 18.9 2.2 30.1 8 7 21 31 31 31 13 Thrombospondin type 3 repeat TQ PF18202.1 CDF41366.1 - 0.0029 18.1 21.3 5.8 7.5 0.7 6.6 2 1 3 6 6 6 5 T-Q ester bond containing domain Toxin_ToxA PF11584.8 CDF41369.1 - 0.0087 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Proteinaceous host-selective toxin ToxA YL1 PF05764.13 CDF41371.1 - 0.0058 16.8 13.2 0.0065 16.6 13.2 1.0 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 CDF41371.1 - 0.023 13.0 7.9 0.024 12.9 7.9 1.0 1 0 0 1 1 1 0 CDC45-like protein NinG PF05766.12 CDF41371.1 - 0.041 13.8 4.4 0.045 13.7 4.4 1.1 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein CPSF100_C PF13299.6 CDF41371.1 - 0.081 13.1 4.5 0.098 12.8 4.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spt5_N PF11942.8 CDF41371.1 - 0.11 13.5 16.1 0.14 13.2 16.1 1.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal RNA_polI_A34 PF08208.11 CDF41371.1 - 0.12 12.5 12.2 0.13 12.4 12.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Presenilin PF01080.17 CDF41371.1 - 0.35 9.6 1.0 0.35 9.6 1.0 1.0 1 0 0 1 1 1 0 Presenilin UPF0239 PF06783.11 CDF41371.1 - 0.35 11.1 6.7 0.46 10.7 6.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) RR_TM4-6 PF06459.12 CDF41371.1 - 0.61 9.9 8.7 0.67 9.7 8.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_pol_Rpc4 PF05132.14 CDF41371.1 - 0.83 10.1 4.9 0.98 9.8 4.9 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Connexin PF00029.19 CDF41371.1 - 1.6 8.5 4.5 1.7 8.3 4.5 1.1 1 0 0 1 1 1 0 Connexin GOLD_2 PF13897.6 CDF41371.1 - 2.8 8.4 5.9 3.1 8.3 5.9 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking PAC1 PF16094.5 CDF41371.1 - 3.2 6.8 8.8 3.6 6.7 8.8 1.1 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 YqfQ PF14181.6 CDF41371.1 - 8 6.6 8.3 9 6.5 8.3 1.1 1 0 0 1 1 1 0 YqfQ-like protein Atrophin-1 PF03154.15 CDF41371.1 - 9 4.4 13.8 10 4.3 13.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family Citrate_synt PF00285.21 CDF41372.1 - 1.5e-111 373.0 0.0 1.7e-111 372.8 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Citrate_synt PF00285.21 CDF41373.1 - 1.4e-45 156.0 0.0 1.5e-45 155.8 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain TMEM208_SND2 PF05620.11 CDF41374.1 - 0.0012 18.6 5.9 0.23 11.2 0.0 2.8 3 0 0 3 3 3 2 SRP-independent targeting protein 2/TMEM208 LZ_Tnp_IS66 PF13007.7 CDF41374.1 - 0.014 16.1 2.3 4.1 8.3 1.2 2.3 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain DUF2070 PF09843.9 CDF41374.1 - 0.097 10.9 1.4 0.17 10.2 1.4 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) eIF3_subunit PF08597.10 CDF41374.1 - 0.12 12.2 14.1 1.6 8.6 0.3 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Peptidase_S49_N PF08496.10 CDF41374.1 - 0.31 11.1 5.8 3 7.9 0.1 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SPT6_acidic PF14632.6 CDF41374.1 - 0.95 10.1 15.7 1.2 9.8 10.0 2.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 DUF1041 PF06292.17 CDF41374.1 - 1.9 8.9 3.8 18 5.8 0.1 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1041) WD40 PF00400.32 CDF41376.1 - 8.8e-81 263.7 51.6 2.5e-07 31.3 0.8 11.9 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF41376.1 - 8.6e-26 90.1 15.5 0.18 12.1 0.1 10.8 2 1 9 11 11 10 10 Anaphase-promoting complex subunit 4 WD40 domain NB-ARC PF00931.22 CDF41376.1 - 3.1e-15 56.1 0.0 6.4e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Me-amine-dh_H PF06433.11 CDF41376.1 - 7.4e-11 41.5 2.8 0.078 11.8 0.1 5.1 1 1 5 6 6 6 5 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.8 CDF41376.1 - 1.1e-07 30.9 13.0 1.2 7.7 0.2 8.8 1 1 7 10 10 10 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 CDF41376.1 - 3.3e-06 26.9 43.2 0.0034 17.0 17.7 4.6 1 1 2 3 3 3 3 PQQ-like domain Ge1_WD40 PF16529.5 CDF41376.1 - 4.2e-05 22.7 9.6 2.2 7.2 0.0 8.1 2 2 8 10 10 10 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDF41376.1 - 0.00013 21.4 0.3 2.4 7.4 0.0 6.1 4 3 5 9 9 9 1 WD40-like domain PQQ_3 PF13570.6 CDF41376.1 - 0.0091 16.5 20.0 23 5.7 0.1 8.8 7 3 3 10 10 9 0 PQQ-like domain PQQ PF01011.21 CDF41376.1 - 0.0098 15.8 13.4 14 5.8 0.1 8.2 9 0 0 9 9 9 0 PQQ enzyme repeat NACHT PF05729.12 CDF41376.1 - 0.016 15.2 0.0 0.076 12.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 CDF41376.1 - 0.081 13.2 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF1207 PF06727.11 CDF41376.1 - 0.39 9.6 2.0 38 3.0 0.0 3.8 3 2 2 5 5 5 0 Protein of unknown function (DUF1207) Peptidase_S9_N PF02897.15 CDF41376.1 - 1.1 8.0 15.3 7.6 5.2 0.1 6.1 2 2 5 8 8 8 0 Prolyl oligopeptidase, N-terminal beta-propeller domain ChapFlgA PF13144.6 CDF41376.1 - 1.5 8.9 10.3 18 5.4 0.4 6.0 5 2 1 6 6 6 0 Chaperone for flagella basal body P-ring formation MFS_5 PF05631.14 CDF41384.1 - 8e-115 383.5 15.4 1.3e-114 382.8 15.4 1.3 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 CDF41384.1 - 6.7e-18 64.7 31.1 1.2e-09 37.6 25.5 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily UPF0016 PF01169.19 CDF41385.1 - 1.5e-41 140.6 23.1 5.5e-21 74.7 5.9 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Ion_trans PF00520.31 CDF41385.1 - 0.052 12.8 0.0 0.095 11.9 0.0 1.5 1 1 0 1 1 1 0 Ion transport protein DUF4131 PF13567.6 CDF41385.1 - 0.87 9.2 4.1 0.43 10.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) PhoR PF11808.8 CDF41385.1 - 8.2 6.9 8.1 0.33 11.4 0.9 2.3 2 1 0 2 2 2 0 Phosphate regulon sensor protein PhoR PAP2 PF01569.21 CDF41387.1 - 0.0036 17.1 0.0 0.008 16.0 0.0 1.6 1 0 0 1 1 1 1 PAP2 superfamily Col_cuticle_N PF01484.17 CDF41387.1 - 0.087 12.9 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain DUF2007 PF09413.10 CDF41387.1 - 0.18 12.0 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein Sulfotransfer_2 PF03567.14 CDF41388.1 - 1.8e-10 41.2 0.2 3.7e-10 40.1 0.2 1.5 1 0 0 1 1 1 1 Sulfotransferase family TRAM_2 PF18693.1 CDF41390.1 - 5e-17 61.8 0.0 7.7e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 TRAM domain Radical_SAM PF04055.21 CDF41390.1 - 9e-07 29.4 0.0 1.5e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily NCA2 PF08637.10 CDF41391.1 - 7.7e-31 107.3 2.8 7.7e-31 107.3 2.8 1.8 2 1 0 2 2 2 1 ATP synthase regulation protein NCA2 DXP_reductoisom PF02670.16 CDF41392.1 - 6.7e-47 159.4 0.3 1.3e-46 158.5 0.3 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.6 CDF41392.1 - 3.1e-36 124.1 0.0 3.3e-35 120.8 0.0 2.3 2 0 0 2 2 2 1 DXP reductoisomerase C-terminal domain DXP_redisom_C PF08436.12 CDF41392.1 - 3.8e-36 123.1 0.0 8.3e-36 122.0 0.0 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain PrpR_N PF06506.11 CDF41392.1 - 0.024 14.2 0.1 7.6 6.1 0.0 2.4 2 0 0 2 2 2 0 Propionate catabolism activator Semialdhyde_dh PF01118.24 CDF41392.1 - 0.035 14.6 0.0 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain LETM1 PF07766.13 CDF41393.1 - 4.3e-14 52.5 0.1 8.4e-14 51.5 0.1 1.4 1 0 0 1 1 1 1 LETM1-like protein Mei5 PF10376.9 CDF41393.1 - 0.15 11.9 1.5 0.27 11.1 1.5 1.4 1 0 0 1 1 1 0 Double-strand recombination repair protein OTU PF02338.19 CDF41394.1 - 1.2e-14 54.9 0.0 1.5e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CDF41394.1 - 4e-08 33.0 0.0 0.00055 19.5 0.0 2.1 2 0 0 2 2 2 2 Peptidase C65 Otubain Sulfotransfer_2 PF03567.14 CDF41395.1 - 2.3e-11 44.1 0.3 4.9e-11 43.0 0.3 1.6 1 1 1 2 2 2 1 Sulfotransferase family SNARE PF05739.19 CDF41396.1 - 1.2e-11 44.4 0.5 1.2e-11 44.4 0.5 2.0 2 0 0 2 2 1 1 SNARE domain Syntaxin_2 PF14523.6 CDF41396.1 - 0.0019 18.5 8.8 0.0019 18.5 4.8 2.2 2 0 0 2 2 2 1 Syntaxin-like protein Syntaxin PF00804.25 CDF41396.1 - 0.0026 17.5 5.4 0.0054 16.4 5.4 1.5 1 1 0 1 1 1 1 Syntaxin MCPsignal PF00015.21 CDF41396.1 - 0.016 15.1 1.2 0.049 13.4 0.1 2.0 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain MetOD2 PF18548.1 CDF41396.1 - 0.025 14.7 0.3 7.3 6.8 0.3 2.6 1 1 1 2 2 2 0 Metanogen output domain 2 Mer2 PF09074.10 CDF41396.1 - 0.099 12.4 7.9 0.043 13.6 4.8 1.7 1 1 0 2 2 2 0 Mer2 PGA2 PF07543.12 CDF41396.1 - 0.16 12.0 4.6 0.18 11.8 1.4 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 Prominin PF05478.11 CDF41396.1 - 0.43 8.5 8.1 1.3 6.9 8.1 1.6 1 1 0 1 1 1 0 Prominin Baculo_PEP_C PF04513.12 CDF41396.1 - 0.52 10.3 6.9 8.3 6.5 0.3 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BBP1_C PF15272.6 CDF41396.1 - 0.55 10.0 8.8 0.44 10.3 2.8 2.2 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal DUF2203 PF09969.9 CDF41396.1 - 0.59 10.9 5.5 2e+02 2.7 5.5 3.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.12 CDF41396.1 - 1.3 9.1 3.7 22 5.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDF41396.1 - 3.3 8.0 11.0 10 6.4 1.2 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CDF41396.1 - 3.7 7.6 7.2 4.5 7.3 1.2 2.6 2 1 1 3 3 3 0 Laminin Domain II DUF4061 PF13270.6 CDF41396.1 - 3.8 7.9 8.0 1.1 9.6 2.9 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) Syntaxin-6_N PF09177.11 CDF41396.1 - 3.9 8.1 10.1 0.82 10.3 3.1 2.8 2 2 0 2 2 2 0 Syntaxin 6, N-terminal KIP1 PF07765.12 CDF41396.1 - 6.5 7.0 8.2 2.2 8.5 1.6 3.2 3 1 1 4 4 4 0 KIP1-like protein SMC_N PF02463.19 CDF41397.1 - 5.3e-07 29.3 0.2 1.1e-06 28.3 0.2 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CDF41397.1 - 3.3e-05 24.0 0.0 0.00014 22.1 0.0 2.2 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF1687 PF07955.11 CDF41397.1 - 0.044 14.3 0.4 0.2 12.2 0.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) Bacillus_HBL PF05791.11 CDF41397.1 - 0.81 9.5 5.0 6.6 6.5 0.6 3.1 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) ABC_tran PF00005.27 CDF41397.1 - 4.6 7.7 10.6 5.2 7.6 2.8 3.8 2 2 0 2 2 2 0 ABC transporter DUF87 PF01935.17 CDF41397.1 - 8.4 6.4 19.8 0.28 11.3 1.7 3.6 2 2 1 3 3 3 0 Helicase HerA, central domain AAA_23 PF13476.6 CDF41398.1 - 4.6e-09 37.1 0.0 8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Metallophos_2 PF12850.7 CDF41398.1 - 4.7e-07 30.1 0.0 1.2e-06 28.8 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CDF41398.1 - 2.2e-05 25.1 0.0 3.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Iso_dh PF00180.20 CDF41399.1 - 1.8e-73 247.7 0.0 2e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GHL5 PF14872.6 CDF41400.1 - 0.26 9.3 0.0 0.29 9.1 0.0 1.0 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 Rieske PF00355.26 CDF41402.1 - 5e-15 55.2 0.0 8.5e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 CDF41402.1 - 1.8e-10 40.7 0.0 2.5e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain adh_short_C2 PF13561.6 CDF41404.1 - 4.9e-42 144.1 0.0 5.4e-42 144.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDF41404.1 - 1.1e-39 136.0 0.0 1.3e-39 135.7 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDF41404.1 - 6.2e-05 23.0 0.0 8.3e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CDF41404.1 - 0.0036 16.7 0.0 0.0053 16.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) AAA_12 PF13087.6 CDF41405.1 - 2.7e-59 200.2 0.0 4.4e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDF41405.1 - 3.8e-46 158.0 0.5 1.2e-24 87.5 0.1 2.6 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 CDF41405.1 - 9.8e-14 51.5 0.6 2.3e-12 47.1 0.3 2.6 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDF41405.1 - 2.1e-12 47.6 0.1 4.5e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDF41405.1 - 0.0004 20.1 0.1 0.0061 16.4 0.0 2.4 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 CDF41405.1 - 0.0011 19.3 0.1 1 9.7 0.0 3.2 3 1 0 3 3 3 1 AAA domain PhoH PF02562.16 CDF41405.1 - 0.0017 17.9 0.0 0.51 9.8 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein ResIII PF04851.15 CDF41405.1 - 0.0034 17.4 0.0 0.12 12.3 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDF41405.1 - 0.0038 17.0 0.2 2 8.1 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase DUF2075 PF09848.9 CDF41405.1 - 0.014 14.7 0.2 0.054 12.7 0.2 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 CDF41405.1 - 0.015 14.5 0.2 3.5 6.7 0.1 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA PF00004.29 CDF41405.1 - 0.03 14.7 0.0 0.082 13.3 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDF41405.1 - 0.04 13.5 0.1 0.14 11.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDF41405.1 - 0.055 13.8 0.1 0.14 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Helicase_RecD PF05127.14 CDF41405.1 - 0.11 12.3 0.0 0.44 10.4 0.1 2.1 2 1 0 2 2 2 0 Helicase AAA_33 PF13671.6 CDF41405.1 - 0.11 12.6 0.7 6.8 6.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain Pkinase PF00069.25 CDF41409.1 - 1.1e-05 25.0 0.0 1.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF41409.1 - 0.018 14.3 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.14 CDF41409.1 - 0.079 12.3 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HtrL_YibB PF09612.10 CDF41411.1 - 8.8e-09 35.3 0.6 1.9e-08 34.2 0.6 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) Glycos_transf_2 PF00535.26 CDF41411.1 - 0.0012 18.7 0.0 0.0028 17.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Galactosyl_T PF01762.21 CDF41412.1 - 3.2e-21 76.1 1.9 9.9e-20 71.2 1.0 2.6 2 1 0 2 2 2 1 Galactosyltransferase HIRA_B PF09453.10 CDF41413.1 - 0.11 12.4 1.4 0.18 11.7 1.4 1.3 1 0 0 1 1 1 0 HIRA B motif Pro_isomerase PF00160.21 CDF41415.1 - 4.6e-15 56.2 0.0 5.5e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Multi_Drug_Res PF00893.19 CDF41416.1 - 5.2e-27 94.4 7.0 6.4e-27 94.1 7.0 1.1 1 0 0 1 1 1 1 Small Multidrug Resistance protein Glyoxalase_4 PF13669.6 CDF41417.1 - 1.5e-17 63.8 0.1 1.2e-16 60.9 0.0 1.9 1 1 1 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 CDF41417.1 - 2.5e-15 56.8 0.1 2.9e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDF41417.1 - 4.1e-05 24.3 0.1 5.2e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CDF41417.1 - 5.5e-05 23.4 0.1 0.00083 19.5 0.1 2.0 1 1 0 1 1 1 1 Glyoxalase-like domain COesterase PF00135.28 CDF41418.1 - 3.8e-108 362.6 0.0 4.6e-108 362.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDF41418.1 - 3.1e-11 43.6 0.5 0.00023 21.1 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDF41418.1 - 0.00016 21.3 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family RVT_3 PF13456.6 CDF41419.1 - 0.034 14.0 0.1 0.11 12.3 0.1 1.8 1 1 0 1 1 1 0 Reverse transcriptase-like Plant_tran PF04827.14 CDF41420.1 - 4.3e-41 140.8 0.2 2e-32 112.5 0.1 2.2 1 1 1 2 2 2 2 Plant transposon protein DDE_Tnp_4 PF13359.6 CDF41420.1 - 1.1e-08 34.9 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_tranf_2_3 PF13641.6 CDF41420.1 - 0.054 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF3488 PF11992.8 CDF41421.1 - 0.028 13.4 5.8 0.047 12.6 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) HSP70 PF00012.20 CDF41422.1 - 1.3e-259 862.4 7.3 1.7e-259 862.1 7.3 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDF41422.1 - 2e-11 43.3 1.1 1.2e-10 40.7 0.1 2.5 2 1 0 2 2 2 1 MreB/Mbl protein DUF4624 PF15417.6 CDF41422.1 - 0.031 14.1 0.7 0.11 12.3 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4624) DUF16 PF01519.16 CDF41422.1 - 0.041 14.4 0.1 0.16 12.4 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 PUL PF08324.11 CDF41422.1 - 0.11 11.7 3.4 0.22 10.7 3.4 1.4 1 0 0 1 1 1 0 PUL domain SKA1 PF07160.12 CDF41422.1 - 1.7 8.4 9.0 2.2 8.1 7.8 1.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 ALMT PF11744.8 CDF41422.1 - 5.1 5.8 10.7 11 4.8 10.7 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Fe_bilin_red PF05996.12 CDF41423.1 - 2.3e-66 223.8 1.6 2.9e-66 223.4 1.6 1.1 1 0 0 1 1 1 1 Ferredoxin-dependent bilin reductase DUF1365 PF07103.11 CDF41424.1 - 1.4e-48 165.7 0.0 1.6e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) AAA_16 PF13191.6 CDF41426.1 - 0.0075 16.7 1.0 0.0095 16.3 0.7 1.4 1 1 0 1 1 1 1 AAA ATPase domain UvrD_C PF13361.6 CDF41426.1 - 0.042 13.2 0.0 0.042 13.2 0.0 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF5344 PF17279.2 CDF41426.1 - 0.049 14.2 0.3 0.08 13.5 0.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5344) IPI_T4 PF11634.8 CDF41426.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Nuclease inhibitor from bacteriophage T4 GDE_N PF12439.8 CDF41427.1 - 4.6e-61 206.0 0.1 2.8e-35 121.7 0.0 2.2 2 0 0 2 2 2 2 Glycogen debranching enzyme N terminal GDE_C PF06202.14 CDF41427.1 - 5.7e-20 71.6 0.0 1.2e-19 70.5 0.0 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase EMP24_GP25L PF01105.24 CDF41428.1 - 3.9e-26 92.1 0.0 5.7e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pex24p PF06398.11 CDF41428.1 - 0.017 14.1 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF1492 PF07374.11 CDF41428.1 - 0.042 14.0 0.0 0.068 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) DUF1690 PF07956.11 CDF41428.1 - 0.045 14.2 0.0 0.079 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) ZZ PF00569.17 CDF41429.1 - 1.9e-07 30.8 4.1 3.7e-07 29.9 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 CDF41429.1 - 3.4e-06 27.2 0.1 7.6e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 CDF41429.1 - 6.9e-05 23.1 0.0 0.00016 21.9 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 CDF41429.1 - 0.0017 18.5 0.0 0.0041 17.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DMAP_binding PF06464.11 CDF41429.1 - 0.0047 17.7 0.3 0.0047 17.7 0.3 2.1 2 0 0 2 2 2 1 DMAP1-binding Domain hnRNP_Q_AcD PF18360.1 CDF41430.1 - 1.3e-68 226.9 0.0 1.5e-19 69.7 0.0 4.1 4 0 0 4 4 4 4 Heterogeneous nuclear ribonucleoprotein Q acidic domain HEAT_2 PF13646.6 CDF41430.1 - 0.49 10.8 4.1 14 6.1 0.0 3.9 4 0 0 4 4 4 0 HEAT repeats SPX PF03105.19 CDF41430.1 - 2.1 8.1 7.6 3.7 7.4 7.6 1.4 1 0 0 1 1 1 0 SPX domain Bac_surface_Ag PF01103.23 CDF41431.1 - 1e-06 28.5 0.2 4e-06 26.6 0.1 2.0 2 1 0 2 2 2 1 Surface antigen POTRA_2 PF08479.11 CDF41431.1 - 0.0092 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 POTRA domain, ShlB-type Utp11 PF03998.13 CDF41432.1 - 3.7e-52 177.7 14.6 4.4e-52 177.5 14.6 1.1 1 0 0 1 1 1 1 Utp11 protein DUF749 PF05370.11 CDF41432.1 - 0.16 12.1 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF749) ABC2_membrane PF01061.24 CDF41434.1 - 1.2e-40 139.2 6.9 1.5e-40 138.9 6.9 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CDF41434.1 - 9.3e-11 42.4 0.0 1.8e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CDF41434.1 - 2.3e-08 33.6 0.5 3.6e-08 32.9 0.5 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 CDF41434.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system GDP_Man_Dehyd PF16363.5 CDF41435.1 - 4.5e-54 184.1 0.0 2.3e-48 165.3 0.0 2.1 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDF41435.1 - 2e-53 181.3 0.0 2.5e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDF41435.1 - 1.8e-18 66.7 0.0 2.2e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDF41435.1 - 1.2e-11 44.2 0.0 2.8e-09 36.4 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDF41435.1 - 7.5e-11 41.7 0.0 2.1e-06 27.1 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CDF41435.1 - 1.2e-06 28.0 0.0 4.3e-05 22.8 0.0 2.7 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CDF41435.1 - 9.6e-06 25.6 0.1 4.3e-05 23.5 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CDF41435.1 - 0.00013 21.7 0.1 0.088 12.3 0.2 2.5 2 1 0 2 2 2 2 NmrA-like family KR PF08659.10 CDF41435.1 - 0.028 14.3 0.6 3.9 7.3 0.3 2.3 1 1 1 2 2 2 0 KR domain PIF1 PF05970.14 CDF77379.1 - 8.4e-91 304.8 0.0 1.1e-90 304.5 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.6 CDF77379.1 - 5.6e-06 26.7 0.1 1.3e-05 25.5 0.1 1.7 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.6 CDF77379.1 - 3e-05 23.8 0.0 7.2e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain HrcA PF01628.21 CDF77379.1 - 0.17 11.8 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 HrcA protein C terminal domain Enolase_C PF00113.22 CDF77384.1 - 7.4e-57 192.8 0.0 8.7e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain MR_MLE_C PF13378.6 CDF77384.1 - 0.00082 19.0 0.1 0.014 15.0 0.1 1.9 1 1 0 2 2 2 1 Enolase C-terminal domain-like Cornichon PF03311.14 CDF77387.1 - 1.5e-35 122.2 4.3 1.8e-35 121.9 4.3 1.1 1 0 0 1 1 1 1 Cornichon protein BatA PF07584.11 CDF77387.1 - 3.3 8.2 9.3 0.19 12.1 3.5 2.0 2 1 0 2 2 2 0 Aerotolerance regulator N-terminal Tmemb_14 PF03647.13 CDF77388.1 - 1.6e-17 64.0 12.9 2.5e-17 63.4 12.9 1.3 1 0 0 1 1 1 1 Transmembrane proteins 14C Coq4 PF05019.13 CDF77389.1 - 6.4e-73 244.7 0.0 8.1e-73 244.4 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Thg1 PF04446.12 CDF77390.1 - 1.3e-46 157.7 0.0 1.8e-46 157.2 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 CDF77390.1 - 9.2e-39 132.4 0.0 1.3e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain IcmF-related PF06761.12 CDF77390.1 - 0.038 13.4 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Intracellular multiplication and human macrophage-killing ACOX PF01756.19 CDF77395.1 - 1.3e-16 60.7 0.3 2.1e-16 60.0 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 CDF77395.1 - 6.4e-12 45.5 0.0 1.2e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CDF77395.1 - 3.6e-07 30.5 0.3 8e-07 29.4 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 CDF77395.1 - 9.3e-05 23.0 0.0 0.00018 22.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_N PF02771.16 CDF77395.1 - 0.064 13.9 0.0 0.22 12.2 0.0 1.9 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain ACOX PF01756.19 CDF77396.1 - 1.3e-13 50.9 0.0 2.4e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 CDF77396.1 - 5.7e-13 48.9 0.0 1.1e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CDF77396.1 - 1.1e-07 32.2 0.0 2.2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 CDF77396.1 - 1.4e-06 28.9 0.2 2.8e-06 27.9 0.2 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal GYF_2 PF14237.6 CDF77396.1 - 0.17 11.7 0.1 0.45 10.4 0.1 1.7 1 0 0 1 1 1 0 GYF domain 2 Pro_isomerase PF00160.21 CDF77398.1 - 2.8e-09 37.4 0.0 3.8e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rotamase PF00639.21 CDF77399.1 - 3.8e-19 69.4 0.0 5.9e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CDF77399.1 - 7.1e-18 65.2 0.0 1.2e-17 64.5 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CDF77399.1 - 2.1e-05 25.3 0.0 3.4e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Osmo_CC PF08946.10 CDF77399.1 - 0.43 10.9 1.4 3 8.2 0.1 2.1 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Complex1_49kDa PF00346.19 CDF77400.1 - 1.8e-121 404.4 0.0 2.4e-121 404.0 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CDF77400.1 - 0.015 14.2 0.0 0.03 13.2 0.0 1.5 1 1 0 1 1 1 0 Nickel-dependent hydrogenase Complex1_49kDa PF00346.19 CDF77401.1 - 1.1e-117 391.9 0.0 1.4e-117 391.6 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Catalase PF00199.19 CDF77403.1 - 1.2e-163 544.7 0.0 1.4e-163 544.5 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CDF77403.1 - 1.9e-15 56.8 0.0 4.3e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive SHMT PF00464.19 CDF77406.1 - 5.2e-176 585.1 0.0 6.2e-176 584.8 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase LDcluster4 PF18306.1 CDF77406.1 - 0.021 14.4 0.2 0.06 12.9 0.0 1.7 2 0 0 2 2 2 0 SLOG cluster4 family Aminotran_1_2 PF00155.21 CDF77406.1 - 0.1 11.8 0.0 0.34 10.0 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II DUF948 PF06103.11 CDF77410.1 - 0.00024 21.3 1.0 1.1 9.6 0.2 3.2 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF3584 PF12128.8 CDF77410.1 - 0.00049 17.8 4.3 0.00059 17.5 4.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) GAS PF13851.6 CDF77410.1 - 0.001 18.5 2.8 0.016 14.6 0.2 2.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.22 CDF77410.1 - 0.0023 18.1 0.7 1.9 8.7 0.2 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Baculo_PEP_C PF04513.12 CDF77410.1 - 0.0024 17.9 0.9 0.38 10.8 0.4 2.4 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Taxilin PF09728.9 CDF77410.1 - 0.0024 17.1 0.1 0.0032 16.7 0.1 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein APG17 PF04108.12 CDF77410.1 - 0.0031 16.7 4.4 0.0083 15.3 4.4 1.7 1 1 0 1 1 1 1 Autophagy protein Apg17 AAA_13 PF13166.6 CDF77410.1 - 0.0033 16.2 2.7 0.0048 15.6 2.7 1.2 1 0 0 1 1 1 1 AAA domain EzrA PF06160.12 CDF77410.1 - 0.0056 14.9 0.7 0.0076 14.5 0.7 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Med28 PF11594.8 CDF77410.1 - 0.0056 16.7 0.3 0.0099 16.0 0.3 1.4 1 1 0 1 1 1 1 Mediator complex subunit 28 Spc7 PF08317.11 CDF77410.1 - 0.0074 15.2 4.5 0.013 14.4 4.2 1.5 1 1 1 2 2 2 1 Spc7 kinetochore protein HsbA PF12296.8 CDF77410.1 - 0.0079 16.6 0.5 8.7 6.8 0.2 2.9 2 1 1 3 3 3 0 Hydrophobic surface binding protein A HMMR_N PF15905.5 CDF77410.1 - 0.0085 15.6 2.7 0.011 15.2 2.7 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.12 CDF77410.1 - 0.009 16.0 5.8 0.27 11.3 2.0 2.2 1 1 1 2 2 2 1 Laminin Domain II BST2 PF16716.5 CDF77410.1 - 0.012 16.1 3.0 0.14 12.8 0.2 2.4 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 ABC_tran_CTD PF16326.5 CDF77410.1 - 0.015 15.5 1.1 0.68 10.2 0.2 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain Vps53_N PF04100.12 CDF77410.1 - 0.021 13.8 0.7 0.021 13.8 0.7 1.7 2 0 0 2 2 2 0 Vps53-like, N-terminal AIP3 PF03915.13 CDF77410.1 - 0.032 13.4 2.7 0.041 13.0 2.7 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DUF1664 PF07889.12 CDF77410.1 - 0.043 13.9 2.8 0.16 12.0 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 CDF77410.1 - 0.044 13.6 3.2 0.084 12.7 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Dynactin_p22 PF07426.11 CDF77410.1 - 0.049 13.5 3.7 1.4 8.8 0.3 2.3 1 1 1 2 2 2 0 Dynactin subunit p22 CENP-F_leu_zip PF10473.9 CDF77410.1 - 0.049 13.7 4.8 0.34 10.9 1.2 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 End3 PF12761.7 CDF77410.1 - 0.05 13.8 3.1 0.063 13.5 1.7 1.9 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Jnk-SapK_ap_N PF09744.9 CDF77410.1 - 0.075 13.3 5.6 0.62 10.3 5.4 2.1 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 YkyA PF10368.9 CDF77410.1 - 0.078 12.6 0.5 0.11 12.2 0.5 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF4618 PF15397.6 CDF77410.1 - 0.079 12.4 2.6 0.4 10.1 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) TACC_C PF05010.14 CDF77410.1 - 0.088 12.6 1.3 1 9.1 0.2 2.0 1 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Syntaxin-6_N PF09177.11 CDF77410.1 - 0.088 13.4 2.5 0.73 10.4 2.5 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Nsp1_C PF05064.13 CDF77410.1 - 0.097 12.5 1.1 0.29 10.9 0.1 2.0 1 1 1 2 2 2 0 Nsp1-like C-terminal region DHR10 PF18595.1 CDF77410.1 - 0.11 12.5 5.6 0.43 10.6 0.5 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF2408 PF10303.9 CDF77410.1 - 0.13 12.8 3.3 0.38 11.3 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Cluap1 PF10234.9 CDF77410.1 - 0.13 11.6 3.7 0.16 11.4 3.7 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 V-SNARE_C PF12352.8 CDF77410.1 - 0.14 12.5 1.8 1.4 9.3 0.5 2.4 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus NPV_P10 PF05531.12 CDF77410.1 - 0.16 12.4 0.7 5 7.7 0.0 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 CDF77410.1 - 0.17 12.4 3.3 0.42 11.1 3.3 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Fez1 PF06818.15 CDF77410.1 - 0.24 11.8 5.1 4.2 7.8 5.0 2.0 1 1 1 2 2 2 0 Fez1 Fib_alpha PF08702.10 CDF77410.1 - 0.24 11.6 1.8 1.3 9.2 0.2 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family E2F_CC-MB PF16421.5 CDF77410.1 - 0.25 11.7 0.9 0.38 11.1 0.1 1.7 2 0 0 2 2 1 0 E2F transcription factor CC-MB domain ATG16 PF08614.11 CDF77410.1 - 0.26 11.5 7.1 0.72 10.0 6.1 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF812 PF05667.11 CDF77410.1 - 0.27 10.1 3.7 0.57 9.0 3.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) kleA_kleC PF17383.2 CDF77410.1 - 0.36 11.2 3.4 9.6 6.6 0.1 2.9 2 1 1 3 3 2 0 Uncharacterized KorC regulated protein A Serine_rich PF08824.10 CDF77410.1 - 0.37 10.8 4.7 0.84 9.6 1.0 2.2 1 1 1 2 2 2 0 Serine rich protein interaction domain TMF_TATA_bd PF12325.8 CDF77410.1 - 0.45 10.7 4.8 3.5 7.9 0.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding PIN_8 PF18476.1 CDF77410.1 - 0.57 10.0 2.8 3.6 7.4 1.7 1.9 1 1 1 2 2 2 0 PIN like domain FUSC PF04632.12 CDF77410.1 - 0.88 8.0 4.1 1.5 7.3 4.0 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family H-kinase_dim PF02895.14 CDF77410.1 - 1.1 9.7 5.6 2.6 8.5 1.7 2.9 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain CorA PF01544.18 CDF77410.1 - 1.8 7.8 6.6 0.73 9.1 1.0 2.3 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein ThylakoidFormat PF11264.8 CDF77411.1 - 7.2e-28 97.8 0.0 9.2e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Thylakoid formation protein PFL-like PF02901.15 CDF77411.1 - 0.0016 17.2 2.3 0.0077 14.9 1.5 1.9 2 0 0 2 2 2 1 Pyruvate formate lyase-like Oberon_cc PF16312.5 CDF77411.1 - 0.17 11.9 9.9 0.26 11.2 9.9 1.3 1 0 0 1 1 1 0 Coiled-coil region of Oberon TraI PF07057.11 CDF77411.1 - 0.22 11.6 3.3 0.25 11.5 1.4 1.8 2 0 0 2 2 2 0 DNA helicase TraI APG6_N PF17675.1 CDF77411.1 - 1.2 9.6 9.2 2.2 8.8 9.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Chorismate_synt PF01264.21 CDF77413.1 - 8.4e-136 452.0 2.4 9.6e-136 451.8 2.4 1.0 1 0 0 1 1 1 1 Chorismate synthase SKIP_SNW PF02731.15 CDF77415.1 - 2.1e-64 216.0 2.6 2.1e-64 216.0 2.6 1.6 2 0 0 2 2 2 1 SKIP/SNW domain GCK PF07802.11 CDF77416.1 - 6.9e-07 29.6 0.6 1.5e-06 28.5 0.6 1.5 1 0 0 1 1 1 1 GCK domain MAR_sialic_bdg PF10564.9 CDF77416.1 - 0.095 12.8 0.2 0.18 11.9 0.2 1.4 1 0 0 1 1 1 0 Sialic-acid binding micronemal adhesive repeat CHCH PF06747.13 CDF77416.1 - 0.31 11.2 2.6 0.25 11.5 1.1 1.7 2 0 0 2 2 2 0 CHCH domain ABC_membrane_2 PF06472.15 CDF77417.1 - 1.1e-33 116.8 1.4 2.1e-33 115.9 1.4 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDF77417.1 - 1.3e-16 61.4 0.0 2.2e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 CDF77417.1 - 0.00019 21.2 0.0 0.0016 18.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDF77417.1 - 0.0012 18.5 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDF77417.1 - 0.0019 18.6 0.0 0.0053 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CDF77417.1 - 0.003 17.4 0.0 0.028 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDF77417.1 - 0.021 14.3 0.0 4.1 6.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDF77417.1 - 0.057 13.9 0.0 0.097 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDF77417.1 - 0.087 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 CDF77417.1 - 0.19 11.4 0.1 0.47 10.2 0.1 1.7 1 0 0 1 1 1 0 Cytidylate kinase PIF1 PF05970.14 CDF77418.1 - 2.6e-98 329.6 0.0 4e-98 328.9 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 CDF77418.1 - 9.9e-13 48.2 0.0 1.7e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDF77418.1 - 0.023 15.1 0.0 0.059 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Herpes_Helicase PF02689.14 CDF77418.1 - 0.039 11.9 0.0 0.06 11.3 0.0 1.2 1 0 0 1 1 1 0 Helicase UvrD_C_2 PF13538.6 CDF77418.1 - 0.09 12.6 0.1 0.26 11.2 0.1 1.8 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Chromo PF00385.24 CDF77419.1 - 0.0015 18.4 0.1 0.0018 18.1 0.1 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain NAGLU PF05089.12 CDF77419.1 - 0.0041 16.1 0.3 0.0041 16.1 0.3 1.0 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain WD40 PF00400.32 CDF77420.1 - 3.4e-13 49.8 10.7 0.009 16.8 0.2 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF77420.1 - 7.3e-05 23.0 0.0 0.45 10.8 0.0 3.8 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDF77420.1 - 0.11 12.5 0.5 20 5.3 0.1 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF2957 PF11170.8 CDF77420.1 - 0.12 11.2 0.0 1.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2957) Pkinase PF00069.25 CDF77421.1 - 1.9e-53 181.5 0.0 2.3e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF77421.1 - 3.2e-24 85.6 0.0 4.3e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF77421.1 - 4.5e-06 26.2 0.0 2.6e-05 23.7 0.0 1.9 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 CDF77421.1 - 5.8e-05 22.8 0.1 0.00022 20.9 0.0 1.8 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 CDF77421.1 - 0.0001 21.8 0.1 0.00016 21.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF77421.1 - 0.0034 17.4 0.0 0.035 14.0 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 CDF77421.1 - 0.044 13.4 0.0 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Form_Nir_trans PF01226.17 CDF77423.1 - 4.8e-65 219.2 30.5 5.5e-65 219.0 30.5 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter UBA PF00627.31 CDF77424.1 - 0.0014 18.5 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain Tmemb_14 PF03647.13 CDF77424.1 - 0.028 15.1 0.5 0.095 13.5 0.0 2.1 3 0 0 3 3 3 0 Transmembrane proteins 14C Dus PF01207.17 CDF77425.1 - 7.6e-49 166.5 0.0 1.2e-48 165.8 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) MFS_5 PF05631.14 CDF77426.1 - 1e-105 353.6 6.5 1.4e-105 353.1 6.5 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 CDF77426.1 - 9e-14 51.1 40.4 5.5e-12 45.3 28.9 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily Hira PF07569.11 CDF77427.1 - 0.0055 16.5 0.5 0.0087 15.8 0.5 1.3 1 0 0 1 1 1 1 TUP1-like enhancer of split FAA_hydrolase_N PF09298.11 CDF77427.1 - 0.027 14.7 7.1 0.51 10.6 0.1 3.7 1 1 1 3 3 3 0 Fumarylacetoacetase N-terminal Cactin_mid PF10312.9 CDF77427.1 - 0.04 13.6 2.7 0.097 12.4 1.0 2.1 2 0 0 2 2 2 0 Conserved mid region of cactin Lactococcin PF04369.13 CDF77427.1 - 0.061 13.5 0.3 0.32 11.1 0.0 2.2 2 0 0 2 2 2 0 Lactococcin-like family LacI PF00356.21 CDF77427.1 - 0.071 12.9 0.1 0.44 10.4 0.1 2.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family FIVAR PF07554.13 CDF77427.1 - 1.7 9.5 6.2 38 5.1 4.4 3.1 2 1 0 2 2 2 0 FIVAR domain FAM217 PF15344.6 CDF77428.1 - 0.052 13.5 2.1 0.056 13.4 2.1 1.0 1 0 0 1 1 1 0 FAM217 family HCV_env PF01539.17 CDF77428.1 - 0.12 12.1 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 Sulfotransfer_2 PF03567.14 CDF77429.1 - 4.9e-28 98.7 1.9 8.7e-28 97.9 1.9 1.4 1 0 0 1 1 1 1 Sulfotransferase family Pox_RNA_Pol_22 PF05273.13 CDF77429.1 - 0.046 13.5 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 Poxvirus RNA polymerase 22 kDa subunit Sec5 PF15469.6 CDF77429.1 - 0.16 11.8 0.2 0.25 11.1 0.2 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec5 NAD_binding_10 PF13460.6 CDF77430.1 - 1.5e-19 70.6 0.4 1.9e-19 70.3 0.4 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CDF77430.1 - 1.9e-05 24.3 0.1 3.5e-05 23.4 0.0 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CDF77430.1 - 3.1e-05 23.6 0.3 4e-05 23.3 0.3 1.2 1 0 0 1 1 1 1 NmrA-like family DapB_N PF01113.20 CDF77430.1 - 0.0013 18.8 0.0 0.02 15.0 0.0 2.2 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus PALP PF00291.25 CDF77430.1 - 0.003 17.0 0.2 0.0038 16.7 0.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RmlD_sub_bind PF04321.17 CDF77430.1 - 0.0038 16.4 0.0 0.006 15.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDF77430.1 - 0.013 14.5 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Oxidored_q6 PF01058.22 CDF77430.1 - 0.032 14.1 0.1 0.49 10.2 0.1 2.2 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase, 20 Kd subunit K_oxygenase PF13434.6 CDF77430.1 - 0.12 11.5 0.1 0.82 8.8 0.0 1.9 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) GIY-YIG PF01541.24 CDF77431.1 - 0.041 14.2 0.0 0.069 13.4 0.0 1.3 1 0 0 1 1 1 0 GIY-YIG catalytic domain AAA_2 PF07724.14 CDF77432.1 - 3e-56 190.2 0.0 1.7e-52 178.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDF77432.1 - 6.6e-33 112.7 0.8 6.6e-33 112.7 0.8 2.7 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 CDF77432.1 - 1.9e-26 93.1 0.0 5.7e-14 52.7 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CDF77432.1 - 3e-25 88.1 0.2 1.6e-24 85.8 0.2 2.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CDF77432.1 - 3.2e-17 62.8 0.0 1.4e-10 41.3 0.0 3.6 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDF77432.1 - 4.8e-13 49.9 2.3 1.3e-05 25.7 0.1 3.9 2 2 1 3 3 3 2 AAA ATPase domain Sigma54_activat PF00158.26 CDF77432.1 - 2.6e-10 40.3 0.0 2.4e-06 27.4 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_18 PF13238.6 CDF77432.1 - 5.2e-08 33.5 0.0 0.0034 17.9 0.0 3.1 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CDF77432.1 - 1.9e-07 31.0 0.0 0.02 14.7 0.0 2.9 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 CDF77432.1 - 2.9e-07 30.8 4.0 0.011 16.0 0.0 4.4 3 2 0 3 3 3 2 AAA domain TniB PF05621.11 CDF77432.1 - 6.2e-07 29.0 0.0 0.0062 16.0 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein RuvB_N PF05496.12 CDF77432.1 - 8.2e-07 28.9 0.8 0.63 9.8 0.0 4.3 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CDF77432.1 - 1.1e-06 28.7 0.1 0.13 12.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain ATPase_2 PF01637.18 CDF77432.1 - 9.7e-06 25.7 1.7 2 8.2 0.1 4.2 4 0 0 4 4 3 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CDF77432.1 - 2.9e-05 24.4 0.2 0.097 13.1 0.0 2.9 3 0 0 3 3 2 2 RNA helicase AAA_7 PF12775.7 CDF77432.1 - 2.9e-05 23.7 0.0 0.035 13.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Roc PF08477.13 CDF77432.1 - 5.8e-05 23.3 0.0 0.033 14.4 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 CDF77432.1 - 0.00013 21.4 0.0 1.2 8.4 0.0 3.4 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 CDF77432.1 - 0.00017 21.6 0.5 0.12 12.3 0.0 3.3 3 0 0 3 3 3 1 RsgA GTPase NACHT PF05729.12 CDF77432.1 - 0.00017 21.6 0.0 0.22 11.4 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 CDF77432.1 - 0.00029 21.0 1.7 0.16 12.1 0.0 3.4 4 0 0 4 4 2 1 AAA domain AAA_24 PF13479.6 CDF77432.1 - 0.00041 20.1 0.0 0.87 9.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain Torsin PF06309.11 CDF77432.1 - 0.00041 20.4 0.0 0.0054 16.8 0.0 2.4 2 0 0 2 2 2 1 Torsin AAA_3 PF07726.11 CDF77432.1 - 0.00057 19.7 0.1 0.32 10.8 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CDF77432.1 - 0.0008 18.7 0.1 0.63 9.3 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin ResIII PF04851.15 CDF77432.1 - 0.0015 18.6 0.0 1.5 8.8 0.0 3.8 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit ABC_tran PF00005.27 CDF77432.1 - 0.0015 19.1 0.8 0.19 12.2 0.0 3.4 3 1 0 3 3 3 1 ABC transporter TsaE PF02367.17 CDF77432.1 - 0.0015 18.5 0.0 1.6 8.7 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CDF77432.1 - 0.0018 18.5 2.1 1.1 9.5 0.0 3.9 3 1 0 3 3 3 1 AAA domain AAA_17 PF13207.6 CDF77432.1 - 0.0048 17.3 1.2 1.4 9.3 0.0 3.4 3 0 0 3 3 2 1 AAA domain DNA_pol3_delta2 PF13177.6 CDF77432.1 - 0.0048 16.7 0.0 0.98 9.2 0.0 3.6 3 1 0 3 3 3 1 DNA polymerase III, delta subunit NTPase_1 PF03266.15 CDF77432.1 - 0.0061 16.5 0.1 5.4 6.9 0.0 3.3 3 0 0 3 3 3 0 NTPase PduV-EutP PF10662.9 CDF77432.1 - 0.0066 16.2 0.0 0.087 12.6 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Bac_DnaA PF00308.18 CDF77432.1 - 0.0086 15.9 0.4 0.92 9.3 0.0 3.5 4 0 0 4 4 3 1 Bacterial dnaA protein ATP_bind_1 PF03029.17 CDF77432.1 - 0.017 14.9 0.0 1.2 8.9 0.0 2.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 CDF77432.1 - 0.019 14.5 5.4 0.057 13.0 0.0 3.8 4 0 0 4 4 4 0 AAA domain Clp_N PF02861.20 CDF77432.1 - 0.023 14.8 0.0 0.11 12.7 0.0 2.2 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component SRP54 PF00448.22 CDF77432.1 - 0.035 13.7 0.0 0.98 9.0 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Ras PF00071.22 CDF77432.1 - 0.039 13.5 0.0 15 5.1 0.0 3.9 4 1 1 5 5 4 0 Ras family TIP49 PF06068.13 CDF77432.1 - 0.048 12.9 1.4 3.4 6.8 0.0 2.9 3 0 0 3 3 3 0 TIP49 P-loop domain AAA_19 PF13245.6 CDF77432.1 - 0.071 13.4 1.6 8.3 6.7 1.9 3.4 3 1 0 3 3 2 0 AAA domain AAA_6 PF12774.7 CDF77432.1 - 0.11 11.4 0.1 0.8 8.6 0.0 2.3 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region DUF948 PF06103.11 CDF77432.1 - 0.12 12.6 0.5 3.6 7.9 0.2 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ICA69 PF04629.14 CDF77432.1 - 0.2 11.9 2.4 0.35 11.1 2.4 1.3 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain OEP PF02321.18 CDF77432.1 - 0.33 10.8 7.3 0.81 9.5 7.3 1.6 1 0 0 1 1 1 0 Outer membrane efflux protein Atg14 PF10186.9 CDF77432.1 - 0.45 9.5 6.0 0.85 8.6 6.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 CDF77432.1 - 0.57 9.0 9.6 1.3 7.8 9.6 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein XhlA PF10779.9 CDF77432.1 - 1.2 9.4 7.3 2 8.7 0.8 3.0 1 1 1 2 2 2 0 Haemolysin XhlA Snapin_Pallidin PF14712.6 CDF77432.1 - 3.2 8.2 11.5 1.2 9.6 5.0 3.6 3 1 0 3 3 2 0 Snapin/Pallidin AAA_23 PF13476.6 CDF77432.1 - 4.2 7.8 11.5 3.6e+02 1.5 0.0 3.3 2 1 0 2 2 2 0 AAA domain Prefoldin PF02996.17 CDF77432.1 - 4.4 7.2 9.9 30 4.6 0.0 4.4 4 1 1 5 5 4 0 Prefoldin subunit DUF4407 PF14362.6 CDF77432.1 - 8.3 5.7 10.9 20 4.4 11.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) adh_short PF00106.25 CDF77433.1 - 5.7e-22 78.1 0.0 7.1e-19 68.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDF77433.1 - 1.4e-13 51.0 0.0 9.8e-11 41.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDF77433.1 - 3.6e-06 26.6 0.0 0.0002 20.9 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CDF77433.1 - 4.8e-06 26.6 0.0 7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDF77433.1 - 6.1e-05 23.0 0.2 9.2e-05 22.4 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding S-AdoMet_synt_C PF02773.16 CDF77434.1 - 1.5e-68 229.0 0.3 3.4e-68 227.9 0.0 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDF77434.1 - 1.4e-45 154.4 0.0 2.5e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CDF77434.1 - 1.1e-41 141.6 0.1 2.1e-41 140.6 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain JmjC PF02373.22 CDF77435.1 - 2.6e-31 108.4 0.0 5.1e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase ANTAR PF03861.14 CDF77435.1 - 0.081 12.8 0.2 0.25 11.2 0.2 1.9 1 0 0 1 1 1 0 ANTAR domain zf-C5HC2 PF02928.16 CDF77435.1 - 0.41 11.1 6.2 1.1 9.7 6.2 1.7 1 0 0 1 1 1 0 C5HC2 zinc finger PPR_2 PF13041.6 CDF77436.1 - 3.9e-104 340.7 11.0 2.6e-13 49.9 0.0 14.2 6 4 9 15 15 15 12 PPR repeat family PPR_1 PF12854.7 CDF77436.1 - 2.4e-84 276.7 3.9 1.3e-09 37.5 0.0 15.8 15 1 0 15 15 15 12 PPR repeat PPR_3 PF13812.6 CDF77436.1 - 5.4e-84 276.2 0.1 1.1e-16 60.7 0.0 10.3 6 2 4 11 11 11 9 Pentatricopeptide repeat domain PPR PF01535.20 CDF77436.1 - 5.7e-82 264.4 14.4 1.4e-07 31.3 0.0 18.1 17 2 0 17 17 17 15 PPR repeat PPR_long PF17177.4 CDF77436.1 - 2.4e-52 177.4 2.7 1.1e-16 60.9 0.0 7.0 2 1 5 7 7 7 6 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 CDF77436.1 - 1.2e-08 34.8 0.0 0.89 9.4 0.0 6.2 4 2 3 7 7 7 3 Mitochondrial ATPase expression TPR_14 PF13428.6 CDF77436.1 - 1.6e-07 31.5 13.8 52 5.0 0.0 11.8 11 3 3 14 14 12 0 Tetratricopeptide repeat Ku_PK_bind PF08785.11 CDF77436.1 - 0.0044 17.2 1.8 13 6.0 0.0 4.6 5 1 1 6 6 6 1 Ku C terminal domain like TetR_C_15 PF17918.1 CDF77436.1 - 0.0075 17.0 0.6 0.12 13.1 0.1 3.3 3 0 0 3 3 3 1 Tetracyclin repressor-like, C-terminal domain AP_endonuc_2 PF01261.24 CDF77436.1 - 0.13 11.7 0.1 0.65 9.4 0.0 2.2 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel MRP-S27 PF10037.9 CDF77436.1 - 0.15 10.9 0.0 17 4.1 0.0 2.5 2 1 1 3 3 3 0 Mitochondrial 28S ribosomal protein S27 Wzy_C_2 PF11846.8 CDF77436.1 - 0.45 10.4 3.6 74 3.2 0.1 5.1 6 1 1 7 7 7 0 Virulence factor membrane-bound polymerase, C-terminal TetR_C_11 PF16859.5 CDF77436.1 - 0.51 10.7 9.7 1.5 9.1 0.1 5.3 6 0 0 6 6 6 0 Tetracyclin repressor-like, C-terminal domain Myb_DNA-binding PF00249.31 CDF77437.1 - 5.2e-34 116.2 2.7 5.1e-16 58.6 0.3 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF77437.1 - 9.2e-27 93.1 0.4 5e-15 55.5 0.0 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 CDF77437.1 - 0.036 14.1 0.0 0.58 10.2 0.0 2.6 2 1 1 3 3 3 0 SLIDE Myb_DNA-bind_2 PF08914.11 CDF77437.1 - 0.052 13.7 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 Rap1 Myb domain Rap1_C PF11626.8 CDF77437.1 - 0.057 13.5 0.2 8.1 6.6 0.0 2.6 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_4 PF13837.6 CDF77437.1 - 0.5 10.8 2.4 5.3 7.5 0.4 3.1 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain TGT PF01702.18 CDF77439.1 - 9.4e-144 478.9 0.0 1.1e-143 478.6 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase C2 PF00168.30 CDF77440.1 - 3.3e-07 30.5 0.2 5.7e-05 23.3 0.0 2.4 1 1 1 2 2 2 2 C2 domain FBPase PF00316.20 CDF77441.1 - 2e-66 223.1 0.4 2.9e-66 222.5 0.4 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain ABC_membrane PF00664.23 CDF77442.1 - 2.7e-55 188.0 2.0 3.8e-55 187.5 2.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDF77442.1 - 1.8e-31 109.5 0.0 3.1e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDF77442.1 - 4.2e-06 26.3 0.1 0.00022 20.7 0.3 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 CDF77442.1 - 0.00045 19.9 0.3 0.52 9.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDF77442.1 - 0.00049 20.5 1.9 0.02 15.3 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CDF77442.1 - 0.0053 16.5 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CDF77442.1 - 0.0094 16.5 0.0 0.019 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 CDF77442.1 - 0.048 13.4 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 CDF77442.1 - 0.16 12.2 0.2 1.2 9.4 0.2 2.3 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 CDF77442.1 - 0.28 11.2 0.6 0.54 10.3 0.6 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain Ldh_1_N PF00056.23 CDF77444.1 - 2.2e-31 108.8 0.7 4.9e-31 107.7 0.5 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDF77444.1 - 9.4e-28 97.2 0.0 1.7e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Fez1 PF06818.15 CDF77447.1 - 0.94 9.9 73.1 0.66 10.4 12.8 4.3 2 2 2 4 4 4 0 Fez1 NAPRTase_C PF17956.1 CDF77447.1 - 4 7.9 8.7 0.34 11.4 1.9 2.7 2 1 1 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain BST2 PF16716.5 CDF77449.1 - 0.11 13.1 0.3 0.11 13.1 0.3 2.4 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 GAS PF13851.6 CDF77449.1 - 0.16 11.3 6.8 0.21 10.9 6.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DASH_Spc19 PF08287.11 CDF77449.1 - 2.6 7.9 12.3 0.19 11.6 6.1 1.9 1 1 1 2 2 2 0 Spc19 Apelin PF15360.6 CDF77449.1 - 3.6 8.2 10.0 0.6 10.7 1.4 2.5 2 0 0 2 2 2 0 APJ endogenous ligand Glyco_hydro_47 PF01532.20 CDF77451.1 - 6e-93 312.2 0.0 7.1e-93 312.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4519 PF15012.6 CDF77451.1 - 0.073 13.2 1.0 0.13 12.4 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) 7TMR-DISM_7TM PF07695.11 CDF77452.1 - 0.063 13.2 10.3 0.085 12.7 10.3 1.1 1 0 0 1 1 1 0 7TM diverse intracellular signalling TMEM156 PF15106.6 CDF77452.1 - 0.093 12.2 0.8 0.11 11.9 0.5 1.3 1 1 0 1 1 1 0 TMEM156 protein family HXXEE PF13787.6 CDF77452.1 - 0.62 10.9 9.2 1.3 9.8 9.2 1.6 1 1 0 1 1 1 0 Protein of unknown function with HXXEE motif Wzy_C PF04932.15 CDF77452.1 - 1.1 8.8 7.9 1.5 8.5 7.9 1.2 1 0 0 1 1 1 0 O-Antigen ligase Synaptobrevin PF00957.21 CDF77452.1 - 5.7 6.8 7.3 8.1 6.3 3.7 2.3 2 0 0 2 2 2 0 Synaptobrevin Glyco_transf_7C PF02709.14 CDF77453.1 - 6.7e-05 22.5 0.0 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDF77453.1 - 0.00053 19.5 0.1 0.00083 18.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Rieske PF00355.26 CDF77454.1 - 2.6e-14 52.9 0.0 4.6e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain CytB6-F_Fe-S PF08802.10 CDF77454.1 - 2.8e-11 43.3 0.5 8.6e-11 41.7 0.5 1.9 1 0 0 1 1 1 1 Cytochrome B6-F complex Fe-S subunit WHAMM-JMY_N PF15920.5 CDF77454.1 - 0.024 14.5 0.4 0.041 13.7 0.4 1.3 1 0 0 1 1 1 0 N-terminal of Junction-mediating and WASP homolog-associated Ge1_WD40 PF16529.5 CDF77455.1 - 0.002 17.2 0.0 0.0042 16.1 0.0 1.6 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Ku_PK_bind PF08785.11 CDF77455.1 - 0.0033 17.6 0.2 0.015 15.4 0.1 2.2 2 0 0 2 2 2 1 Ku C terminal domain like WD40 PF00400.32 CDF77455.1 - 1.2 10.1 4.4 4.6 8.3 0.0 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF4795 PF16043.5 CDF77455.1 - 1.3 8.6 5.5 9 5.8 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4795) CPL PF08144.11 CDF77456.1 - 2.1e-13 50.9 0.3 9.1e-11 42.3 0.0 3.8 4 1 1 5 5 5 1 CPL (NUC119) domain PUF PF00806.19 CDF77456.1 - 0.0009 18.8 0.0 17 5.4 0.0 4.9 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat ETF PF01012.21 CDF77458.1 - 6.8e-47 159.7 0.6 8.7e-47 159.3 0.6 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain FKBP_C PF00254.28 CDF77459.1 - 2.3e-18 66.3 0.0 3e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pyr_redox_2 PF07992.14 CDF77461.1 - 1.1e-36 126.5 1.9 2.2e-36 125.6 1.9 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDF77461.1 - 5.8e-16 58.8 0.9 5.2e-12 46.2 0.3 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDF77461.1 - 2.6e-05 24.0 14.6 0.0038 16.9 0.1 4.4 2 2 1 5 5 5 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDF77461.1 - 3.4e-05 23.9 4.5 0.25 11.3 0.0 4.0 2 2 2 4 4 4 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CDF77461.1 - 4.7e-05 23.5 1.7 0.0016 18.6 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CDF77461.1 - 9.3e-05 21.7 0.2 0.00055 19.2 0.1 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CDF77461.1 - 0.00012 21.3 3.2 0.015 14.4 0.2 2.6 2 1 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CDF77461.1 - 0.00015 21.1 0.1 0.085 12.1 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CDF77461.1 - 0.0012 17.8 1.5 0.12 11.2 0.0 2.6 3 0 0 3 3 3 1 Tryptophan halogenase Thi4 PF01946.17 CDF77461.1 - 0.0019 17.5 1.3 0.0055 16.0 0.0 2.2 3 0 0 3 3 3 1 Thi4 family AlaDh_PNT_C PF01262.21 CDF77461.1 - 0.0042 16.4 1.4 0.29 10.4 0.1 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CDF77461.1 - 0.0045 16.1 0.1 0.0045 16.1 0.1 2.6 2 1 0 3 3 3 1 FAD binding domain FAD_binding_3 PF01494.19 CDF77461.1 - 0.0053 16.0 4.5 0.12 11.6 0.4 2.9 3 0 0 3 3 3 1 FAD binding domain ThiF PF00899.21 CDF77461.1 - 0.015 14.6 0.1 0.037 13.4 0.1 1.6 1 0 0 1 1 1 0 ThiF family ApbA PF02558.16 CDF77461.1 - 0.026 14.2 0.4 0.15 11.7 0.2 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 CDF77461.1 - 0.038 14.4 1.0 15 6.1 0.2 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding Transport_MerF PF11431.8 CDF77461.1 - 0.061 13.2 1.9 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Membrane transport protein MerF Sacchrp_dh_NADP PF03435.18 CDF77461.1 - 0.078 13.2 0.6 3 8.1 0.1 2.6 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GIDA PF01134.22 CDF77461.1 - 0.22 10.6 0.0 0.22 10.6 0.0 3.1 3 1 0 4 4 4 0 Glucose inhibited division protein A HI0933_like PF03486.14 CDF77461.1 - 0.46 9.1 5.5 0.44 9.2 0.1 2.8 3 1 0 4 4 4 0 HI0933-like protein Pkinase PF00069.25 CDF77464.1 - 1.4e-63 214.7 0.0 1.9e-63 214.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF77464.1 - 8.4e-29 100.6 0.0 1.4e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDF77464.1 - 2.5e-06 26.7 0.0 3.9e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDF77464.1 - 6.1e-05 22.5 0.0 0.00069 19.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CDF77464.1 - 0.00061 19.8 0.1 0.0055 16.7 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDF77464.1 - 0.001 18.5 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family COQ9 PF08511.11 CDF77465.1 - 0.065 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 COQ9 UPF0253 PF06786.12 CDF77465.1 - 0.08 13.2 0.1 21 5.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0253) DUF2813 PF11398.8 CDF77465.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Myb_DNA-binding PF00249.31 CDF77466.1 - 9.9e-09 35.3 0.1 2.2e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF77466.1 - 0.0034 17.6 0.0 0.0076 16.5 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain eIF2_C PF09173.11 CDF77471.1 - 1.2e-35 121.6 0.1 2.8e-35 120.4 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 CDF77471.1 - 1.9e-23 83.0 1.2 1.6e-22 80.0 1.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDF77471.1 - 6e-11 42.6 0.6 1.5e-10 41.3 0.6 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDF77471.1 - 0.00046 20.2 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDF77471.1 - 0.00052 20.0 0.4 0.0095 15.8 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 CDF77471.1 - 0.031 14.3 0.1 0.072 13.1 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain PfkB PF00294.24 CDF77472.1 - 1.1e-24 87.3 0.4 7.7e-19 68.1 0.0 2.0 2 0 0 2 2 2 2 pfkB family carbohydrate kinase MFS_1 PF07690.16 CDF77473.1 - 4.1e-55 187.1 45.4 4.1e-55 187.1 45.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDF77473.1 - 2.4e-07 30.0 29.6 1.8e-06 27.1 29.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 CDF77473.1 - 0.11 11.0 27.9 0.14 10.7 5.4 3.0 1 1 1 3 3 3 0 MFS/sugar transport protein Myb_DNA-binding PF00249.31 CDF77474.1 - 1.9e-42 143.2 9.9 1.7e-15 56.9 0.1 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDF77474.1 - 6.7e-31 106.3 12.2 2.7e-14 53.1 2.0 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDF77474.1 - 7.3e-06 25.8 0.2 4.3e-05 23.3 0.1 2.2 1 1 1 2 2 2 1 Myb DNA-binding like SLIDE PF09111.10 CDF77474.1 - 0.0045 17.0 0.0 5 7.2 0.0 2.9 2 1 1 3 3 3 2 SLIDE Myb_DNA-bind_4 PF13837.6 CDF77474.1 - 0.057 13.8 0.4 0.057 13.8 0.4 3.2 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain PAP2_3 PF14378.6 CDF77475.1 - 5.8e-14 52.2 15.5 5.8e-14 52.2 15.5 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 CDF77475.1 - 0.00066 19.5 3.0 0.00066 19.5 3.0 1.9 2 0 0 2 2 2 1 PAP2 superfamily BBE PF08031.12 CDF77476.1 - 1.8e-13 50.3 1.3 5e-13 48.9 1.3 1.8 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 CDF77476.1 - 4.4e-07 29.7 0.3 8.2e-07 28.8 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain RdRP_5 PF07925.11 CDF77476.1 - 0.014 12.9 0.0 0.019 12.4 0.0 1.1 1 0 0 1 1 1 0 Reovirus RNA-dependent RNA polymerase lambda 3 UCR_UQCRX_QCR9 PF05365.12 CDF77478.1 - 1.5e-17 63.2 0.1 1.7e-17 63.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Sortilin-Vps10 PF15902.5 CDF77478.1 - 0.014 14.2 0.0 0.015 14.1 0.0 1.0 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, SNF2_N PF00176.23 CDF77479.1 - 1.8e-56 191.4 0.0 3.1e-56 190.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDF77479.1 - 5.9e-06 26.6 0.1 1.4e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 CDF77479.1 - 0.00023 21.4 6.2 0.00023 21.4 6.2 3.3 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 CDF77479.1 - 0.00056 19.9 3.2 0.00056 19.9 3.2 2.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDF77479.1 - 0.00087 19.1 6.8 0.00087 19.1 6.8 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDF77479.1 - 0.0021 18.0 6.3 0.0021 18.0 6.3 3.1 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDF77479.1 - 4.5 7.2 14.3 1.1 9.1 9.2 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDF77479.1 - 6.1 7.1 19.2 1.7 8.9 7.7 2.8 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING GFO_IDH_MocA PF01408.22 CDF77480.1 - 5.7e-19 69.1 0.0 1.5e-18 67.8 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDF77480.1 - 0.00013 21.9 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 CDF77480.1 - 0.002 18.6 0.0 0.0066 17.0 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent G6PD_N PF00479.22 CDF77480.1 - 0.081 13.6 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CDF77480.1 - 0.086 13.1 0.0 0.38 11.0 0.0 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TRIC PF05197.13 CDF77481.1 - 5.2e-10 39.2 0.6 8e-10 38.6 0.6 1.2 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 CDF77481.1 - 0.0037 17.1 0.2 0.0037 17.1 0.2 2.7 2 0 0 2 2 2 1 UPF0126 domain TctB PF07331.11 CDF77481.1 - 0.0066 16.7 3.6 0.0066 16.7 3.6 2.2 1 1 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family DUF4264 PF14084.6 CDF77485.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) UDPG_MGDP_dh_N PF03721.14 CDF77486.1 - 8.5e-60 201.5 0.1 1.4e-59 200.8 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 CDF77486.1 - 1.2e-34 118.9 0.5 2.5e-33 114.6 0.2 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 CDF77486.1 - 2.1e-30 104.7 0.0 4.3e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain zf-HIT PF04438.16 CDF77486.1 - 0.038 13.9 0.5 0.078 12.9 0.5 1.5 1 0 0 1 1 1 0 HIT zinc finger Shikimate_DH PF01488.20 CDF77486.1 - 0.17 12.0 0.9 6 6.9 0.0 3.3 2 2 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase PCRF PF03462.18 CDF77487.1 - 1.2e-47 162.3 0.2 2.8e-47 161.1 0.0 1.7 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CDF77487.1 - 1.3e-33 115.4 0.1 2.3e-33 114.6 0.1 1.4 1 0 0 1 1 1 1 RF-1 domain RILP PF11461.8 CDF77487.1 - 0.039 14.2 0.3 0.094 12.9 0.3 1.6 1 0 0 1 1 1 0 Rab interacting lysosomal protein tRNA-synt_2d PF01409.20 CDF77488.1 - 4.8e-89 298.0 0.0 6.2e-89 297.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Phe_tRNA-synt_N PF02912.18 CDF77488.1 - 2.1e-17 62.8 4.8 2.1e-17 62.8 4.8 2.2 1 1 1 2 2 2 1 Aminoacyl tRNA synthetase class II, N-terminal domain FancD2 PF14631.6 CDF77490.1 - 5.1e-96 322.5 10.2 5.6e-31 107.0 0.8 5.1 4 1 0 4 4 4 4 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 CDF77490.1 - 0.017 15.4 0.3 0.11 12.8 0.1 2.5 2 0 0 2 2 2 0 FANCI solenoid 2 CDC27 PF09507.10 CDF77490.1 - 0.76 9.1 10.4 1.4 8.2 10.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Filament PF00038.21 CDF77491.1 - 0.0071 16.0 2.8 0.011 15.4 2.8 1.2 1 0 0 1 1 1 1 Intermediate filament protein Dynamitin PF04912.14 CDF77491.1 - 0.021 14.1 1.6 0.031 13.6 1.6 1.3 1 0 0 1 1 1 0 Dynamitin CALCOCO1 PF07888.11 CDF77491.1 - 0.028 13.3 4.1 0.037 12.9 4.1 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.9 CDF77491.1 - 0.089 12.8 4.0 0.085 12.9 2.8 1.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran_CTD PF16326.5 CDF77491.1 - 0.099 12.9 5.3 0.16 12.3 0.2 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4140 PF13600.6 CDF77491.1 - 0.11 13.0 3.2 4.7 7.7 0.1 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FlaC_arch PF05377.11 CDF77491.1 - 0.13 12.7 1.3 5.3 7.5 0.0 2.8 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) MatP_C PF17414.2 CDF77491.1 - 0.37 11.0 1.6 0.93 9.7 1.6 1.6 1 0 0 1 1 1 0 MatP C-terminal ribbon-helix-helix domain DUF4201 PF13870.6 CDF77491.1 - 1.1 8.9 5.3 6 6.6 0.2 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 CDF77491.1 - 1.3 7.9 7.5 2.9 6.7 7.5 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Sugarporin_N PF11471.8 CDF77491.1 - 1.3 9.0 16.8 1.4 8.9 3.7 3.5 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension SlyX PF04102.12 CDF77491.1 - 8.5 7.1 8.8 2.2 9.0 2.0 2.9 2 1 1 3 3 3 0 SlyX SNARE_assoc PF09335.11 CDF77492.1 - 5.7e-16 59.1 5.5 5.7e-16 59.1 5.5 1.9 2 0 0 2 2 2 1 SNARE associated Golgi protein RskA PF10099.9 CDF77492.1 - 0.42 10.9 6.0 2.2 8.5 0.8 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TatD_DNase PF01026.21 CDF77498.1 - 4.2e-53 180.3 0.2 4.7e-53 180.2 0.2 1.0 1 0 0 1 1 1 1 TatD related DNase Fungus-induced PF10917.8 CDF77499.1 - 1.6 9.1 3.8 3.2 8.1 3.8 1.6 1 0 0 1 1 1 0 Fungus-induced protein Voltage_CLC PF00654.20 CDF77500.1 - 1.8e-82 277.5 28.8 1.8e-82 277.5 28.8 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CDF77500.1 - 0.002 18.5 0.0 0.1 13.0 0.0 2.7 2 0 0 2 2 2 1 CBS domain DUF5453 PF17534.2 CDF77500.1 - 1.3 9.0 3.5 1.5 8.7 1.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5453) NAS PF03059.16 CDF77505.1 - 2.7e-15 56.5 0.6 3.3e-13 49.6 0.6 3.5 1 1 0 1 1 1 1 Nicotianamine synthase protein a_DG1_N2 PF18424.1 CDF77505.1 - 0.014 15.4 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 0 Alpha-Dystroglycan N-terminal domain 2 Methyltransf_31 PF13847.6 CDF77505.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Spermine_synth PF01564.17 CDF77505.1 - 0.18 11.2 0.0 0.47 9.8 0.0 1.6 1 0 0 1 1 1 0 Spermine/spermidine synthase domain DAGK_cat PF00781.24 CDF77506.1 - 1.5e-23 82.8 0.1 2.4e-23 82.1 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 CDF77506.1 - 0.00053 19.3 0.0 0.00062 19.1 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase PEGA PF08308.11 CDF77506.1 - 0.0039 17.0 0.0 0.0076 16.1 0.0 1.4 1 0 0 1 1 1 1 PEGA domain PALP PF00291.25 CDF77506.1 - 0.0076 15.7 0.2 0.012 15.1 0.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Arg_repressor_C PF02863.18 CDF77506.1 - 0.045 13.6 0.5 0.14 12.1 0.5 1.8 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain RRM_1 PF00076.22 CDF77507.1 - 2.4e-27 94.6 0.0 4.9e-13 48.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 CDF77507.1 - 2.3e-05 24.3 0.0 0.15 12.1 0.0 2.3 2 0 0 2 2 2 2 RNA binding domain RRM_5 PF13893.6 CDF77507.1 - 0.00058 19.5 0.0 0.031 13.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDF77507.1 - 0.22 11.4 0.0 19 5.2 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif Pox_A9 PF04835.12 CDF77508.1 - 0.087 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 A9 protein conserved region Beta_propel PF09826.9 CDF77509.1 - 0.16 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Beta propeller domain Pkinase PF00069.25 CDF77511.1 - 9.8e-10 38.2 0.0 1.8e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF77511.1 - 1.1e-06 28.2 0.0 3.1e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDF77511.1 - 5.8e-06 25.8 0.1 1.3e-05 24.7 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDF77511.1 - 6.5e-05 22.6 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 CDF77511.1 - 0.00031 20.8 0.1 0.00046 20.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDF77511.1 - 0.024 14.2 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Ferric_reduct PF01794.19 CDF77513.1 - 0.014 15.5 0.6 0.016 15.3 0.6 1.1 1 0 0 1 1 1 0 Ferric reductase like transmembrane component IGPD PF00475.18 CDF77516.1 - 6.5e-62 208.1 0.7 1.7e-61 206.7 0.3 1.7 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase Abhydrolase_6 PF12697.7 CDF77517.1 - 0.0008 20.1 0.5 0.0016 19.1 0.2 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Proteasome PF00227.26 CDF77518.1 - 1.2e-19 70.6 0.1 2e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit GHMP_kinases_N PF00288.26 CDF77518.1 - 0.067 13.4 0.2 0.15 12.3 0.2 1.6 1 0 0 1 1 1 0 GHMP kinases N terminal domain Fucokinase PF07959.12 CDF77518.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase Amidohydro_1 PF01979.20 CDF77519.1 - 4.1e-22 79.0 0.0 1e-20 74.4 0.0 2.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDF77519.1 - 5.1e-09 36.1 0.2 0.00073 19.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family DSHCT PF08148.12 CDF77523.1 - 1.9e-28 99.2 0.0 4.3e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CDF77523.1 - 7e-16 58.5 0.0 1.6e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDF77523.1 - 9.5e-10 38.7 0.0 1.9e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDF77523.1 - 1.6e-05 25.2 0.0 3.6e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.6 CDF77524.1 - 1.2e-10 41.6 5.9 0.0033 17.8 0.2 4.4 3 1 1 4 4 4 4 HEAT repeats HEAT PF02985.22 CDF77524.1 - 4.5e-05 23.4 9.3 3.8 8.0 0.0 5.8 6 0 0 6 6 6 3 HEAT repeat DUF2332 PF10094.9 CDF77524.1 - 0.037 13.5 3.5 0.64 9.4 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2332) RICTOR_N PF14664.6 CDF77524.1 - 0.067 12.2 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term NT5C PF06941.12 CDF77525.1 - 5.2e-21 75.3 0.1 8.3e-21 74.7 0.1 1.2 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) WD40 PF00400.32 CDF77525.1 - 3.3e-11 43.5 3.7 0.039 14.8 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF77525.1 - 8.4e-06 26.0 0.0 0.12 12.7 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF77525.1 - 0.00036 19.6 0.0 0.41 9.6 0.0 2.5 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 CDF77526.1 - 3.8e-15 56.0 3.5 0.0036 18.1 0.2 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF77526.1 - 6.6e-06 26.3 0.0 4.4e-05 23.7 0.0 2.4 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDF77526.1 - 0.087 11.8 0.0 0.91 8.4 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MFS_1_like PF12832.7 CDF77527.1 - 0.0066 15.4 1.0 0.0066 15.4 1.0 2.1 2 0 0 2 2 2 1 MFS_1 like family Zip PF02535.22 CDF77527.1 - 0.0067 15.7 2.1 0.41 9.8 0.4 2.7 2 0 0 2 2 2 2 ZIP Zinc transporter Helicase_C PF00271.31 CDF77528.1 - 5.1e-15 55.8 0.0 8.7e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDF77528.1 - 0.1 12.4 0.0 0.28 10.9 0.0 1.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase PH PF00169.29 CDF77529.1 - 1.2e-05 25.7 0.1 3.3e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_2 PF08458.10 CDF77529.1 - 0.0013 19.1 0.0 0.0022 18.3 0.0 1.4 1 0 0 1 1 1 1 Plant pleckstrin homology-like region Syntaxin PF00804.25 CDF77530.1 - 1.4e-19 70.6 3.0 1.4e-19 70.6 3.0 1.5 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 CDF77530.1 - 1.2e-15 57.2 0.5 3.3e-15 55.8 0.5 1.8 1 0 0 1 1 1 1 SNARE domain MCPsignal PF00015.21 CDF77530.1 - 0.0029 17.5 2.7 0.39 10.5 0.1 2.5 2 1 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DASH_Dam1 PF08653.10 CDF77530.1 - 0.025 14.4 0.1 7 6.5 0.0 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 NPV_P10 PF05531.12 CDF77530.1 - 0.042 14.3 2.6 2.5 8.6 0.0 3.2 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4366 PF14283.6 CDF77530.1 - 0.046 13.8 2.1 0.26 11.3 2.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Sec34 PF04136.15 CDF77530.1 - 0.075 12.9 0.6 2.9 7.7 0.0 2.8 2 2 0 2 2 2 0 Sec34-like family SKA1 PF07160.12 CDF77530.1 - 0.16 11.8 6.4 0.68 9.7 1.6 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Fib_alpha PF08702.10 CDF77530.1 - 0.16 12.1 8.5 2 8.6 0.2 3.4 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family CortBP2 PF09727.9 CDF77530.1 - 0.28 11.1 0.1 0.28 11.1 0.1 3.0 2 1 1 3 3 3 0 Cortactin-binding protein-2 YabA PF06156.13 CDF77530.1 - 0.71 10.5 4.3 3.4 8.4 0.1 2.8 1 1 1 2 2 2 0 Initiation control protein YabA DUF16 PF01519.16 CDF77530.1 - 1.3 9.5 7.2 1.3 9.5 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 CDF77530.1 - 1.3 9.4 5.6 4 7.8 0.7 3.2 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG2 PF06148.11 CDF77530.1 - 4.5 7.4 8.2 18 5.4 0.3 2.8 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 FlaC_arch PF05377.11 CDF77530.1 - 7.9 7.0 7.2 28 5.2 0.1 3.6 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) DUF823 PF05689.11 CDF77531.1 - 0.021 14.6 0.1 0.023 14.4 0.1 1.2 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF823) PIF1 PF05970.14 CDF77532.1 - 1.3e-56 192.3 0.0 1.6e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.6 CDF77532.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 CDF77532.1 - 0.011 13.7 0.0 0.016 13.2 0.0 1.1 1 0 0 1 1 1 0 Helicase Helitron_like_N PF14214.6 CDF77533.1 - 7.2e-35 120.9 0.1 1.2e-34 120.2 0.1 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus rve PF00665.26 CDF77534.1 - 1.9e-05 24.8 0.1 8.6e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CDF77534.1 - 0.0034 17.2 0.0 0.0069 16.2 0.0 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_2 PF07727.14 CDF77535.1 - 5.8e-71 238.9 0.0 1.4e-70 237.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF77535.1 - 2.9e-34 117.7 0.6 5.8e-34 116.7 0.6 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF77535.1 - 1.5e-21 76.8 0.0 5.2e-21 75.0 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF77535.1 - 7.6e-07 28.9 0.0 2.8e-06 27.1 0.0 2.0 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF77535.1 - 0.0012 18.5 0.0 0.0036 17.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_6 PF15288.6 CDF77535.1 - 0.16 11.9 2.4 0.5 10.2 2.4 1.8 1 0 0 1 1 1 0 Zinc knuckle Spore_coat_CotO PF14153.6 CDF77535.1 - 0.17 11.8 2.1 0.31 10.9 2.1 1.4 1 0 0 1 1 1 0 Spore coat protein CotO zf-CCHC_4 PF14392.6 CDF77535.1 - 0.55 10.0 2.2 3.4 7.5 2.2 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 CDF77535.1 - 0.95 9.7 3.9 2.2 8.5 3.9 1.6 1 0 0 1 1 1 0 Zinc knuckle RVT_2 PF07727.14 CDF77536.1 - 1.8e-71 240.6 0.0 3.4e-71 239.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF77536.1 - 2.4e-32 111.5 0.0 5.7e-32 110.3 0.0 1.7 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF77536.1 - 6.9e-22 77.9 0.0 2e-21 76.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF77536.1 - 2.7e-05 23.9 0.0 0.00012 21.9 0.0 2.2 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF77536.1 - 0.0035 17.1 0.0 0.0083 15.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain CENP-C_mid PF15620.6 CDF77536.1 - 0.039 13.9 0.4 0.082 12.9 0.4 1.4 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region zf-CCHC_4 PF14392.6 CDF77536.1 - 0.45 10.3 1.8 1.2 8.9 1.8 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF77536.1 - 1.2 9.3 4.1 2.8 8.2 4.1 1.6 1 0 0 1 1 1 0 Zinc knuckle TIP49 PF06068.13 CDF77537.1 - 1.2e-26 93.8 0.0 1.5e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDF77537.1 - 3.2e-10 40.0 0.3 5.4e-10 39.3 0.1 1.5 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CDF77540.1 - 8.9e-16 58.5 0.0 1.4e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 CDF77540.1 - 2.8e-15 56.5 0.0 6.9e-15 55.2 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 CDF77540.1 - 1.4e-12 47.7 0.0 8.5e-09 35.4 0.0 2.6 2 1 1 3 3 3 2 DNA polymerase III, delta subunit Rad17 PF03215.15 CDF77540.1 - 1.1e-07 32.0 0.0 2.5e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 CDF77540.1 - 0.00017 21.4 0.0 0.00033 20.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDF77540.1 - 0.0003 21.1 0.4 0.51 10.6 0.2 2.6 2 1 1 3 3 2 2 AAA domain AAA_7 PF12775.7 CDF77540.1 - 0.00038 20.0 0.0 0.00068 19.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 CDF77540.1 - 0.0005 19.9 0.1 0.002 18.0 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CDF77540.1 - 0.00054 20.4 0.0 0.01 16.2 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDF77540.1 - 0.0008 19.2 0.1 0.0017 18.1 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CDF77540.1 - 0.0015 18.6 0.0 0.003 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 CDF77540.1 - 0.0021 18.3 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain DEAD PF00270.29 CDF77540.1 - 0.0024 17.6 0.1 0.048 13.4 0.0 2.3 1 1 0 2 2 2 1 DEAD/DEAH box helicase TniB PF05621.11 CDF77540.1 - 0.0045 16.4 0.0 0.18 11.2 0.0 2.2 1 1 1 2 2 2 1 Bacterial TniB protein AAA_5 PF07728.14 CDF77540.1 - 0.0089 16.0 0.6 0.083 12.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CDF77540.1 - 0.0095 15.7 0.1 0.076 12.7 0.0 2.2 2 1 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.6 CDF77540.1 - 0.014 15.7 0.1 0.071 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDF77540.1 - 0.022 13.9 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ResIII PF04851.15 CDF77540.1 - 0.033 14.2 0.0 0.11 12.4 0.0 1.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit TIP49 PF06068.13 CDF77540.1 - 0.074 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain DNA_pol3_delta PF06144.13 CDF77540.1 - 0.08 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_24 PF13479.6 CDF77540.1 - 0.086 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain BrkDBD PF09607.10 CDF77540.1 - 0.089 12.6 0.1 4.7 7.1 0.0 2.6 2 0 0 2 2 2 0 Brinker DNA-binding domain PhoH PF02562.16 CDF77540.1 - 0.098 12.1 0.0 2.7 7.4 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.6 CDF77540.1 - 0.12 12.9 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CDF77540.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PHD_4 PF16866.5 CDF77541.1 - 0.00033 20.7 6.4 0.014 15.4 3.7 2.4 2 0 0 2 2 2 1 PHD-finger Vps36-NZF-N PF16988.5 CDF77541.1 - 0.0015 17.9 0.4 0.0029 17.0 0.4 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Lar_restr_allev PF14354.6 CDF77541.1 - 0.041 14.3 3.3 0.041 14.3 3.3 1.8 2 0 0 2 2 2 0 Restriction alleviation protein Lar GIY-YIG PF01541.24 CDF77541.1 - 0.2 12.0 0.0 0.37 11.1 0.0 1.4 1 0 0 1 1 1 0 GIY-YIG catalytic domain PHD PF00628.29 CDF77541.1 - 0.3 11.0 10.8 1.1 9.1 9.3 2.4 1 1 0 1 1 1 0 PHD-finger zinc_ribbon_9 PF14369.6 CDF77541.1 - 0.61 10.4 8.1 0.24 11.7 1.1 3.1 2 1 1 3 3 3 0 zinc-ribbon C1_1 PF00130.22 CDF77541.1 - 0.64 9.9 6.9 0.96 9.4 3.9 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RRN7 PF11781.8 CDF77541.1 - 0.9 9.3 4.6 2 8.2 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Prok-RING_1 PF14446.6 CDF77541.1 - 1.3 9.1 9.8 4.1 7.4 6.6 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 CDF77541.1 - 8.3 6.1 13.0 6.5 6.5 7.5 3.0 2 1 1 3 3 3 0 Zinc-ribbon, C4HC2 type OrfB_Zn_ribbon PF07282.11 CDF77541.1 - 8.7 6.4 8.9 3.6 7.6 5.9 1.8 1 1 1 2 2 2 0 Putative transposase DNA-binding domain DUF3837 PF12939.7 CDF77543.1 - 0.066 13.6 0.1 0.1 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) NOP5NT PF08156.13 CDF77543.1 - 0.13 12.7 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 NOP5NT (NUC127) domain DUF3301 PF11743.8 CDF77543.1 - 0.18 11.5 0.1 5.9 6.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) RepA_C PF04796.12 CDF77544.1 - 0.034 14.2 0.1 0.044 13.8 0.1 1.2 1 0 0 1 1 1 0 Plasmid encoded RepA protein MMR_HSR1 PF01926.23 CDF77545.1 - 1e-13 51.4 0.0 1.3e-12 47.8 0.0 2.6 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDF77545.1 - 0.0004 19.9 0.0 0.0023 17.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDF77545.1 - 0.0021 17.7 0.0 0.48 9.9 0.1 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDF77545.1 - 0.0066 16.5 0.1 0.015 15.3 0.1 1.6 1 0 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 CDF77545.1 - 0.016 15.1 0.0 0.31 10.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase efThoc1 PF11957.8 CDF77546.1 - 4.1e-31 108.2 0.0 1.5e-18 66.8 0.0 2.6 1 1 1 2 2 2 2 THO complex subunit 1 transcription elongation factor Peptidase_M91 PF14891.6 CDF77546.1 - 0.026 14.9 2.4 0.049 14.0 2.4 1.5 1 0 0 1 1 1 0 Effector protein SPC22 PF04573.12 CDF77548.1 - 3.8e-45 153.4 0.1 4.2e-45 153.3 0.1 1.0 1 0 0 1 1 1 1 Signal peptidase subunit F-box-like PF12937.7 CDF77549.1 - 2.7e-11 43.2 0.1 8.7e-11 41.5 0.0 2.0 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 CDF77549.1 - 2.3e-06 27.3 0.0 1.1e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 F-box domain SPOC PF07744.13 CDF77549.1 - 3.9e-06 26.8 0.0 6.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 SPOC domain DUF3788 PF12663.7 CDF77549.1 - 0.093 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) DNA_pol_A PF00476.20 CDF77550.1 - 1.2e-107 360.3 0.0 1.8e-107 359.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 CDF77550.1 - 9.2e-39 132.9 0.1 9.2e-39 132.9 0.1 1.9 3 0 0 3 3 3 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 CDF77550.1 - 1.6e-18 67.1 0.0 5.3e-18 65.4 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Ribonucleas_3_3 PF14622.6 CDF77550.1 - 0.0033 17.6 0.0 0.0069 16.5 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease-III-like HHH_5 PF14520.6 CDF77550.1 - 0.012 16.3 0.0 0.039 14.6 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.7 CDF77550.1 - 0.027 14.5 0.0 0.075 13.1 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Patched PF02460.18 CDF77551.1 - 7.4e-63 212.9 3.1 9e-63 212.6 3.1 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDF77551.1 - 2.8e-35 121.4 14.6 2.2e-32 112.0 1.0 2.9 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CDF77551.1 - 2.2e-06 26.8 18.0 0.0036 16.3 5.4 2.3 2 0 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 CDF77551.1 - 0.0022 17.4 5.6 0.0022 17.4 5.6 2.2 2 0 0 2 2 2 1 Protein export membrane protein RVT_2 PF07727.14 CDF77556.1 - 1.2e-70 237.9 0.0 2.1e-70 237.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CDF77556.1 - 2.2e-32 111.6 0.0 5e-32 110.4 0.0 1.7 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDF77556.1 - 6.9e-22 77.9 0.0 2e-21 76.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDF77556.1 - 2.7e-05 23.9 0.0 0.00012 21.9 0.0 2.2 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CDF77556.1 - 0.0035 17.1 0.0 0.0083 15.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain CENP-C_mid PF15620.6 CDF77556.1 - 0.039 13.9 0.4 0.082 12.9 0.4 1.4 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region zf-CCHC_4 PF14392.6 CDF77556.1 - 0.43 10.3 1.8 1.2 8.9 1.8 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDF77556.1 - 1.2 9.3 4.1 2.8 8.2 4.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Iso_dh PF00180.20 CDF77557.1 - 3e-96 322.6 0.0 3.4e-96 322.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Na_H_Exchanger PF00999.21 CDF77558.1 - 3e-46 157.9 46.3 2.8e-29 102.1 19.7 2.1 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family EF-hand_1 PF00036.32 CDF77558.1 - 0.00018 20.8 0.0 0.00051 19.4 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDF77558.1 - 0.00026 20.7 0.4 0.002 17.9 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 CDF77558.1 - 0.012 16.0 0.1 0.064 13.7 0.5 1.9 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.6 CDF77558.1 - 0.013 15.3 0.1 0.039 13.8 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 CDF77558.1 - 0.11 12.0 0.1 0.46 10.1 0.1 2.0 2 0 0 2 2 2 0 EF hand UPF0182 PF03699.13 CDF77558.1 - 0.23 9.5 6.2 0.41 8.7 6.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Oxidored_q6 PF01058.22 CDF77559.1 - 9.8e-22 77.2 0.1 1.5e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DUF2448 PF10476.9 CDF77559.1 - 0.071 13.0 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Ubie_methyltran PF01209.18 CDF77561.1 - 1.7e-78 263.2 0.0 2.1e-78 262.9 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CDF77561.1 - 1.2e-19 70.8 0.0 3e-19 69.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDF77561.1 - 1.3e-18 67.4 0.0 4.6e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDF77561.1 - 1.1e-15 57.8 0.0 1.9e-15 56.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDF77561.1 - 8e-09 35.5 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDF77561.1 - 1.6e-07 32.0 0.0 2.5e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CDF77561.1 - 0.0086 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 CDF77561.1 - 0.059 12.9 0.0 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain RBFA PF02033.18 CDF77562.1 - 7.7e-05 23.1 0.0 0.00012 22.5 0.0 1.3 1 0 0 1 1 1 1 Ribosome-binding factor A BTG PF07742.12 CDF77562.1 - 0.085 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 BTG family Spc7 PF08317.11 CDF77563.1 - 0.029 13.3 0.3 0.04 12.8 0.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TRAF_BIRC3_bd PF16673.5 CDF77563.1 - 0.1 12.4 0.3 0.19 11.6 0.3 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain T2SSJ PF11612.8 CDF77563.1 - 0.14 12.4 0.3 17 5.6 0.0 2.1 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein J RT_RNaseH PF17917.1 CDF77564.1 - 1.1e-35 122.1 0.0 1.9e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDF77564.1 - 2.4e-33 114.1 0.0 4.1e-33 113.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDF77564.1 - 7e-12 45.3 0.0 1.4e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDF77564.1 - 2.2e-11 44.0 0.0 4.9e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDF77564.1 - 0.0032 17.2 0.3 0.11 12.3 0.0 2.7 2 1 1 3 3 3 1 Integrase core domain Cys_Met_Meta_PP PF01053.20 CDF77567.1 - 1.6e-118 395.6 0.0 1.9e-118 395.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DNA_primase_S PF01896.19 CDF77570.1 - 7.3e-49 166.2 0.0 1e-48 165.7 0.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit CENP-T_C PF15511.6 CDF77571.1 - 1.3e-08 34.9 0.1 1.6e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDF77571.1 - 0.001 19.4 0.1 0.0017 18.7 0.1 1.5 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 CDF77571.1 - 0.0012 19.2 0.2 0.0015 18.9 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDF77571.1 - 0.002 18.4 0.1 0.003 17.8 0.0 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDF77571.1 - 0.0033 17.5 0.2 0.0046 17.1 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 CDF77571.1 - 0.023 14.7 0.0 0.027 14.5 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CDF77571.1 - 0.082 12.9 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated MFS_1 PF07690.16 CDF77572.1 - 4.7e-49 167.2 29.8 4.7e-49 167.2 29.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDF77572.1 - 1.7e-07 30.5 12.9 1.7e-07 30.5 12.9 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter HD_3 PF13023.6 CDF77573.1 - 1.4e-42 145.4 0.6 1.8e-42 145.1 0.6 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CDF77573.1 - 9.3e-11 41.8 0.3 1.9e-10 40.8 0.3 1.5 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 CDF77573.1 - 8.3e-05 22.8 0.5 0.00015 21.9 0.5 1.5 1 0 0 1 1 1 1 HD domain WD40 PF00400.32 CDF77576.1 - 1.4e-35 120.6 14.7 5.6e-08 33.3 0.1 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDF77576.1 - 4.6e-14 52.5 0.3 0.00096 19.4 0.0 5.5 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDF77576.1 - 1.5e-06 28.2 0.0 9.1e-05 22.4 0.0 2.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 CDF77576.1 - 0.0012 17.7 0.6 0.35 9.6 0.3 2.9 2 1 0 3 3 3 2 Nup133 N terminal like Nup160 PF11715.8 CDF77576.1 - 0.0015 17.3 0.7 0.0077 14.9 0.7 1.9 1 1 0 1 1 1 1 Nucleoporin Nup120/160 WD40_like PF17005.5 CDF77576.1 - 0.0055 16.1 0.1 0.017 14.4 0.1 1.9 2 1 0 2 2 2 1 WD40-like domain SGL PF08450.12 CDF77576.1 - 0.015 14.9 0.1 0.09 12.3 0.1 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region LOR PF04525.12 CDF77576.1 - 0.061 12.9 0.1 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 LURP-one-related DUF1145 PF06611.12 CDF77578.1 - 0.18 11.8 0.0 0.19 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1145) SLAC1 PF03595.17 CDF77579.1 - 0.0036 16.6 1.6 0.0036 16.6 1.6 1.4 2 0 0 2 2 2 1 Voltage-dependent anion channel HEAT_EZ PF13513.6 CDF77580.1 - 6.6e-18 64.8 7.1 3.4e-09 37.0 0.0 6.8 5 1 2 7 7 7 4 HEAT-like repeat HEAT PF02985.22 CDF77580.1 - 2.7e-17 61.4 7.3 0.0012 18.9 0.0 6.2 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 CDF77580.1 - 8.9e-10 38.8 2.5 0.088 13.2 0.0 4.3 2 2 1 3 3 3 3 HEAT repeats Arm PF00514.23 CDF77580.1 - 5.6e-05 23.0 1.0 1.1 9.4 0.0 4.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CDF77580.1 - 0.0055 16.8 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDF77580.1 - 0.012 16.2 0.0 0.15 12.7 0.0 2.9 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region Ecm29 PF13001.7 CDF77580.1 - 0.022 13.4 0.0 2.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Proteasome stabiliser DNA_alkylation PF08713.11 CDF77580.1 - 0.054 13.2 0.0 4.7 6.9 0.0 2.2 1 1 1 2 2 2 0 DNA alkylation repair enzyme DUF3437 PF11919.8 CDF77580.1 - 0.07 13.1 0.0 11 6.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Pkinase PF00069.25 CDF77582.1 - 7.4e-35 120.6 0.0 9.6e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF77582.1 - 2.5e-15 56.5 0.0 3.3e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF77582.1 - 0.0013 18.1 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDF77582.1 - 0.0015 17.4 0.0 0.002 17.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDF77582.1 - 0.0043 16.7 0.0 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 CDF77582.1 - 0.013 14.9 0.0 0.031 13.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDF77582.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BCNT PF07572.12 CDF77583.1 - 4.2e-12 46.0 3.5 4.2e-12 46.0 3.5 1.5 2 0 0 2 2 2 1 Bucentaur or craniofacial development EPL1 PF10513.9 CDF77585.1 - 0.0074 16.7 0.1 0.013 15.9 0.1 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like Erythro-docking PF09277.11 CDF77585.1 - 0.054 13.4 0.1 0.32 10.9 0.1 2.3 1 0 0 1 1 1 0 Erythronolide synthase, docking DUF3206 PF11472.8 CDF77585.1 - 0.097 12.7 0.4 7.9 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3206) Sua5_yciO_yrdC PF01300.18 CDF77586.1 - 2.2e-50 170.6 0.0 3.8e-50 169.9 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 CDF77586.1 - 3.6e-27 95.6 0.0 5.3e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding RETICULATA-like PF11891.8 CDF77588.1 - 2.4e-44 151.3 0.0 3.4e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Protein RETICULATA-related Lipoxygenase PF00305.19 CDF77589.1 - 9.3e-45 153.2 0.0 2.6e-43 148.5 0.0 2.1 1 1 0 1 1 1 1 Lipoxygenase TFA2_Winged_2 PF18121.1 CDF77589.1 - 0.021 14.5 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Pkinase PF00069.25 CDF77590.1 - 1.5e-36 126.1 0.7 1.3e-35 123.1 0.7 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF77590.1 - 1.1e-16 60.9 2.3 3.6e-16 59.2 2.3 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CDF77590.1 - 0.0046 16.6 0.8 0.035 13.7 0.3 2.0 1 1 1 2 2 2 1 RIO1 family FTA2 PF13095.6 CDF77590.1 - 0.013 15.1 0.2 0.66 9.6 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDF77590.1 - 0.016 14.5 0.2 0.024 14.0 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDF77590.1 - 0.021 14.1 1.9 0.076 12.3 0.7 2.3 1 1 0 2 2 2 0 Kinase-like Pox_ser-thr_kin PF05445.11 CDF77590.1 - 0.026 13.5 0.1 0.029 13.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EPTP PF03736.17 CDF77590.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 EPTP domain Velvet PF11754.8 CDF77591.1 - 0.002 18.1 0.5 0.0026 17.7 0.5 1.4 1 0 0 1 1 1 1 Velvet factor NFACT-R_1 PF05670.13 CDF77592.1 - 4.9e-16 59.3 0.0 5.8e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-R_2 PF18297.1 CDF77592.1 - 0.0037 17.4 0.0 0.0049 17.0 0.0 1.3 1 0 0 1 1 1 1 NFACT protein RNA binding domain Pkinase PF00069.25 CDF77593.1 - 5.7e-64 216.0 0.0 9.9e-64 215.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDF77593.1 - 1.2e-38 132.9 0.0 2.1e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDF77593.1 - 0.00026 20.4 0.0 0.0017 17.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 CDF77593.1 - 0.0022 17.7 0.1 0.018 14.7 0.1 2.3 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 CDF77593.1 - 0.015 15.3 0.0 0.015 15.3 0.0 2.6 3 1 0 3 3 3 0 Phosphotransferase enzyme family Ral PF11058.8 CDF77593.1 - 0.028 14.0 0.4 0.26 10.9 0.1 2.3 2 0 0 2 2 2 0 Antirestriction protein Ral V_ATPase_I PF01496.19 CDF77593.1 - 4.7 5.0 8.4 4.1 5.2 7.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family PseudoU_synth_2 PF00849.22 CDF77595.1 - 6e-27 94.7 0.0 8.1e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase An_peroxidase PF03098.15 CDF77596.1 - 5.6e-133 444.3 0.0 6.3e-133 444.1 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase CUE PF02845.16 CDF77596.1 - 0.19 11.5 0.0 0.43 10.3 0.0 1.5 1 0 0 1 1 1 0 CUE domain An_peroxidase PF03098.15 CDF77598.1 - 2.8e-118 395.8 0.0 3.2e-118 395.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Xpo1 PF08389.12 CDF77599.1 - 1.3e-20 74.0 1.5 2.9e-20 72.9 0.1 2.5 3 0 0 3 3 3 1 Exportin 1-like protein DUF885 PF05960.11 CDF77599.1 - 0.024 14.3 0.1 0.041 13.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) zf-CCCH_4 PF18044.1 CDF77602.1 - 0.023 14.5 0.8 0.037 13.8 0.8 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger AvrPto PF11592.8 CDF77603.1 - 0.058 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Central core of the bacterial effector protein AvrPto bZIP_1 PF00170.21 CDF77605.1 - 4.6 7.4 16.4 12 6.1 16.4 1.7 1 0 0 1 1 1 0 bZIP transcription factor Nop25 PF09805.9 CDF77607.1 - 8.8e-10 39.2 12.5 8.8e-10 39.2 12.5 2.2 1 1 1 2 2 2 1 Nucleolar protein 12 (25kDa) Slu7 PF11708.8 CDF77607.1 - 0.043 13.6 9.1 0.025 14.3 7.6 1.4 1 1 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Presenilin PF01080.17 CDF77607.1 - 0.23 10.2 1.9 0.26 10.0 1.9 1.2 1 0 0 1 1 1 0 Presenilin DNA_pol_B PF00136.21 CDF77608.1 - 9.7e-95 317.9 0.0 1.3e-94 317.6 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDF77608.1 - 3e-13 49.6 0.0 6.9e-13 48.4 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CDF77608.1 - 0.00057 20.3 4.8 0.00057 20.3 4.8 2.0 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DnaB_bind PF10410.9 CDF77608.1 - 0.083 13.1 0.1 0.29 11.4 0.0 1.9 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Rhodophyta/Chondrus_crispus-ASM35022v2/GCA_000350225.2_ASM35022v2_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Rhodophyta/Chondrus_crispus-ASM35022v2/GCA_000350225.2_ASM35022v2_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Rhodophyta/Chondrus_crispus-ASM35022v2/GCA_000350225.2_ASM35022v2_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Rhodophyta/Chondrus_crispus-ASM35022v2/GCA_000350225.2_ASM35022v2_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 10:49:54 2019 # [ok]