# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Peptidase_C48 PF02902.19 ADC31705.1 - 1.6e-10 41.2 4.5 6.4e-10 39.2 4.4 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain FAM117 PF15388.6 ADC31706.1 - 0.06 12.8 0.0 0.061 12.8 0.0 1.0 1 0 0 1 1 1 0 Protein Family FAM117 Integrase_H2C2 PF17921.1 ADC31707.1 - 1.4e-07 31.5 1.3 6.8e-07 29.3 0.2 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 ADC31707.1 - 0.0011 19.2 0.9 0.0031 17.7 0.9 1.9 1 0 0 1 1 1 1 H2C2 zinc finger Soc PF16855.5 ADC31707.1 - 0.023 15.2 0.1 1.4 9.5 0.1 3.1 2 0 0 2 2 2 0 Small outer capsid protein Integrase_H2C2 PF17921.1 ADC31708.1 - 0.014 15.5 0.4 0.052 13.7 0.4 2.0 1 0 0 1 1 1 0 Integrase zinc binding domain YsaB PF13983.6 ADC31709.1 - 0.012 15.9 0.5 0.057 13.7 0.2 2.3 2 0 0 2 2 2 0 YsaB-like lipoprotein Spc42p PF11544.8 ADC31709.1 - 0.037 14.0 0.1 0.19 11.7 0.1 2.2 1 0 0 1 1 1 0 Spindle pole body component Spc42p AGS_C PF18134.1 ADC31709.1 - 0.052 13.5 3.1 0.38 10.7 0.7 2.8 2 0 0 2 2 2 0 Adenylyl/Guanylyl and SMODS C-terminal sensor domain RPA43_OB PF17875.1 ADC31709.1 - 0.71 10.5 5.2 5.2 7.7 0.9 3.1 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I FAM176 PF14851.6 ADC31709.1 - 2.5 7.8 16.7 0.023 14.3 8.0 2.0 2 0 0 2 2 2 0 FAM176 family CobT PF06213.12 ADC31709.1 - 3 7.2 9.2 5.5 6.3 9.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 ADC31709.1 - 4.3 6.6 18.3 1.9 7.7 12.7 2.9 2 0 0 2 2 2 0 NOA36 protein Mito_fiss_reg PF05308.11 ADC31712.1 - 0.0058 16.7 2.4 0.0066 16.6 2.4 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator PRIMA1 PF16101.5 ADC31712.1 - 0.11 12.6 3.8 0.16 12.0 3.8 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 ADC31712.1 - 2.8 7.3 7.1 2.8 7.3 6.7 1.4 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SRI PF08236.11 ADC31713.1 - 0.023 14.9 2.4 0.065 13.4 0.3 2.1 1 1 1 2 2 2 0 SRI (Set2 Rpb1 interacting) domain Sigma54_AID PF00309.20 ADC31713.1 - 0.057 13.3 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) DUF761 PF05553.11 ADC31713.1 - 0.23 11.0 0.3 0.23 11.0 0.3 1.9 2 0 0 2 2 2 0 Cotton fibre expressed protein TryThrA_C PF12319.8 ADC31714.1 - 0.069 12.6 0.1 0.069 12.6 0.1 2.4 3 0 0 3 3 3 0 Tryptophan-Threonine-rich plasmodium antigen C terminal AA_permease PF00324.21 EFA74503.1 - 1.1e-17 63.8 27.0 1.3e-17 63.5 27.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFA74503.1 - 5e-15 55.3 31.7 5.7e-15 55.1 31.7 1.0 1 0 0 1 1 1 1 Amino acid permease LUC7 PF03194.15 EFA74505.1 - 3.2e-60 203.9 24.5 5.1e-33 114.8 12.0 2.4 2 1 1 3 3 3 2 LUC7 N_terminus RAG1_imp_bd PF12560.8 EFA74505.1 - 0.069 12.7 2.2 0.15 11.6 2.2 1.6 1 0 0 1 1 1 0 RAG1 importin binding zf-RING_2 PF13639.6 EFA74505.1 - 0.26 11.7 1.6 0.4 11.1 0.2 2.0 2 0 0 2 2 2 0 Ring finger domain Fz PF01392.22 EFA74506.1 - 1.8e-05 25.3 1.9 1.8e-05 25.3 1.9 2.2 3 0 0 3 3 3 1 Fz domain DUF3128 PF11326.8 EFA74509.1 - 7.3e-16 58.3 2.0 2.1e-15 56.8 0.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) RNA_pol_L_2 PF13656.6 EFA74510.1 - 4.6e-29 100.0 0.0 5.9e-29 99.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFA74510.1 - 1.9e-12 46.4 0.0 2.8e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain HHH_6 PF14579.6 EFA74510.1 - 0.0089 16.3 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif TPR_17 PF13431.6 EFA74512.1 - 6.7e-87 279.8 6.2 1.7e-10 40.5 0.0 9.0 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA74512.1 - 1.4e-09 37.4 17.1 0.19 11.4 0.2 8.1 8 0 0 8 8 8 3 TPR repeat MatP PF06303.12 EFA74512.1 - 4.2e-06 27.2 1.4 11 6.6 0.0 5.7 1 1 5 6 6 6 2 MatP N-terminal domain NleF_casp_inhib PF16809.5 EFA74512.1 - 0.00012 22.1 3.9 3.4 7.6 0.0 6.2 6 1 2 8 8 8 1 NleF caspase inhibitor Glyco_hydro_61 PF03443.14 EFA74512.1 - 0.00012 22.1 2.2 15 5.4 0.0 5.7 5 1 1 6 6 6 1 Glycosyl hydrolase family 61 Lyx_isomer PF07385.12 EFA74512.1 - 0.0022 17.3 2.6 47 3.1 0.0 5.6 2 2 4 6 6 6 0 D-lyxose isomerase DUF1153 PF06627.11 EFA74512.1 - 0.0023 18.0 0.1 5.6 7.2 0.0 5.6 7 1 1 8 8 8 1 Protein of unknown function (DUF1153) Anth_Ig PF05587.13 EFA74512.1 - 0.0055 17.0 9.5 40 4.6 0.0 6.5 8 0 0 8 8 8 0 Anthrax receptor extracellular domain DUF3324 PF11797.8 EFA74512.1 - 0.0089 16.0 4.4 20 5.1 0.1 4.7 2 2 1 4 4 4 0 Protein of unknown function C-terminal (DUF3324) DUF3431 PF11913.8 EFA74512.1 - 0.046 13.5 1.3 7.3 6.3 0.0 3.4 1 1 0 3 3 3 0 Protein of unknown function (DUF3431) Ntox46 PF15538.6 EFA74512.1 - 0.068 13.1 0.4 70 3.4 0.0 4.3 2 2 4 6 6 6 0 Bacterial toxin 46 RRM_1 PF00076.22 EFA74513.1 - 2.4e-12 46.5 0.1 5.1e-07 29.4 0.1 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SSP160 PF06933.11 EFA74513.1 - 0.3 9.2 16.6 0.47 8.6 16.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PEHE PF15275.6 EFA74514.1 - 0.0026 18.4 1.2 0.0026 18.4 1.2 9.1 5 3 2 7 7 7 2 PEHE domain SH2_2 PF14633.6 EFA74515.1 - 1e-59 201.6 0.8 1e-59 201.6 0.8 2.7 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 EFA74515.1 - 2.7e-21 75.8 0.1 5.8e-21 74.8 0.1 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EFA74515.1 - 1e-19 70.8 0.0 2.5e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 EFA74515.1 - 1e-14 54.9 1.8 3.4e-14 53.3 1.8 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SH2 PF00017.24 EFA74515.1 - 2.4e-05 24.3 0.0 0.0011 19.0 0.0 2.9 2 0 0 2 2 2 1 SH2 domain Tex_N PF09371.10 EFA74515.1 - 0.00038 20.2 1.6 0.25 11.0 0.0 3.0 3 0 0 3 3 3 2 Tex-like protein N-terminal domain HHH_9 PF17674.1 EFA74515.1 - 0.0022 18.8 1.7 0.0022 18.8 1.7 2.9 2 1 0 2 2 2 1 HHH domain HHH_3 PF12836.7 EFA74515.1 - 0.11 12.7 0.1 0.28 11.5 0.1 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif GST_N PF02798.20 EFA74516.1 - 3.2e-12 46.6 0.0 8.6e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA74516.1 - 2.8e-10 40.5 0.0 5.3e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA74516.1 - 3.1e-09 37.0 0.0 5.9e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA74516.1 - 7.3e-05 22.9 0.0 0.00012 22.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA74516.1 - 0.00013 22.2 0.0 0.00026 21.1 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA74516.1 - 0.00034 20.6 0.0 0.00093 19.2 0.0 1.6 1 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFA74516.1 - 0.093 13.5 0.0 0.17 12.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain NFACT-R_1 PF05670.13 EFA74518.1 - 4.4e-34 117.4 5.9 1.8e-33 115.5 0.1 3.7 4 0 0 4 4 4 1 NFACT protein RNA binding domain FbpA PF05833.11 EFA74518.1 - 5.1e-31 107.9 19.0 5.1e-31 107.9 19.0 3.7 4 0 0 4 4 4 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 EFA74518.1 - 1.2e-25 89.5 0.0 1.2e-25 89.5 0.0 4.8 4 2 0 4 4 4 1 NFACT protein C-terminal domain DUF5590 PF17881.1 EFA74518.1 - 0.042 13.9 0.1 1.4 9.1 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5590) Mucin PF01456.17 EFA74518.1 - 8.7 6.3 18.0 9 6.3 6.7 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein CBS PF00571.28 EFA74519.1 - 6.6e-14 52.1 4.6 0.001 19.5 0.0 5.5 6 0 0 6 6 6 4 CBS domain LSM PF01423.22 EFA74520.1 - 4.1e-18 64.8 0.3 5.1e-18 64.5 0.3 1.1 1 0 0 1 1 1 1 LSM domain RRM_1 PF00076.22 EFA74521.1 - 1.2e-23 82.7 4.6 1.6e-08 34.2 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec63 PF02889.16 EFA74523.1 - 5.5e-164 543.5 3.5 2.7e-86 288.9 0.3 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFA74523.1 - 7.5e-44 149.6 0.7 3.3e-23 82.3 0.2 3.7 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EFA74523.1 - 1.5e-35 121.7 3.7 1.2e-34 118.8 0.9 3.4 3 0 0 3 3 3 1 N-terminal helicase PWI domain ResIII PF04851.15 EFA74523.1 - 1.5e-22 80.4 0.0 4.6e-12 46.3 0.0 3.0 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFA74523.1 - 1.8e-14 54.0 0.0 5.8e-07 29.8 0.0 4.0 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 EFA74523.1 - 9.4e-05 22.2 0.0 0.034 13.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFA74523.1 - 0.002 18.4 0.1 0.056 13.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain Ribosomal_L50 PF10501.9 EFA74523.1 - 0.031 14.4 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 Ribosomal subunit 39S RRM_1 PF00076.22 EFA74524.1 - 6.9e-15 54.6 0.0 1.2e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA74524.1 - 1.3e-05 25.3 0.1 0.024 14.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif CTD_bind PF04818.13 EFA74524.1 - 1.4e-05 25.8 0.2 3e-05 24.8 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_occluded PF16842.5 EFA74524.1 - 0.0011 18.8 0.0 0.0066 16.3 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif CTK3 PF12243.8 EFA74524.1 - 0.039 14.0 0.2 0.074 13.0 0.2 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 DUF2052 PF09747.9 EFA74525.1 - 0.0071 16.5 3.4 0.0071 16.5 3.4 2.2 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) AP3D1 PF06375.11 EFA74525.1 - 0.16 12.2 14.4 1.1 9.5 6.7 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 PRP1_N PF06424.12 EFA74525.1 - 0.19 12.1 9.0 5.3 7.4 5.2 2.4 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF3093 PF11292.8 EFA74525.1 - 0.2 11.9 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) bZIP_C PF12498.8 EFA74525.1 - 0.38 11.7 5.9 0.96 10.4 5.9 1.6 1 0 0 1 1 1 0 Basic leucine-zipper C terminal CPSF100_C PF13299.6 EFA74525.1 - 0.5 10.5 9.0 1 9.5 1.3 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S49_N PF08496.10 EFA74525.1 - 1.8 8.6 12.4 0.83 9.7 8.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TERB2 PF15101.6 EFA74525.1 - 2.8 8.0 12.1 0.78 9.8 2.1 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Presenilin PF01080.17 EFA74525.1 - 7.6 5.2 11.2 12 4.5 10.9 1.3 1 1 0 1 1 1 0 Presenilin AAT PF03417.16 EFA74526.1 - 0.0096 15.6 0.0 0.033 13.9 0.0 1.8 2 0 0 2 2 2 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase IF4E PF01652.18 EFA74527.1 - 2.9e-38 131.2 0.2 8.9e-38 129.6 0.2 1.9 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Glutaredoxin PF00462.24 EFA74528.1 - 5e-19 68.3 0.1 8.9e-19 67.5 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin TMEM234 PF10639.9 EFA74528.1 - 4.1e-12 46.1 0.1 8.8e-12 45.1 0.1 1.5 1 0 0 1 1 1 1 Putative transmembrane family 234 Thioredoxin_2 PF13098.6 EFA74528.1 - 0.00043 20.7 0.1 0.00077 19.9 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 EFA74528.1 - 0.00076 19.4 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EFA74528.1 - 0.0044 17.0 0.1 0.0077 16.3 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.14 EFA74528.1 - 0.0054 17.1 0.1 0.0089 16.4 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.6 EFA74528.1 - 0.02 15.0 0.3 5.4 7.1 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin GST_N_3 PF13417.6 EFA74528.1 - 0.14 12.5 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Acatn PF13000.7 EFA74529.1 - 1.6e-41 142.4 24.2 1.4e-18 66.8 0.6 4.1 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 NUDIX PF00293.28 EFA74529.1 - 7.4e-15 55.1 0.1 1.8e-14 53.9 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain WBS28 PF15164.6 EFA74529.1 - 0.068 12.4 0.3 0.15 11.3 0.3 1.5 1 0 0 1 1 1 0 Williams-Beuren syndrome chromosomal region 28 protein homologue TMEM220 PF15071.6 EFA74529.1 - 0.23 12.3 1.7 0.52 11.1 0.4 2.2 2 0 0 2 2 2 0 Transmembrane family 220, helix Macro PF01661.21 EFA74530.1 - 1.9e-31 108.6 0.2 7e-31 106.7 0.1 2.1 2 0 0 2 2 2 1 Macro domain WWE PF02825.20 EFA74530.1 - 2.5e-10 40.8 0.9 2.5e-10 40.8 0.9 3.1 3 0 0 3 3 3 1 WWE domain PARP PF00644.20 EFA74530.1 - 3.1e-08 33.4 4.3 3.1e-08 33.4 4.3 4.0 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain SR-25 PF10500.9 EFA74530.1 - 0.9 9.1 38.5 0.024 14.3 11.9 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein WBS_methylT PF12589.8 EFA74530.1 - 5.7 7.8 6.5 1.7 9.5 0.3 3.2 2 0 0 2 2 2 0 Methyltransferase involved in Williams-Beuren syndrome Macro PF01661.21 EFA74531.1 - 1.8e-31 108.6 0.1 5.4e-31 107.1 0.1 1.9 1 0 0 1 1 1 1 Macro domain PARP PF00644.20 EFA74531.1 - 3.1e-18 66.1 10.6 7e-18 64.9 5.4 4.0 4 1 0 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EFA74531.1 - 8.8e-12 45.4 2.4 3.9e-11 43.4 0.4 3.3 2 0 0 2 2 2 1 WWE domain DUF2102 PF09875.9 EFA74531.1 - 0.039 13.7 0.2 0.75 9.6 0.1 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2102) TMV_coat PF00721.21 EFA74531.1 - 0.17 11.7 5.9 0.68 9.7 0.8 3.3 2 0 0 2 2 2 0 Virus coat protein (TMV like) Amdo_NSP PF12475.8 EFA74531.1 - 0.69 10.0 3.9 0.46 10.6 0.5 2.4 2 0 0 2 2 2 0 Amdovirus non-structural protein SLS PF14611.6 EFA74531.1 - 0.76 9.6 28.6 0.035 13.9 0.7 6.1 6 0 0 6 6 6 0 Mitochondrial inner-membrane-bound regulator MDD_C PF18376.1 EFA74532.1 - 1.6e-69 233.4 0.1 2.4e-69 232.9 0.1 1.3 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EFA74532.1 - 6.5e-06 26.3 4.7 1.4e-05 25.2 4.7 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain T4_deiodinase PF00837.17 EFA74533.1 - 1.3e-26 93.4 0.0 1.6e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase T4_deiodinase PF00837.17 EFA74534.1 - 7.7e-21 74.5 0.0 1e-20 74.1 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase UL16 PF17622.2 EFA74534.1 - 0.033 13.8 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 Viral unique long protein 16 MMR_HSR1 PF01926.23 EFA74535.1 - 2.8e-13 50.0 6.0 6.2e-13 48.8 0.0 3.8 5 0 0 5 5 5 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA74535.1 - 2.3e-06 27.2 0.1 0.0003 20.4 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B cobW PF02492.19 EFA74535.1 - 0.00074 19.2 0.1 0.0049 16.5 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFA74535.1 - 0.011 15.6 13.1 0.051 13.5 0.0 3.3 4 0 0 4 4 4 0 RsgA GTPase Metallophos PF00149.28 EFA74536.1 - 1.2e-06 29.2 0.0 1.6e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.6 EFA74536.1 - 0.00016 21.1 0.0 0.0095 15.3 0.0 2.5 2 1 0 2 2 2 2 Metallophosphoesterase, calcineurin superfamily Metallophos_2 PF12850.7 EFA74536.1 - 0.0023 18.1 0.0 0.0035 17.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain BTB_2 PF02214.22 EFA74537.1 - 1.8e-17 63.4 0.7 4e-17 62.3 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain Pentapeptide PF00805.22 EFA74537.1 - 9.9e-17 60.2 20.0 7.7e-08 31.8 0.6 4.5 3 1 2 5 5 5 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFA74537.1 - 3.4e-11 43.1 17.1 0.00017 21.7 0.5 3.6 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFA74537.1 - 1.2e-10 41.4 10.6 3.7e-05 23.8 3.5 3.7 2 1 2 4 4 4 4 Pentapeptide repeats (9 copies) BTB PF00651.31 EFA74537.1 - 0.0015 18.7 0.0 0.0038 17.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Beta_helix PF13229.6 EFA74538.1 - 9.4e-05 22.3 58.3 0.00057 19.8 23.5 3.9 2 1 2 4 4 4 3 Right handed beta helix region Pentapeptide_4 PF13599.6 EFA74538.1 - 0.0061 16.7 7.6 0.41 10.8 0.1 4.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Orf78 PF06024.12 EFA74538.1 - 0.027 14.8 0.2 0.052 13.8 0.2 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Insulin_TMD PF17870.1 EFA74538.1 - 0.057 13.5 1.5 0.15 12.1 1.5 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF840 PF05801.11 EFA74538.1 - 4.2 7.5 8.7 0.83 9.7 0.5 2.9 2 0 0 2 2 2 0 Lagovirus protein of unknown function (DUF840) Chlam_PMP PF02415.17 EFA74539.1 - 0.0079 16.6 1.2 0.0079 16.6 1.2 8.0 7 1 0 7 7 7 4 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pox_I3 PF04661.12 EFA74539.1 - 0.012 14.8 1.9 0.018 14.2 1.9 1.2 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein Chlam_PMP PF02415.17 EFA74540.1 - 0.0057 17.1 40.9 0.36 11.4 0.4 6.6 6 0 0 6 6 6 4 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SR-25 PF10500.9 EFA74541.1 - 0.089 12.4 4.2 0.1 12.2 4.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 EFA74542.1 - 1.9e-05 24.1 0.1 0.0011 18.4 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74542.1 - 0.03 13.6 0.0 0.043 13.1 0.0 1.3 1 1 0 1 1 1 0 Protein tyrosine kinase NMN_transporter PF04973.12 EFA74543.1 - 0.05 13.6 0.9 0.43 10.5 0.9 1.9 1 1 1 2 2 2 0 Nicotinamide mononucleotide transporter Erf4 PF10256.9 EFA74543.1 - 0.051 13.7 1.6 0.086 12.9 1.6 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DUF2207 PF09972.9 EFA74543.1 - 0.34 9.6 2.2 0.42 9.3 2.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CHIP_TPR_N PF18391.1 EFA74544.1 - 0.0015 19.2 1.5 0.0019 19.0 1.5 1.1 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain Ydc2-catalyt PF09159.10 EFA74544.1 - 0.047 13.4 4.6 0.45 10.2 1.9 2.0 1 1 1 2 2 2 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Chlam_PMP PF02415.17 EFA74547.1 - 7.7 7.2 11.6 0.45 11.1 0.7 3.0 3 0 0 3 3 3 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat PhoLip_ATPase_C PF16212.5 EFA74548.1 - 5.4e-84 281.8 25.5 5.4e-84 281.8 25.5 2.5 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA74548.1 - 1.8e-28 98.0 3.1 6.7e-28 96.2 3.1 2.1 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFA74548.1 - 1.5e-13 50.6 0.0 3.8e-12 46.1 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFA74548.1 - 2.1e-09 37.2 0.0 7.7e-09 35.3 0.0 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFA74548.1 - 6.4e-09 36.4 0.2 0.0033 17.7 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA74548.1 - 0.017 14.9 4.0 0.02 14.6 0.0 2.9 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA74548.1 - 0.17 12.3 0.2 3.4 8.0 0.1 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Malate_synthase PF01274.22 EFA74549.1 - 1.1e-60 205.4 0.0 7.8e-37 126.7 0.0 2.3 1 1 1 2 2 2 2 Malate synthase AstE_AspA PF04952.14 EFA74549.1 - 4.4e-41 140.9 0.0 7.3e-41 140.1 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family FAE1_CUT1_RppA PF08392.12 EFA74550.1 - 1.2e-118 395.7 0.0 1.6e-118 395.3 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.15 EFA74550.1 - 2.9e-10 40.3 0.0 5e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.10 EFA74550.1 - 3.1e-10 40.1 0.0 1.4e-09 38.0 0.0 2.0 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 EFA74550.1 - 0.0099 15.7 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Herpes_UL73 PF03554.13 EFA74550.1 - 0.28 11.2 2.9 8.1 6.5 0.0 3.5 3 0 0 3 3 3 0 UL73 viral envelope glycoprotein AhpC-TSA_2 PF13911.6 EFA74551.1 - 2e-19 69.8 0.0 3.7e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Presenilin PF01080.17 EFA74551.1 - 0.015 14.1 0.4 0.015 14.1 0.4 3.1 2 1 1 3 3 3 0 Presenilin AhpC-TSA PF00578.21 EFA74551.1 - 0.07 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family DUF155 PF02582.14 EFA74552.1 - 0.066 13.3 0.5 0.066 13.3 0.5 2.2 2 0 0 2 2 2 0 Uncharacterised ACR, YagE family COG1723 Pex14_N PF04695.13 EFA74552.1 - 1.9 9.2 11.5 3.4 8.3 7.1 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AJAP1_PANP_C PF15298.6 EFA74552.1 - 3 8.0 20.5 1.3 9.2 17.7 1.7 2 0 0 2 2 2 0 AJAP1/PANP C-terminus p450 PF00067.22 EFA74553.1 - 1.5e-72 244.9 0.0 3e-72 243.9 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 DUF4397 PF14344.6 EFA74554.1 - 7.5e-33 113.9 9.7 3.1e-21 76.4 1.3 9.2 9 2 2 11 11 11 2 Domain of unknown function (DUF4397) Y_Y_Y PF07495.13 EFA74554.1 - 4.8e-06 26.4 14.4 1.1 9.2 0.0 8.8 8 0 0 8 8 8 2 Y_Y_Y domain DUF4493 PF14900.6 EFA74554.1 - 3.4e-05 23.8 20.5 0.018 14.9 3.6 4.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4493) DUF3324 PF11797.8 EFA74554.1 - 0.014 15.3 2.2 13 5.7 0.1 4.2 3 0 0 3 3 3 0 Protein of unknown function C-terminal (DUF3324) SprB PF13573.6 EFA74554.1 - 0.43 10.4 28.7 0.016 15.0 1.2 5.0 4 0 0 4 4 4 0 SprB repeat Y_Y_Y PF07495.13 EFA74555.1 - 2.8e-06 27.2 0.5 0.82 9.7 0.0 4.3 3 0 0 3 3 3 3 Y_Y_Y domain SprB PF13573.6 EFA74555.1 - 0.00065 19.4 7.4 0.0014 18.3 0.5 4.0 3 0 0 3 3 3 1 SprB repeat DUF4493 PF14900.6 EFA74555.1 - 0.0029 17.5 2.3 0.0082 16.0 1.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4493) DUF4397 PF14344.6 EFA74555.1 - 0.01 16.6 0.2 0.01 16.6 0.2 5.1 5 1 1 6 6 6 0 Domain of unknown function (DUF4397) Y_Y_Y PF07495.13 EFA74556.1 - 1.3e-06 28.2 0.3 0.82 9.7 0.0 4.2 3 0 0 3 3 3 3 Y_Y_Y domain SprB PF13573.6 EFA74556.1 - 4.3e-05 23.2 5.8 0.00025 20.7 0.3 3.7 3 0 0 3 3 3 1 SprB repeat DUF4397 PF14344.6 EFA74556.1 - 0.0013 19.5 0.1 0.0013 19.5 0.1 6.1 6 1 1 7 7 7 1 Domain of unknown function (DUF4397) DUF4493 PF14900.6 EFA74556.1 - 0.0018 18.2 2.0 0.008 16.1 1.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4493) DUF4397 PF14344.6 EFA74558.1 - 0.00037 21.2 0.1 0.00037 21.2 0.1 7.2 4 2 4 9 9 9 1 Domain of unknown function (DUF4397) Y_Y_Y PF07495.13 EFA74558.1 - 0.021 14.8 0.1 3.9 7.5 0.0 3.5 2 0 0 2 2 2 0 Y_Y_Y domain DUF2911 PF11138.8 EFA74558.1 - 0.15 11.9 1.7 6.4 6.6 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2911) DUF870 PF05912.11 EFA74558.1 - 0.17 11.9 3.0 0.18 11.8 0.2 2.5 3 0 0 3 3 3 0 Caenorhabditis elegans protein of unknown function (DUF870) Gal_Lectin PF02140.18 EFA74558.1 - 0.3 11.6 2.1 18 5.9 0.8 3.2 2 0 0 2 2 2 0 Galactose binding lectin domain Y_Y_Y PF07495.13 EFA74559.1 - 0.004 17.1 6.0 0.67 9.9 0.3 3.7 4 0 0 4 4 4 2 Y_Y_Y domain DUF4397 PF14344.6 EFA74559.1 - 0.13 13.0 0.0 0.13 13.0 0.0 5.8 5 1 1 6 6 6 0 Domain of unknown function (DUF4397) SprB PF13573.6 EFA74559.1 - 9 6.2 21.2 0.093 12.5 0.6 5.4 4 0 0 4 4 4 0 SprB repeat Agenet PF05641.12 EFA74560.1 - 0.14 12.6 0.3 0.85 10.1 0.1 2.1 2 0 0 2 2 2 0 Agenet domain ATP11 PF06644.11 EFA74562.1 - 1.1e-37 130.3 1.7 1.1e-37 130.3 1.7 2.0 2 0 0 2 2 2 1 ATP11 protein DUF3439 PF11921.8 EFA74562.1 - 4.5 7.3 10.7 0.88 9.5 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) TIG PF01833.24 EFA74563.1 - 2.2e-40 136.6 172.5 2.7e-08 33.8 0.5 19.0 17 3 2 19 19 19 14 IPT/TIG domain EGF_2 PF07974.13 EFA74563.1 - 3.4e-05 24.1 34.9 0.0033 17.8 10.1 2.6 2 0 0 2 2 2 2 EGF-like domain ETRAMP PF09716.10 EFA74563.1 - 0.0044 17.1 0.3 0.01 15.9 0.3 1.6 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) EGF PF00008.27 EFA74563.1 - 0.68 10.3 30.8 1.7 9.1 12.2 2.9 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 EFA74563.1 - 2.2 9.0 24.8 10 6.9 10.1 3.4 2 0 0 2 2 2 0 Human growth factor-like EGF PRCC PF10253.9 EFA74563.1 - 2.6 8.8 6.3 5.2 7.8 6.3 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Laminin_EGF PF00053.24 EFA74563.1 - 2.7 8.2 23.3 4 7.7 8.9 2.7 2 0 0 2 2 2 0 Laminin EGF domain PLAC8 PF04749.17 EFA74565.1 - 1.2e-10 42.2 27.6 2.2e-10 41.4 26.2 2.6 2 1 0 2 2 2 1 PLAC8 family Rap1_C PF11626.8 EFA74565.1 - 0.21 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Pkinase_Tyr PF07714.17 EFA74566.1 - 3.1e-59 200.4 0.0 4.9e-59 199.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA74566.1 - 1.7e-50 171.9 0.0 3.5e-50 170.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EFA74566.1 - 3.5e-12 46.3 0.0 1.5e-11 44.2 0.0 2.1 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 EFA74566.1 - 0.013 15.5 0.0 0.039 13.9 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family ABC1 PF03109.16 EFA74566.1 - 0.071 13.3 0.0 0.31 11.2 0.0 2.0 2 0 0 2 2 2 0 ABC1 family SH2_2 PF14633.6 EFA74566.1 - 0.11 11.9 6.8 0.46 9.8 0.0 2.7 3 0 0 3 3 3 0 SH2 domain SR-25 PF10500.9 EFA74566.1 - 0.24 11.0 10.8 0.43 10.2 10.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase_fungal PF17667.1 EFA74566.1 - 1.1 8.0 7.9 4 6.1 7.9 1.9 1 1 0 1 1 1 0 Fungal protein kinase PPP4R2 PF09184.11 EFA74566.1 - 5.4 6.5 21.3 10 5.6 21.3 1.5 1 0 0 1 1 1 0 PPP4R2 XRN_M PF17846.1 EFA74566.1 - 5.9 5.7 8.5 11 4.9 8.5 1.5 1 0 0 1 1 1 0 Xrn1 helical domain CAF1 PF04857.20 EFA74567.1 - 1.8e-60 204.8 31.4 6.4e-33 114.3 17.0 2.5 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.24 EFA74567.1 - 8.5e-05 22.4 0.3 0.00015 21.5 0.3 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DNA_pol_A_exo1 PF01612.20 EFA74567.1 - 0.0023 17.7 0.9 0.47 10.2 0.1 2.6 2 1 1 3 3 3 2 3'-5' exonuclease zf-CCCH_4 PF18044.1 EFA74567.1 - 0.0091 15.8 1.8 0.015 15.1 1.8 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFA74567.1 - 0.039 14.0 2.4 0.072 13.2 2.4 1.5 1 0 0 1 1 1 0 Zinc finger domain Rtt106_N PF18215.1 EFA74567.1 - 0.047 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain Torus PF16131.5 EFA74567.1 - 0.07 13.8 0.5 0.07 13.8 0.5 3.8 3 1 1 4 4 4 0 Torus domain WD40 PF00400.32 EFA74568.1 - 4.6e-42 141.2 14.8 8.3e-08 32.8 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA74568.1 - 1.5e-15 57.2 0.5 0.00015 21.9 0.1 5.8 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA74568.1 - 1.5e-06 27.4 0.1 0.43 9.5 0.0 3.7 2 2 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFA74568.1 - 7.6e-05 22.7 0.1 0.23 11.3 0.0 3.3 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EFA74568.1 - 0.0011 17.3 0.0 0.47 8.7 0.0 2.3 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 EFA74568.1 - 0.049 12.9 0.4 2.1 7.6 0.0 3.0 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EFA74568.1 - 0.1 11.2 0.5 8.6 4.9 0.0 2.8 2 1 0 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.12 EFA74568.1 - 1.8 8.6 3.9 18 5.4 0.1 3.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat ATP-synt_E PF05680.12 EFA74569.1 - 0.0021 18.4 7.0 0.0027 18.0 7.0 1.2 1 0 0 1 1 1 1 ATP synthase E chain DUF1524 PF07510.11 EFA74569.1 - 0.004 17.0 3.0 0.0049 16.7 3.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) UPF0524 PF15823.5 EFA74569.1 - 0.013 14.9 1.5 0.015 14.7 1.5 1.0 1 0 0 1 1 1 0 UPF0524 of C3orf70 Spt20 PF12090.8 EFA74569.1 - 0.017 14.7 12.6 0.019 14.6 12.6 1.2 1 0 0 1 1 1 0 Spt20 family E_Pc_C PF06752.12 EFA74569.1 - 1.1 9.4 14.0 1.2 9.2 14.0 1.2 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Presenilin PF01080.17 EFA74569.1 - 3 6.5 8.4 3.1 6.5 8.4 1.0 1 0 0 1 1 1 0 Presenilin Androgen_recep PF02166.16 EFA74569.1 - 6.9 5.4 12.3 7.5 5.3 12.3 1.1 1 0 0 1 1 1 0 Androgen receptor F-box_5 PF18511.1 EFA74570.1 - 0.0051 16.3 0.2 0.011 15.3 0.2 1.4 1 0 0 1 1 1 1 F-box InvH PF04741.12 EFA74570.1 - 7.6 6.5 8.1 14 5.6 8.1 1.5 1 0 0 1 1 1 0 InvH outer membrane lipoprotein Mon1 PF03164.14 EFA74573.1 - 2.9e-10 39.8 9.6 2.8e-08 33.3 2.6 2.4 2 1 0 2 2 2 2 Trafficking protein Mon1 PG_binding_1 PF01471.18 EFA74573.1 - 2.5e-06 27.6 0.0 4.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain DUF4834 PF16118.5 EFA74573.1 - 6.3 7.8 12.3 11 7.0 4.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Coiled PF05710.12 EFA74574.1 - 0.00064 20.5 7.7 0.00084 20.1 7.7 1.3 1 1 0 1 1 1 1 Coiled coil Peptidase_M48 PF01435.18 EFA74575.1 - 2.6e-41 141.6 0.0 4.1e-41 140.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.5 EFA74575.1 - 7.8e-41 140.0 20.2 2.5e-40 138.3 15.2 3.2 2 2 1 3 3 3 2 CAAX prenyl protease N-terminal, five membrane helices SprT-like PF10263.9 EFA74575.1 - 0.0038 17.1 0.0 0.0071 16.2 0.0 1.3 1 0 0 1 1 1 1 SprT-like family DUF4538 PF15061.6 EFA74575.1 - 0.28 11.0 3.5 0.21 11.4 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Peptidase_M56 PF05569.11 EFA74575.1 - 4.4 6.4 11.8 0.098 11.8 1.5 2.2 1 1 0 2 2 2 0 BlaR1 peptidase M56 FAD_binding_4 PF01565.23 EFA74576.1 - 1.4e-33 115.5 1.0 1.5e-33 115.5 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain Ank_2 PF12796.7 EFA74577.1 - 2.4e-20 72.9 1.1 2.3e-10 40.9 0.1 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA74577.1 - 3.4e-20 70.0 0.2 2.1e-06 27.6 0.1 6.1 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFA74577.1 - 4.7e-19 67.9 1.4 0.00015 22.0 0.1 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFA74577.1 - 1.8e-18 66.6 0.2 1.3e-09 38.4 0.1 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA74577.1 - 6.9e-13 48.5 0.3 1.4e-06 28.4 0.2 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) TPR_2 PF07719.17 EFA74577.1 - 9.4e-11 41.0 3.2 0.00066 19.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA74577.1 - 7.5e-07 28.9 2.5 0.28 11.5 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA74577.1 - 5.8e-06 26.5 0.3 0.0034 17.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA74577.1 - 7.3e-06 25.6 4.5 3.9e-05 23.3 0.1 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 EFA74577.1 - 0.006 16.6 0.9 0.27 11.3 0.3 2.8 2 1 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_11 PF13414.6 EFA74577.1 - 0.014 15.1 0.8 0.27 11.0 0.1 2.7 3 0 0 3 3 3 0 TPR repeat TPR_16 PF13432.6 EFA74577.1 - 0.021 15.5 2.5 1.3 9.7 0.0 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF2802 PF10975.8 EFA74577.1 - 0.027 14.6 0.4 29 4.9 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) SPO22 PF08631.10 EFA74577.1 - 0.039 13.4 0.4 0.16 11.4 0.4 1.8 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 EFA74577.1 - 0.07 13.6 0.7 0.97 10.0 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA74577.1 - 0.37 10.7 2.5 7.9 6.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Ank_4 PF13637.6 EFA74578.1 - 2.8e-07 30.9 0.8 0.0036 17.8 0.1 1.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74578.1 - 0.00031 21.0 0.1 0.0015 18.8 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EFA74578.1 - 0.0015 19.1 0.0 0.0018 18.8 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Lys-AminoMut_A PF09043.11 EFA74578.1 - 0.036 12.5 0.1 0.038 12.5 0.1 1.0 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit RrnaAD PF00398.20 EFA74579.1 - 2.8e-52 177.4 0.0 5.1e-52 176.6 0.0 1.4 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFA74579.1 - 0.00084 20.0 0.0 0.0019 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA74579.1 - 0.074 13.7 0.0 0.17 12.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EFA74579.1 - 0.084 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 EFA74579.1 - 0.17 11.9 0.9 0.58 10.1 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFA74579.1 - 0.51 11.1 3.5 0.63 10.8 0.0 2.8 3 2 1 4 4 4 0 Methyltransferase domain Sugar_tr PF00083.24 EFA74580.1 - 1e-91 308.1 23.1 1.8e-91 307.3 23.1 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFA74580.1 - 2.7e-23 82.5 42.1 4.1e-13 49.0 14.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFA74580.1 - 1e-05 25.0 0.0 1e-05 25.0 0.0 2.4 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF2070 PF09843.9 EFA74580.1 - 6.2 5.0 12.0 9.7 4.3 12.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Mito_carr PF00153.27 EFA74581.1 - 2e-49 165.4 4.1 5.1e-18 64.8 0.5 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein GNT-I PF03071.15 EFA74582.1 - 1e-11 44.3 2.2 2.4e-11 43.1 2.5 1.5 2 0 0 2 2 2 1 GNT-I family MGAT2 PF05060.14 EFA74582.1 - 0.064 12.3 5.2 0.051 12.6 3.3 1.7 2 0 0 2 2 2 0 N-acetylglucosaminyltransferase II (MGAT2) RabGAP-TBC PF00566.18 EFA74583.1 - 6.3e-45 153.5 2.0 6.3e-45 153.5 2.0 5.8 5 2 0 5 5 5 1 Rab-GTPase-TBC domain DEP PF00610.21 EFA74583.1 - 3.7e-36 123.0 1.3 1.7e-18 66.4 0.1 2.6 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_1 PF00036.32 EFA74583.1 - 1.6e-11 42.9 1.0 0.00016 21.0 0.1 3.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA74583.1 - 1.4e-10 40.2 2.1 0.00028 20.6 0.1 3.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFA74583.1 - 1.5e-09 36.9 1.3 0.0005 19.4 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFA74583.1 - 8.7e-06 26.1 11.4 0.013 15.9 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA74583.1 - 0.0039 17.0 6.8 0.14 12.0 0.3 3.7 3 1 1 4 4 4 2 EF-hand domain pair PMSR PF01625.21 EFA74584.1 - 1.7e-63 213.4 1.9 2e-63 213.2 1.9 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Glu_synthase PF01645.17 EFA74586.1 - 0.076 12.1 0.5 0.078 12.1 0.5 1.0 1 0 0 1 1 1 0 Conserved region in glutamate synthase Elong_Iki1 PF10483.9 EFA74587.1 - 1.1e-13 51.3 15.9 1.8e-06 27.7 0.6 4.2 2 1 1 3 3 3 3 Elongator subunit Iki1 Ribosomal_L30_N PF08079.12 EFA74588.1 - 7.9e-24 83.7 7.4 1.4e-23 82.9 7.4 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EFA74588.1 - 1.6e-22 79.1 1.5 1.6e-22 79.1 1.5 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e E1-E2_ATPase PF00122.20 EFA74589.1 - 1.2e-34 119.4 4.4 5.7e-34 117.2 0.2 2.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFA74589.1 - 5.6e-17 62.7 0.0 2.3e-10 41.1 0.0 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 EFA74589.1 - 3.8e-11 43.2 0.1 1.5e-10 41.3 0.1 2.0 1 0 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase_N PF00690.26 EFA74589.1 - 2.3e-05 24.0 0.0 5.2e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFA74589.1 - 0.0014 18.7 0.0 0.0044 17.1 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) SUIM_assoc PF16619.5 EFA74589.1 - 0.21 11.7 3.2 0.44 10.6 3.2 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 AAA_33 PF13671.6 EFA74590.1 - 2.8e-17 63.2 0.0 5.8e-15 55.7 0.0 2.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EFA74590.1 - 6.5e-05 22.5 2.2 0.11 11.9 0.0 2.6 2 1 0 3 3 3 2 Chromatin associated protein KTI12 6PF2K PF01591.18 EFA74590.1 - 0.0066 15.8 4.0 0.074 12.3 0.0 2.9 2 1 1 3 3 3 2 6-phosphofructo-2-kinase AAA_18 PF13238.6 EFA74590.1 - 0.14 12.7 0.0 1.2 9.6 0.0 2.5 1 1 1 2 2 2 0 AAA domain fn3 PF00041.21 EFA74591.1 - 4.6e-17 62.1 32.3 0.0022 18.3 0.1 9.8 10 1 0 10 10 10 5 Fibronectin type III domain EGF_2 PF07974.13 EFA74591.1 - 0.00031 21.1 14.6 0.00097 19.5 14.6 1.9 1 0 0 1 1 1 1 EGF-like domain PapD_C PF02753.17 EFA74591.1 - 0.0021 18.4 3.7 1.1 9.6 0.2 3.4 2 0 0 2 2 2 2 Pili assembly chaperone PapD, C-terminal domain HtaA PF04213.13 EFA74591.1 - 0.02 15.4 0.2 12 6.4 0.0 4.4 4 0 0 4 4 4 0 Htaa DUF2001 PF09393.10 EFA74591.1 - 0.04 13.9 0.1 5.9 6.9 0.0 2.6 2 0 0 2 2 2 0 Phage tail tube protein Laminin_EGF PF00053.24 EFA74591.1 - 0.049 13.8 9.5 0.17 12.0 9.5 2.0 1 0 0 1 1 1 0 Laminin EGF domain Pur_ac_phosph_N PF16656.5 EFA74591.1 - 0.069 13.7 24.4 0.55 10.8 0.2 6.7 5 2 1 6 6 6 0 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 EFA74591.1 - 0.13 12.6 5.8 0.55 10.6 0.3 4.2 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III hEGF PF12661.7 EFA74591.1 - 1.1 10.0 15.0 0.049 14.3 8.4 2.4 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFA74591.1 - 4 7.8 12.3 0.79 10.1 7.5 2.4 2 0 0 2 2 2 0 EGF-like domain DUF4057 PF13266.6 EFA74593.1 - 0.017 14.8 0.1 0.021 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4057) NADH_u_ox_C PF12853.7 EFA74593.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.4 2 1 1 3 3 3 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit DUF4337 PF14235.6 EFA74593.1 - 0.29 11.2 1.7 0.42 10.7 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4848 PF16140.5 EFA74593.1 - 5.1 6.6 10.2 4.4 6.8 0.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4848) Carboxyl_trans PF01039.22 EFA74594.1 - 1.3e-190 634.3 0.2 1.3e-190 634.3 0.2 1.9 2 0 0 2 2 2 1 Carboxyl transferase domain Methyltransf_23 PF13489.6 EFA74594.1 - 6.2e-28 97.7 0.1 1.1e-27 96.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA74594.1 - 1.1e-06 29.3 0.5 8.6e-05 23.2 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA74594.1 - 0.003 18.2 0.0 0.014 16.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA74594.1 - 0.048 14.4 0.2 0.22 12.3 0.2 2.2 1 1 0 1 1 1 0 Methyltransferase domain zf-Mss51 PF13824.6 EFA74594.1 - 0.068 13.3 2.8 0.18 11.9 2.8 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Methyltransf_31 PF13847.6 EFA74594.1 - 0.1 12.4 3.8 0.43 10.4 2.7 2.4 2 1 0 2 2 2 0 Methyltransferase domain DUF3371 PF11851.8 EFA74594.1 - 0.31 12.2 5.9 10 7.2 4.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) AAA_17 PF13207.6 EFA74595.1 - 8.9e-05 22.9 1.2 0.0036 17.7 1.2 2.3 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFA74595.1 - 0.00052 19.8 0.5 0.0064 16.2 0.1 2.6 1 1 0 2 2 2 1 Cytidylate kinase AAA_18 PF13238.6 EFA74595.1 - 0.0047 17.5 6.6 0.0053 17.3 2.2 2.6 1 1 1 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 EFA74595.1 - 0.013 15.6 4.4 0.33 11.1 0.1 2.4 2 1 0 2 2 2 0 Cytidylate kinase-like family HTH_24 PF13412.6 EFA74595.1 - 4.2 7.0 5.9 38 4.0 0.2 3.3 3 1 1 4 4 4 0 Winged helix-turn-helix DNA-binding Chordopox_L2 PF05803.12 EFA74596.1 - 0.21 11.5 3.5 0.14 12.0 0.5 2.2 3 0 0 3 3 3 0 Chordopoxvirus L2 protein DUF3430 PF11912.8 EFA74597.1 - 5.1e-17 62.6 22.8 6.1e-17 62.4 22.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) DUF543 PF04418.12 EFA74597.1 - 0.071 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF543) Gly_transf_sug PF04488.15 EFA74599.1 - 3.9 8.2 7.9 2.7 8.7 0.4 3.3 2 1 1 3 3 3 0 Glycosyltransferase sugar-binding region containing DXD motif LXG PF04740.12 EFA74601.1 - 0.057 13.1 0.1 0.071 12.8 0.1 1.1 1 0 0 1 1 1 0 LXG domain of WXG superfamily TBPIP_N PF15517.6 EFA74602.1 - 0.0012 18.8 0.1 0.0023 17.9 0.1 1.4 1 0 0 1 1 1 1 TBP-interacting protein N-terminus Ribonuclease_3 PF00636.26 EFA74602.1 - 0.017 15.7 0.0 0.027 15.1 0.0 1.4 1 1 0 1 1 1 0 Ribonuclease III domain DUF424 PF04242.13 EFA74602.1 - 0.022 15.0 0.1 0.043 14.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF424) Mistic PF11458.8 EFA74602.1 - 0.037 14.0 0.1 0.075 13.0 0.1 1.6 1 0 0 1 1 1 0 Membrane-integrating protein Mistic DUF4413 PF14372.6 EFA74602.1 - 0.073 13.4 0.6 0.23 11.8 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) TAF PF02969.17 EFA74603.1 - 9.5e-30 102.6 0.2 1.7e-29 101.8 0.2 1.4 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 EFA74603.1 - 0.00087 19.4 0.1 0.015 15.3 0.0 2.2 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EFA74603.1 - 0.0042 17.4 0.4 0.0042 17.4 0.4 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFA74603.1 - 0.024 14.9 0.2 0.044 14.1 0.2 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EFA74603.1 - 0.032 14.3 0.0 0.33 11.0 0.0 2.4 2 1 1 3 3 3 0 Bromodomain associated CENP-S PF15630.6 EFA74603.1 - 0.096 13.1 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 CENP-S protein TrbI_Ftype PF09677.10 EFA74604.1 - 9.1 6.7 7.7 3.1 8.1 1.5 3.3 3 0 0 3 3 3 0 Type-F conjugative transfer system protein (TrbI_Ftype) 2Fe-2S_thioredx PF01257.19 EFA74605.1 - 2e-58 196.4 0.1 2.8e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin FNIP PF05725.12 EFA74606.1 - 2.6e-52 174.7 39.6 3e-14 52.9 2.8 7.8 6 3 1 7 7 7 6 FNIP Repeat Pkinase PF00069.25 EFA74606.1 - 6.5e-29 101.1 2.5 4.8e-28 98.2 2.5 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74606.1 - 3.4e-11 42.9 0.0 1.5e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Homeobox_KN PF05920.11 EFA74607.1 - 9e-09 35.1 0.1 3.1e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFA74607.1 - 2.7e-07 30.3 0.6 1.3e-06 28.2 0.1 2.4 2 1 0 2 2 2 1 Homeodomain AAA PF00004.29 EFA74608.1 - 9.8e-49 165.2 1.0 4.3e-39 134.0 0.0 3.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA74608.1 - 1.9e-19 69.1 0.1 3.9e-10 39.4 0.0 2.4 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFA74608.1 - 1.6e-07 31.9 0.1 2.5e-06 28.0 0.0 2.8 3 0 0 3 3 2 1 AAA ATPase domain TIP49 PF06068.13 EFA74608.1 - 4.1e-06 26.2 0.0 0.00014 21.2 0.0 2.4 2 0 0 2 2 2 1 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 EFA74608.1 - 6.7e-05 23.0 0.0 0.36 10.9 0.0 3.5 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_14 PF13173.6 EFA74608.1 - 8.8e-05 22.5 0.2 0.00045 20.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFA74608.1 - 0.00055 19.7 0.0 0.011 15.5 0.0 2.9 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFA74608.1 - 0.00065 19.7 0.3 0.012 15.6 0.0 3.1 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EFA74608.1 - 0.0013 19.1 0.1 0.011 16.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 EFA74608.1 - 0.0019 18.5 2.2 0.069 13.4 0.1 3.4 3 2 0 4 4 4 1 AAA domain TsaE PF02367.17 EFA74608.1 - 0.0041 17.1 1.1 0.03 14.3 0.1 2.5 2 1 1 3 3 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EFA74608.1 - 0.0042 17.6 0.0 0.0042 17.6 0.0 3.3 3 1 1 4 4 4 1 ABC transporter DUF815 PF05673.13 EFA74608.1 - 0.0053 16.0 0.0 0.014 14.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 EFA74608.1 - 0.011 15.8 1.9 0.032 14.4 0.0 2.7 3 1 0 3 3 2 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EFA74608.1 - 0.017 15.3 0.0 0.14 12.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFA74608.1 - 0.026 14.4 0.1 0.11 12.4 0.1 2.1 1 0 0 1 1 1 0 NACHT domain Rad17 PF03215.15 EFA74608.1 - 0.032 14.2 10.7 0.23 11.4 0.0 3.6 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_7 PF12775.7 EFA74608.1 - 0.035 13.6 0.1 0.11 12.1 0.1 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFA74608.1 - 0.05 13.3 0.0 0.59 9.8 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EFA74608.1 - 0.079 12.7 0.0 0.31 10.8 0.0 2.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EFA74608.1 - 0.19 12.3 6.9 1.3 9.6 0.0 3.8 3 1 1 4 4 4 0 AAA domain TSCPD PF12637.7 EFA74608.1 - 0.45 10.8 2.8 2.9 8.2 0.1 3.0 3 0 0 3 3 2 0 TSCPD domain Abhydrolase_1 PF00561.20 EFA74609.1 - 9.1e-35 120.5 0.0 1.5e-34 119.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA74609.1 - 9.1e-12 44.7 0.0 7.2e-11 41.8 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA74609.1 - 2.2e-07 31.7 0.0 3.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EFA74609.1 - 0.0076 16.3 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Peptidase_S28 PF05577.12 EFA74609.1 - 0.017 13.9 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EFA74609.1 - 0.06 12.8 0.0 3.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFA74609.1 - 0.15 11.6 0.0 3.4 7.2 0.0 2.3 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) HD PF01966.22 EFA74610.1 - 2.7e-14 53.4 2.0 6.9e-14 52.1 0.1 2.3 2 0 0 2 2 2 1 HD domain PDEase_I PF00233.19 EFA74610.1 - 0.0019 18.0 0.7 0.0055 16.4 0.1 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase DUF4484 PF14831.6 EFA74610.1 - 0.043 13.9 1.5 3.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) DUF4538 PF15061.6 EFA74610.1 - 0.3 10.9 2.2 0.29 10.9 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) HJURP_C PF12347.8 EFA74610.1 - 0.59 10.2 4.3 0.12 12.4 0.8 1.7 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat ABC_membrane PF00664.23 EFA74611.1 - 1.1e-58 199.1 19.8 1.8e-58 198.4 19.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFA74611.1 - 4.2e-31 108.3 1.7 4.6e-31 108.2 0.1 2.0 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EFA74611.1 - 1.7e-06 27.6 1.9 0.00023 20.7 0.0 3.3 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFA74611.1 - 0.00096 19.0 0.0 0.0027 17.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain ABC_membrane_3 PF13748.6 EFA74611.1 - 0.0023 17.2 6.6 0.0047 16.2 6.6 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_29 PF13555.6 EFA74611.1 - 0.0058 16.3 0.4 0.016 14.9 0.4 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA74611.1 - 0.014 15.7 0.2 0.083 13.2 0.2 2.2 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFA74611.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase MotA_ExbB PF01618.16 EFA74611.1 - 0.079 12.7 0.1 0.27 11.0 0.1 1.9 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family CmcI PF04989.12 EFA74611.1 - 0.1 12.3 0.2 0.31 10.7 0.0 1.8 2 0 0 2 2 2 0 Cephalosporin hydroxylase FNIP PF05725.12 EFA74612.1 - 1.5e-66 220.3 35.6 1.4e-16 60.3 1.0 7.3 4 2 1 7 7 7 5 FNIP Repeat Pkinase PF00069.25 EFA74612.1 - 1.3e-19 70.6 4.0 1.3e-19 70.6 4.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Imm5 PF14423.6 EFA74612.1 - 0.091 13.0 0.8 0.17 12.1 0.8 1.4 1 0 0 1 1 1 0 Immunity protein Imm5 Ku_PK_bind PF08785.11 EFA74613.1 - 3.6e-10 40.0 0.1 7.2e-10 39.1 0.1 1.5 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EFA74613.1 - 9.6e-10 38.5 0.0 1.9e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 EFA74613.1 - 4.7e-05 24.0 1.5 0.00015 22.3 1.5 1.9 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm Ydc2-catalyt PF09159.10 EFA74613.1 - 0.15 11.8 4.3 0.78 9.4 0.5 2.1 2 0 0 2 2 2 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 CHIP_TPR_N PF18391.1 EFA74613.1 - 0.3 11.9 4.9 12 6.8 0.1 2.6 3 0 0 3 3 3 0 CHIP N-terminal tetratricopeptide repeat domain RT_RNaseH_2 PF17919.1 EFA74614.1 - 4.5e-27 94.0 0.0 9.7e-27 92.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA74614.1 - 6.9e-26 90.6 0.0 1.3e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EFA74614.1 - 1.2e-15 57.4 0.5 2.6e-15 56.2 0.5 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Fzo_mitofusin PF04799.13 EFA74616.1 - 0.087 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 fzo-like conserved region Uma2 PF05685.12 EFA74617.1 - 1.2e-05 24.9 0.0 2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease Kelch_6 PF13964.6 EFA74618.1 - 4.9e-05 23.5 0.0 0.015 15.6 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 EFA74619.1 - 1.2e-18 66.6 7.1 5.1e-10 39.3 0.1 5.8 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFA74619.1 - 0.0027 17.3 0.1 0.041 13.5 0.0 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 EFA74619.1 - 0.0036 17.3 0.2 3.5 7.7 0.0 4.3 3 1 0 3 3 3 1 Galactose oxidase, central domain Saccharop_dh_N PF04455.12 EFA74619.1 - 0.0064 16.9 1.1 0.015 15.7 0.3 2.0 2 0 0 2 2 2 1 LOR/SDH bifunctional enzyme conserved region Ntox28 PF15605.6 EFA74619.1 - 0.022 15.0 1.0 0.061 13.6 0.1 2.2 2 0 0 2 2 2 0 Bacterial toxin 28 Kelch_2 PF07646.15 EFA74619.1 - 0.099 12.7 1.9 1.2 9.2 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 EFA74619.1 - 0.48 10.5 0.1 0.48 10.5 0.1 2.6 2 0 0 2 2 2 0 Kelch motif Pkinase PF00069.25 EFA74620.1 - 1.9e-45 155.3 0.0 3.2e-45 154.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74620.1 - 4.4e-26 91.7 0.0 7.2e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA74620.1 - 0.034 13.5 0.0 0.23 10.7 0.0 2.2 2 1 0 2 2 2 0 Kinase-like Pox_polyA_pol_N PF12630.7 EFA74623.1 - 0.15 12.5 0.8 0.45 10.9 0.1 2.2 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain Osteopontin PF00865.18 EFA74623.1 - 9.2 5.7 15.1 14 5.0 15.1 1.2 1 0 0 1 1 1 0 Osteopontin TIG PF01833.24 EFA74625.1 - 3.6e-29 100.7 81.0 6.2e-09 35.8 6.0 10.5 10 0 0 10 10 10 7 IPT/TIG domain DNase_II PF03265.15 EFA74625.1 - 1.7e-23 83.4 9.8 1.7e-23 83.4 9.8 2.6 2 1 0 2 2 2 1 Deoxyribonuclease II SdrD_B PF17210.3 EFA74625.1 - 1.2e-07 31.9 1.0 1.2e-07 31.9 1.0 4.3 4 0 0 4 4 4 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA74625.1 - 0.0013 18.9 0.6 0.009 16.3 0.6 2.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFA74625.1 - 0.016 15.2 1.0 0.058 13.4 1.0 2.1 1 0 0 1 1 1 0 CarboxypepD_reg-like domain MetallophosN PF16371.5 EFA74625.1 - 0.065 13.5 1.8 0.18 12.1 0.2 2.6 2 0 0 2 2 2 0 N terminal of Calcineurin-like phosphoesterase DUF787 PF05619.11 EFA74626.1 - 0.0025 17.0 0.2 0.0039 16.4 0.2 1.3 1 0 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF787) Smr PF01713.21 EFA74626.1 - 0.027 14.8 0.0 0.052 13.9 0.0 1.5 1 0 0 1 1 1 0 Smr domain Utp14 PF04615.13 EFA74626.1 - 0.2 10.2 2.5 0.24 9.9 2.5 1.1 1 0 0 1 1 1 0 Utp14 protein IBR PF01485.21 EFA74627.1 - 3.9e-19 68.6 53.9 4.7e-14 52.4 6.6 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFA74627.1 - 0.00012 22.4 4.2 0.00012 22.4 4.2 4.5 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA74627.1 - 0.00037 20.3 1.4 0.00037 20.3 1.4 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA74627.1 - 0.0032 17.4 1.6 0.0032 17.4 1.6 3.5 3 0 0 3 3 3 1 RING-type zinc-finger Cwf_Cwc_15 PF04889.12 EFA74627.1 - 0.0038 17.0 13.6 0.0038 17.0 13.6 3.4 3 0 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein zf-C3HC4 PF00097.25 EFA74627.1 - 0.0047 16.8 4.4 0.0047 16.8 4.4 4.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Cupin_8 PF13621.6 EFA74628.1 - 1e-36 127.0 1.5 1.1e-36 126.9 0.1 1.6 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 EFA74628.1 - 0.00012 21.7 0.0 0.00025 20.6 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein DUF677 PF05055.12 EFA74628.1 - 0.056 12.3 1.1 5.9 5.7 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF677) Endotoxin_N PF03945.14 EFA74629.1 - 8.4e-07 28.9 0.0 0.00013 21.7 0.0 2.3 1 1 0 1 1 1 1 delta endotoxin, N-terminal domain ImcF-related_N PF14331.6 EFA74629.1 - 0.093 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 ImcF-related N-terminal domain SurA_N_3 PF13624.6 EFA74629.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 SurA N-terminal domain ADH_N PF08240.12 EFA74630.1 - 1.7e-26 92.3 6.0 1.7e-26 92.3 6.0 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFA74630.1 - 4.9e-17 62.1 0.0 8.4e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA74630.1 - 0.00019 22.5 0.0 0.00032 21.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Oxidored_nitro PF00148.19 EFA74630.1 - 0.0015 17.3 0.0 0.0023 16.7 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase CoA_binding PF02629.19 EFA74630.1 - 0.004 17.8 0.0 0.1 13.3 0.0 2.6 3 0 0 3 3 3 1 CoA binding domain ELFV_dehydrog PF00208.21 EFA74630.1 - 0.053 13.2 0.2 0.086 12.5 0.2 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Peptidase_C1 PF00112.23 EFA74631.1 - 1.2e-64 218.4 4.1 1.5e-64 218.1 4.1 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EFA74631.1 - 1.8e-10 40.5 0.0 3.4e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EFA74631.1 - 1.2e-05 24.3 3.2 0.0015 17.4 0.8 2.3 2 0 0 2 2 2 2 Peptidase C1-like family CoA_transf_3 PF02515.17 EFA74634.1 - 1.8e-81 274.1 0.0 2.3e-81 273.8 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III ACOX PF01756.19 EFA74635.1 - 1.3e-51 174.7 0.0 1.2e-50 171.6 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EFA74635.1 - 2.5e-18 66.8 0.0 4.5e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EFA74635.1 - 1.4e-13 50.8 0.0 2.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFA74635.1 - 0.0076 16.5 0.0 0.023 14.9 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain F-box PF00646.33 EFA74637.1 - 4.4e-08 32.8 0.1 9.4e-08 31.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA74637.1 - 6.1e-08 32.4 0.1 1.7e-07 31.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFA74637.1 - 0.027 14.3 0.4 0.069 13.0 0.0 1.9 2 0 0 2 2 2 0 F-box Arm PF00514.23 EFA74639.1 - 3.7e-05 23.6 0.0 0.0044 17.0 0.0 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat F-box PF00646.33 EFA74639.1 - 4.5e-05 23.2 0.0 0.00027 20.7 0.0 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFA74639.1 - 5.4e-05 23.0 0.1 0.00023 21.0 0.0 2.1 2 0 0 2 2 2 1 F-box-like Atx10homo_assoc PF09759.9 EFA74639.1 - 0.023 14.7 0.1 0.14 12.2 0.1 2.4 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain SWI-SNF_Ssr4 PF08549.10 EFA74640.1 - 0.42 9.2 14.7 0.0065 15.2 6.5 2.0 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) DUF4551 PF15087.6 EFA74640.1 - 8.6 5.1 9.6 13 4.5 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF202 PF02656.15 EFA74641.1 - 0.001 19.5 1.8 0.001 19.5 1.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PALP PF00291.25 EFA74642.1 - 4.7e-56 190.4 0.0 5.5e-56 190.1 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TFIID-18kDa PF02269.16 EFA74643.1 - 6.9e-30 102.9 1.4 1e-29 102.4 1.4 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit SOG2 PF10428.9 EFA74643.1 - 0.079 12.2 17.3 0.093 11.9 17.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 EFA74643.1 - 0.13 10.9 14.1 0.13 10.9 14.1 1.1 1 0 0 1 1 1 0 Hamartin protein FTCD_C PF04961.12 EFA74643.1 - 0.2 11.4 0.7 0.33 10.7 0.7 1.3 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase SPX PF03105.19 EFA74643.1 - 0.57 10.0 9.7 0.66 9.8 9.7 1.2 1 0 0 1 1 1 0 SPX domain FNIP PF05725.12 EFA74644.1 - 2.9e-42 142.6 32.2 9.2e-15 54.5 5.9 7.4 4 2 3 7 7 7 7 FNIP Repeat Pkinase PF00069.25 EFA74644.1 - 1.8e-26 93.1 2.2 1.8e-26 93.1 2.2 2.7 2 1 0 2 2 2 1 Protein kinase domain U1snRNP70_N PF12220.8 EFA74644.1 - 0.037 14.7 1.9 0.12 13.1 1.9 1.8 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF1501 PF07394.12 EFA74644.1 - 0.05 12.7 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) APH PF01636.23 EFA74644.1 - 0.059 13.3 0.2 0.098 12.6 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Phage_lambda_P PF06992.11 EFA74644.1 - 0.24 11.1 0.8 0.5 10.1 0.8 1.5 1 0 0 1 1 1 0 Replication protein P RhoGEF PF00621.20 EFA74645.1 - 1.7e-06 28.4 0.1 1.7e-06 28.4 0.1 2.1 2 0 0 2 2 2 1 RhoGEF domain Nop14 PF04147.12 EFA74645.1 - 0.002 16.4 38.4 0.002 16.4 38.4 2.1 1 1 1 2 2 2 1 Nop14-like family vMSA PF00695.19 EFA74645.1 - 1.2 8.2 3.6 1.8 7.6 3.6 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus PH PF00169.29 EFA74646.1 - 2.7e-06 27.8 0.2 6.7e-06 26.6 0.2 1.7 1 0 0 1 1 1 1 PH domain DUF2799 PF10973.8 EFA74646.1 - 0.11 12.9 0.1 0.21 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2799) Ribosom_S12_S23 PF00164.25 EFA74647.1 - 4.2e-48 161.7 0.6 5.8e-48 161.3 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF592 PF04574.13 EFA74648.1 - 0.052 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF592) PGA_cap PF09587.10 EFA74648.1 - 0.16 11.4 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap Tyrosinase PF00264.20 EFA74650.1 - 1.2e-34 120.5 17.3 3.2e-33 115.9 14.5 2.8 2 1 0 2 2 2 1 Common central domain of tyrosinase BNR_2 PF13088.6 EFA74650.1 - 0.0036 16.7 0.0 0.87 8.8 0.0 2.5 1 1 1 2 2 2 2 BNR repeat-like domain ATP_bind_1 PF03029.17 EFA74651.1 - 1.2e-86 290.4 0.2 1.4e-86 290.3 0.2 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EFA74651.1 - 0.0001 22.2 0.0 0.033 14.0 0.0 2.5 2 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 EFA74651.1 - 0.00014 22.4 3.5 0.0012 19.4 0.6 2.8 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EFA74651.1 - 0.00055 19.5 0.0 0.0031 17.1 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_30 PF13604.6 EFA74651.1 - 0.00077 19.2 0.0 0.0016 18.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFA74651.1 - 0.0032 17.2 0.2 0.0091 15.7 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFA74651.1 - 0.017 15.0 0.3 4 7.3 0.0 3.1 2 1 0 3 3 3 0 RsgA GTPase AAA_22 PF13401.6 EFA74651.1 - 0.022 15.0 0.2 0.093 13.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain KTI12 PF08433.10 EFA74651.1 - 0.024 14.1 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 PduV-EutP PF10662.9 EFA74651.1 - 0.025 14.3 0.1 7 6.4 0.1 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF3368 PF11848.8 EFA74651.1 - 0.035 13.9 0.0 0.44 10.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) AAA_16 PF13191.6 EFA74651.1 - 0.041 14.3 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFA74651.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFA74651.1 - 0.077 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_PrkA PF08298.11 EFA74651.1 - 0.081 11.8 0.0 0.19 10.6 0.0 1.6 1 1 0 1 1 1 0 PrkA AAA domain ABC_tran PF00005.27 EFA74651.1 - 0.082 13.4 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 EFA74651.1 - 0.11 12.8 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EFA74651.1 - 0.18 11.7 0.1 3.4 7.5 0.1 2.4 1 1 0 1 1 1 0 NTPase Mg_chelatase PF01078.21 EFA74651.1 - 0.19 11.1 0.1 0.33 10.3 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MeaB PF03308.16 EFA74651.1 - 0.24 10.3 0.0 0.63 9.0 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FNIP PF05725.12 EFA74652.1 - 4e-156 507.0 80.9 1.3e-17 63.6 1.1 12.4 9 1 3 13 13 13 12 FNIP Repeat Pkinase PF00069.25 EFA74652.1 - 1.2e-29 103.5 9.8 6.5e-28 97.8 6.8 2.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74652.1 - 1.1e-12 47.8 0.9 1.2e-09 37.8 0.9 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase AbiJ_NTD5 PF18865.1 EFA74652.1 - 0.00043 20.0 3.7 26 4.7 0.0 7.4 5 2 2 7 7 7 1 AbiJ N-terminal domain 5 APH PF01636.23 EFA74652.1 - 0.0011 19.0 0.0 0.069 13.1 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFA74652.1 - 0.011 15.1 0.0 0.045 13.1 0.0 1.9 2 0 0 2 2 2 0 Kinase-like NADH_u_ox_C PF12853.7 EFA74653.1 - 0.01 15.8 0.1 0.017 15.1 0.1 1.3 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit DUF249 PF03158.13 EFA74654.1 - 0.0025 17.6 0.2 0.0031 17.3 0.2 1.2 1 0 0 1 1 1 1 Multigene family 530 protein FNIP PF05725.12 EFA74655.1 - 2.4e-63 210.1 33.6 7.6e-17 61.2 2.0 8.4 6 2 1 8 8 8 5 FNIP Repeat Pkinase PF00069.25 EFA74655.1 - 6.7e-27 94.5 8.0 9.5e-26 90.7 5.2 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74655.1 - 2.7e-11 43.3 0.5 5.4e-08 32.4 0.4 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase DnaJ PF00226.31 EFA74656.1 - 1.6e-07 31.3 1.8 3e-07 30.5 1.8 1.5 1 0 0 1 1 1 1 DnaJ domain ATP_bind_1 PF03029.17 EFA74657.1 - 3.6e-25 89.1 0.1 4.1e-25 89.0 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EFA74657.1 - 0.0045 16.8 0.0 0.0045 16.8 0.0 1.1 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 EFA74657.1 - 0.013 15.2 0.0 0.014 15.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFA74657.1 - 0.044 14.3 0.0 0.045 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EFA74657.1 - 0.052 13.1 0.1 0.052 13.1 0.1 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain KTI12 PF08433.10 EFA74657.1 - 0.059 12.8 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MeaB PF03308.16 EFA74657.1 - 0.086 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EFA74657.1 - 0.13 12.7 0.0 0.14 12.6 0.0 1.4 1 1 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EFA74657.1 - 0.16 12.3 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 EFA74658.1 - 2.4e-24 86.1 6.7 9.6e-23 80.9 6.7 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74658.1 - 1e-11 44.6 0.7 1.8e-09 37.3 1.3 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA74658.1 - 0.011 15.1 0.2 0.023 14.0 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Imm5 PF14423.6 EFA74658.1 - 0.045 14.0 0.9 0.09 13.0 0.9 1.5 1 0 0 1 1 1 0 Immunity protein Imm5 APH PF01636.23 EFA74658.1 - 0.18 11.7 0.0 0.79 9.6 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Toxin_YhaV PF11663.8 EFA74660.1 - 0.14 12.2 0.0 0.15 12.2 0.0 1.0 1 0 0 1 1 1 0 Toxin with endonuclease activity, of toxin-antitoxin system Dimer_Tnp_hAT PF05699.14 EFA74661.1 - 3.7e-05 23.4 0.5 4.2e-05 23.3 0.5 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ATP_bind_1 PF03029.17 EFA74665.1 - 4.8e-18 65.8 4.0 9.6e-11 41.9 0.4 2.0 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EFA74665.1 - 0.027 14.4 0.5 0.029 14.3 0.5 1.2 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 EFA74666.1 - 1.6e-24 86.7 2.7 2.9e-22 79.3 2.7 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74666.1 - 4.9e-10 39.1 0.2 3.6e-08 33.0 0.2 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA74666.1 - 0.00029 20.2 0.0 0.00066 19.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFA74666.1 - 0.018 15.0 0.0 0.45 10.4 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family PIP49_C PF12260.8 EFA74666.1 - 0.033 13.8 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 DDE_1 PF03184.19 EFA74667.1 - 2e-12 47.1 0.6 3.8e-12 46.2 0.6 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Cob_adeno_trans PF01923.18 EFA74668.1 - 0.041 14.0 0.1 0.048 13.8 0.1 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase ATP_bind_1 PF03029.17 EFA74670.1 - 4.4e-45 154.3 0.6 5e-45 154.2 0.6 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein DUF3368 PF11848.8 EFA74670.1 - 0.0083 15.9 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3368) FNIP PF05725.12 EFA74671.1 - 1.2e-13 51.0 8.9 3.1e-10 40.0 0.4 4.3 3 2 1 4 4 4 3 FNIP Repeat Pkinase PF00069.25 EFA74672.1 - 2.7e-31 108.9 9.9 2.4e-22 79.6 3.8 2.6 2 1 0 3 3 3 2 Protein kinase domain FNIP PF05725.12 EFA74672.1 - 7.4e-17 61.2 8.8 2.9e-08 33.7 3.1 3.3 2 0 0 2 2 2 2 FNIP Repeat Pkinase_Tyr PF07714.17 EFA74672.1 - 1.1e-14 54.4 1.3 1.3e-10 41.0 0.7 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA74672.1 - 8.9e-05 21.9 0.0 0.00037 19.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFA74672.1 - 0.00014 21.8 0.2 0.018 15.0 0.2 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Imm5 PF14423.6 EFA74672.1 - 0.46 10.7 3.3 0.23 11.7 0.8 1.8 2 0 0 2 2 2 0 Immunity protein Imm5 ATP_bind_1 PF03029.17 EFA74673.1 - 1.2e-42 146.4 0.6 1.3e-42 146.2 0.6 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein DUF3368 PF11848.8 EFA74673.1 - 0.023 14.5 0.0 0.28 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) FNIP PF05725.12 EFA74674.1 - 3.5e-99 324.8 51.2 2.4e-16 59.6 1.5 8.2 4 1 5 10 10 10 9 FNIP Repeat RT_RNaseH_2 PF17919.1 EFA74674.1 - 8.5e-29 99.5 0.0 3.2e-28 97.7 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EFA74674.1 - 1.6e-27 96.5 0.5 3.4e-27 95.4 0.5 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EFA74674.1 - 5.8e-26 90.8 0.3 4.9e-25 87.9 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase Pkinase PF00069.25 EFA74674.1 - 9.4e-26 90.7 3.2 1.7e-24 86.6 3.2 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74674.1 - 2.2e-11 43.6 0.2 8.2e-08 31.8 0.3 2.3 1 1 0 2 2 2 2 Protein tyrosine kinase rve PF00665.26 EFA74674.1 - 0.00048 20.3 0.1 0.0048 17.1 0.1 2.5 1 1 1 2 2 2 1 Integrase core domain Kinase-like PF14531.6 EFA74674.1 - 0.018 14.4 0.0 0.061 12.6 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Glu-tRNAGln PF02686.15 EFA74674.1 - 0.042 14.2 0.1 0.33 11.3 0.1 2.6 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit DUF3734 PF12536.8 EFA74674.1 - 0.16 12.3 1.0 1.4 9.3 0.2 2.8 2 0 0 2 2 2 0 Patatin phospholipase FNIP PF05725.12 EFA74679.1 - 1.6e-101 332.2 58.3 9.7e-18 64.1 0.5 11.2 5 2 3 9 9 9 8 FNIP Repeat Pkinase PF00069.25 EFA74679.1 - 6e-31 107.8 4.2 6e-31 107.8 4.2 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74679.1 - 1.4e-12 47.4 0.3 3.2e-09 36.5 0.3 2.4 1 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA74679.1 - 0.00059 19.2 0.0 0.0049 16.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DDE_Tnp_4 PF13359.6 EFA74680.1 - 2.3e-07 30.6 0.0 2.7e-07 30.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Ank_4 PF13637.6 EFA74682.1 - 0.003 18.1 0.0 0.44 11.2 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74682.1 - 0.013 16.0 0.0 22 6.1 0.0 3.6 3 1 1 4 4 4 0 Ankyrin repeat Ank_2 PF12796.7 EFA74682.1 - 0.022 15.3 0.0 0.28 11.8 0.0 2.1 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) DUF3447 PF11929.8 EFA74682.1 - 0.047 13.6 0.0 0.11 12.5 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3447) Ank_5 PF13857.6 EFA74682.1 - 0.13 12.6 0.0 0.51 10.7 0.0 2.0 2 1 0 2 2 2 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA74683.1 - 9.4e-11 42.0 0.6 3.4e-05 24.3 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA74683.1 - 9.7e-10 38.9 0.0 1.5e-06 28.7 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA74683.1 - 1e-07 32.1 0.0 0.75 10.2 0.0 4.4 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74683.1 - 5.5e-05 23.3 0.0 10 7.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat IL12p40_C PF10420.9 EFA74683.1 - 0.062 13.8 2.6 0.16 12.5 2.5 1.8 1 1 0 1 1 1 0 Cytokine interleukin-12p40 C-terminus YvbH_ext PF11724.8 EFA74683.1 - 0.17 12.2 2.7 1.8 8.9 0.1 2.7 2 1 1 3 3 3 0 YvbH-like oligomerisation region EGF_2 PF07974.13 EFA74685.1 - 0.0012 19.1 13.6 0.0027 18.0 13.6 1.5 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA74685.1 - 0.074 13.4 7.5 0.19 12.1 7.5 1.7 1 0 0 1 1 1 0 EGF-like domain EGF_alliinase PF04863.13 EFA74685.1 - 0.09 13.2 5.0 0.23 11.9 5.0 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain Laminin_EGF PF00053.24 EFA74685.1 - 0.16 12.1 9.0 0.34 11.1 9.0 1.5 1 0 0 1 1 1 0 Laminin EGF domain TMEM154 PF15102.6 EFA74685.1 - 1.4 8.8 5.2 5 7.0 5.2 1.9 1 0 0 1 1 1 0 TMEM154 protein family DnaJ PF00226.31 EFA74686.1 - 4.3e-23 81.2 2.2 4.1e-22 78.1 0.4 2.4 2 0 0 2 2 2 1 DnaJ domain DnaJ-X PF14308.6 EFA74686.1 - 2.8e-15 56.3 6.6 8.3e-12 45.0 3.5 4.2 2 1 1 3 3 3 2 X-domain of DnaJ-containing Armet PF10208.9 EFA74686.1 - 0.055 13.4 0.0 0.055 13.4 0.0 2.5 3 0 0 3 3 3 0 Degradation arginine-rich protein for mis-folding FNIP PF05725.12 EFA74687.1 - 3.3e-46 155.2 47.2 2.2e-13 50.1 3.6 6.9 2 1 4 7 7 7 6 FNIP Repeat Pkinase PF00069.25 EFA74687.1 - 3e-20 72.7 3.5 6.3e-15 55.2 0.8 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74687.1 - 1e-07 31.5 0.1 3.9e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase IgaA PF07095.11 EFA74687.1 - 0.0016 16.5 0.2 0.0024 15.9 0.2 1.2 1 0 0 1 1 1 1 Intracellular growth attenuator protein IgaA YrbL-PhoP_reg PF10707.9 EFA74687.1 - 0.028 13.9 0.5 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Pkinase_Tyr PF07714.17 EFA74689.1 - 1.6e-65 220.9 0.0 2.6e-65 220.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA74689.1 - 8.1e-49 166.4 0.4 1.8e-48 165.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain SPRY PF00622.28 EFA74689.1 - 9.5e-41 138.7 16.9 1.1e-19 70.7 0.1 4.6 3 1 1 4 4 4 3 SPRY domain SAM_2 PF07647.17 EFA74689.1 - 2.1e-17 63.0 0.0 5.1e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFA74689.1 - 3.2e-16 59.5 0.0 7.2e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EFA74689.1 - 0.022 13.6 0.0 0.022 13.6 0.0 3.7 3 1 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EFA74689.1 - 0.057 13.3 0.0 9.8 6.0 0.0 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Myb_DNA-bind_7 PF15963.5 EFA74690.1 - 9.4e-27 92.7 2.5 9.4e-27 92.7 2.5 3.6 3 1 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EFA74690.1 - 9.9e-09 35.3 0.0 2.1e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA74690.1 - 0.0013 19.0 0.2 0.004 17.4 0.2 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain PBP1_TM PF14812.6 EFA74690.1 - 0.0037 17.6 4.4 0.0037 17.6 4.4 6.4 6 2 1 7 7 7 1 Transmembrane domain of transglycosylase PBP1 at N-terminal SANT_DAMP1_like PF16282.5 EFA74690.1 - 0.025 14.7 0.3 0.097 12.9 0.3 2.0 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 SAP18 PF06487.12 EFA74691.1 - 1.1e-25 90.5 1.3 1.7e-25 89.9 1.3 1.4 1 1 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Methyltransf_11 PF08241.12 EFA74692.1 - 1.4e-19 70.5 0.0 2.4e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA74692.1 - 1.3e-15 57.8 0.0 2.2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA74692.1 - 1.2e-14 54.5 0.0 1.6e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA74692.1 - 3.3e-11 43.2 0.0 5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA74692.1 - 5.6e-10 39.9 0.0 9.8e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA74692.1 - 2.3e-06 27.1 0.0 3.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EFA74692.1 - 0.0025 17.7 0.0 0.0044 16.9 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase CMAS PF02353.20 EFA74692.1 - 0.0047 16.3 0.0 0.0065 15.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EFA74692.1 - 0.0062 16.1 0.0 0.059 12.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_29 PF03141.16 EFA74692.1 - 0.0071 14.9 0.0 0.021 13.4 0.0 1.6 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.17 EFA74692.1 - 0.03 13.8 0.0 0.12 11.8 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_15 PF09445.10 EFA74692.1 - 0.03 13.9 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 EFA74692.1 - 0.045 12.8 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 EFA74692.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFA74693.1 - 7.4e-18 65.0 0.0 1.2e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA74693.1 - 5.1e-15 56.0 0.0 8.7e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA74693.1 - 8.2e-15 55.0 0.0 1.1e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA74693.1 - 8e-11 42.0 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA74693.1 - 7e-10 39.6 0.0 1.3e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA74693.1 - 3.7e-06 26.5 0.0 6.5e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFA74693.1 - 0.0028 17.2 0.0 0.014 14.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 EFA74693.1 - 0.0035 17.2 0.0 0.0061 16.4 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_15 PF09445.10 EFA74693.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CMAS PF02353.20 EFA74693.1 - 0.025 13.9 0.0 0.059 12.7 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EFA74693.1 - 0.042 13.3 0.0 0.16 11.4 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_29 PF03141.16 EFA74693.1 - 0.12 10.9 0.0 0.81 8.2 0.0 1.9 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 EFA74693.1 - 0.19 11.7 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain FNIP PF05725.12 EFA74694.1 - 3.8e-107 350.3 50.7 1.5e-15 57.0 1.8 9.2 3 1 3 10 10 10 9 FNIP Repeat Pkinase PF00069.25 EFA74694.1 - 1.5e-31 109.8 2.1 2.4e-30 105.8 2.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74694.1 - 1.8e-13 50.4 0.1 1.8e-10 40.5 0.2 2.3 1 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA74694.1 - 0.0034 16.7 0.0 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFA74694.1 - 0.05 13.5 0.0 0.43 10.5 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4860 PF16152.5 EFA74694.1 - 1 9.2 5.0 1.2 9.0 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4860) Uma2 PF05685.12 EFA74696.1 - 0.072 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative restriction endonuclease VCBS PF13517.6 EFA74697.1 - 2.4e-21 76.1 31.5 2.2e-06 28.2 1.4 6.4 4 2 3 7 7 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFA74697.1 - 6.9e-21 74.0 27.6 0.0014 18.7 1.9 7.6 7 0 0 7 7 7 7 FG-GAP repeat TMEM154 PF15102.6 EFA74697.1 - 1.4e-05 25.0 0.9 1.4e-05 25.0 0.9 2.2 1 1 1 2 2 1 1 TMEM154 protein family Insulin_TMD PF17870.1 EFA74697.1 - 0.0077 16.3 1.4 0.021 14.9 1.4 1.7 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment Dicty_REP PF05086.12 EFA74697.1 - 0.02 12.9 5.7 0.028 12.4 5.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1180 PF06679.12 EFA74697.1 - 0.03 14.7 1.1 0.048 14.1 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Amnionless PF14828.6 EFA74697.1 - 0.068 12.0 0.2 0.1 11.4 0.2 1.2 1 0 0 1 1 1 0 Amnionless RIFIN PF02009.16 EFA74697.1 - 0.11 12.4 0.1 0.17 11.7 0.1 1.2 1 0 0 1 1 1 0 Rifin Mucin PF01456.17 EFA74697.1 - 3.8 7.5 37.1 7.3 6.6 37.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Strabismus PF06638.11 EFA74697.1 - 3.9 6.0 4.4 5.8 5.5 4.4 1.1 1 0 0 1 1 1 0 Strabismus protein DUF5305 PF17231.2 EFA74697.1 - 4.9 6.5 11.6 9.8 5.5 11.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Phosphorylase PF00343.20 EFA74698.1 - 0 1043.8 0.0 0 1043.6 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Hydrolase_4 PF12146.8 EFA74699.1 - 5e-32 111.1 0.3 1.2e-31 109.8 0.3 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA74699.1 - 1.1e-09 38.3 0.6 7.3e-09 35.6 0.2 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA74699.1 - 8.7e-08 33.0 0.0 1.2e-07 32.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EFA74699.1 - 0.0013 18.3 0.1 0.0022 17.6 0.1 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 EFA74699.1 - 0.0089 15.9 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ku PF02735.16 EFA74700.1 - 1.6e-16 60.6 0.0 1.9e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Pkinase PF00069.25 EFA74701.1 - 6.2e-32 111.0 8.6 1.8e-31 109.5 6.0 2.5 2 1 0 2 2 2 1 Protein kinase domain FNIP PF05725.12 EFA74701.1 - 4.4e-29 100.4 14.9 3.2e-14 52.8 0.3 5.4 4 1 1 5 5 5 3 FNIP Repeat Pkinase_Tyr PF07714.17 EFA74701.1 - 1.1e-13 51.1 0.7 1.2e-11 44.4 0.7 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA74701.1 - 0.017 14.4 0.0 0.095 12.0 0.0 2.0 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 EFA74701.1 - 0.038 13.9 0.0 1.6 8.6 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Hydrolase_4 PF12146.8 EFA74702.1 - 1.3e-38 132.6 0.3 1.8e-38 132.2 0.3 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA74702.1 - 1.3e-10 41.4 2.1 3.2e-09 36.8 0.2 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA74702.1 - 5.5e-09 36.9 0.0 8.1e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFA74702.1 - 0.00028 20.4 0.7 0.042 13.3 0.3 2.5 2 1 0 2 2 2 1 Prolyl oligopeptidase family PGAP1 PF07819.13 EFA74702.1 - 0.00029 20.6 0.4 0.00063 19.5 0.3 1.6 1 1 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EFA74702.1 - 0.015 15.1 0.1 0.038 13.8 0.0 1.5 1 1 0 1 1 1 0 Palmitoyl protein thioesterase Ser_hydrolase PF06821.13 EFA74702.1 - 0.019 14.8 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase DUF2920 PF11144.8 EFA74702.1 - 0.025 13.7 0.7 2.7 7.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) DUF1882 PF08966.11 EFA74702.1 - 0.031 14.5 0.6 5.6 7.3 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1882) DUF915 PF06028.11 EFA74702.1 - 0.048 13.0 3.5 0.066 12.5 0.0 2.6 4 0 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 EFA74702.1 - 0.066 12.8 0.1 0.11 12.0 0.1 1.4 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Esterase PF00756.20 EFA74702.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.4 1 1 0 1 1 1 0 Putative esterase Mucin PF01456.17 EFA74703.1 - 0.13 12.3 13.9 0.13 12.2 13.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein zf_CCCH_4 PF18345.1 EFA74704.1 - 1.5e-09 37.5 18.6 1.1e-05 25.2 2.6 2.9 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_3 PF15663.5 EFA74704.1 - 1.8e-07 31.3 7.8 1.8e-07 31.3 7.8 2.7 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EFA74704.1 - 6e-06 26.5 24.9 0.049 14.1 6.7 3.6 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 EFA74704.1 - 6.8e-06 25.9 15.4 0.00039 20.2 0.5 3.2 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFA74704.1 - 7.4e-05 22.4 15.6 0.0025 17.6 0.5 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger TFIIA PF03153.13 EFA74704.1 - 0.0031 17.6 20.8 0.0031 17.6 20.8 3.3 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Patatin PF01734.22 EFA74705.1 - 4.8e-16 59.5 1.9 8.3e-16 58.8 1.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase DUF5353 PF17304.2 EFA74705.1 - 0.053 13.3 1.2 0.13 12.0 1.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5353) DUF1079 PF06435.11 EFA74705.1 - 0.78 10.0 4.2 1.8 8.8 1.0 2.8 2 0 0 2 2 2 0 Repeat of unknown function (DUF1079) Pkinase PF00069.25 EFA74706.1 - 2.2e-45 155.1 0.1 2.2e-45 155.1 0.1 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74706.1 - 3.9e-22 78.8 0.0 1.3e-21 77.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase UPF0242 PF06785.11 EFA74706.1 - 0.41 10.7 9.8 0.83 9.7 9.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TGF_beta_GS PF08515.12 EFA74706.1 - 0.78 9.3 4.9 2.4 7.7 4.9 1.8 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif DUF4175 PF13779.6 EFA74706.1 - 0.9 7.4 6.8 1.6 6.5 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DPM3 PF08285.11 EFA74707.1 - 3.5e-22 78.4 0.5 4.4e-22 78.1 0.5 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) EB PF01683.18 EFA74709.1 - 0.0013 18.9 1.2 0.003 17.8 1.2 1.5 1 0 0 1 1 1 1 EB module Crystall_2 PF09076.10 EFA74709.1 - 0.0056 16.5 3.5 0.006 16.4 0.4 2.5 2 0 0 2 2 2 1 Beta/Gamma crystallin EGF_Tenascin PF18720.1 EFA74709.1 - 1.9 8.7 6.3 5.6 7.1 6.3 1.8 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 EFA74709.1 - 6.9 7.1 12.6 1.8 8.9 8.7 2.1 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 EFA74709.1 - 7.6 7.3 8.8 3.5 8.4 4.4 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF DUF5390 PF17365.2 EFA74710.1 - 0.047 14.0 0.8 0.099 12.9 0.8 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5390) BCIP PF13862.6 EFA74711.1 - 2e-45 155.2 5.1 2e-45 155.2 5.1 2.8 2 1 0 2 2 2 1 p21-C-terminal region-binding protein Ndc1_Nup PF09531.10 EFA74711.1 - 1.4 7.5 15.0 0.15 10.7 10.3 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup V_ATPase_I PF01496.19 EFA74712.1 - 3e-284 945.0 1.9 3.7e-284 944.7 1.9 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Vps5 PF09325.10 EFA74712.1 - 0.015 14.9 0.9 0.025 14.1 0.9 1.3 1 0 0 1 1 1 0 Vps5 C terminal like Cep57_MT_bd PF06657.13 EFA74712.1 - 0.039 14.4 0.6 0.13 12.7 0.6 1.9 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF4337 PF14235.6 EFA74712.1 - 0.086 12.9 0.1 4.5 7.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) FlaC_arch PF05377.11 EFA74712.1 - 0.22 11.9 2.8 0.73 10.3 2.8 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Mating_C PF12737.7 EFA74713.1 - 0.07 12.3 0.9 0.093 11.9 0.9 1.1 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 Fz PF01392.22 EFA74714.1 - 2.6e-06 28.0 2.3 5.5e-06 27.0 2.3 1.5 1 0 0 1 1 1 1 Fz domain Dickkopf_N PF04706.12 EFA74715.1 - 0.0014 19.1 3.8 0.0014 19.1 3.8 6.6 3 3 3 6 6 6 4 Dickkopf N-terminal cysteine-rich region MIG-14_Wnt-bd PF06664.12 EFA74716.1 - 3.4e-60 203.7 27.2 4.5e-60 203.4 26.5 1.5 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion TrmO PF01980.16 EFA74717.1 - 1.4e-40 138.2 0.0 2.8e-40 137.2 0.0 1.5 1 0 0 1 1 1 1 tRNA-methyltransferase O DUF4748 PF15932.5 EFA74717.1 - 0.046 13.5 2.7 0.068 12.9 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4748) Connexin PF00029.19 EFA74717.1 - 9.3 5.9 6.2 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Connexin DnaJ_C PF01556.18 EFA74718.1 - 4.4e-40 137.2 1.4 6.1e-40 136.7 1.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFA74718.1 - 1.6e-27 95.4 2.2 2.8e-27 94.6 2.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFA74718.1 - 1.7e-16 60.3 18.0 2.9e-16 59.6 18.0 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EFA74718.1 - 0.0045 17.0 8.7 0.56 10.3 3.1 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EFA74718.1 - 0.019 14.9 13.6 0.12 12.3 1.3 3.1 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF971 PF06155.12 EFA74718.1 - 0.3 11.7 4.8 4.3 8.0 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF971) zf-RING_10 PF16685.5 EFA74718.1 - 1.5 9.0 8.3 0.13 12.4 1.3 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 CLASP_N PF12348.8 EFA74719.1 - 6e-30 104.5 2.4 6e-30 104.5 2.4 1.8 2 0 0 2 2 2 1 CLASP N terminal V_ATPase_I PF01496.19 EFA74721.1 - 4.4e-302 1004.0 2.6 8e-302 1003.1 2.6 1.4 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family FTA4 PF13093.6 EFA74721.1 - 0.015 15.2 1.4 0.032 14.1 1.4 1.5 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Filament PF00038.21 EFA74721.1 - 0.024 14.2 5.7 0.043 13.4 5.7 1.3 1 0 0 1 1 1 0 Intermediate filament protein HSBP1 PF06825.12 EFA74721.1 - 0.069 13.0 1.4 0.62 10.0 0.5 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 HMMR_N PF15905.5 EFA74721.1 - 0.082 12.4 6.3 0.15 11.5 6.3 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal SF1-HH PF16275.5 EFA74721.1 - 0.096 13.0 1.2 2.1 8.7 0.9 2.5 2 0 0 2 2 2 0 Splicing factor 1 helix-hairpin domain DUF4140 PF13600.6 EFA74721.1 - 0.35 11.3 1.3 0.78 10.2 1.3 1.6 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HalX PF08663.10 EFA74721.1 - 0.57 10.5 3.7 1.1 9.6 3.7 1.5 1 0 0 1 1 1 0 HalX domain NPV_P10 PF05531.12 EFA74721.1 - 0.59 10.6 4.0 2.1 8.9 1.3 2.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlxA PF14282.6 EFA74721.1 - 1.3 9.0 6.9 0.13 12.2 1.8 1.8 2 0 0 2 2 2 0 FlxA-like protein Fib_alpha PF08702.10 EFA74721.1 - 2.3 8.4 9.1 0.38 10.9 4.1 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Occludin_ELL PF07303.13 EFA74721.1 - 4.9 7.9 6.7 14 6.4 0.4 3.3 3 0 0 3 3 3 0 Occludin homology domain Adaptin_N PF01602.20 EFA74723.1 - 1.4e-113 380.3 19.2 5.4e-85 285.9 9.3 2.1 1 1 1 2 2 2 2 Adaptin N terminal region AP3B1_C PF14796.6 EFA74723.1 - 1.4e-15 57.8 0.0 4.7e-15 56.1 0.0 1.9 1 0 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Cnd1 PF12717.7 EFA74723.1 - 5.4e-08 33.0 8.6 0.011 15.8 0.4 5.0 2 2 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA74723.1 - 6.1e-06 26.5 0.1 0.033 14.6 0.0 3.9 2 1 1 3 3 3 2 HEAT repeats GUN4_N PF16416.5 EFA74723.1 - 0.085 12.9 0.0 1.2 9.2 0.0 2.8 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal HEAT PF02985.22 EFA74723.1 - 0.14 12.4 4.7 32 5.2 0.0 5.0 5 0 0 5 5 5 0 HEAT repeat Svf1_C PF17187.4 EFA74723.1 - 0.81 9.5 4.2 0.35 10.7 0.2 2.4 2 0 0 2 2 2 0 Svf1-like C-terminal lipocalin-like domain CDC45 PF02724.14 EFA74723.1 - 4 5.6 20.8 11 4.2 18.5 2.0 2 0 0 2 2 2 0 CDC45-like protein Pkinase PF00069.25 EFA74724.1 - 3.3e-60 203.7 0.0 3.3e-60 203.7 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74724.1 - 6.2e-21 74.8 0.0 6.2e-21 74.8 0.0 2.7 3 0 0 3 3 3 1 Protein tyrosine kinase Ribonuc_red_sm PF00268.21 EFA74725.1 - 4.2e-120 400.4 2.3 5.1e-120 400.1 2.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 EFA74725.1 - 0.14 13.0 0.0 0.31 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) SapB_1 PF05184.15 EFA74725.1 - 9.8 6.3 6.3 24 5.0 0.4 2.7 3 0 0 3 3 3 0 Saposin-like type B, region 1 Transketolase_N PF00456.21 EFA74726.1 - 4.2e-107 358.0 0.2 6e-107 357.5 0.2 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EFA74726.1 - 4.4e-43 147.0 0.0 8.5e-43 146.1 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFA74726.1 - 2.4e-09 37.1 0.0 6.3e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EFA74726.1 - 5.7e-08 32.3 0.5 2.4e-05 23.7 0.1 3.1 2 1 1 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EFA74726.1 - 0.0014 18.4 0.2 0.016 15.0 0.3 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 EFA74726.1 - 0.032 13.2 0.1 0.058 12.3 0.1 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component Ras PF00071.22 EFA74727.1 - 1.5e-47 161.2 0.0 6.3e-47 159.2 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA74727.1 - 1.5e-24 86.5 0.0 1.3e-23 83.4 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA74727.1 - 1.3e-08 34.5 0.0 2.4e-08 33.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA74727.1 - 0.0064 16.1 0.0 0.013 15.0 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA74727.1 - 0.014 15.3 0.1 0.021 14.7 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase FeoB_N PF02421.18 EFA74727.1 - 0.095 12.2 0.2 0.16 11.5 0.2 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B TerD PF02342.18 EFA74728.1 - 6.5e-72 240.9 0.0 8.1e-72 240.6 0.0 1.0 1 0 0 1 1 1 1 TerD domain Adap_comp_sub PF00928.21 EFA74729.1 - 2.2e-52 178.1 4.0 3.2e-52 177.5 4.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Profilin PF00235.19 EFA74729.1 - 1.6e-10 41.3 0.2 2.7e-10 40.6 0.2 1.4 1 0 0 1 1 1 1 Profilin LSM PF01423.22 EFA74730.1 - 1.2e-19 69.7 1.2 1.8e-19 69.2 1.2 1.3 1 0 0 1 1 1 1 LSM domain WAP PF00095.21 EFA74731.1 - 0.0086 16.4 0.4 0.0086 16.4 0.4 13.1 7 5 2 9 9 9 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DPBB_1 PF03330.18 EFA74732.1 - 1.6e-07 31.5 0.8 1.1e-05 25.6 0.1 3.2 2 1 0 2 2 2 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 EFA74732.1 - 0.0054 16.7 0.0 0.0087 16.1 0.0 1.3 1 0 0 1 1 1 1 Pollen allergen Cerato-platanin PF07249.12 EFA74732.1 - 0.018 15.2 0.1 0.038 14.1 0.1 1.6 1 0 0 1 1 1 0 Cerato-platanin Ribosomal_L20 PF00453.18 EFA74733.1 - 2.1e-36 124.3 1.8 2.6e-36 124.0 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 HTH_21 PF13276.6 EFA74733.1 - 0.0029 17.7 0.9 0.0047 17.0 0.9 1.4 1 0 0 1 1 1 1 HTH-like domain DUF424 PF04242.13 EFA74733.1 - 0.025 14.8 0.0 6.6 7.1 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF424) TIG PF01833.24 EFA74734.1 - 1.8e-19 69.6 47.8 5.7e-08 32.7 4.0 7.2 6 1 1 7 7 7 5 IPT/TIG domain EGF_2 PF07974.13 EFA74734.1 - 8.9e-05 22.8 10.9 0.00036 20.8 10.9 2.1 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA74734.1 - 0.0003 20.7 4.8 0.0003 20.7 4.8 2.4 2 0 0 2 2 2 1 Tenascin EGF domain DUF4333 PF14230.6 EFA74734.1 - 0.053 13.8 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4333) hEGF PF12661.7 EFA74734.1 - 0.37 11.5 11.3 0.26 12.0 5.5 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFA74734.1 - 0.88 9.9 16.8 0.48 10.8 11.2 3.2 2 0 0 2 2 2 0 EGF-like domain CDT1_C PF16679.5 EFA74735.1 - 0.04 14.4 0.3 0.045 14.2 0.3 1.2 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain XK-related PF09815.9 EFA74735.1 - 0.061 12.4 0.1 0.062 12.3 0.1 1.0 1 0 0 1 1 1 0 XK-related protein DUF3800 PF12686.7 EFA74736.1 - 0.022 15.4 0.0 35 5.0 0.0 5.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) DUF2754 PF10953.8 EFA74736.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) QSregVF PF13652.6 EFA74736.1 - 1 9.4 6.3 4.5 7.3 0.1 3.5 4 0 0 4 4 4 0 Putative quorum-sensing-regulated virulence factor ParcG PF10274.9 EFA74736.1 - 2.7 8.1 8.0 3.1 7.9 0.1 4.8 4 0 0 4 4 4 0 Parkin co-regulated protein BHD_3 PF10405.9 EFA74739.1 - 7.7e-22 77.5 0.1 2.1e-21 76.1 0.1 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EFA74739.1 - 8.1e-10 38.4 0.6 2.2e-09 37.0 0.2 2.1 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 EFA74739.1 - 3.6e-09 36.5 27.8 3.6e-09 36.5 27.8 6.7 4 1 1 5 5 5 2 Rad4 transglutaminase-like domain BHD_2 PF10404.9 EFA74739.1 - 3e-06 28.1 3.9 3e-06 28.1 3.9 7.9 5 3 0 5 5 5 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EFA74739.1 - 0.029 14.8 0.0 0.2 12.1 0.0 2.4 2 0 0 2 2 2 0 Transglutaminase-like superfamily dCMP_cyt_deam_1 PF00383.23 EFA74740.1 - 7.1e-14 51.5 0.3 1.1e-13 50.9 0.3 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFA74740.1 - 1.1e-11 44.7 0.5 2.3e-11 43.6 0.5 1.5 1 1 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EFA74740.1 - 0.0013 18.8 0.3 0.0021 18.2 0.3 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 EFA74740.1 - 0.0046 17.0 2.3 0.76 9.8 0.4 2.2 1 1 1 2 2 2 2 Bd3614-like deaminase NAD1 PF18778.1 EFA74740.1 - 0.0051 16.9 0.2 0.0077 16.3 0.2 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 EFA74740.1 - 0.016 15.3 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 APOBEC3 APOBEC2 PF18772.1 EFA74740.1 - 0.05 13.6 0.3 0.069 13.2 0.3 1.2 1 0 0 1 1 1 0 APOBEC2 FNIP PF05725.12 EFA74741.1 - 1.2e-13 51.0 12.9 6.3e-08 32.7 2.7 5.0 3 2 1 4 4 4 4 FNIP Repeat F-box_5 PF18511.1 EFA74741.1 - 6.5e-05 22.4 0.1 0.00012 21.6 0.1 1.4 1 0 0 1 1 1 1 F-box LRR_5 PF13306.6 EFA74741.1 - 1.2 9.1 6.8 0.75 9.8 1.8 2.7 2 1 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) G8 PF10162.9 EFA74742.1 - 5.3e-23 81.4 0.1 2.8e-22 79.1 0.0 2.2 2 0 0 2 2 2 1 G8 domain Amnionless PF14828.6 EFA74742.1 - 0.15 10.8 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Amnionless Adaptin_N PF01602.20 EFA74743.1 - 1.2e-110 370.6 2.8 2.2e-110 369.7 2.8 1.4 1 1 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EFA74743.1 - 3e-28 98.3 0.0 1e-27 96.6 0.0 2.0 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EFA74743.1 - 1.3e-19 70.5 0.5 4e-19 69.0 0.5 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.6 EFA74743.1 - 0.00064 20.1 0.7 0.26 11.7 0.0 3.0 3 0 0 3 3 3 2 HEAT repeats AP4E_app_platf PF14807.6 EFA74743.1 - 0.047 14.0 0.0 0.94 9.9 0.0 2.4 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform B2-adapt-app_C PF09066.10 EFA74743.1 - 0.073 13.2 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain DUF948 PF06103.11 EFA74744.1 - 0.056 13.7 2.3 0.19 12.0 2.3 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF948 PF06103.11 EFA74745.1 - 0.078 13.2 2.0 0.11 12.8 2.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) PH PF00169.29 EFA74746.1 - 4.2e-09 36.9 0.8 2.9e-08 34.2 0.8 2.4 1 1 0 1 1 1 1 PH domain EGF_2 PF07974.13 EFA74747.1 - 0.056 13.8 3.3 0.16 12.4 3.3 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA74748.1 - 0.007 16.7 2.8 0.021 15.2 2.8 1.9 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 EFA74748.1 - 1.4 9.1 5.2 0.24 11.6 0.5 2.1 2 0 0 2 2 2 0 Laminin EGF domain ACP53EA PF06313.11 EFA74749.1 - 0.054 13.7 0.1 3.3 8.0 0.0 2.6 2 0 0 2 2 2 0 Drosophila ACP53EA protein Ribosomal_L34e PF01199.18 EFA74750.1 - 4.5e-33 113.4 18.4 1.9e-27 95.4 2.6 2.8 3 0 0 3 3 3 2 Ribosomal protein L34e Nkap_C PF06047.11 EFA74750.1 - 0.37 10.9 3.2 3.1 8.0 3.2 2.1 1 1 0 1 1 1 0 NF-kappa-B-activating protein C-terminal domain Glyco_transf_10 PF00852.19 EFA74751.1 - 5.9e-21 75.0 0.6 1.5e-20 73.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term NMN_transporter PF04973.12 EFA74751.1 - 0.056 13.4 1.5 0.086 12.8 0.3 1.7 2 0 0 2 2 2 0 Nicotinamide mononucleotide transporter WD40 PF00400.32 EFA74752.1 - 4.7e-20 71.5 9.3 9.3e-07 29.5 0.3 6.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA74752.1 - 2.4e-06 27.8 0.9 0.4 11.0 0.0 4.1 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA74752.1 - 3.8e-05 23.2 2.3 0.021 14.1 0.8 3.4 2 1 1 3 3 3 2 WD40-like domain BBS2_Mid PF14783.6 EFA74752.1 - 0.00068 19.7 0.0 8 6.5 0.0 3.7 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region EGF_2 PF07974.13 EFA74753.1 - 0.064 13.6 0.4 0.064 13.6 0.4 5.6 4 2 1 5 5 5 0 EGF-like domain G_glu_transpept PF01019.21 EFA74754.1 - 3.5e-92 309.8 0.0 4.5e-92 309.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 EFA74755.1 - 1.3e-35 123.1 0.0 1.5e-35 123.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 EFA74756.1 - 3.7e-110 369.1 0.0 1.5e-100 337.4 0.0 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase Pox_G7 PF05503.12 EFA74756.1 - 0.08 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus G7-like zf-H2C2_5 PF13909.6 EFA74757.1 - 0.0025 17.5 2.8 0.0067 16.2 2.8 1.8 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 EFA74757.1 - 0.011 16.4 1.8 0.033 14.9 1.8 1.9 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats VWA_N2 PF16164.5 EFA74757.1 - 0.064 13.4 1.0 0.21 11.8 0.4 2.2 2 0 0 2 2 2 0 VWA N-terminal zf-C2H2 PF00096.26 EFA74757.1 - 0.12 12.9 1.8 0.63 10.6 1.8 2.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFA74757.1 - 0.19 12.7 5.5 0.065 14.1 1.6 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFA74757.1 - 0.29 11.6 2.3 30 5.3 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger double domain Mitofilin PF09731.9 EFA74757.1 - 0.33 9.7 6.7 0.47 9.2 6.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FAM104 PF15434.6 EFA74757.1 - 0.52 10.9 10.5 1.2 9.7 9.6 2.2 1 1 0 1 1 1 0 Family 104 SR-25 PF10500.9 EFA74757.1 - 0.68 9.5 14.3 2.2 7.9 14.3 1.8 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TROVE PF05731.11 EFA74759.1 - 1.5e-87 294.5 3.6 4e-81 273.3 3.8 3.3 1 1 1 2 2 2 2 TROVE domain WD40 PF00400.32 EFA74759.1 - 4.8e-86 280.4 62.4 5.5e-09 36.5 0.6 19.0 19 0 0 19 19 18 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA74759.1 - 7.1e-31 106.4 6.7 2.4e-05 24.5 0.2 10.9 5 2 4 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain DUF4062 PF13271.6 EFA74759.1 - 2.8e-18 66.1 0.0 4.2e-17 62.3 0.0 3.0 3 0 0 3 3 2 1 Domain of unknown function (DUF4062) WD40_like PF17005.5 EFA74759.1 - 2.1e-14 53.6 15.4 0.00035 20.0 0.7 7.8 7 2 1 8 8 8 4 WD40-like domain eIF2A PF08662.11 EFA74759.1 - 4.5e-09 36.5 12.3 0.057 13.3 0.2 6.1 4 1 2 6 6 6 4 Eukaryotic translation initiation factor eIF2A APAF1_C PF17908.1 EFA74759.1 - 7.3e-08 32.5 5.6 1.1e-07 31.9 1.0 3.4 3 1 0 3 3 3 1 APAF-1 helical domain NACHT PF05729.12 EFA74759.1 - 2.4e-07 30.8 0.1 6e-07 29.5 0.1 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFA74759.1 - 9.5e-07 29.2 0.0 3.8e-06 27.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain Ge1_WD40 PF16529.5 EFA74759.1 - 1.5e-05 24.1 26.6 1.3 7.9 0.2 10.5 5 3 1 9 9 9 3 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_16 PF13191.6 EFA74759.1 - 7.1e-05 23.3 3.5 0.00021 21.7 0.5 3.3 2 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EFA74759.1 - 0.00099 19.1 0.0 0.00099 19.1 0.0 1.9 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EFA74759.1 - 0.016 14.5 3.6 0.017 14.4 0.0 2.8 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 EFA74759.1 - 0.035 14.6 0.1 0.18 12.3 0.0 2.4 2 0 0 2 2 1 0 ABC transporter DUF4306 PF14154.6 EFA74759.1 - 0.059 13.5 0.3 0.26 11.5 0.1 2.2 2 0 0 2 2 1 0 Domain of unknown function (DUF4306) NB-ARC PF00931.22 EFA74759.1 - 0.06 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 EFA74759.1 - 0.094 12.4 0.0 0.4 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA74759.1 - 0.1 11.9 0.0 0.87 8.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF29 PF01724.16 EFA74759.1 - 0.27 11.5 2.2 0.6 10.3 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF29 DivIC PF04977.15 EFA74759.1 - 9.6 6.1 8.2 2.7 7.8 1.9 2.9 2 0 0 2 2 2 0 Septum formation initiator Lipase_GDSL PF00657.22 EFA74760.1 - 0.0013 18.8 0.0 0.0063 16.5 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PSI_PSAK PF01241.18 EFA74760.1 - 0.13 12.3 0.2 0.3 11.1 0.2 1.5 1 0 0 1 1 1 0 Photosystem I psaG / psaK Sin_N PF04801.13 EFA74761.1 - 6.2e-82 276.1 12.0 7.7e-75 252.7 5.8 2.6 1 1 1 2 2 2 2 Sin-like protein conserved region PrmC_N PF17827.1 EFA74762.1 - 1.9e-12 47.6 0.0 5.6e-12 46.1 0.0 1.8 2 0 0 2 2 2 1 PrmC N-terminal domain MTS PF05175.14 EFA74762.1 - 4.6e-11 42.6 0.4 3.6e-10 39.6 0.4 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EFA74762.1 - 1.8e-09 37.6 0.2 5e-09 36.1 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA74762.1 - 3.2e-07 30.3 0.0 1.1e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA74762.1 - 5.8e-07 30.1 0.0 1.4e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA74762.1 - 3e-05 24.7 0.0 3e-05 24.7 0.0 3.0 3 1 1 4 4 3 1 Methyltransferase domain Rsm22 PF09243.10 EFA74762.1 - 0.04 13.2 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_16 PF10294.9 EFA74762.1 - 0.05 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 EFA74762.1 - 0.11 11.9 1.3 0.29 10.5 1.3 1.7 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EFA74762.1 - 0.12 13.1 0.0 0.24 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 EFA74762.1 - 0.12 12.1 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PQ-loop PF04193.14 EFA74763.1 - 1.3e-17 63.3 23.9 3.7e-09 36.2 2.1 4.1 3 1 1 4 4 4 3 PQ loop repeat Diphthami_syn_2 PF01902.17 EFA74764.1 - 5.6e-39 133.9 0.0 1.2e-38 132.8 0.0 1.5 1 0 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EFA74764.1 - 1.3e-18 67.1 0.0 3e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Endoribonuclease L-PSP VPS9 PF02204.18 EFA74764.1 - 0.03 14.5 1.7 6 7.1 0.0 3.7 3 1 0 3 3 3 0 Vacuolar sorting protein 9 (VPS9) domain Sod_Cu PF00080.20 EFA74765.1 - 3.4e-16 59.7 0.0 6.2e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.20 EFA74766.1 - 8.3e-16 58.4 0.0 8.8e-12 45.4 0.0 2.2 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) PI3_PI4_kinase PF00454.27 EFA74767.1 - 1.2e-54 185.8 0.4 1.2e-54 185.8 0.4 3.7 2 2 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFA74767.1 - 4.8e-23 81.5 0.5 4.8e-23 81.5 0.5 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_rbd PF00794.18 EFA74767.1 - 2.8e-06 27.5 1.6 6.7e-06 26.2 0.0 2.5 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain Abhydrolase_1 PF00561.20 EFA74768.1 - 9.2e-15 55.0 0.0 1.9e-13 50.7 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EFA74768.1 - 4.7e-12 46.1 0.1 9.8e-12 45.1 0.1 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFA74768.1 - 7.5e-12 46.3 0.0 1.5e-11 45.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA74768.1 - 1.7e-11 43.9 0.0 3e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EFA74768.1 - 0.00013 21.6 0.1 0.00027 20.5 0.1 1.7 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EFA74768.1 - 0.0009 19.1 0.1 0.0027 17.6 0.0 2.0 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_5 PF12695.7 EFA74768.1 - 0.0024 17.7 0.0 0.0082 15.9 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydro_lipase PF04083.16 EFA74768.1 - 0.0036 16.8 0.1 0.015 14.8 0.0 2.1 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Ndr PF03096.14 EFA74768.1 - 0.0087 14.8 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Ndr family Esterase PF00756.20 EFA74768.1 - 0.017 14.8 0.0 0.051 13.2 0.0 1.8 1 1 0 1 1 1 0 Putative esterase Ser_hydrolase PF06821.13 EFA74768.1 - 0.034 14.0 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase Chlorophyllase PF07224.11 EFA74768.1 - 0.075 12.0 0.0 0.27 10.2 0.0 1.8 1 1 0 1 1 1 0 Chlorophyllase CDC45 PF02724.14 EFA74768.1 - 2 6.6 14.5 2.9 6.1 14.5 1.2 1 0 0 1 1 1 0 CDC45-like protein CLN5 PF15014.6 EFA74769.1 - 4e-31 108.8 11.3 3.2e-28 99.3 2.1 2.1 1 1 1 2 2 2 2 Ceroid-lipofuscinosis neuronal protein 5 DUF4430 PF14478.6 EFA74769.1 - 0.23 12.1 0.4 0.23 12.1 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4430) FMO-like PF00743.19 EFA74770.1 - 3.3e-61 207.3 0.0 4.1e-61 207.0 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFA74770.1 - 6.7e-16 58.4 0.0 4.5e-13 49.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA74770.1 - 1.6e-10 40.7 0.0 6.2e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA74770.1 - 0.0001 22.8 0.0 0.047 14.3 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFA74770.1 - 0.00019 20.7 0.1 0.0013 18.0 0.0 2.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFA74770.1 - 0.00098 19.3 0.0 0.0044 17.2 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFA74770.1 - 0.0017 18.4 0.0 0.41 10.6 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EFA74770.1 - 0.0083 14.9 0.0 0.015 14.0 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EFA74770.1 - 0.01 15.4 0.1 0.55 9.8 0.1 2.7 2 1 0 3 3 3 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFA74770.1 - 0.033 13.3 0.1 0.05 12.7 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain CBM_14 PF01607.24 EFA74772.1 - 2.7e-07 30.6 9.1 6.8e-07 29.4 9.1 1.7 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain Ank_4 PF13637.6 EFA74772.1 - 0.00015 22.2 0.1 1.1 10.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA74772.1 - 0.00029 21.4 0.3 0.24 12.0 0.0 3.0 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA74772.1 - 0.00055 20.2 0.1 50 5.0 0.0 5.2 5 0 0 5 5 5 0 Ankyrin repeat Acyl_transf_1 PF00698.21 EFA74774.1 - 0.0094 15.5 0.0 0.0094 15.5 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain zf-C3HC4_3 PF13920.6 EFA74775.1 - 7.7e-09 35.3 10.8 1.5e-08 34.4 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA74775.1 - 9.1e-08 31.8 10.1 2e-07 30.7 10.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA74775.1 - 3.2e-06 26.9 10.6 7e-06 25.8 10.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFA74775.1 - 3.5e-06 26.8 12.8 9.2e-06 25.4 12.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA74775.1 - 9.7e-05 22.6 11.4 0.00022 21.5 11.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA74775.1 - 0.00053 20.0 10.2 0.0012 18.8 10.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA74775.1 - 0.0014 18.5 12.0 0.0042 17.0 12.0 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 EFA74775.1 - 0.0029 17.4 3.2 0.0058 16.5 3.2 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EFA74775.1 - 0.0055 17.0 7.0 0.022 15.1 7.0 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain DivIC PF04977.15 EFA74775.1 - 0.011 15.5 0.7 0.011 15.5 0.7 9.2 7 2 3 10 10 10 0 Septum formation initiator DegS PF05384.11 EFA74775.1 - 0.011 15.2 9.8 0.011 15.2 9.8 6.4 3 1 3 7 7 5 0 Sensor protein DegS zf-RING_4 PF14570.6 EFA74775.1 - 0.054 13.3 9.5 0.11 12.3 9.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EFA74775.1 - 0.075 13.1 3.2 0.15 12.1 3.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EFA74775.1 - 0.12 12.6 8.6 0.32 11.2 8.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EFA74775.1 - 4.3 7.2 9.0 6.1 6.7 6.5 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit SUI1 PF01253.22 EFA74776.1 - 2.3e-24 85.7 0.1 2.9e-24 85.4 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Choline_kinase PF01633.20 EFA74777.1 - 1.3e-62 211.2 0.0 2.8e-62 210.1 0.0 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFA74777.1 - 9e-13 48.7 0.0 1.9e-12 47.7 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFA74777.1 - 0.0063 15.9 0.0 0.021 14.2 0.0 1.7 1 1 1 2 2 2 1 Ecdysteroid kinase Kdo PF06293.14 EFA74777.1 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RhoGAP PF00620.27 EFA74778.1 - 1.1e-33 116.2 0.4 4.1e-33 114.4 0.4 2.0 1 0 0 1 1 1 1 RhoGAP domain DUF2397 PF09660.10 EFA74778.1 - 0.72 8.7 4.4 1.1 8.0 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) PBP1_TM PF14812.6 EFA74778.1 - 1.5 9.3 4.2 8.1 6.9 3.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.25 EFA74779.1 - 3.1e-51 174.3 0.0 1e-36 126.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74779.1 - 5.9e-20 71.6 0.1 7.5e-12 45.1 0.0 2.7 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA74779.1 - 0.00027 20.4 0.1 0.44 9.8 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Glyco_hydro_20 PF00728.22 EFA74780.1 - 3.1e-84 283.4 2.7 6.6e-84 282.3 2.7 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFA74780.1 - 1.9e-13 51.2 0.1 1.3e-12 48.6 0.1 2.3 2 1 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFA74780.1 - 0.029 15.1 0.0 0.062 14.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 zn-ribbon_14 PF16503.5 EFA74782.1 - 0.0039 16.7 1.6 0.0088 15.5 1.6 1.6 1 0 0 1 1 1 1 Zinc-ribbon Acetyltransf_1 PF00583.25 EFA74783.1 - 0.0034 17.6 0.0 0.0049 17.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA74783.1 - 0.02 15.3 0.0 0.035 14.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EFA74784.1 - 1.1e-44 152.8 5.3 1.1e-44 152.8 5.3 3.5 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74784.1 - 3.4e-17 62.6 0.1 5.7e-15 55.3 0.1 2.8 1 1 0 1 1 1 1 Protein tyrosine kinase MMR_HSR1 PF01926.23 EFA74784.1 - 0.032 14.3 0.2 1 9.5 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase DHHC PF01529.20 EFA74786.1 - 5.7e-16 58.8 36.6 1.2e-13 51.4 15.4 3.4 2 1 1 3 3 3 2 DHHC palmitoyltransferase DUF2207 PF09972.9 EFA74786.1 - 0.052 12.3 0.6 0.21 10.3 0.5 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Spt4 PF06093.13 EFA74786.1 - 1.2 9.3 5.7 2.8 8.1 5.7 1.7 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger LAP1C PF05609.12 EFA74786.1 - 5.4 6.0 12.8 2.6 7.0 10.4 1.6 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Amidinotransf PF02274.17 EFA74788.1 - 8.1e-51 173.1 3.5 2.5e-34 118.9 0.0 4.1 2 2 0 3 3 3 3 Amidinotransferase Thr_synth_N PF14821.6 EFA74789.1 - 2e-28 98.4 0.0 6e-28 96.9 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EFA74789.1 - 6.6e-20 71.7 0.0 5.9e-19 68.6 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3870 PF12986.7 EFA74790.1 - 0.029 14.6 0.5 0.18 12.0 0.5 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) TFCD_C PF12612.8 EFA74790.1 - 0.051 13.4 6.9 1.1 9.1 0.9 3.6 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal FliS PF02561.14 EFA74790.1 - 1.1 9.5 4.2 1.1 9.5 0.6 2.9 2 1 1 3 3 3 0 Flagellar protein FliS Mucin PF01456.17 EFA74791.1 - 0.0053 16.8 23.5 0.0053 16.8 23.5 1.9 2 0 0 2 2 2 1 Mucin-like glycoprotein Esterase_phd PF10503.9 EFA74791.1 - 0.011 15.3 0.0 0.023 14.2 0.0 1.6 1 0 0 1 1 1 0 Esterase PHB depolymerase SprA-related PF12118.8 EFA74791.1 - 5.9 5.9 11.0 9.1 5.3 11.0 1.2 1 0 0 1 1 1 0 SprA-related family MMR_HSR1 PF01926.23 EFA74792.1 - 2.6e-16 59.7 0.1 6.9e-07 29.4 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AIG1 PF04548.16 EFA74792.1 - 8.2e-11 41.6 0.2 1.5e-05 24.4 0.0 4.4 4 0 0 4 4 4 2 AIG1 family RNA_helicase PF00910.22 EFA74792.1 - 4.2e-05 23.9 0.3 0.37 11.2 0.0 3.0 2 0 0 2 2 2 2 RNA helicase NB-ARC PF00931.22 EFA74792.1 - 9.9e-05 21.6 5.8 0.11 11.7 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain AAA_17 PF13207.6 EFA74792.1 - 0.00013 22.4 0.0 0.027 14.9 0.0 4.9 4 2 0 4 4 2 2 AAA domain SRPRB PF09439.10 EFA74792.1 - 0.00089 18.7 6.3 0.025 14.0 0.0 2.9 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit AAA PF00004.29 EFA74792.1 - 0.0016 18.9 5.0 0.67 10.4 0.0 3.7 3 2 2 5 5 5 2 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFA74792.1 - 0.0024 18.4 22.7 0.23 12.0 0.0 4.4 4 0 0 4 4 4 2 ABC transporter KAP_NTPase PF07693.14 EFA74792.1 - 0.0087 15.3 0.0 4.8 6.3 0.0 2.6 2 2 0 2 2 2 2 KAP family P-loop domain RsgA_GTPase PF03193.16 EFA74792.1 - 0.013 15.4 14.6 0.14 12.0 0.0 4.4 4 2 0 4 4 4 0 RsgA GTPase AAA_29 PF13555.6 EFA74792.1 - 0.03 14.1 0.0 10 5.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EFA74792.1 - 0.046 13.5 3.6 3.5 7.3 0.1 3.1 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EFA74792.1 - 0.046 13.9 0.5 6.9 6.9 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFA74792.1 - 0.091 12.5 0.7 17 5.1 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EFA74792.1 - 0.43 10.8 12.7 1.6 9.0 0.0 4.4 4 1 0 5 5 5 0 AAA domain AAA_16 PF13191.6 EFA74792.1 - 0.65 10.4 0.0 0.65 10.4 0.0 4.5 3 2 0 3 3 3 0 AAA ATPase domain Fer4_NifH PF00142.18 EFA74792.1 - 1.3 8.4 7.1 5.2 6.4 0.1 3.0 3 0 0 3 3 3 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CbiA PF01656.23 EFA74792.1 - 3.6 7.6 11.8 13 5.8 0.1 4.7 4 2 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF4670 PF15709.5 EFA74792.1 - 7.3 5.8 70.3 0.87 8.8 34.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4670) MMR_HSR1 PF01926.23 EFA74793.1 - 3.6e-08 33.5 0.3 1.1e-07 32.0 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA74793.1 - 3e-06 26.7 0.0 3e-06 26.7 0.0 1.9 2 1 1 3 3 3 1 AIG1 family ABC_tran PF00005.27 EFA74793.1 - 0.0032 18.0 4.4 0.044 14.3 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 EFA74793.1 - 0.022 15.2 0.0 0.022 15.2 0.0 2.8 2 1 1 3 3 3 0 AAA domain Dynamin_N PF00350.23 EFA74793.1 - 0.061 13.4 0.0 0.061 13.4 0.0 3.3 2 2 2 4 4 4 0 Dynamin family RsgA_GTPase PF03193.16 EFA74793.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.5 2 1 1 3 3 3 0 RsgA GTPase RNase_HII PF01351.18 EFA74793.1 - 4.1 7.2 9.4 25 4.6 0.0 2.3 1 1 0 2 2 2 0 Ribonuclease HII MAP7 PF05672.11 EFA74793.1 - 6 6.5 35.5 8.6 6.0 35.5 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Pkinase PF00069.25 EFA74794.1 - 9.1e-28 97.3 0.0 2.7e-27 95.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74794.1 - 9.1e-15 54.6 0.0 1.9e-13 50.3 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Rhodanese PF00581.20 EFA74794.1 - 1.4e-07 32.0 0.0 4.6e-06 27.1 0.0 2.9 2 1 0 2 2 2 1 Rhodanese-like domain BUD22 PF09073.10 EFA74794.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 BUD22 CutC PF03932.14 EFA74795.1 - 4e-66 222.3 0.4 4.9e-66 222.1 0.4 1.1 1 0 0 1 1 1 1 CutC family AP_endonuc_2 PF01261.24 EFA74795.1 - 0.015 14.7 0.0 0.32 10.4 0.0 2.1 1 1 0 2 2 2 0 Xylose isomerase-like TIM barrel DUF2807 PF10988.8 EFA74795.1 - 0.057 13.2 0.4 0.099 12.4 0.4 1.4 1 0 0 1 1 1 0 Putative auto-transporter adhesin, head GIN domain KDGP_aldolase PF07071.11 EFA74795.1 - 0.072 12.9 1.1 1.7 8.4 0.5 2.5 1 1 2 3 3 3 0 KDGP aldolase SUZ PF12752.7 EFA74796.1 - 0.00031 21.4 0.1 0.00031 21.4 0.1 4.7 3 1 1 4 4 4 1 SUZ domain SPX PF03105.19 EFA74797.1 - 1.6e-05 25.0 17.9 0.029 14.3 0.0 2.4 1 1 1 2 2 2 2 SPX domain Spt20 PF12090.8 EFA74797.1 - 0.0012 18.5 18.1 0.0012 18.5 18.1 3.7 4 1 0 4 4 4 1 Spt20 family Androgen_recep PF02166.16 EFA74797.1 - 0.0016 17.4 21.3 0.027 13.3 10.4 2.2 2 0 0 2 2 2 2 Androgen receptor Pex26 PF07163.12 EFA74797.1 - 8.3 5.6 33.9 1.6 7.9 0.0 4.9 2 2 2 4 4 4 0 Pex26 protein EGF_2 PF07974.13 EFA74798.1 - 0.0029 17.9 13.3 0.0029 17.9 13.3 2.3 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EFA74798.1 - 0.51 10.7 9.1 1.5 9.2 9.1 1.8 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA74798.1 - 0.51 11.0 7.2 1.9 9.2 7.2 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.13 EFA74799.1 - 0.0017 18.7 17.7 0.0029 17.9 13.3 2.4 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EFA74799.1 - 3.7 8.0 15.1 1.5 9.2 9.1 2.6 2 0 0 2 2 2 0 EGF-like domain RasGEF PF00617.19 EFA74800.1 - 1.7e-40 139.1 0.1 1.7e-40 139.1 0.1 3.4 3 0 0 3 3 3 1 RasGEF domain GRAM PF02893.20 EFA74800.1 - 3.6e-14 52.6 1.0 1.1e-13 51.0 1.0 1.9 1 0 0 1 1 1 1 GRAM domain RhoGAP PF00620.27 EFA74800.1 - 3e-08 33.6 0.0 1.4e-07 31.5 0.0 2.2 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.20 EFA74800.1 - 8.6e-05 22.7 0.6 8.6e-05 22.7 0.6 5.9 5 1 0 5 5 5 1 RasGEF N-terminal motif Lyase_1 PF00206.20 EFA74801.1 - 3.2e-51 174.6 0.0 4.2e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 EFA74801.1 - 1.9e-46 156.9 0.0 4.3e-46 155.7 0.0 1.6 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal Y_phosphatase2 PF03162.13 EFA74802.1 - 1.1e-12 47.8 0.0 1.5e-10 40.9 0.0 2.7 2 0 0 2 2 2 1 Tyrosine phosphatase family Presenilin PF01080.17 EFA74802.1 - 0.75 8.5 9.7 0.049 12.4 4.8 1.6 2 0 0 2 2 2 0 Presenilin GREB1 PF15782.5 EFA74802.1 - 2 5.4 16.4 3.1 4.8 16.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 EFA74802.1 - 8.4 5.0 22.2 0.34 9.5 16.2 1.6 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Peptidase_S30 PF01577.16 EFA74802.1 - 9.2 5.8 13.7 7.1 6.2 0.1 2.2 2 0 0 2 2 2 0 Potyvirus P1 protease IBN_N PF03810.19 EFA74804.1 - 6.9e-12 45.1 1.5 4e-11 42.7 0.5 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain CLASP_N PF12348.8 EFA74804.1 - 0.0053 16.3 0.2 0.016 14.8 0.2 1.8 1 0 0 1 1 1 1 CLASP N terminal Papo_T_antigen PF02380.15 EFA74805.1 - 0.11 12.7 1.8 0.19 11.9 1.8 1.4 1 1 0 1 1 1 0 T-antigen specific domain Ras PF00071.22 EFA74806.1 - 4.4e-59 198.7 0.0 5.1e-59 198.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA74806.1 - 1.1e-20 74.0 0.0 1.5e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA74806.1 - 2.1e-09 37.1 0.0 2.5e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA74806.1 - 4.6e-06 26.3 0.2 3.2e-05 23.6 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA74806.1 - 8.5e-05 22.6 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA74806.1 - 0.00012 22.0 0.2 0.53 10.2 0.0 2.5 1 1 2 3 3 3 2 RsgA GTPase ATP_bind_1 PF03029.17 EFA74806.1 - 0.0077 16.0 0.8 0.083 12.7 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 EFA74806.1 - 0.042 13.1 0.0 0.071 12.4 0.0 1.4 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 EFA74806.1 - 0.047 13.2 0.0 0.24 10.9 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B ParA PF10609.9 EFA74806.1 - 0.19 11.2 0.2 0.78 9.1 0.1 1.8 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase zf-B_box PF00643.24 EFA74807.1 - 1.2e-06 28.6 8.0 1.2e-06 28.6 8.0 2.1 2 0 0 2 2 2 1 B-box zinc finger Kelch_6 PF13964.6 EFA74807.1 - 7.3e-06 26.1 4.4 0.00039 20.6 0.2 3.7 3 0 0 3 3 3 1 Kelch motif DUF2457 PF10446.9 EFA74807.1 - 0.71 9.0 14.7 1.1 8.3 14.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Mucin PF01456.17 EFA74808.1 - 3.8 7.5 13.2 0.4 10.7 8.3 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein Lipase_3 PF01764.25 EFA74809.1 - 2.5e-34 118.2 0.0 3.8e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Cutinase PF01083.22 EFA74809.1 - 0.00053 20.0 1.9 0.0032 17.4 1.0 2.5 2 2 0 2 2 2 1 Cutinase CBM_14 PF01607.24 EFA74810.1 - 0.00024 21.2 3.1 0.00024 21.2 3.1 2.5 2 1 0 2 2 2 1 Chitin binding Peritrophin-A domain Ank_2 PF12796.7 EFA74811.1 - 3.2e-36 123.8 10.6 1.3e-10 41.7 0.1 6.7 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA74811.1 - 2.7e-31 107.5 14.9 2e-06 28.2 0.0 10.1 5 4 4 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74811.1 - 6.3e-25 84.5 7.5 0.55 11.0 0.0 14.1 14 2 2 16 16 16 4 Ankyrin repeat Ank_5 PF13857.6 EFA74811.1 - 9.2e-25 86.4 11.5 0.043 14.2 0.0 11.3 4 2 8 13 13 13 10 Ankyrin repeats (many copies) FBD PF08387.10 EFA74811.1 - 0.00034 20.4 0.3 2.2 8.2 0.0 4.4 3 0 0 3 3 3 1 FBD Ank PF00023.30 EFA74811.1 - 0.00054 20.3 4.7 5 7.8 0.0 6.2 6 2 1 7 7 7 1 Ankyrin repeat CNOT1_HEAT PF16418.5 EFA74811.1 - 0.024 14.7 0.4 2.3 8.3 0.0 3.9 5 1 1 6 6 6 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Tn7_Tnp_TnsA_C PF08721.11 EFA74811.1 - 0.03 14.9 1.6 22 5.7 0.1 4.2 3 1 1 4 4 4 0 TnsA endonuclease C terminal HHA PF05321.11 EFA74812.1 - 4.9e-05 23.6 1.3 0.00057 20.1 0.0 2.9 3 0 0 3 3 3 1 Haemolysin expression modulating protein MIEAP PF16026.5 EFA74812.1 - 0.006 16.8 1.9 0.013 15.7 1.9 1.5 1 0 0 1 1 1 1 Mitochondria-eating protein ComGG PF14173.6 EFA74812.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 ComG operon protein 7 DUF4746 PF15928.5 EFA74813.1 - 0.045 13.2 12.3 0.11 11.9 12.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RRM_1 PF00076.22 EFA74815.1 - 6e-48 160.6 2.9 4.9e-18 64.7 0.2 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA74815.1 - 6e-10 39.1 0.1 4.3e-06 26.8 0.1 3.6 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 EFA74815.1 - 1.8e-09 37.3 0.3 5e-07 29.3 0.3 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA74815.1 - 1.6e-05 24.8 0.1 0.036 14.1 0.0 3.0 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EFA74815.1 - 0.00014 21.9 2.1 0.0064 16.5 0.2 2.8 2 2 0 2 2 2 1 RNA binding motif RRM_occluded PF16842.5 EFA74815.1 - 0.00035 20.4 0.0 5 7.1 0.0 3.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EFA74815.1 - 0.0027 18.0 11.3 0.2 11.9 0.0 5.6 2 2 3 5 5 5 1 Cytosolic domain of 10TM putative phosphate transporter BRAP2 PF07576.12 EFA74815.1 - 0.0048 17.1 0.1 1.4 9.2 0.0 2.6 2 0 0 2 2 2 1 BRCA1-associated protein 2 SNF2_N PF00176.23 EFA74816.1 - 1.6e-58 198.1 5.1 1.6e-58 198.1 5.1 2.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA74816.1 - 2.3e-18 66.5 0.9 1.7e-17 63.7 0.0 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Rad60-SLD PF11976.8 EFA74816.1 - 2.4e-18 65.7 6.2 0.00089 19.0 0.0 6.5 5 0 0 5 5 5 4 Ubiquitin-2 like Rad60 SUMO-like Chromo PF00385.24 EFA74816.1 - 9e-11 41.5 0.1 3.7e-10 39.6 0.1 2.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ubiquitin PF00240.23 EFA74816.1 - 2.8e-05 23.8 0.7 1.5 8.6 0.0 6.1 5 0 0 5 5 5 1 Ubiquitin family SLIDE PF09111.10 EFA74816.1 - 0.0019 18.2 0.0 0.0019 18.2 0.0 5.0 4 0 0 4 4 4 1 SLIDE CHDCT2 PF08074.11 EFA74816.1 - 0.33 11.1 0.0 0.33 11.1 0.0 6.8 6 1 0 6 6 6 0 CHDCT2 (NUC038) domain HMG_CoA_synt_C PF08540.10 EFA74817.1 - 1.5e-98 329.9 5.2 2e-98 329.5 5.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EFA74817.1 - 1.5e-86 288.7 0.5 2.3e-86 288.1 0.5 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal LSM PF01423.22 EFA74818.1 - 6e-12 45.1 1.3 8.5e-12 44.6 1.3 1.1 1 0 0 1 1 1 1 LSM domain WD40 PF00400.32 EFA74819.1 - 8e-62 203.7 27.3 1.9e-10 41.1 0.9 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA74819.1 - 1.2e-18 67.1 2.1 6.3e-06 26.4 0.0 4.7 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA74819.1 - 9.6e-11 41.0 5.1 0.054 12.1 0.0 5.6 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFA74819.1 - 3.9e-05 22.8 6.0 0.29 10.0 0.0 4.2 1 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EFA74819.1 - 8.3e-05 21.5 0.5 0.055 12.2 0.0 3.3 3 1 1 4 4 4 2 Nup133 N terminal like LisH PF08513.11 EFA74819.1 - 0.0015 18.4 0.0 0.0027 17.6 0.0 1.5 1 0 0 1 1 1 1 LisH DASH_Spc19 PF08287.11 EFA74819.1 - 0.051 13.5 0.2 0.088 12.7 0.2 1.3 1 0 0 1 1 1 0 Spc19 EGF_2 PF07974.13 EFA74820.1 - 0.00043 20.6 12.7 0.00091 19.6 12.7 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA74820.1 - 0.64 10.1 14.3 1.7 8.8 14.3 1.7 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 EFA74820.1 - 1.2 9.5 6.5 2.6 8.4 6.5 1.6 1 0 0 1 1 1 0 EGF-like domain RasGEF PF00617.19 EFA74821.1 - 3.2e-55 187.1 0.6 8.6e-55 185.7 0.6 1.8 1 0 0 1 1 1 1 RasGEF domain tRNA-synt_2b PF00587.25 EFA74821.1 - 2.9e-29 102.3 0.0 1.1e-28 100.4 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF1084 PF06454.11 EFA74821.1 - 1.9e-13 50.4 18.7 3.4e-13 49.6 18.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) Seryl_tRNA_N PF02403.22 EFA74821.1 - 6.4e-12 45.7 9.9 1.6e-11 44.4 9.9 1.7 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain GRDP-like PF07173.12 EFA74821.1 - 0.37 11.4 4.6 1.1 10.0 4.6 1.8 1 0 0 1 1 1 0 Glycine-rich domain-containing protein-like Methyltransf_11 PF08241.12 EFA74822.1 - 3.9e-20 72.3 0.0 6.7e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA74822.1 - 1.2e-19 70.7 0.0 2.2e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA74822.1 - 5.5e-18 65.5 0.0 9.2e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA74822.1 - 5e-13 48.9 0.0 7.3e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFA74822.1 - 4.8e-11 42.8 0.0 7.5e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA74822.1 - 5.8e-10 39.8 0.0 1.1e-09 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFA74822.1 - 3.7e-09 36.7 0.0 5.6e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 EFA74822.1 - 3.4e-07 30.0 0.0 5.5e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 EFA74822.1 - 7e-07 28.8 0.0 1.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Fibrillarin PF01269.17 EFA74822.1 - 8.2e-05 21.8 0.0 0.00014 21.0 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin Methyltransf_32 PF13679.6 EFA74822.1 - 0.0002 21.4 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFA74822.1 - 0.0004 19.9 0.0 0.00086 18.8 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase SHOCT PF09851.9 EFA74822.1 - 0.0061 16.3 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Short C-terminal domain Pox_MCEL PF03291.16 EFA74822.1 - 0.0076 15.4 0.0 0.038 13.1 0.0 1.9 2 0 0 2 2 2 1 mRNA capping enzyme TPMT PF05724.11 EFA74822.1 - 0.0085 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 EFA74822.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.5 1 1 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 EFA74822.1 - 0.043 13.4 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EFA74822.1 - 0.058 13.5 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EFA74822.1 - 0.086 12.5 0.0 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Herpes_glycoH_C PF17488.2 EFA74822.1 - 0.087 12.6 0.0 0.28 11.0 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus glycoprotein H C-terminal domain RRM_1 PF00076.22 EFA74823.1 - 9.1e-18 63.9 0.0 1.4e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_C1 PF00112.23 EFA74824.1 - 3.8e-81 272.3 5.0 4.7e-81 272.0 5.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA74824.1 - 1.9e-11 44.2 0.6 3.5e-11 43.4 0.6 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA74824.1 - 0.00047 19.1 2.7 0.12 11.1 0.5 2.1 2 0 0 2 2 2 2 Peptidase C1-like family PEPCK_ATP PF01293.20 EFA74826.1 - 2.7e-23 82.4 0.3 1.3e-11 43.9 0.1 2.7 2 1 0 2 2 2 2 Phosphoenolpyruvate carboxykinase Acetyltransf_9 PF13527.7 EFA74827.1 - 2.3e-21 76.2 0.0 1.6e-20 73.5 0.0 2.3 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Redoxin PF08534.10 EFA74828.1 - 9.8e-27 93.5 0.0 1.2e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin Inhibitor_I29 PF08246.12 EFA74829.1 - 8.1e-12 45.4 0.4 1.7e-11 44.4 0.4 1.5 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Podoplanin PF05808.11 EFA74829.1 - 0.0015 18.6 0.6 0.0033 17.5 0.6 1.5 1 0 0 1 1 1 1 Podoplanin Bacteriocin_IIc PF10439.9 EFA74829.1 - 0.2 11.8 5.2 0.35 11.0 5.2 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide VSP PF03302.13 EFA74829.1 - 4.6 6.0 5.5 6.2 5.6 5.5 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Peptidase_C1 PF00112.23 EFA74830.1 - 7.6e-36 124.2 3.3 1.9e-35 122.9 3.3 1.6 1 0 0 1 1 1 1 Papain family cysteine protease CAP PF00188.26 EFA74830.1 - 3e-05 24.8 1.9 3e-05 24.8 1.9 2.4 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Ibs_toxin PF13956.6 EFA74830.1 - 0.053 13.5 3.3 0.099 12.7 3.3 1.4 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system Trypan_PARP PF05887.11 EFA74830.1 - 0.22 11.5 1.6 0.54 10.2 1.6 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Inhibitor_I29 PF08246.12 EFA74831.1 - 1e-11 45.1 0.8 2.1e-11 44.1 0.8 1.6 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Podoplanin PF05808.11 EFA74831.1 - 0.0018 18.4 0.6 0.0033 17.6 0.6 1.4 1 0 0 1 1 1 1 Podoplanin Bacteriocin_IIc PF10439.9 EFA74831.1 - 0.2 11.8 5.2 0.34 11.0 5.2 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide VSP PF03302.13 EFA74831.1 - 4.6 6.0 5.5 6.2 5.6 5.5 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Peptidase_C1 PF00112.23 EFA74832.1 - 2.8e-47 161.6 5.5 4.5e-47 161.0 5.5 1.3 1 0 0 1 1 1 1 Papain family cysteine protease CAP PF00188.26 EFA74832.1 - 2.7e-05 25.0 1.1 2.7e-05 25.0 1.1 2.2 3 0 0 3 3 3 1 Cysteine-rich secretory protein family Peptidase_C39_2 PF13529.6 EFA74832.1 - 0.00077 20.0 0.2 0.0016 19.0 0.2 1.5 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C1_2 PF03051.15 EFA74832.1 - 0.0018 17.2 0.4 0.27 10.0 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Ibs_toxin PF13956.6 EFA74832.1 - 0.68 10.0 3.2 1.3 9.1 3.2 1.5 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system FSA_C PF10479.9 EFA74833.1 - 0.76 7.8 5.3 0.8 7.8 5.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ANAPC4_WD40 PF12894.7 EFA74834.1 - 2e-10 40.8 0.2 0.09 13.1 0.0 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA74834.1 - 5.1e-10 39.8 11.7 0.28 12.1 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat BBS2_Mid PF14783.6 EFA74834.1 - 9.9e-06 25.6 0.1 0.12 12.4 0.0 2.7 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region BBS1 PF14779.6 EFA74834.1 - 0.00061 19.3 0.2 0.0049 16.4 0.0 2.2 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 1 NAGLU PF05089.12 EFA74835.1 - 4.6e-142 472.9 8.6 6.8e-142 472.3 8.6 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 EFA74835.1 - 2.9e-53 181.1 4.9 7.6e-53 179.8 1.5 2.1 1 1 1 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 EFA74835.1 - 6e-21 74.0 0.0 1.5e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Pax2_C PF12403.8 EFA74835.1 - 0.071 13.2 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Paired-box protein 2 C terminal TNT PF14021.6 EFA74835.1 - 0.14 12.7 0.0 39 4.9 0.0 3.4 3 1 0 3 3 3 0 Tuberculosis necrotizing toxin NAGLU PF05089.12 EFA74836.1 - 4.3e-87 292.2 1.4 4.3e-87 292.2 1.4 1.8 2 1 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 EFA74836.1 - 3.8e-56 190.6 1.1 5.7e-56 190.0 1.1 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU PF05089.12 EFA74837.1 - 1.1e-21 77.1 4.6 1.8e-21 76.5 4.6 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_N PF12971.7 EFA74837.1 - 4e-21 74.6 0.1 7.3e-21 73.7 0.1 1.4 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Rap_GAP PF02145.15 EFA74838.1 - 3e-58 196.4 0.7 1.6e-57 194.1 0.4 2.0 2 0 0 2 2 2 1 Rap/ran-GAP Toxin_25 PF08095.11 EFA74838.1 - 0.44 10.5 1.7 1.2 9.2 1.7 1.7 1 0 0 1 1 1 0 Hefutoxin family Mog1 PF04603.12 EFA74839.1 - 2.5e-40 138.0 0.2 3.9e-40 137.4 0.2 1.3 1 0 0 1 1 1 1 Ran-interacting Mog1 protein EF-hand_1 PF00036.32 EFA74842.1 - 3.3e-19 66.9 3.2 2.6e-06 26.6 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFA74842.1 - 1.4e-17 62.0 2.4 1.4e-05 24.7 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EFA74842.1 - 7e-16 58.4 4.9 3.1e-09 37.2 0.4 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA74842.1 - 5.7e-12 45.3 3.8 8.1e-07 28.8 0.4 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA74842.1 - 2.5e-10 39.4 7.3 0.0001 21.7 0.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.6 EFA74842.1 - 0.0022 17.8 1.4 0.77 9.7 0.1 2.4 2 0 0 2 2 2 2 EF hand Dockerin_1 PF00404.18 EFA74842.1 - 0.0034 17.5 2.1 0.25 11.6 0.3 2.6 2 1 0 2 2 2 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 EFA74842.1 - 0.0047 17.2 2.0 0.13 12.6 0.2 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Toprim_2 PF13155.6 EFA74842.1 - 0.017 15.5 0.8 0.35 11.3 0.1 2.3 2 1 0 2 2 2 0 Toprim-like Caleosin PF05042.13 EFA74842.1 - 0.041 13.8 0.2 0.58 10.1 0.0 2.5 2 1 1 3 3 3 0 Caleosin related protein GST_C_3 PF14497.6 EFA74843.1 - 7e-17 61.4 0.1 1.1e-16 60.8 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA74843.1 - 1.4e-08 34.9 0.0 4.1e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA74843.1 - 0.0013 18.9 0.1 0.0041 17.3 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA74843.1 - 0.0041 17.5 0.0 0.012 16.0 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA74843.1 - 0.11 12.6 0.1 1.1 9.3 0.0 2.3 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA74843.1 - 0.11 12.3 0.1 0.27 11.1 0.1 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Mucin PF01456.17 EFA74844.1 - 0.12 12.4 23.7 0.16 11.9 23.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FNIP PF05725.12 EFA74845.1 - 4.6e-18 65.1 46.1 1.4e-08 34.8 0.1 10.1 8 4 1 10 10 10 6 FNIP Repeat F-box_5 PF18511.1 EFA74845.1 - 5.3e-06 25.9 0.2 1.2e-05 24.8 0.2 1.5 1 0 0 1 1 1 1 F-box PBP_sp32 PF07222.12 EFA74845.1 - 0.012 15.1 0.1 0.02 14.4 0.1 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TIG PF01833.24 EFA74846.1 - 4.7e-12 45.8 56.4 0.00011 22.2 2.8 8.4 6 1 2 8 8 8 4 IPT/TIG domain EGF_2 PF07974.13 EFA74846.1 - 0.00064 20.0 13.2 0.00064 20.0 13.2 2.1 2 0 0 2 2 2 1 EGF-like domain RP854 PF17460.2 EFA74846.1 - 0.1 12.4 2.7 0.2 11.4 0.5 2.3 2 0 0 2 2 2 0 Uncharacterized protein RP854 LapA_dom PF06305.11 EFA74846.1 - 0.15 11.9 0.2 0.33 10.8 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain hEGF PF12661.7 EFA74846.1 - 2.7 8.8 8.6 9.6 7.0 8.6 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 EFA74846.1 - 4.5 7.5 12.7 0.59 10.3 8.4 1.7 2 0 0 2 2 2 0 Laminin EGF domain DNA_ligase_A_M PF01068.21 EFA74847.1 - 8.2e-65 218.3 0.0 2.5e-64 216.7 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFA74847.1 - 4.7e-33 114.9 0.3 1.3e-30 107.0 0.3 2.8 1 1 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFA74847.1 - 1.8e-27 95.8 0.0 1e-26 93.4 0.0 2.4 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.6 EFA74847.1 - 0.0037 17.2 0.4 0.46 10.6 0.0 3.0 2 0 0 2 2 2 1 DNA ligase OB-like domain DUF924 PF06041.11 EFA74850.1 - 2.5e-50 171.1 0.3 6.1e-50 169.9 0.3 1.7 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) FSH1 PF03959.13 EFA74850.1 - 1.8e-44 151.9 0.1 4.5e-44 150.6 0.1 1.6 1 0 0 1 1 1 1 Serine hydrolase (FSH1) LRR_6 PF13516.6 EFA74850.1 - 3.9e-12 45.2 18.7 0.013 15.5 0.1 9.0 9 0 0 9 9 9 4 Leucine Rich repeat Abhydrolase_2 PF02230.16 EFA74850.1 - 0.00043 20.2 0.1 0.0011 18.8 0.1 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 EFA74850.1 - 0.00075 19.1 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Fis1_TPR_N PF14852.6 EFA74850.1 - 0.048 13.3 0.1 1.1 9.0 0.0 2.9 3 0 0 3 3 3 0 Fis1 N-terminal tetratricopeptide repeat EamA PF00892.20 EFA74851.1 - 4.6e-13 49.5 36.4 7.2e-07 29.5 6.5 3.0 3 0 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EFA74851.1 - 8.2e-05 22.2 20.2 0.00015 21.4 15.1 2.7 2 1 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 EFA74851.1 - 0.031 13.5 14.7 0.04 13.1 12.0 2.5 2 1 0 2 2 2 0 Purine nucleobase transmembrane transport DUF2208 PF09973.9 EFA74851.1 - 2.6 7.6 17.4 1.3 8.6 0.8 3.8 4 0 0 4 4 4 0 Predicted membrane protein (DUF2208) Mito_carr PF00153.27 EFA74852.1 - 1.6e-60 201.1 5.7 1.4e-19 69.8 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Antimicrobial_6 PF08036.11 EFA74852.1 - 0.16 12.0 0.1 2.8 8.1 0.0 2.3 2 0 0 2 2 2 0 Diapausin family of antimicrobial peptide Tim17 PF02466.19 EFA74852.1 - 0.23 11.8 3.6 0.35 11.3 1.3 2.3 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family SHMT PF00464.19 EFA74853.1 - 6.8e-184 611.1 0.0 8.3e-184 610.8 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 EFA74853.1 - 0.0002 20.7 0.0 0.00047 19.5 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EFA74853.1 - 0.0014 17.6 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFA74853.1 - 0.15 11.2 0.0 0.39 9.8 0.0 1.9 1 1 0 1 1 1 0 Aminotransferase class I and II Cut8 PF08559.10 EFA74854.1 - 1.7e-28 99.9 41.9 2.7e-25 89.4 41.9 3.3 1 1 0 1 1 1 1 Cut8, nuclear proteasome tether protein DSHCT PF08148.12 EFA74854.1 - 0.4 10.3 0.0 0.4 10.3 0.0 2.6 2 1 0 2 2 2 0 DSHCT (NUC185) domain SRI PF08236.11 EFA74855.1 - 0.026 14.7 0.1 0.044 14.0 0.1 1.3 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain ACOX PF01756.19 EFA74856.1 - 1.1e-18 67.5 0.0 2.3e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFA74856.1 - 1.4e-13 50.9 0.0 2.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EFA74856.1 - 4.4e-10 40.2 0.3 9.3e-10 39.1 0.3 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EFA74856.1 - 3.9e-09 36.9 0.0 1.2e-08 35.3 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFA74856.1 - 0.00021 21.9 0.0 0.00056 20.5 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain adh_short PF00106.25 EFA74857.1 - 3.3e-44 150.7 0.0 5.6e-44 149.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA74857.1 - 5.4e-27 94.9 0.0 7.5e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA74857.1 - 9.6e-10 38.7 0.0 2.6e-09 37.3 0.0 1.6 2 1 0 2 2 2 1 KR domain DUF1776 PF08643.10 EFA74857.1 - 9.4e-05 21.9 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFA74857.1 - 0.00011 21.7 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EFA74857.1 - 0.0029 17.2 0.0 0.0053 16.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFA74857.1 - 0.0041 16.6 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA74857.1 - 0.0046 16.9 0.0 0.0077 16.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EFA74857.1 - 0.0062 15.7 0.3 0.0098 15.1 0.3 1.5 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EFA74857.1 - 0.058 12.5 0.0 0.09 11.9 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain EGF_2 PF07974.13 EFA74859.1 - 0.00027 21.2 11.0 0.00027 21.2 11.0 1.7 2 0 0 2 2 2 1 EGF-like domain EGF_Tenascin PF18720.1 EFA74859.1 - 0.037 14.1 5.0 0.085 12.9 5.0 1.7 1 0 0 1 1 1 0 Tenascin EGF domain DUF1573 PF07610.11 EFA74859.1 - 0.08 13.0 0.2 0.37 10.9 0.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) EGF_2 PF07974.13 EFA74860.1 - 0.00045 20.5 14.3 0.00045 20.5 14.3 2.0 2 0 0 2 2 2 1 EGF-like domain CD47 PF04549.14 EFA74860.1 - 0.041 14.1 0.9 0.094 12.9 0.9 1.6 1 0 0 1 1 1 0 CD47 transmembrane region Big_3_2 PF12245.8 EFA74860.1 - 1.1 9.6 8.0 0.77 10.0 0.2 3.6 4 1 0 4 4 4 0 Bacterial Ig-like domain Toxin_11 PF07473.11 EFA74860.1 - 3.9 7.6 8.5 9.8 6.4 8.5 1.7 1 0 0 1 1 1 0 Spasmodic peptide gm9a; conotoxin from Conus species EGF_Tenascin PF18720.1 EFA74860.1 - 4 7.6 10.9 9.7 6.4 10.9 1.7 1 0 0 1 1 1 0 Tenascin EGF domain PH PF00169.29 EFA74861.1 - 7.1e-20 71.5 0.8 7.1e-20 71.5 0.8 2.0 2 1 0 2 2 2 1 PH domain PH_3 PF14593.6 EFA74861.1 - 1.4e-05 25.1 3.2 3.6e-05 23.8 0.3 2.2 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA74861.1 - 0.00012 22.3 0.1 0.00029 21.1 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFA74861.1 - 0.00017 22.0 9.4 0.00034 21.0 2.6 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 EFA74861.1 - 0.0031 17.8 0.7 0.034 14.5 0.7 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 EFA74861.1 - 0.0048 17.2 0.2 0.0048 17.2 0.2 2.0 2 0 0 2 2 2 1 Plant pleckstrin homology-like region Focal_AT PF03623.13 EFA74861.1 - 0.013 15.5 1.1 0.023 14.7 1.1 1.3 1 0 0 1 1 1 0 Focal adhesion targeting region Maf1 PF09174.10 EFA74861.1 - 0.021 15.0 3.3 0.027 14.6 3.3 1.3 1 0 0 1 1 1 0 Maf1 regulator BCL_N PF04714.13 EFA74861.1 - 0.072 13.2 0.1 0.22 11.6 0.1 1.9 1 0 0 1 1 1 0 BCL7, N-terminal conserver region Mst1_SARAH PF11629.8 EFA74861.1 - 1.2 9.2 5.7 0.93 9.6 0.2 2.4 1 1 1 2 2 2 0 C terminal SARAH domain of Mst1 DUF3807 PF12720.7 EFA74862.1 - 0.078 13.3 47.4 0.25 11.6 21.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) RR_TM4-6 PF06459.12 EFA74862.1 - 0.17 11.7 49.3 0.11 12.2 22.4 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CCSAP PF15748.5 EFA74862.1 - 0.71 10.0 41.2 1.9 8.6 11.5 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SOBP PF15279.6 EFA74862.1 - 2.9 8.4 21.5 4.2 7.9 2.5 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein RNA_polI_A34 PF08208.11 EFA74862.1 - 5.6 7.0 90.1 1.7 8.7 31.5 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DAG_kinase_N PF14513.6 EFA74862.1 - 6 7.0 29.0 1.8 8.7 11.2 2.3 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Tim54 PF11711.8 EFA74862.1 - 9.1 5.0 44.0 1.4 7.6 13.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Apis_Csd PF11671.8 EFA74863.1 - 0.81 9.7 10.9 1.9 8.5 10.9 1.6 1 0 0 1 1 1 0 Complementary sex determiner protein TLD PF07534.16 EFA74864.1 - 1.1e-06 28.9 0.2 0.00029 21.1 0.1 2.3 1 1 1 2 2 2 2 TLD DUF4551 PF15087.6 EFA74864.1 - 0.041 12.7 0.2 0.053 12.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Rft-1 PF04506.13 EFA74865.1 - 1.5e-84 284.6 25.1 1.7e-84 284.4 25.1 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_C PF14667.6 EFA74865.1 - 0.008 16.2 20.3 0.008 16.2 20.3 2.3 3 0 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain Imm26 PF15428.6 EFA74865.1 - 0.053 13.7 0.4 0.13 12.6 0.4 1.6 1 0 0 1 1 1 0 Immunity protein 26 UPF0114 PF03350.16 EFA74865.1 - 1.2 9.4 0.0 1.2 9.4 0.0 4.2 2 1 1 3 3 3 0 Uncharacterized protein family, UPF0114 Methyltransf_28 PF02636.17 EFA74866.1 - 3.3e-38 131.8 0.2 9.5e-38 130.3 0.0 1.7 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 EFA74866.1 - 0.00057 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.9 EFA74866.1 - 0.037 13.8 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Pkinase_Tyr PF07714.17 EFA74867.1 - 2.3e-84 282.7 0.1 4.5e-60 203.1 0.0 3.3 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 EFA74867.1 - 1.9e-69 233.9 0.0 1e-47 162.8 0.0 3.3 2 1 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 EFA74867.1 - 2.2e-07 30.5 0.0 0.0008 18.8 0.0 2.6 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EFA74867.1 - 0.00021 20.7 0.0 0.16 11.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFA74867.1 - 0.043 13.4 0.1 0.043 13.4 0.1 2.4 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 zf-C3HC4_2 PF13923.6 EFA74868.1 - 3e-09 36.5 9.9 5.9e-09 35.6 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA74868.1 - 3.8e-09 36.7 10.4 3.8e-09 36.7 10.4 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EFA74868.1 - 7.7e-09 35.3 10.6 1.5e-08 34.4 10.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA74868.1 - 1.7e-07 31.1 3.5 2.3e-07 30.7 2.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFA74868.1 - 7.2e-07 29.4 8.1 1.8e-06 28.1 8.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA74868.1 - 7.6e-07 28.9 7.6 7.6e-07 28.9 7.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA74868.1 - 2.1e-06 27.5 7.8 4.7e-06 26.4 7.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFA74868.1 - 0.00016 21.7 7.4 0.00054 20.1 7.4 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EFA74868.1 - 0.0012 18.7 2.0 0.0025 17.6 2.0 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 EFA74868.1 - 0.0015 18.5 10.2 0.0035 17.3 10.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EFA74868.1 - 0.0067 16.2 9.1 0.027 14.3 9.1 2.1 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain FYDLN_acid PF09538.10 EFA74868.1 - 0.0085 16.8 6.6 0.0085 16.8 6.6 5.4 2 2 2 4 4 1 1 Protein of unknown function (FYDLN_acid) zf-ANAPC11 PF12861.7 EFA74868.1 - 0.023 14.7 2.6 0.055 13.5 2.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 EFA74868.1 - 0.26 11.2 5.1 0.55 10.2 5.1 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 EFA74868.1 - 0.46 10.7 6.5 1.1 9.4 6.5 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-MIZ PF02891.20 EFA74868.1 - 0.48 10.2 8.4 1 9.2 8.4 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_11 PF17123.5 EFA74868.1 - 6.3 6.6 10.6 1.5 8.6 7.0 1.9 2 0 0 2 2 2 0 RING-like zinc finger DUF3439 PF11921.8 EFA74869.1 - 8.8 6.3 22.1 1.8 8.6 2.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Med14 PF08638.11 EFA74870.1 - 8.2e-55 185.2 1.2 2.1e-54 183.8 0.0 2.3 2 0 0 2 2 2 1 Mediator complex subunit MED14 Spt20 PF12090.8 EFA74870.1 - 1.1 8.8 22.2 0.38 10.3 3.4 2.6 2 0 0 2 2 2 0 Spt20 family Histone PF00125.24 EFA74871.1 - 1e-47 161.8 3.6 1.1e-47 161.6 3.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFA74871.1 - 3.3e-05 23.9 0.8 4.7e-05 23.5 0.2 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFA74871.1 - 0.00011 22.6 0.1 0.00017 21.9 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EFA74871.1 - 0.00076 20.1 1.3 0.00098 19.7 1.3 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain HisKA PF00512.25 EFA74871.1 - 0.0034 17.4 0.1 0.0062 16.6 0.1 1.4 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain TFIID-31kDa PF02291.15 EFA74871.1 - 0.015 15.4 0.1 0.026 14.6 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Pkinase PF00069.25 EFA74872.1 - 9.2e-68 228.5 0.1 9.2e-68 228.5 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74872.1 - 1.3e-43 149.2 0.1 2.3e-43 148.4 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA74872.1 - 0.007 15.2 0.0 0.007 15.2 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFA74872.1 - 0.0079 16.1 0.0 0.067 13.1 0.1 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Ribosomal_L35Ae PF01247.18 EFA74873.1 - 3.5e-37 126.4 0.1 3.9e-37 126.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EFA74873.1 - 0.062 13.5 0.0 4.4 7.6 0.0 2.2 2 0 0 2 2 2 0 RimM N-terminal domain RPEL PF02755.15 EFA74874.1 - 1.2e-12 47.1 18.0 8.1e-08 31.7 1.3 6.9 7 0 0 7 7 7 5 RPEL repeat TFIIA PF03153.13 EFA74874.1 - 0.1 12.5 34.0 0.14 12.2 34.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit hGDE_N PF14699.6 EFA74875.1 - 0.13 12.4 0.5 0.25 11.5 0.5 1.5 1 1 0 1 1 1 0 N-terminal domain from the human glycogen debranching enzyme AP-5_subunit_s1 PF15001.6 EFA74876.1 - 2e-20 73.6 0.7 9.1e-17 61.7 0.1 2.4 2 1 0 2 2 2 2 AP-5 complex subunit sigma-1 Clat_adaptor_s PF01217.20 EFA74876.1 - 0.00041 20.3 0.3 0.00069 19.6 0.3 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Sec16_C PF12931.7 EFA74877.1 - 4.4e-12 46.3 0.9 2.1e-10 40.7 0.9 2.4 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 EFA74877.1 - 2.3e-08 34.5 10.4 0.018 15.9 0.4 6.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA74877.1 - 0.00013 22.2 0.2 0.15 12.4 0.0 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain SUIM_assoc PF16619.5 EFA74877.1 - 0.00039 20.4 3.3 0.2 11.7 0.0 3.3 2 1 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 Mit_ribos_Mrp51 PF11709.8 EFA74877.1 - 0.033 13.8 1.5 0.056 13.0 1.5 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit LVIVD PF08309.11 EFA74877.1 - 0.1 11.9 0.2 0.35 10.2 0.2 1.9 1 0 0 1 1 1 0 LVIVD repeat Nup214_FG PF18617.1 EFA74877.1 - 0.1 13.1 0.3 0.26 11.8 0.3 1.6 1 0 0 1 1 1 0 Nucleoporin Nup214 phenylalanine-glycine (FG) domain Sec16 PF12932.7 EFA74877.1 - 0.24 12.0 3.4 1.4 9.6 3.4 2.3 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region AMP-binding PF00501.28 EFA74878.1 - 5.7e-48 163.6 0.0 8.1e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Prp18 PF02840.15 EFA74878.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Prp18 domain RlaP PF10127.9 EFA74879.1 - 1.2e-07 31.6 10.9 0.00016 21.3 3.6 4.0 2 2 1 3 3 3 3 RNA repair pathway DNA polymerase beta family RTT107_BRCT_5 PF16770.5 EFA74881.1 - 2.2e-13 49.9 0.2 2.2e-13 49.9 0.2 4.4 6 0 0 6 6 6 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EFA74881.1 - 1.7e-09 38.0 0.7 0.00017 21.9 0.1 4.1 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain FHA PF00498.26 EFA74881.1 - 3.2e-07 30.6 0.5 1.4e-06 28.5 0.1 2.4 2 0 0 2 2 2 1 FHA domain BRCT PF00533.26 EFA74881.1 - 2.3e-06 27.9 1.0 0.00083 19.7 0.1 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Yop-YscD_cpl PF16697.5 EFA74881.1 - 0.0021 18.3 3.3 0.0031 17.8 0.0 2.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain PTCB-BRCT PF12738.7 EFA74881.1 - 0.023 14.6 0.1 0.052 13.5 0.1 1.6 1 0 0 1 1 1 0 twin BRCT domain BTB PF00651.31 EFA74882.1 - 6.6e-11 42.4 0.0 1.7e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain AMP-binding PF00501.28 EFA74883.1 - 2.6e-49 168.0 0.0 3.7e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ZZ PF00569.17 EFA74883.1 - 0.98 9.3 12.2 2.3 8.1 12.2 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type BDV_M PF16520.5 EFA74884.1 - 0.16 12.4 0.3 36 4.8 0.0 3.0 3 0 0 3 3 3 0 ssRNA-binding matrix protein of Bornaviridae AMP-binding PF00501.28 EFA74885.1 - 7.7e-50 169.7 0.0 1.1e-49 169.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme zf-B_box PF00643.24 EFA74885.1 - 2.4e-06 27.6 6.0 2.4e-06 27.6 6.0 2.7 2 1 0 2 2 2 1 B-box zinc finger DUF3295 PF11702.8 EFA74886.1 - 0.38 10.0 3.3 0.44 9.9 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) zf-B_box PF00643.24 EFA74887.1 - 1.9e-06 27.9 6.0 1.9e-06 27.9 6.0 2.0 2 0 0 2 2 2 1 B-box zinc finger Kelch_6 PF13964.6 EFA74887.1 - 0.00051 20.2 7.5 3.7 8.0 0.6 5.1 4 2 1 5 5 5 2 Kelch motif Kelch_5 PF13854.6 EFA74887.1 - 0.0058 16.6 3.7 0.064 13.3 0.3 3.6 3 0 0 3 3 3 1 Kelch motif Ntox28 PF15605.6 EFA74887.1 - 0.046 14.0 1.9 0.49 10.7 0.1 2.5 2 0 0 2 2 2 0 Bacterial toxin 28 Prefoldin PF02996.17 EFA74887.1 - 0.091 12.7 2.6 5.4 7.0 0.6 2.7 2 1 1 3 3 3 0 Prefoldin subunit Kelch_2 PF07646.15 EFA74887.1 - 0.71 10.0 4.9 12 6.1 0.1 3.2 3 0 0 3 3 3 0 Kelch motif adh_short PF00106.25 EFA74888.1 - 9.1e-45 152.5 1.4 1.2e-44 152.2 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA74888.1 - 3.6e-41 141.3 0.3 4.4e-41 141.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA74888.1 - 6.6e-14 52.2 0.8 1.3e-13 51.3 0.8 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA74888.1 - 7.9e-05 22.2 0.4 0.00016 21.3 0.4 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA74888.1 - 0.0006 18.9 1.0 0.0041 16.2 0.9 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EFA74888.1 - 0.00066 19.9 0.1 0.0012 19.1 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EFA74888.1 - 0.015 15.6 0.1 0.026 14.8 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain ADH_zinc_N PF00107.26 EFA74888.1 - 0.016 15.2 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase eRF1_3 PF03465.15 EFA74888.1 - 0.042 14.3 0.1 0.093 13.2 0.1 1.5 1 0 0 1 1 1 0 eRF1 domain 3 GDP_Man_Dehyd PF16363.5 EFA74888.1 - 0.057 12.8 0.3 0.1 12.0 0.3 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase ANAPC4_WD40 PF12894.7 EFA74889.1 - 9.1e-13 48.3 0.4 0.0029 17.9 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA74889.1 - 3.5e-06 27.7 2.8 0.17 12.8 0.1 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFA74889.1 - 0.0014 17.8 0.5 0.17 10.9 0.1 2.5 1 1 1 2 2 2 2 Coatomer WD associated region NdhO PF11910.8 EFA74889.1 - 0.0064 16.6 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 Cyanobacterial and plant NDH-1 subunit O Mur_ligase_C PF02875.21 EFA74890.1 - 0.072 13.4 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain DUF3246 PF11596.8 EFA74890.1 - 0.25 10.7 4.9 0.34 10.3 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Tn7_Tnp_TnsA_N PF08722.11 EFA74892.1 - 0.0088 16.2 1.8 0.018 15.2 1.7 1.8 1 1 0 1 1 1 1 TnsA endonuclease N terminal p450 PF00067.22 EFA74893.1 - 9.9e-74 248.7 0.6 1.3e-73 248.3 0.6 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF4296 PF14129.6 EFA74893.1 - 0.057 14.0 0.2 0.15 12.7 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) mCpol PF18182.1 EFA74894.1 - 0.97 9.8 5.1 0.43 10.9 0.3 2.9 2 1 1 3 3 3 0 minimal CRISPR polymerase domain DUF4171 PF13775.6 EFA74894.1 - 2.1 8.8 10.2 0.19 12.2 5.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) RhoGAP PF00620.27 EFA74895.1 - 3.8e-49 166.4 0.0 3.8e-49 166.4 0.0 2.2 3 0 0 3 3 3 1 RhoGAP domain PH PF00169.29 EFA74895.1 - 9.3e-13 48.6 0.9 1.7e-12 47.8 0.1 1.9 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.28 EFA74895.1 - 6e-08 32.2 0.1 1.2e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA74895.1 - 1.6e-07 30.9 0.0 3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFA74895.1 - 1.2e-06 28.3 0.2 2.6e-06 27.2 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EFA74895.1 - 0.00013 22.3 0.3 0.00013 22.3 0.3 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain TUG-UBL1 PF11470.8 EFA74895.1 - 0.0036 17.5 0.7 0.02 15.1 0.0 2.6 2 0 0 2 2 2 1 TUG ubiquitin-like domain DUF1708 PF08101.11 EFA74895.1 - 0.018 14.3 2.8 0.02 14.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1708) PH_3 PF14593.6 EFA74895.1 - 0.025 14.7 1.2 0.052 13.7 0.1 2.1 2 0 0 2 2 2 0 PH domain PH_8 PF15409.6 EFA74895.1 - 0.11 12.8 3.4 0.084 13.2 0.5 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DUF4570 PF15134.6 EFA74895.1 - 6.9 6.7 14.6 2.7 8.0 6.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) DUF2730 PF10805.8 EFA74895.1 - 7.2 6.8 8.2 11 6.2 4.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Methyltrans_RNA PF04452.14 EFA74896.1 - 2.7e-38 131.6 0.0 3.3e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Glyco_hydro_48 PF02011.15 EFA74896.1 - 0.11 11.0 0.1 0.14 10.7 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 48 SET PF00856.28 EFA74897.1 - 1.5e-06 28.7 2.7 1.4e-05 25.5 2.7 2.6 1 1 0 1 1 1 1 SET domain E1-E2_ATPase PF00122.20 EFA74898.1 - 4.7e-50 169.6 0.8 4.7e-50 169.6 0.8 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFA74898.1 - 9.5e-38 130.6 0.0 1.7e-37 129.8 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFA74898.1 - 3.2e-21 75.5 7.5 6.6e-10 39.3 0.5 4.4 4 0 0 4 4 4 2 Heavy-metal-associated domain HAD PF12710.7 EFA74898.1 - 0.0015 19.0 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase TctB PF07331.11 EFA74898.1 - 0.0055 17.0 12.3 0.15 12.3 1.6 3.0 3 0 0 3 3 3 2 Tripartite tricarboxylate transporter TctB family Hydrolase_3 PF08282.12 EFA74898.1 - 0.037 13.8 7.3 0.1 12.3 0.1 3.8 3 1 1 4 4 4 0 haloacid dehalogenase-like hydrolase PseudoU_synth_1 PF01416.20 EFA74899.1 - 3.8e-27 94.9 0.0 5.1e-25 88.0 0.0 2.7 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF3347 PF11827.8 EFA74899.1 - 0.0077 16.4 2.3 0.019 15.2 2.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3347) DUF61 PF01886.16 EFA74899.1 - 0.015 15.3 0.2 0.053 13.6 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF61 FCP1_C PF09309.10 EFA74899.1 - 0.44 10.4 4.1 0.77 9.6 4.1 1.3 1 0 0 1 1 1 0 FCP1, C-terminal CorA PF01544.18 EFA74900.1 - 3.1e-05 23.4 7.2 3.1e-05 23.4 7.2 2.7 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein NICE-3 PF07406.11 EFA74900.1 - 0.073 13.0 1.1 0.19 11.7 1.1 1.8 1 0 0 1 1 1 0 NICE-3 protein DUF2207 PF09972.9 EFA74900.1 - 0.094 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2721 PF11026.8 EFA74900.1 - 0.12 12.2 1.8 6.7 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Dor1 PF04124.12 EFA74901.1 - 1.7e-78 263.7 13.0 2.8e-78 263.0 13.0 1.3 1 0 0 1 1 1 1 Dor1-like family Vps54_N PF10475.9 EFA74901.1 - 7.8e-06 25.4 8.6 7.8e-06 25.4 8.6 2.2 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Vps51 PF08700.11 EFA74901.1 - 0.0082 16.2 4.2 0.0082 16.2 4.2 4.1 3 0 0 3 3 3 1 Vps51/Vps67 Occludin_ELL PF07303.13 EFA74901.1 - 2.4 8.9 7.0 20 5.9 0.1 3.4 3 0 0 3 3 3 0 Occludin homology domain Sec34 PF04136.15 EFA74901.1 - 4 7.3 14.8 0.18 11.7 0.7 3.3 3 0 0 3 3 3 0 Sec34-like family Katanin_con80 PF13925.6 EFA74901.1 - 4.7 7.2 8.5 0.25 11.4 0.1 2.9 3 1 1 4 4 4 0 con80 domain of Katanin RNase_PH PF01138.21 EFA74902.1 - 2.6e-33 115.3 0.5 4.8e-33 114.5 0.5 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF2620 PF10941.8 EFA74902.1 - 0.028 14.5 0.4 0.051 13.7 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2620 PvlArgDC PF01862.16 EFA74902.1 - 0.043 13.6 0.1 0.095 12.5 0.1 1.6 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) Rib_5-P_isom_A PF06026.14 EFA74902.1 - 0.07 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Kei1 PF08552.11 EFA74903.1 - 0.011 15.6 1.2 0.011 15.6 1.2 4.4 5 0 0 5 5 5 0 Inositolphosphorylceramide synthase subunit Kei1 Pkinase PF00069.25 EFA74904.1 - 1.1e-19 70.8 0.0 1.5e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA74904.1 - 4.2e-06 26.2 0.0 5.7e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CX9C PF16860.5 EFA74905.1 - 2e-06 27.7 11.0 0.0039 17.2 7.0 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EFA74905.1 - 0.0034 17.5 4.7 0.0034 17.5 4.7 2.2 2 0 0 2 2 2 1 CHCH domain DB PF01682.19 EFA74905.1 - 0.11 12.8 9.0 0.39 11.0 6.0 2.0 1 1 1 2 2 2 0 DB module WD40 PF00400.32 EFA74906.1 - 7.7e-34 115.2 10.7 1.3e-08 35.3 0.0 7.4 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA74906.1 - 4.9e-12 46.0 0.1 0.00021 21.5 0.1 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA74906.1 - 2.8e-06 27.4 2.1 0.025 14.5 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EFA74906.1 - 0.0037 16.6 0.2 0.017 14.5 0.1 2.1 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EFA74906.1 - 0.0068 15.4 0.2 0.46 9.4 0.0 3.6 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein FlaC_arch PF05377.11 EFA74906.1 - 0.0082 16.5 0.1 0.021 15.2 0.1 1.7 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) EMP24_GP25L PF01105.24 EFA74906.1 - 0.016 15.1 0.1 0.042 13.8 0.1 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD WD40_like PF17005.5 EFA74906.1 - 0.017 14.5 0.2 0.69 9.2 0.2 2.6 2 1 1 3 3 3 0 WD40-like domain Cnn_1N PF07989.11 EFA74906.1 - 0.041 14.0 0.2 0.084 13.0 0.2 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 EFA74906.1 - 0.045 13.5 0.9 0.094 12.5 0.9 1.4 1 0 0 1 1 1 0 Septum formation initiator CENP-F_leu_zip PF10473.9 EFA74906.1 - 0.048 13.7 0.5 0.091 12.8 0.5 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EFA74906.1 - 0.06 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Uds1 PF15456.6 EFA74906.1 - 0.07 13.3 0.2 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Up-regulated During Septation Prefoldin_2 PF01920.20 EFA74906.1 - 0.081 12.9 1.5 0.15 12.1 1.5 1.4 1 0 0 1 1 1 0 Prefoldin subunit IL2 PF00715.17 EFA74906.1 - 0.096 12.6 0.8 0.25 11.3 0.3 1.9 2 0 0 2 2 1 0 Interleukin 2 FlxA PF14282.6 EFA74906.1 - 0.1 12.6 0.5 0.52 10.3 0.5 2.2 1 0 0 1 1 1 0 FlxA-like protein bZIP_1 PF00170.21 EFA74906.1 - 0.12 12.4 1.3 0.26 11.4 1.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor TSC22 PF01166.18 EFA74906.1 - 0.17 12.2 0.7 0.35 11.2 0.7 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family Tmemb_cc2 PF10267.9 EFA74906.1 - 0.2 10.8 1.8 0.38 9.9 1.8 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Cep57_CLD_2 PF14197.6 EFA74906.1 - 0.83 9.8 4.5 0.82 9.8 2.4 2.1 3 0 0 3 3 2 0 Centrosome localisation domain of PPC89 Macoilin PF09726.9 EFA74906.1 - 1 7.9 5.3 1.7 7.1 5.3 1.3 1 0 0 1 1 1 0 Macoilin family Arm PF00514.23 EFA74907.1 - 3.3e-08 33.3 3.4 0.092 12.8 0.0 4.4 3 1 1 4 4 4 3 Armadillo/beta-catenin-like repeat SecG PF03840.14 EFA74908.1 - 0.021 14.9 2.5 0.073 13.2 0.2 2.3 2 0 0 2 2 2 0 Preprotein translocase SecG subunit DUF1461 PF07314.11 EFA74908.1 - 0.032 14.1 0.4 0.049 13.5 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) MLANA PF14991.6 EFA74908.1 - 0.049 13.9 0.4 0.049 13.9 0.4 2.1 2 1 1 3 3 3 0 Protein melan-A ODV-E18 PF10717.9 EFA74908.1 - 8.6 6.3 13.8 0.074 12.9 1.0 3.1 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 tRNA-synt_1 PF00133.22 EFA74909.1 - 1e-217 724.2 0.1 1.4e-217 723.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFA74909.1 - 1.7e-25 89.8 0.1 4.1e-25 88.5 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFA74909.1 - 3.2e-13 49.2 1.7 7.1e-05 21.7 0.2 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFA74909.1 - 0.0018 17.7 0.0 0.0062 15.9 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Ras PF00071.22 EFA74910.1 - 8.5e-59 197.8 0.2 9.8e-59 197.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA74910.1 - 6.3e-33 113.5 0.0 9.5e-33 113.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA74910.1 - 9e-13 48.0 0.1 1e-12 47.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA74910.1 - 2.4e-07 30.8 0.0 4.9e-07 29.8 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA74910.1 - 1.8e-05 24.4 0.1 0.0014 18.2 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA74910.1 - 5.1e-05 22.7 0.0 6.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA74910.1 - 0.00029 20.8 0.2 0.018 14.9 0.1 2.3 1 1 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EFA74910.1 - 0.0014 18.4 0.1 0.1 12.4 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EFA74910.1 - 0.0023 17.5 0.1 0.0087 15.7 0.0 1.8 1 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EFA74910.1 - 0.0047 16.5 0.1 0.0078 15.7 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFA74910.1 - 0.006 16.9 0.0 0.015 15.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EFA74910.1 - 0.0077 16.0 0.3 0.32 10.8 0.0 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 EFA74910.1 - 0.017 14.4 0.1 0.094 12.0 0.1 2.0 2 0 0 2 2 2 0 Septin SRPRB PF09439.10 EFA74910.1 - 0.033 13.6 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EFA74910.1 - 0.049 13.0 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 EFA74910.1 - 0.057 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EFA74910.1 - 0.07 13.1 0.0 0.13 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA74910.1 - 0.086 13.2 0.0 0.1 13.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.9 EFA74910.1 - 0.098 11.8 0.2 0.14 11.3 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NTPase_1 PF03266.15 EFA74910.1 - 0.099 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 EFA74910.1 - 0.1 11.8 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 EFA74910.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFA74910.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain G-alpha PF00503.20 EFA74910.1 - 0.24 10.5 1.1 0.72 9.0 0.2 1.9 1 1 1 2 2 2 0 G-protein alpha subunit FERM_N PF09379.10 EFA74911.1 - 0.039 13.9 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 FERM N-terminal domain DEAD PF00270.29 EFA74912.1 - 1.4e-17 64.0 0.0 2e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 EFA74912.1 - 0.076 12.3 0.1 0.36 10.1 0.1 1.8 1 1 1 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit CTU2 PF10288.9 EFA74913.1 - 3.2e-08 33.8 25.6 3.2e-08 33.8 25.6 3.1 3 2 1 4 4 4 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.20 EFA74913.1 - 0.045 13.5 0.3 0.24 11.1 0.3 2.2 1 1 0 1 1 1 0 PP-loop family Coprogen_oxidas PF01218.18 EFA74914.1 - 4e-104 347.5 0.0 4.5e-104 347.3 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Ferrochelatase PF00762.19 EFA74915.1 - 8.8e-108 360.1 0.0 1e-107 359.9 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase ACC_epsilon PF13822.6 EFA74915.1 - 0.076 13.7 0.1 0.17 12.6 0.1 1.6 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit FNIP PF05725.12 EFA74916.1 - 4.1e-19 68.5 38.7 1.9e-06 27.9 0.0 9.2 9 2 1 10 10 10 5 FNIP Repeat F-box_5 PF18511.1 EFA74916.1 - 0.001 18.6 0.1 0.002 17.6 0.1 1.4 1 0 0 1 1 1 1 F-box FNIP PF05725.12 EFA74917.1 - 3.2e-33 113.6 76.0 4.4e-08 33.2 0.1 15.9 11 3 3 16 16 16 9 FNIP Repeat F-box_5 PF18511.1 EFA74917.1 - 3.4e-11 42.5 7.7 2.2e-05 24.0 0.2 2.9 3 0 0 3 3 3 2 F-box F-box-like PF12937.7 EFA74917.1 - 0.0076 16.1 8.0 0.21 11.5 0.3 2.9 3 0 0 3 3 3 2 F-box-like Arrestin_C PF02752.22 EFA74917.1 - 0.025 15.1 0.8 0.61 10.5 0.1 2.6 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain F-box PF00646.33 EFA74917.1 - 0.077 12.9 5.8 3.9 7.5 0.8 3.0 2 0 0 2 2 2 0 F-box domain DUSP PF06337.12 EFA74917.1 - 0.59 10.8 7.0 2.4 8.8 1.6 2.9 2 0 0 2 2 2 0 DUSP domain FNIP PF05725.12 EFA74919.1 - 3.5e-18 65.5 44.0 2e-08 34.3 0.1 10.4 7 2 3 11 11 11 7 FNIP Repeat F-box_5 PF18511.1 EFA74919.1 - 2.9e-07 29.9 0.2 5.3e-07 29.1 0.2 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA74919.1 - 0.0045 16.8 0.3 0.017 15.0 0.3 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA74919.1 - 0.048 13.5 0.4 0.16 11.9 0.4 1.9 1 0 0 1 1 1 0 F-box domain Ank_4 PF13637.6 EFA74920.1 - 4.7e-18 65.3 5.4 0.1 13.2 0.0 8.0 5 2 4 9 9 9 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA74920.1 - 1.6e-14 54.2 5.8 0.0027 18.3 0.2 5.6 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA74920.1 - 1.2e-11 43.7 6.2 18 6.3 0.0 11.7 12 1 1 13 13 13 1 Ankyrin repeat Ank_5 PF13857.6 EFA74920.1 - 1.7e-07 31.4 6.7 3.1 8.2 0.2 7.6 5 3 4 9 9 9 2 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA74920.1 - 0.47 10.1 7.1 1.4 8.6 0.1 4.2 3 2 2 5 5 5 0 Multigene family 530 protein DUF3447 PF11929.8 EFA74920.1 - 1.2 9.1 14.9 0.45 10.5 0.3 5.7 4 2 3 7 7 7 0 Domain of unknown function (DUF3447) FNIP PF05725.12 EFA74921.1 - 8.3e-56 185.9 108.2 7e-08 32.5 0.6 21.2 15 5 7 24 24 24 16 FNIP Repeat F-box_5 PF18511.1 EFA74921.1 - 2.1e-12 46.4 3.0 1.7e-06 27.5 0.3 2.5 2 0 0 2 2 2 2 F-box F-box-like PF12937.7 EFA74921.1 - 0.00015 21.6 1.4 0.047 13.6 0.3 2.7 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EFA74921.1 - 0.0072 16.2 2.8 0.41 10.6 0.5 3.1 2 0 0 2 2 2 1 F-box domain FBD PF08387.10 EFA74921.1 - 7.9 6.5 7.5 10 6.1 0.0 4.8 7 0 0 7 7 7 0 FBD FNIP PF05725.12 EFA74924.1 - 3.8e-07 30.2 12.9 0.00023 21.3 0.1 4.8 4 1 0 5 5 5 2 FNIP Repeat F-box_5 PF18511.1 EFA74924.1 - 1.6e-06 27.5 0.6 3e-06 26.7 0.6 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA74924.1 - 0.04 13.8 0.9 0.096 12.6 0.9 1.6 1 0 0 1 1 1 0 F-box-like DUF3439 PF11921.8 EFA74924.1 - 0.98 9.4 11.5 2.2 8.3 11.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Tir_receptor_C PF07489.11 EFA74924.1 - 1.7 8.5 8.3 2.4 8.1 8.3 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus FNIP PF05725.12 EFA74925.1 - 1.4e-23 82.8 50.5 2.3e-07 30.8 1.0 11.4 8 4 3 11 11 11 6 FNIP Repeat DUF2540 PF10802.8 EFA74925.1 - 0.59 10.3 3.6 1.4 9.0 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2540) AAA PF00004.29 EFA74926.1 - 3.1e-36 124.7 0.0 1.6e-35 122.4 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA74926.1 - 1.2e-11 44.2 0.1 3e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EFA74926.1 - 1e-07 31.8 0.0 5.5e-07 29.5 0.0 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 EFA74926.1 - 2.2e-05 24.5 0.8 0.00036 20.6 0.0 3.2 3 2 0 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFA74926.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFA74926.1 - 0.00041 20.6 2.3 0.037 14.3 0.1 3.5 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EFA74926.1 - 0.0012 19.2 0.5 0.25 11.7 0.2 3.0 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 EFA74926.1 - 0.0056 15.9 0.0 0.013 14.7 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EFA74926.1 - 0.027 13.8 0.1 0.063 12.7 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFA74926.1 - 0.038 14.1 0.1 0.19 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EFA74926.1 - 0.047 14.2 0.1 0.36 11.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFA74926.1 - 0.11 12.1 0.1 0.98 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFA74926.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Ndc1_Nup PF09531.10 EFA74926.1 - 1.4 7.5 9.9 2.3 6.8 9.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Kelch_6 PF13964.6 EFA74927.1 - 3.8e-13 49.2 6.6 1.9e-05 24.8 0.1 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFA74927.1 - 0.00014 21.4 3.7 0.6 9.7 0.2 3.8 3 0 0 3 3 3 2 Kelch motif CCDC117 PF15810.5 EFA74927.1 - 0.19 12.0 5.0 0.11 12.8 2.1 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 117 Phosducin PF02114.16 EFA74928.1 - 3.4e-16 59.0 0.9 4.1e-16 58.7 0.9 1.1 1 0 0 1 1 1 1 Phosducin RtcB PF01139.17 EFA74928.1 - 0.024 13.8 0.1 0.04 13.1 0.1 1.5 2 0 0 2 2 2 0 tRNA-splicing ligase RtcB RNase_HII PF01351.18 EFA74928.1 - 0.49 10.2 3.5 0.63 9.8 2.8 1.6 1 1 0 1 1 1 0 Ribonuclease HII Pro_CA PF00484.19 EFA74928.1 - 0.51 10.6 2.2 20 5.5 0.0 2.3 2 0 0 2 2 2 0 Carbonic anhydrase Spore_III_AF PF09581.10 EFA74928.1 - 2.7 8.0 8.4 1.4 8.9 5.6 1.8 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) APH PF01636.23 EFA74929.1 - 3.4e-11 43.5 0.4 3.1e-10 40.4 0.4 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family cNMP_binding PF00027.29 EFA74930.1 - 1.3e-44 150.1 0.0 2.6e-21 75.5 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain ATP-synt_DE_N PF02823.16 EFA74930.1 - 0.033 14.1 0.5 5.2 7.0 0.1 2.4 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 7TMR-HDED PF07697.11 EFA74930.1 - 0.043 13.9 2.8 0.56 10.3 0.4 2.5 2 1 0 2 2 2 0 7TM-HD extracellular Cupin_2 PF07883.11 EFA74930.1 - 0.26 11.0 0.9 0.98 9.2 0.1 2.1 2 1 0 2 2 2 0 Cupin domain DUSP PF06337.12 EFA74931.1 - 2e-10 41.1 0.6 2e-10 41.1 0.6 2.1 2 0 0 2 2 2 1 DUSP domain Adaptin_N PF01602.20 EFA74932.1 - 3.7e-123 411.8 16.4 4.8e-123 411.5 16.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFA74932.1 - 1e-11 45.2 4.4 1e-09 38.7 0.2 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 AP3D1 PF06375.11 EFA74932.1 - 2.2e-08 34.5 14.6 0.00011 22.4 0.8 3.3 2 1 1 3 3 3 2 AP-3 complex subunit delta-1 RTP1_C1 PF10363.9 EFA74932.1 - 0.0028 17.8 1.4 6.6 7.0 0.1 3.5 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EFA74932.1 - 0.0064 16.6 5.0 2.8 8.4 0.0 4.2 5 0 0 5 5 5 2 HEAT repeat DUF4139 PF13598.6 EFA74932.1 - 0.026 14.3 0.0 0.062 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) Alpha_adaptinC2 PF02883.20 EFA74932.1 - 0.026 14.8 0.1 0.12 12.6 0.1 2.1 1 1 0 1 1 1 0 Adaptin C-terminal domain DUF3157 PF11355.8 EFA74932.1 - 0.051 13.2 0.2 3.4 7.3 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3157) RasGEF_N_2 PF14663.6 EFA74932.1 - 0.068 13.6 0.1 6.4 7.2 0.1 2.9 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain AP4E_app_platf PF14807.6 EFA74932.1 - 0.11 12.8 0.1 0.44 10.9 0.1 2.1 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Tti2 PF10521.9 EFA74932.1 - 0.36 10.3 4.0 0.29 10.6 0.2 2.7 3 0 0 3 3 3 0 Tti2 family Mis12 PF05859.12 EFA74932.1 - 1.1 9.3 6.5 0.52 10.4 0.2 3.1 4 0 0 4 4 4 0 Mis12 protein HMA PF00403.26 EFA74933.1 - 0.00018 21.9 0.1 0.00042 20.7 0.1 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain MerT PF02411.15 EFA74933.1 - 0.00089 19.3 2.2 0.0016 18.5 2.2 1.4 1 0 0 1 1 1 1 MerT mercuric transport protein DUF4634 PF15465.6 EFA74933.1 - 4.9 7.5 6.4 1.4 9.2 2.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4634) zf-CCHC PF00098.23 EFA74934.1 - 5.2e-56 184.4 67.6 1.7e-08 34.1 2.3 7.3 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EFA74934.1 - 8e-17 60.9 45.3 0.0085 16.0 1.3 7.2 3 3 4 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 EFA74934.1 - 4.2e-07 29.6 47.4 0.13 12.0 0.8 7.2 6 1 1 7 7 7 7 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 EFA74934.1 - 1.3e-05 24.8 47.9 0.34 10.7 1.2 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_6 PF15288.6 EFA74934.1 - 0.074 12.9 0.5 0.074 12.9 0.5 7.2 6 1 1 7 7 7 0 Zinc knuckle zf-CCHC_2 PF13696.6 EFA74934.1 - 1 9.2 61.5 0.31 10.9 2.8 7.4 7 0 0 7 7 7 0 Zinc knuckle Presenilin PF01080.17 EFA74934.1 - 8.1 5.1 6.9 8.8 5.0 6.9 1.1 1 0 0 1 1 1 0 Presenilin Ank_2 PF12796.7 EFA74935.1 - 8e-09 36.0 4.5 0.00013 22.4 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA74935.1 - 1.9e-07 31.2 4.1 0.085 13.2 0.1 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA74935.1 - 1.6e-06 28.5 4.6 0.075 13.6 0.1 4.7 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Laminin_EGF PF00053.24 EFA74935.1 - 4.3e-05 23.6 20.6 0.021 15.0 3.3 2.8 2 0 0 2 2 2 2 Laminin EGF domain Ank_3 PF13606.6 EFA74935.1 - 0.012 16.1 2.3 59 4.7 0.0 5.0 6 0 0 6 6 6 0 Ankyrin repeat DUF249 PF03158.13 EFA74935.1 - 0.031 14.0 2.7 0.87 9.3 0.1 3.3 2 2 2 4 4 4 0 Multigene family 530 protein DUF5049 PF16468.5 EFA74935.1 - 0.097 12.6 0.1 0.69 9.8 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5049) Ank_2 PF12796.7 EFA74936.1 - 4.1e-41 139.5 35.9 3.8e-08 33.8 0.4 7.6 1 1 11 12 12 12 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA74936.1 - 1.7e-27 95.4 18.7 8.6e-05 23.0 0.1 10.3 9 1 0 9 9 9 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA74936.1 - 1.1e-20 73.4 14.8 0.04 14.3 0.1 13.5 5 3 10 15 15 15 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74936.1 - 4.3e-20 69.7 13.1 6 7.8 0.0 14.2 13 1 1 14 14 14 5 Ankyrin repeat DUF3447 PF11929.8 EFA74936.1 - 0.0031 17.5 31.9 0.85 9.6 0.0 7.7 4 2 4 8 8 8 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA74936.1 - 0.22 12.1 15.0 8.6 7.0 0.2 8.0 7 2 3 10 10 10 0 Ankyrin repeat Cofilin_ADF PF00241.20 EFA74937.1 - 2.9e-07 30.3 0.0 3.5e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ank_2 PF12796.7 EFA74938.1 - 9.8e-27 93.4 1.7 2.9e-06 27.8 0.1 6.8 3 3 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA74938.1 - 1.8e-22 79.4 5.8 0.015 15.9 0.2 11.2 8 4 3 11 11 11 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74938.1 - 2.6e-17 61.1 8.3 0.29 11.8 0.0 13.5 15 1 1 16 16 16 3 Ankyrin repeat Ank_5 PF13857.6 EFA74938.1 - 1e-15 57.6 5.7 0.085 13.2 0.0 10.5 6 2 7 13 13 13 5 Ankyrin repeats (many copies) Ank PF00023.30 EFA74938.1 - 0.03 14.8 1.3 36 5.0 0.1 5.0 5 1 1 6 6 6 0 Ankyrin repeat DUF5049 PF16468.5 EFA74938.1 - 0.091 12.7 0.0 7.2 6.6 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) Ank_4 PF13637.6 EFA74939.1 - 4.2e-23 81.4 3.0 0.0023 18.5 0.0 8.8 6 3 3 9 9 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA74939.1 - 5.9e-22 78.1 8.0 4.2e-06 27.3 0.0 5.7 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA74939.1 - 5.6e-15 55.2 4.4 0.017 15.4 0.0 8.4 7 2 2 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74939.1 - 1.2e-14 53.0 3.4 0.037 14.6 0.0 9.2 9 1 1 10 10 10 3 Ankyrin repeat Ank PF00023.30 EFA74939.1 - 3.4e-05 24.1 1.3 6.3 7.4 0.0 6.1 9 0 0 9 9 9 1 Ankyrin repeat DUF3447 PF11929.8 EFA74939.1 - 0.00029 20.7 24.1 0.18 11.8 1.6 6.2 1 1 6 7 7 7 4 Domain of unknown function (DUF3447) Ank_4 PF13637.6 EFA74940.1 - 0.05 14.2 0.0 31 5.3 0.0 3.6 2 1 2 4 4 4 0 Ankyrin repeats (many copies) Myosin_head PF00063.21 EFA74941.1 - 1.6e-221 737.1 0.1 1.6e-221 737.1 0.1 3.7 2 1 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 EFA74941.1 - 4.8e-12 46.1 0.0 4.8e-12 46.1 0.0 5.2 4 3 3 7 7 7 1 DIL domain IQ PF00612.27 EFA74941.1 - 1.4e-10 40.0 30.0 0.00069 19.2 1.8 6.6 6 0 0 6 6 6 4 IQ calmodulin-binding motif UPF0242 PF06785.11 EFA74941.1 - 0.00042 20.5 26.9 0.00042 20.5 26.9 9.2 1 1 7 8 8 8 2 Uncharacterised protein family (UPF0242) N-terminus DUF4164 PF13747.6 EFA74941.1 - 0.00088 19.5 6.7 0.00088 19.5 6.7 10.6 6 3 3 10 10 10 3 Domain of unknown function (DUF4164) ERM PF00769.19 EFA74941.1 - 0.00099 19.0 31.2 0.00099 19.0 31.2 6.2 2 1 4 6 6 6 2 Ezrin/radixin/moesin family Spc7 PF08317.11 EFA74941.1 - 0.0011 17.9 28.2 0.0011 17.9 28.2 7.5 1 1 6 7 7 7 3 Spc7 kinetochore protein AAA_16 PF13191.6 EFA74941.1 - 0.26 11.7 0.0 0.26 11.7 0.0 3.8 3 2 0 3 3 3 0 AAA ATPase domain A1_Propeptide PF07966.12 EFA74941.1 - 1.6 8.7 4.9 0.77 9.7 0.6 2.9 2 0 0 2 2 2 0 A1 Propeptide AMP-binding PF00501.28 EFA74942.1 - 1.4e-52 178.7 0.0 2.1e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme TIG PF01833.24 EFA74942.1 - 7.7e-05 22.7 0.4 7.7e-05 22.7 0.4 4.3 4 1 1 5 5 5 2 IPT/TIG domain EB PF01683.18 EFA74942.1 - 0.0054 17.0 6.1 0.018 15.3 6.1 1.9 1 0 0 1 1 1 1 EB module DUF4488 PF14869.6 EFA74942.1 - 0.051 13.5 0.1 0.17 11.8 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) EGF_2 PF07974.13 EFA74942.1 - 0.19 12.1 20.2 0.49 10.8 20.2 1.7 1 0 0 1 1 1 0 EGF-like domain TIG PF01833.24 EFA74943.1 - 4.7e-06 26.6 1.5 3.9e-05 23.6 0.2 3.0 2 2 0 2 2 2 1 IPT/TIG domain EB PF01683.18 EFA74943.1 - 0.00044 20.5 5.9 0.00099 19.4 5.9 1.6 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 EFA74943.1 - 0.0018 18.6 19.2 0.004 17.5 19.2 1.6 1 0 0 1 1 1 1 EGF-like domain Insulin_TMD PF17870.1 EFA74943.1 - 0.009 16.1 1.8 0.009 16.1 1.8 2.0 2 0 0 2 2 2 1 Insulin receptor trans-membrane segment SieB PF14163.6 EFA74943.1 - 0.034 13.6 1.0 0.079 12.5 1.0 1.6 1 0 0 1 1 1 0 Super-infection exclusion protein B ZYG-11_interact PF05884.12 EFA74943.1 - 0.052 12.9 0.5 0.082 12.3 0.0 1.5 2 0 0 2 2 2 0 Interactor of ZYG-11 LapA_dom PF06305.11 EFA74943.1 - 0.055 13.3 0.2 0.17 11.7 0.2 1.9 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4231 PF14015.6 EFA74943.1 - 0.072 13.6 0.0 0.2 12.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) hEGF PF12661.7 EFA74943.1 - 0.96 10.2 13.1 0.21 12.3 9.4 1.9 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFA74943.1 - 1.8 8.9 12.1 3.9 7.9 12.1 1.6 1 0 0 1 1 1 0 EGF-like domain DDE_1 PF03184.19 EFA74944.1 - 1.7e-11 44.1 0.9 1.7e-11 44.1 0.9 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_psq PF05225.16 EFA74944.1 - 0.0014 18.3 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_3 PF01381.22 EFA74944.1 - 0.0014 18.6 0.1 0.21 11.7 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix HTH_24 PF13412.6 EFA74944.1 - 0.0081 15.7 0.0 0.6 9.7 0.0 3.1 2 1 1 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_19 PF12844.7 EFA74944.1 - 0.012 15.7 3.1 0.067 13.2 0.4 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_37 PF13744.6 EFA74944.1 - 0.017 15.1 0.1 0.039 13.9 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 EFA74944.1 - 0.051 13.1 0.4 1.9 8.0 0.1 2.4 1 1 1 2 2 2 0 Sigma-70, region 4 HTH_26 PF13443.6 EFA74944.1 - 0.083 13.3 0.1 0.48 10.9 0.0 2.1 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain CENP-B_N PF04218.13 EFA74944.1 - 0.77 9.4 3.3 18 5.1 0.2 2.8 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain TIG PF01833.24 EFA74945.1 - 4.5e-05 23.4 15.5 6e-05 23.0 0.6 4.4 3 2 1 4 4 4 2 IPT/TIG domain EB PF01683.18 EFA74945.1 - 0.0025 18.1 5.8 0.0065 16.7 5.8 1.7 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 EFA74945.1 - 0.097 13.1 20.2 0.22 12.0 20.2 1.6 1 0 0 1 1 1 0 EGF-like domain Insulin_TMD PF17870.1 EFA74945.1 - 0.11 12.6 0.7 0.28 11.3 0.7 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment hEGF PF12661.7 EFA74945.1 - 0.14 12.8 9.4 0.41 11.3 9.4 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF Ank_2 PF12796.7 EFA74946.1 - 6.1e-25 87.6 0.7 6e-07 30.0 0.0 4.8 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA74946.1 - 1.4e-24 86.1 1.5 1.6e-05 25.3 0.0 6.8 4 2 1 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA74946.1 - 2.3e-23 82.0 4.6 0.0028 17.9 0.0 9.2 6 3 3 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA74946.1 - 5.8e-20 69.3 0.1 0.051 14.1 0.1 9.8 9 1 1 10 10 10 4 Ankyrin repeat DUF3447 PF11929.8 EFA74946.1 - 6.9e-08 32.3 0.2 0.077 13.0 0.0 4.8 3 3 1 4 4 4 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA74946.1 - 0.00026 21.3 0.1 5.4 7.6 0.0 5.2 5 1 1 6 6 6 1 Ankyrin repeat RVT_1 PF00078.27 EFA74946.1 - 0.043 13.3 0.0 0.083 12.4 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SWIRM-assoc_2 PF16496.5 EFA74947.1 - 8.9e-55 186.2 14.9 8.9e-55 186.2 14.9 8.0 3 2 4 7 7 7 2 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 EFA74947.1 - 4.3e-23 81.5 0.4 4.3e-23 81.5 0.4 2.4 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EFA74947.1 - 1e-18 67.0 6.6 1.1e-17 63.8 6.6 2.9 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EFA74947.1 - 4.2e-10 39.6 0.0 1.1e-09 38.4 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA74947.1 - 8.9e-06 25.9 0.2 5.4e-05 23.4 0.2 2.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain BRCT_2 PF16589.5 EFA74947.1 - 0.037 14.4 0.0 0.58 10.6 0.0 3.3 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Ank_4 PF13637.6 EFA74948.1 - 1.8e-06 28.4 0.4 0.00045 20.7 0.1 3.5 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA74948.1 - 5.9e-05 23.3 0.4 0.0074 16.6 0.0 3.7 2 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA74948.1 - 0.0036 17.9 0.2 0.055 14.1 0.1 2.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA74948.1 - 0.0071 16.8 0.2 1.4 9.7 0.0 4.1 6 0 0 6 6 6 1 Ankyrin repeat Glyco_trans_4_5 PF16994.5 EFA74948.1 - 0.022 14.4 2.8 0.28 10.8 0.1 2.9 2 1 1 3 3 3 0 Glycosyl-transferase family 4 NOP19 PF10863.8 EFA74948.1 - 0.5 10.2 3.4 0.54 10.1 0.3 2.4 2 2 1 3 3 3 0 Nucleolar protein 19 Ank_4 PF13637.6 EFA74949.1 - 8.7e-14 51.7 1.3 0.00065 20.2 0.1 5.3 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA74949.1 - 2.5e-13 50.0 3.6 0.0029 17.9 0.0 5.8 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA74949.1 - 5.1e-13 49.4 0.8 2.1e-05 25.0 0.0 3.2 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA74949.1 - 8.6e-11 41.1 0.4 0.72 10.6 0.0 5.8 4 3 1 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFA74949.1 - 0.0022 18.4 0.0 24 5.6 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat HTH_20 PF12840.7 EFA74949.1 - 0.15 12.2 0.0 5 7.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain SNF2_N PF00176.23 EFA74951.1 - 1.1e-46 159.3 2.6 4.8e-46 157.1 1.5 2.5 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA74951.1 - 1.5e-15 57.5 9.5 1.6e-15 57.4 0.0 3.6 4 0 0 4 4 4 2 Helicase conserved C-terminal domain ResIII PF04851.15 EFA74951.1 - 2.5e-08 34.1 0.1 2.5e-08 34.1 0.1 6.4 4 1 1 5 5 5 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFA74951.1 - 0.0019 17.2 0.1 0.0019 17.2 0.1 2.5 3 0 0 3 3 3 1 P-loop containing NTP hydrolase pore-1 adh_short PF00106.25 EFA74954.1 - 9.9e-47 158.9 0.0 1.3e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA74954.1 - 3.6e-25 88.9 0.0 5e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA74954.1 - 1.2e-10 41.6 0.0 1.7e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EFA74954.1 - 0.0004 19.8 0.2 0.0027 17.1 0.1 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 EFA74954.1 - 0.0053 16.7 0.0 0.0091 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFA74954.1 - 0.0057 16.2 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family LacI PF00356.21 EFA74954.1 - 0.08 12.8 0.5 0.19 11.6 0.5 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family DFP PF04127.15 EFA74954.1 - 0.084 12.7 0.2 0.18 11.6 0.2 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein RhoGAP PF00620.27 EFA74955.1 - 1.2e-23 83.6 2.7 4.5e-23 81.7 0.0 3.0 4 0 0 4 4 4 1 RhoGAP domain FCH PF00611.23 EFA74955.1 - 1.1e-14 54.4 1.6 1.1e-14 54.4 1.6 3.1 4 0 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain DUF4407 PF14362.6 EFA74955.1 - 0.0095 15.3 0.4 1.3 8.3 3.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) Sec1 PF00995.23 EFA74956.1 - 1.2e-61 209.7 28.6 5.6e-35 121.6 11.0 2.5 2 0 0 2 2 2 2 Sec1 family Secretin_N_2 PF07655.13 EFA74956.1 - 0.42 11.2 13.5 1.6 9.3 7.8 3.2 2 0 0 2 2 2 0 Secretin N-terminal domain Ribosomal_L7Ae PF01248.26 EFA74957.1 - 3.1e-18 65.3 0.3 1e-17 63.7 0.3 1.8 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ER_lumen_recept PF00810.18 EFA74958.1 - 4.6e-41 141.1 4.7 4.6e-41 141.1 4.7 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EFA74958.1 - 0.13 12.0 0.3 0.13 12.0 0.3 3.9 4 0 0 4 4 4 0 PQ loop repeat MFS_4 PF06779.14 EFA74959.1 - 0.0012 18.2 21.1 0.0084 15.4 0.8 2.3 1 1 1 2 2 2 2 Uncharacterised MFS-type transporter YbfB YabA PF06156.13 EFA74960.1 - 0.031 14.9 2.0 0.061 14.0 2.0 1.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF155 PF02582.14 EFA74961.1 - 1.1e-39 136.4 0.1 2.4e-39 135.2 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 SOBP PF15279.6 EFA74961.1 - 1.9 9.0 7.3 2.9 8.4 7.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein NPL PF17800.1 EFA74962.1 - 4.2e-16 59.4 0.1 4.2e-16 59.4 0.1 2.0 2 1 0 2 2 2 1 Nucleoplasmin-like domain DUF4604 PF15377.6 EFA74962.1 - 1.3 9.4 28.5 11 6.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) MCM PF00493.23 EFA74963.1 - 1.6e-102 341.3 0.2 2.5e-102 340.7 0.2 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFA74963.1 - 4.3e-35 120.3 0.2 7.5e-35 119.5 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFA74963.1 - 9.2e-24 83.7 0.2 2.3e-23 82.4 0.2 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFA74963.1 - 2e-16 60.4 0.4 5.1e-16 59.1 0.4 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFA74963.1 - 8.9e-08 31.8 0.0 2.7e-06 26.9 0.0 2.3 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM6_C PF18263.1 EFA74963.1 - 2.6e-06 27.6 1.1 2.6e-06 27.6 1.1 2.5 3 0 0 3 3 3 1 MCM6 C-terminal winged-helix domain AAA_3 PF07726.11 EFA74963.1 - 0.00016 21.6 0.0 0.00044 20.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFA74963.1 - 0.00019 21.5 0.0 0.00039 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFA74963.1 - 0.0054 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain RhoGAP PF00620.27 EFA74963.1 - 0.015 15.1 1.5 0.096 12.5 0.2 2.7 3 0 0 3 3 3 0 RhoGAP domain Tir_receptor_M PF03549.14 EFA74963.1 - 0.037 14.4 0.0 0.24 11.8 0.0 2.3 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) intimin-binding domain Spt20 PF12090.8 EFA74964.1 - 0.027 14.1 70.7 0.047 13.3 26.2 3.4 3 0 0 3 3 3 0 Spt20 family MarC PF01914.17 EFA74964.1 - 6.6 6.1 4.5 0.86 9.0 0.1 1.7 2 0 0 2 2 2 0 MarC family integral membrane protein YchF-GTPase_C PF06071.13 EFA74965.1 - 2.9e-29 101.1 0.4 1.8e-18 66.5 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFA74965.1 - 1.7e-22 79.6 0.0 4.2e-22 78.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA74965.1 - 5.2e-07 29.3 0.0 1.2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 EFA74965.1 - 0.011 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 EFA74965.1 - 0.12 12.3 0.0 0.91 9.4 0.0 2.4 3 0 0 3 3 3 0 RsgA GTPase PPC PF04151.15 EFA74966.1 - 0.0059 17.7 2.2 0.0059 17.7 2.2 1.7 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain DUF2448 PF10476.9 EFA74966.1 - 0.026 14.4 0.0 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) DNA_alkylation PF08713.11 EFA74966.1 - 0.028 14.1 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 DNA alkylation repair enzyme Importin_rep_3 PF18806.1 EFA74967.1 - 3e-08 33.6 0.1 6.9e-07 29.2 0.0 3.0 2 1 0 2 2 2 1 Importin 13 repeat RIX1 PF08167.12 EFA74967.1 - 0.0084 15.9 6.5 1.6 8.4 0.1 3.1 2 1 0 2 2 2 2 rRNA processing/ribosome biogenesis Perilipin PF03036.16 EFA74968.1 - 2.1e-05 23.7 1.5 2.1e-05 23.7 1.5 3.1 1 1 2 3 3 3 1 Perilipin family PRORP PF16953.5 EFA74968.1 - 0.00073 19.1 2.0 0.0013 18.3 2.0 1.3 1 0 0 1 1 1 1 Protein-only RNase P IBP39 PF11422.8 EFA74968.1 - 0.0015 18.3 1.8 0.0027 17.5 1.0 1.8 2 0 0 2 2 2 1 Initiator binding protein 39 kDa BAR PF03114.18 EFA74968.1 - 0.12 12.0 3.9 0.79 9.3 0.9 2.8 3 0 0 3 3 3 0 BAR domain ADP_ribosyl_GH PF03747.14 EFA74969.1 - 1.1e-51 176.3 1.3 1.4e-51 176.0 1.3 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase COX17 PF05051.13 EFA74969.1 - 0.23 11.8 1.6 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) MFS_1 PF07690.16 EFA74971.1 - 9.5e-27 93.8 6.7 9.5e-27 93.8 6.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EFA74971.1 - 2.5e-20 72.4 6.7 7.3e-20 70.8 1.0 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_2 PF13347.6 EFA74971.1 - 0.0011 17.6 7.5 0.0011 17.6 7.5 2.3 2 0 0 2 2 2 1 MFS/sugar transport protein Spt20 PF12090.8 EFA74971.1 - 0.0071 16.0 32.8 0.0071 16.0 32.8 3.3 3 0 0 3 3 3 1 Spt20 family PIG-S PF10510.9 EFA74971.1 - 0.47 9.2 18.6 1 8.1 13.5 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein Cons_hypoth698 PF03601.14 EFA74972.1 - 5.9e-35 120.6 16.8 2.5e-32 112.0 11.2 2.1 2 0 0 2 2 2 2 Conserved hypothetical protein 698 6PF2K PF01591.18 EFA74974.1 - 9.2e-82 273.7 0.0 1.3e-81 273.2 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFA74974.1 - 2e-35 122.2 0.0 3.1e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFA74974.1 - 2.3e-05 24.6 0.0 4.7e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain FNIP PF05725.12 EFA74976.1 - 5.7e-35 119.2 10.9 1.2e-11 44.6 2.1 5.6 5 0 0 5 5 5 5 FNIP Repeat BB_PF PF18063.1 EFA74977.1 - 2.8e-61 206.7 3.6 3.4e-61 206.5 3.6 1.1 1 0 0 1 1 1 1 Beta barrel Pore-forming domain Fucokinase PF07959.12 EFA74979.1 - 7.8e-60 202.9 0.0 2.3e-59 201.4 0.0 1.7 2 0 0 2 2 2 1 L-fucokinase GHMP_kinases_N PF00288.26 EFA74979.1 - 2.1e-07 31.1 0.6 4.9e-07 29.9 0.6 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFA74979.1 - 5.3e-06 26.7 0.0 1.6e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 GHMP kinases C terminal ComJ PF11033.8 EFA74979.1 - 0.015 15.0 0.1 8.2 6.2 0.0 2.5 2 0 0 2 2 2 0 Competence protein J (ComJ) DUF2007 PF09413.10 EFA74979.1 - 0.018 15.2 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein G8 PF10162.9 EFA74980.1 - 2e-24 86.0 0.0 4.5e-24 84.9 0.0 1.6 1 0 0 1 1 1 1 G8 domain 2-oxoacid_dh PF00198.23 EFA74982.1 - 1.2e-80 270.4 0.3 1.7e-80 269.9 0.3 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFA74982.1 - 2.8e-20 71.9 1.8 5.1e-20 71.1 1.8 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFA74982.1 - 0.049 13.5 2.9 6.6 6.6 0.1 3.0 2 1 1 3 3 3 0 Biotin-lipoyl like GCV_H PF01597.19 EFA74982.1 - 0.065 13.1 0.4 0.17 11.8 0.4 1.7 1 0 0 1 1 1 0 Glycine cleavage H-protein eIF3_subunit PF08597.10 EFA74982.1 - 0.22 11.4 3.7 0.35 10.8 3.7 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Gp_dh_C PF02800.20 EFA74983.1 - 1.6e-65 219.5 0.0 2.3e-65 219.0 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EFA74983.1 - 5.7e-38 129.3 0.4 1.7e-37 127.8 0.1 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EFA74983.1 - 0.0019 18.3 0.4 0.011 15.8 0.4 2.3 1 1 1 2 2 2 1 Dihydrodipicolinate reductase, N-terminus DNA_pol_B_palm PF14792.6 EFA74984.1 - 6.8e-31 106.8 0.0 1.6e-30 105.7 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 EFA74984.1 - 1.1e-18 67.3 0.8 4e-16 59.1 0.1 2.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_thumb PF14791.6 EFA74984.1 - 1.5e-16 60.3 0.0 7.5e-16 58.1 0.0 2.3 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EFA74984.1 - 6.5e-15 54.7 1.0 2.5e-14 52.8 0.0 2.5 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda HHH_5 PF14520.6 EFA74984.1 - 8e-06 26.4 4.6 0.00061 20.3 0.2 2.7 1 1 1 2 2 2 2 Helix-hairpin-helix domain Trypsin_2 PF13365.6 EFA74984.1 - 1.3e-05 26.2 0.0 4.9e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain NTP_transf_2 PF01909.23 EFA74984.1 - 7.4e-05 23.0 0.1 0.00022 21.4 0.1 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cdd1 PF11731.8 EFA74984.1 - 0.044 14.0 0.1 0.64 10.3 0.0 2.5 1 1 1 2 2 2 0 Pathogenicity locus HHH_2 PF12826.7 EFA74984.1 - 0.048 13.8 0.3 12 6.0 0.0 3.0 3 0 0 3 3 3 0 Helix-hairpin-helix motif HHH_3 PF12836.7 EFA74984.1 - 0.11 12.7 0.2 3 8.2 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif TMF_TATA_bd PF12325.8 EFA74985.1 - 0.43 10.8 7.3 0.12 12.6 1.5 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding adh_short PF00106.25 EFA74986.1 - 1.5e-08 34.3 1.1 8e-08 32.0 0.9 2.0 1 1 1 2 2 2 1 short chain dehydrogenase MLD PF11647.8 EFA74986.1 - 0.0027 17.9 0.3 0.011 16.0 0.0 2.0 2 0 0 2 2 2 1 Membrane Localization Domain KR PF08659.10 EFA74986.1 - 0.013 15.4 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 KR domain 2-Hacid_dh_C PF02826.19 EFA74986.1 - 0.021 14.2 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 EFA74986.1 - 0.091 12.3 1.0 0.22 11.1 0.7 1.7 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase TM231 PF10149.9 EFA74986.1 - 0.14 11.4 2.6 8.1 5.7 0.8 2.4 2 1 0 2 2 2 0 Transmembrane protein 231 Ac110_PIF PF07280.11 EFA74986.1 - 0.16 11.8 0.9 0.31 10.9 0.9 1.5 1 0 0 1 1 1 0 Per os infectivity factor AC110 Synaptobrevin PF00957.21 EFA74987.1 - 2e-24 85.2 4.0 3.1e-24 84.6 4.0 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFA74987.1 - 1.3e-16 60.4 0.0 2.3e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain zf-Di19 PF05605.12 EFA74988.1 - 0.0052 17.1 0.6 0.0087 16.3 0.6 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Tropomyosin PF00261.20 EFA74988.1 - 0.0053 16.2 1.6 0.0053 16.2 1.6 2.1 2 0 0 2 2 2 1 Tropomyosin Lig_C PF18330.1 EFA74989.1 - 0.13 12.3 0.0 0.13 12.2 0.0 1.0 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region Rhomboid PF01694.22 EFA74990.1 - 9.8e-24 84.1 8.8 1.6e-23 83.3 8.8 1.3 1 0 0 1 1 1 1 Rhomboid family RVP_2 PF08284.11 EFA74990.1 - 0.038 13.8 0.7 0.079 12.7 0.7 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease ParA PF10609.9 EFA74991.1 - 4.4e-88 294.9 0.0 8.1e-88 294.0 0.0 1.4 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFA74991.1 - 1.8e-11 44.2 0.0 1.4e-09 38.1 0.0 2.3 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFA74991.1 - 4.5e-08 33.2 0.0 3.5e-05 23.8 0.2 2.4 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 EFA74991.1 - 3.6e-06 26.4 1.6 2.4e-05 23.7 0.2 2.4 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EFA74991.1 - 0.00066 19.5 0.5 0.81 9.5 0.0 2.5 2 1 0 2 2 2 2 AAA domain MipZ PF09140.11 EFA74991.1 - 0.00071 18.9 0.0 0.015 14.6 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ MeaB PF03308.16 EFA74991.1 - 0.0026 16.8 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 EFA74991.1 - 0.0027 17.5 0.0 0.015 15.1 0.0 2.1 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop RsgA_GTPase PF03193.16 EFA74991.1 - 0.0038 17.1 0.3 0.0038 17.1 0.3 2.2 3 0 0 3 3 3 1 RsgA GTPase Zeta_toxin PF06414.12 EFA74991.1 - 0.012 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Fer4_NifH PF00142.18 EFA74991.1 - 0.022 14.2 0.0 0.09 12.2 0.1 1.9 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family IstB_IS21 PF01695.17 EFA74991.1 - 0.05 13.3 0.0 0.49 10.1 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 EFA74991.1 - 0.056 13.0 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain CBP_BcsQ PF06564.12 EFA74991.1 - 0.063 12.7 0.0 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EFA74991.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.6 EFA74991.1 - 0.09 13.2 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 EFA74991.1 - 0.096 12.8 0.4 0.19 11.8 0.4 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 EFA74991.1 - 0.14 12.2 0.4 25 5.0 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase ABC_tran PF00005.27 EFA74991.1 - 0.19 12.2 0.0 0.19 12.2 0.0 2.2 3 0 0 3 3 3 0 ABC transporter FNIP PF05725.12 EFA74992.1 - 5e-42 141.8 28.0 3.6e-12 46.2 0.3 10.2 5 3 3 10 10 10 8 FNIP Repeat LRR_8 PF13855.6 EFA74992.1 - 0.0066 16.2 7.0 0.49 10.2 0.0 5.0 4 1 1 5 5 5 1 Leucine rich repeat PTH2 PF01981.16 EFA74993.1 - 7.2e-48 161.7 1.7 2.2e-47 160.2 1.3 1.8 2 0 0 2 2 2 1 Peptidyl-tRNA hydrolase PTH2 SDA1 PF05285.12 EFA74994.1 - 0.0072 15.8 17.9 0.0081 15.6 17.9 1.3 1 0 0 1 1 1 1 SDA1 ORC_WH_C PF18137.1 EFA74994.1 - 1.9 8.5 12.9 3.6 7.7 12.9 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal SPP PF06550.11 EFA74995.1 - 0.11 12.0 0.7 0.15 11.5 0.7 1.2 1 0 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease Nop14 PF04147.12 EFA74997.1 - 1.8e-223 744.5 67.8 2.1e-223 744.3 67.8 1.0 1 0 0 1 1 1 1 Nop14-like family Asp PF00026.23 EFA74998.1 - 1.8e-36 126.2 0.0 2.5e-35 122.4 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFA74998.1 - 1.2e-15 58.2 0.9 1.8e-15 57.7 0.9 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EFA74998.1 - 2.4e-14 53.4 0.0 4.8e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EFA74998.1 - 0.16 12.6 0.0 1 9.9 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Resolvase PF00239.21 EFA75001.1 - 0.0012 19.0 7.9 0.083 13.0 0.1 3.4 4 0 0 4 4 4 2 Resolvase, N terminal domain GTP_EFTU PF00009.27 EFA75002.1 - 1.5e-63 213.9 0.1 2.3e-63 213.3 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFA75002.1 - 3.1e-30 104.4 0.0 6.3e-30 103.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFA75002.1 - 1.4e-20 73.1 0.0 7.7e-20 70.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFA75002.1 - 6.1e-15 55.4 0.1 2.5e-14 53.4 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFA75002.1 - 3.5e-14 52.7 0.1 3.8e-13 49.3 0.0 2.3 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EFA75002.1 - 0.004 17.2 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-C3Hc3H PF13891.6 EFA75003.1 - 2.8e-32 110.9 15.5 2.2e-16 60.0 3.0 2.5 2 0 0 2 2 2 2 Potential DNA-binding domain DUF4303 PF14136.6 EFA75003.1 - 0.0036 17.0 0.2 0.011 15.5 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4303) zf-primase PF09329.11 EFA75003.1 - 0.0051 16.6 3.5 0.013 15.3 0.2 2.9 3 0 0 3 3 3 1 Primase zinc finger DUF3439 PF11921.8 EFA75003.1 - 0.51 10.3 15.1 5.2 7.1 13.5 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Sigma70_ner PF04546.13 EFA75003.1 - 1.6 8.6 9.8 20 5.0 8.0 2.7 2 0 0 2 2 2 0 Sigma-70, non-essential region WRC PF08879.10 EFA75003.1 - 2.2 8.1 5.6 4.9 6.9 0.1 3.5 3 0 0 3 3 3 0 WRC Syja_N PF02383.18 EFA75004.1 - 1.4e-82 277.6 1.9 1.9e-82 277.2 1.9 1.1 1 0 0 1 1 1 1 SacI homology domain F-actin_cap_A PF01267.17 EFA75005.1 - 3.1e-87 292.4 0.4 9.4e-87 290.8 0.1 2.1 2 0 0 2 2 2 1 F-actin capping protein alpha subunit Myotub-related PF06602.14 EFA75005.1 - 5.8e-62 209.7 0.7 2e-61 207.9 0.7 2.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 EFA75005.1 - 1.5e-32 112.9 0.0 1.4e-30 106.4 0.0 2.5 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75005.1 - 1.7e-26 93.2 0.1 3.2e-23 82.4 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain LRR_8 PF13855.6 EFA75005.1 - 2.5e-25 88.0 53.1 3.9e-10 39.3 7.0 7.6 4 3 3 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 EFA75005.1 - 1.9e-17 63.1 73.7 1.1e-05 25.7 3.6 10.0 8 1 1 9 9 9 7 Leucine Rich repeats (2 copies) COR PF16095.5 EFA75005.1 - 1.1e-09 38.4 0.0 2.8e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_9 PF14580.6 EFA75005.1 - 8.3e-07 28.7 6.1 8.3e-07 28.7 6.1 4.2 2 1 1 4 4 4 1 Leucine-rich repeat Roc PF08477.13 EFA75005.1 - 1.1e-06 28.9 0.1 4.6e-06 26.8 0.0 2.3 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_6 PF13516.6 EFA75005.1 - 0.0076 16.2 27.3 4.9 7.5 0.3 9.8 10 0 0 10 10 10 2 Leucine Rich repeat Clat_adaptor_s PF01217.20 EFA75007.1 - 6.5e-41 139.6 1.3 7.2e-41 139.4 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MAF_flag10 PF01973.18 EFA75007.1 - 0.078 12.7 0.1 0.087 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF115 DDHD PF02862.17 EFA75008.1 - 5.8e-35 121.5 0.4 5.8e-35 121.5 0.4 3.4 2 2 1 3 3 3 1 DDHD domain CLZ PF16526.5 EFA75008.1 - 0.19 12.1 1.0 8.9 6.8 0.0 3.0 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ANAPC_CDC26 PF10471.9 EFA75009.1 - 8.7e-15 55.3 5.3 9.4e-15 55.2 5.3 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 adh_short_C2 PF13561.6 EFA75010.1 - 1.5e-07 31.3 0.0 1.7e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFA75010.1 - 2.6e-07 30.3 0.0 3.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Peptidase_S39 PF02122.15 EFA75010.1 - 0.18 11.3 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Peptidase S39 Isochorismatase PF00857.20 EFA75011.1 - 6.1e-32 111.2 0.0 1.1e-31 110.3 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family Minor_capsid_2 PF11114.8 EFA75011.1 - 0.098 12.7 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Minor capsid protein Ank_4 PF13637.6 EFA75012.1 - 5.8e-17 61.8 0.1 5.5e-09 36.4 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75012.1 - 1.5e-12 47.9 0.2 3.3e-12 46.8 0.2 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFA75012.1 - 8.9e-10 38.6 0.4 0.00084 19.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFA75012.1 - 5.6e-08 32.9 0.1 0.001 19.3 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75012.1 - 8.5e-08 31.9 0.1 0.069 13.7 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat HAGH_C PF16123.5 EFA75013.1 - 2.2e-18 66.5 0.1 4e-18 65.7 0.1 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EFA75013.1 - 4.6e-14 52.9 1.1 2.8e-13 50.3 1.1 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFA75013.1 - 0.00039 20.0 0.1 0.0012 18.4 0.1 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Spindle_Spc25 PF08234.12 EFA75014.1 - 0.028 14.6 0.8 0.23 11.7 0.0 3.1 3 0 0 3 3 3 0 Chromosome segregation protein Spc25 PBP1_TM PF14812.6 EFA75014.1 - 0.073 13.5 1.9 0.31 11.4 1.9 2.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Macro PF01661.21 EFA75015.1 - 1.5e-33 115.3 0.6 4.4e-33 113.8 0.6 1.9 1 0 0 1 1 1 1 Macro domain DUF2795 PF11387.8 EFA75015.1 - 0.16 12.2 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) LPD11 PF18824.1 EFA75015.1 - 0.37 10.9 2.2 0.71 10.0 0.2 2.6 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 Hydrolase PF00702.26 EFA75016.1 - 3.4e-07 30.8 0.0 4.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFA75016.1 - 0.0006 19.9 0.0 0.00086 19.4 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase PAP_central PF04928.17 EFA75017.1 - 9.8e-105 349.0 0.2 2.8e-104 347.5 0.0 1.8 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EFA75017.1 - 1.5e-32 112.5 1.5 1.1e-31 109.7 0.0 2.8 2 1 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EFA75017.1 - 6.4e-09 36.0 0.1 1.9e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EFA75017.1 - 0.003 17.3 0.2 0.025 14.4 0.2 2.4 1 1 0 1 1 1 1 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 EFA75017.1 - 0.061 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase zf_C2H2_10 PF18414.1 EFA75018.1 - 0.033 13.7 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger Homeobox_KN PF05920.11 EFA75019.1 - 8.4e-17 60.8 1.0 8.4e-17 60.8 1.0 2.1 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFA75019.1 - 3.9e-07 29.8 0.1 8.7e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 Homeodomain TNFR_16_TM PF18422.1 EFA75020.1 - 0.0043 17.0 1.4 0.0099 15.8 1.4 1.5 1 0 0 1 1 1 1 Tumor necrosis factor receptor member 16 trans-membrane domain MtrG PF04210.13 EFA75020.1 - 0.01 15.7 2.3 0.05 13.5 2.8 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Chlam_PMP PF02415.17 EFA75020.1 - 0.03 14.8 0.1 0.03 14.8 0.1 6.9 7 0 0 7 7 7 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Protocadherin PF08374.11 EFA75020.1 - 0.064 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Protocadherin SKG6 PF08693.10 EFA75020.1 - 0.11 12.0 3.0 0.21 11.0 3.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 EFA75020.1 - 0.12 12.2 3.1 0.25 11.1 3.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Chordopox_A13L PF05961.11 EFA75020.1 - 1.3 9.3 5.0 0.5 10.6 1.6 2.1 2 0 0 2 2 2 0 Chordopoxvirus A13L protein MOR2-PAG1_C PF14225.6 EFA75021.1 - 2.7e-16 60.2 0.0 8.7e-16 58.5 0.0 1.9 1 0 0 1 1 1 1 Cell morphogenesis C-terminal MOR2-PAG1_N PF14222.6 EFA75021.1 - 3.3e-09 36.3 2.3 7.4e-05 21.9 0.0 2.7 2 1 1 3 3 3 2 Cell morphogenesis N-terminal RGS PF00615.19 EFA75021.1 - 0.00043 20.5 0.0 0.0047 17.2 0.0 3.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain TFIIA PF03153.13 EFA75021.1 - 2.9 7.8 29.8 0.064 13.2 10.1 3.4 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit MoaE PF02391.17 EFA75022.1 - 8.9e-37 125.8 0.1 1.1e-36 125.5 0.1 1.1 1 0 0 1 1 1 1 MoaE protein LRR_6 PF13516.6 EFA75023.1 - 3.2e-07 29.9 5.7 0.16 12.1 0.0 5.6 6 0 0 6 6 6 3 Leucine Rich repeat SAPS PF04499.15 EFA75023.1 - 0.0025 16.7 1.0 0.0025 16.7 1.0 5.1 3 2 1 4 4 4 1 SIT4 phosphatase-associated protein DUF3417 PF11897.8 EFA75024.1 - 0.007 16.8 0.8 0.67 10.4 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3417) LMBR1 PF04791.16 EFA75024.1 - 0.033 13.1 2.1 0.037 12.9 2.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein SUIM_assoc PF16619.5 EFA75024.1 - 0.067 13.3 7.4 0.58 10.3 7.4 2.3 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2680 PF10925.8 EFA75024.1 - 0.5 10.4 6.4 1.3 9.1 6.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) JmjC PF02373.22 EFA75025.1 - 9.9e-38 129.1 0.0 9.9e-38 129.1 0.0 3.0 3 0 0 3 3 3 1 JmjC domain, hydroxylase JmjN PF02375.17 EFA75025.1 - 3.7e-17 62.0 4.5 8.4e-17 60.8 4.5 1.7 1 0 0 1 1 1 1 jmjN domain ARID PF01388.21 EFA75025.1 - 2.7e-15 56.8 0.0 5.7e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain XAF1_C PF18608.1 EFA75025.1 - 0.17 11.5 0.1 0.39 10.3 0.1 1.5 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain ANAPC10 PF03256.16 EFA75026.1 - 1.1e-63 214.2 0.0 1.4e-63 214.0 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 EFA75026.1 - 0.00021 21.4 0.0 0.00021 21.4 0.0 1.7 2 0 0 2 2 2 1 F5/8 type C domain PITH PF06201.13 EFA75026.1 - 0.00064 20.0 0.9 0.00093 19.4 0.9 1.5 1 1 0 1 1 1 1 PITH domain FoP_duplication PF13865.6 EFA75026.1 - 0.00097 19.6 1.6 0.024 15.2 0.8 2.2 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Med1 PF10744.9 EFA75027.1 - 1.1e-23 84.0 12.4 1.1e-23 84.0 12.4 2.7 3 1 0 3 3 3 1 Mediator of RNA polymerase II transcription subunit 1 MMgT PF10270.9 EFA75027.1 - 0.12 12.7 1.8 1.4 9.3 0.1 3.2 3 0 0 3 3 3 0 Membrane magnesium transporter KLRAQ PF10205.9 EFA75027.1 - 5.2 7.4 14.4 0.15 12.3 3.2 3.1 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein SET PF00856.28 EFA75028.1 - 5.6e-09 36.6 5.9 1.4e-06 28.8 0.1 3.7 2 2 0 3 3 3 1 SET domain Ank_4 PF13637.6 EFA75028.1 - 1.9e-08 34.7 0.0 5.1e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75028.1 - 1.9e-07 30.8 0.1 0.00014 22.0 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 EFA75028.1 - 5.5e-07 30.1 0.0 1.4e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFA75028.1 - 6.6e-05 23.2 0.0 0.0021 18.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EFA75028.1 - 8.5e-05 22.8 0.8 0.00017 21.8 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF4898 PF16239.5 EFA75028.1 - 0.092 12.7 1.2 0.26 11.3 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4898) DUF3484 PF11983.8 EFA75028.1 - 0.31 12.2 0.3 0.31 12.2 0.3 2.5 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch DUF3464 PF11947.8 EFA75028.1 - 0.56 10.0 5.3 0.076 12.8 0.6 1.8 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF2116 PF09889.9 EFA75029.1 - 0.0066 16.4 5.5 1.1 9.3 1.4 2.4 2 0 0 2 2 2 2 Uncharacterized protein containing a Zn-ribbon (DUF2116) YHS PF04945.13 EFA75029.1 - 0.0092 16.1 2.3 0.016 15.3 2.3 1.5 1 0 0 1 1 1 1 YHS domain YARHG PF13308.6 EFA75029.1 - 0.021 14.7 3.7 0.022 14.7 1.4 1.8 1 1 1 2 2 2 0 YARHG domain RPAP2_Rtr1 PF04181.13 EFA75029.1 - 0.1 12.9 10.2 0.82 10.0 0.1 2.6 1 1 0 2 2 2 0 Rtr1/RPAP2 family zf-C3HC4_4 PF15227.6 EFA75029.1 - 0.81 9.9 7.5 0.24 11.6 1.7 2.6 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-FCS PF06467.14 EFA75029.1 - 2.4 8.2 13.0 2 8.4 5.6 3.0 2 1 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Ank_2 PF12796.7 EFA75030.1 - 3.5e-29 101.2 12.9 1.9e-06 28.4 0.6 6.7 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75030.1 - 9.8e-28 96.2 7.9 2.4e-05 24.8 0.5 8.4 5 3 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75030.1 - 2.6e-18 64.2 7.5 2.7 8.8 0.0 13.0 11 2 3 14 14 14 3 Ankyrin repeat Ank_5 PF13857.6 EFA75030.1 - 1.7e-16 60.1 9.7 0.0018 18.6 0.5 8.3 4 3 5 9 9 9 4 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA75030.1 - 0.0085 16.0 2.1 6.8 6.7 0.1 5.7 6 1 1 7 7 7 1 Domain of unknown function (DUF5049) FBD PF08387.10 EFA75030.1 - 0.07 13.0 0.3 32 4.5 0.0 4.3 5 0 0 5 5 5 0 FBD ENTH PF01417.20 EFA75030.1 - 0.3 11.1 3.6 3.8 7.6 1.7 3.7 3 1 1 4 4 4 0 ENTH domain YtzH PF14165.6 EFA75030.1 - 0.44 11.0 4.9 0.28 11.6 1.0 2.7 3 1 0 3 3 3 0 YtzH-like protein Glyco_hydro_25 PF01183.20 EFA75031.1 - 0.00034 20.9 0.9 0.00045 20.4 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 zf-C4pol PF14260.6 EFA75031.1 - 0.14 12.6 0.1 0.27 11.7 0.1 1.4 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta T6SS_HCP PF05638.12 EFA75032.1 - 4.5e-13 49.7 0.5 2.1e-12 47.6 0.0 2.2 2 1 1 3 3 3 1 Type VI secretion system effector, Hcp bZIP_1 PF00170.21 EFA75033.1 - 1.5e-09 37.8 12.5 1.5e-09 37.8 12.5 2.2 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFA75033.1 - 1.5e-07 31.4 12.8 1.5e-07 31.4 12.8 3.1 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFA75033.1 - 0.0017 18.8 6.9 0.0017 18.8 6.9 2.8 3 0 0 3 3 3 1 bZIP Maf transcription factor RRM_1 PF00076.22 EFA75035.1 - 4.1e-12 45.7 0.0 1.1e-10 41.1 0.1 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OCRE PF17780.1 EFA75035.1 - 1.6e-09 37.7 11.0 5.2e-09 36.0 11.0 2.0 1 0 0 1 1 1 1 OCRE domain G-patch PF01585.23 EFA75035.1 - 1.6e-05 24.7 0.1 3.5e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 G-patch domain zf-C2H2_6 PF13912.6 EFA75035.1 - 0.0016 18.4 1.4 0.0056 16.6 0.0 2.5 3 0 0 3 3 3 1 C2H2-type zinc finger G-patch_2 PF12656.7 EFA75035.1 - 0.0023 18.0 2.0 0.0023 18.0 2.0 3.2 3 1 1 4 4 4 1 G-patch domain zf-C2HC_2 PF13913.6 EFA75035.1 - 0.021 14.8 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EFA75035.1 - 0.023 15.5 0.1 0.058 14.2 0.1 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFA75035.1 - 0.11 12.8 0.3 0.34 11.2 0.3 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ank_2 PF12796.7 EFA75036.1 - 0.0023 18.5 0.3 0.063 13.9 0.1 2.7 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75036.1 - 0.014 15.9 0.4 2.2 9.1 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat Ank_5 PF13857.6 EFA75036.1 - 0.02 15.2 0.0 0.092 13.1 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) SVA PF05326.11 EFA75036.1 - 0.034 14.2 0.1 0.066 13.2 0.1 1.5 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) Ank_4 PF13637.6 EFA75036.1 - 0.038 14.6 0.5 4.9 7.9 0.0 3.3 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Alpha_kinase PF02816.18 EFA75037.1 - 2.1e-41 142.1 2.2 2.1e-41 142.1 2.2 2.4 3 0 0 3 3 3 1 Alpha-kinase family PRP1_N PF06424.12 EFA75037.1 - 1.1 9.7 15.0 2.1 8.7 4.5 2.3 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF902 PF06001.13 EFA75038.1 - 0.019 15.5 3.9 0.065 13.7 3.9 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF902) Ank_2 PF12796.7 EFA75039.1 - 1.3e-23 83.4 6.2 1.1e-08 35.5 0.4 5.1 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75039.1 - 2.6e-19 69.3 6.6 0.00014 22.4 0.0 7.9 6 1 2 8 8 8 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75039.1 - 7.8e-16 57.9 4.7 0.012 16.0 0.0 7.1 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75039.1 - 2.5e-14 52.0 6.5 0.28 11.9 0.1 10.3 10 1 1 11 11 11 3 Ankyrin repeat DUF3447 PF11929.8 EFA75039.1 - 4.2e-06 26.6 0.2 1.8 8.6 0.0 4.4 3 1 1 4 4 4 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA75039.1 - 5.9e-05 23.3 3.9 25 5.5 0.1 6.6 4 1 3 7 7 7 1 Ankyrin repeat NAD_binding_4 PF07993.12 EFA75040.1 - 4e-61 206.4 0.0 6.5e-61 205.7 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Acyltransferase PF01553.21 EFA75040.1 - 1.8e-22 79.4 0.0 4.2e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Sterile PF03015.19 EFA75040.1 - 9.5e-20 70.6 0.2 2.4e-19 69.3 0.2 1.7 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFA75040.1 - 1.6e-06 27.7 0.0 7.6e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA75040.1 - 6.8e-05 22.0 0.8 0.001 18.1 1.0 2.5 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFA75040.1 - 0.0051 16.3 0.2 0.053 12.9 0.2 2.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFA75040.1 - 0.012 14.8 0.0 0.026 13.7 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Aldedh PF00171.22 EFA75041.1 - 5.2e-134 447.2 0.3 5.9e-134 447.0 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SCAMP PF04144.13 EFA75042.1 - 7.8e-21 75.1 20.3 1.3e-13 51.6 12.4 2.2 1 1 1 2 2 2 2 SCAMP family CNDH2_C PF16858.5 EFA75043.1 - 0.0027 17.6 3.9 0.0038 17.1 3.9 1.3 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term BUD22 PF09073.10 EFA75043.1 - 0.072 12.4 11.4 0.1 12.0 11.4 1.2 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 EFA75043.1 - 0.84 9.2 21.6 1.3 8.5 21.6 1.2 1 0 0 1 1 1 0 PPP4R2 FAM176 PF14851.6 EFA75043.1 - 1 9.0 7.0 3.1 7.5 7.0 1.8 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EFA75043.1 - 1.5 7.0 10.6 2.8 6.1 10.6 1.4 1 0 0 1 1 1 0 CDC45-like protein FYDLN_acid PF09538.10 EFA75043.1 - 1.6 9.5 13.6 0.26 12.0 9.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) SUIM_assoc PF16619.5 EFA75043.1 - 1.8 8.7 10.5 0.069 13.2 2.6 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RRN3 PF05327.11 EFA75043.1 - 2.6 6.5 11.6 0.084 11.4 5.5 1.6 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EFA75043.1 - 8 4.4 24.5 0.65 8.0 19.3 1.6 2 0 0 2 2 2 0 DNA polymerase phi Ank_2 PF12796.7 EFA75044.1 - 6.6e-08 33.0 2.0 2e-07 31.5 0.2 2.5 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75044.1 - 5.3e-07 29.5 0.7 1 10.2 0.0 5.0 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFA75044.1 - 0.0001 22.8 0.6 0.002 18.7 0.0 3.1 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75044.1 - 0.0011 19.3 0.8 6.2 7.3 0.0 3.9 1 1 3 4 4 4 2 Ankyrin repeats (many copies) DUF5059 PF16502.5 EFA75044.1 - 0.1 11.3 0.0 0.13 10.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5059) FNIP PF05725.12 EFA75045.1 - 7e-11 42.1 1.0 5.1e-07 29.7 0.0 4.7 4 1 0 5 5 5 2 FNIP Repeat RNA_pol_Rpb8 PF03870.15 EFA75045.1 - 0.062 13.5 3.1 0.64 10.2 0.5 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb8 NDUF_B5 PF09781.9 EFA75045.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit F-box_5 PF18511.1 EFA75045.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 F-box Ank_5 PF13857.6 EFA75046.1 - 4.2e-19 68.4 1.1 0.00054 20.2 0.0 9.1 3 2 7 10 10 10 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75046.1 - 3.6e-18 65.9 0.7 0.0004 20.9 0.0 5.2 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75046.1 - 8.5e-18 62.6 0.0 4.1 8.3 0.0 10.2 8 2 2 10 10 10 3 Ankyrin repeat Ank_4 PF13637.6 EFA75046.1 - 3e-13 50.0 3.5 0.13 12.9 0.0 7.6 4 2 3 8 8 8 4 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA75046.1 - 0.00037 20.3 4.8 0.62 9.7 0.2 4.0 4 1 0 4 4 4 2 Multigene family 530 protein Helicase_PWI PF18149.1 EFA75046.1 - 0.0019 18.4 0.4 0.041 14.1 0.4 2.7 1 1 1 2 2 2 1 N-terminal helicase PWI domain DUF3447 PF11929.8 EFA75046.1 - 0.073 13.0 2.4 4.1 7.4 0.0 4.0 3 2 1 4 4 4 0 Domain of unknown function (DUF3447) 3-HAO PF06052.12 EFA75046.1 - 0.21 11.2 0.4 1.8 8.2 0.0 2.5 3 0 0 3 3 3 0 3-hydroxyanthranilic acid dioxygenase Kelch_6 PF13964.6 EFA75047.1 - 4.4e-13 49.0 6.5 2.9e-07 30.5 0.1 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA75047.1 - 0.013 15.1 1.9 0.36 10.4 0.1 2.6 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 EFA75047.1 - 0.063 13.3 0.7 9.5 6.3 0.0 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA75047.1 - 0.065 13.2 1.1 0.54 10.3 0.0 3.1 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 EFA75047.1 - 1.9 8.6 4.3 1.6 8.8 0.2 2.8 3 0 0 3 3 3 0 Kelch motif DUF3439 PF11921.8 EFA75047.1 - 7.3 6.6 20.0 0.52 10.3 3.8 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3439) DUF16 PF01519.16 EFA75049.1 - 0.00061 20.2 0.2 0.00061 20.2 0.2 2.5 1 1 1 2 2 2 1 Protein of unknown function DUF16 PI3K_P85_iSH2 PF16454.5 EFA75049.1 - 0.021 14.5 4.5 0.08 12.5 4.5 1.9 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Mpp10 PF04006.12 EFA75049.1 - 0.043 12.3 5.7 0.061 11.8 5.7 1.2 1 0 0 1 1 1 0 Mpp10 protein CLZ PF16526.5 EFA75049.1 - 0.067 13.5 0.2 0.067 13.5 0.2 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels nos_propeller PF18764.1 EFA75049.1 - 0.11 12.4 0.1 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 Nitrous oxide reductase propeller repeat CENP-H PF05837.12 EFA75049.1 - 0.27 11.7 6.5 1.9 8.9 0.4 3.1 3 0 0 3 3 3 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.12 EFA75049.1 - 0.68 10.0 11.9 0.39 10.8 1.8 3.1 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Phage_GPL PF05926.11 EFA75049.1 - 0.8 9.7 3.3 33 4.5 0.1 3.0 2 1 1 3 3 3 0 Phage head completion protein (GPL) KxDL PF10241.9 EFA75049.1 - 0.91 9.8 0.0 0.91 9.8 0.0 2.6 3 0 0 3 3 2 0 Uncharacterized conserved protein ZnuA PF01297.17 EFA75049.1 - 1.2 8.4 4.4 13 5.1 0.3 2.8 2 1 1 3 3 3 0 Zinc-uptake complex component A periplasmic ATG11 PF10377.9 EFA75049.1 - 1.8 8.6 4.3 18 5.4 0.7 2.7 3 0 0 3 3 3 0 Autophagy-related protein 11 ZapB PF06005.12 EFA75049.1 - 4.7 7.7 12.8 15 6.1 3.5 3.2 3 0 0 3 3 3 0 Cell division protein ZapB Carm_PH PF17888.1 EFA75051.1 - 2.8e-10 40.4 0.5 2.8e-10 40.4 0.5 2.3 2 1 0 2 2 2 1 Carmil pleckstrin homology domain LRR_1 PF00560.33 EFA75051.1 - 0.0052 17.2 1.8 1.7 9.5 0.0 4.3 3 0 0 3 3 3 1 Leucine Rich Repeat NmrA PF05368.13 EFA75051.1 - 0.091 12.3 0.2 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family Phage_holin_3_1 PF05106.12 EFA75051.1 - 0.2 12.1 0.9 1.8 9.1 0.0 2.6 3 0 0 3 3 3 0 Phage holin family (Lysis protein S) RhoGAP PF00620.27 EFA75052.1 - 8e-36 123.2 0.0 1.4e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain MHC2-interact PF09307.10 EFA75054.1 - 0.072 13.1 3.3 0.093 12.7 3.3 1.1 1 0 0 1 1 1 0 CLIP, MHC2 interacting PHD_3 PF13922.6 EFA75054.1 - 0.12 12.7 1.3 0.16 12.4 1.3 1.3 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Uteroglobin PF01099.17 EFA75054.1 - 0.18 12.2 0.7 0.22 11.9 0.7 1.2 1 0 0 1 1 1 0 Uteroglobin family Synaptobrevin PF00957.21 EFA75054.1 - 1.9 8.3 5.4 1 9.2 1.3 2.0 1 1 1 2 2 2 0 Synaptobrevin MMgT PF10270.9 EFA75056.1 - 1.4e-13 51.0 0.2 1.8e-13 50.7 0.2 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter Dynein_light PF01221.18 EFA75057.1 - 8.9e-35 118.9 1.4 1e-34 118.7 1.4 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ras PF00071.22 EFA75058.1 - 8.4e-45 152.3 0.1 1.2e-44 151.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75058.1 - 9.7e-29 100.0 0.1 1.5e-28 99.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75058.1 - 1.6e-09 37.5 0.1 2.2e-09 37.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA75058.1 - 1.5e-06 27.7 0.0 2.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EFA75058.1 - 0.00033 20.4 0.0 0.0031 17.2 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EFA75058.1 - 0.0019 18.3 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EFA75058.1 - 0.0021 17.5 0.1 0.06 12.7 0.1 2.5 2 1 1 3 3 3 1 Bacterial TniB protein AAA_7 PF12775.7 EFA75058.1 - 0.0024 17.4 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region GTP_EFTU PF00009.27 EFA75058.1 - 0.0034 16.9 0.4 0.29 10.7 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFA75058.1 - 0.01 15.3 0.0 0.025 14.0 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DLIC PF05783.11 EFA75058.1 - 0.016 14.1 0.0 2.7 6.7 0.1 2.1 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) ATP_bind_1 PF03029.17 EFA75058.1 - 0.022 14.6 0.0 0.82 9.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EFA75058.1 - 0.041 14.3 0.1 0.066 13.6 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF4998 PF16389.5 EFA75058.1 - 0.046 13.3 0.1 0.076 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function TsaE PF02367.17 EFA75058.1 - 0.059 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EFA75058.1 - 0.079 13.2 0.2 0.26 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFA75058.1 - 0.083 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFA75058.1 - 0.12 12.7 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EFA75058.1 - 0.13 11.8 0.0 6.3 6.4 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNase_PH PF01138.21 EFA75059.1 - 1.7e-23 83.5 0.5 3.5e-23 82.6 0.5 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFA75059.1 - 5.2e-05 23.2 0.3 0.00037 20.5 0.1 2.4 3 0 0 3 3 3 1 3' exoribonuclease family, domain 2 Met_10 PF02475.16 EFA75059.1 - 0.043 13.5 0.0 0.079 12.7 0.0 1.5 1 1 0 1 1 1 0 Met-10+ like-protein CLASP_N PF12348.8 EFA75060.1 - 8.9e-25 87.6 18.2 7.6e-10 38.7 0.5 7.5 6 4 1 8 8 8 3 CLASP N terminal HEAT PF02985.22 EFA75060.1 - 2.6e-15 55.2 7.3 0.15 12.4 0.0 9.9 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 EFA75060.1 - 2.5e-10 40.6 4.0 0.74 10.2 0.0 8.8 6 2 2 9 9 9 1 HEAT repeats HEAT_EZ PF13513.6 EFA75060.1 - 4.9e-07 30.1 5.9 0.45 11.1 0.0 7.4 6 1 0 6 6 6 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EFA75060.1 - 5e-05 23.8 2.1 2.7 8.6 0.0 6.9 6 2 2 8 8 8 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EFA75060.1 - 0.00017 21.7 26.0 0.062 13.3 0.2 8.5 5 3 2 7 7 7 2 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.12 EFA75060.1 - 0.00092 18.9 7.9 0.72 9.5 0.1 6.0 4 3 1 5 5 5 2 NUC173 domain UME PF08064.13 EFA75060.1 - 0.0066 16.3 0.5 2.6 8.0 0.1 4.1 2 0 0 2 2 2 1 UME (NUC010) domain CARD PF00619.21 EFA75060.1 - 0.011 15.7 3.0 1.7 8.7 0.0 4.3 4 0 0 4 4 4 0 Caspase recruitment domain ORC4_C PF14629.6 EFA75060.1 - 0.12 11.7 4.8 0.18 11.1 0.1 3.4 4 0 0 4 4 4 0 Origin recognition complex (ORC) subunit 4 C-terminus DUF3349 PF11829.8 EFA75060.1 - 0.22 12.3 6.6 6 7.7 0.1 4.5 5 0 0 5 5 2 0 Protein of unknown function (DUF3349) Xpo1 PF08389.12 EFA75060.1 - 2.4 8.2 0.0 2.4 8.2 0.0 8.5 8 2 1 9 9 9 0 Exportin 1-like protein ATP-synt_DE_N PF02823.16 EFA75061.1 - 1.6e-16 60.0 0.0 2.2e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain C2 PF00168.30 EFA75062.1 - 3.4e-12 46.5 0.1 2e-10 40.9 0.0 2.4 2 0 0 2 2 2 1 C2 domain WW PF00397.26 EFA75062.1 - 3.7e-09 36.5 0.1 3.7e-09 36.5 0.1 3.1 3 0 0 3 3 3 1 WW domain NT-C2 PF10358.9 EFA75062.1 - 0.00034 20.4 0.0 0.0016 18.2 0.0 1.9 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins FNIP PF05725.12 EFA75063.1 - 1e-84 278.4 34.1 1.2e-14 54.2 0.1 10.0 7 1 5 12 12 12 11 FNIP Repeat AAA_35 PF14516.6 EFA75064.1 - 6.7e-07 28.5 0.1 5.3e-06 25.5 0.1 2.2 1 1 0 1 1 1 1 AAA-like domain AAA PF00004.29 EFA75064.1 - 2.9e-06 27.7 0.0 1.4e-05 25.5 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFA75064.1 - 0.053 13.6 0.0 0.33 11.0 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFA75064.1 - 0.081 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 EFA75065.1 - 0.0012 18.9 35.0 0.0014 18.7 35.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 EFA75065.1 - 0.0033 18.1 20.3 0.0046 17.6 20.3 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RR_TM4-6 PF06459.12 EFA75065.1 - 0.0065 16.3 10.3 0.0079 16.1 10.3 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SpoIIP PF07454.11 EFA75065.1 - 0.011 15.2 10.6 0.019 14.4 10.6 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 EFA75065.1 - 0.015 15.1 9.8 0.016 15.0 7.1 2.0 2 0 0 2 2 2 0 Connexin eIF-3_zeta PF05091.12 EFA75065.1 - 0.017 14.1 18.8 0.02 13.9 18.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Exonuc_VII_L PF02601.15 EFA75065.1 - 0.019 14.6 15.4 0.021 14.4 15.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PPL5 PF18168.1 EFA75065.1 - 0.019 14.3 5.8 0.029 13.7 5.8 1.2 1 0 0 1 1 1 0 Prim-pol family 5 EIF4E-T PF10477.9 EFA75065.1 - 0.028 13.2 17.7 0.031 13.1 17.7 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E AAA_23 PF13476.6 EFA75065.1 - 0.049 14.1 21.6 0.083 13.4 21.6 1.4 1 0 0 1 1 1 0 AAA domain DS PF01916.17 EFA75065.1 - 0.051 12.8 0.0 0.051 12.8 0.0 1.5 2 0 0 2 2 1 0 Deoxyhypusine synthase TERB2 PF15101.6 EFA75065.1 - 0.061 13.4 16.3 0.11 12.5 16.3 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Gti1_Pac2 PF09729.9 EFA75065.1 - 0.064 13.3 8.8 0.089 12.9 8.8 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family CPSF100_C PF13299.6 EFA75065.1 - 0.091 12.9 10.1 0.13 12.5 10.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Nop53 PF07767.11 EFA75065.1 - 0.093 12.1 18.9 0.12 11.8 18.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF5095 PF17016.5 EFA75065.1 - 0.099 12.3 10.9 4.5 6.9 8.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5095) EPL1 PF10513.9 EFA75065.1 - 0.11 12.9 11.7 0.18 12.2 11.7 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like PAT1 PF09770.9 EFA75065.1 - 0.13 10.5 26.0 0.15 10.3 26.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 EFA75065.1 - 0.14 12.2 6.8 0.17 11.9 6.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3533 PF12051.8 EFA75065.1 - 0.18 10.7 9.8 0.21 10.5 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Peptidase_S15 PF02129.18 EFA75065.1 - 0.18 11.3 11.4 0.26 10.8 11.4 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF2072 PF09845.9 EFA75065.1 - 0.21 11.8 6.7 0.39 11.0 6.7 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein Radical_SAM_N PF08497.10 EFA75065.1 - 0.21 10.8 8.1 0.28 10.4 8.1 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal Presenilin PF01080.17 EFA75065.1 - 0.24 10.1 14.8 0.33 9.7 14.8 1.2 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 EFA75065.1 - 0.27 10.1 10.0 0.33 9.8 10.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Phage_GPO PF05929.11 EFA75065.1 - 0.28 10.8 14.9 0.33 10.5 14.9 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ALMT PF11744.8 EFA75065.1 - 0.34 9.7 9.4 0.37 9.6 9.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Rrn6 PF10214.9 EFA75065.1 - 0.45 8.9 20.7 0.52 8.7 20.7 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SPG4 PF17325.2 EFA75065.1 - 0.63 11.1 12.0 1.1 10.3 12.0 1.4 1 0 0 1 1 1 0 Stationary phase protein 4 eIF3_subunit PF08597.10 EFA75065.1 - 0.75 9.7 12.0 1.1 9.1 12.0 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit CLN3 PF02487.17 EFA75065.1 - 0.8 8.7 11.1 1.1 8.2 11.1 1.2 1 0 0 1 1 1 0 CLN3 protein VIT1 PF01988.19 EFA75065.1 - 0.95 9.3 9.4 1.5 8.6 9.4 1.2 1 0 0 1 1 1 0 VIT family CSG2 PF16965.5 EFA75065.1 - 1 8.2 8.6 1.5 7.7 8.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Sec62 PF03839.16 EFA75065.1 - 1.3 8.5 10.9 2.4 7.6 10.9 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Scs3p PF10261.9 EFA75065.1 - 1.4 8.3 5.2 2.2 7.7 5.2 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM MTP18 PF10558.9 EFA75065.1 - 2.1 8.3 8.5 6.5 6.7 6.9 2.1 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF702 PF05142.12 EFA75065.1 - 2.2 8.8 14.2 4.5 7.7 14.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Band_3_cyto PF07565.13 EFA75065.1 - 2.4 7.9 14.7 3.5 7.4 14.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FAM60A PF15396.6 EFA75065.1 - 3.1 7.8 13.7 3.8 7.5 13.0 1.4 1 1 0 1 1 1 0 Protein Family FAM60A Pet20 PF08692.10 EFA75065.1 - 3.1 8.5 6.7 5.5 7.7 6.7 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet20 PepSY_TM PF03929.16 EFA75065.1 - 4.1 7.0 6.1 5.6 6.5 6.1 1.2 1 0 0 1 1 1 0 PepSY-associated TM region DUF4410 PF14366.6 EFA75065.1 - 4.2 7.3 7.4 6.5 6.7 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) PepSY_TM_like_2 PF16357.5 EFA75065.1 - 5.1 7.0 13.0 7.5 6.5 13.0 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like FAM176 PF14851.6 EFA75065.1 - 5.2 6.7 8.9 9.4 5.9 8.9 1.3 1 0 0 1 1 1 0 FAM176 family Nucleoside_tran PF01733.18 EFA75065.1 - 5.2 6.4 7.8 2.2 7.6 5.0 1.8 2 0 0 2 2 2 0 Nucleoside transporter Kei1 PF08552.11 EFA75065.1 - 6.2 6.7 9.2 1.7 8.5 6.3 1.6 2 0 0 2 2 1 0 Inositolphosphorylceramide synthase subunit Kei1 HSA PF07529.13 EFA75066.1 - 1.2 9.5 5.6 1.7 9.0 0.1 3.8 3 0 0 3 3 3 0 HSA DUF4277 PF14104.6 EFA75067.1 - 0.0022 18.3 0.2 0.022 15.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4277) DUF3439 PF11921.8 EFA75067.1 - 0.062 13.3 1.0 0.16 11.9 1.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ribosomal_L27A PF00828.19 EFA75067.1 - 0.45 11.2 4.0 1.3 9.7 1.6 2.9 2 1 1 3 3 3 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A O-antigen_lig PF13425.6 EFA75069.1 - 1.4 7.6 12.6 3 6.5 12.6 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Phage_Gp23 PF10669.9 EFA75069.1 - 1.7 9.0 16.7 3.5 8.0 13.3 2.5 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) FAM176 PF14851.6 EFA75069.1 - 2 8.1 8.5 4.1 7.1 8.5 1.4 1 0 0 1 1 1 0 FAM176 family tRNA_synt_1c_R2 PF04557.15 EFA75069.1 - 3.3 8.7 18.4 8.7 7.3 18.4 1.7 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Connexin PF00029.19 EFA75069.1 - 4.7 6.9 8.5 8.4 6.1 8.5 1.3 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 EFA75069.1 - 6.4 5.5 10.6 11 4.7 10.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter EIIBC-GUT_N PF03612.14 EFA75069.1 - 7.9 6.2 6.8 16 5.1 6.8 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3915 PF13054.6 EFA75069.1 - 9.4 6.2 8.2 25 4.8 8.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Ecl1 PF12855.7 EFA75070.1 - 5 8.2 28.1 6.7 7.8 28.1 1.2 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins OrfB_Zn_ribbon PF07282.11 EFA75072.1 - 1.1e-06 28.4 0.8 0.00036 20.4 0.1 2.4 2 0 0 2 2 2 2 Putative transposase DNA-binding domain Mucin PF01456.17 EFA75072.1 - 0.71 9.9 14.7 1.4 8.9 14.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DDE_Tnp_1_7 PF13843.6 EFA75073.1 - 4.6e-27 95.2 1.0 7.8e-27 94.5 1.0 1.3 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1 PF01609.21 EFA75073.1 - 0.0086 15.7 0.0 0.026 14.2 0.0 1.9 1 1 0 1 1 1 1 Transposase DDE domain RPN2_C PF18004.1 EFA75073.1 - 0.015 15.2 0.2 0.032 14.2 0.2 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4558 PF15104.6 EFA75073.1 - 2.1 8.5 0.0 2.1 8.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) TPR_1 PF00515.28 EFA75074.1 - 8e-16 57.1 3.0 4.8e-05 23.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75074.1 - 4.4e-13 48.2 3.0 0.0016 18.4 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA75074.1 - 1.5e-08 34.8 4.2 0.00059 20.1 0.6 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA75074.1 - 8.3e-07 28.7 5.3 0.008 16.3 0.1 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA75074.1 - 0.0039 17.1 1.1 1.4 9.1 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFA75074.1 - 0.0064 15.9 2.1 0.28 10.7 0.1 3.3 4 0 0 4 4 4 1 SHNi-TPR TPR_14 PF13428.6 EFA75074.1 - 0.009 16.8 0.9 0.45 11.5 0.7 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75074.1 - 0.01 15.5 2.8 2.9 7.7 0.2 2.9 2 0 0 2 2 2 0 TPR repeat MAS20 PF02064.15 EFA75074.1 - 0.012 15.7 2.6 0.012 15.7 2.6 1.9 2 1 0 2 2 2 0 MAS20 protein import receptor MIT PF04212.18 EFA75074.1 - 0.015 15.3 0.4 0.015 15.3 0.4 3.6 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 EFA75074.1 - 0.11 12.2 12.0 0.03 14.0 4.9 2.7 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_9 PF13371.6 EFA75074.1 - 0.13 12.4 0.4 0.26 11.5 0.4 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA75074.1 - 1.2 9.9 3.6 45 5.0 0.1 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF4201 PF13870.6 EFA75075.1 - 0.00016 21.5 9.1 0.00022 21.0 9.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) ADIP PF11559.8 EFA75075.1 - 0.00022 21.3 11.2 0.00029 20.9 11.2 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding ERM PF00769.19 EFA75075.1 - 0.0031 17.4 8.1 0.0042 16.9 8.1 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Golgin_A5 PF09787.9 EFA75075.1 - 0.0096 15.4 9.3 0.014 14.9 9.3 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Sec8_exocyst PF04048.14 EFA75075.1 - 0.064 13.1 11.2 0.028 14.3 7.8 1.8 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF4200 PF13863.6 EFA75075.1 - 0.075 13.4 14.0 0.098 13.1 14.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Spc7 PF08317.11 EFA75075.1 - 0.09 11.6 12.0 0.12 11.2 12.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Prp19 PF08606.11 EFA75075.1 - 0.097 12.7 6.4 0.065 13.2 4.3 1.8 1 1 1 2 2 2 0 Prp19/Pso4-like FapA PF03961.13 EFA75075.1 - 0.16 10.5 9.2 0.17 10.4 9.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 EFA75075.1 - 0.21 9.5 6.1 0.21 9.4 6.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EFA75075.1 - 0.21 10.9 6.1 0.31 10.3 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Lip_prot_lig_C PF10437.9 EFA75075.1 - 0.21 11.6 2.0 0.96 9.5 0.2 2.5 2 1 1 3 3 3 0 Bacterial lipoate protein ligase C-terminus Tn7_Tnp_TnsA_C PF08721.11 EFA75075.1 - 0.23 12.1 5.4 0.82 10.4 0.6 2.2 2 0 0 2 2 2 0 TnsA endonuclease C terminal DUF641 PF04859.12 EFA75075.1 - 0.36 11.2 11.3 1.5 9.2 11.2 1.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4355 PF14265.6 EFA75075.1 - 0.37 11.0 15.8 3.1 8.0 4.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4355) Fib_alpha PF08702.10 EFA75075.1 - 0.4 10.9 11.1 0.65 10.2 11.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family KfrA_N PF11740.8 EFA75075.1 - 0.41 11.3 5.5 0.39 11.4 1.5 2.0 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term CENP-H PF05837.12 EFA75075.1 - 0.42 11.0 14.7 0.91 10.0 12.1 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) XkdW PF09636.10 EFA75075.1 - 0.57 10.3 9.4 2.4 8.3 1.3 2.7 1 1 2 3 3 3 0 XkdW protein ABC_tran_CTD PF16326.5 EFA75075.1 - 0.92 9.8 11.3 1 9.6 5.3 2.3 1 1 2 3 3 3 0 ABC transporter C-terminal domain Tup_N PF08581.10 EFA75075.1 - 1.1 9.6 12.5 2.2 8.6 12.5 1.6 1 1 0 1 1 1 0 Tup N-terminal TMPIT PF07851.13 EFA75075.1 - 1.4 8.1 9.0 1.5 8.0 9.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein TFR_dimer PF04253.15 EFA75075.1 - 1.5 8.9 6.1 1.5 8.9 3.3 1.9 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain LMBR1 PF04791.16 EFA75075.1 - 2 7.2 8.1 2.4 7.0 8.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein NPV_P10 PF05531.12 EFA75075.1 - 5.3 7.6 11.3 13 6.4 11.2 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein HALZ PF02183.18 EFA75075.1 - 6.1 7.1 15.4 7.7 6.8 6.7 3.4 1 1 2 3 3 3 0 Homeobox associated leucine zipper DUF4404 PF14357.6 EFA75075.1 - 6.6 7.4 12.0 32 5.3 8.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF3450 PF11932.8 EFA75075.1 - 6.9 5.9 14.8 14 4.9 14.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.15 EFA75075.1 - 7 6.5 16.9 1.2 8.9 1.4 2.9 1 1 2 3 3 3 0 Septum formation initiator OmpH PF03938.14 EFA75075.1 - 7.4 6.9 18.2 1.1e+02 3.1 18.2 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) YabA PF06156.13 EFA75075.1 - 10 6.9 13.6 6.2 7.5 6.9 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Rhodanese PF00581.20 EFA75076.1 - 0.0053 17.3 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain zf-C3H1 PF10650.9 EFA75077.1 - 2e-08 33.8 1.2 4.6e-08 32.6 1.2 1.7 1 0 0 1 1 1 1 Putative zinc-finger domain ABC2_membrane_2 PF12679.7 EFA75077.1 - 2.1 7.6 3.6 6 6.1 3.6 1.8 1 0 0 1 1 1 0 ABC-2 family transporter protein Pkinase_Tyr PF07714.17 EFA75078.1 - 3.3e-50 170.8 0.0 6.2e-50 169.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75078.1 - 8.7e-45 153.1 0.0 4.4e-44 150.8 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain C1_1 PF00130.22 EFA75078.1 - 3.4e-06 26.8 0.4 7.5e-06 25.7 0.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) F-box PF00646.33 EFA75078.1 - 2.6e-05 24.0 0.5 8.1e-05 22.4 0.5 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA75078.1 - 7.3e-05 22.6 0.1 0.00017 21.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like Kinase-like PF14531.6 EFA75078.1 - 0.00018 20.9 0.0 0.00049 19.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFA75078.1 - 0.0029 16.4 0.8 0.0046 15.8 0.0 1.7 2 1 0 2 2 2 1 Fungal protein kinase zf-RING_9 PF13901.6 EFA75078.1 - 0.0067 16.4 3.7 0.021 14.8 3.7 1.9 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon PHD PF00628.29 EFA75078.1 - 0.0093 15.8 5.8 0.02 14.8 5.8 1.5 1 0 0 1 1 1 1 PHD-finger APH PF01636.23 EFA75078.1 - 0.0093 15.9 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Colipase-like PF15083.6 EFA75078.1 - 0.037 14.1 1.9 0.084 13.0 1.0 2.0 2 0 0 2 2 1 0 Colipase-like Zn_ribbon_17 PF17120.5 EFA75078.1 - 0.11 12.1 4.2 0.29 10.8 4.2 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD_2 PF13831.6 EFA75078.1 - 0.14 11.8 6.1 0.36 10.4 6.1 1.7 1 0 0 1 1 1 0 PHD-finger WH2 PF02205.20 EFA75079.1 - 7.3e-07 28.8 0.0 0.25 11.2 0.0 3.2 3 0 0 3 3 3 3 WH2 motif bVLRF1 PF18826.1 EFA75080.1 - 5.9e-43 146.3 0.0 1.6e-41 141.7 0.0 2.5 2 1 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_2 PF12796.7 EFA75080.1 - 8.4e-15 55.1 0.0 1.6e-10 41.4 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) VATC PF18716.1 EFA75080.1 - 4.5e-11 42.4 0.8 9e-11 41.4 0.8 1.5 1 0 0 1 1 1 1 Vms1-associating treble clef domain Ank_3 PF13606.6 EFA75080.1 - 8.6e-10 38.0 0.0 0.00054 20.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFA75080.1 - 1.9e-08 34.7 0.0 0.0015 19.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75080.1 - 8.6e-08 32.3 0.0 2.5e-05 24.5 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA75080.1 - 5.9e-06 26.5 0.0 0.0011 19.3 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat zf-MYND PF01753.18 EFA75080.1 - 0.078 13.1 0.4 0.078 13.1 0.4 2.0 2 0 0 2 2 2 0 MYND finger CBF PF03914.17 EFA75080.1 - 2.9 7.9 5.8 0.88 9.6 2.5 1.8 2 0 0 2 2 2 0 CBF/Mak21 family V_ATPase_I PF01496.19 EFA75080.1 - 3.5 5.4 6.1 2.6 5.9 1.6 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PHD PF00628.29 EFA75081.1 - 7.1e-12 45.0 10.9 1.7e-11 43.8 10.9 1.7 1 0 0 1 1 1 1 PHD-finger zinc_ribbon_10 PF10058.9 EFA75081.1 - 0.48 10.2 5.5 1.7 8.4 5.6 1.9 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-RING_2 PF13639.6 EFA75081.1 - 4.5 7.7 6.7 10 6.6 6.7 1.6 1 0 0 1 1 1 0 Ring finger domain VSP PF03302.13 EFA75082.1 - 0.032 13.1 2.3 0.052 12.4 2.3 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF1579 PF07617.11 EFA75082.1 - 0.15 12.0 0.4 0.35 10.8 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1579) Beta-APP PF03494.13 EFA75082.1 - 0.19 11.6 3.4 0.63 9.9 3.4 2.0 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) DUF5012 PF16404.5 EFA75082.1 - 3 8.0 7.3 1.1 9.4 0.6 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5012) Romo1 PF10247.9 EFA75083.1 - 4.3e-16 59.0 19.8 5.8e-16 58.6 19.8 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Glug PF07581.12 EFA75083.1 - 5.3 7.7 6.2 30 5.3 0.2 2.7 1 1 1 2 2 2 0 The GLUG motif ZZ PF00569.17 EFA75084.1 - 5.7e-13 48.5 3.2 9.2e-13 47.8 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 EFA75084.1 - 5.2e-11 42.6 0.2 5.2e-11 42.6 0.2 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA75084.1 - 1.8e-05 24.9 0.6 7.3e-05 22.9 0.3 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain C1_2 PF03107.16 EFA75084.1 - 0.074 13.4 4.1 0.15 12.4 4.1 1.5 1 0 0 1 1 1 0 C1 domain Menin PF05053.13 EFA75084.1 - 0.16 10.3 13.2 0.072 11.5 3.0 2.1 2 0 0 2 2 2 0 Menin Presenilin PF01080.17 EFA75084.1 - 1.5 7.5 7.5 2.8 6.6 0.3 2.1 2 0 0 2 2 2 0 Presenilin Apt1 PF10351.9 EFA75084.1 - 4.5 6.0 17.1 0.81 8.5 2.7 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain zf-RING_2 PF13639.6 EFA75085.1 - 4.9e-09 36.4 9.1 7.8e-09 35.7 9.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA75085.1 - 6e-09 35.6 7.7 9.7e-09 34.9 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA75085.1 - 2e-08 33.9 7.6 3.5e-08 33.2 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA75085.1 - 6.3e-07 29.2 5.2 1e-06 28.5 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA75085.1 - 1.8e-06 27.9 6.4 3.6e-06 26.9 6.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFA75085.1 - 4.1e-05 23.8 9.9 0.00015 22.0 9.9 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFA75085.1 - 6.4e-05 22.7 8.2 0.00018 21.3 8.2 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFA75085.1 - 8.7e-05 22.4 6.6 0.00015 21.7 6.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFA75085.1 - 0.0019 18.3 7.2 0.0049 17.0 7.3 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EFA75085.1 - 0.0036 17.1 3.1 0.0067 16.3 3.1 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein AT_hook PF02178.19 EFA75085.1 - 0.014 15.2 0.6 0.048 13.5 0.6 2.0 1 0 0 1 1 1 0 AT hook motif zf-ANAPC11 PF12861.7 EFA75085.1 - 0.034 14.2 2.0 0.066 13.3 2.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFA75085.1 - 0.05 13.2 4.0 0.093 12.4 4.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-MIZ PF02891.20 EFA75085.1 - 0.05 13.4 8.0 0.14 12.0 8.0 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger DZR PF12773.7 EFA75085.1 - 0.052 13.6 3.9 0.1 12.6 3.9 1.4 1 0 0 1 1 1 0 Double zinc ribbon Mab-21 PF03281.14 EFA75085.1 - 0.089 12.1 0.2 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Mab-21 protein zf-P11 PF03854.14 EFA75085.1 - 0.097 12.3 4.3 0.19 11.4 4.3 1.4 1 0 0 1 1 1 0 P-11 zinc finger zinc-ribbons_6 PF07191.12 EFA75085.1 - 0.14 12.1 2.0 0.24 11.4 2.0 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-RING_4 PF14570.6 EFA75085.1 - 0.32 10.8 7.1 0.93 9.3 7.1 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EFA75085.1 - 0.78 9.9 3.0 1.4 9.2 3.0 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1272 PF06906.11 EFA75085.1 - 0.92 9.7 5.0 1.8 8.7 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-Nse PF11789.8 EFA75085.1 - 2.1 8.2 5.6 4.3 7.2 5.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit HrpB7 PF09486.10 EFA75086.1 - 0.044 14.2 7.8 0.08 13.3 7.8 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF4611 PF15387.6 EFA75086.1 - 8.5 6.7 11.9 0.13 12.5 3.4 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) HAD_2 PF13419.6 EFA75087.1 - 9.4e-09 35.6 0.1 0.00013 22.1 0.1 2.2 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFA75087.1 - 1.7e-05 24.8 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFA75087.1 - 5.1e-05 23.7 0.1 0.022 15.0 0.1 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EFA75087.1 - 0.011 15.6 0.0 1 9.2 0.0 2.1 1 1 0 2 2 2 0 Acid Phosphatase Lipoprotein_X PF03305.13 EFA75087.1 - 0.12 12.2 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein Abhydrolase_2 PF02230.16 EFA75088.1 - 2.8e-28 99.2 0.0 4.7e-28 98.5 0.0 1.3 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFA75088.1 - 1e-05 26.2 0.0 3.7e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA75088.1 - 0.00014 21.6 0.2 0.001 18.8 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 EFA75088.1 - 0.00018 21.1 0.0 0.00029 20.5 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EFA75088.1 - 0.001 18.6 0.6 0.029 13.8 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFA75088.1 - 0.0011 18.2 1.1 0.64 9.2 0.0 2.8 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DUF2974 PF11187.8 EFA75088.1 - 0.0014 18.3 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) FSH1 PF03959.13 EFA75088.1 - 0.022 14.4 0.0 0.25 11.0 0.0 2.3 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Lipase_3 PF01764.25 EFA75088.1 - 0.025 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Ank_4 PF13637.6 EFA75089.1 - 3.4e-24 84.9 9.0 0.0002 21.8 0.0 7.1 6 2 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75089.1 - 2.7e-23 81.7 10.1 0.0018 18.5 0.0 8.6 3 1 6 9 9 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75089.1 - 1e-20 74.1 9.0 1.5e-07 31.9 0.0 4.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75089.1 - 6.7e-14 50.6 2.6 0.036 14.6 0.0 8.5 8 1 1 9 9 9 3 Ankyrin repeat DUF5049 PF16468.5 EFA75089.1 - 0.00014 21.7 0.1 9.3 6.2 0.0 5.6 4 1 3 7 7 7 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA75089.1 - 0.0011 19.3 1.7 37 5.0 0.0 5.6 4 3 2 6 6 6 0 Ankyrin repeat Resolvase PF00239.21 EFA75089.1 - 0.046 13.8 0.0 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Resolvase, N terminal domain Adenylsucc_synt PF00709.21 EFA75090.1 - 1.7e-180 600.5 0.1 1.9e-180 600.3 0.1 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DSPc PF00782.20 EFA75090.1 - 0.072 12.9 0.1 0.97 9.2 0.0 2.2 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Ras PF00071.22 EFA75091.1 - 7.4e-60 201.2 0.1 9e-60 200.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75091.1 - 8.9e-34 116.3 0.0 1.3e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75091.1 - 7.3e-15 54.8 0.0 9.4e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA75091.1 - 1.3e-05 25.2 0.1 0.045 13.7 0.0 2.1 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFA75091.1 - 0.00029 20.3 0.1 0.00033 20.1 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA75091.1 - 0.0014 18.7 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA75091.1 - 0.0058 16.2 0.1 0.033 13.7 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFA75091.1 - 0.0068 15.9 0.0 0.043 13.3 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_7 PF12775.7 EFA75091.1 - 0.018 14.6 0.0 0.19 11.2 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EFA75091.1 - 0.021 14.6 0.1 0.18 11.6 0.0 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EFA75091.1 - 0.048 13.1 0.1 0.064 12.7 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EFA75091.1 - 0.076 12.4 0.0 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 EFA75091.1 - 0.08 13.3 0.0 0.11 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFA75091.1 - 0.09 13.0 0.0 0.2 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFA75091.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Glyco_transf_41 PF13844.6 EFA75092.1 - 6.2e-50 170.0 0.6 5e-24 84.6 0.0 2.3 1 1 1 2 2 2 2 Glycosyl transferase family 41 TPR_20 PF14561.6 EFA75092.1 - 0.00011 22.4 1.1 0.023 15.0 0.1 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.8 EFA75092.1 - 0.00065 18.7 0.5 0.001 18.1 0.5 1.2 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 EFA75092.1 - 0.0022 18.3 0.0 2.1 8.9 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75092.1 - 0.015 15.3 0.0 4.9 7.5 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA75092.1 - 0.19 12.3 0.1 3.1 8.4 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Ipi1_N PF12333.8 EFA75093.1 - 7.4e-14 52.2 8.8 1.3e-11 45.0 0.5 4.7 4 1 1 5 5 5 2 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.7 EFA75093.1 - 0.03 14.9 0.0 0.95 10.1 0.0 3.4 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region FAD_SOX PF18371.1 EFA75093.1 - 0.84 10.0 3.9 29 5.1 0.1 3.0 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Secretin_N_2 PF07655.13 EFA75093.1 - 2 9.0 9.5 12 6.5 0.8 3.1 2 0 0 2 2 2 0 Secretin N-terminal domain FNIP PF05725.12 EFA75094.1 - 9e-23 80.2 40.2 0.0014 18.8 0.1 11.0 7 3 2 10 10 10 8 FNIP Repeat AcetylCoA_hydro PF02550.15 EFA75097.1 - 1.2e-44 152.7 0.0 2.4e-44 151.7 0.0 1.5 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EFA75097.1 - 5.7e-38 130.3 0.0 8.9e-38 129.6 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.12 EFA75097.1 - 0.11 11.3 0.0 0.29 10.0 0.0 1.5 1 1 0 1 1 1 0 Citrate lyase, alpha subunit (CitF) TPR_8 PF13181.6 EFA75098.1 - 4.4e-13 48.3 7.8 0.00037 20.5 0.1 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75098.1 - 3.4e-12 45.5 9.0 0.005 16.9 0.1 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFA75098.1 - 1.6e-08 34.6 0.1 0.0008 20.0 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA75098.1 - 8.4e-08 32.7 0.0 6.4e-05 23.5 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 EFA75098.1 - 6.3e-07 29.6 0.6 0.093 13.1 0.1 4.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA75098.1 - 1e-06 29.0 2.3 0.011 16.3 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA75098.1 - 1.6e-06 27.6 2.9 0.0058 16.4 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA75098.1 - 6e-06 26.5 9.0 0.028 14.7 0.6 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA75098.1 - 7.2e-06 26.4 3.5 7.5e-05 23.2 0.4 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA75098.1 - 1.9e-05 24.7 3.1 10 6.8 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75098.1 - 6.7e-05 22.5 5.3 10 5.9 0.1 5.5 5 0 0 5 5 5 0 TPR repeat TPR_7 PF13176.6 EFA75098.1 - 6.9e-05 22.6 8.2 0.42 10.7 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat NARP1 PF12569.8 EFA75098.1 - 0.0044 16.0 0.7 0.016 14.1 0.2 2.2 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 Vps39_1 PF10366.9 EFA75098.1 - 0.017 15.4 5.8 0.027 14.8 0.6 3.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_15 PF13429.6 EFA75098.1 - 0.021 14.1 0.2 0.19 10.9 0.3 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA75098.1 - 0.042 13.7 1.3 28 4.8 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5588 PF17826.1 EFA75098.1 - 0.048 12.5 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5588) ANAPC3 PF12895.7 EFA75098.1 - 0.078 13.2 6.3 0.2 11.9 0.5 3.6 4 1 0 4 4 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFA75098.1 - 0.13 12.4 0.0 0.37 11.0 0.0 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA75098.1 - 0.16 12.0 2.2 0.17 12.0 0.3 2.1 2 0 0 2 2 1 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFA75098.1 - 0.21 11.6 1.7 0.91 9.6 1.0 2.6 2 1 0 2 2 1 0 MIT (microtubule interacting and transport) domain GREB1 PF15782.5 EFA75099.1 - 0.0049 14.1 4.8 0.0058 13.8 4.8 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer RRN3 PF05327.11 EFA75099.1 - 0.037 12.6 19.1 0.049 12.2 19.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.12 EFA75099.1 - 0.45 9.9 25.7 0.58 9.5 25.7 1.1 1 0 0 1 1 1 0 SDA1 Rhabdo_ncap PF00945.18 EFA75099.1 - 1.7 7.5 7.2 2.9 6.7 7.2 1.4 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein PDCD2_C PF04194.13 EFA75099.1 - 3.8 7.6 14.2 15 5.6 0.4 2.2 1 1 1 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain Menin PF05053.13 EFA75099.1 - 6.8 4.9 10.8 8.5 4.6 10.8 1.1 1 0 0 1 1 1 0 Menin FOXP-CC PF16159.5 EFA75100.1 - 0.041 14.5 0.6 0.041 14.5 0.6 4.8 5 1 0 5 5 5 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EFA75100.1 - 0.36 11.8 31.0 1.2 10.2 3.3 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger RRM_1 PF00076.22 EFA75101.1 - 8.3e-15 54.4 0.1 1.4e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA75101.1 - 1.1e-06 28.7 0.0 4.4e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif SR-25 PF10500.9 EFA75101.1 - 0.15 11.6 15.1 0.25 10.9 15.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 EFA75102.1 - 0.0081 16.2 4.9 1 9.4 0.1 2.7 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 MFS_1 PF07690.16 EFA75103.1 - 1.5e-15 57.0 28.8 1.5e-15 57.0 28.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TIG PF01833.24 EFA75104.1 - 1.7e-22 79.3 35.8 9.1e-06 25.7 3.8 7.4 6 1 0 7 7 7 5 IPT/TIG domain TMEM154 PF15102.6 EFA75104.1 - 1.1e-05 25.4 0.1 2.2e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 TMEM154 protein family DUF3188 PF11384.8 EFA75104.1 - 0.082 12.6 0.2 0.19 11.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) DAG1 PF05454.11 EFA75104.1 - 2.9 7.2 8.1 1.8 7.8 0.2 2.9 3 0 0 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DIM PF08194.12 EFA75104.1 - 7.5 6.8 5.7 54 4.1 0.1 3.5 3 0 0 3 3 3 0 DIM protein Abhydrolase_1 PF00561.20 EFA75105.1 - 2.8e-16 59.9 0.1 2.7e-14 53.4 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA75105.1 - 7.8e-15 54.8 0.0 2.4e-14 53.2 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFA75105.1 - 0.011 15.3 0.0 0.058 12.9 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 EFA75105.1 - 0.023 14.4 0.1 0.12 12.0 0.0 2.2 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 EFA75105.1 - 0.025 14.3 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EFA75105.1 - 0.031 13.9 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Lipase_3 PF01764.25 EFA75105.1 - 0.045 13.6 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_4 PF08386.10 EFA75105.1 - 0.051 13.7 0.0 0.23 11.6 0.0 2.2 3 0 0 3 3 3 0 TAP-like protein VirJ PF06057.11 EFA75105.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 1 0 1 1 1 0 Bacterial virulence protein (VirJ) Syja_N PF02383.18 EFA75106.1 - 1.2e-81 274.5 1.7 1.2e-81 274.5 1.7 3.4 3 1 0 3 3 3 1 SacI homology domain hSac2 PF12456.8 EFA75106.1 - 1.1e-24 86.4 0.2 2.9e-24 85.0 0.2 1.8 1 0 0 1 1 1 1 Inositol phosphatase Pkinase PF00069.25 EFA75107.1 - 1.7e-52 178.4 0.1 1.3e-51 175.6 0.1 2.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75107.1 - 2.3e-26 92.7 0.4 1e-25 90.5 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Spc7 PF08317.11 EFA75107.1 - 0.0014 17.6 19.7 0.0014 17.6 19.7 5.6 4 2 1 5 5 5 4 Spc7 kinetochore protein APH PF01636.23 EFA75107.1 - 0.011 15.7 3.3 0.16 11.9 0.0 2.8 3 1 0 3 3 3 0 Phosphotransferase enzyme family PKcGMP_CC PF16808.5 EFA75107.1 - 0.76 9.7 7.1 8.9 6.3 0.6 3.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2937 PF11157.8 EFA75107.1 - 5.8 6.6 10.6 6 6.6 8.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) DUF3752 PF12572.8 EFA75108.1 - 9.3e-21 74.9 19.7 9.3e-21 74.9 19.7 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3752) RasGEF PF00617.19 EFA75110.1 - 5.1e-31 108.2 1.8 1.6e-30 106.6 1.8 2.0 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA75110.1 - 4e-17 62.4 2.5 6.9e-17 61.6 0.7 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif FATC PF02260.20 EFA75110.1 - 0.011 15.5 0.6 10 6.1 0.5 3.0 2 0 0 2 2 2 0 FATC domain Pribosyltran_N PF13793.6 EFA75111.1 - 1.9e-46 156.8 1.6 8e-46 154.7 0.1 2.4 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFA75111.1 - 7.6e-32 110.8 5.1 3.4e-30 105.5 0.9 3.1 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFA75111.1 - 1e-07 31.6 1.9 2.3e-07 30.5 1.6 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain DeoRC PF00455.22 EFA75111.1 - 0.026 14.4 0.1 0.54 10.2 0.0 2.5 2 0 0 2 2 2 0 DeoR C terminal sensor domain Methyltransf_18 PF12847.7 EFA75111.1 - 0.027 14.4 0.5 0.061 13.3 0.2 1.8 2 0 0 2 2 2 0 Methyltransferase domain p450 PF00067.22 EFA75112.1 - 0.0097 14.7 1.1 0.019 13.7 0.0 2.1 2 0 0 2 2 2 1 Cytochrome P450 Xpo1 PF08389.12 EFA75112.1 - 0.049 13.7 0.3 0.049 13.7 0.3 5.0 3 2 3 6 6 6 0 Exportin 1-like protein Mito_carr PF00153.27 EFA75113.1 - 5.4e-64 212.2 6.6 2.4e-20 72.3 0.2 3.4 4 0 0 4 4 4 3 Mitochondrial carrier protein TraT PF05818.12 EFA75113.1 - 0.29 10.8 4.2 0.24 11.1 0.4 2.1 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DUF2835 PF11197.8 EFA75113.1 - 0.32 10.8 2.5 45 4.0 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2835) Complex1_LYR PF05347.15 EFA75114.1 - 0.0001 22.3 2.5 0.00012 22.1 0.3 2.2 2 2 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFA75114.1 - 0.0045 17.7 1.3 0.0091 16.7 1.2 1.7 1 1 0 1 1 1 1 Complex1_LYR-like RRM_1 PF00076.22 EFA75115.1 - 1.3e-15 56.9 0.1 2.6e-15 56.0 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA75115.1 - 2.3e-05 24.0 0.0 2.6e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA75115.1 - 0.045 13.6 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif DLP_helical PF18709.1 EFA75117.1 - 0.15 11.2 1.2 0.23 10.6 1.2 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain Oxidored-like PF09791.9 EFA75118.1 - 5.7e-15 54.7 1.7 1.3e-14 53.5 1.7 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF5522 PF17653.1 EFA75118.1 - 0.0095 15.9 5.5 0.022 14.7 5.5 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5522) OSK PF17182.4 EFA75118.1 - 0.025 13.8 1.4 0.04 13.2 1.4 1.3 1 0 0 1 1 1 0 OSK domain TIG PF01833.24 EFA75119.1 - 5.4e-23 80.9 42.5 4.8e-07 29.8 4.2 7.2 5 1 1 6 6 6 6 IPT/TIG domain EGF_2 PF07974.13 EFA75119.1 - 1.9e-06 28.2 39.8 0.00027 21.2 13.0 3.0 3 0 0 3 3 3 2 EGF-like domain EGF_Tenascin PF18720.1 EFA75119.1 - 0.00038 20.4 8.9 0.00038 20.4 8.9 2.7 2 0 0 2 2 2 1 Tenascin EGF domain EGF PF00008.27 EFA75119.1 - 0.035 14.4 22.5 0.28 11.5 7.1 2.8 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 EFA75119.1 - 0.3 11.8 20.4 2.1 9.1 4.9 3.0 2 0 0 2 2 2 0 Human growth factor-like EGF Laminin_EGF PF00053.24 EFA75119.1 - 9.8 6.4 23.5 14 5.9 9.8 2.6 2 0 0 2 2 2 0 Laminin EGF domain FNIP PF05725.12 EFA75120.1 - 4.1e-07 30.1 2.0 0.0079 16.3 0.1 2.1 1 1 1 2 2 2 2 FNIP Repeat FNIP PF05725.12 EFA75121.1 - 3.2e-52 174.4 74.7 5.6e-05 23.2 0.2 18.9 11 4 6 19 19 19 14 FNIP Repeat AMPKBI PF04739.15 EFA75121.1 - 0.79 10.0 10.6 5.5 7.3 0.2 4.6 5 0 0 5 5 5 0 5'-AMP-activated protein kinase beta subunit, interaction domain FNIP PF05725.12 EFA75122.1 - 1.8e-26 92.0 25.5 0.0013 18.9 0.0 10.3 6 2 5 12 12 12 11 FNIP Repeat FNIP PF05725.12 EFA75123.1 - 1.8e-23 82.4 38.8 7.1e-05 22.9 0.2 9.7 7 3 3 10 10 10 8 FNIP Repeat LRR_5 PF13306.6 EFA75123.1 - 0.0019 18.2 16.1 0.56 10.2 0.4 4.9 3 2 2 5 5 5 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EFA75123.1 - 0.044 14.2 29.8 1.4 9.4 3.1 7.1 5 2 0 5 5 5 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 EFA75124.1 - 4e-17 62.1 31.6 1.7e-07 31.3 2.2 8.2 8 1 0 8 8 8 4 FNIP Repeat F-box_5 PF18511.1 EFA75124.1 - 0.00014 21.3 0.6 0.00029 20.4 0.6 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75124.1 - 0.00039 20.2 0.2 0.00099 19.0 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75124.1 - 0.0098 15.7 0.6 0.031 14.1 0.6 1.8 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EFA75124.1 - 2.1 8.6 5.1 53 4.2 0.0 4.8 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EFA75124.1 - 6.2 7.8 19.4 2 9.3 0.1 7.4 6 2 0 6 6 6 0 Leucine Rich Repeat LETM1 PF07766.13 EFA75125.1 - 1.1e-14 54.4 0.7 1.1e-14 54.4 0.7 1.7 2 0 0 2 2 2 1 LETM1-like protein ATG11 PF10377.9 EFA75125.1 - 0.006 16.6 1.8 0.093 12.8 0.1 2.9 3 0 0 3 3 3 1 Autophagy-related protein 11 Menin PF05053.13 EFA75125.1 - 1.3 7.3 5.2 1.8 6.9 5.2 1.1 1 0 0 1 1 1 0 Menin ATG16 PF08614.11 EFA75125.1 - 1.3 9.2 6.3 0.26 11.5 2.3 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) YMF19 PF02326.15 EFA75125.1 - 4.5 8.1 9.7 0.42 11.4 0.2 2.7 2 1 1 3 3 3 0 Plant ATP synthase F0 Sec7 PF01369.20 EFA75126.1 - 1.5e-50 171.4 7.6 2.7e-50 170.6 3.7 3.0 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EFA75126.1 - 1.9e-20 73.3 0.3 1.9e-20 73.3 0.3 4.8 4 1 1 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Importin_rep_3 PF18806.1 EFA75126.1 - 0.045 13.8 0.0 0.58 10.2 0.0 3.0 2 0 0 2 2 2 0 Importin 13 repeat DUF1563 PF07599.11 EFA75126.1 - 1.3 9.2 7.4 0.61 10.2 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1563) Pyridoxal_deC PF00282.19 EFA75127.1 - 0.063 12.0 0.4 0.08 11.6 0.4 1.0 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain IBN_N PF03810.19 EFA75128.1 - 6e-05 22.9 2.1 0.00013 21.8 2.1 1.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain DNA_alkylation PF08713.11 EFA75128.1 - 0.036 13.8 0.1 0.047 13.4 0.1 1.2 1 0 0 1 1 1 0 DNA alkylation repair enzyme Ribosomal_L27A PF00828.19 EFA75129.1 - 1.1e-20 74.5 0.0 1.5e-20 74.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF5026 PF16429.5 EFA75129.1 - 0.11 12.6 0.3 0.2 11.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5026) ATG27 PF09451.10 EFA75130.1 - 7.9e-36 124.3 1.4 1.5e-35 123.3 1.4 1.4 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFA75130.1 - 2.7e-15 56.1 0.2 3.8e-15 55.7 0.2 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 EFA75130.1 - 0.0043 16.8 0.3 0.0071 16.0 0.3 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EFA75131.1 - 5.2e-40 138.0 1.0 8.4e-40 137.3 1.0 1.3 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFA75131.1 - 1.4e-08 34.2 0.9 3.1e-08 33.0 0.9 1.4 1 1 0 1 1 1 1 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 EFA75131.1 - 1.6e-07 31.1 0.1 2.4e-07 30.5 0.1 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA75131.1 - 0.0014 18.7 0.5 0.0014 18.7 0.5 1.5 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat Consortin_C PF15281.6 EFA75131.1 - 0.43 10.6 2.1 27 4.8 0.0 2.7 3 0 0 3 3 3 0 Consortin C-terminus ATG27 PF09451.10 EFA75132.1 - 4.1e-37 128.5 5.1 1.1e-36 127.1 5.1 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFA75132.1 - 2.9e-11 42.9 4.1 8.1e-08 31.7 0.1 2.1 2 0 0 2 2 2 2 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 EFA75132.1 - 1.6e-06 27.9 2.4 6.8e-06 25.9 0.1 2.4 1 1 2 3 3 3 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA75132.1 - 1.2e-05 25.4 7.2 0.00024 21.2 2.0 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATP1G1_PLM_MAT8 PF02038.16 EFA75132.1 - 2 7.9 5.6 5.1 6.6 0.1 3.4 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family ABC_tran PF00005.27 EFA75133.1 - 0.00092 19.7 3.0 0.0057 17.2 0.0 3.5 5 0 0 5 5 5 1 ABC transporter Patatin PF01734.22 EFA75133.1 - 0.0011 19.2 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase AAA PF00004.29 EFA75133.1 - 0.0022 18.4 0.0 0.63 10.5 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EFA75133.1 - 0.0037 17.3 0.0 0.02 15.0 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA75133.1 - 0.0045 16.9 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase Transp_Tc5_C PF04236.15 EFA75133.1 - 0.0071 16.7 1.3 0.0071 16.7 1.3 3.3 3 0 0 3 3 2 1 Tc5 transposase C-terminal domain Rad17 PF03215.15 EFA75133.1 - 0.0079 16.1 0.1 0.046 13.6 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 EFA75133.1 - 0.024 14.9 0.1 0.18 12.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 EFA75133.1 - 0.053 13.3 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFA75133.1 - 0.061 13.7 0.5 0.43 11.0 0.0 2.8 3 0 0 3 3 2 0 RNA helicase AAA_16 PF13191.6 EFA75133.1 - 0.085 13.2 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EFA75133.1 - 0.21 11.8 0.0 0.43 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3439 PF11921.8 EFA75133.1 - 2.1 8.3 8.1 4 7.4 6.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Prok-RING_4 PF14447.6 EFA75133.1 - 4.5 7.2 14.0 15 5.6 14.0 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFA75133.1 - 6.2 6.8 21.8 0.056 13.3 12.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MMR_HSR1 PF01926.23 EFA75134.1 - 8.4e-05 22.6 0.0 0.00023 21.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Patatin PF01734.22 EFA75134.1 - 0.00042 20.5 0.0 0.00082 19.6 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase zf-C3HC4_2 PF13923.6 EFA75134.1 - 0.0038 17.0 12.2 0.011 15.5 12.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ABC_tran PF00005.27 EFA75134.1 - 0.0058 17.1 0.0 0.015 15.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter Roc PF08477.13 EFA75134.1 - 0.02 15.1 0.0 0.073 13.3 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EFA75134.1 - 0.034 14.5 0.0 0.082 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFA75134.1 - 0.039 13.9 0.1 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 EFA75134.1 - 0.04 14.0 0.1 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Dynamin family AAA_33 PF13671.6 EFA75134.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Prok-RING_4 PF14447.6 EFA75134.1 - 0.092 12.6 10.0 0.24 11.3 10.0 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFA75134.1 - 0.11 12.4 10.7 0.32 11.0 10.7 1.8 1 0 0 1 1 1 0 zinc-RING finger domain AAA_22 PF13401.6 EFA75134.1 - 0.13 12.5 0.0 0.42 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain zf-C3HC4 PF00097.25 EFA75134.1 - 0.44 10.5 11.2 1.4 8.9 11.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA75134.1 - 2.8 8.1 9.9 9.1 6.4 9.9 1.9 1 0 0 1 1 1 0 RING-type zinc-finger Transp_Tc5_C PF04236.15 EFA75135.1 - 0.0037 17.6 1.9 0.0037 17.6 1.9 2.6 2 0 0 2 2 1 1 Tc5 transposase C-terminal domain zf-C3HC4_3 PF13920.6 EFA75135.1 - 0.0083 16.0 11.7 0.0083 16.0 11.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ABC_tran PF00005.27 EFA75135.1 - 0.015 15.8 0.0 0.043 14.3 0.0 1.8 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 EFA75135.1 - 0.016 15.3 0.0 0.058 13.5 0.0 2.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase Rad17 PF03215.15 EFA75135.1 - 0.036 14.0 0.0 0.16 11.9 0.0 2.1 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EFA75135.1 - 0.041 13.8 0.1 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Viral_helicase1 PF01443.18 EFA75135.1 - 0.049 13.4 1.5 0.1 12.3 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EFA75135.1 - 0.1 13.0 0.0 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Patatin PF01734.22 EFA75135.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Patatin-like phospholipase RuvB_N PF05496.12 EFA75135.1 - 0.17 11.7 0.0 0.44 10.3 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Prok-RING_4 PF14447.6 EFA75135.1 - 0.55 10.1 12.5 1.6 8.6 12.5 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EFA75135.1 - 1.3 9.2 15.4 0.06 13.5 6.9 2.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EFA75135.1 - 7.7 6.6 22.9 0.016 15.1 12.0 2.3 2 0 0 2 2 1 0 zinc-RING finger domain DUF572 PF04502.13 EFA75136.1 - 1.3e-76 258.4 17.7 3.3e-76 257.1 17.7 1.5 1 1 0 1 1 1 1 Family of unknown function (DUF572) E6 PF00518.17 EFA75136.1 - 0.071 13.6 0.6 7.1 7.1 0.4 2.5 1 1 1 2 2 2 0 Early Protein (E6) zf-PHD-like PF15446.6 EFA75136.1 - 0.098 12.3 0.3 0.098 12.3 0.3 2.1 2 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Zn_ribbon_recom PF13408.6 EFA75136.1 - 0.14 12.7 1.5 4.2 8.0 0.1 2.4 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain TF_Zn_Ribbon PF08271.12 EFA75136.1 - 0.16 11.5 0.3 0.16 11.5 0.3 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding RNA_pol_N PF01194.17 EFA75136.1 - 0.97 9.8 3.0 19 5.7 3.0 2.8 1 1 0 1 1 1 0 RNA polymerases N / 8 kDa subunit Rogdi_lz PF10259.9 EFA75137.1 - 1.2e-15 57.7 12.9 3.3e-14 53.0 12.9 2.9 1 1 0 1 1 1 1 Rogdi leucine zipper containing protein DUF4834 PF16118.5 EFA75137.1 - 8.2 7.5 11.2 3.8 8.5 0.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Ribosomal_L5_C PF00673.21 EFA75138.1 - 5.7e-21 74.5 0.0 8.5e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFA75138.1 - 1.2e-18 67.1 0.2 3.5e-18 65.7 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 DUF5052 PF16475.5 EFA75139.1 - 0.0055 16.4 0.0 0.0062 16.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5052) tRNA_anti-codon PF01336.25 EFA75139.1 - 0.064 13.2 0.2 0.092 12.7 0.2 1.4 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain NAD_binding_6 PF08030.12 EFA75140.1 - 0.00033 20.8 0.0 0.00067 19.8 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EFA75140.1 - 0.0012 18.9 9.3 0.0012 18.9 9.3 2.9 2 1 0 2 2 2 1 Ferric reductase like transmembrane component DUF5572 PF17733.1 EFA75140.1 - 0.0067 16.2 2.8 0.013 15.3 2.8 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5572) HNF-1_N PF04814.13 EFA75141.1 - 0.0029 18.3 1.4 0.0035 18.0 1.4 1.1 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus UPF0184 PF03670.13 EFA75141.1 - 0.0037 17.6 0.0 0.0056 17.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) HTH_Tnp_4 PF13613.6 EFA75142.1 - 6.8e-06 25.7 0.2 1.5e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_4 PF13359.6 EFA75143.1 - 7.1e-12 45.3 0.0 8.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA75143.1 - 0.00013 21.6 0.0 0.00019 21.1 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_2 PF13586.6 EFA75143.1 - 0.028 14.8 0.0 0.036 14.4 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain AbiJ_NTD3 PF18860.1 EFA75143.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 AbiJ N-terminal domain 3 NAD_binding_6 PF08030.12 EFA75144.1 - 1e-06 28.9 0.0 4.9e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EFA75144.1 - 0.0087 16.2 13.7 0.03 14.4 12.1 2.5 1 1 1 2 2 2 1 Ferric reductase like transmembrane component Ribosomal_S19e PF01090.19 EFA75145.1 - 2.7e-52 176.1 0.0 3.2e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L21e PF01157.18 EFA75146.1 - 2.6e-43 146.0 3.8 6.6e-43 144.7 3.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L21e Mid2 PF04478.12 EFA75146.1 - 0.14 12.0 1.7 0.22 11.4 1.7 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Kelch_1 PF01344.25 EFA75147.1 - 5.9e-41 137.8 17.9 2.3e-09 36.7 1.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFA75147.1 - 3.4e-38 128.7 22.8 7.2e-09 35.6 0.8 6.9 6 1 1 7 7 7 6 Kelch motif Kelch_5 PF13854.6 EFA75147.1 - 6e-36 121.9 25.6 3e-09 36.7 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFA75147.1 - 1.4e-30 104.9 14.6 4.4e-06 26.8 0.0 7.5 7 1 0 7 7 7 7 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA75147.1 - 1e-26 92.6 12.6 2.6e-06 27.4 1.6 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA75147.1 - 3.3e-25 87.0 18.4 8.6e-06 25.5 0.1 6.7 6 1 0 6 6 6 6 Kelch motif RAG2 PF03089.14 EFA75147.1 - 0.0054 15.8 0.1 0.17 10.8 0.0 2.8 3 0 0 3 3 3 1 Recombination activating protein 2 F-box PF00646.33 EFA75147.1 - 0.015 15.2 0.4 0.03 14.2 0.4 1.5 1 0 0 1 1 1 0 F-box domain CDK2AP PF09806.9 EFA75148.1 - 1.6 8.8 10.8 0.37 10.8 4.1 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Dus PF01207.17 EFA75149.1 - 1.5e-51 175.4 1.9 2.3e-51 174.8 1.4 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Gti1_Pac2 PF09729.9 EFA75149.1 - 0.34 11.0 16.2 0.56 10.3 14.8 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family MID_MedPIWI PF18296.1 EFA75149.1 - 1.3 8.7 13.6 2.2 8.0 13.6 1.3 1 0 0 1 1 1 0 MID domain of medPIWI Menin PF05053.13 EFA75149.1 - 3 6.1 16.4 5.2 5.3 16.4 1.4 1 0 0 1 1 1 0 Menin FNIP PF05725.12 EFA75150.1 - 5.8e-12 45.6 17.4 0.0075 16.4 0.1 8.4 5 1 2 7 7 7 5 FNIP Repeat DCP2 PF05026.13 EFA75150.1 - 0.067 13.5 0.5 0.93 9.9 0.0 2.7 2 0 0 2 2 2 0 Dcp2, box A domain F-box-like PF12937.7 EFA75150.1 - 7.7 6.5 8.0 0.33 10.9 2.1 1.8 2 0 0 2 2 2 0 F-box-like CD34_antigen PF06365.12 EFA75151.1 - 0.14 11.7 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family EGF_2 PF07974.13 EFA75151.1 - 0.16 12.3 10.4 0.32 11.4 10.4 1.5 1 0 0 1 1 1 0 EGF-like domain Cadherin_C_2 PF16492.5 EFA75151.1 - 0.23 12.2 4.0 0.13 13.0 0.4 2.5 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal EGF PF00008.27 EFA75151.1 - 1.6 9.1 9.0 4 7.8 9.0 1.7 1 0 0 1 1 1 0 EGF-like domain Mucin PF01456.17 EFA75152.1 - 0.58 10.1 26.7 0.45 10.5 10.3 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein Ras PF00071.22 EFA75153.1 - 3.7e-50 169.7 0.0 4.3e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75153.1 - 1.5e-21 76.9 0.0 2.4e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75153.1 - 1.1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA75153.1 - 0.0001 22.3 0.0 0.0085 16.0 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EFA75153.1 - 0.0059 16.4 0.1 0.5 10.1 0.1 2.9 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EFA75153.1 - 0.043 13.3 0.0 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA75153.1 - 0.077 12.3 0.0 0.23 10.8 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SR-25 PF10500.9 EFA75153.1 - 0.14 11.7 4.2 0.17 11.4 4.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Vac7 PF12751.7 EFA75154.1 - 0.071 12.5 0.8 0.082 12.3 0.8 1.0 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 PI3_PI4_kinase PF00454.27 EFA75155.1 - 3.8e-53 180.8 0.0 1.3e-52 179.1 0.0 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EFA75155.1 - 2e-32 112.8 14.0 2e-32 112.8 14.0 2.1 2 0 0 2 2 2 1 FAT domain UME PF08064.13 EFA75155.1 - 1.1e-18 67.0 6.3 2.5e-18 65.9 0.1 4.6 5 0 0 5 5 5 1 UME (NUC010) domain FATC PF02260.20 EFA75155.1 - 2e-05 24.3 0.1 5.7e-05 22.8 0.1 1.9 1 0 0 1 1 1 1 FATC domain HSP20 PF00011.21 EFA75156.1 - 7.8e-18 64.5 2.8 3.3e-11 43.2 0.5 2.3 1 1 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA75156.1 - 9.1e-09 34.8 0.0 5e-08 32.4 0.0 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFA75156.1 - 0.0037 18.3 4.0 0.011 16.7 0.3 2.3 1 1 1 2 2 2 1 CS domain FKBP26_C PF18046.1 EFA75156.1 - 0.008 16.2 0.5 0.017 15.2 0.2 1.7 2 0 0 2 2 2 1 FKBP26_C-terminal DUF4962 PF16332.5 EFA75156.1 - 0.04 12.4 2.0 0.05 12.1 2.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) NCD2 PF04905.13 EFA75156.1 - 0.059 13.3 0.2 0.092 12.7 0.2 1.3 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) LRR_6 PF13516.6 EFA75157.1 - 2.9e-14 51.8 31.0 0.00072 19.4 0.0 9.4 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.7 EFA75157.1 - 1.7e-08 34.6 13.5 0.038 14.4 0.3 6.0 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA75157.1 - 5.3e-08 32.3 2.1 2.3 9.1 0.0 7.5 7 1 0 7 7 7 2 Leucine Rich Repeat PH_3 PF14593.6 EFA75157.1 - 6.8e-05 22.9 0.5 0.00019 21.5 0.5 1.7 1 0 0 1 1 1 1 PH domain Carm_PH PF17888.1 EFA75157.1 - 7.5e-05 23.0 0.3 0.00027 21.3 0.3 1.9 1 0 0 1 1 1 1 Carmil pleckstrin homology domain LRR_8 PF13855.6 EFA75157.1 - 0.014 15.2 12.7 0.031 14.0 1.9 5.3 4 2 0 4 4 4 0 Leucine rich repeat Myosin_TH1 PF06017.13 EFA75157.1 - 0.026 14.2 0.5 0.071 12.8 0.5 1.7 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding DUF3808 PF10300.9 EFA75158.1 - 1.6e-33 116.2 3.0 7.6e-33 114.0 0.9 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EFA75158.1 - 2.2e-06 27.3 2.8 0.55 10.5 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFA75158.1 - 0.0071 15.6 0.2 1.3 8.2 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA75158.1 - 0.012 15.8 4.4 10 6.7 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA75158.1 - 0.12 12.7 7.7 1.5 9.2 0.0 4.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA75158.1 - 0.17 11.7 6.6 58 3.7 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA75158.1 - 0.41 11.4 5.4 21 6.0 0.0 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat Ribosomal_S9 PF00380.19 EFA75159.1 - 6.6e-32 110.6 0.1 1.1e-31 109.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF1772 PF08592.11 EFA75160.1 - 0.021 15.1 0.2 8.1 6.8 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Ferric_reduct PF01794.19 EFA75160.1 - 0.27 11.4 6.4 0.063 13.4 2.3 2.1 1 1 0 2 2 2 0 Ferric reductase like transmembrane component DUF202 PF02656.15 EFA75160.1 - 0.48 10.9 2.1 0.9 10.0 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF202) PDR_assoc PF08370.11 EFA75161.1 - 3.3 7.5 8.4 7.8 6.3 1.4 2.8 2 0 0 2 2 2 0 Plant PDR ABC transporter associated Cadherin_C_2 PF16492.5 EFA75161.1 - 4.8 8.0 5.8 21 5.9 5.8 2.1 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal DnaJ_C PF01556.18 EFA75162.1 - 1.2e-35 122.8 0.0 2.1e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFA75162.1 - 3.1e-22 78.5 1.1 6.8e-22 77.4 1.1 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFA75162.1 - 0.002 18.4 1.9 0.0082 16.5 1.9 2.1 1 0 0 1 1 1 1 DnaJ central domain SMI1_KNR4 PF09346.10 EFA75162.1 - 0.37 11.2 2.6 1.4 9.3 1.4 2.5 1 1 1 2 2 2 0 SMI1 / KNR4 family (SUKH-1) DUF1996 PF09362.10 EFA75163.1 - 8.3e-39 134.0 2.7 1.3e-38 133.4 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) YnfE PF17452.2 EFA75164.1 - 0.44 10.9 7.8 0.35 11.2 0.9 3.0 2 0 0 2 2 2 0 Uncharacterized YnfE-like Baculo_E56 PF04639.12 EFA75165.1 - 1.3 8.2 4.6 3.5 6.8 0.0 2.6 3 0 0 3 3 3 0 Baculoviral E56 protein, specific to ODV envelope AAA PF00004.29 EFA75166.1 - 1.1e-11 45.3 0.0 2.4e-11 44.2 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFA75166.1 - 8.9e-09 35.5 0.2 1.5e-05 25.0 0.0 2.3 1 1 0 2 2 2 2 Rad17 P-loop domain AAA_14 PF13173.6 EFA75166.1 - 6e-06 26.3 0.1 1.9e-05 24.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 EFA75166.1 - 2.4e-05 24.1 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFA75166.1 - 7.3e-05 23.2 0.0 0.0013 19.2 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFA75166.1 - 0.00016 22.0 0.1 0.0099 16.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA75166.1 - 0.00019 21.8 0.6 0.029 14.7 0.4 3.1 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 EFA75166.1 - 0.0015 19.1 0.2 0.0087 16.6 0.0 2.4 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EFA75166.1 - 0.0015 18.8 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFA75166.1 - 0.0045 16.4 0.2 0.046 13.1 0.1 2.1 1 1 1 2 2 2 1 KaiC NACHT PF05729.12 EFA75166.1 - 0.0055 16.6 0.7 0.26 11.2 0.4 2.3 1 1 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.12 EFA75166.1 - 0.008 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin IstB_IS21 PF01695.17 EFA75166.1 - 0.0091 15.7 0.0 0.027 14.2 0.0 1.9 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 EFA75166.1 - 0.018 15.2 0.0 0.037 14.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFA75166.1 - 0.018 14.4 0.7 0.027 13.9 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EFA75166.1 - 0.019 15.0 0.1 0.039 14.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EFA75166.1 - 0.02 15.2 0.0 0.078 13.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EFA75166.1 - 0.022 14.7 0.9 0.15 11.9 0.2 2.3 1 1 0 2 2 2 0 NTPase AAA_33 PF13671.6 EFA75166.1 - 0.024 14.8 0.0 0.069 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EFA75166.1 - 0.055 12.5 0.1 0.09 11.8 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.6 EFA75166.1 - 0.071 13.5 0.4 0.31 11.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EFA75166.1 - 0.072 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_7 PF12775.7 EFA75166.1 - 0.12 11.9 1.5 0.22 11.0 0.0 2.1 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFA75166.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SUIM_assoc PF16619.5 EFA75167.1 - 0.0067 16.5 1.6 0.0082 16.2 1.6 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 PspB PF06667.12 EFA75167.1 - 0.096 12.8 1.7 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 Phage shock protein B TMEM154 PF15102.6 EFA75169.1 - 5.3 6.9 8.8 7.2 6.5 8.8 1.2 1 0 0 1 1 1 0 TMEM154 protein family WD40 PF00400.32 EFA75170.1 - 2.3e-10 40.9 0.4 0.001 19.8 0.2 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75170.1 - 0.016 15.5 0.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA75170.1 - 0.25 9.9 1.5 3 6.4 0.0 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Maf1 PF09174.10 EFA75171.1 - 0.078 13.1 0.0 0.078 13.1 0.0 1.1 1 0 0 1 1 1 0 Maf1 regulator WD40 PF00400.32 EFA75172.1 - 9.8e-22 76.9 0.5 2e-05 25.2 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75172.1 - 6.8e-07 29.5 0.1 1.1 9.6 0.1 4.2 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA75172.1 - 1.9e-06 26.8 1.4 0.21 10.2 0.5 3.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EFA75172.1 - 0.00024 20.5 0.0 0.0075 15.6 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 EFA75172.1 - 0.0004 20.3 0.3 0.027 14.4 0.0 2.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A NUP214 PF16755.5 EFA75172.1 - 0.006 15.9 0.0 0.0098 15.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 GDPD_2 PF13653.6 EFA75172.1 - 0.018 15.5 0.0 0.16 12.5 0.0 2.3 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family BBS2_Mid PF14783.6 EFA75172.1 - 0.11 12.5 0.4 25 5.0 0.0 3.4 3 1 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Hydrolase_6 PF13344.6 EFA75173.1 - 2.1e-19 69.5 0.0 3.8e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFA75173.1 - 7.9e-17 61.1 0.0 4e-16 58.8 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 EFA75173.1 - 0.0057 16.8 0.0 0.38 10.8 0.0 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase SLH PF00395.20 EFA75173.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 S-layer homology domain CAP PF00188.26 EFA75174.1 - 6.3e-16 59.4 0.4 6.3e-16 59.4 0.4 2.2 3 0 0 3 3 3 1 Cysteine-rich secretory protein family B_lectin PF01453.24 EFA75174.1 - 4.8e-07 30.3 0.9 8e-05 23.1 0.0 2.5 1 1 1 2 2 2 2 D-mannose binding lectin Aconitase PF00330.20 EFA75175.1 - 1.8e-154 515.2 0.0 2.2e-154 514.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFA75175.1 - 2.7e-45 153.9 0.0 5e-45 153.0 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain FNIP PF05725.12 EFA75176.1 - 2.6e-22 78.7 41.8 3.4e-05 23.9 0.3 10.1 5 3 7 12 12 12 10 FNIP Repeat LRR_5 PF13306.6 EFA75176.1 - 0.045 13.7 0.5 0.045 13.7 0.5 4.5 1 1 4 5 5 5 0 BspA type Leucine rich repeat region (6 copies) FNIP PF05725.12 EFA75177.1 - 0.00033 20.8 0.8 0.16 12.2 0.0 2.5 1 1 2 3 3 3 3 FNIP Repeat MTHFR PF02219.17 EFA75178.1 - 1.5e-119 398.6 0.0 2.2e-119 398.1 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PHF5 PF03660.14 EFA75179.1 - 8.9e-51 170.5 13.5 1e-50 170.3 13.5 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EFA75179.1 - 0.015 13.2 6.9 0.015 13.2 6.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 CbiC PF02570.15 EFA75179.1 - 0.021 14.5 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 Precorrin-8X methylmutase DZR PF12773.7 EFA75179.1 - 1.2 9.3 17.0 2.2 8.4 2.6 3.1 1 1 1 2 2 2 0 Double zinc ribbon DUF2757 PF10955.8 EFA75179.1 - 7.6 6.9 11.7 1 9.7 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) N_BRCA1_IG PF16158.5 EFA75180.1 - 1.1e-09 38.9 1.4 4.7e-09 36.9 0.0 2.8 3 0 0 3 3 3 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EFA75180.1 - 1.7e-05 24.5 7.5 6.8e-05 22.6 7.5 2.1 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 EFA75180.1 - 0.005 16.7 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 PB1 domain Cellulase PF00150.18 EFA75181.1 - 7.1e-30 104.4 0.2 1.3e-29 103.5 0.2 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 EFA75181.1 - 3.1e-14 53.3 0.2 7e-14 52.1 0.2 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_1 PF00232.18 EFA75181.1 - 2.5e-05 22.9 0.1 4e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 GFA PF04828.14 EFA75182.1 - 0.00011 22.4 1.7 0.00018 21.8 1.7 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme RhoGAP PF00620.27 EFA75183.1 - 9.3e-42 142.4 0.7 9.3e-42 142.4 0.7 5.4 4 2 2 7 7 7 1 RhoGAP domain ATG27 PF09451.10 EFA75184.1 - 6.2e-35 121.3 0.0 8.5e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFA75184.1 - 2.2e-11 43.4 0.0 2.5e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 EFA75184.1 - 9.4e-07 29.0 2.3 3.3e-06 27.3 1.3 1.9 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat WH2 PF02205.20 EFA75185.1 - 0.00029 20.6 0.0 0.0023 17.7 0.0 2.2 2 0 0 2 2 2 1 WH2 motif DUF1993 PF09351.10 EFA75185.1 - 0.12 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) LIM PF00412.22 EFA75186.1 - 3.7e-09 36.7 12.8 5.2e-09 36.2 12.8 1.2 1 0 0 1 1 1 1 LIM domain Meiotic_rec114 PF03525.14 EFA75186.1 - 0.00011 21.3 0.1 3.4 6.5 0.0 3.1 1 1 2 3 3 3 3 Meiotic recombination protein rec114 Ras PF00071.22 EFA75187.1 - 0.066 12.8 0.0 0.075 12.6 0.0 1.0 1 0 0 1 1 1 0 Ras family UFD1 PF03152.14 EFA75188.1 - 2e-70 235.7 0.2 2.9e-70 235.2 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Sod_Fe_C PF02777.18 EFA75189.1 - 1.9e-36 124.3 0.9 3.3e-36 123.5 0.1 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFA75189.1 - 1.3e-30 105.7 0.1 2.7e-30 104.7 0.1 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Ribosomal_L11_N PF03946.14 EFA75189.1 - 0.018 14.9 0.2 0.039 13.8 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain DPBB_1 PF03330.18 EFA75190.1 - 4e-16 59.1 0.1 4e-16 59.1 0.1 2.2 2 1 0 2 2 2 1 Lytic transglycolase LysM PF01476.20 EFA75190.1 - 7.6e-05 22.7 0.0 0.58 10.3 0.0 2.6 2 0 0 2 2 2 2 LysM domain Gp138_N PF18352.1 EFA75190.1 - 0.14 12.2 0.8 31 4.7 0.0 3.0 3 0 0 3 3 3 0 Phage protein Gp138 N-terminal domain Antig_Caf1 PF09255.10 EFA75190.1 - 0.3 11.2 2.8 2.5 8.2 0.0 2.4 1 1 1 2 2 2 0 Caf1 Capsule antigen AA_permease_2 PF13520.6 EFA75191.1 - 7.7e-48 163.4 46.0 1e-47 163.0 45.6 1.4 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 EFA75191.1 - 3.8e-07 29.1 17.5 3.8e-07 29.1 17.5 2.7 2 1 0 2 2 2 1 Amino acid permease SNAP PF14938.6 EFA75192.1 - 3.9e-22 79.0 13.7 5.1e-22 78.6 13.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFA75192.1 - 0.00025 21.2 4.4 0.004 17.4 2.8 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75192.1 - 1 9.6 7.1 9.7 6.6 0.4 4.4 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA75192.1 - 1.5 9.6 6.2 53 4.8 0.1 4.7 3 1 0 4 4 4 0 Tetratricopeptide repeat GTP_EFTU PF00009.27 EFA75193.1 - 1.9e-29 102.6 0.5 5.1e-29 101.2 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA75193.1 - 4.6e-08 33.1 0.1 1.1e-07 31.9 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFA75193.1 - 7.3e-06 26.3 0.3 2.8e-05 24.4 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 SRPRB PF09439.10 EFA75193.1 - 7.9e-05 22.2 1.0 0.00072 19.0 1.0 2.2 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit DcpS PF05652.12 EFA75193.1 - 0.0056 17.5 0.5 4.2 8.2 0.0 2.6 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme (DcpS) N-terminal PduV-EutP PF10662.9 EFA75193.1 - 0.012 15.3 3.1 1.2 8.9 0.1 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 EFA75193.1 - 0.15 12.1 1.9 2.2 8.4 1.9 2.9 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RIBIOP_C PF04950.12 EFA75193.1 - 0.19 11.2 4.8 7.1 6.0 4.7 2.4 1 1 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal LZ3wCH PF18517.1 EFA75194.1 - 8.9e-11 41.7 3.0 8.9e-11 41.7 3.0 1.9 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Ribosomal_S2 PF00318.20 EFA75194.1 - 0.011 14.9 2.3 0.015 14.5 2.3 1.3 1 1 0 1 1 1 0 Ribosomal protein S2 QueH PF02677.14 EFA75194.1 - 0.11 12.6 1.8 0.16 12.1 0.2 1.8 1 1 1 2 2 2 0 Epoxyqueuosine reductase QueH CDK5_activator PF03261.15 EFA75194.1 - 0.25 10.8 8.6 0.28 10.7 8.6 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein CLU PF13236.6 EFA75195.1 - 1.4e-59 201.6 0.0 2.9e-59 200.6 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA75195.1 - 1.3e-09 38.4 1.4 2.4e-08 34.2 0.0 2.4 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 DUF3080 PF11279.8 EFA75195.1 - 0.039 13.2 7.4 0.069 12.4 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) PIH1 PF08190.12 EFA75196.1 - 0.11 11.9 0.1 0.24 10.8 0.0 1.5 2 0 0 2 2 2 0 PIH1 N-terminal domain CLU PF13236.6 EFA75197.1 - 4.9e-56 190.0 0.0 1e-55 189.0 0.0 1.6 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA75197.1 - 2.4e-07 31.0 0.1 2.4e-07 31.0 0.1 2.7 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 LRR_4 PF12799.7 EFA75197.1 - 0.012 16.0 28.5 43 4.7 0.0 9.5 5 3 6 11 11 11 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA75197.1 - 0.46 11.2 7.5 5.9 7.9 0.4 6.0 4 2 0 4 4 4 0 Leucine Rich Repeat MFS_1 PF07690.16 EFA75198.1 - 1.2e-06 27.8 40.5 0.0084 15.1 18.4 3.7 1 1 2 3 3 3 3 Major Facilitator Superfamily ABC2_membrane_2 PF12679.7 EFA75198.1 - 0.14 11.4 6.6 2.8 7.1 0.7 2.8 3 0 0 3 3 3 0 ABC-2 family transporter protein 7tm_2 PF00002.24 EFA75199.1 - 1.3e-06 27.9 10.7 3e-06 26.7 10.7 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Frizzled PF01534.17 EFA75199.1 - 4.7e-05 22.6 13.1 7.8e-05 21.9 13.1 1.4 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region MOSC PF03473.17 EFA75200.1 - 0.00019 21.4 0.0 0.00034 20.6 0.0 1.4 1 0 0 1 1 1 1 MOSC domain DUF829 PF05705.14 EFA75201.1 - 1.5e-57 195.2 0.5 1.2e-20 74.5 0.0 3.5 2 1 1 3 3 3 3 Eukaryotic protein of unknown function (DUF829) DNA_alkylation PF08713.11 EFA75201.1 - 2.8e-48 164.5 0.4 4.4e-48 163.8 0.4 1.2 1 0 0 1 1 1 1 DNA alkylation repair enzyme PP2C PF00481.21 EFA75202.1 - 1.3e-61 208.5 0.0 2.2e-61 207.7 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EFA75202.1 - 3.1e-46 154.9 72.0 3.5e-09 36.3 9.0 9.2 5 2 6 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 EFA75202.1 - 1e-37 127.5 74.7 1.5e-06 28.4 4.9 11.0 8 2 3 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFA75202.1 - 9.4e-10 38.3 26.6 0.00023 20.7 1.7 5.6 4 1 2 6 6 6 3 Leucine-rich repeat PP2C_2 PF13672.6 EFA75202.1 - 1e-05 25.3 0.0 1.7e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_6 PF13516.6 EFA75202.1 - 0.0022 17.9 65.5 0.3 11.2 0.2 14.2 15 0 0 15 15 15 3 Leucine Rich repeat RsmF_methylt_CI PF17126.5 EFA75202.1 - 0.23 11.5 0.6 13 5.9 0.0 3.5 3 1 1 4 4 4 0 RsmF rRNA methyltransferase first C-terminal domain LRR_1 PF00560.33 EFA75202.1 - 0.67 10.7 73.7 3.7 8.5 0.9 16.7 16 1 1 17 17 17 0 Leucine Rich Repeat RSN1_7TM PF02714.15 EFA75203.1 - 0.00083 18.7 30.7 0.0026 17.1 30.7 1.9 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EFA75203.1 - 0.062 13.5 4.8 1.7 8.9 2.8 2.8 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Glyco_hydro_25 PF01183.20 EFA75204.1 - 1.6e-12 47.9 0.0 1.9e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Cbl_N2 PF02761.14 EFA75205.1 - 0.23 12.2 4.2 0.7 10.6 0.5 3.0 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain SSP160 PF06933.11 EFA75206.1 - 0.014 13.6 14.1 0.015 13.5 14.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AJAP1_PANP_C PF15298.6 EFA75206.1 - 0.017 15.4 10.9 0.019 15.2 10.9 1.1 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Dicty_REP PF05086.12 EFA75206.1 - 0.023 12.7 10.5 0.024 12.6 10.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.13 EFA75206.1 - 0.1 10.9 2.0 0.12 10.7 2.0 1.0 1 0 0 1 1 1 0 Menin NST1 PF13945.6 EFA75206.1 - 0.11 12.6 5.3 0.13 12.4 5.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Mucin PF01456.17 EFA75206.1 - 0.21 11.6 23.4 0.25 11.3 23.4 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 EFA75206.1 - 0.34 9.0 10.2 0.38 8.8 10.2 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MGC-24 PF05283.11 EFA75206.1 - 0.77 10.2 10.6 0.96 9.9 10.6 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TMEM154 PF15102.6 EFA75206.1 - 1 9.3 7.2 1.2 9.1 7.2 1.2 1 0 0 1 1 1 0 TMEM154 protein family RNA_pol_3_Rpc31 PF11705.8 EFA75208.1 - 0.00055 20.3 15.9 0.00094 19.5 15.9 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 PPP4R2 PF09184.11 EFA75208.1 - 0.0049 16.5 14.2 0.0049 16.5 14.2 1.9 2 0 0 2 2 2 1 PPP4R2 SDA1 PF05285.12 EFA75208.1 - 0.47 9.8 17.3 0.63 9.4 17.3 1.2 1 0 0 1 1 1 0 SDA1 TFIIA PF03153.13 EFA75208.1 - 1.5 8.8 18.8 2.1 8.3 18.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Astro_capsid_p PF12226.8 EFA75208.1 - 2.2 7.3 14.8 3.3 6.8 14.8 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sigma70_ner PF04546.13 EFA75208.1 - 2.8 7.8 15.2 6.6 6.6 15.2 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region CobT PF06213.12 EFA75208.1 - 2.8 7.2 20.5 4.5 6.6 20.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT IucA_IucC PF04183.12 EFA75210.1 - 1.2e-51 175.6 0.0 1.7e-51 175.1 0.0 1.3 1 0 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 EFA75210.1 - 0.066 13.6 0.1 0.91 9.9 0.0 2.7 2 1 0 2 2 2 0 Ferric iron reductase FhuF-like transporter DUF1803 PF08820.10 EFA75210.1 - 0.13 12.3 2.9 0.28 11.2 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) IucA_IucC PF04183.12 EFA75211.1 - 3.7e-51 174.0 0.0 5.3e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 EFA75211.1 - 0.001 19.5 0.1 0.019 15.3 0.1 2.4 1 1 0 1 1 1 1 Ferric iron reductase FhuF-like transporter PAC1 PF16094.5 EFA75212.1 - 2.2e-10 40.2 0.6 2.3e-10 40.1 0.6 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 PAC2 PF09754.9 EFA75212.1 - 0.038 14.0 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 PAC2 family RasGEF PF00617.19 EFA75213.1 - 7.2e-55 185.9 2.5 7.2e-55 185.9 2.5 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFA75213.1 - 0.0031 17.7 0.1 0.0031 17.7 0.1 3.8 3 1 0 3 3 3 1 RasGEF N-terminal motif MADF_DNA_bdg PF10545.9 EFA75213.1 - 0.024 14.9 0.2 0.076 13.3 0.2 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like AAA_16 PF13191.6 EFA75214.1 - 5.8e-12 46.3 0.0 1.7e-11 44.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain RACo_linker PF17650.1 EFA75214.1 - 0.15 11.9 0.0 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 RACo linker region THEG4 PF15834.5 EFA75214.1 - 3.7 7.5 7.1 1.5 8.8 0.1 3.0 2 0 0 2 2 2 0 Testis highly expressed protein 4 Arf PF00025.21 EFA75215.1 - 8.1e-48 162.2 2.7 1.1e-22 80.3 0.3 3.0 1 1 2 3 3 3 3 ADP-ribosylation factor family SRPRB PF09439.10 EFA75215.1 - 6.5e-06 25.7 0.7 0.009 15.5 0.1 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFA75215.1 - 0.00044 19.5 6.1 0.11 11.7 6.1 2.8 1 1 0 1 1 1 1 G-protein alpha subunit TFIIE_beta PF02186.15 EFA75215.1 - 0.0061 16.8 0.1 0.77 10.1 0.0 2.6 2 0 0 2 2 2 1 TFIIE beta subunit core domain Gtr1_RagA PF04670.12 EFA75215.1 - 0.0065 15.8 0.9 1.5 8.2 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA75215.1 - 0.014 15.6 0.6 1.8 8.8 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase COesterase PF00135.28 EFA75216.1 - 3e-99 333.2 2.0 3.9e-99 332.9 2.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA75216.1 - 1e-07 32.1 0.3 3.1e-07 30.5 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA75216.1 - 0.0065 16.0 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EFA75216.1 - 0.082 12.5 0.8 0.27 10.8 0.8 1.7 1 1 0 1 1 1 0 Putative esterase Endopep_inhib PF16800.5 EFA75216.1 - 0.15 12.0 0.3 0.97 9.4 0.2 2.1 2 0 0 2 2 2 0 IseA DL-endopeptidase inhibitor Sec63 PF02889.16 EFA75217.1 - 7.1e-26 90.9 6.7 4.5e-16 58.8 5.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.31 EFA75217.1 - 1.3e-17 63.6 0.0 5e-17 61.8 0.0 2.1 1 0 0 1 1 1 1 DnaJ domain ArgoMid PF16487.5 EFA75217.1 - 0.06 13.6 0.3 13 6.1 0.0 2.7 2 0 0 2 2 2 0 Mid domain of argonaute Presenilin PF01080.17 EFA75217.1 - 0.082 11.7 14.1 0.15 10.8 14.1 1.5 1 0 0 1 1 1 0 Presenilin MDM1 PF15501.6 EFA75217.1 - 0.14 11.3 31.8 0.011 14.9 24.8 2.0 2 0 0 2 2 2 0 Nuclear protein MDM1 Hid1 PF12722.7 EFA75217.1 - 2.2 6.3 14.3 3.4 5.7 14.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 EFA75217.1 - 3.2 7.0 41.3 0.0089 15.4 31.5 1.7 2 0 0 2 2 2 0 BUD22 Ndc1_Nup PF09531.10 EFA75217.1 - 4.5 5.8 8.9 10 4.7 8.9 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4407 PF14362.6 EFA75217.1 - 6.1 6.1 17.9 13 5.0 17.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Frataxin_Cyay PF01491.16 EFA75218.1 - 7.9e-33 112.8 0.0 1.4e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Frataxin-like domain Apis_Csd PF11671.8 EFA75218.1 - 0.032 14.3 5.2 0.05 13.6 5.2 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein GRASP55_65 PF04495.14 EFA75219.1 - 3.4e-65 218.5 0.0 6.3e-47 159.4 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 EFA75219.1 - 0.00022 21.5 0.0 0.1 12.9 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 EFA75219.1 - 0.16 11.8 0.0 7 6.6 0.0 2.6 2 0 0 2 2 2 0 PDZ domain SURF6 PF04935.12 EFA75219.1 - 1 9.1 5.9 1.5 8.5 5.9 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 HSA PF07529.13 EFA75221.1 - 3 8.2 7.3 1.9 8.9 0.1 4.1 4 0 0 4 4 4 0 HSA GHMP_kinases_N PF00288.26 EFA75222.1 - 1.2e-09 38.2 0.1 3e-09 37.0 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain DUF4277 PF14104.6 EFA75222.1 - 0.034 14.5 0.3 0.14 12.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4277) MRP-S25 PF13741.6 EFA75223.1 - 0.006 16.2 6.7 0.012 15.2 6.7 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 EVI2A PF05399.11 EFA75223.1 - 0.86 9.1 23.5 1.4 8.5 23.5 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF4666 PF15697.5 EFA75223.1 - 2.6 8.8 6.9 1.5 9.5 2.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4666) SOG2 PF10428.9 EFA75223.1 - 2.9 7.0 24.2 4 6.5 24.2 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 EFA75223.1 - 7.7 6.3 19.0 9.8 6.0 19.0 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 EFA75223.1 - 8.7 4.8 15.2 10 4.5 15.2 1.0 1 0 0 1 1 1 0 Macoilin family DUF1712 PF08217.11 EFA75224.1 - 1.2e-59 202.4 17.2 2.6e-50 171.6 13.0 3.0 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1712) Ist1 PF03398.14 EFA75225.1 - 2.4e-53 180.4 4.5 3.1e-53 180.1 4.5 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Gelsolin PF00626.22 EFA75226.1 - 5e-43 144.9 0.2 1.4e-14 53.7 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat ABC_tran PF00005.27 EFA75227.1 - 3.1e-56 189.7 2.7 1.1e-26 94.0 0.0 4.2 4 1 0 4 4 4 2 ABC transporter AAA_21 PF13304.6 EFA75227.1 - 1.3e-15 58.0 14.3 8.1e-07 29.1 0.8 4.7 3 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 EFA75227.1 - 1.6e-11 44.0 14.0 3.7e-10 39.7 1.2 3.4 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EFA75227.1 - 9e-09 35.1 5.1 0.00046 19.7 0.6 4.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA75227.1 - 2.2e-07 30.5 2.5 0.0025 17.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.29 EFA75227.1 - 2e-05 25.0 0.0 0.02 15.3 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EFA75227.1 - 2.8e-05 24.2 0.0 0.29 11.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 EFA75227.1 - 3e-05 24.2 0.6 0.12 12.5 0.0 3.2 3 1 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EFA75227.1 - 0.00017 20.9 0.2 0.43 9.7 0.0 2.7 2 1 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.6 EFA75227.1 - 0.00018 22.1 6.1 0.18 12.3 0.2 4.0 4 1 0 4 4 3 2 AAA domain AAA_23 PF13476.6 EFA75227.1 - 0.00026 21.5 0.1 0.00026 21.5 0.1 5.0 4 1 1 5 5 5 2 AAA domain RsgA_GTPase PF03193.16 EFA75227.1 - 0.00044 20.2 4.1 0.44 10.4 0.0 3.3 2 1 1 3 3 3 2 RsgA GTPase RNA_helicase PF00910.22 EFA75227.1 - 0.00051 20.4 0.0 1.8 9.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase SbcCD_C PF13558.6 EFA75227.1 - 0.00059 20.0 5.7 5.7 7.3 0.0 5.0 3 2 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EFA75227.1 - 0.00059 20.3 1.5 0.11 12.9 0.0 3.3 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFA75227.1 - 0.0011 19.2 1.9 1.1 9.6 0.2 3.4 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFA75227.1 - 0.0012 18.9 0.3 3 7.9 0.1 3.7 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EFA75227.1 - 0.0022 18.3 2.5 1.9 8.7 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_24 PF13479.6 EFA75227.1 - 0.0033 17.2 0.6 1.7 8.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.23 EFA75227.1 - 0.0069 16.5 0.1 0.089 12.8 0.0 2.6 2 1 0 2 2 2 1 Dynamin family ATPase_2 PF01637.18 EFA75227.1 - 0.013 15.4 0.7 5.3 6.9 0.0 2.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Tiam_CC_Ex PF18385.1 EFA75227.1 - 0.015 15.7 0.1 0.045 14.2 0.1 1.8 1 0 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain AAA_30 PF13604.6 EFA75227.1 - 0.019 14.7 0.2 3.9 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EFA75227.1 - 0.022 13.7 0.1 2.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_5 PF07728.14 EFA75227.1 - 0.023 14.7 0.1 6.4 6.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 EFA75227.1 - 0.027 14.7 2.2 3.8 7.7 0.0 3.5 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 EFA75227.1 - 0.038 13.9 3.5 4.8 7.1 0.1 3.0 3 0 0 3 3 3 0 NACHT domain MukB PF04310.12 EFA75227.1 - 0.057 13.2 2.7 1 9.1 0.0 3.0 3 0 0 3 3 3 0 MukB N-terminal AAA_25 PF13481.6 EFA75227.1 - 0.073 12.6 0.1 34 3.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 EFA75227.1 - 0.097 12.4 0.1 5.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 EFA75227.1 - 0.17 11.8 0.6 7.6 6.4 0.1 3.0 2 1 0 2 2 2 0 NTPase DUF87 PF01935.17 EFA75227.1 - 0.21 11.7 10.2 0.39 10.8 0.2 4.3 5 0 0 5 5 5 0 Helicase HerA, central domain Cytidylate_kin PF02224.18 EFA75227.1 - 0.33 10.6 8.7 2 8.1 0.0 4.0 4 0 0 4 4 4 0 Cytidylate kinase RNA_pol_Rpb5_C PF01191.19 EFA75227.1 - 0.36 10.7 2.0 6.3 6.7 0.8 3.2 4 0 0 4 4 3 0 RNA polymerase Rpb5, C-terminal domain AAA_13 PF13166.6 EFA75227.1 - 0.5 9.0 13.0 3.3 6.2 0.0 4.1 3 1 0 5 5 4 0 AAA domain PA14 PF07691.12 EFA75228.1 - 1.9e-08 34.2 0.0 3.8e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Dicty_CTDC PF00526.18 EFA75228.1 - 8e-08 32.0 43.8 3.2e-05 23.7 9.2 14.6 14 4 0 14 14 14 7 Dictyostelium (slime mold) repeat PA14 PF07691.12 EFA75229.1 - 2e-10 40.7 0.1 3.3e-10 40.0 0.1 1.3 1 0 0 1 1 1 1 PA14 domain Dicty_CTDC PF00526.18 EFA75229.1 - 1.6e-07 31.1 44.0 2.6e-05 24.0 7.5 14.7 15 2 0 15 15 15 7 Dictyostelium (slime mold) repeat Integrin_b_cyt PF08725.11 EFA75229.1 - 2.5 7.8 4.7 6 6.6 1.5 2.6 2 1 0 2 2 2 0 Integrin beta cytoplasmic domain Cyt-b5 PF00173.28 EFA75230.1 - 5.5e-17 61.7 0.0 1.3e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 EFA75230.1 - 2.9e-16 60.1 28.5 1.3e-13 51.4 9.7 3.7 3 1 0 3 3 3 3 Fatty acid desaturase WXG100 PF06013.12 EFA75230.1 - 0.13 12.5 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Proteins of 100 residues with WXG AA_kinase PF00696.28 EFA75231.1 - 8.1e-45 153.3 0.0 1.2e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family MRG PF05712.13 EFA75234.1 - 1.5e-15 57.1 1.4 4.5e-09 35.9 0.2 2.3 1 1 1 2 2 2 2 MRG tRNA-synt_1c PF00749.21 EFA75236.1 - 6.4e-104 347.2 0.0 8.7e-104 346.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Ank_4 PF13637.6 EFA75237.1 - 4.2e-20 71.8 1.1 4.1e-07 30.4 0.0 4.2 2 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75237.1 - 6.4e-20 71.0 2.3 5e-06 26.7 0.1 4.1 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75237.1 - 1.2e-17 64.2 1.0 8.8e-07 29.4 0.1 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75237.1 - 6e-11 41.6 0.7 0.00066 19.9 0.1 5.0 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 EFA75237.1 - 2.2e-09 37.3 1.9 0.00048 20.4 0.1 4.7 4 1 0 4 4 4 2 Ankyrin repeat Asparaginase PF00710.20 EFA75238.1 - 1.2e-65 220.7 0.0 4.8e-65 218.7 0.0 2.1 3 0 0 3 3 3 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFA75238.1 - 4.2e-31 107.5 0.9 8.9e-31 106.5 0.1 2.0 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain CBM64 PF18666.1 EFA75239.1 - 0.28 11.3 2.4 3.3 7.8 0.1 2.6 2 1 0 2 2 2 0 Carbohydrate-binding module 64 LPAM_1 PF08139.12 EFA75239.1 - 0.29 11.7 4.7 6.5 7.4 1.1 2.9 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site Ctr PF04145.15 EFA75240.1 - 0.11 13.1 2.2 3.6 8.2 0.1 3.1 3 0 0 3 3 3 0 Ctr copper transporter family CTNNBL PF08216.11 EFA75242.1 - 2.6e-28 98.3 15.9 7e-27 93.6 5.5 4.0 2 2 1 3 3 3 1 Catenin-beta-like, Arm-motif containing nuclear Myb_DNA-binding PF00249.31 EFA75243.1 - 3.5e-31 107.1 11.9 7.5e-14 51.7 0.8 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA75243.1 - 1.7e-24 85.8 14.0 8.7e-14 51.5 0.2 4.0 3 1 1 4 4 4 3 Myb-like DNA-binding domain TFIIA PF03153.13 EFA75243.1 - 8.2e-05 22.8 17.4 0.00012 22.3 17.4 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SLIDE PF09111.10 EFA75243.1 - 0.00072 19.6 4.2 0.61 10.1 0.0 3.8 3 0 0 3 3 3 2 SLIDE SANT_DAMP1_like PF16282.5 EFA75243.1 - 0.0012 19.0 0.3 0.58 10.4 0.0 3.2 2 1 0 2 2 2 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_4 PF13837.6 EFA75243.1 - 0.048 14.0 0.6 0.048 14.0 0.6 3.8 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain DUF4757 PF15949.5 EFA75243.1 - 2.1 8.8 12.0 6 7.3 12.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4757) CCM2_C PF16545.5 EFA75243.1 - 6.2 7.4 8.3 0.12 13.0 0.5 2.2 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology CLTH PF10607.9 EFA75244.1 - 4.8e-32 110.9 0.1 7.2e-32 110.3 0.1 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain FGGY_N PF00370.21 EFA75245.1 - 2.1e-69 233.8 1.2 3.8e-68 229.7 1.2 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EFA75245.1 - 1.2e-66 224.2 0.4 7.7e-66 221.6 0.1 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain tRNA-synt_1b PF00579.25 EFA75246.1 - 1.4e-69 234.7 0.0 1.9e-69 234.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Acetyltransf_6 PF13480.7 EFA75246.1 - 0.05 13.8 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain OTOS PF15182.6 EFA75246.1 - 0.096 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Otospiralin S4 PF01479.25 EFA75246.1 - 0.16 11.7 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 S4 domain Pkinase PF00069.25 EFA75247.1 - 1.8e-45 155.3 0.5 2.3e-34 119.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75247.1 - 2.6e-28 99.0 0.0 5.2e-28 98.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Met_10 PF02475.16 EFA75248.1 - 8.1e-50 169.3 0.1 1.3e-48 165.4 0.1 2.2 1 1 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 EFA75248.1 - 9.1e-06 25.3 0.0 1.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EFA75248.1 - 0.00033 21.3 0.0 0.00098 19.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFA75248.1 - 0.00048 19.7 0.0 0.0009 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain TRM PF02005.16 EFA75248.1 - 0.00071 18.8 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase tRNA_U5-meth_tr PF05958.11 EFA75248.1 - 0.021 13.8 0.2 0.069 12.1 0.0 1.8 2 0 0 2 2 2 0 tRNA (Uracil-5-)-methyltransferase Methyltr_RsmB-F PF01189.17 EFA75248.1 - 0.048 13.3 0.0 0.097 12.3 0.0 1.5 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EFA75248.1 - 0.068 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain LRR_6 PF13516.6 EFA75249.1 - 3.6e-20 70.3 67.9 0.00061 19.6 0.3 16.0 16 0 0 16 16 16 10 Leucine Rich repeat LRR_1 PF00560.33 EFA75249.1 - 0.018 15.5 40.9 21 6.2 0.0 14.4 15 1 0 15 15 15 0 Leucine Rich Repeat ACP_PD PF04336.12 EFA75249.1 - 0.023 15.1 0.1 0.064 13.7 0.1 1.7 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase MM_CoA_mutase PF01642.22 EFA75250.1 - 1.2e-239 796.2 0.3 1.4e-239 795.9 0.3 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 EFA75250.1 - 9.4e-15 54.7 0.4 1.9e-14 53.8 0.4 1.5 1 0 0 1 1 1 1 B12 binding domain PhnI PF05861.12 EFA75250.1 - 0.026 13.4 0.0 0.055 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnI) Pkinase PF00069.25 EFA75251.1 - 4e-77 259.1 0.6 8e-77 258.1 0.6 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75251.1 - 7.7e-39 133.5 0.0 1.3e-38 132.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA75251.1 - 9.9e-09 34.9 0.0 3.3e-08 33.2 0.0 1.9 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFA75251.1 - 0.0035 16.7 0.0 0.008 15.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFA75251.1 - 0.025 13.4 0.2 0.025 13.4 0.2 1.9 2 0 0 2 2 2 0 Fungal protein kinase zf-CCCH PF00642.24 EFA75252.1 - 2e-06 27.5 1.1 4.9e-06 26.3 1.1 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA75252.1 - 2.2e-06 27.5 4.6 4.4e-06 26.6 4.6 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFA75252.1 - 6.8e-06 25.7 1.2 6.8e-06 25.7 1.2 2.0 2 0 0 2 2 2 1 CCCH-type zinc finger HGTP_anticodon PF03129.20 EFA75252.1 - 0.0038 17.3 0.2 0.01 16.0 0.2 1.7 1 0 0 1 1 1 1 Anticodon binding domain Torus PF16131.5 EFA75252.1 - 0.0062 17.2 0.8 0.0062 17.2 0.8 4.2 4 0 0 4 4 4 1 Torus domain zf-C6H2 PF15801.5 EFA75252.1 - 0.0091 16.3 7.7 0.02 15.2 7.7 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-RanBP PF00641.18 EFA75252.1 - 0.059 12.7 3.3 0.22 10.9 3.3 2.1 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others UPF0730 PF15827.5 EFA75253.1 - 0.0041 16.8 0.9 0.022 14.5 0.0 2.4 2 0 0 2 2 2 1 UPF0730 unknown protein family TGF_beta_GS PF08515.12 EFA75253.1 - 0.073 12.6 1.1 0.15 11.5 1.1 1.5 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Peptidase_A22B PF04258.13 EFA75254.1 - 1.3e-38 133.2 15.1 1.9e-38 132.6 15.1 1.2 1 0 0 1 1 1 1 Signal peptide peptidase DUF1056 PF06341.11 EFA75254.1 - 1.3 9.4 0.0 1.3 9.4 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1056) DUF2229 PF09989.9 EFA75255.1 - 0.51 10.0 4.9 1.1 8.9 4.9 1.5 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) I_LWEQ PF01608.17 EFA75256.1 - 1.4e-46 158.5 35.6 1.7e-44 151.8 9.1 4.5 3 1 1 4 4 4 3 I/LWEQ domain ANTH PF07651.16 EFA75256.1 - 1e-45 155.9 0.3 1e-45 155.9 0.3 2.4 2 1 0 2 2 2 1 ANTH domain ENTH PF01417.20 EFA75256.1 - 1.9e-07 31.2 0.0 6.9e-07 29.3 0.0 2.0 1 0 0 1 1 1 1 ENTH domain FAM184 PF15665.5 EFA75256.1 - 0.0053 16.6 8.5 0.0053 16.6 8.5 2.3 2 1 0 2 2 2 1 Family with sequence similarity 184, A and B MotA_ExbB PF01618.16 EFA75256.1 - 0.019 14.7 0.9 1.8 8.3 0.3 3.5 3 0 0 3 3 3 0 MotA/TolQ/ExbB proton channel family Pox_A_type_inc PF04508.12 EFA75256.1 - 0.022 14.6 4.3 0.034 14.0 1.1 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Spc29 PF17082.5 EFA75256.1 - 0.68 9.7 8.8 0.051 13.4 2.9 2.1 2 0 0 2 2 2 0 Spindle Pole Component 29 RPW8 PF05659.11 EFA75256.1 - 0.88 9.3 6.0 2.2 8.0 2.2 3.3 2 1 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 UPF0242 PF06785.11 EFA75256.1 - 8 6.5 13.1 1.6 8.8 8.6 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cortex-I_coil PF09304.10 EFA75257.1 - 3.2e-48 162.4 22.5 3.2e-48 162.4 22.5 3.1 4 0 0 4 4 4 1 Cortexillin I, coiled coil CH PF00307.31 EFA75257.1 - 1.5e-42 144.2 0.2 1.2e-19 70.5 0.0 3.7 3 0 0 3 3 3 2 Calponin homology (CH) domain DUF1664 PF07889.12 EFA75257.1 - 0.28 11.2 5.0 1 9.4 4.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HPP PF04982.13 EFA75258.1 - 0.05 13.8 0.6 0.05 13.8 0.6 1.7 2 0 0 2 2 2 0 HPP family CTP_transf_1 PF01148.20 EFA75258.1 - 0.32 10.7 11.6 0.6 9.8 11.6 1.5 1 1 0 1 1 1 0 Cytidylyltransferase family WD40 PF00400.32 EFA75259.1 - 6.5e-21 74.3 1.9 0.0057 17.5 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75259.1 - 1.2e-17 64.0 0.1 1.8e-07 31.4 0.1 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA75259.1 - 1e-05 24.4 1.3 0.18 10.4 0.0 3.3 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EFA75259.1 - 9.3e-05 21.9 0.2 0.45 9.8 0.1 3.2 4 0 0 4 4 4 2 WD40-like domain Coatomer_WDAD PF04053.14 EFA75259.1 - 0.00019 20.6 1.0 0.019 14.0 0.1 2.4 1 1 2 3 3 3 2 Coatomer WD associated region Ge1_WD40 PF16529.5 EFA75259.1 - 0.0058 15.6 0.0 0.12 11.3 0.0 2.9 2 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EFA75259.1 - 0.012 13.9 0.2 0.021 13.2 0.2 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Baculo_FP PF03258.14 EFA75259.1 - 0.079 13.1 0.0 0.2 11.8 0.0 1.6 2 0 0 2 2 2 0 Baculovirus FP protein PQQ_2 PF13360.6 EFA75259.1 - 0.086 12.4 0.1 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 PQQ-like domain WD40 PF00400.32 EFA75260.1 - 9.2e-21 73.8 1.4 0.012 16.4 0.0 6.4 6 1 0 7 7 5 5 WD domain, G-beta repeat PPR_2 PF13041.6 EFA75260.1 - 4.6e-19 68.4 1.3 3e-11 43.3 0.1 3.6 2 1 1 3 3 3 3 PPR repeat family ANAPC4_WD40 PF12894.7 EFA75260.1 - 1.9e-16 60.1 1.2 1.2e-07 31.9 0.0 5.9 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PPR_3 PF13812.6 EFA75260.1 - 4.8e-10 39.4 0.6 6.1e-06 26.2 0.0 2.5 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 EFA75260.1 - 9.7e-08 31.8 1.0 0.29 11.5 0.0 4.0 4 0 0 4 4 4 3 PPR repeat PPR_long PF17177.4 EFA75260.1 - 7.5e-06 25.5 0.4 7.5e-06 25.5 0.4 2.0 2 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP Nup160 PF11715.8 EFA75260.1 - 2.9e-05 22.9 1.4 0.61 8.7 0.1 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 PPR_1 PF12854.7 EFA75260.1 - 7.9e-05 22.3 0.7 0.16 11.7 0.0 3.3 3 0 0 3 3 3 2 PPR repeat Coatomer_WDAD PF04053.14 EFA75260.1 - 0.00041 19.5 8.1 0.0073 15.4 0.1 3.8 3 1 2 5 5 5 1 Coatomer WD associated region WD40_like PF17005.5 EFA75260.1 - 0.0013 18.1 7.2 0.021 14.2 0.1 4.0 4 1 0 4 4 4 1 WD40-like domain DUF3303 PF11746.8 EFA75260.1 - 0.11 12.8 0.6 3.8 7.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3303) PQQ_2 PF13360.6 EFA75260.1 - 0.17 11.5 0.0 0.73 9.4 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain EGF_2 PF07974.13 EFA75262.1 - 0.0019 18.5 12.8 0.0065 16.8 12.8 2.0 1 0 0 1 1 1 1 EGF-like domain Podoplanin PF05808.11 EFA75262.1 - 0.0052 16.9 0.9 0.012 15.7 0.9 1.5 1 0 0 1 1 1 1 Podoplanin VSP PF03302.13 EFA75262.1 - 0.022 13.6 0.5 0.038 12.8 0.5 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein Beta-APP PF03494.13 EFA75262.1 - 0.057 13.3 1.6 0.14 12.1 1.6 1.6 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) S1FA PF04689.13 EFA75262.1 - 0.25 11.5 0.9 1.4 9.1 0.1 2.5 2 0 0 2 2 2 0 DNA binding protein S1FA EGF PF00008.27 EFA75262.1 - 0.55 10.6 11.0 1.2 9.6 11.0 1.6 1 0 0 1 1 1 0 EGF-like domain LCM PF04072.14 EFA75263.1 - 7.7e-33 114.0 0.0 1.2e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase IF2_N PF04760.15 EFA75263.1 - 0.76 9.6 3.7 22 5.0 0.3 3.2 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region IucA_IucC PF04183.12 EFA75264.1 - 2.8e-28 99.1 0.0 3.8e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 IucA / IucC family ENTH PF01417.20 EFA75264.1 - 0.064 13.3 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 ENTH domain DUF2207 PF09972.9 EFA75267.1 - 0.0064 15.3 0.8 0.0085 14.9 0.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) BRI3BP PF14965.6 EFA75267.1 - 0.0085 15.6 0.4 0.011 15.2 0.4 1.1 1 0 0 1 1 1 1 Negative regulator of p53/TP53 Erf4 PF10256.9 EFA75267.1 - 0.041 14.0 0.2 0.095 12.8 0.1 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family E1-E2_ATPase PF00122.20 EFA75268.1 - 6.9e-44 149.5 1.9 6.9e-44 149.5 1.9 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFA75268.1 - 2.5e-36 126.0 0.4 4.4e-36 125.1 0.4 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA75268.1 - 4e-07 30.0 8.9 3.7e-06 26.9 0.6 2.8 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase EGF_2 PF07974.13 EFA75269.1 - 1.5 9.2 9.8 0.23 11.9 5.2 2.1 2 0 0 2 2 2 0 EGF-like domain EF-hand_7 PF13499.6 EFA75270.1 - 2.2e-17 63.3 6.1 6.5e-06 26.5 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFA75270.1 - 2.8e-13 48.4 14.1 0.00024 20.4 0.4 4.9 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EFA75270.1 - 7.4e-11 41.1 16.0 0.013 15.4 0.1 5.6 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EFA75270.1 - 1.7e-08 34.1 9.8 0.0048 16.7 0.4 4.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA75270.1 - 3.4e-07 29.5 11.3 0.003 17.0 0.9 3.6 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 EFA75270.1 - 8.5e-06 25.7 3.4 0.34 10.9 0.1 3.5 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFA75270.1 - 0.00073 19.8 1.2 0.96 9.8 0.0 3.3 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region DUF3730 PF12530.8 EFA75271.1 - 1.4e-38 132.7 5.2 3.9e-38 131.3 0.6 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3730) HEAT_EZ PF13513.6 EFA75271.1 - 0.0027 18.2 4.5 0.29 11.7 0.6 4.7 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 EFA75271.1 - 0.38 11.2 7.6 11 6.5 0.2 5.7 5 0 0 5 5 5 0 HEAT repeat EF-G-binding_N PF07299.11 EFA75271.1 - 1.4 9.5 6.1 12 6.5 0.0 5.0 4 0 0 4 4 4 0 Elongation factor G-binding protein, N-terminal EGF_2 PF07974.13 EFA75274.1 - 0.0031 17.8 12.8 0.0068 16.8 12.8 1.6 1 0 0 1 1 1 1 EGF-like domain VSP PF03302.13 EFA75274.1 - 0.0045 15.9 0.7 0.0079 15.1 0.7 1.3 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.11 EFA75274.1 - 0.1 12.7 2.0 0.2 11.8 2.0 1.4 1 0 0 1 1 1 0 Podoplanin Beta-APP PF03494.13 EFA75274.1 - 0.23 11.3 1.3 0.57 10.1 1.3 1.6 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) EGF PF00008.27 EFA75274.1 - 0.63 10.4 11.0 1.2 9.5 11.0 1.5 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA75274.1 - 3.4 8.4 11.2 11 6.9 11.2 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF Cornifin PF02389.15 EFA75275.1 - 0.013 15.7 4.1 0.019 15.2 4.1 1.2 1 0 0 1 1 1 0 Cornifin (SPRR) family AIRS_C PF02769.22 EFA75276.1 - 7.3e-25 87.9 0.0 1e-24 87.5 0.0 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 EFA75276.1 - 1.2e-09 38.6 0.0 3.1e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain CBM49 PF09478.10 EFA75277.1 - 7.8e-18 64.6 0.2 1.1e-17 64.1 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 EFA75277.1 - 0.039 14.3 0.5 0.068 13.5 0.5 1.4 1 0 0 1 1 1 0 Cellulose binding domain Myticin-prepro PF10690.9 EFA75277.1 - 0.066 13.5 0.2 0.1 12.8 0.2 1.4 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel DUF11 PF01345.18 EFA75277.1 - 0.52 10.7 2.5 1.6 9.0 0.8 2.0 1 1 1 2 2 2 0 Domain of unknown function DUF11 Ank_4 PF13637.6 EFA75278.1 - 6.1e-25 87.3 1.0 9.4e-11 42.0 0.0 5.6 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75278.1 - 3.7e-14 53.1 3.8 0.00089 19.8 0.2 4.5 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75278.1 - 6.8e-10 39.0 2.4 8.4 6.9 0.0 6.5 4 1 3 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75278.1 - 2.2e-09 36.8 2.9 5.3 7.9 0.0 7.3 6 2 2 8 8 8 2 Ankyrin repeat Med25 PF11232.8 EFA75278.1 - 0.0099 15.9 2.1 0.065 13.2 0.1 2.5 2 1 0 2 2 2 1 Mediator complex subunit 25 PTOV activation and synapsin 2 Med4 PF10018.9 EFA75278.1 - 0.13 12.0 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 PHR PF08005.12 EFA75279.1 - 7e-33 114.4 0.9 7e-33 114.4 0.9 3.8 4 0 0 4 4 4 1 PHR domain zf-RING_2 PF13639.6 EFA75279.1 - 5.6e-08 33.0 6.9 5.6e-08 33.0 6.9 4.8 6 0 0 6 6 6 1 Ring finger domain ANAPC10 PF03256.16 EFA75279.1 - 3.4e-05 23.6 0.0 8.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-B_box PF00643.24 EFA75279.1 - 0.00042 20.4 4.8 0.00042 20.4 4.8 4.9 5 1 0 5 5 5 1 B-box zinc finger zf-RING_UBOX PF13445.6 EFA75279.1 - 0.0011 18.9 1.9 0.0011 18.9 1.9 3.7 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_11 PF17123.5 EFA75279.1 - 0.002 17.9 5.7 0.0084 15.8 5.7 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EFA75279.1 - 0.0038 17.1 5.7 0.0038 17.1 5.7 4.4 5 0 0 5 5 5 1 zinc-RING finger domain RCC1 PF00415.18 EFA75279.1 - 0.015 15.9 0.0 0.048 14.3 0.0 1.9 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat TFCD_C PF12612.8 EFA75279.1 - 0.11 12.3 1.0 1.4 8.7 0.2 3.2 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal Glyco_tranf_2_3 PF13641.6 EFA75280.1 - 0.011 15.7 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Ank_2 PF12796.7 EFA75281.1 - 6.7e-31 106.7 3.8 2.7e-07 31.1 0.0 7.1 5 2 0 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75281.1 - 5.9e-25 87.0 7.2 0.0063 16.8 0.0 12.2 6 5 7 13 13 13 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75281.1 - 7.1e-20 71.1 4.5 0.0035 17.9 0.1 8.7 5 3 2 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75281.1 - 2.2e-09 36.8 0.2 82 4.3 0.0 11.1 9 2 2 11 11 11 0 Ankyrin repeat KOG2701 PF09762.9 EFA75281.1 - 0.026 14.8 0.3 7.8 6.7 0.0 3.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein (DUF2037) TMEM95 PF15203.6 EFA75281.1 - 0.027 14.1 0.2 3.1 7.4 0.0 3.2 2 0 0 2 2 2 0 TMEM95 family Ndc80_HEC PF03801.13 EFA75281.1 - 0.048 13.3 1.3 4.7 6.8 0.1 3.1 2 0 0 2 2 2 0 HEC/Ndc80p family NOT2_3_5 PF04153.18 EFA75281.1 - 0.063 13.4 9.8 1.1 9.4 0.1 3.6 4 0 0 4 4 4 0 NOT2 / NOT3 / NOT5 family TRCF PF03461.15 EFA75281.1 - 0.34 11.3 7.4 3.6 8.0 0.3 2.5 2 0 0 2 2 2 0 TRCF domain Xin PF08043.12 EFA75281.1 - 0.44 10.2 2.8 23 4.8 0.2 2.8 2 0 0 2 2 2 0 Xin repeat DUF1945 PF09178.10 EFA75281.1 - 0.54 10.5 4.1 19 5.5 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1945) DUF5078 PF16877.5 EFA75281.1 - 0.96 9.9 5.3 0.26 11.8 0.2 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF5078) DUF3986 PF13143.6 EFA75281.1 - 4.6 8.3 12.0 9.8 7.2 0.3 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3986) zf-A20 PF01754.16 EFA75282.1 - 2.7e-11 43.2 9.7 1.2e-10 41.1 9.7 2.3 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 EFA75282.1 - 6.7e-05 23.0 8.7 6.7e-05 23.0 8.7 1.8 2 0 0 2 2 2 1 AN1-like Zinc finger DUF5556 PF17711.1 EFA75282.1 - 0.023 14.6 0.2 0.023 14.6 0.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5556) Mitofilin PF09731.9 EFA75282.1 - 1.3 7.7 10.9 1.7 7.4 10.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CIMR PF00878.18 EFA75284.1 - 3e-07 30.6 1.6 0.00036 20.6 0.1 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EFA75284.1 - 4.3e-07 30.1 0.1 1e-06 28.8 0.1 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 PRKCSH_1 PF13015.6 EFA75284.1 - 0.00036 20.3 0.0 0.00054 19.7 0.0 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EFA75286.1 - 2.9e-09 37.2 0.1 3.7e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EFA75286.1 - 1.5e-08 34.8 1.0 1.6e-05 25.0 0.3 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat PRKCSH_1 PF13015.6 EFA75286.1 - 0.00074 19.2 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein SUIM_assoc PF16619.5 EFA75288.1 - 0.0027 17.7 3.6 0.0027 17.7 3.6 6.7 7 1 0 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 zf-C3HC4_3 PF13920.6 EFA75289.1 - 2.1e-12 46.7 11.9 3.2e-12 46.1 11.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA75289.1 - 5.7e-07 29.3 12.3 9.4e-07 28.6 12.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 K-box PF01486.17 EFA75289.1 - 9.8e-05 22.5 7.6 9.8e-05 22.5 7.6 3.1 2 1 1 3 3 3 1 K-box region GARP PF16731.5 EFA75289.1 - 0.011 15.4 1.6 0.011 15.4 1.6 1.8 2 1 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF4392 PF14336.6 EFA75289.1 - 0.068 12.6 1.7 0.18 11.2 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4392) zf-RING_2 PF13639.6 EFA75289.1 - 0.074 13.4 13.2 0.13 12.6 13.2 1.4 1 0 0 1 1 1 0 Ring finger domain DUF2039 PF10217.9 EFA75289.1 - 0.086 13.2 4.8 0.23 11.9 4.8 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) ENT PF03735.14 EFA75289.1 - 0.24 11.5 7.4 8.4 6.5 2.9 3.0 2 1 0 2 2 2 0 ENT domain Ribosomal_S13 PF00416.22 EFA75289.1 - 0.4 11.1 2.9 0.22 11.9 0.7 1.7 2 0 0 2 2 2 0 Ribosomal protein S13/S18 WbqC PF08889.11 EFA75289.1 - 0.46 10.4 3.7 0.28 11.1 1.3 1.8 1 1 0 2 2 2 0 WbqC-like protein family Kelch_4 PF13418.6 EFA75290.1 - 1.1e-30 105.4 7.0 3e-09 36.8 0.0 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA75290.1 - 6e-23 80.6 13.6 5.1e-06 26.6 0.0 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA75290.1 - 2.3e-22 78.5 3.7 6.1e-06 26.1 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EFA75290.1 - 1.2e-19 69.8 10.4 1.4e-07 31.5 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFA75290.1 - 1.6e-14 53.2 10.3 0.00087 19.2 0.1 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFA75290.1 - 6.8e-11 41.6 17.4 0.0013 18.3 0.5 5.2 6 0 0 6 6 6 3 Kelch motif RAG2 PF03089.14 EFA75290.1 - 0.27 10.2 8.4 0.84 8.6 0.0 3.7 2 1 2 5 5 5 0 Recombination activating protein 2 Nucleo_P87 PF07267.11 EFA75290.1 - 2.6 6.8 5.1 3.2 6.5 5.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Dicty_REP PF05086.12 EFA75290.1 - 9.9 4.0 10.8 13 3.6 10.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pirin PF02678.16 EFA75291.1 - 2.1e-35 121.0 0.1 3.6e-35 120.2 0.1 1.3 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EFA75291.1 - 3.5e-23 81.9 0.0 2.8e-22 79.0 0.0 2.0 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EFA75291.1 - 0.12 12.2 0.5 3.9 7.3 0.2 2.3 2 0 0 2 2 2 0 Cupin domain DUF3399 PF11879.8 EFA75291.1 - 0.44 10.9 1.0 0.74 10.2 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) Beach PF02138.18 EFA75292.1 - 3.1e-125 417.1 2.7 3.9e-125 416.8 0.9 2.2 2 0 0 2 2 2 1 Beige/BEACH domain DUF4704 PF15787.5 EFA75292.1 - 6.6e-67 225.7 28.3 8.1e-67 225.4 6.0 5.4 4 1 0 4 4 4 3 Domain of unknown function (DUF4704) PH_BEACH PF14844.6 EFA75292.1 - 6.9e-26 90.3 1.2 2.3e-25 88.6 0.2 2.6 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EFA75292.1 - 3.8e-17 62.3 11.6 4.3e-07 30.5 0.3 6.0 4 1 1 5 5 5 4 WD domain, G-beta repeat DUF4800 PF16057.5 EFA75292.1 - 8.3e-13 48.2 3.6 8.3e-13 48.2 3.6 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4800) ANAPC4_WD40 PF12894.7 EFA75292.1 - 0.00013 22.2 0.3 1.3 9.4 0.1 4.2 1 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain STAG PF08514.11 EFA75292.1 - 0.59 10.1 7.0 5.3 7.0 0.1 3.3 3 0 0 3 3 3 0 STAG domain SdrD_B PF17210.3 EFA75293.1 - 6.1e-17 61.9 1.2 1.6e-11 44.4 0.1 2.5 2 0 0 2 2 2 2 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA75293.1 - 4.4e-07 30.1 0.0 0.01 16.1 0.0 2.8 2 1 0 2 2 2 2 Carboxypeptidase regulatory-like domain TTR-52 PF01060.23 EFA75293.1 - 0.012 16.2 0.0 0.064 14.0 0.0 2.3 2 0 0 2 2 2 0 Transthyretin-like family DUF4222 PF13973.6 EFA75293.1 - 0.057 13.0 0.7 3.5 7.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4222) TPR_19 PF14559.6 EFA75294.1 - 2.8e-12 46.9 0.9 5.9e-08 33.1 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA75294.1 - 3.1e-08 33.8 4.2 5.3 7.4 0.0 6.7 4 2 2 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA75294.1 - 9.4e-07 29.2 0.1 0.23 12.4 0.1 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA75294.1 - 1.2e-05 25.4 10.9 0.00013 22.1 0.4 4.4 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EFA75294.1 - 0.0051 16.6 15.2 1.6 8.7 0.0 6.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA75294.1 - 0.013 16.1 0.1 25 5.6 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA75294.1 - 0.049 13.7 2.0 30 5.0 0.0 5.4 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA75294.1 - 0.17 12.2 8.2 27 5.3 0.0 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFA75294.1 - 0.2 11.3 0.4 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_2 PF07719.17 EFA75294.1 - 0.46 10.7 15.4 14 6.1 0.0 6.7 8 1 1 9 9 9 0 Tetratricopeptide repeat Pex14_N PF04695.13 EFA75295.1 - 2.3e-34 119.3 8.6 2.3e-34 119.3 8.6 6.9 3 1 2 6 6 6 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5572 PF17733.1 EFA75295.1 - 9.6e-06 25.4 0.2 6.7e-05 22.6 0.2 2.7 1 0 0 1 1 1 1 Family of unknown function (DUF5572) SUIM_assoc PF16619.5 EFA75295.1 - 0.0034 17.4 0.0 0.0034 17.4 0.0 10.4 7 3 2 9 9 9 1 Unstructured region C-term to UIM in Ataxin3 RhoGEF PF00621.20 EFA75296.1 - 1.7e-17 64.2 2.1 2.1e-16 60.7 0.5 2.4 2 0 0 2 2 2 1 RhoGEF domain Arm PF00514.23 EFA75296.1 - 1.7e-07 31.0 17.8 6.1e-05 22.9 0.1 6.7 5 2 3 8 8 8 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EFA75296.1 - 0.017 15.2 4.4 0.048 13.7 4.4 1.8 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EFA75296.1 - 0.019 14.9 5.4 0.019 14.9 5.4 3.1 2 1 2 4 4 4 0 Domain of unknown function (DUF3361) HEAT_EZ PF13513.6 EFA75296.1 - 0.034 14.7 0.0 7.7 7.1 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat RICTOR_V PF14668.6 EFA75296.1 - 0.14 12.4 1.9 44 4.4 0.0 3.7 3 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 EFA75296.1 - 0.59 10.3 5.7 0.3 11.2 1.4 2.6 2 1 1 3 3 3 0 V-ATPase subunit H GGA_N-GAT PF18308.1 EFA75296.1 - 1.2 8.8 6.4 3.2 7.5 0.2 3.2 3 0 0 3 3 3 0 GGA N-GAT domain Endotoxin_N PF03945.14 EFA75298.1 - 0.012 15.4 0.0 0.038 13.7 0.0 1.7 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain DUF2316 PF10078.9 EFA75298.1 - 0.06 13.6 0.3 0.12 12.6 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) PG_binding_1 PF01471.18 EFA75299.1 - 2.4e-07 30.8 0.1 3e-06 27.3 0.1 2.8 2 0 0 2 2 2 1 Putative peptidoglycan binding domain TFIIA PF03153.13 EFA75299.1 - 0.53 10.2 41.5 0.2 11.6 24.9 2.8 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.22 EFA75300.1 - 1.9e-14 53.2 0.1 2.9e-14 52.6 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EFA75300.1 - 1.6e-10 40.5 13.6 1.6e-05 24.7 3.5 2.4 2 0 0 2 2 2 2 Zinc knuckle Limkain-b1 PF11608.8 EFA75300.1 - 0.00039 20.4 0.1 0.00093 19.2 0.1 1.6 1 0 0 1 1 1 1 Limkain b1 RRM_5 PF13893.6 EFA75300.1 - 0.0044 16.6 0.0 0.0066 16.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFA75300.1 - 0.016 15.3 0.1 0.029 14.4 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_7 PF16367.5 EFA75300.1 - 0.02 15.0 0.0 1.5 9.0 0.0 2.3 1 1 0 1 1 1 0 RNA recognition motif zf-CCHC_4 PF14392.6 EFA75300.1 - 0.043 13.6 7.1 1.8 8.4 1.3 2.3 2 0 0 2 2 2 0 Zinc knuckle DUF1866 PF08952.11 EFA75300.1 - 0.046 13.6 0.0 0.066 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) DnaJ_CXXCXGXG PF00684.19 EFA75300.1 - 0.062 13.7 7.8 0.16 12.4 7.8 1.7 1 1 0 1 1 1 0 DnaJ central domain Nup35_RRM_2 PF14605.6 EFA75300.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCHC_3 PF13917.6 EFA75300.1 - 0.17 11.8 10.2 0.21 11.6 1.8 2.7 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.6 EFA75300.1 - 5 6.9 14.8 2.4 7.9 2.5 3.2 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger ELFV_dehydrog PF00208.21 EFA75301.1 - 3.5e-54 184.1 0.0 5.5e-54 183.5 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EFA75301.1 - 7e-22 76.9 0.0 1e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EFA75301.1 - 0.0038 17.1 0.0 0.19 11.6 0.0 2.6 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain EGF_2 PF07974.13 EFA75302.1 - 0.0051 17.1 11.5 0.011 16.0 11.5 1.6 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA75302.1 - 0.52 10.7 8.0 1.2 9.5 8.0 1.6 1 0 0 1 1 1 0 EGF-like domain Takusan PF04822.13 EFA75302.1 - 2.4 8.1 10.4 8.1 6.4 10.4 1.8 1 0 0 1 1 1 0 Takusan VSP PF03302.13 EFA75303.1 - 0.011 14.7 1.0 0.018 13.9 1.0 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein EGF_2 PF07974.13 EFA75303.1 - 0.014 15.8 12.4 0.028 14.8 12.4 1.6 1 0 0 1 1 1 0 EGF-like domain Podoplanin PF05808.11 EFA75303.1 - 0.033 14.3 1.2 0.066 13.3 1.2 1.4 1 0 0 1 1 1 0 Podoplanin EphA2_TM PF14575.6 EFA75303.1 - 0.12 13.3 0.9 0.24 12.3 0.9 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EGF PF00008.27 EFA75303.1 - 0.42 11.0 10.4 0.79 10.1 10.4 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA75304.1 - 0.0086 16.4 12.4 0.023 15.1 12.4 1.8 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA75304.1 - 0.28 11.5 10.4 0.64 10.4 10.4 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA75306.1 - 2.7e-08 34.0 51.0 0.012 15.9 10.7 3.7 3 0 0 3 3 3 3 EGF-like domain EphA2_TM PF14575.6 EFA75306.1 - 2.1e-07 31.7 1.6 0.39 11.6 0.0 3.6 3 0 0 3 3 3 2 Ephrin type-A receptor 2 transmembrane domain S1FA PF04689.13 EFA75306.1 - 8.5e-06 25.8 4.0 2.3 8.4 0.1 3.5 3 0 0 3 3 3 3 DNA binding protein S1FA DAP10 PF07213.11 EFA75306.1 - 4.1e-05 23.5 0.1 7.7 6.5 0.0 3.8 3 0 0 3 3 3 3 DAP10 membrane protein LapA_dom PF06305.11 EFA75306.1 - 0.00015 21.5 7.8 1.2 9.0 0.2 3.5 3 0 0 3 3 3 3 Lipopolysaccharide assembly protein A domain DUF3970 PF13113.6 EFA75306.1 - 0.0075 16.5 4.2 19 5.6 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3970) Med7 PF05983.11 EFA75306.1 - 0.028 14.5 0.7 65 3.5 0.0 3.4 3 0 0 3 3 3 0 MED7 protein YajC PF02699.15 EFA75306.1 - 0.029 14.3 0.5 32 4.5 0.1 3.9 4 0 0 4 4 4 0 Preprotein translocase subunit E1_UFD PF09358.10 EFA75306.1 - 0.078 13.7 0.0 32 5.3 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin fold domain Phage_holin_3_6 PF07332.11 EFA75306.1 - 0.13 12.3 1.1 25 5.0 0.0 2.7 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III EGF PF00008.27 EFA75306.1 - 0.18 12.2 46.6 2.1 8.7 9.0 3.5 3 0 0 3 3 3 0 EGF-like domain Beta-APP PF03494.13 EFA75306.1 - 0.39 10.6 17.2 5.7 6.9 1.7 3.7 3 0 0 3 3 3 0 Beta-amyloid peptide (beta-APP) DoxA PF07680.11 EFA75306.1 - 0.6 10.0 3.2 2.5 8.0 0.1 3.5 4 0 0 4 4 4 0 TQO small subunit DoxA DUF5518 PF17647.1 EFA75306.1 - 1.3 9.2 14.8 15 5.8 1.0 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5518) CBP_BcsR PF10945.8 EFA75306.1 - 2.4 7.7 5.6 93 2.6 0.1 3.8 4 0 0 4 4 4 0 Cellulose biosynthesis protein BcsR PS_Dcarbxylase PF02666.15 EFA75307.1 - 1.4e-61 207.5 0.0 1.8e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase TMEM189_B_dmain PF10520.9 EFA75308.1 - 1.7e-73 246.4 3.8 1.7e-73 246.4 3.8 1.8 2 0 0 2 2 2 1 B domain of TMEM189, localisation domain RR_TM4-6 PF06459.12 EFA75308.1 - 0.0035 17.2 2.7 0.0049 16.7 2.7 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 EMC3_TMCO1 PF01956.16 EFA75308.1 - 0.0051 16.6 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DUF3333 PF11812.8 EFA75308.1 - 0.33 11.1 1.5 0.62 10.2 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) FA_hydroxylase PF04116.13 EFA75308.1 - 0.68 10.3 10.2 0.37 11.1 7.0 2.0 1 1 1 2 2 2 0 Fatty acid hydroxylase superfamily ALMT PF11744.8 EFA75308.1 - 3.5 6.4 7.8 5.1 5.8 7.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Cation_ATPase_C PF00689.21 EFA75309.1 - 3.7e-44 150.6 7.5 3.7e-44 150.6 7.5 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFA75309.1 - 1.3e-35 122.6 0.3 1.3e-35 122.6 0.3 3.4 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFA75309.1 - 2.2e-21 75.8 0.0 4.3e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA75309.1 - 1.1e-16 61.7 0.0 2.6e-16 60.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA75309.1 - 3.5e-15 55.5 0.0 7.8e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA75309.1 - 0.00013 21.8 0.2 0.032 14.0 0.2 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Colicin_im PF03857.13 EFA75309.1 - 0.0016 18.4 3.6 0.0047 16.9 3.6 1.7 1 0 0 1 1 1 1 Colicin immunity protein Wzy_C PF04932.15 EFA75309.1 - 0.17 11.5 3.3 0.43 10.2 0.1 2.9 3 0 0 3 3 3 0 O-Antigen ligase Pkinase_Tyr PF07714.17 EFA75310.1 - 4.2e-45 154.1 0.0 5.3e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75310.1 - 5e-42 144.1 0.0 6.6e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Cbl_N2 PF02761.14 EFA75310.1 - 0.068 13.9 0.0 0.17 12.6 0.0 1.7 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain Pirin PF02678.16 EFA75311.1 - 1.2e-35 121.7 0.1 2e-35 121.0 0.1 1.3 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EFA75311.1 - 8.8e-28 96.7 0.0 7.1e-27 93.8 0.0 2.1 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EFA75311.1 - 0.089 12.5 0.3 3.4 7.4 0.2 2.3 2 0 0 2 2 2 0 Cupin domain KOW PF00467.29 EFA75311.1 - 0.098 12.6 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 KOW motif Glyco_hydro_3 PF00933.21 EFA75312.1 - 6.4e-64 216.3 0.0 9.2e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFA75312.1 - 8.1e-42 143.5 0.0 1.5e-41 142.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFA75312.1 - 1.8e-13 50.3 0.2 3.8e-13 49.4 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain TBP-binding PF09247.11 EFA75312.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 TATA box-binding protein binding Ly49 PF08391.10 EFA75312.1 - 0.33 11.3 1.3 0.58 10.5 1.3 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region AJAP1_PANP_C PF15298.6 EFA75313.1 - 0.91 9.7 14.8 1.8 8.7 14.8 1.5 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Mucin PF01456.17 EFA75313.1 - 2.2 8.3 28.8 4 7.4 28.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Sir1 PF11603.8 EFA75313.1 - 5 7.6 13.0 0.22 12.0 3.0 3.3 4 1 0 4 4 4 0 Regulatory protein Sir1 Tir_receptor_C PF07489.11 EFA75313.1 - 7.9 6.4 14.4 13 5.7 14.4 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Rad51 PF08423.11 EFA75314.1 - 1.6e-45 155.3 0.4 4.2e-41 140.9 0.3 2.5 2 0 0 2 2 2 2 Rad51 ATPase PF06745.13 EFA75314.1 - 2.4e-07 30.3 0.9 8.4e-07 28.6 0.9 2.0 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EFA75314.1 - 2.5e-07 30.5 0.0 5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EFA75314.1 - 7.2e-07 28.8 0.8 1.8e-06 27.5 0.8 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Ank_4 PF13637.6 EFA75314.1 - 6.3e-06 26.6 2.8 0.066 13.8 0.0 5.8 5 2 2 7 7 6 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75314.1 - 7.1e-06 26.5 0.1 0.061 13.9 0.0 4.6 1 1 4 5 5 5 2 Ankyrin repeats (3 copies) RecA PF00154.21 EFA75314.1 - 5.8e-05 22.7 2.8 0.029 13.9 0.2 2.3 2 0 0 2 2 2 2 recA bacterial DNA recombination protein Ank_3 PF13606.6 EFA75314.1 - 0.0014 18.9 2.0 0.63 10.8 0.0 5.5 7 0 0 7 7 5 1 Ankyrin repeat AAA_22 PF13401.6 EFA75314.1 - 0.0072 16.6 0.8 0.028 14.7 0.8 2.0 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EFA75314.1 - 0.057 13.3 0.1 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 EFA75314.1 - 0.061 13.7 0.0 0.16 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EFA75314.1 - 0.068 13.6 0.3 0.52 10.7 0.2 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ank_5 PF13857.6 EFA75314.1 - 0.087 13.2 10.2 0.26 11.7 0.0 6.1 9 1 0 9 9 6 0 Ankyrin repeats (many copies) ABC_tran PF00005.27 EFA75314.1 - 0.52 10.8 3.6 2.2 8.8 3.6 2.3 1 1 0 1 1 1 0 ABC transporter Putative_PNPOx PF01243.20 EFA75315.1 - 9.1e-23 80.3 1.1 6e-22 77.6 0.0 2.4 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 EFA75315.1 - 3.4e-14 52.6 0.9 7.1e-14 51.6 0.9 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyrid_ox_like PF16242.5 EFA75315.1 - 0.022 14.3 0.0 0.071 12.7 0.0 1.9 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like CENP-B_dimeris PF09026.10 EFA75315.1 - 0.063 13.7 2.5 0.17 12.3 2.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain YitT_membrane PF02588.15 EFA75316.1 - 0.014 14.8 0.0 0.014 14.7 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised 5xTM membrane BCR, YitT family COG1284 MFS_1 PF07690.16 EFA75317.1 - 1.5e-32 112.9 14.5 2.2e-32 112.4 14.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EFA75317.1 - 8e-05 21.1 4.6 8e-05 21.1 4.6 2.8 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF3796 PF12676.7 EFA75317.1 - 0.0085 16.5 1.4 0.0085 16.5 1.4 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3796) FNIP PF05725.12 EFA75318.1 - 2.4e-15 56.4 22.1 0.0013 18.9 0.1 6.7 5 1 2 7 7 7 5 FNIP Repeat F-box-like PF12937.7 EFA75318.1 - 0.021 14.7 0.6 0.046 13.6 0.6 1.6 1 0 0 1 1 1 0 F-box-like F-box_5 PF18511.1 EFA75318.1 - 0.022 14.3 0.6 0.045 13.3 0.2 1.7 2 0 0 2 2 2 0 F-box LRR_1 PF00560.33 EFA75318.1 - 0.11 13.1 3.4 1e+02 4.1 0.0 4.7 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 EFA75318.1 - 0.33 11.4 19.0 18 5.9 1.4 6.3 4 2 1 6 6 6 0 Leucine Rich repeats (2 copies) Big_9 PF17963.1 EFA75319.1 - 2.7e-17 63.3 63.3 0.00019 22.1 0.0 13.3 13 2 1 14 14 14 5 Bacterial Ig domain Cadherin_4 PF17803.1 EFA75319.1 - 0.00015 22.3 36.9 0.035 14.7 0.3 9.4 9 0 0 9 9 9 3 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFA75319.1 - 0.0016 18.4 27.2 0.11 12.5 0.2 9.1 9 1 0 9 9 9 2 Cadherin-like domain UPF0730 PF15827.5 EFA75319.1 - 0.022 14.5 0.0 1 9.2 0.0 2.8 2 0 0 2 2 2 0 UPF0730 unknown protein family Integrin_beta PF00362.18 EFA75319.1 - 0.032 13.9 0.1 0.071 12.8 0.1 1.6 1 1 0 1 1 1 0 Integrin beta chain VWA domain VWA PF00092.28 EFA75319.1 - 0.049 13.9 0.2 0.049 13.9 0.2 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain Laminin_EGF PF00053.24 EFA75319.1 - 0.11 12.6 16.2 2.1 8.6 8.1 2.7 1 1 1 2 2 2 0 Laminin EGF domain EGF PF00008.27 EFA75319.1 - 5.2 7.5 13.1 4.1 7.8 1.8 2.8 2 0 0 2 2 2 0 EGF-like domain Ank_5 PF13857.6 EFA75320.1 - 3.4e-16 59.1 2.4 0.0024 18.1 0.1 7.1 2 1 4 7 7 7 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75320.1 - 2.3e-15 56.9 0.8 9.7e-05 22.9 0.0 4.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75320.1 - 1.1e-13 51.4 4.9 0.011 16.2 0.1 6.9 7 0 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75320.1 - 3.1e-08 33.2 1.2 31 5.6 0.0 7.9 9 0 0 9 9 9 0 Ankyrin repeat DUF5049 PF16468.5 EFA75320.1 - 5.5e-06 26.2 0.0 0.58 10.1 0.0 4.3 3 1 1 4 4 4 3 Domain of unknown function (DUF5049) DUF249 PF03158.13 EFA75320.1 - 0.00027 20.7 2.9 2.4 7.8 0.0 4.1 1 1 3 4 4 4 3 Multigene family 530 protein TraG-D_C PF12696.7 EFA75320.1 - 0.093 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG Inhibitor_I29 PF08246.12 EFA75321.1 - 4.5e-11 43.0 1.0 1.2e-10 41.7 1.0 1.7 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) IRF PF00605.17 EFA75321.1 - 0.00058 20.1 0.2 0.001 19.3 0.2 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor CYYR1 PF10873.8 EFA75321.1 - 0.072 13.5 0.3 0.14 12.6 0.3 1.5 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Ac76 PF05814.11 EFA75321.1 - 0.13 12.3 1.6 0.13 12.3 0.2 1.8 2 0 0 2 2 2 0 Orf76 (Ac76) Gram_pos_anchor PF00746.21 EFA75321.1 - 2.5 8.1 8.3 5.8 6.9 1.2 2.4 1 1 1 2 2 2 0 LPXTG cell wall anchor motif Peptidase_C1 PF00112.23 EFA75322.1 - 1.7e-56 191.8 4.6 1.7e-56 191.8 4.6 1.6 2 0 0 2 2 2 1 Papain family cysteine protease CAP PF00188.26 EFA75322.1 - 3.9e-07 30.9 2.6 1.2e-06 29.4 2.6 1.8 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C39_2 PF13529.6 EFA75322.1 - 0.0054 17.3 0.1 0.015 15.9 0.1 1.8 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C1_2 PF03051.15 EFA75322.1 - 0.063 12.1 0.8 4.9 5.8 0.1 2.1 2 0 0 2 2 2 0 Peptidase C1-like family BtrH_N PF14399.6 EFA75322.1 - 0.081 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal MSA-2c PF12238.8 EFA75322.1 - 0.11 12.5 11.0 0.22 11.5 11.0 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF4106 PF13388.6 EFA75322.1 - 2 7.6 6.3 2.8 7.1 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Ank_4 PF13637.6 EFA75323.1 - 1.2e-15 57.7 2.0 0.00051 20.6 0.1 6.4 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75323.1 - 3e-12 46.5 5.9 0.0026 18.0 0.1 7.1 5 2 3 8 8 8 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75323.1 - 3.9e-12 46.6 5.0 0.0011 19.6 0.8 3.8 1 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75323.1 - 2.4e-09 36.7 4.6 0.75 10.6 0.0 8.0 7 1 1 8 8 8 1 Ankyrin repeat NOP19 PF10863.8 EFA75323.1 - 0.13 12.1 1.4 0.47 10.3 1.4 1.9 1 1 0 1 1 1 0 Nucleolar protein 19 Cnd1 PF12717.7 EFA75323.1 - 1.5 8.9 4.6 1.2 9.2 0.2 2.7 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3447 PF11929.8 EFA75323.1 - 2.7 8.0 25.2 11 6.1 0.0 5.9 4 2 2 6 6 6 0 Domain of unknown function (DUF3447) Inhibitor_I29 PF08246.12 EFA75324.1 - 7.1e-09 36.0 1.7 1.5e-08 34.9 1.7 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) IRF PF00605.17 EFA75324.1 - 0.023 15.0 0.2 0.042 14.2 0.2 1.3 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor Peptidase_C1 PF00112.23 EFA75325.1 - 3.5e-31 109.0 0.0 3.5e-31 109.0 0.0 1.6 2 1 1 3 3 3 1 Papain family cysteine protease CAP PF00188.26 EFA75325.1 - 4.2e-08 34.1 3.8 7.9e-08 33.2 3.8 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Mito_fiss_reg PF05308.11 EFA75325.1 - 0.28 11.2 1.4 1.4 9.0 2.6 1.5 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.19 EFA75325.1 - 1.3 8.4 6.0 1.2 8.6 4.3 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Metallophos_C PF14008.6 EFA75326.1 - 7.6e-20 71.5 0.7 7.6e-20 71.5 0.7 3.0 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 EFA75326.1 - 1.7e-17 64.6 0.7 4e-17 63.4 0.5 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFA75326.1 - 2.3e-15 56.9 0.0 1e-14 54.8 0.0 2.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_PAP PF17808.1 EFA75326.1 - 0.0015 18.7 0.1 0.041 14.0 0.1 2.7 1 1 0 1 1 1 1 Fn3-like domain from Purple Acid Phosphatase AIG1 PF04548.16 EFA75328.1 - 0.035 13.4 0.5 0.074 12.4 0.5 1.5 1 0 0 1 1 1 0 AIG1 family DUSP PF06337.12 EFA75329.1 - 1.8e-12 47.7 0.2 1.8e-12 47.7 0.2 4.3 3 1 0 3 3 3 1 DUSP domain GM_CSF PF01109.17 EFA75329.1 - 0.0063 16.7 1.8 0.014 15.5 0.3 2.3 1 1 0 2 2 2 1 Granulocyte-macrophage colony-stimulating factor Ubiquitin_3 PF14836.6 EFA75329.1 - 0.025 14.6 1.4 0.11 12.6 0.0 2.6 2 1 0 2 2 2 0 Ubiquitin-like domain ubiquitin PF00240.23 EFA75329.1 - 0.025 14.3 0.0 0.082 12.7 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin family Siva PF05458.12 EFA75329.1 - 0.04 13.6 4.4 0.089 12.5 4.4 1.6 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-B_box PF00643.24 EFA75329.1 - 0.062 13.5 12.8 0.2 11.8 12.8 1.9 1 1 0 1 1 1 0 B-box zinc finger zf-B_box PF00643.24 EFA75330.1 - 0.0014 18.7 3.4 0.0014 18.7 3.4 1.6 2 0 0 2 2 2 1 B-box zinc finger Ank_2 PF12796.7 EFA75332.1 - 1.5e-06 28.7 0.2 0.026 15.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75332.1 - 8.9e-05 23.0 0.2 0.55 10.9 0.0 4.0 2 2 3 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75332.1 - 0.00012 22.2 0.0 1.2 9.9 0.0 4.6 5 0 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 EFA75332.1 - 0.025 14.9 0.1 8.9 6.8 0.0 3.8 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75333.1 - 1.1e-26 92.9 1.3 2.4e-05 24.8 0.2 6.9 4 3 1 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75333.1 - 1.6e-26 92.7 0.8 2.2e-07 31.4 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75333.1 - 4e-19 68.4 0.8 0.026 14.8 0.0 8.0 3 2 5 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75333.1 - 1.4e-11 43.5 0.0 2.6 8.9 0.0 8.7 9 0 0 9 9 9 1 Ankyrin repeat Ank PF00023.30 EFA75333.1 - 0.0089 16.4 0.1 1e+02 3.6 0.0 5.5 6 1 0 6 6 6 0 Ankyrin repeat Ank_4 PF13637.6 EFA75334.1 - 5.8e-28 96.9 10.2 0.00011 22.6 0.0 9.1 7 3 3 10 10 10 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75334.1 - 1.9e-27 95.6 5.3 0.00013 22.4 0.1 6.6 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75334.1 - 2.4e-16 59.6 8.7 1.7 9.1 0.1 11.1 6 5 7 13 13 13 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75334.1 - 3.1e-14 51.7 12.0 45 5.1 0.0 13.4 14 1 1 15 15 15 0 Ankyrin repeat DUF3447 PF11929.8 EFA75334.1 - 0.00077 19.4 17.9 0.12 12.4 0.0 5.7 4 2 1 6 6 6 3 Domain of unknown function (DUF3447) Peptidase_M24_C PF16188.5 EFA75334.1 - 0.011 15.7 5.3 2 8.6 0.0 4.4 5 0 0 5 5 5 0 C-terminal region of peptidase_M24 DUF1843 PF08898.10 EFA75334.1 - 0.021 15.3 0.3 40 4.8 0.0 4.7 6 0 0 6 6 6 0 Domain of unknown function (DUF1843) Ank_4 PF13637.6 EFA75335.1 - 7.2e-34 115.7 13.3 0.00012 22.6 0.0 10.6 7 4 2 9 9 9 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75335.1 - 9.8e-31 106.2 15.6 8.7e-06 26.2 0.1 7.8 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75335.1 - 1.9e-17 63.1 19.5 0.0019 18.5 0.0 13.2 7 3 8 15 15 15 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75335.1 - 1.1e-16 59.2 17.6 1.6 9.6 0.0 15.4 17 1 1 18 18 18 2 Ankyrin repeat DUF3447 PF11929.8 EFA75335.1 - 0.0012 18.8 39.5 0.51 10.3 0.0 8.5 6 3 5 11 11 11 4 Domain of unknown function (DUF3447) Helicase_PWI PF18149.1 EFA75335.1 - 0.0023 18.1 1.3 0.045 13.9 0.1 3.5 3 0 0 3 3 3 1 N-terminal helicase PWI domain DUF249 PF03158.13 EFA75335.1 - 0.0068 16.1 15.8 0.79 9.4 0.1 5.6 1 1 4 6 6 6 2 Multigene family 530 protein Ank PF00023.30 EFA75335.1 - 0.51 10.9 4.7 2.4e+02 2.4 0.0 6.6 6 1 1 7 7 7 0 Ankyrin repeat Ank_2 PF12796.7 EFA75337.1 - 3.7e-17 62.7 2.8 3.5e-05 24.3 0.0 5.2 3 2 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75337.1 - 9.5e-14 51.3 1.5 0.077 13.3 0.1 7.9 4 2 4 8 8 8 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75337.1 - 6.2e-13 49.0 8.7 0.074 13.7 0.2 8.1 5 3 2 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75337.1 - 4e-11 42.1 2.7 6.5 7.7 0.0 9.6 10 0 0 10 10 10 1 Ankyrin repeat Ank_2 PF12796.7 EFA75338.1 - 1.7e-11 44.5 8.9 0.00026 21.5 0.2 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75338.1 - 4.3e-10 39.9 10.0 0.00047 20.7 0.6 5.7 3 2 4 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75338.1 - 4.8e-08 33.1 9.1 0.0084 16.4 0.1 6.6 2 2 5 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75338.1 - 0.00041 20.6 6.3 8.2 7.4 0.0 6.1 8 1 0 8 8 8 2 Ankyrin repeat DUF1199 PF06712.11 EFA75339.1 - 0.022 14.8 2.0 2.2 8.4 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1199) FNIP PF05725.12 EFA75340.1 - 4.7e-14 52.3 29.2 0.00065 19.8 0.2 9.9 10 1 2 12 12 12 6 FNIP Repeat F-box_5 PF18511.1 EFA75340.1 - 0.00028 20.4 0.1 0.00056 19.4 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75340.1 - 0.00096 19.0 1.2 0.0022 17.8 1.2 1.6 1 0 0 1 1 1 1 F-box-like FNIP PF05725.12 EFA75341.1 - 1.4e-11 44.3 13.2 0.087 13.0 0.5 6.7 5 1 1 6 6 6 4 FNIP Repeat F-box_5 PF18511.1 EFA75341.1 - 0.0045 16.5 0.1 0.0089 15.6 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75341.1 - 0.019 14.8 1.3 0.044 13.7 1.3 1.6 1 0 0 1 1 1 0 F-box-like TolB_like PF15869.5 EFA75341.1 - 0.07 12.4 2.2 0.42 9.8 0.1 2.6 2 1 0 2 2 2 0 TolB-like 6-blade propeller-like Ank_4 PF13637.6 EFA75342.1 - 1.2e-33 115.0 10.4 7.4e-06 26.4 0.2 10.2 6 3 5 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75342.1 - 3.9e-32 109.9 13.0 0.00063 20.0 0.0 11.4 5 4 8 13 13 13 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75342.1 - 2e-31 108.4 10.2 1.8e-07 31.6 0.2 6.9 2 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75342.1 - 3.4e-19 66.9 12.8 0.4 11.4 0.0 13.4 12 1 2 14 14 14 3 Ankyrin repeat SMI1_KNR4 PF09346.10 EFA75342.1 - 2.3e-05 24.8 2.2 0.0018 18.7 0.5 2.8 3 0 0 3 3 3 1 SMI1 / KNR4 family (SUKH-1) Ank PF00023.30 EFA75342.1 - 0.00029 21.1 4.3 67 4.2 0.0 7.9 8 3 2 10 10 10 0 Ankyrin repeat Lipoprot_C PF08794.10 EFA75342.1 - 0.0013 18.7 0.7 18 5.3 0.0 4.1 3 1 1 4 4 4 1 Lipoprotein GNA1870 C terminal like NOP19 PF10863.8 EFA75342.1 - 0.043 13.7 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Nucleolar protein 19 ETRAMP PF09716.10 EFA75343.1 - 0.019 15.0 0.7 0.033 14.2 0.7 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Man-6-P_recep PF02157.15 EFA75343.1 - 0.21 10.6 0.4 0.32 10.1 0.4 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate receptor rve PF00665.26 EFA75345.1 - 9.6e-09 35.5 0.0 1.5e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 EFA75345.1 - 0.0078 16.0 0.2 0.04 13.7 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Cpn60_TCP1 PF00118.24 EFA75346.1 - 8.6e-26 90.6 0.0 1.9e-25 89.5 0.0 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family TerB_N PF13208.6 EFA75346.1 - 0.043 13.5 0.2 0.3 10.8 0.0 2.4 3 0 0 3 3 3 0 TerB N-terminal domain Zip PF02535.22 EFA75348.1 - 0.0092 15.2 3.6 0.0096 15.2 3.6 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Baculo_ME53 PF06061.11 EFA75348.1 - 0.018 14.3 0.3 0.022 14.0 0.3 1.1 1 0 0 1 1 1 0 Baculoviridae ME53 Presenilin PF01080.17 EFA75348.1 - 0.12 11.1 4.9 0.16 10.7 4.9 1.2 1 0 0 1 1 1 0 Presenilin SelP_N PF04592.14 EFA75348.1 - 0.6 9.5 15.9 0.13 11.7 12.3 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Pex14_N PF04695.13 EFA75348.1 - 1.1 9.8 7.0 1.7 9.3 7.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Methyltransf_PK PF05891.12 EFA75349.1 - 2.9e-45 154.5 0.1 1.4e-30 106.5 0.0 2.1 1 1 1 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EFA75349.1 - 0.0086 16.8 0.0 0.041 14.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Tn7_TnsC_Int PF11426.8 EFA75349.1 - 0.053 13.7 0.6 0.16 12.1 0.0 2.1 3 0 0 3 3 3 0 Tn7 transposition regulator TnsC WD40 PF00400.32 EFA75350.1 - 2.9e-49 164.0 28.6 1.6e-07 31.9 0.6 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75350.1 - 2.2e-20 72.8 10.9 7.8e-05 22.9 0.0 6.5 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA75350.1 - 4.6e-07 29.9 5.9 8.3e-05 22.5 0.4 3.9 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Lactonase PF10282.9 EFA75350.1 - 0.0001 21.7 0.0 1.1 8.5 0.0 3.6 2 1 2 4 4 4 2 Lactonase, 7-bladed beta-propeller PD40 PF07676.12 EFA75350.1 - 0.00015 21.6 1.2 0.11 12.4 0.3 2.9 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 EFA75350.1 - 0.0012 18.0 2.9 0.082 11.9 0.1 3.5 1 1 2 3 3 3 1 Coatomer WD associated region MraZ PF02381.18 EFA75350.1 - 0.051 13.6 0.4 3.1 7.8 0.0 2.6 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like DUF2387 PF09526.10 EFA75350.1 - 5.4 7.2 6.4 6.6 7.0 0.3 3.0 3 0 0 3 3 3 0 Probable metal-binding protein (DUF2387) Prenyltrans PF00432.21 EFA75351.1 - 2.7e-28 97.4 10.7 9.5e-09 34.9 0.1 7.3 7 1 0 7 7 7 6 Prenyltransferase and squalene oxidase repeat BTB_2 PF02214.22 EFA75352.1 - 8.9e-21 74.1 0.0 2e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.16 EFA75352.1 - 1.8e-19 70.4 4.1 3.4e-19 69.5 4.1 1.5 1 0 0 1 1 1 1 TLD vWF_A PF12450.8 EFA75352.1 - 0.059 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor BTB_3 PF16017.5 EFA75352.1 - 0.079 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain DUF2179 PF10035.9 EFA75352.1 - 0.12 12.1 0.4 0.89 9.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2179) Ank_4 PF13637.6 EFA75353.1 - 3.4e-27 94.4 3.3 9e-05 22.9 0.0 9.8 8 2 2 10 10 10 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75353.1 - 4.4e-27 94.5 6.4 3e-07 30.9 0.1 7.1 3 3 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75353.1 - 2e-14 53.4 2.9 2.2 8.7 0.0 11.9 6 4 7 14 14 14 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75353.1 - 1.2e-12 46.8 11.6 1.7 9.5 0.0 13.9 17 1 1 18 18 18 1 Ankyrin repeat BTHB PF18410.1 EFA75353.1 - 0.0097 15.7 0.0 12 5.8 0.0 3.7 3 0 0 3 3 3 1 Basic tilted helix bundle domain DUF1843 PF08898.10 EFA75353.1 - 0.063 13.8 0.1 29 5.3 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF1843) DUF3447 PF11929.8 EFA75353.1 - 4.2 7.4 22.7 0.64 10.0 0.5 7.5 2 2 7 9 9 9 0 Domain of unknown function (DUF3447) TIG PF01833.24 EFA75354.1 - 4.2e-70 231.9 87.4 2e-11 43.8 1.4 13.4 11 2 2 13 13 13 12 IPT/TIG domain DNase_II PF03265.15 EFA75354.1 - 2.9e-14 53.1 2.3 8.3e-11 41.7 0.0 3.4 3 0 0 3 3 3 2 Deoxyribonuclease II TIG_plexin PF17960.1 EFA75354.1 - 0.074 13.1 0.5 0.77 9.8 0.0 3.1 3 0 0 3 3 3 0 TIG domain DASH_Duo1 PF08651.10 EFA75354.1 - 1.1 9.0 6.3 0.12 12.2 1.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Duo1 GYF PF02213.16 EFA75355.1 - 5.4e-09 35.6 0.3 1.3e-08 34.3 0.3 1.7 1 0 0 1 1 1 1 GYF domain Mucin PF01456.17 EFA75355.1 - 0.55 10.2 14.1 1 9.4 14.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EFA75355.1 - 0.71 8.0 12.6 1.1 7.4 12.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Sas10_Utp3 PF04000.15 EFA75356.1 - 1e-19 70.9 0.5 1e-19 70.9 0.5 3.7 4 1 0 4 4 4 1 Sas10/Utp3/C1D family Sas10 PF09368.10 EFA75356.1 - 1.4e-17 63.9 7.9 1.4e-17 63.9 7.9 3.7 4 0 0 4 4 4 1 Sas10 C-terminal domain RITA PF17066.5 EFA75356.1 - 0.42 10.1 5.5 0.092 12.3 0.9 2.1 2 0 0 2 2 2 0 RBPJ-interacting and tubulin associated protein Nup35_RRM PF05172.13 EFA75357.1 - 1.1e-09 38.1 1.1 2.5e-09 37.0 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EFA75357.1 - 0.021 14.8 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4283 PF14111.6 EFA75357.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) Big_9 PF17963.1 EFA75358.1 - 2.2e-10 41.2 5.3 1e-07 32.6 0.3 10.5 10 1 0 10 10 10 3 Bacterial Ig domain Cadherin_3 PF16184.5 EFA75358.1 - 1.6e-06 28.1 12.8 0.0021 18.0 0.6 5.3 5 0 0 5 5 5 3 Cadherin-like Cadherin_5 PF17892.1 EFA75358.1 - 3.8e-05 23.6 12.1 0.004 17.1 0.1 5.8 3 2 0 3 3 3 2 Cadherin-like domain Laminin_EGF PF00053.24 EFA75358.1 - 0.018 15.2 16.7 0.088 13.0 7.7 2.5 1 1 1 2 2 2 0 Laminin EGF domain EGF_2 PF07974.13 EFA75358.1 - 0.13 12.7 25.4 0.99 9.8 4.6 3.5 3 0 0 3 3 3 0 EGF-like domain EGF_Tenascin PF18720.1 EFA75358.1 - 0.26 11.4 9.2 2 8.5 3.1 2.8 2 0 0 2 2 2 0 Tenascin EGF domain DSL PF01414.19 EFA75358.1 - 2.1 8.7 19.9 0.5 10.7 9.3 2.6 2 0 0 2 2 2 0 Delta serrate ligand Cadherin_4 PF17803.1 EFA75358.1 - 3 8.5 38.6 1.7 9.3 0.1 8.8 9 0 0 9 9 9 0 Bacterial cadherin-like domain Ank_5 PF13857.6 EFA75360.1 - 1.3e-22 79.6 9.7 0.0084 16.4 0.0 9.1 4 1 5 9 9 9 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75360.1 - 2.3e-18 66.3 9.8 0.0012 19.3 0.1 8.1 6 4 2 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75360.1 - 1.7e-17 63.7 16.7 2.4e-06 28.1 0.1 5.0 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75360.1 - 3.4e-14 51.5 0.3 3.6 8.5 0.0 9.2 8 1 1 9 9 9 5 Ankyrin repeat DEP PF00610.21 EFA75360.1 - 0.25 11.4 3.5 22 5.2 0.2 5.0 4 2 1 5 5 5 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SET PF00856.28 EFA75361.1 - 8.5e-18 65.3 0.3 8.5e-18 65.3 0.3 4.1 2 2 0 2 2 2 1 SET domain RRM_1 PF00076.22 EFA75361.1 - 9.3e-07 28.6 0.0 0.0022 17.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_MCEL PF03291.16 EFA75362.1 - 2.8e-75 253.5 1.4 7.7e-75 252.1 1.4 1.7 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EFA75362.1 - 1.2e-06 29.2 0.0 2.7e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EFA75362.1 - 0.00038 19.7 0.0 0.00084 18.6 0.0 1.6 1 1 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_11 PF08241.12 EFA75362.1 - 0.00065 20.3 0.0 0.0013 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA75362.1 - 0.0083 16.9 0.0 0.0083 16.9 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA75362.1 - 0.035 13.4 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SUIM_assoc PF16619.5 EFA75363.1 - 0.0025 17.8 0.7 0.003 17.6 0.7 1.4 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 His_kinase PF06580.13 EFA75363.1 - 0.018 15.4 1.2 0.036 14.4 1.2 1.5 1 0 0 1 1 1 0 Histidine kinase Inj_translocase PF16928.5 EFA75363.1 - 0.059 12.8 4.9 0.08 12.4 4.9 1.1 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome HA2 PF04408.23 EFA75364.1 - 3.5e-22 78.7 0.0 1e-21 77.2 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 EFA75364.1 - 1.5e-07 31.4 0.1 3.7e-07 30.1 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA75364.1 - 5.1e-05 23.6 0.1 0.00066 20.0 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA75364.1 - 0.00043 20.0 0.0 0.00076 19.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA75364.1 - 0.0014 19.0 0.1 0.0036 17.6 0.1 1.7 1 0 0 1 1 1 1 AAA domain Helicase_C PF00271.31 EFA75364.1 - 0.0046 17.3 0.1 0.15 12.4 0.0 3.0 2 1 1 3 3 3 1 Helicase conserved C-terminal domain SRP54 PF00448.22 EFA75364.1 - 0.015 14.9 0.5 0.13 11.9 0.5 2.2 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EFA75364.1 - 0.052 13.6 0.1 0.81 9.7 0.1 2.6 1 1 0 1 1 1 0 AAA domain SMK-1 PF04802.15 EFA75365.1 - 1.8e-67 226.9 10.9 1.8e-67 226.9 10.9 2.1 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 SMI1_KNR4 PF09346.10 EFA75367.1 - 0.13 12.7 0.2 0.19 12.1 0.2 1.3 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Ank_2 PF12796.7 EFA75368.1 - 1.2e-27 96.3 7.6 5.5e-07 30.1 0.1 7.7 1 1 7 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75368.1 - 1e-24 86.6 7.6 0.0008 19.9 0.0 10.9 5 3 6 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75368.1 - 2.1e-15 56.6 3.3 1.9 8.9 0.0 12.1 7 3 7 14 14 14 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75368.1 - 3.6e-14 51.5 8.9 1.8 9.4 0.0 14.1 15 2 2 17 17 17 1 Ankyrin repeat DUF3447 PF11929.8 EFA75368.1 - 0.0036 17.2 30.9 0.63 10.0 1.6 8.8 3 3 4 9 9 9 2 Domain of unknown function (DUF3447) DUF3310 PF11753.8 EFA75368.1 - 0.044 14.0 0.0 0.39 10.9 0.0 2.8 1 0 0 1 1 1 0 Protein of unknwon function (DUF3310) Ank PF00023.30 EFA75368.1 - 0.075 13.5 0.6 87 3.8 0.0 5.3 5 1 0 5 5 5 0 Ankyrin repeat Methyltransf_2 PF00891.18 EFA75369.1 - 9.1e-32 110.1 0.0 1.3e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain FMO-like PF00743.19 EFA75369.1 - 1.5e-12 46.7 1.1 1.7e-08 33.3 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Methyltransf_23 PF13489.6 EFA75369.1 - 1e-06 28.7 0.0 0.00014 21.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFA75369.1 - 0.00013 22.6 0.2 0.00044 21.0 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Dimerisation2 PF16864.5 EFA75369.1 - 0.0024 17.8 0.4 0.0058 16.6 0.1 1.7 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_25 PF13649.6 EFA75369.1 - 0.056 14.1 0.0 0.17 12.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_S28 PF05577.12 EFA75370.1 - 0.008 15.0 0.3 0.0088 14.9 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Ank_5 PF13857.6 EFA75371.1 - 3.9e-13 49.3 0.3 2.5e-05 24.4 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75371.1 - 8.2e-11 42.2 0.6 0.00021 21.8 0.0 3.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75371.1 - 2.2e-05 25.0 0.1 8e-05 23.2 0.1 1.9 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75371.1 - 0.0058 17.0 0.1 48 5.0 0.0 4.3 5 0 0 5 5 5 0 Ankyrin repeat Bin3 PF06859.12 EFA75371.1 - 0.023 15.3 0.7 11 6.7 0.1 3.3 2 1 1 3 3 3 0 Bicoid-interacting protein 3 (Bin3) TSLP PF15216.6 EFA75371.1 - 0.088 13.1 0.1 6.7 7.0 0.0 2.2 1 1 1 2 2 2 0 Thymic stromal lymphopoietin TRL PF13146.6 EFA75371.1 - 0.11 12.8 0.1 5.9 7.2 0.0 2.3 1 1 1 2 2 2 0 TRL-like protein family Dimer_Tnp_hAT PF05699.14 EFA75372.1 - 1.5e-10 40.7 0.3 5.5e-10 38.9 0.3 2.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pet127 PF08634.10 EFA75373.1 - 0.03 13.8 0.9 0.031 13.7 0.9 1.0 1 0 0 1 1 1 0 Mitochondrial protein Pet127 Nop14 PF04147.12 EFA75374.1 - 0.019 13.2 13.8 0.026 12.8 13.8 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EFA75374.1 - 0.044 13.2 14.6 0.062 12.7 14.6 1.1 1 0 0 1 1 1 0 SDA1 FSA_C PF10479.9 EFA75374.1 - 0.082 11.0 16.9 0.11 10.6 16.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus BUD22 PF09073.10 EFA75374.1 - 0.086 12.2 15.8 0.12 11.7 15.8 1.2 1 0 0 1 1 1 0 BUD22 EVI2A PF05399.11 EFA75374.1 - 0.2 11.2 15.4 1.3 8.5 16.2 1.9 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Ecl1 PF12855.7 EFA75374.1 - 0.65 11.1 27.9 1.2 10.2 27.9 1.3 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins BSP_II PF05432.11 EFA75374.1 - 1.5 8.4 25.1 3 7.5 25.1 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Cyto_heme_lyase PF01265.17 EFA75376.1 - 8.6e-12 45.2 0.8 1.5e-11 44.4 0.0 1.7 2 0 0 2 2 2 1 Cytochrome c/c1 heme lyase TUDOR PF00567.24 EFA75376.1 - 0.039 14.0 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Tudor domain Agenet PF05641.12 EFA75376.1 - 0.14 12.6 0.0 0.33 11.5 0.0 1.6 1 0 0 1 1 1 0 Agenet domain SOG2 PF10428.9 EFA75376.1 - 6.8 5.8 10.9 9.6 5.3 10.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Agenet PF05641.12 EFA75378.1 - 0.0094 16.4 0.2 0.42 11.1 0.0 2.5 2 0 0 2 2 2 1 Agenet domain TUDOR PF00567.24 EFA75378.1 - 0.23 11.5 3.2 0.55 10.3 0.0 2.6 3 0 0 3 3 3 0 Tudor domain DUF1388 PF07142.12 EFA75378.1 - 0.61 10.1 5.7 5.9 6.9 1.1 2.5 2 0 0 2 2 2 0 Repeat of unknown function (DUF1388) Ank_2 PF12796.7 EFA75380.1 - 0.0049 17.4 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75380.1 - 0.012 15.9 1.6 0.076 13.4 0.0 2.8 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75380.1 - 0.19 12.3 0.0 1.9 9.2 0.0 2.3 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA75380.1 - 1.5 8.8 8.0 0.29 11.1 1.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA75381.1 - 1.2e-22 80.3 5.9 2.5e-07 31.2 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75381.1 - 1.3e-19 70.3 8.7 1.1e-05 25.9 0.0 6.4 5 2 0 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75381.1 - 2.2e-18 66.0 3.1 0.013 15.8 0.0 7.3 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75381.1 - 1.8e-09 37.0 4.0 19 6.3 0.0 8.8 9 2 2 11 11 11 0 Ankyrin repeat DUF5049 PF16468.5 EFA75381.1 - 1.5e-05 24.8 0.1 1.9 8.4 0.1 5.4 2 1 4 6 6 6 1 Domain of unknown function (DUF5049) UTP15_C PF09384.10 EFA75381.1 - 0.0014 18.3 0.1 0.032 13.9 0.0 2.4 2 0 0 2 2 2 1 UTP15 C terminal UPF0489 PF12640.7 EFA75381.1 - 0.0053 17.0 3.4 20 5.3 0.0 4.1 2 1 2 4 4 4 0 UPF0489 domain Ank PF00023.30 EFA75381.1 - 0.014 15.8 0.2 93 3.7 0.1 5.5 3 2 1 4 4 4 0 Ankyrin repeat APOBEC3 PF18771.1 EFA75381.1 - 0.023 14.8 1.4 7.2 6.7 0.0 3.6 1 1 2 4 4 4 0 APOBEC3 Lipin_N PF04571.14 EFA75381.1 - 0.089 12.8 0.0 12 5.9 0.0 2.5 1 1 0 2 2 2 0 lipin, N-terminal conserved region zf-TRAF PF02176.18 EFA75381.1 - 0.68 10.7 3.3 1 10.1 0.1 2.6 2 1 0 2 2 2 0 TRAF-type zinc finger Ank_2 PF12796.7 EFA75382.1 - 4.8e-05 23.9 0.0 0.00011 22.8 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75382.1 - 6.5e-05 23.4 0.1 0.00023 21.7 0.0 2.0 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75382.1 - 0.0012 19.1 0.2 0.33 11.7 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFA75382.1 - 0.006 16.9 0.1 4.3 7.8 0.0 2.3 1 1 0 2 2 2 2 Ankyrin repeats (many copies) CoA_trans PF01144.23 EFA75383.1 - 1.8e-114 380.6 1.9 2.2e-74 249.5 0.3 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 EFA75383.1 - 0.039 13.9 0.1 0.31 11.0 0.0 2.1 2 0 0 2 2 2 0 Acetyl-CoA hydrolase/transferase C-terminal domain COX17 PF05051.13 EFA75384.1 - 1.1e-19 70.5 8.3 1.2e-19 70.3 8.3 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) adh_short PF00106.25 EFA75385.1 - 1e-47 162.2 0.1 1.3e-47 161.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA75385.1 - 1e-31 110.3 0.0 1.4e-31 109.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA75385.1 - 3.4e-09 36.9 0.0 6.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA75385.1 - 0.0019 17.7 0.0 0.0035 16.9 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA75385.1 - 0.0078 16.1 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EFA75385.1 - 0.01 15.2 0.1 0.088 12.2 0.1 2.3 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EFA75385.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family RmlD_sub_bind PF04321.17 EFA75385.1 - 0.051 12.7 0.0 0.077 12.1 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Cation_efflux PF01545.21 EFA75386.1 - 3e-36 125.0 18.0 1.1e-35 123.2 18.0 1.8 1 1 0 1 1 1 1 Cation efflux family VWA PF00092.28 EFA75387.1 - 1.6e-15 57.8 0.7 4.8e-15 56.2 0.7 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA75387.1 - 1.8e-07 31.7 0.0 7.6e-07 29.8 0.0 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain DUF1065 PF06358.11 EFA75387.1 - 0.038 13.9 0.0 0.093 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1065) DUF1329 PF07044.11 EFA75387.1 - 0.072 12.4 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1329) Ras PF00071.22 EFA75388.1 - 1.4e-57 193.8 0.3 1.8e-57 193.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75388.1 - 2e-32 111.9 0.1 8.6e-32 109.9 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75388.1 - 2.2e-12 46.8 0.1 3.4e-12 46.2 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA75388.1 - 2.7e-06 27.4 0.0 8e-06 25.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA75388.1 - 5.1e-05 22.9 0.2 0.00013 21.6 0.1 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA75388.1 - 0.00027 20.4 1.3 0.0005 19.5 0.1 1.8 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region ATPase_2 PF01637.18 EFA75388.1 - 0.005 16.8 1.1 0.06 13.2 0.0 2.0 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EFA75388.1 - 0.016 15.8 0.6 0.054 14.1 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFA75388.1 - 0.018 15.1 0.1 0.14 12.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain UPF0270 PF06794.12 EFA75388.1 - 0.022 14.8 0.2 0.041 14.0 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) Hexose_dehydrat PF03559.14 EFA75388.1 - 0.048 13.1 0.1 0.066 12.6 0.1 1.2 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase AAA_28 PF13521.6 EFA75388.1 - 0.082 13.2 0.0 0.95 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA75388.1 - 0.088 13.2 0.0 0.15 12.5 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain LuxT_C PF18285.1 EFA75388.1 - 0.096 13.2 0.0 0.35 11.4 0.0 1.9 2 0 0 2 2 2 0 Tetracycline repressor LuxT C-terminal domain AAA PF00004.29 EFA75388.1 - 0.099 13.1 0.6 1.7 9.1 0.3 2.6 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cgr1 PF03879.14 EFA75389.1 - 1.4e-09 38.3 26.8 1.4e-09 38.3 26.8 2.4 2 1 1 3 3 3 1 Cgr1 family Ank_2 PF12796.7 EFA75390.1 - 1.6e-38 131.2 14.9 1e-08 35.7 0.2 8.5 2 1 2 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75390.1 - 1.9e-33 114.4 19.2 1.1e-05 25.9 0.1 12.3 6 4 7 13 13 13 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75390.1 - 6.2e-30 102.9 15.2 0.061 13.7 0.0 15.0 5 2 11 17 17 17 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75390.1 - 7.2e-29 96.6 8.9 0.01 16.3 0.0 16.9 18 1 1 19 19 19 5 Ankyrin repeat DUF5049 PF16468.5 EFA75390.1 - 1.2e-06 28.3 5.0 2.2 8.2 0.0 9.3 12 2 2 14 14 14 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA75390.1 - 0.00014 22.1 0.5 17 6.1 0.0 5.8 5 2 0 5 5 5 1 Ankyrin repeat SF3a60_bindingd PF12108.8 EFA75390.1 - 0.56 10.1 3.2 1.1 9.2 3.2 1.4 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain FBD PF08387.10 EFA75390.1 - 4.5 7.2 11.8 59 3.7 0.1 6.2 8 2 0 8 8 8 0 FBD TPR_1 PF00515.28 EFA75391.1 - 7e-05 22.5 0.1 0.00015 21.4 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75391.1 - 0.00028 20.8 0.0 0.00064 19.7 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3439 PF11921.8 EFA75391.1 - 0.37 10.8 6.4 2.4 8.1 6.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) RabGAP-TBC PF00566.18 EFA75392.1 - 1.9e-41 142.1 6.0 1.9e-41 142.1 6.0 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain TFIIA PF03153.13 EFA75393.1 - 0.00052 20.1 41.6 0.00084 19.5 41.6 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.11 EFA75393.1 - 0.82 7.7 15.1 0.61 8.1 0.1 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Aminotran_1_2 PF00155.21 EFA75395.1 - 5e-90 302.3 0.0 6.8e-90 301.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Pur_ac_phosph_N PF16656.5 EFA75395.1 - 3.6e-11 43.5 0.1 1.3e-10 41.7 0.1 2.0 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EFA75395.1 - 3e-05 24.6 0.0 0.0001 22.9 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase IBR PF01485.21 EFA75396.1 - 4.4e-08 33.2 8.1 4.4e-08 33.2 8.1 4.0 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFA75396.1 - 0.0045 17.3 10.1 0.0045 17.3 10.1 4.0 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 EFA75396.1 - 0.016 15.2 9.9 0.016 15.2 9.9 4.2 2 1 1 3 3 3 0 zinc-RING finger domain Prefoldin_2 PF01920.20 EFA75396.1 - 0.046 13.7 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Prefoldin subunit Ubiq_cyt_C_chap PF03981.12 EFA75397.1 - 2.6e-31 108.6 0.2 4.2e-31 107.9 0.2 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Fe_bilin_red PF05996.12 EFA75397.1 - 0.024 14.3 0.9 0.048 13.3 0.9 1.5 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase DUF4473 PF14747.6 EFA75397.1 - 0.048 14.2 2.0 0.14 12.8 2.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) RNA_pol_Rpb5_C PF01191.19 EFA75397.1 - 0.06 13.2 2.2 0.096 12.6 1.3 1.9 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Ada3 PF10198.9 EFA75397.1 - 0.19 11.9 5.7 0.31 11.2 5.7 1.3 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 SHQ1 PF04925.15 EFA75398.1 - 4.4e-41 140.4 5.6 9.4e-23 80.7 0.1 2.5 1 1 1 2 2 2 2 SHQ1 protein Copine PF07002.16 EFA75399.1 - 1.1e-51 175.3 0.0 1.9e-51 174.6 0.0 1.4 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFA75399.1 - 2.5e-21 75.9 0.4 2.3e-11 43.9 0.1 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFA75399.1 - 8.7e-08 32.5 0.0 2.1e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 vWA found in TerF C terminus Pkinase_Tyr PF07714.17 EFA75400.1 - 1.1e-56 192.0 0.0 1.7e-56 191.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75400.1 - 2.6e-55 187.7 0.0 4.7e-55 186.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RasGEF PF00617.19 EFA75400.1 - 2.1e-42 145.3 0.0 5.7e-42 143.9 0.0 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA75400.1 - 2.6e-18 66.2 3.9 5.9e-18 65.0 0.2 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif Haspin_kinase PF12330.8 EFA75400.1 - 2.9e-06 26.5 0.1 6.5e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFA75400.1 - 0.0049 16.2 0.1 0.0098 15.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA75400.1 - 0.025 14.5 0.0 0.085 12.8 0.0 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA75400.1 - 0.033 13.0 2.0 0.036 12.8 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 EFA75400.1 - 0.034 13.5 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EFA75400.1 - 0.076 12.6 1.9 0.13 11.8 0.0 2.2 3 0 0 3 3 3 0 Choline/ethanolamine kinase Phasin_2 PF09361.10 EFA75400.1 - 0.18 12.1 0.1 0.78 10.0 0.1 2.1 1 0 0 1 1 1 0 Phasin protein Menin PF05053.13 EFA75400.1 - 0.72 8.2 6.0 1.1 7.6 6.0 1.1 1 0 0 1 1 1 0 Menin Med4 PF10018.9 EFA75401.1 - 1.3e-27 96.7 4.0 1.3e-27 96.7 4.0 2.1 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 TFIIA PF03153.13 EFA75401.1 - 1.2e-06 28.8 17.6 1.6e-06 28.4 17.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MAP65_ASE1 PF03999.12 EFA75401.1 - 0.033 12.9 20.9 0.042 12.5 20.9 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Arb1 PF09692.10 EFA75401.1 - 0.22 10.7 5.1 0.3 10.2 5.1 1.1 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 FAM76 PF16046.5 EFA75401.1 - 1.1 8.6 12.5 1.5 8.1 12.5 1.1 1 0 0 1 1 1 0 FAM76 protein FNIP PF05725.12 EFA75402.1 - 1.4e-13 50.7 40.2 2.3e-05 24.4 0.1 10.1 6 1 5 11 11 11 8 FNIP Repeat F-box_5 PF18511.1 EFA75402.1 - 0.00051 19.5 0.2 0.00099 18.6 0.2 1.4 1 0 0 1 1 1 1 F-box 5-FTHF_cyc-lig PF01812.20 EFA75403.1 - 0.019 14.8 1.3 0.023 14.6 1.3 1.2 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family ThiG PF05690.14 EFA75403.1 - 0.093 12.0 1.2 0.11 11.8 1.2 1.1 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG FNIP PF05725.12 EFA75405.1 - 7.2e-11 42.1 38.0 2.4e-06 27.6 0.2 9.2 5 2 5 10 10 10 7 FNIP Repeat F-box_5 PF18511.1 EFA75405.1 - 0.0006 19.3 0.2 0.0012 18.4 0.2 1.4 1 0 0 1 1 1 1 F-box GATase_5 PF13507.6 EFA75406.1 - 3.8e-102 340.8 0.0 6.9e-102 340.0 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EFA75406.1 - 7.3e-29 100.9 0.6 6e-17 62.2 0.6 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EFA75406.1 - 1.1e-19 70.5 0.3 2.5e-19 69.4 0.3 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EFA75406.1 - 1.8e-10 41.2 0.0 7.8e-10 39.1 0.1 2.1 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 EFA75406.1 - 0.0091 16.6 0.1 0.16 12.6 0.0 2.9 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain DUF1604 PF07713.13 EFA75406.1 - 0.39 10.5 1.4 0.82 9.5 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1604) MSP7_C PF12948.7 EFA75407.1 - 0.053 14.2 6.1 0.075 13.7 6.1 1.3 1 0 0 1 1 1 0 MSP7-like protein C-terminal domain Vault_2 PF17794.1 EFA75407.1 - 0.085 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Major Vault Protein repeat domain Sds3 PF08598.11 EFA75408.1 - 0.0075 16.3 15.1 0.0075 16.3 15.1 1.3 1 1 0 1 1 1 1 Sds3-like Mac-1 PF09028.10 EFA75408.1 - 0.016 14.3 5.3 0.019 14.1 5.3 1.1 1 0 0 1 1 1 0 Mac 1 DUF4482 PF14818.6 EFA75408.1 - 0.033 15.1 5.5 0.033 15.1 5.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) HGD-D PF06050.13 EFA75408.1 - 0.1 12.3 1.9 0.11 12.3 1.9 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component DUF836 PF05768.14 EFA75408.1 - 0.26 11.7 3.8 0.59 10.6 2.0 2.0 1 1 1 2 2 2 0 Glutaredoxin-like domain (DUF836) CREPT PF16566.5 EFA75408.1 - 0.49 10.6 8.9 1.2 9.3 8.4 1.9 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour MAM33 PF02330.16 EFA75409.1 - 1e-11 45.2 17.6 1.1e-09 38.6 17.6 2.9 1 1 0 1 1 1 1 Mitochondrial glycoprotein FmiP_Thoc5 PF09766.9 EFA75409.1 - 0.016 14.5 0.7 0.021 14.1 0.7 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Nop14 PF04147.12 EFA75409.1 - 1.8 6.7 19.9 2.3 6.3 19.9 1.1 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 EFA75409.1 - 2.8 7.3 16.9 4.1 6.7 16.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Roughex PF06020.11 EFA75409.1 - 3.2 6.8 10.8 4.7 6.2 10.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF2457 PF10446.9 EFA75409.1 - 4.4 6.3 18.0 6.1 5.9 18.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 EFA75409.1 - 8 5.8 16.7 10 5.4 16.7 1.1 1 0 0 1 1 1 0 SDA1 VWA PF00092.28 EFA75410.1 - 2e-07 31.4 1.9 4.2e-07 30.4 1.9 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Big_9 PF17963.1 EFA75410.1 - 9e-05 23.1 32.3 0.0014 19.3 2.0 7.1 6 0 0 6 6 6 2 Bacterial Ig domain Cadherin_5 PF17892.1 EFA75410.1 - 0.00085 19.3 0.1 0.00085 19.3 0.1 3.6 3 0 0 3 3 3 1 Cadherin-like domain Cadherin_3 PF16184.5 EFA75410.1 - 0.016 15.2 0.7 7 6.7 0.0 3.2 3 0 0 3 3 3 0 Cadherin-like Integrin_beta PF00362.18 EFA75410.1 - 0.061 13.0 0.1 0.85 9.2 0.0 2.2 2 0 0 2 2 2 0 Integrin beta chain VWA domain Glyco_transf_21 PF13506.6 EFA75410.1 - 0.14 11.6 0.0 0.37 10.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 21 Laminin_EGF PF00053.24 EFA75410.1 - 9 6.5 19.8 12 6.1 4.8 2.6 1 1 1 2 2 2 0 Laminin EGF domain PKD PF00801.20 EFA75411.1 - 2e-05 24.4 6.7 0.0024 17.7 0.1 4.5 4 0 0 4 4 4 1 PKD domain Big_9 PF17963.1 EFA75411.1 - 5.4e-05 23.8 24.1 0.00041 21.0 2.4 6.7 5 0 0 5 5 5 2 Bacterial Ig domain Integrin_b_cyt PF08725.11 EFA75411.1 - 0.085 12.6 0.1 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Integrin beta cytoplasmic domain Cadherin_3 PF16184.5 EFA75411.1 - 0.2 11.7 1.0 4.5 7.3 0.0 3.0 3 0 0 3 3 3 0 Cadherin-like Cadherin_5 PF17892.1 EFA75411.1 - 6.4 6.8 7.0 2.4 8.2 0.1 3.9 5 0 0 5 5 5 0 Cadherin-like domain TH1 PF04858.13 EFA75412.1 - 1.8e-150 502.4 4.8 2.4e-150 502.0 4.8 1.0 1 0 0 1 1 1 1 TH1 protein ATG27 PF09451.10 EFA75412.1 - 1.5e-09 38.1 0.3 8.7e-09 35.6 0.3 2.0 1 1 0 1 1 1 1 Autophagy-related protein 27 PRKCSH_1 PF13015.6 EFA75412.1 - 0.0031 17.2 0.0 0.0078 15.9 0.0 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein BORCS6 PF10157.9 EFA75412.1 - 2.6 8.3 6.6 3.5 7.8 2.1 2.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 AAA_12 PF13087.6 EFA75413.1 - 1.8e-47 161.6 0.6 1.8e-47 161.6 0.6 3.5 3 0 0 3 3 3 1 AAA domain FNIP PF05725.12 EFA75413.1 - 3.7e-16 59.0 20.4 4.3e-07 30.0 1.0 7.6 4 2 2 6 6 6 5 FNIP Repeat DUF2439 PF10382.9 EFA75413.1 - 4.2e-15 55.9 0.6 4.2e-15 55.9 0.6 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) Viral_helicase1 PF01443.18 EFA75413.1 - 1.5e-07 31.4 1.1 0.013 15.3 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase zf-GRF PF06839.12 EFA75413.1 - 1.7e-07 31.2 1.9 3.9e-07 30.0 1.9 1.6 1 0 0 1 1 1 1 GRF zinc finger UvrD_C_2 PF13538.6 EFA75413.1 - 0.00027 20.7 0.0 0.00056 19.7 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain F-box_5 PF18511.1 EFA75413.1 - 0.13 11.9 0.1 0.31 10.7 0.1 1.5 1 0 0 1 1 1 0 F-box FNIP PF05725.12 EFA75414.1 - 9e-16 57.8 29.7 7.5e-07 29.2 1.1 7.6 5 1 4 9 9 9 6 FNIP Repeat Big_9 PF17963.1 EFA75414.1 - 7e-06 26.7 84.9 8.3e-06 26.5 0.4 11.1 10 2 0 10 10 10 4 Bacterial Ig domain Laminin_EGF PF00053.24 EFA75414.1 - 0.0017 18.4 14.0 0.0082 16.3 6.6 2.6 1 1 1 2 2 2 1 Laminin EGF domain F-box_5 PF18511.1 EFA75414.1 - 0.0019 17.7 0.1 0.0043 16.6 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75414.1 - 0.012 15.5 1.9 0.03 14.2 1.5 2.0 2 0 0 2 2 2 0 F-box-like hEGF PF12661.7 EFA75414.1 - 0.06 14.0 17.5 0.24 12.1 5.6 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFA75414.1 - 0.32 11.1 5.5 0.79 9.8 5.5 1.6 1 0 0 1 1 1 0 Tenascin EGF domain Cadherin_5 PF17892.1 EFA75414.1 - 0.45 10.5 17.9 1.6 8.8 0.3 6.2 5 1 0 5 5 5 0 Cadherin-like domain EGF_2 PF07974.13 EFA75414.1 - 1.6 9.2 25.9 0.31 11.4 5.6 3.5 3 0 0 3 3 3 0 EGF-like domain Cadherin_4 PF17803.1 EFA75414.1 - 5.1 7.8 57.1 0.02 15.5 2.0 9.1 8 1 0 8 8 7 0 Bacterial cadherin-like domain DSL PF01414.19 EFA75414.1 - 9.2 6.6 14.7 3.3 8.0 4.5 2.7 2 0 0 2 2 2 0 Delta serrate ligand FNIP PF05725.12 EFA75415.1 - 1.8e-10 40.8 4.1 2.3e-05 24.5 0.5 3.3 2 1 1 3 3 3 3 FNIP Repeat FNIP PF05725.12 EFA75416.1 - 2.1e-08 34.2 8.1 0.0026 17.9 0.1 4.1 3 2 0 3 3 3 2 FNIP Repeat Taxilin PF09728.9 EFA75417.1 - 6e-57 193.2 60.2 6e-57 193.2 60.2 2.8 1 1 0 2 2 2 1 Myosin-like coiled-coil protein DUF4164 PF13747.6 EFA75417.1 - 0.00012 22.3 1.7 0.00012 22.3 1.7 4.7 2 1 2 4 4 4 2 Domain of unknown function (DUF4164) Strep_SA_rep PF06696.11 EFA75417.1 - 3.7 7.7 8.9 90 3.3 0.1 5.0 5 0 0 5 5 5 0 Streptococcal surface antigen repeat Ank_2 PF12796.7 EFA75418.1 - 2.2e-37 127.5 5.8 1.8e-09 38.1 0.0 7.4 4 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75418.1 - 1.1e-35 121.6 7.9 1.2e-05 25.7 0.0 9.3 7 2 1 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75418.1 - 2.3e-28 97.9 12.8 0.011 16.0 0.0 13.4 5 4 9 15 15 15 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75418.1 - 3.6e-26 88.4 1.6 0.032 14.8 0.0 14.2 15 0 0 15 15 14 4 Ankyrin repeat F5_F8_type_C PF00754.25 EFA75418.1 - 1.6e-20 73.5 2.7 4.6e-20 72.0 2.7 1.8 1 0 0 1 1 1 1 F5/8 type C domain H_lectin PF09458.10 EFA75418.1 - 1.9e-13 50.3 0.1 6.1e-13 48.8 0.1 1.9 1 0 0 1 1 1 1 H-type lectin domain Helicase_PWI PF18149.1 EFA75418.1 - 5.6e-06 26.5 0.5 0.0014 18.8 0.0 4.1 2 1 3 5 5 5 1 N-terminal helicase PWI domain DUF3447 PF11929.8 EFA75418.1 - 7.6e-06 25.8 17.0 8.1 6.5 0.0 8.1 4 2 1 7 7 7 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA75418.1 - 0.00012 22.4 0.0 1.2e+02 3.4 0.0 6.9 7 0 0 7 7 7 0 Ankyrin repeat DEP PF00610.21 EFA75418.1 - 0.23 11.5 3.5 17 5.5 0.1 4.6 4 1 1 5 5 5 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF249 PF03158.13 EFA75418.1 - 1.5 8.5 9.5 17 5.0 0.1 4.9 2 1 3 6 6 6 0 Multigene family 530 protein Ank_4 PF13637.6 EFA75420.1 - 0.00027 21.4 0.0 0.31 11.7 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75420.1 - 0.0022 18.3 0.0 1.5 9.6 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat SP24 PF16504.5 EFA75420.1 - 0.0077 16.3 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 Putative virion membrane protein of plant and insect virus Ank_2 PF12796.7 EFA75420.1 - 0.011 16.3 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) NUDIX PF00293.28 EFA75421.1 - 5.4e-05 23.2 0.0 0.0005 20.1 0.0 2.4 1 1 0 1 1 1 1 NUDIX domain DUF759 PF05537.11 EFA75421.1 - 0.19 10.6 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF759) Acetyltransf_1 PF00583.25 EFA75422.1 - 1.7e-11 44.3 0.0 2.3e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA75422.1 - 1.9e-08 34.6 0.0 2.8e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA75422.1 - 2.4e-06 27.5 0.0 4.8e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFA75422.1 - 0.0068 15.9 0.3 0.0092 15.5 0.3 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 EFA75422.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA75422.1 - 0.028 14.4 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein DUF1040 PF06288.13 EFA75422.1 - 0.09 13.2 0.7 0.2 12.1 0.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1040) Sec8_exocyst PF04048.14 EFA75423.1 - 0.019 14.9 0.8 0.048 13.5 0.8 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Nyv1_N PF09426.10 EFA75423.1 - 0.052 13.6 0.1 1 9.4 0.0 2.7 2 0 0 2 2 2 0 Vacuolar R-SNARE Nyv1 N terminal Kinesin_assoc PF16183.5 EFA75423.1 - 0.28 11.3 7.5 6 7.0 0.2 3.7 4 0 0 4 4 4 0 Kinesin-associated Myb_DNA-bind_6 PF13921.6 EFA75424.1 - 0.1 12.8 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF2368 PF10166.9 EFA75424.1 - 0.17 11.5 3.0 6.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) PAP2_3 PF14378.6 EFA75425.1 - 1.4e-15 57.5 1.8 1.4e-15 57.5 1.8 4.0 4 1 0 5 5 5 1 PAP2 superfamily PAP2 PF01569.21 EFA75425.1 - 2.7e-08 33.7 4.6 2.7e-08 33.7 4.6 3.8 2 1 1 3 3 3 1 PAP2 superfamily Lipase_3 PF01764.25 EFA75426.1 - 5.8e-23 81.3 0.7 2.3e-22 79.4 0.0 2.3 3 0 0 3 3 3 1 Lipase (class 3) DUF1350 PF07082.11 EFA75426.1 - 0.028 13.7 0.0 0.068 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) Hydrolase_4 PF12146.8 EFA75426.1 - 0.054 12.8 0.0 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 RNA_pol_Rpb8 PF03870.15 EFA75427.1 - 1.4e-47 161.4 0.1 1.5e-47 161.3 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EFA75427.1 - 6e-06 26.3 0.1 0.00012 22.1 0.1 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G Hexapep PF00132.24 EFA75428.1 - 1e-11 44.0 9.2 1.4e-05 24.6 0.0 4.2 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFA75428.1 - 0.00015 21.5 9.8 0.00023 20.8 2.7 3.0 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EFA75428.1 - 0.017 14.1 0.2 0.098 11.6 0.1 1.9 2 0 0 2 2 2 0 L-fucokinase DUF4954 PF16314.5 EFA75428.1 - 0.51 8.4 3.9 0.11 10.6 0.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4954) fn3 PF00041.21 EFA75429.1 - 3e-18 65.9 36.0 0.00016 22.0 0.5 10.1 10 0 0 10 10 10 5 Fibronectin type III domain DUF2369 PF10179.9 EFA75429.1 - 1.5e-05 25.3 19.4 0.034 14.5 0.1 6.6 5 1 2 7 7 7 2 Uncharacterised conserved protein (DUF2369) EGF_2 PF07974.13 EFA75429.1 - 0.00057 20.2 12.2 0.00057 20.2 12.2 2.2 2 0 0 2 2 2 1 EGF-like domain Pur_ac_phosph_N PF16656.5 EFA75429.1 - 0.048 14.2 35.5 0.075 13.6 1.0 7.2 4 2 1 5 5 5 0 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 EFA75429.1 - 0.063 13.1 24.1 4.5 7.2 0.2 7.1 3 3 4 7 7 7 0 Tissue factor I-EGF_1 PF18372.1 EFA75429.1 - 0.07 13.2 9.8 0.28 11.3 9.8 2.2 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF PF00008.27 EFA75429.1 - 1.3 9.4 11.7 0.24 11.8 7.0 2.3 2 0 0 2 2 2 0 EGF-like domain fn3 PF00041.21 EFA75430.1 - 3.5e-17 62.5 39.6 0.00016 21.9 0.5 10.3 10 0 0 10 10 10 6 Fibronectin type III domain DUF2369 PF10179.9 EFA75430.1 - 7.3e-07 29.5 18.7 0.034 14.5 0.1 7.0 6 0 0 6 6 6 2 Uncharacterised conserved protein (DUF2369) Tissue_fac PF01108.17 EFA75430.1 - 0.00056 19.7 23.5 0.56 10.1 0.0 7.8 6 2 1 7 7 7 3 Tissue factor EGF_2 PF07974.13 EFA75430.1 - 0.00058 20.2 12.2 0.00058 20.2 12.2 2.2 2 0 0 2 2 2 1 EGF-like domain Pur_ac_phosph_N PF16656.5 EFA75430.1 - 0.033 14.8 36.9 0.076 13.6 1.0 7.7 6 3 0 6 6 6 0 Purple acid Phosphatase, N-terminal domain I-EGF_1 PF18372.1 EFA75430.1 - 0.054 13.6 9.8 0.28 11.3 9.8 2.4 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF PF00008.27 EFA75430.1 - 1.3 9.4 11.7 0.24 11.7 7.0 2.3 2 0 0 2 2 2 0 EGF-like domain DUF3042 PF11240.8 EFA75431.1 - 0.7 10.0 3.0 1.5 8.9 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) ETF PF01012.21 EFA75433.1 - 8.5e-44 149.6 1.3 1e-43 149.3 1.3 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain TPP_enzyme_M PF00205.22 EFA75433.1 - 0.017 14.8 0.1 0.036 13.8 0.1 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Ribosomal_L6 PF00347.23 EFA75433.1 - 0.84 10.3 6.5 0.38 11.5 0.4 3.1 3 0 0 3 3 3 0 Ribosomal protein L6 Dynamin_M PF01031.20 EFA75434.1 - 2.5e-103 345.2 0.1 2.5e-103 345.2 0.1 3.6 4 0 0 4 4 4 1 Dynamin central region Dynamin_N PF00350.23 EFA75434.1 - 5.2e-59 199.1 0.0 5.2e-59 199.1 0.0 5.3 5 0 0 5 5 5 1 Dynamin family RhoGEF PF00621.20 EFA75434.1 - 1.2e-41 142.9 6.1 1.2e-41 142.9 6.1 4.8 4 1 0 4 4 4 1 RhoGEF domain GED PF02212.18 EFA75434.1 - 1.5e-32 111.6 3.2 5.3e-32 109.8 3.2 2.1 1 0 0 1 1 1 1 Dynamin GTPase effector domain CH PF00307.31 EFA75434.1 - 2.3e-11 43.9 2.5 1.7e-10 41.1 0.0 3.4 3 0 0 3 3 3 1 Calponin homology (CH) domain PH PF00169.29 EFA75434.1 - 0.016 15.7 0.0 0.073 13.6 0.0 2.3 1 0 0 1 1 1 0 PH domain CAMSAP_CH PF11971.8 EFA75434.1 - 0.039 13.8 0.0 0.38 10.6 0.0 2.6 2 0 0 2 2 2 0 CAMSAP CH domain IQ PF00612.27 EFA75434.1 - 0.58 10.1 5.9 1.4 8.9 5.9 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif CBM49 PF09478.10 EFA75435.1 - 1.1e-16 60.9 0.3 2.8e-16 59.6 0.3 1.6 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 PRR18 PF15671.5 EFA75435.1 - 9.1 6.1 8.3 14 5.5 8.3 1.2 1 0 0 1 1 1 0 Proline-rich protein family 18 HEPN_RnaseLS PF18869.1 EFA75436.1 - 0.017 15.3 0.1 0.04 14.0 0.1 1.6 1 0 0 1 1 1 0 RnaseLS-like HEPN Nbas_N PF15492.6 EFA75437.1 - 0.0015 18.0 0.1 0.01 15.2 0.1 2.2 1 1 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal ANAPC4_WD40 PF12894.7 EFA75437.1 - 0.08 13.3 0.0 8.7 6.7 0.0 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain GpcrRhopsn4 PF10192.9 EFA75438.1 - 1.6e-13 50.7 24.6 3e-13 49.8 24.6 1.5 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain TIG PF01833.24 EFA75439.1 - 1.4e-13 50.7 71.0 3e-06 27.2 0.9 9.1 8 1 1 9 9 9 5 IPT/TIG domain EGF_2 PF07974.13 EFA75439.1 - 0.023 15.0 12.0 0.052 13.9 12.0 1.6 1 0 0 1 1 1 0 EGF-like domain SNase PF00565.17 EFA75440.1 - 5.1e-50 168.5 1.8 7.6e-14 52.1 0.1 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EFA75440.1 - 5.8e-21 74.8 0.0 1.3e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EFA75440.1 - 0.0018 17.6 0.1 0.0018 17.6 0.1 2.0 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) Agenet PF05641.12 EFA75440.1 - 0.036 14.5 0.0 0.17 12.4 0.0 2.2 1 0 0 1 1 1 0 Agenet domain PH PF00169.29 EFA75441.1 - 4.7e-14 52.8 0.3 4.7e-14 52.8 0.3 2.8 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA75441.1 - 3e-06 27.4 2.7 3.3e-06 27.3 0.2 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EFA75441.1 - 2e-05 25.0 1.2 2e-05 25.0 1.2 4.6 2 2 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EFA75441.1 - 8e-05 22.7 0.2 0.00027 21.0 0.2 1.9 1 0 0 1 1 1 1 PH domain Adap_comp_sub PF00928.21 EFA75442.1 - 2.2e-18 66.6 1.1 3.7e-18 65.9 1.1 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFA75442.1 - 3.7e-06 26.9 0.2 7.3e-06 26.0 0.2 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain GRP PF07172.11 EFA75442.1 - 0.26 12.0 11.5 0.56 10.9 11.5 1.5 1 0 0 1 1 1 0 Glycine rich protein family WD40 PF00400.32 EFA75443.1 - 4.1e-34 116.0 17.4 7.9e-06 26.5 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EFA75443.1 - 1.4e-12 47.3 0.1 3.3e-12 46.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75443.1 - 1.1e-08 34.8 0.0 2.5e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EFA75443.1 - 3.7e-06 27.1 4.1 0.059 13.7 0.2 4.9 1 1 6 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA75443.1 - 1.8e-05 24.2 0.4 0.081 12.2 0.1 3.2 2 1 0 2 2 2 2 WD40-like domain F-box_4 PF15966.5 EFA75443.1 - 0.013 15.4 0.0 0.047 13.6 0.0 2.0 2 0 0 2 2 2 0 F-box Nup160 PF11715.8 EFA75443.1 - 0.023 13.3 11.7 4.9 5.7 0.0 4.9 2 2 3 5 5 5 0 Nucleoporin Nup120/160 DUF4838 PF16126.5 EFA75443.1 - 0.032 13.6 3.0 0.056 12.8 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) Methyltransf_8 PF05148.15 EFA75444.1 - 1.5e-75 253.8 0.7 2.3e-75 253.2 0.7 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EFA75444.1 - 5.7e-10 39.7 0.1 2.9e-09 37.5 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA75444.1 - 8e-07 29.0 0.4 0.00026 20.8 0.4 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA75444.1 - 1.3e-06 29.0 0.0 0.00011 22.9 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA75444.1 - 0.0063 16.1 4.7 0.07 12.7 0.0 2.9 2 1 1 3 3 3 2 Methyltransferase small domain Methyltransf_23 PF13489.6 EFA75444.1 - 0.029 14.2 0.0 0.076 12.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFA75444.1 - 0.13 12.3 0.0 0.13 12.3 0.0 3.0 3 1 0 3 3 3 0 Methyltransferase domain Histone PF00125.24 EFA75445.1 - 2.4e-10 40.9 0.4 5.1e-10 39.8 0.0 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EFA75445.1 - 1.1e-09 37.9 1.1 2.8e-09 36.5 1.1 1.8 1 1 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EFA75445.1 - 5e-08 33.1 0.0 9.9e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Parecho_VpG PF06344.11 EFA75445.1 - 0.79 10.5 3.7 7 7.5 2.0 2.8 2 0 0 2 2 2 0 Parechovirus Genome-linked protein HMG_box PF00505.19 EFA75446.1 - 2.4e-17 63.1 2.2 2.4e-17 63.1 2.2 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFA75446.1 - 2.5e-11 44.0 1.8 2.5e-11 44.0 1.8 2.1 2 0 0 2 2 2 1 HMG-box domain EPL1 PF10513.9 EFA75446.1 - 0.037 14.4 13.6 0.055 13.8 13.6 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like CDC45 PF02724.14 EFA75446.1 - 0.19 10.0 12.8 0.21 9.9 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PI3K_1B_p101 PF10486.9 EFA75446.1 - 0.23 9.2 11.4 0.26 9.0 11.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SEEEED PF14797.6 EFA75446.1 - 0.88 9.7 22.6 1.5 9.0 22.6 1.3 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Macoilin PF09726.9 EFA75446.1 - 0.98 7.9 17.0 1.1 7.8 17.0 1.0 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 EFA75446.1 - 1.3 7.6 9.9 1.5 7.4 9.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 EFA75446.1 - 2.1 5.3 14.4 2.4 5.2 14.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PTPRCAP PF15713.5 EFA75446.1 - 4.6 7.5 11.7 8.9 6.6 11.7 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF3807 PF12720.7 EFA75446.1 - 4.7 7.5 16.2 6.9 6.9 16.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SLC12 PF03522.15 EFA75446.1 - 6.1 5.8 14.4 7.3 5.5 14.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAP PF02037.27 EFA75447.1 - 1.7e-08 34.0 2.2 3.5e-08 33.0 2.2 1.6 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 EFA75447.1 - 0.018 14.9 6.2 5.8 6.8 0.3 4.0 4 1 0 4 4 4 0 Tho1/MOS11 C-terminal domain SWIB PF02201.18 EFA75447.1 - 0.081 12.8 0.7 0.19 11.7 0.7 1.5 1 0 0 1 1 1 0 SWIB/MDM2 domain HeH PF12949.7 EFA75447.1 - 0.085 12.6 0.8 0.21 11.3 0.8 1.7 1 0 0 1 1 1 0 HeH/LEM domain Macoilin PF09726.9 EFA75447.1 - 5.6 5.4 18.5 7 5.1 18.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF5549 PF17703.1 EFA75449.1 - 0.11 12.2 3.9 0.12 12.0 3.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5549) DNA_pol_viral_C PF00336.18 EFA75450.1 - 0.029 13.8 0.1 0.05 13.0 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain CPSF_A PF03178.15 EFA75450.1 - 0.03 13.6 0.1 0.039 13.3 0.1 1.2 1 0 0 1 1 1 0 CPSF A subunit region zf-RING_9 PF13901.6 EFA75452.1 - 2.6e-25 89.6 14.4 2.6e-25 89.6 14.4 2.5 3 0 0 3 3 3 1 Putative zinc-RING and/or ribbon RUN PF02759.19 EFA75452.1 - 7.3e-11 42.2 0.0 7.3e-11 42.2 0.0 2.8 3 0 0 3 3 3 1 RUN domain Ost5 PF05251.12 EFA75453.1 - 1.1e-21 76.9 7.1 1.3e-21 76.6 7.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 Phage_holin_3_3 PF16083.5 EFA75453.1 - 0.016 15.3 3.1 0.021 14.9 3.1 1.1 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III PEP_mutase PF13714.6 EFA75454.1 - 1.1e-53 182.1 1.8 1.3e-53 181.9 1.8 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EFA75454.1 - 3.9e-15 55.3 0.1 6.1e-15 54.7 0.1 1.2 1 0 0 1 1 1 1 Isocitrate lyase family ABC2_membrane_3 PF12698.7 EFA75455.1 - 0.0015 17.7 0.6 0.0017 17.6 0.6 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein Renin_r PF07850.14 EFA75455.1 - 0.0074 16.9 0.6 0.0099 16.5 0.6 1.4 1 0 0 1 1 1 1 Renin receptor-like protein Connexin PF00029.19 EFA75455.1 - 0.0078 16.0 0.9 0.0094 15.7 0.9 1.1 1 0 0 1 1 1 1 Connexin MscS_TM PF12794.7 EFA75455.1 - 0.02 13.8 0.1 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF3675 PF12428.8 EFA75455.1 - 0.021 15.4 0.1 0.026 15.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) Orf78 PF06024.12 EFA75455.1 - 0.022 15.0 10.3 0.057 13.7 10.3 1.7 1 1 0 1 1 1 0 Orf78 (ac78) Peptidase_M56 PF05569.11 EFA75455.1 - 0.025 13.8 0.4 0.029 13.6 0.4 1.0 1 0 0 1 1 1 0 BlaR1 peptidase M56 CrgA PF06781.12 EFA75455.1 - 0.033 14.2 0.3 0.051 13.6 0.3 1.4 1 1 0 1 1 1 0 Cell division protein CrgA CSG2 PF16965.5 EFA75455.1 - 0.16 10.9 2.6 0.19 10.6 2.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator YajC PF02699.15 EFA75455.1 - 0.19 11.6 0.2 0.19 11.6 0.2 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit CLN3 PF02487.17 EFA75455.1 - 0.21 10.6 1.8 0.26 10.3 1.8 1.0 1 0 0 1 1 1 0 CLN3 protein DUF4718 PF15842.5 EFA75455.1 - 0.67 9.7 7.4 0.43 10.3 5.6 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4718) LRRC37AB_C PF14914.6 EFA75455.1 - 0.78 9.6 10.7 1.2 9.0 9.1 1.9 1 1 1 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain LMBR1 PF04791.16 EFA75455.1 - 1.4 7.7 7.5 3.2 6.5 8.0 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 EFA75455.1 - 1.7 8.7 7.3 1.2 9.2 6.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Ac76 PF05814.11 EFA75455.1 - 3.1 7.9 7.4 0.45 10.6 0.4 2.3 2 1 1 3 3 3 0 Orf76 (Ac76) Tmemb_9 PF05434.11 EFA75455.1 - 5.2 7.0 12.5 5.7 6.8 0.1 2.2 2 0 0 2 2 2 0 TMEM9 ERCC3_RAD25_C PF16203.5 EFA75456.1 - 6.5e-118 392.4 1.1 6.5e-118 392.4 1.1 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EFA75456.1 - 1e-12 48.4 0.0 2.5e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFA75456.1 - 6.4e-12 45.8 0.2 2.3e-11 44.0 0.2 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFA75456.1 - 2.9e-07 29.5 0.0 1.4e-06 27.3 0.0 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C_3 PF13625.6 EFA75456.1 - 0.00034 20.8 0.0 0.00079 19.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ParD_antitoxin PF03693.14 EFA75456.1 - 0.13 12.6 0.1 0.34 11.4 0.1 1.6 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Sec10 PF07393.11 EFA75457.1 - 2.9e-102 343.3 31.7 1.8e-54 185.4 12.4 2.8 2 1 1 3 3 3 2 Exocyst complex component Sec10 UPF0029 PF01205.19 EFA75457.1 - 1.3e-23 83.3 0.0 3.8e-23 81.8 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EFA75457.1 - 3.8e-12 46.5 3.2 5.5e-12 46.0 0.4 2.9 3 0 0 3 3 3 1 RWD domain ArdA PF07275.11 EFA75457.1 - 0.012 16.2 2.4 1 9.9 0.2 2.7 2 0 0 2 2 2 0 Antirestriction protein (ArdA) DUF1664 PF07889.12 EFA75457.1 - 0.023 14.7 2.2 0.053 13.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) FAM70 PF14967.6 EFA75457.1 - 0.84 9.0 6.4 0.64 9.4 4.6 1.7 1 1 0 1 1 1 0 FAM70 protein WD40 PF00400.32 EFA75458.1 - 1.1e-17 64.1 9.8 4.8e-06 27.2 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75458.1 - 3.6e-07 30.4 0.1 0.0016 18.7 0.0 2.9 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_alt PF14077.6 EFA75458.1 - 0.015 15.1 1.0 0.039 13.8 1.0 1.6 1 0 0 1 1 1 0 Alternative WD40 repeat motif DMPK_coil PF08826.10 EFA75458.1 - 1.1 9.5 4.5 4.2 7.6 0.1 3.2 3 0 0 3 3 3 0 DMPK coiled coil domain like Thioredoxin PF00085.20 EFA75460.1 - 4.5e-10 39.4 0.1 4.8e-09 36.1 0.0 2.8 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EFA75460.1 - 0.0048 17.3 0.4 0.047 14.1 0.0 2.8 4 0 0 4 4 4 1 Thioredoxin-like domain Ank_2 PF12796.7 EFA75461.1 - 5.1e-34 116.7 5.5 5.7e-07 30.0 0.1 6.4 3 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75461.1 - 3e-25 88.0 5.0 0.012 15.9 0.0 10.9 4 2 8 12 12 12 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75461.1 - 3.5e-23 81.6 11.4 1.2e-05 25.7 0.1 9.4 7 4 2 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75461.1 - 8e-20 68.8 1.4 1.8 9.4 0.0 12.4 14 0 0 14 14 14 4 Ankyrin repeat DUF3447 PF11929.8 EFA75461.1 - 1.1e-06 28.5 12.1 0.00052 19.9 0.4 5.3 4 2 2 6 6 6 3 Domain of unknown function (DUF3447) ketoacyl-synt PF00109.26 EFA75463.1 - 2.1e-64 217.6 0.0 3.3e-64 216.9 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA75463.1 - 1.8e-44 152.6 0.0 2.9e-44 151.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFA75463.1 - 1.7e-31 109.5 0.0 4.2e-31 108.2 0.0 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EFA75463.1 - 5.6e-28 98.0 0.0 8.4e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 EFA75463.1 - 6.6e-19 68.5 0.0 2.5e-16 60.2 0.0 3.3 2 0 0 2 2 2 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EFA75463.1 - 6.1e-16 58.9 0.0 2.1e-15 57.1 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFA75463.1 - 1.7e-11 43.9 0.0 6.4e-11 42.1 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_23 PF13489.6 EFA75463.1 - 2.1e-10 40.7 0.0 4.5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ketoacyl-synt_C PF02801.22 EFA75463.1 - 1.4e-09 38.0 0.6 2.9e-09 37.0 0.6 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short_C2 PF13561.6 EFA75463.1 - 2.4e-07 30.5 0.0 5.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N_2 PF13602.6 EFA75463.1 - 2.5e-07 31.8 0.0 7e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 EFA75463.1 - 3.4e-07 30.2 0.0 1.4e-06 28.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA75463.1 - 2.1e-06 28.4 0.0 2.3e-05 25.0 0.0 3.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA75463.1 - 2.6e-06 28.0 0.0 2.2e-05 25.0 0.0 2.8 2 0 0 2 2 1 1 Methyltransferase domain ADH_N PF08240.12 EFA75463.1 - 2.7e-05 24.0 0.1 0.00013 21.8 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EFA75463.1 - 8.4e-05 22.9 0.2 0.00026 21.3 0.2 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 EFA75463.1 - 0.00077 19.2 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase Thiolase_N PF00108.23 EFA75463.1 - 0.0029 17.0 0.1 0.0061 16.0 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EFA75463.1 - 0.034 13.5 0.0 0.09 12.1 0.0 1.7 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family WD40 PF00400.32 EFA75464.1 - 9.2e-16 58.0 15.0 0.00024 21.8 0.2 6.2 7 0 0 7 7 6 3 WD domain, G-beta repeat zf-RING_UBOX PF13445.6 EFA75464.1 - 3.6e-09 36.5 4.4 3.6e-09 36.5 4.4 2.7 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFA75464.1 - 1.1e-08 34.8 4.9 2.4e-08 33.7 4.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA75464.1 - 1.2e-08 34.7 9.7 2.4e-08 33.7 9.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) F-box-like PF12937.7 EFA75464.1 - 6.4e-08 32.4 0.3 1.8e-07 30.9 0.3 1.8 1 0 0 1 1 1 1 F-box-like zf-C3HC4 PF00097.25 EFA75464.1 - 6.4e-07 29.1 8.9 6.4e-07 29.1 8.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA75464.1 - 8.1e-07 28.9 8.5 8.1e-07 28.9 8.5 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFA75464.1 - 1.1e-06 28.6 11.2 3.7e-06 27.0 11.2 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFA75464.1 - 2.4e-06 27.7 9.3 6.6e-06 26.4 9.3 1.8 1 0 0 1 1 1 1 Ring finger domain F-box PF00646.33 EFA75464.1 - 3.4e-06 26.8 0.6 6.9e-06 25.8 0.6 1.5 1 0 0 1 1 1 1 F-box domain Prok-RING_4 PF14447.6 EFA75464.1 - 7.6e-05 22.5 7.2 7.6e-05 22.5 7.2 2.1 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EFA75464.1 - 0.00067 19.4 3.3 0.003 17.3 3.3 2.1 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EFA75464.1 - 0.00091 19.3 5.1 0.0031 17.6 5.1 1.9 1 0 0 1 1 1 1 zinc RING finger of MSL2 Nup160 PF11715.8 EFA75464.1 - 0.0014 17.4 4.0 0.21 10.2 1.3 3.3 2 1 1 3 3 3 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFA75464.1 - 0.0048 17.2 1.7 1.9 8.8 0.1 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain zf-ANAPC11 PF12861.7 EFA75464.1 - 0.0065 16.5 0.4 0.017 15.2 0.4 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFA75464.1 - 0.016 15.5 7.2 0.044 14.1 7.2 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Orf78 PF06024.12 EFA75464.1 - 0.034 14.4 4.1 0.067 13.5 4.1 1.4 1 0 0 1 1 1 0 Orf78 (ac78) dsRBD2 PF17842.1 EFA75464.1 - 0.077 13.2 0.6 0.21 11.8 0.6 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 U-box PF04564.15 EFA75464.1 - 0.14 12.4 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 U-box domain zf-RING_6 PF14835.6 EFA75464.1 - 0.39 10.6 3.7 0.95 9.4 3.7 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Apc15p PF05841.11 EFA75464.1 - 2.5 8.9 12.3 5.5 7.8 12.3 1.5 1 0 0 1 1 1 0 Apc15p protein ATP-synt PF00231.19 EFA75465.1 - 3e-62 210.9 0.6 3.4e-62 210.7 0.6 1.0 1 0 0 1 1 1 1 ATP synthase DUF4106 PF13388.6 EFA75465.1 - 0.021 14.0 0.2 0.032 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) SAPS PF04499.15 EFA75466.1 - 2e-52 178.6 2.3 1.7e-42 145.9 1.2 3.3 2 1 1 3 3 3 2 SIT4 phosphatase-associated protein Proteasome PF00227.26 EFA75466.1 - 6.9e-49 165.9 0.2 1e-48 165.4 0.2 1.3 1 0 0 1 1 1 1 Proteasome subunit UPF0172 PF03665.13 EFA75467.1 - 3.9e-47 160.8 0.0 4.6e-47 160.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 EFA75467.1 - 0.0002 21.3 0.0 0.00031 20.7 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RAB3GAP2_N PF14655.6 EFA75467.1 - 0.043 13.1 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Laminin_EGF PF00053.24 EFA75468.1 - 0.012 15.8 29.6 0.057 13.6 10.7 3.1 2 1 1 3 3 3 0 Laminin EGF domain DiS_P_DiS PF06750.13 EFA75468.1 - 4.3 7.5 7.0 25 5.1 0.4 3.3 4 0 0 4 4 4 0 Bacterial Peptidase A24 N-terminal domain Sgf11 PF08209.11 EFA75469.1 - 9.1e-13 47.5 0.3 2.1e-12 46.4 0.3 1.6 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) SEC-C PF02810.15 EFA75470.1 - 2.8e-05 23.9 6.9 5.8e-05 22.9 6.9 1.6 1 0 0 1 1 1 1 SEC-C motif RD3 PF14473.6 EFA75470.1 - 0.0031 17.3 0.2 0.0057 16.5 0.2 1.4 1 0 0 1 1 1 1 RD3 protein PIN_12 PF16289.5 EFA75470.1 - 0.0081 16.7 0.4 0.0081 16.7 0.4 2.1 2 0 0 2 2 2 1 PIN domain DUF1320 PF07030.12 EFA75470.1 - 0.055 13.6 0.1 0.25 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1320) FTCD_C PF04961.12 EFA75470.1 - 0.23 11.2 1.0 2.4 7.9 0.0 2.3 2 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase SR-25 PF10500.9 EFA75470.1 - 9.3 5.8 16.8 12 5.4 1.9 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein SPA PF08616.10 EFA75471.1 - 1.2e-12 47.8 0.4 2.1e-12 47.0 0.4 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EFA75471.1 - 2.3e-09 36.4 1.4 6.5e-05 21.8 0.5 2.2 1 1 1 2 2 2 2 Transport protein Avl9 DUF2347 PF09804.9 EFA75471.1 - 3.1e-06 27.0 0.2 6.4e-06 26.0 0.2 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 EFA75471.1 - 0.024 14.6 0.2 0.053 13.5 0.2 1.5 1 0 0 1 1 1 0 DENN (AEX-3) domain HtrL_YibB PF09612.10 EFA75471.1 - 0.051 13.1 2.7 0.38 10.2 0.5 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (HtrL_YibB) HMA PF00403.26 EFA75471.1 - 0.11 12.9 0.3 1 9.8 0.0 2.4 2 0 0 2 2 2 0 Heavy-metal-associated domain Pkinase PF00069.25 EFA75473.1 - 2.3e-12 46.8 0.0 6.9e-12 45.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75473.1 - 1.3e-09 37.7 0.0 1.9e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA75473.1 - 6.8e-05 22.3 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PAP2 PF01569.21 EFA75474.1 - 9.3e-10 38.4 3.9 9.3e-10 38.4 3.9 2.2 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EFA75474.1 - 0.00014 21.6 3.5 0.00014 21.6 3.5 2.2 2 0 0 2 2 2 1 PAP2 superfamily Androgen_recep PF02166.16 EFA75474.1 - 0.066 12.1 5.7 0.12 11.2 5.7 1.3 1 0 0 1 1 1 0 Androgen receptor Menin PF05053.13 EFA75474.1 - 1.1 7.6 16.0 1.9 6.7 16.0 1.4 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 EFA75474.1 - 3.2 6.4 11.4 10 4.7 11.4 1.9 1 0 0 1 1 1 0 Presenilin Sde2_N_Ubi PF13019.6 EFA75475.1 - 0.27 11.0 2.1 0.3 10.9 1.6 1.4 1 1 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Coiled PF05710.12 EFA75475.1 - 7.1 7.5 13.2 46 4.9 14.3 1.7 1 1 1 2 2 2 0 Coiled coil Coiled PF05710.12 EFA75476.1 - 3.8 8.4 13.3 4.2 8.3 13.3 1.2 1 1 0 1 1 1 0 Coiled coil Rsc14 PF08586.10 EFA75478.1 - 0.007 17.2 0.9 0.007 17.2 0.9 2.4 2 1 0 2 2 2 1 RSC complex, Rsc14/Ldb7 subunit Kelch_6 PF13964.6 EFA75478.1 - 0.16 12.3 2.3 3.1 8.2 0.2 3.2 3 1 0 3 3 3 0 Kelch motif RPW8 PF05659.11 EFA75478.1 - 0.77 9.4 6.1 3.4 7.4 2.8 2.9 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Mit_KHE1 PF10173.9 EFA75478.1 - 4.5 7.3 10.5 9.4 6.3 10.1 2.0 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Peptidase_M16 PF00675.20 EFA75480.1 - 1.6e-35 122.3 0.4 6.7e-35 120.3 0.1 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EFA75480.1 - 5.7e-25 88.2 0.2 9.4e-25 87.5 0.2 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EFA75480.1 - 5.5e-20 72.1 3.6 1.5e-17 64.2 0.1 3.3 4 0 0 4 4 4 2 Peptidase M16 inactive domain Aldedh PF00171.22 EFA75481.1 - 7.4e-80 268.7 0.0 9.1e-80 268.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Prominin PF05478.11 EFA75481.1 - 0.015 13.3 0.6 0.023 12.7 0.6 1.2 1 0 0 1 1 1 0 Prominin RhoGAP PF00620.27 EFA75482.1 - 5.2e-29 101.0 0.1 1.8e-28 99.2 0.1 2.0 1 0 0 1 1 1 1 RhoGAP domain RPEL PF02755.15 EFA75482.1 - 0.01 15.5 0.2 0.026 14.2 0.2 1.8 1 0 0 1 1 1 1 RPEL repeat GST_C_3 PF14497.6 EFA75483.1 - 1.6e-18 66.7 0.4 2.6e-18 66.0 0.4 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA75483.1 - 7.6e-10 39.0 0.0 1.6e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA75483.1 - 4e-06 27.2 0.0 2.2e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA75483.1 - 2.5e-05 24.4 0.1 4.9e-05 23.5 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA75483.1 - 0.0021 18.1 0.0 0.0089 16.0 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Apo-CII PF05355.11 EFA75483.1 - 0.06 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein C-II ENTH PF01417.20 EFA75483.1 - 0.066 13.3 0.4 0.35 10.9 0.2 2.0 2 0 0 2 2 2 0 ENTH domain RNase_T PF00929.24 EFA75484.1 - 4.7e-35 121.6 0.4 2.1e-34 119.4 0.2 2.1 2 0 0 2 2 2 1 Exonuclease FlxA PF14282.6 EFA75484.1 - 0.00066 19.6 0.1 0.00066 19.6 0.1 2.4 2 1 0 2 2 2 1 FlxA-like protein PRANC PF09372.10 EFA75484.1 - 0.1 12.9 6.0 0.59 10.5 4.1 2.9 2 0 0 2 2 2 0 PRANC domain SlyX PF04102.12 EFA75484.1 - 0.16 12.6 0.2 0.96 10.1 0.0 2.4 2 0 0 2 2 2 0 SlyX GDPD PF03009.17 EFA75485.1 - 6.8e-35 121.0 0.0 1.3e-33 116.8 0.0 2.1 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF809 PF05663.11 EFA75485.1 - 0.00041 20.5 0.1 0.00074 19.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF809) Pkinase PF00069.25 EFA75486.1 - 1.3e-80 270.6 1.9 1.1e-42 146.3 0.0 3.9 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75486.1 - 3.5e-42 144.5 0.9 5.5e-13 48.8 0.0 4.5 3 1 1 4 4 4 4 Protein tyrosine kinase RWD PF05773.22 EFA75486.1 - 4.4e-17 62.4 0.4 2.4e-16 60.1 0.4 2.4 1 0 0 1 1 1 1 RWD domain HGTP_anticodon2 PF12745.7 EFA75486.1 - 7.8e-14 51.8 0.2 7.8e-14 51.8 0.2 4.3 4 0 0 4 4 4 1 Anticodon binding domain of tRNAs HGTP_anticodon PF03129.20 EFA75486.1 - 3e-06 27.3 0.0 7.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain PG_binding_1 PF01471.18 EFA75486.1 - 3.2e-05 24.1 0.0 7.8e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain FTA2 PF13095.6 EFA75486.1 - 0.00026 20.7 1.4 0.46 10.1 0.0 3.5 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFA75486.1 - 0.00065 19.1 0.3 0.68 9.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA75486.1 - 0.0008 19.4 0.1 0.0086 16.0 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family YkuD PF03734.14 EFA75486.1 - 0.0071 16.8 1.3 0.021 15.2 0.0 2.5 2 0 0 2 2 2 1 L,D-transpeptidase catalytic domain T3RM_EcoP15I_C PF18273.1 EFA75486.1 - 0.025 14.9 0.3 0.31 11.4 0.2 3.0 2 0 0 2 2 2 0 Type III R-M EcoP15I C-terminal domain Kinase-like PF14531.6 EFA75486.1 - 0.1 11.9 0.3 0.86 8.9 0.0 2.5 3 0 0 3 3 3 0 Kinase-like Ribosomal_L24e PF01246.20 EFA75487.1 - 8.9e-33 112.3 4.8 2.3e-32 111.0 4.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e DUF3430 PF11912.8 EFA75488.1 - 7.4e-21 75.2 18.9 8.2e-21 75.0 18.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) FERM_F1 PF18379.1 EFA75488.1 - 0.051 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 FERM F1 ubiquitin-like domain Glyco_hydro_30C PF17189.4 EFA75488.1 - 0.094 13.0 0.1 0.23 11.7 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain Arm PF00514.23 EFA75489.1 - 2.6e-12 46.3 10.2 2.9e-07 30.3 0.2 5.8 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Symplekin_C PF12295.8 EFA75489.1 - 0.0015 18.7 0.9 0.0035 17.4 0.1 2.2 3 1 0 3 3 3 1 Symplekin tight junction protein C terminal HEAT_EZ PF13513.6 EFA75489.1 - 0.0043 17.5 0.1 7 7.3 0.0 4.5 5 1 1 6 6 6 1 HEAT-like repeat HEAT PF02985.22 EFA75489.1 - 0.28 11.6 3.1 4.1 7.9 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat WW PF00397.26 EFA75490.1 - 6.7e-13 48.5 11.7 1.8e-07 31.1 4.3 2.6 2 0 0 2 2 2 2 WW domain RPEL PF02755.15 EFA75490.1 - 0.00033 20.2 0.1 0.00092 18.8 0.1 1.7 1 0 0 1 1 1 1 RPEL repeat IQ PF00612.27 EFA75490.1 - 0.088 12.7 5.0 0.29 11.1 5.0 1.9 1 1 0 1 1 1 0 IQ calmodulin-binding motif DUF5496 PF17600.2 EFA75490.1 - 0.4 10.7 2.2 11 6.1 0.2 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5496) Band_3_cyto PF07565.13 EFA75490.1 - 4.1 7.1 10.6 7.8 6.2 10.6 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Fer4_18 PF13746.6 EFA75491.1 - 7 6.9 7.4 1 9.6 0.5 3.1 1 1 0 2 2 2 0 4Fe-4S dicluster domain NST1 PF13945.6 EFA75493.1 - 0.021 15.0 9.8 0.04 14.0 9.8 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator zf-NF-X1 PF01422.17 EFA75493.1 - 0.026 14.6 35.0 0.31 11.1 13.7 3.0 2 1 0 2 2 2 0 NF-X1 type zinc finger NCBP3 PF10309.9 EFA75493.1 - 0.069 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 Menin PF05053.13 EFA75493.1 - 1.8 6.9 9.2 2.3 6.5 9.2 1.2 1 0 0 1 1 1 0 Menin DUF4834 PF16118.5 EFA75493.1 - 3.8 8.5 13.6 15 6.6 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 EFA75494.1 - 3.4e-38 130.1 22.6 2.5e-11 44.0 0.1 8.0 3 3 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75494.1 - 8e-34 115.6 17.7 1e-06 29.1 0.0 10.3 6 1 4 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75494.1 - 2.6e-32 110.5 20.4 0.00099 19.4 0.0 13.4 4 2 8 13 13 13 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75494.1 - 5.9e-22 75.4 15.4 0.12 13.0 0.0 13.8 12 1 2 14 14 14 5 Ankyrin repeat DUF5049 PF16468.5 EFA75494.1 - 4.4e-06 26.5 1.2 1.8 8.5 0.0 7.2 7 1 1 8 8 8 1 Domain of unknown function (DUF5049) AAA_lid_9 PF17871.1 EFA75494.1 - 0.83 9.6 0.0 0.83 9.6 0.0 2.4 2 1 0 2 2 2 0 AAA lid domain Ank PF00023.30 EFA75494.1 - 1 9.9 19.8 53 4.5 0.0 9.0 8 3 3 11 11 11 0 Ankyrin repeat YmaF PF12788.7 EFA75494.1 - 2 9.0 8.2 35 5.0 0.3 4.3 4 1 0 4 4 4 0 YmaF family PH PF00169.29 EFA75495.1 - 1e-09 38.8 0.3 3.9e-09 37.0 0.1 2.3 2 0 0 2 2 2 1 PH domain SAM_1 PF00536.30 EFA75495.1 - 7.2e-09 36.0 0.0 1.5e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA75495.1 - 1e-05 25.6 0.0 2.3e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4139 PF13598.6 EFA75495.1 - 1.4e-05 25.0 0.0 4.4e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4139) PH_11 PF15413.6 EFA75495.1 - 0.0003 21.1 0.1 0.00087 19.7 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFA75495.1 - 0.036 14.4 0.1 0.1 12.9 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain polyprenyl_synt PF00348.17 EFA75498.1 - 4e-64 216.1 0.0 4.6e-64 215.9 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase DUF5048 PF16467.5 EFA75498.1 - 0.029 14.6 0.1 0.64 10.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5048) FAA_hydrolase PF01557.18 EFA75499.1 - 2.8e-36 125.3 0.0 3.3e-29 102.1 0.0 2.1 1 1 1 2 2 2 2 Fumarylacetoacetate (FAA) hydrolase family ISP1_C PF18161.1 EFA75499.1 - 0.042 13.9 0.0 1.1 9.3 0.0 2.5 2 1 0 2 2 2 0 ISP1 C-terminal COMM_domain PF07258.14 EFA75501.1 - 8.2e-15 54.7 0.3 1.1e-14 54.2 0.3 1.2 1 0 0 1 1 1 1 COMM domain DUF1986 PF09342.11 EFA75501.1 - 0.14 12.5 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Amidohydro_2 PF04909.14 EFA75502.1 - 5.9e-22 78.8 0.0 6.9e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Gemini_AC4_5_2 PF08464.10 EFA75502.1 - 0.12 12.3 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region UCH PF00443.29 EFA75503.1 - 1.9e-21 76.7 0.0 1.9e-21 76.7 0.0 2.7 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA75503.1 - 6.6e-10 39.1 10.2 6.6e-10 39.1 10.2 3.5 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF484 PF04340.12 EFA75503.1 - 0.019 14.7 0.6 2.4 7.8 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF484 Sedlin_N PF04628.13 EFA75504.1 - 0.093 12.8 0.1 0.093 12.8 0.1 1.1 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region 2-Hacid_dh_C PF02826.19 EFA75505.1 - 2e-49 167.4 0.0 3.8e-49 166.4 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFA75505.1 - 4.5e-30 104.0 0.0 6.3e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFA75505.1 - 0.0011 19.2 0.1 0.0026 17.9 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 EFA75505.1 - 0.0022 18.5 0.1 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 XdhC Rossmann domain ACT PF01842.25 EFA75505.1 - 0.032 14.0 0.3 6.6 6.6 0.0 2.8 3 0 0 3 3 3 0 ACT domain IlvN PF07991.12 EFA75505.1 - 0.14 11.7 0.1 1.6 8.3 0.0 2.4 2 1 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Guanylate_cyc PF00211.20 EFA75506.1 - 7.1e-43 146.4 1.3 2.1e-40 138.3 0.1 3.0 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain Nop14 PF04147.12 EFA75506.1 - 5.6 5.1 12.5 11 4.1 12.5 1.3 1 0 0 1 1 1 0 Nop14-like family p450 PF00067.22 EFA75507.1 - 9e-95 318.1 0.3 1e-94 317.9 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 DASH_Dad3 PF08656.10 EFA75507.1 - 0.0056 16.7 0.1 0.029 14.5 0.0 2.1 2 0 0 2 2 2 1 DASH complex subunit Dad3 Baculo_p48 PF04878.13 EFA75507.1 - 0.0058 15.6 2.6 0.0093 14.9 2.6 1.2 1 0 0 1 1 1 1 Baculovirus P48 protein Actin PF00022.19 EFA75508.1 - 1.1e-14 53.9 0.0 1.4e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Actin SRF-TF PF00319.18 EFA75508.1 - 0.28 10.7 1.6 0.29 10.7 0.3 1.7 2 0 0 2 2 2 0 SRF-type transcription factor (DNA-binding and dimerisation domain) Actin PF00022.19 EFA75509.1 - 2e-05 23.4 0.3 0.00051 18.8 0.1 2.0 1 1 1 2 2 2 2 Actin p450 PF00067.22 EFA75510.1 - 2.4e-94 316.7 0.2 2.7e-94 316.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Baculo_p48 PF04878.13 EFA75510.1 - 0.00039 19.5 1.7 0.00064 18.8 1.7 1.2 1 0 0 1 1 1 1 Baculovirus P48 protein DASH_Dad3 PF08656.10 EFA75510.1 - 0.0057 16.7 0.1 0.029 14.5 0.0 2.1 2 0 0 2 2 2 1 DASH complex subunit Dad3 PDH PF02153.17 EFA75510.1 - 0.096 11.7 0.0 0.27 10.2 0.0 1.7 2 0 0 2 2 2 0 Prephenate dehydrogenase RhoGAP PF00620.27 EFA75512.1 - 3.7e-26 91.8 0.1 1.1e-25 90.2 0.1 1.9 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EFA75512.1 - 5.2e-11 42.7 2.1 6.1e-11 42.5 0.3 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF2229 PF09989.9 EFA75512.1 - 0.037 13.7 2.5 0.059 13.0 1.7 1.7 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF5363 PF17320.2 EFA75512.1 - 0.31 11.0 1.5 3 7.8 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5363) Cellulose_synt PF03552.14 EFA75513.1 - 1.3e-23 83.5 8.1 4.4e-14 52.0 1.6 3.6 3 1 1 4 4 4 3 Cellulose synthase Glyco_trans_2_3 PF13632.6 EFA75513.1 - 1.9e-21 76.9 0.1 1.9e-21 76.9 0.1 2.4 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFA75513.1 - 1.5e-16 61.0 0.0 5.4e-16 59.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFA75513.1 - 2e-12 47.3 0.0 9.2e-11 41.8 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EFA75513.1 - 1.4e-08 34.4 0.0 2.4e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 DUF1573 PF07610.11 EFA75514.1 - 0.0012 18.8 0.9 0.049 13.7 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 EFA75515.1 - 2.5e-06 27.6 0.6 0.00011 22.3 0.0 3.3 3 0 0 3 3 3 1 Transmembrane protein 131-like Mucin PF01456.17 EFA75515.1 - 0.27 11.2 11.3 0.8 9.7 11.3 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein TFIIA PF03153.13 EFA75515.1 - 1.1 9.2 78.5 0.043 13.8 9.3 3.1 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Thioredoxin PF00085.20 EFA75516.1 - 5.7e-08 32.7 0.1 8.8e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EFA75516.1 - 4.6e-06 25.8 0.6 5.1e-06 25.6 0.6 1.1 1 0 0 1 1 1 1 Phosducin Peptidase_M4 PF01447.18 EFA75516.1 - 0.0059 17.1 0.4 0.0081 16.7 0.4 1.2 1 0 0 1 1 1 1 Thermolysin metallopeptidase, catalytic domain DUF5095 PF17016.5 EFA75516.1 - 0.028 14.1 1.8 0.041 13.6 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5095) TraN PF06986.11 EFA75516.1 - 0.073 12.8 0.4 0.087 12.5 0.4 1.1 1 0 0 1 1 1 0 Type-1V conjugative transfer system mating pair stabilisation Thioredoxin_2 PF13098.6 EFA75516.1 - 0.13 12.8 0.1 0.32 11.5 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin-like domain 60KD_IMP PF02096.20 EFA75517.1 - 2.8e-19 69.6 6.1 4.9e-19 68.8 6.1 1.4 1 0 0 1 1 1 1 60Kd inner membrane protein DUF3439 PF11921.8 EFA75518.1 - 0.0079 16.2 0.8 0.034 14.1 0.8 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) DUF924 PF06041.11 EFA75519.1 - 9.1e-54 182.3 0.0 1.1e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) TipAS PF07739.13 EFA75519.1 - 0.09 13.3 0.0 2.8 8.5 0.0 2.3 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Palm_thioest PF02089.15 EFA75520.1 - 1e-73 248.2 0.0 1.2e-73 247.9 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EFA75520.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) TMEM164 PF14808.6 EFA75521.1 - 9.5e-09 35.0 0.8 1.3e-08 34.5 0.8 1.2 1 0 0 1 1 1 1 TMEM164 family Intg_mem_TP0381 PF09529.10 EFA75521.1 - 0.048 13.2 4.6 0.065 12.7 4.6 1.4 1 1 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) MFS_5 PF05631.14 EFA75523.1 - 5.8e-100 334.6 17.1 8.6e-100 334.1 17.1 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EFA75523.1 - 9.3e-21 74.1 34.3 9.3e-21 74.1 34.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4044 PF13253.6 EFA75523.1 - 3.1 7.4 6.4 0.82 9.2 1.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) SF3A2 PF16835.5 EFA75524.1 - 2e-36 124.2 0.0 3.5e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EFA75524.1 - 1.4e-06 28.5 1.5 2.6e-06 27.6 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EFA75524.1 - 0.00029 20.8 0.2 0.0006 19.7 0.2 1.7 1 1 0 1 1 1 1 Cactus-binding C-terminus of cactin protein RUN PF02759.19 EFA75526.1 - 1e-22 80.5 0.4 1e-22 80.5 0.4 2.4 2 0 0 2 2 2 1 RUN domain SUIM_assoc PF16619.5 EFA75526.1 - 0.079 13.0 28.5 0.013 15.5 11.4 4.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 HD PF01966.22 EFA75527.1 - 0.0005 20.3 0.6 0.0012 19.1 0.6 1.7 1 1 0 1 1 1 1 HD domain SbsC_C PF18058.1 EFA75527.1 - 0.057 13.6 0.4 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 SbsC C-terminal domain Ras PF00071.22 EFA75528.1 - 4.8e-47 159.6 0.0 5.7e-47 159.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75528.1 - 5e-22 78.4 0.0 8e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75528.1 - 1.1e-05 25.0 0.0 1.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA75528.1 - 0.027 14.4 0.0 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase DUF987 PF06174.11 EFA75528.1 - 0.053 13.4 0.0 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF987) Peptidase_S9 PF00326.21 EFA75529.1 - 8.4e-48 162.7 0.0 3.3e-47 160.7 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 EFA75529.1 - 1.8e-29 102.8 14.3 5.8e-29 101.1 14.3 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Esterase PF00756.20 EFA75529.1 - 0.026 14.2 0.2 0.098 12.3 0.0 2.0 2 0 0 2 2 2 0 Putative esterase Esterase_phd PF10503.9 EFA75529.1 - 0.25 10.8 0.1 0.37 10.2 0.1 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase zf-3CxxC_2 PF17180.4 EFA75531.1 - 0.011 16.4 1.1 0.029 15.1 1.1 1.7 1 0 0 1 1 1 0 Zinc-binding domain CIA30 PF08547.12 EFA75532.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Complex I intermediate-associated protein 30 (CIA30) Wzt_C PF14524.6 EFA75535.1 - 0.015 15.4 0.1 0.14 12.2 0.0 2.7 2 0 0 2 2 2 0 Wzt C-terminal domain Ank_2 PF12796.7 EFA75536.1 - 7.4e-15 55.3 2.9 0.0014 19.2 0.0 4.6 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75536.1 - 5.7e-13 49.1 6.1 0.14 12.8 0.1 7.8 3 1 5 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75536.1 - 1.4e-07 31.2 3.7 11 7.0 0.0 8.9 8 2 3 11 11 11 1 Ankyrin repeat Ank_5 PF13857.6 EFA75536.1 - 7.6e-07 29.3 1.3 0.024 15.0 0.0 5.7 4 1 1 5 5 5 1 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA75536.1 - 1.9e-05 24.5 8.1 0.1 12.5 0.1 4.8 2 2 2 4 4 4 3 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA75537.1 - 1.6e-06 28.6 0.2 0.15 12.7 0.0 4.0 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75537.1 - 1e-05 25.9 2.0 1.4 9.5 0.0 5.7 3 2 4 7 7 7 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75537.1 - 5.3e-05 23.3 0.5 36 5.4 0.0 6.1 7 0 0 7 7 7 1 Ankyrin repeat Ank_5 PF13857.6 EFA75537.1 - 0.00022 21.5 0.5 14 6.2 0.0 4.8 5 1 2 7 7 7 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75538.1 - 2.6e-09 37.5 2.4 0.011 16.3 0.1 4.5 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75538.1 - 6.1e-07 29.9 1.7 3.4 8.3 0.0 6.4 5 2 0 5 5 5 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75538.1 - 0.00039 20.7 0.3 9.7 6.6 0.0 5.3 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75538.1 - 0.00093 19.5 1.9 19 6.3 0.0 5.6 7 0 0 7 7 7 1 Ankyrin repeat DUF3447 PF11929.8 EFA75538.1 - 0.049 13.6 22.0 1.1 9.3 0.5 6.5 2 2 4 6 6 6 0 Domain of unknown function (DUF3447) ArnB_C PF18677.1 EFA75538.1 - 0.23 11.6 1.8 1.6 8.9 0.4 2.4 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain Ank_2 PF12796.7 EFA75539.1 - 4.5e-10 40.0 0.3 0.024 15.2 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75539.1 - 9e-08 32.5 0.9 1.2 9.8 0.0 6.3 5 2 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75539.1 - 5.8e-06 26.2 2.3 12 6.9 0.0 6.7 9 0 0 9 9 9 2 Ankyrin repeat Ank_5 PF13857.6 EFA75539.1 - 4.7e-05 23.6 0.1 15 6.1 0.0 5.7 4 1 1 6 6 6 1 Ankyrin repeats (many copies) Ribosomal_L18_c PF14204.6 EFA75540.1 - 4.6e-26 91.6 7.0 6.5e-26 91.1 7.0 1.3 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Ribosomal_L5e PF17144.4 EFA75540.1 - 3.7e-13 49.8 1.5 4.7e-13 49.4 0.0 1.9 2 1 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Thr_synth_N PF14821.6 EFA75540.1 - 0.0099 16.1 0.1 1.3 9.3 0.0 2.8 2 1 0 2 2 2 1 Threonine synthase N terminus ABC_membrane_3 PF13748.6 EFA75540.1 - 0.11 11.7 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region Pkinase_Tyr PF07714.17 EFA75541.1 - 2e-64 217.4 0.0 3.6e-64 216.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75541.1 - 2.2e-48 164.9 0.0 7e-48 163.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Helicase_C PF00271.31 EFA75541.1 - 3.4e-15 56.4 1.5 1.1e-12 48.2 0.0 3.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA75541.1 - 1.4e-14 54.5 0.1 3.5e-14 53.2 0.1 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA75541.1 - 7.4e-13 48.6 0.0 1.5e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 EFA75541.1 - 5.6e-12 46.2 0.4 0.0002 22.0 0.1 3.0 3 0 0 3 3 2 2 Double-stranded RNA binding motif Pkinase_fungal PF17667.1 EFA75541.1 - 0.0015 17.4 0.0 0.0028 16.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF1539 PF07560.11 EFA75541.1 - 0.045 13.8 0.9 0.14 12.2 0.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) DUF4333 PF14230.6 EFA75541.1 - 0.12 12.6 0.1 0.45 10.8 0.0 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4333) Flavi_DEAD PF07652.14 EFA75541.1 - 0.17 11.9 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain APH PF01636.23 EFA75541.1 - 0.17 11.8 0.0 5.3 6.9 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Aminotran_1_2 PF00155.21 EFA75542.1 - 7.8e-53 179.9 0.0 9.6e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II IL7 PF01415.16 EFA75542.1 - 0.1 12.6 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Interleukin 7/9 family Usp PF00582.26 EFA75543.1 - 3.7e-18 66.4 0.0 5.8e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family DUF892 PF05974.12 EFA75543.1 - 0.014 15.4 0.7 0.028 14.5 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF892) DDE_Tnp_IS240 PF13610.6 EFA75543.1 - 0.13 12.5 0.3 9.8 6.4 0.0 2.9 2 1 1 3 3 3 0 DDE domain Myosin_head PF00063.21 EFA75546.1 - 1.3e-258 859.8 8.7 2.2e-258 859.0 8.7 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 EFA75546.1 - 1.6e-48 163.7 0.6 2.4e-24 85.9 0.1 3.2 2 0 0 2 2 2 2 MyTH4 domain SH3_2 PF07653.17 EFA75546.1 - 1.2e-10 40.9 0.0 2.9e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain IQ PF00612.27 EFA75546.1 - 1.8e-10 39.7 14.5 0.00039 20.0 2.7 4.7 4 0 0 4 4 4 3 IQ calmodulin-binding motif SH3_9 PF14604.6 EFA75546.1 - 3.4e-08 33.2 0.0 6.4e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA75546.1 - 9.3e-08 31.6 0.0 2.3e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain FERM_M PF00373.18 EFA75546.1 - 5.2e-07 30.1 9.4 0.0002 21.8 0.4 3.9 3 0 0 3 3 2 2 FERM central domain RA PF00788.23 EFA75546.1 - 3.8e-06 27.5 0.0 0.0021 18.7 0.0 3.4 3 0 0 3 3 2 1 Ras association (RalGDS/AF-6) domain AAA_22 PF13401.6 EFA75546.1 - 0.039 14.2 0.0 0.29 11.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA75546.1 - 0.057 13.8 0.0 0.057 13.8 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Atg14 PF10186.9 EFA75546.1 - 2.1 7.3 17.3 5.3 6.0 17.3 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nop53 PF07767.11 EFA75546.1 - 5.6 6.3 37.8 10 5.4 37.8 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) FERM_C PF09380.10 EFA75546.1 - 7.4 7.0 7.0 0.92 9.9 0.1 3.2 3 0 0 3 3 2 0 FERM C-terminal PH-like domain Ank_5 PF13857.6 EFA75547.1 - 4.7e-13 49.1 4.5 0.0025 18.1 0.1 6.3 2 1 5 7 7 7 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75547.1 - 9.2e-13 48.4 5.0 0.00027 21.5 0.1 6.1 5 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75547.1 - 2.2e-11 44.2 1.1 0.00083 19.9 0.2 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75547.1 - 4.7e-08 32.7 5.6 11 7.0 0.0 8.0 7 1 1 8 8 8 2 Ankyrin repeat AbiEi_3_N PF17194.4 EFA75547.1 - 0.015 15.3 0.1 0.38 10.8 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain DUF521 PF04412.13 EFA75549.1 - 0.093 11.4 0.0 0.098 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Glycogen_syn PF05693.13 EFA75550.1 - 2.4e-113 379.9 0.0 4.4e-113 379.0 0.0 1.4 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EFA75550.1 - 0.00018 21.1 0.0 0.00041 19.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA75550.1 - 0.032 14.6 0.0 0.06 13.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 PWWP PF00855.17 EFA75550.1 - 1.8 9.0 4.8 4.3 7.8 4.8 1.6 1 0 0 1 1 1 0 PWWP domain Pkinase PF00069.25 EFA75551.1 - 3.3e-77 259.4 0.0 5e-77 258.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75551.1 - 3.4e-44 151.1 0.0 5.2e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EFA75551.1 - 1.7e-15 56.5 0.0 3.2e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EFA75551.1 - 8e-07 28.7 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFA75551.1 - 1.6e-05 24.0 0.3 1.6e-05 24.0 0.3 2.8 3 0 0 3 3 1 1 Haspin like kinase domain RIO1 PF01163.22 EFA75551.1 - 5.5e-05 22.8 0.4 5.5e-05 22.8 0.4 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EFA75551.1 - 0.0003 20.8 0.0 0.003 17.5 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA75551.1 - 0.0017 17.7 0.1 0.0035 16.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.9 EFA75551.1 - 0.022 13.6 0.1 0.036 12.9 0.1 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC UBA_2 PF08587.11 EFA75551.1 - 0.027 14.6 0.2 0.081 13.0 0.2 1.8 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) UBA PF00627.31 EFA75551.1 - 0.077 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 UBA/TS-N domain Pex2_Pex12 PF04757.14 EFA75552.1 - 7.8e-21 74.7 11.1 7.8e-21 74.7 11.1 3.1 2 1 0 2 2 2 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 EFA75552.1 - 3.2e-09 36.5 8.1 4.8e-09 35.9 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA75552.1 - 1.5e-07 31.6 12.5 2.4e-07 31.0 12.5 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFA75552.1 - 5.9e-07 29.2 9.3 1e-06 28.5 9.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFA75552.1 - 6.1e-07 29.2 11.9 9.5e-07 28.6 11.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA75552.1 - 3e-06 27.0 12.5 5.7e-06 26.1 12.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA75552.1 - 1.5e-05 25.2 6.7 3e-05 24.2 6.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFA75552.1 - 0.00048 20.1 4.9 0.00048 20.1 4.9 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA75552.1 - 0.0034 17.3 10.1 0.0063 16.4 10.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFA75552.1 - 0.0097 16.0 12.5 0.017 15.3 12.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SOG2 PF10428.9 EFA75552.1 - 0.042 13.1 6.1 0.052 12.8 6.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein zf-ANAPC11 PF12861.7 EFA75552.1 - 0.057 13.5 2.6 0.1 12.7 2.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EFA75552.1 - 0.17 11.8 5.5 0.33 10.9 5.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFA75552.1 - 0.34 10.7 9.5 0.64 9.8 9.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Menin PF05053.13 EFA75552.1 - 1.9 6.8 5.5 2.7 6.3 5.5 1.2 1 0 0 1 1 1 0 Menin zinc_ribbon_15 PF17032.5 EFA75553.1 - 3.6e-06 27.6 0.2 4.1e-06 27.4 0.2 1.3 1 1 0 1 1 1 1 zinc-ribbon family F5_F8_type_C PF00754.25 EFA75554.1 - 2.3e-21 76.2 0.8 4.7e-21 75.2 0.8 1.5 1 0 0 1 1 1 1 F5/8 type C domain H_lectin PF09458.10 EFA75554.1 - 2.8e-18 65.9 0.9 5.5e-18 64.9 0.9 1.5 1 0 0 1 1 1 1 H-type lectin domain PmoA PF14100.6 EFA75554.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Methane oxygenase PmoA F5_F8_type_C PF00754.25 EFA75555.1 - 1.8e-21 76.6 1.5 2.6e-21 76.0 1.5 1.2 1 0 0 1 1 1 1 F5/8 type C domain H_lectin PF09458.10 EFA75555.1 - 2e-16 59.9 2.9 6.6e-16 58.3 2.9 1.9 1 0 0 1 1 1 1 H-type lectin domain DUF3557 PF12078.8 EFA75555.1 - 0.12 12.3 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) Ank_2 PF12796.7 EFA75556.1 - 3.9e-45 152.3 6.7 5.7e-11 42.8 0.0 5.6 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75556.1 - 2.1e-31 107.8 2.4 4.9e-06 27.0 0.1 6.8 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EFA75556.1 - 3.7e-27 93.5 6.3 3.3e-05 24.1 0.0 8.1 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFA75556.1 - 2.7e-24 84.9 10.7 6.2e-06 26.4 0.1 7.5 6 1 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75556.1 - 1.8e-17 61.6 3.5 0.076 13.6 0.0 8.7 8 1 0 8 8 8 5 Ankyrin repeat BTB PF00651.31 EFA75556.1 - 1.6e-16 60.5 1.1 1.5e-06 28.4 0.0 4.4 4 0 0 4 4 4 3 BTB/POZ domain TPR_12 PF13424.6 EFA75557.1 - 6.4e-08 32.8 0.2 1e-07 32.1 0.2 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat eIF3_subunit PF08597.10 EFA75558.1 - 1.2 9.0 24.6 1.5 8.6 24.6 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF3292 PF11696.8 EFA75558.1 - 2.2 6.6 5.1 2.6 6.3 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF4614 PF15391.6 EFA75558.1 - 8.8 6.3 12.9 9.9 6.1 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) KOW PF00467.29 EFA75559.1 - 2.2e-17 62.3 25.4 5.1e-07 29.4 0.4 7.0 7 0 0 7 7 7 3 KOW motif DUF3912 PF13051.6 EFA75559.1 - 0.0027 17.9 1.1 2.2 8.6 0.0 4.8 5 0 0 5 5 5 1 Protein of unknown function (DUF3912) SH3_2 PF07653.17 EFA75559.1 - 0.012 15.3 1.1 0.74 9.6 0.0 3.6 3 0 0 3 3 3 0 Variant SH3 domain DUF2187 PF09953.9 EFA75559.1 - 0.042 13.8 0.6 0.29 11.2 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) Ubiquitin_3 PF14836.6 EFA75559.1 - 0.15 12.0 0.0 0.46 10.5 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain AbiH PF14253.6 EFA75560.1 - 0.012 15.5 0.3 0.021 14.7 0.3 1.4 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH zf-rbx1 PF12678.7 EFA75561.1 - 2.3e-06 27.8 7.4 5.3e-05 23.4 7.4 2.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFA75561.1 - 2.4e-05 24.6 2.8 2.4e-05 24.6 2.8 2.7 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA75561.1 - 0.001 18.9 6.2 0.01 15.7 3.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA75561.1 - 0.0021 17.9 7.3 0.018 14.9 7.3 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFA75561.1 - 0.013 15.5 0.7 0.013 15.5 0.7 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 EFA75561.1 - 0.025 14.6 3.5 0.12 12.4 3.5 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_5 PF14634.6 EFA75561.1 - 0.034 14.1 4.7 0.04 13.9 1.9 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 EFA75561.1 - 0.039 13.7 7.2 0.63 9.8 3.5 2.6 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 EFA75561.1 - 0.64 10.2 7.0 0.38 10.9 2.8 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EFA75561.1 - 0.75 9.6 5.3 2 8.3 2.4 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EFA75561.1 - 2 8.8 6.7 0.36 11.2 2.3 2.1 2 0 0 2 2 2 0 RING-like domain zf-RING_UBOX PF13445.6 EFA75561.1 - 3.6 7.7 6.8 6.8 6.8 3.4 2.7 2 1 1 3 3 3 0 RING-type zinc-finger zf-C3H2C3 PF17122.5 EFA75561.1 - 4.6 7.4 10.1 30 4.8 6.1 3.3 2 1 0 2 2 2 0 Zinc-finger Ank_4 PF13637.6 EFA75562.1 - 2.5e-18 66.2 7.7 5.5e-05 23.6 0.0 7.5 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75562.1 - 6.5e-17 61.9 4.4 0.00014 22.3 0.1 4.9 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75562.1 - 3.7e-11 43.0 3.8 0.012 15.9 0.1 6.7 5 1 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75562.1 - 7.4e-07 29.0 4.3 56 4.8 0.0 8.6 10 0 0 10 10 10 0 Ankyrin repeat DUF3447 PF11929.8 EFA75562.1 - 0.09 12.7 11.4 0.3 11.1 0.1 4.9 2 2 3 5 5 5 0 Domain of unknown function (DUF3447) ENTH PF01417.20 EFA75562.1 - 0.095 12.7 0.0 1.6 8.8 0.0 2.9 3 0 0 3 3 3 0 ENTH domain Ank PF00023.30 EFA75562.1 - 0.11 13.0 0.1 18 6.0 0.0 4.3 3 1 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 EFA75563.1 - 8.3e-16 58.1 2.6 0.0042 17.6 0.1 6.1 3 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75563.1 - 3.5e-13 49.5 1.6 0.001 19.4 0.1 5.8 4 2 3 7 7 7 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75563.1 - 3e-12 46.9 1.2 0.0074 16.9 0.2 3.5 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75563.1 - 0.00033 20.9 1.1 2 9.3 0.0 6.1 8 0 0 8 8 8 1 Ankyrin repeat RloB PF13707.6 EFA75563.1 - 0.031 14.5 0.1 0.031 14.5 0.1 1.8 2 0 0 2 2 2 0 RloB-like protein Ank_4 PF13637.6 EFA75564.1 - 1.1e-13 51.4 7.5 0.0058 17.2 0.2 4.6 1 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75564.1 - 2.3e-13 50.5 1.5 1.4e-05 25.6 0.1 3.4 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75564.1 - 1.4e-10 41.2 1.7 0.05 14.0 0.0 5.7 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75564.1 - 1.4e-05 25.1 1.8 18 6.3 0.1 5.9 7 0 0 7 7 7 2 Ankyrin repeat Arf PF00025.21 EFA75565.1 - 1.5e-42 145.0 1.2 6.1e-42 143.0 1.2 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA75565.1 - 1.8e-08 34.6 0.1 2.4e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFA75565.1 - 1.8e-07 30.8 0.2 2.4e-07 30.3 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EFA75565.1 - 1.6e-06 27.8 0.2 1.9e-06 27.6 0.2 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFA75565.1 - 4.8e-06 26.0 2.0 7.7e-06 25.3 0.7 1.9 1 1 1 2 2 2 1 G-protein alpha subunit SRPRB PF09439.10 EFA75565.1 - 0.00014 21.4 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NACHT PF05729.12 EFA75565.1 - 0.041 13.8 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain IES5 PF17335.2 EFA75565.1 - 0.1 12.9 0.4 1.2 9.4 0.1 2.0 1 1 1 2 2 2 0 Ino80 complex subunit 5 Ank_2 PF12796.7 EFA75566.1 - 1.9e-19 70.0 5.5 1.7e-05 25.3 0.2 4.7 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75566.1 - 4.1e-19 68.7 5.4 4.3e-05 24.0 0.1 7.1 6 2 1 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75566.1 - 5.8e-16 58.4 5.5 0.013 15.8 0.0 8.3 3 2 7 10 10 10 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75566.1 - 5.9e-12 44.7 3.8 2.1 9.2 0.0 9.6 9 2 2 11 11 11 3 Ankyrin repeat DUF3447 PF11929.8 EFA75566.1 - 0.0044 17.0 15.0 0.073 13.0 1.5 5.2 2 1 1 4 4 4 1 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA75567.1 - 0.061 13.9 0.2 0.63 10.7 0.1 2.4 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) Ank_2 PF12796.7 EFA75568.1 - 7.4e-20 71.3 8.8 0.00035 21.1 0.3 4.5 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75568.1 - 8.8e-15 54.9 4.9 0.0055 17.3 0.0 6.6 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75568.1 - 3.7e-14 52.6 4.8 0.00053 20.2 0.0 8.5 4 1 5 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75568.1 - 8e-11 41.2 5.7 14 6.7 0.0 9.8 8 2 2 10 10 10 3 Ankyrin repeat Ank_2 PF12796.7 EFA75569.1 - 6.1e-18 65.2 6.4 0.00024 21.6 0.0 4.9 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75569.1 - 3.8e-14 52.9 10.7 0.0017 18.9 0.1 7.0 4 3 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75569.1 - 2.2e-11 42.9 5.6 0.38 11.5 0.0 9.7 11 0 0 11 11 11 2 Ankyrin repeat Ank_5 PF13857.6 EFA75569.1 - 2.2e-09 37.4 4.5 5.1 7.5 0.0 8.1 2 2 7 9 9 9 3 Ankyrin repeats (many copies) Xin PF08043.12 EFA75569.1 - 0.00063 19.3 1.1 0.21 11.3 0.0 3.1 2 0 0 2 2 2 2 Xin repeat DUF1844 PF08899.11 EFA75569.1 - 0.087 13.1 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) IF-2B PF01008.17 EFA75570.1 - 3.1e-77 259.5 0.7 5.7e-77 258.7 0.7 1.4 1 0 0 1 1 1 1 Initiation factor 2 subunit family TFIIA PF03153.13 EFA75570.1 - 0.023 14.7 45.7 0.034 14.1 45.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LSM PF01423.22 EFA75571.1 - 4.5e-13 48.7 1.1 8.2e-13 47.8 1.1 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA75571.1 - 0.00036 20.6 0.0 0.00079 19.5 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain RhoGEF PF00621.20 EFA75572.1 - 6.8e-42 143.8 8.7 1.1e-41 143.1 8.7 1.3 1 0 0 1 1 1 1 RhoGEF domain IQ_SEC7_PH PF16453.5 EFA75572.1 - 2.8e-06 27.4 0.0 7.6e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 PH domain PH PF00169.29 EFA75572.1 - 0.00017 22.0 0.3 0.00046 20.7 0.3 1.8 1 0 0 1 1 1 1 PH domain ER PF01133.17 EFA75572.1 - 0.016 15.2 0.9 0.16 12.0 1.0 2.5 1 1 0 1 1 1 0 Enhancer of rudimentary CSD2 PF17876.1 EFA75572.1 - 0.13 12.5 0.5 0.42 10.8 0.1 2.1 2 0 0 2 2 2 0 Cold shock domain TFIIA PF03153.13 EFA75572.1 - 5.3 6.9 23.7 1.8 8.5 19.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 EFA75572.1 - 8.7 5.7 9.8 1.7 8.1 0.7 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) ELMO_CED12 PF04727.13 EFA75573.1 - 2.5e-25 89.6 0.8 8.5e-25 87.9 0.0 2.4 2 0 0 2 2 2 1 ELMO/CED-12 family UBA_4 PF14555.6 EFA75573.1 - 1.3e-08 34.5 0.1 2.9e-08 33.4 0.1 1.7 1 0 0 1 1 1 1 UBA-like domain Glycoprotein_G PF00802.19 EFA75575.1 - 0.013 14.8 0.1 0.015 14.7 0.1 1.2 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G Peptidase_S7 PF00949.21 EFA75576.1 - 0.0043 16.9 0.6 0.0081 16.0 0.6 1.5 1 0 0 1 1 1 1 Peptidase S7, Flavivirus NS3 serine protease Trypsin PF00089.26 EFA75576.1 - 0.045 13.5 0.1 0.07 12.9 0.1 1.4 1 0 0 1 1 1 0 Trypsin DUF31 PF01732.16 EFA75576.1 - 0.07 12.7 0.0 0.087 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S29 PF02907.15 EFA75576.1 - 0.15 11.8 0.1 0.32 10.7 0.1 1.5 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease RRM_1 PF00076.22 EFA75578.1 - 4.5e-19 68.1 0.9 1.4e-13 50.4 0.3 3.0 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA75578.1 - 0.033 14.2 0.1 10 6.2 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Pkinase PF00069.25 EFA75580.1 - 8e-67 225.4 0.0 1.1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75580.1 - 1.7e-48 165.2 0.0 2.6e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EFA75580.1 - 5.3e-21 75.1 0.4 1.1e-20 74.1 0.4 1.6 1 0 0 1 1 1 1 PH domain PBD PF00786.28 EFA75580.1 - 1.5e-14 54.1 0.1 4.4e-14 52.6 0.1 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EFA75580.1 - 2.5e-06 26.6 0.4 1.5e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFA75580.1 - 0.00016 20.7 0.6 0.00043 19.3 0.6 1.6 1 1 0 1 1 1 1 Haspin like kinase domain PH_17 PF18012.1 EFA75580.1 - 0.00029 20.5 0.0 0.00063 19.4 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFA75580.1 - 0.0009 19.5 1.5 0.0023 18.2 0.4 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain Kinase-like PF14531.6 EFA75580.1 - 0.0048 16.2 0.1 0.02 14.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like ADP_PFK_GK PF04587.15 EFA75580.1 - 0.046 12.3 0.2 0.078 11.5 0.2 1.4 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region PH_11 PF15413.6 EFA75580.1 - 0.051 14.0 8.3 0.25 11.8 4.6 2.9 2 1 0 2 2 2 0 Pleckstrin homology domain DUF1160 PF06648.11 EFA75580.1 - 0.068 13.2 0.2 0.26 11.3 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1160) DUF1491 PF07372.12 EFA75580.1 - 0.1 13.0 0.1 0.32 11.4 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1491) PH_6 PF15406.6 EFA75580.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 EFA75580.1 - 0.14 12.5 1.9 3.2 8.1 1.9 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain PAP2 PF01569.21 EFA75582.1 - 3.4e-08 33.3 4.7 3.4e-08 33.3 4.7 2.0 2 0 0 2 2 2 1 PAP2 superfamily Actin PF00022.19 EFA75583.1 - 1.1e-75 254.8 0.0 2.2e-46 158.3 0.0 2.2 1 1 1 2 2 2 2 Actin Ank_4 PF13637.6 EFA75583.1 - 1.9e-27 95.3 4.3 0.00011 22.7 0.1 9.4 7 3 4 11 11 11 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75583.1 - 1.4e-25 89.7 6.9 5.2e-05 23.7 0.0 7.4 5 2 2 8 8 8 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75583.1 - 5.1e-16 58.5 5.8 0.12 12.8 0.0 11.4 6 4 7 13 13 13 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75583.1 - 6.7e-14 50.6 0.3 4.5 8.2 0.0 11.7 12 1 1 13 13 13 2 Ankyrin repeat DUF3447 PF11929.8 EFA75583.1 - 0.0004 20.3 6.8 0.11 12.5 0.0 5.6 4 2 1 5 5 5 1 Domain of unknown function (DUF3447) Ank PF00023.30 EFA75583.1 - 0.0092 16.4 0.2 83 3.9 0.0 5.7 5 1 0 5 5 5 0 Ankyrin repeat DUF1843 PF08898.10 EFA75583.1 - 0.15 12.6 0.0 17 6.0 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) DUF249 PF03158.13 EFA75583.1 - 0.47 10.1 5.9 7.2 6.3 0.5 4.3 2 2 2 6 6 6 0 Multigene family 530 protein Actin PF00022.19 EFA75584.1 - 5e-23 81.4 0.0 5.5e-23 81.2 0.0 1.0 1 0 0 1 1 1 1 Actin Actin PF00022.19 EFA75585.1 - 1.1e-148 495.2 0.0 3.6e-148 493.5 0.0 1.6 1 1 0 1 1 1 1 Actin MMR_HSR1 PF01926.23 EFA75586.1 - 4.6e-05 23.5 0.1 0.00042 20.4 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA75586.1 - 0.0034 17.3 1.2 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EFA75586.1 - 0.0039 16.9 0.1 0.011 15.4 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Casc1_N PF15927.5 EFA75586.1 - 0.0043 16.8 2.3 0.0043 16.8 2.3 3.5 4 0 0 4 4 4 1 Cancer susceptibility candidate 1 N-terminus Baculo_PEP_C PF04513.12 EFA75586.1 - 0.0046 17.0 6.3 0.094 12.8 0.4 3.5 3 0 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_23 PF13476.6 EFA75586.1 - 0.0066 17.0 0.7 0.0066 17.0 0.7 4.2 2 2 2 4 4 1 1 AAA domain HsbA PF12296.8 EFA75586.1 - 0.009 16.4 0.2 0.052 14.0 0.0 2.4 2 0 0 2 2 2 1 Hydrophobic surface binding protein A T2SSE PF00437.20 EFA75586.1 - 0.029 13.5 0.2 0.061 12.4 0.2 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF948 PF06103.11 EFA75586.1 - 0.03 14.6 4.5 0.061 13.6 0.4 3.1 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.11 EFA75586.1 - 0.04 14.5 10.6 1 9.9 0.4 3.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal HBM PF16591.5 EFA75586.1 - 0.055 12.9 1.4 0.12 11.8 1.4 1.5 1 0 0 1 1 1 0 Helical bimodular sensor domain AAA_22 PF13401.6 EFA75586.1 - 0.06 13.6 0.0 0.22 11.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA75586.1 - 0.06 12.7 0.7 0.13 11.6 0.1 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EFA75586.1 - 0.17 12.4 0.1 0.17 12.4 0.1 3.1 3 0 0 3 3 2 0 ABC transporter DUF5339 PF17274.2 EFA75586.1 - 0.21 12.5 6.0 0.79 10.6 0.2 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5339) NPV_P10 PF05531.12 EFA75586.1 - 0.29 11.6 5.7 0.19 12.2 0.3 3.4 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein P4Ha_N PF08336.11 EFA75586.1 - 0.38 10.8 8.0 0.065 13.3 0.7 3.3 3 0 0 3 3 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF883 PF05957.13 EFA75586.1 - 0.56 10.8 1.7 11 6.8 0.1 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) RPW8 PF05659.11 EFA75586.1 - 0.59 9.8 9.2 0.081 12.6 1.3 3.4 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ATP_bind_1 PF03029.17 EFA75586.1 - 0.7 9.6 4.0 1.2 8.9 0.1 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF4041 PF13250.6 EFA75586.1 - 0.79 9.6 4.9 0.6 10.0 0.1 3.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4041) ABC_tran_CTD PF16326.5 EFA75586.1 - 0.94 9.8 10.2 0.23 11.7 2.2 3.6 3 1 1 4 4 4 0 ABC transporter C-terminal domain Dynamin_N PF00350.23 EFA75586.1 - 2.1 8.4 18.3 1.2 9.2 0.1 4.7 5 1 0 5 5 4 0 Dynamin family TMPIT PF07851.13 EFA75586.1 - 2.8 7.1 20.7 0.037 13.3 7.4 3.0 2 1 1 3 3 3 0 TMPIT-like protein DUF842 PF05811.13 EFA75586.1 - 6.2 6.5 11.6 1.6 8.4 2.2 3.5 3 1 1 4 4 4 0 Eukaryotic protein of unknown function (DUF842) PHM7_cyt PF14703.6 EFA75586.1 - 7 6.9 9.2 0.63 10.3 1.9 2.6 3 0 0 3 3 2 0 Cytosolic domain of 10TM putative phosphate transporter CCDC-167 PF15188.6 EFA75586.1 - 8.6 6.8 9.7 1.1 9.7 0.4 3.3 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Med9 PF07544.13 EFA75586.1 - 8.8 6.5 10.8 11 6.2 0.2 3.7 4 1 0 4 4 2 0 RNA polymerase II transcription mediator complex subunit 9 ACCA PF03255.14 EFA75586.1 - 9.2 6.1 8.2 3.2 7.6 1.5 2.8 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit WXG100 PF06013.12 EFA75587.1 - 0.32 11.3 2.8 13 6.1 0.0 3.1 4 1 0 4 4 4 0 Proteins of 100 residues with WXG DUF1599 PF07659.11 EFA75587.1 - 1.4 9.4 4.1 22 5.6 0.6 3.0 3 0 0 3 3 3 0 Nucleotide modification associated domain 1 AAA_23 PF13476.6 EFA75587.1 - 8.2 6.9 16.7 0.82 10.1 9.5 2.5 3 0 0 3 3 3 0 AAA domain AIG1 PF04548.16 EFA75588.1 - 2.7e-07 30.1 1.8 2.7e-07 30.1 1.8 2.0 1 1 0 2 2 2 1 AIG1 family AAA_10 PF12846.7 EFA75588.1 - 5.8e-05 22.2 0.1 9.3e-05 21.5 0.1 1.4 1 1 0 1 1 1 1 AAA-like domain Septin PF00735.18 EFA75588.1 - 8.9e-05 21.9 0.6 0.00025 20.4 0.2 1.9 1 1 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EFA75588.1 - 0.00017 21.6 1.5 0.0016 18.5 0.8 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EFA75588.1 - 0.0043 16.6 0.1 0.01 15.4 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 EFA75588.1 - 0.0089 15.1 0.0 0.015 14.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 EFA75588.1 - 0.012 15.4 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFA75588.1 - 0.013 14.9 0.8 0.028 13.8 0.1 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Sigma54_activ_2 PF14532.6 EFA75588.1 - 0.013 15.6 0.0 4.7 7.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFA75588.1 - 0.019 14.3 0.0 0.044 13.2 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 EFA75588.1 - 0.039 13.9 0.4 0.13 12.1 0.1 2.0 1 1 1 2 2 2 0 RsgA GTPase NTPase_P4 PF11602.8 EFA75588.1 - 0.055 12.7 0.2 8.8 5.4 0.1 2.3 2 0 0 2 2 2 0 ATPase P4 of dsRNA bacteriophage phi-12 DUF3303 PF11746.8 EFA75588.1 - 0.066 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3303) Zeta_toxin PF06414.12 EFA75588.1 - 0.075 12.3 0.0 1.3 8.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.12 EFA75588.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 NACHT domain ResIII PF04851.15 EFA75588.1 - 0.086 12.8 0.8 0.12 12.4 0.1 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PduV-EutP PF10662.9 EFA75588.1 - 0.17 11.7 2.0 11 5.8 0.1 2.9 2 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EFA75588.1 - 1.6 9.3 6.7 5 7.6 6.7 2.3 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 EFA75588.1 - 3.2 8.2 6.6 12 6.4 6.6 2.1 1 1 0 1 1 1 0 AAA domain TrkA_N PF02254.18 EFA75590.1 - 0.074 13.3 0.1 0.24 11.7 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain Ank_2 PF12796.7 EFA75591.1 - 7.5e-24 84.1 4.2 5e-07 30.2 0.1 5.3 3 2 3 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75591.1 - 5.9e-16 58.6 4.4 0.00045 20.7 0.0 6.7 5 1 4 9 9 9 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75591.1 - 3.7e-13 49.4 0.1 0.00013 22.2 0.0 7.7 5 1 3 8 8 8 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75591.1 - 5.7e-10 38.6 0.9 15 6.6 0.0 8.2 8 0 0 8 8 8 2 Ankyrin repeat Thioredoxin PF00085.20 EFA75591.1 - 0.00026 20.9 0.0 0.00058 19.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Mitoc_mL59 PF18126.1 EFA75592.1 - 0.015 15.6 7.4 0.11 12.8 4.1 2.6 1 1 1 2 2 2 0 Mitochondrial ribosomal protein mL59 DUF3290 PF11694.8 EFA75592.1 - 0.24 11.4 0.2 0.24 11.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) RNB PF00773.19 EFA75593.1 - 1.1e-30 107.1 3.1 1.1e-30 107.1 3.1 4.2 2 1 1 3 3 3 2 RNB domain Insulin_TMD PF17870.1 EFA75593.1 - 0.027 14.5 0.1 0.083 13.0 0.1 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment EMC3_TMCO1 PF01956.16 EFA75593.1 - 0.032 14.0 1.5 0.26 11.0 0.0 2.6 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like LELP1 PF15042.6 EFA75593.1 - 0.13 12.7 0.2 0.26 11.7 0.2 1.4 1 0 0 1 1 1 0 Late cornified envelope-like proline-rich protein 1 EB PF01683.18 EFA75594.1 - 0.0036 17.6 8.5 0.0036 17.6 8.5 6.5 1 1 4 5 5 5 3 EB module SdrD_B PF17210.3 EFA75595.1 - 2e-19 69.9 0.3 1.8e-12 47.4 0.1 2.5 2 1 0 2 2 2 2 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA75595.1 - 2e-08 34.4 0.0 1.4e-05 25.3 0.0 2.6 2 1 0 2 2 2 2 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA75595.1 - 9.6e-07 29.1 0.5 0.006 16.9 0.1 2.6 2 1 0 2 2 2 2 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA75595.1 - 0.0019 18.2 0.4 0.32 11.0 0.0 3.4 2 1 1 3 3 3 1 CarboxypepD_reg-like domain DUF2606 PF10794.9 EFA75595.1 - 0.015 15.1 0.0 0.15 11.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2606) EMP24_GP25L PF01105.24 EFA75595.1 - 0.017 15.1 0.1 0.67 9.9 0.0 2.2 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF2012 PF09430.10 EFA75595.1 - 0.029 14.5 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) DUF3244 PF11589.8 EFA75595.1 - 0.03 14.4 0.2 0.41 10.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3244) EB PF01683.18 EFA75596.1 - 0.0036 17.5 13.5 0.0036 17.5 13.5 7.0 1 1 5 6 6 6 3 EB module Ank_2 PF12796.7 EFA75597.1 - 5.2e-19 68.6 1.8 2.2e-06 28.2 0.1 5.4 5 1 2 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75597.1 - 4.1e-17 62.3 4.6 0.00073 20.0 0.0 8.0 5 2 3 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75597.1 - 2.4e-14 53.2 0.8 0.007 16.7 0.1 7.0 5 2 3 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75597.1 - 1.2e-13 49.8 3.2 0.05 14.2 0.0 9.3 12 0 0 12 12 12 3 Ankyrin repeat DUF3447 PF11929.8 EFA75597.1 - 0.0046 16.9 34.6 0.16 11.9 0.9 6.6 3 2 4 7 7 7 4 Domain of unknown function (DUF3447) E7R PF17467.2 EFA75597.1 - 0.021 15.0 1.0 0.2 11.8 0.1 3.0 3 0 0 3 3 3 0 Viral Protein E7 Ank PF00023.30 EFA75597.1 - 0.038 14.4 0.0 1.2 9.7 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat Roughex PF06020.11 EFA75598.1 - 0.013 14.7 1.4 0.022 13.9 1.4 1.4 1 0 0 1 1 1 0 Drosophila roughex protein ASD2 PF08687.11 EFA75598.1 - 0.46 10.0 9.8 6 6.3 8.2 2.2 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Hydin_ADK PF17213.3 EFA75598.1 - 0.66 10.2 6.1 1.4 9.1 6.1 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Zip PF02535.22 EFA75598.1 - 1.3 8.2 3.1 1.5 8.0 3.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EFA75598.1 - 3.3 6.4 12.2 4.9 5.8 12.2 1.2 1 0 0 1 1 1 0 Presenilin PCNA_N PF00705.18 EFA75600.1 - 1.1e-49 167.4 0.4 8.3e-49 164.5 0.1 2.2 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EFA75600.1 - 5.4e-48 162.4 0.1 1e-47 161.5 0.1 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EFA75600.1 - 2.3e-10 40.0 0.8 4.2e-09 35.9 0.8 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 ZapB PF06005.12 EFA75601.1 - 0.041 14.3 0.5 0.13 12.7 0.5 1.8 1 0 0 1 1 1 0 Cell division protein ZapB Ank_2 PF12796.7 EFA75602.1 - 7.9e-20 71.2 12.3 6e-07 30.0 0.4 5.0 2 1 5 7 7 7 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75602.1 - 1.4e-16 60.3 7.9 6.4e-05 23.1 0.1 7.4 5 2 5 10 10 10 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75602.1 - 1.7e-14 54.0 11.8 0.00019 22.0 0.2 7.3 3 2 6 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75602.1 - 1.9e-09 37.0 7.3 1.8 9.4 0.0 8.8 10 0 0 10 10 10 2 Ankyrin repeat Ank PF00023.30 EFA75602.1 - 5.4e-05 23.4 0.0 13 6.4 0.0 5.3 5 1 0 5 5 5 1 Ankyrin repeat Actin PF00022.19 EFA75603.1 - 3.2e-129 431.1 0.0 2.1e-128 428.4 0.0 1.8 1 1 0 1 1 1 1 Actin PSDC PF12588.8 EFA75603.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Phophatidylserine decarboxylase DUF3402 PF11882.8 EFA75604.1 - 6.3e-58 197.0 28.9 1.5e-32 113.3 7.8 3.2 2 1 1 3 3 3 3 Domain of unknown function (DUF3402) N1221 PF07923.13 EFA75604.1 - 4.2e-32 111.5 7.0 4.2e-32 111.5 7.0 2.3 2 1 0 2 2 2 1 N1221-like protein SUIM_assoc PF16619.5 EFA75604.1 - 4.3 7.5 19.1 3.7 7.7 0.5 3.7 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF966 PF06136.13 EFA75605.1 - 0.2 11.4 31.4 0.31 10.7 31.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) AF-4 PF05110.13 EFA75605.1 - 2.4 6.2 57.4 2.7 6.0 57.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein LAP1C PF05609.12 EFA75605.1 - 4 6.4 38.6 5.5 6.0 38.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Red1 PF07964.11 EFA75605.1 - 5.9 5.0 60.7 7.4 4.7 60.7 1.2 1 0 0 1 1 1 0 Rec10 / Red1 Ank_2 PF12796.7 EFA75606.1 - 1.5e-38 131.2 0.2 6.1e-14 52.4 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 EFA75606.1 - 2.6e-29 102.0 11.6 2.6e-29 102.0 11.6 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.6 EFA75606.1 - 1.3e-28 99.0 5.8 1.7e-07 31.7 0.1 5.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75606.1 - 3.9e-22 78.0 7.3 1.8e-08 34.5 0.0 5.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75606.1 - 1.1e-21 74.6 0.1 3.2e-06 27.1 0.0 6.2 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFA75606.1 - 4e-20 71.3 0.2 2.4e-07 30.9 0.0 6.0 4 1 1 5 5 5 3 Ankyrin repeat PBP1_TM PF14812.6 EFA75606.1 - 0.97 9.8 20.6 0.14 12.6 5.0 2.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 EFA75606.1 - 1.6 7.9 8.9 0.53 9.5 5.9 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Macoilin PF09726.9 EFA75606.1 - 5.6 5.4 9.8 7.7 4.9 9.8 1.1 1 0 0 1 1 1 0 Macoilin family Spt5_N PF11942.8 EFA75606.1 - 6.9 7.7 12.1 21 6.2 0.4 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal PLAC8 PF04749.17 EFA75607.1 - 1.3e-10 42.2 31.0 1.3e-10 42.2 31.0 2.9 2 1 0 2 2 2 1 PLAC8 family Syntaxin_2 PF14523.6 EFA75608.1 - 4.1e-20 72.0 6.9 4.1e-20 72.0 6.9 3.3 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EFA75608.1 - 1.9e-12 47.0 0.1 4.1e-12 45.9 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EFA75608.1 - 0.0013 18.4 24.0 0.025 14.3 14.8 3.2 1 1 1 2 2 2 1 Syntaxin TFIIA PF03153.13 EFA75608.1 - 2.3 8.1 27.6 3.1 7.7 27.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1644 PF07800.12 EFA75608.1 - 4.1 7.4 10.8 58 3.7 10.9 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) Bestrophin PF01062.21 EFA75608.1 - 8.7 5.6 6.3 4.5 6.6 1.9 2.2 2 1 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel SelR PF01641.18 EFA75609.1 - 5.4e-50 168.5 0.9 8.2e-50 167.9 0.9 1.3 1 0 0 1 1 1 1 SelR domain SUIM_assoc PF16619.5 EFA75609.1 - 0.0025 17.8 2.6 0.004 17.2 2.6 1.6 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Yippee-Mis18 PF03226.14 EFA75609.1 - 0.0063 16.7 3.0 0.021 15.0 3.0 1.9 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly FtsX PF02687.21 EFA75610.1 - 0.04 14.4 1.8 0.95 10.0 0.2 2.2 2 0 0 2 2 2 0 FtsX-like permease family DUF4282 PF14110.6 EFA75610.1 - 0.05 14.3 3.3 0.071 13.9 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) PdaC PF13739.6 EFA75610.1 - 2.4 9.2 6.0 4.3 8.4 0.7 2.8 2 1 1 3 3 3 0 Deacetylase PdaC TAP42 PF04177.12 EFA75612.1 - 1.4e-75 254.4 3.8 1.7e-75 254.1 3.8 1.0 1 0 0 1 1 1 1 TAP42-like family ACOX PF01756.19 EFA75614.1 - 9e-17 61.2 0.0 1.6e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFA75614.1 - 2.1e-15 56.7 0.0 3.7e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EFA75614.1 - 9e-09 36.0 0.0 1.6e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EFA75614.1 - 2.5e-06 27.8 0.0 6.1e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFA75614.1 - 0.15 12.7 0.0 0.36 11.5 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain Myotub-related PF06602.14 EFA75615.1 - 1.9e-134 448.1 1.6 1.9e-134 448.1 1.6 1.8 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain PX PF00787.24 EFA75615.1 - 1.3e-16 60.6 0.6 5.8e-16 58.5 0.6 2.2 1 0 0 1 1 1 1 PX domain PH PF00169.29 EFA75615.1 - 3.8e-10 40.2 1.4 3.8e-10 40.2 1.4 3.5 3 0 0 3 3 3 1 PH domain Y_phosphatase3 PF13350.6 EFA75615.1 - 0.0009 19.3 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EFA75615.1 - 0.0059 16.4 0.1 0.0059 16.4 0.1 4.2 5 0 0 5 5 5 1 Dual specificity phosphatase, catalytic domain GRAM PF02893.20 EFA75615.1 - 0.015 15.2 1.2 0.1 12.5 0.1 2.9 2 0 0 2 2 2 0 GRAM domain PH_9 PF15410.6 EFA75615.1 - 0.082 13.3 6.1 0.39 11.1 3.4 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 EFA75615.1 - 5.1 7.6 15.2 0.22 11.9 2.6 4.2 3 0 0 3 3 3 0 Pleckstrin homology domain SYF2 PF08231.12 EFA75616.1 - 1e-25 91.0 19.4 1e-25 91.0 19.4 2.2 1 1 1 2 2 2 1 SYF2 splicing factor Tyr-DNA_phospho PF06087.12 EFA75617.1 - 5.7e-55 186.9 9.9 4.3e-38 131.3 0.1 3.2 3 1 1 4 4 4 2 Tyrosyl-DNA phosphodiesterase Mito_carr PF00153.27 EFA75618.1 - 2.5e-64 213.2 5.5 2.8e-22 78.5 0.4 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase_Tyr PF07714.17 EFA75619.1 - 1.8e-37 129.0 0.0 3.4e-37 128.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75619.1 - 2.4e-29 102.5 0.0 5.7e-29 101.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Arm PF00514.23 EFA75619.1 - 1.6e-12 47.0 22.6 0.15 12.2 0.0 10.4 10 0 0 10 10 10 5 Armadillo/beta-catenin-like repeat LRR_4 PF12799.7 EFA75619.1 - 1.3e-09 38.2 21.2 1.5e-05 25.2 1.5 6.3 3 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA75619.1 - 0.0006 19.5 19.9 0.014 15.1 2.4 4.8 2 1 3 5 5 5 3 Leucine rich repeat LRR_9 PF14580.6 EFA75619.1 - 0.0031 17.0 14.7 0.0097 15.4 1.6 4.4 3 1 1 4 4 4 2 Leucine-rich repeat Kinase-like PF14531.6 EFA75619.1 - 0.0038 16.6 0.0 0.0078 15.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like HEAT_2 PF13646.6 EFA75619.1 - 0.0066 16.8 0.0 35 4.9 0.0 4.8 3 2 2 5 5 5 0 HEAT repeats Mod_r PF07200.13 EFA75619.1 - 0.51 10.4 6.4 1 9.4 0.5 3.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein adh_short PF00106.25 EFA75620.1 - 2.3e-42 144.6 0.9 2.8e-42 144.4 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA75620.1 - 1.3e-27 96.9 0.0 1.6e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA75620.1 - 5.7e-09 36.1 0.1 1.3e-08 34.9 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA75620.1 - 0.0035 16.8 0.1 0.0086 15.6 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SIN1_PH PF16979.5 EFA75621.1 - 6.9e-12 45.6 0.6 6.9e-12 45.6 0.6 2.0 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology CRIM PF16978.5 EFA75621.1 - 2.9e-11 43.7 0.0 8.2e-11 42.2 0.0 1.9 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain RBD PF02196.15 EFA75621.1 - 5.9e-07 29.5 0.1 1.6e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain Hamartin PF04388.12 EFA75621.1 - 8.7 4.9 27.9 16 4.0 27.9 1.4 1 0 0 1 1 1 0 Hamartin protein MR_MLE_C PF13378.6 EFA75622.1 - 2.8e-15 56.5 0.0 6.9e-15 55.2 0.0 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFA75622.1 - 9.7e-05 22.6 0.0 0.38 11.0 0.0 2.5 2 0 0 2 2 2 2 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain CotJB PF12652.7 EFA75622.1 - 0.056 13.7 0.2 1.3 9.3 0.1 2.5 2 0 0 2 2 2 0 CotJB protein EF-hand_7 PF13499.6 EFA75623.1 - 8.4e-12 45.4 2.6 1.4e-05 25.4 1.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA75623.1 - 2.9e-11 42.3 8.2 4.9e-05 22.9 0.2 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EFA75623.1 - 5e-11 41.3 8.4 1.9e-05 23.9 0.4 4.0 3 1 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFA75623.1 - 3.9e-08 33.0 5.2 0.0024 17.7 1.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFA75623.1 - 7e-05 22.1 8.2 0.0014 18.0 0.3 4.0 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 EFA75623.1 - 0.00011 22.5 2.2 0.26 11.6 0.6 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFA75623.1 - 0.092 12.7 2.7 0.12 12.3 0.6 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 EFA75623.1 - 0.21 12.4 4.5 3.2 8.7 1.2 2.8 1 1 2 3 3 3 0 EF-hand domain PLDc_2 PF13091.6 EFA75624.1 - 4.6e-38 130.1 0.0 4.9e-23 81.5 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFA75624.1 - 6.5e-09 35.6 2.2 7.6e-06 25.9 0.1 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif ArfGap PF01412.18 EFA75624.1 - 0.12 12.4 0.8 2.5 8.2 0.0 2.8 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Barttin PF15462.6 EFA75624.1 - 1.2 8.9 4.3 2.3 7.9 4.3 1.5 1 1 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) YL1 PF05764.13 EFA75624.1 - 1.7 8.7 8.1 3.3 7.8 8.1 1.4 1 0 0 1 1 1 0 YL1 nuclear protein DnaJ PF00226.31 EFA75625.1 - 1.7e-17 63.3 0.2 3.3e-17 62.4 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain Mito_carr PF00153.27 EFA75625.1 - 7.1e-10 38.7 0.6 0.0036 17.2 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Ank_2 PF12796.7 EFA75626.1 - 5.1e-31 107.1 9.3 2.1e-07 31.4 1.1 6.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75626.1 - 9.8e-23 80.2 8.4 0.032 14.8 0.0 10.1 4 3 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75626.1 - 5.3e-18 64.8 8.3 0.11 12.9 0.1 10.5 5 3 7 12 12 12 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75626.1 - 8.4e-16 56.5 6.9 3.5 8.5 0.1 12.1 11 2 2 13 13 13 2 Ankyrin repeat DUF3447 PF11929.8 EFA75626.1 - 0.0039 17.1 19.2 1.1 9.3 2.2 6.5 2 1 3 7 7 7 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA75626.1 - 0.49 10.9 2.1 2.1e+02 2.6 0.0 5.4 8 3 0 8 8 8 0 Ankyrin repeat LSM PF01423.22 EFA75627.1 - 1.2e-17 63.3 0.4 1.8e-17 62.8 0.4 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA75627.1 - 0.00027 21.0 0.0 0.00037 20.6 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Feld-I_B PF09252.10 EFA75627.1 - 0.15 12.1 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Allergen Fel d I-B chain Prenylcys_lyase PF07156.14 EFA75628.1 - 2.5e-69 234.1 5.4 3.2e-69 233.8 5.4 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EFA75628.1 - 8.4e-15 55.0 0.0 1.2e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA75628.1 - 3.1e-12 46.6 0.1 5.9e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA75628.1 - 1.5e-06 28.0 0.3 6.5e-06 26.0 0.4 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFA75628.1 - 1.6e-06 27.6 0.2 0.00085 18.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFA75628.1 - 3.4e-06 27.1 0.2 0.0019 18.2 0.1 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 EFA75628.1 - 0.0015 17.7 0.1 0.61 9.2 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 EFA75628.1 - 0.0039 16.1 0.0 0.007 15.3 0.0 1.5 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.17 EFA75628.1 - 0.0067 15.7 0.1 0.05 12.8 0.0 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EFA75628.1 - 0.031 14.8 0.3 0.088 13.4 0.3 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SIS PF01380.22 EFA75629.1 - 1.9e-38 131.3 5.2 3.2e-22 78.8 0.3 2.7 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 EFA75629.1 - 5.3e-21 75.2 0.3 1.1e-20 74.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EFA75629.1 - 1.1e-15 57.6 0.0 2.9e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain bact-PGI_C PF10432.9 EFA75629.1 - 0.0031 17.5 0.1 0.097 12.7 0.0 3.2 3 1 0 3 3 3 1 Bacterial phospho-glucose isomerase C-terminal SIS domain GATase_4 PF13230.6 EFA75629.1 - 0.0091 14.9 0.5 0.11 11.3 0.2 2.2 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Hep_59 PF07052.11 EFA75630.1 - 1.1e-22 80.7 12.0 1.1e-22 80.7 12.0 3.8 3 1 1 4 4 4 1 Hepatocellular carcinoma-associated antigen 59 DLH PF01738.18 EFA75630.1 - 3.4 7.2 5.5 4.8 6.7 0.3 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family Homoserine_dh PF00742.19 EFA75631.1 - 1.5e-49 168.3 0.6 1.1e-48 165.5 0.0 2.4 2 1 0 2 2 2 1 Homoserine dehydrogenase AA_kinase PF00696.28 EFA75631.1 - 2e-41 142.2 0.0 4.1e-41 141.2 0.0 1.6 1 0 0 1 1 1 1 Amino acid kinase family NAD_binding_3 PF03447.16 EFA75631.1 - 2.9e-17 63.4 0.0 1.2e-16 61.4 0.0 2.1 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain ACT_7 PF13840.6 EFA75631.1 - 2.1e-10 40.2 3.5 2.3e-05 24.1 0.3 2.9 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 EFA75631.1 - 1.2e-09 37.8 0.8 4.8e-05 23.1 0.1 2.8 2 0 0 2 2 2 2 ACT domain DDE_1 PF03184.19 EFA75632.1 - 4.1e-12 46.1 0.6 1.2e-11 44.6 0.6 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 EFA75632.1 - 0.0018 18.0 0.0 0.0037 17.0 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_19 PF12844.7 EFA75632.1 - 0.0097 15.9 1.3 0.089 12.8 0.4 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 EFA75632.1 - 0.032 14.3 0.1 0.27 11.3 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix HTH_37 PF13744.6 EFA75632.1 - 0.054 13.5 0.1 0.054 13.5 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 EFA75632.1 - 0.096 12.3 0.0 0.78 9.4 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Pkinase PF00069.25 EFA75633.1 - 8.1e-68 228.6 3.0 9.4e-68 228.4 0.3 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75633.1 - 7.7e-45 153.2 0.1 7.7e-45 153.2 0.1 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase Amino_oxidase PF01593.24 EFA75633.1 - 2.1e-42 146.0 0.0 1.1e-39 137.0 0.0 2.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase CorA PF01544.18 EFA75633.1 - 8.3e-36 123.8 2.9 8.3e-36 123.8 2.9 4.4 3 1 1 4 4 2 2 CorA-like Mg2+ transporter protein NAD_binding_8 PF13450.6 EFA75633.1 - 7.5e-08 32.5 0.2 1.7e-07 31.3 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFA75633.1 - 1.5e-05 24.3 0.0 2.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 EFA75633.1 - 0.001 18.5 0.2 0.001 18.5 0.2 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFA75633.1 - 0.0024 17.0 0.0 0.0036 16.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFA75633.1 - 0.006 15.3 0.0 0.015 14.1 0.0 1.7 1 0 0 1 1 1 1 HI0933-like protein Kinase-like PF14531.6 EFA75633.1 - 0.0067 15.8 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FAD_binding_3 PF01494.19 EFA75633.1 - 0.029 13.6 0.2 0.054 12.7 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EFA75633.1 - 0.034 13.7 0.0 0.05 13.2 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFA75633.1 - 0.087 11.9 0.1 0.087 11.9 0.1 2.5 3 0 0 3 3 2 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EFA75633.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GATA PF00320.27 EFA75635.1 - 5.2e-16 58.0 5.2 9.9e-16 57.1 5.2 1.5 1 0 0 1 1 1 1 GATA zinc finger PhoPQ_related PF10142.9 EFA75636.1 - 1.3e-132 441.9 3.1 1.9e-132 441.3 3.1 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Myb_DNA-binding PF00249.31 EFA75637.1 - 2.9e-31 107.4 19.3 1.6e-16 60.2 1.5 3.8 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA75637.1 - 5.8e-29 100.1 5.9 3.5e-15 56.0 0.3 4.3 3 1 1 4 4 4 3 Myb-like DNA-binding domain SLIDE PF09111.10 EFA75637.1 - 0.0012 18.9 6.2 0.21 11.6 0.0 3.3 3 1 0 3 3 3 2 SLIDE SANT_DAMP1_like PF16282.5 EFA75637.1 - 0.0014 18.7 1.6 1.9 8.7 0.0 3.2 2 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_4 PF13837.6 EFA75637.1 - 0.016 15.6 14.3 0.25 11.7 1.6 3.9 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain Atg29_N PF18388.1 EFA75637.1 - 0.12 12.3 8.9 1.3 8.9 0.3 3.5 3 0 0 3 3 3 0 Atg29 N-terminal domain MADF_DNA_bdg PF10545.9 EFA75637.1 - 0.14 12.5 14.8 2.2 8.7 2.4 4.4 4 1 1 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.6 EFA75637.1 - 1.2 9.3 7.7 56 3.9 0.0 4.6 4 2 0 4 4 4 0 Myb/SANT-like DNA-binding domain PLDc_2 PF13091.6 EFA75638.1 - 2.6e-25 88.8 0.3 5.7e-19 68.3 0.0 2.7 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFA75638.1 - 7.3e-08 32.3 6.4 0.00014 21.9 0.3 3.1 3 0 0 3 3 3 2 Phospholipase D Active site motif Collectrin PF16959.5 EFA75639.1 - 0.054 13.3 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 Renal amino acid transporter Glyco_hydro_43 PF04616.14 EFA75639.1 - 0.14 11.5 0.2 0.34 10.2 0.2 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 43 Merozoite_SPAM PF07133.11 EFA75640.1 - 0.00059 19.9 30.6 0.00059 19.9 30.6 6.3 7 0 0 7 7 7 1 Merozoite surface protein (SPAM) zf-C2H2_9 PF16293.5 EFA75641.1 - 0.76 9.7 9.1 0.75 9.7 1.0 3.7 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) GyrI-like PF06445.15 EFA75642.1 - 4.1e-20 72.6 0.6 4.6e-20 72.5 0.6 1.0 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 EFA75642.1 - 0.0069 16.5 1.1 0.0096 16.1 1.1 1.4 1 1 0 1 1 1 1 Integron-associated effector binding protein TcpA PF05946.12 EFA75642.1 - 0.2 11.7 0.0 0.28 11.3 0.0 1.1 1 0 0 1 1 1 0 Toxin-coregulated pilus subunit TcpA GyrI-like PF06445.15 EFA75643.1 - 1.7e-15 57.7 0.0 2e-15 57.4 0.0 1.0 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 EFA75643.1 - 0.00035 20.7 0.0 0.00051 20.2 0.0 1.2 1 0 0 1 1 1 1 Integron-associated effector binding protein Ank_2 PF12796.7 EFA75644.1 - 5.1e-13 49.4 2.4 2.1e-05 25.0 0.0 6.1 5 1 1 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75644.1 - 2.5e-09 37.5 6.1 0.012 16.2 0.0 7.4 7 3 1 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75644.1 - 0.00051 20.3 8.7 1.6e+02 3.4 0.0 9.2 12 0 0 12 12 12 0 Ankyrin repeat Ank_5 PF13857.6 EFA75644.1 - 0.0051 17.1 6.9 20 5.6 0.0 6.2 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75645.1 - 2.2e-05 25.0 1.2 7.1 7.3 0.0 5.1 4 2 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75645.1 - 0.0054 17.1 1.2 1.2e+02 3.7 0.0 5.7 6 0 0 6 6 6 0 Ankyrin repeat DUF4393 PF14337.6 EFA75645.1 - 0.21 11.4 4.2 0.069 12.9 1.0 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4393) Ank_2 PF12796.7 EFA75646.1 - 1.1e-25 90.0 13.8 6.9e-09 36.2 0.1 5.5 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75646.1 - 1.5e-18 64.9 4.0 0.049 14.2 0.0 10.2 9 1 1 10 10 10 3 Ankyrin repeat Ank_4 PF13637.6 EFA75646.1 - 1.3e-16 60.7 12.2 0.015 15.9 0.1 9.2 7 3 4 11 11 11 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75646.1 - 6.1e-16 58.3 6.5 0.0074 16.6 0.0 7.7 6 2 2 9 9 9 4 Ankyrin repeats (many copies) Ank PF00023.30 EFA75646.1 - 0.00014 22.2 1.7 10 6.7 0.0 5.6 5 0 0 5 5 5 1 Ankyrin repeat DUF1619 PF07773.11 EFA75646.1 - 0.00054 20.0 1.5 0.001 19.1 1.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1619) FBD PF08387.10 EFA75646.1 - 0.05 13.5 6.0 0.68 9.9 0.1 5.1 7 1 0 7 7 7 0 FBD DUF5049 PF16468.5 EFA75646.1 - 0.068 13.1 1.2 4.2 7.3 0.0 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF5049) FNIP PF05725.12 EFA75647.1 - 1.8e-19 69.6 54.1 5.4e-09 36.1 0.4 10.3 11 2 1 12 12 12 5 FNIP Repeat F-box_5 PF18511.1 EFA75647.1 - 0.00049 19.6 0.1 0.001 18.6 0.1 1.4 1 0 0 1 1 1 1 F-box Mob1_phocein PF03637.17 EFA75648.1 - 8.8e-35 120.2 0.5 1e-34 120.0 0.5 1.1 1 0 0 1 1 1 1 Mob1/phocein family Kinetochor_Ybp2 PF08568.10 EFA75649.1 - 2.3e-23 82.6 0.4 8.1e-16 57.6 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin DUF1980 PF09323.10 EFA75649.1 - 0.016 15.1 0.1 0.04 13.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) TFIIA PF03153.13 EFA75649.1 - 0.24 11.4 15.2 1.7 8.6 4.4 2.3 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Afi1 PF07792.12 EFA75649.1 - 1.7 9.2 13.9 2.8 8.4 0.7 3.0 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SnoaL_2 PF12680.7 EFA75650.1 - 0.0061 17.2 0.0 0.0082 16.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain Arm_APC_u3 PF16629.5 EFA75650.1 - 0.011 15.4 0.7 0.014 15.0 0.7 1.1 1 0 0 1 1 1 0 Armadillo-associated region on APC Acyl-CoA_dh_1 PF00441.24 EFA75651.1 - 5e-25 88.5 0.0 1.5e-24 86.9 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 EFA75651.1 - 5.9e-20 71.8 0.0 9.3e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 EFA75651.1 - 6.9e-12 45.4 0.1 1.6e-11 44.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFA75651.1 - 1.9e-08 34.6 0.0 4.5e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_C PF12806.7 EFA75651.1 - 0.035 14.3 0.1 0.065 13.4 0.1 1.4 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like Proteasome PF00227.26 EFA75654.1 - 1.2e-62 210.8 0.0 1.4e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA75654.1 - 3.1e-13 49.1 0.3 5.6e-13 48.3 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ank_2 PF12796.7 EFA75656.1 - 5.8e-23 81.3 8.6 9.7e-07 29.3 0.2 6.2 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75656.1 - 2.1e-18 66.4 2.8 0.0085 16.7 0.0 8.8 4 3 6 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75656.1 - 1.4e-13 49.7 5.5 0.044 14.3 0.0 9.9 11 2 2 13 13 13 3 Ankyrin repeat Ank_5 PF13857.6 EFA75656.1 - 1.6e-09 37.9 0.5 0.0052 17.1 0.1 6.8 5 2 2 8 8 8 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA75656.1 - 0.0015 18.9 0.3 5.3 7.7 0.0 5.4 6 1 0 6 6 6 1 Ankyrin repeat DUF4116 PF13475.6 EFA75656.1 - 0.01 15.6 3.1 6.1 6.7 0.0 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF4116) DUF5049 PF16468.5 EFA75656.1 - 0.026 14.4 1.4 8.8 6.3 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF5049) Helicase_RecD PF05127.14 EFA75656.1 - 0.05 13.4 0.2 0.11 12.4 0.2 1.7 1 0 0 1 1 1 0 Helicase FBD PF08387.10 EFA75656.1 - 0.075 12.9 2.0 13 5.7 0.0 4.2 5 0 0 5 5 5 0 FBD ENTH PF01417.20 EFA75656.1 - 0.24 11.4 13.3 12 6.0 0.1 5.8 3 1 1 5 5 5 0 ENTH domain Met_10 PF02475.16 EFA75656.1 - 0.51 10.1 4.9 8 6.2 0.8 3.5 3 1 0 3 3 3 0 Met-10+ like-protein Ank_5 PF13857.6 EFA75657.1 - 6.7e-09 35.8 0.4 0.00018 21.8 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75657.1 - 1.2e-07 32.2 0.1 0.0058 17.2 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75657.1 - 1.2e-06 28.9 0.1 0.0061 17.1 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75657.1 - 1.6e-06 28.0 0.1 0.014 15.8 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFA75657.1 - 0.0022 18.4 0.0 3.9 8.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat FNIP PF05725.12 EFA75659.1 - 5.2e-21 74.5 55.4 4.3e-12 46.0 2.4 11.9 8 4 3 12 12 12 6 FNIP Repeat F-box_5 PF18511.1 EFA75659.1 - 1.4e-07 31.0 0.6 3.1e-07 29.8 0.6 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75659.1 - 0.0067 16.3 0.2 0.027 14.4 0.2 2.0 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EFA75659.1 - 0.058 13.5 0.5 5.4 7.3 0.1 4.0 3 0 0 3 3 3 0 Leucine Rich repeat Peptidase_M4 PF01447.18 EFA75659.1 - 0.067 13.7 1.1 0.15 12.6 1.1 1.5 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain F-box PF00646.33 EFA75659.1 - 0.11 12.5 0.2 0.49 10.3 0.2 2.2 1 0 0 1 1 1 0 F-box domain Ras PF00071.22 EFA75660.1 - 1.3e-47 161.4 0.0 1.5e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75660.1 - 9.8e-29 100.0 0.0 1.4e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75660.1 - 2.7e-11 43.2 0.0 3.5e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA75660.1 - 0.0011 18.3 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA75660.1 - 0.11 11.7 0.0 3.6 6.6 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 EFA75660.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 EFA75660.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Mid domain of argonaute FNIP PF05725.12 EFA75661.1 - 4.6e-19 68.3 6.5 6.2e-09 35.9 0.1 8.8 8 2 2 10 10 10 3 FNIP Repeat F-box_5 PF18511.1 EFA75661.1 - 0.00042 19.8 0.1 0.00092 18.7 0.1 1.5 1 0 0 1 1 1 1 F-box Ras PF00071.22 EFA75662.1 - 1.3e-47 161.4 0.0 1.5e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA75662.1 - 9.8e-29 100.0 0.0 1.4e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75662.1 - 2.7e-11 43.2 0.0 3.5e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA75662.1 - 0.0011 18.3 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA75662.1 - 0.11 11.7 0.0 3.6 6.6 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 EFA75662.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 EFA75662.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Mid domain of argonaute FNIP PF05725.12 EFA75663.1 - 2 8.6 7.4 1.9 8.7 1.3 2.6 1 1 0 2 2 2 0 FNIP Repeat FNIP PF05725.12 EFA75664.1 - 3.4e-24 84.7 18.6 9.7e-08 32.1 0.5 9.4 6 3 7 13 13 13 6 FNIP Repeat F-box_5 PF18511.1 EFA75664.1 - 1e-05 25.0 0.5 2.4e-05 23.8 0.5 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75664.1 - 0.029 14.2 1.6 0.046 13.6 0.4 2.0 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 EFA75664.1 - 0.049 13.5 1.7 0.078 12.9 0.5 2.1 2 0 0 2 2 2 0 F-box domain Radical_SAM_C PF16199.5 EFA75665.1 - 4e-32 110.1 0.0 7.7e-32 109.2 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EFA75665.1 - 8.3e-18 65.3 0.0 3.3e-17 63.4 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EFA75665.1 - 2.1e-12 47.3 0.1 3.7e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA75665.1 - 1.6e-06 28.1 0.1 4.1e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA75665.1 - 0.00056 20.3 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA75665.1 - 0.024 14.6 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein DUF4231 PF14015.6 EFA75666.1 - 2.6 8.5 10.8 1 9.8 0.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) MCD PF05292.11 EFA75668.1 - 1.8e-42 145.7 0.4 3.4e-22 79.2 0.1 2.1 1 1 1 2 2 2 2 Malonyl-CoA decarboxylase C-terminal domain YonK PF09642.10 EFA75668.1 - 0.25 11.5 2.1 22 5.3 0.1 2.8 3 0 0 3 3 3 0 YonK protein DEAD PF00270.29 EFA75669.1 - 2.4e-49 167.5 0.0 4.3e-49 166.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA75669.1 - 1.2e-30 106.1 0.0 4.1e-30 104.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA75669.1 - 0.0005 20.1 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit VWC PF00093.18 EFA75672.1 - 8.2 6.8 37.7 4.8 7.6 7.9 3.0 2 1 1 3 3 3 0 von Willebrand factor type C domain Pro_isomerase PF00160.21 EFA75673.1 - 6.7e-47 159.7 0.1 8e-47 159.4 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_C98 PF15499.6 EFA75673.1 - 0.044 13.2 0.0 0.059 12.8 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase MWFE PF15879.5 EFA75674.1 - 3e-11 43.3 0.0 3.9e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Acetyltransf_1 PF00583.25 EFA75675.1 - 1.3e-08 35.1 0.0 1.8e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA75675.1 - 2e-07 31.3 0.0 3.7e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA75675.1 - 3.7e-07 30.1 0.0 5.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FNIP PF05725.12 EFA75676.1 - 8.7e-06 25.8 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 FNIP Repeat MFS_1 PF07690.16 EFA75677.1 - 1.3e-25 90.1 52.0 1.3e-24 86.8 28.6 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Metallophos PF00149.28 EFA75677.1 - 2.9e-13 50.8 0.7 2.9e-13 50.8 0.7 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase ETRAMP PF09716.10 EFA75677.1 - 0.15 12.1 8.8 3.3 7.8 0.1 2.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) MFS_3 PF05977.13 EFA75677.1 - 0.38 9.1 15.4 1 7.6 15.4 1.6 1 1 0 1 1 1 0 Transmembrane secretion effector Peptidase_C5 PF00770.18 EFA75677.1 - 0.39 10.3 5.3 0.8 9.3 0.3 3.1 3 0 0 3 3 3 0 Adenovirus endoprotease Sugar_tr PF00083.24 EFA75677.1 - 3.6 6.3 29.5 0.0082 15.1 3.3 2.7 3 0 0 3 3 3 0 Sugar (and other) transporter DUF1168 PF06658.12 EFA75678.1 - 1.2e-28 99.7 23.1 1.4e-28 99.4 23.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) MRP-S26 PF14943.6 EFA75678.1 - 0.36 10.7 19.7 0.5 10.3 19.7 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Ribosomal_S8e PF01201.22 EFA75678.1 - 0.47 10.6 0.0 0.47 10.6 0.0 2.2 1 1 1 2 2 2 0 Ribosomal protein S8e RR_TM4-6 PF06459.12 EFA75678.1 - 4.9 6.9 17.2 5.4 6.8 17.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.25 EFA75679.1 - 1.9e-69 234.0 0.0 2.4e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75679.1 - 4.9e-26 91.6 0.0 6.6e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA75679.1 - 2e-08 33.9 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SeqA PF03925.13 EFA75679.1 - 0.0024 17.8 0.1 0.0066 16.4 0.1 1.7 1 0 0 1 1 1 1 SeqA protein C-terminal domain Serpentine_r_xa PF03383.15 EFA75679.1 - 0.0089 16.0 0.3 0.015 15.3 0.3 1.3 1 0 0 1 1 1 1 Caenorhabditis serpentine receptor-like protein, class xa Kdo PF06293.14 EFA75679.1 - 0.039 13.3 0.0 0.072 12.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ion_trans PF00520.31 EFA75681.1 - 5.9e-09 35.5 5.5 5.9e-09 35.5 5.5 1.6 2 0 0 2 2 2 1 Ion transport protein Comm PF15957.5 EFA75681.1 - 0.1 13.0 1.1 11 6.4 0.0 2.9 2 1 0 2 2 2 0 Commissureless CN_hydrolase PF00795.22 EFA75682.1 - 3.8e-67 226.4 0.0 4.4e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF4834 PF16118.5 EFA75683.1 - 0.011 16.7 11.3 0.015 16.3 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 EFA75683.1 - 0.019 14.1 7.6 0.021 13.9 7.6 1.0 1 0 0 1 1 1 0 CLN3 protein DUF1980 PF09323.10 EFA75683.1 - 0.025 14.5 5.6 0.029 14.3 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) EIIBC-GUT_N PF03612.14 EFA75683.1 - 0.035 13.9 7.4 0.037 13.8 7.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 EFA75683.1 - 0.036 12.9 11.5 0.039 12.7 11.5 1.0 1 0 0 1 1 1 0 Presenilin GAGA_bind PF06217.12 EFA75683.1 - 0.059 13.6 11.3 0.065 13.5 11.3 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family SpoIIP PF07454.11 EFA75683.1 - 0.082 12.4 12.3 0.092 12.2 12.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 EFA75683.1 - 0.098 12.4 7.3 0.11 12.2 7.3 1.2 1 0 0 1 1 1 0 Connexin HCO3_cotransp PF00955.21 EFA75683.1 - 0.1 11.4 5.3 0.12 11.2 5.3 1.0 1 0 0 1 1 1 0 HCO3- transporter family V_ATPase_I PF01496.19 EFA75683.1 - 0.13 10.1 11.4 0.15 10.0 11.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CPSF100_C PF13299.6 EFA75683.1 - 0.14 12.4 7.9 0.15 12.2 7.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4446 PF14584.6 EFA75683.1 - 0.15 12.1 5.6 0.17 11.8 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) FHIPEP PF00771.20 EFA75683.1 - 0.18 10.2 4.9 0.19 10.1 4.9 1.0 1 0 0 1 1 1 0 FHIPEP family Spt20 PF12090.8 EFA75683.1 - 0.18 11.4 39.3 0.21 11.2 39.3 1.1 1 0 0 1 1 1 0 Spt20 family Nucleoside_tran PF01733.18 EFA75683.1 - 0.21 11.0 4.1 0.24 10.8 4.1 1.1 1 0 0 1 1 1 0 Nucleoside transporter SID-1_RNA_chan PF13965.6 EFA75683.1 - 0.21 10.0 5.5 0.23 9.8 5.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 UPF0524 PF15823.5 EFA75683.1 - 0.25 10.7 7.2 0.28 10.5 7.2 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 Folate_carrier PF01770.18 EFA75683.1 - 0.28 9.9 3.9 0.28 9.8 3.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier EOS1 PF12326.8 EFA75683.1 - 0.32 10.9 4.0 0.37 10.7 4.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein CSG2 PF16965.5 EFA75683.1 - 0.45 9.4 6.1 0.49 9.3 6.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator WASH-7_C PF14746.6 EFA75683.1 - 0.65 9.7 13.0 0.79 9.4 13.0 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Band_3_cyto PF07565.13 EFA75683.1 - 0.72 9.6 13.6 0.86 9.4 13.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2370 PF10176.9 EFA75683.1 - 0.74 9.4 8.2 0.88 9.2 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) GNAT_acetyltr_2 PF13718.6 EFA75683.1 - 0.75 9.2 9.6 0.87 8.9 9.6 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Folliculin PF11704.8 EFA75683.1 - 0.94 9.3 10.9 1.1 9.2 10.9 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport NEMP PF10225.9 EFA75683.1 - 0.97 9.0 4.3 1.1 8.8 4.3 1.1 1 0 0 1 1 1 0 NEMP family FKS1_dom1 PF14288.6 EFA75683.1 - 1.4 9.2 9.3 2.6 8.4 9.3 1.5 1 1 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 MTP18 PF10558.9 EFA75683.1 - 1.6 8.7 5.0 1.9 8.4 5.0 1.3 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Ureide_permease PF07168.11 EFA75683.1 - 1.6 7.4 5.1 1.8 7.3 5.1 1.0 1 0 0 1 1 1 0 Ureide permease HemX PF04375.14 EFA75683.1 - 1.7 7.9 28.7 1.9 7.7 28.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Neur_chan_memb PF02932.16 EFA75683.1 - 1.7 8.6 8.5 1.8 8.5 8.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 EFA75683.1 - 1.8 7.4 5.7 1.9 7.3 5.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) O-antigen_lig PF13425.6 EFA75683.1 - 3.2 6.5 10.0 3.4 6.4 10.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF853 PF05872.12 EFA75683.1 - 3.5 6.1 11.6 4.1 5.9 11.6 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) UPF0560 PF10577.9 EFA75683.1 - 3.7 5.9 17.9 3.7 5.9 17.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ctr PF04145.15 EFA75683.1 - 3.8 8.1 7.3 4.4 7.9 7.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Kei1 PF08552.11 EFA75683.1 - 4.8 7.0 5.3 5.4 6.9 5.3 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Membralin PF09746.9 EFA75683.1 - 5 6.1 10.1 5.1 6.0 10.1 1.0 1 0 0 1 1 1 0 Tumour-associated protein OATP PF03137.20 EFA75683.1 - 5.1 5.3 5.2 5.2 5.2 5.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2722 PF10846.8 EFA75683.1 - 5.9 5.7 28.9 7.7 5.3 28.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FAM60A PF15396.6 EFA75683.1 - 7.2 6.5 11.4 8.3 6.3 11.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 EFA75683.1 - 7.5 4.7 26.5 7.7 4.7 26.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CemA PF03040.14 EFA75683.1 - 8 6.3 9.6 9.7 6.0 9.6 1.0 1 0 0 1 1 1 0 CemA family TERB2 PF15101.6 EFA75683.1 - 9.5 6.2 18.5 14 5.7 18.5 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Exo_endo_phos PF03372.23 EFA75685.1 - 3.5e-09 36.5 0.0 5.2e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HBB PF06777.11 EFA75685.1 - 0.072 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Helical and beta-bridge domain NCA2 PF08637.10 EFA75686.1 - 3.1e-39 134.9 6.0 2.1e-38 132.1 3.7 3.1 2 1 1 3 3 3 1 ATP synthase regulation protein NCA2 Abhydrolase_1 PF00561.20 EFA75687.1 - 1.4e-06 28.1 0.3 1e-05 25.4 0.3 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA75687.1 - 1.7e-06 28.8 0.0 1.9e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA75687.1 - 0.0011 18.3 0.2 0.0057 15.9 0.2 1.8 1 1 1 2 2 2 1 Serine aminopeptidase, S33 DUF818 PF05677.12 EFA75687.1 - 0.0043 16.1 0.0 0.0068 15.4 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_3 PF07859.13 EFA75687.1 - 0.0078 16.1 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 EFA75687.1 - 0.01 15.4 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EFA75687.1 - 0.016 14.7 0.0 0.048 13.1 0.0 1.7 1 1 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 EFA75687.1 - 0.047 13.5 0.1 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF92 PF01940.16 EFA75688.1 - 4.9e-77 258.5 2.0 6.2e-77 258.2 2.0 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 NQR2_RnfD_RnfE PF03116.15 EFA75688.1 - 0.02 14.3 0.5 0.02 14.3 0.5 1.7 2 0 0 2 2 2 0 NQR2, RnfD, RnfE family RhoGEF PF00621.20 EFA75689.1 - 7e-40 137.2 8.0 7e-40 137.2 8.0 2.1 2 0 0 2 2 2 1 RhoGEF domain CH PF00307.31 EFA75689.1 - 1.8e-31 108.5 0.4 6.2e-15 55.3 0.8 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA75689.1 - 3.1e-06 26.9 1.0 0.13 12.1 0.1 3.6 3 0 0 3 3 3 2 CAMSAP CH domain IQ_SEC7_PH PF16453.5 EFA75689.1 - 7.5e-06 26.0 3.5 6.9e-05 22.8 0.5 3.0 3 0 0 3 3 3 1 PH domain PH PF00169.29 EFA75689.1 - 0.0002 21.8 0.6 0.00068 20.1 0.6 1.9 1 0 0 1 1 1 1 PH domain IQ PF00612.27 EFA75689.1 - 0.0021 17.7 1.0 0.0059 16.3 1.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif PH_13 PF16652.5 EFA75689.1 - 0.0024 17.7 2.3 0.0024 17.7 2.3 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain CH_2 PF06294.11 EFA75689.1 - 0.0033 17.5 0.5 5.4 7.2 0.0 3.5 3 0 0 3 3 3 2 CH-like domain in sperm protein PH_16 PF17838.1 EFA75689.1 - 0.021 14.7 0.9 0.12 12.3 0.1 2.5 2 0 0 2 2 2 0 PH domain PH_2 PF08458.10 EFA75689.1 - 0.068 13.5 2.1 0.078 13.3 0.6 1.9 2 0 0 2 2 2 0 Plant pleckstrin homology-like region ZapA PF05164.13 EFA75689.1 - 0.088 13.3 0.7 1 9.8 0.2 2.6 2 0 0 2 2 2 0 Cell division protein ZapA DUF4988 PF16378.5 EFA75689.1 - 0.26 10.9 4.7 1.3 8.7 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF1664 PF07889.12 EFA75689.1 - 0.4 10.7 6.3 0.38 10.8 0.9 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 EFA75689.1 - 2.7 8.4 12.4 2.3 8.6 0.9 4.9 5 0 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ALMT PF11744.8 EFA75689.1 - 3.8 6.2 11.3 8.7 5.0 11.3 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter Baculo_PEP_C PF04513.12 EFA75689.1 - 9.1 6.3 20.8 0.1 12.6 9.5 3.0 3 0 0 3 3 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LRR_6 PF13516.6 EFA75690.1 - 1.9e-32 108.5 57.8 1.7e-06 27.6 0.6 16.0 16 0 0 16 16 16 10 Leucine Rich repeat LRR_4 PF12799.7 EFA75690.1 - 1.7e-09 37.8 53.9 0.0063 16.9 0.3 10.2 8 2 5 13 13 13 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA75690.1 - 1.7e-07 30.8 23.5 20 6.2 0.1 12.3 11 1 0 11 11 11 1 Leucine Rich Repeat F-box-like PF12937.7 EFA75690.1 - 0.073 13.0 0.7 0.16 11.9 0.7 1.6 1 0 0 1 1 1 0 F-box-like cwf18 PF08315.12 EFA75691.1 - 7.9e-17 62.2 33.9 2.9e-13 50.6 33.9 2.7 1 1 0 1 1 1 1 cwf18 pre-mRNA splicing factor Ribosomal_60s PF00428.19 EFA75691.1 - 0.024 15.2 3.3 0.089 13.4 3.3 2.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein AAA_15 PF13175.6 EFA75691.1 - 3.4 7.3 46.2 0.65 9.6 19.5 2.0 1 1 0 2 2 2 0 AAA ATPase domain TMV_coat PF00721.21 EFA75691.1 - 4.6 7.0 13.4 0.78 9.6 5.5 2.4 2 0 0 2 2 2 0 Virus coat protein (TMV like) HECT PF00632.25 EFA75693.1 - 1.2e-83 281.1 0.1 2.1e-83 280.4 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Kelch_4 PF13418.6 EFA75693.1 - 1e-30 105.5 14.2 4.2e-08 33.1 2.3 5.8 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA75693.1 - 1.5e-23 82.3 14.8 1.3e-06 28.5 1.1 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFA75693.1 - 2e-23 81.7 3.4 1.6e-06 27.6 0.0 5.8 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFA75693.1 - 2e-18 66.2 15.0 8.3e-07 29.2 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA75693.1 - 2.8e-15 55.9 17.0 0.0047 16.9 0.0 7.5 7 1 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 EFA75693.1 - 6.9e-12 44.8 12.9 0.00095 19.1 0.0 5.6 6 0 0 6 6 6 3 Kelch motif EGF_2 PF07974.13 EFA75693.1 - 1.1 9.7 14.0 2.6 8.5 14.0 1.6 1 0 0 1 1 1 0 EGF-like domain PRC2_HTH_1 PF18118.1 EFA75693.1 - 2.8 8.8 4.5 6.9 7.5 2.6 2.4 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain B_lectin PF01453.24 EFA75695.1 - 4.9e-16 59.2 3.8 5.5e-05 23.7 0.1 4.2 2 2 2 4 4 4 4 D-mannose binding lectin PHZA_PHZB PF03284.13 EFA75695.1 - 0.056 13.1 0.0 0.33 10.6 0.0 1.9 2 0 0 2 2 2 0 Phenazine biosynthesis protein A/B NHL PF01436.21 EFA75695.1 - 0.096 12.8 0.9 19 5.5 0.0 3.8 4 0 0 4 4 4 0 NHL repeat BTB PF00651.31 EFA75696.1 - 1e-21 77.2 1.4 5.7e-21 74.8 0.4 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EFA75696.1 - 0.0058 16.7 2.2 0.018 15.2 0.1 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF5028 PF16431.5 EFA75696.1 - 0.1 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5028) Macoilin PF09726.9 EFA75696.1 - 0.2 10.2 4.9 0.21 10.1 4.9 1.1 1 0 0 1 1 1 0 Macoilin family EamA PF00892.20 EFA75697.1 - 7.2e-30 103.9 26.6 9.1e-19 68.0 14.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EFA75697.1 - 0.00036 19.6 4.7 0.057 12.4 0.1 2.3 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Mg_trans_NIPA PF05653.14 EFA75697.1 - 0.00063 18.9 4.8 0.0024 17.0 0.9 2.4 2 0 0 2 2 2 1 Magnesium transporter NIPA TPT PF03151.16 EFA75697.1 - 0.0011 18.4 13.9 0.0015 17.9 13.9 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 EFA75697.1 - 0.0014 17.9 1.9 0.0014 17.9 1.9 2.0 2 1 0 2 2 2 1 Nucleotide-sugar transporter SLC35F PF06027.12 EFA75697.1 - 0.0078 15.8 15.2 0.029 13.9 9.1 2.5 2 1 1 3 3 3 3 Solute carrier family 35 UPF0060 PF02694.15 EFA75697.1 - 0.37 11.0 5.6 0.38 11.0 2.8 2.1 2 0 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family 7TMR-DISM_7TM PF07695.11 EFA75697.1 - 1.4 8.7 18.6 1.1 9.1 10.1 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling SnoaL_2 PF12680.7 EFA75698.1 - 0.044 14.4 0.0 0.11 13.1 0.0 1.7 1 1 0 1 1 1 0 SnoaL-like domain BK_channel_a PF03493.18 EFA75699.1 - 9.5e-22 77.0 0.0 3.5e-21 75.2 0.0 2.0 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 EFA75699.1 - 3.4e-13 49.4 2.1 7.5e-12 45.1 0.1 2.8 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 EFA75699.1 - 7.6e-11 41.7 13.2 2e-08 33.7 7.9 3.0 2 1 1 3 3 3 2 Ion transport protein SecY PF00344.20 EFA75699.1 - 0.0004 19.7 0.9 0.00075 18.8 0.9 1.3 1 0 0 1 1 1 1 SecY translocase Glycophorin_A PF01102.18 EFA75699.1 - 0.022 15.0 0.0 0.072 13.3 0.0 1.9 1 0 0 1 1 1 0 Glycophorin A TUG-UBL1 PF11470.8 EFA75700.1 - 9.3e-20 70.6 0.6 1.1e-18 67.2 0.2 3.0 3 0 0 3 3 3 1 TUG ubiquitin-like domain UBX PF00789.20 EFA75700.1 - 2e-08 34.3 0.3 0.0028 17.8 0.1 2.8 2 0 0 2 2 2 2 UBX domain DUF4520 PF15016.6 EFA75700.1 - 0.044 13.9 0.2 0.18 11.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4520) CDC27 PF09507.10 EFA75700.1 - 5.8 6.2 36.3 0.44 9.9 17.1 2.3 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Kelch_6 PF13964.6 EFA75701.1 - 6.6e-18 64.3 1.5 1.6e-05 25.0 0.0 4.9 4 1 1 5 5 5 3 Kelch motif BTB_2 PF02214.22 EFA75701.1 - 1.3e-16 60.7 0.0 2.9e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.25 EFA75701.1 - 3.1e-14 52.3 18.4 8.3e-08 31.7 0.0 6.6 8 0 0 8 8 8 2 Kelch motif Kelch_4 PF13418.6 EFA75701.1 - 5.4e-09 35.9 0.3 0.015 15.3 0.0 4.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA75701.1 - 1.7e-07 30.9 1.0 0.031 14.3 0.0 4.8 3 1 1 4 4 4 2 Kelch motif BTB_3 PF16017.5 EFA75701.1 - 0.00035 20.6 0.0 0.00076 19.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.6 EFA75701.1 - 0.0045 16.9 5.8 0.015 15.3 0.0 4.1 4 0 0 4 4 4 1 Kelch motif CBM65_1 PF18259.1 EFA75701.1 - 0.012 15.7 0.8 0.81 9.9 0.0 2.5 1 1 1 2 2 2 0 Carbohydrate binding module 65 domain 1 Rsm22 PF09243.10 EFA75703.1 - 8.9e-69 231.8 0.0 2.2e-68 230.5 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 EFA75703.1 - 9.1e-08 32.1 0.0 3.2e-07 30.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA75703.1 - 0.00033 21.2 0.0 0.0015 19.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA75703.1 - 0.00037 21.1 0.0 0.0028 18.3 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA75703.1 - 0.00047 20.9 0.0 0.0044 17.7 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain GTP_CH_N PF12471.8 EFA75703.1 - 0.0096 15.7 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 1 GTP cyclohydrolase N terminal Methyltransf_31 PF13847.6 EFA75703.1 - 0.011 15.6 0.0 0.07 12.9 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain EGF_2 PF07974.13 EFA75704.1 - 0.059 13.8 15.6 0.13 12.6 15.6 1.6 1 0 0 1 1 1 0 EGF-like domain Pkinase PF00069.25 EFA75705.1 - 4.8e-80 268.7 0.0 1.1e-79 267.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain efThoc1 PF11957.8 EFA75705.1 - 1.9e-52 178.6 40.5 5.9e-43 147.3 11.0 4.2 3 2 1 4 4 4 3 THO complex subunit 1 transcription elongation factor Pkinase_Tyr PF07714.17 EFA75705.1 - 1.8e-41 142.2 0.0 3.8e-41 141.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFA75705.1 - 0.00014 21.3 0.0 0.00031 20.2 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA75705.1 - 0.65 9.9 2.0 6 6.7 0.0 2.8 3 1 0 3 3 3 0 Phosphotransferase enzyme family COMM_domain PF07258.14 EFA75706.1 - 3e-20 72.1 2.2 3.9e-20 71.7 0.9 1.9 2 0 0 2 2 2 1 COMM domain FOXO_KIX_bdg PF16675.5 EFA75706.1 - 0.0012 19.1 0.8 0.0024 18.2 0.8 1.5 1 0 0 1 1 1 1 KIX-binding domain of forkhead box O, CR2 Beta-lactamase PF00144.24 EFA75707.1 - 2e-31 109.5 0.2 4.4e-31 108.3 0.2 1.4 1 1 0 1 1 1 1 Beta-lactamase Homeodomain PF00046.29 EFA75708.1 - 6.4e-15 54.7 5.4 2.2e-14 53.0 5.4 2.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EFA75708.1 - 2.8e-05 23.9 0.1 0.00011 22.0 0.1 2.0 1 0 0 1 1 1 1 Homeobox KN domain SUIM_assoc PF16619.5 EFA75708.1 - 0.36 10.9 0.0 0.36 10.9 0.0 5.2 3 2 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 ABC1 PF03109.16 EFA75709.1 - 6.5e-31 107.0 0.3 1.5e-30 105.8 0.0 1.7 2 0 0 2 2 2 1 ABC1 family Activator_LAG-3 PF11498.8 EFA75709.1 - 0.0094 15.0 8.7 0.014 14.3 8.7 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Malate_synthase PF01274.22 EFA75709.1 - 0.022 13.1 0.1 0.03 12.6 0.1 1.2 1 0 0 1 1 1 0 Malate synthase DUF1151 PF06625.11 EFA75709.1 - 1.2 9.1 10.7 5.4 7.0 6.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) DHR-2 PF06920.13 EFA75710.1 - 5.8e-65 219.9 3.0 5.8e-65 219.9 3.0 3.1 3 1 1 4 4 4 2 Dock homology region 2 DOCK_N PF16172.5 EFA75710.1 - 1.2e-46 159.4 12.4 3.8e-36 124.8 0.2 3.4 3 1 0 3 3 3 2 DOCK N-terminus DOCK-C2 PF14429.6 EFA75710.1 - 1.4e-31 109.8 0.2 1.1e-30 107.0 0.2 2.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EFA75710.1 - 4e-07 29.8 0.0 7.6e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA75710.1 - 0.00029 20.4 0.0 0.00063 19.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SUIM_assoc PF16619.5 EFA75710.1 - 1.8 8.7 19.2 0.48 10.5 3.3 3.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Matrilin_ccoil PF10393.9 EFA75712.1 - 0.066 13.1 0.2 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin RPAP2_Rtr1 PF04181.13 EFA75713.1 - 1.1e-21 76.9 2.0 3.1e-21 75.5 2.0 1.8 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF3430 PF11912.8 EFA75714.1 - 5.1e-22 79.0 25.0 5.7e-22 78.8 25.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) Tubulin-binding PF00418.19 EFA75714.1 - 0.17 11.9 0.4 0.44 10.6 0.4 1.7 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat Topoisom_bac PF01131.20 EFA75716.1 - 1.3e-107 360.4 0.0 2.1e-107 359.7 0.0 1.3 1 0 0 1 1 1 1 DNA topoisomerase Pribosyltran_N PF13793.6 EFA75716.1 - 7.8e-48 161.2 0.4 2.4e-46 156.5 0.0 3.0 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFA75716.1 - 4.5e-41 140.9 4.2 4.3e-38 131.2 1.5 3.0 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFA75716.1 - 3.4e-16 59.1 1.5 8.1e-16 57.9 1.5 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Toprim PF01751.22 EFA75716.1 - 1.5e-15 57.3 0.0 5.1e-15 55.6 0.0 2.0 1 0 0 1 1 1 1 Toprim domain UPRTase PF14681.6 EFA75716.1 - 0.027 13.9 0.2 0.052 13.0 0.2 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Toprim_4 PF13662.6 EFA75716.1 - 0.059 13.8 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 Toprim domain Zn_Tnp_IS1595 PF12760.7 EFA75716.1 - 0.79 9.7 13.6 1.8 8.6 4.0 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain Ank_2 PF12796.7 EFA75717.1 - 6.6e-21 74.7 7.3 7.3e-07 29.7 0.1 5.5 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75717.1 - 1.1e-17 64.2 9.0 0.011 16.4 0.0 8.7 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75717.1 - 2.1e-15 56.6 2.8 0.88 10.0 0.0 9.1 6 2 4 10 10 10 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75717.1 - 1.1e-10 40.8 1.4 1.4 9.7 0.0 8.9 9 1 1 10 10 10 1 Ankyrin repeat DUF5049 PF16468.5 EFA75717.1 - 0.0021 17.9 0.2 53 3.8 0.0 6.2 6 1 2 8 8 8 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA75717.1 - 0.007 16.8 2.7 44 4.8 0.1 5.8 5 2 1 6 6 6 0 Ankyrin repeat Coiled PF05710.12 EFA75718.1 - 2e-06 28.5 2.3 2.2e-06 28.4 2.3 1.2 1 0 0 1 1 1 1 Coiled coil GPHR_N PF12537.8 EFA75718.1 - 0.027 14.6 0.5 0.033 14.3 0.5 1.2 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal WD40 PF00400.32 EFA75719.1 - 2.5e-10 40.8 4.7 0.17 12.8 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75719.1 - 1.4e-08 34.9 0.0 1.5 9.1 0.0 5.0 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain TPR_17 PF13431.6 EFA75721.1 - 1.4e-21 75.2 15.2 0.081 13.3 0.1 11.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75721.1 - 4.7e-07 29.4 14.3 4.6 7.0 0.0 8.3 8 0 0 8 8 8 3 TPR repeat TPR_14 PF13428.6 EFA75721.1 - 0.00095 19.8 0.0 85 4.4 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75721.1 - 0.0018 18.3 4.7 22 5.5 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA75721.1 - 0.0021 18.1 0.7 2.2e+02 2.4 0.0 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat ABC_membrane_2 PF06472.15 EFA75721.1 - 0.0073 15.7 0.0 4.3 6.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 TPR_1 PF00515.28 EFA75721.1 - 0.023 14.5 7.8 14 5.7 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA75722.1 - 3.8e-08 33.2 0.7 0.0032 17.7 0.2 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75722.1 - 0.0007 19.2 0.9 10 5.9 0.1 3.7 4 0 0 4 4 4 3 TPR repeat Utp14 PF04615.13 EFA75726.1 - 1.2e-70 239.1 45.0 1.2e-70 239.1 45.0 1.7 2 0 0 2 2 2 1 Utp14 protein MPP6 PF10175.9 EFA75726.1 - 0.0041 17.6 16.2 0.0041 17.6 16.2 5.1 4 2 1 5 5 5 1 M-phase phosphoprotein 6 DUF3439 PF11921.8 EFA75727.1 - 0.53 10.3 5.9 0.84 9.6 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ndc1_Nup PF09531.10 EFA75727.1 - 6.1 5.4 5.0 7.6 5.1 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mucin PF01456.17 EFA75727.1 - 7.6 6.5 16.9 13 5.8 16.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 EFA75727.1 - 8.9 6.8 10.2 15 6.1 10.2 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SNF5 PF04855.12 EFA75728.1 - 4.8e-32 111.7 0.2 2.6e-16 60.1 0.0 4.0 1 1 1 3 3 3 2 SNF5 / SMARCB1 / INI1 Neur_chan_memb PF02932.16 EFA75730.1 - 0.041 13.9 12.8 1.3 9.0 0.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Activator_LAG-3 PF11498.8 EFA75730.1 - 0.12 11.3 62.0 0.25 10.3 62.0 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Exonuc_VII_L PF02601.15 EFA75730.1 - 0.5 9.9 19.3 0.069 12.7 14.6 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit Myc_N PF01056.18 EFA75730.1 - 0.72 9.7 20.2 0.31 10.9 7.6 2.2 2 0 0 2 2 2 0 Myc amino-terminal region DUF572 PF04502.13 EFA75730.1 - 2.9 7.4 18.1 1.7 8.2 5.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) ArsP_2 PF11449.8 EFA75730.1 - 5.9 6.0 6.4 11 5.1 6.4 1.3 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter Macoilin PF09726.9 EFA75730.1 - 7.6 5.0 29.9 4.2 5.8 8.6 2.3 2 0 0 2 2 2 0 Macoilin family Hid1 PF12722.7 EFA75730.1 - 8.3 4.4 25.3 0.48 8.5 2.5 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Vma12 PF11712.8 EFA75730.1 - 9.9 6.2 8.8 26 4.8 8.8 1.8 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF737 PF05300.11 EFA75731.1 - 0.016 15.5 0.1 0.016 15.5 0.1 4.2 3 2 0 3 3 3 0 Protein of unknown function (DUF737) DUF2782 PF11191.8 EFA75731.1 - 0.063 13.5 0.3 27 5.1 0.0 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2782) Zip PF02535.22 EFA75731.1 - 3.6 6.7 15.6 0.15 11.2 0.5 3.3 3 0 0 3 3 3 0 ZIP Zinc transporter bZIP_2 PF07716.15 EFA75733.1 - 2.7e-05 24.1 10.1 2.7e-05 24.1 10.1 3.6 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 EFA75733.1 - 0.00016 21.7 8.8 0.00016 21.7 8.8 2.8 3 0 0 3 3 3 1 bZIP transcription factor PikAIV_N PF18605.1 EFA75733.1 - 0.3 10.7 1.8 0.77 9.4 1.8 1.7 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain CCDC85 PF10226.9 EFA75733.1 - 1 9.0 11.1 0.6 9.8 1.3 3.6 3 0 0 3 3 3 0 CCDC85 family HD_assoc PF13286.6 EFA75733.1 - 1.7 9.3 6.5 3.6 8.2 0.3 3.2 3 0 0 3 3 3 0 Phosphohydrolase-associated domain Mucin PF01456.17 EFA75733.1 - 7.8 6.5 19.0 0.24 11.4 12.1 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein TPR_17 PF13431.6 EFA75734.1 - 7.6e-09 35.4 4.4 0.034 14.5 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75734.1 - 0.00038 20.1 1.9 3.2 7.5 0.0 4.0 4 0 0 4 4 4 3 TPR repeat DUF5301 PF17225.3 EFA75734.1 - 0.085 13.3 0.1 5.4 7.5 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5300) TPR_17 PF13431.6 EFA75736.1 - 2.9e-05 24.1 5.8 6.6 7.3 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75736.1 - 0.049 13.3 4.9 0.61 9.8 0.1 4.3 6 0 0 6 6 6 0 TPR repeat TPR_1 PF00515.28 EFA75736.1 - 0.7 9.8 2.4 87 3.2 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat bZIP_2 PF07716.15 EFA75737.1 - 4.7e-05 23.4 4.9 4.7e-05 23.4 4.9 4.9 5 1 0 5 5 5 1 Basic region leucine zipper bZIP_1 PF00170.21 EFA75737.1 - 0.00022 21.2 5.3 0.00022 21.2 5.3 3.1 3 0 0 3 3 3 1 bZIP transcription factor CH PF00307.31 EFA75739.1 - 6.4e-11 42.4 0.9 8.3e-11 42.0 0.9 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 EFA75739.1 - 0.046 13.8 0.1 0.063 13.4 0.1 1.2 1 0 0 1 1 1 0 CH-like domain in sperm protein PLA2G12 PF06951.11 EFA75739.1 - 0.13 12.2 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Group XII secretory phospholipase A2 precursor (PLA2G12) Motile_Sperm PF00635.26 EFA75740.1 - 7e-24 83.8 0.4 7e-24 83.8 0.4 2.1 2 1 0 2 2 2 1 MSP (Major sperm protein) domain FNIP PF05725.12 EFA75741.1 - 1.8e-27 95.2 29.3 4.9e-08 33.0 0.1 8.7 6 2 4 10 10 10 8 FNIP Repeat F-box_5 PF18511.1 EFA75741.1 - 1.1e-05 24.9 0.1 2.4e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75741.1 - 3.1e-05 23.8 0.2 9.8e-05 22.2 0.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75741.1 - 0.013 15.3 0.1 0.051 13.5 0.1 2.0 1 0 0 1 1 1 0 F-box domain ArsA_HSP20 PF17886.1 EFA75741.1 - 0.064 12.8 0.0 1.9 8.1 0.0 3.2 2 0 0 2 2 2 0 HSP20-like domain found in ArsA GMP_synt_C PF00958.22 EFA75741.1 - 3.8 7.6 4.1 16 5.6 0.4 3.4 5 0 0 5 5 5 0 GMP synthase C terminal domain Ank_2 PF12796.7 EFA75742.1 - 2.1e-20 73.1 3.0 4.1e-06 27.3 0.2 5.8 4 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA75742.1 - 4e-17 60.6 2.7 0.42 11.3 0.0 9.9 8 2 2 10 10 10 4 Ankyrin repeat Ank_4 PF13637.6 EFA75742.1 - 7.1e-17 61.5 4.5 0.016 15.8 0.0 7.6 8 2 0 8 8 8 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75742.1 - 5e-11 42.6 3.5 0.031 14.6 0.1 8.1 4 3 4 8 8 8 2 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA75742.1 - 0.00024 20.9 13.3 0.29 10.8 0.9 4.4 3 2 1 4 4 4 3 Multigene family 530 protein DUF3447 PF11929.8 EFA75742.1 - 0.00046 20.1 0.3 0.00046 20.1 0.3 6.7 6 2 2 8 8 8 2 Domain of unknown function (DUF3447) HOIP-UBA PF16678.5 EFA75742.1 - 0.0074 16.3 1.1 0.72 9.8 0.1 3.0 2 1 1 3 3 3 1 HOIP UBA domain pair CLU PF13236.6 EFA75743.1 - 1.6e-33 116.4 0.0 3.4e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA75743.1 - 0.0073 16.4 0.1 0.0073 16.4 0.1 2.7 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 TPR_7 PF13176.6 EFA75743.1 - 0.1 12.7 0.0 0.34 11.0 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Uma2 PF05685.12 EFA75744.1 - 4.6e-09 36.0 0.0 8.4e-09 35.2 0.0 1.5 1 1 0 1 1 1 1 Putative restriction endonuclease RVT_1 PF00078.27 EFA75745.1 - 1.3e-41 142.6 0.3 3.2e-41 141.3 0.3 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FNIP PF05725.12 EFA75746.1 - 1.7e-32 111.3 33.3 3.1e-11 43.3 0.2 8.9 6 3 5 11 11 11 8 FNIP Repeat DKNYY PF13644.6 EFA75746.1 - 0.00043 21.1 7.1 0.0011 19.7 7.1 1.6 1 0 0 1 1 1 1 DKNYY family F-box_5 PF18511.1 EFA75746.1 - 0.0031 17.0 0.1 0.0069 15.9 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75746.1 - 0.011 15.6 0.1 0.032 14.1 0.1 1.8 1 0 0 1 1 1 0 F-box-like SwrA PF17423.2 EFA75746.1 - 0.13 12.2 5.3 0.04 13.9 1.3 2.2 2 0 0 2 2 2 0 Swarming motility protein DUF5072 PF16807.5 EFA75746.1 - 0.14 12.2 0.4 0.3 11.2 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5072) FidL_like PF15941.5 EFA75746.1 - 1 9.9 6.7 0.43 11.0 2.6 2.4 2 1 0 3 3 3 0 FidL-like putative membrane protein TIG PF01833.24 EFA75747.1 - 1.3e-40 137.3 158.8 2.7e-07 30.6 6.8 17.5 13 2 4 18 18 18 12 IPT/TIG domain COX_ARM PF06481.14 EFA75747.1 - 0.13 12.2 0.0 0.37 10.7 0.0 1.7 1 0 0 1 1 1 0 COX Aromatic Rich Motif FNIP PF05725.12 EFA75748.1 - 2.5e-24 85.2 32.5 1.9e-07 31.1 0.6 7.6 7 1 0 7 7 7 6 FNIP Repeat FG-GAP_2 PF14312.6 EFA75749.1 - 0.1 12.9 1.3 0.73 10.1 0.2 2.6 2 0 0 2 2 2 0 FG-GAP repeat FNIP PF05725.12 EFA75751.1 - 8.6e-24 83.4 22.0 1.1e-05 25.5 1.2 7.2 4 2 3 7 7 7 7 FNIP Repeat Ydr279_N PF17745.1 EFA75751.1 - 0.00023 21.3 2.1 0.0019 18.4 0.1 2.8 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain F-box_5 PF18511.1 EFA75751.1 - 0.0096 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 F-box Adeno_100 PF02438.16 EFA75752.1 - 0.038 12.2 0.1 0.043 12.0 0.1 1.0 1 0 0 1 1 1 0 Late 100kD protein FNIP PF05725.12 EFA75753.1 - 1.4e-14 54.0 20.0 0.00016 21.8 2.0 5.8 4 2 2 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA75753.1 - 0.0087 15.6 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 F-box Ydr279_N PF17745.1 EFA75753.1 - 0.052 13.8 4.3 0.12 12.7 0.2 3.0 3 0 0 3 3 3 0 Ydr279p protein triple barrel domain Cauli_VI PF01693.16 EFA75754.1 - 0.053 13.8 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 Caulimovirus viroplasmin Vps53_N PF04100.12 EFA75755.1 - 0.00071 18.6 0.1 0.00095 18.2 0.1 1.1 1 0 0 1 1 1 1 Vps53-like, N-terminal F-box_5 PF18511.1 EFA75755.1 - 0.00075 19.0 0.1 0.0014 18.2 0.1 1.4 1 0 0 1 1 1 1 F-box Ydr279_N PF17745.1 EFA75755.1 - 0.0058 16.9 0.8 0.23 11.8 0.0 2.3 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain F-box-like PF12937.7 EFA75755.1 - 0.022 14.7 0.2 0.038 13.9 0.2 1.4 1 0 0 1 1 1 0 F-box-like FNIP PF05725.12 EFA75756.1 - 3.1e-13 49.7 24.7 0.00016 21.8 2.0 7.0 5 3 1 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA75756.1 - 0.0016 17.9 0.1 0.0038 16.7 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75756.1 - 0.015 15.2 0.2 0.04 13.8 0.2 1.8 1 0 0 1 1 1 0 F-box-like Ydr279_N PF17745.1 EFA75756.1 - 0.084 13.1 1.6 0.94 9.8 0.1 2.8 2 0 0 2 2 2 0 Ydr279p protein triple barrel domain SwrA PF17423.2 EFA75756.1 - 0.53 10.3 5.3 0.17 11.9 1.0 2.3 2 0 0 2 2 2 0 Swarming motility protein zf-CCCH PF00642.24 EFA75757.1 - 0.0011 18.9 10.5 0.031 14.2 4.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFA75757.1 - 0.013 15.9 4.3 0.013 15.9 4.3 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EFA75757.1 - 4.7 7.1 8.2 0.66 9.8 3.9 1.9 2 0 0 2 2 2 0 CCCH-type zinc finger WD40 PF00400.32 EFA75758.1 - 1.1e-31 108.4 11.5 5.9e-09 36.4 0.3 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75758.1 - 5e-05 23.5 0.0 0.24 11.7 0.0 4.4 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain BUD22 PF09073.10 EFA75758.1 - 0.0036 16.7 32.7 0.006 16.0 32.7 1.2 1 0 0 1 1 1 1 BUD22 ORC6 PF05460.13 EFA75758.1 - 0.0036 16.6 4.8 0.0036 16.6 4.8 1.5 2 0 0 2 2 2 1 Origin recognition complex subunit 6 (ORC6) Ge1_WD40 PF16529.5 EFA75758.1 - 0.0038 16.2 0.4 13 4.6 0.0 3.9 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_S49_N PF08496.10 EFA75758.1 - 1.6 8.8 4.5 5.2 7.1 2.7 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal WD40_like PF17005.5 EFA75758.1 - 3 7.1 10.1 1.2 8.4 0.1 4.0 4 1 1 5 5 5 0 WD40-like domain PPP4R2 PF09184.11 EFA75758.1 - 6.7 6.2 28.0 19 4.8 28.0 1.7 1 0 0 1 1 1 0 PPP4R2 Inositol_P PF00459.25 EFA75759.1 - 1.7e-49 168.8 0.0 2.8e-49 168.1 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family STATa_Ig PF18214.1 EFA75761.1 - 1.9e-36 124.7 0.1 1.9e-36 124.7 0.1 3.7 4 1 0 4 4 4 1 STATa Immunoglobulin-like domain Dict-STAT-coil PF09267.10 EFA75761.1 - 7e-36 123.1 11.5 7e-36 123.1 11.5 3.6 3 1 0 3 3 3 1 Dictyostelium STAT, coiled coil DUF1556 PF07590.11 EFA75761.1 - 0.17 12.2 3.0 20 5.5 0.5 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1556) Aminopep PF10023.9 EFA75761.1 - 4.4 6.6 8.9 0.86 8.9 0.4 2.3 2 0 0 2 2 2 0 Putative aminopeptidase bZIP_1 PF00170.21 EFA75761.1 - 9.5 6.4 11.5 3 8.0 5.7 2.7 2 0 0 2 2 2 0 bZIP transcription factor SRF-TF PF00319.18 EFA75762.1 - 2.7e-24 84.4 0.3 4.5e-24 83.7 0.3 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) FNIP PF05725.12 EFA75763.1 - 3.8e-05 23.8 0.3 0.023 14.8 0.1 2.8 1 1 2 3 3 3 3 FNIP Repeat RCR PF12273.8 EFA75763.1 - 0.0015 19.2 1.0 0.0015 19.2 1.0 1.6 2 0 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red F-box_5 PF18511.1 EFA75763.1 - 0.0039 16.7 0.1 0.0097 15.5 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75763.1 - 0.026 14.4 0.6 0.05 13.5 0.3 1.7 2 0 0 2 2 2 0 F-box-like Tim17 PF02466.19 EFA75763.1 - 0.12 12.7 0.1 0.25 11.8 0.1 1.4 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family DUF2207 PF09972.9 EFA75763.1 - 1.2 7.8 5.9 0.24 10.1 2.5 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) FNIP PF05725.12 EFA75764.1 - 1.2e-26 92.6 15.4 8.3e-13 48.3 0.2 10.3 9 3 3 12 12 12 6 FNIP Repeat F-box_5 PF18511.1 EFA75764.1 - 1.6e-05 24.4 0.5 3.3e-05 23.4 0.5 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75764.1 - 0.00018 21.3 0.4 0.00048 20.0 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75764.1 - 0.0063 16.4 0.1 0.018 14.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain FNIP PF05725.12 EFA75765.1 - 1.6e-34 117.8 61.1 7e-10 38.9 0.3 14.4 11 4 4 15 15 15 12 FNIP Repeat F-box_5 PF18511.1 EFA75765.1 - 1.3e-09 37.5 1.4 0.00058 19.4 0.2 2.6 2 0 0 2 2 2 2 F-box F-box-like PF12937.7 EFA75765.1 - 0.0005 19.9 0.8 0.11 12.4 0.2 2.8 2 0 0 2 2 2 2 F-box-like Ydr279_N PF17745.1 EFA75765.1 - 0.0047 17.2 4.3 3.1 8.1 0.1 3.6 3 0 0 3 3 3 2 Ydr279p protein triple barrel domain DUF902 PF06001.13 EFA75765.1 - 0.64 10.5 4.3 23 5.6 0.0 3.4 4 0 0 4 4 4 0 Domain of Unknown Function (DUF902) TPR_17 PF13431.6 EFA75766.1 - 3.6e-41 136.6 16.4 2.8e-06 27.3 0.1 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 EFA75766.1 - 1.1e-23 82.6 25.1 0.00013 21.6 0.0 8.7 9 0 0 9 9 9 8 TPR repeat TPR_14 PF13428.6 EFA75766.1 - 0.00035 21.1 0.0 94 4.2 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA75766.1 - 0.00095 19.2 7.0 14 6.2 0.0 7.4 8 2 1 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA75766.1 - 0.0038 17.2 11.6 14 6.1 0.0 7.7 10 0 0 10 10 10 1 Tetratricopeptide repeat DUF1153 PF06627.11 EFA75766.1 - 0.0061 16.7 0.1 40 4.4 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF1153) TPR_1 PF00515.28 EFA75766.1 - 0.31 10.9 20.9 7.9 6.5 0.0 8.4 11 0 0 11 11 11 0 Tetratricopeptide repeat MGAT2 PF05060.14 EFA75769.1 - 2.4e-64 217.6 8.2 1.1e-63 215.5 8.2 1.8 1 1 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) Ac76 PF05814.11 EFA75769.1 - 0.0076 16.2 0.7 0.015 15.3 0.7 1.5 1 0 0 1 1 1 1 Orf76 (Ac76) PT PF04886.12 EFA75769.1 - 1 9.0 13.1 1.7 8.3 13.1 1.2 1 0 0 1 1 1 0 PT repeat Pkinase PF00069.25 EFA75770.1 - 5.6e-52 176.7 0.6 1e-51 175.9 0.6 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75770.1 - 7.2e-35 120.5 0.1 1e-34 120.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA75770.1 - 2.5e-08 33.1 0.0 4.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFA75770.1 - 5.4e-07 29.2 0.0 1.3e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFA75770.1 - 2.2e-05 23.6 3.2 2.2e-05 23.6 3.2 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFA75770.1 - 0.00035 20.0 0.1 0.00068 19.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFA75770.1 - 0.062 12.9 0.1 8.2 6.0 0.0 2.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFA75770.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AMP-binding PF00501.28 EFA75771.1 - 3e-69 233.7 0.0 2.1e-36 125.4 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFA75771.1 - 8.9e-17 61.8 0.0 2e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Methyltr_RsmB-F PF01189.17 EFA75772.1 - 3.3e-33 115.0 0.1 4.5e-18 65.6 0.1 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EFA75772.1 - 2e-06 27.7 0.3 7.2e-05 22.6 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA75772.1 - 7.5e-06 26.6 0.0 2.6e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA75772.1 - 1.4e-05 25.0 0.1 0.0005 19.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EFA75772.1 - 0.00014 22.1 0.4 0.00068 19.8 0.4 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EFA75772.1 - 0.00084 18.9 0.1 0.005 16.4 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EFA75772.1 - 0.0032 16.9 0.0 0.038 13.3 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Fibrillarin PF01269.17 EFA75772.1 - 0.041 13.0 0.0 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 Fibrillarin PCMT PF01135.19 EFA75772.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) BHD_2 PF10404.9 EFA75772.1 - 4.7 8.2 10.1 3.6 8.6 3.1 3.5 4 0 0 4 4 4 0 Rad4 beta-hairpin domain 2 DRY_EERY PF09750.9 EFA75772.1 - 9.7 6.5 11.5 0.24 11.7 3.5 2.3 3 0 0 3 3 3 0 Alternative splicing regulator GST_N_2 PF13409.6 EFA75773.1 - 1.7e-21 76.3 0.0 3.6e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA75773.1 - 5.5e-11 42.3 0.0 1.1e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA75773.1 - 0.00023 21.5 0.0 0.26 11.7 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA75773.1 - 0.001 19.2 0.1 0.0024 18.1 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA75773.1 - 0.0052 17.0 0.4 0.014 15.5 0.2 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain DUF5395 PF17373.2 EFA75773.1 - 0.0098 16.5 0.1 0.51 11.0 0.1 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5395) IF4E PF01652.18 EFA75774.1 - 1.7e-28 99.4 4.2 1.7e-28 99.4 4.2 2.0 2 0 0 2 2 2 1 Eukaryotic initiation factor 4E HAD_2 PF13419.6 EFA75775.1 - 0.039 14.0 0.5 0.083 13.0 0.5 1.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Beta_helix PF13229.6 EFA75776.1 - 0.0026 17.6 59.5 0.014 15.2 19.0 3.6 1 1 2 3 3 3 2 Right handed beta helix region Adeno_E3_CR2 PF02439.15 EFA75776.1 - 0.0092 15.7 0.5 0.02 14.7 0.5 1.6 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Syndecan PF01034.20 EFA75776.1 - 0.025 14.5 0.9 0.057 13.3 0.9 1.5 1 0 0 1 1 1 0 Syndecan domain SKA2 PF16740.5 EFA75777.1 - 0.36 10.6 8.8 0.21 11.4 4.1 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 XhlA PF10779.9 EFA75777.1 - 2 8.7 12.6 5 7.4 0.1 3.4 3 0 0 3 3 3 0 Haemolysin XhlA Tropomyosin PF00261.20 EFA75777.1 - 2 7.7 14.4 4.5 6.6 0.3 3.0 2 1 1 3 3 3 0 Tropomyosin DUF5339 PF17274.2 EFA75777.1 - 3.6 8.5 10.9 34 5.4 0.3 3.6 3 1 1 4 4 4 0 Family of unknown function (DUF5339) ZapB PF06005.12 EFA75777.1 - 4 8.0 14.6 0.55 10.7 0.7 2.7 2 1 0 2 2 2 0 Cell division protein ZapB DUF4404 PF14357.6 EFA75777.1 - 6.1 7.6 8.0 7.6 7.2 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF16 PF01519.16 EFA75777.1 - 8.3 7.0 18.4 0.91 10.0 2.7 3.3 2 1 0 3 3 3 0 Protein of unknown function DUF16 FNIP PF05725.12 EFA75778.1 - 7.5e-24 83.6 43.2 1.3e-08 34.9 3.0 9.2 5 2 4 9 9 9 7 FNIP Repeat Peptidase_C1 PF00112.23 EFA75779.1 - 3.6e-62 210.3 1.8 7e-62 209.4 1.8 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA75779.1 - 8.1e-14 51.8 2.4 8.1e-14 51.8 2.4 2.6 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) F-box_5 PF18511.1 EFA75779.1 - 0.0045 16.5 0.7 0.0089 15.6 0.7 1.4 1 0 0 1 1 1 1 F-box Peptidase_C1_2 PF03051.15 EFA75779.1 - 0.0061 15.4 0.1 0.0061 15.4 0.1 2.0 3 0 0 3 3 3 1 Peptidase C1-like family Peptidase_C39_2 PF13529.6 EFA75779.1 - 0.024 15.2 0.2 0.13 12.8 0.0 2.1 2 0 0 2 2 2 0 Peptidase_C39 like family F-box-like PF12937.7 EFA75779.1 - 0.096 12.6 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 F-box-like Ank_2 PF12796.7 EFA75780.1 - 1.6e-25 89.5 6.2 4.5e-07 30.4 0.1 6.2 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75780.1 - 2.1e-21 76.0 7.7 0.0002 21.9 0.0 8.6 6 4 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75780.1 - 8e-17 61.1 3.4 0.055 13.8 0.1 8.1 5 2 5 10 10 10 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75780.1 - 2.4e-10 39.7 3.5 1.8 9.4 0.0 9.3 12 0 0 12 12 12 2 Ankyrin repeat DUF5049 PF16468.5 EFA75780.1 - 7.2e-05 22.6 0.2 3.8 7.5 0.0 5.2 3 1 2 5 5 5 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA75780.1 - 0.00041 20.7 0.1 31 5.2 0.0 5.9 6 1 1 7 7 7 0 Ankyrin repeat FNIP PF05725.12 EFA75781.1 - 6.9e-21 74.1 51.5 2e-07 31.0 0.4 10.6 8 3 3 11 11 11 6 FNIP Repeat F-box-like PF12937.7 EFA75781.1 - 0.00046 20.0 0.3 0.0015 18.3 0.3 1.9 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA75781.1 - 0.0018 17.8 0.6 0.0037 16.8 0.6 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 EFA75781.1 - 0.0041 17.0 0.1 0.012 15.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EFA75781.1 - 2.7 8.2 6.9 11 6.4 0.2 5.1 5 0 0 5 5 5 0 Leucine Rich repeat FNIP PF05725.12 EFA75782.1 - 7.1e-20 70.9 22.7 3.6e-07 30.2 0.4 7.0 7 1 0 7 7 7 4 FNIP Repeat F-box_5 PF18511.1 EFA75782.1 - 0.006 16.1 0.2 0.012 15.1 0.2 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75782.1 - 0.021 14.7 0.2 0.11 12.4 0.1 2.3 2 0 0 2 2 2 0 F-box-like LRR_6 PF13516.6 EFA75783.1 - 1.1 9.5 0.1 1.1 9.5 0.1 3.1 4 0 0 4 4 4 0 Leucine Rich repeat Ank_2 PF12796.7 EFA75784.1 - 2e-19 69.9 6.7 0.00022 21.8 0.3 6.7 1 1 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75784.1 - 1.9e-14 53.5 0.5 0.0038 17.5 0.2 7.6 5 2 3 9 9 9 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75784.1 - 1.2e-11 44.9 8.1 0.00092 19.7 0.1 9.0 7 3 2 9 9 9 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75784.1 - 3.9e-10 39.1 3.2 0.11 13.1 0.0 8.6 11 0 0 11 11 11 1 Ankyrin repeat DUF1348 PF07080.11 EFA75784.1 - 0.00011 22.1 1.5 0.55 10.2 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1348) DUF5049 PF16468.5 EFA75784.1 - 0.022 14.7 0.0 5.7 6.9 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA75784.1 - 0.028 14.9 1.9 53 4.5 0.0 5.8 7 0 0 7 7 7 0 Ankyrin repeat FNIP PF05725.12 EFA75785.1 - 2.4e-21 75.6 15.5 3.5e-10 39.9 0.3 9.6 6 4 4 10 10 10 7 FNIP Repeat F-box_5 PF18511.1 EFA75785.1 - 0.03 13.9 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 F-box TIG PF01833.24 EFA75786.1 - 1.3e-62 207.8 87.4 1.4e-12 47.5 0.5 11.7 11 0 0 11 11 11 9 IPT/TIG domain DNase_II PF03265.15 EFA75786.1 - 1.1e-28 100.5 0.6 3.8e-17 62.6 1.4 2.4 2 0 0 2 2 2 2 Deoxyribonuclease II DUF5011 PF16403.5 EFA75786.1 - 0.077 13.1 0.6 1 9.5 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) Fungus-induced PF10917.8 EFA75787.1 - 0.15 12.4 0.7 0.15 12.4 0.7 1.5 2 0 0 2 2 2 0 Fungus-induced protein LPAM_1 PF08139.12 EFA75787.1 - 0.25 11.9 1.6 0.39 11.3 1.6 1.3 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Ank_4 PF13637.6 EFA75788.1 - 1.6e-19 70.0 2.8 0.00024 21.6 0.1 8.7 7 2 2 9 9 9 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75788.1 - 1.9e-18 66.8 5.6 9.5e-07 29.3 0.2 5.2 2 1 5 7 7 7 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75788.1 - 2e-11 43.9 1.5 1 9.8 0.1 7.2 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75788.1 - 3.2e-10 39.3 2.3 2.8 8.8 0.0 8.5 9 0 0 9 9 9 3 Ankyrin repeat Ank PF00023.30 EFA75788.1 - 0.016 15.6 0.2 67 4.2 0.0 5.7 4 3 0 4 4 4 0 Ankyrin repeat SRP1_TIP1 PF00660.17 EFA75788.1 - 0.098 12.7 0.1 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Seripauperin and TIP1 family Chromadorea_ALT PF05535.12 EFA75788.1 - 0.19 11.9 0.7 1.5 9.1 0.1 2.6 3 0 0 3 3 3 0 Chromadorea ALT protein RVT_1 PF00078.27 EFA75789.1 - 1e-26 93.8 0.4 3.8e-26 92.0 0.1 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EFA75789.1 - 5.7e-24 84.1 0.0 1.5e-23 82.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA75789.1 - 1.4e-21 76.7 0.0 4.4e-21 75.1 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EFA75789.1 - 7.3e-12 45.5 0.0 1.7e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EFA75789.1 - 5.4e-11 42.4 1.7 7.5e-11 42.0 0.1 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 EFA75789.1 - 1.6e-07 31.8 0.1 4.3e-07 30.4 0.1 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EFA75789.1 - 1.3e-06 28.9 0.0 3e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 EFA75789.1 - 2.8e-05 24.0 0.6 6.1e-05 22.9 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.20 EFA75789.1 - 0.00054 20.2 0.1 0.0014 18.9 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 EFA75789.1 - 0.23 11.2 0.5 0.58 9.9 0.5 1.7 1 0 0 1 1 1 0 Zinc knuckle AAA_23 PF13476.6 EFA75790.1 - 0.00043 20.8 9.0 0.0015 19.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFA75790.1 - 0.0055 17.2 0.0 0.014 15.9 0.0 1.7 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 EFA75790.1 - 0.053 13.6 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA75790.1 - 0.063 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EFA75790.1 - 0.064 13.8 0.1 0.27 11.8 0.0 2.2 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EFA75790.1 - 0.21 10.5 0.0 0.36 9.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EFA75791.1 - 0.00049 20.7 0.6 0.001 19.6 0.1 1.7 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFA75791.1 - 0.0019 18.7 0.0 0.0037 17.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EFA75791.1 - 0.0074 16.8 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFA75791.1 - 0.0084 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFA75791.1 - 0.02 15.0 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase 6PF2K PF01591.18 EFA75791.1 - 0.021 14.1 0.0 0.036 13.4 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_17 PF13207.6 EFA75791.1 - 0.061 13.7 0.1 0.19 12.2 0.0 1.9 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EFA75791.1 - 0.076 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 EFA75791.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 EFA75791.1 - 0.21 11.5 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 TackOD1 PF18551.1 EFA75792.1 - 0.0068 16.1 6.5 0.0085 15.8 6.5 1.2 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Gin PF10764.9 EFA75792.1 - 0.18 11.8 8.4 0.76 9.8 0.1 3.1 2 1 1 3 3 3 0 Inhibitor of sigma-G Gin zf-MYND PF01753.18 EFA75792.1 - 1.2 9.3 13.7 0.61 10.2 6.3 2.5 1 1 1 2 2 2 0 MYND finger Zn_Tnp_IS1595 PF12760.7 EFA75792.1 - 1.8 8.6 9.5 2.1 8.4 2.4 2.4 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_6 PF14599.6 EFA75792.1 - 3.7 7.6 9.3 0.27 11.3 2.0 2.3 2 1 0 2 2 2 0 Zinc-ribbon TackOD1 PF18551.1 EFA75793.1 - 0.0079 15.9 7.4 0.021 14.5 7.4 1.6 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 MukF_M PF17192.4 EFA75793.1 - 0.041 13.6 0.3 0.062 13.0 0.3 1.3 1 0 0 1 1 1 0 MukF middle domain Caudo_TAP PF02413.17 EFA75793.1 - 0.055 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Ofd1_CTDD PF10637.9 EFA75793.1 - 0.62 9.4 5.1 0.74 9.1 5.1 1.4 1 1 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term zf-trcl PF13451.6 EFA75793.1 - 1.2 9.1 11.0 0.28 11.1 5.2 2.7 2 1 0 2 2 2 0 Probable zinc-ribbon domain zinc-ribbons_6 PF07191.12 EFA75793.1 - 1.7 8.7 8.9 1.3 9.1 6.3 2.0 2 0 0 2 2 2 0 zinc-ribbons Ank_2 PF12796.7 EFA75794.1 - 5.5e-15 55.7 12.0 0.0002 21.9 0.8 6.2 2 2 5 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75794.1 - 6.7e-15 55.3 8.2 0.0054 17.3 0.0 7.2 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75794.1 - 2e-12 47.1 5.8 0.0056 17.0 0.0 7.3 3 2 4 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75794.1 - 3.9e-07 29.8 3.6 5.7 7.9 0.1 9.0 9 2 2 11 11 11 1 Ankyrin repeat DUF5049 PF16468.5 EFA75794.1 - 0.0064 16.4 0.5 15 5.6 0.0 4.1 5 0 0 5 5 5 2 Domain of unknown function (DUF5049) Ank_4 PF13637.6 EFA75795.1 - 2e-19 69.7 8.3 0.00084 19.9 0.0 9.3 5 2 3 9 9 9 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75795.1 - 1.9e-17 63.6 10.1 6.8e-05 23.4 0.0 6.9 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75795.1 - 7.9e-11 42.0 4.4 0.69 10.3 0.0 9.6 5 1 3 10 10 10 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75795.1 - 2.7e-10 39.6 2.1 22 6.0 0.0 11.6 14 0 0 14 14 14 0 Ankyrin repeat DUF5049 PF16468.5 EFA75795.1 - 0.00045 20.1 0.1 21 5.1 0.0 5.5 6 0 0 6 6 6 0 Domain of unknown function (DUF5049) BTHB PF18410.1 EFA75795.1 - 0.016 15.0 4.2 7.4 6.5 0.0 6.7 8 2 2 10 10 10 0 Basic tilted helix bundle domain Ank PF00023.30 EFA75795.1 - 0.021 15.3 0.8 1.9e+02 2.7 0.0 6.3 9 1 0 9 9 9 0 Ankyrin repeat Pox_A3L PF05288.11 EFA75795.1 - 0.028 14.4 0.1 1.7 8.7 0.0 3.7 3 0 0 3 3 3 0 Poxvirus A3L Protein Baculo_19 PF04798.12 EFA75795.1 - 0.092 12.5 5.5 0.71 9.6 0.0 4.2 4 1 0 4 4 4 0 Baculovirus 19 kDa protein conserved region DUF4927 PF16279.5 EFA75795.1 - 0.099 13.7 0.1 21 6.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4927) Ank_4 PF13637.6 EFA75796.1 - 5.6e-16 58.7 3.8 0.0038 17.8 0.0 8.3 6 3 3 9 9 9 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75796.1 - 2.4e-15 56.9 11.0 1.1e-06 29.1 0.1 5.5 2 2 5 7 7 7 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75796.1 - 6.5e-10 39.1 2.3 0.31 11.4 0.0 7.5 5 2 3 8 8 8 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75796.1 - 2.1e-09 36.8 3.8 1.3 9.8 0.0 9.5 13 0 0 13 13 13 1 Ankyrin repeat DUF1843 PF08898.10 EFA75796.1 - 0.00044 20.7 0.0 11 6.7 0.0 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF1843) Ank PF00023.30 EFA75796.1 - 0.0056 17.1 0.2 2.7 8.6 0.1 4.6 4 1 0 4 4 4 1 Ankyrin repeat CDP-OH_P_transf PF01066.21 EFA75797.1 - 1.3e-18 67.5 0.1 1.3e-18 67.5 0.1 4.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DHHC PF01529.20 EFA75798.1 - 0.0029 17.7 1.3 0.0029 17.7 1.3 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2208 PF09973.9 EFA75798.1 - 0.038 13.6 0.3 0.046 13.3 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Fip1 PF05182.13 EFA75798.1 - 1.2 8.8 5.0 2.6 7.6 5.0 1.5 1 0 0 1 1 1 0 Fip1 motif DUF485 PF04341.12 EFA75798.1 - 4.3 7.4 6.6 7.4 6.6 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF1053 PF06327.14 EFA75799.1 - 2.9 8.5 6.9 0.53 10.9 0.7 2.7 1 1 0 2 2 2 0 Domain of Unknown Function (DUF1053) Pkinase PF00069.25 EFA75800.1 - 1.6e-61 208.0 0.0 2.1e-61 207.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75800.1 - 3e-50 170.9 0.0 4.3e-50 170.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA75800.1 - 0.00036 19.9 0.0 0.0026 17.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFA75800.1 - 0.00046 19.1 0.0 0.00075 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFA75800.1 - 0.018 14.7 0.1 0.053 13.1 0.1 1.7 1 1 1 2 2 2 0 RIO1 family FTA2 PF13095.6 EFA75800.1 - 0.031 13.9 0.0 1.9 8.1 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFA75800.1 - 0.098 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA75800.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cofilin_ADF PF00241.20 EFA75801.1 - 1.8e-26 92.3 0.0 2e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PI3_PI4_kinase PF00454.27 EFA75802.1 - 3.2e-36 125.4 5.0 3.8e-34 118.6 0.4 3.7 3 1 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFA75802.1 - 0.0013 18.2 2.1 0.002 17.5 0.2 2.2 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) F-box_5 PF18511.1 EFA75802.1 - 0.0078 15.8 0.5 0.022 14.3 0.5 1.7 1 0 0 1 1 1 1 F-box Trypan_PARP PF05887.11 EFA75802.1 - 0.1 12.6 10.1 0.19 11.7 10.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2058 PF09831.9 EFA75802.1 - 3.4 7.8 22.6 0.83 9.8 10.2 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2058) 4HBT PF03061.22 EFA75803.1 - 2.4e-12 47.0 0.0 3.4e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Sortilin-Vps10 PF15902.5 EFA75804.1 - 6.3e-60 203.2 0.7 8e-60 202.9 0.7 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EFA75804.1 - 2.4e-22 80.1 0.0 3.4e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EFA75804.1 - 0.0026 17.5 20.6 0.064 13.3 0.6 6.5 6 0 0 6 6 6 3 BNR/Asp-box repeat BNR_6 PF15899.5 EFA75804.1 - 0.0061 16.5 0.5 19 5.7 0.0 4.4 4 0 0 4 4 4 1 BNR-Asp box repeat F-box_5 PF18511.1 EFA75806.1 - 1.2e-05 24.7 0.1 3.6e-05 23.3 0.1 1.8 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75806.1 - 0.0024 17.7 0.2 0.0081 16.0 0.2 1.9 1 0 0 1 1 1 1 F-box-like Phage_G PF02306.15 EFA75806.1 - 0.025 14.3 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Major spike protein (G protein) FBA_2 PF07735.17 EFA75806.1 - 0.28 11.4 4.6 0.24 11.5 1.4 2.2 2 0 0 2 2 2 0 F-box associated FNIP PF05725.12 EFA75807.1 - 7.4e-09 35.6 21.8 0.00013 22.1 0.1 6.1 4 1 4 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA75807.1 - 3.9e-05 23.1 0.1 7.4e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75807.1 - 0.0014 18.5 0.5 0.0054 16.6 0.5 2.0 1 0 0 1 1 1 1 F-box-like Apis_Csd PF11671.8 EFA75807.1 - 0.37 10.8 5.6 0.68 9.9 5.6 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein FNIP PF05725.12 EFA75808.1 - 5.3e-30 103.3 13.4 7.7e-11 42.0 1.3 9.3 10 2 1 11 11 11 6 FNIP Repeat F-box_5 PF18511.1 EFA75808.1 - 0.00022 20.7 0.6 0.00048 19.6 0.6 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75808.1 - 0.001 18.9 0.8 0.0033 17.3 0.8 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75808.1 - 0.026 14.4 0.7 0.088 12.7 0.7 1.9 1 0 0 1 1 1 0 F-box domain LRR_4 PF12799.7 EFA75808.1 - 0.076 13.5 18.1 0.45 11.0 0.3 6.9 6 1 0 6 6 6 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 EFA75810.1 - 4e-16 58.9 50.0 5.2e-09 36.1 0.9 9.2 9 1 1 10 10 10 5 FNIP Repeat F-box_5 PF18511.1 EFA75810.1 - 4.3e-06 26.2 0.4 1.1e-05 24.9 0.4 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75810.1 - 0.00042 20.1 0.2 0.0018 18.1 0.2 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75810.1 - 0.027 14.4 0.1 0.09 12.7 0.1 1.9 1 0 0 1 1 1 0 F-box domain FNIP PF05725.12 EFA75811.1 - 1.2e-18 67.0 17.9 1.2e-06 28.5 0.1 8.5 6 3 4 10 10 10 6 FNIP Repeat F-box_5 PF18511.1 EFA75811.1 - 6.3e-05 22.5 0.3 0.00015 21.2 0.3 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75811.1 - 0.00076 19.3 0.4 0.0021 17.9 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA75811.1 - 0.013 15.3 0.2 0.049 13.5 0.2 1.9 1 0 0 1 1 1 0 F-box domain FNIP PF05725.12 EFA75812.1 - 2.3e-25 88.5 34.2 5e-09 36.2 0.3 8.8 10 2 0 10 10 10 5 FNIP Repeat F-box_5 PF18511.1 EFA75812.1 - 0.028 14.0 0.1 0.069 12.7 0.1 1.6 1 0 0 1 1 1 0 F-box ApoLp-III PF07464.11 EFA75812.1 - 0.24 11.5 0.1 0.92 9.6 0.0 1.8 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) GST_N_2 PF13409.6 EFA75813.1 - 1.3e-21 76.7 0.0 3.4e-21 75.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA75813.1 - 9e-15 54.5 0.1 1.6e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA75813.1 - 2.3e-09 37.4 0.0 3.5e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA75813.1 - 5.5e-05 23.5 0.0 0.0015 18.9 0.0 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA75813.1 - 6.8e-05 23.0 0.1 0.00013 22.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA75813.1 - 0.00092 19.0 0.2 0.002 17.8 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Orthopox_A43R PF06517.11 EFA75813.1 - 0.049 13.5 1.8 0.083 12.7 0.5 1.9 1 1 1 2 2 2 0 Orthopoxvirus A43R protein Endotoxin_N PF03945.14 EFA75814.1 - 0.0012 18.6 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Cm_res_leader PF08077.11 EFA75814.1 - 0.77 10.0 0.1 0.77 10.0 0.1 2.3 3 0 0 3 3 3 0 Chloramphenicol resistance gene leader peptide FNIP PF05725.12 EFA75815.1 - 1.7e-18 66.5 34.2 5.4e-08 32.9 0.4 9.3 8 3 4 13 13 13 4 FNIP Repeat F-box_5 PF18511.1 EFA75815.1 - 0.015 14.8 0.1 0.038 13.6 0.1 1.6 1 0 0 1 1 1 0 F-box ApoLp-III PF07464.11 EFA75815.1 - 0.22 11.6 0.1 0.87 9.7 0.0 1.9 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) GST_N_2 PF13409.6 EFA75816.1 - 3.2e-22 78.6 0.0 8.2e-22 77.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA75816.1 - 9e-15 54.5 0.1 1.6e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA75816.1 - 2.3e-09 37.4 0.0 3.5e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA75816.1 - 3.7e-05 24.1 0.0 0.0008 19.8 0.0 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA75816.1 - 6.9e-05 23.0 0.1 0.00013 22.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA75816.1 - 0.00092 19.0 0.2 0.0021 17.8 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Orthopox_A43R PF06517.11 EFA75816.1 - 0.021 14.6 1.3 0.046 13.5 0.3 1.9 1 1 1 2 2 2 0 Orthopoxvirus A43R protein Endotoxin_N PF03945.14 EFA75817.1 - 0.0045 16.7 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Cm_res_leader PF08077.11 EFA75817.1 - 0.3 11.3 1.0 0.77 10.0 0.1 2.3 2 0 0 2 2 2 0 Chloramphenicol resistance gene leader peptide FNIP PF05725.12 EFA75818.1 - 1.5e-46 156.2 62.7 6.7e-11 42.2 0.2 14.8 11 2 2 14 14 14 11 FNIP Repeat F-box_5 PF18511.1 EFA75818.1 - 7.2e-07 28.7 2.8 0.023 14.3 0.7 2.5 2 0 0 2 2 2 2 F-box F-box-like PF12937.7 EFA75818.1 - 0.00025 20.9 1.0 0.79 9.7 0.0 2.8 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EFA75818.1 - 0.067 13.1 0.3 3.2 7.7 0.1 2.8 2 0 0 2 2 2 0 F-box domain DDE_1 PF03184.19 EFA75819.1 - 2.5e-08 33.8 1.4 4.4e-08 33.0 1.4 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 EFA75819.1 - 0.00071 19.3 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_19 PF12844.7 EFA75819.1 - 0.0048 16.9 3.3 0.027 14.5 0.3 2.6 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_3 PF01381.22 EFA75819.1 - 0.0055 16.7 0.1 0.094 12.8 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.6 EFA75819.1 - 0.0081 16.1 0.2 0.017 15.1 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 EFA75819.1 - 0.016 14.8 0.0 0.27 10.8 0.0 2.8 2 1 1 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_26 PF13443.6 EFA75819.1 - 0.084 13.3 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain Sigma70_r4 PF04545.16 EFA75819.1 - 0.15 11.6 0.5 0.86 9.2 0.1 2.1 1 1 1 2 2 2 0 Sigma-70, region 4 HTH_Tnp_4 PF13613.6 EFA75820.1 - 4.8e-14 51.8 0.1 8.7e-14 51.0 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DUF2052 PF09747.9 EFA75820.1 - 0.014 15.5 0.4 0.023 14.8 0.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SARAF PF06682.12 EFA75820.1 - 0.044 13.4 0.2 0.063 12.9 0.2 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis RR_TM4-6 PF06459.12 EFA75820.1 - 0.1 12.4 2.8 0.15 11.8 2.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EFA75820.1 - 0.14 10.4 2.1 0.19 10.0 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein CCDC53 PF10152.9 EFA75820.1 - 0.21 12.0 1.8 0.38 11.1 1.8 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex FAM176 PF14851.6 EFA75820.1 - 0.35 10.5 2.1 0.68 9.6 2.1 1.5 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 EFA75820.1 - 0.85 10.0 6.0 0.89 10.0 4.3 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain eIF3_subunit PF08597.10 EFA75820.1 - 5.8 6.7 14.0 9.2 6.1 14.0 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Sporozoite_P67 PF05642.11 EFA75820.1 - 9.4 4.2 7.7 13 3.7 7.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dyp_perox PF04261.12 EFA75823.1 - 9.6e-77 258.1 0.0 1.4e-76 257.7 0.0 1.2 1 0 0 1 1 1 1 Dyp-type peroxidase family tRNA_U5-meth_tr PF05958.11 EFA75823.1 - 1.3e-23 83.5 1.0 4.6e-13 48.9 0.1 2.4 1 1 1 2 2 2 2 tRNA (Uracil-5-)-methyltransferase RrnaAD PF00398.20 EFA75823.1 - 5.2e-06 25.7 0.0 9.8e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 EFA75823.1 - 0.0013 18.5 0.0 0.012 15.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA75823.1 - 0.0022 18.7 0.0 0.008 16.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EFA75823.1 - 0.006 16.4 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EFA75823.1 - 0.018 14.6 0.0 0.048 13.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_15 PF09445.10 EFA75823.1 - 0.02 14.5 1.0 0.24 11.0 0.0 2.7 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase ATP13 PF12921.7 EFA75823.1 - 0.061 13.2 0.0 3.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial ATPase expression Methyltransf_11 PF08241.12 EFA75823.1 - 0.11 13.2 0.0 0.39 11.4 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain RNA_pol_Rpb1_5 PF04998.17 EFA75824.1 - 6.7e-92 307.7 0.3 2.3e-91 305.9 0.3 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFA75824.1 - 3.6e-60 203.0 0.0 7.4e-60 201.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EFA75824.1 - 1.8e-32 112.9 8.6 2.6e-31 109.1 8.6 2.4 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 EFA75824.1 - 4.2e-32 111.3 0.0 1.4e-31 109.5 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFA75824.1 - 7.8e-23 80.5 0.3 5.1e-22 77.9 0.0 2.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 BUD22 PF09073.10 EFA75824.1 - 0.00032 20.2 50.5 0.00074 19.0 23.2 2.2 2 0 0 2 2 2 2 BUD22 Nop14 PF04147.12 EFA75824.1 - 0.014 13.6 61.6 0.0069 14.7 33.7 2.1 2 0 0 2 2 2 0 Nop14-like family Presenilin PF01080.17 EFA75824.1 - 9.1 4.9 31.6 3 6.5 9.9 2.2 2 0 0 2 2 2 0 Presenilin Isy1 PF06246.12 EFA75825.1 - 1.2e-80 270.8 14.3 1.3e-80 270.6 14.3 1.0 1 0 0 1 1 1 1 Isy1-like splicing family BET PF17035.5 EFA75825.1 - 0.098 12.8 2.5 0.15 12.3 0.8 2.2 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation DUF1754 PF08555.10 EFA75825.1 - 0.77 10.6 11.9 0.36 11.7 9.5 1.7 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Far-17a_AIG1 PF04750.14 EFA75826.1 - 2.3e-26 92.4 15.5 9.1e-26 90.4 15.2 2.2 1 1 0 1 1 1 1 FAR-17a/AIG1-like protein ARL6IP6 PF15062.6 EFA75826.1 - 1.4 9.1 4.3 4.4 7.5 0.1 3.0 2 2 2 4 4 4 0 Haemopoietic lineage transmembrane helix Brix PF04427.18 EFA75827.1 - 6.1e-44 150.4 0.2 1e-43 149.7 0.2 1.3 1 0 0 1 1 1 1 Brix domain VSG_B PF13206.6 EFA75827.1 - 0.26 10.5 11.3 0.42 9.8 6.6 2.1 2 0 0 2 2 2 0 Trypanosomal VSG domain PSI_integrin PF17205.3 EFA75828.1 - 0.0086 15.8 5.1 0.019 14.7 5.1 1.6 1 0 0 1 1 1 1 Integrin plexin domain Maf PF02545.14 EFA75829.1 - 2.5e-51 173.8 0.0 4e-51 173.2 0.0 1.3 1 0 0 1 1 1 1 Maf-like protein FNIP PF05725.12 EFA75831.1 - 3.4e-22 78.3 33.8 5.5e-11 42.5 0.2 10.2 7 1 4 11 11 11 8 FNIP Repeat F-box_5 PF18511.1 EFA75831.1 - 2.1e-05 24.0 0.3 4.6e-05 22.9 0.3 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75831.1 - 0.0067 16.3 0.3 0.018 15.0 0.3 1.6 1 0 0 1 1 1 1 F-box-like FNIP PF05725.12 EFA75832.1 - 2.8e-28 97.8 5.6 6.4e-10 39.0 0.0 7.0 4 1 2 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA75832.1 - 5.1e-06 25.9 0.2 1.2e-05 24.8 0.2 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA75832.1 - 0.0003 20.6 0.6 0.00073 19.4 0.6 1.7 1 0 0 1 1 1 1 F-box-like FNIP PF05725.12 EFA75833.1 - 5.2e-22 77.7 10.3 1.8e-10 40.8 1.2 8.7 8 1 2 10 10 10 5 FNIP Repeat F-box_5 PF18511.1 EFA75833.1 - 0.00012 21.5 1.2 0.00037 20.0 1.2 1.7 1 0 0 1 1 1 1 F-box DUF1793 PF08760.11 EFA75833.1 - 0.006 17.0 6.5 0.014 15.8 6.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) LRR_1 PF00560.33 EFA75833.1 - 0.68 10.7 7.1 4.5 8.2 0.3 5.3 4 1 0 4 4 4 0 Leucine Rich Repeat FNIP PF05725.12 EFA75834.1 - 3.1e-28 97.7 36.5 1.9e-06 27.9 1.4 9.2 7 3 3 10 10 10 8 FNIP Repeat F-box_5 PF18511.1 EFA75834.1 - 5.1e-06 25.9 1.2 1e-05 25.0 1.2 1.4 1 0 0 1 1 1 1 F-box PH_16 PF17838.1 EFA75834.1 - 0.018 14.9 0.3 0.039 13.8 0.1 1.7 2 0 0 2 2 2 0 PH domain F-box PF00646.33 EFA75834.1 - 0.089 12.7 0.5 0.21 11.5 0.5 1.6 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFA75834.1 - 0.12 12.3 1.5 0.29 11.0 1.5 1.6 1 0 0 1 1 1 0 F-box-like DUF4397 PF14344.6 EFA75835.1 - 8.1e-05 23.4 0.2 8.1e-05 23.4 0.2 6.2 6 2 0 6 6 6 2 Domain of unknown function (DUF4397) Peptidase_C12 PF01088.21 EFA75836.1 - 1.9e-67 227.1 0.0 3.1e-67 226.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Kelch_6 PF13964.6 EFA75838.1 - 1.4e-14 53.8 8.6 1e-07 32.0 0.1 4.5 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EFA75838.1 - 0.0082 15.7 1.3 0.052 13.1 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 EFA75838.1 - 0.034 14.1 3.2 1.2 9.3 0.1 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 EFA75838.1 - 3.7 7.6 9.4 1 9.4 0.2 3.6 4 0 0 4 4 4 0 Kelch motif Ank_2 PF12796.7 EFA75839.1 - 5.9e-25 87.7 6.4 8.7e-08 32.7 0.0 5.4 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75839.1 - 4.9e-21 74.8 12.4 0.00017 22.1 0.4 9.8 6 3 5 11 11 11 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75839.1 - 2.4e-16 59.6 6.6 1.5 9.2 0.0 11.3 3 2 9 12 12 12 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75839.1 - 1.9e-15 55.4 0.4 7.3 7.5 0.0 10.9 12 0 0 12 12 12 3 Ankyrin repeat DUF1843 PF08898.10 EFA75839.1 - 0.0037 17.7 0.0 0.85 10.2 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF1843) T3SS_ATPase_C PF18269.1 EFA75839.1 - 0.012 15.4 0.0 2.4 8.1 0.1 3.4 3 0 0 3 3 3 0 T3SS EscN ATPase C-terminal domain GATase PF00117.28 EFA75840.1 - 4e-36 124.6 0.0 9e-36 123.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 EFA75840.1 - 9.8e-19 67.2 1.6 1e-11 44.7 0.0 3.5 3 1 0 3 3 3 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 EFA75840.1 - 5.5e-12 45.9 0.1 1.3e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 EFA75840.1 - 4.1e-09 35.9 0.0 5e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 NAD synthase QueC PF06508.13 EFA75840.1 - 6.4e-07 29.1 0.1 1.1e-05 25.0 0.1 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 EFA75840.1 - 6.1e-05 22.5 0.1 0.0001 21.7 0.1 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase ThiI PF02568.14 EFA75840.1 - 8e-05 22.3 0.0 0.00032 20.4 0.1 2.0 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EFA75840.1 - 0.00012 21.0 0.0 0.00098 18.0 0.1 2.0 2 0 0 2 2 2 1 tRNA methyl transferase HAD PF12710.7 EFA75840.1 - 0.00051 20.5 0.1 1.6 9.1 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase PAPS_reduct PF01507.19 EFA75840.1 - 0.001 19.2 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Asn_synthase PF00733.21 EFA75840.1 - 0.0037 17.0 0.0 0.0061 16.3 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.20 EFA75840.1 - 0.033 14.0 0.1 0.085 12.6 0.0 1.7 2 0 0 2 2 2 0 PP-loop family 7tm_4 PF13853.6 EFA75840.1 - 0.047 13.4 0.1 0.075 12.8 0.1 1.2 1 0 0 1 1 1 0 Olfactory receptor Aminotran_4 PF01063.19 EFA75841.1 - 3.2e-31 108.9 0.0 4.1e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV CBM49 PF09478.10 EFA75842.1 - 1.8e-14 53.8 0.6 2.5e-14 53.3 0.6 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 GPR15L PF15854.5 EFA75842.1 - 0.074 13.3 0.1 0.11 12.8 0.1 1.2 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 CBM_2 PF00553.19 EFA75842.1 - 0.11 12.8 0.1 0.16 12.3 0.1 1.3 1 0 0 1 1 1 0 Cellulose binding domain GyrI-like PF06445.15 EFA75843.1 - 8.3e-24 84.6 0.0 5.1e-21 75.6 0.1 2.0 1 1 1 2 2 2 2 GyrI-like small molecule binding domain Cass2 PF14526.6 EFA75843.1 - 1.9e-11 44.4 0.1 3.3e-11 43.6 0.1 1.6 1 1 0 1 1 1 1 Integron-associated effector binding protein Ank_2 PF12796.7 EFA75844.1 - 1.3e-15 57.8 7.3 0.00065 20.2 0.1 5.1 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75844.1 - 3.6e-10 39.9 0.6 0.26 11.7 0.0 6.4 5 1 2 7 7 7 2 Ankyrin repeats (many copies) F-box_5 PF18511.1 EFA75844.1 - 2.8e-08 33.2 0.6 7.3e-08 31.9 0.6 1.6 1 0 0 1 1 1 1 F-box Ank_4 PF13637.6 EFA75844.1 - 8.6e-08 32.6 4.0 1.6 9.4 0.2 7.3 6 3 2 8 8 8 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75844.1 - 2.3e-07 30.5 4.0 17 6.4 0.0 7.9 10 0 0 10 10 10 1 Ankyrin repeat F-box-like PF12937.7 EFA75844.1 - 0.00059 19.7 1.8 0.0012 18.7 0.4 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA75844.1 - 0.0057 16.5 0.3 0.017 15.0 0.3 1.8 1 0 0 1 1 1 1 F-box domain FNIP PF05725.12 EFA75845.1 - 8.5e-22 77.1 17.9 7.9e-09 35.5 1.0 9.9 9 2 4 13 13 13 7 FNIP Repeat F-box-like PF12937.7 EFA75845.1 - 0.00044 20.1 0.3 0.0017 18.2 0.3 2.0 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA75845.1 - 0.002 17.6 0.6 0.0042 16.6 0.6 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 EFA75845.1 - 0.0038 17.1 0.4 0.014 15.3 0.1 2.2 2 0 0 2 2 2 1 F-box domain Ank_2 PF12796.7 EFA75846.1 - 2.9e-23 82.3 5.1 1.3e-06 28.9 0.1 6.1 3 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75846.1 - 4.5e-21 74.9 3.3 0.0075 16.8 0.0 8.6 6 3 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75846.1 - 1.7e-15 56.9 1.9 0.094 13.1 0.0 8.7 5 2 5 10 10 10 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75846.1 - 1.9e-09 36.9 0.5 2.2 9.1 0.0 9.1 12 0 0 12 12 12 1 Ankyrin repeat DUF5049 PF16468.5 EFA75846.1 - 0.00024 20.9 0.2 10 6.1 0.0 5.1 3 1 2 5 5 5 1 Domain of unknown function (DUF5049) TSLP PF15216.6 EFA75846.1 - 0.034 14.4 2.7 4.2 7.7 0.1 4.2 4 1 1 5 5 5 0 Thymic stromal lymphopoietin Ank PF00023.30 EFA75846.1 - 0.043 14.3 0.1 58 4.4 0.0 4.6 4 1 0 4 4 4 0 Ankyrin repeat Linker_histone PF00538.19 EFA75847.1 - 8.4e-23 80.5 0.4 8.4e-23 80.5 0.4 2.3 3 0 0 3 3 3 1 linker histone H1 and H5 family LZ3wCH PF18517.1 EFA75847.1 - 0.95 9.6 0.0 0.95 9.6 0.0 2.9 4 0 0 4 4 4 0 Leucine zipper with capping helix domain FAD_binding_6 PF00970.24 EFA75848.1 - 4.4e-33 113.6 0.0 7.3e-33 112.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFA75848.1 - 2.2e-32 111.9 0.0 4.1e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFA75848.1 - 2.4e-06 27.8 0.0 0.00039 20.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Hus1 PF04005.12 EFA75849.1 - 2.8e-54 184.2 11.2 7.1e-53 179.6 11.2 2.0 1 1 0 1 1 1 1 Hus1-like protein Sen15 PF09631.10 EFA75849.1 - 0.011 16.1 1.1 0.27 11.6 0.1 2.5 1 1 1 2 2 2 0 Sen15 protein PH_RBD PF12068.8 EFA75849.1 - 0.063 12.8 0.8 0.099 12.1 0.3 1.6 2 0 0 2 2 2 0 Rab-binding domain (RBD) Ricin_B_lectin PF00652.22 EFA75851.1 - 0.054 13.7 0.3 0.18 12.1 0.1 1.9 2 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain Acetyltransf_CG PF14542.6 EFA75852.1 - 7.1e-25 86.9 0.0 9.2e-25 86.6 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.7 EFA75852.1 - 0.076 13.0 0.0 0.086 12.8 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 EFA75853.1 - 3.1e-31 107.8 4.8 5.5e-10 39.7 0.1 5.6 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75853.1 - 1.4e-25 89.3 6.9 7.6e-05 23.2 0.0 8.1 6 3 1 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75853.1 - 4.9e-25 87.3 10.4 0.04 14.2 0.1 10.1 3 1 8 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75853.1 - 1.8e-17 61.6 1.9 0.48 11.1 0.0 10.4 11 0 0 11 11 11 3 Ankyrin repeat Ank PF00023.30 EFA75853.1 - 0.0036 17.7 2.2 1.3e+02 3.3 0.1 7.0 5 2 1 6 6 6 0 Ankyrin repeat DUF5049 PF16468.5 EFA75853.1 - 0.0064 16.4 0.7 11 6.0 0.0 5.0 4 2 2 6 6 6 1 Domain of unknown function (DUF5049) DUF5515 PF17635.2 EFA75853.1 - 0.15 12.8 0.6 42 4.9 0.0 3.2 4 0 0 4 4 4 0 Family of unknown function (DUF5515) Ank_2 PF12796.7 EFA75854.1 - 2.8e-20 72.7 7.8 1.4e-05 25.5 0.0 5.4 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75854.1 - 2.9e-13 49.8 10.8 1.2 9.5 0.0 9.6 6 4 5 11 11 11 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75854.1 - 8.1e-12 44.2 11.1 6.2 7.7 0.0 9.7 10 0 0 10 10 10 4 Ankyrin repeat Ank_4 PF13637.6 EFA75854.1 - 1.9e-11 44.2 10.7 0.019 15.6 0.0 7.4 6 3 0 6 6 6 3 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA75854.1 - 5.2e-06 26.2 3.1 0.92 9.4 0.0 6.1 6 1 1 7 7 7 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA75854.1 - 0.28 11.7 7.6 49 4.6 0.0 7.0 3 2 1 4 4 4 0 Ankyrin repeat EGF_2 PF07974.13 EFA75855.1 - 0.0016 18.8 8.5 0.0016 18.8 8.5 1.9 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EFA75855.1 - 0.0057 16.9 5.9 0.0057 16.9 5.9 2.1 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 EFA75855.1 - 0.51 11.1 10.5 0.23 12.1 5.6 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF Toxin_2 PF00451.19 EFA75855.1 - 1.7 9.0 5.9 3.9 7.9 5.9 1.6 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 Plasmod_Pvs28 PF06247.11 EFA75855.1 - 3.8 7.9 9.1 28 5.1 6.4 3.0 2 0 0 2 2 2 0 Pvs28 EGF domain EGF_2 PF07974.13 EFA75856.1 - 0.0023 18.3 15.2 0.0061 16.9 15.2 1.8 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA75856.1 - 0.085 13.2 11.4 0.2 12.0 11.4 1.7 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 EFA75856.1 - 0.12 12.7 4.4 0.36 11.2 4.4 1.8 1 0 0 1 1 1 0 EB module hEGF PF12661.7 EFA75856.1 - 0.62 10.8 8.2 2 9.1 8.2 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF Mito_carr PF00153.27 EFA75857.1 - 6e-69 228.0 2.6 1.1e-23 83.0 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EFA75857.1 - 7.1e-25 87.3 8.0 3.5e-12 46.6 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFA75857.1 - 6.9e-24 81.6 8.6 7.7e-05 22.0 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 EFA75857.1 - 4.4e-22 76.5 12.5 1.7e-05 24.1 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EFA75857.1 - 3.2e-20 70.3 8.1 4.7e-05 23.0 0.2 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFA75857.1 - 6.8e-14 51.5 7.0 2.9e-05 23.8 0.2 4.3 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA75857.1 - 6.4e-13 49.0 3.4 1.3e-06 28.7 0.1 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EFA75857.1 - 0.0013 18.5 3.0 1.2 9.1 0.2 3.6 3 1 1 4 4 4 2 EF hand DUF2666 PF10869.8 EFA75857.1 - 0.029 14.6 2.7 1.2 9.4 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) EF-hand_9 PF14658.6 EFA75857.1 - 0.031 14.6 0.1 1.1 9.7 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain DNA_PPF PF02916.15 EFA75857.1 - 0.1 13.0 0.5 0.53 10.7 0.3 2.3 1 1 1 2 2 2 0 DNA polymerase processivity factor Caleosin PF05042.13 EFA75857.1 - 0.12 12.2 0.1 9.9 6.1 0.1 2.8 1 1 0 2 2 2 0 Caleosin related protein EF-hand_13 PF17958.1 EFA75857.1 - 0.15 11.9 0.0 1.9 8.4 0.0 2.5 1 1 1 2 2 2 0 EF-hand domain DUF3447 PF11929.8 EFA75857.1 - 0.16 12.0 0.8 4.8 7.2 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Dockerin_1 PF00404.18 EFA75857.1 - 1.5 9.1 5.9 10 6.4 1.9 3.3 2 1 1 3 3 3 0 Dockerin type I domain EF-hand_4 PF12763.7 EFA75857.1 - 6.7 6.7 7.1 57 3.7 0.3 3.1 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Kelch_6 PF13964.6 EFA75858.1 - 4.3e-16 58.6 1.8 5.3e-06 26.5 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 EFA75858.1 - 6.2e-16 58.1 1.8 0.0067 16.4 0.0 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain zf-B_box PF00643.24 EFA75858.1 - 2.1e-07 31.0 7.7 5.2e-07 29.7 7.7 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA75858.1 - 2.6e-07 30.7 0.1 0.58 10.5 0.1 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA75858.1 - 6.2e-07 29.1 2.8 0.89 9.6 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA75858.1 - 8.1e-07 28.5 1.6 0.41 10.3 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 EFA75858.1 - 0.0023 17.9 7.6 1.5 8.9 0.0 4.2 5 0 0 5 5 5 2 Kelch motif DUF1554 PF07588.11 EFA75859.1 - 0.064 13.1 0.3 0.17 11.7 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1554) YmgB PF10798.8 EFA75859.1 - 3.4 7.6 9.3 3.4 7.5 0.8 4.3 3 0 0 3 3 3 0 Biofilm development protein YmgB/AriR SUIM_assoc PF16619.5 EFA75859.1 - 4.9 7.3 14.9 0.35 11.0 0.8 2.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 EFA75860.1 - 8.2e-25 87.7 0.1 5.8e-24 84.9 0.1 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75860.1 - 1.4e-07 31.0 0.1 9.7e-07 28.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFA75860.1 - 0.26 11.2 0.0 0.73 9.7 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family FAD-oxidase_C PF02913.19 EFA75861.1 - 1.7e-62 211.3 0.0 2.8e-62 210.6 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFA75861.1 - 3.4e-36 124.1 0.0 5.6e-36 123.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Peptidase_M1 PF01433.20 EFA75862.1 - 1.8e-45 155.2 0.0 3e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EFA75862.1 - 2.3e-40 137.2 0.4 5.1e-40 136.1 0.4 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EFA75862.1 - 1.3e-22 80.9 0.3 1.3e-22 80.9 0.3 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Peptidase_M48 PF01435.18 EFA75862.1 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M48 Clat_adaptor_s PF01217.20 EFA75863.1 - 1.6e-14 54.0 5.6 1e-11 44.9 5.6 2.1 1 1 0 1 1 1 1 Clathrin adaptor complex small chain CBS PF00571.28 EFA75864.1 - 7.1e-19 68.0 3.1 1.5e-08 34.9 0.1 3.3 3 0 0 3 3 3 3 CBS domain TRAPP PF04051.16 EFA75865.1 - 5.4e-38 130.0 0.7 7.3e-38 129.6 0.7 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SOG2 PF10428.9 EFA75865.1 - 0.43 9.7 13.9 0.49 9.5 12.8 1.5 1 1 1 2 2 2 0 RAM signalling pathway protein RRM_1 PF00076.22 EFA75866.1 - 1.9e-17 62.8 0.4 4.3e-17 61.7 0.4 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BUD22 PF09073.10 EFA75866.1 - 3.1e-05 23.5 42.5 0.00081 18.8 29.6 2.5 1 1 1 2 2 2 2 BUD22 BSP_II PF05432.11 EFA75866.1 - 0.0036 17.0 25.2 0.0036 17.0 25.2 3.2 3 0 0 3 3 3 1 Bone sialoprotein II (BSP-II) RRM_5 PF13893.6 EFA75866.1 - 0.0038 16.8 0.3 0.011 15.3 0.3 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA75866.1 - 0.015 15.3 0.1 0.027 14.5 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFA75866.1 - 0.038 14.1 0.1 0.1 12.7 0.1 1.7 1 0 0 1 1 1 0 RNA recognition motif RL PF17797.1 EFA75866.1 - 0.047 13.6 0.3 0.11 12.4 0.3 1.6 1 1 0 1 1 1 0 RL domain RRN3 PF05327.11 EFA75866.1 - 7.6 4.9 13.0 16 3.9 13.0 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Adaptin_N PF01602.20 EFA75867.1 - 0.00018 20.2 0.4 0.00049 18.8 0.3 1.8 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EFA75867.1 - 0.00082 19.7 0.0 0.0057 17.0 0.0 2.2 2 0 0 2 2 2 1 HEAT repeats Arm PF00514.23 EFA75867.1 - 0.0026 17.7 0.0 0.02 14.9 0.0 2.4 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFA75867.1 - 0.0036 17.8 0.0 0.012 16.1 0.0 2.0 1 1 0 1 1 1 1 HEAT-like repeat RasGEF_N_2 PF14663.6 EFA75867.1 - 0.0049 17.2 0.2 0.024 15.0 0.0 2.2 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Cnd1 PF12717.7 EFA75867.1 - 0.006 16.6 0.1 0.006 16.6 0.1 2.7 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFA75867.1 - 0.0073 16.5 0.0 0.028 14.7 0.0 2.0 1 0 0 1 1 1 1 HEAT repeat DUF1635 PF07795.11 EFA75867.1 - 0.31 10.9 8.9 0.19 11.5 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) SR-25 PF10500.9 EFA75867.1 - 0.4 10.3 15.4 0.79 9.3 15.4 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RIFIN PF02009.16 EFA75867.1 - 1.8 8.4 7.6 0.59 10.0 0.6 2.2 2 0 0 2 2 2 0 Rifin YABBY PF04690.13 EFA75867.1 - 3.4 8.2 7.2 2.5 8.6 2.8 2.2 2 0 0 2 2 2 0 YABBY protein RabGAP-TBC PF00566.18 EFA75868.1 - 2.3e-07 30.7 1.6 2.3e-07 30.7 1.6 2.9 2 1 1 3 3 3 1 Rab-GTPase-TBC domain Presenilin PF01080.17 EFA75868.1 - 0.31 9.7 1.5 0.45 9.2 1.5 1.2 1 0 0 1 1 1 0 Presenilin Med3 PF11593.8 EFA75868.1 - 1.1 8.4 12.8 0.5 9.5 10.3 1.6 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DUF962 PF06127.11 EFA75869.1 - 4.2e-23 81.3 2.0 1.3e-22 79.7 2.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Inositol_P PF00459.25 EFA75870.1 - 1.1e-41 143.1 0.0 1.3e-41 142.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF2678 PF10856.8 EFA75870.1 - 0.029 14.3 0.0 8.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) LRR_6 PF13516.6 EFA75872.1 - 8.6e-34 112.7 50.6 2e-06 27.4 0.1 13.5 13 0 0 13 13 13 11 Leucine Rich repeat LRR_4 PF12799.7 EFA75872.1 - 0.037 14.5 0.0 0.037 14.5 0.0 10.4 7 3 5 12 12 12 0 Leucine Rich repeats (2 copies) TRPM_tetra PF16519.5 EFA75872.1 - 0.85 9.8 3.7 92 3.2 0.1 4.2 4 0 0 4 4 4 0 Tetramerisation domain of TRPM LRR_1 PF00560.33 EFA75872.1 - 1.4 9.8 39.8 21 6.2 0.0 10.8 10 2 0 10 10 10 0 Leucine Rich Repeat CoA_transf_3 PF02515.17 EFA75873.1 - 1.2e-114 383.3 0.0 1.5e-114 383.0 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III Oxidored_q4 PF00507.19 EFA75874.1 - 0.017 15.3 4.8 0.017 15.3 4.8 2.2 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Ac76 PF05814.11 EFA75874.1 - 0.045 13.8 6.3 0.47 10.5 0.2 2.4 2 0 0 2 2 2 0 Orf76 (Ac76) DUF4131 PF13567.6 EFA75874.1 - 0.19 11.4 1.1 1.1 8.9 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) LapA_dom PF06305.11 EFA75874.1 - 0.83 9.5 6.2 23 4.9 1.0 3.4 3 1 1 4 4 4 0 Lipopolysaccharide assembly protein A domain Claudin_2 PF13903.6 EFA75874.1 - 1.7 8.4 14.2 2.3 7.9 5.9 2.7 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction SapB_1 PF05184.15 EFA75875.1 - 1.1e-20 73.3 19.8 2.3e-12 46.6 2.6 5.2 6 0 0 6 6 6 3 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA75875.1 - 1.3e-14 54.0 3.4 4.7e-09 36.2 0.3 3.7 3 0 0 3 3 3 2 Saposin-like type B, region 2 Phage_GPD PF05954.11 EFA75875.1 - 0.025 13.9 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) AnfO_nitrog PF09582.10 EFA75875.1 - 0.11 11.9 2.7 0.16 11.3 0.3 2.4 2 1 1 3 3 3 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) GRP PF07172.11 EFA75875.1 - 0.17 12.6 13.3 1.9 9.2 0.1 2.4 2 0 0 2 2 2 0 Glycine rich protein family DUF2946 PF11162.8 EFA75875.1 - 0.41 11.3 3.1 4.3 8.0 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) ILEI PF15711.5 EFA75876.1 - 1.6e-08 34.9 0.3 2.2e-08 34.4 0.3 1.2 1 0 0 1 1 1 1 Interleukin-like EMT inducer RL11D PF11088.8 EFA75877.1 - 0.11 12.8 2.7 0.14 12.5 0.4 2.0 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 Trp_Tyr_perm PF03222.13 EFA75878.1 - 0.00022 20.4 1.9 0.00022 20.4 1.9 3.4 4 0 0 4 4 4 1 Tryptophan/tyrosine permease family DUF719 PF05334.13 EFA75878.1 - 1.3 9.2 10.3 0.34 11.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF719) MTS PF05175.14 EFA75879.1 - 1.7e-05 24.4 0.0 0.00033 20.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 EFA75879.1 - 0.038 13.4 0.2 2.3 7.5 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EFA75879.1 - 0.056 13.2 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 EFA75879.1 - 0.068 13.9 0.0 0.17 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Collagen PF01391.18 EFA75879.1 - 0.26 11.1 1.1 3.5 7.5 0.2 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) PAS PF00989.25 EFA75880.1 - 5.8e-08 32.7 0.1 0.006 16.6 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 EFA75880.1 - 2.4e-07 30.6 0.0 0.0043 17.1 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 EFA75880.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EFA75880.1 - 0.0087 16.3 0.3 0.059 13.6 0.0 2.4 2 0 0 2 2 2 1 PAS domain HATPase_c PF02518.26 EFA75880.1 - 0.4 11.2 5.6 0.62 10.6 3.7 2.4 2 1 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF423 PF04241.15 EFA75881.1 - 1e-24 86.5 0.5 1.5e-24 86.0 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF423) DUF2627 PF11118.8 EFA75881.1 - 0.66 10.6 3.4 14 6.3 3.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2627) Trp_dioxygenase PF03301.13 EFA75882.1 - 2.1e-81 274.0 1.6 3.2e-48 164.8 0.6 2.4 1 1 1 2 2 2 2 Tryptophan 2,3-dioxygenase Rubis-subs-bind PF09273.11 EFA75882.1 - 1.9e-08 35.1 0.0 4.7e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 EFA75882.1 - 0.031 14.6 0.0 0.094 13.1 0.0 1.9 2 0 0 2 2 2 0 SET domain RasGEF PF00617.19 EFA75883.1 - 7e-37 127.3 1.6 7e-37 127.3 1.6 2.5 2 0 0 2 2 2 1 RasGEF domain FNIP PF05725.12 EFA75883.1 - 7.8e-13 48.4 9.3 1.2e-08 35.0 2.0 4.7 3 1 1 4 4 4 2 FNIP Repeat LRR_4 PF12799.7 EFA75883.1 - 2.1e-11 43.8 22.2 0.00054 20.3 0.4 7.4 6 1 1 7 7 7 4 Leucine Rich repeats (2 copies) RasGEF_N PF00618.20 EFA75883.1 - 2.5e-10 40.5 0.9 2.5e-10 40.5 0.9 4.4 3 1 0 3 3 3 1 RasGEF N-terminal motif SNARE_assoc PF09335.11 EFA75884.1 - 0.00012 22.5 14.2 0.026 15.0 6.6 2.4 1 1 1 2 2 2 2 SNARE associated Golgi protein Dickkopf_N PF04706.12 EFA75884.1 - 0.11 13.0 59.5 0.95 10.0 0.7 8.2 6 3 1 7 7 7 0 Dickkopf N-terminal cysteine-rich region FOLN PF09289.10 EFA75884.1 - 6.8 7.0 64.0 1.4 9.2 1.4 8.3 8 0 0 8 8 8 0 Follistatin/Osteonectin-like EGF domain Kelch_6 PF13964.6 EFA75885.1 - 2.1e-08 34.2 3.8 0.0002 21.5 0.2 5.1 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA75885.1 - 6.7e-05 23.0 10.6 6.7e-05 23.0 10.6 2.0 2 0 0 2 2 2 1 B-box zinc finger Kelch_3 PF13415.6 EFA75885.1 - 0.051 13.9 0.1 1 9.7 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA75885.1 - 0.22 11.5 0.5 2.2 8.3 0.1 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF1378 PF07125.11 EFA75885.1 - 0.29 11.3 1.8 1.8 8.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1378) PHZA_PHZB PF03284.13 EFA75886.1 - 0.019 14.6 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Phenazine biosynthesis protein A/B SnoaL PF07366.12 EFA75886.1 - 0.027 14.3 0.2 0.25 11.2 0.1 2.1 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EFA75886.1 - 0.033 14.8 0.0 0.045 14.4 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain Acetyltransf_7 PF13508.7 EFA75886.1 - 0.056 13.9 0.0 0.071 13.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain STATa_Ig PF18214.1 EFA75887.1 - 9.1e-09 35.4 2.2 0.0016 18.4 0.0 2.5 1 1 1 2 2 2 2 STATa Immunoglobulin-like domain SR-25 PF10500.9 EFA75887.1 - 1.6 8.3 10.1 2.5 7.7 10.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1635 PF07795.11 EFA75887.1 - 2 8.2 8.2 3.7 7.4 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) GSH-S_ATP PF02955.16 EFA75888.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain FNIP PF05725.12 EFA75889.1 - 2.2e-13 50.1 0.9 1e-05 25.6 0.0 2.3 2 0 0 2 2 2 2 FNIP Repeat p450 PF00067.22 EFA75891.1 - 5e-92 309.0 0.1 5.9e-92 308.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Beta-Casp PF10996.8 EFA75892.1 - 3.1e-21 75.7 0.0 8e-21 74.4 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EFA75892.1 - 8.3e-19 67.8 0.1 3.2e-18 65.9 0.1 2.0 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EFA75892.1 - 2.7e-18 65.6 0.0 6.9e-18 64.3 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EFA75892.1 - 2.3e-11 44.1 0.1 4.6e-09 36.6 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFA75892.1 - 3.8e-06 26.6 0.0 0.0011 18.5 0.0 2.9 3 0 0 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFA75892.1 - 0.022 14.7 0.8 0.12 12.3 0.0 2.4 4 0 0 4 4 4 0 Beta-lactamase superfamily domain RANK_CRD_2 PF18278.1 EFA75892.1 - 0.058 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 DUF4493 PF14900.6 EFA75892.1 - 0.082 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) FR47 PF08445.10 EFA75893.1 - 1.3e-15 57.1 0.0 2.4e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 EFA75893.1 - 3.9e-06 27.1 0.0 6.5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA75893.1 - 5e-05 23.2 0.0 9.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA75893.1 - 0.00078 20.1 0.0 0.0013 19.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Gly_acyl_tr_C PF08444.10 EFA75893.1 - 0.00087 19.5 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Acetyltransf_7 PF13508.7 EFA75893.1 - 0.0015 18.9 0.0 0.0027 18.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFA75893.1 - 0.0065 16.0 0.1 0.01 15.4 0.1 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase GNAT_acetyltran PF12746.7 EFA75893.1 - 0.015 14.9 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 GNAT acetyltransferase Dicty_CTDC PF00526.18 EFA75894.1 - 8.8e-41 137.4 188.0 1.1e-08 34.8 6.6 13.6 13 1 1 14 14 14 11 Dictyostelium (slime mold) repeat FNIP PF05725.12 EFA75895.1 - 7.1e-22 77.3 35.6 1.8e-10 40.8 2.1 7.4 5 2 3 8 8 8 7 FNIP Repeat F-box_5 PF18511.1 EFA75895.1 - 0.19 11.3 0.2 0.48 10.0 0.2 1.7 1 0 0 1 1 1 0 F-box DUF4419 PF14388.6 EFA75896.1 - 9.4e-83 278.1 7.0 7.3e-80 268.6 7.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4419) Dicty_CTDC PF00526.18 EFA75897.1 - 1.2e-35 121.0 184.7 1.1e-08 34.9 6.6 13.6 13 1 1 14 14 14 11 Dictyostelium (slime mold) repeat Complex1_LYR PF05347.15 EFA75898.1 - 0.0032 17.5 0.5 0.005 16.9 0.5 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Cwf_Cwc_15 PF04889.12 EFA75899.1 - 1.3e-49 169.1 55.8 1.7e-49 168.8 55.8 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TSP9 PF11493.8 EFA75899.1 - 0.46 11.2 4.9 0.32 11.7 0.4 2.4 2 0 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 Nop14 PF04147.12 EFA75899.1 - 0.5 8.5 55.9 0.65 8.1 55.9 1.1 1 0 0 1 1 1 0 Nop14-like family WD40 PF00400.32 EFA75900.1 - 1.3e-46 155.6 17.0 1.9e-09 38.0 0.1 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA75900.1 - 2.4e-13 50.2 0.9 0.00092 19.5 0.2 5.2 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA75900.1 - 2.2e-08 33.4 0.2 0.028 13.4 0.0 4.7 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFA75900.1 - 1.2e-07 30.8 0.6 0.38 9.3 0.1 4.7 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFA75900.1 - 0.00044 19.1 0.2 1.2 7.7 0.0 4.3 1 1 2 5 5 5 1 Nup133 N terminal like Cytochrom_D1 PF02239.16 EFA75900.1 - 0.00058 18.5 0.0 1 7.8 0.0 3.0 3 0 0 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 EFA75900.1 - 0.0061 15.5 1.6 0.012 14.6 0.1 2.2 2 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EFA75900.1 - 0.077 11.3 0.0 0.44 8.8 0.0 2.0 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EFA75900.1 - 0.089 12.1 0.0 7.6 5.8 0.0 2.2 1 1 0 2 2 2 0 WD40-like domain Hira PF07569.11 EFA75900.1 - 0.13 12.0 2.3 1.2 8.8 0.3 3.4 3 1 0 3 3 3 0 TUP1-like enhancer of split Cytochrom_C1 PF02167.15 EFA75901.1 - 8.4e-89 297.0 0.0 1.2e-88 296.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EFA75901.1 - 0.0015 18.8 0.0 0.003 17.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EFA75901.1 - 0.12 13.5 0.0 0.3 12.3 0.0 1.8 1 0 0 1 1 1 0 Cytochrome c UQ_con PF00179.26 EFA75902.1 - 1.3e-08 34.6 0.2 3.7e-08 33.1 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Ldh_1_C PF02866.18 EFA75903.1 - 2.8e-33 115.2 0.0 4.2e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFA75903.1 - 8.1e-30 103.8 0.0 1.3e-29 103.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 EFA75904.1 - 3e-47 161.2 0.2 4.6e-47 160.6 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFA75904.1 - 1.2e-46 158.6 0.1 1.7e-46 158.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFA75904.1 - 5.2e-09 36.3 0.2 8.6e-09 35.5 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA75904.1 - 5.2e-05 22.8 0.0 7.6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA75904.1 - 0.042 12.8 2.6 0.049 12.6 0.3 2.0 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Aldo_ket_red PF00248.21 EFA75905.1 - 5.1e-46 157.2 0.1 4.4e-44 150.8 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Ank_4 PF13637.6 EFA75906.1 - 0.2 12.3 4.9 1.3 9.7 0.0 4.0 5 1 0 5 5 5 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75907.1 - 4.4e-05 24.0 0.5 0.48 11.1 0.0 3.9 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75907.1 - 5.1e-05 23.8 0.1 0.025 15.2 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeats (many copies) TetR_C_5 PF08360.11 EFA75907.1 - 0.069 13.3 0.4 0.069 13.3 0.4 2.2 2 0 0 2 2 2 0 QacR-like protein, C-terminal region Pkinase PF00069.25 EFA75910.1 - 1.2e-55 188.7 0.2 1.3e-54 185.3 0.2 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA75910.1 - 4.7e-22 78.5 0.5 1.2e-12 47.7 0.1 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA75910.1 - 0.00028 20.3 0.1 0.26 10.6 0.1 3.2 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFA75910.1 - 0.027 13.8 0.3 0.13 11.6 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA75910.1 - 0.036 14.0 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L7Ae PF01248.26 EFA75911.1 - 2.2e-18 65.8 5.9 7.6e-18 64.0 5.9 1.8 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family S-methyl_trans PF02574.16 EFA75911.1 - 0.093 12.5 0.0 0.099 12.4 0.0 1.2 1 0 0 1 1 1 0 Homocysteine S-methyltransferase zf-C2H2_jaz PF12171.8 EFA75912.1 - 0.0017 18.6 1.2 0.0066 16.7 1.2 2.1 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding ARS2 PF04959.13 EFA75912.1 - 0.0052 17.2 0.1 0.0052 17.2 0.1 1.5 2 0 0 2 2 2 1 Arsenite-resistance protein 2 LRR19-TM PF15176.6 EFA75912.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Gemini_mov PF01708.16 EFA75912.1 - 0.042 13.6 0.6 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Geminivirus putative movement protein 7TM_GPCR_Str PF10326.9 EFA75912.1 - 0.087 12.2 3.3 0.039 13.3 0.7 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str Adeno_E3_CR2 PF02439.15 EFA75912.1 - 1.5 8.7 7.3 3 7.7 4.6 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 p450 PF00067.22 EFA75913.1 - 4.9e-77 259.6 0.4 6.3e-77 259.3 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3760 PF12586.8 EFA75913.1 - 0.079 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) p450 PF00067.22 EFA75914.1 - 1.5e-82 277.8 0.2 1.9e-82 277.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 T4_Gp59_N PF08993.10 EFA75914.1 - 0.075 13.5 0.4 0.7 10.3 0.1 2.6 3 0 0 3 3 3 0 T4 gene Gp59 loader of gp41 DNA helicase NAD_binding_6 PF08030.12 EFA75915.1 - 8e-31 107.3 0.0 1.7e-30 106.2 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EFA75915.1 - 1.5e-19 70.4 9.4 4e-19 68.9 9.4 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EFA75915.1 - 1.9e-17 63.3 0.0 5.2e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain fn3 PF00041.21 EFA75915.1 - 6e-06 26.5 6.0 1.6 9.1 0.0 6.8 6 0 0 6 6 6 1 Fibronectin type III domain EGF_2 PF07974.13 EFA75915.1 - 6.7e-06 26.4 32.3 0.00029 21.2 8.1 3.3 3 0 0 3 3 3 2 EGF-like domain SKG6 PF08693.10 EFA75915.1 - 0.00032 20.0 9.7 0.16 11.4 4.1 2.5 2 0 0 2 2 2 2 Transmembrane alpha-helix domain Protocadherin PF08374.11 EFA75915.1 - 0.00047 20.2 1.7 0.23 11.4 0.5 2.4 2 0 0 2 2 2 2 Protocadherin FAD_binding_6 PF00970.24 EFA75915.1 - 0.0061 16.9 0.0 0.046 14.1 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain EGF_Tenascin PF18720.1 EFA75915.1 - 0.38 10.8 16.9 2 8.5 5.9 2.7 2 0 0 2 2 2 0 Tenascin EGF domain Pur_ac_phosph_N PF16656.5 EFA75915.1 - 1.1 9.8 5.0 31 5.2 0.1 4.4 4 0 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain Toxin_2 PF00451.19 EFA75915.1 - 1.4 9.2 14.1 7.4 7.0 3.9 3.0 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 UQ_con PF00179.26 EFA75916.1 - 1.7e-43 147.6 0.0 3.1e-43 146.8 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFA75916.1 - 0.00018 21.2 0.0 0.00024 20.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFA75916.1 - 0.0065 16.3 0.0 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 UEV domain GATase PF00117.28 EFA75917.1 - 1.9e-11 44.1 0.0 2.7e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFA75917.1 - 3.8e-05 23.5 0.0 5.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 EFA75917.1 - 0.0018 17.9 0.0 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain 7tm_2 PF00002.24 EFA75919.1 - 0.093 12.0 14.1 0.15 11.3 14.1 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) PGG PF13962.6 EFA75919.1 - 0.11 12.3 5.3 0.093 12.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function Cpn60_TCP1 PF00118.24 EFA75920.1 - 8.9e-95 318.1 7.3 1.1e-94 317.8 7.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3915 PF13054.6 EFA75920.1 - 1.3 9.0 13.4 1.1 9.3 3.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) ketoacyl-synt PF00109.26 EFA75922.1 - 3.1e-68 230.1 0.0 4.9e-68 229.4 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA75922.1 - 1.4e-51 175.9 0.0 2e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA75922.1 - 5.4e-35 120.0 0.1 1.2e-34 118.8 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA75922.1 - 8.3e-35 120.3 0.0 1.5e-33 116.2 0.0 2.7 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 EFA75922.1 - 1.3e-21 77.1 0.0 2.5e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA75922.1 - 4.1e-16 59.4 0.0 1.3e-15 57.8 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA75922.1 - 2.6e-15 56.9 0.0 1.1e-14 55.0 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA75922.1 - 1.6e-10 40.7 0.0 2.2e-08 33.8 0.0 2.8 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EFA75922.1 - 2.8e-08 34.9 0.0 8.3e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFA75922.1 - 1.4e-07 31.5 0.1 1.2e-06 28.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N PF00107.26 EFA75922.1 - 4.1e-07 30.0 0.0 1.6e-06 28.1 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EFA75922.1 - 1.6e-05 25.5 0.0 0.00017 22.3 0.0 2.9 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA75922.1 - 4.9e-05 23.9 0.0 0.00029 21.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain adh_short_C2 PF13561.6 EFA75922.1 - 6e-05 22.7 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFA75922.1 - 0.00076 19.3 0.0 0.0038 17.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EFA75922.1 - 0.00085 19.6 0.4 0.0033 17.8 0.1 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 EFA75922.1 - 0.0029 17.4 0.0 0.0096 15.7 0.0 1.9 1 0 0 1 1 1 1 Lysine methyltransferase DUF938 PF06080.12 EFA75922.1 - 0.014 15.2 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Thiolase_N PF00108.23 EFA75922.1 - 0.021 14.2 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain ADH_N PF08240.12 EFA75922.1 - 0.026 14.4 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Abhydrolase_6 PF12697.7 EFA75923.1 - 9.4e-17 62.4 0.0 1.2e-16 62.0 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EFA75923.1 - 0.00034 20.5 0.0 0.001 18.9 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase Amidohydro_2 PF04909.14 EFA75923.1 - 0.0018 18.1 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Abhydrolase_1 PF00561.20 EFA75923.1 - 0.014 15.1 0.0 0.038 13.6 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA75923.1 - 0.026 13.8 0.0 0.36 10.1 0.0 2.5 2 1 0 2 2 2 0 Serine aminopeptidase, S33 VirJ PF06057.11 EFA75923.1 - 0.075 12.9 0.1 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) Lpp-LpqN PF10738.9 EFA75923.1 - 0.08 12.4 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Probable lipoprotein LpqN Abhydrolase_2 PF02230.16 EFA75923.1 - 0.097 12.5 0.0 1.7 8.4 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF676 PF05057.14 EFA75923.1 - 0.14 11.6 0.0 1.4 8.4 0.0 2.4 2 1 1 3 3 3 0 Putative serine esterase (DUF676) Peptidase_C1 PF00112.23 EFA75924.1 - 2e-78 263.4 2.7 6.1e-62 209.5 1.9 2.1 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA75924.1 - 7.8e-14 51.9 0.1 1.7e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA75924.1 - 8.6e-05 21.5 1.7 0.015 14.1 0.3 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Disaggr_assoc PF08480.10 EFA75924.1 - 0.014 15.3 4.5 0.92 9.4 0.3 2.5 2 0 0 2 2 2 0 Disaggregatase related Ub-Mut7C PF14451.6 EFA75924.1 - 0.021 14.6 0.1 3 7.8 0.0 2.5 2 0 0 2 2 2 0 Mut7-C ubiquitin Integrase_H2C2 PF17921.1 EFA75925.1 - 1.5e-16 60.3 0.0 2e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EFA75925.1 - 0.00023 21.3 0.0 0.00041 20.5 0.0 1.4 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH PF17917.1 EFA75926.1 - 1.5e-26 92.7 0.0 3e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA75926.1 - 1.2e-25 89.5 0.0 2.2e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EFA75926.1 - 1e-20 74.2 0.4 4.7e-11 42.6 0.0 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 EFA75926.1 - 1.8e-07 30.9 1.9 4.8e-07 29.6 1.9 1.8 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.20 EFA75926.1 - 5.1e-05 23.5 0.0 0.00016 21.9 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 EFA75926.1 - 0.00031 21.3 0.0 0.00081 20.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_2 PF13696.6 EFA75926.1 - 0.00042 20.1 2.4 0.00087 19.1 2.4 1.5 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 EFA75926.1 - 0.00051 20.6 0.0 0.0013 19.3 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RHH_3 PF12651.7 EFA75926.1 - 1.3 9.1 3.2 1 9.4 0.2 2.5 3 0 0 3 3 3 0 Ribbon-helix-helix domain Cofilin_ADF PF00241.20 EFA75927.1 - 1.1e-32 112.4 0.0 5.8e-16 58.4 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein ChpA-C PF03777.13 EFA75927.1 - 0.3 11.0 2.3 1.1 9.2 0.3 2.5 2 0 0 2 2 2 0 ChpA-C Methyltransf_16 PF10294.9 EFA75928.1 - 1.8e-07 31.0 0.0 4.4e-07 29.8 0.0 1.6 1 1 1 2 2 2 1 Lysine methyltransferase GidB PF02527.15 EFA75928.1 - 0.03 13.6 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Ras PF00071.22 EFA75929.1 - 2.5e-44 150.7 1.4 3.2e-42 143.9 1.4 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA75929.1 - 2.5e-28 98.7 1.4 1.6e-19 70.3 0.0 2.8 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA75929.1 - 2.2e-12 46.8 0.1 2.2e-08 33.7 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA75929.1 - 2.5e-05 23.9 0.0 9.3e-05 22.0 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA75929.1 - 6.6e-05 22.4 0.2 0.00029 20.3 0.2 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA75929.1 - 0.0066 16.5 2.5 0.0088 16.1 0.0 2.4 2 2 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA75929.1 - 0.0066 16.4 0.1 3.6 7.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase ThiW PF09512.10 EFA75929.1 - 0.13 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Thiamine-precursor transporter protein (ThiW) Glu_cyclase_2 PF05096.12 EFA75930.1 - 0.075 12.4 0.0 0.38 10.1 0.0 1.9 2 0 0 2 2 2 0 Glutamine cyclotransferase CENP-B_dimeris PF09026.10 EFA75931.1 - 0.0053 17.1 12.4 0.12 12.8 7.9 2.3 2 0 0 2 2 2 2 Centromere protein B dimerisation domain ELH PF02323.15 EFA75931.1 - 0.056 12.8 1.0 0.1 12.0 1.0 1.4 1 0 0 1 1 1 0 Egg-laying hormone precursor PBP1_TM PF14812.6 EFA75931.1 - 0.14 12.6 12.7 0.35 11.3 7.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 EFA75931.1 - 0.24 11.1 5.1 1.9 8.1 2.0 2.2 2 0 0 2 2 2 0 FAM176 family ABC2_membrane_3 PF12698.7 EFA75931.1 - 0.49 9.5 2.2 0.39 9.8 0.9 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF688 PF05097.12 EFA75931.1 - 0.59 9.2 6.2 1.1 8.3 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF688) NMT PF01233.19 EFA75931.1 - 5 7.0 5.3 5.5 6.8 1.2 2.2 2 0 0 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain RXT2_N PF08595.11 EFA75931.1 - 9 6.3 8.1 4.4 7.3 3.8 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF2457 PF10446.9 EFA75932.1 - 0.0053 16.0 18.4 0.0079 15.4 18.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) ComJ PF11033.8 EFA75932.1 - 0.04 13.6 2.1 0.98 9.1 0.1 2.6 3 0 0 3 3 3 0 Competence protein J (ComJ) SDA1 PF05285.12 EFA75932.1 - 0.074 12.5 13.2 0.09 12.2 13.2 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFA75932.1 - 0.14 10.4 13.0 0.17 10.2 13.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Spt5_N PF11942.8 EFA75932.1 - 0.48 11.4 19.8 0.19 12.7 14.0 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Mpp10 PF04006.12 EFA75932.1 - 1.6 7.1 23.6 2.1 6.7 23.6 1.2 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.13 EFA75932.1 - 5 5.1 13.7 7 4.6 13.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi YL1 PF05764.13 EFA75932.1 - 6.1 6.9 16.7 2.4 8.2 14.1 1.6 2 0 0 2 2 2 0 YL1 nuclear protein Ank_2 PF12796.7 EFA75933.1 - 4e-42 142.7 15.9 2.5e-10 40.8 0.1 5.9 2 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75933.1 - 3.2e-40 135.7 21.7 0.00011 22.4 0.0 12.2 2 1 10 12 12 12 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75933.1 - 2.3e-33 114.1 18.9 5.8e-05 23.6 0.1 8.9 6 1 3 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75933.1 - 1.1e-24 83.7 13.7 0.67 10.7 0.0 13.5 11 2 3 14 14 14 7 Ankyrin repeat Ank PF00023.30 EFA75933.1 - 6.1e-11 42.2 10.2 21 5.8 0.0 10.9 5 2 6 11 11 11 1 Ankyrin repeat DUF5049 PF16468.5 EFA75933.1 - 1.4e-09 37.7 5.9 6 6.8 0.0 9.7 5 4 6 11 11 11 2 Domain of unknown function (DUF5049) AhpC-TSA PF00578.21 EFA75933.1 - 0.017 15.1 0.1 4.4 7.3 0.0 3.3 3 1 1 4 4 4 0 AhpC/TSA family FBD PF08387.10 EFA75933.1 - 0.025 14.5 4.0 1.3 9.0 0.1 4.8 6 0 0 6 6 6 0 FBD PARG_cat PF05028.14 EFA75934.1 - 1.4e-124 415.8 0.0 2.3e-124 415.1 0.0 1.3 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) G8 PF10162.9 EFA75934.1 - 1.6e-28 99.2 0.0 6.7e-28 97.2 0.0 2.2 2 0 0 2 2 2 1 G8 domain Ank_2 PF12796.7 EFA75935.1 - 1.3e-58 195.6 22.0 6.5e-09 36.3 0.1 7.4 2 2 9 11 11 11 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75935.1 - 4.4e-33 112.9 16.6 0.00035 20.8 0.2 13.7 7 2 8 15 15 15 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75935.1 - 1.7e-31 108.2 6.7 3.6e-05 24.2 0.2 9.5 5 2 5 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75935.1 - 3.8e-24 82.1 4.6 0.076 13.6 0.0 14.3 13 2 2 15 15 15 4 Ankyrin repeat Ank PF00023.30 EFA75935.1 - 4.1e-12 46.0 0.4 0.17 12.4 0.0 8.0 8 1 0 8 8 8 2 Ankyrin repeat DUF5049 PF16468.5 EFA75935.1 - 3e-06 27.0 9.0 6 6.8 0.0 9.3 7 2 4 11 11 11 2 Domain of unknown function (DUF5049) DUF249 PF03158.13 EFA75935.1 - 0.025 14.3 1.3 12 5.5 0.0 4.1 3 1 0 4 4 4 0 Multigene family 530 protein MFS_1 PF07690.16 EFA75936.1 - 3e-23 82.3 37.2 5.1e-19 68.4 17.0 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA75936.1 - 4.6 6.0 36.1 34 3.1 36.1 1.9 1 1 0 1 1 1 0 Sugar (and other) transporter CD34_antigen PF06365.12 EFA75937.1 - 0.014 15.0 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4730 PF15873.5 EFA75937.1 - 0.064 13.5 5.3 0.93 9.8 5.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4730) TMEM52 PF14979.6 EFA75937.1 - 0.43 10.5 4.4 0.67 9.9 4.4 1.3 1 0 0 1 1 1 0 Transmembrane 52 zf-CDGSH PF09360.10 EFA75938.1 - 5.4e-22 77.7 6.7 7.8e-11 42.0 0.5 2.4 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type PGK PF00162.19 EFA75938.1 - 0.052 12.5 0.0 0.064 12.2 0.0 1.0 1 0 0 1 1 1 0 Phosphoglycerate kinase MSL2-CXC PF16682.5 EFA75938.1 - 0.062 13.4 5.3 1.7 8.8 0.3 2.6 2 1 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 DUF4505 PF14956.6 EFA75938.1 - 0.11 12.3 1.3 1.6 8.5 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4505) EMP70 PF02990.16 EFA75939.1 - 8.3e-198 658.2 12.4 1.2e-197 657.7 12.4 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 E2_bind PF08825.10 EFA75940.1 - 0.074 13.2 0.1 2.7 8.2 0.0 3.0 3 0 0 3 3 3 0 E2 binding domain Membr_traf_MHD PF10540.9 EFA75940.1 - 0.92 9.7 8.9 0.38 10.9 0.1 3.9 3 2 1 4 4 4 0 Munc13 (mammalian uncoordinated) homology domain Filament PF00038.21 EFA75941.1 - 0.0016 18.1 0.6 0.0025 17.4 0.6 1.3 1 0 0 1 1 1 1 Intermediate filament protein DUF16 PF01519.16 EFA75941.1 - 0.0018 18.7 2.5 0.0018 18.7 2.5 1.8 2 0 0 2 2 2 1 Protein of unknown function DUF16 Phage_Gp23 PF10669.9 EFA75941.1 - 0.0054 17.1 3.2 0.0092 16.3 3.2 1.4 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) SlyX PF04102.12 EFA75941.1 - 0.0063 17.1 1.2 0.014 16.0 1.1 1.6 2 0 0 2 2 1 1 SlyX ZapB PF06005.12 EFA75941.1 - 0.0087 16.5 3.5 0.013 15.9 2.1 2.0 1 1 1 2 2 2 1 Cell division protein ZapB DUF3584 PF12128.8 EFA75941.1 - 0.011 13.3 1.4 0.016 12.8 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2130 PF09903.9 EFA75941.1 - 0.013 14.8 3.1 0.026 13.8 3.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) Taxilin PF09728.9 EFA75941.1 - 0.015 14.5 2.3 0.02 14.1 2.3 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DUF4200 PF13863.6 EFA75941.1 - 0.018 15.4 4.4 0.033 14.6 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Jnk-SapK_ap_N PF09744.9 EFA75941.1 - 0.02 15.1 2.3 0.037 14.2 2.3 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PspA_IM30 PF04012.12 EFA75941.1 - 0.023 14.3 0.4 0.031 13.9 0.4 1.2 1 0 0 1 1 1 0 PspA/IM30 family Fib_alpha PF08702.10 EFA75941.1 - 0.025 14.8 4.4 0.025 14.8 4.4 2.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 EFA75941.1 - 0.044 13.1 1.2 0.064 12.5 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TolA_bind_tri PF16331.5 EFA75941.1 - 0.045 13.8 0.3 0.1 12.7 0.3 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation MeaB PF03308.16 EFA75941.1 - 0.05 12.6 0.2 0.12 11.4 0.1 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4446 PF14584.6 EFA75941.1 - 0.057 13.4 3.2 0.054 13.5 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Gp-FAR-1 PF05823.12 EFA75941.1 - 0.057 13.8 3.1 0.092 13.1 1.8 1.9 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) APG6_N PF17675.1 EFA75941.1 - 0.079 13.5 1.5 0.14 12.7 1.5 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Tropomyosin_1 PF12718.7 EFA75941.1 - 0.085 13.0 3.1 0.12 12.5 3.1 1.2 1 0 0 1 1 1 0 Tropomyosin like Phage_GP20 PF06810.11 EFA75941.1 - 0.093 12.5 6.1 0.24 11.2 5.9 1.8 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF1664 PF07889.12 EFA75941.1 - 0.095 12.7 2.0 0.18 11.9 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ABC_tran_Xtn PF12848.7 EFA75941.1 - 0.098 12.7 0.5 0.2 11.7 0.5 1.5 1 0 0 1 1 1 0 ABC transporter Spc29 PF17082.5 EFA75941.1 - 0.1 12.4 3.9 0.13 12.1 3.9 1.3 1 1 0 1 1 1 0 Spindle Pole Component 29 DUF948 PF06103.11 EFA75941.1 - 0.2 11.9 0.9 0.42 10.9 0.9 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CdvA PF18822.1 EFA75941.1 - 0.23 11.3 7.7 0.084 12.7 3.7 2.2 2 1 1 3 3 3 0 CdvA-like coiled-coil domain NPV_P10 PF05531.12 EFA75941.1 - 0.27 11.7 3.3 0.34 11.4 0.8 2.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 EFA75941.1 - 0.42 10.9 8.4 0.65 10.3 3.1 2.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 XhlA PF10779.9 EFA75941.1 - 0.52 10.6 6.2 0.27 11.5 3.3 2.1 1 1 0 1 1 1 0 Haemolysin XhlA HSBP1 PF06825.12 EFA75941.1 - 0.53 10.2 3.6 1.3 8.9 0.2 2.5 1 1 1 2 2 2 0 Heat shock factor binding protein 1 GrpE PF01025.19 EFA75941.1 - 0.79 9.4 6.4 1.1 8.9 0.6 2.6 2 1 1 3 3 3 0 GrpE FlaC_arch PF05377.11 EFA75941.1 - 2.5 8.6 5.1 1.1 9.7 1.2 2.5 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) FadA PF09403.10 EFA75941.1 - 3.7 8.1 8.9 0.44 11.1 2.6 2.5 2 1 0 2 2 2 0 Adhesion protein FadA He_PIG PF05345.12 EFA75942.1 - 0.025 14.8 0.1 7 6.9 0.0 2.7 2 0 0 2 2 2 0 Putative Ig domain Ank_2 PF12796.7 EFA75943.1 - 2.4e-19 69.7 4.1 8.5e-07 29.5 0.1 6.1 3 1 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75943.1 - 7e-16 58.4 5.3 0.00096 19.7 0.0 8.4 5 3 1 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA75943.1 - 1e-12 48.0 8.3 0.0081 16.5 0.0 8.9 5 4 5 10 10 10 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75943.1 - 1.1e-09 37.8 3.5 0.53 11.0 0.0 8.9 9 1 1 10 10 10 1 Ankyrin repeat DUF3447 PF11929.8 EFA75943.1 - 0.011 15.7 9.6 0.025 14.5 0.1 4.8 3 1 2 5 5 5 0 Domain of unknown function (DUF3447) Tn7_Tnp_TnsA_C PF08721.11 EFA75943.1 - 0.062 13.9 0.8 14 6.4 0.1 3.4 3 0 0 3 3 3 0 TnsA endonuclease C terminal Ank PF00023.30 EFA75943.1 - 0.075 13.5 3.1 2.4e+02 2.5 0.0 5.8 6 1 0 6 6 6 0 Ankyrin repeat Pkinase_Tyr PF07714.17 EFA75945.1 - 7.7e-52 176.1 0.0 1.4e-51 175.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA75945.1 - 5.6e-46 157.1 0.0 5.6e-46 157.1 0.0 1.9 2 0 0 2 2 1 1 Protein kinase domain COR PF16095.5 EFA75945.1 - 1.4e-37 129.4 0.2 2e-26 93.0 0.0 2.9 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain Roc PF08477.13 EFA75945.1 - 1.5e-22 80.1 0.9 8.1e-17 61.6 0.0 3.0 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 EFA75945.1 - 4.8e-22 77.5 40.9 1.5e-11 43.9 2.9 7.6 6 2 3 9 9 9 4 Leucine rich repeat LRR_4 PF12799.7 EFA75945.1 - 5e-17 61.7 38.3 1.1e-05 25.6 1.2 8.0 5 2 2 7 7 7 5 Leucine Rich repeats (2 copies) RhoGEF PF00621.20 EFA75945.1 - 1.2e-14 55.0 7.1 1.1e-10 42.1 5.0 3.3 2 0 0 2 2 2 2 RhoGEF domain Ras PF00071.22 EFA75945.1 - 1.4e-10 41.0 0.0 2e-08 34.0 0.0 2.5 1 1 0 1 1 1 1 Ras family LRR_6 PF13516.6 EFA75945.1 - 2.7e-07 30.1 28.2 0.27 11.4 0.2 9.9 9 0 0 9 9 9 2 Leucine Rich repeat LRR_1 PF00560.33 EFA75945.1 - 0.00039 20.6 19.0 4.1 8.3 0.0 9.5 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_9 PF14580.6 EFA75945.1 - 0.0019 17.7 1.2 0.0019 17.7 1.2 3.8 2 1 1 3 3 3 2 Leucine-rich repeat Clathrin PF00637.20 EFA75946.1 - 4.4e-22 78.5 26.6 1.2e-15 57.6 9.0 3.9 2 2 1 3 3 3 2 Region in Clathrin and VPS VPS11_C PF12451.8 EFA75946.1 - 3.3e-14 52.8 0.8 3.3e-14 52.8 0.8 2.5 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EFA75946.1 - 3.6e-06 26.9 8.1 7.7e-06 25.8 8.1 1.6 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EFA75946.1 - 0.0013 18.6 9.1 0.0028 17.5 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFA75946.1 - 0.0069 16.4 2.3 1.3 9.1 1.1 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFA75946.1 - 0.0099 16.2 9.3 0.024 15.0 9.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFA75946.1 - 0.028 14.7 7.8 0.076 13.3 7.8 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFA75946.1 - 0.03 14.3 8.0 0.072 13.1 8.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain CRR7 PF12095.8 EFA75946.1 - 0.36 11.3 4.2 12 6.5 1.0 3.6 3 0 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 zf-RING_UBOX PF13445.6 EFA75946.1 - 1.5 8.9 10.3 3.8 7.6 10.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Fzo_mitofusin PF04799.13 EFA75946.1 - 2.3 7.8 7.6 1.5 8.4 3.0 2.5 2 0 0 2 2 2 0 fzo-like conserved region Prefoldin_2 PF01920.20 EFA75946.1 - 2.3 8.2 12.4 1.4 8.9 4.6 3.4 3 1 0 3 3 3 0 Prefoldin subunit FYVE_2 PF02318.16 EFA75946.1 - 2.4 8.4 6.5 1.5 9.1 3.6 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger zf-C3HC4 PF00097.25 EFA75946.1 - 3 7.8 8.7 7.7 6.5 8.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 EFA75946.1 - 4.1 7.9 10.3 0.4 11.1 1.9 3.4 3 1 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 VWA_2 PF13519.6 EFA75947.1 - 1.5e-05 25.6 0.1 0.0011 19.6 0.1 3.2 1 1 0 1 1 1 1 von Willebrand factor type A domain Sec23_trunk PF04811.15 EFA75947.1 - 0.00025 20.7 0.1 0.0038 16.8 0.1 2.8 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain DUF3800 PF12686.7 EFA75947.1 - 0.00072 20.2 0.0 0.09 13.4 0.1 3.2 2 2 0 2 2 2 1 Protein of unknown function (DUF3800) Sec23_BS PF08033.12 EFA75947.1 - 0.0012 19.6 0.4 0.0064 17.2 0.1 2.5 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain DUF4660 PF15559.6 EFA75947.1 - 0.095 13.0 0.2 0.095 13.0 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4660) VWA_CoxE PF05762.14 EFA75947.1 - 0.23 10.8 0.6 2 7.7 0.0 2.4 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein YafO_toxin PF13957.6 EFA75949.1 - 0.088 12.9 0.1 0.097 12.7 0.1 1.1 1 0 0 1 1 1 0 Toxin YafO, type II toxin-antitoxin system EXS PF03124.14 EFA75950.1 - 9.8e-63 212.5 40.2 9.8e-63 212.5 40.2 1.5 2 0 0 2 2 2 1 EXS family SPX PF03105.19 EFA75950.1 - 6.5e-12 46.1 18.2 2.7e-10 40.7 8.8 2.2 1 1 0 2 2 2 2 SPX domain DUF1996 PF09362.10 EFA75951.1 - 3.3e-36 125.5 0.7 3.3e-36 125.5 0.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1996) Ank_2 PF12796.7 EFA75951.1 - 1.3e-11 45.0 6.5 0.00038 21.0 0.4 6.0 4 1 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75951.1 - 5.6e-07 29.7 5.0 9.3 6.7 0.0 8.2 7 2 3 10 10 10 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA75951.1 - 2e-05 25.0 4.2 0.82 10.3 0.0 6.6 7 2 1 8 8 8 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75951.1 - 7.9e-05 22.8 2.8 5.9 7.8 0.1 7.3 7 0 0 7 7 7 1 Ankyrin repeat FancD2 PF14631.6 EFA75952.1 - 8e-115 384.8 36.7 2.1e-95 320.5 13.5 7.2 4 2 4 8 8 8 4 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 EFA75952.1 - 0.0036 17.6 6.8 0.016 15.5 0.2 4.7 4 0 0 4 4 4 1 FANCI solenoid 2 CSTF2_hinge PF14327.6 EFA75952.1 - 0.41 11.1 4.2 27 5.3 0.0 4.2 4 0 0 4 4 4 0 Hinge domain of cleavage stimulation factor subunit 2 Orf78 PF06024.12 EFA75953.1 - 0.25 11.6 0.1 0.25 11.6 0.1 2.3 3 0 0 3 3 3 0 Orf78 (ac78) Aldedh PF00171.22 EFA75954.1 - 8e-180 598.3 0.0 9e-180 598.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MACPF PF01823.19 EFA75955.1 - 3.2e-20 73.1 2.9 1e-19 71.5 2.9 1.9 1 0 0 1 1 1 1 MAC/Perforin domain MACPF PF01823.19 EFA75956.1 - 6.6e-23 81.9 4.2 1.5e-22 80.7 4.2 1.6 1 0 0 1 1 1 1 MAC/Perforin domain DUF4215 PF13948.6 EFA75956.1 - 0.016 15.6 1.0 0.016 15.6 1.0 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4215) GRAM PF02893.20 EFA75956.1 - 0.27 11.1 2.6 0.67 9.9 0.3 2.8 3 0 0 3 3 3 0 GRAM domain Rap_GAP PF02145.15 EFA75957.1 - 2.9e-63 212.8 0.4 2.9e-63 212.8 0.4 2.1 3 0 0 3 3 3 1 Rap/ran-GAP TFIIF_alpha PF05793.12 EFA75957.1 - 0.005 15.5 19.5 0.0085 14.7 12.2 2.3 2 0 0 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2052 PF09747.9 EFA75957.1 - 0.032 14.4 13.9 0.031 14.4 9.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF853 PF05872.12 EFA75957.1 - 0.038 12.6 3.4 0.064 11.8 3.4 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) GIDA_assoc PF13932.6 EFA75957.1 - 0.068 13.4 6.4 0.18 11.9 6.4 1.8 1 0 0 1 1 1 0 GidA associated domain DUF3987 PF13148.6 EFA75957.1 - 0.17 10.9 15.4 0.25 10.3 15.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) EOS1 PF12326.8 EFA75957.1 - 0.59 10.0 2.3 1.6 8.7 2.3 1.7 1 0 0 1 1 1 0 N-glycosylation protein PTPRCAP PF15713.5 EFA75957.1 - 0.65 10.3 15.2 0.36 11.1 11.1 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Paramyxo_ncap PF00973.19 EFA75957.1 - 0.99 8.2 7.4 1.7 7.5 7.4 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4407 PF14362.6 EFA75957.1 - 1 8.7 3.6 1.5 8.1 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PA26 PF04636.13 EFA75957.1 - 1.1 8.0 5.6 2.1 7.2 5.6 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4637 PF15470.6 EFA75957.1 - 1.4 8.6 18.0 4.1 7.1 15.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) AAA_23 PF13476.6 EFA75957.1 - 1.8 9.0 23.7 0.15 12.6 15.3 2.5 2 0 0 2 2 2 0 AAA domain DUF4666 PF15697.5 EFA75957.1 - 3 8.6 11.3 3.5 8.3 8.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) NARP1 PF12569.8 EFA75957.1 - 7 5.4 19.1 16 4.3 19.1 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Serinc PF03348.15 EFA75957.1 - 9.5 5.0 5.5 20 3.9 5.5 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ribosomal_S8 PF00410.19 EFA75958.1 - 4.5e-14 52.5 0.0 1.4e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Ribosomal protein S8 RXT2_N PF08595.11 EFA75958.1 - 0.02 15.0 0.8 0.02 15.0 0.8 2.0 3 0 0 3 3 3 0 RXT2-like, N-terminal BBS1 PF14779.6 EFA75958.1 - 0.095 12.1 0.0 7.1 6.0 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 DARPP-32 PF05395.12 EFA75958.1 - 0.14 12.4 3.0 0.12 12.6 0.4 2.0 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 CENP-B_dimeris PF09026.10 EFA75958.1 - 0.55 10.7 5.8 0.97 9.9 3.6 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain G-alpha PF00503.20 EFA75959.1 - 1.2e-97 327.3 8.5 1.5e-97 327.0 8.5 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA75959.1 - 1.5e-15 57.1 2.8 6.2e-12 45.3 0.3 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA75959.1 - 8.6e-06 25.3 2.3 0.00049 19.5 0.2 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA75959.1 - 0.00035 20.8 0.9 0.48 10.7 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA75959.1 - 0.0007 19.7 0.2 0.04 14.0 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA75959.1 - 0.0014 18.1 0.8 0.12 11.8 0.0 3.2 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFA75959.1 - 0.0019 17.8 0.7 0.052 13.1 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.22 EFA75959.1 - 0.0086 15.7 2.1 0.17 11.4 0.2 2.4 2 0 0 2 2 2 1 Ras family AAA_29 PF13555.6 EFA75959.1 - 0.076 12.8 0.2 0.32 10.8 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain Fes1 PF08609.10 EFA75959.1 - 0.11 13.3 0.1 10 7.1 0.0 2.5 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 PAT1 PF09770.9 EFA75960.1 - 0.00035 19.0 0.0 0.00035 19.0 0.0 4.3 2 2 2 4 4 4 2 Topoisomerase II-associated protein PAT1 TIG PF01833.24 EFA75962.1 - 1e-57 192.1 180.4 1.4e-09 37.9 5.6 16.9 14 2 2 16 16 16 14 IPT/TIG domain EGF_2 PF07974.13 EFA75962.1 - 0.061 13.7 14.7 0.17 12.3 14.7 1.8 1 0 0 1 1 1 0 EGF-like domain DUF3211 PF11485.8 EFA75962.1 - 0.09 13.0 0.1 0.54 10.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3211) hEGF PF12661.7 EFA75962.1 - 0.31 11.7 8.8 1.4 9.7 8.8 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF TIG PF01833.24 EFA75963.1 - 1.9e-68 226.6 168.5 3.6e-10 39.8 4.7 17.5 12 2 5 17 17 17 16 IPT/TIG domain Toxin_2 PF00451.19 EFA75963.1 - 0.86 10.0 6.5 1.9 8.9 6.5 1.6 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 DBB PF14545.6 EFA75963.1 - 2.8 7.8 6.1 2.8 7.9 0.2 3.9 4 0 0 4 4 4 0 Dof, BCAP, and BANK (DBB) motif, AATase PF07247.12 EFA75964.1 - 7.6e-19 67.6 17.0 4.9e-18 65.0 6.2 2.8 2 1 0 2 2 2 2 Alcohol acetyltransferase Condensation PF00668.20 EFA75964.1 - 1.6e-16 60.0 0.0 1.6e-08 33.7 0.1 4.9 4 1 0 4 4 4 4 Condensation domain WES_acyltransf PF03007.16 EFA75964.1 - 0.0048 16.7 0.0 0.16 11.7 0.0 2.2 2 0 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF4208 PF13907.6 EFA75964.1 - 0.025 15.0 0.0 0.07 13.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) EF-hand_8 PF13833.6 EFA75965.1 - 0.00036 20.3 0.0 0.0007 19.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EFA75965.1 - 0.00043 20.7 0.6 0.00087 19.7 0.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFA75965.1 - 0.0016 17.8 0.1 0.0033 16.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EFA75965.1 - 0.0018 18.1 0.1 0.004 17.0 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain Coilin_N PF15862.5 EFA75965.1 - 0.014 15.2 1.8 0.014 15.2 1.8 3.9 3 1 0 3 3 3 0 Coilin N-terminus Gaa1 PF04114.14 EFA75965.1 - 3.3 6.6 15.2 2.6 6.9 3.1 2.2 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component EB PF01683.18 EFA75966.1 - 0.0043 17.3 2.9 0.0043 17.3 2.9 7.7 2 2 3 5 5 5 2 EB module Dickkopf_N PF04706.12 EFA75966.1 - 0.0057 17.1 11.2 0.0057 17.1 11.2 6.6 3 3 3 6 6 6 3 Dickkopf N-terminal cysteine-rich region SapB_2 PF03489.17 EFA75967.1 - 9e-30 102.5 18.0 3.3e-11 43.1 0.4 4.5 5 0 0 5 5 5 3 Saposin-like type B, region 2 SapB_1 PF05184.15 EFA75967.1 - 1.3e-27 95.4 9.6 2.3e-09 37.1 0.1 4.0 3 0 0 3 3 3 3 Saposin-like type B, region 1 NTS_2 PF15448.6 EFA75967.1 - 0.074 13.5 1.2 1.1e+02 3.3 0.0 4.0 3 1 1 4 4 4 0 N-terminal segments of P. falciparum erythrocyte membrane protein amfpi-1 PF12190.8 EFA75967.1 - 6.8 7.4 8.3 2.6 8.7 0.3 3.5 2 1 2 4 4 4 0 Fungal protease inhibitor PseudoU_synth_1 PF01416.20 EFA75968.1 - 9.1e-15 55.0 0.0 1.3e-10 41.6 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 EFA75968.1 - 0.019 14.8 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) PI3_PI4_kinase PF00454.27 EFA75969.1 - 0.021 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFA75970.1 - 3e-35 121.3 0.7 6.7e-35 120.2 0.7 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA75970.1 - 3.8e-24 85.9 0.6 4.8e-22 79.0 0.2 3.1 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PH PF00169.29 EFA75970.1 - 2.6e-10 40.7 1.9 3.6e-10 40.3 0.1 2.3 2 0 0 2 2 2 1 PH domain DUF4135 PF13575.6 EFA75970.1 - 0.0057 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PI3K_rbd PF00794.18 EFA75970.1 - 0.026 14.7 0.1 0.18 12.0 0.1 2.5 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain Robl_LC7 PF03259.17 EFA75971.1 - 7.2e-07 28.9 0.0 2.7e-06 27.1 0.0 2.0 2 1 0 2 2 2 1 Roadblock/LC7 domain NUDIX PF00293.28 EFA75971.1 - 4.2e-06 26.8 0.0 6.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain RRF PF01765.19 EFA75971.1 - 0.032 14.2 2.8 0.043 13.8 1.6 1.8 2 0 0 2 2 2 0 Ribosome recycling factor AAA_19 PF13245.6 EFA75972.1 - 0.1 12.9 0.1 11 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain LRR_9 PF14580.6 EFA75972.1 - 0.1 12.1 6.2 2.3 7.7 0.8 2.9 2 0 0 2 2 2 0 Leucine-rich repeat BtrH_N PF14399.6 EFA75972.1 - 0.16 12.2 0.1 0.38 11.0 0.1 1.6 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal DNase_II PF03265.15 EFA75973.1 - 2.3e-28 99.5 4.7 1.4e-16 60.7 7.4 3.4 2 0 0 2 2 2 2 Deoxyribonuclease II TIG PF01833.24 EFA75973.1 - 4.9e-13 49.0 54.7 2.2e-08 34.0 0.7 11.5 10 1 1 11 11 11 4 IPT/TIG domain SdrD_B PF17210.3 EFA75973.1 - 2.2e-05 24.7 0.5 0.00014 22.1 0.5 2.5 1 0 0 1 1 1 1 SdrD B-like domain DUF4624 PF15417.6 EFA75973.1 - 0.0096 15.7 0.2 0.14 12.0 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4624) TIG PF01833.24 EFA75974.1 - 4.2e-90 296.0 141.4 1.3e-14 54.0 1.5 19.8 22 1 0 22 22 18 12 IPT/TIG domain SdrD_B PF17210.3 EFA75974.1 - 5.2e-11 42.8 4.3 3.5e-08 33.6 0.1 7.0 7 0 0 7 7 7 2 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA75974.1 - 4.4e-08 33.3 0.2 2.3e-05 24.6 0.0 5.6 5 0 0 5 5 3 2 Carboxypeptidase regulatory-like domain CBM49 PF09478.10 EFA75974.1 - 8.7e-07 29.2 4.2 8.7e-07 29.2 4.2 5.4 3 0 0 3 3 3 1 Carbohydrate binding domain CBM49 DUF2012 PF09430.10 EFA75974.1 - 7.2e-05 22.9 0.7 0.014 15.5 0.2 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 EFA75974.1 - 0.0031 17.5 8.3 0.68 10.0 0.1 4.8 4 0 0 4 4 4 2 CarboxypepD_reg-like domain EGF_2 PF07974.13 EFA75974.1 - 0.026 14.9 10.6 0.061 13.7 10.6 1.6 1 0 0 1 1 1 0 EGF-like domain SKG6 PF08693.10 EFA75974.1 - 0.029 13.8 1.4 0.08 12.4 1.4 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Y_Y_Y PF07495.13 EFA75974.1 - 0.033 14.2 10.5 0.087 12.8 0.2 4.2 3 0 0 3 3 2 0 Y_Y_Y domain EGF_Tenascin PF18720.1 EFA75974.1 - 0.4 10.8 6.2 1.5 8.9 6.2 2.0 1 0 0 1 1 1 0 Tenascin EGF domain AF-4 PF05110.13 EFA75974.1 - 0.41 8.7 15.3 0.79 7.7 15.3 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Syndecan PF01034.20 EFA75974.1 - 0.69 9.9 2.5 1.7 8.6 2.5 1.6 1 0 0 1 1 1 0 Syndecan domain adh_short PF00106.25 EFA75975.1 - 3.9e-44 150.4 0.0 6.1e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA75975.1 - 3.8e-31 108.5 0.0 6.6e-31 107.7 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA75975.1 - 5.6e-12 45.9 0.0 9.9e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFA75975.1 - 9.8e-05 22.3 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFA75975.1 - 0.00016 21.2 0.2 0.0013 18.2 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EFA75975.1 - 0.002 17.6 0.0 0.0027 17.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFA75975.1 - 0.042 13.3 0.1 1.5 8.1 0.1 2.1 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFA75975.1 - 0.083 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain ADH_zinc_N PF00107.26 EFA75975.1 - 0.13 12.2 0.0 0.44 10.5 0.0 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase adh_short PF00106.25 EFA75976.1 - 1e-44 152.4 0.1 1.2e-44 152.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA75976.1 - 1.9e-33 116.0 0.0 2.2e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA75976.1 - 2.7e-11 43.7 0.0 3.9e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA75976.1 - 0.0012 18.4 0.7 0.0038 16.7 0.7 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA75976.1 - 0.0052 16.7 0.0 0.0064 16.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EFA75976.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 EFA75976.1 - 0.029 14.3 0.1 0.12 12.4 0.0 1.9 1 1 1 2 2 2 0 Zinc-binding dehydrogenase TIG PF01833.24 EFA75977.1 - 9.4e-64 211.5 81.1 3.5e-13 49.4 0.0 13.2 14 0 0 14 14 14 10 IPT/TIG domain DNase_II PF03265.15 EFA75977.1 - 4.1e-20 72.3 11.6 4.7e-20 72.1 2.2 3.6 3 1 1 4 4 4 2 Deoxyribonuclease II AmiS_UreI PF02293.15 EFA75977.1 - 0.2 11.7 0.6 0.44 10.5 0.6 1.5 1 0 0 1 1 1 0 AmiS/UreI family transporter AAA PF00004.29 EFA75978.1 - 4.2e-82 273.1 1.9 1.7e-42 144.9 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA75978.1 - 1.8e-27 94.9 0.2 1.1e-16 60.4 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFA75978.1 - 4e-12 46.8 0.1 0.00016 22.1 0.0 3.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 EFA75978.1 - 1.8e-11 44.5 0.1 1.1e-05 25.6 0.0 2.9 3 1 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFA75978.1 - 8.3e-09 35.6 2.4 0.0022 18.0 0.2 4.4 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFA75978.1 - 1.5e-08 34.6 0.0 9.6e-05 22.2 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EFA75978.1 - 2.1e-07 30.4 0.0 0.0055 15.9 0.0 3.5 3 1 1 4 4 4 2 Protein of unknown function (DUF815) AAA_11 PF13086.6 EFA75978.1 - 3.1e-07 30.5 0.9 0.34 10.6 0.0 3.4 3 0 0 3 3 3 3 AAA domain AAA_22 PF13401.6 EFA75978.1 - 2e-06 28.1 0.5 0.4 10.9 0.0 3.7 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 EFA75978.1 - 5.5e-06 25.8 0.1 0.0089 15.3 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain NACHT PF05729.12 EFA75978.1 - 5.9e-06 26.3 0.3 0.57 10.1 0.0 4.1 3 1 0 4 4 4 1 NACHT domain AAA_14 PF13173.6 EFA75978.1 - 9.8e-06 25.6 0.2 0.19 11.8 0.0 3.2 3 0 0 3 3 2 2 AAA domain Bac_DnaA PF00308.18 EFA75978.1 - 1.2e-05 25.3 0.0 0.077 12.8 0.0 3.0 2 1 0 2 2 2 2 Bacterial dnaA protein TsaE PF02367.17 EFA75978.1 - 3.2e-05 23.9 0.0 0.19 11.8 0.0 2.9 2 1 1 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EFA75978.1 - 5e-05 23.5 0.3 0.19 11.9 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_3 PF07726.11 EFA75978.1 - 6.9e-05 22.7 0.0 0.45 10.4 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFA75978.1 - 0.00014 21.8 4.2 0.00073 19.5 0.0 3.4 4 0 0 4 4 4 1 Rad17 P-loop domain RNA_helicase PF00910.22 EFA75978.1 - 0.00015 22.1 1.6 0.68 10.3 0.0 3.8 3 0 0 3 3 3 1 RNA helicase Viral_helicase1 PF01443.18 EFA75978.1 - 0.00025 20.9 0.0 0.59 9.8 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EFA75978.1 - 0.00045 20.7 2.5 0.95 10.0 0.0 3.7 3 1 0 3 3 3 1 ABC transporter ATPase_2 PF01637.18 EFA75978.1 - 0.00054 19.9 0.1 0.5 10.2 0.0 3.5 2 2 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFA75978.1 - 0.00054 19.5 0.0 0.87 9.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 EFA75978.1 - 0.00097 18.9 0.0 0.53 10.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFA75978.1 - 0.0012 18.6 0.0 0.73 9.5 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein NTPase_1 PF03266.15 EFA75978.1 - 0.0015 18.5 0.5 0.82 9.6 0.0 3.3 2 1 1 3 3 3 1 NTPase AAA_18 PF13238.6 EFA75978.1 - 0.0032 18.0 1.2 2.1 8.9 0.0 3.5 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 EFA75978.1 - 0.0032 16.8 0.0 0.47 9.7 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.6 EFA75978.1 - 0.0033 17.8 1.0 0.76 10.1 0.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA75978.1 - 0.0036 17.0 0.0 0.58 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFA75978.1 - 0.014 14.8 0.1 4.6 6.6 0.0 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EFA75978.1 - 0.016 15.0 0.0 7 6.5 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain MCM PF00493.23 EFA75978.1 - 0.018 14.2 0.0 3.5 6.7 0.0 2.4 2 0 0 2 2 2 0 MCM P-loop domain AAA_28 PF13521.6 EFA75978.1 - 0.026 14.8 0.2 2 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFA75978.1 - 0.027 14.2 0.1 2.8 7.6 0.0 3.6 2 2 0 2 2 2 0 Sigma-54 interaction domain NB-ARC PF00931.22 EFA75978.1 - 0.053 12.7 2.3 2.9 7.0 0.0 3.4 4 0 0 4 4 3 0 NB-ARC domain AAA_25 PF13481.6 EFA75978.1 - 0.059 13.0 0.8 11 5.5 0.1 3.5 2 2 1 3 3 3 0 AAA domain Zot PF05707.12 EFA75978.1 - 0.08 12.6 0.0 1.1 8.9 0.0 2.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_17 PF13207.6 EFA75978.1 - 0.29 11.6 3.9 1.5 9.2 0.0 3.2 4 0 0 4 4 2 0 AAA domain Hydin_ADK PF17213.3 EFA75978.1 - 0.92 9.8 3.2 3.1 8.0 0.1 2.7 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain ResIII PF04851.15 EFA75978.1 - 4.3 7.3 0.0 4.3 7.3 0.0 3.0 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit Ribosomal_L27 PF01016.19 EFA75979.1 - 8.1e-36 121.9 1.3 1.3e-35 121.2 0.3 1.9 2 0 0 2 2 2 1 Ribosomal L27 protein DZR PF12773.7 EFA75979.1 - 0.024 14.6 3.0 0.057 13.5 1.0 2.2 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EFA75979.1 - 0.056 13.4 2.3 0.26 11.3 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbons NOB1_Zn_bind PF08772.11 EFA75979.1 - 0.068 13.3 1.2 0.25 11.6 1.2 2.0 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zf-CHY PF05495.12 EFA75979.1 - 0.11 13.0 2.8 4.8 7.7 0.5 2.4 2 0 0 2 2 2 0 CHY zinc finger zinc_ribbon_15 PF17032.5 EFA75979.1 - 0.35 11.7 5.8 0.67 10.8 2.4 2.3 2 0 0 2 2 2 0 zinc-ribbon family zf-ribbon_3 PF13248.6 EFA75979.1 - 3.4 7.2 5.4 9.5 5.8 5.4 1.8 1 1 0 1 1 1 0 zinc-ribbon domain EGF_2 PF07974.13 EFA75980.1 - 0.026 14.9 14.0 0.051 13.9 14.0 1.5 1 0 0 1 1 1 0 EGF-like domain FAM176 PF14851.6 EFA75980.1 - 0.076 12.7 0.1 0.37 10.4 0.1 1.9 2 0 0 2 2 2 0 FAM176 family hEGF PF12661.7 EFA75980.1 - 1.8 9.3 11.7 5 7.9 11.7 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Toxin_5 PF05294.13 EFA75980.1 - 1.8 9.0 10.1 0.098 13.1 4.4 1.9 2 0 0 2 2 2 0 Scorpion short toxin Cyclin_N PF00134.23 EFA75981.1 - 0.00011 21.9 1.0 0.00011 21.9 1.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain DUF1908 PF08926.11 EFA75981.1 - 0.0011 18.2 1.0 0.0011 18.2 1.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1908) DUF4805 PF16063.5 EFA75981.1 - 0.0063 15.9 2.9 0.01 15.2 2.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4805) SUIM_assoc PF16619.5 EFA75981.1 - 0.035 14.2 11.9 0.17 12.0 3.3 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 PAP1 PF08601.10 EFA75981.1 - 0.19 11.4 13.6 0.29 10.8 13.6 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Apc15p PF05841.11 EFA75981.1 - 2.1 9.2 11.1 0.21 12.4 5.5 2.0 2 0 0 2 2 2 0 Apc15p protein GATA PF00320.27 EFA75982.1 - 2.5e-16 59.0 4.3 5e-16 58.0 4.3 1.5 1 0 0 1 1 1 1 GATA zinc finger AT_hook PF02178.19 EFA75982.1 - 0.15 12.0 2.8 0.38 10.8 2.8 1.8 1 0 0 1 1 1 0 AT hook motif MCM PF00493.23 EFA75984.1 - 1.2e-100 335.2 0.0 1.8e-100 334.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFA75984.1 - 5.7e-37 126.4 0.2 1.1e-36 125.5 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFA75984.1 - 2.3e-25 88.8 0.0 4.9e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFA75984.1 - 3.1e-10 40.6 1.4 8e-10 39.2 1.4 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFA75984.1 - 6e-07 29.0 0.2 0.00047 19.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA75984.1 - 6.2e-06 26.2 0.0 2.5e-05 24.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFA75984.1 - 0.00098 19.0 0.0 0.022 14.6 0.0 2.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFA75984.1 - 0.1 12.3 0.0 9.3 5.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain GOLD_2 PF13897.6 EFA75984.1 - 2.6 8.6 7.6 0.26 11.8 0.4 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Ank_2 PF12796.7 EFA75986.1 - 3.8e-15 56.3 7.8 0.083 13.5 0.2 7.6 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA75986.1 - 8.7e-06 26.2 10.6 3.3 8.4 0.1 8.8 6 3 2 8 8 8 1 Ankyrin repeats (many copies) TPR_19 PF14559.6 EFA75986.1 - 9.4e-05 22.8 0.0 0.053 14.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 EFA75986.1 - 0.00037 20.3 0.0 0.00098 18.9 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 EFA75986.1 - 0.0099 16.2 0.1 1.8 8.9 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Ank_3 PF13606.6 EFA75986.1 - 0.011 16.1 5.5 4.1e+02 2.2 0.0 9.1 11 0 0 11 11 9 0 Ankyrin repeat TPR_6 PF13174.6 EFA75986.1 - 0.089 13.5 0.0 51 4.8 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA75986.1 - 0.099 12.9 0.0 11 6.6 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Myb_DNA-bind_5 PF13873.6 EFA75986.1 - 0.11 12.6 0.0 0.31 11.1 0.0 1.8 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF1843 PF08898.10 EFA75986.1 - 0.13 12.8 0.1 0.44 11.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) UPF0147 PF03685.13 EFA75986.1 - 0.14 12.3 0.4 28 4.9 0.0 3.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0147) COesterase PF00135.28 EFA75987.1 - 1.3e-118 397.2 0.0 1.8e-118 396.6 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA75987.1 - 6.5e-08 32.7 0.0 1.4e-07 31.6 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA75987.1 - 0.075 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ank_4 PF13637.6 EFA75988.1 - 9.4e-15 54.8 8.7 0.00011 22.7 0.1 8.0 4 1 3 7 7 7 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA75988.1 - 1.6e-11 44.6 1.4 0.021 15.4 0.0 5.1 1 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA75988.1 - 9e-11 41.8 6.7 0.09 13.1 0.0 6.8 6 2 2 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA75988.1 - 2.9e-06 27.2 9.4 6.3 7.7 0.1 8.8 9 1 1 10 10 10 2 Ankyrin repeat Lipocalin_2 PF08212.12 EFA75988.1 - 0.014 15.3 0.0 0.39 10.6 0.1 2.5 2 0 0 2 2 2 0 Lipocalin-like domain SET PF00856.28 EFA75989.1 - 0.052 13.9 1.1 0.1 13.0 0.1 1.8 1 1 0 2 2 2 0 SET domain HTH_29 PF13551.6 EFA75989.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.6 EFA75989.1 - 0.19 11.6 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain DUF2457 PF10446.9 EFA75989.1 - 7.1 5.6 21.9 0.052 12.7 11.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) CAF1A PF12253.8 EFA75989.1 - 7.9 6.7 14.5 0.54 10.5 8.0 2.3 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A DUF4637 PF15470.6 EFA75989.1 - 8.1 6.1 8.9 17 5.1 8.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF659 PF04937.15 EFA75990.1 - 0.0019 18.1 3.5 0.0019 18.1 3.5 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF 659) zf-C2H2_12 PF18658.1 EFA75990.1 - 0.0025 17.3 0.1 0.0055 16.2 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger C2H2-type DHR-2 PF06920.13 EFA75991.1 - 3.8e-172 573.6 6.5 3.8e-172 573.6 6.5 1.6 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EFA75991.1 - 3.4e-48 164.0 5.0 3.9e-46 157.3 2.9 2.8 2 0 0 2 2 2 2 C2 domain in Dock180 and Zizimin proteins CPSase_L_D2 PF02786.17 EFA75992.1 - 6.1e-76 254.6 0.1 1.1e-75 253.8 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFA75992.1 - 1.3e-45 154.4 0.1 2.8e-45 153.4 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFA75992.1 - 3.1e-28 98.0 0.0 8.8e-28 96.6 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFA75992.1 - 6.7e-16 57.9 0.2 1.6e-15 56.7 0.2 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme PCC_BT PF18140.1 EFA75992.1 - 7.7e-11 42.4 0.1 2.2e-10 40.9 0.1 1.8 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Dala_Dala_lig_C PF07478.13 EFA75992.1 - 2.1e-08 33.9 0.0 1.3e-07 31.4 0.0 2.1 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFA75992.1 - 3.2e-08 33.3 0.0 6.5e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EFA75992.1 - 1.6e-06 28.3 0.0 3.7e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 EFA75992.1 - 0.0042 16.6 0.0 0.0084 15.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EFA75992.1 - 0.0047 16.2 0.0 0.024 13.9 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Biotin_lipoyl_2 PF13533.6 EFA75992.1 - 0.073 12.9 0.0 0.33 10.8 0.0 2.0 1 1 1 2 2 2 0 Biotin-lipoyl like Radical_SAM PF04055.21 EFA75993.1 - 9.9e-12 45.6 0.0 7.4e-11 42.7 0.0 2.2 2 0 0 2 2 2 1 Radical SAM superfamily HemN_C PF06969.16 EFA75993.1 - 1.5e-10 40.9 0.3 6.8e-10 38.9 0.0 2.2 2 0 0 2 2 2 1 HemN C-terminal domain Pro_isomerase PF00160.21 EFA75994.1 - 2e-47 161.4 2.0 2.2e-47 161.2 2.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M56 PF05569.11 EFA75995.1 - 0.028 13.6 4.3 0.045 12.9 0.9 2.0 1 1 1 2 2 2 0 BlaR1 peptidase M56 Phlebovirus_G1 PF07243.11 EFA75995.1 - 0.32 9.3 3.3 0.35 9.2 3.3 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 Prefoldin PF02996.17 EFA75996.1 - 0.0033 17.3 4.1 1.2 9.0 0.1 3.4 2 1 1 4 4 4 1 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 EFA75996.1 - 0.024 14.9 1.5 0.062 13.5 0.2 2.1 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF3385 PF11865.8 EFA75996.1 - 0.064 13.2 4.3 0.12 12.3 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) CLZ PF16526.5 EFA75996.1 - 0.12 12.8 0.2 0.55 10.6 0.0 2.2 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RPW8 PF05659.11 EFA75996.1 - 0.8 9.4 6.6 6.2 6.5 0.1 3.2 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 CCAP PF11105.8 EFA75996.1 - 1.8 8.5 6.2 0.33 10.9 0.8 2.1 1 1 0 2 2 2 0 Arthropod cardioacceleratory peptide 2a DUF4200 PF13863.6 EFA75996.1 - 2.4 8.6 8.2 1.2 9.5 1.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF3450 PF11932.8 EFA75996.1 - 4.5 6.5 6.4 0.94 8.7 2.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4192 PF13830.6 EFA75997.1 - 0.044 13.9 1.3 0.055 13.5 1.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) DHR10 PF18595.1 EFA75997.1 - 0.051 13.6 12.5 0.075 13.1 12.5 1.2 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DUF4407 PF14362.6 EFA75997.1 - 0.071 12.5 7.5 0.077 12.3 7.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.8 EFA75997.1 - 0.18 12.1 5.8 0.24 11.8 5.8 1.2 1 0 0 1 1 1 0 YlqD protein Alanine_zipper PF11839.8 EFA75997.1 - 1.6 9.1 25.1 2.8 8.4 25.1 1.3 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Plasmid_RAQPRD PF09686.10 EFA75997.1 - 6.6 7.0 12.0 5.3 7.3 3.8 2.7 2 1 1 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Presenilin PF01080.17 EFA75997.1 - 7 5.3 5.5 6.5 5.4 5.5 1.0 1 0 0 1 1 1 0 Presenilin Kelch_6 PF13964.6 EFA75998.1 - 4e-09 36.4 1.7 0.03 14.6 0.0 3.6 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFA75998.1 - 3.9e-08 33.2 3.0 3.8e-05 23.6 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA75998.1 - 4.8e-07 29.5 1.9 0.0059 16.6 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFA75998.1 - 0.00023 20.7 1.3 4.7 6.9 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFA75998.1 - 0.00029 20.8 5.6 0.048 13.7 0.3 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFA75998.1 - 0.023 15.0 0.2 2.3 8.6 0.0 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Fibrillarin PF01269.17 EFA75999.1 - 0.0062 15.7 0.9 0.0076 15.4 0.9 1.1 1 0 0 1 1 1 1 Fibrillarin DUF3781 PF12636.7 EFA75999.1 - 0.015 15.1 1.0 0.026 14.4 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3781) Selenoprotein_S PF06936.11 EFA75999.1 - 0.018 14.9 0.2 0.02 14.7 0.2 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) Latrotoxin_C PF15658.6 EFA75999.1 - 0.037 13.8 1.0 0.042 13.6 1.0 1.2 1 0 0 1 1 1 0 Latrotoxin C-terminal domain DUF3576 PF12100.8 EFA75999.1 - 0.083 13.0 0.4 0.12 12.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3576) rve PF00665.26 EFA76000.1 - 4.1e-11 43.1 0.1 4e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 EFA76000.1 - 6.5e-10 38.8 1.1 2.2e-09 37.1 1.1 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 EFA76000.1 - 2e-09 37.3 0.0 5.7e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EFA76000.1 - 1.5e-05 24.9 0.1 3.3e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF5341 PF17276.2 EFA76000.1 - 0.037 14.2 1.9 0.08 13.1 1.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5341) DASH_Dad4 PF08650.10 EFA76000.1 - 0.58 10.2 6.2 3 7.9 0.0 3.8 3 0 0 3 3 3 0 DASH complex subunit Dad4 CPSF100_C PF13299.6 EFA76001.1 - 0.046 13.9 3.9 0.037 14.2 1.8 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Ras PF00071.22 EFA76002.1 - 5.6e-14 52.1 0.4 5.6e-14 52.1 0.4 1.7 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFA76002.1 - 4.1e-10 39.9 1.1 1.3e-09 38.3 0.1 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA76002.1 - 0.00058 19.4 0.7 0.023 14.1 0.1 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF3385 PF11865.8 EFA76002.1 - 0.0035 17.3 3.8 0.36 10.7 0.8 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF3385) Mis14 PF08641.12 EFA76002.1 - 0.0092 16.3 2.8 0.018 15.3 2.8 1.7 1 1 0 1 1 1 1 Kinetochore protein Mis14 like ORC_WH_C PF18137.1 EFA76002.1 - 0.012 15.7 0.2 0.014 15.5 0.2 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal SUIM_assoc PF16619.5 EFA76002.1 - 0.025 14.6 1.6 0.048 13.7 1.6 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Meis_PKNOX_N PF16493.5 EFA76002.1 - 0.028 14.7 2.7 0.035 14.4 1.2 1.8 1 1 1 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 Kelch_6 PF13964.6 EFA76003.1 - 1.6e-11 44.1 4.3 0.036 14.4 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EFA76003.1 - 3.3e-07 30.2 7.4 0.00017 21.5 0.0 4.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA76003.1 - 7.5e-07 28.9 5.1 0.015 15.2 0.1 4.4 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA76003.1 - 1.1e-05 25.5 7.9 2e-05 24.7 7.9 1.4 1 0 0 1 1 1 1 B-box zinc finger Kelch_5 PF13854.6 EFA76003.1 - 1.8e-05 24.6 6.5 0.15 12.1 0.2 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 EFA76003.1 - 0.0017 17.9 6.3 14 5.4 0.1 5.4 5 1 0 5 5 5 2 Kelch motif FYVE PF01363.21 EFA76003.1 - 0.003 17.7 0.5 0.0079 16.3 0.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger Kelch_3 PF13415.6 EFA76003.1 - 0.18 12.1 0.8 10 6.5 0.0 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Ank_2 PF12796.7 EFA76004.1 - 7.5e-05 23.2 3.5 2.1 9.0 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeats (3 copies) DUF3447 PF11929.8 EFA76004.1 - 0.79 9.7 8.2 2.4 8.2 0.2 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF3447) Dimer_Tnp_hAT PF05699.14 EFA76005.1 - 1e-12 47.6 0.2 1e-12 47.6 0.2 2.7 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DSPn PF14671.6 EFA76005.1 - 0.039 14.4 0.1 0.098 13.1 0.1 1.6 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half POX PF07526.11 EFA76005.1 - 0.93 10.1 9.8 0.13 12.8 1.4 2.4 2 0 0 2 2 2 0 Associated with HOX TLP-20 PF06088.11 EFA76005.1 - 9.7 6.0 22.8 1.7 8.5 12.4 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Ras PF00071.22 EFA76006.1 - 2.6e-45 153.9 1.1 2.6e-45 153.9 1.1 2.4 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFA76006.1 - 5e-27 94.5 1.2 5e-27 94.5 1.2 2.9 3 1 1 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA76006.1 - 1.2e-14 54.1 0.1 1.2e-14 54.1 0.1 2.3 3 0 0 3 3 3 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA76006.1 - 3.2e-07 30.4 0.2 3.2e-07 30.4 0.2 3.8 3 1 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA76006.1 - 3e-05 23.6 0.2 0.00016 21.3 0.0 2.4 2 1 0 2 2 2 1 Ferrous iron transport protein B zf-B_box PF00643.24 EFA76006.1 - 0.0079 16.3 16.0 0.019 15.1 16.0 1.6 1 0 0 1 1 1 1 B-box zinc finger CCAP PF11105.8 EFA76006.1 - 0.11 12.5 2.8 0.46 10.4 2.8 2.1 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a RsgA_GTPase PF03193.16 EFA76006.1 - 0.16 11.8 8.3 3.4 7.5 0.0 3.7 4 1 0 4 4 4 0 RsgA GTPase DUF4637 PF15470.6 EFA76006.1 - 0.44 10.3 3.1 1.1 9.0 3.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HTH_6 PF01418.17 EFA76006.1 - 2 8.4 5.2 0.86 9.6 0.9 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family AAA_22 PF13401.6 EFA76006.1 - 2.8 8.2 7.2 2.6 8.3 0.0 3.4 2 2 1 3 3 3 0 AAA domain zf-UBP PF02148.19 EFA76006.1 - 3.6 8.0 13.9 0.53 10.6 9.0 2.2 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF1764 PF08576.10 EFA76008.1 - 4e-19 69.3 12.2 4e-19 69.3 12.2 2.4 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) CDC27 PF09507.10 EFA76008.1 - 0.18 11.2 26.1 0.22 10.9 26.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 KIAA1328 PF15369.6 EFA76008.1 - 0.24 11.2 17.5 0.28 11.0 17.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Med3 PF11593.8 EFA76008.1 - 0.3 10.2 16.8 0.38 9.9 16.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SMYLE_N PF18615.1 EFA76008.1 - 0.36 10.4 12.8 0.42 10.1 12.8 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Hamartin PF04388.12 EFA76008.1 - 1.7 7.2 18.0 1.7 7.2 18.0 1.0 1 0 0 1 1 1 0 Hamartin protein SprA-related PF12118.8 EFA76008.1 - 1.9 7.6 23.9 2.5 7.2 23.9 1.1 1 0 0 1 1 1 0 SprA-related family CDK5_activator PF03261.15 EFA76008.1 - 2.7 7.4 18.0 3.2 7.2 18.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein PA26 PF04636.13 EFA76008.1 - 3.4 6.5 9.9 3.7 6.3 9.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4661 PF15576.6 EFA76008.1 - 6.7 6.5 14.9 8.4 6.2 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) ORC6 PF05460.13 EFA76008.1 - 9.6 5.4 22.8 12 5.0 22.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Thioredoxin PF00085.20 EFA76009.1 - 5.8e-34 116.2 1.2 7e-25 87.0 0.1 4.0 3 1 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 EFA76009.1 - 1.7e-14 54.1 4.2 3.5e-06 27.0 0.1 3.2 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EFA76009.1 - 1.1e-09 38.7 0.3 0.0065 16.9 0.1 4.1 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFA76009.1 - 2e-06 28.1 1.0 0.35 11.2 0.1 4.1 3 1 1 4 4 4 3 Thioredoxin-like OST3_OST6 PF04756.13 EFA76009.1 - 1.6e-05 24.4 2.4 0.13 11.6 0.2 3.2 2 1 0 3 3 3 2 OST3 / OST6 family, transporter family HyaE PF07449.11 EFA76009.1 - 0.087 12.8 0.0 3.3 7.7 0.0 2.8 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EFA76009.1 - 0.14 12.4 0.1 0.76 10.0 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like TraF PF13728.6 EFA76009.1 - 0.85 9.4 10.2 3.4 7.4 0.0 3.6 4 0 0 4 4 4 0 F plasmid transfer operon protein ABC1 PF03109.16 EFA76010.1 - 0.00018 21.7 0.3 0.00055 20.1 0.0 2.0 2 0 0 2 2 2 1 ABC1 family Anoct_dimer PF16178.5 EFA76010.1 - 0.28 10.9 4.2 0.67 9.6 4.2 1.6 1 0 0 1 1 1 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin zf-C2H2_jaz PF12171.8 EFA76011.1 - 7.3e-05 22.9 5.5 0.062 13.6 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFA76011.1 - 0.00071 20.2 11.3 0.0024 18.6 0.6 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 EFA76011.1 - 0.0036 17.6 0.8 0.0036 17.6 0.8 2.8 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EFA76011.1 - 0.0065 16.9 11.3 0.0098 16.3 0.4 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type PyrI_C PF02748.15 EFA76011.1 - 0.78 9.7 5.3 1.4 8.9 1.1 2.3 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Ima1_N PF09779.9 EFA76011.1 - 2.2 9.1 11.3 17 6.3 11.3 2.2 1 1 0 1 1 1 0 Ima1 N-terminal domain SPX PF03105.19 EFA76011.1 - 5.9 6.7 9.2 13 5.5 9.2 1.5 1 1 0 1 1 1 0 SPX domain AAA_22 PF13401.6 EFA76012.1 - 1.9e-05 24.9 0.0 4.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFA76012.1 - 0.00039 20.4 0.0 0.00039 20.4 0.0 3.2 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA PF00004.29 EFA76012.1 - 0.0017 18.8 0.0 0.0052 17.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EFA76012.1 - 0.0071 15.8 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 EFA76012.1 - 0.0091 15.7 0.0 0.023 14.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 EFA76012.1 - 0.038 13.5 0.1 0.091 12.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EFA76012.1 - 0.2 11.6 2.1 11 5.9 0.1 2.7 2 1 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 EFA76013.1 - 2.5e-39 134.8 0.0 6.3e-39 133.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA76013.1 - 1.1e-25 90.1 0.0 6.6e-25 87.6 0.0 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EFA76013.1 - 0.056 12.8 0.0 0.056 12.8 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 EFA76013.1 - 0.13 12.6 1.1 2.1 8.6 1.1 2.9 1 1 0 1 1 1 0 AAA domain Nop14 PF04147.12 EFA76013.1 - 9.3 4.3 42.8 15 3.6 42.8 1.2 1 0 0 1 1 1 0 Nop14-like family Nbl1_Borealin_N PF10444.9 EFA76015.1 - 0.0017 17.9 0.6 0.29 10.8 0.1 2.5 1 1 1 2 2 2 2 Nbl1 / Borealin N terminal ZapA PF05164.13 EFA76015.1 - 0.02 15.3 1.4 28 5.2 0.0 3.1 2 1 1 3 3 3 0 Cell division protein ZapA CdvA PF18822.1 EFA76015.1 - 0.035 13.9 0.3 0.044 13.6 0.3 1.1 1 0 0 1 1 1 0 CdvA-like coiled-coil domain RVT_N PF13655.6 EFA76015.1 - 0.068 13.4 0.1 7.9 6.8 0.1 2.3 1 1 0 2 2 2 0 N-terminal domain of reverse transcriptase S_4TM PF18159.1 EFA76015.1 - 0.093 12.0 1.0 0.12 11.7 1.0 1.1 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Vpu PF00558.19 EFA76015.1 - 0.33 10.8 3.0 0.54 10.1 2.8 1.5 1 1 1 2 2 2 0 Vpu protein EGF_2 PF07974.13 EFA76016.1 - 0.00083 19.7 12.3 0.0019 18.5 12.3 1.6 1 0 0 1 1 1 1 EGF-like domain TIG PF01833.24 EFA76016.1 - 0.0095 16.0 1.4 0.047 13.8 1.4 2.3 1 0 0 1 1 1 1 IPT/TIG domain EB PF01683.18 EFA76016.1 - 0.01 16.1 2.9 0.026 14.8 2.9 1.6 1 0 0 1 1 1 0 EB module EGF_Tenascin PF18720.1 EFA76016.1 - 0.15 12.2 8.6 0.39 10.8 8.6 1.7 1 0 0 1 1 1 0 Tenascin EGF domain GST_C_3 PF14497.6 EFA76017.1 - 4.9e-21 74.8 0.1 7.4e-21 74.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA76017.1 - 2e-08 34.3 0.0 2.9e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA76017.1 - 1.6e-07 31.5 0.0 3.5e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA76017.1 - 8.6e-06 25.7 0.1 1.6e-05 24.9 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA76017.1 - 0.00013 22.3 0.0 0.00026 21.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFA76017.1 - 0.11 12.3 0.2 0.21 11.4 0.2 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain PMI_typeI PF01238.21 EFA76020.1 - 1.5e-101 340.3 0.0 2.3e-101 339.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 EFA76020.1 - 0.13 12.0 0.0 0.56 10.0 0.0 2.0 2 1 0 2 2 2 0 Cupin domain AraC_binding PF02311.19 EFA76020.1 - 0.17 11.8 0.0 0.95 9.4 0.0 2.1 2 0 0 2 2 2 0 AraC-like ligand binding domain ProRS-C_1 PF09180.11 EFA76021.1 - 6.7e-19 67.9 2.8 6.7e-19 67.9 2.8 2.2 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EFA76021.1 - 2e-18 67.0 0.0 4.4e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFA76021.1 - 5e-18 65.0 0.1 1.4e-17 63.6 0.1 1.9 1 0 0 1 1 1 1 Anticodon binding domain Bombinin PF05298.11 EFA76022.1 - 0.098 12.3 0.1 0.3 10.8 0.1 1.8 1 0 0 1 1 1 0 Bombinin Utp14 PF04615.13 EFA76022.1 - 0.76 8.3 44.1 0.035 12.7 30.3 2.2 2 0 0 2 2 2 0 Utp14 protein Mito_carr PF00153.27 EFA76024.1 - 1.2e-64 214.3 2.3 1.6e-20 72.8 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1899 PF08953.11 EFA76025.1 - 8.5e-15 54.4 0.5 2.3e-14 53.0 0.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EFA76025.1 - 1.9e-14 53.2 0.6 3.2e-14 52.5 0.6 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EFA76025.1 - 2e-06 28.4 4.7 0.0068 17.2 0.0 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76025.1 - 0.00019 21.6 0.0 0.0022 18.3 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain LRR_4 PF12799.7 EFA76026.1 - 3.2e-06 27.4 11.3 0.0073 16.7 0.0 4.3 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFA76026.1 - 0.00084 19.2 11.2 0.97 9.7 0.0 4.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.6 EFA76026.1 - 0.01 15.6 7.4 0.68 9.7 0.1 3.6 3 1 1 4 4 4 0 Leucine rich repeat LRR_1 PF00560.33 EFA76026.1 - 0.083 13.5 10.1 2.6 8.9 0.4 5.4 5 0 0 5 5 5 0 Leucine Rich Repeat RasGEF_N PF00618.20 EFA76027.1 - 6.9e-21 74.5 0.4 6.9e-21 74.5 0.4 4.2 3 0 0 3 3 3 1 RasGEF N-terminal motif RasGEF PF00617.19 EFA76027.1 - 8.6e-13 48.9 0.3 8.6e-13 48.9 0.3 2.9 2 1 1 3 3 3 1 RasGEF domain CH PF00307.31 EFA76027.1 - 1.3e-12 47.9 0.1 3.5e-12 46.4 0.1 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain Abhydrolase_1 PF00561.20 EFA76028.1 - 5.4e-10 39.3 0.0 2.2e-09 37.3 0.0 2.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Spt20 PF12090.8 EFA76028.1 - 0.14 11.7 10.6 0.22 11.1 10.6 1.2 1 0 0 1 1 1 0 Spt20 family Hydrolase_4 PF12146.8 EFA76028.1 - 0.26 10.5 0.0 0.26 10.5 0.0 3.7 3 2 0 3 3 3 0 Serine aminopeptidase, S33 DUF3915 PF13054.6 EFA76028.1 - 0.39 10.7 23.9 0.16 12.0 15.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3915) CDC45 PF02724.14 EFA76028.1 - 1.7 6.8 19.8 0.072 11.4 4.6 2.1 2 0 0 2 2 2 0 CDC45-like protein DDHD PF02862.17 EFA76028.1 - 2.5 8.2 8.1 0.33 11.1 2.6 2.1 2 0 0 2 2 2 0 DDHD domain Presenilin PF01080.17 EFA76028.1 - 2.6 6.7 17.5 3.5 6.3 9.6 2.3 2 0 0 2 2 2 0 Presenilin FAM60A PF15396.6 EFA76028.1 - 4.7 7.1 12.0 1.2 9.2 7.1 2.0 2 0 0 2 2 2 0 Protein Family FAM60A DUF4614 PF15391.6 EFA76028.1 - 5 7.1 18.2 0.11 12.4 10.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Response_reg PF00072.24 EFA76029.1 - 3.2e-17 62.7 0.1 1.2e-16 60.9 0.1 2.0 1 1 0 1 1 1 1 Response regulator receiver domain TFIIA PF03153.13 EFA76029.1 - 0.047 13.7 18.0 0.058 13.4 18.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GTA_holin_3TM PF11351.8 EFA76029.1 - 0.79 10.3 3.1 1.6 9.3 3.1 1.5 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release EBP50_C PF09007.11 EFA76029.1 - 5.8 7.9 8.0 1.4 9.9 2.8 2.2 2 0 0 2 2 2 0 EBP50, C-terminal Pox_A32 PF04665.12 EFA76030.1 - 4e-09 36.3 0.8 4e-09 36.3 0.8 1.6 2 0 0 2 2 2 1 Poxvirus A32 protein DAO PF01266.24 EFA76031.1 - 0.028 14.0 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase RhoGEF PF00621.20 EFA76032.1 - 2.9e-46 158.0 0.6 2.9e-46 158.0 0.6 3.2 4 0 0 4 4 4 1 RhoGEF domain CH PF00307.31 EFA76032.1 - 1.3e-21 76.8 0.5 7.4e-17 61.5 0.3 3.6 3 1 0 3 3 3 2 Calponin homology (CH) domain PH PF00169.29 EFA76032.1 - 2.8e-08 34.2 0.5 2.8e-08 34.2 0.5 3.3 3 0 0 3 3 3 1 PH domain PH_13 PF16652.5 EFA76032.1 - 0.00047 20.0 2.4 0.00047 20.0 2.4 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain Lipoprotein_2 PF00921.17 EFA76032.1 - 0.0062 16.1 8.3 0.0062 16.1 8.3 1.9 2 0 0 2 2 2 1 Borrelia lipoprotein CAMSAP_CH PF11971.8 EFA76032.1 - 0.029 14.2 5.1 0.27 11.1 0.1 3.5 4 0 0 4 4 4 0 CAMSAP CH domain CDC24 PF06395.11 EFA76032.1 - 0.66 10.3 5.2 0.23 11.8 0.3 2.9 3 0 0 3 3 3 0 CDC24 Calponin MFS_1_like PF12832.7 EFA76034.1 - 1.1e-68 231.9 15.3 3.9e-68 230.1 15.3 1.8 1 1 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 EFA76034.1 - 4.2e-28 98.3 41.5 1.3e-21 77.0 15.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 EFA76034.1 - 2.1e-12 46.7 25.6 1.5e-07 30.8 9.6 2.0 2 0 0 2 2 2 2 Nucleoside H+ symporter LacY_symp PF01306.19 EFA76034.1 - 1.1e-08 34.3 32.6 4.1e-08 32.4 11.4 2.1 2 0 0 2 2 2 2 LacY proton/sugar symporter K1 PF02960.14 EFA76034.1 - 0.37 10.9 1.3 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 K1 glycoprotein Metallophos PF00149.28 EFA76035.1 - 1.2e-19 71.6 1.3 1.2e-19 71.6 1.3 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFA76035.1 - 9.2e-19 68.1 0.1 3.8e-18 66.1 0.1 2.1 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EFA76035.1 - 2.5e-14 53.6 4.7 2.5e-14 53.6 4.7 1.9 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 EFA76035.1 - 0.00031 21.0 0.0 0.00093 19.4 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ribosomal_S2 PF00318.20 EFA76036.1 - 2.1e-25 89.2 1.7 6.4e-13 48.4 0.1 2.3 1 1 1 2 2 2 2 Ribosomal protein S2 ECH_1 PF00378.20 EFA76037.1 - 7.9e-45 153.1 1.9 1.5e-44 152.2 1.9 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFA76037.1 - 5.9e-20 72.0 0.9 2.2e-19 70.2 1.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase UvsY PF11056.8 EFA76038.1 - 0.051 13.9 0.2 0.051 13.9 0.2 2.2 2 0 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY MRP-S28 PF10213.9 EFA76038.1 - 0.062 13.7 4.4 0.23 11.9 3.1 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit protein DUF2052 PF09747.9 EFA76039.1 - 1e-14 55.2 39.0 1e-14 55.2 39.0 3.1 3 1 0 3 3 3 1 Coiled-coil domain containing protein (DUF2052) Ndc1_Nup PF09531.10 EFA76039.1 - 0.36 9.5 9.7 0.64 8.6 0.1 2.3 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup GWT1 PF06423.12 EFA76040.1 - 8.7e-19 68.1 13.1 8.7e-19 68.1 13.1 3.3 1 1 1 2 2 2 1 GWT1 TRAM1 PF08390.11 EFA76040.1 - 0.041 13.5 0.0 0.16 11.6 0.0 2.0 1 0 0 1 1 1 0 TRAM1-like protein Secretin_N_2 PF07655.13 EFA76040.1 - 0.91 10.1 11.2 1.7 9.2 11.2 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Pex14_N PF04695.13 EFA76040.1 - 1.3 9.7 3.7 7 7.3 3.8 2.0 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Jagunal PF07086.12 EFA76040.1 - 9.3 6.3 17.6 0.13 12.3 4.4 3.0 2 2 1 3 3 3 0 Jagunal, ER re-organisation during oogenesis Acyl-CoA_dh_M PF02770.19 EFA76041.1 - 1.5e-15 57.2 0.0 3e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain ACOX PF01756.19 EFA76041.1 - 4.6e-15 55.6 0.0 9.9e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 EFA76041.1 - 8e-09 35.9 2.4 5.1e-08 33.3 0.4 2.8 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Rpp20 PF12328.8 EFA76042.1 - 0.3 11.0 2.6 0.54 10.2 2.2 1.7 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Autophagy_N PF03986.13 EFA76042.1 - 6.3 6.7 8.1 11 6.0 2.7 2.7 3 0 0 3 3 3 0 Autophagocytosis associated protein (Atg3), N-terminal domain DUF3447 PF11929.8 EFA76043.1 - 5.4e-05 23.1 12.2 0.0012 18.7 0.1 5.2 5 1 1 6 6 6 3 Domain of unknown function (DUF3447) DUF3342 PF11822.8 EFA76043.1 - 0.061 13.5 0.4 4.3 7.6 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Ank_4 PF13637.6 EFA76043.1 - 0.13 12.9 0.1 3.1 8.5 0.0 3.5 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Med13_C PF06333.12 EFA76044.1 - 9.1 5.4 10.8 9.8 5.3 10.8 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Endotoxin_N PF03945.14 EFA76045.1 - 5.2e-05 23.1 7.0 0.00016 21.5 7.0 1.9 1 1 0 1 1 1 1 delta endotoxin, N-terminal domain UMP1 PF05348.11 EFA76046.1 - 6.9e-15 55.3 0.2 5.3e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 Proteasome maturation factor UMP1 TPR_1 PF00515.28 EFA76047.1 - 4.7e-25 86.3 17.5 4.1e-10 39.0 0.8 7.8 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76047.1 - 5.8e-25 85.4 11.2 9.3e-09 34.8 0.6 8.4 9 0 0 9 9 9 3 Tetratricopeptide repeat DnaJ PF00226.31 EFA76047.1 - 7.5e-22 77.2 9.9 8.5e-22 77.1 5.1 3.0 3 0 0 3 3 2 1 DnaJ domain TPR_16 PF13432.6 EFA76047.1 - 2.3e-21 76.1 1.2 0.01 16.4 0.0 6.7 4 3 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76047.1 - 6.4e-21 74.6 3.2 0.00017 22.1 0.2 6.1 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76047.1 - 1.6e-16 59.1 19.4 8.6e-06 25.6 0.3 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76047.1 - 1.8e-15 56.3 17.8 0.0054 16.4 0.2 8.2 5 3 3 8 8 8 6 TPR repeat TPR_9 PF13371.6 EFA76047.1 - 2.4e-15 56.4 0.7 4e-07 30.1 0.0 5.0 5 2 1 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA76047.1 - 5.9e-15 54.7 5.4 0.0051 17.5 0.0 6.3 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76047.1 - 3.2e-14 53.0 0.6 0.0035 17.6 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA76047.1 - 2.6e-09 37.2 3.4 0.00015 21.9 0.0 3.9 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFA76047.1 - 1.1e-08 35.2 7.9 0.0077 16.8 0.6 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA76047.1 - 3.2e-07 30.3 5.5 0.44 11.0 0.0 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFA76047.1 - 1.3e-06 27.8 6.4 0.72 9.0 0.0 4.6 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.6 EFA76047.1 - 2.1e-05 24.7 12.6 0.0077 16.5 0.4 5.4 3 3 3 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76047.1 - 2.6e-05 23.9 0.5 0.24 11.5 0.1 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFA76047.1 - 0.0004 20.1 6.0 5.4 7.0 0.1 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA76047.1 - 0.00056 19.4 0.1 2.8 7.2 0.3 3.9 2 1 2 4 4 4 1 MalT-like TPR region Alkyl_sulf_dimr PF14863.6 EFA76047.1 - 0.011 16.1 7.4 0.3 11.5 0.2 3.7 2 1 1 4 4 4 0 Alkyl sulfatase dimerisation DUF3741 PF12552.8 EFA76047.1 - 0.021 14.8 0.0 0.072 13.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3741) BTAD PF03704.17 EFA76047.1 - 0.024 15.1 0.1 9.1 6.7 0.0 3.8 2 2 0 3 3 3 0 Bacterial transcriptional activator domain DUF648 PF04890.13 EFA76047.1 - 0.05 13.4 0.2 0.17 11.6 0.1 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF648) HrpB1_HrpK PF09613.10 EFA76047.1 - 0.057 13.1 0.1 0.49 10.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF357 PF04010.13 EFA76047.1 - 0.2 11.8 3.0 4.9 7.3 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF357) Fis1_TPR_C PF14853.6 EFA76047.1 - 0.22 11.6 8.8 1.7 8.8 0.1 5.6 5 1 2 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat DUF4363 PF14276.6 EFA76047.1 - 0.53 10.4 7.0 1.5 9.0 0.5 4.5 4 1 2 6 6 5 0 Domain of unknown function (DUF4363) SHNi-TPR PF10516.9 EFA76047.1 - 0.73 9.3 5.1 19 4.8 0.0 3.9 4 0 0 4 4 4 0 SHNi-TPR DUF4398 PF14346.6 EFA76047.1 - 3 8.5 6.3 0.77 10.4 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) MA3 PF02847.17 EFA76048.1 - 3.3e-18 65.7 3.2 1.4e-17 63.7 3.2 2.2 1 0 0 1 1 1 1 MA3 domain Kelch_6 PF13964.6 EFA76049.1 - 2.8e-14 52.8 6.4 3.5e-09 36.6 0.2 5.2 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA76049.1 - 0.00069 19.2 0.5 0.0023 17.5 0.0 2.2 2 0 0 2 2 2 1 Kelch motif zf-B_box PF00643.24 EFA76049.1 - 0.0008 19.5 7.7 0.0022 18.1 7.7 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_5 PF13854.6 EFA76049.1 - 0.0081 16.1 0.9 0.024 14.7 0.9 1.8 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 EFA76049.1 - 0.068 13.2 1.6 0.48 10.5 0.1 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA76049.1 - 0.27 11.3 2.8 1.7 8.7 0.2 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain TPR_2 PF07719.17 EFA76050.1 - 1.6e-13 49.6 15.1 0.00015 21.6 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76050.1 - 2e-13 50.4 6.6 0.0015 18.8 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA76050.1 - 1.1e-11 44.1 15.6 9.5e-06 25.2 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat SET PF00856.28 EFA76050.1 - 1.3e-11 45.2 0.9 1.3e-11 45.2 0.9 3.2 2 1 0 2 2 1 1 SET domain zf-MYND PF01753.18 EFA76050.1 - 1.5e-05 25.0 9.7 1.5e-05 25.0 9.7 3.2 4 0 0 4 4 4 1 MYND finger TPR_8 PF13181.6 EFA76050.1 - 9.2e-05 22.4 9.8 0.18 12.1 0.3 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFA76050.1 - 0.00057 19.7 1.2 9.2 6.3 0.1 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA76050.1 - 0.017 15.7 6.1 0.24 12.1 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA76050.1 - 0.03 15.1 0.4 74 4.6 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76050.1 - 0.068 13.8 1.7 14 6.5 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat RSS_P20 PF11757.8 EFA76050.1 - 0.26 11.8 3.3 4.9 7.7 0.0 4.2 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain DUF5113 PF17140.4 EFA76050.1 - 8.9 6.1 9.2 6.5 6.5 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) IPK PF03770.16 EFA76051.1 - 2.1e-43 148.5 0.1 2.6e-43 148.2 0.1 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase LMF1 PF06762.14 EFA76052.1 - 8.7e-77 259.1 26.9 8.4e-45 153.7 2.9 2.8 2 1 1 3 3 3 2 Lipase maturation factor DUF2098 PF09871.9 EFA76052.1 - 0.15 12.4 0.4 0.38 11.1 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) COMM_domain PF07258.14 EFA76053.1 - 2.5e-21 75.6 0.0 6.3e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 COMM domain TIG PF01833.24 EFA76054.1 - 1.5e-49 166.0 211.5 6.7e-08 32.5 1.6 18.3 15 3 4 19 19 19 14 IPT/TIG domain EGF_2 PF07974.13 EFA76054.1 - 7.3 7.1 12.6 21 5.6 12.6 1.8 1 0 0 1 1 1 0 EGF-like domain TerD PF02342.18 EFA76056.1 - 0.24 10.9 1.3 0.35 10.3 0.1 1.8 2 0 0 2 2 2 0 TerD domain LSM PF01423.22 EFA76057.1 - 1.7e-13 50.0 0.4 4.2e-13 48.8 0.4 1.7 1 0 0 1 1 1 1 LSM domain CDC24 PF06395.11 EFA76057.1 - 0.38 11.0 0.1 0.38 11.0 0.1 2.1 2 0 0 2 2 2 0 CDC24 Calponin Androgen_recep PF02166.16 EFA76057.1 - 3 6.6 6.6 4.4 6.0 6.6 1.2 1 0 0 1 1 1 0 Androgen receptor 7tm_3 PF00003.22 EFA76058.1 - 3.3e-38 131.8 25.8 3.3e-38 131.8 25.8 2.6 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA76058.1 - 1.4e-23 83.4 1.9 1.9e-23 82.9 1.9 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like Phage_holin_8 PF16931.5 EFA76058.1 - 0.68 9.9 3.9 11 6.0 0.3 2.7 1 1 0 2 2 2 0 Putative phage holin MAP17 PF15807.5 EFA76058.1 - 8.1 6.7 8.8 0.41 10.9 0.2 2.8 2 1 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 RasGAP PF00616.19 EFA76059.1 - 1.1e-25 90.6 0.4 1.1e-25 90.6 0.4 4.0 2 2 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase VPS9 PF02204.18 EFA76059.1 - 2.5e-19 69.4 0.0 8.4e-19 67.7 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EFA76059.1 - 5.9e-05 23.3 5.4 6.4e-05 23.2 0.1 3.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) EB PF01683.18 EFA76060.1 - 0.0074 16.6 4.2 0.023 15.0 4.2 1.8 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 EFA76060.1 - 0.13 12.7 19.1 0.027 14.8 15.3 1.9 2 0 0 2 2 2 0 EGF-like domain Vps36-NZF-N PF16988.5 EFA76060.1 - 0.47 9.9 7.3 0.29 10.6 0.7 3.3 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Pex24p PF06398.11 EFA76061.1 - 0.034 13.1 0.1 0.05 12.6 0.1 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Methyltrans_RNA PF04452.14 EFA76061.1 - 0.038 13.3 0.1 0.055 12.8 0.1 1.2 1 0 0 1 1 1 0 RNA methyltransferase TMEM100 PF16311.5 EFA76061.1 - 0.079 12.5 2.0 0.16 11.6 1.4 1.9 1 1 0 1 1 1 0 Transmembrane protein 100 PepSY_TM PF03929.16 EFA76061.1 - 0.73 9.5 2.6 0.85 9.2 0.0 2.2 2 1 0 2 2 2 0 PepSY-associated TM region zf-B_box PF00643.24 EFA76062.1 - 1.6e-08 34.6 6.2 3.3e-08 33.5 6.2 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA76062.1 - 1.9e-08 34.3 8.6 0.0095 16.2 0.1 4.8 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EFA76062.1 - 3.7e-05 23.6 1.1 0.28 11.2 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA76062.1 - 0.00025 20.6 5.6 0.0082 15.7 0.0 3.6 4 0 0 4 4 4 2 Kelch motif RlaP PF10127.9 EFA76062.1 - 0.027 14.1 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA repair pathway DNA polymerase beta family Kelch_2 PF07646.15 EFA76062.1 - 0.03 14.3 3.2 1.5 9.0 0.0 4.0 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 EFA76062.1 - 0.11 12.6 16.6 12 6.1 0.0 5.7 5 0 0 5 5 5 0 Kelch motif Noggin PF05806.12 EFA76062.1 - 0.38 10.6 1.6 0.79 9.6 1.6 1.5 1 0 0 1 1 1 0 Noggin Guanylate_cyc PF00211.20 EFA76063.1 - 1.1e-27 96.9 0.5 2.6e-27 95.6 0.5 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HATPase_c PF02518.26 EFA76063.1 - 2.4e-16 60.2 0.5 6.7e-09 36.2 0.0 3.2 1 1 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA76063.1 - 7.7e-09 35.7 5.0 1.1e-06 28.8 0.0 3.9 4 0 0 4 4 4 1 Response regulator receiver domain TPR_2 PF07719.17 EFA76063.1 - 0.0082 16.2 0.0 0.019 15.0 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF5308 PF17233.2 EFA76063.1 - 0.049 13.9 10.3 0.061 13.6 0.6 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5308) TPR_1 PF00515.28 EFA76063.1 - 0.13 12.2 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat AP3D1 PF06375.11 EFA76063.1 - 0.88 9.8 35.1 0.36 11.1 16.3 2.8 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 RPOL_N PF14700.6 EFA76063.1 - 3.9 6.8 17.5 2.7 7.3 6.6 3.0 3 0 0 3 3 3 0 DNA-directed RNA polymerase N-terminal RNA_pol_Rpc4 PF05132.14 EFA76063.1 - 4.5 7.7 13.9 14 6.1 5.3 2.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 ALG3 PF05208.13 EFA76064.1 - 2.6e-54 185.0 0.6 3.5e-54 184.6 0.6 1.1 1 0 0 1 1 1 1 ALG3 protein Tautomerase_2 PF14552.6 EFA76064.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Tautomerase enzyme Kelch_4 PF13418.6 EFA76065.1 - 1.8e-10 40.7 11.7 1.1e-07 31.8 0.1 5.8 5 1 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA76065.1 - 4.5e-08 32.5 17.5 0.0056 16.2 0.0 6.3 5 1 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 EFA76065.1 - 3.3e-06 27.2 18.1 0.036 14.3 0.6 5.6 3 2 2 5 5 5 2 Kelch motif Kelch_3 PF13415.6 EFA76065.1 - 0.00014 22.1 8.5 0.0078 16.5 0.0 4.4 5 0 0 5 5 5 2 Galactose oxidase, central domain zf-B_box PF00643.24 EFA76065.1 - 0.00053 20.1 11.5 0.00053 20.1 11.5 2.4 2 0 0 2 2 2 1 B-box zinc finger Kelch_2 PF07646.15 EFA76065.1 - 0.39 10.8 10.0 10 6.3 0.1 5.1 6 0 0 6 6 6 0 Kelch motif RP-C_C PF11800.8 EFA76065.1 - 0.49 10.5 9.0 0.85 9.7 9.0 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region CAC1F_C PF16885.5 EFA76065.1 - 1.5 8.4 8.7 2.2 7.8 8.7 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term ALMT PF11744.8 EFA76065.1 - 7.4 5.3 12.8 11 4.7 12.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter HSBP1 PF06825.12 EFA76067.1 - 0.009 15.8 1.3 0.033 14.0 0.1 2.6 2 0 0 2 2 2 1 Heat shock factor binding protein 1 DUF1664 PF07889.12 EFA76067.1 - 0.012 15.7 2.9 0.012 15.7 2.9 3.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EFA76067.1 - 0.02 15.1 0.9 0.02 15.1 0.9 4.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Rb_C PF08934.10 EFA76067.1 - 0.041 13.7 5.5 0.16 11.8 5.5 2.0 1 0 0 1 1 1 0 Rb C-terminal domain Orthopox_B11R PF07033.11 EFA76067.1 - 0.4 10.5 4.4 0.27 11.0 0.6 2.8 2 0 0 2 2 2 0 Orthopoxvirus B11R protein CorA PF01544.18 EFA76067.1 - 1.3 8.3 19.0 0.03 13.6 3.8 2.8 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein LPP PF04728.13 EFA76067.1 - 3.9 7.9 17.7 3.2 8.2 0.2 4.7 3 1 1 4 4 4 0 Lipoprotein leucine-zipper DUF3439 PF11921.8 EFA76067.1 - 9.1 6.3 14.5 3 7.8 8.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Kelch_6 PF13964.6 EFA76068.1 - 1.8e-14 53.4 15.6 0.00038 20.6 0.1 5.5 3 2 2 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EFA76068.1 - 2.9e-14 52.8 12.2 1.2e-06 28.4 0.1 5.9 4 2 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA76068.1 - 2e-12 47.1 9.2 6.8e-05 23.0 0.1 6.8 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA76068.1 - 1.3e-11 43.9 9.4 0.00024 20.6 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EFA76068.1 - 0.00018 21.4 22.8 0.31 11.1 0.0 5.2 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFA76068.1 - 0.0016 18.4 8.5 1.4 9.0 0.0 4.5 5 0 0 5 5 5 2 Kelch motif DUF1115 PF06544.12 EFA76068.1 - 0.038 14.1 0.7 0.038 14.1 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1115) Secretin_N_2 PF07655.13 EFA76068.1 - 0.5 10.9 30.5 0.15 12.7 8.1 3.4 3 0 0 3 3 3 0 Secretin N-terminal domain Methyltransf_12 PF08242.12 EFA76068.1 - 2.2 9.1 10.6 20 6.0 0.5 3.6 3 0 0 3 3 3 0 Methyltransferase domain Prenyltrans PF00432.21 EFA76070.1 - 6.3e-56 185.8 5.7 2.2e-13 49.7 0.1 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Pkinase PF00069.25 EFA76070.1 - 4.9e-44 150.7 13.6 9.3e-20 71.1 4.4 3.8 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76070.1 - 2e-31 109.2 1.7 2.3e-16 59.9 1.2 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase SQHop_cyclase_C PF13243.6 EFA76070.1 - 0.00011 21.5 0.1 0.0045 16.1 0.0 2.5 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain FTA2 PF13095.6 EFA76070.1 - 0.023 14.4 0.5 0.062 12.9 0.5 1.7 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 EFA76071.1 - 0.00025 21.8 12.4 0.92 10.5 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76071.1 - 0.0017 18.6 0.1 0.19 12.1 0.0 3.1 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EFA76072.1 - 3.2e-32 111.0 1.3 2.1e-14 53.8 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76072.1 - 1e-29 102.5 0.8 2.6e-14 53.4 0.1 4.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA76072.1 - 1.1e-26 92.1 1.7 0.00028 21.2 0.0 6.1 5 1 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFA76072.1 - 3.6e-25 85.3 2.5 1.1e-05 25.5 0.5 6.0 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFA76072.1 - 5.9e-24 83.8 0.6 7.2e-09 35.7 0.6 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) PH PF00169.29 EFA76072.1 - 9.5e-12 45.4 0.3 2.8e-11 43.9 0.1 1.9 2 0 0 2 2 2 1 PH domain DUF4869 PF16163.5 EFA76072.1 - 0.1 12.3 1.0 0.82 9.4 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4869) ExbD PF02472.16 EFA76072.1 - 0.18 12.0 0.5 0.73 10.0 0.5 2.0 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR PAXX PF15384.6 EFA76073.1 - 0.014 15.1 1.7 0.014 15.1 1.7 1.8 2 0 0 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Exonuc_VII_L PF02601.15 EFA76073.1 - 8.3 5.9 15.5 4.5 6.8 2.3 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit SMC_Nse1 PF07574.13 EFA76074.1 - 0.14 12.0 1.3 0.28 11.0 1.3 1.4 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex DUF1161 PF06649.12 EFA76074.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1161) BSP_II PF05432.11 EFA76075.1 - 0.0021 17.8 21.2 0.0025 17.6 21.2 1.0 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DUF4746 PF15928.5 EFA76075.1 - 0.012 15.1 16.8 0.016 14.7 16.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PNISR PF15996.5 EFA76075.1 - 0.073 13.4 22.9 0.095 13.0 22.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR AAA_13 PF13166.6 EFA76075.1 - 0.14 10.8 21.4 0.17 10.5 21.4 1.0 1 0 0 1 1 1 0 AAA domain D-ser_dehydrat PF14031.6 EFA76075.1 - 0.16 12.6 1.4 0.22 12.2 1.0 1.5 1 1 0 1 1 1 0 Putative serine dehydratase domain TFIIF_alpha PF05793.12 EFA76075.1 - 0.46 9.0 35.5 0.59 8.7 35.4 1.2 1 1 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM60A PF15396.6 EFA76075.1 - 0.64 10.0 16.2 0.8 9.7 16.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SAPS PF04499.15 EFA76075.1 - 3.5 6.3 14.6 3.8 6.2 14.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 EFA76075.1 - 4.4 5.5 17.5 5.2 5.2 17.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4551 PF15087.6 EFA76075.1 - 5.5 5.7 14.4 6 5.6 14.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) ALMT PF11744.8 EFA76075.1 - 6.9 5.4 13.0 8.2 5.1 13.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PIEZO PF15917.5 EFA76075.1 - 7.5 6.0 15.4 9.7 5.6 15.4 1.3 1 0 0 1 1 1 0 Piezo CDK5_activator PF03261.15 EFA76075.1 - 7.6 6.0 14.3 8.8 5.8 14.3 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein FERM_M PF00373.18 EFA76076.1 - 2.5e-13 50.5 0.0 3.9e-12 46.6 0.0 2.4 1 1 0 1 1 1 1 FERM central domain LRR_6 PF13516.6 EFA76076.1 - 1.6e-09 37.0 29.9 0.077 13.1 0.2 10.7 12 0 0 12 12 12 4 Leucine Rich repeat FERM_N PF09379.10 EFA76076.1 - 3.4e-08 33.3 0.0 1.4e-07 31.3 0.0 2.2 2 0 0 2 2 2 1 FERM N-terminal domain LRR_1 PF00560.33 EFA76076.1 - 0.014 15.9 19.2 9.2 7.3 0.0 9.7 12 0 0 12 12 12 0 Leucine Rich Repeat LRR_4 PF12799.7 EFA76076.1 - 1 9.8 34.8 1.2 9.7 0.6 8.9 6 2 1 8 8 8 0 Leucine Rich repeats (2 copies) IMUP PF15761.5 EFA76077.1 - 0.05 14.3 1.8 0.05 14.3 1.8 2.8 3 0 0 3 3 3 0 Immortalisation up-regulated protein Mucin PF01456.17 EFA76077.1 - 0.63 10.0 44.2 2.7 8.0 16.6 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein AF-4 PF05110.13 EFA76077.1 - 0.92 7.5 34.0 1.2 7.2 34.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SET PF00856.28 EFA76078.1 - 1.9e-13 51.2 0.8 5.8e-12 46.3 0.0 2.7 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EFA76078.1 - 9.8e-11 42.5 10.8 1.5e-09 38.6 4.3 3.3 3 1 0 3 3 3 2 Rubisco LSMT substrate-binding Voldacs PF03517.13 EFA76078.1 - 0.13 12.4 16.3 0.52 10.4 16.3 2.0 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF4611 PF15387.6 EFA76078.1 - 3.1 8.1 26.1 4.3 7.6 11.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Guanylate_cyc PF00211.20 EFA76079.1 - 1.9e-77 259.0 2.0 3.9e-41 140.7 1.2 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EFA76079.1 - 0.0096 15.4 0.7 3.4 7.0 0.1 2.7 2 0 0 2 2 2 2 Heme NO binding associated AIG1 PF04548.16 EFA76080.1 - 8.5e-22 77.5 0.0 1.7e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EFA76080.1 - 6.3e-10 39.1 0.0 1.4e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA76080.1 - 2.9e-05 24.1 0.4 6.3e-05 22.9 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 EFA76080.1 - 0.00031 20.1 0.5 0.0019 17.5 0.1 2.4 2 1 0 2 2 2 1 Septin AAA_16 PF13191.6 EFA76080.1 - 0.0026 18.2 0.0 0.0072 16.7 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EFA76080.1 - 0.0037 17.3 6.8 0.021 14.9 0.1 3.3 2 2 1 3 3 3 1 Dynamin family ABC_tran PF00005.27 EFA76080.1 - 0.0077 16.7 0.4 0.11 13.1 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 EFA76080.1 - 0.011 15.2 0.0 0.047 13.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 EFA76080.1 - 0.023 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B T2SSE PF00437.20 EFA76080.1 - 0.026 13.6 0.1 0.045 12.8 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF815 PF05673.13 EFA76080.1 - 0.031 13.4 0.2 0.079 12.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Gtr1_RagA PF04670.12 EFA76080.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 EFA76080.1 - 0.06 12.7 0.4 0.16 11.3 0.0 1.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family LRR_8 PF13855.6 EFA76081.1 - 0.00019 21.1 0.4 0.0012 18.6 0.1 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EFA76081.1 - 0.0017 18.7 4.8 0.48 10.9 0.8 2.4 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA76081.1 - 0.093 13.3 0.3 7.6 7.5 0.1 2.7 2 0 0 2 2 2 0 Leucine Rich Repeat RasGAP PF00616.19 EFA76082.1 - 1.2e-11 44.7 6.0 1.2e-07 31.7 2.4 2.6 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase Myb_DNA-bind_6 PF13921.6 EFA76083.1 - 0.0003 21.0 0.1 0.00078 19.6 0.1 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFA76083.1 - 0.00039 20.6 0.0 0.004 17.3 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EFA76083.1 - 0.01 15.9 1.1 0.14 12.3 1.1 2.5 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFA76083.1 - 0.077 13.4 0.4 0.14 12.5 0.1 1.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Inhibitor_I36 PF03995.13 EFA76084.1 - 0.0011 18.8 1.2 0.0017 18.3 1.2 1.3 1 0 0 1 1 1 1 Peptidase inhibitor family I36 DUF1771 PF08590.10 EFA76085.1 - 7.5e-17 61.5 10.0 7.5e-17 61.5 10.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) CUE PF02845.16 EFA76085.1 - 5.6e-08 32.3 10.7 3.5e-05 23.4 0.2 5.2 4 0 0 4 4 4 2 CUE domain Smr PF01713.21 EFA76085.1 - 4.7e-06 26.9 0.1 1.4e-05 25.4 0.1 1.9 1 0 0 1 1 1 1 Smr domain TACI-CRD2 PF09305.10 EFA76085.1 - 0.0051 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 TACI, cysteine-rich domain EGF_2 PF07974.13 EFA76086.1 - 0.0019 18.5 14.0 0.0038 17.6 14.0 1.5 1 0 0 1 1 1 1 EGF-like domain DUF5305 PF17231.2 EFA76086.1 - 0.015 14.7 0.7 0.028 13.8 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5305) DUF3844 PF12955.7 EFA76086.1 - 0.035 14.3 2.4 0.085 13.0 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) CD34_antigen PF06365.12 EFA76086.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family EphA2_TM PF14575.6 EFA76086.1 - 0.077 13.9 0.3 0.14 13.0 0.3 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Spc7_C2 PF15577.6 EFA76086.1 - 0.16 12.1 0.3 4.5 7.4 0.0 2.6 2 0 0 2 2 2 0 Spc7_C2 Ras PF00071.22 EFA76087.1 - 7.3e-73 243.5 8.4 1.6e-44 151.4 0.1 4.8 4 1 1 5 5 5 3 Ras family Roc PF08477.13 EFA76087.1 - 1.2e-40 138.4 0.2 8.5e-26 90.5 0.0 3.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase CBM49 PF09478.10 EFA76087.1 - 2.1e-23 82.4 1.4 3.6e-17 62.5 0.2 5.6 5 0 0 5 5 2 2 Carbohydrate binding domain CBM49 Arf PF00025.21 EFA76087.1 - 2.5e-15 56.4 0.1 3.6e-11 42.8 0.0 3.1 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA76087.1 - 1.4e-08 34.8 16.5 8.3e-05 22.6 0.0 5.7 6 1 1 7 7 7 2 50S ribosome-binding GTPase TniB PF05621.11 EFA76087.1 - 7.6e-06 25.5 0.0 0.11 11.8 0.0 3.0 2 0 0 2 2 2 2 Bacterial TniB protein zf-UBP PF02148.19 EFA76087.1 - 0.00015 22.0 23.0 0.047 14.0 7.4 3.2 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein DUF3450 PF11932.8 EFA76087.1 - 0.0017 17.7 10.7 0.099 11.9 1.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3450) AAA_24 PF13479.6 EFA76087.1 - 0.0032 17.2 2.8 0.47 10.1 0.0 4.1 4 0 0 4 4 4 1 AAA domain FlgN PF05130.12 EFA76087.1 - 0.011 16.2 15.1 0.45 11.0 3.1 2.8 2 0 0 2 2 2 0 FlgN protein HTH_6 PF01418.17 EFA76087.1 - 0.032 14.2 3.6 0.55 10.2 0.4 3.9 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family AAA_22 PF13401.6 EFA76087.1 - 0.04 14.2 1.4 12 6.2 0.0 4.1 4 1 0 4 4 4 0 AAA domain AAA_16 PF13191.6 EFA76087.1 - 0.11 12.9 0.0 2.6 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain Sprouty PF05210.13 EFA76087.1 - 0.21 12.0 12.6 2.1 8.8 2.5 2.6 2 0 0 2 2 2 0 Sprouty protein (Spry) FtsX_ECD PF18075.1 EFA76087.1 - 0.26 12.0 20.1 0.34 11.6 0.7 4.5 5 0 0 5 5 3 0 FtsX extracellular domain DUF3910 PF13049.6 EFA76087.1 - 0.54 10.6 12.5 14 6.1 0.6 5.1 5 0 0 5 5 4 0 Protein of unknown function (DUF3910) Cob_adeno_trans PF01923.18 EFA76087.1 - 0.72 10.0 8.0 5.2 7.2 1.0 3.3 2 1 0 2 2 2 0 Cobalamin adenosyltransferase Integrase_1 PF12835.7 EFA76087.1 - 0.72 10.0 0.0 0.72 10.0 0.0 3.5 4 0 0 4 4 4 0 Integrase Zn_Tnp_IS91 PF14319.6 EFA76087.1 - 1.4 9.1 17.9 2.8 8.1 5.2 2.8 2 0 0 2 2 2 0 Transposase zinc-binding domain DUF948 PF06103.11 EFA76087.1 - 2.1 8.6 6.6 27 5.1 0.6 3.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) CLZ PF16526.5 EFA76087.1 - 2.4 8.6 6.5 18 5.8 1.1 3.1 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4637 PF15470.6 EFA76087.1 - 3.4 7.4 19.1 6.2 6.5 5.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Turandot PF07240.11 EFA76087.1 - 4.9 7.2 6.7 43 4.2 0.5 3.4 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot RPW8 PF05659.11 EFA76087.1 - 5.2 6.8 14.2 41 3.9 0.2 5.1 2 2 2 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 IBR PF01485.21 EFA76087.1 - 6.7 7.0 22.1 13 6.1 7.1 2.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain FYVE PF01363.21 EFA76087.1 - 8 6.7 14.7 13 6.0 3.3 2.9 2 0 0 2 2 2 0 FYVE zinc finger CBM49 PF09478.10 EFA76088.1 - 5.9e-17 61.8 0.7 1.6e-16 60.3 0.1 2.1 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 LRR_9 PF14580.6 EFA76088.1 - 1.7e-14 53.7 4.4 4.2e-14 52.4 4.4 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFA76088.1 - 5.4e-13 48.9 17.3 2.5e-06 27.7 2.7 3.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA76088.1 - 4e-11 42.5 16.6 1.6e-09 37.3 1.2 3.6 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 EFA76088.1 - 0.011 15.7 19.1 0.14 12.3 0.2 4.4 4 0 0 4 4 4 0 Leucine Rich repeat Endotoxin_N PF03945.14 EFA76090.1 - 3e-18 66.4 7.3 5e-18 65.6 7.3 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain DUF4199 PF13858.6 EFA76090.1 - 0.069 13.5 0.4 0.15 12.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) CBM49 PF09478.10 EFA76091.1 - 5.3e-18 65.1 0.2 7.4e-18 64.6 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Myticin-prepro PF10690.9 EFA76091.1 - 0.032 14.5 0.3 0.049 13.9 0.3 1.4 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel CBM_2 PF00553.19 EFA76091.1 - 0.036 14.4 0.7 0.061 13.6 0.7 1.4 1 0 0 1 1 1 0 Cellulose binding domain G8 PF10162.9 EFA76092.1 - 2.7e-24 85.6 0.1 6.9e-24 84.3 0.1 1.8 1 0 0 1 1 1 1 G8 domain PHP PF02811.19 EFA76093.1 - 0.00019 21.8 0.0 0.00066 20.0 0.0 1.5 1 1 0 1 1 1 1 PHP domain SOG2 PF10428.9 EFA76094.1 - 0.67 9.1 30.5 0.18 11.0 7.3 2.4 2 0 0 2 2 2 0 RAM signalling pathway protein RVT_1 PF00078.27 EFA76095.1 - 1.4e-41 142.5 0.3 3.4e-41 141.2 0.3 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) G-alpha PF00503.20 EFA76096.1 - 1.6e-105 353.2 2.6 1.9e-105 352.9 2.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA76096.1 - 8.6e-15 54.6 6.2 1.7e-11 43.9 1.7 2.7 2 2 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA76096.1 - 1.4e-05 24.5 0.7 0.0036 16.7 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA76096.1 - 3.4e-05 24.1 0.2 0.076 13.2 0.2 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase PglD_N PF17836.1 EFA76096.1 - 0.018 15.7 0.4 0.25 12.0 0.0 2.6 3 0 0 3 3 3 0 PglD N-terminal domain CPT PF07931.12 EFA76096.1 - 0.15 11.9 0.0 0.4 10.5 0.0 1.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DSPc PF00782.20 EFA76097.1 - 1.1e-32 112.7 0.6 1.4e-32 112.3 0.2 1.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA76097.1 - 0.0024 17.5 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFA76097.1 - 0.039 14.3 0.0 0.072 13.4 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFA76097.1 - 0.092 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Ribosomal_60s PF00428.19 EFA76098.1 - 5.7e-26 90.9 13.8 6.7e-26 90.7 13.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2057 PF09829.9 EFA76098.1 - 0.88 9.7 4.0 1.1 9.4 4.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Pkinase_Tyr PF07714.17 EFA76099.1 - 4.8e-61 206.3 0.0 1.1e-60 205.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA76099.1 - 4.8e-54 183.5 0.0 9.6e-54 182.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain ANAPC4_WD40 PF12894.7 EFA76099.1 - 7.5e-05 23.0 1.0 0.12 12.6 0.1 3.7 1 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA76099.1 - 0.0001 23.0 5.9 0.12 13.3 0.0 5.0 6 0 0 6 6 6 2 WD domain, G-beta repeat PIG-X PF08320.12 EFA76100.1 - 2.3e-30 106.1 2.5 9.9e-30 104.0 2.5 2.1 1 1 0 1 1 1 1 PIG-X / PBN1 DUF4064 PF13273.6 EFA76100.1 - 0.0019 18.4 3.9 7 7.0 0.0 3.4 3 0 0 3 3 3 3 Protein of unknown function (DUF4064) OPA3 PF07047.12 EFA76100.1 - 0.18 11.5 1.8 1.6 8.5 0.0 2.7 3 0 0 3 3 3 0 Optic atrophy 3 protein (OPA3) EphA2_TM PF14575.6 EFA76100.1 - 0.72 10.8 6.0 13 6.8 0.0 3.8 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain SUIM_assoc PF16619.5 EFA76100.1 - 1.3 9.1 30.3 0.19 11.8 8.1 3.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Trp_Tyr_perm PF03222.13 EFA76101.1 - 0.00039 19.6 0.4 0.00055 19.1 0.4 1.2 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 EFA76101.1 - 0.0068 15.2 0.6 0.0079 15.0 0.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 EFA76102.1 - 8.4e-07 28.0 8.3 1.7e-06 27.0 8.3 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein ABC_tran PF00005.27 EFA76103.1 - 7.2e-22 78.4 0.1 7.2e-20 71.9 0.1 2.4 1 1 0 1 1 1 1 ABC transporter Yae1_N PF09811.9 EFA76104.1 - 1.9e-09 37.0 3.9 3.2e-09 36.3 3.9 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Myb_DNA-binding PF00249.31 EFA76104.1 - 0.00028 21.0 0.0 0.00056 20.0 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4896 PF16237.5 EFA76105.1 - 0.16 11.8 2.3 0.28 11.1 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4896) TIG PF01833.24 EFA76106.1 - 5e-09 36.1 32.4 5.2e-09 36.1 0.8 5.3 5 1 0 5 5 5 4 IPT/TIG domain EGF_2 PF07974.13 EFA76106.1 - 0.031 14.6 15.6 0.069 13.5 15.6 1.6 1 0 0 1 1 1 0 EGF-like domain p450 PF00067.22 EFA76107.1 - 3.5e-88 296.4 0.0 4e-88 296.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 A_deaminase PF00962.22 EFA76108.1 - 1.7e-119 399.0 0.1 2.3e-119 398.6 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase MIP PF00230.20 EFA76109.1 - 1e-51 175.9 16.8 1.2e-51 175.6 16.8 1.0 1 0 0 1 1 1 1 Major intrinsic protein Sulfate_transp PF00916.20 EFA76110.1 - 4.1e-96 322.0 18.1 1.7e-94 316.7 18.1 2.2 1 1 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFA76110.1 - 8.1e-17 60.9 0.1 1.3e-16 60.3 0.1 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFA76110.1 - 0.0098 16.3 2.1 0.0098 16.3 2.1 3.5 4 1 0 4 4 4 1 Molybdate transporter of MFS superfamily TM_helix PF05552.12 EFA76110.1 - 8 6.5 7.9 18 5.4 1.0 3.7 3 0 0 3 3 3 0 Conserved TM helix CMAS PF02353.20 EFA76111.1 - 0.00015 21.1 0.1 0.00015 21.1 0.1 1.8 3 0 0 3 3 3 1 Mycolic acid cyclopropane synthetase RrnaAD PF00398.20 EFA76111.1 - 0.024 13.7 0.3 0.024 13.7 0.3 1.7 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase DUF1365 PF07103.11 EFA76112.1 - 4.1e-13 49.5 0.1 6.6e-13 48.9 0.0 1.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1365) PALP PF00291.25 EFA76113.1 - 1.6e-68 231.3 0.0 4.8e-68 229.7 0.0 1.8 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EFA76113.1 - 3.3e-18 65.9 0.1 4.9e-10 39.7 0.0 3.1 2 1 1 3 3 3 2 CBS domain DUF4449 PF14613.6 EFA76114.1 - 4.1e-06 27.0 5.7 1.3e-05 25.4 5.7 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) HIGH_NTase1_ass PF16581.5 EFA76114.1 - 0.008 16.2 0.7 0.008 16.2 0.7 2.6 3 0 0 3 3 3 1 Cytidyltransferase-related C-terminal region SKA1 PF07160.12 EFA76114.1 - 0.077 12.8 3.6 0.19 11.5 3.6 1.7 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Ku_PK_bind PF08785.11 EFA76114.1 - 0.24 11.5 2.6 4.5 7.4 0.0 3.3 3 1 1 4 4 4 0 Ku C terminal domain like SNARE PF05739.19 EFA76115.1 - 2.6e-10 40.1 0.3 2.6e-10 40.1 0.3 1.9 2 0 0 2 2 2 1 SNARE domain BRE1 PF08647.11 EFA76115.1 - 0.0012 18.9 0.3 0.0012 18.9 0.3 2.2 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase Syntaxin PF00804.25 EFA76115.1 - 0.0046 16.7 0.8 0.0046 16.7 0.8 2.0 2 0 0 2 2 2 1 Syntaxin MCPsignal PF00015.21 EFA76115.1 - 0.0093 15.8 2.0 0.013 15.3 2.0 1.4 1 1 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF641 PF04859.12 EFA76115.1 - 0.2 12.0 2.9 11 6.4 1.7 2.6 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EFA76115.1 - 1.8 9.2 4.5 3 8.5 0.3 2.5 2 1 1 3 3 3 0 SlyX FlaC_arch PF05377.11 EFA76115.1 - 5.4 7.5 7.8 1 9.8 2.6 2.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Peptidase_C1 PF00112.23 EFA76118.1 - 3e-47 161.5 3.6 3e-47 161.5 3.6 1.5 2 0 0 2 2 2 1 Papain family cysteine protease CAP PF00188.26 EFA76118.1 - 3.5e-06 27.9 0.1 7.6e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C39_2 PF13529.6 EFA76118.1 - 0.0016 19.0 2.1 0.0021 18.6 0.1 2.1 2 0 0 2 2 2 1 Peptidase_C39 like family Peptidase_C1_2 PF03051.15 EFA76118.1 - 0.0084 14.9 1.2 0.27 9.9 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family DUF3343 PF11823.8 EFA76118.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) Nucleo_P87 PF07267.11 EFA76118.1 - 6.4 5.5 21.4 9.3 5.0 21.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Inhibitor_I29 PF08246.12 EFA76119.1 - 2.5e-10 40.6 1.2 6.9e-09 36.0 1.2 2.5 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF3042 PF11240.8 EFA76119.1 - 0.021 14.8 4.3 0.068 13.2 4.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3042) 2-Hacid_dh_C PF02826.19 EFA76120.1 - 3.5e-60 202.4 0.0 4.7e-60 202.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFA76120.1 - 3.9e-21 75.1 0.0 4.7e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 EFA76120.1 - 0.013 16.1 0.1 0.029 14.9 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 EFA76120.1 - 0.032 14.3 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EFA76120.1 - 0.11 12.1 0.1 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Glyco_hydro_63 PF03200.16 EFA76121.1 - 1.9e-157 525.0 7.1 3.7e-156 520.7 7.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EFA76121.1 - 9.2e-51 173.1 0.4 9.2e-51 173.1 0.4 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain PDCD2_C PF04194.13 EFA76121.1 - 1.6 8.8 3.8 16 5.5 0.0 2.3 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain RNase_T PF00929.24 EFA76122.1 - 9.3e-11 42.5 0.0 2.9e-09 37.7 0.0 2.1 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EFA76122.1 - 0.028 14.1 1.1 0.12 12.1 1.1 1.9 1 1 0 1 1 1 0 3'-5' exonuclease Adeno_E1B_55K PF01696.17 EFA76122.1 - 0.061 12.0 1.1 0.09 11.4 1.1 1.2 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen DNase_II PF03265.15 EFA76125.1 - 9.3e-24 84.3 3.4 3.6e-13 49.5 0.5 3.5 3 1 0 3 3 3 2 Deoxyribonuclease II TIG PF01833.24 EFA76125.1 - 3e-18 65.7 38.5 1.2e-08 34.9 0.7 8.1 6 2 2 8 8 8 4 IPT/TIG domain SdrD_B PF17210.3 EFA76125.1 - 7.9e-06 26.1 0.2 3.8e-05 23.9 0.2 2.2 1 0 0 1 1 1 1 SdrD B-like domain TIG PF01833.24 EFA76127.1 - 1.7e-100 329.3 121.8 3.8e-15 55.7 1.7 18.4 18 1 1 19 19 19 12 IPT/TIG domain SdrD_B PF17210.3 EFA76127.1 - 1.7e-11 44.3 3.9 2.6e-08 34.1 0.1 7.1 7 0 0 7 7 7 2 SdrD B-like domain CBM49 PF09478.10 EFA76127.1 - 2.8e-08 33.9 17.6 2.8e-07 30.7 3.5 5.5 6 0 0 6 6 6 2 Carbohydrate binding domain CBM49 CarboxypepD_reg PF13620.6 EFA76127.1 - 3.1e-08 33.8 0.1 9.4e-06 25.8 0.0 5.4 5 0 0 5 5 5 2 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFA76127.1 - 0.00087 19.2 7.6 0.47 10.5 0.1 4.7 4 0 0 4 4 4 2 CarboxypepD_reg-like domain DUF2012 PF09430.10 EFA76127.1 - 0.0036 17.4 0.5 1.3 9.2 0.1 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2012) Y_Y_Y PF07495.13 EFA76127.1 - 0.022 14.7 8.7 0.072 13.1 0.2 4.4 3 1 0 3 3 3 0 Y_Y_Y domain CE2_N PF17996.1 EFA76127.1 - 0.13 12.2 0.9 1.6 8.7 0.2 3.3 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal tRNA-synt_2 PF00152.20 EFA76128.1 - 3.5e-79 266.1 0.1 4.3e-79 265.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFA76128.1 - 1.7e-09 37.5 0.1 3.3e-09 36.6 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFA76128.1 - 1.2e-08 34.8 0.1 0.00027 20.5 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) Glyco_hydro_38N PF01074.22 EFA76129.1 - 1.7e-44 152.4 0.7 1.7e-44 152.4 0.7 2.9 3 0 0 3 3 3 1 Glycosyl hydrolases family 38 N-terminal domain TTL PF03133.15 EFA76130.1 - 2.9e-65 220.3 6.1 7.2e-65 219.0 6.1 1.6 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFA76130.1 - 0.00012 21.4 0.7 0.01 15.1 0.0 2.7 3 0 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFA76130.1 - 0.00013 21.3 0.5 0.00065 19.0 0.1 2.3 2 1 1 3 3 3 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 EFA76130.1 - 0.0011 18.6 0.1 0.26 10.9 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFA76130.1 - 0.0056 16.2 0.0 0.28 10.7 0.0 2.5 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus MarR PF01047.22 EFA76130.1 - 0.11 12.4 0.1 0.3 11.0 0.1 1.7 1 0 0 1 1 1 0 MarR family Ank_2 PF12796.7 EFA76131.1 - 0.00022 21.7 0.8 0.00038 21.0 0.8 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) WD40 PF00400.32 EFA76132.1 - 2.8e-51 170.4 12.8 1.8e-08 34.9 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EFA76132.1 - 2e-24 86.3 0.2 4.1e-24 85.3 0.2 1.5 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EFA76132.1 - 1.2e-10 41.5 0.0 0.0041 17.4 0.0 4.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA76132.1 - 1.1e-06 27.6 2.0 0.18 10.4 0.9 3.5 2 1 0 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFA76132.1 - 1.3e-06 27.7 1.5 0.026 13.5 0.0 4.4 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFA76132.1 - 3e-06 26.8 1.1 0.0047 16.3 0.2 4.3 3 2 2 5 5 5 1 WD40-like domain LisH PF08513.11 EFA76132.1 - 0.00026 20.8 0.1 0.00064 19.6 0.1 1.7 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 EFA76132.1 - 0.0099 15.8 0.6 0.16 11.8 0.0 2.8 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A LRR_6 PF13516.6 EFA76133.1 - 3.7e-05 23.4 0.0 3.7e-05 23.4 0.0 5.5 6 0 0 6 6 6 2 Leucine Rich repeat F-box-like PF12937.7 EFA76133.1 - 0.017 15.0 0.1 0.079 12.9 0.1 2.2 1 1 0 1 1 1 0 F-box-like LRR_2 PF07723.13 EFA76133.1 - 0.04 14.6 2.3 6.6 7.6 0.2 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_1 PF00560.33 EFA76133.1 - 7.3 7.6 18.9 75 4.5 0.0 6.7 6 0 0 6 6 6 0 Leucine Rich Repeat ATXN-1_C PF12547.8 EFA76134.1 - 0.04 14.2 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 Capicua transcriptional repressor modulator ThiC-associated PF13667.6 EFA76134.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 ThiC-associated domain TIG PF01833.24 EFA76135.1 - 2.6e-97 319.0 125.9 9.5e-15 54.5 1.5 18.1 17 2 1 18 18 18 12 IPT/TIG domain SdrD_B PF17210.3 EFA76135.1 - 1.2e-11 44.9 5.0 7.9e-09 35.7 0.1 7.1 8 0 0 8 8 8 2 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA76135.1 - 9e-09 35.5 0.4 9.1e-06 25.9 0.0 5.5 5 0 0 5 5 5 2 Carboxypeptidase regulatory-like domain CBM49 PF09478.10 EFA76135.1 - 5e-07 29.9 4.1 5e-07 29.9 4.1 5.6 6 0 0 6 6 6 1 Carbohydrate binding domain CBM49 DUF2012 PF09430.10 EFA76135.1 - 0.001 19.2 0.6 0.34 11.0 0.2 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 EFA76135.1 - 0.0024 17.8 9.2 0.5 10.4 0.1 4.7 4 0 0 4 4 4 2 CarboxypepD_reg-like domain Y_Y_Y PF07495.13 EFA76135.1 - 0.018 15.0 10.2 0.071 13.1 0.2 4.3 3 1 0 3 3 3 0 Y_Y_Y domain CE2_N PF17996.1 EFA76135.1 - 0.15 12.1 1.1 1.6 8.7 0.2 3.2 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal DNase_II PF03265.15 EFA76136.1 - 2.6e-27 96.0 8.5 3.6e-17 62.7 5.6 3.4 3 0 0 3 3 3 2 Deoxyribonuclease II TIG PF01833.24 EFA76136.1 - 8.3e-17 61.1 56.9 2.7e-08 33.8 0.9 11.7 12 1 1 13 13 13 5 IPT/TIG domain SdrD_B PF17210.3 EFA76136.1 - 6.8e-05 23.1 0.2 6.8e-05 23.1 0.2 2.7 3 0 0 3 3 3 1 SdrD B-like domain TM2 PF05154.16 EFA76137.1 - 1.5e-05 25.3 2.6 2.3e-05 24.6 2.6 1.2 1 0 0 1 1 1 1 TM2 domain FIBP PF05427.11 EFA76138.1 - 5.7e-73 246.3 9.4 3.4e-59 201.0 3.8 2.0 2 0 0 2 2 2 2 Acidic fibroblast growth factor binding (FIBP) NUDE_C PF04880.13 EFA76138.1 - 9.4 6.7 15.3 39 4.7 15.3 2.0 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region zf-C3HC4_2 PF13923.6 EFA76139.1 - 5.4e-08 32.6 10.1 5.4e-08 32.6 10.1 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA76139.1 - 1.7e-07 31.4 11.8 1.7e-07 31.4 11.8 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA76139.1 - 2e-07 30.8 9.9 2e-07 30.8 9.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA76139.1 - 3.7e-07 29.9 6.0 3.7e-07 29.9 6.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PWI PF01480.17 EFA76139.1 - 7.9e-07 29.3 0.2 2.6e-06 27.7 0.2 1.9 1 0 0 1 1 1 1 PWI domain zf-rbx1 PF12678.7 EFA76139.1 - 6.6e-05 23.1 7.5 0.0002 21.6 7.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFA76139.1 - 0.0037 17.3 8.6 0.0045 17.0 6.5 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA76139.1 - 0.0041 17.0 8.6 0.0041 17.0 8.6 1.7 2 0 0 2 2 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EFA76139.1 - 0.008 16.2 1.7 0.018 15.1 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 EFA76139.1 - 0.04 13.8 0.2 2.7 7.9 0.0 2.8 2 0 0 2 2 2 0 Rad50 zinc hook motif Prok-RING_4 PF14447.6 EFA76139.1 - 0.061 13.2 11.3 3.5 7.5 11.5 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EFA76139.1 - 0.13 12.2 2.5 0.35 10.8 2.5 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFA76139.1 - 0.17 11.7 6.0 0.53 10.1 6.0 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FAM76 PF16046.5 EFA76139.1 - 1.2 8.4 13.3 0.08 12.3 1.6 2.6 2 1 0 2 2 2 0 FAM76 protein Mucin PF01456.17 EFA76139.1 - 1.2 9.1 26.7 0.8 9.7 6.7 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein zf-C3HC4_5 PF17121.5 EFA76139.1 - 1.3 9.0 5.9 8.4 6.4 2.8 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SSP160 PF06933.11 EFA76139.1 - 6.9 4.7 25.1 0.52 8.5 3.7 2.1 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 zf-RING_10 PF16685.5 EFA76139.1 - 8.8 6.5 8.5 1.2 9.4 4.2 1.8 2 0 0 2 2 1 0 zinc RING finger of MSL2 G-alpha PF00503.20 EFA76140.1 - 6.1e-118 394.0 3.1 7.5e-118 393.7 3.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA76140.1 - 1.1e-15 57.5 0.3 1.1e-11 44.6 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA76140.1 - 0.00033 20.1 0.3 0.12 11.7 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA76140.1 - 0.0068 16.6 0.2 3.6 7.8 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EFA76140.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FMN_dh PF01070.18 EFA76141.1 - 1.7e-136 454.9 0.0 1.9e-136 454.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EFA76141.1 - 4e-08 32.6 2.6 5.6e-07 28.9 0.8 2.7 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EFA76141.1 - 3e-07 30.1 0.3 4.9e-07 29.4 0.3 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EFA76141.1 - 2.2e-06 27.2 1.0 0.011 15.1 0.1 2.3 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EFA76141.1 - 0.00026 20.5 0.2 0.0085 15.5 0.1 2.4 1 1 1 2 2 2 1 Glycerol-3-phosphate responsive antiterminator DHO_dh PF01180.21 EFA76141.1 - 0.00028 20.2 0.1 0.0007 18.9 0.0 1.7 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Dus PF01207.17 EFA76141.1 - 0.00035 19.8 0.0 0.0011 18.1 0.0 1.8 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EFA76141.1 - 0.0018 17.8 0.3 0.028 13.9 0.0 2.5 1 1 1 2 2 2 1 Histidine biosynthesis protein Glu_synthase PF01645.17 EFA76141.1 - 0.0029 16.8 0.2 0.006 15.8 0.2 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase DUF658 PF04936.12 EFA76141.1 - 0.048 13.4 0.1 0.098 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF658) TMP-TENI PF02581.17 EFA76141.1 - 0.14 11.5 0.1 3.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Thiamine monophosphate synthase VID27 PF08553.10 EFA76142.1 - 1.8e-78 264.1 3.3 8.4e-76 255.3 3.3 3.0 1 1 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EFA76142.1 - 1.9e-11 44.1 0.2 1.9e-11 44.1 0.2 4.7 3 1 1 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 EFA76142.1 - 9.3e-06 25.9 1.4 9.3e-06 25.9 1.4 3.1 3 0 0 3 3 3 1 VID27 PH-like domain CENP-F_leu_zip PF10473.9 EFA76143.1 - 0.0015 18.6 1.6 0.0018 18.3 1.6 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 EFA76143.1 - 0.0052 17.2 1.4 0.016 15.6 0.8 2.1 2 1 1 3 3 3 2 Flagella accessory protein C (FlaC) DUF5082 PF16888.5 EFA76143.1 - 0.017 15.4 1.6 0.031 14.5 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Nsp1_C PF05064.13 EFA76143.1 - 0.019 14.7 1.0 0.059 13.2 0.8 1.7 1 1 1 2 2 2 0 Nsp1-like C-terminal region XhlA PF10779.9 EFA76143.1 - 0.29 11.4 1.7 0.56 10.5 1.7 1.5 1 1 0 1 1 1 0 Haemolysin XhlA DUF202 PF02656.15 EFA76144.1 - 0.0065 16.9 1.6 0.03 14.7 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF202) SirB PF04247.12 EFA76144.1 - 0.0077 16.3 0.2 0.0096 16.0 0.2 1.1 1 0 0 1 1 1 1 Invasion gene expression up-regulator, SirB Acyl_transf_3 PF01757.22 EFA76144.1 - 0.0084 15.2 0.8 0.01 15.0 0.8 1.1 1 0 0 1 1 1 1 Acyltransferase family Pox_EPC_I2-L1 PF12575.8 EFA76144.1 - 0.22 11.8 1.2 0.43 10.8 0.0 1.9 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 EssA PF10661.9 EFA76144.1 - 0.89 9.4 2.0 1.2 9.0 0.1 1.8 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA DUF3149 PF11346.8 EFA76144.1 - 1.9 8.1 5.1 0.88 9.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) DUF2375 PF09558.10 EFA76145.1 - 0.1 12.7 0.1 26 4.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2375) BRCT_2 PF16589.5 EFA76146.1 - 5.6e-06 26.7 0.1 1e-05 25.8 0.1 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain WWE PF02825.20 EFA76146.1 - 0.00019 21.9 0.2 0.00052 20.5 0.2 1.8 1 0 0 1 1 1 1 WWE domain XRN_N PF03159.18 EFA76147.1 - 8.5e-68 228.4 0.0 2.8e-67 226.7 0.0 2.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFA76147.1 - 1.8e-58 198.5 1.8 1.1e-41 143.2 0.6 4.5 5 1 1 6 6 6 2 Xrn1 helical domain PITH PF06201.13 EFA76147.1 - 6.2e-17 62.2 7.3 6.2e-17 62.2 7.3 3.4 3 0 0 3 3 3 1 PITH domain RRM_1 PF00076.22 EFA76147.1 - 7.2e-16 57.8 0.2 1.3e-07 31.3 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UBA_4 PF14555.6 EFA76147.1 - 0.0027 17.5 0.1 0.011 15.5 0.1 2.1 1 0 0 1 1 1 1 UBA-like domain zf-CCHC_3 PF13917.6 EFA76147.1 - 0.098 12.6 4.9 0.071 13.1 2.4 2.0 2 0 0 2 2 2 0 Zinc knuckle Coiled PF05710.12 EFA76148.1 - 0.0038 18.0 5.1 0.0043 17.8 5.1 1.2 1 1 0 1 1 1 1 Coiled coil GvpG PF05120.12 EFA76150.1 - 0.2 11.7 0.0 0.53 10.3 0.0 1.6 2 0 0 2 2 2 0 Gas vesicle protein G VirE1 PF12189.8 EFA76151.1 - 0.048 13.8 0.2 0.049 13.7 0.2 1.1 1 0 0 1 1 1 0 Single-strand DNA-binding protein RVT_1 PF00078.27 EFA76153.1 - 2.1e-27 96.1 0.3 9.6e-27 93.9 0.1 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RimK PF08443.11 EFA76154.1 - 1.5e-08 34.4 0.0 1e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 RimK-like ATP-grasp domain PPIP5K2_N PF18086.1 EFA76154.1 - 1.9e-05 24.7 2.6 0.074 13.2 0.0 3.6 2 1 1 3 3 3 3 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain EMC3_TMCO1 PF01956.16 EFA76155.1 - 0.064 13.0 0.6 0.1 12.3 0.6 1.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Auts2 PF15336.6 EFA76155.1 - 0.34 11.0 10.7 0.65 10.1 10.7 1.4 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein SOBP PF15279.6 EFA76155.1 - 2.2 8.8 7.7 2.7 8.5 7.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 EFA76155.1 - 3.7 6.1 5.1 4.2 5.9 5.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LMBR1 PF04791.16 EFA76155.1 - 4.3 6.1 4.8 4.3 6.1 4.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PA26 PF04636.13 EFA76155.1 - 4.3 6.1 10.6 5.2 5.9 10.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Utp12 PF04003.12 EFA76156.1 - 1e-25 90.1 0.0 1.2e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Dip2/Utp12 Family Utp21 PF04192.12 EFA76156.1 - 0.00023 20.7 0.3 0.00023 20.7 0.3 2.1 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain NOA36 PF06524.12 EFA76156.1 - 0.0054 16.1 6.3 0.0072 15.7 6.3 1.1 1 0 0 1 1 1 1 NOA36 protein Ferritin PF00210.24 EFA76156.1 - 0.007 16.3 0.0 0.007 16.3 0.0 1.6 2 0 0 2 2 2 1 Ferritin-like domain RNA_pol_RpbG PF16992.5 EFA76156.1 - 0.05 13.7 2.4 0.063 13.3 1.4 1.6 1 1 1 2 2 2 0 DNA-directed RNA polymerase, subunit G CDC45 PF02724.14 EFA76156.1 - 0.87 7.8 9.0 0.94 7.7 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein NESP55 PF06390.12 EFA76156.1 - 4.6 6.8 11.8 6.1 6.4 11.8 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) WD40 PF00400.32 EFA76157.1 - 2.6e-36 123.0 4.8 3.8e-10 40.2 0.5 10.2 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76157.1 - 1.9e-24 85.7 0.0 0.00061 20.0 0.0 8.1 4 3 4 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA76157.1 - 2.2e-08 33.5 0.3 0.018 14.0 0.0 5.5 3 1 4 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFA76157.1 - 1.7e-07 31.0 3.0 7.5 6.6 0.0 7.5 8 0 0 8 8 8 3 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EFA76157.1 - 7.3e-06 26.0 0.2 0.27 11.1 0.1 5.0 3 1 2 5 5 5 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFA76157.1 - 0.0002 20.8 0.1 0.028 13.8 0.0 4.0 3 2 1 4 4 4 1 WD40-like domain Nup160 PF11715.8 EFA76157.1 - 0.00071 18.3 0.3 0.03 13.0 0.0 2.5 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 EFA76157.1 - 0.004 16.5 0.4 28 3.9 0.0 4.6 5 0 0 5 5 5 0 Neuroblastoma-amplified sequence, N terminal DUF1513 PF07433.11 EFA76157.1 - 0.014 14.5 0.1 1.2 8.2 0.0 3.6 3 2 2 5 5 5 0 Protein of unknown function (DUF1513) PQQ_3 PF13570.6 EFA76157.1 - 4.2 8.0 11.2 2.6 8.6 0.1 5.1 5 1 1 6 6 6 0 PQQ-like domain Glyco_hydro_25 PF01183.20 EFA76158.1 - 4.8e-05 23.6 0.4 6.3e-05 23.2 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Glyco_hydro_25 PF01183.20 EFA76159.1 - 1.1e-05 25.8 2.2 1.5e-05 25.2 2.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 MafB19-deam PF14437.6 EFA76159.1 - 0.025 14.3 0.1 0.043 13.6 0.1 1.3 1 0 0 1 1 1 0 MafB19-like deaminase zf-C4pol PF14260.6 EFA76159.1 - 0.099 13.1 0.1 0.21 12.1 0.1 1.5 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta SelR PF01641.18 EFA76160.1 - 0.0021 18.1 0.7 0.0048 17.0 0.7 1.7 1 0 0 1 1 1 1 SelR domain Dicty_REP PF05086.12 EFA76160.1 - 0.0039 15.2 9.0 0.0046 15.0 9.0 1.0 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein DUF908 PF06012.12 EFA76160.1 - 0.48 9.8 5.6 0.55 9.6 5.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SCIMP PF15050.6 EFA76160.1 - 1 9.8 3.6 1.1 9.8 2.3 1.8 1 1 0 1 1 1 0 SCIMP protein DUF647 PF04884.14 EFA76161.1 - 2.4e-94 315.5 2.0 3.1e-94 315.1 2.0 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis PA14 PF07691.12 EFA76162.1 - 2.1e-09 37.3 0.0 4.5e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 PA14 domain Dicty_CTDC PF00526.18 EFA76162.1 - 3e-06 27.0 39.5 0.00047 20.0 7.4 14.3 15 0 0 15 15 15 9 Dictyostelium (slime mold) repeat FNIP PF05725.12 EFA76164.1 - 3.2e-36 123.2 35.1 3.2e-09 36.8 0.0 8.3 6 2 1 7 7 7 6 FNIP Repeat PARP PF00644.20 EFA76165.1 - 2.1e-29 102.5 0.5 1.4e-28 99.8 0.5 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFA76165.1 - 7.3e-10 39.1 0.7 7.3e-10 39.1 0.7 1.8 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain BRCT_2 PF16589.5 EFA76165.1 - 1.2e-07 32.0 0.9 7.6e-07 29.5 0.2 2.6 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA76165.1 - 1.1e-05 25.7 0.3 5e-05 23.6 0.2 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain WGR PF05406.15 EFA76165.1 - 0.0045 17.0 0.4 0.011 15.7 0.4 1.6 1 0 0 1 1 1 1 WGR domain RPN2_C PF18004.1 EFA76166.1 - 5.5e-47 159.7 14.1 5.5e-47 159.7 14.1 2.0 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EFA76166.1 - 3.6e-39 131.2 28.9 4.4e-08 33.2 0.3 9.3 9 0 0 9 9 9 8 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFA76166.1 - 2.2e-14 53.6 0.1 4.1e-09 36.7 0.0 3.4 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 EFA76166.1 - 0.0052 16.9 0.1 4.1 7.9 0.0 4.3 4 0 0 4 4 4 1 HEAT repeat Clathrin_H_link PF13838.6 EFA76166.1 - 0.079 12.9 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 Clathrin-H-link 14-3-3 PF00244.20 EFA76166.1 - 0.23 10.9 9.6 0.62 9.5 9.6 1.6 1 0 0 1 1 1 0 14-3-3 protein DUF2228 PF10228.9 EFA76166.1 - 0.84 9.3 8.0 8.7 6.0 0.0 2.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) RR_TM4-6 PF06459.12 EFA76166.1 - 1 9.2 10.8 2.2 8.1 10.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SMYLE_N PF18615.1 EFA76166.1 - 2.1 7.8 11.7 0.52 9.8 8.1 1.7 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Ribosomal_60s PF00428.19 EFA76166.1 - 3.7 8.2 15.9 14 6.4 9.5 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Presenilin PF01080.17 EFA76166.1 - 5.2 5.7 6.0 9.5 4.9 6.0 1.4 1 0 0 1 1 1 0 Presenilin CBS PF00571.28 EFA76167.1 - 1.2e-27 96.1 3.3 8.8e-10 38.9 0.0 4.2 4 0 0 4 4 4 3 CBS domain FTCD_N PF07837.12 EFA76168.1 - 6.8e-72 240.9 0.0 1.1e-71 240.2 0.0 1.4 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.14 EFA76168.1 - 2.8e-68 228.5 0.0 5.6e-68 227.5 0.0 1.5 1 0 0 1 1 1 1 Formiminotransferase domain FTCD_C PF04961.12 EFA76168.1 - 1.1e-67 227.4 0.2 1.7e-67 226.7 0.2 1.3 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase PheRS_DBD2 PF18554.1 EFA76168.1 - 0.052 13.5 0.3 0.19 11.8 0.3 2.0 1 0 0 1 1 1 0 PheRS DNA binding domain 2 PocR PF10114.9 EFA76168.1 - 0.09 12.6 0.1 0.55 10.0 0.0 2.2 2 0 0 2 2 2 0 Sensory domain found in PocR Ras PF00071.22 EFA76170.1 - 8.2e-61 204.3 0.1 1.1e-43 148.6 0.0 2.6 3 0 0 3 3 3 2 Ras family Roc PF08477.13 EFA76170.1 - 1e-29 103.2 0.0 1.7e-20 73.5 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA76170.1 - 1.2e-05 24.8 0.0 3.6e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family LysM PF01476.20 EFA76170.1 - 4.3e-05 23.5 0.1 0.00012 22.0 0.1 1.8 1 0 0 1 1 1 1 LysM domain AAA_24 PF13479.6 EFA76170.1 - 0.04 13.7 0.0 0.43 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain SR-25 PF10500.9 EFA76170.1 - 3 7.4 6.7 5.6 6.5 6.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RRP36 PF06102.12 EFA76171.1 - 6.7e-45 153.0 26.6 6.7e-45 153.0 26.6 2.5 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 PPR_3 PF13812.6 EFA76174.1 - 0.0018 18.3 0.5 0.025 14.7 0.1 2.7 2 0 0 2 2 2 1 Pentatricopeptide repeat domain DUF4373 PF14297.6 EFA76174.1 - 0.24 12.2 3.2 0.23 12.3 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) Beta_helix PF13229.6 EFA76175.1 - 7.1e-17 61.7 23.2 7.1e-17 61.7 23.2 4.3 2 1 2 4 4 4 3 Right handed beta helix region NosD PF05048.13 EFA76175.1 - 2e-08 33.8 31.2 2.3e-08 33.6 3.8 4.5 1 1 1 3 3 3 3 Periplasmic copper-binding protein (NosD) EF-G-binding_N PF07299.11 EFA76176.1 - 0.015 15.8 0.2 0.019 15.5 0.2 1.0 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal EMC3_TMCO1 PF01956.16 EFA76177.1 - 4.2e-51 173.1 1.8 5.5e-51 172.7 1.8 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like GST_N_3 PF13417.6 EFA76178.1 - 2.3e-33 114.4 0.6 1.2e-15 57.7 0.1 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFA76178.1 - 9.5e-33 112.4 0.3 7e-16 58.3 0.1 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA76178.1 - 1.2e-30 105.6 0.1 8.9e-15 54.7 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA76178.1 - 9.9e-17 61.0 0.0 1.3e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EFA76178.1 - 4.6e-08 33.1 0.0 0.0087 16.3 0.0 2.6 2 0 0 2 2 2 2 Glutaredoxin GST_C PF00043.25 EFA76178.1 - 2.8e-06 27.5 0.0 0.084 13.1 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA76178.1 - 3.2e-06 27.1 0.0 0.077 13.0 0.0 2.8 3 0 0 3 3 3 2 Glutathione S-transferase, C-terminal domain DUF4032 PF13224.6 EFA76178.1 - 0.0073 16.2 0.1 0.99 9.3 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4032) NUC153 PF08159.12 EFA76178.1 - 0.0079 16.0 8.1 0.58 10.0 0.3 4.4 4 0 0 4 4 4 1 NUC153 domain HAD_SAK_2 PF18143.1 EFA76178.1 - 0.016 15.5 0.1 2.5 8.4 0.0 3.1 3 1 1 4 4 4 0 HAD domain in Swiss Army Knife RNA repair proteins Thioredoxin_3 PF13192.6 EFA76178.1 - 0.035 14.2 0.0 9.2 6.4 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin domain DNA_pol_lambd_f PF10391.9 EFA76178.1 - 0.14 12.0 0.1 16 5.4 0.0 2.8 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda MBOAT PF03062.19 EFA76179.1 - 1.2e-15 57.7 21.8 1.2e-15 57.7 21.8 1.6 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Lipocalin_2 PF08212.12 EFA76180.1 - 0.033 14.1 0.0 1.2 9.0 0.0 2.0 2 0 0 2 2 2 0 Lipocalin-like domain DUF885 PF05960.11 EFA76182.1 - 2.6e-102 344.2 0.0 3.3e-102 343.8 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) Get5_C PF18514.1 EFA76182.1 - 0.13 12.0 0.3 20 5.0 0.0 3.2 3 0 0 3 3 3 0 Get5 C-terminal domain Bromodomain PF00439.25 EFA76183.1 - 0.044 13.8 0.5 0.4 10.8 0.0 2.3 2 0 0 2 2 2 0 Bromodomain PepSY PF03413.19 EFA76183.1 - 0.18 12.4 1.6 17 6.1 0.4 3.5 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain JAB PF01398.21 EFA76184.1 - 3e-29 101.4 0.0 7.7e-29 100.1 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFA76184.1 - 6.3e-28 97.4 1.8 1.1e-27 96.7 1.8 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function DUF3450 PF11932.8 EFA76184.1 - 0.042 13.2 0.1 0.066 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FlxA PF14282.6 EFA76184.1 - 1.4 8.9 6.1 0.23 11.4 0.4 2.2 2 0 0 2 2 2 0 FlxA-like protein PTPLA PF04387.14 EFA76185.1 - 1.4e-47 161.5 11.9 2.1e-47 160.9 11.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA ATP-synt_8 PF00895.20 EFA76185.1 - 1.1 9.8 6.0 9.3 6.8 0.6 2.7 2 0 0 2 2 2 0 ATP synthase protein 8 GSHPx PF00255.19 EFA76186.1 - 1.2e-17 63.5 0.0 4e-17 61.7 0.0 1.8 1 1 1 2 2 2 2 Glutathione peroxidase GSHPx PF00255.19 EFA76187.1 - 4.7e-17 61.5 0.1 6.8e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione peroxidase Dynamin_N PF00350.23 EFA76188.1 - 3.1e-37 128.2 0.0 3.1e-37 128.2 0.0 2.7 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EFA76188.1 - 9.2e-06 25.7 0.4 5.5e-05 23.2 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase HSP70 PF00012.20 EFA76188.1 - 0.16 10.1 6.1 0.3 9.2 6.1 1.4 1 0 0 1 1 1 0 Hsp70 protein Nod1 PF17114.5 EFA76188.1 - 3.3 7.9 7.0 7.9 6.6 0.3 3.0 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 Rep_fac-A_C PF08646.10 EFA76189.1 - 0.049 13.4 1.1 0.11 12.2 1.1 1.7 1 0 0 1 1 1 0 Replication factor-A C terminal domain HscB_4_cys PF18256.1 EFA76189.1 - 0.086 12.7 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif Ank_2 PF12796.7 EFA76191.1 - 1.2e-25 89.9 4.5 2.6e-07 31.1 0.1 6.4 4 1 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76191.1 - 7.6e-23 80.6 7.6 0.00026 21.5 0.0 9.0 8 1 1 9 9 9 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76191.1 - 2e-14 53.4 6.5 1.5 9.2 0.0 9.6 5 1 5 10 10 10 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76191.1 - 2.1e-14 52.2 4.4 20 6.2 0.0 12.1 12 0 0 12 12 12 2 Ankyrin repeat DUF249 PF03158.13 EFA76191.1 - 7.2e-08 32.4 4.3 0.0011 18.7 0.0 5.3 2 1 2 5 5 5 2 Multigene family 530 protein Ank PF00023.30 EFA76191.1 - 0.094 13.2 1.4 2.6e+02 2.3 0.0 5.6 5 1 0 5 5 5 0 Ankyrin repeat EP400_N PF15790.5 EFA76191.1 - 0.35 9.7 0.3 2.2 7.1 0.1 1.9 2 0 0 2 2 2 0 E1A-binding protein p400, N-terminal 2-oxoacid_dh PF00198.23 EFA76192.1 - 4e-78 262.1 0.0 6.6e-78 261.3 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFA76192.1 - 3.5e-37 126.1 4.6 4.8e-18 64.8 0.7 2.4 2 0 0 2 2 2 2 Biotin-requiring enzyme E3_binding PF02817.17 EFA76192.1 - 1.2e-13 51.2 0.0 3e-13 49.9 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EFA76192.1 - 5.9e-10 38.8 0.5 0.00059 19.6 0.1 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like PYNP_C PF07831.13 EFA76192.1 - 4.5e-05 23.0 0.4 0.37 10.5 0.1 2.7 2 0 0 2 2 2 2 Pyrimidine nucleoside phosphorylase C-terminal domain RnfC_N PF13375.6 EFA76192.1 - 0.013 15.5 0.2 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 EFA76192.1 - 0.017 15.0 0.3 6.5 6.7 0.1 2.5 2 0 0 2 2 2 0 Glycine cleavage H-protein HlyD_3 PF13437.6 EFA76192.1 - 0.023 15.4 0.0 4.7 8.0 0.0 2.7 2 0 0 2 2 2 0 HlyD family secretion protein ATP-synt_ab_Xtn PF16886.5 EFA76192.1 - 0.023 14.5 0.4 5.4 6.9 0.0 3.0 3 0 0 3 3 3 0 ATPsynthase alpha/beta subunit N-term extension Peptidase_M23 PF01551.22 EFA76192.1 - 0.028 14.6 0.1 4.3 7.6 0.0 2.6 2 0 0 2 2 2 0 Peptidase family M23 DUF515 PF04415.12 EFA76192.1 - 0.083 11.3 2.0 0.96 7.8 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF515) TIG PF01833.24 EFA76193.1 - 5e-13 48.9 60.0 1.6e-09 37.7 3.4 7.6 6 1 1 7 7 7 4 IPT/TIG domain EGF_2 PF07974.13 EFA76193.1 - 5.1e-08 33.2 32.7 0.00068 20.0 13.2 2.7 2 0 0 2 2 2 2 EGF-like domain EGF_Tenascin PF18720.1 EFA76193.1 - 0.02 15.0 27.8 0.088 12.9 11.6 2.7 2 0 0 2 2 2 0 Tenascin EGF domain EGF PF00008.27 EFA76193.1 - 0.3 11.4 26.3 0.28 11.5 7.9 2.7 2 0 0 2 2 2 0 EGF-like domain RSV_NS2 PF03113.14 EFA76193.1 - 0.72 9.9 4.5 0.74 9.8 0.1 2.9 3 0 0 3 3 3 0 Respiratory synctial virus non-structural protein NS2 Laminin_EGF PF00053.24 EFA76193.1 - 3.5 7.9 20.7 0.45 10.7 7.3 2.5 2 0 0 2 2 2 0 Laminin EGF domain FNIP PF05725.12 EFA76194.1 - 2.2e-28 98.1 29.8 1.7e-09 37.7 0.0 8.1 6 1 2 8 8 8 8 FNIP Repeat F-box_5 PF18511.1 EFA76194.1 - 0.015 14.8 0.7 0.03 13.9 0.7 1.4 1 0 0 1 1 1 0 F-box FNIP PF05725.12 EFA76195.1 - 4.1e-19 68.5 20.6 0.00021 21.4 0.4 8.3 7 2 0 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA76195.1 - 0.00029 20.4 0.3 0.00072 19.1 0.3 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA76195.1 - 0.02 14.8 2.0 0.054 13.4 2.0 1.7 1 0 0 1 1 1 0 F-box-like LRR_6 PF13516.6 EFA76195.1 - 0.049 13.7 2.0 19 5.7 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 EFA76195.1 - 0.62 10.8 9.6 24 6.0 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat FGGY_N PF00370.21 EFA76196.1 - 1.7e-45 155.5 0.5 3.2e-44 151.3 0.5 2.1 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EFA76196.1 - 1.7e-36 125.9 0.1 4.5e-35 121.2 0.0 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain NLRC4_HD PF17889.1 EFA76196.1 - 0.12 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 NLRC4 helical domain Sulfate_transp PF00916.20 EFA76197.1 - 1.6e-102 343.1 21.1 2.3e-102 342.6 21.1 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFA76197.1 - 7.6e-21 73.9 0.0 1.5e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFA76197.1 - 0.3 11.5 9.1 0.039 14.3 4.0 2.3 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily WD40 PF00400.32 EFA76198.1 - 9.2e-24 83.3 29.1 0.00021 22.0 0.0 7.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76198.1 - 1.7e-06 28.2 0.2 0.42 10.9 0.0 4.4 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1149 PF06619.11 EFA76198.1 - 0.036 14.3 2.8 0.13 12.6 2.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1149) RRM_1 PF00076.22 EFA76199.1 - 2.1e-74 245.3 1.5 9.6e-18 63.8 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA76199.1 - 1e-06 28.5 0.0 0.46 10.4 0.0 4.5 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EFA76199.1 - 1.8e-06 28.0 0.0 17 5.6 0.0 5.8 5 0 0 5 5 5 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EFA76199.1 - 6.2e-06 26.1 0.0 0.33 11.0 0.0 3.8 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_2 PF04059.12 EFA76199.1 - 0.062 13.5 0.3 25 5.1 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif 2 Dicty_CTDC PF00526.18 EFA76201.1 - 6.8e-33 112.2 87.9 4e-09 36.2 11.7 6.1 6 0 0 6 6 6 6 Dictyostelium (slime mold) repeat MOSC_N PF03476.16 EFA76202.1 - 0.029 14.3 1.8 0.034 14.0 0.1 2.0 2 0 0 2 2 2 0 MOSC N-terminal beta barrel domain Dapper PF15268.6 EFA76204.1 - 0.0025 16.8 48.3 0.0035 16.3 48.3 1.4 1 0 0 1 1 1 1 Dapper DUF4045 PF13254.6 EFA76204.1 - 0.16 11.5 41.4 0.25 11.0 41.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) RasGEF PF00617.19 EFA76205.1 - 8e-57 192.3 1.0 8e-57 192.3 1.0 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFA76205.1 - 1.5e-20 73.3 0.4 1.5e-20 73.3 0.4 4.1 3 2 0 3 3 3 1 RasGEF N-terminal motif tRNA-Thr_ED PF08915.11 EFA76205.1 - 0.4 10.8 9.0 3.4 7.7 2.2 3.2 2 0 0 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase LIP PF03583.14 EFA76205.1 - 1.5 8.1 3.8 0.9 8.8 0.5 2.2 2 0 0 2 2 2 0 Secretory lipase ZYG-11_interact PF05884.12 EFA76205.1 - 7 6.0 8.1 3.4 7.0 0.5 2.7 2 0 0 2 2 2 0 Interactor of ZYG-11 SnoaL_2 PF12680.7 EFA76207.1 - 1.6e-08 35.1 0.0 1.9e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFA76207.1 - 0.012 15.9 0.0 0.016 15.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) PPL5 PF18168.1 EFA76208.1 - 0.12 11.7 3.0 0.17 11.2 3.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 ASD2 PF08687.11 EFA76208.1 - 0.13 11.8 13.2 4.6 6.7 0.1 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Utp11 PF03998.13 EFA76208.1 - 0.16 11.8 4.2 0.25 11.3 4.2 1.2 1 0 0 1 1 1 0 Utp11 protein POX PF07526.11 EFA76208.1 - 0.58 10.7 7.4 0.12 13.0 3.3 1.8 2 0 0 2 2 2 0 Associated with HOX SSP160 PF06933.11 EFA76208.1 - 1.4 7.0 32.5 1.9 6.6 14.6 2.1 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 MID_MedPIWI PF18296.1 EFA76208.1 - 2.3 7.9 11.0 0.22 11.3 4.1 2.0 2 0 0 2 2 2 0 MID domain of medPIWI Thiolase_N PF00108.23 EFA76209.1 - 5.3e-83 278.4 3.4 7.1e-83 277.9 3.4 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFA76209.1 - 1.2e-48 163.9 0.8 2.8e-48 162.6 0.8 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFA76209.1 - 0.0011 18.6 0.4 0.0028 17.3 0.2 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EFA76209.1 - 0.014 15.2 0.9 1.7 8.6 0.2 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III BcrAD_BadFG PF01869.20 EFA76209.1 - 0.025 14.1 0.3 0.045 13.3 0.3 1.5 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family CopK PF11525.8 EFA76209.1 - 0.11 12.1 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Copper resistance protein K Myosin_N PF02736.19 EFA76209.1 - 0.17 11.8 1.4 0.31 10.9 1.4 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Hat1_N PF10394.9 EFA76210.1 - 4.2e-43 147.3 2.8 6.2e-43 146.8 1.4 2.0 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EFA76210.1 - 2.7e-05 24.4 0.0 6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 EFA76210.1 - 0.003 17.2 0.2 0.0058 16.3 0.2 1.7 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 EFA76210.1 - 0.0071 16.8 0.0 0.02 15.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA76210.1 - 0.028 14.4 0.0 0.073 13.0 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HlyIII PF03006.20 EFA76211.1 - 5.7e-29 101.4 18.3 1.1e-23 84.2 7.6 2.2 1 1 1 2 2 2 2 Haemolysin-III related Ceramidase PF05875.12 EFA76211.1 - 0.00059 19.4 4.5 0.14 11.6 0.2 2.2 2 0 0 2 2 2 2 Ceramidase RWP-RK PF02042.15 EFA76212.1 - 1.2e-23 82.8 0.4 2.9e-23 81.6 0.1 1.9 2 0 0 2 2 2 1 RWP-RK domain TMEM215 PF15746.5 EFA76212.1 - 0.064 12.7 0.3 4.2 6.8 0.1 2.2 2 0 0 2 2 2 0 TMEM215 family HlyD_2 PF12700.7 EFA76212.1 - 0.075 11.8 7.7 0.12 11.1 7.7 1.2 1 0 0 1 1 1 0 HlyD family secretion protein MAPKK1_Int PF08923.10 EFA76214.1 - 5e-32 110.2 0.9 5.4e-32 110.1 0.9 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting SpoVT_C PF15714.5 EFA76214.1 - 0.0067 16.5 0.0 0.0072 16.4 0.0 1.1 1 0 0 1 1 1 1 Stage V sporulation protein T C-terminal, transcription factor PBP1_TM PF14812.6 EFA76215.1 - 0.002 18.5 1.4 0.002 18.5 1.4 3.1 2 1 1 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Dicty_CAR PF05462.11 EFA76215.1 - 0.26 10.4 0.1 0.26 10.4 0.1 1.7 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor NAT PF04768.13 EFA76216.1 - 3.2e-35 121.3 0.0 7.4e-35 120.1 0.0 1.6 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 EFA76216.1 - 1e-06 28.5 0.0 2.5e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 Amino acid kinase family Zip PF02535.22 EFA76216.1 - 0.00013 21.3 0.8 0.00013 21.3 0.8 2.2 1 1 1 2 2 2 1 ZIP Zinc transporter Wbp11 PF09429.10 EFA76216.1 - 0.034 14.5 15.4 0.032 14.6 12.4 2.6 2 1 1 3 3 3 0 WW domain binding protein 11 DUF4834 PF16118.5 EFA76216.1 - 1.9 9.5 10.4 3.8 8.5 0.6 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) GATase_7 PF13537.6 EFA76218.1 - 2.9e-11 43.3 0.0 6.7e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFA76218.1 - 1.2e-10 41.7 0.0 3.3e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EFA76218.1 - 4.2e-07 29.6 0.0 7.8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EFA76218.1 - 0.095 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II PRTase_2 PF15609.6 EFA76218.1 - 0.1 12.1 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosyl transferase zf-CCHC_4 PF14392.6 EFA76219.1 - 0.039 13.7 1.3 0.039 13.7 1.3 1.6 2 0 0 2 2 2 0 Zinc knuckle RasGAP PF00616.19 EFA76220.1 - 2.6e-29 102.4 0.0 3.9e-18 65.9 0.1 2.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase DUF547 PF04784.14 EFA76220.1 - 4.8e-09 36.3 0.0 1.6e-08 34.6 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF547 MutS_V PF00488.21 EFA76223.1 - 3.5e-61 206.5 0.3 8e-61 205.4 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFA76223.1 - 8.8e-24 84.8 1.4 8.8e-24 84.8 1.4 1.9 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EFA76223.1 - 7.4e-10 39.1 4.7 1.4e-09 38.1 0.0 3.6 4 0 0 4 4 4 1 MutS family domain IV MutS_II PF05188.17 EFA76223.1 - 2.3e-05 24.7 0.0 8.8e-05 22.8 0.0 2.0 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 EFA76223.1 - 0.027 14.1 0.1 0.16 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EFA76223.1 - 0.038 13.2 0.2 0.13 11.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FDF PF09532.10 EFA76223.1 - 8.6 7.3 13.1 0.12 13.3 4.7 2.2 3 0 0 3 3 3 0 FDF domain zf-met PF12874.7 EFA76224.1 - 2.8e-06 27.5 10.4 0.00017 21.8 0.1 3.8 3 1 1 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFA76224.1 - 0.00018 21.8 1.6 0.00018 21.8 1.6 1.9 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFA76224.1 - 0.21 11.9 0.3 0.21 11.9 0.3 3.8 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EFA76224.1 - 1.2 9.7 9.9 0.7 10.5 0.9 3.6 4 1 0 4 4 4 0 Zinc finger, C2H2 type GpcrRhopsn4 PF10192.9 EFA76225.1 - 2.3e-14 53.4 13.4 2.9e-14 53.1 13.4 1.1 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain DUF4834 PF16118.5 EFA76225.1 - 0.01 16.8 1.9 0.01 16.8 1.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2615 PF11027.8 EFA76225.1 - 0.017 15.3 10.5 1.1 9.4 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) Menin PF05053.13 EFA76225.1 - 0.022 13.2 4.5 0.026 12.9 4.5 1.2 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 EFA76225.1 - 0.043 14.3 16.5 0.066 13.8 16.5 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3328 PF11807.8 EFA76225.1 - 0.96 9.2 9.2 0.085 12.6 1.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3328) DUF2569 PF10754.9 EFA76225.1 - 1 9.8 13.6 2.3 8.7 11.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) Sdh_cyt PF01127.22 EFA76225.1 - 2.8 8.0 7.3 3.6 7.6 5.9 1.8 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Yip1 PF04893.17 EFA76228.1 - 1.9e-08 34.2 9.3 2.4e-08 33.9 9.3 1.2 1 0 0 1 1 1 1 Yip1 domain TMEM252 PF15664.5 EFA76228.1 - 1.7 8.4 7.3 0.74 9.5 1.2 2.6 1 1 1 2 2 2 0 Transmembrane protein 252 family Acyl-CoA_dh_N PF02771.16 EFA76229.1 - 5.3e-24 85.0 0.0 1.2e-23 83.9 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFA76229.1 - 1.5e-21 76.4 0.0 2.5e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFA76229.1 - 1.2e-11 45.0 0.7 2.3e-08 34.4 0.1 2.3 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Pkinase PF00069.25 EFA76230.1 - 2.3e-40 138.6 0.0 7.4e-34 117.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76230.1 - 5.4e-29 101.3 0.0 8.8e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Acetyltransf_1 PF00583.25 EFA76230.1 - 0.0015 18.8 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Pkinase_fungal PF17667.1 EFA76230.1 - 0.0027 16.5 0.0 0.0045 15.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Acetyltransf_10 PF13673.7 EFA76230.1 - 0.04 13.9 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain APH PF01636.23 EFA76230.1 - 0.045 13.7 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFA76230.1 - 0.16 11.3 0.0 0.33 10.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.29 EFA76231.1 - 9.6e-41 139.3 0.5 4.7e-40 137.1 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFA76231.1 - 3.4e-16 59.0 0.2 6.7e-16 58.0 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFA76231.1 - 7.1e-12 44.9 0.1 2e-11 43.5 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFA76231.1 - 2.3e-06 27.6 0.5 1.4e-05 25.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA76231.1 - 6.3e-06 26.7 0.1 0.0077 16.6 0.0 2.4 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 EFA76231.1 - 7.5e-05 22.9 0.0 0.0004 20.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFA76231.1 - 0.00018 21.3 0.0 0.00048 19.9 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFA76231.1 - 0.00053 20.3 0.3 0.077 13.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain PhoH PF02562.16 EFA76231.1 - 0.002 17.6 0.0 0.018 14.5 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_33 PF13671.6 EFA76231.1 - 0.003 17.7 0.0 0.018 15.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFA76231.1 - 0.0033 16.8 0.1 0.014 14.7 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EFA76231.1 - 0.0035 16.6 0.0 0.0076 15.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 EFA76231.1 - 0.0083 15.9 0.6 0.27 11.0 0.1 2.8 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFA76231.1 - 0.024 14.4 0.0 0.062 13.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EFA76231.1 - 0.027 14.5 0.1 0.1 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EFA76231.1 - 0.06 12.7 1.0 0.19 11.0 0.0 2.3 3 0 0 3 3 3 0 KaiC Sigma54_activat PF00158.26 EFA76231.1 - 0.063 13.0 0.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EFA76231.1 - 0.068 12.7 0.1 0.17 11.4 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFA76231.1 - 0.09 13.2 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase E1-E2_ATPase PF00122.20 EFA76231.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 E1-E2 ATPase AAA_3 PF07726.11 EFA76231.1 - 0.13 12.2 0.1 0.41 10.5 0.0 2.0 2 1 1 3 3 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EFA76231.1 - 0.14 11.4 0.3 0.48 9.7 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin SVA PF05326.11 EFA76231.1 - 0.15 12.1 0.5 0.26 11.3 0.5 1.3 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) AAA_11 PF13086.6 EFA76231.1 - 0.33 10.7 3.5 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain TIG PF01833.24 EFA76232.1 - 2.6e-25 88.3 63.9 8.4e-09 35.4 5.3 8.0 6 1 2 8 8 8 6 IPT/TIG domain DUF4448 PF14610.6 EFA76232.1 - 0.0014 18.4 1.1 0.0035 17.2 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) ING PF12998.7 EFA76233.1 - 2.3e-21 76.3 4.2 3.3e-21 75.8 4.2 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EFA76233.1 - 8.2e-07 28.8 5.6 1.4e-06 28.1 5.6 1.4 1 0 0 1 1 1 1 PHD-finger Fib_alpha PF08702.10 EFA76233.1 - 0.038 14.2 7.1 0.062 13.5 7.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1474 PF07342.11 EFA76233.1 - 0.044 14.3 1.9 0.074 13.6 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) zf-HC5HC2H PF13771.6 EFA76233.1 - 0.064 13.5 0.1 0.064 13.5 0.1 1.9 3 0 0 3 3 3 0 PHD-like zinc-binding domain Spc7 PF08317.11 EFA76233.1 - 0.34 9.7 9.3 0.53 9.1 9.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein SOGA PF11365.8 EFA76233.1 - 0.55 11.4 7.5 0.17 13.0 3.8 1.9 1 1 1 2 2 2 0 Protein SOGA DUF1451 PF07295.11 EFA76233.1 - 0.99 9.4 5.7 1.5 8.8 5.0 1.6 1 1 0 1 1 1 0 Zinc-ribbon containing domain Prominin PF05478.11 EFA76233.1 - 1 7.3 3.9 1.2 7.0 3.9 1.1 1 0 0 1 1 1 0 Prominin FlxA PF14282.6 EFA76233.1 - 5.8 7.0 8.6 0.37 10.8 3.8 1.6 2 0 0 2 2 2 0 FlxA-like protein Alpha-amylase_C PF02806.18 EFA76234.1 - 3.3e-21 75.5 0.0 9.6e-21 74.1 0.0 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EFA76234.1 - 4e-15 55.9 0.2 1e-14 54.6 0.2 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EFA76234.1 - 1.5e-11 44.4 0.2 1.5e-11 44.4 0.2 2.6 3 1 1 4 4 4 1 Alpha amylase, catalytic domain AMPK1_CBM PF16561.5 EFA76234.1 - 0.04 14.1 0.2 0.15 12.3 0.1 2.0 1 1 1 2 2 2 0 Glycogen recognition site of AMP-activated protein kinase GRAM PF02893.20 EFA76235.1 - 1.2e-07 31.6 0.1 2.8e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 GRAM domain Tho2 PF11262.8 EFA76235.1 - 0.0088 15.3 2.4 0.013 14.7 2.4 1.2 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 HMMR_C PF15908.5 EFA76235.1 - 0.047 14.0 4.7 0.067 13.5 3.2 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal bZIP_1 PF00170.21 EFA76235.1 - 0.047 13.8 4.4 0.27 11.3 0.5 2.6 2 0 0 2 2 2 0 bZIP transcription factor LMBR1 PF04791.16 EFA76235.1 - 0.05 12.5 2.8 0.056 12.3 2.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Csm1_N PF18504.1 EFA76235.1 - 0.24 11.8 7.4 0.43 11.0 4.1 2.5 1 1 1 2 2 2 0 Csm1 N-terminal domain PRKG1_interact PF15898.5 EFA76235.1 - 0.25 12.2 9.0 0.5 11.3 2.7 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain USP8_interact PF08941.10 EFA76235.1 - 0.34 10.7 3.0 0.68 9.7 3.0 1.5 1 0 0 1 1 1 0 USP8 interacting bZIP_2 PF07716.15 EFA76235.1 - 0.41 10.8 4.8 3.1 8.0 0.2 2.7 2 0 0 2 2 2 0 Basic region leucine zipper DUF148 PF02520.17 EFA76235.1 - 0.43 10.7 10.0 1.2 9.2 9.5 2.0 2 1 0 2 2 2 0 Domain of unknown function DUF148 ZapB PF06005.12 EFA76235.1 - 0.86 10.1 8.4 1.5 9.3 0.8 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Cnn_1N PF07989.11 EFA76235.1 - 1 9.5 6.8 5.3 7.3 1.3 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Shugoshin_N PF07558.11 EFA76235.1 - 1.4 8.9 7.5 3.7 7.5 0.6 3.2 2 1 1 3 3 3 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 EFA76235.1 - 3.3 7.6 9.9 8.9 6.2 1.2 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF641 PF04859.12 EFA76236.1 - 0.0046 17.3 4.4 0.0046 17.3 4.4 2.6 1 1 1 2 2 2 1 Plant protein of unknown function (DUF641) HOOK PF05622.12 EFA76236.1 - 0.04 12.1 22.8 0.049 11.8 22.8 1.1 1 0 0 1 1 1 0 HOOK protein Med4 PF10018.9 EFA76236.1 - 0.13 11.9 13.7 0.13 11.9 11.6 2.0 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 KxDL PF10241.9 EFA76236.1 - 0.17 12.2 15.6 0.1 12.9 12.0 2.4 1 1 2 3 3 3 0 Uncharacterized conserved protein FAD-SLDH PF12318.8 EFA76236.1 - 0.21 11.7 2.5 0.39 10.8 2.5 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF4407 PF14362.6 EFA76236.1 - 0.21 10.9 9.5 0.33 10.3 9.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HrpB7 PF09486.10 EFA76236.1 - 0.34 11.3 5.7 0.36 11.2 3.2 2.0 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Tropomyosin PF00261.20 EFA76236.1 - 0.35 10.2 20.8 1.3 8.3 20.8 1.7 1 1 0 1 1 1 0 Tropomyosin ATG16 PF08614.11 EFA76236.1 - 0.37 11.0 26.1 0.54 10.4 20.0 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 EFA76236.1 - 0.77 9.8 11.3 1.1 9.3 6.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) L31 PF09784.9 EFA76236.1 - 1.1 9.8 7.0 2.3 8.7 0.2 2.6 1 1 2 3 3 3 0 Mitochondrial ribosomal protein L31 HMMR_N PF15905.5 EFA76236.1 - 2 7.8 28.1 0.076 12.5 19.2 2.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Golgin_A5 PF09787.9 EFA76236.1 - 2.2 7.7 24.2 2.6 7.4 23.1 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 Occludin_ELL PF07303.13 EFA76236.1 - 4.6 8.0 20.0 1.3 9.7 8.4 3.0 1 1 1 2 2 2 0 Occludin homology domain Atg14 PF10186.9 EFA76236.1 - 5.7 5.9 21.3 16 4.5 21.3 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rootletin PF15035.6 EFA76236.1 - 6.6 6.7 25.7 4.7 7.2 19.6 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FlaC_arch PF05377.11 EFA76236.1 - 9.4 6.7 12.7 2 8.9 2.0 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) HIP1_clath_bdg PF16515.5 EFA76236.1 - 9.7 6.9 24.5 25 5.6 0.9 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Rho_GDI PF02115.17 EFA76239.1 - 0.095 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor Mannosyl_trans2 PF04188.13 EFA76240.1 - 5.1e-33 115.1 19.5 4.7e-30 105.3 13.3 2.2 1 1 1 2 2 2 2 Mannosyltransferase (PIG-V) PMT_2 PF13231.6 EFA76240.1 - 0.022 15.0 6.3 0.022 15.0 6.3 2.4 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Cupin_2 PF07883.11 EFA76241.1 - 3.5e-11 42.7 0.2 3.5e-11 42.7 0.2 2.4 2 1 0 2 2 2 1 Cupin domain Cupin_1 PF00190.22 EFA76241.1 - 8.6e-06 25.4 0.1 1.3e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Cupin JmjC PF02373.22 EFA76241.1 - 0.00012 22.4 4.7 0.00038 20.9 0.0 2.7 2 1 0 2 2 2 1 JmjC domain, hydroxylase FdtA PF05523.11 EFA76241.1 - 0.0073 16.0 0.8 0.029 14.1 0.0 2.0 1 1 1 2 2 2 1 WxcM-like, C-terminal PBP1_TM PF14812.6 EFA76241.1 - 0.16 12.3 3.1 0.29 11.5 3.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2796 PF10986.8 EFA76241.1 - 5.4 7.0 31.0 0.48 10.4 25.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) DUF4357 PF14267.6 EFA76243.1 - 0.36 10.8 1.5 0.67 9.9 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) Tetraspanin PF00335.20 EFA76243.1 - 0.42 10.3 5.7 0.29 10.8 3.7 1.7 1 1 1 2 2 2 0 Tetraspanin family CwfJ_C_1 PF04677.15 EFA76244.1 - 3.8e-29 101.0 0.5 8.4e-29 99.9 0.5 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EFA76244.1 - 4.6e-14 53.1 0.0 1.6e-13 51.3 0.0 1.9 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Glyco_hydro_42C PF08533.10 EFA76244.1 - 0.037 13.7 0.2 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Beta-galactosidase C-terminal domain Afi1 PF07792.12 EFA76244.1 - 1.7 9.1 13.7 2.3 8.7 5.1 2.7 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking UPF0239 PF06783.11 EFA76244.1 - 4.5 7.5 6.4 5.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) zf-UBR PF02207.20 EFA76245.1 - 6.6e-19 67.8 11.6 6.6e-19 67.8 11.6 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EFA76245.1 - 4.7e-09 35.9 0.7 4.4e-08 32.8 0.0 2.6 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS zf-B_box PF00643.24 EFA76245.1 - 0.13 12.4 3.3 0.82 9.9 3.3 2.5 1 0 0 1 1 1 0 B-box zinc finger Complex1_LYR PF05347.15 EFA76247.1 - 2.4e-05 24.3 0.0 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Frag1 PF10277.9 EFA76248.1 - 2.3e-36 125.4 7.1 3.3e-36 124.9 7.1 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Ribosomal_L11_N PF03946.14 EFA76249.1 - 1.6e-18 66.3 0.6 2.9e-18 65.4 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EFA76249.1 - 2.9e-16 59.7 0.2 5.8e-16 58.8 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain SNO PF01174.19 EFA76250.1 - 3.9e-41 141.0 0.0 4.8e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EFA76250.1 - 3.1e-07 30.2 0.3 4.6e-07 29.6 0.1 1.4 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 EFA76250.1 - 0.037 13.7 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S51 SOR_SNZ PF01680.17 EFA76251.1 - 1.6e-111 371.0 6.9 2.5e-111 370.4 6.9 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EFA76251.1 - 8.6e-09 35.1 9.3 1.9e-07 30.6 0.3 2.7 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EFA76251.1 - 0.00025 20.2 0.8 0.04 13.0 0.0 2.6 3 1 0 3 3 3 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 EFA76251.1 - 0.00029 20.9 0.0 0.00085 19.4 0.0 1.8 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain NanE PF04131.14 EFA76251.1 - 0.00059 19.1 2.0 0.049 12.8 0.0 3.0 2 1 1 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 EFA76251.1 - 0.00071 18.8 0.4 0.52 9.4 0.0 2.7 3 0 0 3 3 3 2 Indole-3-glycerol phosphate synthase OMPdecase PF00215.24 EFA76251.1 - 0.0063 16.1 0.1 2.6 7.6 0.0 2.6 1 1 1 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family FMN_dh PF01070.18 EFA76251.1 - 0.0085 15.2 0.4 0.09 11.8 0.0 2.3 3 0 0 3 3 3 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EFA76251.1 - 0.013 14.5 0.4 0.021 13.8 0.4 1.5 1 1 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EFA76251.1 - 0.023 14.1 0.4 0.11 11.9 0.0 2.1 2 1 1 3 3 3 0 Histidine biosynthesis protein NMO PF03060.15 EFA76251.1 - 0.2 11.0 5.1 0.27 10.6 0.1 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase Lsm_C PF14894.6 EFA76251.1 - 1.1 9.0 7.3 3 7.7 0.1 3.5 3 1 1 4 4 4 0 Lsm C-terminal PGI PF00342.19 EFA76252.1 - 9.3e-195 647.8 0.4 9.7e-146 486.2 0.1 2.0 1 1 1 2 2 2 2 Phosphoglucose isomerase DUF4473 PF14747.6 EFA76252.1 - 0.026 15.1 0.1 0.082 13.5 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) CIMR PF00878.18 EFA76254.1 - 3.8e-08 33.5 0.7 6.6e-06 26.2 0.2 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EFA76254.1 - 2.5e-05 24.2 0.4 5.1e-05 23.3 0.4 1.4 1 1 0 1 1 1 1 Autophagy-related protein 27 TGBp3 PF02495.17 EFA76254.1 - 0.056 13.1 0.5 0.31 10.7 0.4 2.1 2 0 0 2 2 2 0 Triple gene block 3 Kunitz_BPTI PF00014.23 EFA76254.1 - 0.42 10.9 4.0 0.19 12.0 0.9 2.1 2 0 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain AT_hook PF02178.19 EFA76255.1 - 4.7e-06 25.9 45.5 0.031 14.1 2.8 4.7 4 0 0 4 4 4 4 AT hook motif Dicty_REP PF05086.12 EFA76255.1 - 1.4 6.8 6.1 1.6 6.6 6.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EFA76255.1 - 6.9 4.7 5.9 8.3 4.4 5.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus tRNA-synt_1 PF00133.22 EFA76256.1 - 1.4e-204 680.8 0.0 1.4e-204 680.8 0.0 2.7 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFA76256.1 - 3.7e-40 137.4 0.2 3.7e-40 137.4 0.2 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFA76256.1 - 1.7e-13 50.1 0.1 7.3e-07 28.3 0.0 3.9 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFA76256.1 - 1.2e-05 24.9 9.3 2.6e-05 23.8 0.0 3.2 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EFA76256.1 - 0.00032 20.2 0.0 0.035 13.5 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain ThiF PF00899.21 EFA76257.1 - 1.3e-101 339.0 0.0 4.7e-72 242.3 0.0 2.3 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFA76257.1 - 1.6e-93 313.3 3.9 1.6e-93 313.3 3.9 2.0 3 0 0 3 3 3 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EFA76257.1 - 5.8e-30 103.8 0.8 5.8e-30 103.8 0.8 2.6 2 0 0 2 2 2 1 Ubiquitin fold domain E1_FCCH PF16190.5 EFA76257.1 - 6.6e-29 99.9 0.5 2.2e-28 98.2 0.3 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EFA76257.1 - 1.2e-18 67.1 1.6 3.2e-18 65.7 1.6 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle NAD_binding_7 PF13241.6 EFA76257.1 - 0.044 14.2 1.7 0.23 11.9 0.2 3.0 3 0 0 3 3 3 0 Putative NAD(P)-binding SUIM_assoc PF16619.5 EFA76257.1 - 0.073 13.1 9.8 0.089 12.9 0.2 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ank_2 PF12796.7 EFA76260.1 - 1.3e-27 96.2 1.2 3.5e-07 30.7 0.1 6.6 6 0 0 6 6 6 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA76260.1 - 6.4e-19 67.8 0.4 3.4e-08 33.6 0.0 6.5 4 1 3 7 7 7 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA76260.1 - 1.4e-18 67.0 10.1 4.6e-05 23.9 0.0 7.7 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76260.1 - 1.3e-15 55.9 3.7 0.018 15.5 0.1 8.3 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 EFA76260.1 - 1.3e-14 53.9 2.8 0.0018 18.6 0.0 7.4 7 0 0 7 7 7 2 Ankyrin repeat F-box-like PF12937.7 EFA76260.1 - 5.5e-11 42.2 0.4 1.6e-10 40.7 0.4 1.8 1 0 0 1 1 1 1 F-box-like zf-TRAF_2 PF15965.5 EFA76260.1 - 1.2e-06 28.9 4.6 5.1e-06 26.9 4.6 2.1 1 0 0 1 1 1 1 TRAF-like zinc-finger F-box PF00646.33 EFA76260.1 - 7.4e-05 22.5 0.3 0.0002 21.1 0.3 1.9 1 0 0 1 1 1 1 F-box domain YojJ PF10372.9 EFA76260.1 - 0.014 15.5 0.1 2.5 8.3 0.0 2.8 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus zf-TRAF PF02176.18 EFA76260.1 - 0.38 11.5 17.6 0.16 12.7 5.6 3.7 1 1 2 3 3 3 0 TRAF-type zinc finger adh_short PF00106.25 EFA76261.1 - 3.7e-50 170.1 0.1 4.7e-50 169.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76261.1 - 6.4e-35 120.8 0.1 7.8e-35 120.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76261.1 - 1.4e-09 38.1 0.2 2.8e-09 37.1 0.2 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA76261.1 - 0.042 13.3 0.0 0.062 12.7 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA76261.1 - 0.054 13.4 0.0 0.086 12.7 0.0 1.5 1 1 0 1 1 1 0 NAD(P)H-binding DUF1372 PF07116.11 EFA76261.1 - 0.072 13.3 0.1 4.2 7.6 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1372) Ank_4 PF13637.6 EFA76262.1 - 5e-06 27.0 1.1 0.00013 22.4 0.3 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA76262.1 - 0.00044 20.8 0.0 0.00052 20.5 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA76262.1 - 0.0015 18.8 0.1 0.64 10.8 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFA76262.1 - 0.0023 18.2 0.2 0.88 10.0 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Cas9_REC PF16592.5 EFA76262.1 - 0.018 13.8 0.2 0.019 13.7 0.2 1.0 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 Ank_2 PF12796.7 EFA76263.1 - 8.3e-21 74.4 5.4 4.8e-05 23.9 0.4 5.1 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76263.1 - 2.7e-17 62.9 11.3 0.0011 19.5 0.1 8.1 6 3 2 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76263.1 - 1.3e-16 60.4 5.9 0.013 15.9 0.0 9.9 4 2 7 11 11 11 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76263.1 - 6.2e-12 44.6 4.3 2.3 9.1 0.0 10.8 10 2 3 13 13 13 2 Ankyrin repeat DUF3447 PF11929.8 EFA76263.1 - 0.015 15.3 25.8 0.32 11.0 0.2 6.9 6 3 2 8 8 8 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA76264.1 - 1.4e-26 92.9 10.9 1.3e-08 35.3 0.4 5.4 1 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76264.1 - 2.7e-26 91.6 16.2 3.8e-05 24.1 0.0 8.0 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76264.1 - 1.1e-20 73.4 15.1 0.0091 16.3 0.1 10.0 4 2 6 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76264.1 - 2.7e-16 58.0 15.2 0.25 12.0 0.0 12.1 12 1 1 13 13 13 3 Ankyrin repeat FNIP PF05725.12 EFA76264.1 - 0.0029 17.7 0.8 0.012 15.8 0.3 2.3 2 0 0 2 2 2 1 FNIP Repeat DUF3447 PF11929.8 EFA76264.1 - 0.012 15.6 28.8 0.025 14.6 0.6 6.4 4 2 1 6 6 6 0 Domain of unknown function (DUF3447) P2_Phage_GpR PF06891.11 EFA76264.1 - 0.1 12.6 1.6 5.5 7.1 0.1 3.2 2 1 1 3 3 3 0 P2 phage tail completion protein R (GpR) TPR_17 PF13431.6 EFA76266.1 - 1.9e-291 920.5 68.9 7.3e-12 44.8 0.0 25.2 24 1 1 25 25 25 25 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76266.1 - 4.4e-30 103.1 68.1 0.29 10.8 0.0 23.3 23 1 1 24 24 24 16 TPR repeat Anth_Ig PF05587.13 EFA76266.1 - 2.2e-18 66.5 70.0 13 6.2 0.1 21.3 22 0 0 22 22 22 7 Anthrax receptor extracellular domain NleF_casp_inhib PF16809.5 EFA76266.1 - 3.8e-09 36.6 22.8 40 4.1 0.0 16.7 9 4 12 21 21 21 0 NleF caspase inhibitor DUF3048_C PF17479.2 EFA76266.1 - 1.6e-08 34.9 14.1 14 6.1 0.1 13.6 10 7 2 17 17 17 2 Protein of unknown function (DUF3048) C-terminal domain Ntox46 PF15538.6 EFA76266.1 - 0.004 17.1 10.3 55 3.7 0.0 9.6 3 3 5 14 14 14 0 Bacterial toxin 46 APG9 PF04109.16 EFA76267.1 - 1.3e-125 420.1 16.2 2.2e-125 419.4 16.2 1.4 1 0 0 1 1 1 1 Autophagy protein Apg9 SET PF00856.28 EFA76267.1 - 1.5e-08 35.2 10.8 1.5e-08 35.2 10.8 2.4 2 1 0 2 2 2 1 SET domain Ependymin PF00811.18 EFA76268.1 - 0.027 14.7 0.6 0.057 13.7 0.2 1.7 2 0 0 2 2 2 0 Ependymin Peptidase_M1 PF01433.20 EFA76269.1 - 2.6e-76 256.0 1.3 4.5e-76 255.2 1.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFA76269.1 - 1.8e-63 215.0 0.0 3.3e-63 214.2 0.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFA76269.1 - 2.6e-52 177.7 2.0 5.6e-52 176.6 0.9 2.0 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Diphthami_syn_2 PF01902.17 EFA76269.1 - 0.078 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Diphthamide synthase CCDC106 PF15794.5 EFA76270.1 - 0.035 13.8 3.9 0.045 13.5 3.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DNA_pol_delta_4 PF04081.13 EFA76270.1 - 0.041 14.2 2.0 0.041 14.2 2.0 1.6 1 1 1 2 2 2 0 DNA polymerase delta, subunit 4 CBS PF00571.28 EFA76272.1 - 3.4e-23 81.8 2.4 5.7e-13 49.1 0.7 2.3 2 0 0 2 2 2 2 CBS domain SnoaL_4 PF13577.6 EFA76272.1 - 0.02 15.0 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain DisA_N PF02457.16 EFA76272.1 - 0.023 14.3 0.1 0.05 13.2 0.1 1.7 1 1 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding Delta_lysin PF05372.11 EFA76272.1 - 0.14 11.5 0.6 0.36 10.2 0.6 1.7 1 0 0 1 1 1 0 Delta lysin family MafB19-deam PF14437.6 EFA76273.1 - 4.4e-26 91.3 0.2 5.8e-26 90.9 0.2 1.2 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 EFA76273.1 - 3.1e-23 81.6 0.7 4.1e-23 81.2 0.7 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.6 EFA76273.1 - 0.0065 16.5 4.0 0.055 13.5 4.0 2.0 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 EFA76273.1 - 0.035 14.2 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EFA76273.1 - 0.066 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 APOBEC3 BTB_2 PF02214.22 EFA76274.1 - 4e-16 59.1 0.6 1.1e-15 57.7 0.6 1.8 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EFA76274.1 - 0.002 18.3 0.1 0.055 13.8 0.0 3.0 3 0 0 3 3 3 1 Kelch motif DUF4564 PF15169.6 EFA76274.1 - 0.062 13.0 1.1 12 5.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4564) Ank_2 PF12796.7 EFA76275.1 - 0.00064 20.3 2.4 2.4 8.8 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Orf78 PF06024.12 EFA76275.1 - 3.1 8.2 11.2 12 6.3 11.2 2.0 1 0 0 1 1 1 0 Orf78 (ac78) FNIP PF05725.12 EFA76276.1 - 1.3e-51 172.5 66.7 2e-11 43.8 0.0 16.9 14 5 5 19 19 19 14 FNIP Repeat IMCp PF12314.8 EFA76276.1 - 0.72 10.2 4.9 17 5.8 1.0 2.5 2 0 0 2 2 2 0 Inner membrane complex protein FNIP PF05725.12 EFA76277.1 - 6e-28 96.8 26.8 2.3e-11 43.7 0.0 9.2 5 2 5 10 10 10 7 FNIP Repeat F-box_5 PF18511.1 EFA76277.1 - 1.2e-05 24.7 0.7 3.1e-05 23.4 0.7 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA76277.1 - 0.0013 18.6 0.6 0.018 14.9 0.4 2.7 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 EFA76277.1 - 0.0088 15.9 0.2 0.45 10.5 0.7 2.9 2 0 0 2 2 2 1 F-box domain DUF4973 PF16343.5 EFA76277.1 - 0.12 12.5 2.0 0.53 10.3 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4973) SMC_N PF02463.19 EFA76279.1 - 1.7e-49 168.3 59.7 1.7e-49 168.3 59.7 3.2 3 1 0 3 3 2 1 RecF/RecN/SMC N terminal domain Clathrin PF00637.20 EFA76279.1 - 1.7e-23 83.1 1.1 1.7e-23 83.1 1.1 4.0 4 0 0 4 4 4 1 Region in Clathrin and VPS SMC_hinge PF06470.13 EFA76279.1 - 1.7e-21 76.7 0.2 6.5e-21 74.8 0.2 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EFA76279.1 - 2.5e-11 43.9 10.9 2.5e-11 43.9 10.9 5.9 4 2 2 6 6 5 2 AAA ATPase domain AAA_21 PF13304.6 EFA76279.1 - 1.2e-07 31.8 18.7 3.6e-05 23.7 2.4 4.2 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Vps39_2 PF10367.9 EFA76279.1 - 9.5e-07 29.2 2.1 9.5e-07 29.2 2.1 3.3 2 0 0 2 2 1 1 Vacuolar sorting protein 39 domain 2 THOC7 PF05615.13 EFA76279.1 - 0.00024 21.4 18.6 0.00024 21.4 18.6 6.9 3 2 2 5 5 3 1 Tho complex subunit 7 WD40 PF00400.32 EFA76279.1 - 0.00055 20.7 0.0 0.0022 18.8 0.0 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat FlaC_arch PF05377.11 EFA76279.1 - 0.00082 19.7 2.3 0.00082 19.7 2.3 11.0 10 2 2 12 12 10 1 Flagella accessory protein C (FlaC) AAA_29 PF13555.6 EFA76279.1 - 0.0011 18.6 0.1 0.0034 17.1 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain TolA_bind_tri PF16331.5 EFA76279.1 - 0.0075 16.3 0.1 0.0075 16.3 0.1 7.9 6 2 2 8 8 5 1 TolA binding protein trimerisation zf-ANAPC11 PF12861.7 EFA76279.1 - 0.071 13.2 0.8 0.18 11.9 0.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3H2C3 PF17122.5 EFA76279.1 - 0.15 12.1 2.7 0.39 10.8 2.7 1.7 1 0 0 1 1 1 0 Zinc-finger zf-rbx1 PF12678.7 EFA76279.1 - 0.22 11.8 6.0 0.04 14.2 1.8 2.0 2 0 0 2 2 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFA76279.1 - 0.53 10.1 4.6 1.6 8.5 4.6 1.9 1 0 0 1 1 1 0 RING-like zinc finger C1_1 PF00130.22 EFA76279.1 - 0.63 10.0 2.4 2.2 8.2 2.4 1.9 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CBFD_NFYB_HMF PF00808.23 EFA76280.1 - 9.3e-16 57.9 0.8 1.4e-15 57.3 0.8 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mucin PF01456.17 EFA76280.1 - 0.00053 20.0 8.4 0.0011 19.0 8.4 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein YL1 PF05764.13 EFA76280.1 - 0.002 18.3 5.6 0.0035 17.5 5.6 1.4 1 0 0 1 1 1 1 YL1 nuclear protein Nop14 PF04147.12 EFA76280.1 - 0.0022 16.3 7.7 0.0029 15.9 7.7 1.2 1 0 0 1 1 1 1 Nop14-like family BSP_II PF05432.11 EFA76280.1 - 0.0025 17.6 13.8 0.0043 16.8 13.8 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) CobT PF06213.12 EFA76280.1 - 0.0089 15.5 7.4 0.013 14.9 7.4 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Cwf_Cwc_15 PF04889.12 EFA76280.1 - 0.012 15.4 11.7 0.022 14.5 11.7 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.12 EFA76280.1 - 0.017 13.7 17.7 0.029 13.0 17.7 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PI3K_1B_p101 PF10486.9 EFA76280.1 - 0.027 12.3 2.7 0.049 11.4 2.7 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SDA1 PF05285.12 EFA76280.1 - 0.028 13.9 9.5 0.04 13.3 9.5 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EFA76280.1 - 0.044 13.1 14.1 0.081 12.3 14.1 1.4 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EFA76280.1 - 0.092 11.0 9.0 0.12 10.6 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein FoP_duplication PF13865.6 EFA76280.1 - 0.3 11.6 15.4 0.9 10.1 15.4 1.8 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 AJAP1_PANP_C PF15298.6 EFA76280.1 - 0.7 10.1 13.6 0.22 11.7 4.3 3.0 3 0 0 3 3 3 0 AJAP1/PANP C-terminus FAM176 PF14851.6 EFA76280.1 - 1.3 8.7 6.3 3.3 7.4 6.3 1.7 1 0 0 1 1 1 0 FAM176 family DUF3439 PF11921.8 EFA76280.1 - 1.6 8.7 12.3 3.8 7.5 12.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) B277 PF17623.2 EFA76280.1 - 2.2 7.3 4.7 3.5 6.6 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function DNA_pol_phi PF04931.13 EFA76280.1 - 4.2 5.4 24.6 6 4.8 24.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 EFA76280.1 - 4.4 7.3 11.5 3.1 7.8 9.4 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal PBP1_TM PF14812.6 EFA76280.1 - 4.7 7.6 16.4 16 6.0 16.4 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SNF2_N PF00176.23 EFA76283.1 - 1.3e-75 254.3 0.1 2.6e-75 253.3 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA76283.1 - 6.1e-18 65.2 0.0 2.6e-16 59.9 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain PHD PF00628.29 EFA76283.1 - 8.4e-11 41.6 10.3 8.4e-11 41.6 10.3 2.7 2 0 0 2 2 2 1 PHD-finger zf-C3HC4 PF00097.25 EFA76283.1 - 4.1e-06 26.5 9.3 4.1e-06 26.5 9.3 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA76283.1 - 2.7e-05 24.4 8.3 2.7e-05 24.4 8.3 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFA76283.1 - 0.00018 21.3 7.1 0.00018 21.3 7.1 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA76283.1 - 0.00035 20.5 5.6 0.0011 18.9 5.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFA76283.1 - 0.00046 20.0 8.5 0.00046 20.0 8.5 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFA76283.1 - 0.0072 16.2 1.5 0.019 14.8 1.5 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-MIZ PF02891.20 EFA76283.1 - 0.028 14.2 8.0 0.011 15.4 5.2 1.9 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger PHD_2 PF13831.6 EFA76283.1 - 0.94 9.1 11.0 0.017 14.7 3.7 1.9 2 0 0 2 2 2 0 PHD-finger zf-Nse PF11789.8 EFA76283.1 - 0.95 9.3 4.8 2.4 8.1 4.8 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EFA76283.1 - 3.5 7.6 6.2 13 5.7 6.2 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Pkinase PF00069.25 EFA76284.1 - 2.1e-40 138.7 0.0 8.1e-14 51.6 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76284.1 - 3.7e-25 88.7 0.0 1.4e-09 37.6 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase SUIM_assoc PF16619.5 EFA76284.1 - 0.017 15.2 0.3 0.017 15.2 0.3 4.5 4 1 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Kdo PF06293.14 EFA76284.1 - 0.024 14.0 0.0 0.056 12.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFA76284.1 - 0.06 13.0 0.1 2.5 7.7 0.0 2.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FNIP PF05725.12 EFA76285.1 - 9e-65 214.6 68.0 8.8e-14 51.4 0.4 16.7 14 3 5 19 19 19 13 FNIP Repeat F-box_5 PF18511.1 EFA76285.1 - 0.019 14.5 0.1 0.039 13.5 0.1 1.4 1 0 0 1 1 1 0 F-box HATPase_c PF02518.26 EFA76286.1 - 8.7e-26 90.6 0.5 3.1e-25 88.8 0.5 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA76286.1 - 2.3e-25 88.9 0.1 6.7e-25 87.4 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain RNase_PH PF01138.21 EFA76286.1 - 2.3e-21 76.7 0.0 6.7e-21 75.2 0.0 1.9 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 HisKA PF00512.25 EFA76286.1 - 2.7e-17 62.6 2.0 5.2e-17 61.6 0.2 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain RNase_PH_C PF03725.15 EFA76286.1 - 1.7e-13 50.4 2.5 1.1e-12 47.8 0.8 2.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 GAF PF01590.26 EFA76286.1 - 4.9e-07 30.4 0.0 1.2e-06 29.2 0.0 1.7 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 EFA76286.1 - 3.1e-05 24.3 0.0 6.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EFA76286.1 - 0.0052 17.1 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EFA76286.1 - 0.0082 16.0 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AraC_binding PF02311.19 EFA76286.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.9 1 0 0 1 1 1 0 AraC-like ligand binding domain AAA_16 PF13191.6 EFA76287.1 - 3e-34 118.9 0.0 1.8e-33 116.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Pre-PUA PF17832.1 EFA76287.1 - 3.5e-19 69.3 0.9 7.9e-19 68.1 0.2 2.1 2 0 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 EFA76287.1 - 1.3e-11 44.3 0.0 2.5e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 PUA domain Pkinase PF00069.25 EFA76287.1 - 1.7e-05 24.4 0.0 4.2e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain AAA_22 PF13401.6 EFA76287.1 - 0.005 17.1 0.0 0.027 14.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain Pkinase_Tyr PF07714.17 EFA76287.1 - 0.074 12.3 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein tyrosine kinase Zeta_toxin PF06414.12 EFA76287.1 - 0.16 11.2 0.0 0.31 10.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 EFA76287.1 - 0.74 10.4 3.3 4.3 7.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain Peptidase_C1 PF00112.23 EFA76288.1 - 1.2e-47 162.8 10.5 1.2e-47 162.8 10.5 1.9 2 0 0 2 2 2 1 Papain family cysteine protease CAP PF00188.26 EFA76288.1 - 7.1e-13 49.5 8.9 7.1e-13 49.5 8.9 2.8 3 0 0 3 3 3 1 Cysteine-rich secretory protein family Peptidase_C1_2 PF03051.15 EFA76288.1 - 0.0013 17.6 2.7 0.045 12.5 0.2 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Meiosis_expr PF15163.6 EFA76288.1 - 0.065 13.9 0.1 0.26 12.0 0.1 2.0 1 0 0 1 1 1 0 Meiosis-expressed Glycoprotein PF03409.15 EFA76288.1 - 0.5 9.2 4.3 0.35 9.7 1.9 1.9 2 0 0 2 2 2 0 Transmembrane glycoprotein Inhibitor_I29 PF08246.12 EFA76289.1 - 1.2e-12 48.1 0.2 5.3e-12 46.0 0.2 2.1 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) FemAB PF02388.16 EFA76289.1 - 0.14 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 FemAB family VSP PF03302.13 EFA76289.1 - 5.6 5.7 7.2 7.8 5.2 7.2 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein HSP70 PF00012.20 EFA76290.1 - 2.8e-85 286.8 13.6 2.3e-49 168.1 9.6 3.9 2 2 1 4 4 4 2 Hsp70 protein RED_N PF07808.13 EFA76290.1 - 1.1e-17 64.5 13.7 1.1e-17 64.5 13.7 4.6 3 1 2 5 5 5 2 RED-like protein N-terminal region FGGY_C PF02782.16 EFA76290.1 - 0.0052 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain MreB_Mbl PF06723.13 EFA76290.1 - 0.022 13.6 0.1 1.1 8.0 0.0 2.3 2 0 0 2 2 2 0 MreB/Mbl protein Y_phosphatase2 PF03162.13 EFA76291.1 - 6.5e-40 136.4 0.5 1.6e-39 135.1 0.0 2.0 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFA76291.1 - 0.0097 15.9 0.0 0.029 14.3 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family CRAL_TRIO PF00650.20 EFA76292.1 - 2.4e-36 124.9 0.1 3.9e-36 124.2 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFA76292.1 - 2.5e-09 37.2 3.6 7.2e-09 35.7 3.6 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFA76292.1 - 9.3e-08 32.3 0.0 1.6e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SL4P PF17618.2 EFA76292.1 - 0.0052 16.8 0.9 0.011 15.8 0.9 1.4 1 0 0 1 1 1 1 Uncharacterized Strongylid L4 protein C2 PF00168.30 EFA76293.1 - 4.3e-17 62.3 0.0 6.9e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 C2 domain dUTPase PF00692.19 EFA76294.1 - 4.5e-12 45.8 0.0 8.6e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 dUTPase LAGLIDADG_3 PF14528.6 EFA76294.1 - 0.00011 22.4 0.0 0.00069 19.9 0.0 2.2 2 0 0 2 2 2 1 LAGLIDADG-like domain LAGLIDADG_WhiA PF14527.6 EFA76294.1 - 0.076 13.1 0.0 13 6.0 0.0 2.4 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain DnaJ PF00226.31 EFA76295.1 - 1.2e-23 83.0 2.8 2e-23 82.2 2.8 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EFA76295.1 - 9.3e-19 68.0 0.0 1.8e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EFA76295.1 - 3.2e-08 33.8 13.0 6e-08 32.9 13.0 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFA76295.1 - 0.16 11.9 9.7 0.065 13.2 1.0 2.7 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein CxC3 PF18804.1 EFA76295.1 - 0.32 10.9 2.1 0.61 10.0 2.1 1.5 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases A2L_zn_ribbon PF08792.10 EFA76295.1 - 2.8 7.8 15.3 0.54 10.0 0.6 4.0 3 1 1 4 4 4 0 A2L zinc ribbon domain H_lectin PF09458.10 EFA76296.1 - 1.4e-17 63.6 2.2 2.3e-17 62.9 0.5 2.3 2 0 0 2 2 2 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA76296.1 - 1.1e-16 61.1 0.7 2e-16 60.3 0.4 1.5 2 0 0 2 2 2 1 F5/8 type C domain Pkinase PF00069.25 EFA76297.1 - 1.7e-63 214.4 0.0 3.8e-63 213.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76297.1 - 8.7e-42 143.2 0.0 1.4e-41 142.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFA76297.1 - 5e-05 22.4 3.7 8.9e-05 21.6 3.7 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFA76297.1 - 0.00013 22.0 0.0 0.0004 20.4 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA76297.1 - 0.0086 14.9 0.0 0.0086 14.9 0.0 2.9 3 1 1 4 4 4 1 Fungal protein kinase RIO1 PF01163.22 EFA76297.1 - 0.0088 15.7 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EFA76297.1 - 0.012 15.2 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase F-112 PF09645.10 EFA76297.1 - 0.016 15.3 0.8 0.046 13.8 0.1 2.1 2 0 0 2 2 2 0 F-112 protein Kdo PF06293.14 EFA76297.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFA76297.1 - 0.022 14.1 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Macoilin PF09726.9 EFA76299.1 - 0.01 14.5 10.0 0.01 14.5 10.0 1.0 1 0 0 1 1 1 0 Macoilin family Mem_trans PF03547.18 EFA76299.1 - 0.044 12.2 9.6 0.055 11.8 9.6 1.1 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 EFA76299.1 - 0.11 11.2 10.2 0.15 10.8 10.2 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EFA76299.1 - 0.38 9.7 8.1 0.58 9.1 8.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 YfhO PF09586.10 EFA76299.1 - 0.54 8.4 17.0 0.68 8.1 17.0 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO ALMT PF11744.8 EFA76299.1 - 0.65 8.8 9.3 0.83 8.4 9.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NST1 PF13945.6 EFA76299.1 - 0.65 10.1 23.0 0.99 9.5 23.0 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator RP-C_C PF11800.8 EFA76299.1 - 0.86 9.7 5.5 1.4 8.9 5.5 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 EFA76299.1 - 0.86 8.8 4.1 0.99 8.6 4.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RIFIN PF02009.16 EFA76299.1 - 0.96 9.3 4.6 1.2 8.9 4.6 1.2 1 0 0 1 1 1 0 Rifin Gti1_Pac2 PF09729.9 EFA76299.1 - 1.9 8.6 11.4 2.6 8.1 11.4 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family CLN3 PF02487.17 EFA76299.1 - 2.3 7.2 3.7 3.2 6.7 3.7 1.2 1 0 0 1 1 1 0 CLN3 protein SWI-SNF_Ssr4 PF08549.10 EFA76299.1 - 2.4 6.7 9.9 3.1 6.3 9.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Trigger_C PF05698.14 EFA76300.1 - 0.091 12.8 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus PHF12_MRG_bd PF16737.5 EFA76300.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain Ribosomal_L33 PF00471.20 EFA76300.1 - 0.32 11.5 0.0 0.32 11.5 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L33 Ephrin_rec_like PF07699.13 EFA76301.1 - 1.6e-10 40.6 67.9 0.00014 21.5 10.1 7.4 1 1 6 7 7 7 6 Putative ephrin-receptor like GYF PF02213.16 EFA76301.1 - 1.4e-08 34.2 0.6 3.3e-08 33.0 0.6 1.7 1 0 0 1 1 1 1 GYF domain NCD3G PF07562.14 EFA76301.1 - 2.1e-05 24.4 46.2 0.051 13.6 2.1 5.8 5 0 0 5 5 5 3 Nine Cysteines Domain of family 3 GPCR SIT PF15330.6 EFA76301.1 - 0.0085 16.5 0.1 0.0085 16.5 0.1 3.3 4 0 0 4 4 4 1 SHP2-interacting transmembrane adaptor protein, SIT LapA_dom PF06305.11 EFA76301.1 - 0.25 11.2 0.7 0.56 10.1 0.7 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 EFA76301.1 - 0.4 11.6 3.0 5.3 8.0 0.0 3.1 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain DUF2681 PF10883.8 EFA76301.1 - 0.56 10.6 8.4 0.49 10.8 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) FtsX PF02687.21 EFA76301.1 - 0.9 10.1 2.7 0.46 11.0 0.1 1.7 2 0 0 2 2 2 0 FtsX-like permease family DUF624 PF04854.14 EFA76302.1 - 0.0089 16.1 1.5 0.014 15.5 1.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF624 Spatacsin_C PF14649.6 EFA76302.1 - 0.024 13.8 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 Spatacsin C-terminus zf-UBR PF02207.20 EFA76303.1 - 2.5e-17 62.8 13.4 2.5e-17 62.8 13.4 3.1 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) zf-RING_5 PF14634.6 EFA76303.1 - 3.4e-05 23.7 1.9 3.4e-05 23.7 1.9 3.4 4 0 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA76303.1 - 0.00023 21.4 2.6 0.00023 21.4 2.6 4.0 4 0 0 4 4 4 1 Ring finger domain zf-rbx1 PF12678.7 EFA76303.1 - 0.0012 19.0 0.9 0.0012 19.0 0.9 2.9 2 1 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA76303.1 - 0.0024 17.7 1.6 0.0024 17.7 1.6 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) LRR_6 PF13516.6 EFA76305.1 - 5.1 7.4 12.6 8 6.8 0.0 5.9 5 0 0 5 5 5 0 Leucine Rich repeat Macoilin PF09726.9 EFA76305.1 - 8.5 4.8 14.5 20 3.5 14.5 1.6 1 0 0 1 1 1 0 Macoilin family HEAT PF02985.22 EFA76306.1 - 2.4e-25 86.4 6.5 0.00011 22.2 0.0 11.5 12 0 0 12 12 12 5 HEAT repeat HEAT_2 PF13646.6 EFA76306.1 - 7.9e-15 55.0 1.6 0.031 14.6 0.0 7.7 4 2 4 8 8 8 5 HEAT repeats HEAT_EZ PF13513.6 EFA76306.1 - 1.4e-14 54.2 0.1 7.9e-08 32.6 0.0 5.7 3 2 1 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EFA76306.1 - 1.1e-11 45.2 8.2 0.024 15.2 1.1 7.9 4 3 3 8 8 7 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFA76306.1 - 4.3e-10 39.5 6.4 6.2e-05 22.7 0.4 6.2 4 1 3 7 7 7 3 CLASP N terminal IBN_N PF03810.19 EFA76306.1 - 4.9e-10 39.2 0.3 2.2e-09 37.1 0.3 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Arm PF00514.23 EFA76306.1 - 2.1e-09 37.1 0.1 0.0094 16.0 0.0 4.8 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EFA76306.1 - 5.2e-09 36.3 5.5 0.00022 21.3 0.0 4.4 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EFA76306.1 - 5.3e-05 22.5 6.6 0.18 10.9 0.0 5.0 3 2 1 5 5 5 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EFA76306.1 - 0.00044 19.9 3.1 0.13 11.8 0.1 4.7 4 2 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II UME PF08064.13 EFA76306.1 - 0.00078 19.3 2.9 3.9 7.4 0.0 5.0 3 2 2 5 5 5 1 UME (NUC010) domain RIX1 PF08167.12 EFA76306.1 - 0.0067 16.2 3.2 10 5.8 0.1 5.2 3 2 2 6 6 6 0 rRNA processing/ribosome biogenesis DUF3385 PF11865.8 EFA76306.1 - 0.0086 16.0 10.6 0.11 12.4 0.9 5.1 4 4 2 6 6 6 1 Domain of unknown function (DUF3385) MOR2-PAG1_C PF14225.6 EFA76306.1 - 0.04 13.8 2.5 34 4.2 0.4 4.2 3 1 2 5 5 5 0 Cell morphogenesis C-terminal TAF6_C PF07571.13 EFA76306.1 - 0.075 13.4 0.7 19 5.6 0.0 4.8 4 2 0 4 4 3 0 TAF6 C-terminal HEAT repeat domain DUF577 PF04510.12 EFA76306.1 - 0.24 11.3 5.3 1.8 8.5 0.0 3.6 3 1 1 4 4 4 0 Family of unknown function (DUF577) Tti2 PF10521.9 EFA76306.1 - 0.51 9.8 7.6 0.66 9.5 0.9 4.1 4 2 1 6 6 6 0 Tti2 family IFT81_CH PF18383.1 EFA76306.1 - 1.9 8.7 7.4 0.39 11.0 0.5 3.1 3 0 0 3 3 3 0 Intraflagellar transport 81 calponin homology domain ApeC PF16977.5 EFA76307.1 - 0.035 14.1 0.1 0.044 13.7 0.1 1.2 1 1 0 1 1 1 0 C-terminal domain of apextrin CppA_C PF14507.6 EFA76307.1 - 0.035 14.8 0.1 0.051 14.3 0.1 1.3 1 0 0 1 1 1 0 CppA C-terminal DUF2500 PF10694.9 EFA76307.1 - 0.097 13.2 0.6 0.2 12.2 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2500) Uma2 PF05685.12 EFA76308.1 - 6e-06 25.9 0.1 9.9e-06 25.2 0.1 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease UAA PF08449.11 EFA76310.1 - 3.6e-24 85.5 13.4 1e-23 84.0 13.4 1.7 1 1 0 1 1 1 1 UAA transporter family PI-PLC-X PF00388.19 EFA76311.1 - 4.9e-59 198.1 0.0 8.4e-59 197.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFA76311.1 - 5.1e-30 104.2 0.0 2.1e-29 102.2 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EFA76311.1 - 3.6e-18 65.7 0.0 1.8e-17 63.5 0.0 2.2 2 0 0 2 2 2 1 C2 domain EF-hand_like PF09279.11 EFA76311.1 - 1.8e-07 31.6 0.2 5.6e-07 29.9 0.2 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like GDPD PF03009.17 EFA76311.1 - 0.0018 18.0 0.3 0.037 13.7 0.0 2.4 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family SR-25 PF10500.9 EFA76311.1 - 0.004 16.8 6.0 0.0066 16.1 6.0 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PH_12 PF16457.5 EFA76311.1 - 0.0089 16.6 0.1 0.0089 16.6 0.1 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain Tub_N PF16322.5 EFA76311.1 - 0.092 13.1 1.5 0.17 12.2 1.5 1.4 1 0 0 1 1 1 0 Tubby N-terminal EF-hand_7 PF13499.6 EFA76311.1 - 0.17 12.4 3.8 0.26 11.8 1.9 2.3 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EFA76311.1 - 0.18 11.4 1.5 0.5 10.0 0.6 2.3 2 0 0 2 2 2 0 EF hand RNA_pol_Rpb4 PF03874.16 EFA76313.1 - 5.8e-16 58.9 1.0 5.8e-16 58.9 1.0 3.4 2 1 0 2 2 1 1 RNA polymerase Rpb4 Kelch_6 PF13964.6 EFA76313.1 - 8.9e-12 44.9 2.3 0.0096 16.2 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFA76313.1 - 6.9e-05 22.8 0.3 0.15 12.1 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA76313.1 - 0.00013 21.4 4.6 0.011 15.3 0.0 3.9 4 1 0 4 4 4 1 Kelch motif zf-B_box PF00643.24 EFA76313.1 - 0.00044 20.3 4.7 0.0013 18.9 4.7 1.8 1 0 0 1 1 1 1 B-box zinc finger Kelch_5 PF13854.6 EFA76313.1 - 0.0023 17.9 6.9 0.039 13.9 0.0 4.0 4 0 0 4 4 4 1 Kelch motif HDC PF02329.16 EFA76313.1 - 0.024 13.6 0.1 0.057 12.4 0.0 1.6 2 0 0 2 2 2 0 Histidine carboxylase PI chain zf-UBR PF02207.20 EFA76313.1 - 0.085 13.0 2.6 0.29 11.3 2.6 1.9 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) YojJ PF10372.9 EFA76313.1 - 0.24 11.5 2.3 1.3 9.1 2.3 2.3 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus IBR PF01485.21 EFA76313.1 - 4.9 7.5 6.9 1.2e+02 3.0 5.0 2.9 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 EFA76313.1 - 8.7 6.3 6.4 84 3.1 0.0 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cg6151-P PF10233.9 EFA76314.1 - 0.5 10.7 14.2 0.89 9.9 14.1 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P Syndecan PF01034.20 EFA76315.1 - 0.0079 16.1 1.3 0.018 14.9 1.3 1.5 1 0 0 1 1 1 1 Syndecan domain Adeno_E3_CR2 PF02439.15 EFA76315.1 - 0.02 14.6 1.4 0.051 13.3 1.4 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 MRF_C2 PF13888.6 EFA76315.1 - 0.057 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Myelin gene regulatory factor C-terminal domain 2 DUF4690 PF15756.5 EFA76315.1 - 0.075 13.6 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 Small Novel Rich in Cartilage PTP_tm PF18861.1 EFA76315.1 - 0.078 13.0 0.1 0.078 13.0 0.1 2.4 3 0 0 3 3 3 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Adeno_E3_CR2 PF02439.15 EFA76316.1 - 0.0021 17.8 1.2 0.0021 17.8 1.2 2.7 2 0 0 2 2 2 1 Adenovirus E3 region protein CR2 Chlam_PMP PF02415.17 EFA76316.1 - 0.0026 18.1 2.0 0.0026 18.1 2.0 14.7 17 1 0 17 17 17 3 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SKG6 PF08693.10 EFA76316.1 - 0.38 10.2 6.3 0.064 12.7 0.6 2.5 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Syndecan PF01034.20 EFA76316.1 - 9 6.3 6.4 31 4.6 0.3 2.5 2 0 0 2 2 2 0 Syndecan domain Beta_helix PF13229.6 EFA76317.1 - 3.3e-09 36.8 59.9 3.5e-06 27.0 28.5 3.6 1 1 2 3 3 3 2 Right handed beta helix region Adeno_E3_CR2 PF02439.15 EFA76317.1 - 0.038 13.8 0.5 0.097 12.4 0.5 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Syndecan PF01034.20 EFA76317.1 - 0.05 13.5 0.7 0.13 12.2 0.7 1.7 1 0 0 1 1 1 0 Syndecan domain Podoplanin PF05808.11 EFA76318.1 - 5.6e-05 23.3 0.2 5.6e-05 23.3 0.2 2.2 2 0 0 2 2 2 1 Podoplanin DUF4690 PF15756.5 EFA76318.1 - 0.015 15.9 0.2 0.06 13.9 0.0 2.1 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Sigma_reg_N PF13800.6 EFA76318.1 - 0.028 14.7 5.2 0.14 12.5 0.1 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Adeno_E3_CR2 PF02439.15 EFA76318.1 - 0.087 12.6 5.2 0.22 11.3 5.2 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF2613 PF11021.8 EFA76318.1 - 0.1 12.7 1.3 0.46 10.6 1.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) TNFR_16_TM PF18422.1 EFA76318.1 - 0.14 12.1 0.2 0.14 12.1 0.2 2.8 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain MtrG PF04210.13 EFA76318.1 - 0.17 11.7 2.1 2.9 7.8 0.2 3.0 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G EphA2_TM PF14575.6 EFA76318.1 - 0.18 12.7 0.2 0.37 11.7 0.2 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Utp11 PF03998.13 EFA76319.1 - 3.9e-52 177.6 16.3 4.3e-52 177.5 16.3 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EFA76319.1 - 0.13 11.6 1.9 0.16 11.3 0.9 1.6 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 BCS1_N PF08740.11 EFA76320.1 - 3e-35 121.9 0.0 4.6e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EFA76320.1 - 1.5e-19 70.8 0.0 3.6e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EFA76320.1 - 8.9e-05 21.8 0.0 0.00014 21.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFA76320.1 - 0.0015 18.3 0.0 0.0046 16.7 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFA76320.1 - 0.0017 18.7 0.0 0.0087 16.5 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFA76320.1 - 0.0033 17.1 0.0 0.013 15.3 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFA76320.1 - 0.0035 17.4 0.0 0.013 15.6 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFA76320.1 - 0.0086 16.6 0.0 0.026 15.0 0.0 1.8 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EFA76320.1 - 0.024 14.6 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 EFA76320.1 - 0.046 14.1 0.0 0.16 12.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EFA76320.1 - 0.094 11.9 0.0 0.21 10.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 EFA76320.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SART-1 PF03343.13 EFA76321.1 - 5.7e-78 263.0 78.6 2.5e-65 221.3 68.9 2.5 1 1 1 2 2 2 2 SART-1 family Secretin_N_2 PF07655.13 EFA76322.1 - 0.003 18.0 12.3 0.007 16.9 12.3 1.6 1 0 0 1 1 1 1 Secretin N-terminal domain Pex2_Pex12 PF04757.14 EFA76322.1 - 0.016 14.8 4.4 0.024 14.2 4.4 1.4 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region PDGF_N PF04692.13 EFA76322.1 - 0.61 10.9 2.0 1.7 9.5 2.0 1.7 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region PARP PF00644.20 EFA76327.1 - 5.1e-50 169.8 0.0 9.4e-50 168.9 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFA76327.1 - 9.3e-38 129.4 2.9 1.7e-37 128.5 2.9 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PADR1 PF08063.12 EFA76327.1 - 2e-17 62.7 1.2 4.9e-17 61.5 1.2 1.7 1 0 0 1 1 1 1 PADR1 (NUC008) domain WGR PF05406.15 EFA76327.1 - 1.4e-14 53.9 0.2 4.8e-14 52.2 0.1 2.0 2 0 0 2 2 2 1 WGR domain zf-PARP PF00645.18 EFA76327.1 - 3.7e-10 40.5 0.0 9e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF4549 PF15082.6 EFA76327.1 - 0.12 12.1 1.6 0.16 11.8 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4549) COQ7 PF03232.13 EFA76328.1 - 5.7e-69 231.3 0.0 1.3e-68 230.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 PUF PF00806.19 EFA76328.1 - 1.4e-38 128.4 19.2 9.7e-08 31.3 0.2 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Rubrerythrin PF02915.17 EFA76328.1 - 3.4e-06 27.5 0.0 1.1e-05 25.8 0.0 1.9 1 0 0 1 1 1 1 Rubrerythrin CPL PF08144.11 EFA76328.1 - 0.00011 22.6 6.3 0.0029 17.9 1.1 4.2 2 1 1 4 4 4 1 CPL (NUC119) domain Ferritin_2 PF13668.6 EFA76328.1 - 0.04 14.1 1.2 6.4 7.0 0.2 2.7 1 1 0 2 2 2 0 Ferritin-like domain DUF2164 PF09932.9 EFA76328.1 - 0.056 13.5 0.1 14 5.8 0.0 3.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) DrrA_P4M PF14860.6 EFA76328.1 - 7.6 6.4 7.8 0.82 9.5 0.1 3.3 4 0 0 4 4 4 0 DrrA phosphatidylinositol 4-phosphate binding domain EnY2 PF10163.9 EFA76328.1 - 8.6 6.8 6.1 5.9 7.3 0.0 3.6 5 0 0 5 5 5 0 Transcription factor e(y)2 Flagellar_put PF12611.8 EFA76329.1 - 1.1 9.1 4.3 22 5.0 0.2 3.0 2 0 0 2 2 2 0 Putative flagellar Pkinase PF00069.25 EFA76330.1 - 1.6e-61 208.0 0.2 2.9e-61 207.2 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76330.1 - 8e-37 126.9 0.0 1.1e-36 126.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA76330.1 - 3.6e-08 33.1 0.0 6.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFA76330.1 - 0.0004 20.0 0.2 0.0012 18.5 0.2 1.7 1 0 0 1 1 1 1 RIO1 family RXT2_N PF08595.11 EFA76330.1 - 0.031 14.3 5.5 0.074 13.1 5.5 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal Pkinase_fungal PF17667.1 EFA76330.1 - 0.035 12.9 0.0 0.035 12.9 0.0 2.0 3 0 0 3 3 3 0 Fungal protein kinase Kdo PF06293.14 EFA76330.1 - 0.046 13.1 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA76330.1 - 0.048 13.6 0.0 0.84 9.5 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family FAM176 PF14851.6 EFA76330.1 - 0.048 13.3 1.7 0.096 12.4 1.7 1.4 1 0 0 1 1 1 0 FAM176 family FTA2 PF13095.6 EFA76330.1 - 0.097 12.3 1.1 1 9.0 0.0 2.8 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 NOA36 PF06524.12 EFA76330.1 - 0.18 11.1 6.1 0.34 10.2 6.1 1.5 1 0 0 1 1 1 0 NOA36 protein DUF3439 PF11921.8 EFA76330.1 - 0.27 11.2 13.1 0.77 9.7 13.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CENP-B_dimeris PF09026.10 EFA76330.1 - 0.35 11.3 5.3 0.96 9.9 5.3 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EFA76330.1 - 2 8.8 5.0 4 7.9 5.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3245 PF11595.8 EFA76330.1 - 2.2 8.8 9.2 1.8 9.1 7.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) Mucin PF01456.17 EFA76330.1 - 3.7 7.5 20.5 11 6.1 20.5 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2076 PF09849.9 EFA76330.1 - 5.9 6.9 8.4 10 6.1 8.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) ParBc PF02195.18 EFA76331.1 - 7.4e-11 42.2 0.0 9.5e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain Sugar_tr PF00083.24 EFA76332.1 - 4.7e-105 352.1 24.0 5.7e-105 351.8 24.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFA76332.1 - 5.7e-43 147.2 28.8 2.1e-36 125.6 22.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFA76332.1 - 1.1e-11 43.9 33.1 1.3e-07 30.6 3.2 4.1 2 2 2 4 4 4 4 MFS/sugar transport protein MFS_4 PF06779.14 EFA76332.1 - 4.1e-05 23.0 1.2 4.1e-05 23.0 1.2 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EFA76332.1 - 0.0025 16.8 21.2 0.0032 16.4 7.0 2.3 1 1 1 2 2 2 2 MFS_1 like family NDUF_B12 PF08122.12 EFA76332.1 - 0.034 14.2 2.3 0.76 9.9 0.2 3.0 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family adh_short PF00106.25 EFA76333.1 - 2.6e-43 147.8 0.0 1.3e-42 145.5 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase Glycos_transf_2 PF00535.26 EFA76333.1 - 8.5e-37 126.6 0.0 1.9e-36 125.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 adh_short_C2 PF13561.6 EFA76333.1 - 3.9e-31 108.4 0.0 6.9e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_tranf_2_3 PF13641.6 EFA76333.1 - 4.8e-13 49.5 0.0 8.2e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 KR PF08659.10 EFA76333.1 - 1.9e-08 34.4 0.0 4.3e-08 33.3 0.0 1.6 2 0 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 EFA76333.1 - 9e-07 28.6 0.3 1.7e-06 27.7 0.3 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA76333.1 - 3.4e-06 26.7 0.1 6.4e-06 25.8 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_21 PF13506.6 EFA76333.1 - 1.3e-05 24.8 0.0 2.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EFA76333.1 - 0.026 14.0 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF4549 PF15082.6 EFA76333.1 - 0.14 11.9 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4549) NAD_binding_10 PF13460.6 EFA76333.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding CAP PF00188.26 EFA76334.1 - 3.5e-11 44.0 0.0 4.6e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family LIM PF00412.22 EFA76335.1 - 2.2e-13 50.2 7.7 2.6e-13 50.0 7.7 1.1 1 0 0 1 1 1 1 LIM domain YdjO PF14169.6 EFA76335.1 - 0.36 10.6 0.0 0.36 10.6 0.0 2.8 2 1 1 3 3 3 0 Cold-inducible protein YdjO YacG PF03884.14 EFA76335.1 - 0.45 10.3 7.7 3.8 7.3 0.2 2.1 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-B_box PF00643.24 EFA76335.1 - 3 8.0 12.8 11 6.2 8.3 2.6 1 1 1 2 2 2 0 B-box zinc finger zf_UBZ PF18439.1 EFA76335.1 - 4.3 7.0 7.2 15 5.3 0.9 3.2 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger Sugar_tr PF00083.24 EFA76336.1 - 5.9e-100 335.3 22.5 1.1e-55 189.3 7.2 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFA76336.1 - 3e-43 148.1 36.9 2.5e-28 99.0 8.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFA76336.1 - 8.6e-08 31.1 12.6 0.00012 20.6 6.3 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EFA76336.1 - 1.7e-06 27.6 3.6 1.7e-06 27.6 3.6 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB F-box PF00646.33 EFA76337.1 - 0.0001 22.1 1.0 0.00018 21.3 1.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA76337.1 - 0.022 14.6 0.4 0.048 13.6 0.4 1.5 1 0 0 1 1 1 0 F-box-like Phage_Coat_B PF05356.11 EFA76337.1 - 0.17 11.8 0.2 0.3 11.0 0.2 1.3 1 0 0 1 1 1 0 Phage Coat protein B Pyr_redox_2 PF07992.14 EFA76339.1 - 2e-42 145.4 0.0 3e-42 144.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EFA76339.1 - 8.7e-11 40.6 6.2 2e-05 23.8 0.3 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EFA76339.1 - 3.8e-09 36.9 2.9 2.9e-08 34.0 3.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair Pyr_redox PF00070.27 EFA76339.1 - 1.4e-07 32.0 0.0 1.9e-06 28.4 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_6 PF13405.6 EFA76339.1 - 1.4e-06 27.7 8.7 0.0084 16.0 0.8 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EFA76339.1 - 0.00018 20.8 6.5 0.11 12.1 1.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFA76339.1 - 0.63 9.9 4.1 1.1 9.2 0.2 2.5 2 0 0 2 2 2 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA76339.1 - 1.4 9.3 4.4 17 5.8 2.6 3.2 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region IBR PF01485.21 EFA76340.1 - 5.6e-06 26.5 9.4 5.6e-06 26.5 9.4 2.7 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain RIH_assoc PF08454.11 EFA76340.1 - 4.7e-05 23.2 0.7 0.0037 17.1 0.0 2.8 2 0 0 2 2 2 1 RyR and IP3R Homology associated Prefoldin_2 PF01920.20 EFA76340.1 - 0.0094 15.9 0.2 0.025 14.5 0.2 1.7 1 0 0 1 1 1 1 Prefoldin subunit OpcA_G6PD_assem PF10128.9 EFA76340.1 - 0.15 11.6 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit Pkinase_Tyr PF07714.17 EFA76341.1 - 8e-71 238.3 0.0 1.2e-70 237.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA76341.1 - 3.2e-64 216.9 0.0 8.4e-64 215.5 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Sec1 PF00995.23 EFA76343.1 - 7.6e-125 418.3 12.1 8.9e-125 418.1 12.1 1.1 1 0 0 1 1 1 1 Sec1 family V-ATPase_H_C PF11698.8 EFA76343.1 - 0.0034 17.5 0.6 0.016 15.3 0.5 2.2 1 1 0 1 1 1 1 V-ATPase subunit H Flavodoxin_3 PF12641.7 EFA76343.1 - 0.016 14.9 0.1 0.046 13.4 0.1 1.9 1 0 0 1 1 1 0 Flavodoxin domain DGF-1_C PF11040.8 EFA76344.1 - 0.17 11.9 0.2 3.3 7.8 0.3 2.3 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SdrD_B PF17210.3 EFA76346.1 - 1.6e-26 92.7 5.2 1.4e-14 54.3 0.3 2.6 3 0 0 3 3 3 2 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA76346.1 - 7.8e-16 58.1 0.6 1.2e-06 28.7 0.1 2.5 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA76346.1 - 2.1e-08 34.4 0.1 0.0023 18.2 0.0 2.8 2 0 0 2 2 2 2 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA76346.1 - 0.0039 17.1 1.1 1.8 8.6 0.1 2.8 2 1 0 2 2 2 2 CarboxypepD_reg-like domain DUF2012 PF09430.10 EFA76346.1 - 0.0096 16.0 0.0 5.4 7.1 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF2012) FlgD_ig PF13860.6 EFA76346.1 - 0.12 12.3 0.1 0.47 10.4 0.1 2.1 1 1 0 1 1 1 0 FlgD Ig-like domain MetallophosN PF16371.5 EFA76346.1 - 0.3 11.4 2.2 15 5.9 0.0 3.2 3 0 0 3 3 3 0 N terminal of Calcineurin-like phosphoesterase Invasin_D3 PF09134.10 EFA76346.1 - 0.48 10.8 2.1 3.6 8.0 0.1 3.0 2 1 0 2 2 2 0 Invasin, domain 3 Ldh_1_C PF02866.18 EFA76347.1 - 6e-34 117.4 0.0 2.2e-33 115.5 0.0 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFA76347.1 - 3.5e-33 114.6 0.3 5.8e-33 114.0 0.3 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NLPC_P60 PF00877.19 EFA76348.1 - 1.7e-11 44.1 0.1 2.5e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 NlpC/P60 family KH_6 PF15985.5 EFA76349.1 - 1.3e-13 51.1 0.1 2.2e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EFA76349.1 - 4.3e-06 26.6 0.0 8.9e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain ECR1_N PF14382.6 EFA76349.1 - 0.097 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region RRM_1 PF00076.22 EFA76350.1 - 9.5e-28 95.8 0.4 7.9e-13 48.0 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA76350.1 - 2e-12 46.8 0.0 3.3e-05 23.5 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA76350.1 - 0.00028 20.7 0.0 0.37 10.7 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF4523 PF15023.6 EFA76350.1 - 0.025 14.4 0.1 0.084 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Peptidase_S66C PF17676.1 EFA76350.1 - 0.16 12.5 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain CPSF100_C PF13299.6 EFA76350.1 - 0.48 10.6 4.0 0.82 9.8 1.3 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PHM7_cyt PF14703.6 EFA76350.1 - 2.5 8.3 11.6 12 6.1 0.1 3.4 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF3464 PF11947.8 EFA76350.1 - 4 7.2 6.7 0.15 11.8 1.0 1.6 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF4047 PF13256.6 EFA76351.1 - 0.66 10.2 7.7 2.3 8.4 1.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) PT PF04886.12 EFA76352.1 - 0.41 10.2 2.3 1.2 8.7 0.8 2.4 2 1 0 2 2 2 0 PT repeat Pkinase_Tyr PF07714.17 EFA76353.1 - 3e-52 177.5 0.0 4.3e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA76353.1 - 1.5e-49 168.7 0.0 2.5e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFA76353.1 - 0.012 15.0 0.0 0.037 13.4 0.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PRAP PF15314.6 EFA76353.1 - 0.056 13.9 0.6 0.23 11.9 0.6 2.1 1 0 0 1 1 1 0 Proline-rich acidic protein 1, pregnancy-specific uterine DNA_pol_E_B PF04042.16 EFA76354.1 - 8.9e-48 162.4 2.5 1.7e-47 161.5 2.5 1.5 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 EFA76354.1 - 8.8e-10 38.7 0.3 8.8e-10 38.7 0.3 2.1 2 0 0 2 2 2 1 DNA polymerases epsilon N terminal Lipoprotein_15 PF03640.15 EFA76355.1 - 3.8e-52 173.6 16.2 3.4e-13 48.9 1.6 6.6 7 0 0 7 7 7 6 Secreted repeat of unknown function Rhomboid_N PF12122.8 EFA76356.1 - 0.021 15.0 2.1 1.7 8.9 0.6 2.9 2 0 0 2 2 2 0 Cytoplasmic N-terminal domain of rhomboid serine protease zf-BED PF02892.15 EFA76356.1 - 0.05 13.6 3.4 0.12 12.4 3.4 1.7 1 0 0 1 1 1 0 BED zinc finger DUF3439 PF11921.8 EFA76356.1 - 0.16 12.0 0.6 0.46 10.5 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Phage_Mu_F PF04233.14 EFA76356.1 - 0.4 11.4 5.0 0.49 11.2 2.7 2.1 2 0 0 2 2 2 0 Phage Mu protein F like protein ALMT PF11744.8 EFA76357.1 - 3.5e-40 138.3 18.3 8.1e-40 137.0 18.3 1.6 1 0 0 1 1 1 1 Aluminium activated malate transporter FUSC_2 PF13515.6 EFA76357.1 - 5.8e-21 74.9 20.2 9.5e-21 74.2 20.2 1.4 1 0 0 1 1 1 1 Fusaric acid resistance protein-like FUSC PF04632.12 EFA76357.1 - 1.4e-19 70.2 14.0 3.3e-19 68.9 12.7 2.2 2 1 0 2 2 2 1 Fusaric acid resistance protein family Rick_17kDa_Anti PF05433.15 EFA76357.1 - 0.16 11.8 0.2 0.29 11.0 0.2 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain MNHE PF01899.16 EFA76357.1 - 2.7 7.8 8.6 1.2 8.9 2.1 2.6 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit Peptidase_U4 PF03419.13 EFA76357.1 - 9.5 5.4 13.1 18 4.5 13.1 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Bac_rhamnosid6H PF17389.2 EFA76358.1 - 0.032 13.5 0.0 0.034 13.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PLDc PF00614.22 EFA76359.1 - 4e-21 74.3 0.5 6.4e-09 35.6 0.0 3.6 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFA76359.1 - 4.4e-18 65.4 0.2 3.9e-12 46.2 0.2 3.1 3 0 0 3 3 3 2 PLD-like domain Alba PF01918.21 EFA76360.1 - 3.8e-06 26.6 0.4 5.8e-06 26.0 0.4 1.3 1 0 0 1 1 1 1 Alba SLAM PF06214.11 EFA76360.1 - 0.032 14.3 0.2 0.046 13.7 0.2 1.4 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein UbiA PF01040.18 EFA76361.1 - 8.1e-52 176.0 15.7 1.1e-51 175.6 15.7 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF2109 PF09882.9 EFA76361.1 - 0.051 13.6 0.8 0.17 11.9 0.8 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2109) BRO1 PF03097.18 EFA76363.1 - 1.2e-28 100.1 1.0 1.8e-28 99.5 1.0 1.2 1 0 0 1 1 1 1 BRO1-like domain RNA_pol_Rpc4 PF05132.14 EFA76363.1 - 0.05 14.0 11.8 0.17 12.3 2.4 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 SPG48 PF14764.6 EFA76363.1 - 0.058 13.9 0.3 0.11 12.9 0.3 1.4 1 0 0 1 1 1 0 AP-5 complex subunit, vesicle trafficking DDHD PF02862.17 EFA76363.1 - 0.12 12.5 6.3 0.76 9.9 0.9 2.4 2 0 0 2 2 2 0 DDHD domain YL1 PF05764.13 EFA76363.1 - 0.37 10.9 19.3 0.033 14.3 11.2 2.1 2 0 0 2 2 2 0 YL1 nuclear protein SDA1 PF05285.12 EFA76363.1 - 0.98 8.8 27.7 0.075 12.4 17.2 2.1 2 0 0 2 2 2 0 SDA1 Zip PF02535.22 EFA76363.1 - 1.3 8.2 7.7 0.075 12.2 0.3 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Na_trans_assoc PF06512.13 EFA76363.1 - 1.5 9.0 17.4 4.9 7.4 0.6 2.4 2 0 0 2 2 2 0 Sodium ion transport-associated SURF2 PF05477.11 EFA76363.1 - 1.7 8.3 24.5 2.9 7.5 1.5 3.1 3 0 0 3 3 3 0 Surfeit locus protein 2 (SURF2) SLC12 PF03522.15 EFA76363.1 - 2.2 7.2 11.7 1.4 7.9 5.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 CDC45 PF02724.14 EFA76363.1 - 2.3 6.4 22.9 0.53 8.5 12.8 2.2 2 0 0 2 2 2 0 CDC45-like protein BUD22 PF09073.10 EFA76363.1 - 3.7 6.8 30.3 4.4 6.6 3.3 2.1 2 0 0 2 2 2 0 BUD22 Pex14_N PF04695.13 EFA76363.1 - 5.3 7.7 10.5 19 5.9 0.6 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 EFA76363.1 - 8.4 5.0 15.0 0.96 8.1 5.6 2.2 2 0 0 2 2 2 0 Presenilin Pyrid_oxidase_2 PF13883.6 EFA76364.1 - 1.6e-11 44.5 0.0 2.9e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF2470 PF10615.9 EFA76364.1 - 2.1e-10 41.1 0.0 4.4e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pro_isomerase PF00160.21 EFA76366.1 - 1.9e-47 161.4 0.1 2.2e-47 161.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ResIII PF04851.15 EFA76367.1 - 4.2e-19 69.2 0.0 4.2e-19 69.2 0.0 5.1 5 1 0 5 5 5 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFA76367.1 - 9.6e-19 67.8 0.1 3.7e-18 65.9 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA76367.1 - 5e-16 59.0 0.0 1.9e-14 53.8 0.0 2.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase FANCM-MHF_bd PF16783.5 EFA76367.1 - 0.00019 21.5 1.1 0.00019 21.5 1.1 2.6 2 0 0 2 2 2 1 FANCM to MHF binding domain HUN PF08729.10 EFA76367.1 - 0.048 13.7 7.4 0.28 11.2 7.4 2.4 1 0 0 1 1 1 0 HPC2 and ubinuclein domain DUF2189 PF09955.9 EFA76368.1 - 0.054 13.7 1.0 0.054 13.7 1.0 1.6 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) Phage_holin_3_6 PF07332.11 EFA76368.1 - 0.12 12.4 5.8 0.18 11.9 5.8 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3040 PF11239.8 EFA76368.1 - 0.35 11.2 4.3 0.63 10.4 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Sporozoite_P67 PF05642.11 EFA76368.1 - 1.9 6.5 9.0 0.67 8.0 5.3 1.8 2 0 0 2 2 2 0 Sporozoite P67 surface antigen CBS PF00571.28 EFA76369.1 - 3.8e-12 46.5 1.4 1.9e-05 25.0 0.4 3.9 4 0 0 4 4 4 3 CBS domain Phage-MuB_C PF09077.11 EFA76369.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Mu B transposition protein, C terminal Erf4 PF10256.9 EFA76370.1 - 0.00056 20.0 1.6 0.003 17.7 0.1 2.5 1 1 1 2 2 2 1 Golgin subfamily A member 7/ERF4 family ABC_membrane_3 PF13748.6 EFA76370.1 - 0.0016 17.7 0.1 0.0023 17.2 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Wzy_C PF04932.15 EFA76370.1 - 0.0072 16.0 0.1 0.0097 15.6 0.1 1.2 1 0 0 1 1 1 1 O-Antigen ligase Ig_mannosidase PF17753.1 EFA76370.1 - 0.032 14.0 0.1 0.1 12.4 0.0 1.9 2 1 0 2 2 2 0 Ig-fold domain Shisa PF13908.6 EFA76370.1 - 0.4 10.9 1.3 0.97 9.6 1.3 1.6 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1673 PF07895.11 EFA76370.1 - 3.3 7.4 8.2 0.098 12.4 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) 7tm_2 PF00002.24 EFA76371.1 - 4.6e-09 35.9 13.1 4.6e-09 35.9 13.1 1.6 2 1 0 2 2 2 1 7 transmembrane receptor (Secretin family) Ocular_alb PF02101.15 EFA76371.1 - 3.3e-06 26.3 9.6 5.1e-06 25.7 9.6 1.2 1 0 0 1 1 1 1 Ocular albinism type 1 protein Frizzled PF01534.17 EFA76371.1 - 5.7e-06 25.6 12.2 8.9e-06 25.0 11.1 1.9 2 0 0 2 2 2 1 Frizzled/Smoothened family membrane region 7tm_1 PF00001.21 EFA76371.1 - 0.0016 17.9 17.5 0.0016 17.9 17.5 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Wzy_C_2 PF11846.8 EFA76371.1 - 1.8 8.4 4.7 3.4 7.5 0.8 2.6 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal Cofilin_ADF PF00241.20 EFA76372.1 - 5.7e-15 55.2 5.2 3.2e-11 43.1 0.1 3.2 3 0 0 3 3 3 2 Cofilin/tropomyosin-type actin-binding protein ETC_C1_NDUFA5 PF04716.14 EFA76373.1 - 1e-23 82.9 0.2 1.6e-23 82.3 0.2 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region HECT PF00632.25 EFA76374.1 - 2.6e-67 227.5 1.1 2.6e-67 227.5 1.1 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.19 EFA76374.1 - 2.8e-20 73.1 15.3 9.3e-15 55.3 2.7 4.0 4 0 0 4 4 4 2 Filamin/ABP280 repeat SusF_SusE PF16411.5 EFA76374.1 - 0.051 14.1 10.1 0.07 13.6 4.5 3.4 3 1 0 3 3 3 0 Outer membrane protein SusF_SusE NAD_kinase PF01513.21 EFA76375.1 - 5e-65 219.6 0.1 9.9e-65 218.6 0.1 1.4 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EFA76375.1 - 0.048 13.3 0.1 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain TPALS PF18178.1 EFA76375.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family GET2 PF08690.10 EFA76375.1 - 4.2 7.0 11.0 11 5.6 11.0 1.6 1 0 0 1 1 1 0 GET complex subunit GET2 CASP_C PF08172.12 EFA76377.1 - 1.2e-62 211.5 0.3 1.2e-62 211.5 0.3 4.3 1 1 2 4 4 4 1 CASP C terminal Acetyltransf_10 PF13673.7 EFA76377.1 - 2.7e-05 24.1 0.1 0.0001 22.3 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Macoilin PF09726.9 EFA76377.1 - 4.1e-05 22.3 17.0 4.1e-05 22.3 17.0 2.6 3 0 0 3 3 3 1 Macoilin family CENP-F_leu_zip PF10473.9 EFA76377.1 - 0.0035 17.4 46.9 0.098 12.7 18.4 3.7 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Acetyltransf_1 PF00583.25 EFA76377.1 - 0.0039 17.4 0.1 0.009 16.2 0.1 1.7 2 0 0 2 2 1 1 Acetyltransferase (GNAT) family Golgin_A5 PF09787.9 EFA76377.1 - 0.0098 15.4 40.3 0.055 12.9 0.0 4.0 2 1 1 4 4 4 2 Golgin subfamily A member 5 DNA_pack_N PF02500.15 EFA76377.1 - 0.0099 15.7 1.6 0.032 14.1 1.6 1.9 1 0 0 1 1 1 1 Probable DNA packing protein, N-terminus CENP-H PF05837.12 EFA76377.1 - 0.011 16.2 10.3 0.011 16.2 10.3 3.9 2 1 2 4 4 4 0 Centromere protein H (CENP-H) FlaC_arch PF05377.11 EFA76377.1 - 0.012 16.0 35.1 0.085 13.3 1.8 6.2 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) VGPC1_C PF16799.5 EFA76377.1 - 0.019 15.0 10.7 3.6 7.6 0.0 4.5 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Acetyltransf_7 PF13508.7 EFA76377.1 - 0.044 14.2 0.6 0.18 12.2 0.2 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain eIF_4EBP PF05456.11 EFA76377.1 - 0.045 13.7 1.6 0.19 11.6 1.6 2.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Acetyltransf_9 PF13527.7 EFA76377.1 - 0.065 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NDUF_B8 PF05821.11 EFA76377.1 - 0.12 12.2 0.1 0.22 11.4 0.1 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) HrpB7 PF09486.10 EFA76377.1 - 0.44 10.9 9.8 0.13 12.6 2.4 3.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) ERM PF00769.19 EFA76377.1 - 1.6 8.5 34.4 0.76 9.6 28.1 2.5 2 1 0 2 2 2 0 Ezrin/radixin/moesin family Chorion_3 PF05387.11 EFA76377.1 - 5.2 6.6 6.9 2.6 7.6 0.4 2.4 2 0 0 2 2 2 0 Chorion family 3 KASH_CCD PF14662.6 EFA76377.1 - 5.3 6.8 46.2 2.6 7.8 1.9 3.3 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH RhlB PF12300.8 EFA76377.1 - 7.5 6.7 10.0 16 5.6 10.0 1.4 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB RCC1 PF00415.18 EFA76379.1 - 4e-57 190.6 17.4 5.7e-07 30.1 0.0 14.0 14 1 0 14 14 14 12 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA76379.1 - 5.4e-45 150.3 32.5 1.5e-08 34.2 1.1 11.9 12 0 0 12 12 12 11 Regulator of chromosome condensation (RCC1) repeat hSac2 PF12456.8 EFA76379.1 - 6.4e-15 54.9 0.2 1.3e-14 53.9 0.2 1.5 1 0 0 1 1 1 1 Inositol phosphatase Chorion_1 PF01723.16 EFA76379.1 - 0.052 13.5 1.6 0.25 11.3 1.6 2.1 1 0 0 1 1 1 0 Chorion protein COesterase PF00135.28 EFA76380.1 - 2.3e-120 402.9 0.0 3e-120 402.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA76380.1 - 6.9e-05 22.8 0.6 0.00055 19.9 0.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA76380.1 - 0.19 11.2 0.1 0.33 10.4 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family eIF2A PF08662.11 EFA76381.1 - 1.4e-55 188.2 4.8 2.3e-52 177.7 0.6 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EFA76381.1 - 8.4e-10 38.3 1.0 1.8e-09 37.3 0.1 2.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MciZ PF13072.6 EFA76381.1 - 0.02 14.7 0.1 0.066 13.0 0.1 1.9 1 0 0 1 1 1 0 Mother cell inhibitor of FtsZ IKI3 PF04762.12 EFA76381.1 - 0.022 12.8 0.1 0.066 11.2 0.0 1.7 1 1 1 2 2 2 0 IKI3 family Methyltr_RsmF_N PF17125.5 EFA76381.1 - 0.12 12.8 0.6 36 5.0 0.1 3.7 2 2 1 3 3 3 0 N-terminal domain of 16S rRNA methyltransferase RsmF WD40 PF00400.32 EFA76381.1 - 0.12 13.2 3.9 3.4 8.7 0.1 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat Ras PF00071.22 EFA76382.1 - 9.2e-40 135.9 0.7 1.2e-23 83.5 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFA76382.1 - 2e-14 53.8 0.0 3.8e-14 52.9 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFA76382.1 - 0.0073 16.2 0.0 0.3 11.0 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase Syntaxin-18_N PF10496.9 EFA76382.1 - 0.036 14.3 1.3 0.096 12.9 1.0 1.8 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus LcrG PF07216.12 EFA76382.1 - 0.047 13.6 0.1 0.076 12.9 0.1 1.4 1 0 0 1 1 1 0 LcrG protein AAA_25 PF13481.6 EFA76382.1 - 0.083 12.5 0.0 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFA76382.1 - 0.36 11.3 1.6 12 6.3 0.2 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cortex-I_coil PF09304.10 EFA76383.1 - 1.4e-48 163.5 27.4 1.4e-48 163.5 27.4 2.4 2 1 0 2 2 2 1 Cortexillin I, coiled coil CH PF00307.31 EFA76383.1 - 1.5e-42 144.2 0.6 7e-23 80.9 0.3 2.6 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA76383.1 - 6.4e-05 22.7 0.2 0.8 9.6 0.0 3.3 3 1 0 3 3 3 2 CAMSAP CH domain Host_attach PF10116.9 EFA76383.1 - 0.0098 16.5 3.5 0.2 12.2 0.1 2.6 2 0 0 2 2 2 1 Protein required for attachment to host cells DUF3450 PF11932.8 EFA76383.1 - 1.1 8.5 18.9 0.042 13.2 7.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EFA76383.1 - 2.8 8.0 10.0 0.24 11.4 2.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) RA PF00788.23 EFA76384.1 - 0.0019 18.8 0.1 0.0024 18.5 0.1 1.2 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Carm_PH PF17888.1 EFA76384.1 - 0.075 13.4 0.7 0.12 12.7 0.5 1.4 1 1 0 1 1 1 0 Carmil pleckstrin homology domain CH PF00307.31 EFA76385.1 - 1.8e-16 60.3 0.7 4.9e-16 58.9 0.7 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 EFA76385.1 - 0.057 13.5 2.7 0.058 13.5 0.2 2.3 3 0 0 3 3 3 0 CH-like domain in sperm protein TEP1_N PF05386.11 EFA76388.1 - 0.043 13.4 0.2 0.073 12.7 0.2 1.4 1 0 0 1 1 1 0 TEP1 N-terminal domain Phage_Gp23 PF10669.9 EFA76388.1 - 0.84 10.0 9.2 0.25 11.7 2.6 2.4 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) Dicty_spore_N PF04562.12 EFA76389.1 - 4.9e-37 127.1 39.1 3.7e-24 85.6 22.4 7.3 5 2 2 8 8 8 2 Dictyostelium spore coat protein, N terminus LMBR1 PF04791.16 EFA76389.1 - 7.5e-27 94.4 23.9 4.5e-15 55.6 2.4 2.5 1 1 1 2 2 2 2 LMBR1-like membrane protein FOLN PF09289.10 EFA76389.1 - 0.015 15.4 5.7 0.015 15.4 5.7 11.3 12 0 0 12 12 12 0 Follistatin/Osteonectin-like EGF domain PsbT PF01405.17 EFA76389.1 - 3.5 7.5 7.7 10 6.0 7.7 1.8 1 0 0 1 1 1 0 Photosystem II reaction centre T protein Pho88 PF10032.9 EFA76390.1 - 1.5e-37 128.6 0.0 2.2e-37 128.1 0.0 1.2 1 1 0 1 1 1 1 Phosphate transport (Pho88) PDR_CDR PF06422.12 EFA76390.1 - 0.12 12.3 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 CDR ABC transporter SPC25 PF06703.11 EFA76390.1 - 0.38 10.5 2.6 1.3 8.8 1.5 2.1 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) LRR_8 PF13855.6 EFA76391.1 - 0.015 15.1 5.4 2.6 7.9 0.4 4.0 4 0 0 4 4 4 0 Leucine rich repeat EGF_Tenascin PF18720.1 EFA76391.1 - 0.12 12.5 10.3 0.36 10.9 10.3 1.9 1 0 0 1 1 1 0 Tenascin EGF domain C2 PF00168.30 EFA76392.1 - 5e-22 78.1 0.0 1.2e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain LRR_8 PF13855.6 EFA76392.1 - 3.6e-21 74.7 10.9 8.3e-09 35.1 0.1 3.6 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFA76392.1 - 2.3e-20 72.3 16.7 4.5e-06 26.9 0.7 5.7 3 2 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA76392.1 - 0.00033 20.8 18.7 1.8 9.5 0.1 8.7 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_9 PF14580.6 EFA76392.1 - 0.0004 19.9 11.0 0.013 15.1 1.1 3.5 1 1 3 4 4 4 3 Leucine-rich repeat Atrophin-1 PF03154.15 EFA76392.1 - 0.42 8.9 8.4 0.57 8.4 8.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family Dicty_REP PF05086.12 EFA76392.1 - 0.72 7.8 4.6 1.1 7.2 4.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LRR_6 PF13516.6 EFA76392.1 - 1.7 8.9 16.7 25 5.3 0.1 6.9 7 0 0 7 7 7 0 Leucine Rich repeat Suf PF05843.14 EFA76392.1 - 3.3 7.6 6.4 4.9 7.0 6.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Isochorismatase PF00857.20 EFA76394.1 - 2.2e-33 115.9 0.0 2.5e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family PAP2 PF01569.21 EFA76395.1 - 4.3e-16 58.9 4.9 4.3e-16 58.9 4.9 2.1 2 0 0 2 2 2 1 PAP2 superfamily Kelch_1 PF01344.25 EFA76396.1 - 5.3e-38 128.4 0.1 2.6e-09 36.5 0.0 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFA76396.1 - 4.7e-35 118.7 6.0 4.1e-08 33.2 0.0 6.3 3 2 3 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFA76396.1 - 1.9e-31 107.7 0.1 1.5e-05 25.2 0.0 8.1 8 0 0 8 8 8 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA76396.1 - 5.3e-29 99.1 4.4 4e-07 29.8 0.0 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EFA76396.1 - 6.2e-29 99.8 4.8 4.8e-09 36.1 0.0 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA76396.1 - 3.5e-28 97.1 4.4 6.5e-06 26.0 0.0 6.4 6 0 0 6 6 6 6 Kelch motif F-box-like PF12937.7 EFA76396.1 - 2.2e-10 40.3 0.3 4.7e-10 39.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA76396.1 - 2.1e-05 24.3 0.2 4.4e-05 23.2 0.2 1.6 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EFA76396.1 - 0.0061 17.1 0.3 0.012 16.1 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box_4 PF15966.5 EFA76396.1 - 0.11 12.4 0.1 0.33 10.9 0.1 1.8 1 0 0 1 1 1 0 F-box TauE PF01925.19 EFA76398.1 - 0.026 14.1 0.1 0.026 14.1 0.1 1.8 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE V-SNARE_C PF12352.8 EFA76399.1 - 7.8e-08 32.5 1.8 1.7e-07 31.4 1.8 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Laminin_II PF06009.12 EFA76399.1 - 0.0044 17.0 2.7 0.6 10.1 0.4 2.3 2 0 0 2 2 2 2 Laminin Domain II DASH_Dad4 PF08650.10 EFA76399.1 - 0.0082 16.1 2.5 0.01 15.8 0.4 2.2 2 0 0 2 2 2 1 DASH complex subunit Dad4 DUF948 PF06103.11 EFA76399.1 - 0.023 14.9 1.8 0.6 10.4 0.1 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) PID_2 PF14719.6 EFA76399.1 - 0.044 13.6 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF745 PF05335.13 EFA76399.1 - 0.088 12.5 0.7 1.8 8.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) CREPT PF16566.5 EFA76399.1 - 0.13 12.4 2.9 0.1 12.8 1.2 1.6 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour APG6_N PF17675.1 EFA76399.1 - 0.74 10.3 7.5 0.48 11.0 4.2 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF29 PF01724.16 EFA76399.1 - 1.3 9.3 7.0 2.7 8.2 0.5 2.9 1 1 1 3 3 3 0 Domain of unknown function DUF29 Myb_DNA-binding PF00249.31 EFA76400.1 - 4.1e-09 36.5 0.0 0.0031 17.7 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain HTH_AsnC-type PF13404.6 EFA76400.1 - 0.034 14.0 0.0 0.083 12.7 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Sulfatase_C PF14707.6 EFA76400.1 - 0.069 13.9 0.9 0.25 12.1 0.9 1.9 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase FAM60A PF15396.6 EFA76400.1 - 3.8 7.4 9.2 0.47 10.4 2.8 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Beach PF02138.18 EFA76401.1 - 5.6e-118 393.3 0.1 1.1e-117 392.4 0.1 1.5 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 EFA76401.1 - 2.6e-16 59.7 21.3 0.0013 19.6 0.7 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat PH_BEACH PF14844.6 EFA76401.1 - 6.3e-14 51.9 3.5 6.1e-12 45.5 0.8 4.0 3 1 0 3 3 3 1 PH domain associated with Beige/BEACH WD40_like PF17005.5 EFA76401.1 - 1.5e-12 47.5 9.6 1e-09 38.2 1.3 2.8 2 1 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 EFA76401.1 - 1.5e-11 44.4 1.0 0.079 13.3 0.1 4.9 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain GRAM PF02893.20 EFA76401.1 - 1.5e-08 34.5 1.2 0.0001 22.1 0.2 2.7 2 0 0 2 2 2 2 GRAM domain BBS2_Mid PF14783.6 EFA76401.1 - 0.0032 17.5 1.9 0.25 11.4 0.0 4.1 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region bPH_3 PF14470.6 EFA76401.1 - 0.036 14.4 0.3 0.19 12.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial PH domain Jak1_Phl PF17887.1 EFA76401.1 - 0.48 10.4 4.2 6.4 6.7 3.0 2.3 1 1 1 2 2 2 0 Jak1 pleckstrin homology-like domain Methyltransf_2 PF00891.18 EFA76402.1 - 1e-36 126.2 0.0 1.3e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA76402.1 - 0.00019 21.3 0.0 0.00038 20.4 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.6 EFA76402.1 - 0.00069 19.5 0.0 0.0019 18.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain TrmB PF01978.19 EFA76402.1 - 0.051 13.5 0.0 0.57 10.1 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 EFA76402.1 - 0.08 13.1 0.0 0.22 11.7 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain MetW PF07021.12 EFA76402.1 - 0.088 12.4 0.1 0.57 9.7 0.0 2.1 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW IPPT PF01715.17 EFA76402.1 - 0.097 12.5 0.0 0.72 9.6 0.0 2.0 2 0 0 2 2 2 0 IPP transferase Myb_DNA-binding PF00249.31 EFA76404.1 - 0.0032 17.6 0.3 0.0093 16.1 0.3 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-C2H2_2 PF12756.7 EFA76405.1 - 2e-36 124.4 23.5 2.3e-19 69.6 1.9 4.0 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFA76405.1 - 0.00034 20.8 5.9 0.00034 20.8 5.9 4.3 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding DUF4187 PF13821.6 EFA76405.1 - 0.017 14.9 5.9 13 5.7 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zf-met PF12874.7 EFA76405.1 - 0.037 14.4 4.1 0.037 14.4 4.1 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type FAM60A PF15396.6 EFA76405.1 - 0.091 12.7 3.5 0.24 11.4 3.4 1.8 1 1 0 1 1 1 0 Protein Family FAM60A zf-C2H2_4 PF13894.6 EFA76405.1 - 0.11 13.4 29.2 0.73 10.8 0.7 6.3 6 0 0 6 6 6 0 C2H2-type zinc finger zf-BED PF02892.15 EFA76405.1 - 0.14 12.2 8.0 0.38 10.8 0.3 3.1 3 0 0 3 3 3 0 BED zinc finger Spt20 PF12090.8 EFA76407.1 - 1.4 8.5 9.4 3.7 7.1 9.4 1.6 1 1 0 1 1 1 0 Spt20 family ASXH PF13919.6 EFA76408.1 - 5.4e-05 23.2 0.1 5.4e-05 23.2 0.1 4.0 4 1 0 4 4 4 2 Asx homology domain Methyltransf_2 PF00891.18 EFA76409.1 - 6.1e-43 146.6 0.0 8.1e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA76409.1 - 2.3e-05 24.3 0.0 5.4e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain TrmB PF01978.19 EFA76409.1 - 0.045 13.6 0.0 1.7 8.6 0.0 2.9 2 1 1 3 3 3 0 Sugar-specific transcriptional regulator TrmB LRR_9 PF14580.6 EFA76411.1 - 1.7e-61 206.8 4.3 3.3e-61 205.8 4.3 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFA76411.1 - 5.4e-09 36.2 14.6 4.6e-06 26.9 1.0 4.8 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA76411.1 - 1.6e-06 27.8 8.0 9.1e-06 25.3 1.1 3.7 2 1 2 4 4 4 2 Leucine rich repeat ANATO PF01821.18 EFA76411.1 - 0.3 12.0 0.7 1.4 9.8 0.1 2.2 2 0 0 2 2 2 0 Anaphylotoxin-like domain BcrAD_BadFG PF01869.20 EFA76412.1 - 6.4e-43 147.2 0.0 7.3e-43 147.0 0.0 1.0 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 EFA76412.1 - 0.022 14.3 0.0 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 ROK family Hydant_A_N PF05378.13 EFA76412.1 - 0.093 12.4 0.1 0.25 11.0 0.1 1.7 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase N-terminal region Epsilon_antitox PF08998.11 EFA76412.1 - 0.16 12.2 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial epsilon antitoxin Nipped-B_C PF12830.7 EFA76413.1 - 2.4e-38 132.0 1.7 2.4e-38 132.0 1.7 4.7 5 1 0 5 5 5 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EFA76413.1 - 1.2e-10 41.5 1.2 6.5e-10 39.1 0.3 3.0 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion SDA1 PF05285.12 EFA76413.1 - 0.0001 21.9 16.2 0.0001 21.9 16.2 4.9 4 1 0 4 4 4 1 SDA1 HEAT_2 PF13646.6 EFA76413.1 - 0.00011 22.5 0.0 0.72 10.3 0.0 2.8 2 0 0 2 2 2 2 HEAT repeats Cnd1 PF12717.7 EFA76413.1 - 0.00013 22.1 0.0 0.00013 22.1 0.0 6.1 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFA76413.1 - 0.0015 18.6 0.0 37 4.9 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat Vac14_Fab1_bd PF12755.7 EFA76413.1 - 0.0019 18.8 0.7 6.5 7.4 0.2 3.7 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region PHD PF00628.29 EFA76413.1 - 0.005 16.7 8.8 0.014 15.3 8.8 1.8 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 EFA76413.1 - 1.4 8.9 4.6 4.7 7.2 4.6 1.9 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Glyco_transf_10 PF00852.19 EFA76415.1 - 3.4e-37 127.9 0.1 6.6e-37 126.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_hydro_18 PF00704.28 EFA76415.1 - 7.3e-20 71.9 1.0 1.2e-19 71.2 1.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_tran_10_N PF17039.5 EFA76415.1 - 0.073 13.5 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Fucosyltransferase, N-terminal Pet191_N PF10203.9 EFA76416.1 - 6e-23 80.9 7.1 7.9e-23 80.5 7.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 EFA76416.1 - 0.0054 16.7 11.0 0.08 13.0 5.6 2.6 1 1 1 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EFA76416.1 - 0.33 11.1 9.3 5.4 7.3 4.7 3.0 2 1 0 2 2 2 0 CHCH domain RPN6_N PF18055.1 EFA76417.1 - 1.3e-25 90.1 0.6 2.3e-23 82.8 0.0 3.0 4 0 0 4 4 4 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EFA76417.1 - 3.6e-20 72.4 1.8 5.2e-19 68.7 0.4 3.0 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 EFA76417.1 - 3e-07 30.1 0.2 6.3e-07 29.0 0.2 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_19 PF14559.6 EFA76417.1 - 0.033 14.7 1.7 8.8 6.9 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat IMPDH PF00478.25 EFA76418.1 - 9.2e-133 442.5 2.9 1.1e-132 442.2 2.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EFA76418.1 - 2.4e-13 50.3 0.1 1.3e-07 31.9 0.0 3.0 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 EFA76418.1 - 7.9e-09 35.3 0.4 5.2e-06 26.1 0.2 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EFA76418.1 - 2.8e-06 26.6 1.6 2e-05 23.8 2.2 2.0 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EFA76418.1 - 0.00074 19.0 1.3 0.0035 16.8 0.1 2.1 1 1 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 EFA76418.1 - 0.00076 18.9 0.1 0.0016 17.8 0.1 1.5 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 EFA76418.1 - 0.014 14.6 0.2 0.029 13.5 0.2 1.5 1 0 0 1 1 1 0 Conserved region in glutamate synthase DUF561 PF04481.12 EFA76418.1 - 0.022 14.0 0.9 0.61 9.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF561) Pkinase_Tyr PF07714.17 EFA76420.1 - 4e-15 55.8 0.0 8e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA76420.1 - 4.2e-09 36.2 0.0 4.2e-09 36.2 0.0 2.4 2 1 1 3 3 3 1 Protein kinase domain MFS_1 PF07690.16 EFA76421.1 - 1.8e-15 56.7 30.0 3.1e-08 32.9 9.0 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EFA76421.1 - 0.00024 20.9 1.0 0.00024 20.9 1.0 3.7 2 2 2 4 4 4 1 Ion channel regulatory protein UNC-93 Mucin PF01456.17 EFA76422.1 - 1.1 9.2 37.1 0.15 12.1 15.7 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein HNF-1_N PF04814.13 EFA76422.1 - 9.5 6.8 28.0 1.2 9.7 7.4 3.2 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus YGGT PF02325.17 EFA76423.1 - 0.16 12.4 0.7 0.66 10.4 0.3 2.3 3 0 0 3 3 3 0 YGGT family LMBR1 PF04791.16 EFA76425.1 - 1.4e-43 149.6 29.0 9.3e-33 113.9 0.4 2.2 1 1 1 2 2 2 2 LMBR1-like membrane protein Methyltransf_23 PF13489.6 EFA76426.1 - 1.8e-17 63.7 0.0 3.5e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA76426.1 - 4.9e-17 62.5 0.0 2.9e-16 60.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA76426.1 - 1.2e-14 54.8 0.0 3.8e-14 53.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA76426.1 - 6.8e-14 51.9 0.2 4.2e-13 49.4 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA76426.1 - 8.9e-13 48.7 0.1 4.5e-12 46.4 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA76426.1 - 3.1e-06 26.7 0.0 1.6e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFA76426.1 - 1e-05 25.2 0.0 2.6e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EFA76426.1 - 1.9e-05 24.0 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_8 PF05148.15 EFA76426.1 - 7.8e-05 22.6 0.1 0.00043 20.2 0.1 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase DUF938 PF06080.12 EFA76426.1 - 0.00087 19.1 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_4 PF02390.17 EFA76426.1 - 0.0011 18.4 4.9 0.0038 16.7 0.0 3.1 3 1 0 3 3 3 1 Putative methyltransferase CheR PF01739.18 EFA76426.1 - 0.0057 16.2 0.1 0.039 13.4 0.0 2.3 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Mucin PF01456.17 EFA76426.1 - 0.0057 16.7 19.4 0.0091 16.0 19.4 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Methyltransf_PK PF05891.12 EFA76426.1 - 0.028 14.0 0.0 0.052 13.1 0.0 1.6 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_24 PF13578.6 EFA76426.1 - 0.16 13.0 0.0 0.49 11.4 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain SSP160 PF06933.11 EFA76426.1 - 6.3 4.9 18.3 8.9 4.4 18.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4419 PF14388.6 EFA76427.1 - 1.9e-94 316.5 2.8 2.9e-94 315.9 2.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) LRR_4 PF12799.7 EFA76428.1 - 0.0032 17.8 5.5 0.39 11.2 0.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) TIG PF01833.24 EFA76429.1 - 0.00057 19.9 3.6 0.00057 19.9 3.6 2.7 3 0 0 3 3 3 1 IPT/TIG domain MHC2-interact PF09307.10 EFA76429.1 - 0.0026 17.7 0.8 0.072 13.1 0.4 2.3 2 0 0 2 2 2 1 CLIP, MHC2 interacting UPF0542 PF15086.6 EFA76429.1 - 0.0094 15.9 0.4 0.023 14.6 0.4 1.6 1 0 0 1 1 1 1 Uncharacterised protein family UPF0542 DUF5305 PF17231.2 EFA76429.1 - 0.012 15.0 0.3 0.029 13.8 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) EB PF01683.18 EFA76429.1 - 0.017 15.4 3.7 0.041 14.2 3.7 1.6 1 0 0 1 1 1 0 EB module DUF2561 PF10812.8 EFA76429.1 - 0.017 15.1 0.1 0.029 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) MpPF26 PF07666.11 EFA76429.1 - 0.022 14.9 0.3 0.055 13.6 0.3 1.6 1 0 0 1 1 1 0 M penetrans paralogue family 26 EGF_2 PF07974.13 EFA76429.1 - 0.11 12.9 14.7 0.31 11.4 14.7 1.8 1 0 0 1 1 1 0 EGF-like domain SP_C-Propep PF08999.10 EFA76429.1 - 0.13 12.1 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide YajC PF02699.15 EFA76429.1 - 0.15 12.0 2.4 0.52 10.2 1.7 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit WD40 PF00400.32 EFA76430.1 - 3.4e-23 81.5 2.7 2.7e-05 24.9 0.2 6.9 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76430.1 - 6.9e-06 26.3 0.0 0.58 10.5 0.0 4.3 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA76430.1 - 0.021 14.7 0.7 1.4 8.7 0.0 2.9 2 2 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 EFA76430.1 - 0.13 11.9 0.0 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 PQQ-like domain Pyr_redox_2 PF07992.14 EFA76432.1 - 2.3e-15 56.6 0.0 3.4e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFA76432.1 - 0.0062 15.4 0.4 0.012 14.5 0.4 1.5 1 0 0 1 1 1 1 Tryptophan halogenase DAO PF01266.24 EFA76432.1 - 0.0077 15.8 0.2 0.02 14.5 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA76432.1 - 0.021 15.1 0.3 0.054 13.7 0.3 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFA76432.1 - 0.033 13.4 2.7 4 6.6 0.1 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EFA76432.1 - 0.037 14.3 0.0 0.073 13.3 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 EFA76432.1 - 0.043 13.8 1.0 4.9 7.1 0.2 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding Stap_Strp_tox_C PF02876.17 EFA76432.1 - 0.072 13.4 0.1 0.19 12.0 0.1 1.7 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain REGB_T4 PF10715.9 EFA76432.1 - 0.09 13.0 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 T4-page Endoribonuclease RegB HI0933_like PF03486.14 EFA76432.1 - 0.096 11.4 0.3 0.96 8.1 0.2 2.4 3 0 0 3 3 3 0 HI0933-like protein FAD_binding_3 PF01494.19 EFA76432.1 - 0.11 11.7 0.1 0.27 10.5 0.1 1.5 2 0 0 2 2 2 0 FAD binding domain HTH_psq PF05225.16 EFA76434.1 - 4.9e-05 23.0 0.0 7.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_3 PF01381.22 EFA76434.1 - 0.00051 20.1 0.2 0.21 11.7 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix HTH_24 PF13412.6 EFA76434.1 - 0.0043 16.6 0.1 0.33 10.6 0.0 2.3 1 1 1 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_37 PF13744.6 EFA76434.1 - 0.0058 16.6 1.0 0.011 15.7 0.2 1.9 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_AsnC-type PF13404.6 EFA76434.1 - 0.0068 16.2 0.0 0.067 13.0 0.0 2.0 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain Sigma70_r4 PF04545.16 EFA76434.1 - 0.027 14.0 0.4 3.4 7.3 0.0 2.3 1 1 1 2 2 2 0 Sigma-70, region 4 HTH_Crp_2 PF13545.6 EFA76434.1 - 0.045 13.7 0.1 4.4 7.4 0.0 2.6 2 1 1 3 3 3 0 Crp-like helix-turn-helix domain HTH_26 PF13443.6 EFA76434.1 - 0.05 14.0 0.1 0.56 10.7 0.0 2.2 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain IL12 PF03039.14 EFA76434.1 - 0.063 12.6 0.4 0.099 12.0 0.3 1.4 1 1 0 1 1 1 0 Interleukin-12 alpha subunit RMI1_C PF16099.5 EFA76434.1 - 0.068 13.0 0.5 0.1 12.4 0.5 1.4 1 1 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold HTH_10 PF04967.12 EFA76434.1 - 0.1 12.4 0.1 20 5.1 0.0 2.6 2 1 0 2 2 2 0 HTH DNA binding domain CENP-B_N PF04218.13 EFA76434.1 - 0.14 11.8 0.3 0.14 11.8 0.3 2.4 1 1 2 3 3 3 0 CENP-B N-terminal DNA-binding domain HTH_19 PF12844.7 EFA76434.1 - 0.16 12.0 1.7 0.58 10.2 0.3 2.3 2 1 0 2 2 2 0 Helix-turn-helix domain DUF1980 PF09323.10 EFA76434.1 - 0.17 11.8 1.1 0.21 11.5 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Nsp1_C PF05064.13 EFA76435.1 - 0.017 14.9 0.2 0.052 13.4 0.1 1.8 2 0 0 2 2 2 0 Nsp1-like C-terminal region F-box-like PF12937.7 EFA76437.1 - 0.0063 16.4 0.0 0.027 14.3 0.0 2.2 1 0 0 1 1 1 1 F-box-like Ephrin PF00812.17 EFA76441.1 - 0.0039 17.2 0.3 0.0064 16.5 0.3 1.3 1 0 0 1 1 1 1 Ephrin K1 PF02960.14 EFA76441.1 - 0.039 14.1 0.3 0.039 14.1 0.3 1.5 2 0 0 2 2 2 0 K1 glycoprotein DUF3551 PF12071.8 EFA76441.1 - 9.5 6.4 11.2 15 5.7 1.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3551) RNA_pol_Rpb4 PF03874.16 EFA76442.1 - 1.5e-14 54.4 3.4 7.4e-14 52.1 3.4 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb4 NA37 PF04245.13 EFA76442.1 - 0.025 14.0 0.6 0.028 13.9 0.6 1.2 1 1 0 1 1 1 0 37-kD nucleoid-associated bacterial protein tRNA-synt_1e PF01406.19 EFA76443.1 - 2.2e-132 441.0 0.2 4.1e-132 440.1 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFA76443.1 - 9.6e-13 47.6 1.4 4.8e-06 25.6 0.1 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EFA76443.1 - 0.0023 18.4 0.1 0.0023 18.4 0.1 2.1 2 0 0 2 2 2 1 DALR domain tRNA-synt_1 PF00133.22 EFA76443.1 - 0.005 15.2 0.0 0.005 15.2 0.0 3.0 3 1 1 4 4 4 1 tRNA synthetases class I (I, L, M and V) AAA-ATPase_like PF09820.9 EFA76443.1 - 0.007 15.8 0.4 0.007 15.8 0.4 2.0 2 1 0 2 2 2 1 Predicted AAA-ATPase tRNA-synt_1c PF00749.21 EFA76443.1 - 0.024 13.5 1.5 0.036 13.0 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUP PF00674.18 EFA76443.1 - 0.049 13.8 0.1 0.12 12.6 0.1 1.7 1 0 0 1 1 1 0 DUP family WD40 PF00400.32 EFA76444.1 - 9.1e-17 61.1 12.7 0.00011 22.9 0.5 6.6 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76444.1 - 4.2e-08 33.4 0.6 0.072 13.4 0.0 4.7 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA76444.1 - 1.8e-05 24.8 0.6 0.03 14.2 0.1 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PAP1 PF08601.10 EFA76444.1 - 0.0028 17.4 17.3 0.0042 16.9 17.3 1.2 1 0 0 1 1 1 1 Transcription factor PAP1 DUF4643 PF15485.6 EFA76444.1 - 4 7.2 15.4 6.6 6.5 15.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4643) DUF3446 PF11928.8 EFA76444.1 - 4.1 7.8 31.9 3.9 7.8 9.1 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain SWI-SNF_Ssr4 PF08549.10 EFA76444.1 - 4.7 5.7 11.3 6.9 5.2 11.3 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Aminotran_3 PF00202.21 EFA76445.1 - 2.6e-78 263.5 0.0 3.4e-78 263.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFA76445.1 - 0.012 14.8 0.0 0.51 9.4 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class I and II Topoisom_I_N PF02919.15 EFA76447.1 - 2.4e-92 308.3 4.6 2.4e-92 308.3 4.6 4.4 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 EFA76447.1 - 5.8e-92 307.1 3.6 5.8e-92 307.1 3.6 3.4 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 EFA76447.1 - 3.3e-34 116.6 0.3 1.8e-33 114.3 0.3 2.4 1 0 0 1 1 1 1 C-terminal topoisomerase domain AMP-binding PF00501.28 EFA76449.1 - 5.4e-88 295.4 1.2 2.1e-86 290.2 1.2 2.0 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA76449.1 - 2.8e-18 66.7 0.0 5.9e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF3430 PF11912.8 EFA76450.1 - 1.7e-09 38.1 22.9 1.9e-09 37.9 22.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) adh_short PF00106.25 EFA76453.1 - 3.6e-48 163.6 0.0 4.5e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76453.1 - 3.2e-30 105.4 0.0 4.3e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76453.1 - 8.7e-15 55.1 0.0 1.3e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA76453.1 - 2.3e-07 30.5 0.0 4.3e-07 29.7 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EFA76453.1 - 5.1e-05 22.7 0.1 9.5e-05 21.8 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Polysacc_synt_2 PF02719.15 EFA76453.1 - 0.00011 21.4 0.1 0.00014 21.2 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.6 EFA76453.1 - 0.00014 22.2 0.1 0.00027 21.3 0.1 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 EFA76453.1 - 0.00031 21.0 0.1 0.00049 20.4 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFA76453.1 - 0.00071 19.7 0.2 0.0012 18.9 0.2 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 EFA76453.1 - 0.00085 18.8 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFA76453.1 - 0.0014 18.5 0.0 0.0046 16.9 0.0 1.8 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFA76453.1 - 0.0025 16.8 1.2 0.0044 16.1 1.2 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family FANCI_S3 PF14677.6 EFA76453.1 - 0.0095 15.7 0.3 0.015 15.0 0.3 1.2 1 0 0 1 1 1 1 FANCI solenoid 3 TPR_MLP1_2 PF07926.12 EFA76453.1 - 0.022 14.8 0.1 0.033 14.2 0.1 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein RsgA_GTPase PF03193.16 EFA76453.1 - 0.056 13.4 0.2 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 RsgA GTPase Y_phosphatase PF00102.27 EFA76454.1 - 1.2e-79 267.2 2.7 1.2e-79 267.2 2.7 2.4 2 1 1 3 3 3 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFA76454.1 - 0.00018 21.3 0.0 0.00018 21.3 0.0 3.1 2 1 0 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFA76454.1 - 0.00029 21.0 0.1 0.00029 21.0 0.1 3.0 2 2 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFA76454.1 - 0.00053 20.0 0.0 0.0015 18.6 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF5540 PF17694.1 EFA76454.1 - 0.011 16.2 2.2 0.011 16.2 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5540) Mucin PF01456.17 EFA76454.1 - 0.74 9.8 18.4 1.8 8.6 18.4 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4407 PF14362.6 EFA76454.1 - 0.74 9.1 4.1 1 8.6 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MPM1 PF17234.2 EFA76454.1 - 2.8 8.2 14.5 6.6 7.0 14.5 1.6 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Androgen_recep PF02166.16 EFA76454.1 - 3.7 6.3 14.2 4.9 5.9 14.2 1.1 1 0 0 1 1 1 0 Androgen receptor PAP1 PF08601.10 EFA76454.1 - 3.9 7.1 26.4 6.9 6.3 26.4 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 NDUF_B7 PF05676.13 EFA76456.1 - 0.00011 21.8 0.6 0.00018 21.1 0.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 EFA76456.1 - 0.01 15.8 1.0 0.015 15.3 1.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Proteasom_PSMB PF10508.9 EFA76456.1 - 0.038 12.5 0.2 0.038 12.5 0.2 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit DUF2655 PF10848.8 EFA76456.1 - 0.08 13.3 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2655) DUF4024 PF13216.6 EFA76456.1 - 2.6 8.1 5.5 14 5.7 5.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4024) PP28 PF10252.9 EFA76457.1 - 1.6e-12 47.7 16.9 1.6e-12 47.7 16.9 2.9 2 2 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 AF-4 PF05110.13 EFA76457.1 - 0.12 10.5 21.3 0.13 10.3 21.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Nop53 PF07767.11 EFA76457.1 - 0.16 11.3 41.8 0.18 11.1 41.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SOBP PF15279.6 EFA76457.1 - 1 9.9 12.8 1.3 9.6 12.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein HSP70 PF00012.20 EFA76458.1 - 5.7e-91 305.5 5.1 2.4e-85 286.9 0.1 3.6 4 0 0 4 4 4 2 Hsp70 protein MreB_Mbl PF06723.13 EFA76458.1 - 1.7e-05 23.8 0.0 0.00014 20.8 0.0 2.3 2 1 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFA76458.1 - 0.00095 18.5 0.1 0.92 8.7 0.0 2.8 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase ABC_membrane PF00664.23 EFA76459.1 - 8.5e-130 432.3 24.9 3.7e-68 230.1 6.6 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA76459.1 - 3e-70 235.1 0.0 1.1e-33 116.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA76459.1 - 2e-13 50.3 3.6 9.6e-06 25.2 0.1 3.3 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EFA76459.1 - 7.1e-09 35.0 0.6 0.00064 18.6 0.1 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EFA76459.1 - 6.9e-06 25.7 0.6 0.11 12.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA76459.1 - 1.6e-05 25.2 0.1 0.47 10.7 0.1 3.1 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFA76459.1 - 1.8e-05 24.7 0.0 0.15 11.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 EFA76459.1 - 6.1e-05 23.2 2.7 0.26 11.5 0.3 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EFA76459.1 - 0.00074 19.9 0.2 0.85 10.0 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EFA76459.1 - 0.0019 18.0 2.6 2.7 7.7 0.4 3.8 2 2 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EFA76459.1 - 0.002 17.7 0.0 1.8 8.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 EFA76459.1 - 0.02 14.9 0.7 23 5.0 0.0 4.2 4 1 0 4 4 4 0 AAA domain (dynein-related subfamily) CDC45 PF02724.14 EFA76459.1 - 0.02 13.2 0.1 0.038 12.3 0.1 1.4 1 0 0 1 1 1 0 CDC45-like protein AAA_25 PF13481.6 EFA76459.1 - 0.032 13.8 0.0 2.3 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Smg8_Smg9 PF10220.9 EFA76459.1 - 0.034 12.5 0.5 0.051 11.9 0.5 1.1 1 0 0 1 1 1 0 Smg8_Smg9 AAA_21 PF13304.6 EFA76459.1 - 0.04 13.7 0.3 16 5.2 0.1 3.4 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Phage_T4_Ndd PF06591.11 EFA76459.1 - 0.082 12.7 0.0 8.3 6.2 0.0 2.4 2 0 0 2 2 2 0 T4-like phage nuclear disruption protein (Ndd) Roc PF08477.13 EFA76459.1 - 0.11 12.7 0.3 18 5.5 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EFA76459.1 - 0.11 12.2 4.0 21 4.8 0.1 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_18 PF13238.6 EFA76459.1 - 0.12 12.9 0.0 25 5.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA76461.1 - 4.6e-70 234.5 0.0 1.4e-33 116.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFA76461.1 - 1.2e-62 212.1 8.0 2.1e-62 211.3 8.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EFA76461.1 - 2e-15 56.9 0.0 3.6e-06 26.6 0.2 3.3 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EFA76461.1 - 2.9e-09 36.3 0.7 0.0003 19.7 0.1 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EFA76461.1 - 9.8e-06 25.6 0.0 0.13 12.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 EFA76461.1 - 1.5e-05 25.1 2.9 0.13 12.6 0.2 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFA76461.1 - 1.7e-05 24.5 3.1 0.073 12.8 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA76461.1 - 1.7e-05 25.1 0.3 0.28 11.5 0.0 3.2 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA76461.1 - 0.00067 20.1 0.8 0.86 10.0 0.1 2.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EFA76461.1 - 0.0018 17.8 0.0 1.9 8.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF3487 PF11990.8 EFA76461.1 - 0.0042 17.0 0.9 0.38 10.7 2.2 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3487) AAA_5 PF07728.14 EFA76461.1 - 0.0064 16.5 1.1 14 5.7 0.0 4.4 4 1 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFA76461.1 - 0.019 14.6 0.0 1.3 8.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EFA76461.1 - 0.021 14.6 0.5 13 5.4 0.1 3.7 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 EFA76461.1 - 0.038 13.7 3.6 16 5.2 0.1 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_18 PF13238.6 EFA76461.1 - 0.049 14.2 0.0 15 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFA76461.1 - 0.058 13.1 8.8 2.5 7.8 0.3 3.9 3 2 0 3 3 2 0 AAA domain DUF815 PF05673.13 EFA76461.1 - 0.085 12.0 0.1 3.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 EFA76461.1 - 0.092 13.0 0.2 14 5.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Phage_T4_Ndd PF06591.11 EFA76461.1 - 0.13 12.1 0.0 18 5.1 0.0 2.4 2 0 0 2 2 2 0 T4-like phage nuclear disruption protein (Ndd) Coilin_N PF15862.5 EFA76461.1 - 0.35 10.7 4.1 0.79 9.5 4.1 1.5 1 0 0 1 1 1 0 Coilin N-terminus DUF2057 PF09829.9 EFA76461.1 - 0.42 10.8 7.7 3.6 7.7 0.1 3.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2057) SR-25 PF10500.9 EFA76461.1 - 0.48 10.0 14.4 0.61 9.7 13.0 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MFMR_assoc PF16596.5 EFA76461.1 - 1.9 9.0 11.9 4 7.9 11.9 1.5 1 0 0 1 1 1 0 Disordered region downstream of MFMR TruB_C PF09142.11 EFA76461.1 - 2.9 7.7 4.4 21 5.0 0.1 3.0 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal ABC_membrane PF00664.23 EFA76462.1 - 1.8e-68 231.2 5.6 2.1e-68 230.9 5.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF2207 PF09972.9 EFA76462.1 - 0.61 8.8 9.7 0.68 8.6 6.9 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Rgp1 PF08737.10 EFA76463.1 - 2.9e-32 112.4 9.9 1.3e-21 77.3 1.0 4.0 2 1 1 4 4 4 2 Rgp1 TFIIA PF03153.13 EFA76463.1 - 0.017 15.1 28.8 0.088 12.8 11.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Herpes_LMP1 PF05297.11 EFA76463.1 - 0.1 11.8 5.0 0.16 11.2 5.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Suf PF05843.14 EFA76463.1 - 1.4 8.9 22.9 0.41 10.6 3.9 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) ABC_tran PF00005.27 EFA76464.1 - 2.5e-44 151.1 4.9 3.2e-21 76.3 0.0 3.6 4 0 0 4 4 4 2 ABC transporter ABC_tran_Xtn PF12848.7 EFA76464.1 - 6.4e-26 90.2 4.8 6.4e-26 90.2 4.8 3.3 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 EFA76464.1 - 1.5e-15 57.8 3.0 0.0016 18.3 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFA76464.1 - 8.3e-08 32.8 0.9 0.06 13.9 0.0 4.4 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 EFA76464.1 - 8.6e-08 32.7 0.7 0.0032 17.9 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain NACHT PF05729.12 EFA76464.1 - 6e-07 29.5 0.1 0.023 14.6 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.6 EFA76464.1 - 7.7e-07 29.1 1.0 0.062 13.0 0.2 3.7 3 1 0 3 3 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFA76464.1 - 8.8e-07 29.0 0.9 0.026 14.6 0.1 3.8 4 0 0 4 4 3 2 50S ribosome-binding GTPase AAA PF00004.29 EFA76464.1 - 9e-07 29.4 0.0 0.033 14.6 0.0 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EFA76464.1 - 1.4e-06 29.0 10.1 0.11 13.0 0.0 4.6 3 1 0 3 3 3 2 AAA domain SMC_N PF02463.19 EFA76464.1 - 1.7e-06 27.6 1.2 0.00016 21.2 1.1 3.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFA76464.1 - 5.7e-06 26.3 1.2 0.071 13.0 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_28 PF13521.6 EFA76464.1 - 9e-06 26.0 2.7 0.065 13.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EFA76464.1 - 2e-05 24.2 0.1 0.12 12.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA76464.1 - 2.6e-05 24.5 1.0 0.24 11.6 0.1 3.0 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFA76464.1 - 5e-05 23.3 0.4 0.34 10.9 0.2 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Roc PF08477.13 EFA76464.1 - 5.2e-05 23.5 0.8 0.82 9.9 0.0 3.5 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EFA76464.1 - 6.3e-05 22.8 0.0 0.33 10.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EFA76464.1 - 0.00016 21.4 0.0 1 9.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EFA76464.1 - 0.00019 20.7 0.1 0.44 9.7 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain PduV-EutP PF10662.9 EFA76464.1 - 0.00039 20.2 1.6 0.52 10.1 0.0 3.3 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation MobB PF03205.14 EFA76464.1 - 0.0005 20.0 0.1 0.88 9.5 0.0 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.19 EFA76464.1 - 0.00054 19.6 0.6 0.47 10.0 0.0 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 EFA76464.1 - 0.00093 19.2 2.9 2.5 8.1 0.0 4.3 6 0 0 6 6 3 2 AAA domain RNA_helicase PF00910.22 EFA76464.1 - 0.0011 19.3 0.0 0.96 9.9 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 EFA76464.1 - 0.0011 18.5 0.1 1.6 8.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF3584 PF12128.8 EFA76464.1 - 0.0013 16.3 0.1 0.0013 16.3 0.1 3.8 5 0 0 5 5 5 1 Protein of unknown function (DUF3584) TsaE PF02367.17 EFA76464.1 - 0.0015 18.6 0.5 1.5 8.8 0.1 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EFA76464.1 - 0.0019 18.2 0.2 0.62 10.0 0.0 2.9 2 0 0 2 2 2 1 NTPase AAA_25 PF13481.6 EFA76464.1 - 0.0024 17.5 0.2 0.83 9.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 EFA76464.1 - 0.0027 17.6 2.7 0.092 12.6 0.0 3.1 4 0 0 4 4 3 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EFA76464.1 - 0.0029 17.9 0.1 3.1 8.1 0.1 2.9 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EFA76464.1 - 0.0037 16.9 0.6 1.4 8.5 0.0 3.0 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain FeoB_N PF02421.18 EFA76464.1 - 0.0053 16.3 0.5 1.4 8.4 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B AAA_33 PF13671.6 EFA76464.1 - 0.0056 16.9 14.1 0.026 14.7 0.0 4.0 4 1 0 4 4 3 2 AAA domain T2SSE PF00437.20 EFA76464.1 - 0.045 12.8 0.9 4.2 6.4 0.0 2.6 2 1 0 2 2 2 0 Type II/IV secretion system protein Rop PF01815.16 EFA76464.1 - 0.093 12.6 0.6 7.5 6.5 0.0 3.3 3 0 0 3 3 3 0 Rop protein RuvB_N PF05496.12 EFA76464.1 - 0.11 12.2 0.2 7.7 6.2 0.0 3.1 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain ATP-synt_ab PF00006.25 EFA76464.1 - 0.12 12.0 0.1 17 4.9 0.0 2.7 3 1 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_13 PF13166.6 EFA76464.1 - 0.13 10.9 0.0 0.13 10.9 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_17 PF13207.6 EFA76464.1 - 0.4 11.1 3.6 63 4.0 0.0 4.0 3 1 0 3 3 3 0 AAA domain ZnuA PF01297.17 EFA76464.1 - 6.3 6.1 8.5 0.76 9.1 0.4 2.4 3 0 0 3 3 2 0 Zinc-uptake complex component A periplasmic LRR_6 PF13516.6 EFA76465.1 - 1.4e-11 43.4 30.6 0.027 14.5 0.1 10.4 12 0 0 12 12 12 4 Leucine Rich repeat LRR_4 PF12799.7 EFA76465.1 - 5.3e-07 29.9 25.9 0.084 13.3 0.1 7.5 7 1 1 8 8 8 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA76465.1 - 1.1e-05 25.1 24.3 0.16 11.7 0.5 8.3 7 3 1 8 8 8 4 Leucine rich repeat LRR_1 PF00560.33 EFA76465.1 - 0.00053 20.2 29.8 17 6.4 0.0 11.0 11 1 0 11 11 11 2 Leucine Rich Repeat Carm_PH PF17888.1 EFA76465.1 - 0.00059 20.1 0.2 0.0015 18.8 0.2 1.6 1 0 0 1 1 1 1 Carmil pleckstrin homology domain adh_short PF00106.25 EFA76466.1 - 1.1e-48 165.2 0.1 1.5e-48 164.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76466.1 - 2.1e-29 102.7 0.0 2.8e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76466.1 - 1.3e-08 35.0 0.0 3.7e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EFA76466.1 - 5.9e-07 29.2 0.0 9.5e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA76466.1 - 1.9e-06 27.9 0.0 3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFA76466.1 - 0.0015 17.6 0.7 0.0032 16.5 0.7 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFA76466.1 - 0.0083 15.6 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EFA76466.1 - 0.0083 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family QRPTase_C PF01729.19 EFA76466.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain RRM_1 PF00076.22 EFA76467.1 - 6.2e-15 54.8 0.0 1.3e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA76467.1 - 0.002 17.7 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 EFA76467.1 - 0.016 15.8 9.8 0.036 14.7 9.8 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term PDEase_II PF02112.15 EFA76468.1 - 1e-78 264.8 0.1 1e-78 264.8 0.1 2.1 2 0 0 2 2 2 1 cAMP phosphodiesterases class-II Dicty_CTDC PF00526.18 EFA76469.1 - 2.3e-114 372.7 312.5 3.2e-10 39.7 9.3 17.1 17 0 0 17 17 17 16 Dictyostelium (slime mold) repeat HOK_GEF PF01848.16 EFA76469.1 - 0.072 12.5 0.4 0.14 11.6 0.4 1.4 1 0 0 1 1 1 0 Hok/gef family Vault_2 PF17794.1 EFA76469.1 - 0.39 11.1 10.4 54 4.3 0.1 5.3 3 2 2 5 5 5 0 Major Vault Protein repeat domain adh_short PF00106.25 EFA76470.1 - 2.5e-47 160.9 0.1 3.1e-47 160.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76470.1 - 3.6e-31 108.5 0.0 4.7e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76470.1 - 9.1e-09 35.5 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA76470.1 - 8.1e-05 22.2 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA76470.1 - 0.001 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EFA76470.1 - 0.0063 15.9 0.5 0.0086 15.5 0.0 1.5 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EFA76470.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family GDP_Man_Dehyd PF16363.5 EFA76470.1 - 0.076 12.4 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EFA76471.1 - 6.6e-49 166.0 0.9 8.1e-49 165.7 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76471.1 - 1.2e-32 113.4 0.3 1.5e-32 113.0 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76471.1 - 1.3e-08 35.0 0.1 2e-08 34.3 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA76471.1 - 4.3e-05 23.1 0.0 5.4e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA76471.1 - 4.4e-05 23.4 0.0 0.00011 22.1 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EFA76471.1 - 0.00059 19.5 0.1 0.00099 18.7 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EFA76471.1 - 0.00062 20.0 0.1 0.00096 19.4 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 EFA76471.1 - 0.0044 16.1 0.1 0.0063 15.6 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RRF PF01765.19 EFA76471.1 - 0.0061 16.5 0.5 0.026 14.5 0.3 1.9 2 0 0 2 2 2 1 Ribosome recycling factor QRPTase_C PF01729.19 EFA76471.1 - 0.013 15.3 0.1 0.025 14.4 0.1 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Chlam_PMP PF02415.17 EFA76472.1 - 0.1 13.1 47.8 3.4 8.4 0.3 10.2 12 0 0 12 12 12 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat LktC PF06261.11 EFA76472.1 - 0.18 11.7 0.1 0.47 10.4 0.0 1.7 2 0 0 2 2 2 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC Methyltr_RsmB-F PF01189.17 EFA76473.1 - 1.2e-23 83.9 0.3 7.1e-14 51.9 0.1 2.8 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EFA76473.1 - 0.032 14.3 0.0 0.075 13.1 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF572 PF04502.13 EFA76473.1 - 2.4 7.7 41.8 0.76 9.3 1.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) Sec62 PF03839.16 EFA76474.1 - 7.7 6.0 7.8 19 4.7 7.8 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 XPG_N PF00752.17 EFA76475.1 - 1.3e-25 89.8 0.0 2.3e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EFA76475.1 - 1.3e-16 60.7 0.2 3.4e-16 59.4 0.1 1.8 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 EFA76475.1 - 7e-07 29.0 0.0 8.1e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 EFA76475.1 - 0.0019 18.2 0.0 0.0036 17.3 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat 5_3_exonuc PF01367.20 EFA76476.1 - 0.0047 17.5 0.0 0.016 15.8 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Ion_trans PF00520.31 EFA76477.1 - 7.8e-09 35.1 1.4 7.8e-09 35.1 1.4 2.2 2 0 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 EFA76477.1 - 8.9e-06 24.6 0.9 8.9e-06 24.6 0.9 1.7 2 0 0 2 2 2 1 Polycystin cation channel Dehydrin PF00257.19 EFA76477.1 - 0.8 10.2 4.7 0.45 11.0 1.4 2.0 2 0 0 2 2 2 0 Dehydrin DUF4834 PF16118.5 EFA76477.1 - 3.6 8.6 8.6 2.7 9.0 0.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Tyr_Deacylase PF02580.16 EFA76478.1 - 6.3e-46 156.5 0.1 1.1e-45 155.7 0.1 1.3 1 1 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase IF-2B PF01008.17 EFA76479.1 - 1.6e-73 247.3 0.0 2.2e-73 246.9 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ras PF00071.22 EFA76480.1 - 6.3e-35 120.2 0.2 7.6e-35 119.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA76480.1 - 6.1e-26 91.0 0.1 9.3e-26 90.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA76480.1 - 2.7e-08 33.5 0.1 3.1e-08 33.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA76480.1 - 3.7e-06 26.5 0.2 4.7e-06 26.1 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 EFA76480.1 - 0.0057 15.6 0.4 1.7 7.4 0.1 2.0 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) G-alpha PF00503.20 EFA76480.1 - 0.0087 15.2 1.6 0.07 12.3 0.2 2.4 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.9 EFA76480.1 - 0.031 14.0 0.3 0.071 12.8 0.3 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFA76480.1 - 0.069 12.6 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NadA PF02445.16 EFA76480.1 - 0.096 11.8 0.1 8.3 5.5 0.0 2.1 2 0 0 2 2 2 0 Quinolinate synthetase A protein MMR_HSR1 PF01926.23 EFA76480.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 EFA76480.1 - 0.18 11.2 0.0 1.5 8.2 0.0 2.2 2 1 1 3 3 3 0 Bacterial TniB protein Pkinase PF00069.25 EFA76481.1 - 3.6e-61 206.8 0.0 5.9e-61 206.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76481.1 - 4.3e-48 163.8 0.0 6.6e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA76481.1 - 0.0028 16.5 0.0 0.0028 16.5 0.0 2.7 2 1 0 2 2 2 1 Fungal protein kinase DUF908 PF06012.12 EFA76481.1 - 0.0039 16.7 11.9 1.6 8.1 13.7 2.4 2 0 0 2 2 2 2 Domain of Unknown Function (DUF908) TFIIA PF03153.13 EFA76481.1 - 0.32 11.0 23.5 0.54 10.2 23.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LIM PF00412.22 EFA76482.1 - 2.3e-28 98.2 38.6 7.1e-11 42.2 7.1 3.4 3 0 0 3 3 3 3 LIM domain WH2 PF02205.20 EFA76482.1 - 7.9e-10 38.3 0.7 2.3e-09 36.8 0.4 2.0 2 0 0 2 2 2 1 WH2 motif Sec3-PIP2_bind PF15277.6 EFA76482.1 - 0.17 12.0 0.0 0.49 10.5 0.0 1.7 2 0 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH PhyH PF05721.13 EFA76484.1 - 2.6e-06 27.8 0.1 0.00016 22.0 0.0 2.8 3 0 0 3 3 3 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFA76484.1 - 8.1e-05 21.6 0.5 0.12 11.2 0.1 3.2 3 1 0 3 3 3 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.6 EFA76484.1 - 0.055 14.4 0.0 0.11 13.3 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PBP1_TM PF14812.6 EFA76484.1 - 0.081 13.3 5.8 0.18 12.2 5.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EFA76484.1 - 0.19 12.1 9.0 0.4 11.1 9.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFA76484.1 - 0.31 10.7 5.1 0.57 9.8 5.1 1.4 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 EFA76484.1 - 0.4 10.7 10.6 0.72 9.9 10.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal XRCC4 PF06632.12 EFA76484.1 - 0.51 9.1 10.6 0.37 9.6 9.1 1.4 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Cwf_Cwc_15 PF04889.12 EFA76484.1 - 0.54 10.0 14.7 0.79 9.4 14.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2076 PF09849.9 EFA76484.1 - 4.5 7.2 9.4 7 6.6 9.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PPL5 PF18168.1 EFA76484.1 - 9.8 5.4 8.6 15 4.8 8.6 1.2 1 0 0 1 1 1 0 Prim-pol family 5 GMAP PF06540.11 EFA76485.1 - 0.015 15.3 0.0 3.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Galanin message associated peptide (GMAP) Nsp1_C PF05064.13 EFA76486.1 - 0.1 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Nsp1-like C-terminal region SUIM_assoc PF16619.5 EFA76488.1 - 0.071 13.2 6.6 0.27 11.3 6.6 2.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF3533 PF12051.8 EFA76488.1 - 0.32 9.9 1.7 0.66 8.8 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) ELMO_CED12 PF04727.13 EFA76489.1 - 3e-33 115.4 0.8 3e-33 115.4 0.8 2.7 2 0 0 2 2 2 1 ELMO/CED-12 family FRG1 PF06229.12 EFA76489.1 - 0.042 13.5 1.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 0 FRG1-like domain ArfGap PF01412.18 EFA76490.1 - 8.9e-40 135.4 0.2 8.9e-40 135.4 0.2 2.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EFA76490.1 - 4.8e-19 69.0 10.5 4.8e-19 69.0 10.5 2.0 2 0 0 2 2 2 1 BAR domain of APPL family PH PF00169.29 EFA76490.1 - 1.2e-16 61.1 0.1 1.2e-16 61.1 0.1 2.3 2 0 0 2 2 2 1 PH domain Ank_4 PF13637.6 EFA76490.1 - 4.9e-13 49.3 0.0 5.7e-08 33.2 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA76490.1 - 9.5e-09 35.7 0.0 3.8e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA76490.1 - 5.3e-08 33.0 0.1 3e-07 30.6 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) BAR PF03114.18 EFA76490.1 - 5e-07 29.6 7.5 1.3e-06 28.3 7.5 1.7 1 0 0 1 1 1 1 BAR domain Ank PF00023.30 EFA76490.1 - 1.2e-05 25.5 0.0 0.057 13.9 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat PH_11 PF15413.6 EFA76490.1 - 0.00056 20.3 0.0 0.00056 20.3 0.0 3.5 4 0 0 4 4 3 1 Pleckstrin homology domain Ank_3 PF13606.6 EFA76490.1 - 0.0057 17.1 0.0 0.43 11.3 0.0 3.6 4 0 0 4 4 3 1 Ankyrin repeat PH_9 PF15410.6 EFA76490.1 - 0.0095 16.3 1.2 0.08 13.3 0.0 3.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 EFA76490.1 - 0.01 15.6 0.1 0.05 13.4 0.1 2.2 1 0 0 1 1 1 0 Pleckstrin homology domain CCDC-167 PF15188.6 EFA76490.1 - 0.087 13.2 3.0 0.31 11.4 3.0 1.9 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Arm PF00514.23 EFA76493.1 - 4.6e-14 51.9 4.2 0.001 19.1 0.0 7.6 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 EFA76493.1 - 2.8e-09 36.9 25.9 0.01 15.9 0.1 6.8 3 2 6 9 9 9 5 Spinocerebellar ataxia type 10 protein domain F-box-like PF12937.7 EFA76493.1 - 3.4e-06 26.9 2.2 3.5e-06 26.8 0.4 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA76493.1 - 0.00064 19.5 0.3 0.0021 17.9 0.3 1.8 1 0 0 1 1 1 1 F-box domain STI1 PF17830.1 EFA76493.1 - 1.2 9.1 7.8 1 9.4 1.2 3.4 4 0 0 4 4 4 0 STI1 domain Suf PF05843.14 EFA76494.1 - 0.017 15.1 13.3 0.68 9.9 7.0 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Tyrosinase PF00264.20 EFA76494.1 - 0.027 14.8 13.6 0.072 13.4 7.9 2.2 2 0 0 2 2 2 0 Common central domain of tyrosinase STAC2_u1 PF16664.5 EFA76494.1 - 0.34 11.4 0.1 0.34 11.4 0.1 2.3 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Presenilin PF01080.17 EFA76494.1 - 0.48 9.1 16.3 1.6 7.4 10.4 2.1 2 0 0 2 2 2 0 Presenilin TCP PF03634.13 EFA76494.1 - 0.62 10.6 16.8 4.1 7.9 1.0 2.5 2 0 0 2 2 2 0 TCP family transcription factor RP-C_C PF11800.8 EFA76494.1 - 0.99 9.5 9.6 5.8 7.0 5.4 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region FAM60A PF15396.6 EFA76494.1 - 1 9.3 12.0 5.2 7.0 4.7 2.3 2 0 0 2 2 2 0 Protein Family FAM60A SR-25 PF10500.9 EFA76494.1 - 1.3 8.6 15.7 1.2 8.7 10.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Tim54 PF11711.8 EFA76494.1 - 2.8 6.6 13.5 1.4 7.7 0.4 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 EFA76494.1 - 4.4 6.4 8.2 4.9 6.3 5.1 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter CLN3 PF02487.17 EFA76494.1 - 5.5 5.9 10.8 7.7 5.4 0.5 2.2 2 0 0 2 2 2 0 CLN3 protein Band_3_cyto PF07565.13 EFA76494.1 - 7.5 6.3 13.6 18 5.0 0.2 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF2981 PF11200.8 EFA76494.1 - 8.4 6.0 14.5 0.81 9.4 8.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) UQ_con PF00179.26 EFA76498.1 - 2.4e-44 150.4 0.0 2.7e-44 150.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFA76498.1 - 0.012 15.9 0.2 0.014 15.6 0.2 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EFA76498.1 - 0.021 14.5 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UFC1 PF08694.11 EFA76498.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 EGF_2 PF07974.13 EFA76499.1 - 0.0032 17.8 13.2 0.008 16.5 13.2 1.7 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA76499.1 - 0.017 15.4 2.9 0.051 13.9 2.9 1.7 1 0 0 1 1 1 0 EB module CD99L2 PF12301.8 EFA76499.1 - 0.017 15.4 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 CD99 antigen like protein 2 LRR_4 PF12799.7 EFA76499.1 - 0.04 14.3 4.9 2.2 8.8 0.6 3.4 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LapA_dom PF06305.11 EFA76499.1 - 0.14 12.0 0.1 0.38 10.6 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EGF PF00008.27 EFA76499.1 - 0.19 12.1 10.4 0.53 10.6 10.4 1.7 1 0 0 1 1 1 0 EGF-like domain DUF4321 PF14209.6 EFA76499.1 - 5.7 6.9 6.7 1.3 9.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4321) CLU PF13236.6 EFA76500.1 - 6e-58 196.3 0.0 2.5e-57 194.2 0.0 2.1 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA76500.1 - 5.1e-07 29.9 0.0 5.1e-07 29.9 0.0 2.6 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 BAR PF03114.18 EFA76501.1 - 4.8e-17 62.4 13.2 5.3e-17 62.3 13.2 1.0 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EFA76501.1 - 1.3e-15 57.7 6.8 1.3e-15 57.7 6.8 1.3 1 1 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.13 EFA76501.1 - 1.5e-07 31.2 12.4 1.8e-07 31.0 12.4 1.0 1 0 0 1 1 1 1 Arfaptin-like domain BAR_2 PF10455.9 EFA76501.1 - 0.022 13.9 12.7 0.029 13.5 12.7 1.2 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Mt_ATP_synt PF15704.5 EFA76501.1 - 0.03 14.2 3.2 0.03 14.2 3.2 2.7 2 1 1 3 3 3 0 Mitochondrial ATP synthase subunit CK1gamma_C PF12605.8 EFA76501.1 - 0.11 13.7 0.2 1.5 10.0 0.0 2.2 2 0 0 2 2 2 0 Casein kinase 1 gamma C terminal KELK PF15796.5 EFA76501.1 - 0.24 11.9 14.6 1.2 9.6 1.1 3.4 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase MAD PF05557.13 EFA76501.1 - 0.32 9.3 16.3 0.018 13.4 8.9 1.9 2 0 0 2 2 2 0 Mitotic checkpoint protein Med30 PF11315.8 EFA76501.1 - 0.46 10.7 9.2 3.6 7.8 3.9 2.9 2 1 0 2 2 2 0 Mediator complex subunit 30 PerC PF06069.11 EFA76501.1 - 0.5 10.6 4.9 17 5.7 0.1 3.3 3 1 1 4 4 4 0 PerC transcriptional activator Tup_N PF08581.10 EFA76501.1 - 1.5 9.2 9.3 7.3 7.0 6.6 2.5 2 0 0 2 2 2 0 Tup N-terminal ERM PF00769.19 EFA76502.1 - 0.0023 17.8 3.3 0.0037 17.1 3.3 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Nnf1 PF03980.14 EFA76502.1 - 0.0039 17.5 2.0 0.061 13.7 0.0 2.2 1 1 0 2 2 2 1 Nnf1 KASH_CCD PF14662.6 EFA76502.1 - 0.006 16.4 4.6 0.0081 16.0 4.6 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH FapA PF03961.13 EFA76502.1 - 0.0075 14.9 1.9 0.0087 14.7 1.9 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A HALZ PF02183.18 EFA76502.1 - 0.043 14.1 4.9 0.73 10.1 1.0 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper LPP PF04728.13 EFA76502.1 - 0.043 14.2 2.7 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 Lipoprotein leucine-zipper bZIP_1 PF00170.21 EFA76502.1 - 0.079 13.1 0.6 0.079 13.1 0.6 2.4 1 1 1 2 2 2 0 bZIP transcription factor PRKG1_interact PF15898.5 EFA76502.1 - 0.26 12.2 8.8 4.9 8.1 0.1 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CHDCT2 PF08074.11 EFA76502.1 - 0.32 11.1 5.8 4.4 7.5 0.6 2.1 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain YabA PF06156.13 EFA76502.1 - 0.32 11.6 3.0 0.63 10.7 2.5 1.7 1 1 1 2 2 2 0 Initiation control protein YabA MCU PF04678.13 EFA76502.1 - 0.46 10.6 3.3 0.55 10.3 2.4 1.5 1 1 0 1 1 1 0 Mitochondrial calcium uniporter PspB PF06667.12 EFA76502.1 - 1 9.4 4.8 1.8 8.7 0.8 2.4 1 1 1 2 2 2 0 Phage shock protein B SRC-1 PF08832.10 EFA76502.1 - 1.8 9.7 5.6 7.4 7.7 5.6 2.0 1 1 0 1 1 1 0 Steroid receptor coactivator DivIC PF04977.15 EFA76502.1 - 4.6 7.1 8.8 4.3 7.2 0.4 2.3 1 1 1 2 2 2 0 Septum formation initiator MGC-24 PF05283.11 EFA76503.1 - 4.5 7.7 10.8 8.2 6.9 10.8 1.5 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin ANAPC4_WD40 PF12894.7 EFA76504.1 - 7.9e-20 71.0 0.1 2.9e-19 69.2 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2722 PF10846.8 EFA76504.1 - 0.001 18.2 2.0 0.001 18.2 2.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) RPA43_OB PF17875.1 EFA76504.1 - 1.5 9.4 5.4 14 6.3 2.3 2.6 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I E7 PF00527.18 EFA76504.1 - 2.2 8.6 10.8 47 4.3 8.2 2.8 2 0 0 2 2 2 0 E7 protein, Early protein DUF719 PF05334.13 EFA76504.1 - 4.8 7.3 9.8 10 6.3 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Roughex PF06020.11 EFA76504.1 - 5.6 6.0 15.3 0.79 8.8 3.4 2.3 2 0 0 2 2 2 0 Drosophila roughex protein Chorein_N PF12624.7 EFA76504.1 - 6.3 6.9 10.2 11 6.2 2.1 3.0 2 0 0 2 2 2 0 N-terminal region of Chorein or VPS13 CPSF100_C PF13299.6 EFA76504.1 - 7 6.8 9.8 9.6 6.4 3.0 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal U1snRNP70_N PF12220.8 EFA76504.1 - 7.2 7.3 10.2 17 6.1 0.6 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal TFIIA PF03153.13 EFA76504.1 - 8.8 6.2 24.9 34 4.3 24.9 1.8 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit adh_short PF00106.25 EFA76505.1 - 1.8e-11 43.8 0.3 1.8e-06 27.5 0.2 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76505.1 - 4.5e-06 26.4 0.1 0.0025 17.4 0.1 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Pyr_redox_3 PF13738.6 EFA76505.1 - 0.006 15.9 0.0 0.0067 15.7 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA76505.1 - 0.11 12.1 0.1 1.9 8.0 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glyco_hydro_9 PF00759.19 EFA76506.1 - 1.2e-107 360.9 5.2 4.9e-98 329.3 1.3 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 9 Glyco_hydro_127 PF07944.12 EFA76506.1 - 0.016 13.8 0.1 0.036 12.6 0.1 1.6 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Ccdc124 PF06244.12 EFA76507.1 - 1.6e-30 106.3 40.0 7.6e-27 94.4 40.0 2.8 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 L51_S25_CI-B8 PF05047.16 EFA76507.1 - 0.077 12.9 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain NuA4 PF09340.10 EFA76508.1 - 2.1e-22 78.8 0.1 2.1e-22 78.8 0.1 2.7 2 1 1 3 3 3 1 Histone acetyltransferase subunit NuA4 Shufflon_N PF04917.12 EFA76508.1 - 8.1e-05 22.2 0.5 9.9e-05 21.9 0.5 1.1 1 0 0 1 1 1 1 Bacterial shufflon protein, N-terminal constant region Golgin_A5 PF09787.9 EFA76508.1 - 0.00064 19.3 2.3 0.00064 19.3 2.3 1.3 1 1 0 1 1 1 1 Golgin subfamily A member 5 APG6_N PF17675.1 EFA76508.1 - 0.0051 17.3 1.2 0.0051 17.3 1.2 2.0 2 0 0 2 2 2 1 Apg6 coiled-coil region Osmo_CC PF08946.10 EFA76508.1 - 0.074 13.3 0.8 0.23 11.7 0.7 1.9 1 1 0 1 1 1 0 Osmosensory transporter coiled coil NAM-associated PF14303.6 EFA76508.1 - 0.22 12.2 8.9 0.62 10.8 8.9 1.7 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain GED PF02212.18 EFA76508.1 - 0.25 11.5 6.8 3.1 8.0 1.0 2.2 2 0 0 2 2 2 0 Dynamin GTPase effector domain DUF3450 PF11932.8 EFA76508.1 - 0.31 10.3 5.0 0.04 13.2 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SSP160 PF06933.11 EFA76508.1 - 0.73 8.0 11.2 0.043 12.0 6.3 1.4 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 BLOC1_2 PF10046.9 EFA76508.1 - 1.5 9.1 10.4 0.095 13.0 5.0 1.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Pex14_N PF04695.13 EFA76508.1 - 6.5 7.4 8.4 4 8.1 2.8 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0160 PF03690.13 EFA76510.1 - 1.1e-121 406.3 2.0 1.3e-121 406.2 2.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) M16C_assoc PF08367.11 EFA76511.1 - 1.8e-68 230.4 2.3 3.3e-68 229.5 2.3 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFA76511.1 - 2.7e-27 96.0 0.4 5.5e-19 68.9 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFA76511.1 - 2.7e-08 33.9 0.0 1e-07 32.0 0.0 2.0 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) AAA_23 PF13476.6 EFA76512.1 - 1.9 9.0 23.9 3.2 8.2 23.9 1.4 1 0 0 1 1 1 0 AAA domain HXXEE PF13787.6 EFA76512.1 - 2 9.2 14.8 0.063 14.1 2.3 3.7 4 0 0 4 4 4 0 Protein of unknown function with HXXEE motif zf-C3HC4_3 PF13920.6 EFA76513.1 - 0.017 15.0 5.2 1.5 8.7 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 EFA76513.1 - 0.022 14.5 0.1 0.022 14.5 0.1 2.3 2 0 0 2 2 2 0 SAP domain EF1G PF00647.19 EFA76514.1 - 3.3e-38 130.0 0.0 4.2e-38 129.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain Ribosomal_L22 PF00237.19 EFA76515.1 - 6.4e-38 129.1 1.2 8.6e-38 128.7 1.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e zf-C3HC4_3 PF13920.6 EFA76517.1 - 3.8e-08 33.1 12.6 5.1e-08 32.6 12.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA76517.1 - 3.6e-06 26.7 16.1 7.1e-06 25.8 16.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA76517.1 - 5.9e-05 22.9 10.8 9.7e-05 22.3 3.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFA76517.1 - 9.7e-05 22.1 16.7 0.0026 17.6 17.1 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFA76517.1 - 0.0001 22.5 18.4 0.0002 21.6 18.4 1.5 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA76517.1 - 0.00074 19.3 16.0 0.0014 18.4 16.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Cys_rich_KTR PF14205.6 EFA76517.1 - 0.0036 17.1 2.7 0.072 12.9 0.3 2.5 2 0 0 2 2 2 1 Cysteine-rich KTR zf-RING_4 PF14570.6 EFA76517.1 - 0.016 15.0 6.7 0.016 15.0 6.7 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF1053 PF06327.14 EFA76517.1 - 0.017 15.7 0.4 0.025 15.1 0.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) zf-RING_UBOX PF13445.6 EFA76517.1 - 0.041 13.9 15.7 0.24 11.4 10.2 2.4 2 0 0 2 2 2 0 RING-type zinc-finger FdhE PF04216.12 EFA76517.1 - 1.4 8.7 13.6 2.3 8.0 13.4 1.3 1 1 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-rbx1 PF12678.7 EFA76517.1 - 3.8 7.9 17.7 17 5.8 17.7 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain Oxidored_q6 PF01058.22 EFA76518.1 - 9.6e-22 77.2 0.1 1.2e-21 76.9 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Tmemb_14 PF03647.13 EFA76518.1 - 0.086 13.6 0.0 0.14 12.9 0.0 1.4 1 0 0 1 1 1 0 Transmembrane proteins 14C SnoaL_2 PF12680.7 EFA76519.1 - 9.8e-06 26.2 0.0 1.6e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EFA76519.1 - 0.0016 18.2 0.3 0.0041 16.9 0.3 1.6 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase ApoO PF09769.9 EFA76519.1 - 0.017 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein O DUF1453 PF07301.11 EFA76519.1 - 0.071 13.1 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1453) VPS13_C PF16909.5 EFA76520.1 - 3.5e-24 85.5 5.7 9.6e-23 80.9 1.6 3.5 2 1 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 EFA76520.1 - 7.3e-18 64.9 5.1 9.9e-16 57.9 0.0 3.2 2 1 1 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 Apt1 PF10351.9 EFA76520.1 - 1e-07 31.2 1.8 1e-07 31.2 1.8 1.8 2 0 0 2 2 2 1 Golgi-body localisation protein domain ATG_C PF09333.11 EFA76520.1 - 0.0039 17.5 0.0 0.0096 16.2 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain DUF4796 PF16044.5 EFA76520.1 - 0.05 13.2 0.3 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4796) VPS13 PF16908.5 EFA76521.1 - 1.2e-68 231.5 0.4 1.2e-68 231.5 0.4 3.2 3 1 1 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 EFA76521.1 - 3.8e-43 147.6 16.7 2.8e-28 99.0 2.1 4.2 4 0 0 4 4 4 3 Repeating coiled region of VPS13 Chorein_N PF12624.7 EFA76521.1 - 3e-39 133.7 1.1 3e-39 133.7 1.1 3.3 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 Ras PF00071.22 EFA76522.1 - 9.8e-35 119.5 0.1 1.3e-34 119.1 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA76522.1 - 1.7e-19 70.2 0.4 9.2e-19 67.8 0.4 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA76522.1 - 1.5e-09 37.5 0.4 4.5e-09 36.0 0.4 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA76522.1 - 2.5e-05 23.8 0.1 2.6e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA76522.1 - 9.9e-05 22.4 0.0 0.00016 21.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA76522.1 - 0.00051 19.5 0.2 0.00076 19.0 0.2 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFA76522.1 - 0.018 14.2 2.9 0.23 10.6 0.7 2.1 1 1 1 2 2 2 0 G-protein alpha subunit RsgA_GTPase PF03193.16 EFA76522.1 - 0.036 14.0 0.4 2.6 7.9 0.1 2.5 2 1 1 3 3 3 0 RsgA GTPase YdaS_antitoxin PF15943.5 EFA76522.1 - 0.04 13.8 0.0 1.9 8.4 0.0 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT PduV-EutP PF10662.9 EFA76522.1 - 0.11 12.2 0.3 0.22 11.3 0.3 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation EMC3_TMCO1 PF01956.16 EFA76523.1 - 1.2e-35 122.8 4.6 1.3e-35 122.6 4.6 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like CHD5 PF04420.14 EFA76523.1 - 0.014 15.2 3.4 0.077 12.9 3.4 1.9 1 1 0 1 1 1 0 CHD5-like protein DUF2721 PF11026.8 EFA76523.1 - 0.021 14.7 0.9 0.025 14.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) MapZ_EC1 PF18041.1 EFA76523.1 - 0.071 13.4 7.0 0.26 11.5 1.2 2.1 1 1 1 2 2 2 0 MapZ extracellular domain 1 DivIC PF04977.15 EFA76523.1 - 0.92 9.3 5.4 2.3 8.1 3.8 2.3 2 1 0 2 2 2 0 Septum formation initiator MIT PF04212.18 EFA76524.1 - 1e-46 156.9 16.4 5.6e-18 64.8 3.3 3.2 3 0 0 3 3 3 3 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 EFA76524.1 - 0.00054 19.8 2.3 0.96 9.6 0.1 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat Ferritin PF00210.24 EFA76524.1 - 0.018 15.0 0.7 0.045 13.7 0.7 1.6 1 0 0 1 1 1 0 Ferritin-like domain DUF2383 PF09537.10 EFA76524.1 - 0.018 15.4 0.2 0.89 9.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) TPR_1 PF00515.28 EFA76524.1 - 0.035 13.9 3.4 32 4.6 0.1 4.9 3 2 4 7 7 7 0 Tetratricopeptide repeat DUF5404 PF17397.2 EFA76524.1 - 0.071 13.3 3.7 4.3 7.5 0.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5404) TPR_2 PF07719.17 EFA76524.1 - 0.11 12.7 4.7 66 4.0 0.2 4.9 4 2 1 6 6 6 0 Tetratricopeptide repeat SMBP PF16785.5 EFA76524.1 - 0.11 12.7 0.5 4.3 7.6 0.1 2.7 3 0 0 3 3 3 0 Small metal-binding protein Sec7 PF01369.20 EFA76525.1 - 4.7e-58 195.9 5.8 4.7e-58 195.9 5.8 1.7 2 0 0 2 2 2 1 Sec7 domain PH PF00169.29 EFA76525.1 - 7.4e-20 71.4 1.2 3.5e-19 69.2 1.2 2.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA76525.1 - 9.2e-07 29.3 1.2 9.2e-07 29.3 1.2 2.9 3 0 0 3 3 3 1 Pleckstrin homology domain Spectrin_like PF18373.1 EFA76525.1 - 0.034 14.2 2.3 0.07 13.2 0.1 2.8 2 0 0 2 2 2 0 Spectrin like domain PH_9 PF15410.6 EFA76525.1 - 0.14 12.5 3.6 22 5.5 0.0 3.8 3 0 0 3 3 3 0 Pleckstrin homology domain DUF5381 PF17353.2 EFA76525.1 - 3 7.5 11.7 2.1 8.1 2.8 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5381) ENTH PF01417.20 EFA76526.1 - 2.5e-43 147.1 0.1 3.9e-43 146.5 0.1 1.3 1 0 0 1 1 1 1 ENTH domain VHS PF00790.19 EFA76526.1 - 0.051 13.4 0.1 0.087 12.7 0.1 1.2 1 0 0 1 1 1 0 VHS domain ANTH PF07651.16 EFA76526.1 - 0.099 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 ANTH domain RNA_pol_Rpb5_C PF01191.19 EFA76527.1 - 2.7e-32 110.4 0.5 2.7e-32 110.4 0.5 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EFA76527.1 - 4.6e-23 81.6 1.5 2.2e-22 79.4 0.2 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain FAS_meander PF17951.1 EFA76527.1 - 0.0054 16.6 0.6 0.083 12.7 0.1 2.6 1 1 2 3 3 3 1 Fatty acid synthase meander beta sheet domain Sof1 PF04158.14 EFA76527.1 - 0.062 13.6 0.2 0.062 13.6 0.2 1.9 2 0 0 2 2 2 0 Sof1-like domain Rap_GAP PF02145.15 EFA76528.1 - 4.7e-60 202.3 0.2 8.9e-60 201.4 0.2 1.5 1 0 0 1 1 1 1 Rap/ran-GAP CNH PF00780.22 EFA76528.1 - 5.8e-35 121.2 0.1 3.4e-26 92.5 0.0 2.3 2 0 0 2 2 2 2 CNH domain SR-25 PF10500.9 EFA76528.1 - 2.4 7.7 15.1 4.5 6.8 15.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Beta-lactamase PF00144.24 EFA76529.1 - 8.1e-44 150.2 0.0 1.4e-43 149.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_M15 PF01427.17 EFA76529.1 - 4.5e-27 95.1 0.1 9.3e-27 94.1 0.1 1.5 1 0 0 1 1 1 1 D-ala-D-ala dipeptidase Beta-lactamase2 PF13354.6 EFA76529.1 - 0.15 11.7 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase enzyme family VanY PF02557.17 EFA76529.1 - 0.25 11.1 0.7 0.61 9.9 0.7 1.7 1 1 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Beta-lactamase PF00144.24 EFA76530.1 - 3.2e-45 154.8 0.0 5.3e-45 154.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_M15 PF01427.17 EFA76530.1 - 2.3e-26 92.8 0.1 4.9e-26 91.7 0.1 1.5 1 0 0 1 1 1 1 D-ala-D-ala dipeptidase Pur_ac_phosph_N PF16656.5 EFA76531.1 - 2.9e-08 34.2 0.0 6.9e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EFA76531.1 - 9.8e-07 29.5 0.0 2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pex24p PF06398.11 EFA76531.1 - 0.004 16.2 0.7 0.0069 15.4 0.7 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF2207 PF09972.9 EFA76531.1 - 0.79 8.4 2.9 45 2.6 4.9 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Tubulin PF00091.25 EFA76532.1 - 1.8e-70 237.2 0.1 3.5e-70 236.2 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFA76532.1 - 5.2e-40 136.5 0.1 8.4e-40 135.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFA76532.1 - 2.8e-07 30.9 0.0 6.1e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFA76532.1 - 0.00093 18.9 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EFA76532.1 - 0.076 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Tubulin like STATa_Ig PF18214.1 EFA76533.1 - 9e-06 25.7 1.1 1.3e-05 25.2 0.2 1.8 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain Nucleoplasmin PF03066.15 EFA76534.1 - 0.041 14.4 1.2 0.048 14.2 1.2 1.2 1 0 0 1 1 1 0 Nucleoplasmin/nucleophosmin domain Porin_3 PF01459.22 EFA76535.1 - 5.3e-29 101.5 10.2 1.4e-21 77.1 5.3 2.0 1 1 1 2 2 2 2 Eukaryotic porin NST1 PF13945.6 EFA76535.1 - 0.28 11.3 6.5 0.47 10.5 6.5 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Acetyltransf_7 PF13508.7 EFA76536.1 - 5.5e-08 33.1 0.0 1.3e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA76536.1 - 1.4e-07 31.8 0.0 2.8e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA76536.1 - 2.5e-07 30.7 0.0 1.9e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA76536.1 - 7.3e-05 22.7 0.6 0.00023 21.1 0.0 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.7 EFA76536.1 - 0.051 13.6 0.2 0.18 11.9 0.2 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DHR-2 PF06920.13 EFA76537.1 - 1.4e-93 314.4 16.4 1.6e-92 310.9 16.4 2.2 1 1 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 EFA76538.1 - 1.7e-71 241.1 0.1 8.4e-71 238.9 0.1 2.1 1 1 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EFA76538.1 - 6e-43 146.9 1.1 5e-41 140.7 1.1 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EFA76538.1 - 3.5e-06 26.8 0.0 7.1e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA76538.1 - 1e-05 25.0 0.0 2.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Glyco_hydro_35 PF01301.19 EFA76539.1 - 1.2e-49 169.7 1.9 1.8e-49 169.1 1.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 GHD PF17834.1 EFA76539.1 - 0.0013 18.8 0.1 0.0068 16.4 0.0 2.1 2 0 0 2 2 2 1 Beta-sandwich domain in beta galactosidase Glyco_hydro_35 PF01301.19 EFA76540.1 - 6.2e-36 124.6 0.0 7.5e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EFA76540.1 - 5.8e-07 29.2 0.0 7.3e-07 28.9 0.0 1.0 1 0 0 1 1 1 1 Beta-galactosidase Cellulase PF00150.18 EFA76540.1 - 0.018 14.5 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) FMN_red PF03358.15 EFA76540.1 - 0.081 12.7 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 NADPH-dependent FMN reductase ORC5_C PF14630.6 EFA76541.1 - 2.2e-07 30.7 0.0 2.4e-07 30.6 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus DUF3923 PF13061.6 EFA76541.1 - 0.04 14.0 0.0 0.053 13.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3923) ORC5_C PF14630.6 EFA76542.1 - 1.7e-15 57.3 0.5 1.7e-15 57.3 0.5 2.7 3 0 0 3 3 3 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_22 PF13401.6 EFA76542.1 - 8.4e-06 26.1 1.9 0.00055 20.2 1.9 2.7 1 1 0 1 1 1 1 AAA domain UPF0542 PF15086.6 EFA76542.1 - 0.067 13.1 0.2 9.7 6.2 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 EMC3_TMCO1 PF01956.16 EFA76542.1 - 0.26 11.0 3.3 0.42 10.3 0.1 2.6 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like BST2 PF16716.5 EFA76542.1 - 1.6 9.3 12.1 2.1 9.0 4.8 2.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DDE_Tnp_4 PF13359.6 EFA76543.1 - 0.11 12.2 0.1 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 DDE superfamily endonuclease EST1 PF10374.9 EFA76543.1 - 0.28 11.8 2.3 0.43 11.2 1.2 1.8 2 0 0 2 2 2 0 Telomerase activating protein Est1 CP12 PF02672.15 EFA76543.1 - 4.3 8.2 6.6 0.58 11.0 0.6 2.5 3 1 0 3 3 3 0 CP12 domain SpoIIE PF07228.12 EFA76545.1 - 0.088 12.7 0.0 0.37 10.7 0.0 2.0 2 1 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) UQ_con PF00179.26 EFA76546.1 - 6e-39 132.9 0.1 9.7e-39 132.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme VWA_2 PF13519.6 EFA76546.1 - 7.5e-13 49.1 1.0 6.3e-12 46.1 0.0 2.8 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 EFA76546.1 - 1.5e-10 41.6 0.3 2.2e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain ubiquitin PF00240.23 EFA76546.1 - 0.00017 21.2 1.1 0.00039 20.1 1.1 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA76546.1 - 0.002 17.9 0.5 0.0048 16.7 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RWD PF05773.22 EFA76546.1 - 0.056 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EFA76546.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B fn3 PF00041.21 EFA76548.1 - 2e-11 44.1 14.2 0.0062 16.8 1.4 6.6 5 2 0 5 5 5 4 Fibronectin type III domain EGF_2 PF07974.13 EFA76548.1 - 1.3e-05 25.4 14.6 4.1e-05 23.9 14.6 1.9 1 0 0 1 1 1 1 EGF-like domain Tissue_fac PF01108.17 EFA76548.1 - 3.3e-05 23.7 3.0 0.1 12.5 0.1 4.9 4 1 0 4 4 4 2 Tissue factor Pur_ac_phosph_N PF16656.5 EFA76548.1 - 0.034 14.7 32.2 2.4 8.8 9.5 7.0 6 2 0 6 6 6 0 Purple acid Phosphatase, N-terminal domain EGF PF00008.27 EFA76548.1 - 0.052 13.9 7.9 0.15 12.4 7.9 1.9 1 0 0 1 1 1 0 EGF-like domain I-EGF_1 PF18372.1 EFA76548.1 - 0.072 13.2 8.4 0.2 11.8 8.4 1.8 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 EFA76548.1 - 2.6 8.2 8.0 0.6 10.2 2.8 2.6 2 0 0 2 2 2 0 Tenascin EGF domain Laminin_EGF PF00053.24 EFA76548.1 - 8.9 6.6 13.5 0.74 10.0 7.7 2.2 2 0 0 2 2 2 0 Laminin EGF domain Podoplanin PF05808.11 EFA76549.1 - 3.5e-05 24.0 0.0 9.8e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Podoplanin DUF4448 PF14610.6 EFA76549.1 - 0.026 14.3 0.1 0.22 11.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.6 EFA76549.1 - 0.043 14.7 0.3 0.13 13.2 0.3 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 EFA76549.1 - 0.069 12.9 4.1 0.17 11.7 4.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4690 PF15756.5 EFA76549.1 - 0.071 13.7 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 Small Novel Rich in Cartilage TNFR_16_TM PF18422.1 EFA76549.1 - 7.3 6.6 6.5 1.5 8.8 0.8 2.4 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Aldo_ket_red PF00248.21 EFA76550.1 - 7.3e-54 182.9 0.0 9e-54 182.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Orthopox_F7 PF05813.12 EFA76550.1 - 0.098 12.8 0.1 0.35 11.0 0.0 1.9 2 0 0 2 2 2 0 Orthopoxvirus F7 protein Prp18 PF02840.15 EFA76551.1 - 7.4e-62 207.6 0.1 7.4e-62 207.6 0.1 2.6 3 1 0 3 3 3 1 Prp18 domain PRP4 PF08799.11 EFA76551.1 - 3.7e-13 48.8 1.4 6.9e-13 47.9 1.4 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like NTF2 PF02136.20 EFA76552.1 - 3.4e-27 95.4 0.0 3.8e-27 95.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EFA76552.1 - 0.00019 21.8 0.0 0.00022 21.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 EFA76552.1 - 0.15 12.7 0.0 0.18 12.5 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain RNase_T PF00929.24 EFA76553.1 - 3.6e-20 73.1 0.0 7e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 EFA76553.1 - 1.4e-07 31.6 0.0 3.7e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like Glyoxalase PF00903.25 EFA76553.1 - 3.9e-07 30.3 0.0 2e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EFA76553.1 - 0.01 15.8 3.7 0.012 15.5 0.1 3.0 3 1 0 3 3 3 0 Glyoxalase-like domain RNase_H_2 PF13482.6 EFA76553.1 - 0.018 15.1 0.1 0.082 12.9 0.1 2.0 1 1 0 1 1 1 0 RNase_H superfamily Acetyltransf_9 PF13527.7 EFA76554.1 - 9.5e-05 22.5 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain LRR_4 PF12799.7 EFA76554.1 - 0.034 14.6 1.2 0.08 13.4 1.2 1.6 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) ETRAMP PF09716.10 EFA76555.1 - 0.0081 16.2 0.1 0.023 14.8 0.1 1.8 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Amnionless PF14828.6 EFA76555.1 - 0.0099 14.8 2.4 0.16 10.7 0.5 2.8 3 0 0 3 3 3 2 Amnionless G8 PF10162.9 EFA76555.1 - 0.22 11.6 5.6 0.31 11.1 0.1 3.4 2 1 0 2 2 2 0 G8 domain DUF3539 PF12058.8 EFA76556.1 - 0.057 13.6 0.1 0.069 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) DDOST_48kD PF03345.14 EFA76557.1 - 8.3e-107 357.6 0.1 1.3e-106 357.0 0.1 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF4350 PF14258.6 EFA76557.1 - 0.011 16.1 0.0 0.032 14.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) baeRF_family11 PF18855.1 EFA76557.1 - 0.042 14.1 0.0 0.61 10.4 0.0 2.5 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 DUF4611 PF15387.6 EFA76557.1 - 0.7 10.1 2.6 1.6 9.0 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Menin PF05053.13 EFA76557.1 - 0.81 8.0 2.6 1.3 7.3 2.6 1.2 1 0 0 1 1 1 0 Menin RNase_T PF00929.24 EFA76558.1 - 1.2e-22 81.3 0.0 1.6e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 Exonuclease NMT PF01233.19 EFA76559.1 - 5.7e-77 257.0 0.5 9.1e-77 256.4 0.5 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EFA76559.1 - 5.5e-70 235.1 0.0 8.9e-70 234.5 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 EFA76559.1 - 0.00021 21.4 0.0 0.11 12.6 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA76559.1 - 0.016 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_15 PF17013.5 EFA76559.1 - 0.14 11.6 1.1 0.66 9.4 0.7 2.2 2 1 0 2 2 2 0 Putative acetyl-transferase Flavokinase PF01687.17 EFA76560.1 - 4.8e-31 107.3 0.0 6.1e-31 107.0 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Toxin_7 PF05980.12 EFA76561.1 - 4.7 7.5 11.1 1.1 9.6 1.5 4.3 3 1 0 3 3 3 0 Toxin 7 Oxysterol_BP PF01237.18 EFA76562.1 - 3.7e-64 216.9 6.5 4.5e-60 203.5 0.5 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein KN17_SH3 PF18131.1 EFA76562.1 - 0.083 13.0 0.2 0.31 11.2 0.0 2.0 2 0 0 2 2 2 0 KN17 SH3-like C-terminal domain NAD_binding_2 PF03446.15 EFA76563.1 - 3.1e-53 180.2 0.6 4.5e-53 179.7 0.6 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFA76563.1 - 2.5e-33 114.9 0.0 4.9e-33 114.0 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EFA76563.1 - 1.7e-09 38.1 0.1 4.2e-09 36.9 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EFA76563.1 - 2.7e-09 36.6 0.0 4.8e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFA76563.1 - 3.8e-07 29.8 0.2 6.2e-07 29.1 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 EFA76563.1 - 1.3e-06 28.4 0.2 5.6e-06 26.4 0.2 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EFA76563.1 - 2e-06 27.5 0.1 7.2e-05 22.4 0.1 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EFA76563.1 - 0.00027 21.2 0.1 0.00047 20.4 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 EFA76563.1 - 0.0006 19.9 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase OCD_Mu_crystall PF02423.15 EFA76563.1 - 0.00092 18.2 0.1 0.0013 17.8 0.1 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family ApbA PF02558.16 EFA76563.1 - 0.0032 17.1 0.0 0.0058 16.3 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EFA76563.1 - 0.0077 16.6 0.1 0.013 15.9 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding adh_short PF00106.25 EFA76563.1 - 0.012 15.1 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DpaA_N PF16924.5 EFA76563.1 - 0.025 14.6 0.0 0.056 13.5 0.0 1.6 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain GFO_IDH_MocA PF01408.22 EFA76563.1 - 0.029 15.2 1.1 0.06 14.2 0.1 2.0 3 0 0 3 3 2 0 Oxidoreductase family, NAD-binding Rossmann fold KR PF08659.10 EFA76563.1 - 0.037 13.9 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 KR domain NAD_Gly3P_dh_N PF01210.23 EFA76563.1 - 0.052 13.5 0.1 0.15 12.0 0.1 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 EFA76563.1 - 0.058 13.3 0.6 0.098 12.5 0.0 1.6 2 0 0 2 2 2 0 Rossmann-like domain adh_short_C2 PF13561.6 EFA76563.1 - 0.063 12.8 0.3 0.13 11.8 0.1 1.5 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase CBM49 PF09478.10 EFA76565.1 - 3.9e-17 62.3 1.9 7.9e-17 61.3 1.9 1.5 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 zf-U1 PF06220.12 EFA76566.1 - 2.7e-05 23.8 8.0 4.9e-05 23.0 8.0 1.5 1 0 0 1 1 1 1 U1 zinc finger zf-CCCH PF00642.24 EFA76566.1 - 0.00027 20.8 1.5 0.00045 20.1 1.5 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Annexin PF00191.20 EFA76566.1 - 0.073 13.2 0.3 0.16 12.0 0.3 1.6 1 0 0 1 1 1 0 Annexin PH_8 PF15409.6 EFA76567.1 - 0.0043 17.3 0.5 0.016 15.5 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PBD PF00786.28 EFA76567.1 - 0.064 13.6 0.1 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 P21-Rho-binding domain GST_N PF02798.20 EFA76568.1 - 5.4e-09 36.3 0.1 1.2e-08 35.2 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA76568.1 - 3.9e-06 27.0 0.7 1.4e-05 25.2 0.1 2.2 2 2 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA76568.1 - 2.1e-05 24.9 0.2 0.00014 22.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA76568.1 - 0.00035 20.8 0.0 0.0012 19.1 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA76568.1 - 0.00057 20.1 0.1 0.0017 18.5 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ACP_PD PF04336.12 EFA76568.1 - 0.14 12.6 0.2 1.1 9.7 0.0 2.3 3 0 0 3 3 3 0 Acyl carrier protein phosphodiesterase Citrate_synt PF00285.21 EFA76569.1 - 2.3e-24 86.1 0.0 5.2e-19 68.5 0.0 2.7 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 EFA76569.1 - 3.1e-09 36.8 0.1 6.4e-09 35.8 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EFA76569.1 - 0.00017 21.4 0.1 0.0027 17.5 0.0 2.6 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding PF02629.19 EFA76569.1 - 0.00054 20.6 0.0 0.0012 19.5 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain NLPC_P60 PF00877.19 EFA76570.1 - 0.0082 16.2 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 NlpC/P60 family Skp1 PF01466.19 EFA76571.1 - 0.00043 20.3 0.0 0.00086 19.4 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain zf_C2HC_14 PF18574.1 EFA76571.1 - 0.028 14.2 0.6 0.063 13.1 0.6 1.6 1 0 0 1 1 1 0 C2HC Zing finger domain FYVE PF01363.21 EFA76571.1 - 0.072 13.2 0.5 0.072 13.2 0.5 2.3 2 0 0 2 2 2 0 FYVE zinc finger PI3Ka PF00613.20 EFA76572.1 - 1.1e-17 64.0 1.1 2.4e-16 59.7 1.1 2.6 1 1 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA76572.1 - 0.00068 19.5 3.5 0.55 10.0 0.1 2.9 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PriCT_1 PF08708.11 EFA76572.1 - 0.11 12.3 0.4 0.74 9.6 0.0 2.5 2 0 0 2 2 2 0 Primase C terminal 1 (PriCT-1) RNase_HII PF01351.18 EFA76572.1 - 1.5 8.6 7.2 2.5 7.9 0.6 3.2 2 1 1 3 3 3 0 Ribonuclease HII PI3Ka PF00613.20 EFA76573.1 - 3.1e-21 75.6 3.9 1.1e-19 70.6 2.6 3.0 2 1 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA76573.1 - 5.5e-19 69.0 1.5 2.1e-16 60.5 0.3 3.7 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FYVE PF01363.21 EFA76573.1 - 6.9e-16 58.1 6.7 6.9e-16 58.1 6.7 2.0 2 0 0 2 2 2 1 FYVE zinc finger Skp1 PF01466.19 EFA76573.1 - 0.026 14.6 0.1 0.36 11.0 0.0 2.6 2 0 0 2 2 2 0 Skp1 family, dimerisation domain FYVE_2 PF02318.16 EFA76573.1 - 0.066 13.4 6.6 0.32 11.2 6.5 2.2 1 1 0 1 1 1 0 FYVE-type zinc finger zf-RING_5 PF14634.6 EFA76573.1 - 4.9 7.2 14.6 31 4.6 0.3 3.2 2 1 1 3 3 3 0 zinc-RING finger domain IBR PF01485.21 EFA76573.1 - 9.3 6.6 12.7 0.041 14.1 2.5 2.4 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain Ank_2 PF12796.7 EFA76574.1 - 3.9e-11 43.4 0.6 8.1e-06 26.3 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76574.1 - 2e-10 41.0 0.1 0.00057 20.4 0.0 2.6 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76574.1 - 1.2e-06 28.7 0.2 0.14 12.5 0.0 3.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76574.1 - 2.2e-06 27.6 0.1 1.2 9.9 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFA76574.1 - 0.00021 21.6 0.4 3.8 8.1 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeat HIGH_NTase1_ass PF16581.5 EFA76574.1 - 0.032 14.2 0.0 5.4 6.9 0.0 2.1 1 1 1 2 2 2 0 Cytidyltransferase-related C-terminal region DUF1843 PF08898.10 EFA76574.1 - 0.057 13.9 0.0 8.5 7.0 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF1843) SCAB_CC PF16712.5 EFA76575.1 - 0.005 16.7 7.4 0.14 12.0 0.2 2.9 3 0 0 3 3 3 2 Coiled-coil regions of plant-specific actin-binding protein RRM_1 PF00076.22 EFA76575.1 - 0.013 15.3 0.2 0.58 10.0 0.0 3.5 4 0 0 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prefoldin PF02996.17 EFA76576.1 - 1e-23 83.5 4.0 1.5e-23 83.0 4.0 1.2 1 0 0 1 1 1 1 Prefoldin subunit Tropomyosin PF00261.20 EFA76576.1 - 0.015 14.7 5.6 0.037 13.4 0.6 2.1 2 0 0 2 2 2 0 Tropomyosin DUF3740 PF12548.8 EFA76576.1 - 0.41 11.1 4.4 4.8 7.6 1.0 2.3 2 0 0 2 2 2 0 Sulfatase protein DUF1664 PF07889.12 EFA76576.1 - 0.82 9.7 8.9 3.1 7.9 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) XkdW PF09636.10 EFA76576.1 - 0.83 9.8 5.9 0.095 12.8 1.2 1.8 2 0 0 2 2 2 0 XkdW protein Ost4 PF10215.9 EFA76577.1 - 8.6e-16 57.5 2.2 9.2e-16 57.4 2.2 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase MIP PF00230.20 EFA76578.1 - 1.1e-47 162.7 13.3 1.3e-47 162.4 13.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein Ank_5 PF13857.6 EFA76578.1 - 2.7e-11 43.4 0.2 1e-05 25.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA76578.1 - 3.6e-10 40.3 0.0 6.8e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76578.1 - 5.3e-10 39.6 0.0 3.8e-06 27.3 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76578.1 - 1.1e-09 37.7 0.0 0.00025 21.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EFA76578.1 - 2.4e-09 37.2 0.0 0.00094 19.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Arm PF00514.23 EFA76579.1 - 3.5e-27 93.6 45.3 0.00014 21.8 0.2 17.4 19 0 0 19 19 19 7 Armadillo/beta-catenin-like repeat WW PF00397.26 EFA76579.1 - 4.3e-20 71.5 1.6 1.7e-11 44.0 0.3 2.4 2 0 0 2 2 2 2 WW domain FYVE PF01363.21 EFA76579.1 - 1.1e-14 54.3 9.8 2.7e-14 53.0 9.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger HEAT_2 PF13646.6 EFA76579.1 - 1e-09 38.6 2.9 0.36 11.2 0.0 7.9 6 1 1 7 7 7 1 HEAT repeats V-ATPase_H_C PF11698.8 EFA76579.1 - 4.3e-06 26.8 13.1 0.013 15.6 0.0 7.4 6 1 1 7 7 7 1 V-ATPase subunit H Cnd1 PF12717.7 EFA76579.1 - 0.00045 20.3 23.0 0.036 14.1 0.1 6.9 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EFA76579.1 - 0.013 15.5 36.6 0.088 12.7 0.2 7.5 6 1 1 7 7 7 0 Domain of unknown function (DUF3361) HEAT PF02985.22 EFA76579.1 - 0.031 14.5 19.0 0.23 11.8 0.0 8.6 9 0 0 9 9 9 0 HEAT repeat Atx10homo_assoc PF09759.9 EFA76579.1 - 0.39 10.8 19.5 0.46 10.5 0.1 6.9 8 2 2 10 10 9 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 EFA76579.1 - 4.2 8.0 13.2 3.7 8.2 0.3 5.3 6 1 0 6 6 4 0 HEAT-like repeat Katanin_con80 PF13925.6 EFA76579.1 - 7.1 6.6 9.0 7.1 6.6 0.0 4.2 4 0 0 4 4 4 0 con80 domain of Katanin TFIIA PF03153.13 EFA76579.1 - 7.7 6.4 12.8 16 5.3 12.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit KH_8 PF17903.1 EFA76580.1 - 2.3e-28 98.1 1.0 6e-28 96.8 0.0 2.2 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 EFA76580.1 - 0.035 13.9 0.4 0.22 11.4 0.0 2.5 2 1 1 3 3 3 0 KH domain AAA_23 PF13476.6 EFA76580.1 - 0.83 10.1 14.4 0.11 12.9 9.6 1.9 2 0 0 2 2 2 0 AAA domain Presenilin PF01080.17 EFA76580.1 - 9.1 4.9 7.5 18 4.0 7.5 1.5 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 EFA76580.1 - 9.9 4.9 9.5 15 4.2 9.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Pyr_redox_2 PF07992.14 EFA76581.1 - 3.2e-48 164.5 0.2 4.7e-48 163.9 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA76581.1 - 7.2e-21 74.7 0.8 8.8e-20 71.1 0.7 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA76581.1 - 8.4e-17 61.5 0.3 3e-15 56.6 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFA76581.1 - 0.003 16.7 1.2 1.2 8.1 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.6 EFA76581.1 - 0.0066 15.6 0.1 1.8 7.6 0.0 3.1 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 EFA76581.1 - 0.011 14.8 2.0 1.9 7.5 0.0 3.6 3 1 1 4 4 4 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EFA76581.1 - 0.018 15.5 0.2 0.12 12.8 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 EFA76581.1 - 0.028 13.2 0.0 4.3 5.9 0.1 2.6 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EFA76581.1 - 0.088 12.0 0.0 0.26 10.5 0.0 1.8 1 0 0 1 1 1 0 Thi4 family 2_5_RNA_ligase2 PF13563.6 EFA76582.1 - 2.6e-31 108.6 0.0 3e-31 108.4 0.0 1.0 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EFA76582.1 - 3.3e-07 30.4 0.0 0.0018 18.4 0.0 2.2 2 0 0 2 2 2 2 LigT like Phosphoesterase RRM_1 PF00076.22 EFA76583.1 - 1.1e-19 70.0 0.3 1.7e-19 69.4 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA76583.1 - 0.0077 15.8 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA76583.1 - 0.018 15.2 0.0 0.039 14.1 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif RRM_Rrp7 PF17799.1 EFA76583.1 - 0.022 14.5 0.1 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain HhH-GPD PF00730.25 EFA76584.1 - 9.8e-21 74.2 0.0 1.7e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EFA76584.1 - 0.006 16.4 0.0 0.021 14.7 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif DUF2664 PF10867.8 EFA76584.1 - 0.012 16.0 0.4 0.045 14.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2664) EndIII_4Fe-2S PF10576.9 EFA76584.1 - 1.8 9.0 6.3 3.5 8.1 6.3 1.5 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III WD40 PF00400.32 EFA76585.1 - 8.8e-38 127.6 23.3 1.4e-05 25.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76585.1 - 2.5e-12 46.9 0.0 0.078 13.3 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA76585.1 - 0.00022 20.7 0.0 0.0008 18.8 0.0 2.0 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 EFA76585.1 - 0.0031 16.2 0.3 0.57 8.8 0.1 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 CRF PF00473.17 EFA76585.1 - 0.19 11.8 1.9 0.35 11.0 1.9 1.3 1 0 0 1 1 1 0 Corticotropin-releasing factor family EMP70 PF02990.16 EFA76586.1 - 6e-150 500.3 12.2 8.1e-150 499.9 12.2 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF3792 PF12670.7 EFA76586.1 - 0.0051 17.0 16.0 0.0051 17.0 16.0 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF3792) CBM_11 PF03425.13 EFA76586.1 - 0.095 12.6 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Sod_Fe_C PF02777.18 EFA76587.1 - 9.2e-29 99.6 0.5 1.5e-28 99.0 0.5 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFA76587.1 - 5.3e-11 42.8 0.3 1.2e-10 41.7 0.3 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain MFS_1 PF07690.16 EFA76588.1 - 4.4e-27 94.9 23.6 4.4e-27 94.9 23.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA76588.1 - 0.0022 16.9 27.8 0.0043 16.0 27.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1676 PF07898.13 EFA76588.1 - 0.35 10.9 3.1 2.9 7.9 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1676) DUF5316 PF17247.2 EFA76588.1 - 0.9 9.6 5.6 0.26 11.3 0.4 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5316) DUF4615 PF15393.6 EFA76589.1 - 4.4e-08 33.8 11.7 4.4e-08 33.8 11.7 2.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4615) Inos-1-P_synth PF01658.17 EFA76589.1 - 0.098 12.9 2.7 0.23 11.7 2.7 1.8 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase UQ_con PF00179.26 EFA76590.1 - 3.3e-47 159.7 1.5 9.5e-44 148.4 1.5 2.0 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme TPR_1 PF00515.28 EFA76591.1 - 3.3e-22 77.3 3.4 5.5e-10 38.6 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76591.1 - 1.7e-19 68.3 1.5 4.9e-08 32.5 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76591.1 - 2.4e-18 64.7 1.0 4.7e-08 32.6 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76591.1 - 2.4e-16 59.1 9.1 1.2e-05 24.9 0.2 3.4 1 1 2 3 3 3 3 TPR repeat SGTA_dimer PF16546.5 EFA76591.1 - 6.3e-14 51.5 1.1 1.4e-13 50.4 1.1 1.6 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_17 PF13431.6 EFA76591.1 - 2.5e-13 49.4 3.7 5e-05 23.4 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76591.1 - 6.5e-09 36.3 0.0 2.1e-07 31.4 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA76591.1 - 2e-07 31.2 0.0 0.0018 19.0 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA76591.1 - 2.1e-07 31.1 0.5 0.0056 17.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76591.1 - 1.7e-06 27.6 0.4 0.052 13.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76591.1 - 2.2e-06 28.1 0.5 0.00033 21.1 0.1 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76591.1 - 0.00014 22.1 0.2 0.0016 18.7 0.1 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 EFA76591.1 - 0.00055 19.9 2.3 1.8 8.7 0.1 3.3 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 EFA76591.1 - 0.001 19.1 0.6 0.051 13.6 0.3 3.0 2 1 0 2 2 2 1 Domain of Unknown Function (DUF3856) ANAPC3 PF12895.7 EFA76591.1 - 0.0013 19.0 0.5 0.0021 18.3 0.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 STI1 PF17830.1 EFA76591.1 - 0.0059 16.5 7.5 0.015 15.2 7.5 1.7 1 0 0 1 1 1 1 STI1 domain TPR_9 PF13371.6 EFA76591.1 - 0.008 16.3 0.0 0.16 12.2 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF627 PF04781.12 EFA76591.1 - 0.015 15.3 0.8 0.17 11.9 0.1 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF627) BTB_2 PF02214.22 EFA76591.1 - 0.04 14.3 0.5 5 7.6 0.1 3.3 3 1 0 3 3 3 0 BTB/POZ domain RNase_3_N PF18497.1 EFA76591.1 - 0.044 14.0 0.9 0.58 10.4 0.2 2.6 1 1 0 2 2 2 0 Ribonuclease III N-terminal domain TPR_10 PF13374.6 EFA76591.1 - 0.07 13.0 0.7 4.3 7.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 EFA76591.1 - 0.084 11.8 1.5 0.51 9.2 0.3 2.2 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 BTAD PF03704.17 EFA76591.1 - 0.088 13.2 0.0 0.19 12.2 0.0 1.6 1 1 0 1 1 1 0 Bacterial transcriptional activator domain TPR_3 PF07720.12 EFA76591.1 - 0.11 12.5 1.0 2.9 8.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FAT PF02259.23 EFA76591.1 - 0.11 11.7 1.2 0.73 9.0 1.1 2.4 1 1 1 2 2 2 0 FAT domain TPR_15 PF13429.6 EFA76591.1 - 0.13 11.4 0.1 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TOM20_plant PF06552.12 EFA76591.1 - 0.17 11.6 3.8 1.9 8.2 0.2 3.2 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_14 PF13428.6 EFA76592.1 - 5.7e-09 36.1 13.3 0.2 12.6 0.0 8.2 7 2 2 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76592.1 - 3.4e-05 24.4 1.6 0.17 12.5 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76592.1 - 9.7e-05 22.8 15.3 0.55 10.8 0.0 7.0 6 1 2 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA76592.1 - 0.0013 19.0 2.3 0.045 14.1 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76592.1 - 0.028 14.5 16.3 2.7 8.3 0.0 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76592.1 - 0.036 14.3 11.2 36 4.9 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat CBS PF00571.28 EFA76593.1 - 9.1e-18 64.5 5.6 5.7e-07 29.9 0.0 4.9 3 1 1 4 4 4 4 CBS domain GRIM-19 PF06212.12 EFA76595.1 - 1.7e-15 57.1 0.0 3.1e-15 56.3 0.0 1.4 1 1 1 2 2 2 1 GRIM-19 protein PAP_assoc PF03828.19 EFA76596.1 - 4.4e-14 52.4 0.1 6e-13 48.8 0.1 2.9 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFA76596.1 - 6e-07 29.7 0.0 2.2e-06 27.9 0.0 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFA76596.1 - 0.0048 17.0 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase YcgR PF07317.12 EFA76596.1 - 0.034 14.0 0.0 0.29 11.0 0.0 2.5 2 0 0 2 2 2 0 Flagellar regulator YcgR FAD_binding_2 PF00890.24 EFA76597.1 - 5.1e-75 253.1 0.0 5.9e-75 252.9 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFA76597.1 - 3.8e-10 39.7 0.1 1.8e-09 37.5 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 EFA76597.1 - 9e-07 28.8 0.2 8.5e-06 25.6 0.2 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFA76597.1 - 3.1e-06 26.1 0.8 5.2e-06 25.4 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EFA76597.1 - 3.8e-06 26.3 0.3 2.5e-05 23.6 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFA76597.1 - 6.3e-05 22.3 0.2 0.00032 20.0 0.1 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EFA76597.1 - 0.00014 22.0 0.4 0.00047 20.3 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GDI PF00996.18 EFA76597.1 - 0.0061 15.1 0.1 0.074 11.6 0.1 2.0 2 0 0 2 2 2 1 GDP dissociation inhibitor GIDA PF01134.22 EFA76597.1 - 0.0062 15.7 0.5 0.012 14.7 0.5 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFA76597.1 - 0.035 13.4 0.1 0.049 12.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EFA76597.1 - 0.037 13.3 0.3 0.078 12.2 0.2 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Integrase_H2C2 PF17921.1 EFA76600.1 - 1.6e-17 63.4 0.2 3.5e-17 62.2 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 EFA76600.1 - 1e-12 48.1 0.1 3e-12 46.5 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EFA76600.1 - 3.1e-12 46.7 0.0 8e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 EFA76600.1 - 0.00013 21.9 0.2 0.00035 20.6 0.2 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA76600.1 - 0.00021 21.5 0.1 0.00069 19.9 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 EFA76600.1 - 0.0037 17.4 2.4 0.0038 17.4 0.3 2.2 2 0 0 2 2 2 1 H2C2 zinc finger CO_deh_flav_C PF03450.17 EFA76601.1 - 0.00037 20.6 0.1 0.0011 19.1 0.1 1.7 1 1 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain DUF4820 PF16091.5 EFA76602.1 - 8.2 5.7 12.0 1.2 8.4 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Ribosomal_S25 PF03297.15 EFA76603.1 - 4.8e-21 74.8 0.0 5.2e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 S25 ribosomal protein NSP11 PF06471.12 EFA76603.1 - 0.068 11.6 0.0 0.068 11.6 0.0 1.0 1 0 0 1 1 1 0 NSP11 CCG PF02754.16 EFA76603.1 - 0.15 12.3 0.0 0.19 12.0 0.0 1.1 1 0 0 1 1 1 0 Cysteine-rich domain Mito_carr PF00153.27 EFA76605.1 - 1.8e-07 31.0 0.1 0.0064 16.4 0.1 2.5 1 1 1 2 2 2 2 Mitochondrial carrier protein PC4 PF02229.16 EFA76606.1 - 2.6e-10 39.8 0.2 4.7e-10 38.9 0.2 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) YL1 PF05764.13 EFA76606.1 - 0.024 14.7 23.4 0.034 14.3 23.4 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF2651 PF10852.8 EFA76606.1 - 0.052 14.2 0.3 0.052 14.2 0.3 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2651) Apt1 PF10351.9 EFA76606.1 - 0.095 11.5 6.2 0.12 11.2 6.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SLC12 PF03522.15 EFA76606.1 - 0.19 10.7 5.7 0.23 10.4 5.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DHHC PF01529.20 EFA76606.1 - 0.31 11.1 6.7 4.7 7.3 0.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Presenilin PF01080.17 EFA76606.1 - 0.35 9.6 10.8 0.045 12.5 4.7 2.1 2 0 0 2 2 2 0 Presenilin Ost5 PF05251.12 EFA76606.1 - 0.5 10.7 0.1 0.5 10.7 0.1 3.3 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 NST1 PF13945.6 EFA76606.1 - 2.1 8.4 15.8 3 7.9 15.8 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF2569 PF10754.9 EFA76606.1 - 2.5 8.6 8.8 5.8 7.4 8.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) CDC45 PF02724.14 EFA76606.1 - 2.6 6.3 16.9 3.7 5.7 16.9 1.2 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 EFA76606.1 - 3.1 6.6 10.3 4.3 6.2 10.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2052 PF09747.9 EFA76606.1 - 3.2 7.8 13.8 4.3 7.4 13.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Sporozoite_P67 PF05642.11 EFA76606.1 - 4.7 5.2 15.1 6.4 4.7 15.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3807 PF12720.7 EFA76606.1 - 5 7.4 18.9 7.3 6.8 18.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) MatC_N PF07158.11 EFA76606.1 - 9.2 6.3 7.6 1.5 8.9 3.7 1.6 2 0 0 2 2 2 0 Dicarboxylate carrier protein MatC N-terminus TLD PF07534.16 EFA76607.1 - 2e-33 115.5 1.4 3.9e-33 114.6 1.4 1.5 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 EFA76607.1 - 0.00036 21.5 1.1 0.00074 20.5 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function MENTAL PF10457.9 EFA76607.1 - 0.39 10.5 0.0 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Cholesterol-capturing domain eIF-5a PF01287.20 EFA76608.1 - 1.2e-24 86.2 0.0 2e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EFA76608.1 - 0.0011 19.0 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Glyco_transf_20 PF00982.21 EFA76609.1 - 8.7e-155 516.0 0.0 1.4e-154 515.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFA76609.1 - 3e-48 164.0 0.0 5.8e-48 163.0 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EFA76609.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain zf-C3HC4_3 PF13920.6 EFA76610.1 - 2.8e-11 43.1 5.4 4.9e-11 42.3 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA76610.1 - 5.9e-11 42.5 10.3 1.1e-10 41.7 10.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA76610.1 - 1.1e-09 37.9 8.8 2.5e-09 36.8 8.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA76610.1 - 1.7e-09 37.4 9.2 3.3e-09 36.4 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA76610.1 - 5.8e-09 35.8 6.8 1.2e-08 34.8 6.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFA76610.1 - 3.5e-07 30.0 13.3 8.3e-06 25.6 11.0 2.7 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFA76610.1 - 3.8e-07 30.0 8.5 2e-06 27.7 8.9 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFA76610.1 - 5.8e-07 29.7 11.3 2.2e-06 27.8 10.1 2.3 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFA76610.1 - 0.0003 20.9 7.7 0.0009 19.3 7.7 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING TerY_C PF15616.6 EFA76610.1 - 0.00076 19.6 0.7 0.0018 18.4 0.7 1.7 1 0 0 1 1 1 1 TerY-C metal binding domain zf-RING_4 PF14570.6 EFA76610.1 - 0.001 18.8 8.7 0.004 16.9 8.8 1.9 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EFA76610.1 - 0.003 17.6 2.8 0.0067 16.5 2.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger VID27_N PF17748.1 EFA76610.1 - 0.02 14.7 2.5 0.7 9.7 0.1 2.9 3 0 0 3 3 3 0 VID27 N-terminal region FdhE PF04216.12 EFA76610.1 - 0.024 14.6 1.8 0.047 13.6 1.8 1.4 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-RING_11 PF17123.5 EFA76610.1 - 0.11 12.2 7.2 0.35 10.7 7.2 1.9 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_10 PF16685.5 EFA76610.1 - 0.26 11.5 2.4 0.73 10.0 2.4 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EFA76610.1 - 0.3 11.0 5.1 0.84 9.6 5.1 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein SusD-like_3 PF14322.6 EFA76610.1 - 0.34 11.2 9.4 0.15 12.3 7.0 1.6 2 0 0 2 2 2 0 Starch-binding associating with outer membrane IBR PF01485.21 EFA76610.1 - 0.43 10.8 6.3 1.4 9.2 6.3 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-P11 PF03854.14 EFA76610.1 - 0.93 9.2 6.2 2.3 7.9 6.2 1.7 1 1 0 1 1 1 0 P-11 zinc finger Zn-C2H2_12 PF18112.1 EFA76610.1 - 2.1 8.9 4.2 19 5.8 0.3 2.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FH2 PF02181.23 EFA76611.1 - 4.1e-85 286.1 10.0 1.5e-84 284.3 10.0 2.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFA76611.1 - 7.1e-10 38.8 5.5 2.4e-09 37.1 5.5 2.0 1 0 0 1 1 1 1 Diaphanous FH3 Domain FHA PF00498.26 EFA76611.1 - 2.2e-09 37.6 0.1 1.2e-08 35.2 0.1 2.5 1 1 0 1 1 1 1 FHA domain Ank_2 PF12796.7 EFA76612.1 - 2e-28 98.8 17.9 8.9e-10 39.0 0.1 3.5 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA76612.1 - 2.7e-18 65.8 9.5 0.00094 19.4 0.0 6.4 1 1 6 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA76612.1 - 6.1e-17 61.8 12.4 3.2e-05 24.4 0.0 6.1 3 1 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76612.1 - 3.7e-12 45.3 8.1 4.9 8.0 0.0 8.0 5 1 3 8 8 8 4 Ankyrin repeat Ank PF00023.30 EFA76612.1 - 0.0018 18.6 7.7 38 4.9 0.4 6.4 3 1 3 6 6 6 0 Ankyrin repeat DUF3645 PF12359.8 EFA76614.1 - 1.6e-12 46.5 0.1 3e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Abhydrolase_1 PF00561.20 EFA76615.1 - 3.3e-17 63.0 0.0 2.5e-16 60.1 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA76615.1 - 1.7e-11 45.2 0.0 2e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA76615.1 - 5.1e-09 35.7 0.0 6.7e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EFA76615.1 - 2e-08 34.3 0.2 7.6e-07 29.1 0.2 2.3 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 EFA76615.1 - 8.3e-06 25.5 0.1 1.4e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Esterase PF00756.20 EFA76615.1 - 0.00028 20.6 0.0 0.00041 20.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 EFA76615.1 - 0.00044 20.4 0.0 0.00059 20.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Say1_Mug180 PF10340.9 EFA76615.1 - 0.0017 17.3 0.1 0.0033 16.4 0.1 1.5 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase PF07224.11 EFA76615.1 - 0.0044 16.1 0.0 0.0053 15.8 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase PAF-AH_p_II PF03403.13 EFA76615.1 - 0.016 13.7 0.0 0.022 13.3 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II DUF915 PF06028.11 EFA76615.1 - 0.02 14.3 0.1 0.033 13.5 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 EFA76615.1 - 0.021 14.7 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Ndr PF03096.14 EFA76615.1 - 0.027 13.2 0.0 0.037 12.7 0.0 1.2 1 0 0 1 1 1 0 Ndr family DLH PF01738.18 EFA76615.1 - 0.093 12.3 0.0 3.1 7.3 0.0 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family DUF900 PF05990.12 EFA76615.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Nup96 PF12110.8 EFA76616.1 - 6.5e-68 229.0 0.1 1.1e-67 228.2 0.1 1.4 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EFA76616.1 - 6.7e-45 152.8 0.0 1.4e-44 151.8 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EFA76616.1 - 1.9e-05 25.4 67.3 7.2e-05 23.6 28.7 10.9 3 3 6 9 9 9 4 Nucleoporin FG repeat region Macoilin PF09726.9 EFA76616.1 - 2.3 6.7 11.2 7.3 5.0 11.2 1.8 1 0 0 1 1 1 0 Macoilin family GP3 PF03076.14 EFA76617.1 - 0.073 13.1 1.0 0.081 13.0 1.0 1.0 1 0 0 1 1 1 0 Equine arteritis virus GP3 DEC-1_N PF04625.13 EFA76618.1 - 4.6 6.1 6.3 6.8 5.6 6.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Glyco_hydro_38N PF01074.22 EFA76619.1 - 6e-67 226.0 0.5 9.7e-67 225.3 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 EFA76619.1 - 1.4e-18 66.8 0.0 3e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EFA76619.1 - 2.1e-06 27.8 0.1 5.1e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Phage_head_chap PF11113.8 EFA76619.1 - 0.004 17.2 0.1 11 6.2 0.0 3.4 3 0 0 3 3 3 2 Head assembly gene product CARDB PF07705.11 EFA76619.1 - 0.04 14.2 1.2 0.71 10.2 0.1 3.1 2 0 0 2 2 2 0 CARDB adh_short PF00106.25 EFA76620.1 - 3e-43 147.6 0.1 3.8e-43 147.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76620.1 - 1.5e-32 113.1 0.1 1.8e-32 112.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76620.1 - 1.5e-09 38.0 0.1 2.3e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 KR domain DEAD PF00270.29 EFA76621.1 - 7.8e-36 123.5 0.6 1.6e-35 122.5 0.6 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA76621.1 - 2.9e-32 111.3 0.0 4.1e-30 104.4 0.0 3.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA76621.1 - 4.1e-06 26.9 3.8 3.6e-05 23.8 0.1 3.3 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 EFA76621.1 - 0.0019 17.8 0.2 0.027 14.0 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Flavi_DEAD PF07652.14 EFA76621.1 - 0.021 14.8 0.3 17 5.4 0.0 3.4 4 0 0 4 4 4 0 Flavivirus DEAD domain RecQ5 PF06959.11 EFA76621.1 - 0.17 11.8 6.9 0.32 11.0 6.9 1.4 1 0 0 1 1 1 0 RecQ helicase protein-like 5 (RecQ5) EBP50_C PF09007.11 EFA76621.1 - 0.23 12.4 0.2 0.23 12.4 0.2 3.0 2 1 1 3 3 3 0 EBP50, C-terminal Macoilin PF09726.9 EFA76621.1 - 1.4 7.4 14.3 2.2 6.7 14.3 1.3 1 0 0 1 1 1 0 Macoilin family DUF1993 PF09351.10 EFA76622.1 - 0.096 12.8 4.7 1.8 8.7 0.9 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) POR_N PF01855.19 EFA76622.1 - 0.86 9.3 3.5 0.68 9.6 0.1 2.2 2 1 0 2 2 2 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg AcylCoA_dehyd_C PF12186.8 EFA76622.1 - 1.4 9.1 8.3 0.68 10.1 1.5 2.6 2 1 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal PI_PP_I PF18363.1 EFA76622.1 - 2.4 8.4 8.3 2.7 8.2 1.6 3.1 1 1 2 3 3 3 0 Phosphoinositide phosphatase insertion domain CENP-H PF05837.12 EFA76622.1 - 2.9 8.3 18.0 0.57 10.6 8.0 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Lectin_N PF03954.14 EFA76622.1 - 3.4 7.4 8.5 4.8 6.9 1.4 2.5 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain FOXP-CC PF16159.5 EFA76622.1 - 7.4 7.3 6.5 7.8 7.2 2.2 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain SKA2 PF16740.5 EFA76622.1 - 9 6.1 17.8 0.062 13.1 3.6 3.1 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 YlqD PF11068.8 EFA76622.1 - 9.9 6.5 22.9 0.9 9.9 4.7 2.5 1 1 1 2 2 2 0 YlqD protein Ank_2 PF12796.7 EFA76623.1 - 5.1e-16 59.0 3.5 4.8e-07 30.3 0.2 4.8 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76623.1 - 5.6e-14 52.3 2.1 0.015 15.9 0.2 6.6 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76623.1 - 4.8e-09 35.7 1.1 2.3 9.0 0.0 7.6 8 0 0 8 8 8 1 Ankyrin repeat Ank_5 PF13857.6 EFA76623.1 - 3.2e-08 33.7 1.8 0.065 13.6 0.0 5.6 3 1 2 6 6 6 4 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA76623.1 - 0.00016 21.6 3.0 0.89 9.6 0.0 4.5 1 1 3 4 4 4 2 Domain of unknown function (DUF3447) Dimer_Tnp_hAT PF05699.14 EFA76625.1 - 9.5e-14 51.0 0.1 4.4e-13 48.8 0.2 2.0 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Calycin_like PF13944.6 EFA76625.1 - 0.022 15.1 0.6 0.075 13.4 0.3 1.9 2 0 0 2 2 2 0 Calycin-like beta-barrel domain DUF272 PF03312.15 EFA76625.1 - 0.039 14.2 0.2 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF272) TPR_17 PF13431.6 EFA76626.1 - 1.8e-66 215.8 8.4 1.6e-10 40.6 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76626.1 - 9.9e-07 28.4 15.4 2.1 8.1 0.2 6.4 7 0 0 7 7 7 4 TPR repeat Anth_Ig PF05587.13 EFA76626.1 - 1.9e-05 24.9 2.0 9.1 6.7 0.0 5.8 6 0 0 6 6 6 1 Anthrax receptor extracellular domain DUF1153 PF06627.11 EFA76626.1 - 6.5e-05 23.0 0.1 6.8 6.9 0.0 5.4 7 0 0 7 7 6 1 Protein of unknown function (DUF1153) Lyx_isomer PF07385.12 EFA76626.1 - 0.0022 17.3 0.0 6.4 6.0 0.0 4.6 2 2 2 5 5 5 1 D-lyxose isomerase YjzC PF14168.6 EFA76626.1 - 0.0033 17.7 0.0 16 6.0 0.0 4.1 4 0 0 4 4 4 0 YjzC-like protein Str_synth PF03088.16 EFA76626.1 - 0.0038 17.3 0.0 6.3 7.0 0.0 4.2 4 0 0 4 4 4 1 Strictosidine synthase NleF_casp_inhib PF16809.5 EFA76626.1 - 0.0056 16.6 0.5 49 3.8 0.0 4.6 4 1 1 5 5 5 0 NleF caspase inhibitor CLIP PF12032.8 EFA76626.1 - 0.006 16.8 9.1 12 6.2 0.0 6.6 6 1 0 6 6 6 0 Regulatory CLIP domain of proteinases WW_FCH_linker PF16623.5 EFA76626.1 - 0.0092 16.7 0.8 23 5.8 0.1 4.7 4 1 1 5 5 5 0 Unstructured linker region between on GAS7 protein Glyco_hydro_61 PF03443.14 EFA76626.1 - 0.013 15.4 0.6 4.3 7.2 0.1 3.5 3 1 0 4 4 4 0 Glycosyl hydrolase family 61 P22_CoatProtein PF11651.8 EFA76626.1 - 0.039 12.5 0.0 0.24 10.0 0.0 2.2 2 0 0 2 2 2 0 P22 coat protein - gene protein 5 DUF1344 PF07076.11 EFA76626.1 - 0.06 13.3 0.5 9.3 6.3 0.0 4.3 6 0 0 6 6 6 0 Protein of unknown function (DUF1344) TMEM131_like PF12371.8 EFA76626.1 - 0.11 12.8 0.0 1.6 9.0 0.0 2.9 3 1 1 4 4 3 0 Transmembrane protein 131-like Epiglycanin_TR PF05647.11 EFA76626.1 - 3.2 7.7 8.5 20 5.2 0.2 4.2 4 0 0 4 4 4 0 Tandem-repeating region of mucin, epiglycanin-like TPR_17 PF13431.6 EFA76627.1 - 7.4e-132 420.7 20.7 5.3e-11 42.1 0.0 12.1 12 0 0 12 12 12 12 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76627.1 - 8.6e-18 63.7 36.9 0.78 9.5 0.1 12.0 12 0 0 12 12 12 10 TPR repeat NleF_casp_inhib PF16809.5 EFA76627.1 - 2.3e-07 30.8 6.2 77 3.2 0.0 9.4 6 3 4 11 11 11 0 NleF caspase inhibitor Lyx_isomer PF07385.12 EFA76627.1 - 5.5e-07 29.1 9.2 27 3.9 0.0 9.5 1 1 8 11 11 11 0 D-lyxose isomerase Anth_Ig PF05587.13 EFA76627.1 - 6.2e-07 29.7 11.5 1.3e+02 2.9 0.0 9.7 10 0 0 10 10 10 0 Anthrax receptor extracellular domain SFTA2 PF15210.6 EFA76627.1 - 0.00044 20.1 22.2 12 5.9 0.1 10.0 11 0 0 11 11 11 3 Surfactant-associated protein 2 Ntox46 PF15538.6 EFA76627.1 - 0.00057 19.9 1.0 36 4.3 0.0 6.2 2 2 5 8 8 8 0 Bacterial toxin 46 Adeno_terminal PF02459.15 EFA76627.1 - 0.05 12.0 0.3 26 3.0 0.0 4.7 1 1 4 5 5 5 0 Adenoviral DNA terminal protein Dimerisation PF08100.11 EFA76627.1 - 0.1 12.7 4.4 79 3.4 0.0 6.2 10 0 0 10 10 10 0 Dimerisation domain DUF1966 PF09260.11 EFA76627.1 - 0.55 10.5 3.6 28 5.1 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1966) Cohesin_load PF10345.9 EFA76628.1 - 7.3e-06 24.7 4.4 1.4e-05 23.8 4.4 1.5 1 1 0 1 1 1 1 Cohesin loading factor EBA-175_VI PF11556.8 EFA76628.1 - 0.069 13.5 0.1 0.069 13.5 0.1 1.9 2 0 0 2 2 2 0 Erythrocyte binding antigen 175 TPR_12 PF13424.6 EFA76628.1 - 0.12 12.7 0.1 0.5 10.7 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF410 PF04190.13 EFA76629.1 - 0.00094 19.0 0.6 0.0011 18.8 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF986 PF06173.12 EFA76629.1 - 0.047 13.8 1.0 0.084 12.9 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF986) Dynamitin PF04912.14 EFA76630.1 - 1.3e-105 354.0 24.0 1.4e-105 353.8 24.0 1.0 1 0 0 1 1 1 1 Dynamitin Sec61_beta PF03911.16 EFA76630.1 - 4.2e-16 58.7 0.0 7.1e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Sec61beta family Pyr_redox PF00070.27 EFA76630.1 - 0.022 15.3 0.5 0.31 11.6 0.0 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase E2R135 PF11570.8 EFA76630.1 - 0.023 15.0 0.7 0.062 13.6 0.1 2.0 2 1 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF1664 PF07889.12 EFA76630.1 - 0.76 9.8 20.3 0.25 11.4 2.4 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.5 EFA76630.1 - 7.7 6.9 18.5 7.4 6.9 0.9 4.6 5 1 0 5 5 5 0 ABC transporter C-terminal domain FNIP PF05725.12 EFA76631.1 - 3e-23 81.7 3.6 4.9e-10 39.4 0.1 4.5 3 1 1 5 5 5 3 FNIP Repeat ANAPC4_WD40 PF12894.7 EFA76631.1 - 1.1e-09 38.5 2.7 0.0014 18.9 0.1 4.0 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA76631.1 - 3.6e-09 37.1 21.9 0.0014 19.4 1.6 6.5 7 0 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 EFA76631.1 - 0.0037 17.2 5.1 0.016 15.1 0.3 3.5 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A F-box_5 PF18511.1 EFA76631.1 - 0.029 14.0 0.2 0.26 10.9 0.0 2.4 2 0 0 2 2 2 0 F-box SnoaL_2 PF12680.7 EFA76631.1 - 0.11 13.2 0.1 0.23 12.1 0.1 1.5 1 0 0 1 1 1 0 SnoaL-like domain LytB_WW PF18342.1 EFA76631.1 - 0.17 12.0 0.2 9.6 6.4 0.0 2.5 2 0 0 2 2 2 0 Endo-beta-N-acetylglucosaminidase LytB WW domain Thioredoxin PF00085.20 EFA76633.1 - 6.2e-55 183.5 3.9 5.1e-27 93.9 0.1 4.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EFA76633.1 - 1.3e-37 129.5 8.9 6e-31 107.8 1.3 3.8 3 1 1 4 4 4 3 Thioredoxin-like domain Calsequestrin PF01216.17 EFA76633.1 - 2.7e-11 43.2 0.4 3.9e-10 39.3 0.1 2.3 2 0 0 2 2 2 1 Calsequestrin OST3_OST6 PF04756.13 EFA76633.1 - 3.2e-09 36.6 0.3 0.0011 18.4 0.0 3.0 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EFA76633.1 - 3.7e-09 36.6 0.1 0.031 14.5 0.0 4.0 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFA76633.1 - 1e-06 29.2 2.3 0.0089 16.5 0.0 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFA76633.1 - 1.3e-06 28.6 1.0 0.23 11.8 0.0 4.3 4 1 1 5 5 5 2 Thioredoxin-like ERp29_N PF07912.13 EFA76633.1 - 0.073 13.2 0.0 3.1 7.9 0.0 2.9 2 1 0 2 2 2 0 ERp29, N-terminal domain EGF_2 PF07974.13 EFA76634.1 - 0.00027 21.2 9.7 0.00064 20.0 9.7 1.6 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA76634.1 - 0.037 14.3 6.0 0.09 13.1 6.0 1.7 1 0 0 1 1 1 0 EGF-like domain GCD14 PF08704.10 EFA76635.1 - 5.2e-94 314.5 0.0 5.9e-94 314.3 0.0 1.0 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EFA76635.1 - 0.00017 21.4 0.0 0.00031 20.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFA76635.1 - 0.0005 19.9 0.0 0.0009 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EFA76635.1 - 0.0017 19.4 0.0 0.0028 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA76635.1 - 0.0062 17.2 0.0 0.01 16.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Fibrillarin PF01269.17 EFA76635.1 - 0.0066 15.6 0.0 0.016 14.3 0.0 1.5 1 1 0 1 1 1 1 Fibrillarin MTS PF05175.14 EFA76635.1 - 0.064 12.8 0.0 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EFA76635.1 - 0.075 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EFA76635.1 - 0.077 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) GCD14_N PF14801.6 EFA76636.1 - 1.9e-05 24.4 0.0 2.3e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Gcd10p PF04189.13 EFA76636.1 - 0.028 13.5 0.0 0.031 13.4 0.0 1.0 1 0 0 1 1 1 0 Gcd10p family RabGAP-TBC PF00566.18 EFA76638.1 - 6.2e-07 29.3 1.1 1.2e-06 28.4 1.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Histone PF00125.24 EFA76639.1 - 6.1e-33 114.0 0.3 7.5e-33 113.7 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RhoGAP PF00620.27 EFA76641.1 - 2.1e-18 66.6 0.0 2.7e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain V-SNARE_C PF12352.8 EFA76643.1 - 9.2e-06 25.9 3.7 2.4e-05 24.5 3.7 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFA76643.1 - 0.00037 20.3 1.5 0.00037 20.3 1.5 3.1 3 1 0 3 3 3 1 Sec20 SNARE PF05739.19 EFA76643.1 - 0.031 14.3 1.0 0.031 14.3 1.0 3.4 3 1 1 4 4 4 0 SNARE domain DUF3533 PF12051.8 EFA76643.1 - 0.07 12.1 0.8 0.092 11.7 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF3605 PF12239.8 EFA76643.1 - 0.2 12.0 2.6 0.22 11.8 1.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3605) AAA_11 PF13086.6 EFA76643.1 - 1.8 8.3 9.9 2.1 8.1 9.0 1.6 1 1 0 1 1 1 0 AAA domain Acetyltransf_1 PF00583.25 EFA76644.1 - 2.2e-08 34.4 0.0 3.4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA76644.1 - 6.1e-07 29.8 0.0 9.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA76644.1 - 1.8e-06 27.9 0.0 2.9e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GHMP_kinases_N PF00288.26 EFA76647.1 - 4.6e-14 52.4 0.6 1.1e-13 51.2 0.2 1.8 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFA76647.1 - 7.1e-06 26.3 0.0 2.1e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal Hpt PF01627.23 EFA76647.1 - 0.13 12.6 0.0 0.37 11.1 0.0 1.8 1 0 0 1 1 1 0 Hpt domain RNF220 PF15926.5 EFA76648.1 - 3.3e-19 69.5 12.3 3.3e-19 69.5 12.3 3.1 2 1 1 3 3 3 1 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.6 EFA76648.1 - 6e-10 38.8 10.7 6e-10 38.8 10.7 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA76648.1 - 7.2e-05 22.6 16.0 0.00076 19.3 9.0 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-CpG_bind_C PF12269.8 EFA76648.1 - 0.00038 20.3 10.9 0.05 13.4 0.2 3.3 3 0 0 3 3 3 2 CpG binding protein zinc finger C terminal domain PRP21_like_P PF12230.8 EFA76648.1 - 0.00068 19.6 3.5 0.00068 19.6 3.5 3.4 3 1 0 4 4 4 1 Pre-mRNA splicing factor PRP21 like protein zf-C3HC4 PF00097.25 EFA76648.1 - 0.0015 18.4 10.2 0.0015 18.4 10.2 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA76648.1 - 0.0066 16.4 8.1 0.0066 16.4 8.1 3.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_10 PF16685.5 EFA76648.1 - 0.059 13.5 11.5 0.42 10.8 7.1 2.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 EFA76648.1 - 0.065 13.1 16.4 0.58 10.1 9.2 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFA76648.1 - 0.15 12.5 19.4 0.036 14.4 11.7 2.9 3 0 0 3 3 3 0 Ring finger domain AT_hook PF02178.19 EFA76648.1 - 0.16 11.9 24.8 0.05 13.5 3.1 3.6 4 0 0 4 4 4 0 AT hook motif zf-ANAPC11 PF12861.7 EFA76648.1 - 0.6 10.2 8.6 0.59 10.2 5.7 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Sgf11 PF08209.11 EFA76648.1 - 0.62 9.7 4.2 1.7 8.3 0.1 3.1 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-C3HC4_4 PF15227.6 EFA76648.1 - 7.7 6.8 13.0 5.8 7.2 9.9 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EFA76648.1 - 9.5 6.3 15.6 0.9 9.6 8.5 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Methyltransf_11 PF08241.12 EFA76649.1 - 4.7e-15 56.0 0.1 1.1e-14 54.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA76649.1 - 8.9e-13 48.3 0.0 1.5e-12 47.6 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA76649.1 - 2.8e-12 47.2 0.1 7.5e-12 45.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA76649.1 - 3.5e-08 33.1 0.1 4.6e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFA76649.1 - 9.4e-08 32.7 0.0 1.9e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA76649.1 - 0.029 14.2 0.0 0.063 13.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EFA76649.1 - 0.03 14.2 0.0 0.5 10.2 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_29 PF03141.16 EFA76649.1 - 0.037 12.6 0.0 0.039 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ank_2 PF12796.7 EFA76650.1 - 1.6e-22 79.9 5.2 6.8e-11 42.6 0.6 5.8 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76650.1 - 1.1e-20 73.7 7.1 3.5e-06 27.5 0.1 8.4 7 2 1 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76650.1 - 1.2e-17 63.7 5.2 0.0015 18.8 0.2 9.6 4 1 7 11 11 11 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76650.1 - 7.1e-12 44.4 3.2 7.2 7.5 0.0 10.6 11 0 0 11 11 11 2 Ankyrin repeat Ank PF00023.30 EFA76650.1 - 0.00036 20.8 3.3 4.1 8.0 0.0 6.0 5 3 2 7 7 7 1 Ankyrin repeat DUF3447 PF11929.8 EFA76650.1 - 0.23 11.5 16.9 0.06 13.3 0.7 4.7 3 2 2 5 5 5 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA76651.1 - 2.2e-26 92.3 19.8 3.6e-10 40.3 0.4 6.4 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76651.1 - 2.5e-22 78.9 14.4 6.8e-07 29.7 0.1 8.1 8 2 1 9 9 9 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76651.1 - 1.1e-18 67.1 9.9 0.0013 19.0 0.1 9.8 3 2 7 10 10 10 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76651.1 - 8.3e-18 62.6 9.5 2.5 8.9 0.0 12.2 13 1 1 14 14 14 5 Ankyrin repeat Ank PF00023.30 EFA76651.1 - 5.4e-06 26.6 4.1 2.3 8.8 0.0 6.5 5 2 2 7 7 7 1 Ankyrin repeat Lipase_3 PF01764.25 EFA76653.1 - 5e-35 120.4 0.0 7.2e-35 119.9 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EFA76653.1 - 1.2e-05 25.0 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 EFA76653.1 - 0.0028 18.3 0.0 0.0035 18.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family zf-RING_7 PF02591.15 EFA76653.1 - 0.054 13.7 1.6 0.23 11.7 0.0 2.3 2 0 0 2 2 2 0 C4-type zinc ribbon domain zf_UBZ PF18439.1 EFA76653.1 - 0.089 12.4 1.1 2.5 7.8 0.0 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Cutinase PF01083.22 EFA76653.1 - 0.13 12.2 0.1 0.4 10.6 0.0 1.7 2 0 0 2 2 2 0 Cutinase Abhydrolase_5 PF12695.7 EFA76653.1 - 0.16 11.7 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family NT-C2 PF10358.9 EFA76654.1 - 9.3e-11 41.6 0.1 2e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EFA76654.1 - 1.6e-06 28.3 0.1 3.8e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 DIL domain Ank_4 PF13637.6 EFA76655.1 - 4.3e-29 100.5 19.2 9.5e-05 22.9 0.0 10.8 8 2 2 10 10 10 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA76655.1 - 4.9e-28 97.5 13.9 2.6e-09 37.6 0.1 7.7 3 2 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA76655.1 - 4e-22 78.0 13.0 0.11 12.8 0.0 12.8 5 4 9 14 14 14 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76655.1 - 8.6e-18 62.6 15.3 3.5 8.5 0.0 15.3 17 1 1 18 18 18 3 Ankyrin repeat DUF3447 PF11929.8 EFA76655.1 - 0.00029 20.7 29.3 0.7 9.9 4.3 7.7 3 2 5 8 8 8 3 Domain of unknown function (DUF3447) DUF5049 PF16468.5 EFA76655.1 - 0.026 14.4 0.0 0.76 9.7 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA76655.1 - 0.073 13.5 0.2 4.5e+02 1.6 0.1 5.7 5 1 0 5 5 5 0 Ankyrin repeat AbiJ_NTD4 PF18863.1 EFA76655.1 - 0.13 12.7 0.2 0.13 12.7 0.2 4.0 3 1 1 4 4 4 0 AbiJ N-terminal domain 4 DUF285 PF03382.14 EFA76656.1 - 0.0077 16.0 0.3 0.01 15.6 0.3 1.1 1 0 0 1 1 1 1 Mycoplasma protein of unknown function, DUF285 Acetyltransf_3 PF13302.7 EFA76657.1 - 1.8e-26 93.5 0.0 4.9e-26 92.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA76657.1 - 7.1e-07 29.5 0.0 1.7e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EFA76657.1 - 1.2e-05 25.5 0.1 0.00013 22.2 0.0 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Ank_3 PF13606.6 EFA76657.1 - 0.016 15.7 0.4 24 5.9 0.0 5.1 5 0 0 5 5 5 0 Ankyrin repeat Ank_5 PF13857.6 EFA76657.1 - 0.15 12.4 0.1 5.6 7.4 0.0 3.3 3 1 1 4 4 4 0 Ankyrin repeats (many copies) FR47 PF08445.10 EFA76657.1 - 0.18 11.8 0.0 0.42 10.6 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein SNARE PF05739.19 EFA76658.1 - 0.00024 21.0 0.0 0.00048 20.1 0.0 1.5 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.9 EFA76658.1 - 0.0035 17.1 0.3 0.0043 16.8 0.3 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Fusion_gly PF00523.18 EFA76658.1 - 0.051 11.8 0.3 0.059 11.6 0.3 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 UcrQ PF02939.16 EFA76658.1 - 0.098 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 UcrQ family Synaptobrevin PF00957.21 EFA76658.1 - 0.13 12.0 4.7 0.58 10.0 2.1 2.3 1 1 1 2 2 2 0 Synaptobrevin ERG2_Sigma1R PF04622.12 EFA76659.1 - 2e-07 30.6 0.2 4.5e-07 29.4 0.0 1.6 1 1 1 2 2 2 1 ERG2 and Sigma1 receptor like protein Clat_adaptor_s PF01217.20 EFA76661.1 - 5.1e-53 178.8 0.4 5.6e-53 178.7 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Methyltransf_11 PF08241.12 EFA76662.1 - 1.3e-10 41.8 0.0 2.6e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA76662.1 - 1.3e-09 38.0 0.0 3e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA76662.1 - 3.2e-08 34.2 0.0 8.9e-08 32.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA76662.1 - 0.0038 17.9 0.0 0.01 16.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Lipoprotein_17 PF04200.12 EFA76662.1 - 5.9 7.3 14.1 1.5 9.2 5.9 2.6 2 0 0 2 2 2 0 Lipoprotein associated domain AF-4 PF05110.13 EFA76663.1 - 0.12 10.5 22.3 0.14 10.2 22.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF2185 PF09951.9 EFA76663.1 - 2.1 8.2 8.6 0.89 9.4 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2185) Mucin PF01456.17 EFA76664.1 - 0.41 10.6 17.6 0.5 10.3 17.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 EFA76664.1 - 4.8 7.6 19.4 7.4 7.0 19.4 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin NST1 PF13945.6 EFA76664.1 - 7.2 6.7 22.8 9.7 6.2 22.8 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator zf-B_box PF00643.24 EFA76665.1 - 2.2e-06 27.7 10.6 2.2e-06 27.7 10.6 3.2 4 0 0 4 4 4 1 B-box zinc finger Kelch_6 PF13964.6 EFA76665.1 - 0.0038 17.5 0.3 0.017 15.4 0.3 2.2 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 EFA76665.1 - 0.031 13.8 0.1 0.086 12.4 0.1 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 EFA76665.1 - 0.14 12.2 0.9 0.4 10.7 0.3 2.1 2 0 0 2 2 2 0 Kelch motif LsmAD PF06741.13 EFA76666.1 - 1.6e-24 86.2 3.4 1.6e-24 86.2 3.4 2.0 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 EFA76666.1 - 5.3e-16 58.5 0.0 1.3e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 EFA76666.1 - 4.7e-05 22.8 7.1 0.00039 19.9 0.9 2.8 1 1 1 2 2 2 2 Ataxin-2 C-terminal region LSM PF01423.22 EFA76666.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 LSM domain RRM_1 PF00076.22 EFA76667.1 - 0.0025 17.6 0.1 0.011 15.5 0.0 2.2 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA76667.1 - 0.019 14.8 0.8 0.26 11.2 0.1 2.9 2 1 0 2 2 2 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EFA76667.1 - 0.051 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PTH2 PF01981.16 EFA76667.1 - 0.24 11.7 2.1 0.46 10.8 0.7 2.2 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 TRAP_alpha PF03896.16 EFA76667.1 - 0.48 9.6 10.9 0.95 8.6 10.9 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BCAS3 PF12490.8 EFA76669.1 - 1.7e-07 31.0 8.4 0.00032 20.3 0.1 3.1 2 1 1 3 3 3 2 Breast carcinoma amplified sequence 3 Spore_GerAC PF05504.11 EFA76669.1 - 0.4 10.9 2.4 1 9.5 2.4 1.6 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal RT_RNaseH_2 PF17919.1 EFA76670.1 - 0.00023 21.2 0.3 0.00064 19.7 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA76670.1 - 0.0003 21.0 0.0 0.00095 19.4 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase SieB PF14163.6 EFA76670.1 - 0.0083 15.6 0.8 0.0083 15.6 0.8 2.1 2 0 0 2 2 2 1 Super-infection exclusion protein B DUF2115 PF09888.9 EFA76670.1 - 0.016 15.8 0.1 0.016 15.8 0.1 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) HEAT_2 PF13646.6 EFA76670.1 - 0.025 15.0 0.2 3.3 8.2 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats TPR_17 PF13431.6 EFA76671.1 - 1.8e-103 331.8 30.5 4.3e-10 39.3 0.1 11.7 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76671.1 - 2.3e-16 59.2 47.3 0.018 14.7 0.8 10.5 11 0 0 11 11 11 8 TPR repeat Anth_Ig PF05587.13 EFA76671.1 - 0.00012 22.3 9.7 29 5.1 0.0 8.0 9 0 0 9 9 9 0 Anthrax receptor extracellular domain RAP80_UIM PF18282.1 EFA76671.1 - 0.00098 18.8 0.0 7.7 6.4 0.0 5.5 6 0 0 6 6 6 1 RAP80 N-terminal ubiquitin interaction motif P22_CoatProtein PF11651.8 EFA76671.1 - 0.0041 15.8 0.2 3.8 6.0 0.0 3.6 3 1 1 4 4 4 1 P22 coat protein - gene protein 5 DUF1344 PF07076.11 EFA76671.1 - 0.0047 16.8 14.8 29 4.7 0.1 8.1 9 0 0 9 9 9 0 Protein of unknown function (DUF1344) Endotoxin_C PF03944.14 EFA76671.1 - 0.016 15.5 13.5 1 9.7 0.6 5.0 3 2 1 4 4 4 0 delta endotoxin Peptidase_A4 PF01828.17 EFA76671.1 - 0.03 13.8 0.0 4.8 6.6 0.0 3.1 2 1 1 3 3 3 0 Peptidase A4 family NleF_casp_inhib PF16809.5 EFA76671.1 - 0.057 13.3 13.8 44 3.9 0.1 7.9 5 2 5 10 10 10 0 NleF caspase inhibitor GST_C_3 PF14497.6 EFA76672.1 - 2e-15 56.8 0.0 3.8e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA76672.1 - 2e-09 37.7 0.0 4.3e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA76672.1 - 0.00017 21.7 0.0 0.00034 20.8 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA76672.1 - 0.00074 19.9 0.0 0.0018 18.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFA76672.1 - 0.098 12.5 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MukF_M PF17192.4 EFA76672.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 MukF middle domain GST_C_2 PF13410.6 EFA76672.1 - 0.15 12.1 0.0 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GATA PF00320.27 EFA76673.1 - 1.8e-14 53.1 5.2 1.8e-14 53.0 3.6 1.9 2 0 0 2 2 2 1 GATA zinc finger zinc_ribbon_9 PF14369.6 EFA76673.1 - 0.16 12.3 0.1 0.33 11.2 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon UQ_con PF00179.26 EFA76674.1 - 2.8e-32 111.3 0.0 3.3e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 EFA76674.1 - 0.035 13.7 0.0 0.069 12.8 0.0 1.7 1 1 1 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 Glyco_hydro_25 PF01183.20 EFA76677.1 - 3.3e-08 33.9 0.0 5.7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DUF1906 PF08924.11 EFA76677.1 - 0.00083 19.5 0.1 0.0017 18.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1906) DUF349 PF03993.12 EFA76677.1 - 0.048 13.9 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) HalX PF08663.10 EFA76677.1 - 0.099 13.0 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 HalX domain Mt_ATP-synt_D PF05873.12 EFA76677.1 - 0.22 11.4 1.4 0.29 11.0 0.3 1.6 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) FadA PF09403.10 EFA76677.1 - 0.64 10.5 3.3 15 6.1 0.2 2.4 2 0 0 2 2 2 0 Adhesion protein FadA PFU PF09070.11 EFA76678.1 - 1e-36 125.6 2.5 2.1e-36 124.6 2.5 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EFA76678.1 - 8.1e-34 115.1 21.4 4.5e-07 30.5 0.6 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat PUL PF08324.11 EFA76678.1 - 6.5e-22 78.1 3.9 3.5e-14 52.7 0.4 2.3 1 1 1 2 2 2 2 PUL domain PQQ_3 PF13570.6 EFA76678.1 - 0.26 11.8 3.6 86 3.8 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain FNIP PF05725.12 EFA76680.1 - 2.9e-20 72.1 31.6 1.8e-13 50.4 0.5 6.5 6 1 0 6 6 6 3 FNIP Repeat F-box_5 PF18511.1 EFA76680.1 - 0.0086 15.6 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA76680.1 - 0.049 13.5 0.1 0.17 11.8 0.1 1.9 1 0 0 1 1 1 0 F-box-like adh_short PF00106.25 EFA76681.1 - 1.5e-43 148.5 0.9 6.9e-43 146.4 0.9 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA76681.1 - 2e-32 112.6 0.1 6.3e-32 111.0 0.1 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA76681.1 - 1.6e-07 31.4 0.0 2.8e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFA76681.1 - 4.2e-06 26.3 0.3 4.7e-05 22.9 0.3 2.2 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Rax2 PF12768.7 EFA76681.1 - 0.0012 18.4 0.6 0.13 11.7 0.2 2.2 2 0 0 2 2 2 2 Cortical protein marker for cell polarity Epimerase PF01370.21 EFA76681.1 - 0.022 14.2 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family TatD_DNase PF01026.21 EFA76682.1 - 8.7e-44 149.8 0.0 2e-43 148.6 0.0 1.6 1 0 0 1 1 1 1 TatD related DNase Dicty_REP PF05086.12 EFA76682.1 - 0.0022 16.1 14.1 0.0022 16.1 14.1 1.5 2 0 0 2 2 2 1 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 EFA76682.1 - 0.16 11.9 20.9 0.34 10.9 20.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein PGA2 PF07543.12 EFA76682.1 - 1.2 9.1 15.1 0.31 11.0 8.3 2.6 2 0 0 2 2 2 0 Protein trafficking PGA2 Yippee-Mis18 PF03226.14 EFA76682.1 - 1.5 9.0 7.8 0.17 12.1 1.0 2.4 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Cwf_Cwc_15 PF04889.12 EFA76682.1 - 2.2 7.9 25.4 1.1 9.0 14.9 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Peptidase_M28 PF04389.17 EFA76683.1 - 2e-19 70.1 0.0 5e-19 68.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 Sld5 PF05916.11 EFA76683.1 - 2e-17 63.7 0.1 6.5e-17 62.0 0.1 1.9 1 0 0 1 1 1 1 GINS complex protein DUF3439 PF11921.8 EFA76683.1 - 6 6.9 9.5 4.8 7.2 7.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) AAA PF00004.29 EFA76684.1 - 3e-49 166.8 1.1 6.8e-33 113.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA76684.1 - 4e-17 61.7 0.0 4e-10 39.3 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFA76684.1 - 4e-11 43.6 0.3 0.0011 19.3 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 EFA76684.1 - 2.2e-09 37.6 0.0 0.0034 17.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EFA76684.1 - 5.8e-09 35.9 0.0 0.00029 20.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFA76684.1 - 3.6e-08 33.0 0.2 0.0045 16.3 0.1 2.7 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EFA76684.1 - 2.5e-07 31.0 0.8 0.062 13.6 0.1 4.4 2 1 1 3 3 3 2 AAA domain AAA_5 PF07728.14 EFA76684.1 - 1.8e-06 28.0 0.1 0.0023 17.9 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFA76684.1 - 1.9e-06 28.5 7.5 0.0055 17.3 0.0 4.2 4 0 0 4 4 4 2 AAA domain IstB_IS21 PF01695.17 EFA76684.1 - 2e-05 24.4 0.0 0.034 13.9 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 EFA76684.1 - 0.00016 21.7 0.2 1.5 8.8 0.0 3.3 3 1 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EFA76684.1 - 0.0003 20.3 0.0 0.19 11.1 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EFA76684.1 - 0.00047 20.5 2.9 1.3 9.4 0.0 4.1 4 1 1 5 5 2 2 RNA helicase Zeta_toxin PF06414.12 EFA76684.1 - 0.00048 19.5 0.1 0.41 9.9 0.0 2.6 2 1 0 2 2 2 2 Zeta toxin Sigma54_activat PF00158.26 EFA76684.1 - 0.00061 19.5 0.0 0.16 11.6 0.0 2.9 3 0 0 3 3 2 1 Sigma-54 interaction domain Prefoldin_3 PF13758.6 EFA76684.1 - 0.00066 19.7 3.5 0.081 13.0 0.1 4.4 3 1 0 3 3 3 1 Prefoldin subunit Cytidylate_kin PF02224.18 EFA76684.1 - 0.0007 19.4 0.8 0.2 11.4 0.0 3.5 3 0 0 3 3 3 1 Cytidylate kinase AAA_17 PF13207.6 EFA76684.1 - 0.00076 19.9 1.0 2.5 8.5 0.0 3.6 3 1 0 3 3 3 2 AAA domain Sigma54_activ_2 PF14532.6 EFA76684.1 - 0.00078 19.6 0.0 0.67 10.1 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 EFA76684.1 - 0.00091 19.3 18.7 0.0019 18.2 0.0 5.1 4 1 1 5 5 5 2 AAA domain T2SSE PF00437.20 EFA76684.1 - 0.0015 17.6 0.0 0.061 12.4 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_28 PF13521.6 EFA76684.1 - 0.0017 18.6 0.0 0.97 9.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.10 EFA76684.1 - 0.0031 17.5 0.1 0.011 15.7 0.1 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 EFA76684.1 - 0.0043 16.6 0.0 0.37 10.3 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 EFA76684.1 - 0.0056 16.4 2.7 0.4 10.4 0.0 3.7 4 0 0 4 4 4 1 AAA domain ABC_tran PF00005.27 EFA76684.1 - 0.0071 16.9 8.2 0.04 14.4 0.2 3.6 4 0 0 4 4 3 1 ABC transporter PhoH PF02562.16 EFA76684.1 - 0.012 15.1 0.0 0.3 10.5 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.12 EFA76684.1 - 0.014 15.4 0.0 4.4 7.2 0.0 3.1 2 1 1 3 3 3 0 NACHT domain ATPase PF06745.13 EFA76684.1 - 0.022 14.1 2.5 0.37 10.1 0.0 3.4 2 2 1 3 3 3 0 KaiC Zot PF05707.12 EFA76684.1 - 0.029 14.0 1.1 1.1 8.9 0.1 3.2 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_25 PF13481.6 EFA76684.1 - 0.037 13.6 0.4 4.7 6.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain ERbeta_N PF12497.8 EFA76684.1 - 0.054 13.3 0.2 0.26 11.1 0.2 2.1 2 0 0 2 2 1 0 Estrogen receptor beta AAA_30 PF13604.6 EFA76684.1 - 0.12 12.1 0.0 1.3 8.7 0.0 2.5 3 0 0 3 3 2 0 AAA domain WD40 PF00400.32 EFA76685.1 - 5.2e-07 30.3 9.0 0.0047 17.7 0.1 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76685.1 - 8.9e-07 29.1 0.5 0.00018 21.7 0.3 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_12 PF13424.6 EFA76686.1 - 7.4e-36 122.3 13.1 2.3e-13 50.2 0.2 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat DUF4062 PF13271.6 EFA76686.1 - 6.3e-13 48.9 0.0 6.3e-13 48.9 0.0 2.7 2 0 0 2 2 1 1 Domain of unknown function (DUF4062) TPR_10 PF13374.6 EFA76686.1 - 4.3e-12 45.5 13.9 0.0032 17.3 0.0 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFA76686.1 - 1.6e-08 34.0 15.7 0.0033 17.2 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat NACHT PF05729.12 EFA76686.1 - 1.6e-08 34.6 0.0 1.6e-08 34.6 0.0 2.7 2 1 0 2 2 1 1 NACHT domain TIG PF01833.24 EFA76686.1 - 2.7e-08 33.7 2.4 2.7e-08 33.7 2.4 2.0 2 0 0 2 2 2 1 IPT/TIG domain TPR_2 PF07719.17 EFA76686.1 - 1.2e-06 28.2 17.1 0.054 13.6 0.0 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat BRCT PF00533.26 EFA76686.1 - 2.4e-05 24.6 2.1 6.5e-05 23.2 0.1 2.6 3 0 0 3 3 2 1 BRCA1 C Terminus (BRCT) domain TPR_8 PF13181.6 EFA76686.1 - 4.3e-05 23.4 17.5 0.099 12.9 0.2 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat AAA_16 PF13191.6 EFA76686.1 - 5.2e-05 23.7 0.0 5.2e-05 23.7 0.0 3.3 3 0 0 3 3 2 1 AAA ATPase domain BRCT_2 PF16589.5 EFA76686.1 - 0.0002 21.7 0.4 0.00073 19.9 0.4 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain TPR_7 PF13176.6 EFA76686.1 - 0.00031 20.5 7.2 1.4 9.1 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat PTCB-BRCT PF12738.7 EFA76686.1 - 0.00077 19.4 0.0 0.002 18.0 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain AAA_22 PF13401.6 EFA76686.1 - 0.00098 19.4 1.1 0.005 17.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain DUF2225 PF09986.9 EFA76686.1 - 0.0018 18.1 5.8 0.42 10.3 0.1 3.6 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) ATPase_2 PF01637.18 EFA76686.1 - 0.002 18.1 0.0 0.0099 15.8 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea ThiF PF00899.21 EFA76686.1 - 0.086 12.2 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 ThiF family Mo25 PF08569.11 EFA76686.1 - 2 7.7 11.1 21 4.3 0.1 3.2 2 0 0 2 2 2 0 Mo25-like TFIIA PF03153.13 EFA76686.1 - 7.2 6.5 60.3 1 9.3 51.3 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit 7tm_3 PF00003.22 EFA76687.1 - 3.5e-22 79.3 22.1 7.3e-22 78.3 22.1 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4524 PF15025.6 EFA76687.1 - 0.11 12.3 0.0 0.31 10.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4524) CorA PF01544.18 EFA76688.1 - 1.2e-41 143.0 5.0 1.2e-41 143.0 5.0 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein LAGLIDADG_2 PF03161.13 EFA76688.1 - 0.013 15.5 1.1 0.03 14.4 0.4 1.9 2 0 0 2 2 2 0 LAGLIDADG DNA endonuclease family DUF4065 PF13274.6 EFA76688.1 - 0.58 11.1 8.2 2 9.3 0.1 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4065) PH_8 PF15409.6 EFA76689.1 - 0.073 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Copper-bind PF00127.20 EFA76689.1 - 0.12 12.9 0.4 0.2 12.1 0.4 1.4 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family LRAT PF04970.13 EFA76690.1 - 0.00048 20.4 0.8 0.0012 19.1 0.1 1.9 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 EFA76690.1 - 0.002 18.0 0.5 0.002 18.0 0.5 1.9 1 1 1 2 2 2 1 PPPDE putative peptidase domain DUF687 PF05095.12 EFA76690.1 - 0.013 14.1 0.6 0.018 13.6 0.1 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF687) Phage_TTP_1 PF04630.12 EFA76690.1 - 0.016 14.5 5.7 0.018 14.4 5.7 1.0 1 0 0 1 1 1 0 Phage tail tube protein Med3 PF11593.8 EFA76690.1 - 0.057 12.6 7.1 0.067 12.4 7.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Sec7_N PF12783.7 EFA76690.1 - 0.072 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal zf-C2H2_4 PF13894.6 EFA76691.1 - 0.45 11.5 0.1 0.45 11.5 0.1 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger Ocular_alb PF02101.15 EFA76691.1 - 3 6.7 5.2 2.1 7.1 3.0 1.8 1 1 0 1 1 1 0 Ocular albinism type 1 protein MRP-S33 PF08293.11 EFA76694.1 - 8.1e-07 29.2 1.2 3.5e-06 27.2 1.2 1.8 1 1 0 1 1 1 1 Mitochondrial ribosomal subunit S27 DUF687 PF05095.12 EFA76695.1 - 0.013 14.1 0.1 0.025 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF687) Rrp15p PF07890.12 EFA76696.1 - 7.1e-16 58.8 11.8 7.1e-16 58.8 11.8 3.1 1 1 1 2 2 2 1 Rrp15p DER1 PF04511.15 EFA76697.1 - 6.7e-48 163.2 12.6 8.1e-48 162.9 12.6 1.1 1 0 0 1 1 1 1 Der1-like family Gpi1 PF05024.15 EFA76697.1 - 2.2 8.3 8.7 0.48 10.5 0.8 2.2 2 0 0 2 2 2 0 N-acetylglucosaminyl transferase component (Gpi1) ORMDL PF04061.14 EFA76698.1 - 6.8e-45 152.2 1.2 7.6e-45 152.0 1.2 1.0 1 0 0 1 1 1 1 ORMDL family ERO1 PF04137.15 EFA76699.1 - 8e-114 380.5 1.0 8e-114 380.5 1.0 1.7 3 0 0 3 3 3 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DUF2615 PF11027.8 EFA76699.1 - 0.0011 19.1 0.8 0.0056 16.8 0.8 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) Metallothio_11 PF02066.15 EFA76699.1 - 0.18 12.0 0.1 0.18 12.0 0.1 3.3 3 0 0 3 3 3 0 Metallothionein family 11 PDEase_I PF00233.19 EFA76700.1 - 1.7e-28 100.0 0.3 1.7e-28 100.0 0.3 2.3 3 0 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.24 EFA76700.1 - 0.001 19.2 0.1 0.0034 17.5 0.1 2.0 1 0 0 1 1 1 1 Response regulator receiver domain PKcGMP_CC PF16808.5 EFA76700.1 - 0.02 14.7 2.3 0.065 13.1 2.3 1.9 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CDO_I PF05995.12 EFA76701.1 - 0.00057 19.2 0.0 0.00098 18.5 0.0 1.3 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EFA76701.1 - 0.13 11.7 2.7 0.56 9.6 2.7 2.0 1 1 0 1 1 1 0 PCO_ADO zf-FLZ PF04570.14 EFA76702.1 - 0.12 11.9 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF3941 PF13081.6 EFA76702.1 - 0.13 12.7 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3941) FNIP PF05725.12 EFA76703.1 - 6.5e-17 61.4 4.3 3e-09 36.9 0.1 5.4 4 1 1 5 5 5 3 FNIP Repeat F-box_5 PF18511.1 EFA76703.1 - 0.00011 21.7 0.1 0.00021 20.8 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA76703.1 - 0.00083 19.2 0.4 0.0015 18.4 0.4 1.4 1 0 0 1 1 1 1 F-box-like Snurportin1 PF11538.8 EFA76704.1 - 0.0017 18.5 5.1 0.0017 18.5 5.1 2.3 2 0 0 2 2 2 1 Snurportin1 SUIM_assoc PF16619.5 EFA76704.1 - 0.0044 17.1 4.9 0.0044 17.1 4.9 2.8 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 WDCP PF15390.6 EFA76704.1 - 0.33 9.3 12.1 0.43 8.9 12.1 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SLX9 PF15341.6 EFA76704.1 - 0.59 10.5 14.3 0.53 10.7 12.9 1.6 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 V_ATPase_I PF01496.19 EFA76704.1 - 2.6 5.9 14.0 3.5 5.4 14.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DEAD PF00270.29 EFA76705.1 - 2.6e-43 147.8 3.5 6.1e-43 146.6 0.0 3.2 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA76705.1 - 1.2e-30 106.1 0.2 5.6e-30 104.0 0.2 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Kelch_6 PF13964.6 EFA76705.1 - 2.8e-12 46.4 2.1 4.2e-07 30.0 0.0 4.3 3 1 1 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EFA76705.1 - 0.0023 17.9 4.2 0.13 12.3 0.3 3.8 4 0 0 4 4 4 1 Kelch motif zf-B_box PF00643.24 EFA76705.1 - 0.0094 16.1 10.6 0.0094 16.1 10.6 1.9 2 0 0 2 2 2 1 B-box zinc finger Kelch_1 PF01344.25 EFA76705.1 - 0.12 12.0 7.3 0.15 11.7 0.1 3.8 4 0 0 4 4 4 0 Kelch motif DUF5305 PF17231.2 EFA76707.1 - 6.5e-05 22.4 0.1 0.00012 21.5 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5305) MARVEL PF01284.23 EFA76707.1 - 0.0015 18.6 8.1 0.0063 16.6 8.1 2.0 1 1 0 1 1 1 1 Membrane-associating domain DUF2615 PF11027.8 EFA76707.1 - 0.032 14.4 0.8 0.17 12.1 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) DUF898 PF05987.13 EFA76707.1 - 0.034 13.2 1.4 0.056 12.5 1.2 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) TMCO5 PF14992.6 EFA76707.1 - 0.035 13.7 0.3 0.052 13.1 0.3 1.3 1 0 0 1 1 1 0 TMCO5 family TMEM154 PF15102.6 EFA76707.1 - 0.062 13.2 0.5 0.97 9.3 0.4 2.1 1 1 1 2 2 2 0 TMEM154 protein family DUF1218 PF06749.12 EFA76707.1 - 0.32 11.5 0.2 0.32 11.5 0.2 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF1218) Ost5 PF05251.12 EFA76707.1 - 1.7 9.0 15.2 4.7 7.5 0.1 3.8 3 1 1 4 4 4 0 Oligosaccharyltransferase subunit 5 DUF2721 PF11026.8 EFA76707.1 - 1.8 8.5 11.3 0.033 14.1 2.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) DHHC PF01529.20 EFA76707.1 - 6.9 6.8 9.9 2.4 8.3 3.8 2.3 1 1 2 3 3 3 0 DHHC palmitoyltransferase TPR_1 PF00515.28 EFA76708.1 - 4.8e-33 111.6 4.8 3e-06 26.8 0.0 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76708.1 - 1.9e-31 105.6 1.4 3e-05 23.8 0.1 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76708.1 - 1.7e-27 93.3 5.0 0.00066 19.7 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76708.1 - 9.3e-26 90.1 1.4 9.1e-08 32.5 0.0 5.8 3 1 4 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76708.1 - 7.8e-23 80.9 0.0 1e-06 29.2 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76708.1 - 1.5e-22 79.6 1.6 3.7e-07 30.3 0.0 5.4 4 2 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFA76708.1 - 2.7e-19 68.2 3.0 0.072 14.0 0.0 7.6 2 2 6 8 8 8 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA76708.1 - 4.7e-18 65.2 0.1 3.7e-06 27.1 0.0 3.8 3 1 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFA76708.1 - 7.7e-18 63.1 2.1 0.013 15.5 0.0 5.8 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76708.1 - 2.6e-14 52.6 2.1 0.0038 16.9 0.2 6.0 5 1 1 6 6 6 3 TPR repeat TPR_17 PF13431.6 EFA76708.1 - 1.2e-11 44.1 0.0 1 9.9 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFA76708.1 - 2.2e-11 43.8 0.4 0.023 14.8 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_15 PF13429.6 EFA76708.1 - 1.4e-10 40.9 0.0 1.3e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA76708.1 - 2.7e-10 40.2 3.2 0.061 14.0 0.0 6.9 7 0 0 7 7 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA76708.1 - 2e-09 37.3 0.2 1.5e-05 24.9 0.1 3.6 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EFA76708.1 - 2.4e-07 30.4 0.3 1.6 8.7 0.2 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 EFA76708.1 - 0.00013 21.8 0.3 0.088 12.5 0.0 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat-like domain BTAD PF03704.17 EFA76708.1 - 0.00035 21.0 1.2 1.1 9.7 0.2 3.3 2 1 0 3 3 3 1 Bacterial transcriptional activator domain TPR_MalT PF17874.1 EFA76708.1 - 0.0014 18.1 0.0 0.019 14.4 0.0 2.7 2 1 1 3 3 3 1 MalT-like TPR region Coatomer_E PF04733.14 EFA76708.1 - 0.002 17.6 1.0 0.026 13.9 0.2 2.5 2 0 0 2 2 2 1 Coatomer epsilon subunit ChAPs PF09295.10 EFA76708.1 - 0.017 14.2 0.7 3 6.8 0.1 2.9 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Alkyl_sulf_dimr PF14863.6 EFA76708.1 - 0.028 14.9 1.0 3.4 8.1 0.0 3.3 4 0 0 4 4 3 0 Alkyl sulfatase dimerisation SNAP PF14938.6 EFA76708.1 - 0.046 13.1 0.0 11 5.3 0.0 3.3 3 1 0 3 3 2 0 Soluble NSF attachment protein, SNAP PPR PF01535.20 EFA76708.1 - 0.081 13.2 1.1 67 4.1 0.0 4.2 4 0 0 4 4 4 0 PPR repeat TPR_5 PF12688.7 EFA76708.1 - 0.087 13.1 2.5 2.1 8.6 0.0 3.6 4 0 0 4 4 4 0 Tetratrico peptide repeat NARP1 PF12569.8 EFA76708.1 - 0.12 11.2 7.3 3.4 6.4 0.0 3.5 3 1 0 4 4 4 0 NMDA receptor-regulated protein 1 Pap_E4 PF02711.14 EFA76708.1 - 1 10.4 12.0 2.3 9.2 12.0 1.6 1 0 0 1 1 1 0 E4 protein DUF1180 PF06679.12 EFA76708.1 - 1.4 9.3 8.4 2.7 8.4 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3915 PF13054.6 EFA76709.1 - 3.6e-05 23.7 3.4 3.6e-05 23.7 3.4 4.3 4 1 1 5 5 5 2 Protein of unknown function (DUF3915) SUIM_assoc PF16619.5 EFA76709.1 - 0.00033 20.7 1.1 0.00033 20.7 1.1 6.1 4 2 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 PRP38_assoc PF12871.7 EFA76709.1 - 0.0022 18.6 52.3 0.062 13.9 34.4 2.8 2 0 0 2 2 2 2 Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-RING_5 PF14634.6 EFA76709.1 - 0.13 12.2 6.9 0.29 11.1 6.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EFA76709.1 - 0.2 12.0 6.0 0.39 11.1 6.0 1.5 1 0 0 1 1 1 0 Ring finger domain Peptidase_S9_N PF02897.15 EFA76710.1 - 8.5e-97 324.6 0.7 1.1e-96 324.2 0.7 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 EFA76710.1 - 6.3e-60 202.3 0.0 9.2e-60 201.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family FNIP PF05725.12 EFA76711.1 - 4.5e-24 84.3 24.9 1.7e-09 37.7 0.4 8.4 7 1 1 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA76711.1 - 3.3e-05 23.3 0.2 7.6e-05 22.2 0.2 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA76711.1 - 0.016 15.1 0.3 0.054 13.4 0.3 1.9 1 0 0 1 1 1 0 F-box-like Acetyltransf_10 PF13673.7 EFA76712.1 - 6e-13 48.8 0.0 8.2e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA76712.1 - 4.5e-09 36.6 0.0 5.2e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA76712.1 - 3.4e-08 33.8 0.0 4.9e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFA76712.1 - 0.026 14.6 0.0 0.041 14.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFA76712.1 - 0.044 13.9 0.0 0.088 12.9 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Erv26 PF04148.13 EFA76713.1 - 2e-43 148.6 25.9 1.3e-42 145.9 25.9 1.8 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 DUF3810 PF12725.7 EFA76713.1 - 0.54 9.6 11.7 1.2 8.4 3.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3810) MARVEL PF01284.23 EFA76713.1 - 4 7.5 24.2 0.56 10.2 4.5 2.4 1 1 0 2 2 2 0 Membrane-associating domain Cpn60_TCP1 PF00118.24 EFA76714.1 - 1.4e-155 518.6 2.4 1.7e-155 518.4 2.4 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nse4-Nse3_bdg PF15412.6 EFA76714.1 - 0.014 15.5 1.0 0.073 13.2 0.0 2.5 3 0 0 3 3 3 0 Binding domain of Nse4/EID3 to Nse3-MAGE SLS PF14611.6 EFA76714.1 - 0.018 14.9 0.1 0.35 10.7 0.1 2.5 2 1 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator Tnp_22_dsRBD PF17490.2 EFA76714.1 - 0.14 12.2 0.0 9.5 6.3 0.0 3.2 3 0 0 3 3 3 0 L1 transposable element dsRBD-like domain Rad1 PF02144.16 EFA76715.1 - 5.5e-48 163.4 1.0 9.7e-48 162.6 1.0 1.3 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Cpn10 PF00166.21 EFA76718.1 - 7.4e-22 77.2 0.0 8.7e-22 77.0 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Mt_ATP-synt_B PF05405.14 EFA76719.1 - 0.1 12.2 3.1 0.08 12.6 0.5 2.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Guanylate_cyc PF00211.20 EFA76719.1 - 0.12 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain TPR_MLP1_2 PF07926.12 EFA76719.1 - 0.34 11.0 0.1 0.34 11.0 0.1 3.1 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein PPR_2 PF13041.6 EFA76720.1 - 1.9e-47 159.3 6.1 5.3e-13 49.0 0.1 8.1 3 3 6 9 9 9 6 PPR repeat family PPR PF01535.20 EFA76720.1 - 2.9e-36 121.2 21.2 1.1e-07 31.6 0.1 9.7 8 1 0 8 8 8 7 PPR repeat PPR_1 PF12854.7 EFA76720.1 - 1.5e-33 114.1 8.9 6.5e-06 25.8 0.0 9.2 9 0 0 9 9 9 6 PPR repeat PPR_3 PF13812.6 EFA76720.1 - 4.3e-32 110.0 6.3 2.7e-05 24.1 0.0 6.6 3 1 3 6 6 6 6 Pentatricopeptide repeat domain PPR_long PF17177.4 EFA76720.1 - 2.1e-19 69.7 0.8 8e-08 31.9 0.1 3.4 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EFA76720.1 - 1.8e-05 24.6 0.5 0.091 12.6 0.0 4.1 3 1 1 4 4 4 2 Mitochondrial ATPase expression Exog_C PF18026.1 EFA76720.1 - 0.11 12.6 0.1 0.84 9.7 0.0 2.7 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Glyco_transf_10 PF00852.19 EFA76721.1 - 4.6e-38 130.7 3.7 5.3e-38 130.5 0.8 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Laminin_G_3 PF13385.6 EFA76721.1 - 3.2e-07 30.6 0.0 5.8e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Hormone_3 PF00159.18 EFA76721.1 - 0.13 12.4 0.4 4 7.6 0.1 2.4 2 0 0 2 2 2 0 Pancreatic hormone peptide MerC PF03203.14 EFA76723.1 - 0.016 15.7 0.0 0.022 15.2 0.0 1.2 1 0 0 1 1 1 0 MerC mercury resistance protein DUF4203 PF13886.6 EFA76723.1 - 0.028 14.1 0.7 0.036 13.7 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4203) Ras PF00071.22 EFA76724.1 - 2.6e-54 183.2 0.0 3e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA76724.1 - 7.1e-20 71.4 0.0 1.1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA76724.1 - 8.6e-09 35.1 0.0 9.6e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA76724.1 - 0.00013 21.5 0.0 0.0054 16.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFA76724.1 - 0.00014 21.4 0.0 0.00094 18.7 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA76724.1 - 0.00014 21.8 0.1 0.37 10.7 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA76724.1 - 0.0002 21.4 0.0 0.00034 20.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PglD_N PF17836.1 EFA76724.1 - 0.081 13.6 0.0 0.15 12.8 0.0 1.5 1 0 0 1 1 1 0 PglD N-terminal domain CbiA PF01656.23 EFA76724.1 - 0.13 12.3 0.2 0.36 10.9 0.2 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EFA76724.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Cnd1 PF12717.7 EFA76726.1 - 0.00033 20.7 1.3 0.035 14.2 0.2 2.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA76726.1 - 0.00086 19.7 0.0 0.0031 17.9 0.0 1.9 1 1 1 2 2 2 1 HEAT repeats TIP120 PF08623.10 EFA76726.1 - 0.0012 18.6 0.8 0.3 10.8 0.0 2.8 2 1 1 3 3 3 2 TATA-binding protein interacting (TIP20) HEAT PF02985.22 EFA76726.1 - 0.0018 18.3 0.0 3.9 8.0 0.0 4.6 5 2 0 5 5 5 1 HEAT repeat STAG PF08514.11 EFA76726.1 - 0.012 15.6 0.5 0.047 13.6 0.5 2.2 1 1 0 1 1 1 0 STAG domain Cnd3 PF12719.7 EFA76727.1 - 0.004 16.4 0.1 0.004 16.4 0.1 3.1 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain PH_5 PF15405.6 EFA76727.1 - 0.02 15.0 1.9 0.02 15.0 1.9 3.2 3 2 0 3 3 3 0 Pleckstrin homology domain CH PF00307.31 EFA76728.1 - 3.4e-15 56.2 0.5 1.8e-14 53.8 0.0 2.5 3 0 0 3 3 3 1 Calponin homology (CH) domain SBF2 PF12335.8 EFA76728.1 - 2e-11 44.0 0.4 2e-11 44.0 0.4 3.7 4 0 0 4 4 4 1 Myotubularin protein zf-RanBP PF00641.18 EFA76728.1 - 0.00082 18.6 6.1 0.00082 18.6 6.1 2.5 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zinc_ribbon_2 PF13240.6 EFA76728.1 - 0.002 17.8 9.8 0.0054 16.4 3.8 2.6 2 0 0 2 2 2 1 zinc-ribbon domain CDC24 PF06395.11 EFA76728.1 - 0.004 17.4 2.3 0.0091 16.2 0.0 2.7 3 0 0 3 3 3 1 CDC24 Calponin CAMSAP_CH PF11971.8 EFA76728.1 - 0.0071 16.2 0.0 0.021 14.6 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain DZR PF12773.7 EFA76728.1 - 0.089 12.8 10.0 0.047 13.7 1.4 2.4 2 0 0 2 2 2 0 Double zinc ribbon UPF0242 PF06785.11 EFA76728.1 - 0.18 11.9 31.8 0.02 15.0 6.4 3.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 EFA76728.1 - 2 8.6 36.6 3.8 7.7 7.2 3.6 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Kelch_6 PF13964.6 EFA76729.1 - 1.4e-14 53.8 2.7 3e-07 30.5 0.1 4.5 5 0 0 5 5 5 2 Kelch motif RecO_N_2 PF13114.6 EFA76729.1 - 0.062 13.0 0.4 11 5.8 0.1 2.8 2 0 0 2 2 2 0 RecO N terminal CorC_HlyC PF03471.17 EFA76730.1 - 0.02 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 Transporter associated domain Ago_N_1 PF18351.1 EFA76730.1 - 0.063 13.7 0.7 0.29 11.6 0.1 2.4 2 0 0 2 2 2 0 Fungal Argonaute N-terminal domain RhoGEF PF00621.20 EFA76731.1 - 0.0032 17.7 1.2 0.58 10.4 0.2 2.1 2 0 0 2 2 2 2 RhoGEF domain MMS1_N PF10433.9 EFA76732.1 - 5e-104 348.7 0.0 9.2e-51 173.0 0.0 2.7 2 1 1 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFA76732.1 - 6e-51 173.7 0.1 2.7e-26 92.7 0.0 4.0 3 2 1 4 4 4 2 CPSF A subunit region URO-D PF01208.17 EFA76733.1 - 9.2e-127 422.9 0.0 1e-126 422.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) GCV_H PF01597.19 EFA76734.1 - 6.6e-07 29.2 0.0 1.2e-05 25.2 0.0 2.0 1 1 0 1 1 1 1 Glycine cleavage H-protein BOP1NT PF08145.12 EFA76735.1 - 2.1e-96 322.9 11.0 2.1e-96 322.9 11.0 2.2 2 0 0 2 2 2 1 BOP1NT (NUC169) domain WD40 PF00400.32 EFA76735.1 - 4.2e-27 93.8 4.7 8e-11 42.3 0.1 6.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA76735.1 - 1e-10 41.8 0.9 9.2e-07 29.1 0.1 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA76735.1 - 1.3e-05 25.2 1.4 0.016 15.1 0.2 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A F5_F8_type_C PF00754.25 EFA76736.1 - 8.4e-12 45.3 1.6 1.1e-11 45.0 1.6 1.1 1 0 0 1 1 1 1 F5/8 type C domain Alpha_kinase PF02816.18 EFA76737.1 - 3e-40 138.3 2.7 3e-40 138.3 2.7 2.4 2 0 0 2 2 2 1 Alpha-kinase family SAM_KSR1 PF13543.6 EFA76737.1 - 0.04 14.1 2.1 0.1 12.8 2.1 1.7 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 Ribosomal_L17 PF01196.19 EFA76737.1 - 0.048 14.6 0.9 0.093 13.6 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L17 VWA_2 PF13519.6 EFA76737.1 - 0.058 14.1 0.0 0.24 12.1 0.0 2.1 1 0 0 1 1 1 0 von Willebrand factor type A domain Dehydrin PF00257.19 EFA76737.1 - 0.074 13.6 1.8 0.64 10.6 0.1 2.3 2 0 0 2 2 2 0 Dehydrin CPSF100_C PF13299.6 EFA76737.1 - 1.6 8.9 4.2 1.6 8.9 0.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal tRNA_Me_trans PF03054.16 EFA76740.1 - 1.9e-109 365.8 0.0 2.2e-109 365.5 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 EFA76740.1 - 1.6e-06 27.4 0.0 1.9e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 NAD synthase ThiI PF02568.14 EFA76740.1 - 4.1e-06 26.5 0.0 4.7e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 EFA76740.1 - 6.2e-05 22.8 0.0 0.0011 18.7 0.0 2.2 1 1 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 EFA76740.1 - 0.00055 19.7 0.0 0.00076 19.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 EFA76740.1 - 0.0039 16.7 0.1 0.02 14.4 0.1 2.1 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC Rbsn PF11464.8 EFA76741.1 - 1.1 9.0 4.4 0.41 10.4 0.6 2.2 2 0 0 2 2 2 0 Rabenosyn Rab binding domain Laminin_G_3 PF13385.6 EFA76742.1 - 3.4e-10 40.3 0.1 1e-09 38.7 0.1 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Atx10homo_assoc PF09759.9 EFA76742.1 - 3.7e-05 23.7 4.3 1.7 8.7 0.0 6.1 6 0 0 6 6 6 1 Spinocerebellar ataxia type 10 protein domain DUF4704 PF15787.5 EFA76742.1 - 0.0064 15.8 19.0 0.42 9.8 0.4 6.3 5 1 0 6 6 6 3 Domain of unknown function (DUF4704) Dicty_spore_N PF04562.12 EFA76744.1 - 1.2e-13 51.8 27.4 1.8e-13 51.2 27.4 1.3 1 0 0 1 1 1 1 Dictyostelium spore coat protein, N terminus PHD PF00628.29 EFA76745.1 - 5.6e-26 90.2 46.3 1.1e-11 44.4 7.1 4.2 2 1 2 4 4 4 3 PHD-finger HMG_box PF00505.19 EFA76745.1 - 1.6e-18 66.8 3.1 1.6e-18 66.8 3.1 3.0 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFA76745.1 - 1.4e-12 48.0 4.4 1.6e-10 41.4 2.0 3.0 2 0 0 2 2 2 1 HMG-box domain DUF615 PF04751.14 EFA76745.1 - 0.002 18.1 1.2 0.002 18.1 1.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF615) C1_1 PF00130.22 EFA76745.1 - 0.0086 15.9 4.4 0.0086 15.9 4.4 6.4 2 2 5 7 7 7 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 EFA76745.1 - 0.012 15.2 5.8 0.012 15.2 5.8 5.7 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain HMG_box_5 PF14887.6 EFA76745.1 - 0.12 12.3 4.3 0.066 13.2 1.5 2.1 2 1 0 2 2 2 0 HMG (high mobility group) box 5 Zf_RING PF16744.5 EFA76745.1 - 0.66 10.1 46.7 0.18 11.9 7.6 5.3 2 2 2 4 4 4 0 KIAA1045 RING finger FlxA PF14282.6 EFA76745.1 - 3.2 7.8 47.3 0.15 12.1 7.7 3.2 2 0 0 2 2 2 0 FlxA-like protein Metallophos PF00149.28 EFA76746.1 - 7e-08 33.2 0.8 7e-08 33.2 0.8 2.0 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase WHIM1 PF15612.6 EFA76746.1 - 3.7e-06 26.3 0.0 7.6e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 CENP-B_dimeris PF09026.10 EFA76746.1 - 0.0055 17.1 9.2 0.0055 17.1 9.2 3.4 1 1 1 3 3 3 1 Centromere protein B dimerisation domain SDA1 PF05285.12 EFA76746.1 - 0.16 11.4 26.1 0.32 10.4 26.1 1.5 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFA76746.1 - 0.2 9.8 30.5 0.31 9.2 30.5 1.3 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 EFA76746.1 - 0.28 11.4 31.1 0.016 15.5 25.5 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 WAC_Acf1_DNA_bd PF10537.9 EFA76747.1 - 2e-28 98.9 0.9 2e-28 98.9 0.9 1.9 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal DUF5097 PF17020.5 EFA76747.1 - 0.01 16.1 2.2 0.014 15.7 0.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5097) DUF572 PF04502.13 EFA76747.1 - 0.015 15.0 28.8 0.019 14.6 28.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) TAF4 PF05236.14 EFA76747.1 - 0.039 13.7 21.1 0.062 13.0 21.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family SR-25 PF10500.9 EFA76747.1 - 0.87 9.1 71.5 0.094 12.3 30.3 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Mitofilin PF09731.9 EFA76747.1 - 0.97 8.2 26.7 1.2 7.9 26.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Utp14 PF04615.13 EFA76747.1 - 1.2 7.7 39.0 1.5 7.3 39.0 1.1 1 0 0 1 1 1 0 Utp14 protein CDC45 PF02724.14 EFA76747.1 - 4.1 5.6 33.5 5.9 5.1 33.5 1.3 1 0 0 1 1 1 0 CDC45-like protein ILEI PF15711.5 EFA76749.1 - 0.0074 16.7 0.1 0.015 15.8 0.1 1.5 1 0 0 1 1 1 1 Interleukin-like EMT inducer Synaphin PF05835.12 EFA76749.1 - 0.057 13.7 1.2 0.12 12.6 1.2 1.6 1 0 0 1 1 1 0 Synaphin protein Sec3_C PF09763.9 EFA76750.1 - 2e-66 224.8 4.4 1e-54 186.1 0.0 2.0 1 1 1 2 2 2 2 Exocyst complex component Sec3 PRR18 PF15671.5 EFA76750.1 - 0.0077 16.2 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 Proline-rich protein family 18 PriX PF18689.1 EFA76750.1 - 0.037 14.4 0.2 0.22 11.9 0.1 2.3 2 0 0 2 2 2 0 Primase X Gemini_AL1_M PF08283.11 EFA76750.1 - 0.064 13.4 0.2 0.16 12.1 0.2 1.7 1 0 0 1 1 1 0 Geminivirus rep protein central domain La PF05383.17 EFA76751.1 - 5.8e-16 58.3 0.5 5.8e-16 58.3 0.5 2.5 3 0 0 3 3 3 1 La domain RRM_1 PF00076.22 EFA76751.1 - 2.1e-15 56.3 0.7 1.3e-14 53.8 0.1 2.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFA76751.1 - 0.00013 22.0 0.2 0.00013 22.0 0.2 3.7 2 1 1 3 3 3 1 RNA binding motif DUF4228 PF14009.6 EFA76751.1 - 0.62 10.4 6.9 0.56 10.6 3.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Vps39_2 PF10367.9 EFA76752.1 - 1.1e-28 99.8 0.0 4.6e-28 97.9 0.0 2.2 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EFA76752.1 - 6.3e-20 71.9 0.2 1.3e-19 70.9 0.2 1.4 1 0 0 1 1 1 1 CNH domain Vps39_1 PF10366.9 EFA76752.1 - 1.2e-19 70.6 7.4 7.6e-18 64.8 1.8 5.0 4 2 1 5 5 5 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 EFA76752.1 - 2.8e-14 53.2 9.3 7.7e-10 38.8 1.2 3.7 4 1 0 4 4 4 2 Region in Clathrin and VPS DUF2175 PF09943.9 EFA76752.1 - 0.0076 16.5 1.1 0.023 15.0 0.1 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) TPR_1 PF00515.28 EFA76752.1 - 2.3 8.2 4.5 17 5.4 0.7 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.6 EFA76754.1 - 8.8e-10 37.9 2.7 0.0002 21.1 0.1 3.1 2 0 0 2 2 2 2 Leucine Rich repeat LRR_1 PF00560.33 EFA76754.1 - 4.4 8.2 0.0 4.4 8.2 0.0 3.7 5 1 0 5 5 5 0 Leucine Rich Repeat Cluap1 PF10234.9 EFA76755.1 - 0.099 12.0 0.5 0.13 11.6 0.5 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 SOG2 PF10428.9 EFA76755.1 - 6 6.0 14.4 9.6 5.3 14.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein ECH_2 PF16113.5 EFA76756.1 - 2.3e-85 287.1 0.0 9.7e-85 285.0 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFA76756.1 - 2.7e-15 56.4 0.0 8e-15 54.8 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Latarcin PF10279.9 EFA76756.1 - 0.084 13.3 0.3 0.25 11.8 0.3 1.8 1 0 0 1 1 1 0 Latarcin precursor Tail_tube PF10618.9 EFA76756.1 - 0.096 12.6 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Phage tail tube protein DUF974 PF06159.13 EFA76757.1 - 3.4e-52 177.7 1.5 2e-51 175.2 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF974) SUIM_assoc PF16619.5 EFA76757.1 - 0.00091 19.2 0.2 0.002 18.1 0.2 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 PPR_2 PF13041.6 EFA76758.1 - 8e-06 26.0 0.5 0.034 14.3 0.2 2.8 2 0 0 2 2 2 2 PPR repeat family Ank_2 PF12796.7 EFA76759.1 - 0.0033 18.0 0.0 1.8 9.2 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) V-set_CD47 PF08204.11 EFA76759.1 - 0.018 15.0 1.0 0.029 14.4 1.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Ank_3 PF13606.6 EFA76759.1 - 0.035 14.6 0.1 3.8 8.4 0.1 2.9 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EFA76759.1 - 0.073 13.4 0.0 0.92 9.9 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) fn3 PF00041.21 EFA76760.1 - 5.3e-52 174.1 74.8 0.00023 21.4 0.1 18.6 17 1 0 17 17 17 15 Fibronectin type III domain DUF2369 PF10179.9 EFA76760.1 - 5.4e-15 55.6 63.5 0.0014 19.0 0.8 13.2 13 1 0 14 14 14 7 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 EFA76760.1 - 1.2e-05 25.8 103.0 1.3 9.6 0.6 17.8 11 5 1 12 12 11 6 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.13 EFA76760.1 - 4.1e-05 23.8 9.4 0.00013 22.3 9.4 2.0 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA76760.1 - 0.0014 18.9 4.5 0.0058 16.9 4.5 2.2 1 0 0 1 1 1 1 EGF-like domain HNOB PF07700.15 EFA76760.1 - 0.022 14.7 2.3 9.7 6.1 0.0 4.8 5 0 0 5 5 5 0 Haem-NO-binding hEGF PF12661.7 EFA76760.1 - 0.094 13.4 4.4 0.8 10.4 4.4 2.9 1 0 0 1 1 1 0 Human growth factor-like EGF Mating_C PF12737.7 EFA76760.1 - 0.26 10.5 14.2 2 7.6 0.3 4.7 4 1 0 4 4 4 0 C-terminal domain of homeodomain 1 EB PF01683.18 EFA76760.1 - 0.37 11.1 8.0 0.045 14.1 1.7 2.9 2 0 0 2 2 1 0 EB module I-EGF_1 PF18372.1 EFA76760.1 - 0.4 10.8 7.9 1.1 9.4 7.9 1.8 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 DUF5581 PF17744.1 EFA76760.1 - 0.55 9.5 9.1 5.6 6.2 0.2 4.0 4 0 0 4 4 4 0 Family of unknown function (DUF5581) 2Fe-2S_thioredx PF01257.19 EFA76760.1 - 1.5 8.6 6.3 39 4.1 0.1 3.6 3 0 0 3 3 3 0 Thioredoxin-like [2Fe-2S] ferredoxin DUF3430 PF11912.8 EFA76761.1 - 0.00024 21.2 4.2 0.00029 21.0 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) Ank_2 PF12796.7 EFA76762.1 - 7.2e-12 45.7 3.5 0.00034 21.1 0.3 4.4 2 2 3 5 5 5 3 Ankyrin repeats (3 copies) VPS9 PF02204.18 EFA76762.1 - 7.8e-09 35.7 0.1 2.3e-08 34.2 0.1 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_4 PF13637.6 EFA76762.1 - 1.7e-08 34.8 1.2 0.0092 16.5 0.0 4.5 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA76762.1 - 1.3e-05 25.4 2.9 3.2 8.4 0.0 5.5 5 1 0 5 5 5 1 Ankyrin repeat Ank_3 PF13606.6 EFA76762.1 - 5.1e-05 23.3 3.6 4 8.3 0.0 5.9 6 0 0 6 6 6 1 Ankyrin repeat Ank_5 PF13857.6 EFA76762.1 - 0.0012 19.1 0.7 5.1 7.5 0.1 4.5 2 2 3 5 5 5 2 Ankyrin repeats (many copies) Hamartin PF04388.12 EFA76762.1 - 0.51 8.9 55.0 0.3 9.7 23.5 2.3 2 0 0 2 2 2 0 Hamartin protein RelB_leu_zip PF16180.5 EFA76763.1 - 0.003 17.5 0.3 0.0044 17.0 0.3 1.2 1 0 0 1 1 1 1 RelB leucine zipper Amidinotransf PF02274.17 EFA76764.1 - 1.4e-16 60.5 0.1 6e-16 58.5 0.0 1.8 1 1 1 2 2 2 1 Amidinotransferase Nuf2 PF03800.14 EFA76764.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Nuf2 family Ribosomal_S16 PF00886.19 EFA76766.1 - 0.019 15.0 0.0 0.046 13.8 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein S16 PYRIN PF02758.16 EFA76766.1 - 0.033 14.3 0.1 0.36 11.0 0.2 2.1 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Coiled PF05710.12 EFA76767.1 - 0.021 15.7 1.9 0.024 15.5 1.9 1.2 1 0 0 1 1 1 0 Coiled coil Abhydrolase_1 PF00561.20 EFA76769.1 - 1.2e-13 51.3 0.0 3.7e-13 49.7 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA76769.1 - 3.7e-10 39.5 0.0 8.2e-10 38.4 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EFA76769.1 - 0.0023 17.3 0.1 0.018 14.4 0.0 2.2 1 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Cutinase PF01083.22 EFA76769.1 - 0.028 14.4 0.1 0.06 13.3 0.1 1.6 1 0 0 1 1 1 0 Cutinase ABC_membrane PF00664.23 EFA76770.1 - 2e-68 231.0 41.4 1.7e-39 136.1 19.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA76770.1 - 7.2e-50 169.1 0.1 5.4e-30 104.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA76770.1 - 2.9e-09 36.7 2.8 0.11 11.9 0.0 4.5 2 2 2 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA76770.1 - 4.9e-07 29.4 0.3 0.016 14.9 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA76770.1 - 1.2e-06 28.8 0.1 0.011 16.0 0.0 3.4 3 1 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EFA76770.1 - 3e-05 24.1 0.5 0.14 12.3 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA76770.1 - 6e-05 23.0 0.1 0.026 14.4 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase TrwB_AAD_bind PF10412.9 EFA76770.1 - 0.00041 19.4 0.1 0.71 8.7 0.0 2.4 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.6 EFA76770.1 - 0.00059 20.3 0.8 2 8.8 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 EFA76770.1 - 0.0011 19.1 3.1 0.23 11.5 0.1 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_7 PF12775.7 EFA76770.1 - 0.0045 16.5 0.4 1.4 8.4 0.2 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 EFA76770.1 - 0.0051 17.3 6.7 2.1 8.8 0.0 3.3 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EFA76770.1 - 0.0084 15.3 1.0 1.3 8.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 EFA76770.1 - 0.011 15.1 0.6 0.7 9.2 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 EFA76770.1 - 0.017 14.9 0.2 11 5.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 EFA76770.1 - 0.034 14.0 2.9 6.6 6.4 0.1 3.6 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EFA76770.1 - 0.052 13.8 0.0 25 5.2 0.0 3.4 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 EFA76770.1 - 0.065 12.5 0.7 8.9 5.5 0.2 2.5 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 EFA76770.1 - 0.1 12.4 3.2 0.38 10.5 0.4 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EFA76770.1 - 0.1 12.3 1.4 0.33 10.7 0.2 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EFA76770.1 - 0.13 12.8 0.7 16 6.1 0.0 3.1 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 EFA76770.1 - 0.13 12.4 0.2 0.86 9.8 0.2 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EFA76770.1 - 0.16 10.9 0.1 19 4.1 0.0 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EFA76770.1 - 0.24 11.8 2.0 9.6 6.6 0.1 3.6 4 0 0 4 4 4 0 RNA helicase cobW PF02492.19 EFA76770.1 - 0.31 10.6 2.7 0.95 9.0 0.6 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 EFA76770.1 - 0.36 11.0 1.9 22 5.3 0.0 3.2 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFA76770.1 - 0.68 10.0 4.7 5.1 7.1 0.7 2.9 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.6 EFA76770.1 - 5.3 6.7 8.3 22 4.7 0.2 3.4 3 1 0 3 3 3 0 AAA domain Clathrin PF00637.20 EFA76771.1 - 7.9e-198 648.3 55.9 6.4e-32 110.4 0.6 8.9 10 0 0 10 10 10 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EFA76771.1 - 6.9e-36 120.8 6.0 4e-06 26.9 0.0 6.7 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin_H_link PF13838.6 EFA76771.1 - 8.6e-29 99.3 0.6 8.6e-29 99.3 0.6 3.7 4 0 0 4 4 4 1 Clathrin-H-link Clathrin-link PF09268.10 EFA76771.1 - 2.8e-12 45.7 1.2 9.9e-12 44.0 1.2 2.0 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_2 PF07719.17 EFA76771.1 - 3.5e-05 23.6 8.5 4.9 7.5 0.0 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EFA76771.1 - 6.3e-05 22.2 4.4 0.076 12.0 0.1 4.1 4 0 0 4 4 4 2 Coatomer WD associated region TPR_14 PF13428.6 EFA76771.1 - 0.00021 21.9 2.7 68 4.7 0.1 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA76771.1 - 0.00066 19.4 6.9 0.69 9.8 0.1 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76771.1 - 0.00085 19.2 6.1 3.4 7.9 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76771.1 - 0.0019 18.3 6.2 12 6.4 0.1 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76771.1 - 0.018 15.3 1.8 42 4.5 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat HCNGP PF07818.13 EFA76771.1 - 0.21 12.2 2.4 0.26 12.0 0.1 2.3 2 0 0 2 2 2 0 HCNGP-like protein Tom37 PF10568.9 EFA76771.1 - 0.57 10.5 5.4 0.36 11.1 0.6 3.0 3 0 0 3 3 3 0 Outer mitochondrial membrane transport complex protein TPR_11 PF13414.6 EFA76771.1 - 1.8 8.3 6.6 29 4.4 0.5 4.7 5 0 0 5 5 5 0 TPR repeat Tmpp129 PF10272.9 EFA76772.1 - 2 7.6 8.8 0.67 9.2 3.6 2.3 3 0 0 3 3 3 0 Putative transmembrane protein precursor E1-E2_ATPase PF00122.20 EFA76773.1 - 1.6e-47 161.4 1.4 1.6e-47 161.4 1.4 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFA76773.1 - 7.8e-42 143.0 2.5 7.8e-42 143.0 2.5 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EFA76773.1 - 4.3e-23 81.2 0.0 1e-22 80.0 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA76773.1 - 8.5e-21 75.2 0.0 1.5e-09 38.5 0.0 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA76773.1 - 1.6e-20 72.6 0.0 3.2e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA76773.1 - 0.0007 19.4 0.3 0.0007 19.4 0.3 3.8 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA76773.1 - 0.096 13.1 0.0 0.91 9.9 0.0 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Peptidase_S28 PF05577.12 EFA76774.1 - 9.7e-77 258.6 5.6 2.7e-76 257.1 5.6 1.7 1 1 0 1 1 1 1 Serine carboxypeptidase S28 EB PF01683.18 EFA76775.1 - 0.0013 18.9 3.9 0.0029 17.9 2.3 2.3 2 0 0 2 2 2 1 EB module I-EGF_1 PF18372.1 EFA76775.1 - 0.0068 16.5 7.0 0.016 15.3 7.0 1.6 1 0 0 1 1 1 1 Integrin beta epidermal growth factor like domain 1 SieB PF14163.6 EFA76775.1 - 0.0091 15.5 0.1 0.022 14.2 0.1 1.7 1 0 0 1 1 1 1 Super-infection exclusion protein B EGF_2 PF07974.13 EFA76775.1 - 0.013 15.8 16.9 0.034 14.5 16.9 1.7 1 0 0 1 1 1 0 EGF-like domain LapA_dom PF06305.11 EFA76775.1 - 0.077 12.8 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain hEGF PF12661.7 EFA76775.1 - 0.33 11.7 9.1 1.3 9.8 9.1 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 EFA76775.1 - 6.2 7.2 11.8 24 5.3 11.8 2.1 1 0 0 1 1 1 0 EGF-like domain DSPc PF00782.20 EFA76776.1 - 1.4e-28 99.4 1.1 1.6e-28 99.2 0.1 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA76776.1 - 0.0025 17.4 0.2 0.0058 16.2 0.1 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase RAG1_imp_bd PF12560.8 EFA76776.1 - 0.045 13.3 3.2 0.074 12.6 3.2 1.3 1 0 0 1 1 1 0 RAG1 importin binding Y_phosphatase3 PF13350.6 EFA76776.1 - 0.088 12.8 0.9 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFA76776.1 - 0.13 12.3 6.9 0.34 11.0 0.0 2.5 2 0 0 2 2 2 0 Inositol hexakisphosphate zf-DNA_Pol PF08996.10 EFA76776.1 - 1 9.1 7.3 0.19 11.5 0.7 2.2 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger DUF35_N PF12172.8 EFA76776.1 - 2.3 8.2 7.0 0.41 10.6 0.4 2.7 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) TBCA PF02970.16 EFA76776.1 - 8.3 6.8 19.5 15 6.0 19.5 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A WD40 PF00400.32 EFA76777.1 - 7.4e-05 23.5 7.2 0.057 14.3 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Macoilin PF09726.9 EFA76777.1 - 0.069 11.7 15.1 0.084 11.4 15.1 1.1 1 0 0 1 1 1 0 Macoilin family DUF4337 PF14235.6 EFA76777.1 - 0.1 12.7 4.3 1.9 8.6 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Xan_ur_permease PF00860.20 EFA76778.1 - 2.2e-78 263.7 43.4 2.2e-78 263.7 43.4 1.5 2 0 0 2 2 2 1 Permease family RCC1 PF00415.18 EFA76778.1 - 1.1e-66 221.3 15.1 6.7e-15 55.5 0.1 7.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA76778.1 - 4.3e-40 134.7 27.5 5.2e-07 29.3 0.1 9.3 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat RasGAP PF00616.19 EFA76778.1 - 1.5e-18 67.3 12.5 1.7e-09 37.7 0.0 3.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase RhoGEF PF00621.20 EFA76778.1 - 5.2e-13 49.6 1.0 5.2e-13 49.6 1.0 3.2 3 1 1 4 4 4 1 RhoGEF domain BAR_3 PF16746.5 EFA76778.1 - 5.8e-09 36.0 11.2 5.8e-09 36.0 11.2 2.2 2 0 0 2 2 2 1 BAR domain of APPL family BAR PF03114.18 EFA76778.1 - 1.8e-05 24.5 8.1 1.8e-05 24.5 8.1 2.3 2 0 0 2 2 2 1 BAR domain CAF-1_p150 PF11600.8 EFA76778.1 - 1.7 8.3 44.7 4.3 7.0 44.7 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AAA_23 PF13476.6 EFA76778.1 - 9.3 6.7 30.3 0.021 15.3 11.0 3.6 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 EFA76779.1 - 7.2e-39 133.4 0.3 1.2e-38 132.6 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA76779.1 - 4.1e-30 104.4 1.5 1.2e-26 93.2 0.3 3.1 2 1 1 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EFA76779.1 - 1.8e-06 28.0 0.0 4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFA76779.1 - 0.00064 19.1 0.0 0.0015 17.9 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Nop14 PF04147.12 EFA76780.1 - 0.51 8.5 14.6 0.71 8.0 14.6 1.1 1 0 0 1 1 1 0 Nop14-like family Lin-8 PF03353.15 EFA76780.1 - 0.6 9.6 13.8 0.88 9.1 13.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Glyco_hydro_18 PF00704.28 EFA76781.1 - 3.1e-21 76.4 1.9 7.4e-21 75.2 0.9 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CCDC85 PF10226.9 EFA76782.1 - 0.16 11.6 0.0 0.16 11.6 0.0 2.5 3 0 0 3 3 3 0 CCDC85 family Y_phosphatase PF00102.27 EFA76783.1 - 1.5e-21 77.1 1.3 1.5e-21 77.1 1.3 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase OEP PF02321.18 EFA76784.1 - 4 7.2 7.5 4.1 7.2 1.7 2.7 2 1 0 2 2 2 0 Outer membrane efflux protein Response_reg PF00072.24 EFA76785.1 - 6.7e-32 110.0 0.7 2.4e-22 79.2 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 EFA76785.1 - 2.7e-20 72.9 0.0 6e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SUIM_assoc PF16619.5 EFA76785.1 - 0.012 15.7 0.0 0.012 15.7 0.0 6.4 4 3 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 EFA76785.1 - 0.03 13.1 0.0 0.03 13.1 0.0 4.4 3 1 1 4 4 4 0 Presenilin Rnf-Nqr PF02508.14 EFA76785.1 - 0.036 14.0 2.6 0.098 12.6 2.6 1.7 1 0 0 1 1 1 0 Rnf-Nqr subunit, membrane protein Ank_2 PF12796.7 EFA76786.1 - 5.8e-18 65.3 0.0 1.5e-06 28.7 0.0 4.6 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76786.1 - 2.7e-15 56.5 0.2 0.0001 22.8 0.0 5.6 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76786.1 - 9.1e-11 41.0 0.7 0.65 10.7 0.0 7.7 8 1 1 9 9 9 3 Ankyrin repeat Ank_5 PF13857.6 EFA76786.1 - 1.2e-10 41.4 0.2 1.4 9.3 0.0 7.4 4 2 4 8 8 8 3 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA76786.1 - 0.00035 20.5 12.8 0.16 12.0 1.3 5.8 2 2 4 6 6 6 3 Domain of unknown function (DUF3447) RNA_pol_Rpc34 PF05158.12 EFA76787.1 - 1e-56 192.7 3.3 8.1e-37 127.4 1.8 2.5 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit TrmB PF01978.19 EFA76787.1 - 2.1e-05 24.3 0.4 0.014 15.2 0.1 3.3 3 0 0 3 3 3 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 EFA76787.1 - 0.0011 19.0 0.1 0.0037 17.4 0.1 2.0 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC RPA_C PF08784.11 EFA76787.1 - 0.0033 18.1 2.2 0.16 12.6 0.3 3.1 2 2 1 3 3 3 1 Replication protein A C terminal DUF2250 PF10007.9 EFA76787.1 - 0.013 15.6 1.3 0.56 10.3 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) TFIIE_beta PF02186.15 EFA76787.1 - 0.024 14.9 3.1 0.46 10.8 0.0 3.2 2 1 0 3 3 3 0 TFIIE beta subunit core domain Rrf2 PF02082.20 EFA76787.1 - 0.035 14.5 0.5 0.29 11.5 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator Cdc6_C PF09079.11 EFA76787.1 - 0.077 13.0 0.3 3.2 7.8 0.0 3.2 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain DsrD PF08679.11 EFA76787.1 - 0.084 13.1 0.2 8.9 6.7 0.0 2.6 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) MarR_2 PF12802.7 EFA76787.1 - 0.085 12.8 0.1 1.2 9.1 0.0 2.4 3 0 0 3 3 3 0 MarR family MarR PF01047.22 EFA76787.1 - 0.091 12.7 1.8 0.91 9.5 0.2 3.0 4 0 0 4 4 4 0 MarR family HTH_27 PF13463.6 EFA76787.1 - 0.11 13.0 0.5 1 9.9 0.1 2.5 2 0 0 2 2 2 0 Winged helix DNA-binding domain DED PF01335.21 EFA76787.1 - 0.13 12.6 0.5 4.4 7.7 0.1 2.6 2 0 0 2 2 2 0 Death effector domain Ctr PF04145.15 EFA76788.1 - 1.1e-25 91.0 5.8 1.6e-25 90.5 5.8 1.2 1 0 0 1 1 1 1 Ctr copper transporter family TrbL PF04610.14 EFA76788.1 - 0.0044 16.8 5.1 0.66 9.7 0.2 2.2 2 0 0 2 2 2 2 TrbL/VirB6 plasmid conjugal transfer protein RRM_1 PF00076.22 EFA76789.1 - 4.6e-10 39.2 0.1 9.8e-10 38.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EFA76789.1 - 1e-06 28.6 1.9 3.2e-06 27.0 1.9 1.9 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EFA76789.1 - 1.5e-05 24.8 3.0 1.5e-05 24.8 3.0 2.3 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFA76789.1 - 0.00064 20.4 0.0 0.00064 20.4 0.0 2.6 2 0 0 2 2 1 1 Torus domain zf-CCCH_4 PF18044.1 EFA76789.1 - 0.0037 17.0 2.9 0.013 15.3 2.9 2.0 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EFA76789.1 - 0.015 15.5 0.2 0.015 15.5 0.2 2.3 3 0 0 3 3 3 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EFA76789.1 - 0.042 14.3 1.5 0.042 14.3 1.5 3.1 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger NPR3 PF03666.13 EFA76789.1 - 0.11 11.2 7.9 0.17 10.6 7.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Utp14 PF04615.13 EFA76789.1 - 0.3 9.6 8.4 0.4 9.2 8.4 1.1 1 0 0 1 1 1 0 Utp14 protein DUF3535 PF12054.8 EFA76789.1 - 0.57 9.4 4.1 0.96 8.6 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) Menin PF05053.13 EFA76789.1 - 0.99 7.7 9.4 1.4 7.2 9.4 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 EFA76789.1 - 1.1 7.9 10.5 1.6 7.4 10.5 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 EFA76789.1 - 2.1 7.1 3.4 2.9 6.6 3.4 1.1 1 0 0 1 1 1 0 HCO3- transporter family Pox_Ag35 PF03286.14 EFA76789.1 - 2.3 8.0 9.5 3.8 7.3 9.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein ALMT PF11744.8 EFA76789.1 - 6.5 5.5 7.1 9.3 5.0 7.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 EFA76789.1 - 7.6 5.6 6.5 11 5.2 6.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NUDIX PF00293.28 EFA76790.1 - 1.1e-19 70.7 0.3 2.1e-19 69.9 0.3 1.5 1 0 0 1 1 1 1 NUDIX domain DUF2268 PF10026.9 EFA76790.1 - 0.057 13.0 0.4 0.14 11.7 0.4 1.6 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) DUF963 PF06131.11 EFA76791.1 - 0.026 14.0 3.1 0.038 13.4 3.1 1.3 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Dickkopf_N PF04706.12 EFA76795.1 - 0.037 14.5 6.9 0.037 14.5 6.9 6.4 4 3 3 7 7 7 0 Dickkopf N-terminal cysteine-rich region AMP-binding PF00501.28 EFA76796.1 - 4.3e-101 338.6 0.0 5.4e-101 338.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA76796.1 - 3.6e-15 56.7 0.0 4e-14 53.4 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain NopRA1 PF16201.5 EFA76797.1 - 3.9e-25 88.6 7.6 6.6e-25 87.9 0.6 3.9 2 1 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 DUF668 PF05003.12 EFA76797.1 - 0.03 14.8 2.1 0.2 12.1 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF668) Dimer_Tnp_hAT PF05699.14 EFA76798.1 - 2e-10 40.3 0.7 7.7e-10 38.4 0.3 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region TPK_catalytic PF04263.16 EFA76799.1 - 1.8e-28 99.0 0.0 2.7e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EFA76799.1 - 5e-16 58.2 0.2 8.7e-16 57.4 0.2 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Acetyltransf_1 PF00583.25 EFA76800.1 - 6.7e-07 29.5 0.0 0.00055 20.2 0.0 3.1 3 0 0 3 3 3 2 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 EFA76800.1 - 0.00016 21.8 0.0 0.02 15.0 0.0 2.6 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_7 PF13508.7 EFA76800.1 - 0.00016 22.0 0.0 0.00074 19.9 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA76800.1 - 0.00023 21.1 0.0 0.0038 17.1 0.0 2.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain NUDIX PF00293.28 EFA76801.1 - 3.4e-10 40.1 0.0 8.6e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain RhoGAP PF00620.27 EFA76802.1 - 3e-31 108.3 0.0 3e-31 108.3 0.0 1.9 2 0 0 2 2 1 1 RhoGAP domain Tim54 PF11711.8 EFA76802.1 - 0.0013 17.6 8.6 0.0033 16.3 8.6 1.6 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 CCDC71L PF15374.6 EFA76802.1 - 0.025 13.9 14.1 0.036 13.3 14.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L TFIIF_alpha PF05793.12 EFA76802.1 - 0.11 11.1 26.6 0.18 10.3 26.6 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GAGA_bind PF06217.12 EFA76802.1 - 0.23 11.7 13.4 0.43 10.8 13.4 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family NARP1 PF12569.8 EFA76802.1 - 0.34 9.8 17.7 0.49 9.2 17.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM76 PF16046.5 EFA76802.1 - 1 8.7 20.4 0.0097 15.3 12.1 1.7 2 0 0 2 2 2 0 FAM76 protein Connexin PF00029.19 EFA76802.1 - 1.1 9.0 11.2 2 8.1 11.2 1.4 1 0 0 1 1 1 0 Connexin DUF2828 PF11443.8 EFA76802.1 - 1.5 6.9 15.3 2.2 6.3 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RPN2_C PF18004.1 EFA76802.1 - 1.5 8.7 21.3 2.9 7.8 21.3 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4718 PF15842.5 EFA76802.1 - 1.5 8.6 8.2 3 7.6 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF755 PF05501.11 EFA76802.1 - 1.8 8.8 35.1 0.057 13.7 28.2 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF755) DUF1168 PF06658.12 EFA76802.1 - 2.8 7.8 34.0 6.7 6.5 34.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) LicD PF04991.13 EFA76802.1 - 3.3 7.8 12.6 5.2 7.1 12.6 1.3 1 0 0 1 1 1 0 LicD family Vfa1 PF08432.10 EFA76802.1 - 3.4 8.0 28.1 0.19 12.1 22.7 1.6 2 0 0 2 2 1 0 AAA-ATPase Vps4-associated protein 1 DUF789 PF05623.12 EFA76802.1 - 3.6 7.2 10.6 7 6.2 10.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) CDC45 PF02724.14 EFA76802.1 - 5.6 5.1 19.2 8.6 4.5 19.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Rtf2 PF04641.12 EFA76802.1 - 5.9 6.2 29.6 0.064 12.6 21.9 1.5 2 0 0 2 2 2 0 Rtf2 RING-finger SID-1_RNA_chan PF13965.6 EFA76802.1 - 6.5 5.0 7.0 10 4.4 7.0 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Otopetrin PF03189.13 EFA76802.1 - 6.7 5.4 5.8 11 4.7 5.8 1.2 1 0 0 1 1 1 0 Otopetrin CLN3 PF02487.17 EFA76802.1 - 7.6 5.5 8.2 15 4.5 8.2 1.4 1 0 0 1 1 1 0 CLN3 protein Kin17_mid PF10357.9 EFA76803.1 - 4.5e-47 159.1 1.0 4.5e-47 159.1 1.0 2.4 2 1 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 EFA76803.1 - 3.1e-24 84.8 1.1 1.2e-22 79.8 2.1 2.4 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain zf-C2H2_jaz PF12171.8 EFA76803.1 - 0.0042 17.3 5.6 0.01 16.1 5.6 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding KOW PF00467.29 EFA76803.1 - 0.0068 16.3 0.0 0.023 14.6 0.0 1.8 2 0 0 2 2 2 1 KOW motif DivIVA PF05103.13 EFA76803.1 - 0.018 15.1 5.7 0.018 15.1 5.7 2.6 1 1 1 2 2 2 0 DivIVA protein zf-met PF12874.7 EFA76803.1 - 0.025 15.0 6.3 0.071 13.5 6.3 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFA76803.1 - 0.052 13.9 2.5 0.16 12.3 0.7 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) FNIP PF05725.12 EFA76804.1 - 5.5e-29 100.1 28.0 8.8e-08 32.2 3.0 7.5 5 1 3 8 8 8 6 FNIP Repeat F-box_5 PF18511.1 EFA76804.1 - 0.0017 17.9 0.1 0.0033 17.0 0.1 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 EFA76804.1 - 0.0031 17.4 0.4 0.0069 16.2 0.4 1.6 1 0 0 1 1 1 1 F-box domain Inp1 PF12634.7 EFA76804.1 - 0.067 13.2 0.0 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Inheritance of peroxisomes protein 1 Ependymin PF00811.18 EFA76805.1 - 0.0036 17.5 0.7 0.0095 16.2 0.3 1.8 2 0 0 2 2 2 1 Ependymin LPMO_10 PF03067.15 EFA76806.1 - 0.00015 22.4 0.1 0.0002 22.1 0.1 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading UPRTase PF14681.6 EFA76807.1 - 5.7e-65 218.6 0.0 8.5e-65 218.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EFA76807.1 - 2.1e-41 141.9 7.5 2.4e-38 131.9 1.1 2.2 1 1 1 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EFA76807.1 - 0.0024 18.4 2.7 0.19 12.3 2.5 3.0 2 1 0 2 2 2 1 AAA domain Pribosyltran PF00156.27 EFA76807.1 - 0.0037 16.8 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain AAA_17 PF13207.6 EFA76807.1 - 0.0071 16.8 0.9 1 9.8 0.3 2.4 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 EFA76807.1 - 0.075 12.7 0.5 11 5.7 0.1 2.3 2 0 0 2 2 2 0 Cytidylate kinase CoaE PF01121.20 EFA76807.1 - 0.077 12.7 1.7 2.4 7.8 0.5 2.2 1 1 0 2 2 2 0 Dephospho-CoA kinase Zeta_toxin PF06414.12 EFA76807.1 - 0.16 11.3 0.0 0.37 10.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin PhoLip_ATPase_C PF16212.5 EFA76808.1 - 7.6e-37 127.4 4.5 1.7e-36 126.3 4.5 1.5 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA76808.1 - 3.5e-23 81.1 0.7 3.5e-23 81.1 0.7 2.9 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFA76808.1 - 1.2e-14 55.1 0.1 2.7e-08 34.4 0.0 3.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA76808.1 - 7.4e-12 45.2 0.0 3.9e-11 42.9 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFA76808.1 - 5.1e-07 29.4 0.1 9.9e-07 28.5 0.1 1.4 1 0 0 1 1 1 1 E1-E2 ATPase EF-hand_8 PF13833.6 EFA76808.1 - 0.014 15.2 0.5 0.049 13.5 0.5 2.0 2 0 0 2 2 2 0 EF-hand domain pair RSN1_7TM PF02714.15 EFA76810.1 - 7.4e-68 228.8 25.3 7.4e-68 228.8 25.3 2.3 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFA76810.1 - 2.3e-31 108.6 5.8 2.3e-31 108.6 5.8 3.9 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFA76810.1 - 5.8e-22 78.8 1.8 1e-20 74.7 1.8 2.2 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PIG-P PF08510.12 EFA76810.1 - 0.37 10.7 20.4 0.67 9.9 0.2 5.0 5 0 0 5 5 5 0 PIG-P Thioredoxin PF00085.20 EFA76811.1 - 6.9e-48 160.9 1.4 1.1e-25 89.6 0.3 2.2 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EFA76811.1 - 2.9e-09 37.3 3.3 0.00042 20.7 0.5 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain Redoxin PF08534.10 EFA76811.1 - 1.4e-08 34.6 1.0 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 2 Redoxin AhpC-TSA PF00578.21 EFA76811.1 - 1e-07 31.9 0.5 6.6e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_6 PF13848.6 EFA76811.1 - 1.5e-06 28.3 0.2 0.014 15.3 0.0 2.4 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFA76811.1 - 9.7e-06 25.1 0.8 0.047 13.0 0.1 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFA76811.1 - 3.1e-05 24.2 0.4 0.4 11.1 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.6 EFA76811.1 - 9.5e-05 22.2 0.0 0.03 14.1 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin TraF PF13728.6 EFA76811.1 - 0.0011 18.8 1.2 0.1 12.4 0.1 2.8 3 0 0 3 3 3 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 EFA76811.1 - 0.026 14.7 2.3 5.1 7.4 0.2 2.6 2 0 0 2 2 2 0 Glutaredoxin DUF836 PF05768.14 EFA76811.1 - 0.098 13.1 0.4 0.62 10.5 0.1 2.1 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) Amidohydro_1 PF01979.20 EFA76812.1 - 1.8e-59 201.8 0.9 2.4e-59 201.4 0.9 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFA76812.1 - 7.9e-09 35.5 1.4 3.5e-07 30.0 0.0 2.6 2 1 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 EFA76812.1 - 0.0085 15.4 2.6 0.045 13.1 0.0 2.4 3 0 0 3 3 3 1 Adenosine/AMP deaminase F-box-like PF12937.7 EFA76813.1 - 0.0017 18.2 0.6 0.0024 17.7 0.6 1.3 1 0 0 1 1 1 1 F-box-like Vip3A_N PF12495.8 EFA76813.1 - 0.0096 15.8 0.2 0.011 15.7 0.2 1.1 1 0 0 1 1 1 1 Vegetative insecticide protein 3A N terminal F-box PF00646.33 EFA76813.1 - 0.021 14.7 0.8 0.042 13.7 0.2 1.7 2 0 0 2 2 2 0 F-box domain NOG1_N PF17835.1 EFA76814.1 - 1.4e-40 138.9 0.2 1.4e-40 138.9 0.2 2.1 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EFA76814.1 - 4.5e-20 71.4 5.8 1.3e-19 69.9 5.8 1.9 1 0 0 1 1 1 1 NOGCT (NUC087) domain PI3K_1B_p101 PF10486.9 EFA76814.1 - 0.058 11.2 6.2 0.076 10.8 6.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Transformer PF06495.11 EFA76814.1 - 0.066 13.3 11.0 0.16 12.0 11.0 1.6 1 0 0 1 1 1 0 Fruit fly transformer protein Pkinase_Tyr PF07714.17 EFA76815.1 - 6.7e-54 182.9 0.0 8.8e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA76815.1 - 1.7e-43 148.9 0.0 2.6e-43 148.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Tmemb_40 PF10160.9 EFA76815.1 - 0.00045 19.8 6.5 0.001 18.6 6.5 1.6 1 0 0 1 1 1 1 Predicted membrane protein Haspin_kinase PF12330.8 EFA76815.1 - 0.047 12.6 0.0 0.077 11.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EFA76815.1 - 0.21 10.3 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Cofilin_ADF PF00241.20 EFA76816.1 - 1.1e-34 118.8 0.0 1.2e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Resolvase PF00239.21 EFA76817.1 - 0.00052 20.1 0.0 0.0019 18.3 0.0 1.9 1 0 0 1 1 1 1 Resolvase, N terminal domain COPI_C PF06957.11 EFA76817.1 - 0.26 10.0 2.7 0.46 9.2 2.7 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus EF-hand_8 PF13833.6 EFA76818.1 - 2.5e-06 27.2 0.0 3.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair Metallophos PF00149.28 EFA76819.1 - 1.5e-15 58.2 2.1 2.8e-15 57.4 2.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFA76819.1 - 2.4e-15 57.1 0.2 7.8e-15 55.5 0.0 2.0 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EFA76819.1 - 3.4e-15 56.4 0.2 9.7e-15 54.9 0.2 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Phage_Mu_Gp45 PF06890.12 EFA76820.1 - 0.069 12.9 0.0 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage Mu Gp45 protein EF-hand_6 PF13405.6 EFA76821.1 - 5e-15 54.1 2.8 3.4e-06 26.6 0.0 3.4 4 1 1 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 EFA76821.1 - 6.2e-14 52.2 0.0 1.4e-05 25.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFA76821.1 - 1.2e-12 46.4 1.8 5.8e-05 22.4 0.1 4.0 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 EFA76821.1 - 5e-11 42.3 2.5 2.5e-05 24.0 0.0 3.5 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA76821.1 - 3e-06 26.5 1.2 0.076 12.5 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 EFA76821.1 - 0.00013 22.3 0.0 0.087 13.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SapB_1 PF05184.15 EFA76821.1 - 0.016 15.2 0.1 2.5 8.2 0.0 3.1 3 0 0 3 3 3 0 Saposin-like type B, region 1 UPF0154 PF03672.13 EFA76821.1 - 0.019 15.0 0.0 4.3 7.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EFA76821.1 - 0.034 14.3 0.0 0.066 13.3 0.0 1.5 1 0 0 1 1 1 0 Ca2+ insensitive EF hand MMM1 PF10296.9 EFA76822.1 - 3.7e-09 36.1 0.1 4.4e-09 35.8 0.1 1.0 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 DIOX_N PF14226.6 EFA76823.1 - 7.4e-31 107.4 0.0 1e-30 106.9 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFA76823.1 - 1.3e-22 80.2 0.0 2.4e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DAP_epimerase PF01678.19 EFA76824.1 - 9e-27 93.7 0.4 1.5e-26 92.9 0.4 1.4 1 0 0 1 1 1 1 Diaminopimelate epimerase MPC PF03650.13 EFA76825.1 - 5.3e-17 61.9 0.0 6.8e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers CYSTM PF12734.7 EFA76825.1 - 0.051 13.9 0.9 0.051 13.9 0.9 1.7 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance MPC PF03650.13 EFA76827.1 - 1.7e-18 66.8 0.6 1.7e-18 66.8 0.6 1.9 2 0 0 2 2 2 1 Mitochondrial pyruvate carriers DUF4397 PF14344.6 EFA76827.1 - 1.1e-11 45.5 0.3 2.3e-10 41.3 0.2 2.4 2 1 1 3 3 3 2 Domain of unknown function (DUF4397) Vac_ImportDeg PF09783.9 EFA76827.1 - 0.017 15.0 1.4 0.021 14.6 0.1 1.8 2 0 0 2 2 2 0 Vacuolar import and degradation protein Phage_TAC_8 PF10666.9 EFA76828.1 - 0.099 12.9 3.8 1.5 9.1 0.0 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Gp14 ()A118 AAA_lid_3 PF17862.1 EFA76829.1 - 1.3e-26 92.1 0.4 1.7e-15 56.5 0.1 2.4 2 0 0 2 2 2 2 AAA+ lid domain AAA PF00004.29 EFA76829.1 - 2.2e-26 92.8 0.9 1.5e-15 57.8 0.0 2.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EFA76829.1 - 0.02 15.0 0.1 0.45 10.6 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain DUF111 PF01969.17 EFA76829.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF111 ARID PF01388.21 EFA76830.1 - 1.9e-13 50.9 0.3 5.2e-13 49.5 0.3 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain REJ PF02010.15 EFA76831.1 - 1.1e-43 149.7 11.5 2e-40 139.0 0.3 2.9 2 1 1 3 3 3 2 REJ domain Glycos_transf_2 PF00535.26 EFA76831.1 - 3.4e-25 88.8 0.0 1.8e-24 86.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFA76831.1 - 2.6e-12 47.1 0.0 5.7e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFA76831.1 - 3.7e-12 46.3 0.1 1.5e-11 44.3 0.1 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 TIG PF01833.24 EFA76831.1 - 1.6e-08 34.5 3.4 1.6e-08 34.5 3.4 3.8 4 0 0 4 4 4 1 IPT/TIG domain Glyco_transf_21 PF13506.6 EFA76831.1 - 0.00011 21.7 0.0 0.00025 20.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 GPS PF01825.21 EFA76831.1 - 0.00045 20.7 1.9 0.0012 19.3 1.9 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Glyco_transf_7C PF02709.14 EFA76831.1 - 0.0016 18.1 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase EphA2_TM PF14575.6 EFA76831.1 - 0.0042 17.9 0.0 0.014 16.3 0.0 1.9 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TPR_19 PF14559.6 EFA76831.1 - 0.0055 17.2 2.2 0.15 12.6 0.1 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Insulin_TMD PF17870.1 EFA76831.1 - 0.011 15.8 0.3 0.036 14.1 0.3 1.9 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Glycos_transf_1 PF00534.20 EFA76831.1 - 0.023 14.2 0.1 1.5 8.3 0.0 3.6 4 0 0 4 4 4 0 Glycosyl transferases group 1 FAM176 PF14851.6 EFA76831.1 - 0.056 13.1 3.4 0.076 12.7 1.8 2.1 2 0 0 2 2 1 0 FAM176 family Glyco_transf_4 PF13439.6 EFA76831.1 - 0.057 13.4 0.0 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 DUF5316 PF17247.2 EFA76831.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5316) TPR_14 PF13428.6 EFA76831.1 - 0.26 12.2 3.7 2.7 9.1 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76831.1 - 0.66 10.3 5.7 0.18 12.1 0.1 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat LapA_dom PF06305.11 EFA76831.1 - 0.77 9.6 4.9 0.31 10.9 0.1 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain TFIIA PF03153.13 EFA76833.1 - 0.031 14.3 36.2 0.043 13.8 36.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YrzO PF14142.6 EFA76833.1 - 0.044 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 YrzO-like protein LAP1C PF05609.12 EFA76833.1 - 2 7.4 30.8 2.6 7.0 30.8 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DZR PF12773.7 EFA76834.1 - 0.0013 18.7 0.5 0.0024 17.9 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EFA76834.1 - 0.0055 16.4 4.3 0.0095 15.6 4.3 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zf-RanBP PF00641.18 EFA76834.1 - 0.0074 15.6 2.6 0.013 14.8 2.6 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zinc_ribbon_15 PF17032.5 EFA76834.1 - 0.0092 16.7 0.3 0.018 15.7 0.2 1.6 2 0 0 2 2 2 1 zinc-ribbon family UPF0547 PF10571.9 EFA76834.1 - 0.11 12.6 1.3 0.2 11.7 1.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Sel1 PF08238.12 EFA76835.1 - 1.5e-21 76.3 16.6 4.7e-08 33.5 0.7 6.4 7 0 0 7 7 7 5 Sel1 repeat MIT PF04212.18 EFA76835.1 - 0.2 11.7 2.3 8.1 6.6 0.0 3.5 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Topoisom_I_N PF02919.15 EFA76835.1 - 0.31 10.5 9.4 0.56 9.7 9.4 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment PNISR PF15996.5 EFA76835.1 - 6.7 6.9 13.3 9.8 6.4 13.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Gelsolin PF00626.22 EFA76836.1 - 2.6e-34 117.0 0.1 1.1e-06 28.4 0.0 5.8 5 1 1 6 6 6 5 Gelsolin repeat VHP PF02209.19 EFA76836.1 - 5.1e-15 55.2 0.5 1.3e-14 53.9 0.5 1.8 1 0 0 1 1 1 1 Villin headpiece domain ComGG PF14173.6 EFA76836.1 - 0.058 13.8 0.1 0.18 12.2 0.1 1.8 1 0 0 1 1 1 0 ComG operon protein 7 Tail_spike_N PF18668.1 EFA76836.1 - 0.058 13.3 0.7 17 5.4 0.0 3.9 4 0 0 4 4 4 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain NST1 PF13945.6 EFA76838.1 - 5 7.2 21.2 2.6 8.1 13.7 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator TFIIA PF03153.13 EFA76839.1 - 0.015 15.3 32.6 0.018 15.0 32.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 EFA76839.1 - 0.84 9.7 4.0 1 9.4 4.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region INTS2 PF14750.6 EFA76840.1 - 1.3e-69 235.0 31.5 2.4e-47 161.2 20.5 5.1 2 2 1 3 3 3 3 Integrator complex subunit 2 DUF2065 PF09838.9 EFA76840.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) Secretin_N_2 PF07655.13 EFA76840.1 - 4.7 7.8 42.3 0.46 11.1 2.3 5.3 5 0 0 5 5 5 0 Secretin N-terminal domain LCM PF04072.14 EFA76841.1 - 4.2e-35 121.4 0.0 8.9e-35 120.3 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase LCM PF04072.14 EFA76842.1 - 1.6e-34 119.5 0.0 4.4e-34 118.1 0.0 1.8 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase LCM PF04072.14 EFA76843.1 - 1.9e-37 129.0 0.0 5.9e-37 127.4 0.0 1.8 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Epimerase PF01370.21 EFA76844.1 - 1.2e-26 93.7 0.2 2e-26 93.0 0.1 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA76844.1 - 1.1e-24 87.0 0.1 1.6e-24 86.4 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFA76844.1 - 5.7e-20 71.6 0.0 8.7e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFA76844.1 - 1.8e-18 67.1 0.1 1.4e-17 64.1 0.1 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFA76844.1 - 2.9e-15 56.6 0.0 5.5e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFA76844.1 - 1.4e-11 44.1 0.0 4.8e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EFA76844.1 - 8.7e-11 41.6 0.0 1.3e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EFA76844.1 - 1.5e-07 31.3 0.1 4.4e-07 29.7 0.1 1.9 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EFA76844.1 - 1.6e-07 30.7 0.0 2.6e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EFA76844.1 - 1.3e-06 28.5 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EFA76844.1 - 0.014 15.0 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NAD_binding_2 PF03446.15 EFA76844.1 - 0.038 14.2 0.0 0.097 12.8 0.0 1.7 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase RPM2 PF08579.11 EFA76844.1 - 0.46 10.9 0.1 0.46 10.9 0.1 2.3 3 0 0 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) DUF498 PF04430.14 EFA76845.1 - 8.3e-29 99.9 0.0 1.2e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) FOG_N PF15888.5 EFA76845.1 - 0.0044 17.4 0.1 0.0095 16.3 0.1 1.5 1 0 0 1 1 1 1 Folded gastrulation N-terminus Rrp44_CSD1 PF17216.3 EFA76845.1 - 0.043 13.5 0.9 0.043 13.5 0.9 2.0 2 0 0 2 2 2 0 Rrp44-like cold shock domain AFP_2 PF18815.1 EFA76845.1 - 0.5 10.7 0.1 0.5 10.7 0.1 2.9 3 0 0 3 3 3 0 Bacterial antifreeze protein repeat EF-hand_1 PF00036.32 EFA76846.1 - 2e-19 67.6 12.5 2.2e-05 23.6 1.0 5.1 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EFA76846.1 - 1.9e-17 61.6 10.5 0.0001 21.9 0.4 5.0 4 1 1 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 EFA76846.1 - 2.6e-17 63.0 9.2 1.4e-09 38.3 2.7 3.9 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA76846.1 - 1.9e-13 50.0 9.4 1.7e-05 24.6 0.1 3.7 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA76846.1 - 3e-13 48.6 12.0 4.7e-07 29.0 0.0 4.9 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EFA76846.1 - 3.9e-07 30.4 2.8 0.11 12.8 0.0 3.3 2 1 2 4 4 4 4 Secreted protein acidic and rich in cysteine Ca binding region S_100 PF01023.19 EFA76846.1 - 0.00029 20.5 3.3 0.044 13.5 0.7 3.1 2 1 1 3 3 3 2 S-100/ICaBP type calcium binding domain TerB PF05099.13 EFA76846.1 - 0.00063 19.7 0.6 0.29 11.1 0.0 3.3 3 1 1 4 4 4 2 Tellurite resistance protein TerB EF-hand_4 PF12763.7 EFA76846.1 - 0.012 15.5 4.6 0.036 14.0 0.1 2.6 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EFA76846.1 - 0.15 12.4 2.4 7.9 6.9 0.1 3.2 2 1 1 3 3 3 0 EF-hand domain SUIM_assoc PF16619.5 EFA76847.1 - 0.024 14.7 1.5 0.024 14.7 1.5 4.2 3 1 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Sec62 PF03839.16 EFA76847.1 - 2.1 7.8 13.2 10 5.6 0.0 2.8 3 0 0 3 3 3 0 Translocation protein Sec62 FliP PF00813.20 EFA76847.1 - 8.5 6.2 8.1 33 4.3 7.0 2.2 2 0 0 2 2 2 0 FliP family Chlam_PMP PF02415.17 EFA76850.1 - 7.8e-10 38.6 44.3 0.064 13.8 3.6 9.7 9 0 0 9 9 9 5 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SKG6 PF08693.10 EFA76850.1 - 0.0016 17.8 1.1 0.0039 16.6 1.1 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DisA_N PF02457.16 EFA76850.1 - 0.051 13.2 0.1 0.34 10.5 0.0 2.3 2 1 0 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding Pentapeptide_3 PF13576.6 EFA76850.1 - 4.2 7.6 8.0 2.9 8.1 2.5 3.4 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) Adap_comp_sub PF00928.21 EFA76851.1 - 1e-20 74.2 1.4 1.6e-20 73.6 1.4 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Dscam_C PF12355.8 EFA76851.1 - 1.7 9.6 6.1 22 6.0 1.1 2.7 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal ATP_bind_1 PF03029.17 EFA76852.1 - 1.2e-75 254.4 0.0 1.4e-75 254.2 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EFA76852.1 - 6e-05 23.0 0.0 0.08 12.9 0.0 2.3 1 1 0 2 2 2 2 AAA domain CLP1_P PF16575.5 EFA76852.1 - 0.0012 18.7 0.0 0.052 13.3 0.0 2.1 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 EFA76852.1 - 0.0025 17.5 0.0 0.0036 17.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 EFA76852.1 - 0.0028 16.7 0.0 0.0044 16.0 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EFA76852.1 - 0.0032 17.9 0.0 0.0051 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 EFA76852.1 - 0.0041 17.2 0.0 0.0051 16.9 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.7 EFA76852.1 - 0.0067 15.4 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_30 PF13604.6 EFA76852.1 - 0.013 15.3 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFA76852.1 - 0.014 15.7 0.0 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EFA76852.1 - 0.016 14.9 0.0 0.091 12.4 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain KTI12 PF08433.10 EFA76852.1 - 0.021 14.3 0.0 0.064 12.7 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA PF00004.29 EFA76852.1 - 0.028 14.9 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EFA76852.1 - 0.037 13.1 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 EFA76852.1 - 0.037 14.0 0.0 0.057 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PPV_E1_C PF00519.17 EFA76852.1 - 0.045 12.6 0.0 0.062 12.1 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase RNA_helicase PF00910.22 EFA76852.1 - 0.066 13.6 0.0 0.41 11.1 0.0 2.1 2 1 1 3 3 3 0 RNA helicase PhoU_div PF01865.16 EFA76852.1 - 0.099 12.0 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF47 AAA_18 PF13238.6 EFA76852.1 - 0.1 13.2 0.1 0.29 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFA76852.1 - 0.12 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EFA76852.1 - 0.13 11.8 0.3 10 5.6 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B ATPase PF06745.13 EFA76852.1 - 0.13 11.6 0.0 0.29 10.4 0.0 1.4 1 1 0 1 1 1 0 KaiC AAA_19 PF13245.6 EFA76852.1 - 0.16 12.3 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFA76852.1 - 0.2 11.0 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 EFA76852.1 - 0.21 11.2 0.0 0.89 9.1 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Beta-lactamase PF00144.24 EFA76853.1 - 1.8e-40 139.2 0.0 3.2e-40 138.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase PARP PF00644.20 EFA76853.1 - 1.3e-22 80.4 0.0 3.7e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EFA76853.1 - 6.3e-16 58.7 5.1 3.8e-08 33.8 0.9 2.9 2 0 0 2 2 2 2 WWE domain Prothymosin PF03247.14 EFA76853.1 - 0.0064 16.9 1.2 0.014 15.8 1.2 1.6 1 0 0 1 1 1 1 Prothymosin/parathymosin family EGF PF00008.27 EFA76853.1 - 0.59 10.5 3.3 2.5 8.5 2.0 2.3 2 0 0 2 2 2 0 EGF-like domain DUF2845 PF11006.8 EFA76854.1 - 0.044 13.9 0.3 0.05 13.7 0.3 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2845) SGL PF08450.12 EFA76854.1 - 0.048 13.2 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Cyclin PF08613.11 EFA76855.1 - 2.3e-19 70.4 3.7 2.3e-19 70.4 3.7 3.3 2 2 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFA76855.1 - 2.8e-08 33.6 1.8 9.7e-07 28.6 1.8 2.5 1 1 0 1 1 1 1 Cyclin, N-terminal domain DUF1699 PF08004.11 EFA76855.1 - 0.0073 16.0 0.8 0.018 14.7 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1699) Cactin_mid PF10312.9 EFA76855.1 - 0.087 12.5 0.0 0.16 11.7 0.0 1.5 1 1 0 1 1 1 0 Conserved mid region of cactin NGP1NT PF08153.12 EFA76856.1 - 5.6e-41 139.7 0.0 5.6e-41 139.7 0.0 3.2 3 0 0 3 3 3 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EFA76856.1 - 1.1e-14 54.5 5.2 4.4e-13 49.3 0.0 3.6 3 0 0 3 3 3 2 50S ribosome-binding GTPase Arf PF00025.21 EFA76856.1 - 7.5e-05 22.3 0.1 0.038 13.4 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family FeoB_N PF02421.18 EFA76856.1 - 0.00023 20.7 0.0 0.0026 17.3 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA76856.1 - 0.0017 18.3 0.0 0.0017 18.3 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase Dicty_REP PF05086.12 EFA76856.1 - 0.29 9.0 43.8 0.11 10.5 14.3 2.2 1 1 1 2 2 2 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EFA76856.1 - 1.7 8.7 9.2 5 7.1 9.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AAA_11 PF13086.6 EFA76857.1 - 1.3e-77 261.1 0.8 1.3e-77 261.1 0.8 2.3 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EFA76857.1 - 1.5e-63 214.0 0.0 3.5e-63 212.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA76857.1 - 1.3e-11 45.0 0.1 1.9e-10 41.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA76857.1 - 4.2e-11 42.9 0.0 3.5e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EFA76857.1 - 0.00013 21.8 0.1 0.068 12.9 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EFA76857.1 - 0.018 15.3 0.0 0.29 11.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain Helicase_RecD PF05127.14 EFA76857.1 - 0.019 14.9 0.0 4.3 7.2 0.0 2.9 2 0 0 2 2 2 0 Helicase AAA PF00004.29 EFA76857.1 - 0.021 15.3 0.7 0.23 11.9 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFA76857.1 - 0.041 13.9 0.1 0.18 11.8 0.1 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFA76857.1 - 0.051 13.2 0.0 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFA76857.1 - 0.067 12.9 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DASH_Dad1 PF08649.10 EFA76857.1 - 0.086 13.0 0.2 0.57 10.4 0.1 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad1 FlaC_arch PF05377.11 EFA76857.1 - 0.097 13.1 2.1 10 6.6 0.1 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) RNA_helicase PF00910.22 EFA76857.1 - 0.11 12.9 0.1 7.9 6.9 0.0 3.2 3 0 0 3 3 3 0 RNA helicase AAA_16 PF13191.6 EFA76857.1 - 0.18 12.1 0.0 0.5 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain HIP1_clath_bdg PF16515.5 EFA76857.1 - 1.4 9.6 5.4 0.39 11.4 1.2 2.4 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Snapin_Pallidin PF14712.6 EFA76857.1 - 1.8 9.1 8.3 2 8.9 0.8 3.5 4 0 0 4 4 2 0 Snapin/Pallidin B56 PF01603.20 EFA76858.1 - 2e-161 537.6 5.1 2.6e-161 537.3 5.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Ank_2 PF12796.7 EFA76859.1 - 2.5e-93 306.8 36.3 8.4e-12 45.5 0.1 15.8 7 4 8 15 15 15 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76859.1 - 2.3e-84 276.8 31.0 8.5e-09 35.8 0.0 20.7 14 5 8 23 23 23 19 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76859.1 - 1.9e-69 228.8 21.9 4.7e-12 45.9 0.1 20.4 12 3 8 20 20 20 13 Ankyrin repeats (many copies) PARP PF00644.20 EFA76859.1 - 2.7e-58 196.8 0.0 2.7e-58 196.8 0.0 5.8 3 1 1 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain Ank_3 PF13606.6 EFA76859.1 - 2.5e-55 177.9 29.1 0.00076 19.8 0.0 23.6 24 0 0 24 24 24 11 Ankyrin repeat Ank PF00023.30 EFA76859.1 - 2.6e-50 166.7 40.3 0.0025 18.2 0.0 23.8 28 0 0 28 28 28 12 Ankyrin repeat PARP_reg PF02877.14 EFA76859.1 - 7.5e-31 107.0 2.7 7.5e-31 107.0 2.7 2.4 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFA76859.1 - 5.5e-13 48.8 1.6 5.5e-13 48.8 1.6 4.4 3 1 1 4 4 4 1 WGR domain TFIIA PF03153.13 EFA76859.1 - 0.00013 22.2 16.8 0.00013 22.2 16.8 4.5 3 1 2 5 5 5 1 Transcription factor IIA, alpha/beta subunit NAD_binding_8 PF13450.6 EFA76860.1 - 1.3e-05 25.4 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFA76860.1 - 0.00035 19.9 0.0 0.00061 19.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EFA76860.1 - 0.00055 19.3 0.0 0.0012 18.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EFA76860.1 - 0.0012 18.0 0.0 0.19 10.8 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EFA76860.1 - 0.0057 15.8 0.4 0.016 14.3 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain GDI PF00996.18 EFA76860.1 - 0.0062 15.1 0.1 0.01 14.4 0.1 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor Pyr_redox_2 PF07992.14 EFA76860.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFA76860.1 - 0.014 14.7 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DAO PF01266.24 EFA76860.1 - 0.02 14.5 0.2 0.76 9.3 0.1 2.4 1 1 0 2 2 2 0 FAD dependent oxidoreductase ThiF PF00899.21 EFA76860.1 - 0.049 13.0 0.1 0.12 11.7 0.1 1.6 1 0 0 1 1 1 0 ThiF family MMR_HSR1 PF01926.23 EFA76861.1 - 4.6e-17 62.2 1.2 8.5e-15 54.8 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA76861.1 - 7.4e-06 25.6 0.1 2.4e-05 23.9 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA76861.1 - 3.3e-05 23.9 7.6 0.00017 21.5 0.2 3.1 2 1 1 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EFA76861.1 - 4.5e-05 23.1 4.7 0.092 12.3 0.3 3.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain IIGP PF05049.13 EFA76861.1 - 6.6e-05 22.1 1.2 0.00029 20.0 1.2 2.1 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MCM PF00493.23 EFA76861.1 - 0.0093 15.1 0.2 0.052 12.6 0.1 2.1 1 1 1 2 2 2 1 MCM P-loop domain Roc PF08477.13 EFA76861.1 - 0.058 13.6 1.1 0.65 10.2 0.0 2.9 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EFA76861.1 - 0.064 13.6 0.1 0.2 12.0 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 EFA76861.1 - 0.77 9.5 7.0 6.6 6.4 2.1 3.1 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EFA76861.1 - 1.3 9.5 5.6 6.2 7.4 0.0 3.5 3 1 1 4 4 4 0 AAA domain Barttin PF15462.6 EFA76861.1 - 2.4 7.9 7.1 82 2.9 7.1 2.2 1 1 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Rad10 PF03834.14 EFA76862.1 - 8.3e-29 99.9 0.0 2.1e-28 98.6 0.0 1.7 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EFA76862.1 - 1.4e-05 25.6 0.0 2.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain LCM PF04072.14 EFA76863.1 - 5.7e-33 114.5 0.0 7.7e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Hormone_4 PF00220.17 EFA76863.1 - 8 6.7 6.1 16 5.8 1.2 3.1 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Kelch_6 PF13964.6 EFA76864.1 - 5.3e-14 51.9 10.5 5.9e-09 35.9 0.2 5.2 4 1 1 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFA76864.1 - 0.0077 16.2 1.0 0.41 10.7 0.1 2.9 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 EFA76864.1 - 0.033 13.8 6.4 0.038 13.6 0.1 3.0 3 1 0 3 3 3 0 Kelch motif DLP_helical PF18709.1 EFA76864.1 - 0.072 12.3 14.2 0.011 15.0 9.9 1.7 2 0 0 2 2 2 0 Dynamin-like helical domain zf-B_box PF00643.24 EFA76864.1 - 0.23 11.6 14.9 0.61 10.3 14.9 1.8 1 0 0 1 1 1 0 B-box zinc finger Kelch_5 PF13854.6 EFA76864.1 - 0.6 10.2 2.9 2.9 8.0 0.2 2.8 2 0 0 2 2 2 0 Kelch motif SdrD_B PF17210.3 EFA76865.1 - 1.6e-11 44.4 0.4 3.5e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA76865.1 - 0.0055 17.0 0.0 0.021 15.1 0.0 2.0 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 EFA76866.1 - 3e-19 69.3 11.6 9.7e-08 32.2 0.5 3.6 3 0 0 3 3 3 3 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA76866.1 - 2.3e-08 34.2 1.6 0.012 15.9 0.1 3.8 3 1 0 3 3 3 2 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA76866.1 - 5.6e-05 23.4 2.2 0.0072 16.6 0.1 3.5 2 1 1 3 3 3 1 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA76866.1 - 0.0094 15.9 2.9 0.75 9.8 0.0 3.8 4 0 0 4 4 4 1 CarboxypepD_reg-like domain bMG3 PF11974.8 EFA76866.1 - 0.17 11.9 0.0 35 4.5 0.0 2.8 3 0 0 3 3 3 0 Bacterial alpha-2-macroglobulin MG3 domain Big_1 PF02369.16 EFA76866.1 - 1.3 9.0 6.3 22 5.2 0.1 4.6 3 1 0 3 3 3 0 Bacterial Ig-like domain (group 1) fn3_3 PF14686.6 EFA76866.1 - 4.7 7.1 7.0 2.1 8.2 0.0 3.8 4 0 0 4 4 4 0 Polysaccharide lyase family 4, domain II C9orf72-like PF15019.6 EFA76867.1 - 7.6e-30 104.3 1.2 7.6e-30 104.3 1.2 1.5 2 0 0 2 2 2 1 C9orf72-like protein family ABC2_membrane PF01061.24 EFA76868.1 - 3.1e-76 255.5 57.5 7.7e-43 146.4 21.2 2.6 2 0 0 2 2 2 2 ABC-2 type transporter PDR_CDR PF06422.12 EFA76868.1 - 7.8e-26 89.8 10.2 1e-20 73.4 0.0 3.4 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.27 EFA76868.1 - 4.9e-25 88.6 0.1 3.4e-16 60.0 0.0 3.7 3 1 1 4 4 4 3 ABC transporter ABC_trans_N PF14510.6 EFA76868.1 - 3.5e-10 40.4 0.1 9.3e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EFA76868.1 - 2.1e-06 27.1 13.5 2.1e-06 27.1 13.5 3.6 3 1 0 3 3 3 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFA76868.1 - 0.039 13.9 0.1 6.5 6.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Menin PF05053.13 EFA76869.1 - 2.1 6.6 11.5 2.4 6.4 11.5 1.1 1 0 0 1 1 1 0 Menin Membralin PF09746.9 EFA76869.1 - 7.7 5.4 6.4 9.2 5.2 6.4 1.2 1 0 0 1 1 1 0 Tumour-associated protein UPF0020 PF01170.18 EFA76870.1 - 5.3e-08 32.8 0.0 8.5e-06 25.6 0.0 2.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EFA76870.1 - 6e-07 29.4 0.0 0.00035 20.4 0.0 3.0 2 1 0 2 2 2 2 DNA methylase Acyl-CoA_dh_1 PF00441.24 EFA76871.1 - 2.8e-45 154.2 0.2 4e-45 153.7 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFA76871.1 - 1.4e-28 99.8 0.0 3e-28 98.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFA76871.1 - 3e-26 91.5 0.0 8.1e-26 90.1 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFA76871.1 - 1.6e-19 70.5 0.0 2.6e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF1772 PF08592.11 EFA76871.1 - 0.0059 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF2496 PF10689.9 EFA76871.1 - 0.075 12.8 0.1 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2496) HpaB_N PF11794.8 EFA76871.1 - 0.078 12.6 0.1 0.2 11.3 0.1 1.6 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal U-box PF04564.15 EFA76873.1 - 1.2e-08 35.0 0.1 1.9e-08 34.3 0.1 1.5 1 1 0 1 1 1 1 U-box domain zf-Nse PF11789.8 EFA76873.1 - 0.01 15.6 0.1 0.039 13.8 0.0 1.9 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EFA76873.1 - 0.02 15.2 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFA76873.1 - 0.088 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA76873.1 - 0.17 12.2 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Ring finger domain Pur_ac_phosph_N PF16656.5 EFA76874.1 - 4.8e-17 62.3 2.9 6e-17 62.0 1.2 2.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFA76874.1 - 3.2e-16 59.9 0.3 1.1e-15 58.2 0.0 2.1 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 EFA76874.1 - 5.9e-16 59.6 4.1 1.2e-15 58.6 3.9 1.6 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase PhoD PF09423.10 EFA76874.1 - 0.016 14.3 0.0 0.065 12.2 0.0 1.8 2 0 0 2 2 2 0 PhoD-like phosphatase ANTH PF07651.16 EFA76875.1 - 4.7e-35 120.9 0.8 4.7e-35 120.9 0.8 2.8 3 1 0 3 3 3 1 ANTH domain ENTH PF01417.20 EFA76875.1 - 0.00025 21.1 0.5 0.00088 19.3 0.0 2.2 2 0 0 2 2 2 1 ENTH domain Acetyltransf_3 PF13302.7 EFA76876.1 - 2.9e-17 63.6 0.0 3.7e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA76876.1 - 0.00036 20.7 0.1 0.00051 20.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PTEN_C2 PF10409.9 EFA76878.1 - 2.2e-06 27.5 0.0 7.9e-06 25.7 0.0 2.0 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EFA76878.1 - 1.1e-05 25.3 0.1 1.1e-05 25.3 0.1 3.0 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA76878.1 - 0.0032 17.1 0.0 0.0032 17.1 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFA76878.1 - 0.014 15.4 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF3799 PF12684.7 EFA76878.1 - 0.018 14.8 1.0 0.26 11.0 0.1 2.2 2 0 0 2 2 2 0 PDDEXK-like domain of unknown function (DUF3799) PTPlike_phytase PF14566.6 EFA76878.1 - 0.28 11.3 1.4 1.2 9.2 0.0 2.5 3 0 0 3 3 3 0 Inositol hexakisphosphate SR-25 PF10500.9 EFA76878.1 - 7.8 6.0 8.1 17 4.9 8.1 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FERM_C PF09380.10 EFA76879.1 - 0.039 14.3 0.1 0.057 13.8 0.1 1.3 1 0 0 1 1 1 0 FERM C-terminal PH-like domain RCC1_2 PF13540.6 EFA76880.1 - 2.2e-34 116.5 16.5 1.1e-07 31.4 0.1 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RhoGAP PF00620.27 EFA76880.1 - 2.4e-34 118.4 0.7 4.8e-34 117.4 0.0 1.8 2 1 0 2 2 2 1 RhoGAP domain RCC1 PF00415.18 EFA76880.1 - 3.4e-31 107.6 15.7 3.2e-09 37.3 0.0 8.8 7 3 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat LCAT PF02450.15 EFA76881.1 - 2.1e-63 214.8 0.4 1.5e-54 185.7 0.1 2.3 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase VKOR PF07884.14 EFA76881.1 - 8.4e-18 64.7 15.0 1.9e-17 63.6 15.0 1.6 1 0 0 1 1 1 1 Vitamin K epoxide reductase family PGAP1 PF07819.13 EFA76881.1 - 5.9e-06 26.2 0.0 1.7e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein Hydrolase_4 PF12146.8 EFA76881.1 - 0.0021 17.4 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EFA76881.1 - 0.0067 16.0 0.0 0.017 14.6 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EFA76881.1 - 0.018 14.7 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 EFA76881.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase MgtC PF02308.16 EFA76881.1 - 1.5 9.2 5.1 3.1 8.2 5.1 1.5 1 0 0 1 1 1 0 MgtC family Ras PF00071.22 EFA76882.1 - 4.4e-50 169.4 0.0 1.2e-49 168.1 0.0 1.7 2 0 0 2 2 2 1 Ras family BTB PF00651.31 EFA76882.1 - 6.5e-33 113.3 4.0 1e-18 67.6 0.1 3.6 3 1 0 3 3 3 2 BTB/POZ domain Roc PF08477.13 EFA76882.1 - 1.7e-18 66.9 0.0 4.3e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase BACK PF07707.15 EFA76882.1 - 0.0004 20.5 0.2 0.015 15.4 0.1 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch Arf PF00025.21 EFA76882.1 - 0.00093 18.7 0.0 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA76882.1 - 0.014 15.5 0.0 4.1 7.5 0.0 2.9 3 0 0 3 3 3 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA76883.1 - 3.3e-64 216.0 0.0 6.9e-64 215.0 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFA76883.1 - 8.5e-25 86.6 0.1 1.7e-24 85.7 0.1 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EFA76883.1 - 6.9e-21 74.1 0.0 2.1e-20 72.6 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFA76883.1 - 1.4e-10 41.4 3.0 3.1e-10 40.3 1.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 EFA76883.1 - 1.3e-07 31.4 0.0 3.5e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV RF3_C PF16658.5 EFA76883.1 - 5.1e-06 26.3 0.0 1.2e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFA76883.1 - 5.3e-05 23.3 0.1 0.00013 22.0 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase dUTPase PF00692.19 EFA76884.1 - 0.0023 17.6 0.0 0.0037 16.9 0.0 1.3 1 0 0 1 1 1 1 dUTPase Endotoxin_N PF03945.14 EFA76885.1 - 1.3e-95 319.3 7.2 5.2e-95 317.4 4.1 2.3 2 0 0 2 2 2 2 delta endotoxin, N-terminal domain Endotoxin_N PF03945.14 EFA76886.1 - 3.1e-44 151.3 9.0 6.5e-44 150.3 9.0 1.6 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain IF4E PF01652.18 EFA76886.1 - 0.071 12.9 1.3 0.32 10.8 0.0 2.5 3 0 0 3 3 3 0 Eukaryotic initiation factor 4E DUP PF00674.18 EFA76886.1 - 0.072 13.2 5.8 0.27 11.4 0.8 2.6 2 0 0 2 2 2 0 DUP family Endotoxin_N PF03945.14 EFA76887.1 - 2.7e-98 328.1 12.0 2.7e-98 328.1 12.0 2.3 2 0 0 2 2 2 1 delta endotoxin, N-terminal domain Intimin_C PF07979.11 EFA76887.1 - 0.07 13.6 1.9 0.12 12.9 0.3 2.2 2 0 0 2 2 2 0 Intimin C-type lectin domain TFCD_C PF12612.8 EFA76888.1 - 7.5e-25 87.9 0.3 3.5e-24 85.7 0.3 2.2 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal Laminin_G_3 PF13385.6 EFA76888.1 - 2.9e-17 63.2 0.0 6.8e-17 62.0 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_transf_10 PF00852.19 EFA76888.1 - 1.4e-16 60.7 0.2 3.6e-16 59.4 0.2 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 EFA76888.1 - 0.01 16.3 0.1 0.033 14.6 0.1 1.8 1 0 0 1 1 1 0 Fucosyltransferase, N-terminal HEAT PF02985.22 EFA76888.1 - 0.018 15.2 1.1 68 4.1 0.0 6.3 8 0 0 8 8 8 0 HEAT repeat Cnd3 PF12719.7 EFA76888.1 - 0.038 13.2 0.1 0.038 13.2 0.1 3.2 3 1 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain Cor1 PF04803.12 EFA76888.1 - 0.26 11.5 4.8 0.21 11.8 0.2 3.1 3 0 0 3 3 3 0 Cor1/Xlr/Xmr conserved region MFS_1 PF07690.16 EFA76889.1 - 7.8e-37 127.0 22.8 1e-36 126.6 22.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA76889.1 - 4.3e-10 39.1 20.4 8.7e-07 28.2 6.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 EFA76889.1 - 0.0039 15.8 17.4 0.12 10.8 5.0 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein UPF0147 PF03685.13 EFA76890.1 - 0.0044 17.0 4.9 0.56 10.3 0.2 3.6 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0147) Fst_toxin PF13955.6 EFA76890.1 - 0.054 13.4 0.1 0.17 11.8 0.1 1.9 1 0 0 1 1 1 0 Toxin Fst, type I toxin-antitoxin system RTTN_N PF14726.6 EFA76890.1 - 0.062 14.1 1.9 2.1 9.2 0.5 3.2 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning CBFD_NFYB_HMF PF00808.23 EFA76891.1 - 3.3e-18 65.7 0.8 4.8e-18 65.2 0.8 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFA76891.1 - 4.1e-14 53.1 0.5 9.5e-14 51.9 0.4 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Cyclin_N PF00134.23 EFA76892.1 - 4.9e-09 36.0 0.5 4.9e-09 36.0 0.5 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain 30K_MP_C_Ter PF11330.8 EFA76892.1 - 0.11 11.7 2.9 0.28 10.5 2.9 1.6 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins Pex14_N PF04695.13 EFA76892.1 - 0.54 10.9 30.1 0.3 11.7 8.8 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 EFA76892.1 - 0.66 9.9 32.4 0.27 11.2 18.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SOG2 PF10428.9 EFA76892.1 - 1.1 8.4 34.7 0.16 11.1 13.5 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein SPX PF03105.19 EFA76892.1 - 2.9 7.7 26.1 0.94 9.3 8.8 2.2 2 0 0 2 2 2 0 SPX domain Presenilin PF01080.17 EFA76892.1 - 8.4 5.0 17.5 7.5 5.2 8.5 2.1 2 0 0 2 2 2 0 Presenilin RNase_HII PF01351.18 EFA76894.1 - 6.6e-51 173.0 0.3 1.9e-50 171.5 0.0 2.0 2 0 0 2 2 1 1 Ribonuclease HII DAP3 PF10236.9 EFA76894.1 - 1.8e-05 24.1 1.6 0.079 12.1 0.0 3.4 3 0 0 3 3 3 2 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 EFA76894.1 - 4.5e-05 23.8 0.6 0.84 10.0 0.0 3.6 4 0 0 4 4 2 2 RNA helicase AAA_11 PF13086.6 EFA76894.1 - 0.00014 21.7 8.9 1.6 8.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 EFA76894.1 - 0.00052 19.6 0.1 0.43 10.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region T2SSE PF00437.20 EFA76894.1 - 0.001 18.2 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 EFA76894.1 - 0.0012 19.2 0.4 1.4 9.3 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 EFA76894.1 - 0.003 17.6 0.0 0.094 12.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 EFA76894.1 - 0.0065 15.4 0.7 0.44 9.4 0.0 3.1 3 0 0 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 EFA76894.1 - 0.0077 16.2 0.0 2.7 7.9 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EFA76894.1 - 0.0094 16.2 0.0 8.5 6.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFA76894.1 - 0.0097 15.6 0.0 1.7 8.4 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFA76894.1 - 0.0098 15.6 0.0 0.36 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFA76894.1 - 0.014 15.1 0.0 7.1 6.3 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_19 PF13245.6 EFA76894.1 - 0.016 15.5 0.0 0.37 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFA76894.1 - 0.017 15.1 0.0 2.1 8.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SDP_N PF12278.8 EFA76894.1 - 0.022 14.9 4.9 0.078 13.1 4.9 1.9 1 0 0 1 1 1 0 Sex determination protein N terminal SAM_PNT PF02198.16 EFA76894.1 - 0.039 13.9 0.4 0.11 12.4 0.0 2.0 2 0 0 2 2 1 0 Sterile alpha motif (SAM)/Pointed domain ATPase_2 PF01637.18 EFA76894.1 - 0.047 13.6 0.2 0.37 10.7 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EFA76894.1 - 0.051 13.5 0.0 6.5 6.6 0.0 2.5 2 0 0 2 2 2 0 NTPase Sigma54_activat PF00158.26 EFA76894.1 - 0.12 12.1 0.0 8.5 6.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain MID_MedPIWI PF18296.1 EFA76894.1 - 0.3 10.9 10.2 0.15 11.8 5.1 2.4 2 0 0 2 2 2 0 MID domain of medPIWI RMP PF14996.6 EFA76894.1 - 0.73 10.0 8.6 40 4.4 8.5 2.5 2 0 0 2 2 2 0 Retinal Maintenance DUF3347 PF11827.8 EFA76894.1 - 0.75 10.0 8.6 1.8 8.7 8.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) CobT PF06213.12 EFA76894.1 - 1.6 8.0 10.0 2.6 7.3 10.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 EFA76894.1 - 3.7 6.2 7.9 6.5 5.4 7.9 1.3 1 0 0 1 1 1 0 Presenilin Tmemb_9 PF05434.11 EFA76894.1 - 6.2 6.7 9.1 13 5.6 9.1 1.5 1 0 0 1 1 1 0 TMEM9 DUF4175 PF13779.6 EFA76894.1 - 6.5 4.5 11.2 9.4 4.0 11.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) BioW PF03744.13 EFA76895.1 - 0.034 13.7 0.0 0.038 13.6 0.0 1.0 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase DUF3439 PF11921.8 EFA76896.1 - 0.9 9.5 11.9 0.89 9.5 11.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 EFA76896.1 - 1.6 6.9 13.9 1.5 6.9 13.9 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Tir_receptor_C PF07489.11 EFA76896.1 - 1.7 8.6 8.9 1.7 8.5 8.9 1.0 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EFA76896.1 - 3.1 5.7 6.4 3.2 5.6 6.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2185 PF09951.9 EFA76897.1 - 5.8e-31 106.2 1.2 4.2e-30 103.4 0.2 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF2185) DUF2314 PF10077.9 EFA76897.1 - 2.9e-06 27.4 0.0 6.9e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2314) SpoIIE PF07228.12 EFA76898.1 - 8.8e-11 42.1 0.1 3.1e-10 40.3 0.0 2.0 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EFA76898.1 - 7.6e-05 22.5 0.1 0.0049 16.5 0.0 4.4 4 1 2 6 6 6 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFA76898.1 - 0.00045 19.9 0.1 0.0022 17.7 0.1 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C CPSF73-100_C PF11718.8 EFA76898.1 - 0.5 9.9 8.1 0.33 10.5 0.5 2.9 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DUF836 PF05768.14 EFA76899.1 - 2.2e-09 37.6 0.8 3e-09 37.2 0.8 1.3 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EFA76899.1 - 3.9e-05 23.8 1.2 8.2e-05 22.7 0.2 1.9 2 0 0 2 2 2 1 Glutaredoxin TPR_1 PF00515.28 EFA76900.1 - 3.2e-16 58.4 17.6 5.3e-05 22.9 0.0 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76900.1 - 1.1e-15 56.4 13.7 9.7e-06 25.3 0.0 6.2 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFA76900.1 - 1.2e-13 50.4 14.9 0.00068 19.8 0.6 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76900.1 - 1e-11 44.3 12.7 0.0011 18.5 0.2 6.3 4 2 3 7 7 7 3 TPR repeat TPR_14 PF13428.6 EFA76900.1 - 1e-11 44.6 3.3 0.0037 18.0 0.1 5.7 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76900.1 - 1.4e-11 44.9 4.7 0.00015 22.4 1.6 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.6 EFA76900.1 - 4.3e-09 36.6 6.0 0.016 15.5 0.1 5.7 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76900.1 - 3.4e-07 29.8 7.2 0.49 10.5 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76900.1 - 9.2e-07 29.3 12.5 0.0051 17.3 0.5 4.4 3 2 3 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76900.1 - 3.8e-06 26.7 10.0 0.06 13.6 0.0 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFA76900.1 - 1.4e-05 25.1 0.2 0.21 11.7 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA76900.1 - 0.00016 21.8 2.4 0.037 14.2 0.0 3.0 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFA76900.1 - 0.00019 21.6 12.1 0.0053 17.0 1.3 4.3 3 1 2 5 5 5 2 Tetratricopeptide repeat ChAPs PF09295.10 EFA76900.1 - 0.0019 17.3 2.6 0.22 10.5 0.0 2.8 2 1 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) Cid2 PF09774.9 EFA76900.1 - 0.0031 18.0 1.4 1 9.8 1.4 2.8 1 1 0 1 1 1 1 Caffeine-induced death protein 2 CPSase_L_D3 PF02787.19 EFA76900.1 - 0.0045 17.3 0.6 0.19 12.1 0.2 2.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Retrotrans_gag PF03732.17 EFA76900.1 - 0.11 12.8 1.7 7.1 7.0 0.0 3.7 3 0 0 3 3 3 0 Retrotransposon gag protein BTAD PF03704.17 EFA76900.1 - 0.3 11.5 3.4 1.3 9.5 0.4 2.9 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 EFA76900.1 - 0.59 10.9 9.6 20 6.1 0.0 5.5 7 0 0 7 7 5 0 Tetratricopeptide repeat Kinesin PF00225.23 EFA76901.1 - 6.4e-96 321.2 2.1 6.4e-96 321.2 2.1 3.8 4 1 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EFA76901.1 - 3.2e-14 53.1 6.3 7.7e-14 51.9 0.1 3.8 3 0 0 3 3 3 1 Microtubule binding Acetyltransf_11 PF13720.6 EFA76901.1 - 0.29 11.6 1.3 58 4.3 0.4 3.8 2 1 2 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Snf7 PF03357.21 EFA76902.1 - 3.2e-15 56.2 14.4 3.2e-15 56.2 14.4 1.4 1 1 1 2 2 2 1 Snf7 Ist1 PF03398.14 EFA76902.1 - 7.8e-06 25.9 5.8 1.2e-05 25.3 5.8 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway SAS4 PF15460.6 EFA76902.1 - 0.009 16.1 0.3 0.009 16.1 0.3 2.6 2 1 1 3 3 3 1 Something about silencing, SAS, complex subunit 4 AdoHcyase PF05221.17 EFA76903.1 - 2.2e-134 447.3 0.0 2.4e-74 250.2 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EFA76903.1 - 1.1e-84 282.5 3.3 1.6e-84 281.9 3.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFA76903.1 - 3.1e-07 29.9 0.1 7.5e-07 28.7 0.1 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFA76903.1 - 0.0057 16.2 0.1 0.0089 15.6 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EFA76903.1 - 0.021 15.1 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain ELFV_dehydrog PF00208.21 EFA76903.1 - 0.027 14.2 0.2 0.042 13.6 0.2 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Stealth_CR3 PF17102.5 EFA76904.1 - 0.055 13.4 0.4 0.21 11.5 0.2 1.9 2 0 0 2 2 2 0 Stealth protein CR3, conserved region 3 TPR_2 PF07719.17 EFA76905.1 - 5.4e-24 82.3 39.6 0.028 14.5 0.0 18.0 19 0 0 19 19 19 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFA76905.1 - 1e-17 63.1 38.5 0.053 13.4 0.1 15.1 15 0 0 15 15 15 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76905.1 - 2.7e-15 55.2 34.3 0.19 12.0 0.1 14.8 15 0 0 15 15 15 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFA76905.1 - 1.1e-14 53.9 9.1 1.9 9.5 0.0 14.3 16 1 2 18 18 17 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76905.1 - 2.1e-14 53.8 28.7 0.006 17.1 0.0 12.7 12 2 2 14 14 12 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76905.1 - 2.3e-14 53.8 11.6 0.033 14.8 0.0 10.4 11 2 0 11 11 11 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76905.1 - 4.9e-12 46.0 53.4 0.056 13.7 0.0 15.0 14 4 2 17 17 17 6 Tetratricopeptide repeat TPR_17 PF13431.6 EFA76905.1 - 6e-08 32.5 29.7 0.44 11.0 0.0 13.9 16 0 0 16 16 15 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76905.1 - 1.2e-07 31.3 19.6 0.19 11.5 0.2 9.9 11 0 0 11 11 11 2 TPR repeat TPR_6 PF13174.6 EFA76905.1 - 2.8e-07 30.7 29.5 0.056 14.1 0.0 11.9 13 0 0 13 13 11 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76905.1 - 8.8e-06 25.4 27.3 0.089 12.9 0.0 10.0 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFA76905.1 - 7.2e-05 22.5 14.7 0.88 9.5 0.0 8.6 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_4 PF07721.14 EFA76905.1 - 0.048 14.3 0.0 81 4.3 0.0 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76906.1 - 8.5e-07 28.6 0.3 0.005 16.5 0.0 2.6 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.17 EFA76906.1 - 1.3e-06 28.1 0.1 0.00025 20.9 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA76906.1 - 3.4e-06 26.6 0.0 0.0019 17.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76906.1 - 0.0003 20.6 0.0 7.2 6.9 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76906.1 - 0.00067 19.7 0.1 0.097 12.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF627 PF04781.12 EFA76906.1 - 0.00095 19.2 0.4 0.075 13.0 0.1 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF627) ANAPC3 PF12895.7 EFA76906.1 - 0.0024 18.1 0.5 0.0047 17.1 0.1 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFA76906.1 - 0.0042 17.4 0.0 0.1 12.9 0.0 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA76906.1 - 0.0077 16.9 0.0 0.1 13.3 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76906.1 - 0.015 15.8 0.0 2.7 8.6 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA76906.1 - 0.073 13.9 0.0 4.7 8.3 0.0 2.9 2 2 1 3 3 3 0 Tetratricopeptide repeat DnaJ_CXXCXGXG PF00684.19 EFA76907.1 - 0.002 18.4 24.1 0.031 14.7 22.2 3.1 1 1 1 2 2 2 2 DnaJ central domain Anti-TRAP PF15777.5 EFA76907.1 - 0.0028 17.6 19.7 0.0061 16.5 4.2 3.2 1 1 2 3 3 3 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 EFA76907.1 - 0.52 10.5 18.3 24 5.2 3.8 4.8 2 2 1 3 3 3 0 Family of unknown function (DUF5351) DUF2076 PF09849.9 EFA76907.1 - 0.56 10.2 5.0 0.64 10.0 5.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Ank_2 PF12796.7 EFA76908.1 - 4.2e-18 65.7 9.1 0.00054 20.5 0.0 6.0 3 1 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA76908.1 - 2.4e-11 43.9 9.1 0.0094 16.5 0.3 7.6 5 3 3 8 8 8 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA76908.1 - 3.3e-08 33.6 1.4 0.8 10.1 0.1 5.7 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA76908.1 - 7.4e-08 32.1 7.9 11 6.9 0.0 9.1 8 1 1 9 9 9 1 Ankyrin repeat Ank PF00023.30 EFA76908.1 - 0.1 13.1 1.4 10 6.8 0.0 4.1 4 1 0 4 4 4 0 Ankyrin repeat TFIIE_alpha PF02002.17 EFA76909.1 - 5.5e-12 45.5 4.4 5.5e-12 45.5 4.4 2.3 2 0 0 2 2 2 1 TFIIE alpha subunit Rrf2 PF02082.20 EFA76909.1 - 0.0037 17.6 0.1 0.013 15.9 0.1 1.9 1 0 0 1 1 1 1 Transcriptional regulator Alph_Pro_TM PF09608.10 EFA76909.1 - 0.077 12.8 0.3 0.13 12.0 0.3 1.3 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) Zn-ribbon_8 PF09723.10 EFA76909.1 - 0.081 13.1 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-C4_ClpX PF06689.13 EFA76911.1 - 0.0036 17.2 1.9 0.0061 16.4 1.7 1.6 1 1 0 1 1 1 1 ClpX C4-type zinc finger NMD3 PF04981.13 EFA76911.1 - 0.0046 16.5 0.0 0.0053 16.3 0.0 1.1 1 0 0 1 1 1 1 NMD3 family PhnA_Zn_Ribbon PF08274.12 EFA76911.1 - 0.028 14.4 1.1 0.051 13.5 1.1 1.4 1 1 0 1 1 1 0 PhnA Zinc-Ribbon zinc_ribbon_10 PF10058.9 EFA76911.1 - 0.11 12.2 2.6 8.4 6.2 0.0 3.1 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Mucin PF01456.17 EFA76912.1 - 2.9 7.9 35.1 0.66 10.0 11.0 3.4 3 0 0 3 3 3 0 Mucin-like glycoprotein CBS PF00571.28 EFA76915.1 - 4.8e-32 110.2 1.9 6.1e-11 42.6 0.0 4.2 4 0 0 4 4 4 4 CBS domain Borrelia_lipo_1 PF05714.11 EFA76915.1 - 0.055 13.2 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein SNAP PF14938.6 EFA76916.1 - 6.5e-109 363.7 24.2 7.3e-109 363.5 24.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFA76916.1 - 7.4e-08 32.6 17.1 0.00012 22.2 2.1 3.3 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA76916.1 - 1.6e-06 28.3 16.3 0.2 12.3 0.3 5.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA76916.1 - 9.3e-06 25.2 4.1 1.5e-05 24.5 4.1 1.3 1 0 0 1 1 1 1 MalT-like TPR region TPR_7 PF13176.6 EFA76916.1 - 0.00033 20.5 11.6 0.059 13.4 0.1 5.7 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76916.1 - 0.0013 19.2 16.9 0.58 10.7 1.4 4.7 3 2 2 5 5 4 3 Tetratricopeptide repeat DHR-2 PF06920.13 EFA76916.1 - 0.0036 16.0 1.9 0.0036 16.0 1.9 2.1 1 1 1 2 2 2 1 Dock homology region 2 TPR_16 PF13432.6 EFA76916.1 - 0.0048 17.5 17.3 0.087 13.5 1.8 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat Spatacsin_C PF14649.6 EFA76916.1 - 0.0056 15.8 1.0 0.0056 15.8 1.0 2.8 1 1 2 3 3 3 1 Spatacsin C-terminus TPR_14 PF13428.6 EFA76916.1 - 0.0065 17.2 14.2 0.61 11.1 0.1 5.2 2 2 2 5 5 5 1 Tetratricopeptide repeat RPN7 PF10602.9 EFA76916.1 - 0.023 14.4 7.4 0.012 15.3 2.2 2.3 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_8 PF13181.6 EFA76916.1 - 0.024 14.8 0.2 0.024 14.8 0.2 5.6 4 1 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76916.1 - 0.034 14.3 28.6 0.6 10.4 0.1 6.0 6 1 1 7 7 7 0 Tetratricopeptide repeat DUF2225 PF09986.9 EFA76916.1 - 0.35 10.6 11.8 0.47 10.1 3.0 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) ANAPC3 PF12895.7 EFA76916.1 - 0.44 10.8 15.3 0.51 10.6 0.4 3.7 2 2 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFA76916.1 - 0.45 10.4 11.7 4 7.4 0.1 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat SH3BP5 PF05276.14 EFA76916.1 - 3.5 7.3 10.8 1.2 8.9 4.0 2.5 1 1 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) Kelch_6 PF13964.6 EFA76917.1 - 1.3e-07 31.7 0.7 0.35 11.2 0.1 4.0 2 1 1 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA76917.1 - 1.3e-06 28.4 6.5 1.3e-06 28.4 6.5 2.8 3 1 0 3 3 3 1 B-box zinc finger Kelch_4 PF13418.6 EFA76917.1 - 2.5e-06 27.4 2.6 0.0083 16.1 0.0 4.1 4 1 1 5 5 4 2 Galactose oxidase, central domain zf-RING_5 PF14634.6 EFA76917.1 - 3.4e-05 23.7 11.6 3.4e-05 23.7 11.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFA76917.1 - 7.6e-05 22.8 16.0 7.6e-05 22.8 16.0 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EFA76917.1 - 0.00068 19.5 5.2 0.00068 19.5 5.2 3.1 3 0 0 3 3 3 1 zf-RING of BARD1-type protein Kelch_5 PF13854.6 EFA76917.1 - 0.001 19.0 4.4 0.055 13.5 0.3 3.6 4 0 0 4 4 4 1 Kelch motif zf-RING_UBOX PF13445.6 EFA76917.1 - 0.0043 17.0 13.2 0.0043 17.0 13.2 2.6 2 0 0 2 2 2 1 RING-type zinc-finger Kelch_1 PF01344.25 EFA76917.1 - 0.0051 16.4 0.3 4.3 7.0 0.0 3.4 4 0 0 4 4 4 2 Kelch motif zf-C3HC4 PF00097.25 EFA76917.1 - 0.0066 16.3 13.8 0.0066 16.3 13.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Phasin PF05597.11 EFA76917.1 - 0.26 11.3 1.6 1 9.4 1.2 2.1 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) zf-RING_2 PF13639.6 EFA76917.1 - 0.62 10.4 26.2 0.059 13.7 12.7 2.4 2 0 0 2 2 2 0 Ring finger domain Methyltransf_16 PF10294.9 EFA76918.1 - 1.8e-24 86.4 0.0 2.3e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFA76918.1 - 2.4e-10 40.5 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA76918.1 - 3.6e-07 30.8 0.2 7.2e-07 29.9 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA76918.1 - 5.1e-07 30.3 0.0 1.2e-06 29.2 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA76918.1 - 1.6e-06 28.0 0.0 2.5e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA76918.1 - 4.6e-06 27.2 0.0 8.6e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA76918.1 - 1.9e-05 24.2 0.0 3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 EFA76918.1 - 4.3e-05 23.0 0.1 7e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB RrnaAD PF00398.20 EFA76918.1 - 0.00047 19.3 0.0 0.00073 18.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DNA_methylase PF00145.17 EFA76918.1 - 0.00056 19.3 0.7 0.00096 18.6 0.1 1.7 2 0 0 2 2 2 1 C-5 cytosine-specific DNA methylase MTS PF05175.14 EFA76918.1 - 0.00079 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFA76918.1 - 0.0016 18.4 0.0 0.0033 17.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0146 PF03686.13 EFA76918.1 - 0.021 14.7 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) AtpR PF12966.7 EFA76918.1 - 0.17 12.3 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 N-ATPase, AtpR subunit SdrD_B PF17210.3 EFA76919.1 - 7.4e-15 55.1 9.5 0.00014 22.1 0.4 3.5 3 0 0 3 3 3 3 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA76919.1 - 4e-08 33.4 2.1 0.038 14.2 0.2 4.1 3 1 0 3 3 3 2 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA76919.1 - 2.2e-05 24.7 0.9 0.005 17.1 0.1 3.4 3 0 0 3 3 3 1 Prealbumin-like fold domain fn3_3 PF14686.6 EFA76919.1 - 0.0015 18.2 2.2 0.47 10.3 0.0 3.8 3 0 0 3 3 3 1 Polysaccharide lyase family 4, domain II CarbopepD_reg_2 PF13715.6 EFA76919.1 - 0.028 14.4 0.4 0.37 10.8 0.1 3.0 2 1 1 3 3 3 0 CarboxypepD_reg-like domain Big_1 PF02369.16 EFA76919.1 - 0.11 12.5 1.8 17 5.5 1.4 4.1 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 EFA76919.1 - 0.12 12.8 0.1 0.49 10.7 0.0 2.1 1 1 1 2 2 2 0 Invasin, domain 3 DUF2012 PF09430.10 EFA76919.1 - 0.17 12.0 0.0 0.51 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) SdrD_B PF17210.3 EFA76920.1 - 7.9e-12 45.4 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA76920.1 - 0.0077 16.5 0.0 0.038 14.3 0.0 2.0 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain RGM_N PF06535.12 EFA76925.1 - 0.021 15.1 0.0 0.025 14.8 0.0 1.1 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus GST_C PF00043.25 EFA76927.1 - 1e-08 35.3 0.0 1.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA76927.1 - 2.4e-07 30.9 0.0 2.9e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA76927.1 - 2.2e-05 24.4 0.0 4.4e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Chlam_PMP PF02415.17 EFA76928.1 - 0.6 10.7 5.4 0.52 10.9 0.5 3.7 2 0 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pkinase PF00069.25 EFA76929.1 - 3.5e-51 174.1 0.4 9.9e-51 172.6 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA76929.1 - 2.3e-50 171.3 0.0 3.7e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RA PF00788.23 EFA76929.1 - 0.019 15.6 0.0 0.079 13.6 0.0 2.1 1 1 0 1 1 1 0 Ras association (RalGDS/AF-6) domain APH PF01636.23 EFA76929.1 - 0.063 13.2 0.0 0.24 11.3 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family UPF0184 PF03670.13 EFA76930.1 - 0.046 14.1 5.7 0.064 13.6 3.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) Pur_ac_phosph_N PF16656.5 EFA76932.1 - 2.2e-20 73.0 1.5 2.2e-20 73.0 1.5 1.8 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFA76932.1 - 1.8e-18 67.1 0.2 5.5e-18 65.6 0.2 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 EFA76932.1 - 1.1e-16 62.0 2.8 1.1e-16 62.0 2.8 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA76932.1 - 0.077 13.2 0.0 0.16 12.1 0.0 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Methyltransf_25 PF13649.6 EFA76934.1 - 4.4e-21 75.4 0.0 8.5e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA76934.1 - 9.9e-20 70.9 0.0 2.6e-19 69.5 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EFA76934.1 - 4.9e-18 65.6 0.0 8.4e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA76934.1 - 1.1e-11 44.8 0.0 1.6e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA76934.1 - 9.6e-09 35.3 0.0 1.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EFA76934.1 - 2.1e-07 30.9 0.0 1.1e-06 28.5 0.0 1.9 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_12 PF08242.12 EFA76934.1 - 7.1e-07 29.9 0.0 1.2e-06 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA76934.1 - 0.0037 16.8 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFA76934.1 - 0.058 12.8 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 EFA76934.1 - 0.18 10.9 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFA76935.1 - 2.8e-19 69.6 0.0 6.3e-19 68.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA76935.1 - 6.5e-17 62.0 0.0 1.1e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA76935.1 - 9.1e-17 61.2 0.0 2.3e-16 59.9 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFA76935.1 - 1.4e-11 44.4 0.0 2e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA76935.1 - 1.9e-06 27.8 0.0 3.7e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA76935.1 - 8.8e-06 26.4 0.0 1.4e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFA76935.1 - 0.016 15.0 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 EFA76935.1 - 0.067 12.9 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_29 PF03141.16 EFA76935.1 - 0.086 11.4 0.0 0.1 11.1 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PseudoU_synth_1 PF01416.20 EFA76936.1 - 9e-34 116.2 0.0 8.3e-27 93.8 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase Endotoxin_N PF03945.14 EFA76938.1 - 7.3e-54 182.8 3.4 1.2e-53 182.2 3.4 1.3 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Endotoxin_C PF03944.14 EFA76938.1 - 0.003 17.9 0.0 0.0086 16.4 0.0 1.8 1 0 0 1 1 1 1 delta endotoxin AAA_29 PF13555.6 EFA76938.1 - 0.31 10.8 1.6 1.8 8.4 0.2 2.8 3 0 0 3 3 3 0 P-loop containing region of AAA domain Hexapep PF00132.24 EFA76939.1 - 3.8e-15 54.9 13.4 2.6e-05 23.8 0.1 4.4 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFA76939.1 - 6.5e-08 32.2 12.0 0.00054 19.7 0.5 4.1 3 1 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EFA76939.1 - 5.8e-06 25.5 2.4 0.0017 17.4 0.1 2.4 2 1 1 3 3 3 2 L-fucokinase ADH_zinc_N PF00107.26 EFA76940.1 - 1.1e-11 44.8 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA76940.1 - 1.1e-06 28.5 0.1 2e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Acyltransferase PF01553.21 EFA76941.1 - 0.00063 19.4 0.3 0.0045 16.6 0.1 2.2 2 1 0 2 2 2 1 Acyltransferase DUF4227 PF14004.6 EFA76941.1 - 0.045 13.7 4.9 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) Pep_deformylase PF01327.21 EFA76944.1 - 4.1e-15 55.7 1.1 1.2e-08 34.7 0.0 2.5 1 1 1 2 2 2 2 Polypeptide deformylase PseudoU_synth_2 PF00849.22 EFA76944.1 - 2.9e-14 53.4 0.0 9.1e-14 51.9 0.0 1.9 1 0 0 1 1 1 1 RNA pseudouridylate synthase FAD_binding_3 PF01494.19 EFA76945.1 - 1.3e-21 77.2 0.1 4.3e-20 72.3 0.1 2.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFA76945.1 - 4.6e-05 22.8 0.2 0.0066 15.7 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFA76945.1 - 0.00015 21.9 0.1 0.00034 20.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 EFA76945.1 - 0.025 13.9 0.0 0.057 12.8 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.14 EFA76945.1 - 0.048 12.4 0.1 0.084 11.6 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EFA76945.1 - 0.095 13.3 0.0 3.1 8.4 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EFA76945.1 - 0.12 12.0 0.1 0.34 10.6 0.1 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DAO PF01266.24 EFA76945.1 - 0.21 11.1 0.2 0.43 10.1 0.2 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase TPR_1 PF00515.28 EFA76946.1 - 1.1e-11 44.0 0.2 1.4e-07 31.0 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA76946.1 - 1.9e-09 36.9 0.0 4.7e-06 26.3 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA76946.1 - 3.3e-06 26.9 0.1 0.0019 18.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA76946.1 - 4.2e-05 23.3 0.0 0.00047 20.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA76946.1 - 9.4e-05 22.6 0.0 0.0004 20.6 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA76946.1 - 0.0097 16.1 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 PB1 PF00564.24 EFA76946.1 - 0.018 15.0 0.2 0.041 13.8 0.2 1.6 1 0 0 1 1 1 0 PB1 domain TPR_10 PF13374.6 EFA76946.1 - 0.047 13.6 0.0 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA76946.1 - 0.049 14.1 0.0 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76946.1 - 0.072 12.8 0.0 0.53 10.0 0.0 2.5 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 EFA76946.1 - 0.16 12.4 0.0 10 6.8 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat FWWh PF14922.6 EFA76947.1 - 0.048 13.6 0.2 0.053 13.5 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function Phage_int_SAM_5 PF13102.6 EFA76947.1 - 0.052 13.9 0.5 0.058 13.7 0.5 1.1 1 0 0 1 1 1 0 Phage integrase SAM-like domain AAA_2 PF07724.14 EFA76948.1 - 3.2e-49 167.3 0.0 1.1e-47 162.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFA76948.1 - 6e-35 119.3 1.7 6e-35 119.3 1.7 2.5 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EFA76948.1 - 5.2e-26 90.5 0.3 5.2e-26 90.5 0.3 2.8 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EFA76948.1 - 5.7e-24 85.0 0.0 1e-12 48.6 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFA76948.1 - 5.2e-15 55.7 0.1 3.1e-09 36.9 0.0 3.3 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA76948.1 - 2.2e-11 44.4 1.6 3.7e-05 24.2 0.1 4.5 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFA76948.1 - 1.4e-08 35.1 2.5 0.0085 16.4 0.2 5.1 2 2 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EFA76948.1 - 1.3e-06 28.2 0.0 0.0008 19.2 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 EFA76948.1 - 6.9e-06 25.6 0.0 0.019 14.4 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 EFA76948.1 - 2e-05 24.2 0.0 0.09 12.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFA76948.1 - 3.3e-05 23.4 0.0 0.42 10.0 0.0 3.3 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EFA76948.1 - 4e-05 23.7 0.0 0.056 13.5 0.0 3.6 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EFA76948.1 - 8.5e-05 22.4 0.0 0.18 11.5 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Roc PF08477.13 EFA76948.1 - 0.00029 21.1 0.0 1.7 8.9 0.0 2.9 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EFA76948.1 - 0.00038 20.8 0.0 2.7 8.4 0.0 3.5 3 0 0 3 3 2 2 RNA helicase AAA_18 PF13238.6 EFA76948.1 - 0.00048 20.7 3.1 0.37 11.3 0.1 3.8 3 2 0 3 3 2 2 AAA domain RuvB_N PF05496.12 EFA76948.1 - 0.00098 18.9 1.5 1.4 8.6 0.0 3.7 3 1 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_23 PF13476.6 EFA76948.1 - 0.0012 19.4 11.9 2.1 8.8 8.8 4.1 4 0 0 4 4 3 1 AAA domain TsaE PF02367.17 EFA76948.1 - 0.0013 18.8 0.0 2.3 8.2 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFA76948.1 - 0.0015 18.5 0.0 0.32 10.9 0.0 3.0 3 0 0 3 3 2 1 NACHT domain AAA_24 PF13479.6 EFA76948.1 - 0.0017 18.2 0.0 0.28 10.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EFA76948.1 - 0.0017 18.3 7.3 4 7.3 0.1 4.6 3 1 0 4 4 4 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EFA76948.1 - 0.0025 17.7 1.8 2.6 7.9 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_28 PF13521.6 EFA76948.1 - 0.0073 16.6 0.0 7 6.9 0.0 3.2 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 EFA76948.1 - 0.011 14.9 0.1 1 8.5 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 EFA76948.1 - 0.013 15.9 0.0 2 8.7 0.0 3.7 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.6 EFA76948.1 - 0.014 15.5 0.0 6.1 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EFA76948.1 - 0.017 14.9 0.0 0.52 10.1 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SRP54 PF00448.22 EFA76948.1 - 0.025 14.2 0.0 2.9 7.5 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_3 PF07726.11 EFA76948.1 - 0.03 14.2 0.0 20 5.1 0.0 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFA76948.1 - 0.036 13.8 0.0 15 5.4 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain ResIII PF04851.15 EFA76948.1 - 0.049 13.6 0.1 24 4.8 0.0 3.9 5 0 0 5 5 4 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 EFA76948.1 - 0.064 12.8 0.0 3.5 7.1 0.0 2.9 3 0 0 3 3 2 0 AAA domain ABC_tran PF00005.27 EFA76948.1 - 0.084 13.4 1.3 13 6.3 0.0 3.3 3 0 0 3 3 3 0 ABC transporter PduV-EutP PF10662.9 EFA76948.1 - 0.13 12.0 0.1 3.3 7.5 0.0 2.7 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation PPR_3 PF13812.6 EFA76949.1 - 0.00011 22.3 0.5 0.0061 16.6 0.1 3.1 3 1 0 3 3 3 1 Pentatricopeptide repeat domain Holin_BhlA PF10960.8 EFA76949.1 - 0.37 10.8 3.9 5.6 7.0 3.9 2.4 1 1 0 1 1 1 0 BhlA holin family Ntox8 PF15545.6 EFA76950.1 - 3.7e-10 39.8 0.5 7.8e-10 38.7 0.5 1.6 1 0 0 1 1 1 1 Bacterial toxin 8 HSP20 PF00011.21 EFA76952.1 - 1.4e-21 76.5 0.2 2.4e-21 75.8 0.2 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA76952.1 - 2.8e-09 36.4 0.0 4.7e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA FKBP26_C PF18046.1 EFA76952.1 - 0.007 16.4 0.4 2.9 8.1 0.1 2.4 2 0 0 2 2 2 2 FKBP26_C-terminal CS PF04969.16 EFA76952.1 - 0.0079 17.2 0.4 0.015 16.3 0.4 1.6 1 0 0 1 1 1 1 CS domain FMP23 PF17315.2 EFA76952.1 - 0.029 14.5 0.8 0.047 13.9 0.8 1.3 1 0 0 1 1 1 0 Found in mitochondrial proteome DUF2807 PF10988.8 EFA76952.1 - 0.084 12.7 0.9 0.8 9.5 0.2 2.0 1 1 1 2 2 2 0 Putative auto-transporter adhesin, head GIN domain RRM_1 PF00076.22 EFA76953.1 - 2.6e-12 46.4 0.0 4.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA76953.1 - 0.052 13.2 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FmiP_Thoc5 PF09766.9 EFA76953.1 - 1.2 8.3 7.5 19 4.4 0.0 2.1 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 DUF4637 PF15470.6 EFA76953.1 - 2.9 7.6 9.0 1.4 8.7 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) GST_N PF02798.20 EFA76955.1 - 7.7e-12 45.4 0.0 1.5e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA76955.1 - 1.9e-09 37.6 0.1 3.5e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA76955.1 - 6e-09 36.0 0.1 1.5e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA76955.1 - 1.8e-08 34.6 0.0 4.9e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA76955.1 - 5.7e-07 29.7 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA76955.1 - 8e-05 22.6 0.1 0.00059 19.8 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain ACP_PD PF04336.12 EFA76955.1 - 0.014 15.8 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase Glutaredoxin PF00462.24 EFA76955.1 - 0.069 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin Ank_2 PF12796.7 EFA76956.1 - 0.0036 17.8 0.1 0.29 11.8 0.0 3.6 4 1 0 4 4 4 1 Ankyrin repeats (3 copies) Hpt PF01627.23 EFA76957.1 - 2.8e-09 37.1 0.1 5.3e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 Hpt domain DUF572 PF04502.13 EFA76957.1 - 0.031 13.9 19.0 0.035 13.7 19.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 EFA76957.1 - 0.3 9.6 23.4 0.34 9.4 23.4 1.1 1 0 0 1 1 1 0 Utp14 protein DUF1043 PF06295.12 EFA76957.1 - 1.6 8.8 16.7 0.86 9.6 0.1 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF1043) DUF2678 PF10856.8 EFA76960.1 - 7.9e-07 29.0 0.3 1.5e-06 28.2 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) MFS_3 PF05977.13 EFA76960.1 - 0.16 10.3 0.6 0.23 9.8 0.6 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector Sox_N PF12444.8 EFA76960.1 - 0.67 11.1 3.7 2.3 9.4 3.7 1.9 1 1 0 1 1 1 0 Sox developmental protein N terminal TMF_DNA_bd PF12329.8 EFA76961.1 - 0.15 12.1 0.9 0.56 10.2 0.9 2.0 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding OrfB_Zn_ribbon PF07282.11 EFA76961.1 - 0.25 11.3 9.9 3 7.8 0.9 2.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 EFA76961.1 - 0.39 10.9 7.3 19 5.5 1.6 3.6 2 1 2 4 4 4 0 Zinc ribbon domain Ribosomal_L37ae PF01780.19 EFA76961.1 - 1 9.5 4.6 3.5 7.8 0.4 2.5 2 0 0 2 2 2 0 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EFA76961.1 - 3.2 7.8 17.0 0.59 10.1 4.1 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Pkinase_Tyr PF07714.17 EFA76962.1 - 6.6e-68 228.8 0.0 1e-67 228.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA76962.1 - 4.6e-55 186.8 0.0 9.7e-55 185.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EFA76962.1 - 2.3e-11 43.6 0.0 7.7e-11 41.9 0.0 1.9 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 EFA76962.1 - 0.00029 20.9 0.0 0.0011 18.9 0.1 1.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFA76962.1 - 0.0011 17.9 0.0 0.0011 17.9 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Cbl_N2 PF02761.14 EFA76962.1 - 0.021 15.5 0.1 0.064 14.0 0.1 1.9 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain Mem_trans PF03547.18 EFA76962.1 - 0.034 12.5 0.1 0.036 12.5 0.1 1.1 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 EFA76962.1 - 0.16 10.7 6.6 0.23 10.2 6.6 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFA76962.1 - 0.33 10.1 6.8 0.54 9.4 6.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EFA76962.1 - 2.2 6.7 12.1 3.3 6.2 12.1 1.1 1 0 0 1 1 1 0 Macoilin family DUF2417 PF10329.9 EFA76963.1 - 0.72 9.2 7.8 0.99 8.8 7.8 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF2070 PF09843.9 EFA76963.1 - 2.3 6.4 11.3 2.8 6.1 11.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2304 PF10066.9 EFA76963.1 - 4.2 7.6 11.1 3.3 8.0 9.9 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Peptidase_U4 PF03419.13 EFA76963.1 - 7.3 5.8 10.8 9.9 5.4 10.8 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Glycos_transf_1 PF00534.20 EFA76965.1 - 6.4e-08 32.3 0.0 1.1e-06 28.4 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA76965.1 - 4.5e-05 23.9 0.0 0.00011 22.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 NOA36 PF06524.12 EFA76966.1 - 0.00013 21.4 11.7 0.00024 20.5 11.7 1.4 1 0 0 1 1 1 1 NOA36 protein DUF2457 PF10446.9 EFA76966.1 - 0.0046 16.2 15.6 0.0067 15.6 15.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) RPN2_C PF18004.1 EFA76966.1 - 0.0067 16.4 6.5 0.01 15.8 6.5 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Roughex PF06020.11 EFA76966.1 - 0.0077 15.4 10.7 0.0099 15.0 10.7 1.1 1 0 0 1 1 1 1 Drosophila roughex protein SDA1 PF05285.12 EFA76966.1 - 0.0077 15.7 11.0 0.0096 15.4 11.0 1.1 1 0 0 1 1 1 1 SDA1 CNDH2_C PF16858.5 EFA76966.1 - 0.0089 15.9 4.9 0.011 15.7 4.9 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term PPP4R2 PF09184.11 EFA76966.1 - 0.015 14.9 13.3 0.019 14.6 13.3 1.1 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 EFA76966.1 - 0.016 14.5 9.5 0.02 14.3 9.5 1.1 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 EFA76966.1 - 0.027 13.3 3.7 0.036 12.8 3.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_Ag35 PF03286.14 EFA76966.1 - 0.047 13.5 13.1 0.07 12.9 13.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 EFA76966.1 - 0.063 11.6 12.2 0.083 11.2 12.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFA76966.1 - 0.12 10.6 16.2 0.15 10.3 16.2 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RanBP PF00641.18 EFA76966.1 - 0.15 11.4 5.3 0.25 10.7 5.3 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others TLP-20 PF06088.11 EFA76966.1 - 0.29 11.0 5.7 0.52 10.2 5.7 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Nucleoporin_FG PF13634.6 EFA76966.1 - 0.32 11.9 19.1 0.37 11.7 13.4 3.4 3 1 0 3 3 3 0 Nucleoporin FG repeat region DNA_pol_phi PF04931.13 EFA76966.1 - 0.67 8.0 24.2 0.87 7.6 24.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi PTPRCAP PF15713.5 EFA76966.1 - 0.89 9.8 15.5 1.5 9.1 15.5 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Cwf_Cwc_15 PF04889.12 EFA76966.1 - 0.95 9.2 19.3 1.3 8.8 19.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Astro_capsid_p PF12226.8 EFA76966.1 - 1.1 8.4 16.3 1.5 7.9 16.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF913 PF06025.12 EFA76966.1 - 1.3 7.9 4.0 1.9 7.4 4.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIF_alpha PF05793.12 EFA76966.1 - 1.5 7.3 21.2 2.2 6.8 21.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPR3 PF03666.13 EFA76966.1 - 1.6 7.5 6.1 2 7.1 6.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TRAP_alpha PF03896.16 EFA76966.1 - 6.6 5.9 11.6 9.4 5.3 11.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit HPD PF05044.12 EFA76967.1 - 0.018 14.9 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Homeo-prospero domain DUF4024 PF13216.6 EFA76969.1 - 0.15 12.0 0.0 4.8 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) bZIP_2 PF07716.15 EFA76971.1 - 0.021 14.9 0.1 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 Basic region leucine zipper HPD PF05044.12 EFA76972.1 - 0.03 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Homeo-prospero domain TPR_17 PF13431.6 EFA76973.1 - 8.6e-131 417.3 17.5 8.7e-11 41.4 0.0 14.0 13 1 1 14 14 14 13 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76973.1 - 1.5e-19 69.4 31.2 0.038 13.7 0.1 12.7 12 1 1 13 13 13 7 TPR repeat Anth_Ig PF05587.13 EFA76973.1 - 2.2e-07 31.1 14.1 15 5.9 0.0 10.0 11 0 0 11 11 11 1 Anthrax receptor extracellular domain DUF1153 PF06627.11 EFA76973.1 - 8.5e-05 22.6 0.2 45 4.3 0.0 8.2 12 0 0 12 12 12 0 Protein of unknown function (DUF1153) DUF1344 PF07076.11 EFA76973.1 - 9.7e-05 22.2 24.5 7.1 6.6 0.0 10.2 12 0 0 12 12 12 1 Protein of unknown function (DUF1344) Ntox46 PF15538.6 EFA76973.1 - 0.00048 20.1 1.4 46 4.0 0.0 5.9 3 3 4 8 8 8 0 Bacterial toxin 46 NleF_casp_inhib PF16809.5 EFA76973.1 - 0.027 14.4 9.4 31 4.4 0.0 7.6 7 3 2 10 10 10 0 NleF caspase inhibitor PDH_E1_M PF17831.1 EFA76973.1 - 0.033 13.7 0.4 1.2 8.6 0.0 3.4 3 1 1 4 4 4 0 Pyruvate dehydrogenase E1 component middle domain Actin PF00022.19 EFA76974.1 - 1e-22 80.3 0.0 1.1e-22 80.3 0.0 1.0 1 0 0 1 1 1 1 Actin Glyco_hydro_30 PF02055.16 EFA76975.1 - 2e-41 142.1 1.5 3.1e-41 141.5 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Actin PF00022.19 EFA76975.1 - 2e-37 128.8 0.1 2.8e-37 128.3 0.1 1.1 1 0 0 1 1 1 1 Actin Glyco_hydro_59 PF02057.15 EFA76975.1 - 2.4e-11 43.4 0.1 5.4e-11 42.3 0.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 59 MreB_Mbl PF06723.13 EFA76975.1 - 0.23 10.2 0.0 0.34 9.7 0.0 1.1 1 0 0 1 1 1 0 MreB/Mbl protein 2OG-FeII_Oxy_3 PF13640.6 EFA76977.1 - 7.2e-10 39.6 0.0 1.1e-09 39.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EFA76977.1 - 0.002 18.5 0.0 0.0055 17.1 0.0 1.7 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Cobl PF09469.10 EFA76977.1 - 0.097 12.9 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Cordon-bleu ubiquitin-like domain Abhydrolase_6 PF12697.7 EFA76978.1 - 5.7e-09 36.9 0.0 7.1e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA76978.1 - 2.7e-05 23.9 0.3 5.3e-05 23.0 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold CsbD PF05532.12 EFA76979.1 - 8.4e-07 28.8 1.7 1.5e-06 28.0 1.7 1.3 1 0 0 1 1 1 1 CsbD-like Presenilin PF01080.17 EFA76980.1 - 1.2 7.8 13.9 1.5 7.5 13.9 1.3 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 EFA76980.1 - 2.1 6.5 47.7 2.9 6.1 47.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CPSF100_C PF13299.6 EFA76980.1 - 2.3 8.4 6.3 5.4 7.2 6.3 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spt4 PF06093.13 EFA76981.1 - 1.7e-25 88.9 0.1 2e-25 88.7 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger DGF-1_5 PF11038.8 EFA76981.1 - 0.17 11.2 0.0 0.17 11.2 0.0 1.0 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 VPS28 PF03997.12 EFA76982.1 - 2.1e-67 226.5 4.7 2.5e-67 226.2 4.7 1.1 1 0 0 1 1 1 1 VPS28 protein DUF5560 PF17715.1 EFA76982.1 - 0.087 12.3 4.2 0.13 11.7 4.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5560) PIG-Y PF15159.6 EFA76983.1 - 6.6e-19 68.6 8.5 1.1e-18 67.9 8.5 1.4 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Plasmodium_Vir PF05795.11 EFA76983.1 - 0.0024 17.4 1.7 0.0025 17.3 1.7 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein FAM60A PF15396.6 EFA76983.1 - 0.028 14.4 2.6 0.041 13.9 2.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A GET2 PF08690.10 EFA76983.1 - 0.043 13.5 15.1 0.13 11.9 15.1 1.7 1 1 0 1 1 1 0 GET complex subunit GET2 TFIIA PF03153.13 EFA76983.1 - 0.062 13.3 23.9 0.077 13.0 23.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MAT1 PF06391.13 EFA76983.1 - 0.099 12.5 8.0 0.14 12.0 8.0 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ALMT PF11744.8 EFA76983.1 - 0.11 11.4 1.8 0.13 11.0 1.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 EFA76983.1 - 0.15 11.1 3.1 0.19 10.7 3.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein Ferlin_C PF16165.5 EFA76983.1 - 0.19 11.7 0.1 0.19 11.7 0.1 1.6 2 0 0 2 2 1 0 Ferlin C-terminus DUF2076 PF09849.9 EFA76983.1 - 0.29 11.2 19.7 0.46 10.5 19.7 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MPM1 PF17234.2 EFA76983.1 - 0.49 10.6 10.8 0.78 10.0 10.8 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 XRN_M PF17846.1 EFA76983.1 - 2.1 7.2 9.0 2.9 6.7 9.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF1387 PF07139.11 EFA76983.1 - 2.6 7.7 13.4 3.2 7.4 13.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Peptidase_M56 PF05569.11 EFA76983.1 - 3 7.0 7.1 0.69 9.1 0.1 2.2 1 1 1 2 2 2 0 BlaR1 peptidase M56 Auts2 PF15336.6 EFA76983.1 - 3 7.9 12.1 0.09 12.9 4.8 1.8 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein Macoilin PF09726.9 EFA76983.1 - 3.6 6.0 12.8 4.5 5.7 12.8 1.2 1 0 0 1 1 1 0 Macoilin family DUF2207 PF09972.9 EFA76983.1 - 4.1 6.0 5.7 0.65 8.7 0.4 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) MDFI PF15316.6 EFA76983.1 - 4.5 7.3 8.8 1.3 9.1 3.2 2.1 2 0 0 2 2 2 0 MyoD family inhibitor SKA1 PF07160.12 EFA76983.1 - 4.9 6.9 14.6 7.4 6.3 14.6 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 TMEM164 PF14808.6 EFA76984.1 - 0.00012 21.5 14.1 0.0043 16.4 14.1 2.8 1 1 0 1 1 1 1 TMEM164 family DUF3139 PF11337.8 EFA76984.1 - 6.7 7.4 7.1 3 8.6 0.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) RFC1 PF08519.12 EFA76985.1 - 2.3e-41 141.5 0.0 2.3e-41 141.5 0.0 2.4 3 0 0 3 3 3 1 Replication factor RFC1 C terminal domain AAA PF00004.29 EFA76985.1 - 4.5e-12 46.5 0.0 1.4e-11 45.0 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 EFA76985.1 - 2.2e-11 44.0 0.0 9.7e-11 41.9 0.0 2.3 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFA76985.1 - 0.00089 19.2 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.12 EFA76985.1 - 0.0013 18.5 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFA76985.1 - 0.46 11.0 0.0 0.46 11.0 0.0 3.6 3 1 1 4 4 4 0 AAA domain DLIC PF05783.11 EFA76986.1 - 0.08 11.8 0.2 0.12 11.2 0.2 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Oxidored_q2 PF00420.24 EFA76986.1 - 0.25 11.0 6.5 0.36 10.5 1.3 2.8 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L TPR_17 PF13431.6 EFA76987.1 - 2.4e-71 231.1 11.2 1.1e-10 41.1 0.2 7.4 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFA76987.1 - 2.5e-16 59.0 13.7 0.037 13.7 0.1 7.3 7 0 0 7 7 7 7 TPR repeat Anth_Ig PF05587.13 EFA76987.1 - 0.00022 21.5 7.8 14 6.0 0.0 5.6 6 0 0 6 6 6 2 Anthrax receptor extracellular domain NleF_casp_inhib PF16809.5 EFA76987.1 - 0.00096 19.1 5.1 3.7 7.4 0.0 4.6 4 1 1 5 5 5 2 NleF caspase inhibitor DUF1153 PF06627.11 EFA76987.1 - 0.092 12.9 0.1 1e+02 3.1 0.0 4.7 6 0 0 6 6 6 0 Protein of unknown function (DUF1153) CsbD PF05532.12 EFA76989.1 - 8.8e-05 22.3 0.5 0.00014 21.7 0.4 1.4 1 1 0 1 1 1 1 CsbD-like VPS28 PF03997.12 EFA76989.1 - 0.011 15.4 0.4 0.011 15.4 0.4 2.0 2 1 1 3 3 3 0 VPS28 protein DUF4065 PF13274.6 EFA76989.1 - 0.81 10.6 7.1 0.16 12.9 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) DUF2956 PF11169.8 EFA76989.1 - 2.4 8.4 6.2 0.28 11.4 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) BNIP2 PF12496.8 EFA76989.1 - 4.1 7.9 9.3 1.1 9.7 4.3 2.1 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Na_H_Exchanger PF00999.21 EFA76990.1 - 6e-49 166.8 27.2 6.9e-49 166.6 27.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SR-25 PF10500.9 EFA76992.1 - 0.34 10.5 12.0 0.61 9.6 12.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 EFA76992.1 - 0.5 8.7 4.3 0.72 8.2 4.3 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) VWA PF00092.28 EFA76993.1 - 3.2e-21 76.4 0.3 8.3e-21 75.0 0.1 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA76993.1 - 8.3e-14 52.1 0.0 2.8e-13 50.4 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain NB-ARC PF00931.22 EFA76993.1 - 0.013 14.7 0.2 0.026 13.7 0.2 1.4 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 EFA76993.1 - 0.018 15.1 0.2 0.058 13.5 0.2 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA76993.1 - 0.047 13.2 0.2 7.7 6.0 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA76993.1 - 0.052 13.5 1.1 2 8.3 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase VWA_3 PF13768.6 EFA76993.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain YedD PF13987.6 EFA76993.1 - 0.17 11.7 0.3 1.6 8.6 0.2 2.5 2 1 1 3 3 3 0 YedD-like protein GST_C_3 PF14497.6 EFA76996.1 - 1.2e-19 70.3 0.0 2.3e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA76996.1 - 1e-05 25.7 0.0 1.7e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA76996.1 - 0.00012 22.2 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA76996.1 - 0.033 14.2 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Coronavirus_5 PF05528.11 EFA76996.1 - 0.14 12.1 0.0 1.3 9.1 0.0 2.3 2 1 0 2 2 2 0 Coronavirus gene 5 protein FAD-oxidase_C PF02913.19 EFA76997.1 - 3.2e-54 184.2 0.0 5.9e-54 183.3 0.0 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFA76997.1 - 2e-37 128.0 0.0 3.6e-37 127.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EFA76998.1 - 3.8e-48 164.9 0.0 5.9e-48 164.3 0.0 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA76998.1 - 7.7e-11 42.1 0.0 3.1e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EFA76998.1 - 0.0004 19.7 0.0 0.00067 19.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFA76998.1 - 0.0099 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFA76998.1 - 0.014 14.5 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EFA76998.1 - 0.025 15.2 0.1 0.057 14.0 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFA76998.1 - 0.24 10.0 0.1 0.34 9.6 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein TIG PF01833.24 EFA76999.1 - 1.5e-08 34.6 14.5 8.8e-05 22.5 6.0 3.7 2 1 1 3 3 3 2 IPT/TIG domain I-EGF_1 PF18372.1 EFA76999.1 - 0.00038 20.5 3.6 0.0011 19.0 3.6 1.8 1 0 0 1 1 1 1 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 EFA76999.1 - 0.0028 18.0 7.5 0.0079 16.5 7.5 1.8 1 0 0 1 1 1 1 EGF-like domain CLU_N PF15044.6 EFA76999.1 - 3.3 8.1 4.9 13 6.3 0.1 3.3 3 0 0 3 3 3 0 Mitochondrial function, CLU-N-term DUF229 PF02995.17 EFA77000.1 - 5.7e-38 130.8 1.5 1.8e-37 129.1 1.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 EFA77000.1 - 1.6e-06 27.8 0.1 0.0089 15.4 0.0 2.6 1 1 1 2 2 2 2 Sulfatase Ufd2P_core PF10408.9 EFA77001.1 - 1.9e-117 393.4 16.9 2.5e-103 346.9 12.1 2.3 2 0 0 2 2 2 2 Ubiquitin elongating factor core U-box PF04564.15 EFA77001.1 - 2.9e-30 104.2 1.7 1.2e-29 102.2 1.0 2.6 2 0 0 2 2 2 1 U-box domain Mucin PF01456.17 EFA77001.1 - 0.43 10.6 24.9 0.88 9.6 24.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Sporozoite_P67 PF05642.11 EFA77001.1 - 0.72 7.9 10.6 1.2 7.2 10.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FSA_C PF10479.9 EFA77001.1 - 1.9 6.5 10.0 3 5.9 10.0 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 EFA77001.1 - 5.4 7.0 16.2 14 5.7 16.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) EMG1 PF03587.14 EFA77002.1 - 1.4e-69 233.6 0.0 1.1e-67 227.5 0.0 2.2 1 1 0 1 1 1 1 EMG1/NEP1 methyltransferase DUF1863 PF08937.11 EFA77002.1 - 0.068 13.5 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Peptidase_C1 PF00112.23 EFA77003.1 - 7.3e-51 173.3 0.9 1.3e-50 172.5 0.9 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA77003.1 - 6.7e-14 52.1 2.7 1.1e-13 51.3 2.7 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) KLRAQ PF10205.9 EFA77004.1 - 0.16 12.2 7.8 0.053 13.8 2.7 2.8 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein HALZ PF02183.18 EFA77004.1 - 1.7 8.9 5.5 3.7 7.9 0.3 2.4 1 1 1 2 2 2 0 Homeobox associated leucine zipper GST_N PF02798.20 EFA77006.1 - 7e-10 39.1 0.0 2.2e-09 37.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA77006.1 - 3.5e-08 33.5 0.1 7.9e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Mucin PF01456.17 EFA77006.1 - 0.071 13.1 25.5 0.12 12.3 25.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein GST_C_2 PF13410.6 EFA77006.1 - 0.12 12.5 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Jagunal PF07086.12 EFA77006.1 - 0.2 11.7 3.2 0.39 10.8 2.9 1.6 1 1 1 2 2 2 0 Jagunal, ER re-organisation during oogenesis SDA1 PF05285.12 EFA77006.1 - 0.29 10.5 7.9 0.41 10.0 7.9 1.1 1 0 0 1 1 1 0 SDA1 SSP160 PF06933.11 EFA77006.1 - 0.48 8.6 19.7 0.73 8.0 19.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 EFA77006.1 - 1.2 9.1 15.3 2.3 8.2 15.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) LacAB_rpiB PF02502.18 EFA77008.1 - 0.09 12.8 3.9 0.38 10.7 1.4 2.3 1 1 1 2 2 2 0 Ribose/Galactose Isomerase SOG2 PF10428.9 EFA77008.1 - 0.46 9.6 18.3 0.62 9.2 18.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein EBP50_C PF09007.11 EFA77008.1 - 2.8 9.0 12.1 4.7 8.2 12.1 1.3 1 0 0 1 1 1 0 EBP50, C-terminal MBD_C PF14048.6 EFA77008.1 - 5.1 7.9 7.3 5.9 7.7 6.2 1.7 1 1 0 1 1 1 0 C-terminal domain of methyl-CpG binding protein 2 and 3 AMP-binding PF00501.28 EFA77009.1 - 1.3e-49 169.0 0.0 1.8e-49 168.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFA77009.1 - 2.1e-49 168.0 0.0 9e-49 166.0 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein Epimerase PF01370.21 EFA77009.1 - 2.7e-07 30.3 0.0 4.9e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA77009.1 - 7e-06 25.3 0.0 1.8e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EFA77009.1 - 0.0024 18.2 0.5 0.0085 16.4 0.2 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFA77009.1 - 0.0027 18.7 0.0 0.006 17.5 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1091 PF06477.13 EFA77009.1 - 0.03 14.8 0.0 0.26 11.8 0.0 2.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) C1_2 PF03107.16 EFA77009.1 - 0.044 14.1 7.4 0.13 12.6 7.4 1.8 1 0 0 1 1 1 0 C1 domain ZZ PF00569.17 EFA77009.1 - 0.38 10.6 6.4 0.78 9.6 6.4 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Tnp_zf-ribbon_2 PF13842.6 EFA77009.1 - 2.9 8.8 6.5 6.2 7.7 6.5 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon SecA_DEAD PF07517.14 EFA77010.1 - 1.3e-06 27.9 0.0 1.3e-06 27.9 0.0 3.2 4 0 0 4 4 4 1 SecA DEAD-like domain HU-CCDC81_bac_2 PF18175.1 EFA77010.1 - 0.64 9.9 4.2 21 5.1 0.1 4.1 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Helicase_C PF00271.31 EFA77010.1 - 0.76 10.1 9.1 0.67 10.3 1.2 3.9 3 0 0 3 3 3 0 Helicase conserved C-terminal domain Thioredoxin PF00085.20 EFA77013.1 - 5.6e-45 151.6 1.4 2.6e-22 78.7 0.0 3.8 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EFA77013.1 - 8.7e-35 120.3 9.9 6.1e-29 101.2 5.4 3.5 3 1 1 4 4 4 2 Thioredoxin-like domain Calsequestrin PF01216.17 EFA77013.1 - 2.4e-11 43.3 0.4 7.6e-11 41.7 0.1 1.8 2 0 0 2 2 2 1 Calsequestrin OST3_OST6 PF04756.13 EFA77013.1 - 8.8e-08 31.8 1.2 1.8e-05 24.3 0.0 3.4 3 0 0 3 3 3 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFA77013.1 - 2.6e-05 24.6 1.0 0.14 12.6 0.1 3.5 2 2 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 EFA77013.1 - 0.00062 19.7 0.2 0.064 13.2 0.0 3.2 2 1 1 3 3 3 1 AhpC/TSA family ERp29_N PF07912.13 EFA77013.1 - 0.035 14.3 1.8 1.4 9.0 0.0 3.4 4 1 0 4 4 4 0 ERp29, N-terminal domain Thioredoxin_5 PF13743.6 EFA77013.1 - 0.04 13.6 0.1 3.2 7.4 0.0 2.9 1 1 1 2 2 2 0 Thioredoxin Thioredoxin_7 PF13899.6 EFA77013.1 - 0.058 13.6 0.2 14 5.9 0.0 3.3 3 1 0 3 3 3 0 Thioredoxin-like Thioredoxin_8 PF13905.6 EFA77013.1 - 0.69 10.3 5.6 7.8 6.9 0.1 4.4 4 1 1 5 5 5 0 Thioredoxin-like YmcE_antitoxin PF15939.5 EFA77014.1 - 0.0035 17.5 0.1 0.0044 17.1 0.1 1.2 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system SecA_DEAD PF07517.14 EFA77015.1 - 3.8e-09 36.3 1.8 1.5e-08 34.3 0.0 2.9 3 0 0 3 3 3 1 SecA DEAD-like domain Helicase_C PF00271.31 EFA77015.1 - 0.0062 16.9 0.9 0.13 12.6 0.4 3.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DNA_repr_REX1B PF14966.6 EFA77015.1 - 0.37 11.5 4.4 27 5.5 0.1 3.9 2 0 0 2 2 2 0 DNA repair REX1-B MMR_HSR1 PF01926.23 EFA77017.1 - 0.001 19.1 0.0 0.0036 17.4 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFA77017.1 - 0.0049 17.4 0.1 0.014 15.9 0.1 1.8 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EFA77017.1 - 0.024 15.2 0.2 0.024 15.2 0.2 3.0 3 1 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EFA77017.1 - 0.025 14.3 0.2 0.093 12.5 0.2 2.0 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EFA77017.1 - 0.035 13.7 0.7 0.069 12.7 0.7 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFA77017.1 - 0.071 13.0 0.5 0.26 11.2 0.4 2.0 2 1 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 EFA77017.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF3638 PF12340.8 EFA77018.1 - 6.3e-42 143.4 0.1 1e-41 142.7 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) Pox_H7 PF04787.12 EFA77019.1 - 0.038 14.5 0.1 0.12 12.9 0.1 1.9 1 0 0 1 1 1 0 Late protein H7 CBM32 PF18344.1 EFA77019.1 - 0.083 12.8 0.1 0.33 10.9 0.1 2.0 1 0 0 1 1 1 0 Carbohydrate binding module family 32 ATP-synt_ab_C PF00306.27 EFA77020.1 - 0.15 12.4 8.8 3.1 8.1 0.4 4.8 3 2 1 4 4 4 0 ATP synthase alpha/beta chain, C terminal domain Helicase_C PF00271.31 EFA77021.1 - 0.019 15.3 1.4 0.019 15.3 1.4 2.7 2 1 0 2 2 2 0 Helicase conserved C-terminal domain NAD_binding_4 PF07993.12 EFA77022.1 - 3.9e-52 177.0 0.0 7.7e-52 176.0 0.0 1.5 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EFA77022.1 - 2.6e-45 154.8 0.0 3.8e-45 154.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EFA77022.1 - 2.9e-09 36.8 0.0 6.2e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA77022.1 - 1.3e-06 27.6 0.0 6.3e-06 25.4 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EFA77022.1 - 1.7e-05 25.1 0.2 4.9e-05 23.6 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 EFA77022.1 - 0.0077 15.7 0.3 0.029 13.7 0.1 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NTP_transf_8 PF12281.8 EFA77022.1 - 0.16 12.0 0.0 4.8 7.1 0.0 2.2 2 0 0 2 2 2 0 Nucleotidyltransferase C1_2 PF03107.16 EFA77023.1 - 0.00064 20.0 7.2 0.0012 19.1 7.2 1.5 1 0 0 1 1 1 1 C1 domain ZZ PF00569.17 EFA77023.1 - 0.0045 16.8 6.6 0.0073 16.1 6.6 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Tnp_zf-ribbon_2 PF13842.6 EFA77023.1 - 0.15 12.9 6.4 0.28 12.0 6.4 1.5 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon zf-C4_ClpX PF06689.13 EFA77023.1 - 0.5 10.3 6.9 0.13 12.2 1.4 2.3 1 1 1 2 2 2 0 ClpX C4-type zinc finger SET PF00856.28 EFA77024.1 - 7.2e-18 65.5 1.3 1.8e-17 64.3 0.1 2.2 2 0 0 2 2 2 1 SET domain TPR_2 PF07719.17 EFA77024.1 - 0.0026 17.8 2.7 0.09 12.9 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA77024.1 - 0.028 15.2 0.0 0.078 13.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Cript PF10235.9 EFA77024.1 - 0.22 12.1 4.3 0.11 13.0 0.4 2.5 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT DUF2740 PF10872.8 EFA77025.1 - 0.096 12.6 0.2 0.28 11.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) Patatin PF01734.22 EFA77025.1 - 2.5 8.2 10.2 10 6.2 10.2 1.8 1 1 0 1 1 1 0 Patatin-like phospholipase RIFIN PF02009.16 EFA77025.1 - 4.3 7.1 15.5 0.35 10.7 9.5 1.8 1 1 1 2 2 2 0 Rifin LicD PF04991.13 EFA77025.1 - 4.6 7.3 21.6 0.11 12.6 11.2 2.0 1 1 1 2 2 2 0 LicD family Glyco_hydro_31 PF01055.26 EFA77026.1 - 4.6e-145 484.2 9.6 5.8e-145 483.8 9.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFA77026.1 - 3.9e-24 84.7 1.5 2.7e-23 82.0 0.0 3.2 4 0 0 4 4 4 1 Galactose mutarotase-like DUF5110 PF17137.4 EFA77026.1 - 9.1e-08 32.3 0.3 2.1e-07 31.1 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) DUF2846 PF11008.8 EFA77026.1 - 0.064 13.3 0.4 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2846) Sen15 PF09631.10 EFA77027.1 - 2.9e-20 72.4 0.6 1.1e-19 70.5 0.6 2.0 1 0 0 1 1 1 1 Sen15 protein GATA PF00320.27 EFA77027.1 - 3.5e-14 52.1 5.7 8.7e-14 50.8 5.7 1.7 1 0 0 1 1 1 1 GATA zinc finger zinc_ribbon_9 PF14369.6 EFA77027.1 - 1.4 9.2 5.2 2.1 8.6 2.8 2.3 2 0 0 2 2 2 0 zinc-ribbon Kelch_6 PF13964.6 EFA77028.1 - 6.8e-11 42.0 4.1 0.00029 21.0 0.2 4.5 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA77028.1 - 6.9e-07 28.7 2.3 0.013 15.1 0.5 2.7 2 0 0 2 2 2 2 Kelch motif zf-B_box PF00643.24 EFA77028.1 - 0.0012 19.0 11.3 0.0012 19.0 11.3 2.3 2 0 0 2 2 2 1 B-box zinc finger Kelch_5 PF13854.6 EFA77028.1 - 0.0043 17.0 3.2 0.58 10.2 0.3 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EFA77028.1 - 0.24 11.4 5.8 1.7 8.7 0.1 3.4 2 1 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 EFA77029.1 - 1.5e-12 47.3 3.8 8.2e-05 22.7 0.1 5.4 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA77029.1 - 0.00073 19.6 10.8 0.00073 19.6 10.8 2.2 3 0 0 3 3 3 1 B-box zinc finger Kelch_1 PF01344.25 EFA77029.1 - 0.00091 18.8 4.2 0.61 9.7 0.1 3.5 4 0 0 4 4 4 2 Kelch motif BRCA-2_OB3 PF09104.10 EFA77029.1 - 0.19 11.4 2.1 1.1 8.9 0.1 2.3 2 0 0 2 2 2 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 LRV_FeS PF05484.11 EFA77029.1 - 0.24 11.4 0.1 0.24 11.4 0.1 2.3 2 0 0 2 2 2 0 LRV protein FeS4 cluster FYVE PF01363.21 EFA77029.1 - 0.41 10.8 4.6 0.25 11.5 2.0 2.0 2 0 0 2 2 2 0 FYVE zinc finger Kelch_5 PF13854.6 EFA77029.1 - 2.8 8.0 8.8 9.9 6.3 0.3 3.1 3 0 0 3 3 3 0 Kelch motif ATP_transf PF09830.9 EFA77030.1 - 3.1e-20 72.1 0.0 6.3e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4922 PF16269.5 EFA77030.1 - 0.00022 21.1 2.2 0.0039 17.0 2.2 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4922) Secretin_N_2 PF07655.13 EFA77030.1 - 1.4 9.5 24.6 1.2 9.8 1.6 3.2 3 0 0 3 3 3 0 Secretin N-terminal domain DUF4834 PF16118.5 EFA77030.1 - 4.9 8.2 6.6 10 7.2 2.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Arm PF00514.23 EFA77031.1 - 0.0007 19.5 0.8 0.093 12.8 0.0 3.5 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Ank_2 PF12796.7 EFA77032.1 - 8.7e-29 100.0 5.1 1.1e-06 29.1 0.2 5.7 3 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77032.1 - 1.5e-24 86.0 5.2 0.00067 20.2 0.0 9.4 5 3 4 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77032.1 - 4.3e-19 66.6 5.7 0.52 11.0 0.0 12.6 15 0 0 15 15 15 3 Ankyrin repeat Ank_5 PF13857.6 EFA77032.1 - 2.1e-18 66.1 5.0 1 9.8 0.0 10.8 6 4 5 11 11 11 5 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA77032.1 - 0.004 17.1 24.0 0.65 10.0 1.0 6.5 2 2 4 6 6 6 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA77032.1 - 0.016 15.6 0.9 72 4.1 0.0 6.2 8 0 0 8 8 8 0 Ankyrin repeat LURAP PF14854.6 EFA77032.1 - 0.056 13.4 10.7 0.38 10.7 0.1 5.7 4 2 2 7 7 7 0 Leucine rich adaptor protein DUF249 PF03158.13 EFA77032.1 - 0.13 12.0 17.7 0.58 9.8 0.4 5.2 3 3 2 5 5 5 0 Multigene family 530 protein Ank_2 PF12796.7 EFA77033.1 - 1.7e-14 54.1 1.5 9e-05 23.0 0.4 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA77033.1 - 2.2e-10 39.9 2.4 0.3 11.8 0.0 7.5 8 0 0 8 8 8 2 Ankyrin repeat Ank_4 PF13637.6 EFA77033.1 - 5.9e-08 33.1 1.8 5 7.8 0.1 6.3 4 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77033.1 - 7e-07 29.4 0.7 25 5.4 0.0 6.3 3 1 2 6 6 6 1 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA77033.1 - 0.0072 16.1 5.2 0.13 11.9 0.3 3.5 2 1 1 3 3 3 1 Multigene family 530 protein TctC PF03401.14 EFA77034.1 - 0.097 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor Prenyltransf PF01255.19 EFA77035.1 - 4.7e-26 91.7 3.8 4.7e-26 91.7 3.8 2.6 2 2 0 2 2 2 1 Putative undecaprenyl diphosphate synthase DUF885 PF05960.11 EFA77035.1 - 0.0061 16.3 2.3 0.0061 16.3 2.3 2.4 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF885) DUF3883 PF13020.6 EFA77036.1 - 0.04 13.9 0.1 0.064 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) TIG PF01833.24 EFA77037.1 - 1.6e-120 393.5 316.7 1.9e-08 34.2 8.2 30.4 31 0 0 31 31 31 29 IPT/TIG domain DNase_II PF03265.15 EFA77037.1 - 1.8e-42 145.8 6.9 3.4e-42 144.9 6.9 1.5 1 0 0 1 1 1 1 Deoxyribonuclease II Qn_am_d_aIII PF09099.10 EFA77037.1 - 5.4e-10 39.5 15.0 1.7 9.1 0.0 14.5 19 0 0 19 19 19 1 Quinohemoprotein amine dehydrogenase, alpha subunit domain III DUF844 PF05815.11 EFA77037.1 - 0.19 10.9 3.5 0.79 8.9 0.5 2.3 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF844) TIG PF01833.24 EFA77038.1 - 5e-87 286.1 160.8 3.5e-15 55.9 3.1 30.2 17 2 8 25 25 25 13 IPT/TIG domain RHD_dimer PF16179.5 EFA77038.1 - 0.22 11.6 2.0 3.2 7.8 0.0 4.2 4 0 0 4 4 4 0 Rel homology dimerisation domain TIG PF01833.24 EFA77039.1 - 2.3e-50 168.6 94.6 3.8e-13 49.3 0.3 13.3 12 2 1 13 13 13 12 IPT/TIG domain DNase_II PF03265.15 EFA77039.1 - 4.2e-32 111.7 8.0 7.2e-30 104.4 8.0 2.6 1 1 0 1 1 1 1 Deoxyribonuclease II IL6Ra-bind PF09240.10 EFA77039.1 - 0.87 10.1 3.3 3.7 8.1 0.4 3.3 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding TIG PF01833.24 EFA77040.1 - 3.7e-130 424.3 504.6 4.1e-15 55.6 2.6 37.9 30 2 1 33 33 33 28 IPT/TIG domain Presenilin PF01080.17 EFA77041.1 - 0.0047 15.7 9.0 0.0055 15.5 9.0 1.2 1 0 0 1 1 1 1 Presenilin RR_TM4-6 PF06459.12 EFA77041.1 - 0.021 14.7 15.4 0.028 14.3 15.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 EFA77041.1 - 0.023 15.0 12.2 0.029 14.7 12.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CCSAP PF15748.5 EFA77041.1 - 0.023 14.9 17.7 0.034 14.3 17.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF1682 PF07946.14 EFA77041.1 - 0.044 13.0 17.8 0.053 12.7 17.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) NPR3 PF03666.13 EFA77041.1 - 0.052 12.3 15.3 0.072 11.9 15.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FapA PF03961.13 EFA77041.1 - 0.077 11.6 14.9 0.096 11.3 14.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A RNA_pol_Rpc4 PF05132.14 EFA77041.1 - 0.16 12.4 11.8 0.29 11.6 11.8 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 ALMT PF11744.8 EFA77041.1 - 0.58 8.9 8.5 0.84 8.4 8.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 EFA77041.1 - 0.73 8.0 18.8 0.93 7.7 18.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 EFA77041.1 - 0.81 8.8 8.2 1.2 8.2 8.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 EFA77041.1 - 0.95 8.3 4.7 1.1 8.2 4.7 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Hid1 PF12722.7 EFA77041.1 - 0.98 7.5 11.0 1.2 7.2 11.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RP-C_C PF11800.8 EFA77041.1 - 1.2 9.2 9.1 2.3 8.3 9.1 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Serinc PF03348.15 EFA77041.1 - 1.6 7.6 5.0 1.7 7.5 5.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Macoilin PF09726.9 EFA77041.1 - 2.5 6.6 20.2 3.2 6.2 20.2 1.1 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 EFA77041.1 - 5.3 6.3 11.1 6.3 6.1 11.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MDM10 PF12519.8 EFA77041.1 - 5.9 5.6 13.0 8.1 5.2 13.0 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PTPRCAP PF15713.5 EFA77041.1 - 6.9 6.9 15.2 2.1 8.6 12.1 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated TIG PF01833.24 EFA77043.1 - 2.3e-53 178.2 103.2 1.5e-13 50.6 0.4 12.9 12 1 1 13 13 13 12 IPT/TIG domain DNase_II PF03265.15 EFA77043.1 - 1.9e-32 112.9 3.9 6.1e-30 104.6 3.9 2.7 1 1 0 1 1 1 1 Deoxyribonuclease II TIG PF01833.24 EFA77044.1 - 1e-162 528.7 412.3 3.7e-15 55.8 2.6 35.8 32 3 2 35 35 35 30 IPT/TIG domain RHD_dimer PF16179.5 EFA77044.1 - 0.15 12.1 0.7 4.6 7.3 0.0 3.8 3 0 0 3 3 3 0 Rel homology dimerisation domain Omega-toxin PF06357.11 EFA77044.1 - 0.51 10.2 3.4 4.2 7.2 0.7 2.9 2 0 0 2 2 2 0 Omega-atracotoxin DUF3439 PF11921.8 EFA77046.1 - 0.011 15.7 5.4 0.011 15.7 5.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DMPK_coil PF08826.10 EFA77046.1 - 0.062 13.4 11.2 0.12 12.4 10.3 2.0 1 1 1 2 2 2 0 DMPK coiled coil domain like Mucin PF01456.17 EFA77046.1 - 1.2 9.2 29.5 0.67 9.9 10.4 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein bZIP_1 PF00170.21 EFA77046.1 - 2.1 8.5 18.2 32 4.7 18.2 2.4 1 1 0 1 1 1 0 bZIP transcription factor Comm PF15957.5 EFA77046.1 - 3.2 8.1 5.1 1.2 9.5 1.0 2.4 2 0 0 2 2 2 0 Commissureless adh_short PF00106.25 EFA77047.1 - 9.8e-38 129.6 0.0 1.4e-37 129.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA77047.1 - 3.2e-22 79.2 0.0 4.5e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA77047.1 - 3.2e-08 33.7 0.2 4.7e-08 33.2 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA77047.1 - 7.2e-05 22.4 0.1 9.8e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFA77047.1 - 0.00018 20.7 0.1 0.00021 20.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EFA77047.1 - 0.00045 19.7 0.3 0.01 15.3 0.0 2.1 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Sacchrp_dh_NADP PF03435.18 EFA77047.1 - 0.016 15.5 0.3 0.023 14.9 0.3 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain C1q PF00386.21 EFA77047.1 - 0.036 14.3 0.1 0.069 13.4 0.1 1.4 1 0 0 1 1 1 0 C1q domain NAD_binding_10 PF13460.6 EFA77047.1 - 0.036 14.0 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding DUF2935 PF11155.8 EFA77047.1 - 0.16 12.3 0.2 12 6.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) PNRC PF15365.6 EFA77048.1 - 1e-08 34.8 5.3 1e-08 34.8 5.3 2.6 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator motif DUF2126 PF09899.9 EFA77048.1 - 0.32 9.0 2.8 0.38 8.8 2.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) AAA_6 PF12774.7 EFA77050.1 - 4.2e-136 453.2 0.0 2.6e-135 450.6 0.0 2.5 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFA77050.1 - 5e-114 381.5 10.8 5e-114 381.5 10.8 4.9 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 EFA77050.1 - 5.1e-102 342.3 13.0 5.1e-102 342.3 13.0 4.3 4 1 0 4 4 3 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 EFA77050.1 - 2.1e-73 246.1 0.0 2.1e-73 246.1 0.0 5.2 5 1 0 5 5 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 EFA77050.1 - 3e-71 239.8 0.0 3.4e-70 236.4 0.0 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFA77050.1 - 2.2e-50 171.6 6.3 1.7e-49 168.7 2.2 3.6 4 0 0 4 4 4 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 EFA77050.1 - 5.5e-44 149.8 0.0 1e-36 126.1 0.0 4.5 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 EFA77050.1 - 3.5e-43 148.0 15.4 8.3e-43 146.7 15.4 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 EFA77050.1 - 1.8e-39 135.2 0.0 1.1e-38 132.6 0.0 2.3 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFA77050.1 - 2.7e-34 118.1 0.0 2.9e-13 50.0 0.0 7.2 6 1 0 6 6 6 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EFA77050.1 - 3.9e-28 97.9 0.0 6.2e-27 94.1 0.0 3.3 3 0 0 3 3 1 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EFA77050.1 - 3.6e-20 72.3 0.0 2.1e-19 69.9 0.0 2.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EFA77050.1 - 8.6e-14 52.0 0.3 0.0013 19.0 0.0 6.8 6 0 0 6 6 5 3 AAA domain AAA PF00004.29 EFA77050.1 - 1.4e-12 48.2 0.0 0.0034 17.8 0.0 5.1 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA77050.1 - 9.2e-09 35.9 0.3 1 9.7 0.0 7.3 8 0 0 8 8 6 1 AAA ATPase domain AAA_33 PF13671.6 EFA77050.1 - 7.8e-08 32.6 1.1 0.61 10.2 0.0 5.2 5 0 0 5 5 4 2 AAA domain AAA_lid_1 PF17857.1 EFA77050.1 - 8.7e-08 32.3 0.0 3.4e-07 30.4 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain T2SSE PF00437.20 EFA77050.1 - 3.4e-05 23.0 0.0 0.14 11.2 0.0 3.0 3 0 0 3 3 2 2 Type II/IV secretion system protein Taxilin PF09728.9 EFA77050.1 - 5.5e-05 22.5 1.6 5.5e-05 22.5 1.6 4.5 5 0 0 5 5 4 1 Myosin-like coiled-coil protein AAA_30 PF13604.6 EFA77050.1 - 7.4e-05 22.5 0.1 5.9 6.6 0.0 4.1 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EFA77050.1 - 0.00011 22.8 1.3 19 5.8 0.0 5.8 5 0 0 5 5 5 0 AAA domain AAA_19 PF13245.6 EFA77050.1 - 0.00021 21.7 1.7 0.2 12.0 0.0 4.7 4 1 0 4 4 4 1 AAA domain PI3K_P85_iSH2 PF16454.5 EFA77050.1 - 0.0012 18.5 1.4 0.0012 18.5 1.4 5.0 4 0 0 4 4 3 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain IstB_IS21 PF01695.17 EFA77050.1 - 0.002 17.9 1.2 1.2 8.9 0.0 4.4 4 0 0 4 4 4 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFA77050.1 - 0.0022 17.4 2.5 0.74 9.2 0.0 3.6 5 0 0 5 5 3 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EFA77050.1 - 0.0041 16.8 0.0 19 5.1 0.0 3.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EFA77050.1 - 0.0056 16.4 0.0 18 5.0 0.0 4.6 4 0 0 4 4 4 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA77050.1 - 0.045 13.1 0.0 17 4.6 0.0 3.7 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_25 PF13481.6 EFA77050.1 - 0.058 13.0 0.0 0.38 10.3 0.0 2.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFA77050.1 - 0.059 13.8 0.3 1.4e+02 3.0 0.0 4.8 5 0 0 5 5 4 0 RNA helicase UPF0489 PF12640.7 EFA77050.1 - 0.13 12.4 0.9 0.54 10.5 0.9 2.0 1 0 0 1 1 1 0 UPF0489 domain MCM_N PF14551.6 EFA77050.1 - 0.16 12.5 1.7 0.86 10.2 0.0 3.2 3 0 0 3 3 1 0 MCM N-terminal domain Aldedh PF00171.22 EFA77051.1 - 4.3e-101 338.7 0.0 5.2e-101 338.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LPG_synthase_TM PF03706.13 EFA77052.1 - 0.0015 18.2 0.0 0.0017 17.9 0.0 1.1 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region PMT_4TMC PF16192.5 EFA77052.1 - 0.23 11.0 2.7 0.46 10.1 2.5 1.4 1 1 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase DDE_Tnp_4 PF13359.6 EFA77054.1 - 3.4e-07 30.1 0.8 0.014 15.0 0.1 2.4 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA77054.1 - 0.03 14.0 2.7 0.08 12.6 2.7 1.6 1 1 0 1 1 1 0 Transposase DDE domain Saf_2TM PF18303.1 EFA77054.1 - 0.087 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain TPR_17 PF13431.6 EFA77055.1 - 1.2e-297 940.0 37.2 9.7e-10 38.2 0.0 35.3 36 0 0 36 36 36 34 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77055.1 - 2.2e-41 139.3 70.9 0.016 14.9 0.3 26.6 29 0 0 29 29 29 15 TPR repeat NleF_casp_inhib PF16809.5 EFA77055.1 - 2.8e-14 53.3 26.9 3.5 7.5 0.0 19.4 15 6 10 25 25 25 3 NleF caspase inhibitor bPH_1 PF08000.11 EFA77055.1 - 4.5e-05 23.5 10.7 8.1 6.6 0.0 10.5 11 2 1 12 12 12 1 Bacterial PH domain Lyx_isomer PF07385.12 EFA77055.1 - 7.2e-05 22.1 14.5 29 3.8 0.0 14.7 8 6 10 22 22 22 0 D-lyxose isomerase Optomotor-blind PF11078.8 EFA77055.1 - 0.0054 17.3 0.0 89 3.7 0.0 4.3 4 0 0 4 4 4 0 Optomotor-blind protein N-terminal region Anth_Ig PF05587.13 EFA77055.1 - 0.0071 16.6 41.1 64 3.9 0.0 18.0 28 0 0 28 28 27 0 Anthrax receptor extracellular domain Ntox46 PF15538.6 EFA77055.1 - 0.016 15.2 4.4 49 3.9 0.0 7.5 7 3 5 12 12 12 0 Bacterial toxin 46 ImmE5 PF11480.8 EFA77055.1 - 0.025 15.1 0.0 1.9e+02 2.6 0.0 6.7 9 1 0 10 10 10 0 Colicin-E5 Imm protein Glyco_hydro_72 PF03198.14 EFA77055.1 - 0.053 12.8 9.5 3 7.0 0.0 7.2 5 3 2 9 9 9 0 Glucanosyltransferase TPR_19 PF14559.6 EFA77055.1 - 1 9.9 7.0 40 4.8 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat HTH_psq PF05225.16 EFA77056.1 - 0.0014 18.3 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_3 PF01381.22 EFA77056.1 - 0.0031 17.5 0.1 0.045 13.8 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.6 EFA77056.1 - 0.0034 17.3 0.2 0.0098 15.8 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EFA77056.1 - 0.0078 16.2 1.6 0.012 15.6 0.5 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 EFA77056.1 - 0.015 14.8 0.6 0.08 12.5 0.1 2.2 1 1 1 2 2 2 0 Sigma-70, region 4 HTH_24 PF13412.6 EFA77056.1 - 0.05 13.2 0.0 0.19 11.3 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding Trp_repressor PF01371.19 EFA77056.1 - 0.053 13.7 0.1 0.16 12.1 0.1 1.9 1 0 0 1 1 1 0 Trp repressor protein Histone_HNS PF00816.21 EFA77056.1 - 0.062 14.1 1.5 13 6.7 0.2 2.2 2 0 0 2 2 2 0 H-NS histone family HTH_26 PF13443.6 EFA77056.1 - 0.066 13.7 0.0 0.24 11.8 0.0 1.9 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain CENP-B_N PF04218.13 EFA77056.1 - 0.079 12.6 1.7 14 5.4 0.0 2.9 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain Phytochelatin PF05023.14 EFA77058.1 - 4.5e-78 261.3 0.0 5.2e-78 261.1 0.0 1.0 1 0 0 1 1 1 1 Phytochelatin synthase BTB PF00651.31 EFA77059.1 - 2.5e-17 63.1 1.4 9.9e-15 54.7 1.4 2.8 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EFA77059.1 - 7.2e-11 42.1 2.9 2.4e-09 37.2 0.3 2.7 2 0 0 2 2 2 2 BTB And C-terminal Kelch DUF3342 PF11822.8 EFA77059.1 - 0.048 13.9 1.3 5 7.4 0.2 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) Peptidase_S28 PF05577.12 EFA77060.1 - 2e-123 412.4 4.3 2.3e-123 412.2 4.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 EFA77060.1 - 6.1e-06 25.2 0.2 1.4e-05 24.0 0.1 1.5 2 0 0 2 2 2 1 PS-10 peptidase S37 GTP_EFTU PF00009.27 EFA77061.1 - 2.2e-52 177.4 0.0 3.6e-52 176.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFA77061.1 - 8.8e-33 113.0 0.0 2.2e-32 111.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFA77061.1 - 5.2e-12 46.0 1.3 1.4e-11 44.6 1.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFA77061.1 - 1.1e-06 28.6 0.1 2.4e-05 24.4 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFA77061.1 - 0.017 15.2 0.4 5.7 7.0 0.1 2.4 2 1 0 2 2 2 0 Dynamin family FeoB_N PF02421.18 EFA77061.1 - 0.11 12.0 0.3 1.8 8.1 0.1 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B GTP_EFTU_D4 PF14578.6 EFA77061.1 - 0.15 12.0 6.1 0.043 13.7 2.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Ank_2 PF12796.7 EFA77062.1 - 1.1e-08 35.5 0.1 1.8e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77062.1 - 2.4e-06 28.0 0.1 6.1e-06 26.7 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77062.1 - 9.3e-05 22.6 0.0 0.02 15.4 0.1 2.8 1 1 1 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EFA77062.1 - 0.00061 20.0 0.2 0.0018 18.6 0.2 1.8 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Plasmid_RAQPRD PF09686.10 EFA77062.1 - 0.089 13.0 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Ank PF00023.30 EFA77062.1 - 0.13 12.8 1.2 0.55 10.8 0.0 2.5 3 0 0 3 3 3 0 Ankyrin repeat DUF1635 PF07795.11 EFA77062.1 - 2.1 8.1 8.5 0.75 9.6 5.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) zf-CCCH_7 PF18586.1 EFA77062.1 - 3.5 8.0 6.4 1.8 8.9 1.9 2.5 2 1 1 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 DUF1874 PF08960.10 EFA77064.1 - 0.036 14.2 0.1 0.065 13.4 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1874) Ras PF00071.22 EFA77065.1 - 4e-64 215.1 0.7 4.6e-64 214.9 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA77065.1 - 1.5e-35 122.0 0.8 3.8e-35 120.7 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA77065.1 - 1.9e-16 60.0 0.2 2.3e-16 59.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA77065.1 - 1.6e-05 24.9 0.0 0.00014 21.9 0.0 2.0 1 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA77065.1 - 2.2e-05 24.4 0.6 0.15 12.0 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFA77065.1 - 2.6e-05 23.7 0.1 3e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFA77065.1 - 5.3e-05 22.8 0.6 0.00013 21.6 0.6 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EFA77065.1 - 0.00018 21.9 0.1 0.031 14.7 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EFA77065.1 - 0.00046 19.7 0.1 0.0007 19.1 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFA77065.1 - 0.0019 17.7 0.0 0.015 14.8 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_5 PF07728.14 EFA77065.1 - 0.025 14.6 0.1 0.076 13.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFA77065.1 - 0.032 14.5 0.0 0.088 13.1 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA77065.1 - 0.041 14.3 0.0 0.065 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFA77065.1 - 0.055 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EFA77065.1 - 0.068 12.7 0.1 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region LepB_N PF18640.1 EFA77065.1 - 0.078 12.6 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 LepB N-terminal domain TniB PF05621.11 EFA77065.1 - 0.096 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EFA77065.1 - 0.15 12.0 0.0 0.4 10.6 0.0 1.6 2 0 0 2 2 2 0 NACHT domain TRAP_alpha PF03896.16 EFA77066.1 - 2.6e-37 128.6 0.4 2.9e-37 128.4 0.4 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit TIM21 PF08294.11 EFA77066.1 - 0.13 12.1 0.0 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 TIM21 DUF4271 PF14093.6 EFA77066.1 - 3.3 7.5 6.7 0.2 11.5 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) F-box PF00646.33 EFA77067.1 - 0.071 13.0 0.6 0.26 11.2 0.1 2.2 2 0 0 2 2 2 0 F-box domain FNIP PF05725.12 EFA77068.1 - 3e-47 158.5 34.0 9.9e-14 51.2 2.8 7.6 4 2 3 8 8 8 6 FNIP Repeat Glyco_hydro_65C PF03633.15 EFA77068.1 - 0.092 12.7 1.6 55 3.8 0.0 4.7 5 0 0 5 5 5 0 Glycosyl hydrolase family 65, C-terminal domain Peptidase_M24 PF00557.24 EFA77069.1 - 9.5e-53 179.0 0.0 1.5e-52 178.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFA77069.1 - 7.8e-28 96.7 0.0 1.6e-27 95.7 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain RAP1 PF07218.11 EFA77070.1 - 2.7 6.2 10.3 3.5 5.8 10.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TMEM119 PF15724.5 EFA77070.1 - 7.6 6.5 10.0 11 6.0 10.0 1.1 1 0 0 1 1 1 0 TMEM119 family XRN_M PF17846.1 EFA77071.1 - 1.8e-113 379.8 5.8 1.8e-113 379.8 5.8 4.7 2 1 1 4 4 4 1 Xrn1 helical domain XRN_N PF03159.18 EFA77071.1 - 6.4e-95 317.2 0.1 6.4e-95 317.2 0.1 4.2 3 1 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus GTP_EFTU_D2 PF03144.25 EFA77072.1 - 0.00011 22.5 0.1 0.00014 22.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFA77072.1 - 0.0071 16.2 0.1 0.0084 16.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu domain 4 HTH_27 PF13463.6 EFA77072.1 - 0.1 13.1 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain Robl_LC7 PF03259.17 EFA77073.1 - 4.8e-17 61.5 0.0 5.3e-17 61.4 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 EFA77073.1 - 8.7e-05 22.4 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 DUF1506 PF07405.11 EFA77073.1 - 0.02 15.1 0.3 0.022 14.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1506) RRM_1 PF00076.22 EFA77074.1 - 1.5e-18 66.3 0.0 3.2e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA77074.1 - 0.0003 20.8 0.0 0.00078 19.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EFA77074.1 - 0.0045 16.6 0.0 0.007 16.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MMADHC PF10229.9 EFA77075.1 - 4.9e-24 85.5 0.0 6.2e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein GrpE PF01025.19 EFA77076.1 - 3e-49 166.9 3.5 4e-49 166.5 3.5 1.1 1 0 0 1 1 1 1 GrpE SPATA1_C PF15743.5 EFA77076.1 - 0.05 13.7 4.8 0.075 13.1 4.8 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Not3 PF04065.15 EFA77076.1 - 0.11 12.0 6.1 0.15 11.4 6.1 1.2 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Mad3_BUB1_I_2 PF17014.5 EFA77076.1 - 0.12 12.5 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein FAM76 PF16046.5 EFA77076.1 - 0.15 11.4 2.7 0.19 11.0 2.7 1.1 1 0 0 1 1 1 0 FAM76 protein FlaG PF03646.15 EFA77076.1 - 0.16 12.2 3.1 0.38 11.0 3.1 1.6 1 0 0 1 1 1 0 FlaG protein NBD_C PF17042.5 EFA77076.1 - 0.16 12.4 1.6 0.23 11.9 1.6 1.3 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain FDF PF09532.10 EFA77076.1 - 1.6 9.7 6.5 0.76 10.7 4.3 1.6 2 0 0 2 2 2 0 FDF domain FlxA PF14282.6 EFA77076.1 - 6.6 6.8 8.6 1.6 8.8 4.7 1.9 1 1 1 2 2 2 0 FlxA-like protein Alg6_Alg8 PF03155.15 EFA77077.1 - 5e-122 408.3 28.6 5e-122 408.3 28.6 1.9 1 1 1 2 2 2 2 ALG6, ALG8 glycosyltransferase family 7tm_1 PF00001.21 EFA77077.1 - 1.2 8.4 15.6 0.51 9.6 2.7 3.4 2 1 0 3 3 3 0 7 transmembrane receptor (rhodopsin family) 2OG-FeII_Oxy_3 PF13640.6 EFA77078.1 - 5.4e-06 27.2 0.2 1.4e-05 25.9 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EFA77078.1 - 0.0052 17.4 0.0 0.012 16.3 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zip PF02535.22 EFA77078.1 - 0.078 12.2 2.3 0.084 12.1 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter EndoU_bacteria PF14436.6 EFA77078.1 - 0.13 12.6 5.4 0.28 11.5 5.4 1.5 1 0 0 1 1 1 0 Bacterial EndoU nuclease EF-hand_1 PF00036.32 EFA77079.1 - 3.1e-14 51.3 1.5 0.00035 19.9 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFA77079.1 - 6.9e-13 48.9 0.2 7.7e-08 32.7 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA77079.1 - 1.6e-11 43.2 1.5 0.0017 18.1 0.2 4.1 3 1 1 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EFA77079.1 - 3e-09 36.6 2.4 2.6e-06 27.2 0.5 3.3 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 EFA77079.1 - 1.5e-05 25.2 0.1 0.021 15.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 EFA77079.1 - 0.0038 18.1 0.1 0.0057 17.5 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain DUF3232 PF11554.8 EFA77079.1 - 0.031 14.6 0.1 0.062 13.7 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3232) Caleosin PF05042.13 EFA77079.1 - 0.064 13.2 0.3 2.1 8.3 0.1 2.5 1 1 2 3 3 3 0 Caleosin related protein FumaraseC_C PF10415.9 EFA77079.1 - 0.14 12.6 0.4 5.5 7.5 0.1 2.6 2 0 0 2 2 2 0 Fumarase C C-terminus SRP54 PF00448.22 EFA77080.1 - 6.4e-52 176.0 1.4 6.4e-52 176.0 1.4 2.5 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EFA77080.1 - 5.6e-41 141.4 18.5 5.6e-41 141.4 18.5 2.1 1 1 1 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 EFA77080.1 - 1.1e-10 41.5 0.1 4.9e-10 39.5 0.1 2.2 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EFA77080.1 - 3.6e-06 26.2 0.0 7.5e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EFA77080.1 - 3.2e-05 23.7 0.1 6e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFA77080.1 - 0.00024 21.2 0.1 0.00024 21.2 0.1 2.8 2 2 0 2 2 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 EFA77080.1 - 0.00027 20.6 1.0 0.00086 18.9 1.0 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EFA77080.1 - 0.00054 19.9 0.1 0.22 11.4 0.0 2.8 1 1 0 2 2 2 1 NTPase AAA_22 PF13401.6 EFA77080.1 - 0.0044 17.3 0.0 0.018 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.6 EFA77080.1 - 0.0047 16.9 0.8 0.071 13.0 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA77080.1 - 0.0053 17.2 0.0 0.022 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Fer4_NifH PF00142.18 EFA77080.1 - 0.015 14.7 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family APS_kinase PF01583.20 EFA77080.1 - 0.055 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_28 PF13521.6 EFA77080.1 - 0.15 12.3 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFA77080.1 - 0.22 12.0 0.0 0.22 12.0 0.0 3.5 1 1 2 3 3 2 0 AAA domain SPOUT_MTase PF02590.17 EFA77080.1 - 0.88 9.5 0.0 0.88 9.5 0.0 2.9 4 1 0 4 4 3 0 Predicted SPOUT methyltransferase Roughex PF06020.11 EFA77080.1 - 2.5 7.1 16.0 3.9 6.5 16.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein NUDIX PF00293.28 EFA77081.1 - 1.7e-10 41.0 0.2 8e-10 38.9 0.2 1.8 1 1 0 1 1 1 1 NUDIX domain Ribosomal_S27e PF01667.17 EFA77082.1 - 5e-24 83.8 2.3 6.1e-24 83.5 2.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zinc_ribbon_4 PF13717.6 EFA77082.1 - 0.025 14.5 2.0 0.73 9.8 2.0 2.3 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_L50 PF10501.9 EFA77082.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal subunit 39S zf-CSL PF05207.13 EFA77082.1 - 0.51 10.1 3.2 0.91 9.3 3.2 1.5 1 1 0 1 1 1 0 CSL zinc finger TPR_17 PF13431.6 EFA77083.1 - 1.1e-09 38.0 0.2 2.7e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77083.1 - 0.0057 16.3 0.6 0.046 13.4 0.1 2.2 2 0 0 2 2 2 1 TPR repeat DUF1153 PF06627.11 EFA77083.1 - 0.1 12.7 0.0 2.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) ETC_C1_NDUFA4 PF04800.12 EFA77084.1 - 7.1e-26 90.3 0.0 1.1e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Methyltransf_25 PF13649.6 EFA77085.1 - 1.5e-09 38.5 0.0 3.8e-09 37.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA77085.1 - 3.8e-09 36.5 0.1 4.7e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA77085.1 - 2.3e-08 34.6 0.0 5.2e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFA77085.1 - 3.5e-07 29.8 0.0 5.2e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFA77085.1 - 5.4e-06 26.3 0.0 7.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77085.1 - 1.2e-05 26.0 1.4 1.9e-05 25.3 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain N6_N4_Mtase PF01555.18 EFA77085.1 - 2.4e-05 24.2 0.0 3.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 DNA methylase Methyltransf_18 PF12847.7 EFA77085.1 - 4.9e-05 23.3 0.2 9.3e-05 22.4 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFA77085.1 - 0.00011 22.2 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFA77085.1 - 0.00027 20.4 0.0 0.00044 19.8 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EFA77085.1 - 0.00053 19.5 0.0 0.00068 19.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 EFA77085.1 - 0.0016 18.0 0.9 0.0024 17.5 0.0 1.7 2 1 0 2 2 2 1 Histone methylation protein DOT1 MTS PF05175.14 EFA77085.1 - 0.0019 17.7 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EFA77085.1 - 0.0021 17.5 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.12 EFA77085.1 - 0.0031 17.1 0.1 0.0051 16.4 0.1 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 EFA77085.1 - 0.0041 16.9 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 EFA77085.1 - 0.017 14.8 0.1 0.089 12.5 0.1 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.18 EFA77085.1 - 0.041 13.2 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 EFA77085.1 - 0.054 13.1 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EFA77085.1 - 0.083 12.6 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein ETF PF01012.21 EFA77086.1 - 1.8e-39 135.5 0.7 2.7e-39 134.9 0.7 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EFA77086.1 - 4.6e-37 125.9 1.6 9.4e-37 124.9 1.6 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain LRR_6 PF13516.6 EFA77087.1 - 5.6e-16 57.2 46.8 0.0041 17.1 0.6 11.7 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.7 EFA77087.1 - 2.2e-06 27.9 59.2 0.0066 16.8 3.8 9.3 7 1 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA77087.1 - 0.00029 20.5 45.6 0.3 10.9 4.3 9.6 4 4 2 7 7 7 4 Leucine rich repeat LRR_1 PF00560.33 EFA77087.1 - 0.0061 16.9 32.4 46 5.1 0.2 11.5 12 1 0 12 12 12 0 Leucine Rich Repeat Gp_dh_N PF00044.24 EFA77087.1 - 0.044 14.1 0.7 1.1 9.6 0.0 3.5 5 0 0 5 5 5 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain LRR_2 PF07723.13 EFA77087.1 - 1.7 9.4 7.0 5.1 7.9 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat Kelch_6 PF13964.6 EFA77088.1 - 2.6e-12 46.5 3.0 1.4e-05 25.2 0.0 5.0 5 0 0 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA77088.1 - 0.00061 19.9 8.2 0.00061 19.9 8.2 2.0 2 0 0 2 2 2 1 B-box zinc finger Kelch_1 PF01344.25 EFA77088.1 - 0.31 10.7 0.1 0.31 10.7 0.1 3.8 4 1 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 EFA77088.1 - 7 6.7 10.5 4.9 7.2 0.1 3.5 4 0 0 4 4 4 0 Kelch motif RhoGAP PF00620.27 EFA77089.1 - 8.4e-31 106.8 0.9 1.5e-29 102.8 0.0 2.5 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EFA77089.1 - 3e-09 37.1 0.1 1e-08 35.3 0.1 2.0 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Mvb12 PF09452.10 EFA77089.1 - 0.0038 17.6 0.3 0.03 14.8 0.3 2.6 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 PP28 PF10252.9 EFA77089.1 - 0.076 13.5 1.4 0.24 11.9 1.4 1.9 1 1 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 UvrA_DNA-bind PF17755.1 EFA77089.1 - 0.1 12.9 0.1 0.32 11.4 0.1 1.8 1 0 0 1 1 1 0 UvrA DNA-binding domain Vps5 PF09325.10 EFA77089.1 - 2.1 7.8 8.7 1.7 8.1 5.2 2.1 2 0 0 2 2 2 0 Vps5 C terminal like Prominin PF05478.11 EFA77089.1 - 4 5.3 8.2 2.6 5.9 0.7 2.3 2 1 0 3 3 3 0 Prominin Ank_5 PF13857.6 EFA77091.1 - 1.6e-06 28.3 2.9 32 5.0 0.0 7.2 5 3 2 8 8 8 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA77091.1 - 2e-06 28.2 2.1 6 7.6 0.0 6.0 5 3 2 7 7 7 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA77091.1 - 2.6e-06 27.9 3.8 0.2 12.3 0.3 4.1 1 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA77091.1 - 0.00028 21.1 1.0 1e+02 4.0 0.0 6.4 7 1 1 8 8 8 0 Ankyrin repeat DUF249 PF03158.13 EFA77091.1 - 0.00034 20.4 8.0 0.056 13.2 0.2 3.5 2 1 1 4 4 4 2 Multigene family 530 protein TPR_17 PF13431.6 EFA77092.1 - 5.5e-88 283.2 5.4 2.7e-11 43.0 0.1 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77092.1 - 1.4e-20 72.7 14.2 0.039 13.6 0.1 8.2 8 0 0 8 8 8 8 TPR repeat Anth_Ig PF05587.13 EFA77092.1 - 0.0014 18.9 9.0 24 5.3 0.0 6.2 7 0 0 7 7 7 0 Anthrax receptor extracellular domain DUF1153 PF06627.11 EFA77092.1 - 0.0022 18.1 0.2 1.2e+02 2.9 0.0 6.2 8 0 0 8 8 8 0 Protein of unknown function (DUF1153) DUF2155 PF09923.9 EFA77092.1 - 0.0038 17.4 0.6 16 5.8 0.0 4.9 2 2 2 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2155) Tudor_RapA PF18337.1 EFA77092.1 - 0.0066 16.6 1.6 10 6.4 0.0 4.1 5 0 0 5 5 5 2 RapA N-terminal Tudor like domain Ntox46 PF15538.6 EFA77092.1 - 0.0074 16.3 1.1 23 4.9 0.0 4.5 1 1 4 5 5 5 0 Bacterial toxin 46 NleF_casp_inhib PF16809.5 EFA77092.1 - 0.18 11.7 6.1 29 4.5 0.1 4.9 4 1 2 6 6 6 0 NleF caspase inhibitor Ank_5 PF13857.6 EFA77094.1 - 2.1e-18 66.1 0.6 3e-07 30.6 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA77094.1 - 7.4e-18 64.9 2.3 7.1e-10 39.3 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFA77094.1 - 9.8e-13 47.9 4.1 3.7e-05 24.0 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EFA77094.1 - 1.7e-12 46.4 0.5 0.00045 20.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFA77094.1 - 7.3e-12 45.6 4.4 1.1e-06 29.0 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Mso1_Sec1_bdg PF14475.6 EFA77094.1 - 0.26 10.9 6.9 0.42 10.3 4.5 2.2 2 0 0 2 2 2 0 Sec1-binding region of Mso1 Pkinase PF00069.25 EFA77095.1 - 3.7e-72 242.9 0.0 5.7e-72 242.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77095.1 - 1.7e-46 158.6 0.0 2.6e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 EFA77095.1 - 1.3e-31 108.2 29.8 4.2e-07 30.5 0.4 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat PB1 PF00564.24 EFA77095.1 - 1.3e-13 50.6 0.1 3.5e-13 49.3 0.0 1.8 2 0 0 2 2 2 1 PB1 domain F-box PF00646.33 EFA77095.1 - 3.6e-10 39.5 0.3 8.3e-10 38.3 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA77095.1 - 3.3e-08 33.3 0.1 6.9e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EFA77095.1 - 3.3e-05 24.1 2.1 7.4 6.9 0.1 4.8 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase_fungal PF17667.1 EFA77095.1 - 4.5e-05 22.4 0.0 0.0001 21.2 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFA77095.1 - 5.3e-05 22.7 0.0 0.00015 21.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like MFS_1 PF07690.16 EFA77096.1 - 2.6e-55 187.8 58.7 6e-53 180.0 60.9 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFA77096.1 - 6.8e-19 67.7 29.6 9.7e-19 67.2 29.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFA77096.1 - 1.3e-14 54.0 17.9 1.3e-14 54.0 17.9 3.0 2 1 0 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 EFA77096.1 - 0.0014 17.6 9.3 0.0014 17.6 9.3 3.5 2 1 1 3 3 3 2 MFS_1 like family Enolase_C PF00113.22 EFA77097.1 - 4.8e-149 495.5 0.0 6e-149 495.2 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EFA77097.1 - 9.8e-59 197.2 0.1 1.5e-58 196.6 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EFA77097.1 - 4.5e-10 39.5 0.0 7.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EFA77097.1 - 0.00011 21.4 0.1 0.00026 20.3 0.1 1.6 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus TT_ORF2 PF02957.15 EFA77100.1 - 0.13 13.2 3.1 0.27 12.1 3.1 1.5 1 0 0 1 1 1 0 TT viral ORF2 USP19_linker PF16602.5 EFA77100.1 - 0.29 11.7 5.9 0.85 10.2 5.9 1.7 1 0 0 1 1 1 0 Linker region of USP19 deubiquitinase Tox-URI2 PF15653.6 EFA77100.1 - 1.5 9.1 8.5 2.6 8.3 8.5 1.4 1 0 0 1 1 1 0 URI fold toxin 2 PEX11 PF05648.14 EFA77102.1 - 2.7e-34 118.6 1.0 5.3e-17 62.0 0.1 2.0 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Cyt-b5 PF00173.28 EFA77103.1 - 3.4e-19 68.8 0.1 4.5e-18 65.2 0.0 2.6 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.21 EFA77103.1 - 1e-17 64.7 0.0 4.3e-17 62.7 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFA77103.1 - 6.8e-08 32.8 1.3 6.8e-08 32.8 1.3 3.5 2 2 0 2 2 2 1 Ferric reductase NAD binding domain Actin PF00022.19 EFA77104.1 - 7.3e-78 262.0 0.0 1.8e-47 161.8 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFA77104.1 - 0.00021 20.3 0.0 0.0011 17.8 0.0 2.0 1 1 0 1 1 1 1 MreB/Mbl protein baeRF_family10 PF18854.1 EFA77104.1 - 0.19 11.9 0.0 0.29 11.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 NAD_binding_10 PF13460.6 EFA77105.1 - 1.1e-09 38.4 0.0 1.8e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFA77105.1 - 1.5e-09 37.7 0.0 6e-09 35.7 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA77105.1 - 1.9e-09 37.1 0.0 9.1e-08 31.5 0.0 2.2 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EFA77105.1 - 5.4e-08 32.2 0.2 4.7e-07 29.1 0.1 2.0 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EFA77105.1 - 5.8e-08 32.6 0.0 1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EFA77105.1 - 4.5e-05 23.0 0.5 0.0002 20.9 0.0 2.1 2 1 1 3 3 3 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFA77105.1 - 0.00019 20.7 1.2 0.82 8.8 0.0 3.2 2 1 1 3 3 3 3 Male sterility protein adh_short PF00106.25 EFA77105.1 - 0.0083 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA77105.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Complex1_LYR PF05347.15 EFA77106.1 - 2.7e-07 30.5 0.1 4e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) RapA_C PF12137.8 EFA77106.1 - 0.019 14.0 0.2 0.02 14.0 0.2 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal DUF1394 PF07159.12 EFA77107.1 - 1.2e-106 356.4 0.9 1.5e-106 356.1 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Voltage_CLC PF00654.20 EFA77108.1 - 5.3e-43 147.6 14.5 2.2e-42 145.6 14.4 1.8 1 1 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 EFA77108.1 - 3.4e-06 27.4 1.9 0.013 16.0 0.1 3.4 3 0 0 3 3 3 2 CBS domain XhlA PF10779.9 EFA77108.1 - 0.0021 18.3 0.2 0.0057 16.8 0.2 1.8 1 0 0 1 1 1 1 Haemolysin XhlA Phage_holin_5_2 PF16079.5 EFA77108.1 - 0.0049 17.2 3.3 1.1 9.7 0.5 2.9 2 0 0 2 2 2 2 Phage holin family Hol44, in holin superfamily V GRIM-19 PF06212.12 EFA77108.1 - 0.007 16.3 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 GRIM-19 protein DUF3884 PF13024.6 EFA77108.1 - 0.14 11.7 0.1 0.34 10.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) DUF2207 PF09972.9 EFA77108.1 - 0.94 8.2 8.8 0.14 10.9 0.1 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Glyoxalase PF00903.25 EFA77109.1 - 1.1e-20 74.1 1.8 3.4e-16 59.6 0.1 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFA77109.1 - 2.7e-09 37.3 0.1 0.0022 18.2 0.0 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFA77109.1 - 0.00013 22.1 1.0 0.65 10.1 0.0 3.4 3 2 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EFA77109.1 - 0.00063 19.9 0.2 0.0016 18.6 0.1 1.7 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal ELO PF01151.18 EFA77110.1 - 1.6e-54 185.1 24.3 2e-54 184.8 24.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family N6_Mtase PF02384.16 EFA77110.1 - 0.019 14.2 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Ank_2 PF12796.7 EFA77113.1 - 4.5e-34 116.9 7.4 3.8e-08 33.8 0.1 8.5 3 3 6 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77113.1 - 3.5e-25 88.0 5.8 0.0001 22.8 0.0 9.6 9 2 1 10 10 10 6 Ankyrin repeats (many copies) HPP PF04982.13 EFA77113.1 - 3.8e-25 88.4 0.2 7.5e-25 87.5 0.2 1.5 1 0 0 1 1 1 1 HPP family Ank_3 PF13606.6 EFA77113.1 - 9.4e-19 65.6 3.8 0.79 10.5 0.0 12.1 13 0 0 13 13 13 4 Ankyrin repeat Ank_5 PF13857.6 EFA77113.1 - 1.3e-18 66.8 4.5 0.16 12.3 0.0 9.1 5 2 6 11 11 11 5 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA77113.1 - 0.00088 19.1 11.4 2.7 7.9 0.0 6.6 4 1 3 7 7 7 2 Domain of unknown function (DUF5049) Ank_2 PF12796.7 EFA77114.1 - 8.4e-32 109.6 13.9 1.8e-06 28.4 0.0 8.9 3 2 9 12 12 12 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77114.1 - 8e-30 102.8 8.3 0.0011 19.5 0.0 11.2 8 3 2 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77114.1 - 7.7e-29 99.4 3.0 0.0026 18.0 0.0 12.1 4 4 7 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77114.1 - 2.7e-18 64.1 7.6 1.3 9.8 0.0 15.2 14 3 3 17 17 17 1 Ankyrin repeat DUF5049 PF16468.5 EFA77114.1 - 4.1e-07 29.8 11.5 4 7.4 0.0 8.8 6 1 3 9 9 9 2 Domain of unknown function (DUF5049) Ank_2 PF12796.7 EFA77115.1 - 3.9e-37 126.7 16.9 2.4e-09 37.7 0.1 9.4 3 3 6 11 11 11 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77115.1 - 3.2e-30 104.1 16.3 5.8e-05 23.6 0.0 11.8 7 4 4 11 11 11 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77115.1 - 2.9e-29 100.7 19.2 0.00033 20.9 0.0 15.8 8 3 10 18 18 18 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77115.1 - 3.9e-16 57.5 14.1 0.77 10.5 0.0 15.2 16 1 2 18 18 18 1 Ankyrin repeat DUF5049 PF16468.5 EFA77115.1 - 3e-09 36.6 16.7 1.1 9.2 0.0 11.1 7 2 5 12 12 12 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA77115.1 - 0.00078 19.8 0.8 59 4.4 0.0 7.4 7 2 0 7 7 7 0 Ankyrin repeat Helicase_PWI PF18149.1 EFA77115.1 - 0.039 14.1 0.7 5.1 7.3 0.0 4.4 4 2 0 4 4 4 0 N-terminal helicase PWI domain CBFD_NFYB_HMF PF00808.23 EFA77116.1 - 2.8e-19 69.1 0.4 4.3e-19 68.6 0.4 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFA77116.1 - 6.9e-14 52.3 1.3 1.4e-13 51.3 1.3 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EFA77116.1 - 0.15 12.4 0.1 0.32 11.3 0.1 1.5 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Methyltrans_SAM PF10672.9 EFA77117.1 - 4.7e-24 85.0 0.2 6.9e-24 84.5 0.2 1.2 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 EFA77117.1 - 0.0068 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 EFA77117.1 - 0.011 15.4 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Pertus-S5-tox PF09276.10 EFA77117.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Pertussis toxin S5 subunit MMS1_N PF10433.9 EFA77118.1 - 1.5e-31 109.6 12.2 1.5e-31 109.6 12.2 3.1 2 2 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term NINJA_B PF16136.5 EFA77118.1 - 0.19 12.1 1.6 0.7 10.3 1.6 2.0 1 0 0 1 1 1 0 Putative nuclear localisation signal SUIM_assoc PF16619.5 EFA77118.1 - 1 9.5 12.2 0.092 12.8 6.9 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2028 PF09667.10 EFA77119.1 - 0.056 13.4 0.1 0.073 13.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2028) Ada_Zn_binding PF02805.16 EFA77120.1 - 2.1e-08 34.1 0.0 3.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada Motile_Sperm PF00635.26 EFA77121.1 - 4.3 7.2 24.6 12 5.7 0.2 7.6 8 0 0 8 8 8 0 MSP (Major sperm protein) domain ASH PF15780.5 EFA77122.1 - 0.00086 19.5 0.0 0.2 11.9 0.0 3.7 2 1 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 EFA77122.1 - 0.022 14.8 0.3 1.3 9.1 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1573) eIF-5a PF01287.20 EFA77123.1 - 1.2e-19 70.2 0.4 2.8e-19 69.0 0.4 1.7 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold FNIP PF05725.12 EFA77123.1 - 0.0074 16.4 0.0 0.0074 16.4 0.0 2.5 3 0 0 3 3 3 1 FNIP Repeat DUF1128 PF06569.11 EFA77123.1 - 0.012 15.6 0.1 0.035 14.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Rtt102p PF09510.10 EFA77123.1 - 0.1 12.8 0.7 0.2 11.9 0.7 1.4 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein DUF4848 PF16140.5 EFA77123.1 - 0.12 12.0 4.5 2.9 7.4 1.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4848) C2 PF00168.30 EFA77124.1 - 2.3e-22 79.2 0.0 7.1e-22 77.6 0.0 1.9 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 EFA77124.1 - 6.3e-05 23.6 0.0 0.05 14.2 0.0 3.6 3 0 0 3 3 3 1 Putative heavy-metal-binding DUF4156 PF13698.6 EFA77124.1 - 0.00012 22.3 0.1 0.6 10.5 0.0 4.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4156) Ank_2 PF12796.7 EFA77125.1 - 8.2e-26 90.4 12.6 1.4e-07 32.0 1.4 6.9 1 1 6 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77125.1 - 3e-23 81.9 11.3 3.3e-06 27.5 0.1 10.0 5 4 4 9 9 9 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77125.1 - 2.2e-19 69.3 4.9 0.0057 16.9 0.2 10.3 7 3 7 14 14 14 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77125.1 - 2.1e-13 49.1 2.3 13 6.7 0.0 11.2 14 0 0 14 14 14 1 Ankyrin repeat DUF3447 PF11929.8 EFA77125.1 - 0.0039 17.1 15.8 1.9 8.5 0.1 5.8 3 2 2 5 5 5 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA77125.1 - 0.12 12.9 2.0 2.1e+02 2.6 0.0 5.6 5 2 0 6 6 6 0 Ankyrin repeat DUF1707 PF08044.11 EFA77125.1 - 0.17 12.0 0.0 3.8 7.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) zf-B_box PF00643.24 EFA77126.1 - 3.5e-06 27.1 5.7 8.6e-06 25.8 5.7 1.7 1 0 0 1 1 1 1 B-box zinc finger Cep57_CLD PF14073.6 EFA77126.1 - 0.34 10.9 6.7 0.26 11.3 5.2 1.6 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 RVT_1 PF00078.27 EFA77127.1 - 1.1e-13 51.2 0.0 3.1e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EFA77127.1 - 8.7e-13 48.5 0.0 2.4e-12 47.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EFA77127.1 - 1.6e-06 28.2 0.1 3.6e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain MLVIN_C PF18697.1 EFA77127.1 - 0.097 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Pox_Ag35 PF03286.14 EFA77127.1 - 0.37 10.6 6.4 0.68 9.7 6.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Kelch_6 PF13964.6 EFA77128.1 - 6.4e-15 54.8 7.1 2.4e-05 24.5 0.0 5.2 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFA77128.1 - 3.9e-06 27.0 0.1 0.0035 17.6 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA77128.1 - 2.3e-05 24.3 1.5 1.9 8.6 0.1 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain DUF5074 PF16819.5 EFA77128.1 - 0.079 13.0 19.7 1.7 8.7 3.0 4.3 2 2 2 4 4 4 0 Domain of unknown function (DUF5074) Gp_dh_N PF00044.24 EFA77128.1 - 0.22 11.9 2.6 3.8 7.9 0.2 2.6 1 1 1 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Ank_2 PF12796.7 EFA77129.1 - 3.2e-26 91.7 8.6 2.8e-06 27.8 0.1 6.3 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77129.1 - 1.4e-23 82.9 12.4 3.1e-05 24.4 0.0 9.2 6 3 3 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77129.1 - 7.1e-16 58.1 8.7 0.3 11.5 0.1 11.1 5 3 7 12 12 12 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77129.1 - 1e-12 47.0 7.2 24 5.9 0.0 11.7 14 0 0 14 14 14 1 Ankyrin repeat DUF5049 PF16468.5 EFA77129.1 - 0.00047 20.0 1.8 46 4.0 0.0 6.7 6 1 2 8 8 8 0 Domain of unknown function (DUF5049) PatG_C PF18065.1 EFA77129.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 PatG C-terminal Pep3_Vps18 PF05131.14 EFA77130.1 - 6.2e-43 146.2 0.0 3.3e-42 143.8 0.0 2.3 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EFA77130.1 - 1.9e-14 53.7 2.9 1.9e-14 53.7 2.9 3.4 3 1 0 3 3 3 1 Region in Clathrin and VPS zf-RING_5 PF14634.6 EFA77130.1 - 0.00031 20.7 2.8 0.00076 19.4 2.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFA77130.1 - 0.00065 19.3 0.9 0.00065 19.3 0.9 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EFA77130.1 - 0.00084 19.6 3.0 0.0026 18.1 3.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA77130.1 - 0.0017 18.2 3.0 0.0049 16.7 3.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA77130.1 - 0.0045 16.7 4.2 0.013 15.2 4.2 1.9 1 0 0 1 1 1 1 RING-like zinc finger DUF2175 PF09943.9 EFA77130.1 - 0.0048 17.2 0.3 0.018 15.3 0.3 2.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2175) zf-C3H2C3 PF17122.5 EFA77130.1 - 0.011 15.8 2.6 0.024 14.6 2.6 1.6 1 0 0 1 1 1 0 Zinc-finger zf-RING_UBOX PF13445.6 EFA77130.1 - 0.011 15.7 1.8 0.033 14.2 1.8 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Vps39_2 PF10367.9 EFA77130.1 - 0.019 15.4 0.3 0.084 13.3 0.1 2.2 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 Zf_RING PF16744.5 EFA77130.1 - 0.041 14.0 1.3 0.11 12.6 1.3 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Lipocalin_7 PF14651.6 EFA77130.1 - 0.076 13.0 0.7 0.16 11.9 0.1 1.8 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family NOG1_N PF17835.1 EFA77130.1 - 0.08 12.9 0.1 0.25 11.3 0.1 1.8 1 0 0 1 1 1 0 NOG1 N-terminal helical domain zf-ANAPC11 PF12861.7 EFA77130.1 - 0.15 12.1 0.2 0.38 10.9 0.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFA77130.1 - 0.25 11.6 1.0 0.85 10.0 1.0 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFA77130.1 - 0.3 11.0 2.5 0.9 9.5 2.5 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_1 PF00515.28 EFA77130.1 - 0.48 10.3 7.4 32 4.5 0.3 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA77130.1 - 0.53 10.5 4.7 4.8 7.5 0.2 3.8 3 0 0 3 3 2 0 Tetratricopeptide repeat ArfGap PF01412.18 EFA77131.1 - 3.7e-24 85.1 4.9 3.7e-24 85.1 4.9 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SH3_9 PF14604.6 EFA77131.1 - 3.1e-13 49.3 0.1 9.3e-13 47.8 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA77131.1 - 3e-10 39.5 0.0 5.8e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA77131.1 - 2.2e-05 24.1 0.0 4.4e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RBD PF02196.15 EFA77131.1 - 0.007 16.4 0.0 0.035 14.2 0.0 2.2 2 0 0 2 2 2 1 Raf-like Ras-binding domain GDPD PF03009.17 EFA77131.1 - 0.062 13.0 0.1 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family TPR_17 PF13431.6 EFA77133.1 - 3.2e-197 625.4 23.5 1.4e-11 43.9 0.0 16.4 17 0 0 17 17 16 16 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77133.1 - 2.6e-27 94.2 45.6 0.41 10.4 0.2 15.9 16 0 0 16 16 16 12 TPR repeat NleF_casp_inhib PF16809.5 EFA77133.1 - 4.7e-10 39.6 14.1 30 4.5 0.0 12.5 3 3 11 14 14 14 0 NleF caspase inhibitor DUF1153 PF06627.11 EFA77133.1 - 4.7e-06 26.6 0.0 90 3.3 0.0 10.0 16 0 0 16 16 16 0 Protein of unknown function (DUF1153) DUF2155 PF09923.9 EFA77133.1 - 4.5e-05 23.6 7.4 43 4.5 0.0 8.5 5 3 4 10 10 10 0 Uncharacterized protein conserved in bacteria (DUF2155) DUF3693 PF12472.8 EFA77133.1 - 7.2e-05 22.4 2.7 1.4e+02 2.2 0.0 8.4 10 0 0 10 10 10 0 Phage related protein Ntox46 PF15538.6 EFA77133.1 - 0.00039 20.4 11.5 72 3.3 0.0 10.0 1 1 14 15 15 15 0 Bacterial toxin 46 Glyco_hydro_61 PF03443.14 EFA77133.1 - 0.00068 19.6 24.3 11 5.8 0.0 10.4 5 3 6 11 11 11 1 Glycosyl hydrolase family 61 DUF4017 PF13209.6 EFA77133.1 - 0.021 14.8 0.0 8.7 6.4 0.0 5.1 8 0 0 8 8 7 0 Protein of unknown function (DUF4017) DUF2959 PF11172.8 EFA77133.1 - 0.052 13.7 3.9 18 5.4 0.0 5.1 3 3 4 7 7 7 0 Protein of unknown function (DUF2959) bPH_1 PF08000.11 EFA77133.1 - 0.29 11.2 7.5 16 5.6 0.0 6.3 8 1 1 9 9 9 0 Bacterial PH domain Anth_Ig PF05587.13 EFA77133.1 - 1.4 9.3 23.4 67 3.9 0.0 10.1 14 0 0 14 14 14 0 Anthrax receptor extracellular domain TPR_17 PF13431.6 EFA77134.1 - 1.2e-57 188.2 7.0 1.8e-08 34.2 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77134.1 - 1.8e-07 30.7 11.5 0.02 14.6 0.2 6.0 6 0 0 6 6 6 2 TPR repeat DUF1153 PF06627.11 EFA77134.1 - 0.00019 21.5 0.0 40 4.4 0.0 5.1 5 0 0 5 5 5 0 Protein of unknown function (DUF1153) Anth_Ig PF05587.13 EFA77134.1 - 0.00036 20.8 0.5 8.1 6.8 0.0 5.0 5 0 0 5 5 5 1 Anthrax receptor extracellular domain P22_CoatProtein PF11651.8 EFA77134.1 - 0.0041 15.8 0.0 0.2 10.2 0.0 2.7 3 1 1 4 4 4 1 P22 coat protein - gene protein 5 SeqA_N PF17206.3 EFA77134.1 - 0.013 14.8 0.6 0.23 10.8 0.1 2.9 2 0 0 2 2 2 0 SeqA protein N-terminal domain NleF_casp_inhib PF16809.5 EFA77134.1 - 0.018 15.0 0.4 34 4.3 0.1 4.0 4 1 1 5 5 5 0 NleF caspase inhibitor MapZ_C2 PF18708.1 EFA77134.1 - 0.038 14.3 2.3 0.69 10.2 0.1 3.4 2 1 2 4 4 4 0 MapZ extracellular C-terminal domain 2 DUF1344 PF07076.11 EFA77134.1 - 0.05 13.5 0.5 8.4 6.4 0.0 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF1344) Ank_2 PF12796.7 EFA77136.1 - 2.6e-38 130.5 10.5 1.2e-06 29.0 0.0 11.6 5 2 6 12 12 12 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77136.1 - 8.6e-28 96.4 11.5 0.0064 17.0 0.0 14.2 15 3 2 17 17 17 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77136.1 - 5e-25 87.2 14.7 0.12 12.8 0.0 15.8 13 5 5 19 19 19 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77136.1 - 5.8e-19 66.2 14.0 3.7 8.4 0.0 19.0 22 0 0 22 22 22 1 Ankyrin repeat Ank PF00023.30 EFA77136.1 - 0.0014 19.0 0.3 3.3e+02 2.0 0.0 7.9 11 2 0 11 11 11 0 Ankyrin repeat P2_Phage_GpR PF06891.11 EFA77136.1 - 1.5 8.9 4.2 43 4.2 0.0 4.3 5 0 0 5 5 5 0 P2 phage tail completion protein R (GpR) Bud13 PF09736.9 EFA77137.1 - 4.8e-43 147.0 18.5 4.8e-43 147.0 18.5 3.4 3 1 1 4 4 4 1 Pre-mRNA-splicing factor of RES complex PI3_PI4_kinase PF00454.27 EFA77138.1 - 1.4e-54 185.6 0.0 1e-51 176.1 0.0 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFA77138.1 - 8.6e-50 168.7 2.9 1.7e-49 167.7 2.9 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EFA77138.1 - 9.1e-31 106.6 0.0 2e-30 105.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PRD PF00874.20 EFA77138.1 - 0.0016 18.7 1.6 0.68 10.3 2.0 2.9 2 1 1 3 3 3 1 PRD domain HEAT_2 PF13646.6 EFA77138.1 - 0.07 13.5 0.5 0.38 11.2 0.1 2.1 2 0 0 2 2 2 0 HEAT repeats FPRL1_inhibitor PF16104.5 EFA77138.1 - 0.086 13.0 0.2 26 5.0 0.1 3.1 2 0 0 2 2 2 0 Formyl peptide receptor-like 1 inhibitory protein DUF4868 PF16162.5 EFA77138.1 - 0.18 11.7 4.8 0.21 11.5 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4868) RcpB PF16971.5 EFA77140.1 - 0.05 13.5 0.2 0.057 13.3 0.2 1.1 1 0 0 1 1 1 0 Rough colony protein B, tight adherence - tad - subunit NAD_binding_5 PF07994.12 EFA77141.1 - 6.5e-144 479.2 0.0 7.6e-144 479.0 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EFA77141.1 - 4.6e-48 162.0 0.4 1e-47 160.9 0.4 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Peptidase_M1 PF01433.20 EFA77142.1 - 1.2e-73 247.3 3.6 2e-73 246.6 3.6 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFA77142.1 - 2.3e-42 145.7 0.2 4.1e-42 144.8 0.2 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFA77142.1 - 1.9e-40 139.0 2.8 1.9e-40 139.0 2.8 1.9 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain MADF_DNA_bdg PF10545.9 EFA77142.1 - 0.03 14.6 2.6 19 5.6 0.2 4.6 5 0 0 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Usher PF00577.20 EFA77143.1 - 0.0017 17.3 10.0 0.002 17.0 10.0 1.2 1 0 0 1 1 1 1 Outer membrane usher protein Macoilin PF09726.9 EFA77143.1 - 0.026 13.1 13.6 0.037 12.6 13.6 1.2 1 0 0 1 1 1 0 Macoilin family Myosin_head PF00063.21 EFA77144.1 - 5.1e-268 890.8 4.6 6.2e-268 890.6 4.6 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFA77144.1 - 3.3e-38 131.3 0.0 5.9e-38 130.4 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EFA77144.1 - 1.4e-06 27.6 14.8 0.0012 18.4 2.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EFA77144.1 - 0.0017 18.6 0.2 0.036 14.3 0.1 3.0 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFA77144.1 - 0.0047 16.2 0.0 0.011 15.0 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EFA77144.1 - 0.0051 17.2 0.0 0.019 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EFA77144.1 - 0.047 14.2 0.4 0.17 12.4 0.1 2.2 2 1 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 EFA77144.1 - 0.065 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EFA77144.1 - 0.076 13.6 0.2 0.26 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF3638 PF12340.8 EFA77145.1 - 3.3e-59 200.0 0.2 6.5e-59 199.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EFA77145.1 - 1.5e-10 40.3 0.0 3.1e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) SUIM_assoc PF16619.5 EFA77147.1 - 0.022 14.8 13.6 0.07 13.2 13.6 1.8 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Androgen_recep PF02166.16 EFA77147.1 - 0.45 9.3 10.7 0.41 9.4 10.7 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 EFA77147.1 - 1.7 8.2 16.2 2.1 7.9 16.2 1.1 1 0 0 1 1 1 0 Spt20 family zf-C3HC PF07967.13 EFA77148.1 - 8.6e-16 58.2 0.7 8.6e-16 58.2 0.7 3.1 3 0 0 3 3 3 1 C3HC zinc finger-like Rsm1 PF08600.10 EFA77148.1 - 0.00012 22.1 0.1 0.00012 22.1 0.1 3.3 2 1 0 3 3 3 1 Rsm1-like DUF1682 PF07946.14 EFA77148.1 - 0.013 14.8 1.1 0.013 14.8 1.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) BIR PF00653.21 EFA77148.1 - 0.034 14.8 2.9 7.2 7.3 0.3 2.6 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain SDH_beta PF03315.15 EFA77148.1 - 0.22 11.9 0.8 0.85 10.0 0.2 2.2 3 0 0 3 3 3 0 Serine dehydratase beta chain Stc1 PF12898.7 EFA77148.1 - 2 9.0 0.0 2 9.0 0.0 3.4 2 1 0 3 3 3 0 Stc1 domain Adeno_E1B_55K_N PF04623.12 EFA77149.1 - 0.052 14.3 0.7 0.091 13.5 0.7 1.4 1 0 0 1 1 1 0 Adenovirus E1B protein N-terminus Endotoxin_N PF03945.14 EFA77151.1 - 1.5e-08 34.7 0.4 3.8e-08 33.3 0.4 1.7 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain CDtoxinA PF03498.14 EFA77151.1 - 1.8e-05 24.4 1.3 0.054 13.1 0.1 2.9 3 0 0 3 3 3 2 Cytolethal distending toxin A/C domain Ricin_B_lectin PF00652.22 EFA77151.1 - 1.9e-05 24.9 2.1 0.0042 17.3 0.2 3.2 2 1 0 3 3 3 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EFA77151.1 - 0.02 15.6 5.9 0.66 10.7 0.0 3.9 3 1 1 4 4 4 0 Ricin-type beta-trefoil lectin domain-like ATG_C PF09333.11 EFA77152.1 - 9.5e-18 64.3 0.3 1.1e-07 32.1 0.0 2.9 2 0 0 2 2 2 2 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EFA77152.1 - 4e-07 30.0 6.5 0.0019 18.0 0.5 2.5 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal zf-B_box PF00643.24 EFA77152.1 - 0.003 17.7 5.3 0.0053 16.9 5.3 1.3 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 EFA77152.1 - 0.047 13.9 6.2 0.089 13.0 6.2 1.4 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain SET PF00856.28 EFA77152.1 - 6.2 7.2 8.8 6.7 7.1 6.3 2.2 2 0 0 2 2 2 0 SET domain Lactamase_B_2 PF12706.7 EFA77153.1 - 6.5e-20 71.5 0.0 3.1e-14 53.0 0.2 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 EFA77153.1 - 2.7e-10 39.8 0.1 1.6e-09 37.3 0.0 2.2 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B PF00753.27 EFA77153.1 - 0.009 16.0 0.0 0.037 14.0 0.2 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily BAR PF03114.18 EFA77154.1 - 7.3e-17 61.8 11.9 3.9e-16 59.4 11.9 1.9 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.6 EFA77154.1 - 6.3e-15 54.8 0.1 9.8e-15 54.2 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA77154.1 - 4.5e-13 48.6 0.0 8.6e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA77154.1 - 1.9e-11 43.5 0.0 3.6e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Sec34 PF04136.15 EFA77154.1 - 0.0024 17.8 1.4 0.013 15.4 0.7 2.2 1 1 1 2 2 2 1 Sec34-like family DUF1664 PF07889.12 EFA77154.1 - 0.027 14.5 5.7 0.028 14.5 2.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DASH_Dad4 PF08650.10 EFA77154.1 - 0.03 14.3 0.2 0.079 12.9 0.2 1.7 1 0 0 1 1 1 0 DASH complex subunit Dad4 Laminin_II PF06009.12 EFA77154.1 - 0.1 12.6 1.8 0.22 11.5 0.3 2.1 1 1 0 2 2 2 0 Laminin Domain II SlyX PF04102.12 EFA77154.1 - 0.17 12.6 1.0 33 5.2 0.1 3.2 2 1 0 2 2 2 0 SlyX Fib_alpha PF08702.10 EFA77154.1 - 0.34 11.1 6.4 0.46 10.7 1.7 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family MADF_DNA_bdg PF10545.9 EFA77154.1 - 1.9 8.8 5.9 19 5.6 0.0 3.0 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like I_LWEQ PF01608.17 EFA77155.1 - 6.8e-51 172.5 179.3 1.5e-40 139.0 15.2 17.4 6 5 12 19 19 19 7 I/LWEQ domain FERM_f0 PF16511.5 EFA77155.1 - 7.6e-31 106.3 0.0 2.6e-25 88.5 0.0 2.8 2 0 0 2 2 2 2 N-terminal or F0 domain of Talin-head FERM FERM_M PF00373.18 EFA77155.1 - 2.3e-24 86.1 1.0 2.3e-24 86.1 1.0 2.9 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.10 EFA77155.1 - 1.3e-11 44.3 0.2 5.8e-10 39.0 0.0 3.1 2 0 0 2 2 2 1 FERM N-terminal domain VBS PF08913.10 EFA77155.1 - 1.6e-06 28.6 1.0 1.6e-06 28.6 1.0 12.9 11 2 1 14 14 14 4 Vinculin Binding Site PID PF00640.23 EFA77155.1 - 0.00022 21.2 3.4 0.0011 19.0 0.0 4.0 4 0 0 4 4 4 1 Phosphotyrosine interaction domain (PTB/PID) IRS PF02174.17 EFA77155.1 - 0.00041 20.2 0.0 0.0014 18.5 0.0 1.9 1 0 0 1 1 1 1 PTB domain (IRS-1 type) YukD PF08817.10 EFA77155.1 - 0.00051 20.7 0.0 0.0036 18.0 0.0 2.5 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD Rad60-SLD PF11976.8 EFA77155.1 - 0.0043 16.9 0.2 0.024 14.4 0.2 2.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFA77155.1 - 0.47 10.2 4.1 3.4 7.5 0.9 3.7 3 1 0 3 3 3 0 Ubiquitin family FNIP PF05725.12 EFA77156.1 - 1.9e-15 56.8 31.6 3.6e-07 30.3 0.8 6.0 4 1 2 6 6 6 4 FNIP Repeat F-box_5 PF18511.1 EFA77156.1 - 0.0035 16.9 0.1 0.0088 15.6 0.1 1.7 1 0 0 1 1 1 1 F-box UBX PF00789.20 EFA77157.1 - 7.7e-14 51.7 0.1 2.1e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 UBX domain Retinin_C PF04527.12 EFA77157.1 - 0.043 14.1 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 Drosophila Retinin like protein FNIP_M PF14637.6 EFA77157.1 - 0.066 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain SWI-SNF_Ssr4 PF08549.10 EFA77157.1 - 0.076 11.6 6.7 0.099 11.3 6.7 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Cytochrom_C552 PF02335.15 EFA77157.1 - 0.12 11.3 2.3 0.12 11.2 1.5 1.4 1 1 0 1 1 1 0 Cytochrome c552 KIP1 PF07765.12 EFA77157.1 - 6.1 7.0 10.0 0.42 10.8 2.7 2.6 3 0 0 3 3 3 0 KIP1-like protein Mucin PF01456.17 EFA77158.1 - 0.034 14.1 23.2 0.071 13.1 23.2 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Endotoxin_N PF03945.14 EFA77159.1 - 0.00028 20.7 0.4 0.005 16.6 0.1 2.3 1 1 1 2 2 2 1 delta endotoxin, N-terminal domain ImcF-related_N PF14331.6 EFA77159.1 - 0.018 14.4 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 ImcF-related N-terminal domain Endotoxin_N PF03945.14 EFA77160.1 - 9.4e-05 22.2 0.1 0.011 15.4 0.0 2.3 1 1 0 2 2 2 2 delta endotoxin, N-terminal domain ImcF-related_N PF14331.6 EFA77160.1 - 0.0013 18.1 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 ImcF-related N-terminal domain SYCP2_ARLD PF18581.1 EFA77160.1 - 0.095 12.7 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Synaptonemal complex 2 armadillo-repeat-like domain Guanylate_cyc PF00211.20 EFA77162.1 - 6.3e-88 293.2 0.4 5e-46 156.6 0.1 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EFA77162.1 - 0.00021 20.8 1.2 0.0089 15.5 0.1 2.3 2 0 0 2 2 2 2 Heme NO binding associated DUF3278 PF11683.8 EFA77162.1 - 0.0035 17.4 2.2 0.0035 17.4 2.2 3.7 3 2 1 4 4 4 1 Protein of unknown function (DUF3278) FA_desaturase PF00487.24 EFA77163.1 - 7.6e-37 127.5 13.2 7.6e-37 127.5 13.2 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFA77163.1 - 1.1e-23 83.2 0.2 1.7e-22 79.4 0.0 2.6 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Endotoxin_N PF03945.14 EFA77164.1 - 5.6e-12 45.8 2.0 5.8e-12 45.8 0.6 1.8 2 0 0 2 2 2 1 delta endotoxin, N-terminal domain Dicty_CAR PF05462.11 EFA77165.1 - 5.5e-46 157.1 6.3 7.6e-46 156.6 6.3 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor ASH PF15780.5 EFA77166.1 - 2.5e-19 69.3 8.3 3.6e-06 27.1 0.0 5.9 7 0 0 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin SUKH_6 PF14568.6 EFA77166.1 - 0.36 11.2 2.5 0.62 10.5 0.1 2.8 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall Palm_thioest PF02089.15 EFA77167.1 - 0.0037 17.2 0.1 0.017 15.0 0.1 1.9 1 1 1 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 EFA77167.1 - 0.0046 17.6 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EFA77167.1 - 0.01 15.5 0.1 0.024 14.3 0.1 1.6 1 0 0 1 1 1 0 Putative esterase NAR2 PF16974.5 EFA77167.1 - 0.12 11.7 0.4 0.26 10.7 0.4 1.5 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory IMS PF00817.20 EFA77168.1 - 5.2e-34 117.4 0.0 8.7e-34 116.7 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.8 EFA77168.1 - 0.00015 21.9 0.1 0.00037 20.6 0.1 1.7 1 0 0 1 1 1 1 IMS family HHH motif GST_C_3 PF14497.6 EFA77169.1 - 3e-19 69.1 0.1 5.3e-19 68.3 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA77169.1 - 3e-11 43.5 0.0 7.4e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA77169.1 - 1.3e-07 31.8 0.0 1.8e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA77169.1 - 1.8e-05 24.7 0.0 6.1e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA77169.1 - 5.2e-05 22.9 0.0 9.7e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA77169.1 - 0.00053 20.3 0.0 0.0013 19.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain SAGA-Tad1 PF12767.7 EFA77170.1 - 2.3e-44 151.9 4.1 2.3e-44 151.9 4.1 8.1 4 3 1 5 5 5 1 Transcriptional regulator of RNA polII, SAGA, subunit RRM_1 PF00076.22 EFA77170.1 - 3.5e-25 87.6 7.2 4e-10 39.4 0.1 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FNIP PF05725.12 EFA77170.1 - 6.1e-18 64.7 15.8 1.4e-06 28.3 1.0 5.4 4 0 0 4 4 4 4 FNIP Repeat F-box_5 PF18511.1 EFA77170.1 - 5.3e-05 22.7 0.4 0.00011 21.7 0.4 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77170.1 - 0.14 12.0 0.2 0.35 10.8 0.2 1.7 1 0 0 1 1 1 0 F-box-like FNIP PF05725.12 EFA77172.1 - 1.1e-20 73.5 4.3 2.5e-10 40.4 0.0 8.6 4 2 5 10 10 10 7 FNIP Repeat AIG1 PF04548.16 EFA77173.1 - 2e-11 43.7 1.9 2.6e-11 43.3 1.9 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EFA77173.1 - 1.3e-10 41.3 0.2 2.3e-10 40.5 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA77173.1 - 6.4e-07 29.4 0.5 2.9e-06 27.3 0.1 2.1 1 1 1 2 2 2 1 RsgA GTPase GBP PF02263.19 EFA77173.1 - 1.7e-05 24.2 0.0 3.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AAA_22 PF13401.6 EFA77173.1 - 0.00022 21.5 0.0 0.0004 20.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFA77173.1 - 0.00062 20.2 0.5 0.0068 16.8 0.5 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFA77173.1 - 0.0015 19.1 0.2 0.0081 16.7 0.2 2.2 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFA77173.1 - 0.0053 17.1 0.0 0.012 16.0 0.0 1.8 1 1 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 EFA77173.1 - 0.0053 17.3 0.1 0.0099 16.4 0.1 1.4 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EFA77173.1 - 0.0081 16.6 0.0 0.016 15.6 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain Roc PF08477.13 EFA77173.1 - 0.0084 16.3 0.1 0.022 15.0 0.1 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 EFA77173.1 - 0.017 14.7 1.2 0.11 12.1 1.2 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Guanylate_kin PF00625.21 EFA77173.1 - 0.022 14.4 0.0 0.056 13.1 0.0 1.7 1 0 0 1 1 1 0 Guanylate kinase Septin PF00735.18 EFA77173.1 - 0.023 14.0 0.8 0.091 12.0 0.1 1.9 1 1 1 2 2 2 0 Septin Zeta_toxin PF06414.12 EFA77173.1 - 0.031 13.5 0.1 9.4 5.5 0.0 3.0 3 0 0 3 3 3 0 Zeta toxin AAA_28 PF13521.6 EFA77173.1 - 0.035 14.3 0.3 0.11 12.8 0.1 1.8 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFA77173.1 - 0.04 13.7 0.0 0.099 12.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Caudo_bapla16 PF16792.5 EFA77173.1 - 0.057 12.4 0.1 0.075 12.0 0.1 1.2 1 0 0 1 1 1 0 Phage tail base-plate attachment protein of Caudovirales ORF16 AAA_5 PF07728.14 EFA77173.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FNIP PF05725.12 EFA77174.1 - 9.5e-19 67.3 32.9 4.1e-08 33.2 2.9 7.0 4 2 4 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA77174.1 - 6.5e-06 25.6 0.2 1.2e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77174.1 - 0.014 15.3 0.2 0.056 13.4 0.2 2.1 1 0 0 1 1 1 0 F-box-like FNIP PF05725.12 EFA77175.1 - 2.8e-76 251.5 59.9 3.3e-13 49.6 0.0 17.3 13 6 6 19 19 19 16 FNIP Repeat F-box_5 PF18511.1 EFA77175.1 - 1.7e-07 30.7 1.0 3.7e-07 29.6 1.0 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77175.1 - 0.15 12.0 0.1 0.71 9.8 0.1 2.1 2 0 0 2 2 2 0 F-box-like Linker_histone PF00538.19 EFA77175.1 - 2.5 8.5 4.2 1.2 9.5 0.7 2.3 2 0 0 2 2 2 0 linker histone H1 and H5 family Myotub-related PF06602.14 EFA77176.1 - 5.9e-123 410.3 5.0 5.9e-123 410.3 5.0 1.7 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain CAF-1_p150 PF11600.8 EFA77176.1 - 0.0013 18.5 16.3 0.0013 18.5 16.3 2.6 3 0 0 3 3 3 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Dicty_REP PF05086.12 EFA77176.1 - 0.0022 16.1 3.8 0.0022 16.1 3.8 3.7 2 1 2 4 4 4 1 Dictyostelium (Slime Mold) REP protein Y_phosphatase3 PF13350.6 EFA77176.1 - 0.027 14.5 0.3 0.072 13.1 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family DSPc PF00782.20 EFA77176.1 - 0.038 13.8 1.8 0.074 12.9 0.0 2.3 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Mucin PF01456.17 EFA77176.1 - 0.2 11.6 33.9 0.019 15.0 12.1 3.8 3 0 0 3 3 3 0 Mucin-like glycoprotein SSP160 PF06933.11 EFA77176.1 - 2 6.5 24.1 2.1 6.5 2.7 2.6 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 EFA77176.1 - 2.8 7.9 19.9 0.23 11.4 6.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Zip PF02535.22 EFA77177.1 - 0.079 12.2 9.2 0.1 11.8 9.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rbc25 PF08292.12 EFA77177.1 - 0.23 11.7 4.2 0.52 10.6 4.2 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DARPP-32 PF05395.12 EFA77177.1 - 1.1 9.5 15.0 1.7 8.9 15.0 1.3 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 Presenilin PF01080.17 EFA77177.1 - 7.8 5.1 13.5 12 4.6 13.5 1.2 1 0 0 1 1 1 0 Presenilin RMI2 PF16100.5 EFA77178.1 - 2.6e-10 40.2 0.1 1.7e-08 34.4 0.1 2.7 1 1 0 1 1 1 1 RecQ-mediated genome instability protein 2 ABC_tran PF00005.27 EFA77179.1 - 1e-54 184.8 0.2 8.8e-31 107.2 0.0 3.0 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFA77179.1 - 4.8e-53 180.6 36.7 1.4e-31 110.2 11.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFA77179.1 - 4.6e-12 45.9 6.8 0.00037 20.0 0.2 4.4 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFA77179.1 - 3.9e-06 26.9 0.6 0.063 13.2 0.1 3.4 3 0 0 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA77179.1 - 2.3e-05 24.5 0.2 0.11 12.5 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA77179.1 - 3.7e-05 23.4 0.7 0.27 11.0 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA77179.1 - 5.5e-05 23.5 0.1 0.37 11.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA77179.1 - 9.9e-05 22.8 0.0 0.16 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFA77179.1 - 0.00017 21.5 8.1 0.023 14.5 0.3 3.8 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 EFA77179.1 - 0.0048 16.6 0.2 0.23 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFA77179.1 - 0.022 14.3 0.0 3.3 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFA77179.1 - 0.079 12.5 0.2 6.8 6.2 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region cobW PF02492.19 EFA77179.1 - 0.11 12.0 3.6 2.2 7.8 0.4 2.8 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EFA77179.1 - 0.15 12.1 0.0 0.15 12.1 0.0 4.0 5 0 0 5 5 4 0 Dynamin family AAA_30 PF13604.6 EFA77179.1 - 0.19 11.5 0.0 25 4.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Connexin PF00029.19 EFA77179.1 - 0.36 10.5 7.2 0.21 11.3 0.1 3.1 3 0 0 3 3 3 0 Connexin RPA43_OB PF17875.1 EFA77179.1 - 0.6 10.7 11.9 0.3 11.7 0.4 3.3 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I ETRAMP PF09716.10 EFA77179.1 - 1 9.4 10.9 4.9 7.3 0.0 3.9 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) ABC_membrane PF00664.23 EFA77180.1 - 8.1e-53 179.8 28.5 3.4e-28 99.1 10.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA77180.1 - 1.9e-43 148.3 0.6 2.6e-20 73.3 0.0 3.7 3 1 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EFA77180.1 - 3.7e-09 36.3 7.3 0.084 12.3 0.0 4.4 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA77180.1 - 6.6e-07 29.4 1.1 0.023 14.5 0.2 3.9 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA77180.1 - 1.4e-06 28.3 0.3 0.32 10.9 0.1 3.4 3 0 0 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA77180.1 - 2.2e-05 24.5 1.3 0.11 12.6 0.0 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EFA77180.1 - 4.1e-05 23.9 0.3 0.14 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFA77180.1 - 7.3e-05 22.4 1.3 0.41 10.4 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA77180.1 - 0.00015 22.2 0.5 0.39 11.1 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain CENP-B_dimeris PF09026.10 EFA77180.1 - 0.0041 17.5 6.6 0.0041 17.5 6.6 3.3 2 1 0 3 3 1 1 Centromere protein B dimerisation domain AAA_24 PF13479.6 EFA77180.1 - 0.0051 16.6 0.4 0.23 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFA77180.1 - 0.026 14.1 0.9 2.1 7.9 0.4 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EFA77180.1 - 0.044 13.8 7.6 0.14 12.2 0.0 3.4 4 0 0 4 4 3 0 Dynamin family AAA_25 PF13481.6 EFA77180.1 - 0.045 13.3 0.0 7.4 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain NOA36 PF06524.12 EFA77180.1 - 0.3 10.3 21.0 0.029 13.7 3.5 2.2 2 0 0 2 2 2 0 NOA36 protein AAA_23 PF13476.6 EFA77180.1 - 0.56 10.7 0.0 0.56 10.7 0.0 4.6 3 1 1 4 4 3 0 AAA domain RNA_pol_3_Rpc31 PF11705.8 EFA77180.1 - 8.8 6.5 27.0 9.8 6.4 14.3 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 ABC_membrane PF00664.23 EFA77181.1 - 6.2e-59 199.9 32.0 1.8e-34 119.7 10.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA77181.1 - 3.4e-43 147.4 0.4 1.2e-30 106.8 0.0 3.7 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA77181.1 - 4.8e-08 32.7 7.3 9.3e-05 22.0 0.2 3.9 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA77181.1 - 9e-06 25.7 0.1 0.047 13.5 0.1 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA77181.1 - 2.4e-05 24.0 1.1 0.16 11.8 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFA77181.1 - 4.1e-05 23.6 0.1 0.094 12.8 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA77181.1 - 8.1e-05 22.6 0.1 0.33 10.9 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFA77181.1 - 0.00035 20.8 0.1 0.95 9.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA77181.1 - 0.00051 20.5 0.0 0.89 9.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 EFA77181.1 - 0.0044 16.8 0.2 0.19 11.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFA77181.1 - 0.012 15.2 0.4 1.2 8.7 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EFA77181.1 - 0.016 14.8 0.0 2.6 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFA77181.1 - 0.08 12.7 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 EFA77181.1 - 0.18 11.1 0.1 19 4.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.6 EFA77181.1 - 0.57 10.7 0.0 0.57 10.7 0.0 4.2 2 1 1 3 3 2 0 AAA domain RPA43_OB PF17875.1 EFA77181.1 - 1 10.0 3.5 8.7 7.0 0.3 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF4637 PF15470.6 EFA77181.1 - 1 9.0 9.3 0.2 11.4 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) RXT2_N PF08595.11 EFA77181.1 - 1.6 8.7 12.6 0.38 10.8 3.8 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal MPP6 PF10175.9 EFA77181.1 - 6.5 7.3 13.2 5.8 7.4 4.5 2.9 2 0 0 2 2 2 0 M-phase phosphoprotein 6 CDC45 PF02724.14 EFA77181.1 - 9.5 4.4 13.5 0.085 11.1 3.3 2.1 2 0 0 2 2 2 0 CDC45-like protein RasGAP PF00616.19 EFA77182.1 - 9.2e-31 107.2 2.2 1.3e-30 106.7 0.0 2.2 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EFA77182.1 - 1.6e-15 57.5 5.4 2.6e-15 56.8 4.0 2.1 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EFA77182.1 - 4.7e-13 49.2 2.8 1.4e-12 47.7 2.8 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain Myosin_TH1 PF06017.13 EFA77182.1 - 1.3e-06 28.2 3.0 0.0091 15.7 1.4 2.4 2 0 0 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding COX5A PF02284.16 EFA77182.1 - 0.11 12.6 0.0 0.37 10.8 0.0 2.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va PDDEXK_10 PF07788.11 EFA77182.1 - 0.13 12.2 0.4 0.5 10.3 0.0 2.2 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily Ras PF00071.22 EFA77183.1 - 1.9e-58 196.6 0.3 2.2e-58 196.4 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA77183.1 - 2.1e-35 121.6 0.2 3.3e-35 120.9 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA77183.1 - 7e-17 61.4 0.2 8.6e-17 61.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA77183.1 - 4.2e-07 30.1 0.3 7.2e-07 29.3 0.1 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFA77183.1 - 7.9e-07 28.7 0.2 9.7e-07 28.4 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFA77183.1 - 4.8e-06 26.2 0.2 1.4e-05 24.8 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFA77183.1 - 3.1e-05 23.6 0.1 9.1e-05 22.0 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA77183.1 - 0.00023 21.1 0.1 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EFA77183.1 - 0.0076 15.7 0.0 0.0093 15.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit CPT PF07931.12 EFA77183.1 - 0.051 13.4 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 EFA77183.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein DUF202 PF02656.15 EFA77184.1 - 8e-08 32.6 6.0 1.2e-07 32.0 6.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF202) PI3K_1B_p101 PF10486.9 EFA77184.1 - 1 7.1 6.3 2 6.1 6.3 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 EFA77184.1 - 2.5 6.3 31.4 0.0047 15.3 20.0 1.9 2 0 0 2 2 2 0 CDC45-like protein RRM_1 PF00076.22 EFA77185.1 - 4.2e-27 93.8 4.2 1.8e-15 56.5 0.1 3.7 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA77185.1 - 0.0013 18.8 0.0 1.9 8.7 0.0 3.0 2 0 0 2 2 2 2 RNA recognition motif BRAP2 PF07576.12 EFA77185.1 - 0.01 16.0 0.0 0.043 14.0 0.0 2.0 2 0 0 2 2 2 0 BRCA1-associated protein 2 Nup35_RRM_2 PF14605.6 EFA77185.1 - 0.066 13.2 0.2 7.8 6.6 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif adh_short PF00106.25 EFA77186.1 - 2.6e-42 144.5 0.0 3.4e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA77186.1 - 1.8e-27 96.4 0.0 2.3e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA77186.1 - 3.9e-07 30.1 0.0 6.2e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFA77186.1 - 0.0001 21.8 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EFA77186.1 - 0.0082 15.7 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EFA77186.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFA77186.1 - 0.032 14.1 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFA77186.1 - 0.04 13.3 0.1 0.055 12.8 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA77186.1 - 0.043 13.3 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFA77186.1 - 0.12 11.5 0.1 0.25 10.5 0.1 1.7 1 1 0 1 1 1 0 Male sterility protein DUF5348 PF17295.2 EFA77186.1 - 0.16 11.9 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) TES PF08034.11 EFA77186.1 - 0.16 12.3 0.9 11 6.4 0.1 2.4 2 0 0 2 2 2 0 Trematode eggshell synthesis protein AMP-binding PF00501.28 EFA77187.1 - 3.4e-28 98.4 0.0 6.7e-28 97.4 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme FPL PF09758.9 EFA77189.1 - 4.7e-25 88.3 1.5 1.1e-24 87.2 1.5 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF4685 PF15737.5 EFA77189.1 - 0.13 12.7 14.2 0.088 13.3 1.5 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4685) S4 PF01479.25 EFA77190.1 - 1.5e-09 37.4 0.5 4.4e-09 35.9 0.5 1.9 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EFA77190.1 - 2.1e-05 25.3 1.0 5.3e-05 24.1 0.2 2.1 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Alg6_Alg8 PF03155.15 EFA77191.1 - 1e-167 559.0 33.2 1.2e-167 558.8 33.2 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Nnf1 PF03980.14 EFA77192.1 - 6.8e-18 65.1 2.9 9.5e-18 64.6 2.3 1.6 1 1 1 2 2 2 1 Nnf1 HALZ PF02183.18 EFA77192.1 - 0.013 15.7 7.4 0.02 15.1 6.4 1.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF948 PF06103.11 EFA77192.1 - 0.048 13.9 2.6 0.11 12.7 0.8 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) KIP1 PF07765.12 EFA77192.1 - 1.6 8.9 5.1 2.5 8.3 0.7 2.9 3 1 0 3 3 3 0 KIP1-like protein Radical_SAM PF04055.21 EFA77193.1 - 6.5e-14 52.6 0.0 1.5e-13 51.5 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EFA77193.1 - 2.8e-05 24.2 0.0 8.1e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 EFA77193.1 - 0.00036 20.8 0.0 0.00081 19.7 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain AnmK PF03702.14 EFA77194.1 - 1.2e-142 475.3 0.0 1.4e-142 475.1 0.0 1.0 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase Pkinase PF00069.25 EFA77196.1 - 1.6e-40 139.2 0.0 5.9e-28 98.0 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77196.1 - 1.4e-19 70.5 0.0 1.1e-14 54.3 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Tetraspanin PF00335.20 EFA77196.1 - 0.0071 16.1 1.7 0.0096 15.7 1.7 1.2 1 0 0 1 1 1 1 Tetraspanin family RTA1 PF04479.13 EFA77197.1 - 2.5e-20 73.0 18.1 8e-20 71.3 18.1 1.8 1 1 0 1 1 1 1 RTA1 like protein DUF2569 PF10754.9 EFA77197.1 - 0.04 14.4 15.1 0.068 13.6 8.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF4293 PF14126.6 EFA77197.1 - 2.8 8.2 17.6 0.077 13.2 8.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) PolyA_pol PF01743.20 EFA77198.1 - 3.1e-30 105.2 1.4 3.5e-30 105.0 0.2 1.8 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EFA77198.1 - 1.2e-05 24.9 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EFA77198.1 - 0.014 15.4 0.0 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative Acetyltransf_9 PF13527.7 EFA77199.1 - 1.8e-08 34.5 0.2 9.2e-08 32.2 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA77199.1 - 1.8e-05 25.1 0.0 3.1e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA77199.1 - 3.6e-05 24.0 0.0 7.1e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA77199.1 - 0.00018 21.5 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Anillin PF08174.11 EFA77199.1 - 0.066 13.6 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 Cell division protein anillin Acetyltransf_13 PF13880.6 EFA77199.1 - 0.08 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase PKcGMP_CC PF16808.5 EFA77201.1 - 4.3e-06 26.5 10.3 8.3e-05 22.4 0.8 3.5 2 1 2 4 4 4 3 Coiled-coil N-terminus of cGMP-dependent protein kinase FPP PF05911.11 EFA77201.1 - 5e-05 21.7 18.3 6e-05 21.5 18.3 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.8 EFA77201.1 - 0.00032 20.9 15.0 0.00032 20.9 15.0 2.0 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding MAD PF05557.13 EFA77201.1 - 0.0014 17.1 20.1 0.0018 16.7 20.1 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Fez1 PF06818.15 EFA77201.1 - 0.0019 18.7 16.6 0.0033 17.9 16.6 1.4 1 0 0 1 1 1 1 Fez1 DUF812 PF05667.11 EFA77201.1 - 0.002 17.1 16.1 0.0025 16.8 16.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Exonuc_VII_L PF02601.15 EFA77201.1 - 0.0021 17.7 13.8 0.003 17.2 13.8 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit FlaC_arch PF05377.11 EFA77201.1 - 0.0026 18.1 11.1 0.25 11.8 3.3 3.3 2 1 0 3 3 2 2 Flagella accessory protein C (FlaC) HMMR_N PF15905.5 EFA77201.1 - 0.0054 16.3 23.2 0.0092 15.5 23.2 1.4 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 EFA77201.1 - 0.014 14.3 25.0 0.044 12.7 25.0 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 EFA77201.1 - 0.022 15.3 16.4 1.7 9.3 5.6 3.3 1 1 2 3 3 3 0 Syntaxin 6, N-terminal ATG16 PF08614.11 EFA77201.1 - 0.027 14.7 20.8 0.044 14.0 20.8 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 EFA77201.1 - 0.06 12.7 12.7 0.091 12.1 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM76 PF16046.5 EFA77201.1 - 0.086 12.2 17.4 0.038 13.3 15.4 1.5 2 0 0 2 2 1 0 FAM76 protein Csm1_N PF18504.1 EFA77201.1 - 0.095 13.1 24.9 0.25 11.7 3.9 3.8 2 1 2 4 4 3 0 Csm1 N-terminal domain DUF641 PF04859.12 EFA77201.1 - 0.1 12.9 19.3 0.35 11.2 13.8 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4618 PF15397.6 EFA77201.1 - 0.11 11.9 24.1 0.37 10.2 24.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) FliD_N PF02465.18 EFA77201.1 - 0.14 12.8 16.7 0.2 12.3 2.6 3.0 2 1 1 3 3 2 0 Flagellar hook-associated protein 2 N-terminus Presenilin PF01080.17 EFA77201.1 - 0.21 10.3 6.3 0.29 9.9 6.3 1.1 1 0 0 1 1 1 0 Presenilin Gp_dh_N PF00044.24 EFA77201.1 - 0.22 11.9 2.6 23 5.4 1.3 2.8 2 1 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Tweety PF04906.13 EFA77201.1 - 0.23 10.1 6.0 0.31 9.7 6.0 1.3 1 0 0 1 1 1 0 Tweety HOOK PF05622.12 EFA77201.1 - 0.23 9.5 27.5 0.17 10.0 16.3 1.9 1 1 1 2 2 2 0 HOOK protein Laminin_II PF06009.12 EFA77201.1 - 0.28 11.2 19.0 1.4 8.9 16.4 2.5 1 1 2 3 3 3 0 Laminin Domain II DUF3552 PF12072.8 EFA77201.1 - 0.29 10.5 23.2 0.18 11.2 20.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Phage_GP20 PF06810.11 EFA77201.1 - 0.33 10.7 17.5 0.88 9.4 16.0 2.5 1 1 0 1 1 1 0 Phage minor structural protein GP20 HrpB7 PF09486.10 EFA77201.1 - 0.6 10.5 7.9 7.5 6.9 0.5 1.9 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) MPS2 PF17060.5 EFA77201.1 - 0.75 9.0 20.1 0.6 9.3 7.0 2.3 1 1 1 2 2 2 0 Monopolar spindle protein 2 Phage_GPO PF05929.11 EFA77201.1 - 0.98 9.0 16.6 2.2 7.8 16.4 1.6 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF2203 PF09969.9 EFA77201.1 - 1.1 10.0 12.5 2.9 8.6 5.4 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) L31 PF09784.9 EFA77201.1 - 1.2 9.6 8.6 1.1 9.7 5.3 2.5 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 HemX PF04375.14 EFA77201.1 - 1.2 8.3 25.8 0.58 9.4 22.8 1.8 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase Sec34 PF04136.15 EFA77201.1 - 1.4 8.8 19.3 1.1 9.1 12.9 2.7 2 1 1 3 3 2 0 Sec34-like family ALMT PF11744.8 EFA77201.1 - 1.4 7.6 11.1 1.8 7.3 11.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Suppressor_APC PF11414.8 EFA77201.1 - 1.7 8.8 16.2 3.6 7.7 4.8 2.7 1 1 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Spectrin PF00435.21 EFA77201.1 - 1.8 9.1 23.9 3.1 8.3 8.7 2.5 1 1 1 2 2 2 0 Spectrin repeat DUF724 PF05266.14 EFA77201.1 - 1.9 8.3 19.4 3.9 7.3 17.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TMF_DNA_bd PF12329.8 EFA77201.1 - 2.2 8.3 27.0 7.9 6.6 15.5 3.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding TRAF_BIRC3_bd PF16673.5 EFA77201.1 - 2.7 7.9 8.5 1.7 8.5 4.2 2.8 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain ABC_tran_CTD PF16326.5 EFA77201.1 - 2.7 8.3 15.9 2.3 8.5 7.1 3.4 1 1 2 3 3 3 0 ABC transporter C-terminal domain MbeD_MobD PF04899.12 EFA77201.1 - 3.1 8.0 14.5 1.1 9.4 6.2 2.7 1 1 1 2 2 2 0 MbeD/MobD like UPF0242 PF06785.11 EFA77201.1 - 3.1 7.9 29.4 6.6 6.8 18.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 EFA77201.1 - 3.3 5.5 15.7 4.4 5.1 15.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BLOC1_2 PF10046.9 EFA77201.1 - 3.6 8.0 19.2 6.9 7.0 10.0 3.1 1 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GvpK PF05121.12 EFA77201.1 - 3.8 7.6 8.7 1.7 8.7 0.4 2.7 1 1 1 2 2 2 0 Gas vesicle protein K DUF3450 PF11932.8 EFA77201.1 - 3.9 6.7 22.5 7.8 5.7 19.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF2730 PF10805.8 EFA77201.1 - 3.9 7.6 12.8 3.9 7.6 7.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) FapA PF03961.13 EFA77201.1 - 4 5.9 21.6 22 3.5 21.6 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A SlyX PF04102.12 EFA77201.1 - 4.3 8.0 25.4 8.9 7.0 9.5 3.5 2 1 2 4 4 3 0 SlyX DUF948 PF06103.11 EFA77201.1 - 5.1 7.4 12.2 15 5.9 8.9 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Med9 PF07544.13 EFA77201.1 - 5.3 7.2 22.4 16 5.7 20.0 2.9 1 1 1 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 Uds1 PF15456.6 EFA77201.1 - 6.9 6.8 19.7 5.5 7.2 2.5 2.8 2 1 1 3 3 2 0 Up-regulated During Septation DUF1664 PF07889.12 EFA77201.1 - 7.2 6.7 15.4 7.7 6.6 11.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 EFA77201.1 - 9 5.3 23.4 1.3 8.0 12.9 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 EFA77201.1 - 9.6 6.5 25.9 4.6e+02 1.1 25.9 2.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Rho_N PF07498.12 EFA77202.1 - 0.03 14.3 1.4 0.11 12.5 1.4 1.9 1 1 0 1 1 1 0 Rho termination factor, N-terminal domain GST_C_3 PF14497.6 EFA77203.1 - 8.3e-19 67.6 0.6 1.4e-18 66.9 0.1 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA77203.1 - 3.3e-10 40.1 0.0 6.6e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA77203.1 - 2.1e-09 37.5 0.1 4.4e-09 36.5 0.1 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA77203.1 - 1.6e-07 31.2 0.0 2.2e-06 27.6 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA77203.1 - 0.0018 18.0 0.1 0.0037 17.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA77203.1 - 0.015 15.7 0.1 0.21 12.0 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Unstab_antitox PF09720.10 EFA77204.1 - 0.0026 17.8 0.3 0.0061 16.6 0.3 1.7 1 0 0 1 1 1 1 Putative addiction module component TatD_DNase PF01026.21 EFA77205.1 - 1.3e-60 204.9 0.0 1.6e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase DUF4106 PF13388.6 EFA77205.1 - 0.87 8.7 8.0 1.8 7.7 8.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Acetyltransf_2 PF00797.17 EFA77208.1 - 9.2e-34 117.3 0.0 1.2e-33 117.0 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 EFA77209.1 - 2e-22 80.2 0.0 3.8e-20 72.7 0.0 2.1 1 1 1 2 2 2 2 N-acetyltransferase MFS_1 PF07690.16 EFA77210.1 - 3.8e-33 114.9 37.5 4.4e-27 94.9 33.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA77210.1 - 2.7e-08 33.1 12.5 2.7e-08 33.1 12.5 3.4 2 1 1 3 3 3 2 Sugar (and other) transporter BT1 PF03092.16 EFA77210.1 - 0.0088 14.3 9.1 0.14 10.3 2.1 3.1 3 0 0 3 3 3 2 BT1 family MFS_3 PF05977.13 EFA77210.1 - 0.15 10.4 12.9 0.019 13.3 5.3 2.1 1 1 1 2 2 2 0 Transmembrane secretion effector FtsL PF04999.13 EFA77210.1 - 0.64 10.0 2.3 28 4.8 0.8 3.1 3 0 0 3 3 3 0 Cell division protein FtsL eIF-5_eIF-2B PF01873.17 EFA77211.1 - 4.8e-37 126.4 0.1 9.6e-37 125.4 0.1 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EFA77211.1 - 1.9e-21 75.9 0.8 1.9e-21 75.9 0.8 3.3 3 1 1 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon HSR PF03172.13 EFA77211.1 - 0.04 14.1 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 HSR domain Myc_N PF01056.18 EFA77211.1 - 0.69 9.8 10.3 1.4 8.7 0.3 2.2 2 0 0 2 2 2 0 Myc amino-terminal region FYDLN_acid PF09538.10 EFA77211.1 - 8 7.2 17.2 1.2 9.8 3.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) 2OG-FeII_Oxy_2 PF13532.6 EFA77212.1 - 6.3e-15 55.9 0.0 1.3e-14 54.8 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFA77212.1 - 0.027 15.0 0.0 0.06 13.8 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Pcc1 PF09341.10 EFA77213.1 - 1.6e-12 47.4 0.0 2.1e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Transcription factor Pcc1 Pox_MCEL PF03291.16 EFA77214.1 - 1.1e-31 110.2 0.1 1.3e-31 110.0 0.1 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EFA77214.1 - 2.5e-09 37.7 0.0 3.7e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA77214.1 - 1.9e-07 31.0 0.0 2.4e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA77214.1 - 2.2e-05 25.0 0.0 3.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77214.1 - 4.6e-05 24.1 0.0 6.8e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Strumpellin PF10266.9 EFA77215.1 - 0 1119.2 17.0 0 1119.0 17.0 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin NOD PF06816.13 EFA77215.1 - 0.079 12.6 2.5 4.8 6.9 0.3 3.8 3 1 0 3 3 3 0 NOTCH protein Strumpellin PF10266.9 EFA77216.1 - 3.8e-108 362.7 1.5 4.3e-108 362.5 1.5 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Pkinase PF00069.25 EFA77217.1 - 1.8e-65 221.0 0.0 1.8e-65 221.0 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain TPR_17 PF13431.6 EFA77217.1 - 1.6e-62 203.5 15.3 1e-08 34.9 0.1 10.5 10 0 0 10 10 10 9 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 EFA77217.1 - 2.7e-45 154.7 0.0 6.2e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Acyltransf_C PF16076.5 EFA77217.1 - 2.4e-15 56.4 0.1 7e-15 54.9 0.1 1.8 1 0 0 1 1 1 1 Acyltransferase C-terminus PBD PF00786.28 EFA77217.1 - 8.2e-15 54.9 0.3 4.3e-14 52.6 0.3 2.4 1 0 0 1 1 1 1 P21-Rho-binding domain Acyltransferase PF01553.21 EFA77217.1 - 1.2e-13 50.9 0.0 7.7e-13 48.2 0.0 2.4 3 0 0 3 3 3 1 Acyltransferase TPR_11 PF13414.6 EFA77217.1 - 4.3e-13 48.7 30.6 0.0021 17.7 0.3 10.0 10 0 0 10 10 10 5 TPR repeat Anth_Ig PF05587.13 EFA77217.1 - 0.15 12.4 3.4 30 5.0 0.0 4.6 4 1 0 5 5 5 0 Anthrax receptor extracellular domain PIP5K PF01504.18 EFA77218.1 - 0.42 9.8 7.5 0.8 8.9 3.1 2.6 2 1 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Lactamase_B_2 PF12706.7 EFA77219.1 - 5.2e-36 124.1 0.0 6.8e-36 123.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFA77219.1 - 1.9e-16 60.4 0.0 2.6e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain YwhD PF08741.10 EFA77219.1 - 0.078 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 YwhD family Lactamase_B PF00753.27 EFA77219.1 - 0.088 12.8 1.3 0.2 11.7 1.3 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Pacs-1 PF10254.9 EFA77220.1 - 2.6e-31 109.0 0.1 2.6e-31 109.0 0.1 4.2 3 2 0 3 3 3 1 PACS-1 cytosolic sorting protein RNA_pol_L_2 PF13656.6 EFA77220.1 - 9.5e-24 83.0 0.1 2.2e-23 81.8 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFA77220.1 - 0.0085 15.5 0.0 0.023 14.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PI3K_1B_p101 PF10486.9 EFA77220.1 - 0.71 7.6 21.0 8.5 4.0 20.4 2.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GATA PF00320.27 EFA77221.1 - 6.8e-16 57.6 3.1 1.5e-15 56.4 3.1 1.7 1 0 0 1 1 1 1 GATA zinc finger ER-remodelling PF14755.6 EFA77221.1 - 0.2 11.9 1.9 0.35 11.1 0.4 2.0 2 0 0 2 2 2 0 Intracellular membrane remodeller PHD PF00628.29 EFA77222.1 - 1e-10 41.3 11.6 3.2e-10 39.7 7.0 2.5 2 0 0 2 2 2 1 PHD-finger SR-25 PF10500.9 EFA77222.1 - 0.00041 20.0 15.4 0.00041 20.0 15.4 4.7 4 1 1 5 5 5 1 Nuclear RNA-splicing-associated protein zf-HC5HC2H PF13771.6 EFA77222.1 - 0.0059 16.8 1.3 0.014 15.6 1.3 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain FYVE_2 PF02318.16 EFA77222.1 - 0.24 11.6 1.6 0.33 11.2 0.4 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger zf-4CXXC_R1 PF10497.9 EFA77222.1 - 2.6 8.3 8.5 20 5.5 0.1 2.6 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DNA_topoisoIV PF00521.20 EFA77223.1 - 1.9e-112 376.3 0.9 3.2e-112 375.6 0.9 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFA77223.1 - 8.2e-44 149.0 4.1 8.2e-44 149.0 4.1 2.3 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFA77223.1 - 3.7e-22 78.6 0.2 3.7e-22 78.6 0.2 2.3 3 0 0 3 3 3 1 DNA gyrase B HATPase_c PF02518.26 EFA77223.1 - 1.3e-10 41.8 0.0 3.8e-10 40.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EFA77223.1 - 4.8e-07 30.0 0.0 1.5e-06 28.4 0.0 1.9 1 0 0 1 1 1 1 Toprim domain MitMem_reg PF13012.6 EFA77224.1 - 9.1e-29 100.1 0.1 2.5e-28 98.7 0.0 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFA77224.1 - 4.5e-23 81.5 0.1 8e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ribosomal_L23 PF00276.20 EFA77226.1 - 3.9e-15 56.0 4.4 5.1e-15 55.6 4.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 DUF2723 PF11028.8 EFA77227.1 - 1.7e-38 132.2 9.1 3.7e-38 131.1 9.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) IPK PF03770.16 EFA77228.1 - 4.2e-39 134.5 0.0 7.7e-39 133.6 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Macoilin PF09726.9 EFA77228.1 - 0.018 13.7 1.7 0.023 13.3 1.7 1.2 1 0 0 1 1 1 0 Macoilin family IMUP PF15761.5 EFA77228.1 - 0.38 11.5 3.4 0.89 10.3 3.4 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein NTP_transf_2 PF01909.23 EFA77229.1 - 4.5e-07 30.1 0.2 3.5e-06 27.2 0.0 2.6 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFA77229.1 - 0.0095 16.0 0.0 0.0095 16.0 0.0 3.1 3 0 0 3 3 3 1 Polymerase beta, Nucleotidyltransferase RabGAP-TBC PF00566.18 EFA77230.1 - 4.7e-53 180.0 0.1 4.7e-53 180.0 0.1 2.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Transket_pyr PF02779.24 EFA77230.1 - 2.2e-46 157.7 0.0 8.6e-46 155.8 0.0 2.0 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFA77230.1 - 1.5e-33 115.3 0.0 2.8e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain GRAM PF02893.20 EFA77230.1 - 1.9e-11 43.8 1.5 4.9e-09 36.1 0.5 2.6 2 0 0 2 2 2 2 GRAM domain PFOR_II PF17147.4 EFA77230.1 - 0.031 14.6 0.0 0.07 13.4 0.0 1.6 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II NAD_binding_6 PF08030.12 EFA77230.1 - 0.06 13.5 0.5 15 5.7 0.0 2.8 3 0 0 3 3 3 0 Ferric reductase NAD binding domain bPH_2 PF03703.14 EFA77230.1 - 0.13 12.5 0.0 19 5.5 0.0 2.5 2 0 0 2 2 2 0 Bacterial PH domain SR-25 PF10500.9 EFA77233.1 - 0.00073 19.2 16.5 0.00073 19.2 16.5 3.6 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein Myb_DNA-binding PF00249.31 EFA77233.1 - 0.0086 16.2 0.5 0.017 15.3 0.5 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain MTBP_mid PF14919.6 EFA77233.1 - 0.012 14.8 4.1 0.016 14.4 3.3 1.5 1 1 0 1 1 1 0 MDM2-binding Myb_DNA-bind_6 PF13921.6 EFA77233.1 - 0.013 15.8 0.5 0.044 14.0 0.5 2.0 1 0 0 1 1 1 0 Myb-like DNA-binding domain LolB PF03550.14 EFA77233.1 - 0.022 14.8 0.8 0.063 13.3 0.7 1.9 1 1 0 1 1 1 0 Outer membrane lipoprotein LolB COesterase PF00135.28 EFA77234.1 - 1.5e-116 390.3 0.0 2e-116 389.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA77234.1 - 1.7e-05 24.8 0.0 4.2e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pyridoxal_deC PF00282.19 EFA77235.1 - 2e-16 59.7 0.0 8.1e-16 57.7 0.0 1.9 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EFA77235.1 - 4.2e-07 29.2 0.0 2.8e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFA77235.1 - 6.3e-05 22.3 0.0 0.00091 18.5 0.0 2.3 2 1 0 2 2 2 1 Aminotransferase class I and II He_PIG PF05345.12 EFA77236.1 - 0.021 15.0 0.1 2.9 8.1 0.0 2.6 2 0 0 2 2 2 0 Putative Ig domain Orf78 PF06024.12 EFA77236.1 - 0.083 13.2 0.2 0.2 12.0 0.2 1.7 1 0 0 1 1 1 0 Orf78 (ac78) DnaJ PF00226.31 EFA77237.1 - 2e-13 50.2 1.7 1.3e-12 47.7 1.7 2.5 1 0 0 1 1 1 1 DnaJ domain Chromo PF00385.24 EFA77237.1 - 1.2e-12 47.5 1.8 1.2e-12 47.5 1.8 3.3 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain AP3B1_C PF14796.6 EFA77240.1 - 0.08 13.2 0.2 0.13 12.5 0.2 1.4 1 1 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal AMP-binding PF00501.28 EFA77241.1 - 1.4e-90 303.9 0.0 1.7e-90 303.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA77241.1 - 1.4e-05 25.9 0.1 6.5e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Methyltr_RsmB-F PF01189.17 EFA77242.1 - 7.4e-74 247.7 0.0 1.2e-73 247.0 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EFA77242.1 - 3.2e-11 43.6 0.0 9.7e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 EFA77242.1 - 2e-05 24.4 0.0 3.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein FtsJ PF01728.19 EFA77242.1 - 5.4e-05 23.4 0.1 9.1e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 EFA77242.1 - 0.00072 19.4 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 EFA77242.1 - 0.0087 16.7 0.0 0.019 15.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain AAR2 PF05282.11 EFA77242.1 - 0.076 12.4 5.9 0.11 11.9 5.9 1.3 1 0 0 1 1 1 0 AAR2 protein Macoilin PF09726.9 EFA77242.1 - 0.15 10.6 13.3 0.18 10.3 13.3 1.2 1 0 0 1 1 1 0 Macoilin family GCD14 PF08704.10 EFA77242.1 - 0.16 11.6 6.9 7.3 6.2 7.3 2.4 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Presenilin PF01080.17 EFA77242.1 - 0.85 8.3 15.6 1.2 7.8 15.6 1.1 1 0 0 1 1 1 0 Presenilin Folliculin PF11704.8 EFA77242.1 - 1.1 9.1 7.6 2.3 8.1 7.6 1.5 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport CDC45 PF02724.14 EFA77242.1 - 2.2 6.5 16.2 3.1 6.0 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Gti1_Pac2 PF09729.9 EFA77242.1 - 2.8 8.0 15.4 6.7 6.8 14.7 1.8 2 0 0 2 2 2 0 Gti1/Pac2 family DUF853 PF05872.12 EFA77242.1 - 4.5 5.8 7.5 1.4 7.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) SID-1_RNA_chan PF13965.6 EFA77242.1 - 7.4 4.9 6.9 9.1 4.6 6.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 zf-RING_2 PF13639.6 EFA77244.1 - 8.1e-10 38.9 7.6 2.3e-09 37.4 7.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFA77244.1 - 1.6e-08 34.1 4.1 4e-08 32.9 4.1 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EFA77244.1 - 1.9e-06 27.6 4.9 2.9e-06 27.0 3.5 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA77244.1 - 5.1e-06 26.7 6.2 5.1e-06 26.7 6.2 2.5 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFA77244.1 - 9.5e-06 25.4 7.3 2.6e-05 24.0 7.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EFA77244.1 - 2.4e-05 23.9 2.6 4.9e-05 22.9 2.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EFA77244.1 - 0.00031 20.6 1.5 0.00031 20.6 1.5 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EFA77244.1 - 0.00063 19.8 4.0 0.0015 18.6 4.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFA77244.1 - 0.0023 17.9 5.6 0.0066 16.5 5.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.7 EFA77244.1 - 0.016 15.3 2.0 0.047 13.8 2.0 1.8 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EFA77244.1 - 0.03 14.1 3.1 0.12 12.2 3.1 2.1 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TFIIA PF03153.13 EFA77244.1 - 0.43 10.5 47.5 0.76 9.7 47.1 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FANCL_C PF11793.8 EFA77244.1 - 0.81 9.9 6.8 0.23 11.7 2.5 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain Haspin_kinase PF12330.8 EFA77245.1 - 1.4e-06 27.5 0.1 1.4e-06 27.5 0.1 3.2 3 1 0 3 3 3 1 Haspin like kinase domain Sigma70_ner PF04546.13 EFA77245.1 - 6 6.7 23.5 0.26 11.1 6.6 2.5 2 1 0 2 2 2 0 Sigma-70, non-essential region Mucin PF01456.17 EFA77245.1 - 6.7 6.7 27.0 17 5.4 27.0 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein BUD22 PF09073.10 EFA77245.1 - 9.8 5.4 34.7 0.034 13.5 8.4 2.4 1 1 1 2 2 2 0 BUD22 GTP_EFTU PF00009.27 EFA77246.1 - 1.4e-61 207.4 0.1 2.3e-61 206.7 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFA77246.1 - 1.3e-36 125.0 0.0 2.7e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EFA77246.1 - 1.5e-32 111.5 0.1 6.4e-32 109.5 0.0 2.2 2 0 0 2 2 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFA77246.1 - 2.9e-25 88.1 0.1 7.1e-25 86.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFA77246.1 - 2.1e-12 47.2 0.1 5.5e-12 45.9 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFA77246.1 - 2.8e-06 27.2 0.1 5.8e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFA77246.1 - 0.00082 19.4 0.1 0.0017 18.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF442 PF04273.13 EFA77246.1 - 0.00094 19.2 0.0 7.3 6.7 0.0 3.3 3 0 0 3 3 3 1 Putative phosphatase (DUF442) AglB_L1 PF18079.1 EFA77246.1 - 0.006 16.8 1.0 0.17 12.2 0.1 3.2 3 0 0 3 3 3 1 Archaeal glycosylation protein B long peripheral domain AIG1 PF04548.16 EFA77246.1 - 0.021 14.1 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 AIG1 family SUI1 PF01253.22 EFA77246.1 - 0.024 15.1 0.0 0.064 13.8 0.0 1.7 1 0 0 1 1 1 0 Translation initiation factor SUI1 VWA_N PF08399.11 EFA77246.1 - 0.14 12.6 0.2 0.36 11.3 0.1 1.8 2 0 0 2 2 1 0 VWA N-terminal CxC6 PF18721.1 EFA77247.1 - 0.011 15.9 0.5 0.015 15.5 0.5 1.3 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases DUF4710 PF15828.5 EFA77247.1 - 0.019 15.0 1.5 0.025 14.7 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) WRC PF08879.10 EFA77247.1 - 0.032 13.9 0.8 0.053 13.2 0.8 1.3 1 0 0 1 1 1 0 WRC Fn3_assoc PF13287.6 EFA77249.1 - 9.8e-14 51.3 11.8 2.1e-13 50.2 11.8 1.6 1 0 0 1 1 1 1 Fn3 associated CHB_HEX_C_1 PF13290.6 EFA77249.1 - 1.9e-11 43.8 11.4 4.8e-11 42.5 11.4 1.7 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain tRNA_synthFbeta PF17759.1 EFA77250.1 - 2.8e-48 164.2 0.0 3.9e-48 163.7 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EFA77250.1 - 4.1e-31 107.0 0.6 6e-30 103.3 0.1 2.6 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EFA77250.1 - 1.4e-26 93.2 0.9 6.5e-26 91.0 0.1 2.1 2 0 0 2 2 2 1 B3/4 domain B5 PF03484.15 EFA77250.1 - 5.9e-22 77.7 0.1 2e-18 66.5 0.0 3.1 3 0 0 3 3 3 2 tRNA synthetase B5 domain PhoLip_ATPase_N PF16209.5 EFA77251.1 - 9.5e-25 86.1 3.5 2.2e-24 84.9 3.5 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFA77251.1 - 2.2e-10 40.4 0.0 5.6e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase zf-NF-X1 PF01422.17 EFA77251.1 - 0.16 12.1 0.2 0.26 11.4 0.2 1.3 1 0 0 1 1 1 0 NF-X1 type zinc finger PhoLip_ATPase_C PF16212.5 EFA77252.1 - 1e-75 254.7 34.7 1.5e-75 254.2 34.7 1.2 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EFA77252.1 - 7.8e-13 48.3 0.0 2.6e-11 43.4 0.0 2.7 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA77252.1 - 2.5e-05 24.7 0.0 0.13 12.5 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA77252.1 - 0.00029 20.7 0.0 0.0013 18.6 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase AAA PF00004.29 EFA77253.1 - 3.4e-19 69.6 0.2 8.2e-19 68.3 0.0 1.7 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EFA77253.1 - 5.7e-12 46.0 0.0 1.3e-11 44.8 0.0 1.5 2 0 0 2 2 2 1 BCS1 N terminal AAA_7 PF12775.7 EFA77253.1 - 0.0023 17.5 0.0 0.0038 16.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 EFA77253.1 - 0.0029 17.6 0.0 0.0057 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EFA77253.1 - 0.0074 16.7 0.0 2.3 8.7 0.0 3.1 3 0 0 3 3 3 1 RNA helicase RuvB_N PF05496.12 EFA77253.1 - 0.0079 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Myosin_TH1 PF06017.13 EFA77253.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding AAA_25 PF13481.6 EFA77253.1 - 0.035 13.7 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFA77253.1 - 0.038 13.8 0.0 0.079 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_6 PF12774.7 EFA77253.1 - 0.087 11.8 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region IstB_IS21 PF01695.17 EFA77253.1 - 0.17 11.6 0.2 1.2 8.8 0.2 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 EFA77253.1 - 0.18 12.2 0.4 1.5 9.2 0.1 2.4 3 0 0 3 3 3 0 AAA ATPase domain ApbE PF02424.15 EFA77255.1 - 0.14 11.6 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 ApbE family NUDE_C PF04880.13 EFA77256.1 - 0.1 13.1 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Pkinase PF00069.25 EFA77258.1 - 1.1e-21 77.4 0.4 5.9e-10 39.0 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77258.1 - 7.9e-14 51.6 0.8 7.1e-09 35.3 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase DUF3439 PF11921.8 EFA77258.1 - 0.03 14.3 13.6 0.08 12.9 13.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FAD_binding_1 PF00667.20 EFA77259.1 - 1.1e-29 103.7 2.1 2e-29 102.7 2.1 1.4 1 0 0 1 1 1 1 FAD binding domain Oxidored-like PF09791.9 EFA77259.1 - 6.8e-14 51.3 6.0 7.1e-14 51.2 3.6 2.2 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal NAD_binding_1 PF00175.21 EFA77259.1 - 4.7e-13 49.7 0.0 4.7e-13 49.7 0.0 2.8 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain RcpC PF16976.5 EFA77259.1 - 0.095 12.7 0.2 0.095 12.7 0.2 2.5 3 0 0 3 3 3 0 Flp pilus assembly protein RcpC/CpaB SUIM_assoc PF16619.5 EFA77259.1 - 0.32 11.1 14.0 0.27 11.3 2.4 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF5522 PF17653.1 EFA77259.1 - 0.37 10.8 3.1 0.95 9.5 3.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5522) Piwi PF02171.17 EFA77260.1 - 4.6e-74 249.4 0.3 7.7e-74 248.6 0.3 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EFA77260.1 - 5.5e-24 84.5 0.3 1.3e-23 83.3 0.3 1.6 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 EFA77260.1 - 9.4e-06 25.2 0.0 2.5e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 EFA77260.1 - 0.00017 22.2 0.4 0.00041 21.0 0.4 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute Trypan_PARP PF05887.11 EFA77260.1 - 9 6.3 8.5 4 7.4 5.1 2.0 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DNA_pol_B PF00136.21 EFA77261.1 - 4e-119 398.3 0.1 4e-119 398.3 0.1 2.1 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFA77261.1 - 7.2e-35 120.7 0.0 2e-34 119.3 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 EFA77261.1 - 4.4e-28 98.3 7.9 4.4e-28 98.3 7.9 2.4 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger DNA_pol_alpha_N PF12254.8 EFA77261.1 - 0.0092 16.0 14.2 0.0092 16.0 14.2 4.1 4 0 0 4 4 4 1 DNA polymerase alpha subunit p180 N terminal Allantoicase PF03561.15 EFA77262.1 - 6e-99 327.9 0.0 1.2e-49 168.0 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat Ribosomal_L6 PF00347.23 EFA77263.1 - 1.4e-24 86.6 2.2 2.7e-15 56.8 0.2 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 ADK PF00406.22 EFA77264.1 - 6.5e-47 159.4 0.0 8.9e-47 159.0 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFA77264.1 - 2.7e-23 82.9 0.0 4.8e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EFA77264.1 - 4.6e-15 55.3 0.3 1.6e-14 53.6 0.0 2.0 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EFA77264.1 - 6.1e-08 32.9 0.0 3.9e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA77264.1 - 5e-05 23.8 0.0 0.00012 22.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EFA77264.1 - 0.01 15.5 1.9 3.8 7.2 0.0 2.9 1 1 2 3 3 3 0 Thymidylate kinase dNK PF01712.19 EFA77264.1 - 0.076 12.9 0.7 0.64 9.8 0.0 2.6 2 1 1 3 3 3 0 Deoxynucleoside kinase AAA_28 PF13521.6 EFA77264.1 - 0.098 12.9 0.0 0.18 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Hydin_ADK PF17213.3 EFA77264.1 - 1.5 9.1 0.0 1.5 9.1 0.0 2.5 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Macoilin PF09726.9 EFA77264.1 - 1.9 7.0 7.6 2.7 6.4 7.6 1.2 1 0 0 1 1 1 0 Macoilin family Na_H_Exchanger PF00999.21 EFA77265.1 - 1.3e-57 195.3 50.0 2.1e-57 194.7 50.0 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TraB PF01963.17 EFA77266.1 - 1.5e-17 64.4 0.0 6.3e-17 62.3 0.0 1.8 1 1 0 1 1 1 1 TraB family PrpR_N PF06506.11 EFA77266.1 - 0.0051 16.4 0.0 0.021 14.4 0.0 1.9 2 0 0 2 2 2 1 Propionate catabolism activator ENTH PF01417.20 EFA77266.1 - 0.0082 16.2 1.4 0.021 14.9 0.2 2.1 2 1 0 2 2 2 1 ENTH domain Methyltransf_23 PF13489.6 EFA77266.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF92 PF01940.16 EFA77266.1 - 0.19 11.1 0.2 1.6 8.1 0.1 2.0 2 0 0 2 2 2 0 Integral membrane protein DUF92 RRM_1 PF00076.22 EFA77267.1 - 9e-05 22.2 0.0 0.00025 20.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Menin PF05053.13 EFA77267.1 - 2.7 6.3 10.9 3.1 6.0 10.9 1.2 1 0 0 1 1 1 0 Menin CPBP PF02517.16 EFA77268.1 - 2.1e-17 63.3 4.1 2.1e-17 63.3 4.1 1.9 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Amnionless PF14828.6 EFA77268.1 - 0.019 13.8 6.5 0.035 12.9 6.5 1.4 1 0 0 1 1 1 0 Amnionless RAMP4 PF06624.12 EFA77268.1 - 0.2 11.7 0.1 0.2 11.7 0.1 3.3 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 AF-4 PF05110.13 EFA77268.1 - 2.1 6.3 17.2 2.7 6.0 17.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Mito_carr PF00153.27 EFA77269.1 - 8e-48 160.3 4.7 2.3e-18 65.9 0.3 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein Rhomboid PF01694.22 EFA77269.1 - 2.5e-34 118.4 16.6 2.5e-34 118.4 16.6 2.5 2 0 0 2 2 2 1 Rhomboid family PT-VENN PF04829.13 EFA77269.1 - 0.01 15.9 0.5 0.027 14.5 0.5 1.7 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif DUF1751 PF08551.10 EFA77269.1 - 0.33 11.5 0.1 0.33 11.5 0.1 2.7 3 0 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) DEAD PF00270.29 EFA77270.1 - 5.1e-42 143.6 1.3 1.1e-41 142.5 1.3 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ank_2 PF12796.7 EFA77270.1 - 3.1e-39 133.4 9.7 7.2e-05 23.3 0.0 8.5 4 2 2 8 8 8 8 Ankyrin repeats (3 copies) Helicase_C PF00271.31 EFA77270.1 - 1.2e-32 112.6 1.4 2.3e-31 108.4 0.3 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Ank_4 PF13637.6 EFA77270.1 - 1e-26 92.9 12.1 5.6e-05 23.6 0.1 12.9 7 4 7 14 14 14 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77270.1 - 5.9e-20 71.1 5.6 0.048 14.0 0.1 13.4 8 4 7 15 15 15 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77270.1 - 7.3e-11 41.3 11.4 12 6.9 0.1 14.6 17 1 1 18 18 16 1 Ankyrin repeat AAA_30 PF13604.6 EFA77270.1 - 4e-05 23.4 0.2 8.4e-05 22.4 0.2 1.4 1 0 0 1 1 1 1 AAA domain Ank PF00023.30 EFA77270.1 - 0.00051 20.4 4.2 9.4 6.9 0.0 7.5 10 0 0 10 10 8 1 Ankyrin repeat UTP25 PF06862.12 EFA77270.1 - 0.0025 16.7 0.1 0.95 8.2 0.0 2.7 3 0 0 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 EFA77270.1 - 0.0041 17.4 0.1 0.011 16.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain tRNA-synt_1b PF00579.25 EFA77270.1 - 0.022 14.1 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Ank_2 PF12796.7 EFA77271.1 - 4.4e-07 30.4 5.6 1.5e-05 25.5 0.2 5.0 3 2 2 5 5 5 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77271.1 - 2.8e-06 27.7 1.6 0.8 10.4 0.0 5.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77271.1 - 0.016 15.7 1.9 33 5.5 0.0 6.1 7 0 0 7 7 7 0 Ankyrin repeat ArgoMid PF16487.5 EFA77271.1 - 1.3 9.3 6.2 2.2 8.6 0.0 3.5 2 1 1 3 3 3 0 Mid domain of argonaute DUF1525 PF07511.11 EFA77271.1 - 7.2 6.8 7.9 23 5.2 7.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Presenilin PF01080.17 EFA77275.1 - 0.00017 20.5 10.2 0.00024 20.0 10.2 1.2 1 0 0 1 1 1 1 Presenilin Atrophin-1 PF03154.15 EFA77275.1 - 0.04 12.2 1.8 0.047 12.0 1.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF4746 PF15928.5 EFA77275.1 - 0.041 13.3 9.2 0.057 12.8 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Trypan_PARP PF05887.11 EFA77275.1 - 0.097 12.7 4.4 0.14 12.2 4.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4820 PF16091.5 EFA77275.1 - 0.21 10.9 8.3 0.31 10.4 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TERB2 PF15101.6 EFA77275.1 - 0.22 11.5 9.2 0.37 10.8 9.2 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SprA-related PF12118.8 EFA77275.1 - 0.65 9.1 16.4 0.84 8.7 16.4 1.2 1 0 0 1 1 1 0 SprA-related family EIIBC-GUT_N PF03612.14 EFA77275.1 - 0.71 9.6 6.8 1.2 8.9 6.8 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Connexin PF00029.19 EFA77275.1 - 0.86 9.3 7.0 1.5 8.6 7.0 1.5 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 EFA77275.1 - 0.97 9.6 7.8 1.5 8.9 7.5 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal eIF_4EBP PF05456.11 EFA77275.1 - 1.3 9.0 6.2 2.9 7.8 6.2 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Neur_chan_memb PF02932.16 EFA77275.1 - 1.5 8.9 4.8 1.7 8.6 4.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ureide_permease PF07168.11 EFA77275.1 - 1.7 7.3 5.6 2.6 6.7 5.6 1.3 1 0 0 1 1 1 0 Ureide permease AIF_C PF14721.6 EFA77275.1 - 2 8.7 6.6 4.5 7.6 6.6 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CobT PF06213.12 EFA77275.1 - 2.4 7.5 19.0 3.6 6.9 19.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 EFA77275.1 - 2.5 7.2 4.7 2.9 7.0 4.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4175 PF13779.6 EFA77275.1 - 2.6 5.8 15.9 3 5.6 15.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CSG2 PF16965.5 EFA77275.1 - 3.7 6.4 7.4 5.5 5.8 7.4 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator RP-C_C PF11800.8 EFA77275.1 - 4.2 7.4 11.1 6.4 6.8 11.1 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF3464 PF11947.8 EFA77275.1 - 4.6 7.0 8.1 7.9 6.2 8.1 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TFB6 PF17110.5 EFA77275.1 - 5.7 6.7 10.5 10 5.8 10.5 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PBP_sp32 PF07222.12 EFA77275.1 - 8.3 5.8 17.7 14 5.1 15.1 2.1 2 0 0 2 2 2 0 Proacrosin binding protein sp32 LRR_8 PF13855.6 EFA77278.1 - 0.04 13.7 0.4 0.065 13.0 0.4 1.4 1 1 0 1 1 1 0 Leucine rich repeat LRR_4 PF12799.7 EFA77278.1 - 0.095 13.2 0.8 0.22 12.0 0.8 1.8 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) CBP_BcsG PF11658.8 EFA77278.1 - 0.49 8.7 3.5 0.51 8.7 3.5 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DcpS_C PF11969.8 EFA77280.1 - 1.8e-25 89.6 0.1 2.5e-25 89.2 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EFA77280.1 - 1.1e-13 51.7 0.1 1.7e-13 51.1 0.1 1.3 1 0 0 1 1 1 1 HIT domain MCM PF00493.23 EFA77281.1 - 1.5e-100 334.9 0.0 2.4e-100 334.3 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFA77281.1 - 4.2e-36 123.6 0.1 7.9e-36 122.7 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFA77281.1 - 4.7e-29 100.6 0.6 4.7e-29 100.6 0.6 2.4 3 0 0 3 3 2 1 MCM AAA-lid domain MCM_N PF14551.6 EFA77281.1 - 9.8e-14 51.8 1.3 3.1e-13 50.2 0.6 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFA77281.1 - 9.5e-09 34.9 0.0 2.4e-07 30.4 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA77281.1 - 1.9e-06 27.9 0.0 5.5e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFA77281.1 - 6.2e-06 26.1 0.0 0.0015 18.4 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MCM2_N PF12619.8 EFA77281.1 - 0.0002 21.6 46.4 0.0013 19.0 42.4 3.0 2 1 0 2 2 2 1 Mini-chromosome maintenance protein 2 Sigma54_activat PF00158.26 EFA77281.1 - 0.013 15.2 0.0 0.13 11.9 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_lid_2 PF17863.1 EFA77281.1 - 0.024 14.5 0.0 0.07 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA lid domain AAA_30 PF13604.6 EFA77281.1 - 0.066 12.9 0.4 0.6 9.8 0.1 2.1 2 0 0 2 2 2 0 AAA domain Y_phosphatase2 PF03162.13 EFA77283.1 - 2.5e-06 27.2 0.0 3.8e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EFA77283.1 - 7.3e-06 25.8 0.0 9.8e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 EFA77283.1 - 1.6e-05 24.7 0.0 2.1e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EFA77283.1 - 0.00014 21.9 0.0 0.00021 21.3 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFA77283.1 - 0.0042 16.7 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFA77283.1 - 0.0087 16.2 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate IL22 PF14565.6 EFA77283.1 - 0.064 13.5 0.0 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor DUF4286 PF14114.6 EFA77283.1 - 0.07 13.6 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) MtrB PF05440.12 EFA77283.1 - 0.12 12.7 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B SnoaL_2 PF12680.7 EFA77285.1 - 4.3e-05 24.1 0.2 6e-05 23.6 0.2 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EFA77285.1 - 0.011 15.5 0.2 0.017 14.9 0.2 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase DUF4805 PF16063.5 EFA77285.1 - 0.032 13.6 2.3 0.046 13.1 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) HopJ PF08888.11 EFA77285.1 - 0.069 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 HopJ type III effector protein TFIIA PF03153.13 EFA77285.1 - 0.083 12.9 6.1 0.085 12.8 6.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 EFA77285.1 - 0.33 11.0 11.9 0.53 10.3 11.9 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF3439 PF11921.8 EFA77285.1 - 0.91 9.5 6.9 1.4 8.9 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ndc1_Nup PF09531.10 EFA77285.1 - 0.97 8.0 6.0 1 7.9 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 EFA77285.1 - 1.9 7.6 8.9 2.2 7.4 8.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2464 PF10240.9 EFA77285.1 - 2.9 7.4 6.5 4.2 6.9 6.5 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 Pex14_N PF04695.13 EFA77285.1 - 5.3 7.7 16.3 9 6.9 16.3 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FNIP PF05725.12 EFA77286.1 - 2.3e-45 152.5 44.5 3.8e-14 52.6 0.0 9.8 6 3 3 9 9 9 8 FNIP Repeat MMR_HSR1_Xtn PF16897.5 EFA77288.1 - 6.5e-41 138.7 0.1 1.1e-40 137.9 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EFA77288.1 - 1.2e-21 76.5 0.0 2.1e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EFA77288.1 - 3.3e-20 72.3 0.0 8e-20 71.0 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA77288.1 - 5.5e-09 35.7 0.0 1e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFA77288.1 - 0.0037 17.3 0.3 0.59 10.2 0.0 2.5 1 1 1 2 2 2 1 Dynamin family MeaB PF03308.16 EFA77288.1 - 0.037 13.0 0.2 0.12 11.3 0.1 1.9 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EFA77288.1 - 0.042 13.2 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 AIG1 family RsgA_GTPase PF03193.16 EFA77288.1 - 0.042 13.7 0.3 0.17 11.8 0.2 2.1 2 1 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 EFA77288.1 - 0.083 13.1 0.1 0.23 11.7 0.1 1.7 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EFA77288.1 - 0.085 13.1 0.1 0.46 10.7 0.0 2.2 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA77288.1 - 0.088 12.2 0.1 0.23 10.9 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EFA77288.1 - 0.16 12.4 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain KH_5 PF13184.6 EFA77289.1 - 0.084 13.0 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 NusA-like KH domain Ank_2 PF12796.7 EFA77290.1 - 4e-07 30.5 1.2 0.078 13.6 0.1 3.3 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77290.1 - 1.1e-06 29.1 0.4 0.032 14.8 0.0 4.1 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77290.1 - 6.2e-06 26.2 0.8 31 5.6 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFA77290.1 - 8.6e-05 22.7 2.1 0.28 11.6 0.2 4.5 2 1 3 5 5 5 1 Ankyrin repeats (many copies) MCM PF00493.23 EFA77292.1 - 7.5e-90 299.9 0.1 3.3e-89 297.8 0.0 2.1 2 0 0 2 2 2 1 MCM P-loop domain Pkinase_Tyr PF07714.17 EFA77292.1 - 2.1e-30 105.9 0.0 4.1e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase MCM_lid PF17855.1 EFA77292.1 - 1.8e-27 95.6 1.2 5.1e-27 94.1 1.2 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain Pkinase PF00069.25 EFA77292.1 - 7.6e-27 94.3 0.0 1.5e-26 93.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 EFA77292.1 - 5.2e-25 88.4 14.4 1.9e-15 57.2 4.1 4.6 4 0 0 4 4 4 3 C-terminal of Roc, COR, domain MCM_OB PF17207.3 EFA77292.1 - 2.5e-24 85.5 1.2 2.5e-24 85.5 1.2 2.1 2 0 0 2 2 1 1 MCM OB domain Roc PF08477.13 EFA77292.1 - 4.5e-23 81.8 10.7 3.5e-17 62.7 0.1 4.3 4 0 0 4 4 4 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA77292.1 - 2.6e-16 59.7 3.3 9.3e-12 44.8 0.1 3.5 3 0 0 3 3 3 2 Ras family PH PF00169.29 EFA77292.1 - 2.3e-09 37.7 0.4 2.3e-09 37.7 0.4 2.5 2 0 0 2 2 1 1 PH domain Mg_chelatase PF01078.21 EFA77292.1 - 2.5e-09 36.8 0.3 6.4e-06 25.7 0.0 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA77292.1 - 1.7e-06 28.1 0.1 9e-06 25.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA77292.1 - 8.7e-06 26.2 0.1 0.0098 16.3 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EFA77292.1 - 0.00026 21.0 0.4 0.067 13.3 0.2 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_3 PF07726.11 EFA77292.1 - 0.0004 20.2 0.0 0.0028 17.5 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFA77292.1 - 0.00093 19.0 0.2 0.32 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EFA77292.1 - 0.00097 18.6 0.1 1.1 8.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein AAA_22 PF13401.6 EFA77292.1 - 0.0018 18.6 0.0 2 8.7 0.0 3.1 2 1 0 2 2 2 1 AAA domain PH_8 PF15409.6 EFA77292.1 - 0.0018 18.5 0.0 0.0077 16.5 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFA77292.1 - 0.025 15.0 0.0 0.025 15.0 0.0 3.7 3 0 0 3 3 2 0 Pleckstrin homology domain AAA PF00004.29 EFA77292.1 - 0.031 14.7 0.9 2.1 8.8 0.0 3.4 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Arf PF00025.21 EFA77292.1 - 0.032 13.7 1.1 0.72 9.3 0.1 2.6 2 0 0 2 2 2 0 ADP-ribosylation factor family FtsK_SpoIIIE PF01580.18 EFA77292.1 - 0.14 11.5 0.5 0.67 9.3 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family DC_STAMP PF07782.13 EFA77292.1 - 0.14 11.9 1.4 16 5.2 0.0 2.8 3 0 0 3 3 2 0 DC-STAMP-like protein Sigma54_activat PF00158.26 EFA77292.1 - 0.15 11.7 0.2 1 9.0 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EFA77292.1 - 0.2 11.5 3.8 2 8.3 0.1 3.2 2 1 0 3 3 3 0 NTPase SdrD_B PF17210.3 EFA77293.1 - 2e-11 44.1 0.0 5.1e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA77293.1 - 0.0019 18.4 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain TTR-52 PF01060.23 EFA77293.1 - 0.035 14.8 0.0 0.091 13.5 0.0 1.7 1 0 0 1 1 1 0 Transthyretin-like family Ank_4 PF13637.6 EFA77294.1 - 2.9e-24 85.1 1.2 8.5e-13 48.5 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA77294.1 - 4.1e-16 58.6 2.5 1.7e-09 37.7 0.2 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EFA77294.1 - 1.3e-15 57.8 0.4 1.8e-15 57.3 0.4 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA77294.1 - 2.8e-13 49.8 0.6 1.8e-06 28.1 0.1 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77294.1 - 1.8e-10 40.1 0.3 3.3e-05 23.9 0.0 2.6 3 0 0 3 3 3 2 Ankyrin repeat Phosphoprotein PF00922.17 EFA77294.1 - 0.27 10.8 3.9 0.43 10.2 3.9 1.3 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein NOA36 PF06524.12 EFA77294.1 - 4.1 6.6 8.9 4.6 6.5 8.9 1.2 1 1 0 1 1 1 0 NOA36 protein GDP_Man_Dehyd PF16363.5 EFA77295.1 - 1.8e-37 129.5 0.4 1.1e-31 110.5 0.4 2.2 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA77295.1 - 1.2e-29 103.5 0.1 2e-29 102.8 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFA77295.1 - 1.4e-16 60.5 0.0 1.9e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFA77295.1 - 7e-13 48.2 0.3 1e-12 47.7 0.3 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFA77295.1 - 8.1e-08 31.7 0.5 2.1e-05 23.8 0.1 2.2 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EFA77295.1 - 2.8e-07 29.9 0.0 1.1e-06 27.9 0.0 1.8 1 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFA77295.1 - 0.0068 16.3 0.0 0.064 13.1 0.0 2.1 1 1 1 2 2 2 1 NAD(P)H-binding NAD_binding_8 PF13450.6 EFA77295.1 - 0.057 13.7 0.0 0.16 12.2 0.0 1.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Baculo_LEF-11 PF06385.12 EFA77295.1 - 0.065 13.7 0.0 0.065 13.7 0.0 2.0 2 0 0 2 2 2 0 Baculovirus LEF-11 protein KR PF08659.10 EFA77295.1 - 0.079 12.9 0.1 0.43 10.5 0.1 2.0 1 1 0 1 1 1 0 KR domain LRR_8 PF13855.6 EFA77296.1 - 2e-06 27.4 0.1 2e-06 27.4 0.1 2.2 2 0 0 2 2 2 1 Leucine rich repeat S-AdoMet_synt_M PF02772.16 EFA77296.1 - 0.13 12.5 5.2 0.13 12.6 3.0 2.1 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, central domain tRNA-synt_2b PF00587.25 EFA77297.1 - 3.3e-36 124.9 0.0 8.4e-36 123.6 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFA77297.1 - 7.5e-23 80.5 0.5 1.7e-22 79.3 0.5 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EFA77297.1 - 1.4e-11 44.3 0.0 2.9e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EFA77297.1 - 7.1e-11 42.0 0.4 1.1e-09 38.2 0.0 2.7 3 0 0 3 3 3 1 TGS domain DUF3439 PF11921.8 EFA77298.1 - 0.012 15.6 6.2 0.012 15.6 6.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) DUF4266 PF14086.6 EFA77298.1 - 3.1 8.8 7.5 13 6.8 3.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) Cnd1 PF12717.7 EFA77299.1 - 4.4e-27 95.1 22.5 5e-24 85.2 0.1 7.6 7 2 0 8 8 8 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFA77299.1 - 3.4e-10 39.3 5.7 0.24 11.7 0.3 6.8 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 EFA77299.1 - 1.2e-06 28.8 0.8 0.26 11.7 0.0 4.5 3 1 1 4 4 4 2 HEAT repeats HutD PF05962.11 EFA77299.1 - 0.00019 21.5 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 HutD HEAT_EZ PF13513.6 EFA77299.1 - 0.00029 21.3 4.0 1.6 9.3 0.0 5.2 6 0 0 6 6 6 1 HEAT-like repeat Cohesin_HEAT PF12765.7 EFA77299.1 - 0.0095 16.2 2.6 1 9.7 0.1 3.8 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.8 EFA77299.1 - 0.018 14.6 7.7 1.7 8.2 0.1 4.7 4 1 0 4 4 4 0 CLASP N terminal SapB_1 PF05184.15 EFA77299.1 - 0.1 12.7 4.3 2.7 8.1 0.0 3.7 3 0 0 3 3 3 0 Saposin-like type B, region 1 zf-C3HC4_3 PF13920.6 EFA77300.1 - 5.6e-11 42.1 13.8 9.7e-11 41.4 13.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA77300.1 - 0.0001 22.1 13.6 0.0002 21.2 13.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF4407 PF14362.6 EFA77300.1 - 0.14 11.4 16.1 0.37 10.1 16.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EFA77300.1 - 0.15 12.1 24.3 0.16 12.1 21.9 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein zf-RING_5 PF14634.6 EFA77300.1 - 0.24 11.4 14.6 0.46 10.5 14.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain MscS_porin PF12795.7 EFA77300.1 - 0.4 10.2 26.9 0.62 9.6 26.2 1.7 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain GAS PF13851.6 EFA77300.1 - 0.57 9.5 35.6 0.05 13.0 30.3 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3439 PF11921.8 EFA77300.1 - 0.65 10.0 10.3 0.25 11.3 2.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) zf-RING_2 PF13639.6 EFA77300.1 - 1.1 9.6 15.3 2.3 8.6 15.3 1.6 1 0 0 1 1 1 0 Ring finger domain Suppressor_APC PF11414.8 EFA77300.1 - 1.6 8.8 6.7 0.67 10.1 1.7 2.7 1 1 1 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein FNIP PF05725.12 EFA77301.1 - 1.4e-16 60.4 22.6 0.00015 21.8 0.2 7.4 3 2 5 9 9 9 9 FNIP Repeat F-box_5 PF18511.1 EFA77301.1 - 1.1e-05 24.9 0.1 2.9e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77301.1 - 0.0082 16.0 0.4 0.026 14.4 0.4 1.8 1 0 0 1 1 1 1 F-box-like Y_Y_Y PF07495.13 EFA77301.1 - 0.054 13.4 0.0 0.19 11.7 0.0 1.9 1 0 0 1 1 1 0 Y_Y_Y domain FNIP PF05725.12 EFA77302.1 - 4.6e-16 58.7 10.5 5.6e-06 26.4 0.6 5.6 4 2 2 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA77302.1 - 0.0007 19.1 0.3 0.0015 18.1 0.3 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77302.1 - 0.043 13.7 0.5 0.1 12.5 0.5 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFA77302.1 - 0.047 13.6 0.4 0.13 12.2 0.4 1.7 1 0 0 1 1 1 0 F-box domain TFIIB PF00382.19 EFA77303.1 - 1.8e-44 149.6 0.4 3.2e-22 78.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EFA77303.1 - 1.4e-12 46.9 1.3 2.8e-12 45.9 1.3 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 EFA77303.1 - 0.00042 20.4 0.2 0.28 11.3 0.1 2.3 1 1 1 2 2 2 2 Cyclin, C-terminal domain RB_B PF01857.20 EFA77303.1 - 0.00044 20.3 0.1 0.0021 18.1 0.0 2.0 2 1 0 2 2 2 1 Retinoblastoma-associated protein B domain Cyclin_N PF00134.23 EFA77303.1 - 0.019 14.7 0.0 0.041 13.6 0.0 1.5 2 0 0 2 2 2 0 Cyclin, N-terminal domain SMC_N PF02463.19 EFA77304.1 - 2e-24 86.3 6.0 7.7e-24 84.3 6.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFA77304.1 - 1.2e-11 45.5 75.8 3e-11 44.2 31.8 5.0 2 2 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EFA77304.1 - 1.2e-08 35.1 0.7 8.3e-05 22.5 0.1 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA77304.1 - 0.00024 20.8 0.0 0.00062 19.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EFA77304.1 - 0.00027 20.8 25.6 0.00027 20.8 25.6 4.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 EFA77304.1 - 0.00032 20.4 9.2 0.03 13.9 0.0 4.4 3 1 0 3 3 3 2 AAA domain FliJ PF02050.16 EFA77304.1 - 0.0052 17.0 0.3 0.0052 17.0 0.3 6.7 3 2 4 7 7 7 1 Flagellar FliJ protein DUF4108 PF13390.6 EFA77304.1 - 0.0075 16.2 0.1 0.0075 16.2 0.1 4.2 2 1 4 6 6 6 1 Protein of unknown function (DUF4108) AAA_25 PF13481.6 EFA77304.1 - 0.036 13.6 0.0 0.12 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EFA77304.1 - 8.3 4.9 75.2 6.3 5.3 0.0 5.4 3 2 1 4 4 4 0 AAA domain SLAC1 PF03595.17 EFA77305.1 - 0.015 14.6 1.2 0.016 14.5 1.2 1.0 1 0 0 1 1 1 0 Voltage-dependent anion channel Chromate_transp PF02417.15 EFA77305.1 - 0.12 12.5 1.7 1.3 9.1 1.8 1.9 1 1 1 2 2 2 0 Chromate transporter ASFV_J13L PF05568.11 EFA77305.1 - 0.35 10.6 2.1 0.64 9.7 0.0 1.9 2 0 0 2 2 2 0 African swine fever virus J13L protein Carb_kinase PF01256.17 EFA77306.1 - 2e-49 168.3 0.0 2.9e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EFA77306.1 - 0.0014 18.1 0.3 0.003 17.0 0.3 1.6 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family OMS28_porin PF03532.13 EFA77306.1 - 0.069 12.4 1.7 0.07 12.4 0.1 1.7 2 0 0 2 2 2 0 OMS28 porin CdhD PF03599.16 EFA77306.1 - 0.12 11.1 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit TT_ORF1 PF02956.14 EFA77306.1 - 2.1 6.9 5.7 2.8 6.5 5.7 1.1 1 0 0 1 1 1 0 TT viral orf 1 Vma12 PF11712.8 EFA77307.1 - 7.3e-08 32.6 0.1 3.3e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase TIG PF01833.24 EFA77307.1 - 1.5e-06 28.2 12.1 1.7e-05 24.8 0.4 4.2 3 0 0 3 3 3 2 IPT/TIG domain TMEM154 PF15102.6 EFA77307.1 - 0.009 15.9 0.2 0.009 15.9 0.2 2.6 3 0 0 3 3 3 1 TMEM154 protein family Chordopox_A13L PF05961.11 EFA77307.1 - 0.017 15.4 0.3 0.017 15.4 0.3 2.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Insulin_TMD PF17870.1 EFA77307.1 - 0.05 13.7 6.8 0.033 14.3 4.1 2.2 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment TMEM107 PF14995.6 EFA77307.1 - 0.22 12.0 1.1 0.9 10.0 0.0 2.6 2 0 0 2 2 2 0 Transmembrane protein EphA2_TM PF14575.6 EFA77307.1 - 0.36 11.7 2.0 1.1 10.2 0.1 2.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain zf-LITAF-like PF10601.9 EFA77308.1 - 0.0087 16.3 0.2 0.012 15.9 0.2 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Pkinase PF00069.25 EFA77309.1 - 1.6e-80 270.3 0.0 1.8e-80 270.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77309.1 - 1.9e-34 119.1 0.0 3e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFA77309.1 - 0.00035 19.7 0.0 0.0054 15.7 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFA77309.1 - 0.0011 18.3 0.0 0.013 14.8 0.0 2.3 2 1 0 3 3 3 1 Kinase-like APH PF01636.23 EFA77309.1 - 0.016 15.1 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFA77309.1 - 0.035 13.5 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family tRNA_lig_kinase PF08303.11 EFA77310.1 - 0.0043 17.1 0.3 0.0068 16.5 0.3 1.3 1 0 0 1 1 1 1 tRNA ligase kinase domain Herpes_UL69 PF05459.12 EFA77310.1 - 0.055 12.8 0.1 0.078 12.3 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family BcrAD_BadFG PF01869.20 EFA77310.1 - 0.12 11.8 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Myb_DNA-binding PF00249.31 EFA77311.1 - 3.6e-48 161.5 16.0 9.1e-16 57.8 0.5 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA77311.1 - 3.2e-36 123.4 12.3 3.6e-17 62.3 1.1 4.9 2 1 2 4 4 4 3 Myb-like DNA-binding domain Rap1_C PF11626.8 EFA77311.1 - 2e-05 24.6 4.3 0.59 10.3 0.4 3.8 1 1 2 3 3 3 3 TRF2-interacting telomeric protein/Rap1 - C terminal domain LRR_6 PF13516.6 EFA77312.1 - 1.9e-12 46.2 36.3 0.12 12.4 0.2 10.7 12 0 0 12 12 12 7 Leucine Rich repeat LRR_4 PF12799.7 EFA77312.1 - 0.00058 20.2 39.7 0.76 10.3 0.4 7.6 4 2 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA77312.1 - 0.0014 18.9 23.6 27 5.8 0.0 10.0 10 0 0 10 10 10 2 Leucine Rich Repeat Myosin_TH1 PF06017.13 EFA77312.1 - 0.0032 17.2 0.1 0.006 16.3 0.1 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Carm_PH PF17888.1 EFA77312.1 - 0.13 12.6 0.2 0.3 11.5 0.2 1.6 1 0 0 1 1 1 0 Carmil pleckstrin homology domain P21-Arc PF04062.14 EFA77313.1 - 7.2e-60 202.0 0.0 1.3e-59 201.1 0.0 1.4 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit NAPRTase_N PF17767.1 EFA77313.1 - 1.2e-37 129.0 0.1 3.2e-37 127.7 0.1 1.7 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 EFA77313.1 - 3.2e-33 114.5 0.0 6.4e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 EFA77313.1 - 1.3e-06 28.2 0.0 0.0062 16.2 0.0 2.3 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family QRPTase_N PF02749.16 EFA77313.1 - 0.16 12.1 0.0 0.64 10.1 0.0 2.0 1 1 0 1 1 1 0 Quinolinate phosphoribosyl transferase, N-terminal domain Sec20 PF03908.13 EFA77314.1 - 4.4 7.3 8.2 3.4 7.6 0.1 3.5 3 0 0 3 3 3 0 Sec20 Sec7 PF01369.20 EFA77315.1 - 2.2e-61 206.7 0.1 5.7e-61 205.4 0.1 1.8 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EFA77315.1 - 3.9e-09 37.0 9.7 2e-07 31.5 0.2 3.6 4 0 0 4 4 4 2 PH domain zf-RING_2 PF13639.6 EFA77316.1 - 1.7e-12 47.4 3.4 3.4e-12 46.5 3.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFA77316.1 - 5.5e-10 38.8 2.6 1.3e-09 37.7 2.6 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EFA77316.1 - 8.4e-08 32.4 5.5 3e-07 30.6 5.5 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFA77316.1 - 1.1e-07 31.5 2.6 2.5e-07 30.4 2.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA77316.1 - 3.4e-05 23.6 3.6 3.4e-05 23.6 3.6 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA77316.1 - 4.6e-05 23.3 3.1 0.00011 22.2 3.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA77316.1 - 7.9e-05 22.5 4.1 0.00019 21.3 3.8 1.8 1 1 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFA77316.1 - 0.00028 20.4 4.6 0.00052 19.6 4.6 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EFA77316.1 - 0.00039 20.4 1.1 0.00096 19.2 1.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EFA77316.1 - 0.0074 16.4 5.9 0.016 15.4 5.9 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.7 EFA77316.1 - 0.012 15.7 2.5 0.029 14.5 2.5 1.7 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EFA77316.1 - 0.016 15.0 2.5 0.016 15.0 2.5 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EFA77316.1 - 0.091 12.6 4.6 0.13 12.1 3.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 CBP_BcsN PF17038.5 EFA77316.1 - 0.14 11.5 1.5 0.81 9.0 0.7 2.3 2 1 0 2 2 2 0 Cellulose biosynthesis protein BcsN zf-RING-like PF08746.11 EFA77316.1 - 4.2 7.8 7.3 0.2 12.0 0.6 2.1 2 0 0 2 2 2 0 RING-like domain PBD PF00786.28 EFA77317.1 - 9.5e-18 64.3 0.1 2e-17 63.3 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain WH1 PF00568.23 EFA77317.1 - 1e-17 64.0 0.1 1.6e-17 63.4 0.1 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EFA77317.1 - 1.1e-07 31.4 0.9 2.5e-07 30.3 0.9 1.6 1 0 0 1 1 1 1 WH2 motif DCP1 PF06058.13 EFA77317.1 - 0.00039 20.3 0.0 0.00058 19.8 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family Mob1_phocein PF03637.17 EFA77318.1 - 2.4e-44 151.3 0.2 3.1e-44 151.0 0.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family DUF1744 PF08490.12 EFA77319.1 - 3.3e-117 391.4 0.1 3.3e-117 391.4 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EFA77319.1 - 3.1e-69 233.7 1.7 3.1e-69 233.7 1.7 2.0 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EFA77319.1 - 1.2e-13 50.7 5.4 2.7e-08 33.0 1.2 4.6 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EFA77319.1 - 3.8e-05 23.5 0.4 0.00052 19.8 0.4 2.6 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EFA77319.1 - 9e-05 22.5 0.1 0.0011 18.9 0.0 3.1 2 1 0 2 2 2 1 RNase_H superfamily Cytochrom_c3_2 PF14537.6 EFA77319.1 - 0.99 9.9 5.7 4.6 7.8 5.7 2.2 1 0 0 1 1 1 0 Cytochrome c3 ATG27 PF09451.10 EFA77320.1 - 3.3e-21 76.3 0.8 9.3e-21 74.9 0.8 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFA77320.1 - 1.5e-09 37.3 1.2 2.9e-09 36.4 1.2 1.7 1 1 0 1 1 1 1 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 EFA77320.1 - 0.00067 19.4 0.2 0.0012 18.6 0.2 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein RNB PF00773.19 EFA77322.1 - 1.6e-84 284.0 0.0 1.6e-84 284.0 0.0 2.7 3 0 0 3 3 3 1 RNB domain OB_Dis3 PF17849.1 EFA77322.1 - 3.3e-16 59.1 0.0 9.2e-16 57.6 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EFA77322.1 - 2.3e-07 30.8 0.3 6.6e-06 26.2 0.0 3.2 3 0 0 3 3 3 1 Cold shock domain Rrp44_S1 PF17215.3 EFA77322.1 - 5.4e-07 29.5 0.1 2.3e-06 27.4 0.1 2.1 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 EFA77322.1 - 1.6e-06 27.9 0.1 1.6e-06 27.9 0.1 2.9 3 0 0 3 3 3 1 Rrp44-like cold shock domain SUIM_assoc PF16619.5 EFA77322.1 - 0.025 14.6 27.4 0.2 11.7 5.1 3.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Dis3l2_C_term PF17877.1 EFA77322.1 - 0.13 12.6 0.0 0.13 12.6 0.0 3.5 3 0 0 3 3 3 0 DIS3-like exonuclease 2 C terminal Androgen_recep PF02166.16 EFA77322.1 - 4.2 6.1 14.0 9.7 4.9 7.6 2.4 2 0 0 2 2 2 0 Androgen receptor FKBP_C PF00254.28 EFA77323.1 - 1.2e-10 41.6 0.0 3.1e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CortBP2 PF09727.9 EFA77323.1 - 0.015 15.2 0.9 0.032 14.1 0.9 1.5 1 0 0 1 1 1 0 Cortactin-binding protein-2 TPR_2 PF07719.17 EFA77323.1 - 2.2 8.6 6.3 8.7 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Pentapeptide_3 PF13576.6 EFA77324.1 - 2 8.7 11.5 35 4.7 0.2 5.5 4 0 0 4 4 4 0 Pentapeptide repeats (9 copies) GFA PF04828.14 EFA77325.1 - 8.1e-09 35.7 0.8 8.1e-09 35.7 0.8 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Phosphodiest PF01663.22 EFA77326.1 - 1.2e-06 28.3 1.2 1.1e-05 25.2 0.3 2.4 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase AJAP1_PANP_C PF15298.6 EFA77326.1 - 0.47 10.6 15.6 0.04 14.1 7.6 2.6 2 0 0 2 2 2 0 AJAP1/PANP C-terminus EF-hand_7 PF13499.6 EFA77327.1 - 1.4e-17 63.8 6.1 9.9e-14 51.6 0.5 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFA77327.1 - 3.9e-16 57.3 3.5 1.7e-07 30.3 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFA77327.1 - 4.9e-15 55.1 3.0 9.3e-10 38.2 0.3 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA77327.1 - 1.2e-13 49.8 6.2 2.3e-07 30.2 0.2 3.6 3 1 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EFA77327.1 - 2.8e-11 42.3 2.6 5.1e-05 22.6 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EFA77327.1 - 1.4e-06 28.6 0.1 3.9e-06 27.1 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EFA77327.1 - 0.0025 18.1 0.1 0.0039 17.5 0.1 1.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EFA77327.1 - 0.018 15.2 0.3 0.037 14.2 0.3 1.5 1 0 0 1 1 1 0 Dockerin type I domain EF-hand_14 PF17959.1 EFA77327.1 - 0.038 14.3 0.9 5.6 7.4 0.1 2.6 2 2 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 EFA77327.1 - 0.067 13.2 2.9 1.1 9.2 0.5 2.8 1 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SQHop_cyclase_C PF13243.6 EFA77327.1 - 0.079 12.1 0.1 0.089 11.9 0.1 1.1 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain DUF2767 PF10965.8 EFA77327.1 - 0.081 12.9 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2767) EF-hand_10 PF14788.6 EFA77327.1 - 0.16 11.8 2.1 3.1 7.7 0.1 3.0 3 1 0 3 3 3 0 EF hand THUMP PF02926.17 EFA77328.1 - 3.6e-07 30.4 0.2 7.5e-07 29.3 0.2 1.6 1 0 0 1 1 1 1 THUMP domain PhetRS_B1 PF18262.1 EFA77328.1 - 0.11 12.7 1.4 0.58 10.4 0.9 2.4 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain EOS1 PF12326.8 EFA77329.1 - 1.1 9.2 5.9 0.19 11.7 1.1 2.2 2 2 0 2 2 2 0 N-glycosylation protein Isochorismatase PF00857.20 EFA77330.1 - 2.1e-35 122.5 0.0 2.4e-35 122.3 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family Ubie_methyltran PF01209.18 EFA77331.1 - 6.5e-20 71.5 0.0 7.6e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Ubie_methyltran PF01209.18 EFA77332.1 - 2e-65 220.4 0.0 2.4e-65 220.1 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EFA77332.1 - 2.3e-12 47.4 0.0 6.7e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA77332.1 - 9.2e-12 45.5 0.0 2.2e-11 44.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA77332.1 - 1.3e-06 28.3 0.0 2.6e-06 27.3 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA77332.1 - 0.00016 21.6 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77332.1 - 0.00099 19.8 0.0 0.0017 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFA77332.1 - 0.0053 16.6 0.0 0.22 11.4 0.0 2.1 2 0 0 2 2 2 1 Hypothetical methyltransferase MFS_1 PF07690.16 EFA77333.1 - 2.6e-34 118.7 36.7 6.6e-20 71.3 14.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3810 PF12725.7 EFA77333.1 - 0.068 12.5 1.1 0.22 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) HH_signal PF01085.18 EFA77333.1 - 0.65 9.6 2.1 19 4.9 0.1 2.4 2 0 0 2 2 2 0 Hedgehog amino-terminal signalling domain SpoVAB PF13782.6 EFA77333.1 - 4.8 7.5 10.3 0.34 11.2 2.7 2.8 2 0 0 2 2 2 0 Stage V sporulation protein AB Na_H_Exchanger PF00999.21 EFA77334.1 - 3.3e-59 200.6 42.9 4.1e-59 200.3 42.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Asp-Al_Ex PF06826.12 EFA77334.1 - 0.00037 20.3 6.2 0.00037 20.3 6.2 3.0 2 2 2 4 4 4 1 Predicted Permease Membrane Region MRP-L46 PF11788.8 EFA77335.1 - 0.0013 19.4 5.1 0.0026 18.5 1.7 2.8 2 1 0 2 2 2 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 EFA77335.1 - 0.023 14.7 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 NUDIX domain Tweety PF04906.13 EFA77336.1 - 1.5e-12 46.9 4.6 8.2e-11 41.2 3.3 2.2 2 0 0 2 2 2 2 Tweety TRPM_tetra PF16519.5 EFA77336.1 - 0.1 12.7 0.1 0.26 11.4 0.1 1.6 1 0 0 1 1 1 0 Tetramerisation domain of TRPM DUF2062 PF09835.9 EFA77336.1 - 0.14 12.0 0.0 0.14 12.0 0.0 2.6 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) Ribosomal_L14 PF00238.19 EFA77337.1 - 1.7e-29 102.4 0.1 2.1e-29 102.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e EF-hand_1 PF00036.32 EFA77338.1 - 1.1e-10 40.2 0.0 2.8e-05 23.3 0.0 2.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA77338.1 - 5.7e-10 38.3 0.1 3.1e-05 23.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EFA77338.1 - 1.5e-07 31.8 0.1 2e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFA77338.1 - 1.2e-06 27.7 0.1 0.0061 16.0 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFA77338.1 - 3.9e-05 23.4 0.1 0.076 12.9 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair Alpha-amylase PF00128.24 EFA77339.1 - 8.4e-55 186.7 1.5 2e-54 185.4 1.5 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EFA77339.1 - 0.009 16.3 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) GHL6 PF14871.6 EFA77339.1 - 0.046 13.9 0.0 0.42 10.8 0.0 2.3 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 DUF1971 PF09313.11 EFA77339.1 - 0.16 12.0 0.0 1.3 9.1 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1971) RFXA_RFXANK_bdg PF15289.6 EFA77340.1 - 0.056 13.8 0.0 0.077 13.3 0.0 1.3 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain Sulf_transp PF04143.14 EFA77342.1 - 6e-48 164.0 15.0 8.3e-48 163.5 15.0 1.1 1 0 0 1 1 1 1 Sulphur transport Acetyltransf_10 PF13673.7 EFA77342.1 - 1.2e-13 51.1 0.0 2e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA77342.1 - 1.1e-12 48.2 0.0 1.9e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA77342.1 - 3.1e-11 43.6 0.1 6.5e-11 42.5 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFA77342.1 - 0.0015 18.1 0.6 0.0022 17.5 0.6 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase FR47 PF08445.10 EFA77342.1 - 0.0017 18.3 0.0 0.0035 17.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFA77342.1 - 0.0027 17.9 0.4 0.0045 17.1 0.4 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 EFA77342.1 - 0.0094 15.7 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ SKG6 PF08693.10 EFA77343.1 - 0.0019 17.5 2.6 0.0047 16.3 2.6 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Y_Y_Y PF07495.13 EFA77343.1 - 0.011 15.6 0.7 0.14 12.2 0.1 3.0 2 0 0 2 2 2 0 Y_Y_Y domain Macoilin PF09726.9 EFA77343.1 - 0.55 8.7 16.7 0.75 8.3 16.7 1.1 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 EFA77343.1 - 1.4 6.9 25.8 1.7 6.6 25.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF1180 PF06679.12 EFA77343.1 - 2.7 8.4 6.0 5.2 7.4 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SPX PF03105.19 EFA77343.1 - 6 6.7 15.2 8.6 6.2 15.2 1.1 1 0 0 1 1 1 0 SPX domain Lon_C PF05362.13 EFA77344.1 - 1.5e-67 227.1 0.0 2.5e-67 226.4 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain DUF1751 PF08551.10 EFA77344.1 - 4.3e-22 78.5 7.1 4.3e-22 78.5 7.1 2.3 3 0 0 3 3 2 1 Eukaryotic integral membrane protein (DUF1751) AAA PF00004.29 EFA77344.1 - 4.5e-20 72.4 0.5 1.9e-11 44.5 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EFA77344.1 - 8.3e-05 22.6 2.4 0.00031 20.7 0.4 2.6 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain Rhomboid PF01694.22 EFA77344.1 - 0.00044 20.3 17.2 0.0011 19.0 17.2 1.6 1 0 0 1 1 1 1 Rhomboid family ChlI PF13541.6 EFA77344.1 - 0.00076 19.3 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 EFA77344.1 - 0.00082 18.4 0.0 0.0015 17.5 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_5 PF07728.14 EFA77344.1 - 0.0017 18.4 0.0 0.0078 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Phage_rep_org_N PF09681.10 EFA77344.1 - 0.0087 16.0 0.2 0.038 13.9 0.0 2.2 2 0 0 2 2 2 1 N-terminal phage replisome organiser (Phage_rep_org_N) AAA_16 PF13191.6 EFA77344.1 - 0.021 15.2 0.0 0.071 13.5 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFA77344.1 - 0.024 15.2 0.0 0.068 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFA77344.1 - 0.025 14.3 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain SKI PF01202.22 EFA77344.1 - 0.09 12.9 0.1 0.26 11.4 0.1 1.8 1 0 0 1 1 1 0 Shikimate kinase AAA_7 PF12775.7 EFA77344.1 - 0.099 12.2 0.9 0.35 10.4 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_19 PF13245.6 EFA77344.1 - 0.14 12.5 0.1 0.58 10.5 0.1 2.0 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EFA77344.1 - 0.4 9.8 3.5 0.17 11.1 0.1 2.0 3 0 0 3 3 3 0 TIP49 P-loop domain AAA_22 PF13401.6 EFA77344.1 - 0.54 10.5 2.2 0.83 9.9 0.1 2.4 3 0 0 3 3 2 0 AAA domain ABC_tran PF00005.27 EFA77344.1 - 1.6 9.3 4.6 0.92 10.0 0.1 2.7 3 0 0 3 3 2 0 ABC transporter Roughex PF06020.11 EFA77345.1 - 0.044 12.9 3.9 0.081 12.0 3.9 1.5 1 0 0 1 1 1 0 Drosophila roughex protein SMYLE_N PF18615.1 EFA77345.1 - 0.055 13.0 5.4 0.069 12.7 5.4 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FapA PF03961.13 EFA77345.1 - 0.11 11.0 5.7 0.23 10.0 5.7 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Med3 PF11593.8 EFA77345.1 - 0.22 10.6 18.6 0.44 9.7 18.6 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SprA-related PF12118.8 EFA77345.1 - 2.2 7.3 18.6 3.1 6.8 18.6 1.2 1 0 0 1 1 1 0 SprA-related family FAM199X PF15814.5 EFA77345.1 - 6.3 5.7 12.2 3.9 6.5 10.4 1.5 2 0 0 2 2 2 0 Protein family FAM199X ARD PF03079.14 EFA77345.1 - 7 6.8 10.1 4.6 7.4 5.9 2.5 2 1 0 2 2 2 0 ARD/ARD' family CBM49 PF09478.10 EFA77346.1 - 1.3e-09 38.2 0.2 2.3e-09 37.4 0.2 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Acetyltransf_10 PF13673.7 EFA77347.1 - 1.9e-11 44.0 0.0 2.3e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA77347.1 - 3.1e-09 37.1 0.1 3.9e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA77347.1 - 8.9e-08 32.5 0.1 1.4e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 EFA77347.1 - 8.1e-06 26.5 0.5 2e-05 25.3 0.4 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA77347.1 - 0.021 14.8 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein STAS PF01740.21 EFA77347.1 - 0.094 12.4 0.1 0.37 10.5 0.0 1.8 2 0 0 2 2 2 0 STAS domain SF3A3 PF16837.5 EFA77347.1 - 0.14 12.7 2.9 0.32 11.5 0.4 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 FNIP PF05725.12 EFA77348.1 - 9.2e-54 179.4 45.7 1.5e-12 47.5 3.0 10.2 8 1 1 10 10 10 7 FNIP Repeat UBX PF00789.20 EFA77348.1 - 8.5e-05 22.7 0.0 0.00027 21.1 0.0 1.9 1 0 0 1 1 1 1 UBX domain zf-AN1 PF01428.16 EFA77348.1 - 0.00073 19.7 7.0 0.0014 18.7 7.0 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger F-box PF00646.33 EFA77348.1 - 0.011 15.7 2.5 0.04 13.8 2.5 2.0 1 0 0 1 1 1 0 F-box domain LBP_C PF17386.2 EFA77348.1 - 0.17 11.8 1.1 0.59 10.1 0.5 2.2 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase C-terminal domain YqeY PF09424.10 EFA77348.1 - 0.36 10.9 5.0 0.87 9.7 5.0 1.5 1 0 0 1 1 1 0 Yqey-like protein MAP17 PF15807.5 EFA77350.1 - 0.0018 18.5 0.3 0.0046 17.2 0.3 1.6 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FAM176 PF14851.6 EFA77350.1 - 0.008 15.8 0.4 0.017 14.8 0.4 1.5 1 0 0 1 1 1 1 FAM176 family TMEM154 PF15102.6 EFA77350.1 - 0.035 14.0 0.6 0.1 12.5 0.1 2.0 2 0 0 2 2 2 0 TMEM154 protein family Conotoxin PF02950.17 EFA77350.1 - 0.051 14.6 0.4 0.15 13.1 0.4 1.8 1 0 0 1 1 1 0 Conotoxin EphA2_TM PF14575.6 EFA77350.1 - 0.072 14.0 0.1 0.25 12.3 0.1 2.0 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UPF0542 PF15086.6 EFA77350.1 - 0.16 11.9 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF2615 PF11027.8 EFA77350.1 - 0.18 12.0 0.7 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) TLD PF07534.16 EFA77351.1 - 1.6e-21 77.0 4.2 3.1e-21 76.1 4.2 1.5 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFA77351.1 - 8.7e-21 74.1 0.0 2e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain vWF_A PF12450.8 EFA77351.1 - 0.054 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor BTB_3 PF16017.5 EFA77351.1 - 0.079 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain DUF2179 PF10035.9 EFA77351.1 - 0.1 12.4 0.5 0.68 9.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2179) TIG PF01833.24 EFA77352.1 - 2.3e-27 94.9 159.8 8.3e-07 29.0 2.3 17.8 15 2 4 19 19 19 14 IPT/TIG domain EGF_2 PF07974.13 EFA77352.1 - 4.3e-07 30.2 30.1 0.0011 19.2 10.7 2.6 2 0 0 2 2 2 2 EGF-like domain EGF PF00008.27 EFA77352.1 - 0.054 13.8 23.2 0.16 12.3 6.0 2.7 2 0 0 2 2 2 0 EGF-like domain DUF2157 PF09925.9 EFA77353.1 - 0.042 13.7 1.8 0.059 13.2 1.2 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Abhydrolase_9_N PF15420.6 EFA77353.1 - 0.09 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Virul_fac_BrkB PF03631.15 EFA77353.1 - 0.78 9.3 12.9 0.23 11.1 9.4 1.6 1 1 1 2 2 2 0 Virulence factor BrkB DUF4293 PF14126.6 EFA77353.1 - 4.2 7.6 15.7 17 5.7 15.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) NB PF04159.13 EFA77353.1 - 6.3 6.9 6.7 1.6 8.8 3.1 1.7 1 1 1 2 2 2 0 NB glycoprotein SNF2_N PF00176.23 EFA77354.1 - 1.7e-68 230.9 0.8 3.4e-68 229.9 0.8 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA77354.1 - 3.8e-20 72.3 2.1 4.5e-20 72.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 EFA77354.1 - 4e-20 71.5 7.0 1.3e-10 41.0 0.7 3.5 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 EFA77354.1 - 3.8e-19 68.9 2.9 3.8e-19 68.9 2.9 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) ResIII PF04851.15 EFA77354.1 - 1.5e-14 54.4 5.3 4.7e-14 52.8 0.0 3.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SLIDE PF09111.10 EFA77354.1 - 0.0044 17.0 0.0 0.0044 17.0 0.0 4.6 5 0 0 5 5 5 1 SLIDE CDH1_2_SANT_HL1 PF18375.1 EFA77354.1 - 0.017 15.8 1.0 0.017 15.8 1.0 3.8 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Myb_DNA-binding PF00249.31 EFA77354.1 - 0.092 12.9 0.0 0.35 11.1 0.0 2.0 1 0 0 1 1 1 0 Myb-like DNA-binding domain FF PF01846.19 EFA77355.1 - 3.7e-33 113.5 25.8 4.4e-11 42.8 0.1 7.2 7 0 0 7 7 7 5 FF domain WW PF00397.26 EFA77355.1 - 5.7e-20 71.1 10.7 2.2e-10 40.5 5.0 3.0 3 0 0 3 3 3 2 WW domain IgG_binding_B PF01378.17 EFA77355.1 - 0.002 18.1 0.9 0.006 16.6 0.0 2.3 3 0 0 3 3 3 1 B domain Fringe PF02434.16 EFA77356.1 - 4.1e-10 39.5 0.3 2.4e-08 33.8 0.3 2.2 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EFA77356.1 - 0.00031 20.6 0.8 0.0012 18.7 0.0 2.4 4 0 0 4 4 4 1 Galactosyltransferase Cse1 PF08506.10 EFA77358.1 - 1e-87 294.4 5.2 1.6e-70 237.8 3.4 2.3 1 1 1 2 2 2 2 Cse1 CAS_CSE1 PF03378.15 EFA77358.1 - 4e-53 180.5 6.5 2.1e-29 102.3 1.8 2.4 1 1 1 2 2 2 2 CAS/CSE protein, C-terminus IBN_N PF03810.19 EFA77358.1 - 1.9e-12 46.9 0.2 6.1e-12 45.3 0.2 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFA77358.1 - 0.00024 21.2 8.3 0.007 16.4 3.6 4.0 2 1 1 3 3 3 1 Exportin 1-like protein Methyltransf_4 PF02390.17 EFA77358.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Kelch_6 PF13964.6 EFA77359.1 - 7.2e-18 64.2 4.2 1.4e-08 34.7 0.0 5.5 4 1 1 5 5 5 4 Kelch motif zf-B_box PF00643.24 EFA77359.1 - 3.1e-05 24.0 10.9 6.2e-05 23.1 10.9 1.5 1 0 0 1 1 1 1 B-box zinc finger Mem_trans PF03547.18 EFA77360.1 - 0.1 11.0 5.6 0.021 13.2 1.5 1.8 1 1 1 2 2 2 0 Membrane transport protein SH PF01445.17 EFA77360.1 - 0.7 9.9 4.5 0.62 10.1 0.6 2.6 2 0 0 2 2 2 0 Viral small hydrophobic protein BaxI_1 PF12811.7 EFA77360.1 - 0.91 9.0 6.1 0.71 9.4 0.9 2.5 3 0 0 3 3 3 0 Bax inhibitor 1 like 7tm_1 PF00001.21 EFA77360.1 - 3.7 6.8 8.8 8.8 5.6 5.9 2.3 2 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF3139 PF11337.8 EFA77360.1 - 6.7 7.4 0.0 6.7 7.4 0.0 4.0 3 2 0 3 3 3 0 Protein of unknown function (DUF3139) DUF4833 PF16117.5 EFA77361.1 - 0.0091 16.0 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4833) SprB PF13573.6 EFA77361.1 - 0.28 11.0 0.1 0.28 11.0 0.1 5.3 6 0 0 6 6 6 0 SprB repeat Aldo_ket_red PF00248.21 EFA77363.1 - 1.5e-46 158.9 0.0 2.3e-44 151.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Metallophos_C PF14008.6 EFA77364.1 - 1.3e-22 80.4 4.2 2.6e-22 79.5 0.7 3.1 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EFA77364.1 - 1.2e-16 61.1 0.0 3.3e-16 59.6 0.0 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EFA77364.1 - 4.3e-16 60.0 2.6 4.3e-16 60.0 2.6 1.8 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase fn3_PAP PF17808.1 EFA77364.1 - 0.11 12.7 1.5 9.1 6.4 1.5 3.2 1 1 0 1 1 1 0 Fn3-like domain from Purple Acid Phosphatase tRNA_synt_1c_R1 PF04558.15 EFA77365.1 - 0.051 13.6 0.0 0.058 13.4 0.0 1.1 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Actin PF00022.19 EFA77366.1 - 4.8e-152 506.3 0.0 1.5e-151 504.6 0.0 1.6 1 1 0 1 1 1 1 Actin Cpn60_TCP1 PF00118.24 EFA77371.1 - 3.6e-49 167.7 25.6 2.7e-26 92.3 3.1 2.7 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Med15 PF09606.10 EFA77371.1 - 0.026 13.2 28.4 0.04 12.6 18.8 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal RskA PF10099.9 EFA77371.1 - 0.33 11.2 4.3 0.53 10.6 3.5 1.6 2 0 0 2 2 2 0 Anti-sigma-K factor rskA BORG_CEP PF14957.6 EFA77371.1 - 0.84 10.8 0.1 0.84 10.8 0.1 4.3 3 1 0 3 3 3 0 Cdc42 effector Helicase_RecD PF05127.14 EFA77371.1 - 1.4 8.8 7.5 6.5 6.6 0.1 2.8 2 0 0 2 2 2 0 Helicase DUF4175 PF13779.6 EFA77371.1 - 5.7 4.7 26.7 0.38 8.6 20.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) PepSY_TM PF03929.16 EFA77371.1 - 7.6 6.1 5.5 3.2 7.3 1.0 2.4 3 0 0 3 3 3 0 PepSY-associated TM region Yip1 PF04893.17 EFA77372.1 - 5.1e-16 58.9 19.7 6.6e-16 58.5 19.7 1.1 1 0 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 EFA77372.1 - 0.0018 18.1 8.2 0.0024 17.7 8.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) DUF2070 PF09843.9 EFA77372.1 - 3.5 5.8 13.9 4.3 5.5 13.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ABC2_membrane PF01061.24 EFA77373.1 - 1e-68 230.9 50.6 7.7e-41 139.8 17.5 3.8 3 1 1 4 4 4 3 ABC-2 type transporter ABC_tran PF00005.27 EFA77373.1 - 2.2e-33 115.7 0.0 1.1e-20 74.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFA77373.1 - 2.5e-10 40.1 1.8 9.3e-05 22.3 0.6 3.1 2 0 0 2 2 2 2 CDR ABC transporter PDR_assoc PF08370.11 EFA77373.1 - 8.4e-09 35.1 0.4 2.1e-07 30.6 0.0 3.0 2 0 0 2 2 2 1 Plant PDR ABC transporter associated AAA_21 PF13304.6 EFA77373.1 - 1.1e-08 35.3 0.0 0.036 13.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA77373.1 - 0.00086 19.0 0.1 0.0023 17.6 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFA77373.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EFA77373.1 - 0.012 15.9 0.0 0.044 14.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFA77373.1 - 0.014 15.3 0.0 0.043 13.7 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 EFA77373.1 - 0.029 14.8 0.0 0.053 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFA77373.1 - 0.046 14.3 0.0 0.13 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFA77373.1 - 0.074 12.8 0.0 0.77 9.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 EFA77373.1 - 0.084 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase AAA_23 PF13476.6 EFA77373.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC2_membrane_2 PF12679.7 EFA77373.1 - 0.51 9.6 13.1 0.025 13.9 5.2 2.5 2 1 0 2 2 2 0 ABC-2 family transporter protein P34-Arc PF04045.14 EFA77374.1 - 1.4e-82 277.1 0.0 1.6e-82 276.8 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Pterin_4a PF01329.19 EFA77375.1 - 5e-31 106.7 0.1 5.5e-31 106.6 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase SRF-TF PF00319.18 EFA77376.1 - 4.9e-18 64.3 0.1 8.1e-18 63.6 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF1447 PF07288.11 EFA77376.1 - 0.33 11.0 5.8 1.1 9.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1447) AviRa PF11599.8 EFA77376.1 - 0.9 8.9 7.4 1.6 8.2 7.4 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Fe-ADH PF00465.19 EFA77378.1 - 1.8e-89 300.1 0.0 2.6e-89 299.6 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFA77378.1 - 4e-09 36.5 0.0 6.5e-05 22.7 0.0 2.5 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase BORA_N PF15280.6 EFA77378.1 - 0.0018 18.0 0.4 0.0027 17.4 0.4 1.2 1 0 0 1 1 1 1 Protein aurora borealis N-terminus Dehydrin PF00257.19 EFA77378.1 - 0.44 11.1 2.1 0.89 10.1 2.1 1.5 1 0 0 1 1 1 0 Dehydrin Pkinase PF00069.25 EFA77379.1 - 7e-67 225.6 0.3 1.5e-66 224.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Calpain_III PF01067.22 EFA77379.1 - 7.4e-50 168.9 5.8 1.6e-16 60.9 0.0 5.4 6 1 0 6 6 6 4 Calpain large subunit, domain III Pkinase_Tyr PF07714.17 EFA77379.1 - 1.6e-48 165.3 0.0 2.5e-48 164.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA77379.1 - 0.00023 20.0 1.4 0.00035 19.5 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase TFIIF_alpha PF05793.12 EFA77379.1 - 0.00073 18.3 8.7 0.00073 18.3 8.7 2.3 3 0 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ABC1 PF03109.16 EFA77379.1 - 0.085 13.0 0.0 0.41 10.8 0.0 2.0 2 0 0 2 2 2 0 ABC1 family Abi_2 PF07751.11 EFA77379.1 - 2.1 8.5 6.1 0.26 11.5 0.2 2.3 3 0 0 3 3 3 0 Abi-like protein Frataxin_Cyay PF01491.16 EFA77381.1 - 0.023 14.8 0.1 0.039 14.0 0.1 1.4 1 0 0 1 1 1 0 Frataxin-like domain RVT_1 PF00078.27 EFA77382.1 - 2.5e-34 118.7 0.0 4.5e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 EFA77382.1 - 1.4e-05 24.8 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DcpS_C PF11969.8 EFA77384.1 - 1.1e-28 100.0 4.7 2.1e-28 99.1 4.7 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EFA77384.1 - 1e-16 61.5 0.8 2.3e-16 60.3 0.8 1.6 1 0 0 1 1 1 1 HIT domain zf-C2HE PF16278.5 EFA77384.1 - 5.5e-08 33.1 2.7 6.2e-08 33.0 0.4 2.4 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger FHA PF00498.26 EFA77384.1 - 0.031 14.6 0.3 0.29 11.5 0.1 2.4 2 0 0 2 2 2 0 FHA domain DUF5427 PF10310.9 EFA77384.1 - 0.064 12.2 5.4 0.095 11.6 5.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) zf-C2H2_4 PF13894.6 EFA77384.1 - 0.26 12.2 1.4 1.1 10.3 1.4 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger FYDLN_acid PF09538.10 EFA77384.1 - 0.27 11.9 0.2 0.27 11.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF1296 PF06972.11 EFA77385.1 - 0.001 19.2 0.1 0.0022 18.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) CUE PF02845.16 EFA77385.1 - 0.087 12.5 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 CUE domain Calpain_III PF01067.22 EFA77386.1 - 1.4e-37 129.0 1.4 1.7e-16 60.8 0.1 3.7 4 1 0 4 4 4 3 Calpain large subunit, domain III C2 PF00168.30 EFA77386.1 - 5.2e-07 29.9 0.4 9.6e-06 25.8 0.1 2.9 3 0 0 3 3 3 1 C2 domain GATA PF00320.27 EFA77387.1 - 1.2e-12 47.2 3.0 1.2e-12 47.2 3.0 2.1 2 0 0 2 2 2 1 GATA zinc finger CTU2 PF10288.9 EFA77387.1 - 1.3 9.3 9.6 84 3.5 9.5 2.9 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 RIC1 PF07064.13 EFA77388.1 - 7.7e-28 97.6 0.0 1.4e-27 96.7 0.0 1.4 1 0 0 1 1 1 1 RIC1 AAA PF00004.29 EFA77390.1 - 2.2e-12 47.5 0.4 7.1e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFA77390.1 - 7.4e-12 45.7 0.2 3.2e-11 43.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA77390.1 - 9.3e-07 29.4 0.0 3.7e-06 27.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EFA77390.1 - 5.9e-06 25.8 0.0 1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Cdc6_C PF09079.11 EFA77390.1 - 2.2e-05 24.3 0.7 0.00015 21.7 0.0 2.5 3 0 0 3 3 2 1 CDC6, C terminal winged helix domain AAA_24 PF13479.6 EFA77390.1 - 3.4e-05 23.7 0.2 0.0002 21.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EFA77390.1 - 0.00016 21.2 0.0 0.00032 20.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_7 PF12775.7 EFA77390.1 - 0.00041 19.9 0.6 0.00041 19.9 0.6 1.7 2 0 0 2 2 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 EFA77390.1 - 0.0015 18.9 0.4 0.0044 17.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 EFA77390.1 - 0.0018 18.4 0.1 0.004 17.2 0.1 1.6 1 0 0 1 1 1 1 Torsin RNA_helicase PF00910.22 EFA77390.1 - 0.0041 17.5 0.9 0.013 15.9 0.3 2.4 2 1 0 2 2 1 1 RNA helicase AAA_32 PF13654.6 EFA77390.1 - 0.0042 15.9 0.0 0.0073 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.7 EFA77390.1 - 0.0059 15.6 0.2 0.022 13.7 0.1 1.9 2 0 0 2 2 2 1 AAA-like domain PIF1 PF05970.14 EFA77390.1 - 0.0061 15.8 1.0 0.019 14.2 0.1 2.1 2 0 0 2 2 2 1 PIF1-like helicase GvpD PF07088.11 EFA77390.1 - 0.0067 15.1 0.1 0.012 14.3 0.1 1.3 1 0 0 1 1 1 1 GvpD gas vesicle protein EF-hand_2 PF09068.11 EFA77390.1 - 0.012 15.8 1.8 2.2 8.4 0.3 2.7 2 1 0 2 2 2 0 EF hand FtsK_SpoIIIE PF01580.18 EFA77390.1 - 0.012 15.0 0.1 0.036 13.4 0.1 1.6 1 1 1 2 2 2 0 FtsK/SpoIIIE family DNA_pol3_delta2 PF13177.6 EFA77390.1 - 0.014 15.2 1.6 0.022 14.5 0.2 1.9 2 0 0 2 2 2 0 DNA polymerase III, delta subunit AAA_11 PF13086.6 EFA77390.1 - 0.024 14.4 0.1 0.067 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFA77390.1 - 0.025 14.3 0.0 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Rad17 PF03215.15 EFA77390.1 - 0.032 14.1 1.6 0.042 13.8 0.3 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 EFA77390.1 - 0.035 14.0 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Zot PF05707.12 EFA77390.1 - 0.037 13.7 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_25 PF13481.6 EFA77390.1 - 0.045 13.3 0.0 0.11 12.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain DEAD PF00270.29 EFA77390.1 - 0.079 12.7 2.3 2.3 8.0 0.3 2.5 1 1 1 2 2 2 0 DEAD/DEAH box helicase Zeta_toxin PF06414.12 EFA77390.1 - 0.082 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Myb_DNA-bind_7 PF15963.5 EFA77390.1 - 0.088 12.7 0.2 0.26 11.2 0.2 1.8 1 0 0 1 1 1 0 Myb DNA-binding like AAA_lid_10 PF17872.1 EFA77390.1 - 0.09 12.9 0.1 0.35 11.0 0.1 2.0 1 0 0 1 1 1 0 AAA lid domain T2SSE PF00437.20 EFA77390.1 - 0.11 11.6 0.2 0.18 10.8 0.2 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 EFA77390.1 - 0.13 12.3 1.4 0.7 9.9 0.4 2.4 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit Tail_P2_I PF09684.10 EFA77390.1 - 0.17 11.8 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Phage tail protein (Tail_P2_I) ATPase PF06745.13 EFA77390.1 - 0.19 11.1 3.6 0.72 9.1 0.1 2.8 2 1 1 3 3 3 0 KaiC DUF87 PF01935.17 EFA77390.1 - 0.31 11.1 2.9 0.54 10.3 0.3 2.4 2 1 1 3 3 3 0 Helicase HerA, central domain NAC PF01849.18 EFA77391.1 - 2.8e-17 62.4 0.4 7.6e-17 61.0 0.0 2.0 2 0 0 2 2 2 1 NAC domain DUF2163 PF09931.9 EFA77391.1 - 0.033 14.4 0.1 0.042 14.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) AP3D1 PF06375.11 EFA77391.1 - 0.092 13.0 3.4 0.14 12.3 2.3 1.8 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Mucin PF01456.17 EFA77391.1 - 1.9 8.5 13.8 1.2 9.1 7.7 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3439 PF11921.8 EFA77391.1 - 5.3 7.0 7.6 2.9 7.9 2.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) TT_ORF2 PF02957.15 EFA77391.1 - 5.3 8.0 7.9 0.5 11.3 2.7 1.8 2 0 0 2 2 2 0 TT viral ORF2 Alba PF01918.21 EFA77392.1 - 2e-10 40.4 0.0 3.4e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Alba SOG2 PF10428.9 EFA77392.1 - 1.4 8.0 5.2 2 7.5 5.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein TTL PF03133.15 EFA77393.1 - 6.4e-58 196.2 3.3 6.4e-58 196.2 3.3 1.8 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.14 EFA77393.1 - 0.0021 18.1 0.0 0.083 12.9 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EFA77393.1 - 0.029 13.6 0.0 0.56 9.4 0.0 2.4 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp QRPTase_C PF01729.19 EFA77393.1 - 0.3 10.8 3.0 6 6.6 0.0 2.3 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain TTL PF03133.15 EFA77394.1 - 5.3e-55 186.6 1.8 9.1e-55 185.9 1.8 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.14 EFA77394.1 - 0.031 14.3 0.0 0.08 13.0 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_YheCD PF14398.6 EFA77394.1 - 0.038 13.2 0.1 1.7 7.8 0.0 2.7 2 1 0 2 2 2 0 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFA77394.1 - 0.043 13.1 0.0 3.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp TFIIA PF03153.13 EFA77395.1 - 7.9e-10 39.3 41.6 7.9e-10 39.3 41.6 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit bZIP_1 PF00170.21 EFA77395.1 - 2.2e-05 24.4 12.3 2.2e-05 24.4 12.3 2.8 2 0 0 2 2 2 1 bZIP transcription factor Mitofilin PF09731.9 EFA77395.1 - 0.0011 18.0 22.3 0.0024 16.8 22.3 1.6 1 0 0 1 1 1 1 Mitochondrial inner membrane protein bZIP_2 PF07716.15 EFA77395.1 - 0.0085 16.2 18.1 0.0085 16.2 18.1 3.3 2 2 0 2 2 2 1 Basic region leucine zipper DUF3439 PF11921.8 EFA77395.1 - 1.6 8.7 15.0 1.1 9.2 11.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Macoilin PF09726.9 EFA77395.1 - 2.8 6.4 30.3 0.052 12.1 18.1 2.2 2 0 0 2 2 2 0 Macoilin family SIR2_2 PF13289.6 EFA77396.1 - 1.2e-25 90.3 0.1 4.8e-25 88.3 0.0 2.1 2 0 0 2 2 2 1 SIR2-like domain FNIP PF05725.12 EFA77397.1 - 1.3e-34 118.1 19.7 1.5e-12 47.5 1.1 8.3 3 1 6 9 9 9 8 FNIP Repeat LRR_4 PF12799.7 EFA77397.1 - 1 9.9 13.8 14 6.3 0.6 6.3 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) fn3 PF00041.21 EFA77398.1 - 1.4e-33 115.0 52.4 0.0024 18.2 1.1 14.5 12 2 1 13 13 13 10 Fibronectin type III domain Tissue_fac PF01108.17 EFA77398.1 - 7.6e-10 38.6 19.3 0.0025 17.7 1.0 8.3 8 1 0 8 8 8 2 Tissue factor EGF_2 PF07974.13 EFA77398.1 - 1.1e-05 25.7 9.0 4.8e-05 23.6 9.0 2.3 1 0 0 1 1 1 1 EGF-like domain I-EGF_1 PF18372.1 EFA77398.1 - 0.0019 18.2 6.9 0.0079 16.3 6.9 2.1 1 0 0 1 1 1 1 Integrin beta epidermal growth factor like domain 1 DUF2369 PF10179.9 EFA77398.1 - 0.0037 17.6 41.2 6.4 7.2 0.1 10.0 9 1 1 10 10 10 3 Uncharacterised conserved protein (DUF2369) EGF PF00008.27 EFA77398.1 - 0.025 14.9 5.5 0.12 12.7 5.5 2.3 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 EFA77398.1 - 0.11 12.8 4.9 0.13 12.6 1.4 3.0 2 0 0 2 2 2 0 EB module Pur_ac_phosph_N PF16656.5 EFA77398.1 - 0.15 12.7 62.1 0.54 10.9 0.0 12.0 8 5 3 11 11 11 0 Purple acid Phosphatase, N-terminal domain ObR_Ig PF18589.1 EFA77398.1 - 2.6 8.5 16.0 5.2 7.5 0.1 7.0 8 0 0 8 8 8 0 Obesity receptor immunoglobulin like domain ketoacyl-synt PF00109.26 EFA77399.1 - 1.5e-69 234.4 0.0 2.3e-69 233.8 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA77399.1 - 1.7e-55 188.8 0.0 2.4e-55 188.3 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA77399.1 - 2.8e-35 120.9 0.1 6.5e-35 119.7 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA77399.1 - 8.6e-34 117.0 0.0 1.2e-32 113.2 0.0 2.6 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 EFA77399.1 - 2.3e-23 82.9 0.0 9.6e-23 80.9 0.0 1.8 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA77399.1 - 1.8e-16 60.6 0.0 5.1e-16 59.1 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA77399.1 - 1.5e-14 54.5 0.0 5.6e-14 52.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA77399.1 - 6.9e-10 38.7 0.0 2.4e-07 30.4 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase ADH_zinc_N PF00107.26 EFA77399.1 - 8e-08 32.3 0.0 2.5e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA77399.1 - 2.5e-07 31.8 0.0 7.6e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFA77399.1 - 4.5e-07 29.9 0.0 1.5e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA77399.1 - 1.5e-05 25.6 0.0 0.00015 22.4 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA77399.1 - 2e-05 25.2 0.0 0.0002 22.0 0.0 2.8 3 0 0 3 3 2 1 Methyltransferase domain ADH_N PF08240.12 EFA77399.1 - 8.9e-05 22.3 0.0 0.00021 21.2 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.6 EFA77399.1 - 0.00014 21.5 0.0 0.00031 20.4 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFA77399.1 - 0.002 18.0 0.3 0.014 15.2 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain DUF938 PF06080.12 EFA77399.1 - 0.006 16.4 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Thiolase_N PF00108.23 EFA77399.1 - 0.022 14.1 0.0 0.046 13.1 0.0 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain Methyltransf_16 PF10294.9 EFA77399.1 - 0.036 13.8 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Lysine methyltransferase Sec7_N PF12783.7 EFA77400.1 - 0.08 12.8 2.3 1.4 8.8 0.1 2.9 2 1 1 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT PF02985.22 EFA77401.1 - 9.7e-05 22.3 0.1 0.11 12.8 0.0 3.5 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 EFA77401.1 - 0.00063 20.1 0.0 4.6 7.7 0.0 3.6 2 1 1 3 3 3 2 HEAT repeats RTP1_C1 PF10363.9 EFA77401.1 - 2.5 8.3 6.4 7.6 6.8 0.0 4.9 6 1 1 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 eIF3_p135 PF12807.7 EFA77401.1 - 3.2 7.8 7.3 8.6 6.4 0.5 3.4 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit 135 zf-C3HC4_3 PF13920.6 EFA77402.1 - 0.27 11.1 1.5 0.82 9.6 1.5 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EFA77402.1 - 1.1 9.0 4.1 3.6 7.3 4.1 1.7 1 1 0 1 1 1 0 P-11 zinc finger BUD22 PF09073.10 EFA77402.1 - 4.1 6.6 53.7 0.7 9.2 9.0 3.1 3 0 0 3 3 3 0 BUD22 CH PF00307.31 EFA77404.1 - 1e-33 115.7 9.1 8e-12 45.3 0.0 5.9 5 0 0 5 5 5 4 Calponin homology (CH) domain 7tm_3 PF00003.22 EFA77404.1 - 6.5e-05 22.8 1.1 0.00014 21.7 1.1 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Tfb5 PF06331.12 EFA77404.1 - 0.5 10.4 0.0 0.5 10.4 0.0 5.8 5 1 0 5 5 5 0 Transcription factor TFIIH complex subunit Tfb5 U3snoRNP10 PF12397.8 EFA77404.1 - 1.9 8.9 8.4 0.27 11.6 1.9 3.1 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 7tm_3 PF00003.22 EFA77405.1 - 2.5e-28 99.4 28.9 2.5e-28 99.4 28.9 2.2 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Claudin_2 PF13903.6 EFA77405.1 - 0.67 9.7 6.8 0.15 11.8 2.3 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Tmemb_18A PF09771.9 EFA77405.1 - 9.9 6.6 10.7 0.44 10.9 1.0 3.5 2 1 1 3 3 3 0 Transmembrane protein 188 Clat_adaptor_s PF01217.20 EFA77406.1 - 3.1e-08 33.6 2.4 3.8e-08 33.4 2.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1084 PF06454.11 EFA77408.1 - 7.6e-11 41.9 26.8 1.8e-10 40.7 26.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1084) G10 PF01125.17 EFA77409.1 - 2.7e-63 212.1 8.5 3.3e-63 211.8 8.5 1.0 1 0 0 1 1 1 1 G10 protein FNIP PF05725.12 EFA77410.1 - 7.7e-18 64.4 8.9 6.1e-12 45.5 0.5 3.7 3 0 0 3 3 3 2 FNIP Repeat FNIP PF05725.12 EFA77411.1 - 5.9e-53 176.8 43.1 1.1e-13 51.1 0.5 9.6 10 1 1 11 11 11 7 FNIP Repeat LRR_5 PF13306.6 EFA77411.1 - 0.011 15.8 3.3 0.048 13.6 0.1 3.3 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) CHIPS PF11434.8 EFA77411.1 - 0.013 15.3 0.5 0.029 14.2 0.5 1.5 1 0 0 1 1 1 0 Chemotaxis-inhibiting protein CHIPS CAP_C PF08603.11 EFA77411.1 - 0.056 13.1 3.6 0.079 12.6 0.8 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) C terminal Pkinase PF00069.25 EFA77412.1 - 4e-77 259.1 0.0 4.9e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77412.1 - 2e-38 132.2 0.0 2.7e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA77412.1 - 5.7e-08 32.4 0.0 9e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFA77412.1 - 0.002 18.1 0.0 0.0065 16.4 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFA77412.1 - 0.0091 15.6 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EFA77412.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFA77412.1 - 0.027 14.1 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Ribul_P_3_epim PF00834.19 EFA77413.1 - 3.5e-58 196.3 0.0 5.1e-58 195.7 0.0 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family PEP_mutase PF13714.6 EFA77413.1 - 0.0091 15.5 0.0 0.63 9.5 0.0 2.5 2 1 0 2 2 2 1 Phosphoenolpyruvate phosphomutase RNaseH_like PF04308.12 EFA77413.1 - 0.072 13.0 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Ribonuclease H-like PdxJ PF03740.13 EFA77413.1 - 0.076 12.1 0.0 0.18 10.9 0.0 1.6 1 1 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ M20_dimer PF07687.14 EFA77413.1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase dimerisation domain ECH_1 PF00378.20 EFA77414.1 - 4.7e-87 291.5 1.6 6.7e-87 290.9 1.6 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFA77414.1 - 3.6e-42 145.0 1.7 2.1e-37 129.4 0.4 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase BTG PF07742.12 EFA77414.1 - 1.3e-20 73.4 0.0 2.7e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 BTG family Peptidase_S49 PF01343.18 EFA77414.1 - 0.058 13.4 0.4 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 DUF4551 PF15087.6 EFA77414.1 - 3 6.6 8.6 5.1 5.8 8.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SdrD_B PF17210.3 EFA77415.1 - 1.4e-16 60.7 2.5 5.2e-07 29.9 0.3 3.1 3 0 0 3 3 3 2 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA77415.1 - 2.2e-08 34.2 0.7 0.01 16.1 0.1 2.8 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA77415.1 - 0.00011 22.5 5.2 0.1 12.9 0.0 3.6 3 0 0 3 3 3 2 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA77415.1 - 0.0028 17.6 5.6 0.98 9.5 1.8 3.1 2 1 0 2 2 2 2 CarboxypepD_reg-like domain Pollen_Ole_e_I PF01190.17 EFA77415.1 - 0.032 14.6 0.0 7.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Pollen proteins Ole e I like DUF2012 PF09430.10 EFA77415.1 - 0.034 14.3 0.7 1.6 8.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) Big_1 PF02369.16 EFA77415.1 - 0.051 13.6 0.0 2.9 8.0 0.0 2.9 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) Ras PF00071.22 EFA77416.1 - 3.1e-64 215.5 0.3 3.5e-64 215.3 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA77416.1 - 7.2e-36 123.0 0.3 1.3e-35 122.2 0.3 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA77416.1 - 1.1e-18 67.2 0.1 1.4e-18 67.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA77416.1 - 8.4e-07 29.0 0.2 0.019 14.9 0.1 2.3 2 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFA77416.1 - 1.4e-06 27.8 0.1 1.7e-06 27.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFA77416.1 - 1.4e-05 24.7 0.4 4.9e-05 23.0 0.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA77416.1 - 2.2e-05 24.5 0.0 4.3e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA77416.1 - 4.6e-05 22.9 0.0 8.3e-05 22.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 EFA77416.1 - 0.00066 20.1 0.0 1 9.8 0.0 2.3 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 EFA77416.1 - 0.00069 19.2 0.1 0.19 11.2 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B LepB_N PF18640.1 EFA77416.1 - 0.025 14.2 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 LepB N-terminal domain AAA_29 PF13555.6 EFA77416.1 - 0.039 13.7 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EFA77416.1 - 0.05 13.5 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EFA77416.1 - 0.055 13.9 0.0 0.11 12.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFA77416.1 - 0.059 13.6 0.0 0.16 12.2 0.0 1.9 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EFA77416.1 - 0.097 12.1 0.0 0.28 10.6 0.0 1.7 2 1 1 3 3 3 0 Bacterial TniB protein ABC_tran PF00005.27 EFA77416.1 - 0.098 13.2 0.2 0.17 12.4 0.2 1.6 1 1 0 1 1 1 0 ABC transporter VPS9 PF02204.18 EFA77417.1 - 6.6e-31 106.6 0.2 1.3e-30 105.7 0.2 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EFA77417.1 - 2.4e-11 43.8 0.0 1.8e-10 41.0 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) CENP-U PF13097.6 EFA77417.1 - 1.7 8.5 10.6 4.7 7.1 10.6 1.7 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit SKA1 PF07160.12 EFA77417.1 - 3.9 7.2 11.1 15 5.3 11.1 2.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Spt20 PF12090.8 EFA77417.1 - 9.1 5.8 31.5 5.7 6.5 23.3 2.4 2 0 0 2 2 2 0 Spt20 family XPG_N PF00752.17 EFA77418.1 - 1.6e-32 111.9 0.0 3.3e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EFA77418.1 - 6.3e-29 100.2 0.0 1.4e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EFA77418.1 - 0.00018 22.0 0.0 0.0011 19.5 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold DUF3231 PF11553.8 EFA77418.1 - 0.027 14.1 0.4 0.1 12.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) PEMT PF04191.13 EFA77419.1 - 7.3e-30 103.5 4.5 7.3e-30 103.5 4.5 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase Steroid_dh PF02544.16 EFA77419.1 - 0.14 12.1 3.9 0.17 11.9 0.6 2.4 2 1 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase CAF1C_H4-bd PF12265.8 EFA77420.1 - 2.2e-28 98.3 3.3 5.9e-28 96.9 1.7 2.6 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFA77420.1 - 1.8e-18 66.5 5.3 2.8e-07 31.1 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat DUF4209 PF13910.6 EFA77420.1 - 3.2e-05 24.1 3.4 0.19 12.0 0.0 4.4 4 0 0 4 4 4 2 Domain of unknown function (DUF4209) SUIM_assoc PF16619.5 EFA77420.1 - 0.0057 16.7 2.2 0.0057 16.7 2.2 4.9 5 1 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 ANAPC4_WD40 PF12894.7 EFA77420.1 - 0.031 14.6 0.2 1.6 9.1 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF43 PF01861.16 EFA77420.1 - 0.094 11.9 1.1 0.27 10.4 1.1 1.8 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain PBAN PF05874.11 EFA77420.1 - 0.19 11.6 0.6 6.2 6.7 0.1 2.4 2 0 0 2 2 2 0 Pheromone biosynthesis activating neuropeptide (PBAN) OapA_N PF08525.11 EFA77421.1 - 0.00014 21.7 1.4 0.0002 21.2 1.4 1.2 1 0 0 1 1 1 1 Opacity-associated protein A N-terminal motif ketoacyl-synt PF00109.26 EFA77422.1 - 3.1e-69 233.4 0.0 4.7e-69 232.8 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA77422.1 - 1.1e-55 189.5 0.0 1.5e-55 188.9 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA77422.1 - 2.1e-35 121.3 0.1 5e-35 120.1 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA77422.1 - 6.5e-33 114.2 0.0 9.4e-32 110.4 0.0 2.6 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 EFA77422.1 - 1.2e-23 83.9 0.0 1.8e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA77422.1 - 2.5e-17 63.3 0.1 7.6e-17 61.8 0.1 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA77422.1 - 1.9e-14 54.2 0.0 8.5e-14 52.1 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA77422.1 - 5.4e-11 42.3 0.0 2.5e-08 33.6 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EFA77422.1 - 7.4e-10 40.0 0.0 2e-09 38.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFA77422.1 - 2e-07 31.0 0.0 5.4e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFA77422.1 - 1.8e-06 27.9 0.0 4.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EFA77422.1 - 1.2e-05 25.1 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_11 PF08241.12 EFA77422.1 - 3.5e-05 24.4 0.0 0.0002 21.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA77422.1 - 3.7e-05 24.3 0.0 0.00035 21.2 0.0 2.7 3 0 0 3 3 2 1 Methyltransferase domain adh_short_C2 PF13561.6 EFA77422.1 - 0.00022 20.9 0.0 0.00047 19.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFA77422.1 - 0.00086 19.1 0.4 0.0075 16.1 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain DUF938 PF06080.12 EFA77422.1 - 0.0034 17.2 0.0 0.009 15.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 EFA77422.1 - 0.0082 15.9 0.1 0.032 14.0 0.0 2.0 2 0 0 2 2 1 1 Lysine methyltransferase Thiolase_N PF00108.23 EFA77422.1 - 0.016 14.6 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Semialdhyde_dh PF01118.24 EFA77422.1 - 0.12 12.8 0.1 3.5 8.1 0.0 2.9 3 0 0 3 3 2 0 Semialdehyde dehydrogenase, NAD binding domain Izumo-Ig PF16706.5 EFA77423.1 - 0.068 13.2 0.1 0.077 13.1 0.1 1.1 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Chromo PF00385.24 EFA77425.1 - 2e-10 40.4 2.8 4.4e-10 39.3 2.8 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EFA77425.1 - 9.1e-08 32.3 0.0 0.00049 20.3 0.0 2.4 1 1 1 2 2 2 2 Integrase core domain HTH_Tnp_Tc5 PF03221.16 EFA77426.1 - 0.1 12.6 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain FAM176 PF14851.6 EFA77428.1 - 0.059 13.0 0.0 0.059 13.0 0.0 2.5 1 1 0 2 2 2 0 FAM176 family GvpO PF05800.11 EFA77428.1 - 0.46 10.5 3.5 0.27 11.2 1.1 1.8 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpO Suv3_N PF18114.1 EFA77428.1 - 0.5 10.5 7.7 0.14 12.3 0.9 2.8 2 1 1 3 3 3 0 Suv3 helical N-terminal domain DUF4398 PF14346.6 EFA77428.1 - 1.1 9.9 9.1 2 9.1 9.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) ATPase_2 PF01637.18 EFA77430.1 - 0.0018 18.3 4.0 0.0018 18.3 4.0 2.9 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_35 PF14516.6 EFA77430.1 - 0.0069 15.3 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain Ponericin PF07442.11 EFA77430.1 - 0.47 10.5 6.1 1.1 9.3 6.1 1.7 1 0 0 1 1 1 0 Ponericin Serinc PF03348.15 EFA77431.1 - 0.67 8.8 2.8 0.86 8.5 2.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4446 PF14584.6 EFA77431.1 - 0.87 9.6 4.9 0.39 10.7 2.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF5096 PF17019.5 EFA77431.1 - 6.2 6.6 9.7 1.9 8.2 6.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5096) Peptidase_S8 PF00082.22 EFA77433.1 - 3e-42 144.9 4.5 5.1e-42 144.2 4.5 1.3 1 0 0 1 1 1 1 Subtilase family RRM_1 PF00076.22 EFA77433.1 - 6.9e-16 57.8 0.1 2.2e-08 33.8 0.1 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EFA77434.1 - 2.7e-27 95.8 4.8 4.1e-26 91.9 2.6 2.8 1 1 1 2 2 2 1 Protein kinase domain FNIP PF05725.12 EFA77434.1 - 3.7e-22 78.2 17.7 6e-13 48.7 1.8 3.9 3 0 0 3 3 3 2 FNIP Repeat DUF4734 PF15881.5 EFA77434.1 - 0.059 13.5 3.3 0.078 13.1 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) DUF5617 PF18493.1 EFA77435.1 - 0.003 17.6 5.1 0.039 14.0 1.8 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF5617) CLTH PF10607.9 EFA77435.1 - 2.6 7.9 11.2 1.1 9.1 6.6 2.9 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain SNRNP27 PF08648.12 EFA77436.1 - 2.4e-13 49.9 2.3 2.4e-13 49.9 2.3 2.3 2 1 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins Metallophos PF00149.28 EFA77437.1 - 1.4e-13 51.8 0.1 1.4e-13 51.8 0.1 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase SapB_1 PF05184.15 EFA77437.1 - 0.0004 20.3 0.1 0.0011 19.0 0.1 1.7 1 0 0 1 1 1 1 Saposin-like type B, region 1 Metallophos PF00149.28 EFA77438.1 - 4.4e-39 135.1 0.1 5.3e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFA77438.1 - 4.8e-05 23.7 0.7 0.00011 22.5 0.7 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 EFA77438.1 - 0.027 14.6 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain ERG4_ERG24 PF01222.17 EFA77439.1 - 2e-87 293.8 26.6 2.1e-63 214.6 11.9 2.3 1 1 1 2 2 2 2 Ergosterol biosynthesis ERG4/ERG24 family FNIP PF05725.12 EFA77439.1 - 0.0086 16.2 0.0 0.026 14.7 0.0 1.8 1 0 0 1 1 1 1 FNIP Repeat DUF4133 PF13571.6 EFA77439.1 - 0.35 11.2 2.5 0.92 9.9 0.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4133) DUF3106 PF11304.8 EFA77441.1 - 0.086 13.3 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) FNIP PF05725.12 EFA77443.1 - 2.2e-128 418.2 57.9 4.1e-17 62.1 1.5 9.1 2 1 5 11 11 11 10 FNIP Repeat Pkinase PF00069.25 EFA77443.1 - 1.6e-29 103.1 5.8 5.7e-29 101.3 5.8 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77443.1 - 5.2e-12 45.6 0.6 2.3e-09 36.9 0.6 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA77443.1 - 0.022 14.1 0.0 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 EFA77443.1 - 0.032 14.2 0.1 1.2 9.0 0.2 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Phage_glycop_gL PF11108.8 EFA77443.1 - 0.12 12.4 0.8 1.6 8.8 0.0 2.7 2 0 0 2 2 2 0 Viral glycoprotein L Ku_PK_bind PF08785.11 EFA77444.1 - 1.6e-39 134.7 2.0 2.9e-39 133.9 1.1 2.0 2 0 0 2 2 2 1 Ku C terminal domain like Ku_N PF03731.15 EFA77444.1 - 5.4e-24 85.2 3.8 5.4e-24 85.2 3.8 2.2 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 EFA77444.1 - 4.6e-19 68.9 0.3 1.5e-18 67.3 0.3 2.0 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 EFA77444.1 - 4e-11 43.4 0.8 4e-11 43.4 0.8 3.1 3 1 0 3 3 3 1 Ku70/Ku80 C-terminal arm VWA_2 PF13519.6 EFA77444.1 - 0.0073 16.9 0.0 0.034 14.8 0.0 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFA77444.1 - 0.0086 16.3 0.3 0.018 15.3 0.3 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Ydc2-catalyt PF09159.10 EFA77444.1 - 6.1 6.5 8.9 0.7 9.6 0.5 2.5 3 0 0 3 3 3 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Myotub-related PF06602.14 EFA77446.1 - 9.1e-89 297.8 0.5 9.1e-89 297.8 0.5 2.3 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain COR PF16095.5 EFA77446.1 - 1.3e-55 188.3 0.1 2.4e-55 187.4 0.1 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase_Tyr PF07714.17 EFA77446.1 - 1.9e-52 178.1 0.0 4.2e-52 177.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA77446.1 - 2.1e-41 142.0 0.0 4.5e-41 140.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Roc PF08477.13 EFA77446.1 - 1.6e-26 92.9 0.2 1e-24 87.0 0.1 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 EFA77446.1 - 4.6e-26 90.4 41.4 2.3e-06 27.3 4.3 6.1 5 0 0 5 5 5 5 Leucine rich repeat Ras PF00071.22 EFA77446.1 - 1.4e-13 50.8 1.1 2.3e-13 50.0 0.2 1.9 2 0 0 2 2 2 1 Ras family WD40 PF00400.32 EFA77446.1 - 1.9e-09 38.0 29.4 0.016 16.1 0.5 7.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Arf PF00025.21 EFA77446.1 - 2e-06 27.4 1.0 8.1e-06 25.4 1.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA77446.1 - 0.004 17.2 0.0 0.004 17.2 0.0 2.2 2 0 0 2 2 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFA77446.1 - 0.0059 16.9 0.0 2.3 8.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain ANAPC4_WD40 PF12894.7 EFA77446.1 - 0.0087 16.3 4.6 7.4 6.9 0.2 4.5 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TniB PF05621.11 EFA77446.1 - 0.015 14.8 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein RA PF00788.23 EFA77446.1 - 0.015 15.9 0.0 0.062 13.9 0.0 2.1 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain PduV-EutP PF10662.9 EFA77446.1 - 0.07 12.9 0.2 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation APH PF01636.23 EFA77446.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Rep_4 PF05797.11 EFA77447.1 - 0.034 13.3 0.3 0.036 13.2 0.3 1.1 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) RGS PF00615.19 EFA77448.1 - 0.0091 16.3 6.2 0.0091 16.3 6.2 2.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain Ank_2 PF12796.7 EFA77450.1 - 4.8e-17 62.3 12.6 2.6e-06 27.9 0.1 7.1 4 3 4 8 8 8 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA77450.1 - 3.4e-11 43.2 0.5 0.0002 21.6 0.0 6.3 4 2 4 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77450.1 - 9e-11 41.0 4.7 1.3 9.8 0.0 11.0 12 2 2 14 14 14 3 Ankyrin repeat Ank_4 PF13637.6 EFA77450.1 - 1.4e-08 35.1 5.3 0.085 13.5 0.0 7.4 5 4 4 9 9 9 3 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA77450.1 - 6e-07 29.3 18.8 0.00034 20.5 0.3 6.2 4 3 1 5 5 5 2 Domain of unknown function (DUF3447) T3SS_ATPase_C PF18269.1 EFA77450.1 - 0.054 13.4 0.0 7.5 6.5 0.0 3.2 3 0 0 3 3 3 0 T3SS EscN ATPase C-terminal domain Ku PF02735.16 EFA77451.1 - 2.2e-13 50.4 0.0 2.7e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain FNIP PF05725.12 EFA77452.1 - 2.3e-34 117.3 28.3 1.7e-14 53.7 0.7 5.4 5 1 1 6 6 6 3 FNIP Repeat Pkinase PF00069.25 EFA77452.1 - 6.2e-30 104.4 4.6 6.2e-30 104.4 4.6 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77452.1 - 8.2e-13 48.2 0.3 1.1e-08 34.8 0.2 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFA77452.1 - 0.0012 18.8 0.0 0.8 9.6 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFA77452.1 - 0.083 12.2 0.0 0.24 10.7 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Ank_2 PF12796.7 EFA77453.1 - 6e-24 84.4 1.6 5.3e-09 36.5 0.1 4.7 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77453.1 - 1e-20 73.8 6.0 0.00092 19.7 0.1 7.6 4 3 3 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77453.1 - 6.1e-20 71.0 1.0 0.00043 20.5 0.0 8.0 5 2 3 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77453.1 - 5e-13 48.0 3.8 6.6 7.6 0.0 9.6 9 1 1 10 10 10 1 Ankyrin repeat DUF5049 PF16468.5 EFA77453.1 - 0.021 14.7 0.7 22 5.0 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) ENTH PF01417.20 EFA77453.1 - 0.023 14.8 1.7 4.5 7.3 0.0 3.4 2 1 1 3 3 3 0 ENTH domain YqbF PF14553.6 EFA77453.1 - 0.24 11.3 1.3 6.9 6.6 0.1 3.4 3 1 1 4 4 4 0 YqbF, hypothetical protein domain Ank PF00023.30 EFA77453.1 - 0.29 11.7 2.6 1.8e+02 2.8 0.0 4.9 7 0 0 7 7 7 0 Ankyrin repeat RVT_1 PF00078.27 EFA77454.1 - 0.0021 17.6 1.1 0.01 15.4 0.0 2.4 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CK2S PF15011.6 EFA77454.1 - 0.03 14.2 0.7 0.073 12.9 0.4 1.8 2 0 0 2 2 2 0 Casein Kinase 2 substrate RNase_Zc3h12a_2 PF14626.6 EFA77454.1 - 0.088 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain DUF3138 PF11336.8 EFA77454.1 - 0.32 9.5 2.4 0.48 9.0 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Ank_2 PF12796.7 EFA77456.1 - 1.9e-09 38.0 0.0 0.00096 19.7 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA77456.1 - 3.5e-07 30.0 0.1 3 8.7 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFA77456.1 - 4.9e-07 30.2 1.6 0.16 12.6 0.1 4.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77456.1 - 1.2e-06 28.7 0.1 0.12 12.7 0.0 4.6 3 2 2 5 5 5 2 Ankyrin repeats (many copies) T3SS_LEE_assoc PF13327.6 EFA77457.1 - 0.12 12.3 0.0 0.14 12.2 0.0 1.0 1 0 0 1 1 1 0 Type III secretion system subunit Ank_2 PF12796.7 EFA77459.1 - 5.5e-16 58.9 4.6 1.2e-07 32.2 0.1 4.4 3 2 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA77459.1 - 3.5e-09 36.1 0.1 1.1 10.1 0.0 8.0 9 0 0 9 9 9 1 Ankyrin repeat Ank_5 PF13857.6 EFA77459.1 - 6e-09 36.0 0.2 7.5e-05 22.9 0.0 5.2 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA77459.1 - 9.6e-08 32.4 2.5 0.043 14.4 0.1 6.1 4 2 3 7 7 7 2 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA77459.1 - 1.6e-06 28.0 17.6 0.00025 21.0 0.8 5.4 5 1 0 5 5 5 2 Domain of unknown function (DUF3447) Acetyltransf_1 PF00583.25 EFA77459.1 - 5.1e-05 23.5 0.0 0.00013 22.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA77459.1 - 0.00015 21.7 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA77459.1 - 0.06 13.8 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFA77459.1 - 0.092 12.9 0.0 0.48 10.6 0.0 2.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Ku_PK_bind PF08785.11 EFA77460.1 - 8.5e-17 61.4 1.5 7.1e-16 58.4 1.5 2.0 1 1 0 1 1 1 1 Ku C terminal domain like FNIP PF05725.12 EFA77461.1 - 1e-60 201.7 25.3 7.8e-14 51.6 0.1 7.4 5 2 2 7 7 7 5 FNIP Repeat Pkinase PF00069.25 EFA77461.1 - 3e-25 89.1 0.5 4.1e-24 85.4 0.5 2.3 1 1 0 1 1 1 1 Protein kinase domain RT_RNaseH_2 PF17919.1 EFA77462.1 - 1.4e-28 98.8 0.0 2.9e-28 97.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EFA77462.1 - 1.6e-28 99.7 1.0 3.1e-28 98.8 0.4 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EFA77462.1 - 1.3e-25 89.7 0.0 4.5e-25 88.0 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EFA77462.1 - 1.6e-15 57.3 0.0 4.2e-15 56.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EFA77462.1 - 2.8e-15 56.1 0.5 1e-14 54.4 0.5 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain Asp_protease_2 PF13650.6 EFA77462.1 - 0.0013 19.3 0.2 0.0045 17.6 0.1 2.0 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 EFA77462.1 - 0.0018 18.3 1.6 0.0018 18.3 1.6 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 EFA77462.1 - 0.025 14.5 0.2 0.059 13.3 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle gag-asp_proteas PF13975.6 EFA77462.1 - 0.026 15.1 0.0 0.063 13.9 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Ank_2 PF12796.7 EFA77463.1 - 5.8e-12 46.0 3.1 0.0016 19.0 0.1 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77463.1 - 4.4e-10 39.9 0.2 0.15 12.7 0.0 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77463.1 - 8.7e-09 35.5 0.0 0.14 12.5 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77463.1 - 5.8e-08 32.4 0.1 5.2 8.0 0.0 5.4 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EFA77463.1 - 0.16 12.5 0.4 1.1e+02 3.5 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat Ank_2 PF12796.7 EFA77464.1 - 3.2e-23 82.1 13.3 9.9e-09 35.7 0.1 5.1 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77464.1 - 1.3e-19 70.2 5.6 0.00035 21.1 0.1 7.8 4 3 4 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77464.1 - 3.1e-17 62.4 4.1 0.00081 19.6 0.0 8.2 3 2 6 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77464.1 - 4.5e-17 60.4 2.7 2.4 9.0 0.0 10.3 10 1 1 11 11 11 5 Ankyrin repeat Hemagglutinin PF00509.18 EFA77464.1 - 0.1 11.0 4.5 1 7.6 0.2 2.2 2 0 0 2 2 2 0 Haemagglutinin Ank PF00023.30 EFA77464.1 - 0.14 12.7 0.2 3.3e+02 2.0 0.0 4.7 5 0 0 5 5 5 0 Ankyrin repeat Delta_lysin PF05372.11 EFA77464.1 - 6.9 6.1 6.3 0.69 9.3 1.0 2.1 2 0 0 2 2 2 0 Delta lysin family FNIP PF05725.12 EFA77465.1 - 4.1e-26 90.9 37.7 2.5e-12 46.7 0.2 6.8 6 1 1 7 7 7 5 FNIP Repeat Ank_2 PF12796.7 EFA77466.1 - 3.8e-30 104.3 13.2 8.9e-07 29.4 0.2 8.6 2 1 7 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77466.1 - 5.4e-28 97.0 16.3 3.8e-05 24.2 0.0 11.1 5 3 7 12 12 12 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77466.1 - 2.3e-26 91.5 7.4 0.032 14.6 0.0 12.8 7 2 8 15 15 15 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77466.1 - 2.8e-21 73.3 8.8 2.7 8.9 0.0 14.6 12 1 3 15 15 15 4 Ankyrin repeat Endotoxin_M PF00555.19 EFA77466.1 - 0.01 15.9 0.2 0.01 15.9 0.2 1.9 2 0 0 2 2 2 0 delta endotoxin Ank PF00023.30 EFA77466.1 - 0.012 16.0 0.2 2e+02 2.7 0.0 6.8 7 1 0 7 7 7 0 Ankyrin repeat HCNGP PF07818.13 EFA77467.1 - 6.7e-25 87.6 1.8 2.1e-24 86.0 1.8 1.8 1 0 0 1 1 1 1 HCNGP-like protein Lipoprotein_8 PF02030.15 EFA77469.1 - 0.013 14.2 0.0 0.017 13.8 0.0 1.1 1 0 0 1 1 1 0 Hypothetical lipoprotein (MG045 family) RRM_1 PF00076.22 EFA77474.1 - 8.5e-43 144.0 4.3 1.5e-17 63.1 0.1 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.27 EFA77474.1 - 8.3e-10 38.2 0.2 1e-08 34.7 0.1 2.3 2 0 0 2 2 2 1 SAP domain RRM_occluded PF16842.5 EFA77474.1 - 3.6e-05 23.5 0.5 4.1 7.3 0.1 4.5 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EFA77474.1 - 0.034 13.8 0.1 0.034 13.8 0.1 3.5 3 1 1 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ThiF PF00899.21 EFA77475.1 - 8.2e-30 103.9 0.0 1.2e-29 103.3 0.0 1.3 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EFA77475.1 - 0.023 14.9 0.0 0.064 13.5 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle Methyltransf_12 PF08242.12 EFA77475.1 - 0.06 14.1 0.2 0.23 12.2 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain Semialdhyde_dh PF01118.24 EFA77475.1 - 0.1 13.0 0.4 4.7 7.7 0.0 3.0 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain Folate_carrier PF01770.18 EFA77475.1 - 0.11 11.2 0.1 0.15 10.8 0.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier Ku_PK_bind PF08785.11 EFA77477.1 - 1.3e-26 93.1 4.0 1.8e-16 60.3 0.5 2.3 1 1 1 2 2 2 2 Ku C terminal domain like LIN52 PF10044.9 EFA77477.1 - 0.014 16.1 0.2 0.03 15.0 0.1 1.6 1 1 0 1 1 1 0 Retinal tissue protein Ydc2-catalyt PF09159.10 EFA77477.1 - 0.1 12.4 5.0 0.82 9.3 0.4 2.1 2 0 0 2 2 2 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 CHIP_TPR_N PF18391.1 EFA77477.1 - 0.24 12.2 6.0 74 4.2 6.0 2.4 1 1 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain FNIP PF05725.12 EFA77478.1 - 8.6e-54 179.5 26.8 5.8e-15 55.2 0.8 5.6 4 1 1 5 5 5 4 FNIP Repeat Pkinase PF00069.25 EFA77478.1 - 3.2e-29 102.1 9.5 3.7e-29 101.9 4.7 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77478.1 - 2.2e-11 43.6 0.3 2.8e-08 33.4 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA77478.1 - 0.0096 15.3 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFA77478.1 - 0.011 15.7 0.0 0.61 10.0 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kin17_mid PF10357.9 EFA77478.1 - 0.37 10.7 12.6 0.18 11.7 4.9 3.4 3 0 0 3 3 3 0 Domain of Kin17 curved DNA-binding protein Bunya_G2 PF03563.13 EFA77479.1 - 0.089 12.0 1.6 0.095 11.9 1.6 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 Serinc PF03348.15 EFA77480.1 - 1.1e-123 413.4 17.4 1.3e-123 413.2 17.4 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) PTase_Orf2 PF11468.8 EFA77480.1 - 0.089 12.2 0.7 0.87 8.9 0.3 2.1 2 0 0 2 2 2 0 Aromatic prenyltransferase Orf2 Pkinase PF00069.25 EFA77482.1 - 6.2e-29 101.2 6.0 4.3e-27 95.1 6.0 2.3 1 1 0 1 1 1 1 Protein kinase domain FNIP PF05725.12 EFA77482.1 - 3e-18 65.7 10.9 6.3e-09 35.9 0.6 3.7 3 1 0 3 3 3 2 FNIP Repeat Pkinase_Tyr PF07714.17 EFA77482.1 - 2e-11 43.7 0.4 1e-09 38.1 0.4 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA77482.1 - 0.0016 18.4 0.0 0.25 11.2 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFA77482.1 - 0.0081 15.5 0.0 0.046 13.0 0.0 2.1 1 1 0 1 1 1 1 Kinase-like DENN PF02141.21 EFA77483.1 - 1.1e-33 116.8 4.6 1.1e-33 116.8 4.6 2.8 4 0 0 4 4 4 1 DENN (AEX-3) domain LIM PF00412.22 EFA77483.1 - 5.7e-09 36.1 11.9 1.3e-08 35.0 7.4 2.7 2 0 0 2 2 2 1 LIM domain uDENN PF03456.18 EFA77483.1 - 5e-06 27.2 7.4 2.1e-05 25.1 0.1 4.2 3 1 0 3 3 3 1 uDENN domain SPA PF08616.10 EFA77483.1 - 0.0011 18.9 0.9 0.0032 17.4 0.2 2.1 2 0 0 2 2 2 1 Stabilization of polarity axis zf-RING_UBOX PF13445.6 EFA77483.1 - 0.018 15.1 0.9 0.058 13.4 0.9 1.9 1 0 0 1 1 1 0 RING-type zinc-finger DUF2175 PF09943.9 EFA77483.1 - 0.69 10.2 2.5 15 6.0 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Siva PF05458.12 EFA77484.1 - 0.00074 19.2 5.0 0.00074 19.2 5.0 1.7 2 0 0 2 2 2 1 Cd27 binding protein (Siva) Pput2613-deam PF14427.6 EFA77484.1 - 0.045 13.6 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Pput_2613-like deaminase zf-piccolo PF05715.13 EFA77484.1 - 10 6.4 14.6 5.2 7.3 9.4 2.8 2 1 1 3 3 3 0 Piccolo Zn-finger PapD_C PF02753.17 EFA77487.1 - 0.0062 16.9 0.4 0.0086 16.4 0.4 1.3 1 1 0 1 1 1 1 Pili assembly chaperone PapD, C-terminal domain TctC PF03401.14 EFA77487.1 - 0.028 13.5 0.0 0.028 13.5 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor DUF4859 PF16151.5 EFA77487.1 - 0.075 12.9 0.1 0.081 12.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4859) GST_C_6 PF17171.4 EFA77488.1 - 2.8e-15 55.8 0.0 5.9e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFA77488.1 - 1.3e-13 51.5 0.1 3.3e-13 50.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EFA77488.1 - 1.8e-09 37.5 0.0 3.5e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA77488.1 - 0.00014 22.0 0.0 0.00027 21.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EFA77488.1 - 0.00014 22.1 0.0 0.00025 21.4 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_3 PF13417.6 EFA77488.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Cas9_Topo PF17894.1 EFA77488.1 - 0.2 11.7 2.0 26 5.0 0.6 3.0 2 1 1 3 3 3 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 FNIP PF05725.12 EFA77489.1 - 4.6e-94 308.4 48.0 5.9e-16 58.3 0.4 10.7 11 0 0 11 11 11 8 FNIP Repeat Pkinase PF00069.25 EFA77489.1 - 3.2e-31 108.6 4.9 3.4e-30 105.3 4.9 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77489.1 - 2.8e-12 46.5 0.3 2.1e-10 40.3 0.5 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase AAA_lid_2 PF17863.1 EFA77489.1 - 4.7e-09 36.0 0.0 2e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 AAA lid domain APH PF01636.23 EFA77489.1 - 0.00014 21.9 0.1 0.3 11.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family AAA_3 PF07726.11 EFA77489.1 - 0.00044 20.1 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF1769 PF08588.10 EFA77489.1 - 0.0011 19.1 3.2 0.31 11.3 0.1 5.0 4 1 1 5 5 5 1 Protein of unknown function (DUF1769) Kinase-like PF14531.6 EFA77489.1 - 0.059 12.7 0.0 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 Kinase-like SGS PF05002.15 EFA77490.1 - 1.5e-26 92.3 1.1 1.5e-26 92.3 1.1 2.1 2 0 0 2 2 1 1 SGS domain CS PF04969.16 EFA77490.1 - 4.1e-15 56.6 0.4 6.8e-15 55.8 0.4 1.4 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 EFA77490.1 - 5.9e-15 54.1 0.3 0.0013 18.7 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA77490.1 - 4.1e-14 51.7 2.8 0.0009 19.0 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77490.1 - 2.4e-09 36.7 0.7 0.0056 16.3 0.0 3.3 1 1 2 3 3 3 3 TPR repeat ANAPC3 PF12895.7 EFA77490.1 - 9e-09 35.5 0.7 1.5e-08 34.8 0.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFA77490.1 - 2.3e-08 33.6 0.6 0.0037 17.4 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA77490.1 - 2.1e-05 24.5 1.2 0.006 16.9 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA77490.1 - 3.1e-05 24.4 0.0 0.025 15.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA77490.1 - 0.00023 21.6 0.0 0.24 11.9 0.0 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA77490.1 - 0.00036 20.5 0.0 0.064 13.3 0.0 2.5 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 EFA77490.1 - 0.00077 19.7 0.2 1.3 9.3 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA77490.1 - 0.0027 18.3 0.0 3.4 8.4 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA77490.1 - 0.0031 17.4 0.0 0.066 13.3 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 EFA77490.1 - 0.01 15.9 0.7 2.6 8.2 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 EFA77490.1 - 0.013 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA77490.1 - 0.016 15.8 0.0 30 5.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 EFA77490.1 - 0.024 14.5 0.1 9.2 6.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) RIG-I_C PF18119.1 EFA77490.1 - 0.024 14.6 0.1 0.056 13.5 0.1 1.7 1 1 0 1 1 1 0 RIG-I receptor C-terminal domain Mucin PF01456.17 EFA77490.1 - 1.5 8.8 19.9 2.8 7.9 19.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_L16 PF00252.18 EFA77491.1 - 4.3e-42 143.2 0.0 5.5e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e CN_hydrolase PF00795.22 EFA77492.1 - 3.9e-64 216.5 0.0 5e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RPS31 PF17067.5 EFA77492.1 - 0.039 14.1 2.9 0.095 12.9 2.9 1.6 1 0 0 1 1 1 0 Ribosomal protein S31e DUF4518 PF15008.6 EFA77495.1 - 0.089 12.0 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) DUF2540 PF10802.8 EFA77495.1 - 0.1 12.7 0.8 0.29 11.2 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) SAP PF02037.27 EFA77495.1 - 0.18 11.6 0.2 1.2 9.0 0.1 2.4 2 1 0 2 2 2 0 SAP domain DUF1189 PF06691.11 EFA77495.1 - 0.94 9.0 5.2 1.9 8.0 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) OHCU_decarbox PF09349.10 EFA77496.1 - 1.7e-37 129.3 0.0 3.1e-37 128.5 0.0 1.4 1 0 0 1 1 1 1 OHCU decarboxylase Amidohydro_1 PF01979.20 EFA77496.1 - 6.6e-26 91.4 0.0 8.6e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFA77496.1 - 3.7e-14 53.1 0.4 8.1e-11 42.1 0.0 2.5 2 1 0 2 2 2 2 Amidohydrolase family Vta1 PF04652.16 EFA77497.1 - 2.4e-40 137.9 0.3 2.4e-40 137.9 0.3 2.4 2 1 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EFA77497.1 - 3.6e-15 55.4 0.1 3.6e-15 55.4 0.1 1.7 2 0 0 2 2 2 1 Vta1 C-terminal domain TFIIA PF03153.13 EFA77497.1 - 0.0043 17.1 53.4 0.0043 17.1 53.4 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit FNIP PF05725.12 EFA77498.1 - 8.6e-56 185.9 40.6 6.1e-13 48.7 3.9 9.8 6 2 3 10 10 10 7 FNIP Repeat Pkinase PF00069.25 EFA77498.1 - 4e-26 92.0 3.4 1.2e-25 90.4 3.4 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77498.1 - 2.7e-09 36.7 0.1 1e-07 31.5 0.2 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA77498.1 - 9.7e-05 21.8 0.0 0.0012 18.2 0.0 2.1 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EFA77498.1 - 0.0042 16.6 0.2 0.01 15.4 0.2 1.7 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 EFA77498.1 - 0.0052 16.7 0.0 3.7 7.4 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family KHA PF11834.8 EFA77498.1 - 0.041 14.0 0.2 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel DFF-C PF09033.10 EFA77498.1 - 0.17 11.7 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain AJAP1_PANP_C PF15298.6 EFA77500.1 - 0.21 11.7 8.7 0.26 11.5 8.7 1.1 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Dicty_REP PF05086.12 EFA77500.1 - 1.2 7.0 7.9 1.2 7.0 7.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tir_receptor_C PF07489.11 EFA77500.1 - 1.9 8.4 8.2 2.1 8.3 8.2 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Kelch_6 PF13964.6 EFA77501.1 - 0.0002 21.5 4.3 0.17 12.2 0.1 4.5 4 2 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 EFA77501.1 - 0.0017 18.2 0.1 0.0063 16.5 0.1 2.0 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 EFA77501.1 - 0.081 12.5 3.8 28 4.4 0.4 3.8 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 EFA77501.1 - 1.8 8.7 4.5 1.2 9.2 0.3 2.7 3 0 0 3 3 3 0 Kelch motif zf-B_box PF00643.24 EFA77502.1 - 0.0088 16.2 15.1 0.017 15.2 15.1 1.5 1 0 0 1 1 1 1 B-box zinc finger zf-C3HC4 PF00097.25 EFA77502.1 - 0.26 11.2 11.2 0.61 10.0 11.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CBM_6 PF03422.15 EFA77503.1 - 0.018 15.3 0.3 0.025 14.9 0.3 1.3 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) DUF4690 PF15756.5 EFA77505.1 - 0.1 13.2 0.5 0.29 11.7 0.5 1.7 1 0 0 1 1 1 0 Small Novel Rich in Cartilage SPX PF03105.19 EFA77505.1 - 0.12 12.3 2.9 0.17 11.7 2.9 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 EFA77505.1 - 0.32 9.8 4.3 0.48 9.2 4.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EFA77505.1 - 1.5 7.3 6.6 2.1 6.8 6.6 1.1 1 0 0 1 1 1 0 Macoilin family DDE_1 PF03184.19 EFA77506.1 - 2.8e-10 40.1 1.2 9.9e-10 38.3 0.7 2.3 2 0 0 2 2 2 1 DDE superfamily endonuclease PKcGMP_CC PF16808.5 EFA77506.1 - 0.0042 16.9 5.5 0.54 10.2 0.2 3.1 2 1 1 3 3 3 2 Coiled-coil N-terminus of cGMP-dependent protein kinase FPP PF05911.11 EFA77506.1 - 0.11 10.6 44.1 0.26 9.4 44.1 1.5 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Tropomyosin_1 PF12718.7 EFA77506.1 - 0.25 11.5 33.5 0.014 15.6 24.1 3.1 2 1 1 3 3 3 0 Tropomyosin like XhlA PF10779.9 EFA77506.1 - 0.29 11.4 21.7 0.04 14.1 6.1 4.3 2 1 2 4 4 4 0 Haemolysin XhlA DUF1664 PF07889.12 EFA77506.1 - 1.3 9.0 13.7 4.9 7.2 8.9 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) HrpB7 PF09486.10 EFA77506.1 - 1.8 8.9 5.2 14 6.0 4.0 2.3 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Prefoldin_2 PF01920.20 EFA77506.1 - 3.3 7.7 33.1 0.22 11.5 6.0 5.1 3 1 2 5 5 5 0 Prefoldin subunit COG2 PF06148.11 EFA77506.1 - 4.6 7.3 16.5 2.1 8.4 9.2 2.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 SPX PF03105.19 EFA77510.1 - 0.033 14.1 1.8 0.05 13.5 1.8 1.2 1 0 0 1 1 1 0 SPX domain UFC1 PF08694.11 EFA77510.1 - 0.067 12.8 0.0 0.55 9.9 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 Apt1 PF10351.9 EFA77510.1 - 0.31 9.8 4.9 0.48 9.2 4.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mucin PF01456.17 EFA77511.1 - 0.033 14.2 14.0 0.05 13.6 14.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Agenet PF05641.12 EFA77511.1 - 0.06 13.8 0.3 0.46 11.0 0.1 2.1 2 0 0 2 2 2 0 Agenet domain FSA_C PF10479.9 EFA77511.1 - 7.3 4.6 8.2 12 3.9 8.2 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 EFA77511.1 - 8.5 4.4 15.0 10 4.2 15.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MIF4G PF02854.19 EFA77512.1 - 6.3e-20 71.7 44.9 9.2e-17 61.4 9.8 4.5 5 0 0 5 5 5 3 MIF4G domain Raftlin PF15250.6 EFA77515.1 - 1.1 7.9 13.6 1.2 7.8 13.6 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 EFA77515.1 - 1.7 7.3 15.8 2.1 7.0 15.8 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EFA77515.1 - 1.9 6.9 24.6 2.2 6.7 24.6 1.0 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 EFA77515.1 - 4.7 6.3 12.2 5.8 6.0 12.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Hydantoinase_B PF02538.14 EFA77516.1 - 3.1e-216 718.8 0.3 5.8e-216 717.9 0.1 1.5 2 0 0 2 2 2 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EFA77516.1 - 5.3e-99 331.1 0.0 9.5e-99 330.3 0.0 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFA77516.1 - 7.4e-51 172.4 0.5 4.1e-49 166.7 0.0 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region FlaA PF04620.12 EFA77516.1 - 0.13 11.9 0.1 0.25 11.0 0.1 1.3 1 0 0 1 1 1 0 Flagellar filament outer layer protein Flaa LIM PF00412.22 EFA77517.1 - 1.7e-60 201.1 56.4 3.9e-15 55.8 2.0 5.2 5 0 0 5 5 5 5 LIM domain RNA_pol_3_Rpc31 PF11705.8 EFA77517.1 - 1.5 9.0 12.7 2.3 8.4 12.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 zf-MYND PF01753.18 EFA77517.1 - 2.4 8.3 0.0 2.4 8.3 0.0 7.1 5 1 1 6 6 6 0 MYND finger FNIP PF05725.12 EFA77518.1 - 1.1e-41 140.7 26.5 4.2e-14 52.4 0.3 7.0 3 1 1 6 6 6 4 FNIP Repeat Pkinase PF00069.25 EFA77518.1 - 6e-31 107.8 7.2 1.9e-29 102.8 7.2 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77518.1 - 2.6e-13 49.9 1.1 2.9e-10 39.9 1.2 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFA77518.1 - 0.15 11.9 0.1 2.8 7.8 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family GFA PF04828.14 EFA77520.1 - 7.8e-05 22.9 0.6 9.5e-05 22.7 0.6 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme HEPN_STY4199 PF18729.1 EFA77520.1 - 0.014 14.6 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 STY4199-like HEPN TPR_17 PF13431.6 EFA77521.1 - 1.1e-06 28.6 0.2 0.0011 19.2 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77521.1 - 0.14 11.8 0.2 6 6.6 0.0 2.4 2 0 0 2 2 2 0 TPR repeat Beta_helix PF13229.6 EFA77522.1 - 6.4e-05 22.9 51.7 0.00071 19.5 21.2 2.9 1 1 2 3 3 3 3 Right handed beta helix region MtrG PF04210.13 EFA77522.1 - 0.024 14.5 0.2 0.024 14.5 0.2 1.9 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G NosD PF05048.13 EFA77522.1 - 4.9 6.3 40.0 6 6.1 10.1 2.7 1 1 1 2 2 2 0 Periplasmic copper-binding protein (NosD) DUF436 PF04260.12 EFA77523.1 - 0.06 13.0 0.1 0.072 12.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF436) Pro-kuma_activ PF09286.11 EFA77524.1 - 1.7e-34 119.1 0.0 3.5e-34 118.1 0.0 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFA77524.1 - 0.00033 20.0 1.0 0.0018 17.6 1.0 2.0 1 1 0 1 1 1 1 Subtilase family DUF3301 PF11743.8 EFA77525.1 - 0.069 12.8 0.2 0.2 11.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) A_deaminase PF00962.22 EFA77527.1 - 2.3e-78 263.8 0.0 1.1e-65 222.1 0.0 2.7 2 1 1 3 3 3 2 Adenosine/AMP deaminase PQ-loop PF04193.14 EFA77529.1 - 1.4e-18 66.4 17.8 5e-17 61.4 1.9 3.3 2 1 1 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 EFA77529.1 - 4.9e-06 27.4 8.4 0.0012 19.7 2.8 2.2 1 1 1 2 2 2 2 ER lumen protein retaining receptor SdrD_B PF17210.3 EFA77530.1 - 1.9e-22 79.6 84.6 1.1e-09 38.5 1.8 9.4 7 2 3 10 10 10 6 SdrD B-like domain SpaA PF17802.1 EFA77530.1 - 6.3e-05 23.2 7.3 0.00042 20.6 1.8 8.8 7 1 0 7 7 7 3 Prealbumin-like fold domain FOLN PF09289.10 EFA77530.1 - 0.0096 16.1 1.6 0.0096 16.1 1.6 8.0 8 0 0 8 8 8 2 Follistatin/Osteonectin-like EGF domain TILa PF12714.7 EFA77530.1 - 3.4 7.7 50.6 0.03 14.3 0.8 7.0 6 1 0 7 7 7 0 TILa domain Dopey_N PF04118.14 EFA77531.1 - 4.5e-59 200.1 16.6 3.3e-58 197.2 2.6 3.9 4 1 1 5 5 5 2 Dopey, N-terminal fn3 PF00041.21 EFA77533.1 - 3.8e-14 52.8 18.3 6.1e-05 23.3 0.3 8.7 7 1 0 7 7 7 3 Fibronectin type III domain DUF2369 PF10179.9 EFA77533.1 - 5.6e-06 26.7 8.3 0.24 11.8 0.0 6.2 6 0 0 6 6 6 1 Uncharacterised conserved protein (DUF2369) EGF_2 PF07974.13 EFA77533.1 - 0.0057 17.0 6.6 0.021 15.2 6.6 2.0 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 EFA77533.1 - 0.057 13.6 5.5 0.18 12.0 5.5 1.9 1 0 0 1 1 1 0 Laminin EGF domain DUF5305 PF17231.2 EFA77533.1 - 0.059 12.8 0.1 0.059 12.8 0.1 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5305) SKG6 PF08693.10 EFA77533.1 - 0.11 11.9 3.0 0.34 10.4 3.0 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pre-SET PF05033.16 EFA77533.1 - 0.14 12.8 2.3 0.42 11.3 0.5 2.9 2 0 0 2 2 2 0 Pre-SET motif hEGF PF12661.7 EFA77533.1 - 0.36 11.5 2.2 3.4 8.4 2.2 2.9 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 EFA77533.1 - 1.2 9.5 7.0 0.49 10.7 2.9 2.6 2 0 0 2 2 2 0 EGF-like domain HMG_box PF00505.19 EFA77534.1 - 1.3e-11 44.7 2.0 1.6e-11 44.5 2.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFA77534.1 - 6.6e-05 23.4 0.8 9.3e-05 22.9 0.7 1.4 1 1 0 1 1 1 1 HMG-box domain Arm PF00514.23 EFA77535.1 - 1.2e-47 158.5 12.2 1.1e-07 31.7 0.0 8.9 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 EFA77535.1 - 0.00014 21.8 0.5 0.15 12.0 0.1 3.6 2 2 1 4 4 4 2 Domain of unknown function (DUF3361) HEAT_EZ PF13513.6 EFA77535.1 - 0.00079 19.9 4.4 0.9 10.1 0.1 4.6 4 2 1 5 5 5 2 HEAT-like repeat HEAT PF02985.22 EFA77535.1 - 0.00091 19.3 6.6 0.97 9.9 0.0 5.4 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EFA77535.1 - 0.0022 18.3 0.0 1.8 9.0 0.0 3.4 2 2 2 4 4 4 2 HEAT repeats Atx10homo_assoc PF09759.9 EFA77535.1 - 0.0044 17.0 1.2 0.23 11.5 0.0 2.8 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain MORN PF02493.20 EFA77536.1 - 3.7e-36 120.9 47.4 5.1e-07 29.2 2.1 11.7 11 1 1 12 12 12 9 MORN repeat BUD22 PF09073.10 EFA77537.1 - 2.1 7.6 48.7 0.037 13.4 10.4 3.2 3 0 0 3 3 3 0 BUD22 DUF3641 PF12345.8 EFA77538.1 - 0.018 15.0 0.8 0.029 14.4 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) UPF0184 PF03670.13 EFA77539.1 - 0.0039 17.6 0.0 0.0056 17.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) HNF-1_N PF04814.13 EFA77539.1 - 0.043 14.4 0.9 0.047 14.3 0.9 1.1 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Dicty_REP PF05086.12 EFA77539.1 - 0.17 9.8 1.2 0.17 9.9 1.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 EFA77539.1 - 0.18 10.0 7.0 0.22 9.7 7.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 EFA77539.1 - 0.52 10.3 11.2 0.75 9.8 11.2 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DDE_Tnp_4 PF13359.6 EFA77540.1 - 9e-14 51.4 0.0 1.6e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Ku PF02735.16 EFA77540.1 - 3.4e-06 26.9 0.1 6e-06 26.1 0.1 1.5 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain HTH_Tnp_4 PF13613.6 EFA77540.1 - 1.8e-05 24.4 0.2 3.8e-05 23.3 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA77540.1 - 0.00013 21.7 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain DUF5454 PF17535.2 EFA77542.1 - 0.074 12.4 0.0 0.077 12.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5454) Ku PF02735.16 EFA77543.1 - 2.1e-07 30.9 0.1 3.5e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 EFA77543.1 - 5e-06 26.7 0.2 1.6e-05 25.1 0.1 1.9 2 0 0 2 2 2 1 Ku C terminal domain like Ku_C PF03730.14 EFA77543.1 - 0.00021 21.9 0.5 0.0013 19.4 0.2 2.2 2 1 0 2 2 2 1 Ku70/Ku80 C-terminal arm Cytochrome_B PF00033.19 EFA77543.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Cytochrome b/b6/petB FNIP PF05725.12 EFA77544.1 - 2e-64 213.5 24.4 5.1e-16 58.6 0.5 6.7 5 1 1 6 6 6 5 FNIP Repeat Pkinase PF00069.25 EFA77544.1 - 2.6e-28 99.1 2.5 2.6e-28 99.1 2.5 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77544.1 - 1.6e-09 37.4 0.1 1.7e-07 30.8 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA77544.1 - 0.0011 18.9 0.1 0.25 11.2 0.3 2.1 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFA77544.1 - 0.018 14.4 0.0 0.092 12.0 0.0 2.0 2 0 0 2 2 2 0 Kinase-like adh_short PF00106.25 EFA77545.1 - 4.2e-15 55.7 0.8 6.4e-14 51.9 0.0 2.6 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA77545.1 - 1.7e-07 31.0 0.1 1.4e-05 24.8 0.0 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA77545.1 - 0.026 14.4 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 KR domain DEAD PF00270.29 EFA77547.1 - 4.8e-24 85.1 0.5 7.8e-23 81.1 0.1 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA77547.1 - 3.5e-06 27.3 2.6 5.3e-06 26.7 0.4 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EFA77547.1 - 0.046 13.0 0.0 0.046 13.0 0.0 3.1 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit Pex14_N PF04695.13 EFA77547.1 - 0.13 12.9 7.1 4.5 7.9 3.2 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3333 PF11812.8 EFA77547.1 - 1.3 9.2 4.6 0.65 10.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) VWA_2 PF13519.6 EFA77548.1 - 0.00032 21.3 8.1 0.00077 20.1 0.0 4.0 2 2 0 2 2 2 1 von Willebrand factor type A domain Sec23_trunk PF04811.15 EFA77548.1 - 0.00041 20.0 0.1 0.00041 20.0 0.1 3.1 3 1 0 3 3 3 1 Sec23/Sec24 trunk domain TFIIA PF03153.13 EFA77548.1 - 0.00061 19.9 47.1 0.005 16.9 16.8 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Sec23_BS PF08033.12 EFA77548.1 - 0.0021 18.7 0.1 0.0021 18.7 0.1 2.7 2 1 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain VWA_CoxE PF05762.14 EFA77548.1 - 0.0037 16.7 0.3 1.5 8.1 0.0 3.3 3 0 0 3 3 3 1 VWA domain containing CoxE-like protein zf-Sec23_Sec24 PF04810.15 EFA77548.1 - 0.028 14.4 0.2 0.095 12.8 0.2 2.0 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger BChl_A PF02327.17 EFA77548.1 - 0.049 12.4 0.0 0.12 11.2 0.0 1.6 1 0 0 1 1 1 0 Bacteriochlorophyll A protein FNIP PF05725.12 EFA77549.1 - 2.8e-70 232.2 34.9 4.8e-16 58.7 0.1 5.2 2 1 5 7 7 7 6 FNIP Repeat Pkinase PF00069.25 EFA77549.1 - 7.8e-33 114.0 5.9 5e-32 111.3 1.8 2.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77549.1 - 6.6e-15 55.1 0.1 9e-12 44.8 0.2 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA77549.1 - 0.00024 20.5 0.0 0.0058 16.0 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFA77549.1 - 0.028 14.3 0.0 4.7 7.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1533 PF07550.11 EFA77549.1 - 0.06 13.2 2.4 0.13 12.1 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) Methyltransf_11 PF08241.12 EFA77550.1 - 4.5e-05 24.0 0.0 0.00011 22.8 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA77550.1 - 9.4e-05 23.1 0.0 0.00015 22.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA77550.1 - 9.7e-05 22.3 0.0 9.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77550.1 - 0.12 13.1 0.0 0.25 12.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain DNA_pol_phi PF04931.13 EFA77551.1 - 3e-98 329.9 48.9 8.4e-68 229.2 7.3 3.9 3 1 1 4 4 4 2 DNA polymerase phi SDA1 PF05285.12 EFA77551.1 - 0.00097 18.7 19.4 0.00097 18.7 19.4 3.5 4 0 0 4 4 4 1 SDA1 ThiF PF00899.21 EFA77552.1 - 2.7e-59 200.5 0.1 3.9e-59 200.0 0.1 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EFA77552.1 - 4.8e-09 36.7 0.0 9.3e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.20 EFA77552.1 - 0.0053 16.8 0.9 0.02 15.0 0.1 2.2 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EFA77552.1 - 0.026 14.1 0.3 0.043 13.4 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EFA77552.1 - 0.11 12.4 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFA77552.1 - 0.24 11.7 1.0 0.91 9.8 1.0 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EFA77552.1 - 0.27 10.8 2.9 0.49 9.9 2.9 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFA77552.1 - 0.41 9.8 1.9 0.6 9.3 1.9 1.2 1 0 0 1 1 1 0 FAD binding domain HD PF01966.22 EFA77553.1 - 1.5e-09 38.1 0.1 8.7e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 HD domain HDOD PF08668.12 EFA77553.1 - 0.014 14.9 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 HDOD domain Ras PF00071.22 EFA77554.1 - 1.3e-64 216.6 0.4 1.6e-64 216.4 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA77554.1 - 2.2e-36 124.7 0.3 3.8e-36 123.9 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA77554.1 - 7.9e-16 58.0 0.0 9.5e-16 57.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA77554.1 - 2.5e-06 27.0 0.0 3.2e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA77554.1 - 7e-06 26.0 0.4 0.096 12.6 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFA77554.1 - 1.5e-05 24.6 0.3 3.6e-05 23.4 0.2 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA77554.1 - 3.5e-05 23.9 0.0 0.00018 21.6 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA77554.1 - 0.001 18.5 0.1 0.0015 18.0 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 EFA77554.1 - 0.025 15.0 0.0 0.49 10.8 0.0 2.1 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFA77554.1 - 0.039 13.7 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA77554.1 - 0.06 13.6 0.0 0.11 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA77554.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EFA77554.1 - 0.077 12.7 0.2 0.39 10.5 0.2 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 EFA77554.1 - 0.093 12.7 0.0 0.11 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFA77554.1 - 0.094 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFA77554.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EFA77554.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain PNISR PF15996.5 EFA77555.1 - 1 9.6 18.8 1.5 9.1 18.8 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR UPF0239 PF06783.11 EFA77556.1 - 0.36 11.0 4.2 0.56 10.4 4.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) TPR_2 PF07719.17 EFA77557.1 - 2.4e-19 67.8 18.0 0.0099 15.9 0.0 10.9 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFA77557.1 - 1.4e-17 63.9 1.4 0.00058 20.3 0.0 7.4 5 2 1 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFA77557.1 - 2e-17 63.2 9.0 0.0068 16.7 0.1 7.6 3 1 3 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFA77557.1 - 3.1e-13 48.7 3.9 0.12 12.5 0.0 7.9 8 1 0 8 8 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFA77557.1 - 9.5e-13 47.4 16.9 0.83 9.6 0.0 10.1 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFA77557.1 - 1.3e-12 47.4 0.0 0.0067 17.1 0.0 6.7 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA77557.1 - 1.5e-12 46.7 20.4 0.11 12.8 0.0 11.5 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFA77557.1 - 4e-12 46.6 0.2 0.00054 20.6 0.0 6.0 3 2 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77557.1 - 4.5e-11 42.2 3.7 0.00032 20.3 0.0 5.9 6 1 1 7 7 7 3 TPR repeat TPR_17 PF13431.6 EFA77557.1 - 4.7e-11 42.3 14.8 0.024 15.0 0.1 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA77557.1 - 1.3e-05 25.4 13.3 0.69 10.2 2.2 5.0 2 1 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFA77557.1 - 0.0017 18.8 6.9 0.78 10.5 0.0 5.6 6 1 0 6 6 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFA77557.1 - 0.0029 17.4 16.2 7.5 6.6 0.0 8.1 9 0 0 9 9 8 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA77557.1 - 0.005 16.9 0.3 1.4 9.0 0.1 3.6 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 EFA77557.1 - 0.039 14.1 0.0 1.2 9.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 EFA77557.1 - 0.05 12.5 0.0 0.05 12.5 0.0 3.9 3 1 1 4 4 2 0 NMDA receptor-regulated protein 1 Auxin_canalis PF05703.11 EFA77557.1 - 6.6 6.6 11.0 15 5.5 11.0 1.6 1 0 0 1 1 1 0 Auxin canalisation Pkinase PF00069.25 EFA77558.1 - 9e-17 61.3 0.1 9e-17 61.3 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_C PF00433.24 EFA77558.1 - 1.2e-06 29.2 0.1 3.8e-06 27.5 0.1 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase_Tyr PF07714.17 EFA77558.1 - 4.1e-06 26.3 0.6 5.9e-06 25.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Tantalus PF15386.6 EFA77558.1 - 0.054 13.6 3.7 2 8.6 0.1 3.4 3 0 0 3 3 3 0 Drosophila Tantalus-like UPF0669 PF17065.5 EFA77561.1 - 0.054 13.2 0.2 0.45 10.3 0.0 2.0 1 1 1 2 2 2 0 Putative cytokine, C6ORF120 DUF962 PF06127.11 EFA77561.1 - 0.53 10.4 2.9 1.1 9.4 2.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF962) RTP1_C1 PF10363.9 EFA77562.1 - 4.6e-31 107.3 1.9 2.5e-30 104.9 0.1 3.2 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EFA77562.1 - 1.2e-09 37.7 2.6 1.3e-09 37.6 0.6 2.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 Telomere_reg-2 PF10193.9 EFA77562.1 - 0.0083 16.6 2.0 0.34 11.4 0.0 3.5 2 0 0 2 2 2 1 Telomere length regulation protein RhoGAP PF00620.27 EFA77562.1 - 0.032 14.1 1.7 0.059 13.2 0.1 2.2 2 0 0 2 2 2 0 RhoGAP domain ABC2_membrane PF01061.24 EFA77563.1 - 9.4e-76 253.9 61.2 2.3e-43 148.1 21.2 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EFA77563.1 - 1.2e-35 123.0 0.1 4.3e-17 62.9 0.0 2.7 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EFA77563.1 - 5.7e-27 93.5 7.1 4.1e-20 71.5 0.0 3.7 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EFA77563.1 - 2.1e-10 41.1 0.1 5.2e-10 39.8 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EFA77563.1 - 6.1e-07 29.5 0.2 5.9e-05 23.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EFA77563.1 - 1.2e-05 25.3 0.0 0.05 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA77563.1 - 1.3e-05 24.8 0.6 0.007 16.1 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 EFA77563.1 - 5.8e-05 22.4 43.0 0.00054 19.2 22.6 3.6 4 1 0 4 4 3 2 ABC-2 family transporter protein AAA_22 PF13401.6 EFA77563.1 - 0.0003 21.1 0.0 0.51 10.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA77563.1 - 0.0017 18.8 0.0 0.34 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EFA77563.1 - 0.003 17.2 0.1 0.043 13.4 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA77563.1 - 0.0049 17.4 0.1 0.74 10.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.23 EFA77563.1 - 0.014 15.5 0.0 4.5 7.4 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EFA77563.1 - 0.016 15.3 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFA77563.1 - 0.024 14.4 0.2 3.2 7.4 0.3 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFA77563.1 - 0.045 13.3 0.6 0.42 10.2 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 EFA77563.1 - 0.069 13.1 0.0 3.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA PF00004.29 EFA77563.1 - 0.069 13.6 0.2 8.6 6.8 0.1 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EFA77563.1 - 0.14 11.4 0.1 5.8 6.1 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.12 EFA77563.1 - 0.3 11.0 0.7 11 6.0 0.4 2.4 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 EFA77563.1 - 3.4 8.1 5.8 1.3 9.5 0.1 3.1 4 0 0 4 4 3 0 AAA domain RhoGEF PF00621.20 EFA77564.1 - 1.2e-48 165.8 10.5 2.8e-48 164.6 8.9 2.5 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EFA77564.1 - 2.5e-26 92.2 7.9 3.4e-16 59.7 2.0 4.9 3 1 0 3 3 3 3 PH domain ArfGap PF01412.18 EFA77564.1 - 4.8e-25 87.9 0.0 3.3e-24 85.2 0.0 2.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CH PF00307.31 EFA77564.1 - 1.1e-17 64.2 2.1 1.8e-17 63.5 0.5 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain PH_11 PF15413.6 EFA77564.1 - 8e-05 23.0 9.5 0.0002 21.7 0.2 4.0 3 1 0 3 3 3 1 Pleckstrin homology domain CAMSAP_CH PF11971.8 EFA77564.1 - 0.00015 21.5 0.1 0.00048 19.9 0.1 1.9 1 0 0 1 1 1 1 CAMSAP CH domain PH_9 PF15410.6 EFA77564.1 - 0.023 15.0 6.2 0.081 13.3 0.2 3.5 2 1 0 3 3 3 0 Pleckstrin homology domain PH_6 PF15406.6 EFA77564.1 - 0.034 14.4 0.5 0.15 12.4 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain CH_2 PF06294.11 EFA77564.1 - 0.84 9.8 3.6 0.81 9.8 0.0 2.9 3 0 0 3 3 3 0 CH-like domain in sperm protein IQ PF00612.27 EFA77564.1 - 0.97 9.4 7.7 0.083 12.7 2.3 2.1 2 0 0 2 2 2 0 IQ calmodulin-binding motif Ank_3 PF13606.6 EFA77565.1 - 0.013 16.0 0.2 30 5.6 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeat Ank_2 PF12796.7 EFA77565.1 - 0.022 15.3 0.1 0.095 13.3 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) TPR_2 PF07719.17 EFA77566.1 - 0.023 14.8 0.1 0.18 12.0 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat C1q PF00386.21 EFA77566.1 - 0.027 14.7 0.6 0.027 14.7 0.6 1.9 2 0 0 2 2 2 0 C1q domain Peptidase_S21 PF00716.17 EFA77566.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Assemblin (Peptidase family S21) Copper-bind PF00127.20 EFA77567.1 - 1.5 9.3 5.8 0.36 11.3 0.3 2.5 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family Sec1 PF00995.23 EFA77569.1 - 1.2e-63 216.3 0.0 5.8e-38 131.5 0.1 2.1 1 1 1 2 2 2 2 Sec1 family Pkinase_Tyr PF07714.17 EFA77570.1 - 1.2e-46 159.2 0.0 2e-46 158.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA77570.1 - 8.1e-40 136.8 0.0 1.4e-38 132.8 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain RasGEF PF00617.19 EFA77570.1 - 6.6e-37 127.4 0.1 2.2e-36 125.7 0.1 2.0 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.29 EFA77570.1 - 1.7e-23 82.5 0.0 9.8e-13 48.0 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain GRAM PF02893.20 EFA77570.1 - 2.3e-12 46.8 2.5 4.5e-12 45.9 1.7 2.0 2 0 0 2 2 2 1 GRAM domain RasGEF_N PF00618.20 EFA77570.1 - 4.3e-12 46.2 0.1 4.3e-12 46.2 0.1 2.9 3 0 0 3 3 2 1 RasGEF N-terminal motif DEP PF00610.21 EFA77570.1 - 5.6e-11 42.3 0.0 1.4e-09 37.9 0.0 2.5 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Roc PF08477.13 EFA77570.1 - 2.9e-09 37.2 0.2 8.1e-09 35.7 0.2 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 EFA77570.1 - 0.00029 20.7 0.0 0.00063 19.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain APH PF01636.23 EFA77570.1 - 0.0099 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ras PF00071.22 EFA77570.1 - 0.031 13.9 0.3 0.057 13.0 0.3 1.4 1 0 0 1 1 1 0 Ras family RHH_1 PF01402.21 EFA77570.1 - 0.13 12.2 0.2 0.81 9.7 0.7 2.1 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Ank_4 PF13637.6 EFA77571.1 - 1.2e-37 127.8 17.5 4.2e-05 24.0 0.0 11.9 9 3 3 12 12 12 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA77571.1 - 4.1e-36 123.4 13.3 1.3e-07 32.1 0.5 8.6 3 2 7 10 10 10 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA77571.1 - 4.9e-29 100.0 12.9 0.099 13.0 0.0 14.7 9 4 5 15 15 15 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77571.1 - 8e-23 78.1 19.1 4.5 8.2 0.0 16.6 19 0 0 19 19 19 5 Ankyrin repeat DUF249 PF03158.13 EFA77571.1 - 9.9e-05 22.1 17.6 0.016 14.9 0.5 5.8 3 1 3 6 6 6 3 Multigene family 530 protein DUF3447 PF11929.8 EFA77571.1 - 0.01 15.7 26.2 0.61 10.1 0.4 8.2 4 3 4 9 9 9 0 Domain of unknown function (DUF3447) Ank PF00023.30 EFA77571.1 - 0.023 15.2 0.8 3.6e+02 1.9 0.1 7.0 8 1 0 8 8 8 0 Ankyrin repeat AnkUBD PF18418.1 EFA77571.1 - 0.13 12.4 0.2 5.2 7.3 0.0 3.3 3 0 0 3 3 3 0 Ankyrin ubiquitin-binding domain Peptidase_C28 PF05408.11 EFA77571.1 - 0.18 11.5 2.1 1.3 8.7 0.1 2.7 3 0 0 3 3 3 0 Foot-and-mouth virus L-proteinase DUF4885 PF16226.5 EFA77572.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4885) TctC PF03401.14 EFA77572.1 - 0.16 11.0 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor Ku PF02735.16 EFA77573.1 - 1e-07 31.9 0.0 1e-07 31.9 0.0 1.0 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Pkinase PF00069.25 EFA77574.1 - 1.7e-30 106.3 8.5 1.7e-29 103.0 3.4 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77574.1 - 5.5e-13 48.8 0.2 1.4e-09 37.7 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase FNIP PF05725.12 EFA77574.1 - 6.6e-09 35.8 6.3 8.1e-07 29.1 1.9 3.8 1 1 1 2 2 2 2 FNIP Repeat APH PF01636.23 EFA77574.1 - 0.014 15.4 0.2 0.12 12.3 0.3 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family BTB_3 PF16017.5 EFA77574.1 - 0.081 13.0 1.2 1.4 9.1 0.2 3.1 3 1 0 3 3 3 0 BTB/POZ domain DUF3052 PF11253.8 EFA77574.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Mucin PF01456.17 EFA77575.1 - 0.049 13.6 11.4 0.057 13.4 11.4 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EFA77575.1 - 0.47 10.4 8.8 0.49 10.4 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Tir_receptor_C PF07489.11 EFA77575.1 - 3.6 7.5 7.4 3.8 7.4 7.4 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus FNIP PF05725.12 EFA77576.1 - 9.9e-22 76.8 18.2 4.6e-08 33.1 0.3 7.8 4 4 1 5 5 5 5 FNIP Repeat Cbl_N PF02262.16 EFA77577.1 - 0.37 10.8 4.3 1.4 9.0 4.3 2.0 1 0 0 1 1 1 0 CBL proto-oncogene N-terminal domain 1 MCU PF04678.13 EFA77577.1 - 1.7 8.7 5.4 9.3 6.3 0.8 2.8 2 0 0 2 2 2 0 Mitochondrial calcium uniporter 2OG-FeII_Oxy_3 PF13640.6 EFA77578.1 - 1e-09 39.1 0.1 1.7e-09 38.4 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFA77578.1 - 0.0014 17.8 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein 2OG-Fe_Oxy_2 PF10014.9 EFA77578.1 - 0.14 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe dioxygenase RGP PF03214.13 EFA77579.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Reversibly glycosylated polypeptide BRO1 PF03097.18 EFA77580.1 - 2.4e-105 352.6 10.9 2.4e-105 352.6 10.9 2.1 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EFA77580.1 - 1.1e-72 244.9 19.4 1.1e-72 244.9 19.4 2.6 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Biotin_carb_N PF00289.22 EFA77580.1 - 0.1 13.2 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 Biotin carboxylase, N-terminal domain SMN PF06003.12 EFA77580.1 - 0.17 11.1 5.0 0.36 10.0 5.0 1.6 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) KxDL PF10241.9 EFA77580.1 - 5.5 7.3 16.0 0.25 11.6 4.2 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein AAA PF00004.29 EFA77581.1 - 1.3e-36 125.9 0.0 2.8e-36 124.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA77581.1 - 2.4e-10 40.0 0.0 5.2e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EFA77581.1 - 1.1e-05 25.2 0.0 8.6e-05 22.3 0.0 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFA77581.1 - 1.4e-05 25.6 0.4 0.00059 20.3 0.4 2.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFA77581.1 - 2e-05 25.2 0.3 7.6e-05 23.3 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 EFA77581.1 - 3.6e-05 24.1 0.3 0.0055 17.0 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EFA77581.1 - 6.5e-05 23.1 0.0 0.00013 22.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFA77581.1 - 6.9e-05 22.9 0.0 0.0002 21.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFA77581.1 - 0.0002 21.5 0.0 0.0026 17.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFA77581.1 - 0.00054 20.0 0.1 0.0026 17.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFA77581.1 - 0.00065 19.0 0.4 0.0016 17.8 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_24 PF13479.6 EFA77581.1 - 0.001 18.8 0.1 0.0018 18.0 0.1 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EFA77581.1 - 0.0011 18.4 0.1 0.0024 17.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 EFA77581.1 - 0.0012 18.0 0.0 0.0025 16.9 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.17 EFA77581.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EFA77581.1 - 0.0016 18.8 0.1 0.015 15.6 0.1 2.3 1 1 0 1 1 1 1 RNA helicase Sigma54_activat PF00158.26 EFA77581.1 - 0.0053 16.5 0.0 0.015 15.0 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_17 PF13207.6 EFA77581.1 - 0.0054 17.2 0.4 0.02 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFA77581.1 - 0.014 15.3 0.7 0.054 13.4 0.2 2.0 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 EFA77581.1 - 0.019 14.9 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFA77581.1 - 0.021 15.1 0.1 0.054 13.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain Rad17 PF03215.15 EFA77581.1 - 0.033 14.1 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Methyltransf_3 PF01596.17 EFA77581.1 - 0.037 13.2 0.0 0.067 12.4 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase Zeta_toxin PF06414.12 EFA77581.1 - 0.044 13.1 0.2 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin SKI PF01202.22 EFA77581.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase PhoH PF02562.16 EFA77581.1 - 0.053 13.0 0.1 0.1 12.0 0.1 1.6 1 1 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 EFA77581.1 - 0.067 13.1 0.4 0.87 9.4 0.0 2.5 2 1 0 3 3 2 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EFA77581.1 - 0.091 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFA77581.1 - 0.091 12.3 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EFA77581.1 - 0.12 12.9 0.2 0.42 11.1 0.0 1.9 2 0 0 2 2 2 0 ABC transporter Kelch_6 PF13964.6 EFA77582.1 - 5.5e-16 58.2 3.7 2.5e-10 40.3 0.1 4.3 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA77582.1 - 0.00028 20.4 0.1 0.0035 16.9 0.0 2.7 3 0 0 3 3 3 1 Kelch motif Saccharop_dh_N PF04455.12 EFA77582.1 - 0.00098 19.5 0.4 0.003 17.9 0.4 1.8 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Kelch_2 PF07646.15 EFA77582.1 - 0.028 14.4 0.0 0.13 12.3 0.0 2.2 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.6 EFA77582.1 - 0.05 13.6 0.0 0.82 9.7 0.0 2.8 2 1 0 2 2 2 0 Galactose oxidase, central domain DUF3314 PF11771.8 EFA77584.1 - 0.087 13.0 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3314) DUF3949 PF13133.6 EFA77584.1 - 0.14 12.6 0.8 0.26 11.8 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3949) Thioredoxin_2 PF13098.6 EFA77585.1 - 0.0012 19.3 0.1 0.0015 18.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain ENTH PF01417.20 EFA77586.1 - 9e-16 58.1 8.7 8e-12 45.3 0.0 2.6 2 0 0 2 2 2 2 ENTH domain BLOC1_2 PF10046.9 EFA77587.1 - 2.4e-33 114.3 4.2 4.6e-33 113.4 4.2 1.5 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med9 PF07544.13 EFA77587.1 - 0.056 13.5 2.4 0.16 12.1 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 XhlA PF10779.9 EFA77587.1 - 0.27 11.5 1.5 0.75 10.0 1.5 1.7 1 0 0 1 1 1 0 Haemolysin XhlA HSBP1 PF06825.12 EFA77587.1 - 1.9 8.4 4.8 0.64 9.9 0.2 2.5 2 2 1 3 3 3 0 Heat shock factor binding protein 1 CCDC53 PF10152.9 EFA77587.1 - 4.4 7.7 9.9 0.47 10.9 2.2 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex MinE PF03776.14 EFA77588.1 - 1.1e-16 60.6 0.1 1.5e-16 60.2 0.1 1.2 1 0 0 1 1 1 1 Septum formation topological specificity factor MinE DUF3510 PF12022.8 EFA77588.1 - 0.0068 16.8 0.2 0.0098 16.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) DUF1957 PF09210.11 EFA77588.1 - 0.055 13.9 0.1 0.078 13.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) Chalcone_N PF18232.1 EFA77588.1 - 0.099 13.1 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Chalcone isomerase N-terminal domain Sacchrp_dh_C PF16653.5 EFA77589.1 - 6.6e-83 278.9 0.0 9.2e-83 278.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EFA77589.1 - 8.4e-21 74.6 0.0 2.1e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFA77589.1 - 0.0034 17.3 0.0 0.017 15.0 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding LRR_4 PF12799.7 EFA77589.1 - 3 8.4 6.8 9.8 6.8 2.7 2.8 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) HSP90 PF00183.18 EFA77590.1 - 3.9e-97 326.3 4.0 4e-93 313.1 1.3 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 EFA77590.1 - 1.5e-09 37.8 0.1 4.1e-09 36.4 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFA77590.1 - 3.9e-08 33.8 0.2 9.6e-08 32.5 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EGF_2 PF07974.13 EFA77592.1 - 1 9.8 10.5 2.3 8.6 10.5 1.6 1 0 0 1 1 1 0 EGF-like domain PIP5K PF01504.18 EFA77593.1 - 1.5e-71 240.9 12.6 1.5e-71 240.9 12.6 3.5 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase PH PF00169.29 EFA77593.1 - 2.5e-13 50.5 0.5 1.6e-12 47.9 0.2 2.7 2 0 0 2 2 2 1 PH domain Ribosomal_60s PF00428.19 EFA77593.1 - 0.044 14.4 1.1 0.33 11.6 0.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Utp14 PF04615.13 EFA77593.1 - 5.3 5.5 31.5 8 4.9 31.5 1.2 1 0 0 1 1 1 0 Utp14 protein Cystatin PF00031.21 EFA77594.1 - 0.015 15.6 0.3 0.071 13.4 0.4 1.9 2 0 0 2 2 2 0 Cystatin domain SAC3_GANP PF03399.16 EFA77595.1 - 3e-12 46.5 6.7 6.9e-07 28.9 0.6 2.3 1 1 1 2 2 2 2 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EFA77595.1 - 0.00015 21.7 1.6 0.00026 21.0 1.6 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Kelch_6 PF13964.6 EFA77596.1 - 4.1e-16 58.6 3.5 3.6e-10 39.8 0.1 4.4 4 1 1 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA77596.1 - 0.00029 20.9 11.6 0.00067 19.8 11.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA77596.1 - 0.0044 16.6 0.0 0.019 14.5 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Saccharop_dh_N PF04455.12 EFA77596.1 - 0.0044 17.4 1.2 0.01 16.2 0.3 2.1 2 0 0 2 2 2 1 LOR/SDH bifunctional enzyme conserved region zf-UBP PF02148.19 EFA77596.1 - 0.012 15.9 5.7 0.012 15.9 5.7 2.4 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Kelch_4 PF13418.6 EFA77596.1 - 0.026 14.6 0.0 1 9.4 0.0 3.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA77596.1 - 0.073 13.1 0.0 0.29 11.2 0.0 2.0 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 EFA77596.1 - 0.14 12.1 0.1 0.58 10.2 0.1 2.0 1 0 0 1 1 1 0 Kelch motif Zn_Tnp_IS91 PF14319.6 EFA77596.1 - 3.8 7.6 9.9 1.4 9.0 5.7 2.3 2 0 0 2 2 2 0 Transposase zinc-binding domain Peptidase_M1 PF01433.20 EFA77597.1 - 3.8e-74 248.9 0.8 6.8e-74 248.1 0.8 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFA77597.1 - 3.1e-66 224.1 0.0 1.2e-65 222.1 0.0 1.8 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFA77597.1 - 3.7e-51 174.0 1.6 6e-51 173.3 1.6 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF4351 PF14261.6 EFA77597.1 - 0.63 10.1 2.0 4.5 7.4 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4351) Kelch_6 PF13964.6 EFA77598.1 - 2.1e-15 56.4 7.6 7.5e-10 38.8 0.1 5.1 5 1 1 6 6 6 2 Kelch motif zf-B_box PF00643.24 EFA77598.1 - 0.00022 21.3 11.5 0.00054 20.1 11.5 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_2 PF07646.15 EFA77598.1 - 0.00028 20.8 0.1 0.03 14.3 0.0 3.1 2 0 0 2 2 2 1 Kelch motif Saccharop_dh_N PF04455.12 EFA77598.1 - 0.0019 18.6 0.3 0.0055 17.1 0.3 1.8 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Kelch_1 PF01344.25 EFA77598.1 - 0.0084 15.7 0.0 0.028 14.0 0.0 1.9 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 EFA77598.1 - 0.009 16.0 0.6 0.54 10.3 0.0 3.8 3 2 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA77598.1 - 0.01 15.8 2.5 0.026 14.5 0.0 2.6 2 0 0 2 2 2 0 Kelch motif Ntox28 PF15605.6 EFA77598.1 - 0.043 14.0 2.0 0.057 13.7 0.2 2.2 2 0 0 2 2 2 0 Bacterial toxin 28 RRM_7 PF16367.5 EFA77598.1 - 0.086 13.0 0.2 2.3 8.4 0.1 2.9 2 0 0 2 2 2 0 RNA recognition motif zf-UBP PF02148.19 EFA77598.1 - 0.27 11.6 9.8 0.044 14.1 5.1 2.2 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein ERAP1_C PF11838.8 EFA77599.1 - 2e-65 221.4 0.0 1.4e-64 218.6 0.0 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFA77599.1 - 1.7e-50 171.8 1.7 4e-50 170.6 1.7 1.7 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 EFA77599.1 - 2.5e-43 148.2 0.0 4.3e-23 82.0 0.0 2.5 1 1 1 2 2 2 2 Peptidase family M1 domain DUF4351 PF14261.6 EFA77599.1 - 0.18 11.9 2.0 4.3 7.5 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4351) DUF572 PF04502.13 EFA77600.1 - 4.6e-62 210.6 12.6 5.5e-62 210.3 12.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) CDH1_2_SANT_HL1 PF18375.1 EFA77600.1 - 0.068 13.8 0.3 0.068 13.8 0.3 1.9 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Mucin PF01456.17 EFA77600.1 - 3.8 7.5 17.7 6.1 6.8 17.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_L28 PF00830.19 EFA77601.1 - 3.7e-21 75.1 0.2 6.4e-21 74.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal L28 family 7tm_2 PF00002.24 EFA77602.1 - 1.6e-25 89.8 16.6 2.4e-25 89.3 16.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EFA77602.1 - 1.6e-17 63.6 24.3 2.8e-17 62.8 24.3 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 EFA77602.1 - 5.2e-10 38.9 18.4 1e-06 28.1 8.8 2.3 1 1 1 2 2 2 2 Frizzled/Smoothened family membrane region Ocular_alb PF02101.15 EFA77602.1 - 1.2e-06 27.7 12.5 1.9e-06 27.1 12.5 1.3 1 0 0 1 1 1 1 Ocular albinism type 1 protein DUF5325 PF17259.2 EFA77602.1 - 0.016 15.1 0.5 0.043 13.7 0.5 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5325) 7tm_1 PF00001.21 EFA77602.1 - 1.1 8.5 16.3 2.1 7.6 16.3 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) MMR_HSR1 PF01926.23 EFA77603.1 - 1.4e-05 25.2 0.5 1.4e-05 25.2 0.5 2.6 3 1 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA77603.1 - 0.00025 21.0 0.0 0.00064 19.7 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase Roc PF08477.13 EFA77603.1 - 0.0008 19.6 2.2 1.5 9.1 0.0 3.2 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase C1-set PF07654.15 EFA77603.1 - 0.021 15.2 0.2 0.071 13.5 0.2 1.9 1 0 0 1 1 1 0 Immunoglobulin C1-set domain Ras PF00071.22 EFA77603.1 - 0.022 14.4 0.1 7.7 6.1 0.0 2.6 2 0 0 2 2 2 0 Ras family AGH PF17558.2 EFA77603.1 - 0.025 14.8 0.9 0.063 13.4 0.9 1.7 1 0 0 1 1 1 0 Androgenic gland hormone FeoB_N PF02421.18 EFA77603.1 - 0.04 13.5 0.1 0.25 10.9 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_18 PF13238.6 EFA77603.1 - 0.074 13.6 1.3 0.27 11.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EFA77603.1 - 0.1 12.7 0.0 0.1 12.7 0.0 2.9 2 1 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 EFA77603.1 - 0.12 12.8 0.0 0.12 12.8 0.0 2.5 2 1 0 2 2 2 0 ABC transporter 2-oxoacid_dh PF00198.23 EFA77604.1 - 3e-81 272.3 0.0 2e-80 269.6 0.0 1.9 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFA77604.1 - 8.2e-20 70.4 0.0 1.5e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EFA77604.1 - 2.5e-12 46.9 0.0 9.9e-12 45.0 0.1 2.1 2 0 0 2 2 2 1 e3 binding domain HlyD_3 PF13437.6 EFA77604.1 - 0.0034 18.1 0.0 0.018 15.7 0.0 2.3 2 0 0 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 EFA77604.1 - 0.069 13.0 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like Ribosomal_60s PF00428.19 EFA77604.1 - 0.18 12.4 8.0 1.6 9.4 0.3 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3446 PF11928.8 EFA77604.1 - 0.24 11.7 15.8 2.5 8.5 4.4 3.4 3 0 0 3 3 3 0 Early growth response N-terminal domain DUF3123 PF11321.8 EFA77604.1 - 5.4 7.7 7.8 11 6.7 2.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) NAC PF01849.18 EFA77605.1 - 1.9e-19 69.4 0.1 4.2e-19 68.3 0.1 1.6 1 0 0 1 1 1 1 NAC domain cobW PF02492.19 EFA77606.1 - 9.7e-41 139.3 2.1 3.8e-40 137.3 1.0 2.3 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFA77606.1 - 0.00018 21.4 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EFA77606.1 - 0.062 13.2 0.1 0.15 12.0 0.1 1.6 2 0 0 2 2 2 0 RsgA GTPase Yip1 PF04893.17 EFA77607.1 - 3.4e-14 52.9 11.5 3.4e-14 52.9 11.5 1.4 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 EFA77607.1 - 0.17 11.4 13.0 1.9 8.0 13.0 2.2 1 1 0 1 1 1 0 YIF1 WD40 PF00400.32 EFA77608.1 - 6e-43 144.0 26.8 2.1e-08 34.7 0.9 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA77608.1 - 1.2e-20 73.6 9.3 6.1e-06 26.5 0.4 5.7 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA77608.1 - 8.5e-05 22.0 0.0 0.27 10.5 0.1 2.4 1 1 1 2 2 2 2 WD40-like domain VID27 PF08553.10 EFA77608.1 - 0.053 12.6 0.0 3.2 6.7 0.0 2.3 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Proteasome PF00227.26 EFA77609.1 - 3.8e-58 196.1 0.1 4.7e-58 195.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA77609.1 - 3.8e-15 55.2 0.1 8.9e-15 54.1 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature VWC PF00093.18 EFA77610.1 - 0.074 13.4 20.2 0.37 11.2 5.5 2.3 2 0 0 2 2 2 0 von Willebrand factor type C domain Kelch_6 PF13964.6 EFA77611.1 - 3.9e-18 65.0 8.1 5.8e-12 45.4 0.2 5.2 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EFA77611.1 - 0.0013 18.3 0.3 0.023 14.3 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Saccharop_dh_N PF04455.12 EFA77611.1 - 0.0025 18.2 0.3 0.0071 16.7 0.3 1.8 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Kelch_4 PF13418.6 EFA77611.1 - 0.0069 16.4 0.1 0.6 10.2 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA77611.1 - 0.013 15.5 0.8 0.062 13.3 0.1 2.7 3 0 0 3 3 3 0 Kelch motif Ntox28 PF15605.6 EFA77611.1 - 0.039 14.2 1.9 0.064 13.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial toxin 28 RRM_1 PF00076.22 EFA77611.1 - 0.057 13.3 0.5 1.7 8.5 0.1 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kelch_5 PF13854.6 EFA77611.1 - 0.12 12.4 0.2 0.53 10.3 0.2 2.1 1 0 0 1 1 1 0 Kelch motif NUC153 PF08159.12 EFA77612.1 - 1.2e-09 37.8 0.9 1.2e-09 37.8 0.9 4.8 5 0 0 5 5 5 2 NUC153 domain TPR_7 PF13176.6 EFA77613.1 - 3e-08 33.1 0.8 0.0004 20.2 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA77613.1 - 3.7e-07 29.8 3.8 0.0022 18.1 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA77613.1 - 4.4e-06 26.9 2.4 0.19 12.0 0.2 3.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFA77613.1 - 8.4e-06 25.5 0.1 0.086 12.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA77613.1 - 5.4e-05 22.8 10.5 0.0065 16.3 1.0 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA77613.1 - 6.6e-05 22.7 9.2 0.032 14.3 0.3 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA77613.1 - 0.0011 19.6 0.0 77 4.5 0.1 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA77613.1 - 0.011 15.1 0.0 0.028 13.8 0.0 1.6 1 1 0 1 1 1 0 MalT-like TPR region ANAPC5 PF12862.7 EFA77613.1 - 0.05 13.7 2.7 0.56 10.3 1.0 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_17 PF13431.6 EFA77613.1 - 9.3 6.9 6.7 11 6.7 0.1 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF3165 PF11364.8 EFA77614.1 - 0.048 14.0 0.4 0.048 14.0 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) PAP_assoc PF03828.19 EFA77614.1 - 0.068 13.4 0.1 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Cid1 family poly A polymerase ATP_bind_3 PF01171.20 EFA77615.1 - 1.5e-20 73.7 0.2 9.2e-12 45.1 0.0 4.0 2 1 2 4 4 4 3 PP-loop family DUF3560 PF12083.8 EFA77615.1 - 0.069 13.3 1.0 0.16 12.1 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3560) 4_1_CTD PF05902.13 EFA77615.1 - 0.19 11.8 3.4 0.35 10.9 0.1 2.8 3 0 0 3 3 3 0 4.1 protein C-terminal domain (CTD) LIN52 PF10044.9 EFA77615.1 - 1.9 9.2 0.0 1.9 9.2 0.0 2.9 3 0 0 3 3 3 0 Retinal tissue protein EMP24_GP25L PF01105.24 EFA77616.1 - 5.4e-50 169.9 0.7 6.4e-50 169.6 0.7 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ZipA_C PF04354.13 EFA77616.1 - 0.031 14.1 0.5 0.065 13.1 0.5 1.5 2 0 0 2 2 2 0 ZipA, C-terminal FtsZ-binding domain SdrD_B PF17210.3 EFA77616.1 - 0.036 14.3 0.0 0.054 13.7 0.0 1.4 1 0 0 1 1 1 0 SdrD B-like domain Big_9 PF17963.1 EFA77617.1 - 1.1e-12 48.5 16.8 5.3e-11 43.1 4.2 16.3 15 3 3 18 18 18 5 Bacterial Ig domain Laminin_EGF PF00053.24 EFA77617.1 - 3.2e-05 24.0 17.2 0.00041 20.4 8.4 2.5 1 1 1 2 2 2 2 Laminin EGF domain VWA PF00092.28 EFA77617.1 - 9e-05 22.8 0.1 0.00022 21.5 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Cadherin_3 PF16184.5 EFA77617.1 - 0.0012 18.9 15.7 2.7 8.0 0.1 7.2 7 0 0 7 7 7 2 Cadherin-like Cadherin_4 PF17803.1 EFA77617.1 - 0.004 17.7 3.4 0.004 17.7 3.4 14.8 15 2 1 16 16 16 5 Bacterial cadherin-like domain EGF_2 PF07974.13 EFA77617.1 - 0.025 14.9 26.3 0.018 15.4 6.2 3.3 3 0 0 3 3 3 0 EGF-like domain Cadherin_5 PF17892.1 EFA77617.1 - 0.026 14.5 49.2 0.076 13.0 0.7 10.7 10 3 1 11 11 11 0 Cadherin-like domain I-EGF_1 PF18372.1 EFA77617.1 - 0.057 13.5 12.9 0.26 11.4 3.7 2.6 2 0 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 hEGF PF12661.7 EFA77617.1 - 2.8 8.7 21.3 4.1 8.2 8.6 3.0 2 0 0 2 2 2 0 Human growth factor-like EGF zf-RING_2 PF13639.6 EFA77619.1 - 0.0016 18.7 13.7 0.0016 18.7 13.7 2.2 2 0 0 2 2 2 1 Ring finger domain zf-BED PF02892.15 EFA77619.1 - 0.097 12.7 3.4 0.32 11.0 0.4 3.0 2 0 0 2 2 2 0 BED zinc finger DUF3402 PF11882.8 EFA77619.1 - 0.83 8.7 9.1 2.9 6.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) zf-C3HC4_2 PF13923.6 EFA77619.1 - 3.7 7.5 18.9 1.1 9.2 14.3 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA77619.1 - 5.3 7.0 20.0 0.29 11.0 6.7 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFA77619.1 - 6.8 6.8 17.0 0.9 9.6 10.9 2.5 2 1 0 2 2 2 0 RING-type zinc-finger FAD_binding_3 PF01494.19 EFA77620.1 - 1.7e-72 244.6 0.0 2.7e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EFA77620.1 - 8e-08 31.8 0.1 1.2e-05 24.6 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFA77620.1 - 1.8e-06 27.8 0.1 8.7e-06 25.5 0.1 2.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA77620.1 - 1.8e-05 24.9 0.0 4.4e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFA77620.1 - 0.00097 18.4 0.1 0.0079 15.5 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA77620.1 - 0.0019 17.5 0.1 0.015 14.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFA77620.1 - 0.02 13.8 0.1 0.029 13.2 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EFA77620.1 - 0.031 13.5 0.1 0.064 12.5 0.1 1.5 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 EFA77620.1 - 0.044 13.1 0.1 0.081 12.3 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EFA77620.1 - 0.057 12.7 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EFA77620.1 - 0.059 13.9 0.1 0.29 11.7 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFA77620.1 - 0.069 12.4 0.0 4.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_7 PF13241.6 EFA77620.1 - 0.17 12.3 0.0 0.53 10.8 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4380 PF14315.6 EFA77622.1 - 0.005 15.8 0.0 0.64 8.9 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4380) dsDNA_bind PF01984.20 EFA77623.1 - 2.7e-30 104.9 18.1 3e-30 104.8 18.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF3616 PF12275.8 EFA77623.1 - 0.25 10.7 3.9 0.28 10.6 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) YjbH PF06082.11 EFA77623.1 - 6.1 5.5 7.4 7.1 5.3 7.4 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH RRM_1 PF00076.22 EFA77625.1 - 1e-29 102.1 0.2 1e-08 34.8 0.0 5.0 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 EFA77625.1 - 1.7e-08 34.4 10.2 0.073 13.1 0.0 5.2 4 1 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 U6-snRNA_bdg PF10596.9 EFA77625.1 - 0.074 13.0 1.8 0.09 12.7 0.1 2.0 2 0 0 2 2 2 0 U6-snRNA interacting domain of PrP8 zf-RING_2 PF13639.6 EFA77625.1 - 1.4 9.3 21.4 0.024 14.9 13.7 2.0 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 EFA77625.1 - 2.4 8.3 10.1 7.4 6.7 10.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger PIP5K PF01504.18 EFA77626.1 - 1.6e-74 250.6 8.7 2.5e-74 250.0 8.7 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SR-25 PF10500.9 EFA77626.1 - 0.91 9.1 7.0 1.5 8.4 7.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Palm_thioest PF02089.15 EFA77627.1 - 4.4e-55 187.2 0.4 5.2e-55 186.9 0.4 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EFA77627.1 - 0.002 17.7 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Dcc1 PF09724.9 EFA77629.1 - 5.6e-58 196.8 2.6 4.2e-57 194.0 2.6 1.9 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Cyclin_C PF02984.19 EFA77629.1 - 0.21 11.7 3.2 0.14 12.2 1.4 1.6 2 0 0 2 2 2 0 Cyclin, C-terminal domain MeaB PF03308.16 EFA77630.1 - 1.3e-89 299.7 0.0 1.9e-89 299.2 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EFA77630.1 - 7.5e-07 28.9 0.1 3.1e-06 26.9 0.1 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EFA77630.1 - 0.00023 21.0 1.3 0.029 14.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EFA77630.1 - 0.00054 19.8 1.2 0.004 17.0 0.1 2.4 2 1 0 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EFA77630.1 - 0.0021 18.1 0.3 0.03 14.4 0.3 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA77630.1 - 0.007 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFA77630.1 - 0.016 14.9 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain BRCC36_C PF18110.1 EFA77630.1 - 0.054 13.7 0.8 0.15 12.3 0.1 2.1 2 1 1 3 3 2 0 BRCC36 C-terminal helical domain AAA PF00004.29 EFA77630.1 - 0.065 13.7 0.6 0.31 11.5 0.1 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EFA77630.1 - 0.066 13.7 0.1 0.066 13.7 0.1 2.5 2 1 1 3 3 3 0 AAA domain RNA_helicase PF00910.22 EFA77630.1 - 0.076 13.4 1.1 0.24 11.8 0.0 2.5 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 EFA77630.1 - 0.1 12.7 0.1 0.37 11.0 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA77630.1 - 0.11 12.9 0.1 0.46 10.9 0.0 1.9 2 1 0 2 2 1 0 AAA ATPase domain NTPase_1 PF03266.15 EFA77630.1 - 0.11 12.4 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 EFA77630.1 - 0.12 12.9 0.4 0.39 11.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 EFA77630.1 - 0.14 11.5 0.0 0.3 10.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 EFA77630.1 - 0.28 11.7 0.2 0.28 11.7 0.2 2.7 4 1 0 4 4 3 0 AAA domain PI3Ka PF00613.20 EFA77631.1 - 2.3e-61 206.4 0.6 4.8e-61 205.4 0.6 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA77631.1 - 5.7e-55 186.8 0.1 2e-53 181.8 0.1 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EFA77631.1 - 1.2e-22 80.4 0.0 3.4e-22 78.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EFA77631.1 - 0.0052 16.2 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) HEAT_2 PF13646.6 EFA77631.1 - 0.016 15.6 0.2 0.13 12.7 0.0 2.2 2 0 0 2 2 2 0 HEAT repeats SUIM_assoc PF16619.5 EFA77632.1 - 2.2 8.4 15.2 3.2 7.9 3.0 4.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Ribonuc_L-PSP PF01042.21 EFA77633.1 - 9.8e-35 119.2 0.2 1.3e-34 118.8 0.2 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP Histone PF00125.24 EFA77634.1 - 3.3e-23 82.5 0.6 4e-23 82.2 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFA77634.1 - 3.6e-05 24.0 0.3 8.5e-05 22.8 0.3 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EFA77634.1 - 0.0022 18.5 0.0 0.0035 17.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 EFA77634.1 - 0.086 12.9 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 EFA77634.1 - 0.096 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 CENP-S protein Acyl_transf_3 PF01757.22 EFA77635.1 - 0.00017 20.7 6.7 0.00021 20.5 6.7 1.1 1 0 0 1 1 1 1 Acyltransferase family Pkinase PF00069.25 EFA77638.1 - 1.2e-52 178.9 0.0 2e-52 178.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77638.1 - 2.6e-35 121.9 0.0 5.2e-35 121.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA77638.1 - 0.00069 19.0 0.0 0.0016 17.8 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFA77638.1 - 0.0042 15.9 1.3 0.052 12.3 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFA77638.1 - 0.072 12.4 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SDP_N PF12278.8 EFA77639.1 - 0.037 14.2 1.6 0.061 13.5 1.6 1.3 1 0 0 1 1 1 0 Sex determination protein N terminal Alpha_kinase PF02816.18 EFA77641.1 - 2e-07 31.3 1.1 5.9e-07 29.8 0.6 2.0 2 0 0 2 2 2 1 Alpha-kinase family VWA PF00092.28 EFA77641.1 - 0.0025 18.1 0.0 0.0057 16.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Alpha_kinase PF02816.18 EFA77642.1 - 9.3e-17 61.7 0.2 1.2e-16 61.4 0.2 1.1 1 0 0 1 1 1 1 Alpha-kinase family Alpha_kinase PF02816.18 EFA77643.1 - 8.3e-44 149.9 1.8 8.3e-44 149.9 1.8 2.1 3 0 0 3 3 3 1 Alpha-kinase family Integrin_beta PF00362.18 EFA77643.1 - 0.011 15.5 0.2 2.2 7.8 0.3 2.5 2 0 0 2 2 2 0 Integrin beta chain VWA domain AMIN PF11741.8 EFA77643.1 - 0.14 12.3 0.0 25 5.1 0.0 2.6 2 0 0 2 2 2 0 AMIN domain Alpha_kinase PF02816.18 EFA77644.1 - 7.7e-51 172.8 5.6 7.8e-51 172.8 4.5 1.6 2 0 0 2 2 2 1 Alpha-kinase family VWA_2 PF13519.6 EFA77644.1 - 0.0017 19.0 0.0 0.0044 17.6 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_beta PF00362.18 EFA77644.1 - 1.6 8.3 8.8 5.7 6.5 0.3 3.4 3 1 1 4 4 4 0 Integrin beta chain VWA domain MIT PF04212.18 EFA77645.1 - 1.2e-09 38.1 0.5 2.3e-09 37.2 0.5 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Mitoc_L55 PF09776.9 EFA77645.1 - 0.052 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 FAD-SLDH PF12318.8 EFA77645.1 - 0.081 13.0 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase Glyco_hydro_38N PF01074.22 EFA77646.1 - 7.3e-77 258.6 2.0 1.1e-76 258.0 2.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Elf1 PF05129.13 EFA77646.1 - 2.6e-28 97.9 3.3 7.4e-28 96.4 3.3 1.8 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Glyco_hydro_38C PF07748.13 EFA77646.1 - 5e-17 62.7 0.1 9.9e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFA77646.1 - 1.9e-16 60.0 0.4 5.6e-16 58.5 0.2 2.0 2 0 0 2 2 2 1 Alpha mannosidase middle domain Abhydrolase_6 PF12697.7 EFA77647.1 - 4.2e-06 27.5 0.0 6e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA77647.1 - 7.3e-06 25.4 0.0 8.1e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA77647.1 - 2.4e-05 24.1 0.1 0.0021 17.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF676 PF05057.14 EFA77647.1 - 0.02 14.4 0.0 0.088 12.3 0.0 1.9 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Esterase PF00756.20 EFA77647.1 - 0.17 11.5 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF3789 PF12664.7 EFA77647.1 - 0.24 11.2 1.7 0.46 10.2 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) Aconitase PF00330.20 EFA77648.1 - 2.7e-181 603.6 0.0 3.4e-181 603.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFA77648.1 - 3.2e-37 127.8 0.0 5.8e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain UCH PF00443.29 EFA77649.1 - 1.9e-48 165.2 12.4 1.9e-48 165.2 12.4 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA77649.1 - 1.3e-16 61.1 22.1 1.3e-16 61.1 22.1 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFA77649.1 - 1.4e-14 54.1 19.5 1.4e-14 54.1 19.5 3.9 2 1 1 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Linker_histone PF00538.19 EFA77651.1 - 1.1e-20 73.7 0.4 1.1e-20 73.7 0.4 1.7 2 0 0 2 2 2 1 linker histone H1 and H5 family Ndc1_Nup PF09531.10 EFA77652.1 - 0.3 9.7 37.8 0.038 12.7 33.7 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup MAP7 PF05672.11 EFA77652.1 - 8.5 6.0 77.5 0.22 11.2 67.8 2.3 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Proteasome PF00227.26 EFA77653.1 - 7.8e-19 67.9 0.0 9.5e-19 67.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Met_synt_B12 PF02965.17 EFA77656.1 - 9.9e-118 392.5 0.0 1.6e-117 391.8 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 EFA77656.1 - 1.6e-77 260.9 0.0 3.4e-77 259.9 0.0 1.6 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 EFA77656.1 - 5.5e-57 193.3 1.2 1.2e-56 192.1 0.2 2.2 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 EFA77656.1 - 1e-22 80.3 3.1 3.5e-22 78.6 0.0 3.4 4 0 0 4 4 4 1 B12 binding domain B12-binding PF02310.19 EFA77656.1 - 3e-19 69.2 0.3 3.1e-18 66.0 0.2 2.7 2 0 0 2 2 2 1 B12 binding domain DUF4973 PF16343.5 EFA77656.1 - 0.072 13.1 0.3 2.1 8.4 0.3 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4973) Porphobil_deam PF01379.20 EFA77657.1 - 9.9e-80 266.8 0.0 1.3e-79 266.4 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EFA77657.1 - 4.2e-22 78.3 0.3 8e-22 77.4 0.3 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain ubiquitin PF00240.23 EFA77659.1 - 4.3e-10 39.2 0.2 7.7e-10 38.4 0.2 1.4 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA77659.1 - 1.3e-06 28.1 0.4 4.7e-06 26.3 0.4 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA77659.1 - 0.00012 22.5 0.1 0.00047 20.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain UN_NPL4 PF11543.8 EFA77659.1 - 0.027 14.9 0.0 0.039 14.4 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Ubiquitin_4 PF18036.1 EFA77659.1 - 0.033 14.2 0.3 0.43 10.7 0.1 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain USP7_C2 PF14533.6 EFA77659.1 - 0.096 12.4 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal TOBE_2 PF08402.10 EFA77659.1 - 0.1 12.8 0.0 6.9 6.9 0.0 2.2 2 0 0 2 2 2 0 TOBE domain Cobl PF09469.10 EFA77659.1 - 0.13 12.6 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Cordon-bleu ubiquitin-like domain Gln-synt_C PF00120.24 EFA77660.1 - 6.5e-92 308.2 0.0 8e-92 307.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 EFA77660.1 - 0.093 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain Inositol_P PF00459.25 EFA77661.1 - 6.4e-69 232.5 0.0 7.3e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Glyco_transf_22 PF03901.17 EFA77662.1 - 2.3e-103 346.7 41.7 3.2e-103 346.2 41.7 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family EPL1 PF10513.9 EFA77662.1 - 0.25 11.7 0.1 0.25 11.7 0.1 2.8 2 1 1 3 3 3 0 Enhancer of polycomb-like U3_assoc_6 PF08640.11 EFA77662.1 - 1.1 9.4 7.0 0.17 12.0 1.3 2.6 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 Pkinase PF00069.25 EFA77663.1 - 2.5e-69 233.6 0.0 3.7e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77663.1 - 1.4e-34 119.6 0.2 1.9e-34 119.1 0.2 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA77663.1 - 7.3e-05 22.2 0.2 0.002 17.5 0.0 2.3 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFA77663.1 - 0.0043 16.1 2.1 0.011 14.6 2.1 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFA77663.1 - 0.0098 15.3 0.6 0.016 14.5 0.6 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA77663.1 - 0.041 13.8 0.0 3.4 7.5 0.0 2.8 2 1 0 3 3 3 0 Phosphotransferase enzyme family Peptidase_S9 PF00326.21 EFA77664.1 - 5.8e-06 25.9 0.1 1.1e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFA77664.1 - 0.011 16.3 0.1 0.023 15.3 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family S_layer_C PF05124.12 EFA77664.1 - 0.097 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 S-layer like family, C-terminal region PGAP1 PF07819.13 EFA77664.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Copine PF07002.16 EFA77665.1 - 4.1e-64 216.0 0.0 6.2e-64 215.4 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFA77665.1 - 1.6e-19 70.1 0.3 1e-09 38.6 0.1 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFA77665.1 - 0.00021 21.5 0.0 0.00038 20.6 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DER1 PF04511.15 EFA77668.1 - 3.1e-55 187.1 15.5 3.6e-55 186.9 15.5 1.0 1 0 0 1 1 1 1 Der1-like family DUF1331 PF07048.11 EFA77668.1 - 0.0072 16.0 0.0 0.024 14.3 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1331) DUF4133 PF13571.6 EFA77668.1 - 0.32 11.4 4.6 0.35 11.2 2.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4133) STT3 PF02516.14 EFA77669.1 - 2.3e-136 455.6 42.5 5.9e-131 437.8 39.7 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit GATA PF00320.27 EFA77670.1 - 2.9e-17 62.0 4.9 5.6e-17 61.1 4.9 1.5 1 0 0 1 1 1 1 GATA zinc finger Glyco_hydro_9 PF00759.19 EFA77671.1 - 2.2e-129 432.5 8.0 3.1e-129 432.0 8.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Pirin PF02678.16 EFA77672.1 - 1.5e-37 127.8 0.1 5.7e-36 122.8 0.0 2.2 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 EFA77672.1 - 2.1e-19 69.8 0.0 6.9e-18 64.9 0.0 2.2 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EFA77672.1 - 0.00032 20.4 0.3 0.8 9.5 0.1 2.4 2 0 0 2 2 2 2 Cupin domain DUF726 PF05277.12 EFA77673.1 - 3.3e-62 210.4 7.3 1.7e-58 198.2 1.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF726) VPS9 PF02204.18 EFA77673.1 - 6.3e-30 103.5 0.7 4e-29 100.9 0.6 2.4 3 0 0 3 3 3 1 Vacuolar sorting protein 9 (VPS9) domain zf-met2 PF12907.7 EFA77673.1 - 4.2e-12 46.0 3.1 9.3e-12 44.9 3.1 1.6 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 EFA77673.1 - 1.1e-06 29.4 11.1 3.1e-06 27.9 11.1 1.8 1 0 0 1 1 1 1 4F5 protein family Herpes_UL46 PF03387.14 EFA77673.1 - 0.0043 15.8 0.7 0.0043 15.8 0.7 1.5 2 0 0 2 2 2 1 Herpesvirus UL46 protein FeoB_Cyto PF17910.1 EFA77673.1 - 0.2 12.2 1.2 0.91 10.1 0.1 2.8 3 0 0 3 3 3 0 FeoB cytosolic helical domain UCH PF00443.29 EFA77674.1 - 1.7e-45 155.5 1.4 1.7e-45 155.5 1.4 4.0 4 0 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA77674.1 - 4.7e-30 105.3 0.6 4.7e-30 105.3 0.6 3.4 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFA77674.1 - 5.9e-07 29.1 0.1 1.6e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family RepB-RCR_reg PF10723.9 EFA77675.1 - 0.046 13.7 0.6 0.046 13.7 0.6 1.8 1 1 1 2 2 2 0 Replication regulatory protein RepB Cytochrom_C PF00034.21 EFA77676.1 - 0.56 11.4 3.3 1.4 10.1 1.6 2.6 2 1 1 3 3 3 0 Cytochrome c Metallophos PF00149.28 EFA77677.1 - 5.1e-31 108.8 1.0 8.3e-31 108.1 1.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EFA77677.1 - 9.6e-26 89.9 1.1 2.5e-25 88.6 1.1 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_2 PF07719.17 EFA77677.1 - 7e-13 47.6 1.0 9.5e-05 22.2 0.0 3.7 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA77677.1 - 5.8e-10 38.6 3.9 0.0081 16.0 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA77677.1 - 7.9e-07 28.7 2.0 0.0036 17.0 0.0 2.7 3 0 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 EFA77677.1 - 9.7e-05 22.8 0.2 0.0035 17.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA77677.1 - 0.00022 21.2 0.2 0.094 13.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA77677.1 - 0.0026 18.4 0.0 3 8.6 0.0 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA77677.1 - 0.026 15.0 0.2 0.13 12.8 0.0 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA77677.1 - 0.1 13.4 0.0 2.2 9.3 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA77677.1 - 0.15 12.5 0.4 2.9 8.5 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Baculo_PEP_C PF04513.12 EFA77678.1 - 0.018 15.1 3.3 0.04 14.0 3.3 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lipoprotein_7 PF01540.16 EFA77678.1 - 0.13 11.6 2.1 0.2 10.9 2.1 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein TetR_C_24 PF17932.1 EFA77678.1 - 0.17 12.1 0.5 0.32 11.3 0.5 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF5082 PF16888.5 EFA77678.1 - 1.2 9.4 15.1 0.082 13.2 9.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF4407 PF14362.6 EFA77678.1 - 8.5 5.6 9.4 0.29 10.4 3.6 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Acyltransferase PF01553.21 EFA77679.1 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase DUF5463 PF17551.2 EFA77679.1 - 0.31 11.0 3.5 0.69 9.9 3.5 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5463) Baculo_IE-1 PF05290.11 EFA77679.1 - 0.57 10.1 5.1 0.96 9.4 5.1 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) MpPF26 PF07666.11 EFA77679.1 - 9 6.4 13.4 16 5.6 13.4 1.3 1 0 0 1 1 1 0 M penetrans paralogue family 26 Myb_DNA-binding PF00249.31 EFA77680.1 - 2.8e-12 46.6 0.2 4.6e-12 45.9 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFA77680.1 - 0.00019 21.3 0.3 0.00054 19.8 0.3 1.8 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFA77680.1 - 0.07 13.4 0.1 0.2 11.9 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain RRP36 PF06102.12 EFA77680.1 - 0.23 11.4 1.6 2.5 8.1 0.2 2.4 1 1 1 2 2 2 0 rRNA biogenesis protein RRP36 Cation_efflux PF01545.21 EFA77681.1 - 5.2e-27 94.9 12.1 6.7e-27 94.5 12.1 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFA77681.1 - 5e-11 42.6 0.0 9.3e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter NnrS PF05940.12 EFA77681.1 - 0.23 10.8 3.9 0.3 10.4 3.9 1.1 1 0 0 1 1 1 0 NnrS protein Pkinase PF00069.25 EFA77682.1 - 8e-66 222.1 0.0 6.5e-64 215.8 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77682.1 - 2.1e-30 105.9 0.2 3.7e-21 75.6 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA77682.1 - 4.1e-07 29.6 0.0 0.099 11.9 0.0 3.1 3 0 0 3 3 3 3 Kinase-like APH PF01636.23 EFA77682.1 - 0.00022 21.2 0.0 0.29 11.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFA77682.1 - 0.00025 20.1 0.1 0.00043 19.3 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EFA77682.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EFA77682.1 - 0.017 14.5 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Actin PF00022.19 EFA77683.1 - 3.9e-147 490.1 0.0 1.3e-146 488.4 0.0 1.7 1 1 0 1 1 1 1 Actin Pkinase PF00069.25 EFA77684.1 - 7.1e-71 238.7 0.1 1.7e-70 237.4 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77684.1 - 3.1e-35 121.7 0.4 6.8e-35 120.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.18 EFA77684.1 - 2.9e-24 85.0 6.0 7.7e-14 51.6 0.0 3.7 3 0 0 3 3 3 2 POLO box duplicated region DHHC PF01529.20 EFA77685.1 - 5.4e-37 126.9 14.1 5.4e-37 126.9 14.1 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase CDC45 PF02724.14 EFA77685.1 - 0.0022 16.4 0.0 0.0024 16.2 0.0 1.1 1 0 0 1 1 1 1 CDC45-like protein BNIP2 PF12496.8 EFA77685.1 - 0.6 10.5 8.0 0.86 10.0 8.0 1.2 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CDC27 PF09507.10 EFA77685.1 - 1.1 8.6 16.3 1.4 8.3 16.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 ABC_tran PF00005.27 EFA77686.1 - 6.3e-26 91.5 0.0 1.1e-25 90.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA77686.1 - 1.2e-24 87.1 31.6 1.6e-24 86.6 31.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA77686.1 - 1.5e-10 41.4 0.4 1.5e-05 25.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFA77686.1 - 1.3e-05 25.8 0.0 3.5e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 EFA77686.1 - 0.0054 16.9 0.0 0.13 12.6 0.0 2.6 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFA77686.1 - 0.018 14.8 0.1 0.035 13.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EFA77686.1 - 0.12 11.8 0.1 1.9 7.8 0.1 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 EFA77686.1 - 0.2 11.4 0.0 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF2070 PF09843.9 EFA77686.1 - 2.4 6.4 8.3 4.8 5.4 8.3 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ribosomal_S24e PF01282.19 EFA77687.1 - 5.6e-31 106.3 0.1 5.6e-31 106.3 0.1 1.8 1 1 1 2 2 2 1 Ribosomal protein S24e Cmc1 PF08583.10 EFA77688.1 - 5.9e-16 58.3 9.0 7.6e-16 57.9 9.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 EFA77688.1 - 0.012 16.0 4.0 0.025 15.0 4.0 1.5 1 0 0 1 1 1 0 GCK domain NDUF_B7 PF05676.13 EFA77688.1 - 0.018 14.7 1.0 0.028 14.1 1.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CX9C PF16860.5 EFA77688.1 - 0.039 14.0 4.0 0.064 13.3 4.0 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 EFA77688.1 - 0.48 10.8 6.6 3.6 8.0 6.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.13 EFA77688.1 - 1.7 8.9 8.1 15 5.9 8.5 2.0 1 1 1 2 2 2 0 CHCH domain TBP PF00352.21 EFA77689.1 - 6.8e-41 138.1 1.6 1.3e-31 108.3 0.1 3.0 2 1 1 3 3 3 3 Transcription factor TFIID (or TATA-binding protein, TBP) DUF4295 PF14128.6 EFA77689.1 - 0.032 14.1 0.3 0.17 11.7 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) DUF3378 PF11858.8 EFA77689.1 - 0.036 14.2 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3378) CSN8_PSD8_EIF3K PF10075.9 EFA77690.1 - 1.7e-15 57.3 0.2 4.3e-13 49.5 0.1 2.3 2 0 0 2 2 2 2 CSN8/PSMD8/EIF3K family IL2 PF00715.17 EFA77690.1 - 0.063 13.2 0.0 0.18 11.7 0.0 1.7 1 1 0 1 1 1 0 Interleukin 2 PTEN_C2 PF10409.9 EFA77691.1 - 2.6e-21 75.8 0.2 2.6e-21 75.8 0.2 2.2 1 1 1 2 2 2 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EFA77691.1 - 3.9e-09 36.4 0.0 9.4e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA77691.1 - 6.5e-08 32.4 1.4 7e-08 32.3 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFA77691.1 - 0.018 15.1 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFA77691.1 - 0.12 12.5 0.4 0.42 10.7 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate DUF5327 PF17261.2 EFA77691.1 - 0.13 13.1 7.6 0.25 12.1 7.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5327) TFIIA PF03153.13 EFA77691.1 - 1.2 9.0 18.3 1.8 8.5 18.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 EFA77691.1 - 4.1 8.4 6.4 8.8 7.4 6.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pkinase PF00069.25 EFA77693.1 - 9.1e-72 241.6 0.3 1.6e-71 240.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA77693.1 - 5.4e-51 173.3 0.3 1.1e-50 172.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA77693.1 - 8.6e-07 28.1 0.0 8.6e-07 28.1 0.0 2.9 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 EFA77693.1 - 0.013 14.9 0.0 0.043 13.1 0.0 1.8 1 1 0 1 1 1 0 Kinase-like ABC1 PF03109.16 EFA77693.1 - 0.1 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Frizzled PF01534.17 EFA77694.1 - 4.8e-10 39.0 22.8 7.4e-10 38.4 22.8 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 EFA77694.1 - 3.7e-06 27.5 3.3 7.8e-06 26.5 3.3 1.5 1 0 0 1 1 1 1 Fz domain YpmT PF17431.2 EFA77694.1 - 0.27 11.3 6.6 0.19 11.8 2.2 2.6 2 0 0 2 2 2 0 Uncharacterized YmpT-like Acyl-CoA_dh_1 PF00441.24 EFA77695.1 - 2.2e-24 86.4 0.1 3.2e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFA77695.1 - 1.4e-22 79.6 0.0 2.4e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EFA77695.1 - 6.8e-20 71.8 0.0 1.1e-19 71.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFA77695.1 - 8.4e-06 26.1 0.0 2.2e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HEAT PF02985.22 EFA77696.1 - 4.5e-12 45.1 5.2 0.21 11.9 0.1 8.5 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EFA77696.1 - 0.00054 20.3 0.1 2.6 8.5 0.0 5.8 7 0 0 7 7 7 1 HEAT repeats HEAT_EZ PF13513.6 EFA77696.1 - 0.0036 17.8 0.2 12 6.5 0.0 5.4 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 EFA77696.1 - 0.0045 17.0 13.8 0.65 10.0 0.2 6.2 7 0 0 7 7 7 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EFA77696.1 - 0.051 13.8 2.2 7.7 6.7 0.0 5.1 6 1 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 Pneumovirus_M2 PF06436.11 EFA77696.1 - 0.084 12.4 2.0 0.096 12.2 0.2 2.0 2 0 0 2 2 2 0 Pneumovirus matrix protein 2 (M2) Cohesin_HEAT PF12765.7 EFA77696.1 - 0.11 12.9 1.5 3.7 7.9 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion Aldedh PF00171.22 EFA77696.1 - 0.18 10.3 0.0 0.29 9.6 0.0 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Vault PF01505.18 EFA77697.1 - 2.2e-58 194.1 0.4 2.4e-16 59.6 0.1 5.0 5 0 0 5 5 5 4 Major Vault Protein repeat domain MVP_shoulder PF11978.8 EFA77697.1 - 1.7e-46 157.0 0.0 3.3e-46 156.1 0.0 1.5 1 0 0 1 1 1 1 Shoulder domain Vault_2 PF17794.1 EFA77697.1 - 3.4e-36 123.4 0.1 2.5e-23 82.2 0.1 2.6 2 0 0 2 2 2 2 Major Vault Protein repeat domain Vault_3 PF17795.1 EFA77697.1 - 2.9e-34 116.9 0.5 2.3e-29 101.2 0.0 3.4 3 0 0 3 3 3 2 Major Vault Protein Repeat domain Vault_4 PF17796.1 EFA77697.1 - 5.2e-22 77.7 0.0 1e-20 73.6 0.1 2.6 2 0 0 2 2 2 1 Major Vault Protein repeat domain RAI16-like PF10257.9 EFA77698.1 - 1.2e-85 287.6 9.9 3e-85 286.3 9.9 1.7 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein SPX PF03105.19 EFA77698.1 - 0.028 14.3 7.6 0.22 11.4 5.6 2.4 2 1 0 2 2 2 0 SPX domain Tom5 PF10642.9 EFA77698.1 - 0.25 11.4 0.6 3.5 7.7 0.1 2.7 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Dicty_CTDC PF00526.18 EFA77699.1 - 1.3e-40 136.9 189.2 4.9e-09 35.9 17.0 13.4 12 1 0 12 12 12 10 Dictyostelium (slime mold) repeat LIM PF00412.22 EFA77701.1 - 1.3e-11 44.6 6.9 1.8e-11 44.1 6.9 1.2 1 0 0 1 1 1 1 LIM domain zf-C3HC4_2 PF13923.6 EFA77701.1 - 0.22 11.4 4.4 1.5 8.7 0.5 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4428 PF14471.6 EFA77701.1 - 0.73 9.8 3.7 0.28 11.2 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) C1_1 PF00130.22 EFA77701.1 - 0.84 9.6 8.0 0.36 10.7 2.5 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-SNAP50_C PF12251.8 EFA77701.1 - 1.2 8.8 8.2 0.16 11.6 2.1 2.0 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal zf-B_box PF00643.24 EFA77702.1 - 1.1e-08 35.1 10.8 1.1e-08 35.1 10.8 1.9 2 0 0 2 2 2 1 B-box zinc finger Cor1 PF04803.12 EFA77702.1 - 0.14 12.4 7.0 1.3 9.3 7.8 2.1 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Kelch_1 PF01344.25 EFA77702.1 - 0.14 11.7 0.0 2.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Kelch motif Synaptobrevin PF00957.21 EFA77703.1 - 5.6e-13 48.5 1.6 8.6e-13 47.9 1.6 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFA77703.1 - 9.6e-06 25.6 0.0 1.6e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Mod_r PF07200.13 EFA77703.1 - 0.034 14.3 1.1 0.049 13.8 1.1 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CelTOS PF18659.1 EFA77703.1 - 0.045 14.2 0.7 0.099 13.1 0.7 1.5 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites SpoU_sub_bind PF08032.12 EFA77703.1 - 0.083 13.2 0.4 0.25 11.6 0.4 1.8 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding SE PF08491.10 EFA77704.1 - 2.7e-88 295.6 0.0 3.8e-88 295.1 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EFA77704.1 - 1.4e-12 47.5 0.0 2.4e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFA77704.1 - 0.0026 17.1 0.8 0.0038 16.5 0.2 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA77704.1 - 0.0034 17.0 0.3 0.048 13.2 0.6 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFA77704.1 - 0.0073 15.4 0.5 0.14 11.2 0.3 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EFA77704.1 - 0.0083 15.0 0.2 3.8 6.2 0.2 3.0 3 0 0 3 3 3 1 Tryptophan halogenase NAD_binding_8 PF13450.6 EFA77704.1 - 0.017 15.4 0.7 0.048 13.9 0.7 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GDI PF00996.18 EFA77704.1 - 0.021 13.4 0.0 0.036 12.6 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor FAD_binding_2 PF00890.24 EFA77704.1 - 0.041 13.0 1.6 0.062 12.4 1.6 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EFA77704.1 - 0.055 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EFA77704.1 - 0.083 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 EFA77704.1 - 0.1 11.3 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Pullulanase_Ins PF18494.1 EFA77705.1 - 0.28 11.7 2.6 0.57 10.7 0.3 2.3 2 0 0 2 2 2 0 Pullulanase Ins domain DPPIV_N PF00930.21 EFA77706.1 - 1.3e-67 228.1 3.6 2.2e-67 227.4 3.6 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EFA77706.1 - 4e-49 167.0 0.0 7.9e-49 166.0 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFA77706.1 - 2.1e-06 27.5 0.0 7.3e-05 22.5 0.0 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EFA77706.1 - 0.00034 20.4 0.0 0.0034 17.1 0.0 2.2 2 0 0 2 2 2 1 Putative esterase Tap-RNA_bind PF09162.10 EFA77706.1 - 0.035 13.9 0.7 0.09 12.6 0.7 1.6 1 0 0 1 1 1 0 Tap, RNA-binding Abhydrolase_1 PF00561.20 EFA77706.1 - 0.037 13.7 0.0 0.092 12.4 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Ank_2 PF12796.7 EFA77707.1 - 5.6e-19 68.5 4.4 1.6e-05 25.4 0.0 5.0 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA77707.1 - 1.5e-17 63.4 1.9 0.24 11.8 0.0 8.9 4 2 5 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77707.1 - 2.5e-14 52.0 4.3 6.2 7.7 0.0 9.8 11 0 0 11 11 11 3 Ankyrin repeat Ank_4 PF13637.6 EFA77707.1 - 4e-11 43.2 11.6 0.31 11.7 0.1 8.0 5 4 4 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 EFA77707.1 - 0.35 11.4 1.8 1.5e+02 3.1 0.0 5.0 6 1 0 6 6 6 0 Ankyrin repeat Mit_KHE1 PF10173.9 EFA77709.1 - 0.018 15.2 10.5 0.031 14.4 10.5 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related TFIIA PF03153.13 EFA77709.1 - 1 9.3 25.5 1.6 8.7 25.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit F-box-like PF12937.7 EFA77710.1 - 0.011 15.6 0.2 0.05 13.5 0.2 2.1 1 0 0 1 1 1 0 F-box-like F-box_5 PF18511.1 EFA77710.1 - 0.61 9.7 2.2 0.93 9.1 1.1 1.8 2 0 0 2 2 2 0 F-box Membralin PF09746.9 EFA77711.1 - 2e-06 27.1 9.5 2e-06 27.1 9.5 3.1 1 1 2 3 3 2 2 Tumour-associated protein NEMP PF10225.9 EFA77711.1 - 0.0079 15.9 2.9 0.016 14.9 2.9 1.5 1 0 0 1 1 1 1 NEMP family DDHD PF02862.17 EFA77711.1 - 0.012 15.8 6.5 0.052 13.7 2.1 2.1 2 0 0 2 2 2 0 DDHD domain AIF_C PF14721.6 EFA77711.1 - 0.018 15.4 2.4 0.018 15.4 2.4 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CCDC53 PF10152.9 EFA77711.1 - 0.036 14.5 9.4 0.041 14.3 2.3 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex SpoIIP PF07454.11 EFA77711.1 - 0.037 13.5 15.9 0.81 9.1 9.4 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 EFA77711.1 - 0.04 14.1 0.5 0.04 14.1 0.5 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PH PF00169.29 EFA77711.1 - 0.18 12.3 1.2 0.46 11.0 1.2 1.7 1 0 0 1 1 1 0 PH domain Spt20 PF12090.8 EFA77711.1 - 0.18 11.4 38.1 0.65 9.6 30.5 2.4 2 0 0 2 2 2 0 Spt20 family DUF5308 PF17233.2 EFA77711.1 - 0.95 9.7 7.8 0.3 11.3 4.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Lig_chan PF00060.26 EFA77711.1 - 3.1 7.6 5.6 30 4.4 2.9 2.7 2 0 0 2 2 2 0 Ligand-gated ion channel G0-G1_switch_2 PF15103.6 EFA77711.1 - 4.7 7.7 7.6 2.2 8.8 4.1 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 Folliculin PF11704.8 EFA77711.1 - 5.5 6.8 12.1 1.2 9.0 7.3 2.0 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4199 PF13858.6 EFA77711.1 - 6.3 7.2 21.7 0.23 11.8 12.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4199) FAM60A PF15396.6 EFA77711.1 - 6.6 6.7 14.8 5.6 6.9 1.2 2.1 2 0 0 2 2 2 0 Protein Family FAM60A FAM176 PF14851.6 EFA77711.1 - 8.1 6.1 10.5 0.37 10.4 2.2 2.1 2 0 0 2 2 2 0 FAM176 family PCYCGC PF13798.6 EFA77711.1 - 8.6 6.2 7.7 8.7 6.2 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function with PCYCGC motif PP2C PF00481.21 EFA77712.1 - 2.6e-53 181.3 0.0 5.4e-39 134.4 0.0 3.1 2 1 0 2 2 2 2 Protein phosphatase 2C TCRP1 PF14944.6 EFA77712.1 - 0.0088 16.0 2.3 0.0088 16.0 2.3 1.7 2 0 0 2 2 2 1 Tongue Cancer Chemotherapy Resistant Protein 1 XRN_N PF03159.18 EFA77713.1 - 2.5e-22 79.5 5.6 2.5e-22 79.5 5.6 3.4 2 2 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFA77713.1 - 6.2e-11 41.9 3.5 6.2e-11 41.9 3.5 4.3 3 2 1 4 4 4 1 Xrn1 helical domain CDC45 PF02724.14 EFA77713.1 - 0.0013 17.1 15.0 0.0013 17.1 15.0 3.0 2 1 0 2 2 2 1 CDC45-like protein DEAD PF00270.29 EFA77714.1 - 2.1e-43 148.1 0.5 4e-43 147.2 0.5 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA77714.1 - 1.8e-28 99.1 1.8 1.7e-27 96.0 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA77714.1 - 2.9e-05 24.1 0.0 5.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFA77714.1 - 0.0057 17.0 1.1 0.016 15.6 0.6 2.0 2 1 0 2 2 2 1 AAA domain CMS1 PF14617.6 EFA77714.1 - 0.0077 15.6 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 EFA77714.1 - 0.03 14.2 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_30 PF13604.6 EFA77714.1 - 0.045 13.5 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain tRNA-synt_1b PF00579.25 EFA77714.1 - 0.075 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Fanconi_A PF03511.14 EFA77714.1 - 0.18 11.8 0.1 0.68 9.9 0.0 2.0 2 0 0 2 2 2 0 Fanconi anaemia group A protein Elf4 PF07011.11 EFA77714.1 - 0.37 10.7 2.3 1.3 9.0 0.1 2.8 3 1 0 3 3 3 0 Early Flowering 4 domain AATF-Che1 PF13339.6 EFA77715.1 - 3e-26 92.8 4.0 3e-26 92.8 4.0 4.0 3 2 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 EFA77715.1 - 1.6e-20 73.4 0.3 1.6e-20 73.4 0.3 3.8 4 0 0 4 4 4 1 Apoptosis-antagonizing transcription factor, C-terminal DASH_Dad3 PF08656.10 EFA77715.1 - 1 9.5 4.3 0.58 10.3 0.5 2.6 3 0 0 3 3 3 0 DASH complex subunit Dad3 G8 PF10162.9 EFA77717.1 - 1.4e-23 83.3 0.0 2.9e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 EFA77717.1 - 3.6 7.4 12.4 6.8 6.5 1.1 3.5 3 1 0 3 3 3 0 Right handed beta helix region RRM_1 PF00076.22 EFA77718.1 - 2.2e-51 171.6 5.0 2.1e-18 65.9 0.1 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA77718.1 - 1.5e-07 31.1 0.2 0.11 12.1 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA77718.1 - 5.4e-06 26.4 0.3 0.019 15.1 0.0 3.9 3 2 0 3 3 3 1 RNA recognition motif RNA_bind PF08675.11 EFA77718.1 - 0.00092 19.2 0.0 0.2 11.7 0.0 2.8 2 0 0 2 2 2 1 RNA binding domain PHM7_cyt PF14703.6 EFA77718.1 - 0.002 18.4 0.5 4.5 7.5 0.0 3.8 2 1 2 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter DUF4078 PF13300.6 EFA77718.1 - 0.071 13.4 2.5 0.78 10.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4078) SWIM PF04434.17 EFA77719.1 - 0.005 16.5 0.2 0.005 16.5 0.2 1.7 2 0 0 2 2 2 1 SWIM zinc finger GRAM PF02893.20 EFA77720.1 - 9.1e-19 67.4 3.3 3.7e-10 39.7 0.7 2.7 2 0 0 2 2 2 2 GRAM domain Chromate_transp PF02417.15 EFA77720.1 - 2.3e-08 34.3 16.8 1.3e-07 31.9 4.2 2.3 2 0 0 2 2 2 2 Chromate transporter YlaC PF10777.9 EFA77720.1 - 0.0067 16.3 1.2 0.0067 16.3 1.2 2.2 2 0 0 2 2 2 1 Inner membrane protein YlaC DUF2113 PF09886.9 EFA77720.1 - 0.017 14.4 0.5 0.85 8.9 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2113) Vps36_ESCRT-II PF11605.8 EFA77720.1 - 0.057 13.6 0.7 19 5.5 0.1 2.8 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 DUF1461 PF07314.11 EFA77721.1 - 0.77 9.6 6.7 35 4.2 6.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) SUR7 PF06687.12 EFA77721.1 - 1.8 8.1 10.3 0.034 13.8 0.9 2.4 3 0 0 3 3 3 0 SUR7/PalI family ADH_zinc_N PF00107.26 EFA77722.1 - 3.2e-09 36.9 0.3 6.8e-09 35.8 0.3 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 EFA77722.1 - 0.016 15.1 0.2 0.026 14.4 0.2 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Exo_endo_phos PF03372.23 EFA77723.1 - 2.5e-13 50.1 0.0 3.5e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family EPL1 PF10513.9 EFA77723.1 - 0.82 10.0 8.1 1.5 9.2 8.1 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like Macoilin PF09726.9 EFA77723.1 - 1.9 7.0 9.6 2.5 6.6 9.6 1.2 1 0 0 1 1 1 0 Macoilin family RasGEF PF00617.19 EFA77724.1 - 9.9e-44 149.6 1.2 9.9e-44 149.6 1.2 3.2 4 0 0 4 4 4 1 RasGEF domain RasGEF_N PF00618.20 EFA77724.1 - 3.7e-20 72.1 0.5 3.7e-20 72.1 0.5 4.9 5 0 0 5 5 5 1 RasGEF N-terminal motif ATP_bind_1 PF03029.17 EFA77724.1 - 0.064 13.0 0.4 0.26 11.0 0.2 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CDC24_OB1 PF17246.2 EFA77725.1 - 2e-28 98.9 11.1 2e-28 98.9 11.1 3.3 2 1 0 2 2 2 1 Cell division control protein 24, OB domain 1 CDC24_OB3 PF17244.2 EFA77725.1 - 9.6e-17 61.4 2.5 9.6e-17 61.4 2.5 3.0 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 CDC24_OB2 PF17245.2 EFA77725.1 - 5.1e-15 56.2 1.6 4e-14 53.3 1.6 2.7 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 2 GST_C_3 PF14497.6 EFA77725.1 - 1.1e-14 54.4 0.8 3.9e-14 52.6 0.2 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA77725.1 - 3.8e-11 43.2 0.0 1.6e-10 41.1 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA77725.1 - 2.1e-06 27.8 0.1 5.4e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA77725.1 - 0.019 15.0 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Xpo1 PF08389.12 EFA77728.1 - 1.2e-10 41.7 2.8 1.4e-10 41.5 0.2 2.2 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 EFA77728.1 - 7.2e-08 32.2 0.4 3e-07 30.2 0.4 2.1 1 1 0 1 1 1 1 Importin-beta N-terminal domain Glyoxalase_2 PF12681.7 EFA77728.1 - 0.0043 17.0 3.0 0.0077 16.2 2.6 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain MIP-T3_C PF17749.1 EFA77729.1 - 0.01 15.8 0.6 0.029 14.4 0.6 1.7 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region RXT2_N PF08595.11 EFA77729.1 - 0.15 12.1 6.3 0.44 10.6 6.3 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 EFA77729.1 - 0.31 11.4 15.3 0.36 11.2 13.5 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3439 PF11921.8 EFA77729.1 - 0.33 10.9 2.4 0.71 9.8 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Cwf_Cwc_15 PF04889.12 EFA77729.1 - 0.43 10.3 12.7 0.87 9.3 12.7 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EFA77729.1 - 2.9 7.1 15.3 5 6.3 15.3 1.3 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 EFA77729.1 - 5 6.8 7.7 13 5.4 7.7 1.7 1 0 0 1 1 1 0 FAM176 family Mid2 PF04478.12 EFA77730.1 - 5.9e-05 22.9 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor TNFR_16_TM PF18422.1 EFA77730.1 - 0.015 15.3 0.8 0.036 14.0 0.8 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TMEM154 PF15102.6 EFA77730.1 - 0.023 14.6 0.2 0.041 13.8 0.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF4448 PF14610.6 EFA77730.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF1325 PF07039.11 EFA77732.1 - 1.3e-31 109.4 1.1 1.3e-31 109.4 1.1 2.2 2 0 0 2 2 2 1 SGF29 tudor-like domain Tudor_3 PF18115.1 EFA77732.1 - 3.2e-06 26.9 1.0 5.3e-06 26.2 0.2 1.8 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 EFA77732.1 - 1.9e-05 24.7 0.0 3.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) TUDOR_5 PF18359.1 EFA77732.1 - 0.0033 17.1 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 TFIIF_alpha PF05793.12 EFA77732.1 - 0.019 13.6 25.3 0.025 13.2 25.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LBR_tudor PF09465.10 EFA77732.1 - 0.032 14.1 0.1 6.7 6.6 0.1 2.5 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain Tudor-knot PF11717.8 EFA77732.1 - 0.046 13.6 0.0 4 7.4 0.0 2.8 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Utp14 PF04615.13 EFA77732.1 - 0.16 10.5 20.1 0.2 10.2 20.1 1.1 1 0 0 1 1 1 0 Utp14 protein Macoilin PF09726.9 EFA77732.1 - 1.2 7.6 17.1 1.4 7.4 17.1 1.2 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 EFA77732.1 - 3.9 5.5 15.0 5 5.1 15.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 EFA77732.1 - 6.7 3.7 14.2 7.2 3.6 14.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FNIP PF05725.12 EFA77733.1 - 6.5e-45 151.0 23.0 1.4e-16 60.4 0.2 7.5 7 0 0 7 7 7 6 FNIP Repeat F-box-like PF12937.7 EFA77733.1 - 0.0024 17.7 0.7 0.0079 16.1 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 EFA77733.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 F-box Ribosomal_S7e PF01251.18 EFA77734.1 - 0.0091 15.8 2.1 0.012 15.3 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S7e ING PF12998.7 EFA77734.1 - 0.065 13.8 2.2 0.11 13.0 2.2 1.5 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding SR-25 PF10500.9 EFA77735.1 - 1.1 8.9 14.4 1.7 8.2 14.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein His_Phos_1 PF00300.22 EFA77736.1 - 1.1e-34 119.8 0.0 1.8e-28 99.6 0.0 2.0 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) SRP1_TIP1 PF00660.17 EFA77737.1 - 0.048 13.7 0.1 0.077 13.1 0.1 1.3 1 0 0 1 1 1 0 Seripauperin and TIP1 family Spore_III_AF PF09581.10 EFA77737.1 - 0.39 10.7 2.2 0.5 10.4 0.1 2.0 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) zf-C3HC4_2 PF13923.6 EFA77738.1 - 1.2e-11 44.2 10.3 2.1e-11 43.5 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA77738.1 - 1.6e-09 37.5 11.5 3e-09 36.6 11.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA77738.1 - 3.3e-09 36.4 8.7 5.1e-09 35.8 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA77738.1 - 3.6e-09 36.5 8.4 7.6e-09 35.5 8.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA77738.1 - 5.6e-09 35.8 9.9 9.8e-09 35.0 9.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA77738.1 - 8.6e-09 35.6 9.2 1.5e-08 34.8 9.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFA77738.1 - 3.4e-07 30.3 11.3 6.6e-07 29.4 11.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EFA77738.1 - 6.6e-05 22.7 8.9 0.00017 21.3 8.9 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EFA77738.1 - 7.2e-05 23.0 7.8 0.00026 21.2 7.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFA77738.1 - 0.00012 21.8 9.2 0.0012 18.6 9.4 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EFA77738.1 - 0.014 15.3 4.0 0.028 14.3 4.0 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein BUD22 PF09073.10 EFA77738.1 - 0.015 14.7 27.6 0.27 10.6 1.6 2.2 2 0 0 2 2 2 0 BUD22 Rad50_zn_hook PF04423.14 EFA77738.1 - 0.7 9.8 0.1 0.7 9.8 0.1 2.5 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-P11 PF03854.14 EFA77738.1 - 0.99 9.1 5.1 1.9 8.2 5.1 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 EFA77738.1 - 1.1 9.1 7.9 4.8 7.1 7.9 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EFA77738.1 - 1.3 9.3 8.3 2.6 8.3 8.3 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 GAGA PF09237.11 EFA77738.1 - 2 8.3 5.3 0.22 11.4 0.5 1.9 2 0 0 2 2 2 0 GAGA factor zf-RING_11 PF17123.5 EFA77738.1 - 2.6 7.9 5.8 6.3 6.6 4.6 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-MIZ PF02891.20 EFA77738.1 - 4 7.3 10.9 11 5.9 10.9 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger ATP-synt_S1 PF05827.12 EFA77739.1 - 1.6e-07 31.3 0.2 1.6e-07 31.3 0.2 1.8 2 1 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) RPA43_OB PF17875.1 EFA77740.1 - 1.3e-05 25.8 0.0 1.3e-05 25.8 0.0 5.1 2 2 1 3 3 3 2 RPA43 OB domain in RNA Pol I CDC45 PF02724.14 EFA77740.1 - 0.0008 17.8 31.7 0.0012 17.3 31.7 1.3 1 0 0 1 1 1 1 CDC45-like protein TFIIF_alpha PF05793.12 EFA77740.1 - 0.014 14.0 50.4 0.019 13.6 50.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 EFA77740.1 - 0.16 10.5 40.4 0.2 10.2 40.4 1.1 1 0 0 1 1 1 0 Macoilin family SRP-alpha_N PF04086.13 EFA77740.1 - 2.3 8.1 48.3 3.2 7.6 48.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Nop14 PF04147.12 EFA77740.1 - 3 5.9 46.1 4.1 5.5 46.1 1.1 1 0 0 1 1 1 0 Nop14-like family F_actin_cap_B PF01115.17 EFA77741.1 - 5e-105 350.4 0.0 5.8e-105 350.2 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 EFA77741.1 - 0.00059 19.3 0.0 0.002 17.6 0.0 1.9 1 1 0 1 1 1 1 F-actin capping protein alpha subunit Ank_2 PF12796.7 EFA77743.1 - 2.5e-28 98.5 8.2 4.7e-06 27.1 0.0 6.0 4 2 1 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77743.1 - 5.1e-26 90.7 3.4 1.7e-06 28.4 0.0 9.3 8 1 1 9 9 9 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77743.1 - 3.8e-17 62.1 7.2 0.0072 16.6 0.0 9.6 3 2 7 11 11 11 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77743.1 - 8.8e-16 56.4 6.5 2.1 9.2 0.0 11.9 13 1 1 14 14 14 4 Ankyrin repeat Peroxin-22 PF12827.7 EFA77743.1 - 0.013 15.4 0.4 1.3 8.9 0.0 3.2 3 0 0 3 3 3 0 Peroxisomal biogenesis protein family DUF5049 PF16468.5 EFA77743.1 - 0.056 13.4 0.0 31 4.6 0.0 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA77743.1 - 0.1 13.1 1.4 81 3.9 0.0 4.8 2 1 0 2 2 2 0 Ankyrin repeat FAT PF02259.23 EFA77745.1 - 1.7e-108 362.9 0.8 1.7e-108 362.9 0.8 3.6 3 1 1 4 4 4 1 FAT domain PI3_PI4_kinase PF00454.27 EFA77745.1 - 1.5e-73 247.7 0.1 3.5e-72 243.2 0.1 2.7 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EFA77745.1 - 7.9e-66 220.9 4.2 3.8e-60 202.4 0.0 5.6 5 2 1 6 6 6 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EFA77745.1 - 3.3e-41 139.7 0.2 3.3e-41 139.7 0.2 4.0 5 1 0 5 5 4 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EFA77745.1 - 9e-19 67.7 16.8 0.0015 18.9 0.0 10.2 7 2 3 10 10 10 4 HEAT repeats HEAT PF02985.22 EFA77745.1 - 5.3e-14 51.1 27.0 0.013 15.6 0.0 13.1 14 0 0 14 14 13 3 HEAT repeat FATC PF02260.20 EFA77745.1 - 1e-13 50.8 0.2 2.6e-13 49.5 0.2 1.7 1 0 0 1 1 1 1 FATC domain Cnd1 PF12717.7 EFA77745.1 - 9.3e-13 48.5 6.4 0.0013 18.8 0.0 6.8 4 2 2 7 7 7 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFA77745.1 - 2.1e-08 34.5 22.3 0.00041 20.8 0.1 10.9 12 2 2 14 14 11 2 HEAT-like repeat IFRD PF05004.13 EFA77745.1 - 1e-06 28.1 3.3 0.00064 18.9 0.0 5.0 4 1 1 5 5 5 1 Interferon-related developmental regulator (IFRD) Sec7_N PF12783.7 EFA77745.1 - 1.3e-06 28.4 1.2 0.11 12.4 0.0 4.3 3 1 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Vac14_Fab1_bd PF12755.7 EFA77745.1 - 4.7e-06 27.1 0.7 19 6.0 0.0 6.4 5 2 1 6 6 5 0 Vacuolar 14 Fab1-binding region UME PF08064.13 EFA77745.1 - 2.3e-05 24.2 6.1 2.2 8.2 0.1 7.0 7 1 1 8 8 8 1 UME (NUC010) domain ParcG PF10274.9 EFA77745.1 - 0.0019 18.3 10.4 11 6.1 0.1 6.3 5 2 2 7 7 7 0 Parkin co-regulated protein CLASP_N PF12348.8 EFA77745.1 - 0.0032 17.0 2.1 0.3 10.6 0.0 4.9 5 1 0 5 5 5 1 CLASP N terminal RNase_H2-Ydr279 PF09468.10 EFA77745.1 - 0.024 14.8 0.0 0.21 11.8 0.0 2.5 2 0 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain RTP1_C1 PF10363.9 EFA77745.1 - 0.037 14.2 2.1 68 3.7 0.0 5.5 5 1 1 6 6 5 0 Required for nuclear transport of RNA pol II C-terminus 1 TPR_19 PF14559.6 EFA77745.1 - 0.063 13.8 0.0 1.6 9.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA77745.1 - 0.11 12.6 1.4 1.6 9.0 0.1 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat Kelch_6 PF13964.6 EFA77746.1 - 2.1e-08 34.1 3.5 8.3e-05 22.7 0.1 4.1 4 0 0 4 4 4 2 Kelch motif zf-B_box PF00643.24 EFA77746.1 - 2.3e-06 27.6 8.6 5.2e-06 26.5 8.6 1.6 1 0 0 1 1 1 1 B-box zinc finger DUF5074 PF16819.5 EFA77746.1 - 0.0095 16.0 0.7 0.0095 16.0 0.7 4.8 5 1 0 5 5 5 1 Domain of unknown function (DUF5074) Kelch_1 PF01344.25 EFA77746.1 - 0.044 13.4 0.4 7.5 6.2 0.0 2.9 3 0 0 3 3 3 0 Kelch motif zf-UBP PF02148.19 EFA77746.1 - 0.25 11.7 3.9 0.98 9.8 3.9 2.0 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein UPF0449 PF15136.6 EFA77746.1 - 0.85 10.1 5.8 0.2 12.2 0.3 2.7 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 PHD PF00628.29 EFA77747.1 - 0.15 12.0 18.1 0.053 13.4 3.0 2.5 2 0 0 2 2 2 0 PHD-finger FH2 PF02181.23 EFA77748.1 - 1.4e-92 310.7 9.4 2.1e-92 310.1 2.8 2.4 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFA77748.1 - 8.2e-34 116.9 1.5 8.2e-34 116.9 1.5 2.9 3 0 0 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EFA77748.1 - 6.5e-31 107.4 0.5 3.7e-30 104.9 0.4 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Angiomotin_C PF12240.8 EFA77748.1 - 0.0027 17.3 0.9 0.0059 16.2 0.9 1.5 1 0 0 1 1 1 1 Angiomotin C terminal FlaC_arch PF05377.11 EFA77748.1 - 0.0043 17.4 14.7 0.025 15.0 1.4 5.0 5 0 0 5 5 5 1 Flagella accessory protein C (FlaC) BST2 PF16716.5 EFA77748.1 - 0.0084 16.7 2.9 0.0084 16.7 2.9 4.7 5 1 1 6 6 4 1 Bone marrow stromal antigen 2 GOLGA2L5 PF15070.6 EFA77748.1 - 0.0099 14.6 0.7 0.0099 14.6 0.7 2.7 3 0 0 3 3 3 1 Putative golgin subfamily A member 2-like protein 5 DUF724 PF05266.14 EFA77748.1 - 0.027 14.3 0.3 0.027 14.3 0.3 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF724) TolA_bind_tri PF16331.5 EFA77748.1 - 0.032 14.3 5.1 4.2 7.5 0.3 3.8 3 0 0 3 3 3 0 TolA binding protein trimerisation DUF4094 PF13334.6 EFA77748.1 - 0.036 14.5 0.6 0.18 12.2 0.6 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) HALZ PF02183.18 EFA77748.1 - 0.084 13.1 13.9 1.7 9.0 0.4 4.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.9 EFA77748.1 - 0.2 11.7 15.2 0.11 12.5 2.0 3.6 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Het-C PF07217.11 EFA77748.1 - 0.23 9.9 1.1 0.46 8.9 1.1 1.4 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CENP-F_N PF10481.9 EFA77748.1 - 0.84 9.2 10.4 0.11 12.1 3.7 2.8 3 1 0 3 3 3 0 Cenp-F N-terminal domain Med9 PF07544.13 EFA77748.1 - 0.93 9.6 12.7 1.9 8.7 0.0 4.2 4 0 0 4 4 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF3450 PF11932.8 EFA77748.1 - 1 8.6 9.2 0.97 8.7 4.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FlgN PF05130.12 EFA77748.1 - 1.2 9.7 16.0 1.6 9.3 2.5 4.1 3 1 1 4 4 4 0 FlgN protein Lectin_N PF03954.14 EFA77748.1 - 1.3 8.7 11.3 1.9 8.2 1.7 3.4 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Phage_GPO PF05929.11 EFA77748.1 - 1.3 8.6 9.3 0.63 9.6 2.9 2.7 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase CEP209_CC5 PF16574.5 EFA77748.1 - 1.6 8.9 7.1 1.4 9.1 0.4 3.3 3 0 0 3 3 3 0 Coiled-coil region of centrosome protein CE290 bZIP_1 PF00170.21 EFA77748.1 - 2.2 8.5 22.2 0.2 11.8 2.8 4.8 5 0 0 5 5 4 0 bZIP transcription factor DUF1664 PF07889.12 EFA77748.1 - 2.5 8.1 12.5 2.3 8.3 4.7 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Baculo_p24 PF05073.12 EFA77748.1 - 3 7.6 7.3 1.2 8.9 3.0 2.4 2 1 1 3 3 3 0 Baculovirus P24 capsid protein SlyX PF04102.12 EFA77748.1 - 3.2 8.4 11.9 4.6 7.9 0.1 4.7 4 1 0 4 4 3 0 SlyX NPV_P10 PF05531.12 EFA77748.1 - 3.8 8.1 10.6 6.2 7.4 2.0 4.9 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Nnf1 PF03980.14 EFA77748.1 - 4.3 7.8 7.3 8.7 6.8 0.4 3.7 3 0 0 3 3 3 0 Nnf1 PI3K_P85_iSH2 PF16454.5 EFA77748.1 - 5.5 6.6 9.2 1.2 8.7 4.0 2.7 2 1 0 2 2 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4407 PF14362.6 EFA77748.1 - 5.8 6.2 9.1 0.77 9.1 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SHE3 PF17078.5 EFA77748.1 - 6.1 6.5 15.5 0.43 10.3 0.1 4.9 5 0 0 5 5 4 0 SWI5-dependent HO expression protein 3 Filament PF00038.21 EFA77748.1 - 6.5 6.2 11.7 0.7 9.4 3.0 3.4 3 1 0 3 3 3 0 Intermediate filament protein FapA PF03961.13 EFA77748.1 - 6.8 5.2 6.2 1.9 7.0 1.0 2.5 2 1 1 3 3 3 0 Flagellar Assembly Protein A DnaJ_C PF01556.18 EFA77749.1 - 4.1e-37 127.5 0.5 5.5e-37 127.1 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFA77749.1 - 3.2e-24 84.8 3.1 5e-24 84.2 3.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFA77749.1 - 1.5e-13 50.9 22.7 2.9e-13 50.0 22.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFA77749.1 - 3e-05 23.9 12.0 0.0018 18.2 3.3 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EFA77749.1 - 0.00013 21.9 9.0 0.011 15.8 3.5 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 EFA77749.1 - 0.53 9.9 8.5 1.2 8.7 1.6 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-C3HC4_3 PF13920.6 EFA77749.1 - 1.1 9.2 8.7 0.35 10.8 1.7 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 EFA77749.1 - 1.4 9.0 13.1 6.8 6.8 13.2 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_10 PF16685.5 EFA77749.1 - 1.7 8.8 6.9 1.3 9.2 0.8 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 zinc_ribbon_9 PF14369.6 EFA77749.1 - 1.9 8.8 9.9 8.3 6.8 0.4 3.3 2 1 0 2 2 2 0 zinc-ribbon 7tm_3 PF00003.22 EFA77750.1 - 6.6e-40 137.3 26.0 6.6e-40 137.3 26.0 1.7 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA77750.1 - 2.5e-20 72.7 0.8 3.5e-20 72.2 0.8 1.1 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like DUF3332 PF11810.8 EFA77750.1 - 0.21 11.2 2.8 0.45 10.2 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Adeno_E3B PF03376.14 EFA77751.1 - 0.19 12.0 2.8 0.35 11.1 2.8 1.5 1 1 0 1 1 1 0 Adenovirus E3B protein CRAL_TRIO PF00650.20 EFA77752.1 - 1.1e-34 119.4 0.1 1.8e-34 118.8 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFA77752.1 - 1.1e-08 35.1 0.1 2.4e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFA77752.1 - 0.0018 18.4 0.0 0.0031 17.7 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain AvrM_N PF18247.1 EFA77752.1 - 0.1 12.6 0.1 0.34 10.9 0.1 1.9 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain GATA PF00320.27 EFA77753.1 - 1.3e-16 59.9 6.7 2.6e-16 58.9 6.7 1.6 1 0 0 1 1 1 1 GATA zinc finger zinc_ribbon_9 PF14369.6 EFA77753.1 - 0.17 12.2 1.5 0.31 11.3 1.5 1.5 1 0 0 1 1 1 0 zinc-ribbon Acetyltransf_10 PF13673.7 EFA77754.1 - 6e-07 29.4 0.0 9.8e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA77754.1 - 0.00022 21.6 0.0 0.0004 20.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA77754.1 - 0.0026 18.0 0.0 0.0039 17.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Arcadin_1 PF18653.1 EFA77754.1 - 0.027 14.5 0.2 0.047 13.7 0.2 1.3 1 0 0 1 1 1 0 Arcadin 1 Coiled PF05710.12 EFA77755.1 - 7e-07 30.0 4.1 7.7e-07 29.9 4.1 1.1 1 0 0 1 1 1 1 Coiled coil HlyIII PF03006.20 EFA77756.1 - 4.9e-60 203.0 25.1 6e-60 202.7 25.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related PDDEXK_6 PF04720.12 EFA77756.1 - 4 7.3 6.5 5.7 6.8 6.5 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Coiled PF05710.12 EFA77757.1 - 0.037 14.8 5.9 0.043 14.7 5.9 1.1 1 0 0 1 1 1 0 Coiled coil Coiled PF05710.12 EFA77758.1 - 4.5e-05 24.2 19.8 0.00016 22.4 2.9 2.2 2 0 0 2 2 2 2 Coiled coil HlyD_D23 PF16576.5 EFA77758.1 - 0.073 12.3 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion FAD_binding_1 PF00667.20 EFA77759.1 - 4.4e-42 144.2 0.1 6.5e-42 143.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFA77759.1 - 3.9e-29 101.7 0.0 7.4e-29 100.8 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFA77759.1 - 7.2e-09 36.3 0.2 2.4e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFA77759.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Kelch_6 PF13964.6 EFA77760.1 - 1.8e-17 62.9 0.2 2.9e-05 24.2 0.0 4.0 2 1 1 3 3 3 3 Kelch motif Kelch_1 PF01344.25 EFA77760.1 - 1.6e-09 37.2 2.1 0.00013 21.5 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EFA77760.1 - 2.3e-08 33.9 7.4 0.023 14.7 0.0 4.1 5 0 0 5 5 5 3 Galactose oxidase, central domain zf-B_box PF00643.24 EFA77760.1 - 0.0051 16.9 7.3 0.012 15.8 7.3 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA77760.1 - 0.016 15.4 0.4 8 6.9 0.0 4.0 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA77760.1 - 0.054 13.5 0.5 15 5.8 0.0 4.2 4 0 0 4 4 4 0 Kelch motif POX PF07526.11 EFA77760.1 - 0.22 12.1 2.7 4.1 8.0 0.1 2.9 3 0 0 3 3 3 0 Associated with HOX NDK PF00334.19 EFA77761.1 - 4.6e-52 175.6 0.0 6e-52 175.2 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Epimerase PF01370.21 EFA77763.1 - 5.3e-24 85.0 0.0 8.3e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA77763.1 - 2.5e-22 79.2 0.1 4.3e-22 78.4 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFA77763.1 - 3.4e-21 75.6 0.1 9.6e-21 74.1 0.1 1.7 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFA77763.1 - 3.4e-18 66.1 0.2 7.9e-17 61.6 0.1 2.3 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFA77763.1 - 2.5e-16 60.1 0.0 3.7e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFA77763.1 - 5.1e-11 42.2 0.1 1.3e-10 40.9 0.1 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EFA77763.1 - 1.4e-08 34.4 0.0 4.6e-06 26.2 0.0 2.8 3 1 0 3 3 3 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 EFA77763.1 - 2.9e-08 33.2 0.0 4.5e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 EFA77763.1 - 3.3e-08 33.4 0.0 1.5e-07 31.3 0.0 2.0 1 1 0 1 1 1 1 NmrA-like family KR PF08659.10 EFA77763.1 - 4.1e-06 26.8 0.1 1.6e-05 24.9 0.1 1.9 1 1 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EFA77763.1 - 0.0076 16.3 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EFA77763.1 - 0.026 15.1 0.0 0.091 13.3 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent EF-hand_6 PF13405.6 EFA77763.1 - 0.059 13.3 0.0 0.28 11.2 0.0 2.2 2 0 0 2 2 1 0 EF-hand domain ABC_tran PF00005.27 EFA77764.1 - 1.7e-33 116.1 0.7 5.3e-33 114.4 0.0 2.2 3 0 0 3 3 3 1 ABC transporter ABC_membrane PF00664.23 EFA77764.1 - 4.3e-17 62.7 3.1 4.3e-17 62.7 3.1 1.7 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EFA77764.1 - 6.1e-07 29.1 0.1 9.5e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFA77764.1 - 0.00071 19.3 0.0 0.0022 17.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFA77764.1 - 0.0032 17.9 0.7 0.0092 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFA77764.1 - 0.0033 17.3 0.0 0.011 15.7 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EFA77764.1 - 0.0085 16.4 0.7 0.075 13.3 0.2 2.6 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFA77764.1 - 0.022 14.1 0.0 0.062 12.6 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 EFA77764.1 - 0.026 15.1 0.3 0.29 11.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFA77764.1 - 0.055 13.4 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase SbcCD_C PF13558.6 EFA77764.1 - 0.058 13.6 0.4 0.75 10.1 0.4 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 EFA77764.1 - 0.074 12.6 0.1 0.93 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Interferon PF00143.19 EFA77765.1 - 0.005 17.0 0.3 0.0092 16.2 0.3 1.5 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF4686 PF15742.5 EFA77765.1 - 0.0068 15.6 3.2 0.0072 15.5 2.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4686) Pex26 PF07163.12 EFA77765.1 - 0.0095 15.3 0.2 0.011 15.1 0.2 1.1 1 0 0 1 1 1 1 Pex26 protein R-HINP1I PF11463.8 EFA77765.1 - 0.032 13.7 2.8 0.03 13.8 1.4 1.5 1 1 1 2 2 2 0 R.HinP1I restriction endonuclease Hrs_helical PF12210.8 EFA77765.1 - 0.037 14.6 0.9 0.3 11.6 0.1 2.2 1 1 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate CK2S PF15011.6 EFA77765.1 - 0.041 13.8 1.3 0.3 11.0 0.1 2.1 2 0 0 2 2 2 0 Casein Kinase 2 substrate CorA PF01544.18 EFA77765.1 - 0.061 12.6 4.5 0.1 11.9 4.5 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein GRP PF07172.11 EFA77766.1 - 2.3e-07 31.4 4.5 2.8e-07 31.1 4.5 1.1 1 0 0 1 1 1 1 Glycine rich protein family DUF1180 PF06679.12 EFA77766.1 - 0.14 12.6 0.0 0.15 12.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2207 PF09972.9 EFA77768.1 - 0.00033 19.6 2.8 0.00036 19.4 2.8 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) CrgA PF06781.12 EFA77768.1 - 0.02 14.9 0.1 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 Cell division protein CrgA Sigma_reg_N PF13800.6 EFA77768.1 - 0.026 14.8 2.3 0.055 13.8 1.5 2.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal UL45 PF05473.12 EFA77768.1 - 0.067 12.8 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like E1-E2_ATPase PF00122.20 EFA77768.1 - 0.08 12.5 0.2 0.13 11.8 0.2 1.3 1 0 0 1 1 1 0 E1-E2 ATPase Synaptobrevin PF00957.21 EFA77768.1 - 0.31 10.8 5.0 0.64 9.8 5.0 1.7 1 1 0 1 1 1 0 Synaptobrevin DUF5383 PF17355.2 EFA77768.1 - 3.8 7.9 9.6 0.82 10.0 3.7 2.1 1 1 0 2 2 2 0 Family of unknown function (DUF5383) DUF3899 PF13038.6 EFA77768.1 - 6.1 7.4 6.9 20 5.8 6.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) NIF3 PF01784.18 EFA77769.1 - 3e-68 230.1 0.2 4.3e-68 229.6 0.2 1.2 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) YqgF PF14639.6 EFA77769.1 - 0.046 13.5 0.3 0.084 12.6 0.3 1.4 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Peptidase_M8 PF01457.16 EFA77770.1 - 9e-44 150.0 3.0 2e-43 148.9 3.0 1.4 1 1 0 1 1 1 1 Leishmanolysin Peptidase_M8 PF01457.16 EFA77771.1 - 9.8e-51 173.0 0.2 2e-50 172.0 0.2 1.4 1 0 0 1 1 1 1 Leishmanolysin MMR_HSR1 PF01926.23 EFA77772.1 - 3.7e-15 56.0 1.2 1.2e-14 54.4 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA77772.1 - 5.2e-07 29.3 1.2 4.6e-06 26.2 1.2 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA77772.1 - 6.3e-07 29.4 3.4 9.2e-05 22.4 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 EFA77772.1 - 1.4e-06 28.0 0.7 0.00019 21.1 0.8 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFA77772.1 - 6.7e-06 26.3 6.1 3.5e-05 23.9 0.1 3.6 3 1 1 4 4 4 1 Dynamin family Roc PF08477.13 EFA77772.1 - 0.005 17.0 1.5 0.014 15.6 0.0 2.5 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFA77772.1 - 0.011 15.1 0.3 0.011 15.1 0.3 2.8 2 2 0 2 2 2 0 AIG1 family ABC_tran PF00005.27 EFA77772.1 - 0.046 14.2 1.1 0.29 11.7 0.0 2.4 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 EFA77772.1 - 0.062 13.7 0.8 1.9 8.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase MORN PF02493.20 EFA77773.1 - 3.3e-14 51.8 14.8 0.0018 18.0 0.1 6.4 6 0 0 6 6 6 4 MORN repeat SET PF00856.28 EFA77773.1 - 3.4e-06 27.6 1.4 3.6e-05 24.2 0.1 2.8 2 1 0 2 2 2 1 SET domain BUD22 PF09073.10 EFA77773.1 - 2.9 7.1 16.2 2.2 7.5 14.4 1.7 2 0 0 2 2 2 0 BUD22 WD40 PF00400.32 EFA77774.1 - 2.8e-16 59.6 7.6 0.00014 22.5 0.0 6.2 4 1 0 4 4 4 4 WD domain, G-beta repeat Adeno_E3_15_3 PF03307.14 EFA77774.1 - 0.011 15.7 0.0 0.033 14.2 0.0 1.8 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region Pkinase_Tyr PF07714.17 EFA77775.1 - 1.1e-52 178.9 0.0 1.8e-52 178.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA77775.1 - 6.3e-44 150.3 0.0 1.4e-43 149.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 EFA77775.1 - 2.5e-37 128.6 0.0 5.1e-37 127.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 EFA77775.1 - 2.4e-26 92.3 0.4 6.7e-25 87.6 0.3 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA77775.1 - 1.6e-15 57.0 0.4 6.2e-14 51.9 0.3 2.4 2 0 0 2 2 2 1 Ras family Arf PF00025.21 EFA77775.1 - 8.1e-12 44.9 0.3 2.6e-10 40.1 0.2 2.8 3 0 0 3 3 3 1 ADP-ribosylation factor family LRR_8 PF13855.6 EFA77775.1 - 1.3e-09 37.6 7.2 1.8e-07 30.8 0.8 3.3 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EFA77775.1 - 3.3e-07 30.5 13.0 2.3e-05 24.7 3.1 4.4 4 1 2 6 6 4 3 Leucine Rich repeats (2 copies) MMR_HSR1 PF01926.23 EFA77775.1 - 7.6e-05 22.8 0.2 0.00039 20.5 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFA77775.1 - 0.00013 22.5 0.2 0.0023 18.4 0.1 2.8 2 0 0 2 2 2 1 ABC transporter Gtr1_RagA PF04670.12 EFA77775.1 - 0.00051 19.5 0.2 0.0021 17.5 0.1 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA77775.1 - 0.00075 19.4 2.3 0.022 14.6 0.6 2.9 3 0 0 3 3 3 1 RsgA GTPase FeoB_N PF02421.18 EFA77775.1 - 0.0028 17.2 0.2 0.036 13.6 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B PduV-EutP PF10662.9 EFA77775.1 - 0.026 14.2 0.7 0.088 12.5 0.7 1.9 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EFA77775.1 - 0.16 11.5 0.4 0.46 10.0 0.4 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC1 PF03109.16 EFA77775.1 - 0.23 11.6 1.0 1 9.5 0.1 2.4 2 1 0 2 2 1 0 ABC1 family Septin PF00735.18 EFA77775.1 - 0.31 10.3 1.7 0.5 9.6 0.5 1.9 2 0 0 2 2 2 0 Septin LRR_1 PF00560.33 EFA77775.1 - 0.33 11.6 10.8 16 6.6 0.1 5.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 EFA77775.1 - 2.6 8.3 8.1 0.85 9.8 0.2 3.6 3 0 0 3 3 3 0 Leucine Rich repeat Sec8_exocyst PF04048.14 EFA77776.1 - 9.6e-16 58.0 0.4 9.6e-16 58.0 0.4 3.4 4 0 0 4 4 4 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.9 EFA77776.1 - 0.02 14.7 4.1 0.012 15.4 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2451) Presenilin PF01080.17 EFA77776.1 - 6.7 5.4 7.5 11 4.7 7.5 1.2 1 0 0 1 1 1 0 Presenilin Rap_GAP PF02145.15 EFA77777.1 - 1e-36 126.2 5.5 3.6e-20 72.3 0.0 3.3 3 0 0 3 3 3 2 Rap/ran-GAP RPEL PF02755.15 EFA77777.1 - 0.012 15.3 1.5 0.022 14.5 1.5 1.5 1 0 0 1 1 1 0 RPEL repeat DUF3439 PF11921.8 EFA77778.1 - 1.3 9.0 11.0 3 7.8 11.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CAP_GLY PF01302.25 EFA77780.1 - 5.8e-17 61.5 0.1 9e-17 60.9 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EFA77780.1 - 0.12 12.9 52.6 1 9.9 14.2 4.7 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) SPOUT_MTase PF02590.17 EFA77780.1 - 0.18 11.8 1.0 0.49 10.4 0.1 2.1 2 1 0 2 2 2 0 Predicted SPOUT methyltransferase LRR_8 PF13855.6 EFA77780.1 - 0.73 9.7 38.5 0.55 10.0 10.0 4.3 3 2 0 3 3 3 0 Leucine rich repeat LIM PF00412.22 EFA77782.1 - 4.3e-29 100.5 36.5 3.4e-12 46.4 5.0 5.3 5 0 0 5 5 5 5 LIM domain TF_Zn_Ribbon PF08271.12 EFA77782.1 - 0.071 12.6 0.2 0.071 12.6 0.2 6.2 7 1 1 8 8 8 0 TFIIB zinc-binding DpnI PF06044.12 EFA77782.1 - 3.7 7.2 6.4 30 4.2 0.0 3.3 3 0 0 3 3 3 0 Dam-replacing family Cellulase PF00150.18 EFA77783.1 - 3.9e-35 121.6 1.9 7.7e-35 120.7 1.9 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM49 PF09478.10 EFA77783.1 - 5.4e-10 39.4 7.1 5.4e-10 39.4 7.1 3.1 2 1 0 2 2 2 1 Carbohydrate binding domain CBM49 Rap_GAP PF02145.15 EFA77784.1 - 4.9e-49 166.4 0.1 1.6e-48 164.8 0.1 1.9 1 0 0 1 1 1 1 Rap/ran-GAP DUF775 PF05603.12 EFA77784.1 - 2.3 7.7 6.4 0.6 9.6 1.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF775) LRR_6 PF13516.6 EFA77785.1 - 3.6e-38 126.4 31.2 0.00031 20.5 0.2 13.4 13 0 0 13 13 13 11 Leucine Rich repeat LRR_4 PF12799.7 EFA77785.1 - 5.9e-09 36.1 31.3 0.0041 17.5 0.1 8.7 5 2 0 7 7 7 5 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 EFA77785.1 - 0.00033 20.9 0.2 0.017 15.4 0.0 3.2 2 1 1 3 3 3 2 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.6 EFA77785.1 - 0.00081 19.1 35.3 0.15 11.9 1.2 9.3 5 5 4 9 9 9 5 Leucine rich repeat ADH_zinc_N PF00107.26 EFA77786.1 - 6.3e-26 90.9 0.0 1e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA77786.1 - 7.1e-20 72.4 0.0 2.1e-19 70.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA77786.1 - 1.1e-07 31.7 0.0 2.7e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF4921 PF16268.5 EFA77786.1 - 0.028 13.3 0.0 0.1 11.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4921) AAA_12 PF13087.6 EFA77791.1 - 1.1e-41 142.6 0.2 3.5e-41 141.0 0.2 1.9 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFA77791.1 - 6.4e-29 101.5 0.9 6.4e-29 101.5 0.9 2.4 2 2 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA77791.1 - 2.3e-09 37.2 0.0 1.9e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFA77791.1 - 8.7e-09 35.9 0.0 7.1e-08 32.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EFA77791.1 - 1.3e-07 31.2 0.1 0.00038 19.8 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) SAM_1 PF00536.30 EFA77791.1 - 2.2e-07 31.2 0.1 5.5e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA77791.1 - 4.5e-05 23.5 0.0 0.00012 22.1 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ResIII PF04851.15 EFA77791.1 - 0.00071 19.6 0.0 0.0027 17.7 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA77791.1 - 0.0025 17.6 0.2 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA77791.1 - 0.0032 17.7 0.1 0.064 13.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain SAM_Ste50p PF09235.10 EFA77791.1 - 0.013 15.7 0.2 0.055 13.7 0.2 2.2 1 0 0 1 1 1 0 Ste50p, sterile alpha motif AAA PF00004.29 EFA77791.1 - 0.026 15.0 0.2 0.35 11.3 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Glyco_tranf_2_3 PF13641.6 EFA77791.1 - 0.033 14.1 0.0 0.67 9.8 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase like family 2 PhoH PF02562.16 EFA77791.1 - 0.035 13.5 0.0 0.4 10.1 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 EFA77791.1 - 0.055 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EFA77791.1 - 0.075 12.6 0.0 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 EFA77791.1 - 0.13 11.7 11.1 0.013 15.0 2.5 3.5 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_12 PF13087.6 EFA77792.1 - 2e-40 138.5 0.7 2e-40 138.5 0.7 3.2 3 0 0 3 3 2 1 AAA domain AAA_11 PF13086.6 EFA77792.1 - 3.8e-26 92.5 5.4 3.8e-26 92.5 5.4 3.7 3 2 0 3 3 2 1 AAA domain SAM_1 PF00536.30 EFA77792.1 - 1.7e-11 44.4 1.0 1.1e-10 41.8 0.0 2.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) AAA_19 PF13245.6 EFA77792.1 - 5.8e-10 39.7 0.1 2.3e-08 34.5 0.1 3.0 2 1 0 2 2 2 1 AAA domain SAM_2 PF07647.17 EFA77792.1 - 3.6e-08 33.4 0.0 2e-07 31.0 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) AAA_30 PF13604.6 EFA77792.1 - 4.9e-08 32.9 0.0 0.00013 21.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EFA77792.1 - 1.6e-05 24.4 11.0 0.0014 17.9 0.0 3.6 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) zf_CCCH_4 PF18345.1 EFA77792.1 - 0.00022 21.2 5.8 0.00022 21.2 5.8 3.0 2 0 0 2 2 2 1 Zinc finger domain SAM_PNT PF02198.16 EFA77792.1 - 0.0037 17.2 0.0 0.0091 16.0 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PhoH PF02562.16 EFA77792.1 - 0.026 14.0 0.0 0.1 12.0 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.29 EFA77792.1 - 0.098 12.4 3.8 0.92 9.3 0.0 2.9 3 1 1 4 4 4 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA77792.1 - 0.27 11.5 6.4 0.56 10.5 0.0 4.0 5 0 0 5 5 5 0 AAA domain VASt PF16016.5 EFA77793.1 - 4.7e-31 108.3 0.2 4.7e-31 108.3 0.2 2.6 2 1 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain SK_channel PF03530.14 EFA77793.1 - 0.023 14.7 9.2 0.12 12.3 9.2 2.1 1 1 0 1 1 1 0 Calcium-activated SK potassium channel IF-2B PF01008.17 EFA77795.1 - 1.8e-70 237.4 0.0 2.1e-70 237.1 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family SIR2 PF02146.17 EFA77796.1 - 1.1e-55 188.3 0.0 1.9e-55 187.5 0.0 1.4 1 0 0 1 1 1 1 Sir2 family zf-UBP PF02148.19 EFA77796.1 - 8.8e-16 58.0 13.1 8.8e-16 58.0 13.1 2.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Dicty_REP PF05086.12 EFA77796.1 - 0.011 13.8 6.6 0.014 13.4 6.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CBM49 PF09478.10 EFA77797.1 - 1.3e-14 54.2 6.1 1.3e-14 54.2 6.1 2.2 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 Nucleotid_trans PF03407.16 EFA77798.1 - 7.6e-30 104.5 0.0 7.6e-29 101.2 0.0 2.2 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase WD40 PF00400.32 EFA77798.1 - 1.4e-16 60.5 13.5 0.0024 18.7 1.4 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 EFA77798.1 - 1.2e-06 27.5 8.0 0.13 10.9 0.1 4.2 2 2 2 4 4 4 4 Nucleoporin Nup120/160 zf-B_box PF00643.24 EFA77798.1 - 3.3e-05 23.9 5.2 9e-05 22.6 5.2 1.7 1 0 0 1 1 1 1 B-box zinc finger PQQ_3 PF13570.6 EFA77798.1 - 0.028 14.9 0.0 10 6.8 0.0 4.0 3 1 1 4 4 4 0 PQQ-like domain PALB2_WD40 PF16756.5 EFA77798.1 - 0.046 12.7 0.2 1.7 7.5 0.0 2.2 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain zf_PR_Knuckle PF18445.1 EFA77798.1 - 0.3 10.9 2.2 0.6 10.0 2.2 1.5 1 0 0 1 1 1 0 PR zinc knuckle motif Mucin PF01456.17 EFA77799.1 - 0.011 15.7 15.8 0.013 15.5 15.8 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EFA77799.1 - 0.042 13.8 8.5 0.056 13.4 8.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ELMO_CED12 PF04727.13 EFA77800.1 - 2.9e-44 151.3 2.1 5.5e-44 150.4 2.1 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family CUE PF02845.16 EFA77801.1 - 4.7e-05 23.0 0.1 0.00013 21.6 0.1 1.8 1 0 0 1 1 1 1 CUE domain CENP-U PF13097.6 EFA77801.1 - 0.0019 18.2 0.4 0.0019 18.2 0.4 3.0 2 1 0 3 3 3 1 CENP-A nucleosome associated complex (NAC) subunit AAA_18 PF13238.6 EFA77801.1 - 0.17 12.4 7.6 0.3 11.6 7.6 1.4 1 0 0 1 1 1 0 AAA domain Med9 PF07544.13 EFA77801.1 - 0.36 10.9 13.4 0.23 11.6 2.1 3.5 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 MCR_C PF04609.12 EFA77801.1 - 1 8.4 5.6 0.24 10.4 0.5 2.4 3 1 0 3 3 3 0 Methyl-coenzyme M reductase operon protein C KxDL PF10241.9 EFA77801.1 - 2.3 8.5 8.7 1.1 9.6 0.9 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein Serine_rich PF08824.10 EFA77801.1 - 4.1 7.4 9.7 0.28 11.2 3.0 2.3 3 0 0 3 3 3 0 Serine rich protein interaction domain NOA36 PF06524.12 EFA77801.1 - 5.2 6.3 6.6 9.3 5.5 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein Noelin-1 PF12308.8 EFA77801.1 - 6.3 6.9 7.8 24 5.0 0.1 3.1 2 1 1 3 3 3 0 Neurogenesis glycoprotein MitMem_reg PF13012.6 EFA77801.1 - 7.4 7.0 9.5 1.2e+03 -0.1 9.5 3.0 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function 4HBT PF03061.22 EFA77802.1 - 0.028 14.7 0.1 0.052 13.9 0.0 1.5 2 0 0 2 2 2 0 Thioesterase superfamily Pkinase_Tyr PF07714.17 EFA77803.1 - 1e-75 254.4 3.6 6e-40 137.2 0.2 3.5 3 1 1 4 4 4 3 Protein tyrosine kinase Pkinase PF00069.25 EFA77803.1 - 2.9e-58 197.3 10.9 1.4e-27 96.7 1.8 4.1 3 1 1 4 4 4 3 Protein kinase domain FHA_2 PF17913.1 EFA77803.1 - 1.1e-05 25.6 0.4 0.00024 21.3 0.0 3.2 3 0 0 3 3 3 1 FHA domain FHA PF00498.26 EFA77803.1 - 0.00072 19.8 0.3 0.00072 19.8 0.3 3.1 2 1 0 2 2 2 1 FHA domain Peptidase_S24 PF00717.23 EFA77804.1 - 1.1e-09 38.1 0.1 2.4e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EFA77804.1 - 0.0053 16.5 0.0 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Orf78 PF06024.12 EFA77804.1 - 0.042 14.2 3.4 0.078 13.3 3.4 1.5 1 1 0 1 1 1 0 Orf78 (ac78) CSG2 PF16965.5 EFA77804.1 - 0.05 12.5 1.8 0.061 12.3 1.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Peroxin-13_N PF04088.13 EFA77804.1 - 0.079 13.2 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF2951 PF11166.8 EFA77804.1 - 0.084 13.1 3.0 0.14 12.4 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) PBP_sp32 PF07222.12 EFA77804.1 - 0.092 12.2 5.6 0.14 11.6 5.6 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 GCD14 PF08704.10 EFA77804.1 - 0.15 11.7 5.1 0.23 11.1 5.1 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Presenilin PF01080.17 EFA77804.1 - 0.27 9.9 1.2 0.34 9.6 1.2 1.1 1 0 0 1 1 1 0 Presenilin Ureide_permease PF07168.11 EFA77804.1 - 0.31 9.8 2.1 0.37 9.5 2.1 1.1 1 0 0 1 1 1 0 Ureide permease DUF2722 PF10846.8 EFA77804.1 - 0.49 9.3 11.0 0.7 8.8 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Zip PF02535.22 EFA77804.1 - 1 8.5 2.0 1.2 8.2 2.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3899 PF13038.6 EFA77804.1 - 1.6 9.3 5.4 6.9 7.2 5.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) Nucleoporin_FG2 PF15967.5 EFA77804.1 - 2.7 6.4 4.7 3.8 5.9 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region TTL PF03133.15 EFA77805.1 - 2.7e-55 187.6 1.3 6.4e-55 186.4 1.3 1.6 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Peptidase_C78 PF07910.13 EFA77805.1 - 1.8e-44 151.8 0.4 6.4e-44 150.0 0.4 2.0 1 1 0 1 1 1 1 Peptidase family C78 ATP-grasp_3 PF02655.14 EFA77805.1 - 0.065 13.3 0.0 1 9.4 0.0 2.5 2 0 0 2 2 2 0 ATP-grasp domain PAPS_reduct PF01507.19 EFA77806.1 - 1e-29 103.8 0.1 6e-20 72.0 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family ABC2_membrane PF01061.24 EFA77807.1 - 1.6e-32 112.7 15.1 2.4e-32 112.0 15.1 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFA77807.1 - 5.7e-28 98.1 0.1 3.7e-27 95.5 0.0 2.5 2 0 0 2 2 2 1 ABC transporter ResIII PF04851.15 EFA77807.1 - 5.5e-14 52.5 0.5 1e-12 48.4 0.0 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EFA77807.1 - 2.4e-07 30.1 0.7 6.9e-06 25.3 0.3 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 EFA77807.1 - 1.1e-06 29.0 0.1 0.022 15.1 0.0 3.2 3 0 0 3 3 3 2 AAA domain DEAD PF00270.29 EFA77807.1 - 1.2e-06 28.4 0.3 0.00016 21.5 0.2 3.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EFA77807.1 - 2.6e-06 27.8 0.6 0.051 13.9 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFA77807.1 - 6.4e-06 26.0 0.0 0.076 12.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain SWI2_SNF2 PF18766.1 EFA77807.1 - 2.9e-05 23.9 0.1 8.8e-05 22.3 0.1 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase RsgA_GTPase PF03193.16 EFA77807.1 - 0.00011 22.2 0.7 0.00051 20.0 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase DUF2075 PF09848.9 EFA77807.1 - 0.0004 19.7 0.0 0.19 11.0 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EFA77807.1 - 0.001 19.5 0.0 0.98 9.9 0.0 3.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA77807.1 - 0.0018 18.7 0.1 0.018 15.4 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain DUF853 PF05872.12 EFA77807.1 - 0.0047 15.6 0.2 0.066 11.8 0.1 2.2 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) cobW PF02492.19 EFA77807.1 - 0.0061 16.2 0.1 0.4 10.2 0.0 3.1 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.12 EFA77807.1 - 0.0084 15.6 0.4 1.7 8.0 0.1 2.7 2 0 0 2 2 2 1 Poxvirus A32 protein ATP-synt_ab PF00006.25 EFA77807.1 - 0.017 14.8 0.0 5 6.7 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.15 EFA77807.1 - 0.026 14.4 1.5 0.49 10.3 0.1 3.3 3 1 0 3 3 3 0 NTPase AAA_29 PF13555.6 EFA77807.1 - 0.027 14.2 0.7 0.077 12.7 0.2 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EFA77807.1 - 0.035 13.9 4.5 5.7 6.6 0.0 3.5 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 EFA77807.1 - 0.049 13.6 3.7 0.33 10.9 0.1 2.7 3 0 0 3 3 2 0 NACHT domain AAA_24 PF13479.6 EFA77807.1 - 0.071 12.8 0.2 0.85 9.3 0.2 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFA77807.1 - 0.084 13.0 0.1 0.31 11.1 0.1 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 EFA77807.1 - 0.11 12.7 0.7 0.55 10.5 0.4 2.1 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA77807.1 - 0.31 10.4 1.1 3 7.1 0.2 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family MobB PF03205.14 EFA77807.1 - 0.58 10.1 4.4 1.3 8.9 0.1 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AATF-Che1 PF13339.6 EFA77807.1 - 2.9 8.6 8.9 14 6.4 2.8 2.5 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor CbiA PF01656.23 EFA77807.1 - 2.9 7.9 6.0 24 5.0 0.2 3.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain UPF0240 PF06784.11 EFA77808.1 - 1.4e-06 28.5 0.1 9.2e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0240) MRP-L20 PF12824.7 EFA77808.1 - 3.9e-06 27.1 0.1 7.6e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Coiled PF05710.12 EFA77809.1 - 0.0028 18.4 3.8 0.0032 18.2 3.8 1.1 1 0 0 1 1 1 1 Coiled coil TrmO PF01980.16 EFA77809.1 - 0.074 13.3 0.0 0.074 13.3 0.0 1.1 1 0 0 1 1 1 0 tRNA-methyltransferase O Coiled PF05710.12 EFA77810.1 - 9.4e-06 26.4 4.3 1e-05 26.3 4.3 1.2 1 0 0 1 1 1 1 Coiled coil GPHR_N PF12537.8 EFA77810.1 - 0.017 15.2 1.0 0.02 15.0 1.0 1.2 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Coiled PF05710.12 EFA77811.1 - 0.003 18.3 9.5 0.0038 18.0 9.5 1.3 1 1 0 1 1 1 1 Coiled coil GPHR_N PF12537.8 EFA77811.1 - 0.078 13.1 1.1 0.087 12.9 1.1 1.3 1 1 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal PIH1 PF08190.12 EFA77812.1 - 4.5e-13 49.0 2.0 4.5e-13 49.0 2.0 2.1 3 0 0 3 3 3 1 PIH1 N-terminal domain PIH1_CS PF18201.1 EFA77812.1 - 7.7e-12 45.5 0.4 2.7e-11 43.7 0.4 2.0 1 0 0 1 1 1 1 PIH1 CS-like domain EVI2A PF05399.11 EFA77812.1 - 0.68 9.5 8.2 0.16 11.5 3.8 2.1 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Zip PF02535.22 EFA77812.1 - 5.2 6.2 6.3 3.5 6.8 0.8 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter WD40 PF00400.32 EFA77813.1 - 3.1e-26 91.1 6.7 7.2e-06 26.7 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA77813.1 - 8.8e-09 35.6 1.5 0.33 11.3 0.0 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA77813.1 - 2.6e-05 23.3 0.4 0.029 13.3 0.1 2.7 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFA77813.1 - 0.028 13.1 1.9 0.84 8.2 0.1 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFA77813.1 - 0.07 11.9 1.2 0.24 10.1 0.1 2.1 2 1 0 2 2 2 0 Nup133 N terminal like BBS2_Mid PF14783.6 EFA77813.1 - 0.11 12.6 0.0 0.49 10.5 0.0 2.1 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF5620 PF18522.1 EFA77813.1 - 0.11 12.9 0.0 0.11 12.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5620) Chordopox_G3 PF06129.12 EFA77814.1 - 0.42 11.3 3.9 0.71 10.6 3.9 1.4 1 0 0 1 1 1 0 Chordopoxvirus G3 protein COMM_domain PF07258.14 EFA77815.1 - 2e-16 59.9 0.1 4.3e-16 58.8 0.1 1.6 1 0 0 1 1 1 1 COMM domain HHH_4 PF14490.6 EFA77815.1 - 0.0078 16.2 0.1 3 7.9 0.1 2.4 1 1 1 2 2 2 2 Helix-hairpin-helix containing domain FERM_C PF09380.10 EFA77816.1 - 0.0045 17.3 0.3 0.0058 17.0 0.3 1.3 1 0 0 1 1 1 1 FERM C-terminal PH-like domain Transposase_22 PF02994.14 EFA77816.1 - 0.067 13.4 0.3 0.096 12.9 0.3 1.3 1 0 0 1 1 1 0 L1 transposable element RBD-like domain TAL_FSA PF00923.19 EFA77817.1 - 5.7e-92 308.1 0.3 6.5e-92 307.9 0.3 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Profilin PF00235.19 EFA77818.1 - 0.00015 22.0 0.0 0.00021 21.5 0.0 1.2 1 0 0 1 1 1 1 Profilin Ras PF00071.22 EFA77820.1 - 2e-65 219.3 0.1 2.4e-65 219.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA77820.1 - 3.1e-35 121.0 0.0 4.7e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA77820.1 - 3.6e-15 55.9 0.1 4.6e-15 55.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA77820.1 - 1.3e-05 24.9 0.1 4.3e-05 23.1 0.0 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA77820.1 - 3.6e-05 23.2 0.0 4.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA77820.1 - 0.00014 21.9 0.0 0.00032 20.7 0.0 1.6 1 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA77820.1 - 0.00073 19.5 0.2 0.24 11.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase DUF3963 PF13124.6 EFA77820.1 - 0.0077 16.2 0.2 0.02 14.9 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3963) SRPRB PF09439.10 EFA77820.1 - 0.0088 15.5 0.0 0.014 14.8 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MCM PF00493.23 EFA77820.1 - 0.03 13.4 0.0 0.18 10.9 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain AAA_29 PF13555.6 EFA77820.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA77820.1 - 0.06 13.7 0.0 0.077 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EFA77820.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GAS PF13851.6 EFA77821.1 - 8.4e-05 22.0 55.7 0.00046 19.6 23.1 7.9 4 1 4 8 8 8 4 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 EFA77821.1 - 0.011 15.7 13.7 0.011 15.7 13.7 11.4 5 3 8 13 13 13 0 TATA element modulatory factor 1 DNA binding Josephin PF02099.17 EFA77822.1 - 8.8e-51 172.2 0.2 1.2e-50 171.8 0.2 1.2 1 0 0 1 1 1 1 Josephin UIM PF02809.20 EFA77822.1 - 4.8e-05 23.0 3.1 0.0059 16.4 1.2 2.8 2 0 0 2 2 2 2 Ubiquitin interaction motif Arginase PF00491.21 EFA77823.1 - 7e-57 193.1 0.0 8.4e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family DUF1743 PF08489.11 EFA77823.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) Cytokin_check_N PF10407.9 EFA77824.1 - 0.018 15.0 0.6 0.035 14.1 0.6 1.6 1 1 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Yuri_gagarin PF15934.5 EFA77824.1 - 0.023 14.6 3.7 0.025 14.4 3.7 1.2 1 0 0 1 1 1 0 Yuri gagarin Speriolin_N PF15058.6 EFA77824.1 - 0.099 12.7 0.1 0.13 12.4 0.1 1.1 1 0 0 1 1 1 0 Speriolin N terminus Laps PF10169.9 EFA77824.1 - 0.14 12.7 0.2 0.14 12.7 0.2 1.9 1 1 1 2 2 2 0 Learning-associated protein DHHC PF01529.20 EFA77825.1 - 2.8e-26 92.2 21.9 5.3e-26 91.3 7.8 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase AAR2 PF05282.11 EFA77825.1 - 0.0027 17.2 0.0 0.0031 17.0 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein zf-AD PF07776.15 EFA77825.1 - 0.017 15.3 6.0 0.032 14.5 6.0 1.5 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) FAM176 PF14851.6 EFA77825.1 - 0.019 14.7 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 FAM176 family DUF1272 PF06906.11 EFA77825.1 - 0.081 13.0 7.8 0.27 11.4 7.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) Menin PF05053.13 EFA77825.1 - 0.14 10.5 3.4 0.17 10.3 3.4 1.1 1 0 0 1 1 1 0 Menin DUF2321 PF10083.9 EFA77825.1 - 0.37 10.4 6.5 0.55 9.9 6.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Secretin_N_2 PF07655.13 EFA77825.1 - 0.58 10.7 13.6 0.89 10.1 13.6 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4834 PF16118.5 EFA77825.1 - 2.8 9.0 12.9 32 5.6 12.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4291 PF14124.6 EFA77827.1 - 2.8e-72 242.4 0.9 3.2e-72 242.2 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) CactinC_cactus PF09732.9 EFA77828.1 - 1.3e-58 196.3 8.9 3.1e-58 195.2 8.9 1.7 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 EFA77828.1 - 6.6e-48 163.1 3.5 6.6e-48 163.1 3.5 3.4 4 0 0 4 4 4 1 Conserved mid region of cactin FapA PF03961.13 EFA77829.1 - 3.4 6.2 13.4 0.17 10.5 4.4 2.7 3 0 0 3 3 3 0 Flagellar Assembly Protein A Usp PF00582.26 EFA77830.1 - 1.2e-19 71.2 0.0 1.5e-19 70.9 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family DUF4598 PF15370.6 EFA77831.1 - 4.5e-17 62.5 19.5 2.5e-16 60.1 19.5 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4598) SUIM_assoc PF16619.5 EFA77831.1 - 0.0011 19.0 11.6 0.0027 17.7 11.6 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF5321 PF17254.2 EFA77831.1 - 0.041 13.3 7.1 0.078 12.4 7.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5321) SLC12 PF03522.15 EFA77831.1 - 0.16 10.9 18.6 0.093 11.7 17.1 1.3 1 1 0 1 1 1 0 Solute carrier family 12 Roughex PF06020.11 EFA77831.1 - 0.18 10.9 5.6 0.26 10.3 5.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein OAD_gamma PF04277.13 EFA77831.1 - 0.52 11.0 1.6 1.4 9.5 1.6 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Lin-8 PF03353.15 EFA77831.1 - 0.8 9.2 14.4 1.1 8.7 14.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ALMT PF11744.8 EFA77831.1 - 5.1 5.8 12.9 6 5.6 12.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter MFS_1 PF07690.16 EFA77832.1 - 9.2e-30 103.7 36.3 7.8e-16 57.9 19.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA77832.1 - 0.00013 21.0 5.8 0.00013 21.0 5.8 3.2 3 1 0 3 3 3 1 Sugar (and other) transporter Ninjurin PF04923.12 EFA77832.1 - 5.4 7.0 6.7 0.86 9.6 0.3 2.7 3 0 0 3 3 3 0 Ninjurin DUF5050 PF16472.5 EFA77833.1 - 0.016 14.5 2.1 0.039 13.2 2.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5050) Sporozoite_P67 PF05642.11 EFA77833.1 - 0.47 8.5 4.2 0.56 8.2 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cyclin_N PF00134.23 EFA77834.1 - 3.4e-13 49.5 0.9 4.3e-09 36.2 0.2 2.5 2 1 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFA77834.1 - 0.0002 21.4 2.4 0.00023 21.2 0.1 2.0 1 1 1 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EFA77834.1 - 0.0018 18.3 0.1 0.053 13.6 0.0 2.5 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 EFA77834.1 - 0.0068 16.8 0.1 0.012 16.0 0.1 1.6 1 0 0 1 1 1 1 Cyclin C-terminal domain ATG101 PF07855.12 EFA77834.1 - 0.027 14.5 0.1 0.044 13.8 0.1 1.4 1 0 0 1 1 1 0 Autophagy-related protein 101 SnoaL_2 PF12680.7 EFA77835.1 - 0.0041 17.7 0.0 0.0055 17.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain RGI1 PF10843.8 EFA77835.1 - 0.022 14.4 0.2 0.028 14.1 0.2 1.1 1 0 0 1 1 1 0 Respiratory growth induced protein 1 Alpha-amylase PF00128.24 EFA77836.1 - 2.7e-15 56.8 0.0 1e-14 54.9 0.0 1.9 1 1 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EFA77836.1 - 0.0003 20.0 0.0 0.00049 19.3 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain LBP_C PF17386.2 EFA77836.1 - 0.093 12.6 0.0 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase C-terminal domain MMR_HSR1 PF01926.23 EFA77837.1 - 1e-09 38.5 0.0 2.2e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA77837.1 - 5.7e-06 26.3 1.5 0.00017 21.5 0.5 2.4 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFA77837.1 - 4.5e-05 23.1 0.4 0.29 10.7 0.0 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFA77837.1 - 0.00018 21.0 0.0 0.00034 20.1 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFA77837.1 - 0.0015 18.3 0.0 0.0043 16.8 0.0 1.7 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 EFA77837.1 - 0.0049 16.8 1.0 0.0094 15.9 0.5 1.8 2 0 0 2 2 2 1 NTPase AAA_18 PF13238.6 EFA77837.1 - 0.0089 16.6 0.1 0.017 15.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EFA77837.1 - 0.016 14.8 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B TsaE PF02367.17 EFA77837.1 - 0.017 15.1 0.4 0.07 13.1 0.2 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EFA77837.1 - 0.019 15.2 0.0 0.068 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EFA77837.1 - 0.029 14.1 2.9 5.6 6.7 0.8 3.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 EFA77837.1 - 0.038 13.6 0.8 0.15 11.6 0.3 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EFA77837.1 - 0.041 13.9 1.9 2.2 8.3 0.8 2.4 1 1 1 2 2 2 0 Dynamin family AAA_28 PF13521.6 EFA77837.1 - 0.068 13.4 1.5 0.14 12.4 1.5 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFA77837.1 - 0.073 12.8 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 EFA77837.1 - 0.076 12.0 0.2 0.14 11.1 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EFA77837.1 - 0.094 13.1 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain Arf PF00025.21 EFA77837.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family UPF0547 PF10571.9 EFA77837.1 - 0.37 10.9 0.0 0.37 10.9 0.0 2.0 2 0 0 2 2 1 0 Uncharacterised protein family UPF0547 zf-ribbon_3 PF13248.6 EFA77837.1 - 0.55 9.7 5.0 2.6 7.6 0.2 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Med7 PF05983.11 EFA77839.1 - 0.11 12.6 4.3 0.24 11.5 4.3 1.6 1 0 0 1 1 1 0 MED7 protein HTH_6 PF01418.17 EFA77839.1 - 0.94 9.5 8.9 2.7 8.1 0.1 3.5 3 1 0 3 3 3 0 Helix-turn-helix domain, rpiR family DUF2203 PF09969.9 EFA77839.1 - 1.9 9.3 5.6 6.8 7.4 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Kelch_6 PF13964.6 EFA77840.1 - 4.8e-13 48.9 6.4 3.3e-07 30.3 0.0 5.1 3 1 2 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA77840.1 - 6.6e-08 32.6 7.5 1.6e-07 31.4 7.5 1.6 1 0 0 1 1 1 1 B-box zinc finger Mitofilin PF09731.9 EFA77840.1 - 0.011 14.7 4.0 0.016 14.1 4.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF5074 PF16819.5 EFA77840.1 - 0.023 14.7 10.3 0.77 9.8 1.5 4.3 1 1 3 4 4 4 0 Domain of unknown function (DUF5074) Kelch_1 PF01344.25 EFA77840.1 - 0.12 12.0 3.8 1.1 8.9 0.1 3.5 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 EFA77840.1 - 9.9 6.6 8.0 7.3 7.0 0.0 3.7 6 0 0 6 6 6 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA77841.1 - 7.3e-10 38.9 3.4 1.5e-09 37.9 3.4 1.4 1 0 0 1 1 1 1 B-box zinc finger zf-B_box PF00643.24 EFA77842.1 - 1.9e-09 37.5 3.4 3.5e-09 36.7 3.4 1.4 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA77842.1 - 1.3e-06 28.3 1.2 0.0013 18.7 0.1 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA77842.1 - 4.3e-06 26.8 0.7 0.019 15.3 0.1 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 EFA77842.1 - 2.9e-05 23.5 0.1 0.15 11.7 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EFA77842.1 - 0.2 11.7 0.5 17 5.6 0.0 2.6 2 0 0 2 2 2 0 Kelch motif Thy1 PF02511.15 EFA77844.1 - 2.8e-51 174.0 0.2 3.8e-51 173.6 0.2 1.1 1 0 0 1 1 1 1 Thymidylate synthase complementing protein Kelch_6 PF13964.6 EFA77845.1 - 3.5e-18 65.2 3.3 7.4e-06 26.1 0.0 5.9 3 1 3 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFA77845.1 - 1.9e-14 52.9 8.5 0.00011 21.7 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EFA77845.1 - 4.3e-09 36.2 6.4 0.00063 19.7 0.1 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA77845.1 - 1.7e-05 24.6 3.7 0.046 13.7 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFA77845.1 - 0.0021 18.0 1.9 0.8 9.8 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 EFA77845.1 - 0.0036 17.6 1.5 1.5 9.2 0.0 4.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Cupin_2 PF07883.11 EFA77846.1 - 1.5e-07 31.0 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EFA77846.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) DUF4437 PF14499.6 EFA77846.1 - 0.024 13.8 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4437) OGG_N PF07934.12 EFA77846.1 - 0.035 14.2 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain Ppnp PF06865.11 EFA77846.1 - 0.044 14.2 0.0 0.055 13.9 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine/purine nucleoside phosphorylase LON_substr_bdg PF02190.16 EFA77846.1 - 0.072 13.0 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain 7TM_GPCR_Srd PF10317.9 EFA77847.1 - 0.87 8.7 4.9 0.36 10.0 1.9 1.8 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srd DUF3399 PF11879.8 EFA77848.1 - 0.18 12.1 4.3 0.97 9.8 4.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3399) DUF3381 PF11861.8 EFA77848.1 - 0.44 10.3 2.6 0.53 10.1 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Profilin PF00235.19 EFA77849.1 - 9.5e-35 119.6 0.0 1.1e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Profilin EFP_N PF08207.12 EFA77849.1 - 0.063 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Profilin PF00235.19 EFA77850.1 - 1.7e-43 147.9 0.4 1.9e-43 147.8 0.4 1.0 1 0 0 1 1 1 1 Profilin Methyltransf_16 PF10294.9 EFA77851.1 - 2.5e-20 72.9 0.0 4.5e-20 72.1 0.0 1.3 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFA77851.1 - 0.0007 19.5 0.0 0.00097 19.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EFA77851.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 EFA77851.1 - 0.082 12.5 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 EFA77851.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Laminin_EGF PF00053.24 EFA77852.1 - 7.4e-07 29.2 95.9 0.0068 16.5 15.0 6.4 3 1 3 6 6 6 3 Laminin EGF domain EGF PF00008.27 EFA77852.1 - 0.0036 17.6 4.6 0.0036 17.6 4.6 6.6 7 1 1 8 8 8 3 EGF-like domain SPT_ssu-like PF11779.8 EFA77852.1 - 0.041 13.5 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like Y_Y_Y PF07495.13 EFA77852.1 - 0.048 13.6 13.9 37 4.4 0.0 9.4 12 0 0 12 12 12 0 Y_Y_Y domain EGF_2 PF07974.13 EFA77852.1 - 8.1 6.9 101.8 0.013 15.8 10.7 7.0 7 1 1 8 8 8 0 EGF-like domain Complex1_51K PF01512.17 EFA77854.1 - 5e-49 166.1 0.0 7.8e-49 165.4 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EFA77854.1 - 2.5e-28 98.0 0.0 5.3e-28 96.9 0.0 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EFA77854.1 - 1.8e-08 34.1 0.2 1.5e-07 31.2 0.0 2.5 2 1 1 3 3 3 1 SLBB domain ABC_tran PF00005.27 EFA77855.1 - 5.4e-28 98.2 1.6 6.6e-28 97.9 0.1 1.9 2 0 0 2 2 2 1 ABC transporter ABC2_membrane PF01061.24 EFA77855.1 - 1.6e-17 63.7 9.1 3.4e-13 49.5 3.2 2.2 1 1 1 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.6 EFA77855.1 - 2.7e-09 37.3 0.0 6.5e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFA77855.1 - 9.7e-05 22.8 0.0 0.00018 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFA77855.1 - 0.0001 22.0 0.2 0.00026 20.7 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA77855.1 - 0.00031 21.0 0.3 0.0052 17.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFA77855.1 - 0.00034 20.6 0.1 0.00091 19.2 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase Rad17 PF03215.15 EFA77855.1 - 0.0006 19.8 0.1 0.0015 18.5 0.1 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain SMC_N PF02463.19 EFA77855.1 - 0.0016 17.9 0.0 0.012 15.1 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EFA77855.1 - 0.005 16.4 0.1 0.012 15.2 0.1 1.5 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EFA77855.1 - 0.0052 16.7 0.2 4.6 7.1 0.1 3.0 3 0 0 3 3 3 1 NTPase RNA_helicase PF00910.22 EFA77855.1 - 0.0082 16.5 0.3 0.73 10.3 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_24 PF13479.6 EFA77855.1 - 0.0086 15.8 0.1 0.061 13.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFA77855.1 - 0.016 15.2 1.1 0.028 14.4 0.1 2.0 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 EFA77855.1 - 0.023 13.8 0.3 0.045 12.8 0.3 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 EFA77855.1 - 0.025 15.1 0.0 0.06 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFA77855.1 - 0.038 14.0 0.2 0.083 12.9 0.2 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EFA77855.1 - 0.038 13.7 0.1 0.067 12.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EFA77855.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_23 PF13476.6 EFA77855.1 - 0.071 13.6 0.1 0.071 13.6 0.1 2.8 2 1 1 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EFA77855.1 - 0.076 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 EFA77855.1 - 0.084 13.3 0.2 0.56 10.6 0.2 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFA77855.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFA77855.1 - 0.28 11.5 1.0 0.8 10.0 1.0 1.9 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 EFA77855.1 - 0.59 10.2 3.7 1.5 8.8 0.3 2.8 2 1 2 4 4 4 0 Helicase HerA, central domain DUF3449 PF11931.8 EFA77856.1 - 1.6e-64 217.1 4.4 1.6e-64 217.1 4.4 3.3 3 1 0 3 3 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EFA77856.1 - 2.4e-21 76.0 8.2 2.4e-21 76.0 8.2 2.1 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EFA77856.1 - 8.5e-12 44.7 0.3 2.3e-11 43.4 0.3 1.8 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 EFA77856.1 - 5e-11 42.6 7.7 2.2e-08 34.2 2.1 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFA77856.1 - 6.5e-09 35.9 0.8 6.5e-09 35.9 0.8 2.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFA77856.1 - 6.2e-05 23.3 2.1 0.02 15.2 0.2 3.1 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EFA77856.1 - 0.0069 17.1 1.8 2.9 8.9 0.1 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger Menin PF05053.13 EFA77856.1 - 0.097 11.0 9.3 0.14 10.5 9.3 1.2 1 0 0 1 1 1 0 Menin Desulfoferrod_N PF06397.12 EFA77856.1 - 0.18 11.4 0.6 0.37 10.4 0.6 1.4 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain DUF5423 PF17461.2 EFA77856.1 - 0.64 8.8 3.3 1.1 8.1 3.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Presenilin PF01080.17 EFA77856.1 - 4 6.1 9.5 6.1 5.5 9.5 1.4 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFA77856.1 - 6 6.0 5.3 9.9 5.3 5.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter T4SS_TraI PF16932.5 EFA77857.1 - 0.021 14.0 1.6 0.042 13.0 0.7 1.7 1 1 1 2 2 2 0 Type IV secretory system, conjugal DNA-protein transfer Cep57_CLD PF14073.6 EFA77857.1 - 0.093 12.7 8.2 0.048 13.7 4.9 1.9 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 zf-B_box PF00643.24 EFA77858.1 - 4.4e-05 23.5 6.0 4.4e-05 23.5 6.0 2.3 2 0 0 2 2 2 1 B-box zinc finger DUF1122 PF06557.11 EFA77858.1 - 0.066 12.6 0.7 0.13 11.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1122) zf-B_box PF00643.24 EFA77859.1 - 3.4e-05 23.9 7.4 3.4e-05 23.9 7.4 1.8 2 0 0 2 2 2 1 B-box zinc finger Kelch_6 PF13964.6 EFA77859.1 - 0.0012 19.1 0.2 0.0012 19.1 0.2 3.5 5 0 0 5 5 5 1 Kelch motif Cep57_CLD PF14073.6 EFA77859.1 - 0.017 15.2 2.3 0.017 15.2 2.3 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 DUF960 PF06124.11 EFA77859.1 - 0.03 15.0 1.5 0.24 12.1 1.5 2.7 1 0 0 1 1 1 0 Staphylococcal protein of unknown function (DUF960) Complex1_LYR_2 PF13233.6 EFA77859.1 - 1.1 10.1 4.5 2.4 8.9 0.1 3.1 2 1 1 3 3 3 0 Complex1_LYR-like DUF4047 PF13256.6 EFA77859.1 - 1.4 9.2 7.6 6.6 6.9 4.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) APG6_N PF17675.1 EFA77859.1 - 3.5 8.2 9.3 0.16 12.5 1.4 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region MAP65_ASE1 PF03999.12 EFA77864.1 - 4.2e-64 217.3 42.0 1.8e-63 215.3 42.0 1.9 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Rnk_N PF14760.6 EFA77864.1 - 1.7 9.2 5.7 7.9 7.1 5.7 2.2 1 0 0 1 1 1 0 Rnk N-terminus DBR1 PF05011.13 EFA77865.1 - 6.5e-22 78.4 9.8 6.5e-22 78.4 9.8 2.3 2 1 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Pep1_7 PF17232.2 EFA77865.1 - 6.2 7.4 7.9 35 5.0 0.1 3.4 3 0 0 3 3 3 0 Elicitor peptide 1-7 Kelch_6 PF13964.6 EFA77866.1 - 1.2e-11 44.4 7.5 0.0001 22.5 0.2 5.6 5 1 0 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA77866.1 - 2.6e-07 30.7 5.6 5.3e-07 29.7 5.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA77866.1 - 0.00059 20.0 0.0 2 8.8 0.0 3.0 3 0 0 3 3 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA77866.1 - 0.027 14.4 3.9 0.19 11.7 0.1 3.4 3 0 0 3 3 3 0 Kelch motif EPO_TPO PF00758.18 EFA77866.1 - 0.031 14.3 1.8 0.067 13.2 1.8 1.5 1 0 0 1 1 1 0 Erythropoietin/thrombopoietin DUF2459 PF09601.10 EFA77866.1 - 0.079 12.8 4.3 0.033 14.0 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2459) ATP-grasp PF02222.22 EFA77866.1 - 0.09 12.3 0.1 12 5.5 0.0 2.7 2 0 0 2 2 2 0 ATP-grasp domain DUF5074 PF16819.5 EFA77866.1 - 0.1 12.6 20.3 0.15 12.1 0.4 5.2 3 1 2 5 5 5 0 Domain of unknown function (DUF5074) Kelch_4 PF13418.6 EFA77866.1 - 0.11 12.5 4.0 9.7 6.3 0.1 4.5 4 1 0 4 4 4 0 Galactose oxidase, central domain CE2_N PF17996.1 EFA77866.1 - 0.14 12.1 5.1 4.5 7.3 0.4 3.0 2 1 0 2 2 2 0 Carbohydrate esterase 2 N-terminal Phasin PF05597.11 EFA77866.1 - 0.9 9.6 7.1 3.4 7.7 1.6 2.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ATP_Ca_trans_C PF12424.8 EFA77866.1 - 8 7.0 9.5 6.8 7.3 1.0 3.4 3 0 0 3 3 3 0 Plasma membrane calcium transporter ATPase C terminal tRNA_m1G_MT PF01746.21 EFA77867.1 - 2e-28 99.4 8.1 1e-24 87.3 0.1 3.0 2 1 1 3 3 3 2 tRNA (Guanine-1)-methyltransferase FA_hydroxylase PF04116.13 EFA77868.1 - 1e-14 55.0 11.5 2.7e-08 34.2 0.1 4.2 4 3 1 5 5 5 2 Fatty acid hydroxylase superfamily Snf7 PF03357.21 EFA77869.1 - 3e-28 98.6 22.6 3e-28 98.6 22.6 3.2 2 1 1 3 3 3 1 Snf7 Phage_int_SAM_6 PF18644.1 EFA77869.1 - 0.054 13.5 4.2 0.13 12.3 1.3 2.8 3 1 0 3 3 3 0 Phage integrase SAM-like domain Asparaginase_2 PF01112.18 EFA77869.1 - 0.45 9.5 2.9 0.76 8.7 2.9 1.3 1 0 0 1 1 1 0 Asparaginase DUF1013 PF06242.11 EFA77869.1 - 1.9 8.5 11.9 0.067 13.2 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1013) RasGEF PF00617.19 EFA77870.1 - 5.7e-28 98.3 10.6 2.7e-21 76.6 2.0 3.3 2 1 1 3 3 3 2 RasGEF domain RasGEF_N PF00618.20 EFA77870.1 - 1.5e-20 73.4 0.2 1.5e-20 73.4 0.2 3.6 3 1 1 4 4 4 1 RasGEF N-terminal motif IQ PF00612.27 EFA77870.1 - 0.051 13.4 16.5 0.078 12.8 5.7 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif CTNNB1_binding PF08347.11 EFA77870.1 - 2.6 8.2 13.7 1.4 9.1 10.6 2.0 2 0 0 2 2 2 0 N-terminal CTNNB1 binding Glyoxalase PF00903.25 EFA77871.1 - 2.7e-15 56.7 0.0 3e-15 56.5 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFA77871.1 - 0.0015 18.7 0.0 0.0027 17.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EFA77871.1 - 0.0097 16.7 0.0 0.014 16.1 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EFA77871.1 - 0.02 14.8 0.1 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain FNIP PF05725.12 EFA77872.1 - 7.7e-16 58.0 0.7 1.3e-08 34.8 0.0 2.6 1 1 1 2 2 2 2 FNIP Repeat DUF1769 PF08588.10 EFA77872.1 - 0.025 14.8 0.4 3.6 7.9 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1769) FTH PF01827.27 EFA77874.1 - 0.0097 15.7 0.2 0.0097 15.7 0.2 3.1 2 1 1 3 3 3 2 FTH domain F-box_4 PF15966.5 EFA77874.1 - 0.087 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 F-box EBV-NA3 PF05009.12 EFA77874.1 - 0.31 10.6 1.7 11 5.4 0.0 2.4 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) KH_7 PF17214.3 EFA77875.1 - 0.0097 15.9 0.1 0.028 14.4 0.1 1.7 1 0 0 1 1 1 1 KH domain Peptidase_M8 PF01457.16 EFA77876.1 - 9.2e-47 159.9 4.7 9.2e-47 159.9 4.7 1.5 2 0 0 2 2 2 1 Leishmanolysin NusB PF01029.18 EFA77877.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 NusB family ENOD93 PF03386.14 EFA77877.1 - 0.22 11.4 0.8 0.61 10.0 0.2 2.0 2 0 0 2 2 2 0 Early nodulin 93 ENOD93 protein Prefoldin PF02996.17 EFA77878.1 - 7.1e-21 74.3 2.3 7.1e-21 74.3 2.3 2.3 2 1 1 3 3 3 1 Prefoldin subunit Prefoldin_3 PF13758.6 EFA77878.1 - 4e-08 33.2 0.4 4e-08 33.2 0.4 3.7 2 1 1 3 3 3 1 Prefoldin subunit DUF3835 PF12927.7 EFA77878.1 - 0.0016 19.3 0.6 0.0016 19.3 0.6 4.9 3 1 4 7 7 7 1 Domain of unknown function (DUF3835) Methyltransf_4 PF02390.17 EFA77879.1 - 1.8e-50 170.8 0.7 2.9e-50 170.1 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.6 EFA77879.1 - 3.1e-05 23.8 0.0 5.9e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA77879.1 - 0.00019 22.0 0.0 0.0014 19.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFA77879.1 - 0.0004 20.4 0.5 0.0012 18.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA77879.1 - 0.0011 19.6 0.0 0.23 12.1 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77879.1 - 0.0019 18.9 0.0 0.025 15.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFA77879.1 - 0.016 14.7 0.0 0.027 14.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain TFIIF_alpha PF05793.12 EFA77879.1 - 2.4 6.6 7.3 3.4 6.1 7.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf-C4H2 PF10146.9 EFA77881.1 - 0.00022 21.6 2.9 0.00028 21.3 2.9 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein TMCO5 PF14992.6 EFA77881.1 - 0.017 14.7 2.7 0.019 14.6 2.7 1.2 1 0 0 1 1 1 0 TMCO5 family Hexokinase_2 PF03727.16 EFA77882.1 - 0.05 13.0 0.0 0.064 12.7 0.0 1.1 1 0 0 1 1 1 0 Hexokinase DUF5425 PF17472.2 EFA77883.1 - 0.24 12.2 0.1 0.24 12.2 0.1 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5425) Trypan_PARP PF05887.11 EFA77884.1 - 0.0012 18.8 1.3 0.0016 18.4 1.3 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Peptidase_S10 PF00450.22 EFA77885.1 - 1e-114 384.2 1.2 1e-114 384.2 1.2 1.7 1 1 1 2 2 2 1 Serine carboxypeptidase CLU PF13236.6 EFA77885.1 - 2.5e-20 73.3 0.0 1.6e-15 57.5 0.0 2.4 1 1 1 2 2 2 2 Clustered mitochondria AAA_11 PF13086.6 EFA77885.1 - 0.067 13.0 0.4 0.11 12.3 0.4 1.2 1 0 0 1 1 1 0 AAA domain C166 PF17615.2 EFA77885.1 - 0.077 13.1 0.1 0.89 9.7 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function NOA36 PF06524.12 EFA77885.1 - 0.23 10.7 3.6 0.34 10.2 3.6 1.2 1 0 0 1 1 1 0 NOA36 protein Uma2 PF05685.12 EFA77886.1 - 3.4e-10 39.7 0.0 6.4e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 Putative restriction endonuclease OEP PF02321.18 EFA77886.1 - 0.016 15.1 5.0 0.028 14.2 5.0 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein Peptidase_M8 PF01457.16 EFA77888.1 - 1.7e-48 165.7 0.2 2.9e-48 164.9 0.2 1.3 1 0 0 1 1 1 1 Leishmanolysin CLU PF13236.6 EFA77888.1 - 1.6e-05 24.8 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria Kelch_6 PF13964.6 EFA77889.1 - 5.9e-07 29.5 0.4 0.036 14.4 0.1 2.9 2 0 0 2 2 2 2 Kelch motif zf-B_box PF00643.24 EFA77889.1 - 7.6e-07 29.2 7.6 2e-06 27.8 7.6 1.7 1 0 0 1 1 1 1 B-box zinc finger Cep57_CLD PF14073.6 EFA77889.1 - 0.38 10.8 11.3 0.068 13.2 7.2 1.8 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 Ank_2 PF12796.7 EFA77891.1 - 1.2e-27 96.3 3.0 1.9e-06 28.3 0.6 7.2 3 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77891.1 - 3.4e-27 94.5 9.4 0.00027 21.4 0.0 10.2 4 3 5 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA77891.1 - 7.1e-17 61.3 4.4 0.5 10.7 0.0 11.0 7 3 6 13 13 13 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77891.1 - 2.9e-16 57.9 3.2 1.5 9.6 0.0 11.9 13 0 0 13 13 13 2 Ankyrin repeat SMK-1 PF04802.15 EFA77891.1 - 6e-05 23.0 2.0 0.25 11.2 0.3 3.2 3 1 0 3 3 3 2 Component of IIS longevity pathway SMK-1 Ank PF00023.30 EFA77891.1 - 0.0041 17.5 1.0 1.1e+02 3.5 0.0 5.8 6 1 1 7 7 7 0 Ankyrin repeat LURAP PF14854.6 EFA77891.1 - 0.024 14.6 1.7 8 6.5 0.2 4.5 3 1 2 5 5 5 0 Leucine rich adaptor protein DUF3447 PF11929.8 EFA77891.1 - 0.63 10.0 29.2 2.8 8.0 3.1 7.7 3 2 7 10 10 10 0 Domain of unknown function (DUF3447) Peptidase_M8 PF01457.16 EFA77893.1 - 3.9e-46 157.8 0.7 6.6e-46 157.1 0.7 1.3 1 0 0 1 1 1 1 Leishmanolysin 2OG-FeII_Oxy PF03171.20 EFA77894.1 - 1.2e-21 77.1 0.0 1.8e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFA77894.1 - 0.025 15.3 0.0 0.049 14.4 0.0 1.5 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal Apolipoprotein PF01442.18 EFA77896.1 - 0.00042 20.2 11.3 0.00078 19.4 11.3 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain CorA PF01544.18 EFA77896.1 - 0.033 13.5 8.9 0.051 12.9 8.9 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DASH_Dad3 PF08656.10 EFA77896.1 - 0.23 11.6 3.1 0.13 12.4 0.7 1.9 2 0 0 2 2 2 0 DASH complex subunit Dad3 HypA PF01155.19 EFA77896.1 - 1 9.4 4.7 0.59 10.2 0.1 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Baculo_PEP_C PF04513.12 EFA77896.1 - 1.1 9.3 8.0 1.8 8.6 0.9 2.8 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.13 EFA77896.1 - 3.2 8.4 5.1 3.2 8.4 2.8 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) PTS_2-RNA PF01885.16 EFA77897.1 - 6.8e-65 218.5 0.5 7.8e-65 218.3 0.5 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Kelch_6 PF13964.6 EFA77898.1 - 1.1e-08 35.1 6.5 0.00065 19.9 0.4 4.4 4 0 0 4 4 4 3 Kelch motif zf-B_box PF00643.24 EFA77898.1 - 8.6e-07 29.0 6.3 8.6e-07 29.0 6.3 1.7 2 0 0 2 2 2 1 B-box zinc finger Kelch_3 PF13415.6 EFA77898.1 - 0.0014 18.9 0.1 0.14 12.5 0.0 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA77898.1 - 5.9 7.0 5.4 9.8 6.3 0.1 3.6 4 0 0 4 4 4 0 Galactose oxidase, central domain FNIP PF05725.12 EFA77899.1 - 9.3e-17 60.9 27.4 3e-11 43.3 0.7 7.0 4 2 3 7 7 7 6 FNIP Repeat F-box_5 PF18511.1 EFA77899.1 - 0.015 14.9 1.2 0.023 14.2 0.2 1.8 2 0 0 2 2 2 0 F-box Ank_4 PF13637.6 EFA77900.1 - 7.9e-34 115.6 5.2 7.9e-05 23.1 0.0 11.8 8 4 4 13 13 13 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA77900.1 - 2.1e-31 108.3 10.7 4e-06 27.3 0.0 7.9 1 1 8 10 10 10 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA77900.1 - 1.2e-20 73.3 1.1 0.016 15.5 0.0 11.4 4 2 9 13 13 13 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77900.1 - 9.5e-19 65.5 4.6 0.27 11.9 0.0 14.5 18 0 0 18 18 18 2 Ankyrin repeat DUF3447 PF11929.8 EFA77900.1 - 9.2e-07 28.7 24.6 0.18 11.8 0.9 8.0 3 2 2 7 7 7 4 Domain of unknown function (DUF3447) Helicase_PWI PF18149.1 EFA77900.1 - 0.0079 16.4 1.2 0.31 11.2 0.1 3.0 2 0 0 2 2 2 1 N-terminal helicase PWI domain DUF1843 PF08898.10 EFA77900.1 - 0.072 13.6 0.0 52 4.4 0.0 3.9 5 0 0 5 5 5 0 Domain of unknown function (DUF1843) LURAP PF14854.6 EFA77900.1 - 0.52 10.3 7.6 47 4.0 0.0 6.2 4 2 2 7 7 7 0 Leucine rich adaptor protein Telomerase_RBD PF12009.8 EFA77900.1 - 1.4 9.0 6.4 19 5.3 0.4 3.7 3 1 0 3 3 3 0 Telomerase ribonucleoprotein complex - RNA binding domain FNIP PF05725.12 EFA77901.1 - 2.6e-18 65.9 28.2 3.5e-11 43.1 0.3 7.5 4 3 3 7 7 7 6 FNIP Repeat rve PF00665.26 EFA77902.1 - 1.9e-12 47.4 0.0 4.1e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_2 PF12756.7 EFA77903.1 - 0.048 14.0 3.6 0.079 13.3 3.1 1.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Ank_2 PF12796.7 EFA77904.1 - 1.7e-37 127.9 16.0 1.4e-07 32.0 0.0 8.1 1 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA77904.1 - 8.9e-37 125.0 8.3 0.00086 19.8 0.1 11.9 7 3 4 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77904.1 - 4.6e-25 84.9 7.4 1 10.1 0.0 16.6 16 2 2 18 18 18 4 Ankyrin repeat Ank_5 PF13857.6 EFA77904.1 - 3.5e-22 78.2 13.3 0.12 12.7 0.5 14.4 5 4 10 16 16 16 7 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA77904.1 - 3.5e-07 30.1 29.8 0.016 15.1 1.8 8.1 4 3 6 10 10 10 4 Domain of unknown function (DUF3447) DUF5049 PF16468.5 EFA77904.1 - 0.00019 21.3 0.0 1.3 9.0 0.0 5.9 7 1 1 8 8 8 1 Domain of unknown function (DUF5049) DUF249 PF03158.13 EFA77904.1 - 0.0012 18.6 15.0 0.011 15.5 0.4 6.6 3 3 2 7 7 7 1 Multigene family 530 protein DUF4371 PF14291.6 EFA77904.1 - 0.0089 15.7 1.6 3.6 7.2 0.0 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4371) Acetyltransf_17 PF17668.1 EFA77904.1 - 0.027 15.3 0.0 0.22 12.3 0.0 2.5 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain Cloacin_immun PF03513.14 EFA77904.1 - 0.06 13.7 1.1 50 4.3 0.1 4.0 4 0 0 4 4 3 0 Cloacin immunity protein Ank PF00023.30 EFA77904.1 - 0.081 13.4 11.0 3.5e+02 1.9 0.0 9.0 8 2 1 9 9 9 0 Ankyrin repeat FNIP PF05725.12 EFA77905.1 - 2.7e-30 104.2 12.4 3.3e-13 49.6 0.8 7.4 6 3 1 7 7 7 4 FNIP Repeat F-box_5 PF18511.1 EFA77905.1 - 0.0065 16.0 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77905.1 - 0.033 14.1 1.3 0.067 13.1 0.2 2.1 2 0 0 2 2 2 0 F-box-like Erf4 PF10256.9 EFA77906.1 - 0.035 14.2 0.6 0.086 13.0 0.6 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DUF3938 PF13074.6 EFA77906.1 - 0.24 11.7 6.5 0.098 12.9 2.5 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3938) 2TM PF13239.6 EFA77906.1 - 0.72 10.2 3.9 0.46 10.8 0.6 2.0 2 0 0 2 2 2 0 2TM domain Erf4 PF10256.9 EFA77907.1 - 0.013 15.6 0.1 0.024 14.7 0.1 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family AAA_11 PF13086.6 EFA77908.1 - 3.9e-63 213.7 0.0 3.9e-63 213.7 0.0 4.4 2 1 1 3 3 2 1 AAA domain AAA_12 PF13087.6 EFA77908.1 - 4.3e-58 196.2 1.1 4.3e-58 196.2 1.1 2.6 2 1 0 2 2 1 1 AAA domain R3H PF01424.22 EFA77908.1 - 8.4e-14 51.3 0.0 2.2e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 R3H domain AAA_30 PF13604.6 EFA77908.1 - 9e-11 41.8 0.4 1.6e-09 37.7 0.0 2.8 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.6 EFA77908.1 - 5.3e-08 33.3 0.0 4e-07 30.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain zf-AN1 PF01428.16 EFA77908.1 - 2.6e-07 30.7 8.4 4.3e-07 30.0 8.4 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger AAA_16 PF13191.6 EFA77908.1 - 8.3e-05 23.0 0.0 0.00033 21.1 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFA77908.1 - 0.0011 19.2 0.6 0.015 15.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EFA77908.1 - 0.0013 18.6 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_25 PF13481.6 EFA77908.1 - 0.003 17.2 0.1 0.013 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFA77908.1 - 0.0064 16.9 0.6 0.052 14.0 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EFA77908.1 - 0.0081 15.5 0.8 0.0081 15.5 0.8 2.9 2 1 0 2 2 2 1 KaiC Helicase_RecD PF05127.14 EFA77908.1 - 0.019 14.8 2.5 1.4 8.7 0.0 3.7 2 1 0 2 2 2 0 Helicase Viral_helicase1 PF01443.18 EFA77908.1 - 0.057 13.2 16.6 0.2 11.3 0.1 4.4 4 1 0 4 4 4 0 Viral (Superfamily 1) RNA helicase Glyco_tranf_2_3 PF13641.6 EFA77908.1 - 0.08 12.8 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase like family 2 ABC_tran PF00005.27 EFA77908.1 - 0.16 12.5 0.0 0.16 12.5 0.0 3.8 3 1 0 3 3 2 0 ABC transporter Vps39_1 PF10366.9 EFA77908.1 - 2.3 8.5 5.6 2.2 8.6 0.7 3.5 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 1 Transp_Tc5_C PF04236.15 EFA77908.1 - 4 7.9 6.9 8.1 6.9 6.9 1.5 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain ubiquitin PF00240.23 EFA77909.1 - 4.9e-61 202.4 4.7 2.3e-33 113.7 0.6 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFA77909.1 - 7.2e-28 96.2 6.5 1.7e-15 56.6 0.6 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA77909.1 - 6.4e-12 45.8 1.9 0.0002 21.8 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA77909.1 - 3.3e-07 30.4 0.3 0.032 14.3 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFA77909.1 - 4.9e-07 29.6 0.2 0.019 14.9 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA77909.1 - 1.1e-06 28.9 1.3 0.013 15.9 0.1 2.4 2 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFA77909.1 - 1.7e-05 25.3 0.1 0.099 13.2 0.1 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFA77909.1 - 0.00078 19.4 7.1 10 6.2 0.0 4.0 3 1 1 4 4 4 2 Ubiquitin-like domain DUF3861 PF12977.7 EFA77909.1 - 0.038 14.2 0.1 7 6.9 0.0 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) UDP-g_GGTase PF06427.11 EFA77909.1 - 0.039 14.1 1.3 0.55 10.4 0.1 2.5 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase Raf1_HTH PF18579.1 EFA77909.1 - 0.11 12.2 0.0 10 5.9 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain N1221 PF07923.13 EFA77909.1 - 0.13 11.4 0.3 9.1 5.4 0.1 2.1 2 0 0 2 2 2 0 N1221-like protein Plexin_cytopl PF08337.12 EFA77909.1 - 1.4 7.5 5.2 7.8 5.0 0.3 2.7 3 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain FNIP PF05725.12 EFA77910.1 - 1.1e-28 99.1 18.2 1.9e-10 40.7 0.1 7.8 7 1 0 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA77910.1 - 0.02 14.5 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 F-box DUF2634 PF10934.8 EFA77910.1 - 0.032 14.3 0.9 0.075 13.1 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2634) EF-hand_12 PF17901.1 EFA77913.1 - 4e-42 142.6 1.0 4e-42 142.6 1.0 2.7 4 0 0 4 4 4 1 EF-hand fold domain STATa_Ig PF18214.1 EFA77913.1 - 4.6e-25 88.0 1.7 1.4e-24 86.4 1.7 1.9 1 0 0 1 1 1 1 STATa Immunoglobulin-like domain SH2 PF00017.24 EFA77913.1 - 9.4e-10 38.5 0.4 3e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 SH2 domain Dict-STAT-coil PF09267.10 EFA77913.1 - 0.00063 20.1 3.1 0.00063 20.1 3.1 2.6 3 0 0 3 3 3 1 Dictyostelium STAT, coiled coil KCNQ2_u3 PF16642.5 EFA77913.1 - 0.025 15.6 4.8 0.025 15.6 4.8 2.9 3 0 0 3 3 3 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Ribosomal_L29 PF00831.23 EFA77913.1 - 0.2 11.7 1.3 2.6 8.1 0.2 2.8 2 0 0 2 2 2 0 Ribosomal L29 protein DUF1664 PF07889.12 EFA77913.1 - 2.3 8.3 6.9 0.83 9.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) TPT PF03151.16 EFA77914.1 - 1.9e-13 50.5 20.2 2.4e-13 50.1 20.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family Pox_I5 PF04713.12 EFA77914.1 - 0.21 11.6 8.7 0.084 12.9 1.7 3.0 2 1 0 2 2 2 0 Poxvirus protein I5 Metallophos PF00149.28 EFA77915.1 - 2e-17 64.4 3.3 2e-17 64.4 3.3 2.1 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFA77915.1 - 2.1e-17 63.7 0.8 8.6e-17 61.8 0.3 2.4 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EFA77915.1 - 4.7e-14 52.7 4.7 4.7e-14 52.7 4.7 2.7 2 1 1 3 3 3 1 Purple acid Phosphatase, N-terminal domain FNIP PF05725.12 EFA77916.1 - 3.8e-25 87.8 36.2 5.2e-09 36.1 0.4 9.2 7 3 3 10 10 10 4 FNIP Repeat F-box_5 PF18511.1 EFA77916.1 - 0.0002 20.8 0.2 0.00039 19.9 0.2 1.4 1 0 0 1 1 1 1 F-box PLU-1 PF08429.11 EFA77916.1 - 0.058 12.6 0.3 0.53 9.4 0.1 2.2 2 1 0 2 2 2 0 PLU-1-like protein F-box-like PF12937.7 EFA77916.1 - 0.11 12.4 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 F-box-like DUSP PF06337.12 EFA77916.1 - 0.45 11.2 4.0 0.22 12.1 1.1 2.0 2 0 0 2 2 2 0 DUSP domain LRR_4 PF12799.7 EFA77916.1 - 0.61 10.6 19.6 38 4.9 0.1 6.6 6 1 1 7 7 7 0 Leucine Rich repeats (2 copies) ARPC4 PF05856.12 EFA77917.1 - 5.8e-77 257.0 8.4 6.7e-77 256.8 8.4 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) DUF2109 PF09882.9 EFA77917.1 - 1.2 9.2 5.9 1.6 8.8 4.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2109) SUI1 PF01253.22 EFA77918.1 - 2.2e-24 85.8 0.1 3.8e-24 85.0 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Dicty_REP PF05086.12 EFA77918.1 - 0.037 12.0 0.7 0.036 12.1 0.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NST1 PF13945.6 EFA77920.1 - 1.2 9.2 11.9 1.6 8.8 11.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator FNIP PF05725.12 EFA77921.1 - 2.3e-31 107.7 27.3 2.4e-09 37.2 0.7 6.8 3 1 6 9 9 9 8 FNIP Repeat F-box_5 PF18511.1 EFA77921.1 - 0.0067 16.0 0.7 0.55 9.8 0.0 2.4 2 0 0 2 2 2 2 F-box BTB_2 PF02214.22 EFA77922.1 - 0.0005 20.4 0.0 0.0014 18.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ubie_methyltran PF01209.18 EFA77923.1 - 3.1e-24 85.6 0.0 5.7e-21 74.9 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFA77923.1 - 1e-19 71.0 0.0 4.5e-19 68.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA77923.1 - 4.8e-19 68.8 0.0 1.5e-18 67.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA77923.1 - 1.8e-15 57.0 0.0 3.4e-15 56.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77923.1 - 3.6e-13 50.1 0.0 2.4e-12 47.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA77923.1 - 9.2e-11 41.9 0.0 1.6e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EFA77923.1 - 8.3e-06 25.4 0.0 1.8e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.17 EFA77923.1 - 8e-05 22.2 0.0 0.00057 19.4 0.0 2.4 1 1 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EFA77923.1 - 0.00012 21.6 0.1 0.0015 18.1 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFA77923.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EFA77923.1 - 0.0025 17.2 0.3 0.024 14.1 0.3 2.3 1 1 0 1 1 1 1 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 EFA77923.1 - 0.032 13.9 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 EFA77923.1 - 0.074 13.0 0.0 0.22 11.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EFA77923.1 - 0.089 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Response_reg PF00072.24 EFA77923.1 - 0.13 12.4 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Response regulator receiver domain DUF43 PF01861.16 EFA77923.1 - 0.16 11.2 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain FNIP PF05725.12 EFA77924.1 - 1.8e-16 60.0 31.2 2.1e-06 27.8 0.0 8.5 5 3 2 7 7 7 4 FNIP Repeat F-box_5 PF18511.1 EFA77924.1 - 3.2e-08 33.0 0.6 6.6e-08 32.0 0.6 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77924.1 - 0.00037 20.3 0.3 0.001 18.9 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA77924.1 - 0.0035 17.2 0.3 0.015 15.2 0.3 2.1 1 0 0 1 1 1 1 F-box domain Myosin_TH1 PF06017.13 EFA77925.1 - 2.3e-35 122.0 8.4 2.8e-33 115.2 4.2 2.5 2 1 0 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 EFA77925.1 - 0.02 14.6 0.0 0.056 13.2 0.0 1.8 1 0 0 1 1 1 0 Inositol phosphatase Lipase_3 PF01764.25 EFA77926.1 - 4.1e-08 33.2 0.0 9.4e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EFA77926.1 - 0.017 15.7 0.0 0.024 15.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family TFIIA PF03153.13 EFA77926.1 - 0.18 11.8 21.2 0.25 11.3 21.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TP53IP5 PF15331.6 EFA77926.1 - 0.18 11.9 4.6 0.29 11.3 4.6 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF2967 PF11179.8 EFA77926.1 - 0.32 9.0 9.7 0.44 8.6 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Suf PF05843.14 EFA77926.1 - 0.56 10.1 14.0 0.55 10.2 12.5 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Med3 PF11593.8 EFA77926.1 - 2.4 7.3 36.4 3.7 6.6 36.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pex14_N PF04695.13 EFA77926.1 - 2.5 8.7 12.0 5.4 7.6 12.0 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SurA_N_2 PF13623.6 EFA77926.1 - 7 6.5 21.3 0.48 10.3 15.7 1.9 2 0 0 2 2 2 0 SurA N-terminal domain T6SS_HCP PF05638.12 EFA77927.1 - 0.0066 16.8 0.1 0.027 14.9 0.1 2.0 1 1 0 1 1 1 1 Type VI secretion system effector, Hcp Mito_carr PF00153.27 EFA77930.1 - 1.7e-65 216.9 1.5 4.3e-22 77.8 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein Pur_ac_phosph_N PF16656.5 EFA77930.1 - 0.059 13.9 2.0 0.084 13.4 0.7 1.9 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Secretin_N_2 PF07655.13 EFA77930.1 - 4.4 7.9 14.0 2.1 8.9 10.6 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain CDC24_OB1 PF17246.2 EFA77930.1 - 6 7.0 7.4 1.2 9.3 0.1 2.3 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 1 DUF1349 PF07081.11 EFA77931.1 - 1.7e-51 174.5 0.9 9.4e-40 136.2 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1349) GH43_C2 PF17851.1 EFA77931.1 - 1.9e-06 27.8 0.2 3.7e-05 23.6 0.2 2.2 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain BNR PF02012.20 EFA77931.1 - 0.034 14.1 1.1 0.11 12.6 1.1 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat Inj_translocase PF16928.5 EFA77931.1 - 0.053 13.0 0.9 0.065 12.7 0.9 1.2 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome CHB_HEX_C PF03174.13 EFA77931.1 - 0.062 13.3 0.1 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain zf-CCCH PF00642.24 EFA77932.1 - 1.1e-11 44.3 13.0 6.3e-07 29.2 1.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA77932.1 - 3.7e-05 23.6 11.7 0.00036 20.5 1.0 2.4 2 0 0 2 2 2 2 Zinc finger domain RRM_1 PF00076.22 EFA77932.1 - 0.00012 21.8 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EFA77932.1 - 0.0023 18.6 4.4 0.85 10.3 0.1 3.2 3 0 0 3 3 3 2 Torus domain zf-CCCH_3 PF15663.5 EFA77932.1 - 0.089 13.0 0.4 14 6.0 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger containing family Coiled PF05710.12 EFA77933.1 - 1.7e-06 28.7 8.1 2.5e-06 28.2 8.1 1.2 1 0 0 1 1 1 1 Coiled coil Herpes_TK PF00693.18 EFA77933.1 - 0.032 13.5 0.0 0.036 13.3 0.0 1.1 1 0 0 1 1 1 0 Thymidine kinase from herpesvirus Coiled PF05710.12 EFA77934.1 - 1e-07 32.7 5.4 1e-07 32.6 5.4 1.2 1 0 0 1 1 1 1 Coiled coil GCFC PF07842.12 EFA77935.1 - 2.4e-18 66.7 1.7 2e-17 63.7 1.7 2.3 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein UBA_4 PF14555.6 EFA77936.1 - 9.7e-05 22.1 1.7 0.00022 21.0 0.0 2.4 2 0 0 2 2 2 1 UBA-like domain LysM PF01476.20 EFA77936.1 - 0.00034 20.6 0.0 0.00081 19.4 0.0 1.7 1 0 0 1 1 1 1 LysM domain Ndc1_Nup PF09531.10 EFA77936.1 - 0.04 12.6 4.9 0.085 11.5 4.9 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TIG PF01833.24 EFA77937.1 - 6.1e-45 151.2 193.9 3.4e-07 30.2 7.0 18.0 16 3 3 19 19 19 14 IPT/TIG domain Nucleoporin2 PF04096.14 EFA77937.1 - 0.041 14.0 0.0 2.3 8.3 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin autopeptidase EGF_Tenascin PF18720.1 EFA77937.1 - 0.089 12.9 6.4 0.34 11.0 6.4 2.1 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 EFA77937.1 - 0.12 12.7 12.6 0.47 10.9 12.6 2.0 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA77937.1 - 0.23 12.2 8.8 0.87 10.3 8.8 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 EFA77937.1 - 0.29 11.5 8.0 0.83 10.0 8.0 1.8 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 EFA77937.1 - 4.2 7.6 7.4 10 6.4 7.4 1.6 1 0 0 1 1 1 0 Laminin EGF domain Peptidase_M8 PF01457.16 EFA77938.1 - 1.4e-56 192.3 0.7 2.3e-56 191.6 0.7 1.2 1 0 0 1 1 1 1 Leishmanolysin UDG PF03167.19 EFA77938.1 - 0.082 12.9 0.0 0.56 10.2 0.0 2.3 3 0 0 3 3 3 0 Uracil DNA glycosylase superfamily RIX1 PF08167.12 EFA77939.1 - 1.8e-09 37.6 6.7 1.8e-09 37.6 6.7 2.8 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis BSP_II PF05432.11 EFA77939.1 - 0.0046 16.7 28.7 0.0046 16.7 28.7 1.9 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) HEAT PF02985.22 EFA77939.1 - 0.044 14.0 0.0 1.9 8.9 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat Peptidase_C1 PF00112.23 EFA77940.1 - 1e-81 274.2 10.0 1.5e-81 273.7 10.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA77940.1 - 3.8e-14 52.8 5.1 7.9e-14 51.8 5.1 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA77940.1 - 0.00031 19.7 2.5 0.015 14.1 0.8 2.3 2 0 0 2 2 2 2 Peptidase C1-like family S1 PF00575.23 EFA77940.1 - 0.07 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 S1 RNA binding domain FNIP PF05725.12 EFA77941.1 - 5.3e-18 64.9 5.2 2.3e-10 40.5 0.6 3.1 2 1 0 3 3 3 2 FNIP Repeat F-box_5 PF18511.1 EFA77941.1 - 0.008 15.7 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA77941.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 F-box-like zf-B_box PF00643.24 EFA77942.1 - 0.00064 19.8 12.3 0.00064 19.8 12.3 2.4 2 0 0 2 2 2 1 B-box zinc finger C1_2 PF03107.16 EFA77942.1 - 0.49 10.8 14.3 0.2 12.0 6.8 2.7 2 0 0 2 2 2 0 C1 domain FNIP PF05725.12 EFA77943.1 - 8.7e-26 89.8 32.7 5.3e-09 36.1 0.2 9.2 6 3 3 9 9 9 6 FNIP Repeat F-box_5 PF18511.1 EFA77943.1 - 0.0011 18.5 0.1 0.0025 17.4 0.1 1.6 1 0 0 1 1 1 1 F-box Neur_chan_memb PF02932.16 EFA77944.1 - 0.1 12.6 13.4 0.038 14.0 0.7 2.8 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3464 PF11947.8 EFA77944.1 - 2 8.2 5.9 1.2 8.9 0.3 2.6 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 CRA PF06589.11 EFA77944.1 - 2.2 8.4 7.7 1.2 9.3 0.1 3.4 3 0 0 3 3 3 0 Circumsporozoite-related antigen (CRA) SR-25 PF10500.9 EFA77944.1 - 3.8 7.1 27.5 0.054 13.1 1.1 2.8 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein DUF2149 PF09919.9 EFA77944.1 - 4.7 7.5 7.3 36 4.7 0.0 4.1 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2149) FNIP_N PF14636.6 EFA77944.1 - 8.7 7.3 16.8 1.1 10.3 5.5 2.8 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus Glycoprot_B_PH2 PF17417.2 EFA77945.1 - 0.079 13.3 0.1 0.16 12.3 0.1 1.5 1 1 0 1 1 1 0 Herpesvirus Glycoprotein B PH-like domain SPOUT_MTase PF02590.17 EFA77946.1 - 0.055 13.5 2.3 0.14 12.1 0.0 2.5 3 0 0 3 3 3 0 Predicted SPOUT methyltransferase OST3_OST6 PF04756.13 EFA77947.1 - 4.7e-50 170.6 2.5 1.1e-49 169.4 2.5 1.6 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family CD34_antigen PF06365.12 EFA77947.1 - 0.015 14.9 0.0 2.6 7.6 0.0 2.5 2 0 0 2 2 2 0 CD34/Podocalyxin family EGF_2 PF07974.13 EFA77947.1 - 0.016 15.5 11.8 0.04 14.3 11.8 1.7 1 0 0 1 1 1 0 EGF-like domain ETRAMP PF09716.10 EFA77947.1 - 0.073 13.1 0.3 0.32 11.1 0.1 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) EB PF01683.18 EFA77947.1 - 0.13 12.6 3.2 0.35 11.2 3.2 1.7 1 0 0 1 1 1 0 EB module DUF4293 PF14126.6 EFA77947.1 - 0.16 12.2 1.8 7 6.9 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) EGF_Tenascin PF18720.1 EFA77947.1 - 0.19 11.8 7.1 0.4 10.8 7.1 1.5 1 0 0 1 1 1 0 Tenascin EGF domain SKG6 PF08693.10 EFA77947.1 - 0.19 11.2 2.9 0.69 9.4 2.9 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Romo1 PF10247.9 EFA77947.1 - 0.25 11.7 1.7 0.4 11.1 0.2 2.2 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 EphA2_TM PF14575.6 EFA77947.1 - 0.29 12.0 1.1 5.4 8.0 0.3 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF5518 PF17647.1 EFA77947.1 - 2.1 8.5 12.0 0.33 11.1 0.8 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5518) Ank_2 PF12796.7 EFA77948.1 - 1.8e-28 98.9 8.6 2.2e-06 28.2 0.1 5.8 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA77948.1 - 7.6e-28 96.2 10.4 0.0081 16.5 0.0 11.0 4 3 8 12 12 12 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA77948.1 - 1.6e-23 82.8 8.0 0.0002 21.8 0.1 8.2 6 2 2 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA77948.1 - 4.9e-14 51.1 5.4 2.6 8.9 0.0 10.2 11 1 0 11 11 11 3 Ankyrin repeat Ank PF00023.30 EFA77948.1 - 9e-05 22.8 0.6 40 4.9 0.0 7.2 2 2 1 4 4 4 0 Ankyrin repeat Thioredoxin_6 PF13848.6 EFA77949.1 - 0.03 14.2 0.0 0.041 13.8 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain MFS_1 PF07690.16 EFA77950.1 - 2.3e-41 141.9 16.7 2.5e-40 138.5 6.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA77950.1 - 2e-08 33.5 10.2 2e-08 33.5 10.2 2.1 1 1 1 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EFA77950.1 - 4.7e-08 31.8 6.0 4.7e-08 31.8 6.0 2.5 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EFA77950.1 - 0.082 11.3 14.2 0.44 8.9 5.3 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector Mago_nashi PF02792.14 EFA77950.1 - 0.42 10.7 3.2 14 5.8 0.4 2.3 2 0 0 2 2 2 0 Mago nashi protein DUF4231 PF14015.6 EFA77950.1 - 1.3 9.6 8.0 3 8.4 1.5 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) Ank_4 PF13637.6 EFA77951.1 - 0.0014 19.1 0.2 0.79 10.4 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA77951.1 - 0.0099 16.4 0.1 0.066 13.8 0.0 2.4 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) PilJ_C PF18223.1 EFA77952.1 - 0.12 12.9 0.5 0.28 11.7 0.5 1.6 1 0 0 1 1 1 0 Pili PilJ C-terminal domain Methyltransf_11 PF08241.12 EFA77953.1 - 7.5e-21 74.6 0.0 1.5e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA77953.1 - 3.3e-18 66.2 0.0 8.6e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA77953.1 - 3.2e-15 56.1 0.0 8e-15 54.8 0.0 1.7 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFA77953.1 - 1.8e-13 50.6 0.0 4.3e-13 49.3 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA77953.1 - 7.6e-13 48.6 0.0 1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA77953.1 - 1.7e-10 41.5 0.0 3.8e-10 40.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.11 EFA77953.1 - 0.00067 19.3 0.0 0.00095 18.8 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.12 EFA77953.1 - 0.0034 17.0 0.0 0.011 15.4 0.0 1.8 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 EFA77953.1 - 0.01 15.7 0.0 0.017 14.9 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_29 PF03141.16 EFA77953.1 - 0.013 14.1 0.0 0.023 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 EFA77953.1 - 0.02 14.6 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Dermcidin PF15291.6 EFA77954.1 - 0.083 13.4 1.3 0.11 13.1 1.3 1.3 1 0 0 1 1 1 0 Dermcidin, antibiotic peptide Acyl-CoA_dh_M PF02770.19 EFA77956.1 - 4.2e-18 65.3 0.0 7.3e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFA77956.1 - 9.6e-09 35.6 0.0 1.9e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ACOX PF01756.19 EFA77956.1 - 7e-08 32.2 0.0 1.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EFA77956.1 - 0.0041 17.7 0.0 0.0096 16.5 0.0 1.7 1 1 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Stealth_CR2 PF11380.8 EFA77958.1 - 1.5e-13 50.9 2.5 8.7e-13 48.4 2.5 2.4 1 1 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EFA77958.1 - 1.1e-12 47.7 0.7 2.4e-12 46.6 0.7 1.7 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 EFA77958.1 - 8.7e-12 44.6 0.5 8.7e-12 44.6 0.5 1.8 2 0 0 2 2 2 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 EFA77958.1 - 1.2e-07 31.5 0.1 3.1e-07 30.2 0.1 1.8 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 DUF5481 PF17578.2 EFA77958.1 - 0.0061 17.0 0.1 0.02 15.3 0.1 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5481) Got1 PF04178.12 EFA77959.1 - 2.2e-12 47.4 8.4 3.1e-12 46.9 8.4 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF202 PF02656.15 EFA77959.1 - 1.7 9.2 4.3 1.6 9.2 2.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF202) UL41A PF17591.2 EFA77959.1 - 1.7 8.8 4.4 2.6 8.2 4.2 1.5 1 1 0 1 1 1 0 Herpesvirus UL41A zf-DNL PF05180.12 EFA77960.1 - 5.5e-21 74.3 2.1 1.2e-20 73.2 2.1 1.6 1 0 0 1 1 1 1 DNL zinc finger DUF1481 PF07356.12 EFA77960.1 - 0.012 15.3 1.5 0.02 14.7 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1481) DUF5364 PF17322.2 EFA77962.1 - 0.89 9.8 11.8 0.23 11.8 3.2 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5364) Ank_2 PF12796.7 EFA77964.1 - 1.1e-05 26.0 3.9 0.028 15.0 0.1 3.7 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA77964.1 - 0.00017 21.8 1.9 14 6.7 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFA77964.1 - 0.0004 20.9 1.9 9.7 6.9 0.0 5.1 5 1 0 5 5 5 1 Ankyrin repeats (many copies) FKBP26_C PF18046.1 EFA77964.1 - 0.14 12.3 0.3 1.7 8.8 0.0 2.8 3 0 0 3 3 3 0 FKBP26_C-terminal Secretin_N_2 PF07655.13 EFA77964.1 - 1.4 9.5 10.4 2.7 8.6 10.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Mtc PF03820.17 EFA77965.1 - 1.4e-112 375.8 0.0 1.6e-112 375.6 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Mpt_N PF09176.11 EFA77965.1 - 0.02 15.0 0.0 3.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal RNB PF00773.19 EFA77967.1 - 9.6e-58 196.0 2.4 2e-57 195.0 2.4 1.5 1 0 0 1 1 1 1 RNB domain TFIIA PF03153.13 EFA77967.1 - 1.2 9.0 38.2 0.17 11.9 18.3 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Beta_helix PF13229.6 EFA77968.1 - 1.9e-13 50.6 59.6 5.5e-12 45.8 14.2 5.7 2 1 3 5 5 5 4 Right handed beta helix region NosD PF05048.13 EFA77968.1 - 1.8e-05 24.1 14.2 1.8e-05 24.1 14.2 5.6 3 1 2 5 5 5 2 Periplasmic copper-binding protein (NosD) Flp_Fap PF04964.14 EFA77968.1 - 2 8.3 3.9 1.6 8.6 0.6 2.7 3 0 0 3 3 3 0 Flp/Fap pilin component EphA2_TM PF14575.6 EFA77969.1 - 0.072 14.0 0.3 0.16 12.9 0.3 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain O-antigen_lig PF13425.6 EFA77969.1 - 0.24 10.1 2.6 0.25 10.1 2.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Chordopox_A13L PF05961.11 EFA77969.1 - 0.32 11.2 3.1 0.38 11.0 1.8 1.9 2 1 0 2 2 2 0 Chordopoxvirus A13L protein ETRAMP PF09716.10 EFA77969.1 - 0.96 9.6 6.4 4.4 7.4 2.2 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FNIP PF05725.12 EFA77970.1 - 3.4e-08 33.5 19.1 0.14 12.3 0.1 8.0 6 2 2 8 8 8 5 FNIP Repeat DUF3656 PF12392.8 EFA77970.1 - 0.035 14.8 0.2 0.6 10.8 0.0 2.5 2 0 0 2 2 2 0 Collagenase CBS PF00571.28 EFA77972.1 - 4.8e-26 91.0 0.3 8.4e-13 48.6 0.1 2.3 2 0 0 2 2 2 2 CBS domain MinC_C PF03775.16 EFA77973.1 - 2.2e-27 95.0 0.0 3.9e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Septum formation inhibitor MinC, C-terminal domain MinC_N PF05209.13 EFA77973.1 - 3e-11 43.2 0.0 4.9e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Septum formation inhibitor MinC, N-terminal domain FapA PF03961.13 EFA77973.1 - 0.049 12.2 0.1 0.074 11.6 0.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A MSP1_C PF07462.11 EFA77973.1 - 0.2 10.3 2.8 0.26 9.9 2.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus CCDC84 PF14968.6 EFA77973.1 - 0.52 9.9 4.7 0.73 9.4 4.7 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Sporozoite_P67 PF05642.11 EFA77973.1 - 0.81 7.7 9.9 1 7.4 9.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MccV PF17508.2 EFA77973.1 - 0.9 10.1 7.0 1 10.0 5.2 1.9 1 1 0 1 1 1 0 Microcin V bacteriocin RAI1 PF08652.11 EFA77974.1 - 3.8e-20 71.8 0.4 1.1e-19 70.3 0.4 1.9 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease COBRA1 PF06209.13 EFA77974.1 - 2.8e-05 23.2 0.9 2.8e-05 23.2 0.9 1.7 2 0 0 2 2 2 1 Cofactor of BRCA1 (COBRA1) Actin PF00022.19 EFA77975.1 - 3.4e-49 167.6 0.0 5e-28 97.8 0.0 2.8 2 1 0 2 2 2 2 Actin MDH PF02315.16 EFA77975.1 - 3.4 7.8 6.0 0.7 10.0 0.0 2.7 3 1 0 3 3 3 0 Methanol dehydrogenase beta subunit PTPS PF01242.19 EFA77977.1 - 1.6e-33 115.3 0.8 1.8e-33 115.1 0.8 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase SNF2_N PF00176.23 EFA77978.1 - 8.8e-61 205.6 1.2 1.7e-60 204.6 1.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1295 PF06966.12 EFA77978.1 - 2.8e-41 141.6 7.8 4.3e-41 141.0 7.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Chromo PF00385.24 EFA77978.1 - 1.3e-22 79.5 1.6 8.4e-11 41.6 0.4 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EFA77978.1 - 4.3e-19 68.9 0.1 2.9e-18 66.2 0.0 2.6 3 0 0 3 3 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA77978.1 - 3.2e-10 40.3 0.0 3.2e-10 40.3 0.0 3.5 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Ank_2 PF12796.7 EFA77978.1 - 2.5e-07 31.2 0.1 0.0001 22.8 0.0 2.8 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) CHDCT2 PF08074.11 EFA77978.1 - 2.1e-05 24.8 1.1 0.0017 18.6 0.0 3.5 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain Ank_5 PF13857.6 EFA77978.1 - 0.0024 18.1 0.0 6.1 7.3 0.0 3.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA77978.1 - 0.0028 18.2 0.2 2.5 8.8 0.0 4.0 3 1 2 5 5 5 2 Ankyrin repeats (many copies) DEAD PF00270.29 EFA77978.1 - 0.0042 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1086 PF06461.11 EFA77978.1 - 0.0075 16.1 0.2 0.34 10.8 0.0 2.9 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1086) Ank_3 PF13606.6 EFA77978.1 - 0.065 13.8 0.0 1.5 9.7 0.0 3.3 2 0 0 2 2 2 0 Ankyrin repeat ICMT PF04140.14 EFA77978.1 - 0.081 13.4 0.2 0.23 11.9 0.2 1.7 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AT_hook PF02178.19 EFA77978.1 - 0.61 10.1 4.1 2.6 8.2 0.9 3.0 2 0 0 2 2 2 0 AT hook motif LINES_N PF14694.6 EFA77979.1 - 1.1e-10 41.6 3.2 1.1e-10 41.6 3.2 1.9 2 0 0 2 2 2 1 Lines N-terminus LINES_C PF14695.6 EFA77979.1 - 0.00038 19.8 0.0 0.00082 18.8 0.0 1.6 1 0 0 1 1 1 1 Lines C-terminus TFIIA PF03153.13 EFA77979.1 - 0.4 10.6 9.8 0.074 13.0 1.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ecl1 PF12855.7 EFA77979.1 - 5 8.3 51.3 4.8 8.3 21.8 3.5 3 0 0 3 3 3 0 ECL1/2/3 zinc binding proteins FUSC_2 PF13515.6 EFA77980.1 - 4.7e-21 75.2 17.8 4.7e-21 75.2 17.8 3.5 2 1 1 3 3 3 1 Fusaric acid resistance protein-like FUSC PF04632.12 EFA77980.1 - 0.00059 18.5 2.2 0.00059 18.5 2.2 1.8 2 0 0 2 2 2 1 Fusaric acid resistance protein family Coa1 PF08695.10 EFA77980.1 - 0.098 12.4 0.0 0.41 10.4 0.0 2.1 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 ArAE_2 PF10334.9 EFA77980.1 - 0.17 11.7 0.6 0.31 10.8 0.6 1.3 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 PDZ_3 PF17815.1 EFA77980.1 - 1.6 8.6 3.7 0.91 9.4 0.8 2.0 2 0 0 2 2 2 0 PDZ domain Myb_DNA-binding PF00249.31 EFA77981.1 - 2e-51 171.9 35.4 7.8e-16 58.0 0.5 5.6 5 1 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA77981.1 - 1.3e-45 153.5 18.9 8.4e-13 48.4 0.0 5.8 1 1 4 5 5 5 5 Myb-like DNA-binding domain Rap1_C PF11626.8 EFA77981.1 - 0.0015 18.6 5.9 1.6 8.9 0.9 4.3 2 1 2 4 4 4 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 EFA77981.1 - 0.9 9.6 0.0 0.9 9.6 0.0 7.0 6 1 2 8 8 8 0 SLIDE LRR_9 PF14580.6 EFA77982.1 - 5.5e-11 42.3 0.6 5.5e-11 42.3 0.6 2.5 2 1 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 EFA77982.1 - 6.4e-05 22.6 2.2 0.00049 19.8 0.0 2.7 2 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EFA77982.1 - 0.0022 18.4 3.6 0.015 15.7 0.4 3.6 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) DUF4407 PF14362.6 EFA77982.1 - 1.2 8.4 6.5 1.6 8.0 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EFA77982.1 - 6.8 4.5 12.7 27 2.5 11.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RNase_H PF00075.24 EFA77983.1 - 5.2e-14 52.6 0.0 1.5e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 RNase H Peptidase_C97 PF05903.14 EFA77984.1 - 2.3e-25 89.2 0.1 2.7e-25 89.0 0.1 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain RRM_1 PF00076.22 EFA77985.1 - 1.7e-59 197.5 0.8 1.1e-22 79.6 0.2 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA77985.1 - 3.7e-10 39.5 0.3 0.039 13.6 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFA77985.1 - 6.3e-08 32.6 0.1 0.0071 16.4 0.0 2.6 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 EFA77985.1 - 2.2e-05 24.2 0.1 0.65 9.9 0.0 3.3 3 1 0 3 3 3 2 Occluded RNA-recognition motif BRAP2 PF07576.12 EFA77985.1 - 0.00014 22.0 0.0 0.3 11.3 0.0 2.4 2 0 0 2 2 2 2 BRCA1-associated protein 2 RRM_7 PF16367.5 EFA77985.1 - 0.0081 16.3 0.0 12 6.1 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif Macoilin PF09726.9 EFA77985.1 - 1.3 7.5 19.5 1.7 7.1 19.5 1.2 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 EFA77985.1 - 1.9 6.6 11.8 3 5.9 11.8 1.2 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 EFA77985.1 - 5.8 5.6 8.1 9.5 4.9 8.1 1.4 1 0 0 1 1 1 0 Presenilin UQ_con PF00179.26 EFA77986.1 - 1.1e-37 128.8 0.1 2.7e-37 127.5 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EFA77986.1 - 0.022 14.6 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EFA77986.1 - 0.1 12.9 0.2 0.22 11.8 0.2 1.6 1 1 0 1 1 1 0 RWD domain DUF3087 PF11286.8 EFA77989.1 - 0.078 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) CTK3 PF12243.8 EFA77990.1 - 7.1e-05 22.8 0.1 7.1e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 Ribosomal_L7Ae PF01248.26 EFA77991.1 - 1.4e-26 92.0 0.1 1.9e-26 91.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EFA77991.1 - 0.0016 18.5 0.2 0.0019 18.3 0.2 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 EFA77991.1 - 0.028 14.3 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Mannitol_dh_C PF08125.13 EFA77992.1 - 1.8e-64 217.5 0.0 2.3e-64 217.2 0.0 1.1 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EFA77992.1 - 3.9e-29 101.8 0.0 6.4e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain IMS_C PF11799.8 EFA77992.1 - 0.089 13.5 0.0 6.9 7.4 0.0 2.5 2 0 0 2 2 2 0 impB/mucB/samB family C-terminal domain FANCL_C PF11793.8 EFA77992.1 - 0.12 12.5 0.2 0.34 11.1 0.2 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain GARS_A PF01071.19 EFA77993.1 - 1.7e-72 243.3 0.0 3.1e-72 242.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 EFA77993.1 - 1.1e-33 116.5 0.0 2.9e-33 115.2 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 EFA77993.1 - 2.6e-29 101.8 0.9 5.9e-29 100.7 0.2 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 EFA77993.1 - 1.8e-25 89.0 0.3 5.8e-25 87.4 0.1 2.1 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EFA77993.1 - 1.7e-13 51.0 2.8 4.5e-13 49.7 1.5 2.5 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain CPSase_L_D2 PF02786.17 EFA77993.1 - 5.5e-06 26.0 0.1 1e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 EFA77993.1 - 0.00054 19.6 0.1 0.001 18.7 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EFA77993.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EFA77993.1 - 0.0025 17.9 0.0 0.011 15.8 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EFA77993.1 - 0.0059 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 EFA77993.1 - 0.022 14.3 0.0 0.048 13.3 0.0 1.5 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFA77993.1 - 0.076 12.5 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus EGF_2 PF07974.13 EFA77994.1 - 0.00017 21.8 33.2 0.015 15.7 9.6 2.4 2 0 0 2 2 2 2 EGF-like domain EGF PF00008.27 EFA77994.1 - 2.6 8.4 26.1 4.1 7.8 11.5 2.5 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 EFA77995.1 - 0.064 13.6 6.6 0.11 12.8 6.6 1.4 1 0 0 1 1 1 0 EGF-like domain PRKCSH_1 PF13015.6 EFA77996.1 - 3.5e-07 30.0 0.1 8.5e-07 28.8 0.1 1.5 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA77996.1 - 1.7e-06 28.2 10.7 9.9e-05 22.4 6.1 2.4 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat SWI-SNF_Ssr4 PF08549.10 EFA77996.1 - 2.4 6.7 11.0 3.1 6.3 11.0 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PRKCSH_1 PF13015.6 EFA77997.1 - 9.9e-06 25.3 1.5 4.3e-05 23.2 0.3 2.4 1 1 1 2 2 2 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA77997.1 - 8.3e-05 22.7 13.2 0.00012 22.2 3.6 2.7 3 0 0 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat DUF5105 PF17118.5 EFA77997.1 - 2.4 7.9 8.2 0.55 10.0 5.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5105) AAA PF00004.29 EFA77998.1 - 5.2e-16 59.3 0.1 2e-15 57.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFA77998.1 - 1.4e-10 41.5 0.0 2.9e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFA77998.1 - 3.8e-08 33.9 0.1 8.4e-07 29.5 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 EFA77998.1 - 6.6e-08 32.6 0.1 2.5e-07 30.7 0.1 2.0 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 EFA77998.1 - 0.00025 21.4 0.1 0.0018 18.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFA77998.1 - 0.01 15.4 0.0 0.06 12.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 EFA77998.1 - 0.029 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EFA77998.1 - 0.032 14.0 0.0 0.068 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFA77998.1 - 0.033 13.4 0.0 0.086 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 EFA77998.1 - 0.033 14.0 0.0 0.033 14.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain ResIII PF04851.15 EFA77998.1 - 0.05 13.6 0.0 0.05 13.6 0.0 4.2 3 1 1 4 4 3 0 Type III restriction enzyme, res subunit PIF1 PF05970.14 EFA77998.1 - 0.14 11.3 0.0 0.14 11.3 0.0 1.9 2 0 0 2 2 2 0 PIF1-like helicase AAA_18 PF13238.6 EFA77998.1 - 0.16 12.5 0.0 0.16 12.5 0.0 3.6 4 1 0 4 4 3 0 AAA domain Sod_Cu PF00080.20 EFA78000.1 - 5.8e-31 107.6 12.6 1.4e-26 93.3 0.7 3.7 3 0 0 3 3 3 2 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.20 EFA78001.1 - 4.3e-33 114.5 8.1 5.7e-27 94.6 1.5 2.4 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) Cu-oxidase_2 PF07731.14 EFA78001.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Multicopper oxidase Glyco_transf_7C PF02709.14 EFA78002.1 - 9.4e-06 25.2 7.6 4.7 7.0 0.0 6.6 7 0 0 7 7 7 2 N-terminal domain of galactosyltransferase DNA_methylase PF00145.17 EFA78002.1 - 0.00081 18.8 5.6 0.15 11.3 5.4 2.8 3 0 0 3 3 3 2 C-5 cytosine-specific DNA methylase PAT1 PF09770.9 EFA78002.1 - 1.8 6.8 30.8 2.3 6.4 30.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 EFA78002.1 - 3.7 7.5 51.1 5.9 6.8 51.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Endotoxin_N PF03945.14 EFA78003.1 - 1.3e-20 74.1 2.2 1.8e-20 73.6 0.9 1.8 2 0 0 2 2 2 1 delta endotoxin, N-terminal domain ADH_zinc_N_2 PF13602.6 EFA78004.1 - 3.6e-18 66.9 0.0 6.9e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFA78004.1 - 1.3e-11 44.6 0.0 3.3e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA78004.1 - 4.5e-10 39.4 0.8 4.5e-10 39.4 0.8 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF3730 PF12530.8 EFA78004.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) DUF2024 PF09630.10 EFA78006.1 - 0.09 12.7 0.0 0.09 12.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) Ribosomal_L4 PF00573.22 EFA78007.1 - 1.5e-37 129.2 0.3 2.3e-37 128.6 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EFA78007.1 - 1.5e-22 79.4 2.1 2e-22 79.0 0.9 1.8 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Sec23_trunk PF04811.15 EFA78008.1 - 3.1e-29 102.3 0.0 6e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EFA78008.1 - 6.7e-24 83.7 0.1 2e-23 82.2 0.1 1.9 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EFA78008.1 - 2.8e-16 60.0 0.0 6.9e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFA78008.1 - 1.8e-12 47.0 3.4 3.9e-12 46.0 2.0 2.2 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFA78008.1 - 7.3e-05 22.6 0.2 0.00038 20.3 0.0 2.4 2 0 0 2 2 2 1 Gelsolin repeat Pyr_redox_2 PF07992.14 EFA78009.1 - 7.6e-35 120.6 0.0 1.7e-34 119.4 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA78009.1 - 1.4e-15 57.6 0.3 1.8e-09 38.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA78009.1 - 5.8e-09 35.6 0.0 2.3e-05 23.8 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFA78009.1 - 4.4e-06 26.8 0.0 1.6 8.7 0.0 3.5 3 1 0 3 3 3 3 FAD-NAD(P)-binding K_oxygenase PF13434.6 EFA78009.1 - 0.00037 19.7 0.0 1.1 8.4 0.0 2.8 3 1 1 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFA78009.1 - 0.0055 16.3 0.1 0.067 12.8 0.0 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EFA78009.1 - 0.008 15.1 0.0 0.039 12.8 0.0 2.0 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 EFA78009.1 - 0.018 15.2 0.0 0.061 13.6 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFA78009.1 - 0.024 13.4 0.1 0.4 9.3 0.0 2.6 3 1 1 4 4 4 0 HI0933-like protein Lycopene_cycl PF05834.12 EFA78009.1 - 0.11 11.5 0.0 3.4 6.6 0.0 3.0 4 0 0 4 4 4 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EFA78009.1 - 0.17 11.1 0.2 0.6 9.3 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain TrkA_N PF02254.18 EFA78009.1 - 0.24 11.7 3.2 6.1 7.1 0.0 3.2 4 1 0 4 4 4 0 TrkA-N domain Myotub-related PF06602.14 EFA78011.1 - 1e-27 97.0 0.1 1.1e-27 96.9 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain COR PF16095.5 EFA78013.1 - 1.6e-52 178.1 0.0 2.7e-52 177.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase_Tyr PF07714.17 EFA78013.1 - 3.9e-51 173.8 0.0 8.5e-51 172.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA78013.1 - 2e-40 138.8 0.0 1.2e-39 136.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Roc PF08477.13 EFA78013.1 - 1e-21 77.3 1.1 2e-21 76.4 1.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 EFA78013.1 - 2.2e-21 75.4 47.7 2.8e-06 27.0 4.0 5.8 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFA78013.1 - 2.7e-19 68.9 52.8 6.4e-05 23.2 9.8 7.4 3 2 1 6 6 6 6 Leucine Rich repeats (2 copies) Ras PF00071.22 EFA78013.1 - 1.5e-10 40.9 1.1 3.5e-10 39.7 1.1 1.5 1 1 0 1 1 1 1 Ras family Arf PF00025.21 EFA78013.1 - 3.7e-05 23.3 2.5 0.00023 20.6 2.5 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA78013.1 - 0.0019 18.3 0.9 0.0067 16.5 0.9 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase LRR_9 PF14580.6 EFA78013.1 - 0.0029 17.2 20.4 0.032 13.7 3.9 3.6 2 1 1 3 3 3 3 Leucine-rich repeat Septin PF00735.18 EFA78013.1 - 0.013 14.8 0.1 0.028 13.7 0.1 1.5 1 0 0 1 1 1 0 Septin SRPRB PF09439.10 EFA78013.1 - 0.025 14.0 0.8 0.067 12.6 0.8 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EFA78013.1 - 0.032 13.7 0.1 0.068 12.6 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein T4_Rnl2_C PF18043.1 EFA78013.1 - 0.049 13.8 0.2 0.14 12.3 0.2 1.8 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal Gtr1_RagA PF04670.12 EFA78013.1 - 0.05 12.9 0.4 0.09 12.1 0.4 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EFA78013.1 - 0.053 13.8 0.1 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EFA78013.1 - 0.11 12.2 0.5 0.31 10.8 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation LRR_6 PF13516.6 EFA78013.1 - 0.12 12.5 41.5 0.21 11.7 0.1 10.2 11 0 0 11 11 9 0 Leucine Rich repeat APH PF01636.23 EFA78013.1 - 0.21 11.5 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_1 PF00560.33 EFA78013.1 - 0.45 11.2 43.9 12 6.9 0.8 10.9 10 1 1 11 11 10 0 Leucine Rich Repeat GMC_oxred_N PF00732.19 EFA78014.1 - 1.4e-35 123.1 0.0 2.1e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA78014.1 - 1.5e-23 83.9 0.0 3.1e-23 82.9 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EFA78014.1 - 0.0022 17.3 0.0 0.019 14.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFA78014.1 - 0.016 14.5 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EFA78014.1 - 0.024 13.7 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein TrkA_N PF02254.18 EFA78014.1 - 0.036 14.3 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain HI0933_like PF03486.14 EFA78014.1 - 0.07 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein GDI PF00996.18 EFA78014.1 - 0.12 10.9 0.0 0.23 10.0 0.0 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EFA78014.1 - 0.16 12.3 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain CGI-121 PF08617.10 EFA78015.1 - 2.6e-27 95.9 1.0 3.1e-27 95.7 1.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Spore_III_AB PF09548.10 EFA78016.1 - 1.3 9.1 5.7 12 6.0 0.0 3.9 4 1 0 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) DAG_kinase_N PF14513.6 EFA78017.1 - 0.027 14.7 2.7 0.034 14.4 2.7 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Ank_2 PF12796.7 EFA78018.1 - 1.8e-36 124.6 15.5 5.4e-06 26.9 0.1 6.8 2 1 7 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78018.1 - 2e-29 101.5 8.2 1.1e-05 25.8 0.0 9.0 8 1 1 9 9 9 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78018.1 - 9.9e-29 99.0 13.3 0.0029 17.9 0.0 11.8 4 1 9 13 13 13 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78018.1 - 2e-17 61.5 9.4 6 7.8 0.0 13.2 13 2 2 15 15 15 3 Ankyrin repeat DUF5049 PF16468.5 EFA78018.1 - 1.4e-08 34.5 0.2 5 7.1 0.0 8.5 4 3 5 9 9 9 1 Domain of unknown function (DUF5049) DUF249 PF03158.13 EFA78018.1 - 6.1e-06 26.1 16.9 0.00095 18.9 1.1 5.9 3 2 2 5 5 5 2 Multigene family 530 protein HA PF03457.14 EFA78018.1 - 0.047 14.0 0.0 6.5 7.2 0.0 3.9 2 1 2 4 4 4 0 Helicase associated domain Ank PF00023.30 EFA78018.1 - 0.29 11.6 1.9 3.7e+02 1.9 0.1 6.2 5 3 0 5 5 5 0 Ankyrin repeat FA_desaturase PF00487.24 EFA78019.1 - 7.3e-24 85.0 39.1 7e-15 55.6 22.4 3.4 2 2 0 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.28 EFA78019.1 - 1.2e-12 47.8 0.1 3e-12 46.5 0.1 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain YibE_F PF07907.11 EFA78019.1 - 0.00075 19.1 1.7 0.024 14.1 1.0 2.6 2 0 0 2 2 2 1 YibE/F-like protein Dehydratase_hem PF13816.6 EFA78019.1 - 0.0082 15.6 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Haem-containing dehydratase BCNT PF07572.12 EFA78020.1 - 9.5e-19 67.3 1.5 9.5e-19 67.3 1.5 2.0 2 0 0 2 2 2 1 Bucentaur or craniofacial development Rrn6 PF10214.9 EFA78020.1 - 0.27 9.7 11.9 0.28 9.6 11.9 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MscS_TM PF12794.7 EFA78020.1 - 3.7 6.3 7.3 5.5 5.7 7.3 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CRAL_TRIO_2 PF13716.6 EFA78021.1 - 1.5e-20 73.8 2.2 3.5e-20 72.6 2.2 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Macro PF01661.21 EFA78021.1 - 2.5e-17 63.0 0.7 1.2e-16 60.8 0.1 2.1 2 0 0 2 2 2 1 Macro domain CRAL_TRIO PF00650.20 EFA78021.1 - 3.4e-05 23.6 2.4 0.00012 21.8 2.4 1.9 1 1 0 1 1 1 1 CRAL/TRIO domain zinc_ribbon_10 PF10058.9 EFA78022.1 - 1.6e-17 63.0 0.8 3.2e-17 62.0 0.8 1.6 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein ubiquitin PF00240.23 EFA78023.1 - 2.8e-07 30.2 0.1 5.9e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EFA78023.1 - 0.0068 17.0 0.0 0.0068 17.0 0.0 3.4 3 1 0 3 3 3 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA78023.1 - 0.0072 16.4 0.0 0.027 14.6 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like CLN3 PF02487.17 EFA78023.1 - 0.035 13.2 13.8 0.022 13.8 0.7 2.9 2 1 1 3 3 3 0 CLN3 protein Rad60-SLD PF11976.8 EFA78023.1 - 0.036 13.9 0.8 0.17 11.8 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Pex16 PF08610.10 EFA78023.1 - 0.9 8.6 6.3 0.2 10.8 0.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) FNIP_N PF14636.6 EFA78024.1 - 3.7 8.5 18.0 4.5 8.2 18.0 1.1 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus EIIBC-GUT_N PF03612.14 EFA78024.1 - 5 6.8 9.9 7.9 6.2 0.6 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus EMP70 PF02990.16 EFA78025.1 - 4.6e-23 81.7 1.0 7.1e-23 81.1 1.0 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 RepC PF06504.11 EFA78025.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Replication protein C (RepC) EMP70 PF02990.16 EFA78026.1 - 5.9e-27 94.5 27.3 2.6e-26 92.4 27.3 1.9 1 1 0 1 1 1 1 Endomembrane protein 70 Ank_2 PF12796.7 EFA78027.1 - 9.9e-22 77.3 11.6 1.9e-06 28.4 0.4 6.1 4 2 3 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78027.1 - 1.2e-16 60.8 4.7 0.051 14.2 0.1 9.0 7 1 3 10 10 10 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78027.1 - 9.5e-15 53.3 0.9 0.061 13.9 0.0 9.2 11 0 0 11 11 11 2 Ankyrin repeat Ank_5 PF13857.6 EFA78027.1 - 9.8e-08 32.1 0.3 0.24 11.8 0.1 6.7 6 2 2 8 8 8 1 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA78027.1 - 0.002 18.0 0.1 4.3 7.3 0.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA78027.1 - 0.0072 16.7 0.1 7.2 7.2 0.0 5.0 6 1 0 6 6 6 1 Ankyrin repeat FBD PF08387.10 EFA78027.1 - 0.025 14.5 0.7 8.1 6.4 0.0 4.0 4 0 0 4 4 4 0 FBD L27 PF02828.16 EFA78027.1 - 0.12 12.2 0.2 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 L27 domain DUF4116 PF13475.6 EFA78027.1 - 0.16 11.7 6.1 6.1 6.7 0.0 4.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4116) Met_10 PF02475.16 EFA78027.1 - 0.26 11.0 2.5 12 5.6 1.4 3.2 2 1 0 2 2 2 0 Met-10+ like-protein DDE_Tnp_4 PF13359.6 EFA78028.1 - 8.9e-21 74.2 0.0 2.1e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease FNIP PF05725.12 EFA78028.1 - 2.5e-19 69.2 44.0 2.7e-09 37.0 5.7 10.9 7 3 6 13 13 13 10 FNIP Repeat DDE_Tnp_1 PF01609.21 EFA78028.1 - 1.2e-08 34.9 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain HTH_Tnp_4 PF13613.6 EFA78028.1 - 5.4e-05 22.8 0.2 0.00012 21.8 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease F-box_5 PF18511.1 EFA78028.1 - 0.00077 19.0 2.7 0.0019 17.7 2.7 1.6 1 0 0 1 1 1 1 F-box Opy2 PF09463.10 EFA78030.1 - 0.05 13.9 6.9 0.05 13.9 6.9 4.8 2 2 2 4 4 4 0 Opy2 protein Peptidase_S8 PF00082.22 EFA78031.1 - 4.7e-43 147.6 0.0 7.3e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 Subtilase family ABC_transp_aux PF09822.9 EFA78031.1 - 1.9e-05 24.3 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DUF4350 PF14258.6 EFA78031.1 - 0.11 12.9 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) DUF1067 PF06362.11 EFA78032.1 - 0.063 14.0 0.1 0.086 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1067) Adaptin_N PF01602.20 EFA78033.1 - 3e-105 352.8 12.9 2.3e-67 227.8 1.1 2.8 1 1 2 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 EFA78033.1 - 5.3e-52 176.1 4.0 7.5e-51 172.4 0.0 2.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA78033.1 - 6e-13 49.0 0.1 6.5e-05 23.2 0.0 4.4 3 1 1 4 4 4 3 HEAT repeats B2-adapt-app_C PF09066.10 EFA78033.1 - 1.2e-08 35.0 0.1 1.2e-08 35.0 0.1 1.9 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 EFA78033.1 - 3.9e-07 29.8 0.4 0.097 13.0 0.0 4.0 3 0 0 3 3 3 2 HEAT repeat CLASP_N PF12348.8 EFA78033.1 - 0.00057 19.5 0.4 0.84 9.1 0.0 2.9 2 1 0 2 2 2 2 CLASP N terminal RTP1_C1 PF10363.9 EFA78033.1 - 0.015 15.5 0.3 1.4 9.1 0.0 3.2 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EFA78033.1 - 0.03 14.3 2.0 23 5.2 0.0 4.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Roughex PF06020.11 EFA78033.1 - 3.2 6.7 6.2 5.5 6.0 6.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Pam16 PF03656.13 EFA78034.1 - 2.3e-08 34.1 0.1 5.6e-08 32.8 0.1 1.5 1 1 0 1 1 1 1 Pam16 DNA_binding_1 PF01035.20 EFA78035.1 - 3e-22 78.5 0.1 5.2e-22 77.8 0.1 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Usp PF00582.26 EFA78035.1 - 1.5e-12 48.2 0.0 3e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Universal stress protein family HDA2-3 PF11496.8 EFA78035.1 - 0.0016 17.7 0.6 0.0022 17.2 0.6 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Methyltransf_1N PF02870.15 EFA78035.1 - 0.0047 17.7 1.3 0.014 16.2 0.3 2.4 2 1 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Mucin PF01456.17 EFA78035.1 - 0.014 15.4 14.5 0.014 15.4 14.5 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Tir_receptor_C PF07489.11 EFA78035.1 - 6.3 6.7 21.6 1.6 8.6 3.4 2.3 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus PKcGMP_CC PF16808.5 EFA78036.1 - 9.2e-09 35.0 1.4 1.4e-05 24.9 0.2 3.5 2 1 1 3 3 3 3 Coiled-coil N-terminus of cGMP-dependent protein kinase MAD PF05557.13 EFA78036.1 - 1.1e-05 24.1 14.1 1.4e-05 23.7 14.1 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein Filament PF00038.21 EFA78036.1 - 2.9e-05 23.8 12.9 5.7e-05 22.9 12.9 1.5 1 0 0 1 1 1 1 Intermediate filament protein Golgin_A5 PF09787.9 EFA78036.1 - 0.00026 20.6 15.1 0.00035 20.2 15.1 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 CEP63 PF17045.5 EFA78036.1 - 0.00026 21.0 13.3 0.00037 20.5 12.8 1.5 1 1 0 1 1 1 1 Centrosomal protein of 63 kDa DUF641 PF04859.12 EFA78036.1 - 0.00057 20.2 14.3 0.012 15.9 5.3 2.3 1 1 1 2 2 2 2 Plant protein of unknown function (DUF641) TACC_C PF05010.14 EFA78036.1 - 0.00066 19.5 11.0 0.0011 18.8 11.0 1.4 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GAS PF13851.6 EFA78036.1 - 0.00066 19.1 15.5 0.0015 17.9 15.5 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding FPP PF05911.11 EFA78036.1 - 0.00068 18.0 13.5 0.0008 17.7 13.5 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Myosin_tail_1 PF01576.19 EFA78036.1 - 0.00071 17.5 8.5 0.0012 16.8 8.5 1.4 1 0 0 1 1 1 1 Myosin tail LMP PF04778.12 EFA78036.1 - 0.00096 19.1 7.3 0.00096 19.1 7.3 2.4 1 1 1 2 2 2 1 LMP repeated region DUF4407 PF14362.6 EFA78036.1 - 0.00096 18.6 7.2 0.0017 17.8 7.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF724 PF05266.14 EFA78036.1 - 0.0012 18.7 9.3 0.0025 17.7 9.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF724) TMF_DNA_bd PF12329.8 EFA78036.1 - 0.0018 18.2 23.1 0.023 14.7 7.3 2.9 2 1 1 3 3 2 2 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.11 EFA78036.1 - 0.0022 18.3 8.3 0.2 12.1 1.6 3.0 1 1 1 2 2 2 2 Flagella accessory protein C (FlaC) HOOK PF05622.12 EFA78036.1 - 0.0023 16.2 21.9 0.014 13.6 9.3 2.1 1 1 1 2 2 2 2 HOOK protein Exonuc_VII_L PF02601.15 EFA78036.1 - 0.0041 16.7 10.6 0.0057 16.3 10.6 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit ATG16 PF08614.11 EFA78036.1 - 0.0046 17.2 14.4 0.0088 16.3 14.4 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 EFA78036.1 - 0.005 16.9 3.7 0.005 16.9 3.7 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Yuri_gagarin PF15934.5 EFA78036.1 - 0.0062 16.4 10.8 0.011 15.6 10.8 1.5 1 0 0 1 1 1 1 Yuri gagarin HAUS-augmin3 PF14932.6 EFA78036.1 - 0.0067 16.0 13.9 0.0099 15.5 13.9 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 SlyX PF04102.12 EFA78036.1 - 0.0094 16.5 20.1 0.16 12.6 5.6 3.3 3 1 1 4 4 2 2 SlyX DUF3450 PF11932.8 EFA78036.1 - 0.011 15.1 15.2 0.057 12.7 14.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Csm1_N PF18504.1 EFA78036.1 - 0.011 16.0 17.5 0.22 11.9 4.7 3.0 1 1 2 3 3 2 0 Csm1 N-terminal domain Het-C PF07217.11 EFA78036.1 - 0.012 14.2 6.3 0.016 13.7 6.3 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C HAUS6_N PF14661.6 EFA78036.1 - 0.012 15.2 14.3 0.026 14.1 14.2 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus MPS2 PF17060.5 EFA78036.1 - 0.013 14.8 14.4 0.075 12.3 4.3 2.2 1 1 1 2 2 2 0 Monopolar spindle protein 2 Spc7 PF08317.11 EFA78036.1 - 0.014 14.3 17.3 0.049 12.5 17.3 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4201 PF13870.6 EFA78036.1 - 0.017 14.9 15.8 0.034 13.9 15.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) TolA_bind_tri PF16331.5 EFA78036.1 - 0.021 14.9 19.2 0.087 12.9 9.5 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation Sec2p PF06428.11 EFA78036.1 - 0.023 14.7 21.6 0.11 12.4 8.6 2.7 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Mst1_SARAH PF11629.8 EFA78036.1 - 0.031 14.4 8.1 0.076 13.1 3.9 3.1 1 1 2 3 3 3 0 C terminal SARAH domain of Mst1 FAM76 PF16046.5 EFA78036.1 - 0.031 13.6 18.4 0.045 13.1 17.4 1.8 1 1 0 1 1 1 0 FAM76 protein DUF4618 PF15397.6 EFA78036.1 - 0.033 13.6 18.8 0.2 11.0 4.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) HMMR_N PF15905.5 EFA78036.1 - 0.034 13.6 21.7 0.072 12.5 21.7 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Syntaxin-6_N PF09177.11 EFA78036.1 - 0.036 14.6 12.2 1.1 9.8 3.8 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Fez1 PF06818.15 EFA78036.1 - 0.039 14.4 14.2 0.12 12.8 14.3 1.6 1 1 0 1 1 1 0 Fez1 Fib_alpha PF08702.10 EFA78036.1 - 0.04 14.1 19.2 0.089 13.0 7.1 2.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family YjcZ PF13990.6 EFA78036.1 - 0.046 13.1 3.8 0.065 12.6 3.8 1.2 1 0 0 1 1 1 0 YjcZ-like protein Baculo_PEP_C PF04513.12 EFA78036.1 - 0.049 13.7 18.4 0.17 11.9 18.4 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_TATA_bd PF12325.8 EFA78036.1 - 0.053 13.7 12.8 0.11 12.7 12.3 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding LXG PF04740.12 EFA78036.1 - 0.06 13.0 12.6 0.11 12.2 12.6 1.4 1 0 0 1 1 1 0 LXG domain of WXG superfamily DUF3552 PF12072.8 EFA78036.1 - 0.083 12.3 14.3 0.15 11.5 14.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) COG2 PF06148.11 EFA78036.1 - 0.09 12.9 7.8 0.79 9.8 7.0 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FliJ PF02050.16 EFA78036.1 - 0.097 12.9 14.7 0.21 11.8 14.7 1.6 1 0 0 1 1 1 0 Flagellar FliJ protein KASH_CCD PF14662.6 EFA78036.1 - 0.1 12.4 21.5 1.5 8.6 7.3 2.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Prefoldin_2 PF01920.20 EFA78036.1 - 0.11 12.5 21.8 1.6 8.7 5.7 2.6 1 1 1 2 2 2 0 Prefoldin subunit OmpH PF03938.14 EFA78036.1 - 0.12 12.7 17.2 0.38 11.1 17.2 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) RPW8 PF05659.11 EFA78036.1 - 0.14 11.8 9.5 5.2 6.7 1.6 3.5 2 1 2 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 PspA_IM30 PF04012.12 EFA78036.1 - 0.15 11.6 14.2 0.39 10.3 4.8 2.1 1 1 2 3 3 3 0 PspA/IM30 family COG5 PF10392.9 EFA78036.1 - 0.16 12.2 11.8 4.2 7.6 11.8 2.7 2 1 0 2 2 2 0 Golgi transport complex subunit 5 TPD52 PF04201.15 EFA78036.1 - 0.16 11.6 9.2 0.26 10.9 9.2 1.5 1 1 0 1 1 1 0 Tumour protein D52 family UPF0242 PF06785.11 EFA78036.1 - 0.2 11.7 21.0 0.071 13.2 11.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ALMT PF11744.8 EFA78036.1 - 0.2 10.4 7.8 0.26 10.1 7.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Seryl_tRNA_N PF02403.22 EFA78036.1 - 0.21 11.8 16.3 0.3 11.3 13.7 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4226 PF10774.9 EFA78036.1 - 0.21 11.9 4.0 0.23 11.8 2.3 1.8 1 1 1 2 2 1 0 Domain of unknown function (DUF4226) Spc24 PF08286.11 EFA78036.1 - 0.23 11.7 18.6 0.26 11.6 6.3 2.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SpecificRecomb PF10136.9 EFA78036.1 - 0.25 9.6 4.5 0.34 9.2 4.5 1.1 1 0 0 1 1 1 0 Site-specific recombinase FliD_N PF02465.18 EFA78036.1 - 0.26 12.0 10.5 0.38 11.5 2.3 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF2203 PF09969.9 EFA78036.1 - 0.26 12.0 8.3 3.1 8.5 3.6 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) ABC_tran_CTD PF16326.5 EFA78036.1 - 0.32 11.3 12.5 18 5.7 9.1 3.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain Tweety PF04906.13 EFA78036.1 - 0.35 9.5 5.6 0.5 9.0 5.6 1.2 1 0 0 1 1 1 0 Tweety Lebercilin PF15619.6 EFA78036.1 - 0.45 10.2 23.6 9.7 5.8 22.6 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Angiomotin_C PF12240.8 EFA78036.1 - 0.59 9.7 11.7 0.21 11.1 2.7 2.2 1 1 1 2 2 2 0 Angiomotin C terminal DUF2730 PF10805.8 EFA78036.1 - 0.62 10.2 8.4 5.4 7.2 3.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) V_ATPase_I PF01496.19 EFA78036.1 - 0.63 7.9 10.0 0.82 7.5 10.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CC2-LZ PF16516.5 EFA78036.1 - 0.65 10.4 13.7 0.29 11.5 7.8 2.5 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Laminin_II PF06009.12 EFA78036.1 - 0.68 10.0 14.6 0.098 12.7 3.0 2.6 1 1 2 3 3 3 0 Laminin Domain II DUF812 PF05667.11 EFA78036.1 - 0.76 8.6 21.0 0.53 9.1 16.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Med4 PF10018.9 EFA78036.1 - 0.82 9.3 18.1 2.2 7.9 18.0 1.9 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF5082 PF16888.5 EFA78036.1 - 0.82 10.0 17.3 13 6.1 17.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DUF4298 PF14131.6 EFA78036.1 - 0.89 9.6 10.7 0.21 11.6 3.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) FapA PF03961.13 EFA78036.1 - 0.95 8.0 15.8 2.8 6.5 14.9 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A V-SNARE PF05008.15 EFA78036.1 - 1.1 9.7 14.6 0.54 10.7 6.5 2.8 1 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Cep57_MT_bd PF06657.13 EFA78036.1 - 1.1 9.7 13.2 1 9.9 6.4 3.5 2 1 2 4 4 3 0 Centrosome microtubule-binding domain of Cep57 Prominin PF05478.11 EFA78036.1 - 1.1 7.1 15.9 0.8 7.6 4.5 1.6 1 1 1 2 2 2 0 Prominin CENP-F_leu_zip PF10473.9 EFA78036.1 - 1.1 9.2 18.8 7.2 6.6 16.1 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Phage_GPO PF05929.11 EFA78036.1 - 1.4 8.5 13.6 1.1 8.8 3.7 2.2 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4404 PF14357.6 EFA78036.1 - 1.6 9.4 17.3 0.25 12.0 9.2 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) NPV_P10 PF05531.12 EFA78036.1 - 1.6 9.2 13.5 1.8e+02 2.6 13.5 2.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein LMBR1 PF04791.16 EFA78036.1 - 1.7 7.5 6.4 1.8 7.4 6.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Cluap1 PF10234.9 EFA78036.1 - 1.7 7.9 15.1 5.4 6.3 14.7 1.8 1 1 0 1 1 1 0 Clusterin-associated protein-1 Fzo_mitofusin PF04799.13 EFA78036.1 - 1.8 8.1 13.4 2.2 7.8 9.7 2.2 1 1 1 2 2 2 0 fzo-like conserved region Tropomyosin_1 PF12718.7 EFA78036.1 - 1.8 8.7 18.8 1.5 9.0 5.7 2.3 1 1 1 2 2 2 0 Tropomyosin like HemX PF04375.14 EFA78036.1 - 2.1 7.6 20.7 18 4.5 20.7 2.0 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Cortex-I_coil PF09304.10 EFA78036.1 - 2.6 8.3 13.2 1.1 9.4 2.2 2.7 1 1 1 2 2 2 0 Cortexillin I, coiled coil BST2 PF16716.5 EFA78036.1 - 2.8 8.6 23.1 2.3 8.9 10.4 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 HIP1_clath_bdg PF16515.5 EFA78036.1 - 2.8 8.6 19.1 1.7 9.3 6.9 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4527 PF15030.6 EFA78036.1 - 2.9 7.2 13.9 4.1 6.7 13.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4527) TMPIT PF07851.13 EFA78036.1 - 3.4 6.8 14.3 1 8.5 3.1 2.0 1 1 1 2 2 2 0 TMPIT-like protein YlqD PF11068.8 EFA78036.1 - 3.5 8.0 21.2 5.2 7.5 19.7 2.1 1 1 0 1 1 1 0 YlqD protein NYD-SP28 PF14772.6 EFA78036.1 - 3.6 7.7 16.2 11 6.1 3.4 2.7 1 1 1 2 2 2 0 Sperm tail DHR10 PF18595.1 EFA78036.1 - 4.1 7.5 21.5 3.8 7.6 11.7 2.5 2 1 1 3 3 2 0 Designed helical repeat protein 10 domain Sulfatase_C PF14707.6 EFA78036.1 - 4.1 8.1 7.4 7.4 7.3 1.4 2.4 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase BRE1 PF08647.11 EFA78036.1 - 4.6 7.4 20.1 0.47 10.6 4.3 3.0 2 1 1 3 3 2 0 BRE1 E3 ubiquitin ligase DUF948 PF06103.11 EFA78036.1 - 5.8 7.2 11.9 36 4.7 9.5 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DivIC PF04977.15 EFA78036.1 - 6.2 6.7 17.3 1.7 8.5 8.4 2.7 1 1 1 2 2 2 0 Septum formation initiator CENP-H PF05837.12 EFA78036.1 - 7.2 7.1 16.9 17 5.8 12.7 3.1 3 1 1 4 4 3 0 Centromere protein H (CENP-H) PCRF PF03462.18 EFA78036.1 - 9.5 6.0 13.6 22 4.8 11.4 2.3 1 1 2 3 3 3 0 PCRF domain Proteasome PF00227.26 EFA78038.1 - 0.00085 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Utp14 PF04615.13 EFA78039.1 - 0.01 14.5 52.4 0.013 14.1 52.4 1.1 1 0 0 1 1 1 0 Utp14 protein MAP7 PF05672.11 EFA78039.1 - 0.1 12.3 85.4 0.21 11.3 80.3 2.4 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Hamartin PF04388.12 EFA78039.1 - 1.6 7.3 48.4 2.3 6.8 48.4 1.3 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 EFA78039.1 - 2.4 5.2 49.0 3 4.9 49.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PRY PF13765.6 EFA78041.1 - 0.011 15.4 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 SPRY-associated domain Mrx7 PF10906.8 EFA78041.1 - 0.38 11.0 6.3 16 5.8 0.0 3.0 2 1 0 2 2 2 0 MIOREX complex component 7 Rxt3 PF08642.10 EFA78041.1 - 2 9.2 9.9 20 6.0 5.2 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF4607 PF15380.6 EFA78041.1 - 2.1 7.7 6.6 21 4.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4607) Roughex PF06020.11 EFA78041.1 - 2.4 7.2 11.0 4.4 6.3 11.0 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DAP3 PF10236.9 EFA78042.1 - 3.2e-28 98.8 0.2 1.6e-25 89.9 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 EFA78042.1 - 0.00034 20.6 0.1 0.0035 17.3 0.1 2.3 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFA78042.1 - 0.054 13.9 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFA78042.1 - 0.075 13.3 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFA78042.1 - 0.097 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF929 PF06053.11 EFA78044.1 - 0.0088 15.4 0.0 0.024 14.0 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF929) TRP PF06011.12 EFA78044.1 - 0.11 11.2 1.0 0.17 10.6 1.0 1.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel Conotoxin PF02950.17 EFA78044.1 - 0.19 12.8 8.1 3.5 8.7 7.4 2.7 2 1 0 2 2 2 0 Conotoxin SAYSvFN PF10260.9 EFA78044.1 - 0.39 10.7 1.5 3.9 7.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) Complex1_LYR PF05347.15 EFA78045.1 - 4.3e-17 61.9 2.5 4.3e-17 61.9 2.5 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFA78045.1 - 4.1e-09 37.1 1.6 4.1e-09 37.1 1.6 1.7 2 0 0 2 2 2 1 Complex1_LYR-like Synaphin PF05835.12 EFA78045.1 - 0.11 12.8 5.0 0.23 11.7 0.4 2.1 2 0 0 2 2 2 0 Synaphin protein Complex1_LYR_1 PF13232.6 EFA78045.1 - 0.18 12.4 3.1 1.3 9.7 3.3 2.4 1 1 0 1 1 1 0 Complex1_LYR-like UPF0728 PF15092.6 EFA78046.1 - 0.0037 17.1 2.0 2.8 7.8 0.3 3.6 3 0 0 3 3 3 2 Uncharacterised protein family UPF0728 DUF5315 PF17242.2 EFA78046.1 - 0.062 13.1 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 Disordered region of unknown function (DUF5315) Nucleoside_tran PF01733.18 EFA78047.1 - 3.9e-47 161.1 22.8 3.5e-45 154.7 22.4 2.2 1 1 0 1 1 1 1 Nucleoside transporter TRAP_alpha PF03896.16 EFA78047.1 - 0.036 13.3 0.0 0.058 12.6 0.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Phtf-FEM1B_bdg PF12129.8 EFA78047.1 - 0.51 10.2 2.3 0.45 10.3 0.5 1.8 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor tRNA-synt_1d PF00750.19 EFA78048.1 - 1.8e-104 349.5 1.9 2.3e-104 349.1 1.9 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFA78048.1 - 1.9e-21 76.5 0.1 4.5e-21 75.2 0.1 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFA78048.1 - 1e-10 42.1 0.4 3.9e-10 40.2 0.4 2.1 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain CAP PF00188.26 EFA78050.1 - 1.2e-09 39.1 0.1 1.2e-09 39.1 0.1 2.8 2 1 0 2 2 2 1 Cysteine-rich secretory protein family Utp14 PF04615.13 EFA78050.1 - 2.4 6.6 25.6 3.2 6.2 25.6 1.1 1 0 0 1 1 1 0 Utp14 protein Zip PF02535.22 EFA78051.1 - 1.9e-33 116.1 4.3 2.3e-33 115.8 4.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter FNIP PF05725.12 EFA78052.1 - 1.5e-05 25.0 0.1 1.6e-05 24.9 0.1 1.2 1 0 0 1 1 1 1 FNIP Repeat FNIP PF05725.12 EFA78053.1 - 3.9e-33 113.4 1.3 5.9e-13 48.8 0.0 3.7 1 1 3 4 4 4 4 FNIP Repeat SDA1 PF05285.12 EFA78053.1 - 0.48 9.8 25.7 0.57 9.6 25.7 1.1 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 EFA78053.1 - 0.91 9.1 20.9 1.3 8.5 20.9 1.3 1 0 0 1 1 1 0 PPP4R2 GMC_oxred_N PF00732.19 EFA78054.1 - 2.5e-39 135.4 0.0 5e-39 134.4 0.0 1.5 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA78054.1 - 4.1e-16 59.8 0.0 6.4e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EFA78054.1 - 0.00027 20.3 0.0 0.0039 16.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFA78054.1 - 0.0014 17.9 0.0 0.003 16.8 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EFA78054.1 - 0.004 17.4 0.0 0.0082 16.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFA78054.1 - 0.013 14.8 0.0 0.81 8.9 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA78054.1 - 0.035 13.2 0.0 0.051 12.6 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 EFA78054.1 - 0.039 13.6 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EFA78054.1 - 0.052 13.8 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.24 EFA78054.1 - 0.063 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EFA78054.1 - 0.14 10.9 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein SdrD_B PF17210.3 EFA78055.1 - 3e-14 53.2 0.6 5.7e-14 52.3 0.6 1.5 1 0 0 1 1 1 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA78055.1 - 1.3e-05 25.4 1.6 0.0002 21.5 1.7 2.5 2 1 0 2 2 2 1 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 EFA78056.1 - 3.8e-08 33.5 0.2 8.1e-08 32.5 0.2 1.6 1 0 0 1 1 1 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA78056.1 - 0.00041 20.6 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Beach PF02138.18 EFA78057.1 - 5e-126 419.7 0.9 1.2e-125 418.5 0.9 1.7 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 EFA78057.1 - 3.9e-15 56.0 16.8 0.0012 19.6 0.1 6.2 5 0 0 5 5 5 5 WD domain, G-beta repeat PH_BEACH PF14844.6 EFA78057.1 - 6.2e-10 39.1 0.0 6.2e-10 39.1 0.0 3.6 3 0 0 3 3 3 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 EFA78057.1 - 9.9e-09 34.8 1.3 4.1e-08 32.8 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4704) FixP_N PF14715.6 EFA78057.1 - 0.12 12.1 0.0 0.37 10.6 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP PEX11 PF05648.14 EFA78057.1 - 8.2 5.8 10.0 7.9 5.9 0.0 3.9 3 1 1 4 4 4 0 Peroxisomal biogenesis factor 11 (PEX11) RhoGEF PF00621.20 EFA78060.1 - 3.4e-38 131.7 0.8 3.4e-38 131.7 0.8 2.7 3 0 0 3 3 3 1 RhoGEF domain IQ PF00612.27 EFA78060.1 - 2.3e-05 23.8 1.8 3.4e-05 23.2 0.7 2.0 2 0 0 2 2 2 1 IQ calmodulin-binding motif IQ_SEC7_PH PF16453.5 EFA78060.1 - 0.0003 20.8 0.1 0.00087 19.3 0.1 1.7 1 0 0 1 1 1 1 PH domain zf-Di19 PF05605.12 EFA78060.1 - 0.073 13.4 0.2 0.19 12.1 0.2 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding AAA_33 PF13671.6 EFA78061.1 - 2.4e-06 27.8 0.0 0.0012 19.0 0.0 3.2 2 1 0 2 2 2 2 AAA domain KTI12 PF08433.10 EFA78061.1 - 0.00017 21.1 1.6 0.0035 16.8 1.5 2.8 1 1 0 1 1 1 1 Chromatin associated protein KTI12 DUF3439 PF11921.8 EFA78061.1 - 0.42 10.6 5.7 1 9.4 5.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 EFA78062.1 - 7.6e-63 212.3 0.0 1.4e-62 211.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78062.1 - 1.5e-34 119.4 0.0 2e-25 89.6 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase PH_3 PF14593.6 EFA78062.1 - 9e-28 96.4 0.3 2.3e-27 95.1 0.3 1.7 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EFA78062.1 - 5.3e-09 35.8 0.0 1.4e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFA78062.1 - 0.0078 15.6 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFA78062.1 - 0.04 13.5 0.1 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EFA78062.1 - 0.091 12.3 0.3 0.24 11.0 0.0 1.7 1 1 1 2 2 2 0 RIO1 family APH PF01636.23 EFA78062.1 - 0.2 11.6 0.0 0.33 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA78062.1 - 0.81 8.4 8.8 0.1 11.4 2.7 2.3 2 1 0 2 2 2 0 Fungal protein kinase Ribosomal_L29e PF01779.17 EFA78063.1 - 3.9e-17 62.3 9.9 3.9e-17 62.3 9.9 2.1 2 0 0 2 2 2 1 Ribosomal L29e protein family SpmSyn_N PF17950.1 EFA78063.1 - 0.067 13.4 0.0 0.075 13.2 0.0 1.1 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase N -terminal Rhomboid PF01694.22 EFA78066.1 - 1e-18 67.8 13.7 1.1e-18 67.6 12.0 1.8 2 0 0 2 2 2 1 Rhomboid family AP-5_subunit_s1 PF15001.6 EFA78066.1 - 0.0032 17.5 1.6 0.0054 16.7 1.6 1.3 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 MORN PF02493.20 EFA78066.1 - 0.0046 16.8 0.5 0.022 14.6 0.3 2.3 2 0 0 2 2 2 1 MORN repeat SR-25 PF10500.9 EFA78066.1 - 0.11 12.0 8.4 0.16 11.6 8.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EFA78066.1 - 2.2 9.0 8.5 4 8.2 8.5 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein F-box PF00646.33 EFA78068.1 - 0.019 14.8 0.2 0.072 13.0 0.1 2.0 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EFA78068.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 F-box-like SURF2 PF05477.11 EFA78068.1 - 0.13 12.0 7.7 0.22 11.2 7.7 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) FAM176 PF14851.6 EFA78068.1 - 0.55 9.9 4.3 0.94 9.1 4.3 1.4 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EFA78068.1 - 1.2 8.4 9.9 1.8 7.8 9.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4637 PF15470.6 EFA78068.1 - 1.4 8.6 7.0 2.4 7.9 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) ASF1_hist_chap PF04729.13 EFA78069.1 - 1e-48 165.2 0.1 1.2e-48 165.0 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Thiolase_N PF00108.23 EFA78071.1 - 6.7e-88 294.4 0.5 1.3e-87 293.5 0.5 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFA78071.1 - 1.3e-45 154.0 1.3 9.5e-45 151.2 0.6 2.4 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFA78071.1 - 9.7e-06 25.3 0.6 0.00031 20.4 0.5 2.6 1 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain NAC PF01849.18 EFA78071.1 - 0.049 13.6 0.4 18 5.4 0.0 3.4 3 0 0 3 3 3 0 NAC domain DUF1847 PF08901.11 EFA78071.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1847) DUF348 PF03990.14 EFA78071.1 - 0.17 11.7 0.5 4.8 7.0 0.1 2.5 2 0 0 2 2 2 0 G5-linked-Ubiquitin-like domain Ketoacyl-synt_C PF02801.22 EFA78071.1 - 0.17 11.9 1.9 26 4.9 0.0 3.4 4 0 0 4 4 4 0 Beta-ketoacyl synthase, C-terminal domain DUF3699 PF12480.8 EFA78072.1 - 0.04 14.1 0.0 0.059 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3699) Pkinase PF00069.25 EFA78073.1 - 5.8e-08 32.4 0.0 7.1e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78073.1 - 1.4e-06 27.8 0.0 1.7e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_transf_11 PF01531.16 EFA78073.1 - 0.039 13.1 0.3 0.045 13.0 0.3 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 11 DUF2552 PF10827.8 EFA78074.1 - 0.067 13.4 0.2 0.31 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2552) ETS_PEA3_N PF04621.13 EFA78075.1 - 0.00063 19.7 5.5 0.0016 18.4 5.5 1.7 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain zf-UBR PF02207.20 EFA78075.1 - 0.002 18.2 12.0 0.002 18.2 12.0 3.6 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) Nop14 PF04147.12 EFA78075.1 - 0.07 11.3 6.5 0.12 10.5 6.5 1.3 1 0 0 1 1 1 0 Nop14-like family DUF3439 PF11921.8 EFA78075.1 - 0.14 12.1 6.9 0.58 10.1 6.9 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DIOX_N PF14226.6 EFA78076.1 - 5.4e-32 111.0 0.0 8.1e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFA78076.1 - 1.8e-22 79.7 0.0 3.7e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GST_N PF02798.20 EFA78077.1 - 2.2e-11 43.9 1.4 2.8e-11 43.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA78077.1 - 1.5e-09 38.1 0.0 3e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA78077.1 - 1.2e-07 31.8 0.0 2.5e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFA78077.1 - 4.1e-07 30.2 0.0 8.5e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA78077.1 - 8.4e-06 25.9 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA78077.1 - 0.00085 19.3 0.1 0.0018 18.3 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4834 PF16118.5 EFA78077.1 - 0.0049 17.8 0.1 0.0062 17.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 EFA78077.1 - 0.037 14.8 7.5 0.07 14.0 7.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 RP-C_C PF11800.8 EFA78077.1 - 0.071 13.2 4.1 0.097 12.8 4.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region CPSF100_C PF13299.6 EFA78077.1 - 0.43 10.7 3.3 0.6 10.3 3.3 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peroxin-13_N PF04088.13 EFA78077.1 - 0.44 10.8 1.7 0.83 9.9 1.7 1.5 1 1 0 1 1 1 0 Peroxin 13, N-terminal region Ctr PF04145.15 EFA78077.1 - 0.44 11.2 3.5 0.82 10.3 3.5 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Presenilin PF01080.17 EFA78077.1 - 1 8.1 6.7 1.3 7.7 6.7 1.1 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 EFA78077.1 - 1.4 7.9 2.6 1.8 7.5 2.6 1.1 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 EFA78077.1 - 5.5 5.7 7.3 8.5 5.1 7.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Orf78 PF06024.12 EFA78077.1 - 5.6 7.3 6.0 9.6 6.6 6.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Peptidase_M20 PF01546.28 EFA78078.1 - 2.2e-33 115.7 0.0 2.7e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA78078.1 - 2.1e-20 72.6 0.0 8.2e-20 70.8 0.0 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFA78078.1 - 0.0032 17.2 0.0 0.031 14.0 0.0 2.1 1 1 1 2 2 2 1 Peptidase family M28 Methyltransf_16 PF10294.9 EFA78079.1 - 2.4e-16 60.0 0.1 2.4e-16 60.0 0.1 2.2 1 1 1 2 2 2 1 Lysine methyltransferase Methyltransf_31 PF13847.6 EFA78079.1 - 2.9e-12 46.6 0.2 1.6e-11 44.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA78079.1 - 2.4e-10 40.5 0.0 6.6e-10 39.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA78079.1 - 6e-09 36.4 0.0 1.3e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA78079.1 - 1.5e-08 35.3 3.0 4.2e-07 30.6 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA78079.1 - 3.9e-08 33.9 0.0 6.8e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA78079.1 - 2.2e-05 24.1 0.0 0.00021 20.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 EFA78079.1 - 0.00011 22.0 0.0 0.0002 21.1 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 TehB PF03848.14 EFA78079.1 - 0.00014 21.4 0.2 0.00014 21.4 0.2 2.0 2 0 0 2 2 2 1 Tellurite resistance protein TehB ESM4 PF15952.5 EFA78079.1 - 0.073 13.5 8.5 0.087 13.2 7.9 1.4 1 1 0 1 1 1 0 Enhancer of split M4 family NodS PF05401.11 EFA78079.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.4 1 1 0 1 1 1 0 Nodulation protein S (NodS) TIG PF01833.24 EFA78080.1 - 0.00013 21.9 1.8 0.00013 21.9 1.8 4.5 4 1 1 5 5 5 1 IPT/TIG domain EB PF01683.18 EFA78080.1 - 0.0019 18.4 4.1 0.0062 16.8 4.1 1.8 1 0 0 1 1 1 1 EB module hEGF PF12661.7 EFA78080.1 - 0.0056 17.3 7.1 0.023 15.3 7.1 2.2 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.13 EFA78080.1 - 0.083 13.3 14.0 0.18 12.2 14.0 1.6 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 EFA78080.1 - 0.12 12.7 10.5 0.32 11.4 10.5 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFA78080.1 - 2.1 8.5 5.6 5.4 7.2 5.6 1.7 1 0 0 1 1 1 0 Tenascin EGF domain HTH_ParB PF17762.1 EFA78082.1 - 0.014 15.2 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 HTH domain found in ParB protein COMM_domain PF07258.14 EFA78083.1 - 0.013 15.6 9.9 0.027 14.6 4.2 3.6 3 0 0 3 3 3 0 COMM domain Hit1_C PF18268.1 EFA78083.1 - 2.1 8.6 7.9 0.26 11.5 0.4 3.2 2 2 1 3 3 3 0 Hit1 C-terminal DUF1189 PF06691.11 EFA78083.1 - 4.3 6.8 11.4 8.9 5.8 11.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) RNA_pol_Rpb1_1 PF04997.12 EFA78084.1 - 4.3e-116 387.6 0.5 4.3e-116 387.6 0.5 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EFA78084.1 - 7.2e-109 363.3 0.0 2.2e-108 361.7 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFA78084.1 - 3.7e-77 258.2 0.7 1.2e-76 256.6 0.1 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EFA78084.1 - 4.3e-57 193.0 0.4 1e-56 191.8 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EFA78084.1 - 1.9e-50 170.9 0.0 4.9e-50 169.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EFA78084.1 - 4.2e-45 153.1 3.9 1.4e-44 151.4 3.9 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 C12orf66_like PF09404.10 EFA78084.1 - 8.7e-43 146.8 9.5 1.7e-41 142.5 9.5 2.2 1 1 0 1 1 1 1 KICSTOR complex C12orf66 like RNA_pol_Rpb1_4 PF05000.17 EFA78084.1 - 1.9e-38 130.7 0.7 6.6e-38 129.0 0.7 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EFA78084.1 - 0.0011 19.3 306.9 2.1 8.9 18.2 13.8 14 0 0 14 14 14 11 RNA polymerase Rpb1 C-terminal repeat ISN1 PF06437.11 EFA78084.1 - 0.058 12.3 0.4 0.1 11.4 0.4 1.3 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase DUF4748 PF15932.5 EFA78085.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Pept_tRNA_hydro PF01195.19 EFA78086.1 - 3.3e-16 59.7 0.0 4.6e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Aconitase_C PF00694.19 EFA78086.1 - 0.13 12.6 0.1 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Aconitase C-terminal domain Pex14_N PF04695.13 EFA78087.1 - 0.28 11.8 17.1 0.27 11.9 5.6 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 EFA78087.1 - 8 6.3 25.4 3.8 7.4 13.2 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TFIIS_C PF01096.18 EFA78089.1 - 5e-17 61.5 3.2 5e-17 61.5 3.2 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Utp14 PF04615.13 EFA78089.1 - 2.7e-05 23.0 60.7 2.8e-05 22.9 60.7 1.1 1 0 0 1 1 1 1 Utp14 protein Zn_Tnp_IS1595 PF12760.7 EFA78089.1 - 0.0017 18.3 6.9 0.011 15.7 1.2 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 EFA78089.1 - 0.0017 18.2 10.9 0.026 14.4 2.2 3.6 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 EFA78089.1 - 0.018 15.1 9.3 0.093 12.8 0.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon Ogr_Delta PF04606.12 EFA78089.1 - 0.027 14.5 3.3 0.027 14.5 3.3 3.3 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zf-ribbon_3 PF13248.6 EFA78089.1 - 0.054 12.9 4.1 4.2 6.9 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Baculo_LEF5_C PF11792.8 EFA78089.1 - 0.082 12.6 0.4 0.18 11.5 0.4 1.6 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain LRV_FeS PF05484.11 EFA78089.1 - 0.14 12.2 2.1 9.9 6.3 0.0 3.1 3 0 0 3 3 3 0 LRV protein FeS4 cluster DNA_RNApol_7kD PF03604.13 EFA78089.1 - 0.22 11.2 5.7 3.9 7.2 0.2 3.5 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_9 PF14369.6 EFA78089.1 - 0.44 10.9 2.8 22 5.4 0.0 2.9 3 0 0 3 3 3 0 zinc-ribbon Zn-ribbon_8 PF09723.10 EFA78089.1 - 0.64 10.2 14.4 15 5.8 1.3 4.3 3 1 1 4 4 4 0 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 EFA78089.1 - 1.5 8.9 4.9 8.2 6.6 0.1 2.8 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C4_Topoisom PF01396.19 EFA78089.1 - 3 7.7 10.0 16 5.4 1.0 3.4 2 1 1 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Rubredoxin PF00301.20 EFA78089.1 - 6 7.0 7.5 29 4.8 0.1 3.9 4 0 0 4 4 4 0 Rubredoxin Ribosomal_S27e PF01667.17 EFA78089.1 - 8.5 6.2 8.4 10 5.9 1.9 3.0 2 1 0 2 2 2 0 Ribosomal protein S27 Thg1 PF04446.12 EFA78090.1 - 2.4e-36 124.5 0.1 3.2e-36 124.1 0.1 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Usp PF00582.26 EFA78091.1 - 3.3e-22 79.5 0.0 1.5e-21 77.4 0.0 1.8 1 1 0 1 1 1 1 Universal stress protein family Ald_deCOase PF11266.8 EFA78091.1 - 0.029 14.1 0.1 0.042 13.5 0.1 1.2 1 0 0 1 1 1 0 Long-chain fatty aldehyde decarbonylase UvrB_inter PF17757.1 EFA78091.1 - 0.05 13.8 0.3 0.16 12.2 0.1 1.8 1 1 1 2 2 2 0 UvrB interaction domain FTHFS PF01268.19 EFA78092.1 - 1.7e-197 657.0 2.2 5.4e-172 572.9 0.2 3.0 1 1 2 3 3 3 3 Formate--tetrahydrofolate ligase DUF3682 PF12446.8 EFA78093.1 - 0.013 16.0 7.1 0.013 16.0 7.1 7.1 6 1 1 7 7 7 0 Protein of unknown function (DUF3682) RPAP1_C PF08620.10 EFA78094.1 - 1.9e-23 82.4 0.0 4.9e-23 81.0 0.0 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EFA78094.1 - 3.1e-13 49.3 5.4 9.4e-13 47.7 5.4 1.9 1 0 0 1 1 1 1 RPAP1-like, N-terminal TauE PF01925.19 EFA78095.1 - 0.0073 16.0 0.2 0.0085 15.7 0.2 1.2 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE CD20 PF04103.15 EFA78096.1 - 6.5 6.8 8.6 53 3.9 0.6 4.3 4 1 1 5 5 5 0 CD20-like family BB_PF PF18063.1 EFA78098.1 - 3.6e-34 118.2 4.5 4.9e-34 117.7 4.5 1.1 1 0 0 1 1 1 1 Beta barrel Pore-forming domain Pkinase PF00069.25 EFA78100.1 - 4.1e-77 259.1 0.3 1.2e-76 257.6 0.3 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78100.1 - 1.1e-37 129.7 0.0 2.3e-37 128.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA78100.1 - 7e-09 35.4 0.0 1.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFA78100.1 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA78100.1 - 0.0024 17.8 0.0 0.0056 16.6 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pinin_SDK_memA PF04696.13 EFA78100.1 - 0.11 12.6 27.3 0.39 10.8 27.3 2.0 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Peptidase_S49_N PF08496.10 EFA78100.1 - 4.8 7.2 15.0 14 5.7 15.0 2.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ric8 PF10165.9 EFA78101.1 - 2.7e-23 82.8 0.0 1.9e-22 79.9 0.0 2.0 1 1 1 2 2 2 2 Guanine nucleotide exchange factor synembryn NADPH_Ox PF08414.10 EFA78101.1 - 0.14 12.5 0.1 0.3 11.5 0.1 1.5 1 0 0 1 1 1 0 Respiratory burst NADPH oxidase Cut8 PF08559.10 EFA78102.1 - 1.5e-21 77.1 0.4 1.6e-15 57.4 0.2 2.1 2 0 0 2 2 2 2 Cut8, nuclear proteasome tether protein DUF4746 PF15928.5 EFA78102.1 - 0.0025 17.3 5.2 0.0037 16.7 5.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) PBP1_TM PF14812.6 EFA78102.1 - 0.0038 17.6 2.9 0.0073 16.6 2.9 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal THOC2_N PF16134.5 EFA78102.1 - 0.0068 15.1 0.3 0.0075 15.0 0.3 1.1 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus DUF3391 PF11871.8 EFA78102.1 - 0.022 15.3 3.2 0.035 14.6 3.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) GEN1_C PF18380.1 EFA78102.1 - 0.077 13.9 4.4 0.16 12.8 4.4 1.5 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain CDC45 PF02724.14 EFA78102.1 - 1.6 7.0 8.6 2.1 6.5 8.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EFA78102.1 - 2.9 5.9 9.6 0.29 9.2 5.2 1.6 2 0 0 2 2 2 0 DNA polymerase phi FAM176 PF14851.6 EFA78102.1 - 3 7.5 6.9 5.4 6.7 6.9 1.3 1 0 0 1 1 1 0 FAM176 family Methyltransf_11 PF08241.12 EFA78103.1 - 6.9e-15 55.5 0.0 1.2e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA78103.1 - 8.2e-14 52.1 0.0 6.7e-13 49.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA78103.1 - 9.3e-10 38.5 0.2 1.1e-09 38.2 0.2 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA78103.1 - 1.3e-06 27.9 0.2 2.4e-06 27.1 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFA78103.1 - 0.00016 21.6 0.0 0.00023 21.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA78103.1 - 0.00042 19.9 0.0 0.00062 19.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFA78103.1 - 0.0048 16.3 0.0 0.0078 15.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 EFA78103.1 - 0.016 14.3 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF688 PF05097.12 EFA78103.1 - 2 7.5 7.9 2.9 6.9 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF688) DNA_pol_phi PF04931.13 EFA78103.1 - 3.8 5.5 12.3 4.8 5.1 12.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi NFACT-R_1 PF05670.13 EFA78104.1 - 3.2e-44 150.1 0.5 6.5e-44 149.0 0.0 1.7 2 0 0 2 2 2 1 NFACT protein RNA binding domain DUF1682 PF07946.14 EFA78104.1 - 0.078 12.2 10.5 0.1 11.8 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SDA1 PF05285.12 EFA78105.1 - 0.053 12.9 25.1 0.065 12.6 25.1 1.2 1 0 0 1 1 1 0 SDA1 DUF4140 PF13600.6 EFA78105.1 - 0.31 11.5 2.8 12 6.4 0.0 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Chibby PF14645.6 EFA78105.1 - 1 9.8 17.3 9.5 6.7 17.3 2.7 1 1 0 1 1 1 0 Chibby family TFIIF_alpha PF05793.12 EFA78105.1 - 1.1 7.8 32.2 1.6 7.2 32.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ndc1_Nup PF09531.10 EFA78105.1 - 9 4.8 11.9 12 4.4 11.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3965 PF13112.6 EFA78106.1 - 0.033 13.4 0.2 0.038 13.2 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) GHL13 PF14883.6 EFA78107.1 - 0.02 14.0 1.1 0.038 13.0 1.1 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 bZIP_2 PF07716.15 EFA78107.1 - 0.5 10.5 10.6 27 4.9 0.0 2.6 2 0 0 2 2 2 0 Basic region leucine zipper HALZ PF02183.18 EFA78107.1 - 1.2 9.4 9.1 5.2 7.4 0.4 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper I_LWEQ PF01608.17 EFA78109.1 - 1.7e-72 242.7 200.4 8.8e-47 159.2 11.8 19.9 5 4 16 21 21 20 16 I/LWEQ domain FERM_f0 PF16511.5 EFA78109.1 - 2.5e-29 101.4 0.1 9e-26 90.0 0.0 3.1 2 0 0 2 2 2 2 N-terminal or F0 domain of Talin-head FERM FERM_M PF00373.18 EFA78109.1 - 7.3e-27 94.1 4.0 1.8e-26 92.8 0.1 3.8 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.10 EFA78109.1 - 4.9e-17 61.6 0.1 2.3e-16 59.5 0.1 2.2 2 0 0 2 2 2 1 FERM N-terminal domain VHP PF02209.19 EFA78109.1 - 6.9e-14 51.6 0.9 6.9e-14 51.6 0.9 2.1 2 0 0 2 2 2 1 Villin headpiece domain VBS PF08913.10 EFA78109.1 - 2e-05 25.1 117.0 0.001 19.5 6.2 13.7 13 4 1 14 14 14 5 Vinculin Binding Site DUF2935 PF11155.8 EFA78109.1 - 0.98 9.8 8.9 23 5.3 0.4 6.7 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) Ank_2 PF12796.7 EFA78110.1 - 7.4e-28 97.0 8.1 0.00018 22.0 0.1 6.7 3 3 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78110.1 - 4.3e-23 81.4 16.2 0.0019 18.7 0.1 10.1 5 3 4 9 9 9 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78110.1 - 2.3e-22 78.7 9.2 0.092 13.1 0.0 12.3 6 3 7 13 13 13 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78110.1 - 2.4e-14 52.0 10.7 0.37 11.5 0.1 10.8 11 1 1 12 12 12 3 Ankyrin repeat DUF5049 PF16468.5 EFA78110.1 - 2.8e-05 23.9 1.3 0.85 9.6 0.0 5.2 6 0 0 6 6 6 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA78110.1 - 7.7e-05 23.0 5.2 11 6.7 0.0 7.0 5 1 0 5 5 5 1 Ankyrin repeat Helicase_PWI PF18149.1 EFA78110.1 - 0.00051 20.2 0.2 0.12 12.5 0.0 4.1 3 1 1 4 4 4 1 N-terminal helicase PWI domain DUF1843 PF08898.10 EFA78110.1 - 0.0023 18.4 0.0 4.2 8.0 0.0 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF1843) ENTH PF01417.20 EFA78110.1 - 0.0054 16.8 2.5 6 6.9 0.5 4.8 4 2 2 6 6 6 1 ENTH domain DDE_1 PF03184.19 EFA78111.1 - 8.2e-12 45.1 0.9 1.7e-11 44.1 0.9 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 EFA78111.1 - 0.0019 17.9 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_19 PF12844.7 EFA78111.1 - 0.0095 15.9 1.2 0.089 12.8 0.4 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_37 PF13744.6 EFA78111.1 - 0.022 14.7 0.2 0.055 13.4 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 EFA78111.1 - 0.026 14.6 0.1 0.27 11.3 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix Abp2 PF09441.10 EFA78111.1 - 0.043 13.9 0.2 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 ARS binding protein 2 HTH_24 PF13412.6 EFA78111.1 - 0.12 12.0 0.0 0.78 9.4 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Afi1 PF07792.12 EFA78112.1 - 0.0044 17.5 2.2 0.011 16.2 2.2 1.7 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Nop14 PF04147.12 EFA78112.1 - 0.67 8.1 11.4 1 7.5 11.4 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EFA78112.1 - 1.6 8.7 10.6 3.3 7.7 10.6 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal RHD3 PF05879.12 EFA78113.1 - 1.2e-196 655.2 11.7 1.4e-196 655.0 11.7 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EFA78113.1 - 1.3e-06 28.4 0.0 5.2e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFA78113.1 - 0.0019 18.3 3.9 0.0019 18.2 0.1 2.7 2 1 0 2 2 2 1 Dynamin family AAA_28 PF13521.6 EFA78113.1 - 0.0028 17.9 0.1 0.014 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFA78113.1 - 0.037 14.5 1.8 0.06 13.9 0.0 2.2 2 1 0 2 2 2 0 ABC transporter DUF2774 PF11242.8 EFA78113.1 - 0.06 13.6 0.1 0.19 11.9 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) AAA_14 PF13173.6 EFA78113.1 - 0.067 13.2 0.0 0.25 11.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA78113.1 - 0.078 13.4 0.2 1 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain CdiI_2 PF18593.1 EFA78113.1 - 0.088 13.5 3.0 0.18 12.5 0.1 3.1 3 0 0 3 3 3 0 CdiI immunity protein RsgA_GTPase PF03193.16 EFA78113.1 - 0.11 12.3 0.0 0.43 10.5 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase Atypical_Card PF18461.1 EFA78113.1 - 1.6 9.0 4.5 9 6.6 0.1 4.1 5 1 0 5 5 5 0 Atypical caspase recruitment domain YtxH PF12732.7 EFA78113.1 - 2.1 8.9 5.4 14 6.3 0.8 3.7 1 1 1 2 2 2 0 YtxH-like protein ALG3 PF05208.13 EFA78114.1 - 2.5e-53 181.8 27.5 5.1e-53 180.8 27.5 1.4 1 0 0 1 1 1 1 ALG3 protein WD40 PF00400.32 EFA78114.1 - 0.055 14.4 0.1 0.48 11.4 0.2 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat Squash PF00299.18 EFA78115.1 - 0.053 13.6 0.7 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 Squash family serine protease inhibitor MobC PF05713.11 EFA78115.1 - 6.6 7.3 5.9 16 6.1 5.9 1.6 1 0 0 1 1 1 0 Bacterial mobilisation protein (MobC) Beta_helix PF13229.6 EFA78116.1 - 0.00029 20.7 22.4 0.00029 20.7 22.4 3.5 1 1 2 3 3 3 1 Right handed beta helix region Syndecan PF01034.20 EFA78116.1 - 0.012 15.5 0.8 0.027 14.4 0.8 1.6 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.15 EFA78116.1 - 0.033 14.0 0.8 0.064 13.0 0.8 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4690 PF15756.5 EFA78116.1 - 0.06 13.9 0.1 0.16 12.6 0.1 1.6 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Kelch_6 PF13964.6 EFA78118.1 - 7.3e-09 35.6 4.9 3.4e-05 24.0 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA78118.1 - 0.0026 17.3 0.3 0.0026 17.3 0.3 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 EFA78118.1 - 0.0064 16.4 3.3 0.3 11.1 0.1 3.1 2 0 0 2 2 2 1 Kelch motif zf-B_box PF00643.24 EFA78118.1 - 0.01 16.0 6.8 0.01 16.0 6.8 2.2 2 0 0 2 2 2 0 B-box zinc finger Mur_ligase_M PF08245.12 EFA78118.1 - 0.031 14.3 2.6 0.11 12.5 2.6 1.9 1 0 0 1 1 1 0 Mur ligase middle domain Zf_RING PF16744.5 EFA78118.1 - 1.4 9.1 6.6 1.7 8.8 3.3 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger Neisseria_TspB PF05616.13 EFA78119.1 - 0.0097 14.4 0.0 0.01 14.4 0.0 1.2 1 0 0 1 1 1 1 Neisseria meningitidis TspB protein RF3_C PF16658.5 EFA78119.1 - 0.056 13.3 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFA78120.1 - 4.3e-39 133.7 0.0 7.9e-39 132.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFA78120.1 - 6.1e-38 130.4 0.1 4.3e-37 127.6 0.1 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFA78120.1 - 3.4e-28 97.7 0.2 7.4e-28 96.6 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFA78120.1 - 1.3e-11 44.9 0.0 4.9e-11 43.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EFA78120.1 - 0.0005 19.8 0.1 0.0023 17.6 0.1 2.1 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal PIN_6 PF17146.4 EFA78121.1 - 4.7e-26 91.1 0.3 1.5e-25 89.5 0.3 2.0 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EFA78121.1 - 2.5e-18 66.0 2.2 2.5e-18 66.0 2.2 2.3 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like Beta_helix PF13229.6 EFA78121.1 - 0.0013 18.6 23.2 0.0013 18.6 23.2 5.1 1 1 4 5 5 5 4 Right handed beta helix region Squash PF00299.18 EFA78121.1 - 0.03 14.4 0.0 0.093 12.8 0.0 1.8 1 0 0 1 1 1 0 Squash family serine protease inhibitor Beta_helix PF13229.6 EFA78122.1 - 0.0063 16.4 26.8 0.0063 16.4 26.8 3.2 1 1 1 2 2 2 1 Right handed beta helix region Syndecan PF01034.20 EFA78122.1 - 0.014 15.3 0.9 0.033 14.1 0.9 1.6 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.15 EFA78122.1 - 0.023 14.5 0.7 0.045 13.5 0.7 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4690 PF15756.5 EFA78122.1 - 0.038 14.6 0.1 0.11 13.1 0.1 1.7 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DUF1565 PF07602.11 EFA78123.1 - 0.058 12.7 0.0 0.058 12.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1565) Palm_thioest PF02089.15 EFA78126.1 - 4.2e-86 288.7 0.0 5.8e-86 288.3 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase UAA PF08449.11 EFA78126.1 - 1.1e-62 211.9 23.7 2e-62 211.2 23.7 1.3 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EFA78126.1 - 0.001 18.3 4.1 0.0013 17.9 3.4 1.4 1 1 0 1 1 1 1 Nucleotide-sugar transporter Oxidored_q2 PF00420.24 EFA78126.1 - 0.0024 17.5 3.5 0.02 14.5 2.0 2.7 2 0 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF915 PF06028.11 EFA78126.1 - 0.11 11.8 0.0 0.28 10.5 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) EamA PF00892.20 EFA78126.1 - 8.9 6.5 25.1 0.1 12.8 14.9 2.6 3 0 0 3 3 3 0 EamA-like transporter family zf-Sec23_Sec24 PF04810.15 EFA78127.1 - 1.8e-09 37.5 0.1 6.3e-09 35.7 0.1 2.0 1 1 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EFA78127.1 - 4.3e-09 37.0 0.1 1.3e-08 35.5 0.1 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EFA78127.1 - 0.001 18.9 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EFA78127.1 - 0.042 13.2 2.9 0.27 10.6 0.1 3.0 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF1803 PF08820.10 EFA78127.1 - 0.17 12.0 1.4 0.94 9.5 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) Mucin PF01456.17 EFA78127.1 - 1.6 8.8 7.2 3.4 7.7 7.2 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein SDF PF00375.18 EFA78128.1 - 0.011 14.8 0.2 0.013 14.5 0.2 1.1 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family Pet20 PF08692.10 EFA78128.1 - 0.075 13.7 0.5 0.085 13.6 0.5 1.0 1 0 0 1 1 1 0 Mitochondrial protein Pet20 EVI2A PF05399.11 EFA78129.1 - 0.11 12.0 6.9 0.24 10.9 6.9 1.5 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DHR-2 PF06920.13 EFA78130.1 - 5.7e-174 579.6 6.0 7.7e-174 579.2 6.0 1.1 1 0 0 1 1 1 1 Dock homology region 2 RIX1 PF08167.12 EFA78130.1 - 0.1 12.3 3.2 0.51 10.0 0.0 2.9 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis DUF3398 PF11878.8 EFA78131.1 - 5.2e-08 33.3 0.8 2.2e-07 31.3 0.8 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) DOCK-C2 PF14429.6 EFA78131.1 - 0.0015 18.3 3.8 0.32 10.8 0.0 3.5 2 1 1 3 3 3 2 C2 domain in Dock180 and Zizimin proteins MFS_2 PF13347.6 EFA78132.1 - 6e-80 268.9 13.2 5.3e-53 180.1 9.4 2.0 1 1 1 2 2 2 2 MFS/sugar transport protein PUCC PF03209.15 EFA78132.1 - 7.7e-06 25.1 1.6 1.5e-05 24.2 1.6 1.6 1 0 0 1 1 1 1 PUCC protein DUF4419 PF14388.6 EFA78133.1 - 5.7e-89 298.5 1.3 7.5e-89 298.1 1.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) DUF4419 PF14388.6 EFA78134.1 - 1.3e-96 323.6 1.1 1.7e-96 323.3 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) MFS_1 PF07690.16 EFA78135.1 - 7.4e-12 44.8 15.6 8.9e-11 41.3 10.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFA78135.1 - 3.1e-08 32.6 10.9 3.1e-08 32.6 10.9 1.9 1 1 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 EFA78135.1 - 2.4e-07 30.0 0.2 0.00042 19.3 0.8 2.6 2 1 1 3 3 3 2 MFS_1 like family Sugar_tr PF00083.24 EFA78135.1 - 1.7e-05 23.9 12.4 4.4e-05 22.5 12.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter PUCC PF03209.15 EFA78135.1 - 0.002 17.2 4.0 0.0028 16.7 4.0 1.3 1 0 0 1 1 1 1 PUCC protein Rad60-SLD PF11976.8 EFA78136.1 - 3e-18 65.4 3.2 1.1e-11 44.4 0.2 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFA78136.1 - 5.1e-05 22.9 2.4 0.0064 16.2 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin family Macoilin PF09726.9 EFA78136.1 - 0.41 9.1 23.6 0.54 8.8 23.6 1.2 1 0 0 1 1 1 0 Macoilin family PAP1 PF08601.10 EFA78136.1 - 0.95 9.1 27.5 1.4 8.6 27.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Glyco_transf_20 PF00982.21 EFA78137.1 - 2.5e-48 165.0 0.0 4e-48 164.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFA78137.1 - 1.9e-35 122.1 0.0 2.5e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Trehalose-phosphatase DUF1848 PF08902.11 EFA78137.1 - 0.079 12.7 0.1 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) DUF2183 PF09949.9 EFA78137.1 - 0.11 12.8 0.0 1.7 9.1 0.0 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2183) Glyco_transf_20 PF00982.21 EFA78138.1 - 1.5e-61 208.6 0.1 1.6e-61 208.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Baculo_p26 PF04766.12 EFA78138.1 - 0.0068 15.9 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus p26 protein DUF707 PF05212.12 EFA78138.1 - 0.015 14.5 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF707) Ank_2 PF12796.7 EFA78139.1 - 9.5e-28 96.6 3.1 2e-05 25.1 0.1 7.0 5 1 1 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78139.1 - 3.9e-20 71.9 8.2 0.02 15.5 0.0 9.2 7 2 1 8 8 8 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78139.1 - 8.9e-13 48.2 7.6 0.058 13.7 0.0 10.2 9 3 3 12 12 12 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78139.1 - 2.7e-10 39.6 1.2 3.5 8.5 0.0 10.2 12 1 1 13 13 13 1 Ankyrin repeat HLH PF00010.26 EFA78139.1 - 0.00034 20.5 0.5 0.002 18.1 0.4 2.4 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF249 PF03158.13 EFA78139.1 - 0.0016 18.2 6.5 0.1 12.3 0.1 4.3 3 1 2 5 5 5 1 Multigene family 530 protein DUF5049 PF16468.5 EFA78139.1 - 0.0023 17.8 1.3 9.9 6.2 0.0 5.7 6 2 1 7 7 7 1 Domain of unknown function (DUF5049) BTHB PF18410.1 EFA78139.1 - 0.037 13.8 0.6 0.33 10.8 0.6 2.7 1 1 0 1 1 1 0 Basic tilted helix bundle domain ZapB PF06005.12 EFA78139.1 - 2.5 8.6 6.2 0.21 12.1 1.2 1.7 2 0 0 2 2 2 0 Cell division protein ZapB TPR_1 PF00515.28 EFA78140.1 - 7.4e-14 50.9 2.0 6.7e-06 25.7 0.1 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78140.1 - 3.8e-10 39.1 4.6 0.0037 17.3 0.3 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78140.1 - 1.1e-07 31.5 0.2 0.011 15.5 0.0 3.3 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.6 EFA78140.1 - 1.9e-05 24.5 2.8 0.033 14.4 0.0 3.4 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78140.1 - 2.1e-05 24.7 3.3 0.013 15.8 1.4 4.0 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA78140.1 - 0.00055 20.1 0.2 0.15 12.5 0.0 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA78140.1 - 0.0006 20.4 0.0 3.7 8.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA78140.1 - 0.00096 19.6 7.7 0.53 11.0 0.1 4.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78140.1 - 0.001 19.7 0.0 3 8.9 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 EFA78140.1 - 0.0093 15.7 1.1 0.016 14.9 1.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_19 PF14559.6 EFA78140.1 - 0.011 16.2 4.4 0.75 10.4 0.4 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFA78140.1 - 0.028 13.8 0.2 7.3 6.1 0.0 3.1 3 0 0 3 3 3 0 SHNi-TPR MIT PF04212.18 EFA78140.1 - 0.28 11.3 9.3 0.67 10.1 0.4 4.3 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF3430 PF11912.8 EFA78141.1 - 6.5e-19 68.8 56.3 2e-11 44.3 20.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3430) Lactonase PF10282.9 EFA78142.1 - 2.2e-97 326.4 0.1 2.6e-97 326.2 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SGL PF08450.12 EFA78142.1 - 5.2e-05 23.0 0.6 3.8 7.0 0.0 4.2 2 2 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFA78142.1 - 0.002 18.3 0.2 8.2 6.7 0.0 4.1 4 0 0 4 4 4 2 Arylesterase EF1_GNE PF00736.19 EFA78143.1 - 6.5e-23 80.7 0.2 7.2e-23 80.6 0.2 1.0 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain Ank_2 PF12796.7 EFA78144.1 - 2.1e-05 25.0 1.6 0.0073 16.9 0.0 3.7 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) DUF249 PF03158.13 EFA78144.1 - 6.4e-05 22.7 2.4 0.27 10.9 0.2 2.8 2 0 0 2 2 2 2 Multigene family 530 protein Ank_4 PF13637.6 EFA78144.1 - 0.00023 21.6 0.2 0.63 10.7 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78144.1 - 0.0013 19.1 2.2 3.2 8.6 0.1 5.0 6 0 0 6 6 6 1 Ankyrin repeat Ank_5 PF13857.6 EFA78144.1 - 0.0034 17.6 0.2 2.6 8.5 0.0 4.2 3 1 1 4 4 4 1 Ankyrin repeats (many copies) T4SS_CagC PF16943.5 EFA78145.1 - 0.035 14.3 3.1 0.37 11.0 0.1 2.1 1 1 0 2 2 2 0 Cag pathogenicity island, type IV secretory system DUF1189 PF06691.11 EFA78145.1 - 0.096 12.2 13.2 0.011 15.3 9.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) DUF2417 PF10329.9 EFA78145.1 - 0.19 11.1 15.8 0.18 11.2 0.4 2.1 1 1 1 2 2 2 0 Region of unknown function (DUF2417) Tetraspanin PF00335.20 EFA78145.1 - 0.66 9.6 14.5 1.4 8.6 14.1 1.8 1 1 0 1 1 1 0 Tetraspanin family SUR7 PF06687.12 EFA78145.1 - 0.69 9.5 12.5 0.26 10.9 6.7 2.2 1 1 1 2 2 2 0 SUR7/PalI family MBOAT PF03062.19 EFA78146.1 - 6.3e-46 157.3 11.7 6.3e-46 157.3 11.7 2.1 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family BAR_3 PF16746.5 EFA78147.1 - 2.4e-71 240.2 18.4 5.7e-71 239.0 18.4 1.6 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 EFA78147.1 - 5.5e-36 123.2 0.1 5.5e-36 123.2 0.1 3.1 4 0 0 4 4 4 1 Putative GTPase activating protein for Arf PH PF00169.29 EFA78147.1 - 3e-11 43.8 0.1 3e-11 43.8 0.1 2.2 2 0 0 2 2 2 1 PH domain BAR PF03114.18 EFA78147.1 - 7e-09 35.7 9.1 1.7e-08 34.4 9.1 1.6 1 0 0 1 1 1 1 BAR domain FAM92 PF06730.11 EFA78147.1 - 0.004 16.6 4.5 0.0089 15.5 4.5 1.5 1 0 0 1 1 1 1 FAM92 protein DUF4449 PF14613.6 EFA78147.1 - 0.21 11.7 0.1 0.21 11.7 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4449) PH_11 PF15413.6 EFA78147.1 - 1.3 9.5 5.1 58 4.2 5.1 3.3 1 1 0 1 1 1 0 Pleckstrin homology domain Polysacc_synt_C PF14667.6 EFA78149.1 - 0.044 13.8 0.2 0.091 12.8 0.2 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain Podoplanin PF05808.11 EFA78149.1 - 0.16 12.1 0.6 0.39 10.8 0.6 1.6 1 0 0 1 1 1 0 Podoplanin EGF_Tenascin PF18720.1 EFA78149.1 - 1 9.5 10.8 2.1 8.5 10.8 1.5 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 EFA78149.1 - 1.5 9.3 9.5 2.5 8.5 9.5 1.4 1 0 0 1 1 1 0 EGF-like domain Mpv17_PMP22 PF04117.12 EFA78150.1 - 2.7e-22 78.7 0.9 5.5e-22 77.8 0.9 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family CAP PF00188.26 EFA78150.1 - 1.2e-09 39.0 0.1 2.5e-09 38.0 0.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ank_4 PF13637.6 EFA78151.1 - 2.7e-23 82.0 0.4 6.7e-10 39.3 0.1 4.7 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA78151.1 - 2.7e-22 79.1 0.5 2.5e-12 47.2 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78151.1 - 2e-21 75.8 0.1 5.4e-10 39.3 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA78151.1 - 5.3e-19 67.8 0.1 0.00026 21.3 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EFA78151.1 - 6.8e-19 66.0 0.2 0.00052 20.2 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat SAM_1 PF00536.30 EFA78151.1 - 1.9e-13 50.6 0.3 4e-13 49.6 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA78151.1 - 3.6e-10 39.8 0.3 9.3e-10 38.5 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3447 PF11929.8 EFA78151.1 - 0.03 14.3 0.9 3.4 7.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) Aldedh PF00171.22 EFA78153.1 - 5e-129 430.8 0.1 7.1e-129 430.3 0.1 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pkinase_Tyr PF07714.17 EFA78153.1 - 6.7e-52 176.3 0.0 1.3e-51 175.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA78153.1 - 2.1e-42 145.3 0.0 4.7e-42 144.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFA78154.1 - 4.9e-36 123.2 11.3 1.1e-06 29.1 0.1 7.9 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78154.1 - 4.8e-35 119.5 8.8 0.00021 21.8 0.0 10.8 5 3 5 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78154.1 - 2.6e-28 97.7 15.2 0.016 15.5 0.0 13.4 5 4 9 14 14 14 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78154.1 - 1.6e-20 71.0 6.7 5.5 7.9 0.0 14.3 12 2 3 15 15 15 4 Ankyrin repeat DUF5049 PF16468.5 EFA78154.1 - 0.0035 17.2 0.0 3.7 7.5 0.0 5.4 5 1 1 6 6 6 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA78154.1 - 0.0045 17.4 0.3 59 4.4 0.0 6.1 6 3 1 7 7 7 0 Ankyrin repeat PRD PF00874.20 EFA78154.1 - 0.0083 16.4 0.1 0.02 15.2 0.1 1.6 1 0 0 1 1 1 1 PRD domain DUF249 PF03158.13 EFA78154.1 - 0.42 10.3 12.3 1.7 8.3 0.1 4.6 3 2 2 6 6 6 0 Multigene family 530 protein Orf78 PF06024.12 EFA78155.1 - 0.0071 16.6 12.7 0.043 14.1 0.0 4.8 5 0 0 5 5 5 2 Orf78 (ac78) DUF919 PF06034.11 EFA78155.1 - 0.01 15.6 1.9 0.23 11.3 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF4441 PF14536.6 EFA78155.1 - 2 8.7 6.4 0.25 11.5 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) RCC1 PF00415.18 EFA78156.1 - 7e-65 215.5 14.7 2.5e-09 37.6 0.1 10.6 10 1 0 10 10 10 9 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA78156.1 - 1.4e-29 101.2 33.9 4.3e-08 32.7 0.0 9.0 9 0 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat Pim PF16765.5 EFA78157.1 - 0.07 13.3 0.0 0.074 13.2 0.0 1.1 1 0 0 1 1 1 0 Pesticin immunity protein SpmSyn_N PF17950.1 EFA78158.1 - 0.029 14.5 0.6 0.041 14.1 0.6 1.3 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase N -terminal Nup192 PF11894.8 EFA78159.1 - 6.1e-20 70.1 20.6 9.7e-13 46.3 7.2 2.7 2 1 0 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 TMEM220 PF15071.6 EFA78159.1 - 0.11 13.3 0.3 0.77 10.6 0.0 2.4 2 0 0 2 2 2 0 Transmembrane family 220, helix BTB_2 PF02214.22 EFA78160.1 - 0.047 14.0 1.1 5.5 7.4 0.9 3.0 3 0 0 3 3 3 0 BTB/POZ domain DNA_ligase_A_M PF01068.21 EFA78161.1 - 2.9e-50 170.8 0.9 1.5e-49 168.4 0.0 2.5 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFA78161.1 - 1.4e-29 103.6 1.9 1.4e-29 103.6 1.9 2.1 2 1 0 2 2 2 1 DNA ligase N terminus LIG3_BRCT PF16759.5 EFA78161.1 - 1.5e-16 60.4 0.0 3.3e-09 36.9 0.0 3.2 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 EFA78161.1 - 1.3e-15 57.6 1.3 3e-06 27.5 0.0 3.3 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 EFA78161.1 - 7.7e-15 55.3 0.0 2.3e-14 53.8 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EFA78161.1 - 2e-11 44.1 0.7 7.2e-05 23.1 0.0 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 EFA78161.1 - 8.5e-10 39.2 0.0 1.7e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 RNA ligase PTCB-BRCT PF12738.7 EFA78161.1 - 1.2e-05 25.2 0.0 0.15 12.0 0.0 2.8 2 0 0 2 2 2 2 twin BRCT domain mRNA_cap_enzyme PF01331.19 EFA78161.1 - 0.0086 15.9 0.0 0.075 12.8 0.0 2.3 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain AHJR-like PF18743.1 EFA78161.1 - 0.02 14.5 0.0 0.064 12.8 0.0 1.8 2 0 0 2 2 2 0 REase_AHJR-like TIG PF01833.24 EFA78162.1 - 1.6e-52 175.5 57.7 4e-11 42.8 5.0 13.5 10 2 2 12 12 12 10 IPT/TIG domain DNase_II PF03265.15 EFA78162.1 - 6.3e-28 98.0 14.9 6.9e-28 97.9 7.3 3.4 2 1 0 2 2 2 1 Deoxyribonuclease II His_Phos_1 PF00300.22 EFA78163.1 - 7e-35 120.5 0.0 1.4e-34 119.5 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pro_isomerase PF00160.21 EFA78163.1 - 1.2e-10 41.9 0.5 1.2e-10 41.9 0.5 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD AAR2 PF05282.11 EFA78163.1 - 1.2 8.4 15.2 0.35 10.2 9.8 2.2 2 0 0 2 2 2 0 AAR2 protein COX15-CtaA PF02628.15 EFA78165.1 - 1.2e-42 146.1 0.4 1.7e-42 145.7 0.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein RNF220 PF15926.5 EFA78165.1 - 0.00091 18.9 6.8 0.0012 18.5 6.8 1.1 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 SprA-related PF12118.8 EFA78165.1 - 0.079 12.1 18.3 0.1 11.7 18.3 1.1 1 0 0 1 1 1 0 SprA-related family Presenilin PF01080.17 EFA78165.1 - 1.1 8.0 6.5 1.4 7.6 6.5 1.2 1 0 0 1 1 1 0 Presenilin COX15-CtaA PF02628.15 EFA78166.1 - 2.2e-34 119.0 1.1 2.5e-34 118.8 1.1 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein TFIIS_M PF07500.14 EFA78167.1 - 2.4e-14 53.8 0.2 2.4e-14 53.8 0.2 4.3 5 0 0 5 5 5 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EFA78167.1 - 2.9e-07 30.3 9.9 8e-07 28.9 9.9 1.7 1 0 0 1 1 1 1 PHD-finger YL1_C PF08265.11 EFA78169.1 - 2.2e-12 46.5 1.5 4e-12 45.7 1.5 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain PBP1_TM PF14812.6 EFA78169.1 - 0.012 15.9 29.2 0.025 14.9 14.2 3.2 2 1 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-HIT PF04438.16 EFA78169.1 - 0.16 11.9 0.3 0.26 11.2 0.3 1.3 1 0 0 1 1 1 0 HIT zinc finger DUF3337 PF11816.8 EFA78170.1 - 3.5e-28 98.6 0.0 3.5e-28 98.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EFA78170.1 - 9.3e-28 95.9 20.9 2.6e-05 24.9 1.5 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78170.1 - 1.7e-05 25.0 0.9 0.98 9.8 0.1 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain RAWUL PF16207.5 EFA78170.1 - 0.37 11.5 2.1 0.44 11.3 0.1 2.2 2 0 0 2 2 2 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like TFIIA PF03153.13 EFA78170.1 - 2.4 8.1 32.8 0.035 14.1 18.9 2.7 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit MMR_HSR1 PF01926.23 EFA78171.1 - 6.2e-23 81.1 0.0 1.9e-22 79.5 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA78171.1 - 6.6e-10 39.1 0.1 0.0018 18.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EFA78171.1 - 1.2e-08 34.6 0.0 2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFA78171.1 - 8.7e-06 25.4 0.4 0.0013 18.3 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFA78171.1 - 0.00074 19.6 9.5 0.15 12.2 0.1 3.5 2 2 1 3 3 3 2 Dynamin family DDE_Tnp_ISAZ013 PF07592.11 EFA78171.1 - 0.0039 16.2 0.3 0.0039 16.2 0.3 2.0 2 1 0 2 2 2 1 Rhodopirellula transposase DDE domain AAA_29 PF13555.6 EFA78171.1 - 0.071 12.9 0.0 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Il2rg PF15874.5 EFA78171.1 - 0.16 12.2 1.3 0.41 10.9 0.1 2.3 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain ABC_tran PF00005.27 EFA78171.1 - 1.8 9.1 6.0 0.4 11.2 0.1 2.7 2 2 0 2 2 2 0 ABC transporter WD40 PF00400.32 EFA78172.1 - 2.9e-06 27.9 0.1 2.2 9.3 0.0 4.5 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78172.1 - 6.3e-06 26.4 0.6 0.35 11.2 0.0 3.7 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain UQ_con PF00179.26 EFA78174.1 - 7.2e-45 152.1 0.1 1e-44 151.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFA78174.1 - 0.0047 16.6 0.0 0.018 14.8 0.0 1.8 1 1 0 1 1 1 1 Prokaryotic E2 family B Ac76 PF05814.11 EFA78175.1 - 0.0019 18.2 0.7 0.041 13.9 0.1 2.0 2 0 0 2 2 2 1 Orf76 (Ac76) DUF973 PF06157.11 EFA78175.1 - 0.0026 16.9 0.7 0.0033 16.5 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF973) Holin_BhlA PF10960.8 EFA78175.1 - 0.0031 17.4 0.2 0.3 11.1 0.1 2.1 2 0 0 2 2 2 1 BhlA holin family 7TM_GPCR_Str PF10326.9 EFA78175.1 - 0.0032 16.9 2.4 0.43 9.9 0.3 2.0 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Str Shisa PF13908.6 EFA78175.1 - 0.0053 17.0 0.0 0.0062 16.8 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF2681 PF10883.8 EFA78175.1 - 0.006 17.0 0.3 0.014 15.8 0.3 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2681) DUF5305 PF17231.2 EFA78175.1 - 0.0072 15.7 0.1 0.0094 15.4 0.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Baculo_11_kDa PF06143.11 EFA78175.1 - 0.014 14.9 1.4 0.046 13.3 0.6 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family LapA_dom PF06305.11 EFA78175.1 - 0.014 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2304 PF10066.9 EFA78175.1 - 0.017 15.3 0.3 0.073 13.3 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) EphA2_TM PF14575.6 EFA78175.1 - 0.019 15.8 0.4 0.23 12.3 0.2 2.0 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4446 PF14584.6 EFA78175.1 - 0.025 14.6 0.5 0.1 12.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Acatn PF13000.7 EFA78175.1 - 0.034 12.7 0.1 0.034 12.6 0.1 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 YqzM PF14141.6 EFA78175.1 - 0.052 13.6 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 YqzM-like protein SLATT_6 PF18169.1 EFA78175.1 - 0.08 12.5 0.9 0.25 10.9 0.5 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 OAD_gamma PF04277.13 EFA78175.1 - 0.09 13.4 0.1 0.14 12.8 0.1 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain 7TM_GPCR_Srj PF10319.9 EFA78175.1 - 0.099 12.0 0.6 2.8 7.2 0.1 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srj PspB PF06667.12 EFA78175.1 - 0.48 10.5 2.3 1.2 9.2 2.3 1.7 1 1 0 1 1 1 0 Phage shock protein B DUF5325 PF17259.2 EFA78175.1 - 3.8 7.5 9.8 0.4 10.6 5.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5325) NDK PF00334.19 EFA78176.1 - 3.8e-53 179.1 0.0 4.2e-53 179.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase RhoGEF PF00621.20 EFA78177.1 - 3.5e-36 125.1 10.4 3.5e-36 125.1 10.4 2.0 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EFA78177.1 - 0.056 13.9 1.3 0.15 12.6 0.3 2.3 2 0 0 2 2 2 0 PH domain RabGAP-TBC PF00566.18 EFA78179.1 - 4.9e-42 144.0 8.0 4.9e-42 144.0 8.0 4.4 4 0 0 4 4 4 1 Rab-GTPase-TBC domain EF-hand_1 PF00036.32 EFA78179.1 - 0.0015 17.9 3.8 0.0017 17.8 0.6 2.8 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EFA78179.1 - 0.0083 16.6 4.3 0.017 15.5 1.9 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA78179.1 - 0.12 12.4 0.2 0.12 12.4 0.2 4.8 4 1 1 5 5 5 0 EF-hand domain PRK PF00485.18 EFA78181.1 - 1.7e-48 165.0 0.1 2.7e-48 164.3 0.1 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EFA78181.1 - 1.7e-07 31.9 0.5 7.7e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 EFA78181.1 - 0.00025 20.8 0.0 0.092 12.5 0.0 2.6 1 1 1 2 2 2 1 Cytidylate kinase Zeta_toxin PF06414.12 EFA78181.1 - 0.00027 20.3 0.0 0.00074 18.9 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin T2SSE PF00437.20 EFA78181.1 - 0.00059 19.0 0.0 0.00096 18.3 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein CoaE PF01121.20 EFA78181.1 - 0.002 17.8 0.3 0.19 11.4 0.0 2.7 3 0 0 3 3 3 1 Dephospho-CoA kinase MAGE_N PF12440.8 EFA78181.1 - 0.0044 17.7 5.1 0.28 11.9 1.4 2.3 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal SRP54 PF00448.22 EFA78181.1 - 0.0044 16.7 0.0 0.0095 15.6 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Cytidylate_kin2 PF13189.6 EFA78181.1 - 0.0062 16.7 0.2 0.015 15.4 0.1 1.8 1 1 0 1 1 1 1 Cytidylate kinase-like family MobB PF03205.14 EFA78181.1 - 0.011 15.6 0.1 0.045 13.6 0.1 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 EFA78181.1 - 0.015 15.2 0.2 0.11 12.4 0.0 2.4 3 0 0 3 3 3 0 Adenylylsulphate kinase ATP_bind_1 PF03029.17 EFA78181.1 - 0.015 15.1 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Tubulin PF00091.25 EFA78181.1 - 0.016 15.4 0.3 0.038 14.2 0.0 1.8 2 0 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain cobW PF02492.19 EFA78181.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EFA78181.1 - 0.017 15.1 0.3 0.064 13.2 0.0 2.0 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TrwB_AAD_bind PF10412.9 EFA78181.1 - 0.021 13.8 0.0 0.033 13.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.6 EFA78181.1 - 0.023 14.4 0.0 0.043 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain SR-25 PF10500.9 EFA78181.1 - 0.03 13.9 11.5 0.046 13.3 11.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_17 PF13207.6 EFA78181.1 - 0.03 14.7 4.8 0.033 14.6 0.7 2.8 2 1 0 2 2 1 0 AAA domain AAA_22 PF13401.6 EFA78181.1 - 0.051 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EFA78181.1 - 0.064 12.9 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_14 PF13173.6 EFA78181.1 - 0.065 13.3 0.0 0.28 11.2 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA78181.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Thymidylate_kin PF02223.17 EFA78181.1 - 0.15 11.8 1.1 1.2 8.8 0.0 2.5 3 0 0 3 3 2 0 Thymidylate kinase AAA_28 PF13521.6 EFA78181.1 - 0.16 12.2 0.1 0.58 10.4 0.1 2.0 1 1 1 2 2 2 0 AAA domain Ndc1_Nup PF09531.10 EFA78181.1 - 0.45 9.2 3.2 0.52 8.9 3.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ResIII PF04851.15 EFA78181.1 - 2.2 8.2 6.5 0.41 10.6 1.0 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit STAC2_u1 PF16664.5 EFA78181.1 - 2.7 8.4 9.1 5.6 7.4 9.1 1.5 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Acetyltransf_9 PF13527.7 EFA78182.1 - 2e-11 44.1 0.0 2.9e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA78182.1 - 1.2e-08 35.2 0.0 1.9e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA78182.1 - 1.8e-06 28.3 0.0 3.5e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA78182.1 - 4e-05 23.6 0.0 7.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFA78182.1 - 0.00034 20.7 0.0 0.00062 19.8 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFA78182.1 - 0.035 14.1 0.2 1.6 8.7 0.1 2.3 1 1 1 2 2 2 0 FR47-like protein DNase_II PF03265.15 EFA78183.1 - 5.5e-23 81.8 12.0 2.7e-14 53.2 0.3 3.0 3 0 0 3 3 3 3 Deoxyribonuclease II MoCF_biosynth PF00994.24 EFA78185.1 - 1.8e-57 193.0 3.6 9e-29 100.0 0.2 2.9 3 0 0 3 3 3 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EFA78185.1 - 7.8e-41 139.5 1.9 1.2e-40 138.8 1.9 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EFA78185.1 - 2.9e-10 40.2 0.0 6.8e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) WSC PF01822.19 EFA78186.1 - 2.1e-25 88.7 41.6 2.7e-16 59.5 9.8 3.2 4 0 0 4 4 4 2 WSC domain CAP PF00188.26 EFA78186.1 - 1.3e-15 58.3 4.0 1.8e-15 57.9 0.2 2.5 2 0 0 2 2 2 1 Cysteine-rich secretory protein family DUF4422 PF14393.6 EFA78187.1 - 0.021 14.7 0.0 0.072 12.9 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) Sec7 PF01369.20 EFA78188.1 - 9.2e-34 116.7 3.0 3.6e-33 114.8 3.0 2.0 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EFA78188.1 - 2.5e-21 76.2 5.0 2.5e-21 76.2 5.0 3.3 3 1 1 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Roughex PF06020.11 EFA78188.1 - 6.9 5.7 11.8 18 4.3 11.8 1.6 1 0 0 1 1 1 0 Drosophila roughex protein G0-G1_switch_2 PF15103.6 EFA78188.1 - 9.6 6.7 7.4 1.1 9.8 1.8 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF4327 PF14217.6 EFA78189.1 - 0.043 14.0 0.1 0.14 12.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4327) ADK PF00406.22 EFA78190.1 - 2.8e-49 167.1 0.0 3.3e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFA78190.1 - 1.2e-35 122.9 0.0 1.6e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFA78190.1 - 1.1e-07 32.5 0.0 1.6e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFA78190.1 - 1.6e-06 28.4 0.0 3.2e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EFA78190.1 - 2.2e-05 24.2 0.1 0.16 11.7 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 EFA78190.1 - 0.0003 20.1 0.1 0.0012 18.2 0.1 1.8 1 1 0 1 1 1 1 Zeta toxin FlaG PF03646.15 EFA78190.1 - 0.0084 16.3 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 FlaG protein Ploopntkinase3 PF18751.1 EFA78190.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_19 PF13245.6 EFA78190.1 - 0.17 12.2 0.3 0.22 11.9 0.3 1.6 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 EFA78191.1 - 2.3e-28 99.3 0.2 2.1e-23 83.1 0.1 2.5 1 1 1 2 2 2 2 Protein kinase domain PH_3 PF14593.6 EFA78191.1 - 5.4e-28 97.1 0.8 1e-27 96.2 0.1 1.8 2 0 0 2 2 2 1 PH domain Pkinase_Tyr PF07714.17 EFA78191.1 - 1.6e-13 50.6 0.1 1.6e-11 44.0 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase AP1AR PF15745.5 EFA78191.1 - 2 8.0 11.5 9.9 5.7 9.2 2.2 2 0 0 2 2 2 0 AP-1 complex-associated regulatory protein Macoilin PF09726.9 EFA78191.1 - 2 6.8 13.9 0.012 14.2 5.4 1.5 2 0 0 2 2 2 0 Macoilin family bZIP_1 PF00170.21 EFA78192.1 - 1.2e-09 38.2 9.4 2.3e-09 37.2 5.6 2.4 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFA78192.1 - 6.8e-05 22.9 5.3 6.8e-05 22.9 5.3 2.2 2 0 0 2 2 2 1 Basic region leucine zipper SesA PF17107.5 EFA78192.1 - 0.063 13.5 2.6 0.11 12.7 0.9 2.0 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases bZIP_Maf PF03131.17 EFA78192.1 - 2 9.0 12.3 0.15 12.6 6.7 2.0 2 0 0 2 2 2 0 bZIP Maf transcription factor RCC1 PF00415.18 EFA78194.1 - 5.9e-37 126.1 10.0 3.8e-07 30.6 0.0 7.9 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA78194.1 - 1.2e-23 82.3 30.2 1.3e-08 34.4 0.1 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat ADH_N PF08240.12 EFA78194.1 - 0.015 15.1 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain PapC_C PF13953.6 EFA78194.1 - 0.15 11.9 2.0 14 5.6 0.2 3.2 3 0 0 3 3 3 0 PapC C-terminal domain Peptidase_S49 PF01343.18 EFA78195.1 - 0.035 14.0 0.1 0.039 13.9 0.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 fn3 PF00041.21 EFA78196.1 - 5e-17 62.0 16.5 0.00029 21.1 1.9 6.6 6 1 1 7 7 7 4 Fibronectin type III domain DUF2369 PF10179.9 EFA78196.1 - 1.1e-06 29.0 16.2 0.016 15.6 0.7 5.1 5 0 0 5 5 5 3 Uncharacterised conserved protein (DUF2369) SusE PF14292.6 EFA78196.1 - 0.0011 19.1 1.4 0.0011 19.1 1.4 6.0 6 1 1 7 7 7 1 SusE outer membrane protein HisG_C PF08029.11 EFA78196.1 - 0.045 13.9 0.2 0.91 9.7 0.1 2.6 2 0 0 2 2 2 0 HisG, C-terminal domain Chitin_synth_1 PF01644.17 EFA78196.1 - 0.092 12.7 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Chitin synthase Pkinase PF00069.25 EFA78197.1 - 6.4e-07 29.0 0.0 6.4e-07 29.0 0.0 3.6 4 0 0 4 4 4 1 Protein kinase domain OEP PF02321.18 EFA78198.1 - 0.014 15.3 6.7 0.021 14.6 6.7 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein DUF737 PF05300.11 EFA78198.1 - 0.014 15.7 12.0 0.023 15.1 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Jnk-SapK_ap_N PF09744.9 EFA78198.1 - 0.063 13.5 11.6 0.12 12.6 11.6 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 CRAL_TRIO PF00650.20 EFA78199.1 - 9e-26 90.5 1.2 1.7e-25 89.6 1.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFA78199.1 - 6.5e-05 23.1 0.1 0.00013 22.1 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain COesterase PF00135.28 EFA78200.1 - 8e-13 48.1 0.2 1.3e-12 47.3 0.2 1.4 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA78200.1 - 1.3e-10 41.5 0.0 1e-09 38.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 EFA78200.1 - 0.00046 19.9 0.1 0.0007 19.3 0.1 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Chlorophyllase PF07224.11 EFA78200.1 - 0.0021 17.1 0.0 0.0034 16.5 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase Chlorophyllase2 PF12740.7 EFA78200.1 - 0.0022 17.0 0.0 0.0033 16.4 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 EFA78200.1 - 0.0024 17.5 1.5 0.024 14.3 0.6 2.3 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA78200.1 - 0.008 15.5 0.0 0.15 11.3 0.0 2.5 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EFA78200.1 - 0.066 13.0 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase LCAT PF02450.15 EFA78200.1 - 0.08 12.1 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase PE-PPE PF08237.11 EFA78200.1 - 0.17 11.4 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain OPT PF03169.15 EFA78201.1 - 3.9e-134 448.6 31.9 4.6e-134 448.4 31.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CAAD PF14159.6 EFA78201.1 - 0.054 13.3 2.0 1 9.3 0.0 3.5 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase PsaM PF07465.13 EFA78201.1 - 0.19 11.5 4.3 0.11 12.2 0.7 2.4 2 0 0 2 2 2 0 Photosystem I protein M (PsaM) Ank_2 PF12796.7 EFA78202.1 - 7.4e-39 132.2 13.5 9.7e-09 35.7 0.0 7.9 3 3 5 8 8 8 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78202.1 - 7.9e-32 108.9 15.9 3.1e-05 24.2 0.4 14.5 6 3 10 16 16 16 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA78202.1 - 2.1e-29 101.5 15.5 0.00052 20.5 0.1 11.2 5 4 5 11 11 11 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78202.1 - 1.2e-23 80.6 13.5 1.2 9.9 0.0 15.5 15 2 2 17 17 17 4 Ankyrin repeat Ank PF00023.30 EFA78202.1 - 7e-07 29.4 3.0 87 3.8 0.0 9.1 7 2 1 8 8 8 0 Ankyrin repeat DUF249 PF03158.13 EFA78202.1 - 3.8e-05 23.5 12.4 0.055 13.2 0.5 5.9 3 2 2 5 5 5 2 Multigene family 530 protein DUF3447 PF11929.8 EFA78202.1 - 0.00061 19.7 13.0 0.0084 16.0 0.9 6.2 6 3 1 7 7 7 1 Domain of unknown function (DUF3447) FBD PF08387.10 EFA78202.1 - 0.047 13.6 5.4 9.7 6.2 0.0 5.6 7 0 0 7 7 7 0 FBD Kunitz_BPTI PF00014.23 EFA78202.1 - 0.11 12.8 0.4 5.2 7.4 0.1 2.9 1 1 1 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain ketoacyl-synt PF00109.26 EFA78203.1 - 1e-65 221.8 0.0 1.8e-65 221.1 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA78203.1 - 4.8e-55 187.3 0.0 8.3e-55 186.5 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA78203.1 - 9.5e-35 119.2 0.1 1.8e-34 118.2 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA78203.1 - 3.5e-33 115.0 0.0 8.1e-33 113.8 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EFA78203.1 - 2.2e-18 66.5 0.0 2.3e-11 43.5 0.0 2.3 2 0 0 2 2 2 2 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA78203.1 - 4.1e-15 56.2 0.0 1.1e-14 54.9 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFA78203.1 - 1e-10 41.4 0.0 1.2e-08 34.7 0.0 2.7 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EFA78203.1 - 3.8e-10 40.9 0.0 1.8e-09 38.7 0.0 2.2 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 EFA78203.1 - 5.1e-09 36.8 0.0 2.1e-08 34.8 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EFA78203.1 - 2.1e-08 34.2 0.0 1.8e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFA78203.1 - 5.6e-07 29.4 0.0 1.7e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_25 PF13649.6 EFA78203.1 - 0.00011 22.9 0.0 0.00097 19.8 0.0 2.7 3 0 0 3 3 2 1 Methyltransferase domain ADH_N PF08240.12 EFA78203.1 - 0.00066 19.5 0.1 0.0015 18.4 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EFA78203.1 - 0.0031 16.9 0.0 0.0066 15.8 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 EFA78203.1 - 0.0092 16.6 0.0 0.038 14.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA78203.1 - 0.018 14.8 0.0 0.063 13.1 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PP-binding PF00550.25 EFA78203.1 - 0.028 14.8 0.0 0.1 13.0 0.0 2.0 1 0 0 1 1 1 0 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 EFA78203.1 - 0.086 12.6 0.0 0.25 11.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain ACP_syn_III PF08545.10 EFA78203.1 - 0.2 11.5 0.3 0.69 9.8 0.3 1.9 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III TIG PF01833.24 EFA78204.1 - 1.8e-226 733.0 854.8 3.1e-12 46.4 1.5 61.5 58 6 1 59 59 59 49 IPT/TIG domain Qn_am_d_aIII PF09099.10 EFA78204.1 - 2.8e-05 24.4 79.4 0.9 10.0 0.0 23.1 28 0 0 28 28 28 5 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Arg_tRNA_synt_N PF03485.16 EFA78204.1 - 0.041 14.5 1.6 1.7e+02 2.9 0.0 5.8 6 0 0 6 6 6 0 Arginyl tRNA synthetase N terminal domain RhoGAP PF00620.27 EFA78205.1 - 3.2e-35 121.2 0.0 1.3e-34 119.3 0.0 2.1 1 0 0 1 1 1 1 RhoGAP domain zf-MYND PF01753.18 EFA78205.1 - 5e-09 36.1 10.9 9.1e-09 35.3 10.9 1.4 1 0 0 1 1 1 1 MYND finger DUF4726 PF15855.5 EFA78205.1 - 0.13 12.5 0.1 0.13 12.5 0.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4726) DUF3439 PF11921.8 EFA78205.1 - 1.7 8.6 11.8 8.7 6.3 11.8 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TIG PF01833.24 EFA78206.1 - 4.2e-106 347.2 782.9 2.7e-12 46.6 5.9 49.2 33 2 6 40 40 40 31 IPT/TIG domain Qn_am_d_aIII PF09099.10 EFA78206.1 - 0.00021 21.6 31.8 1 9.8 0.1 13.0 14 0 0 14 14 14 3 Quinohemoprotein amine dehydrogenase, alpha subunit domain III TPR_1 PF00515.28 EFA78207.1 - 7.1e-23 79.4 9.1 0.00017 21.3 0.3 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78207.1 - 1e-19 68.9 6.9 0.0013 18.7 0.5 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78207.1 - 3.9e-11 42.2 6.8 0.067 13.4 0.0 5.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78207.1 - 7.1e-08 32.6 0.3 0.029 15.2 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA78207.1 - 1.3e-07 32.1 0.3 0.34 11.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78207.1 - 1.3e-06 28.6 6.1 0.0013 19.0 0.2 4.2 4 2 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78207.1 - 7.4e-05 22.4 11.9 0.7 9.6 0.1 4.2 4 1 0 4 4 4 3 TPR repeat TPR_15 PF13429.6 EFA78207.1 - 0.002 17.4 0.0 1.4 8.1 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA78207.1 - 0.0052 17.3 2.0 4.5 7.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFA78207.1 - 0.0076 16.4 0.4 9.9 6.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA78207.1 - 0.0083 16.2 7.4 1.8 8.7 0.1 4.4 5 0 0 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 EFA78207.1 - 0.032 14.3 3.8 5.1 7.3 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Macoilin PF09726.9 EFA78207.1 - 0.55 8.7 39.0 0.039 12.5 7.6 2.2 2 0 0 2 2 2 0 Macoilin family SHNi-TPR PF10516.9 EFA78207.1 - 0.59 9.6 12.6 0.55 9.7 0.1 4.7 6 0 0 6 6 6 0 SHNi-TPR TPR_10 PF13374.6 EFA78207.1 - 1.9 8.4 7.8 9.6 6.2 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA78207.1 - 4 8.3 8.2 32 5.5 0.5 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat SPX PF03105.19 EFA78207.1 - 9.7 6.0 32.0 0.31 10.9 5.8 2.2 2 0 0 2 2 2 0 SPX domain PseudoU_synth_2 PF00849.22 EFA78208.1 - 6.6e-29 101.1 6.8 1.3e-13 51.4 0.0 3.6 4 0 0 4 4 4 2 RNA pseudouridylate synthase RRM_1 PF00076.22 EFA78209.1 - 4.9e-29 99.9 0.0 4.9e-15 55.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA78209.1 - 0.00059 19.4 0.0 0.67 9.6 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA78209.1 - 0.061 13.4 0.0 0.17 12.0 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif OB_RNB PF08206.11 EFA78209.1 - 0.093 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain zf-CDGSH PF09360.10 EFA78210.1 - 6.7e-19 67.8 2.1 1.2e-09 38.2 0.2 2.3 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type zf-CSL PF05207.13 EFA78210.1 - 0.0066 16.2 1.2 0.25 11.1 0.0 2.2 2 0 0 2 2 2 2 CSL zinc finger PH PF00169.29 EFA78211.1 - 5.4e-24 84.7 3.8 1.1e-11 45.1 0.2 2.5 2 0 0 2 2 2 2 PH domain Yop-YscD_cpl PF16697.5 EFA78211.1 - 1.3e-16 60.7 0.1 2.9e-16 59.6 0.1 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 EFA78211.1 - 2.2e-16 59.9 1.3 6.2e-16 58.5 1.3 1.8 1 0 0 1 1 1 1 FHA domain PH_11 PF15413.6 EFA78211.1 - 8.8e-09 35.7 7.3 0.002 18.5 1.8 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EFA78211.1 - 2.7e-05 24.4 3.0 0.16 12.3 1.9 3.2 2 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 EFA78211.1 - 0.00021 21.7 1.5 2.9 8.3 0.1 4.0 2 2 1 3 3 3 2 Pleckstrin homology domain TIG PF01833.24 EFA78212.1 - 1.2e-18 67.0 59.0 2.4e-07 30.7 2.2 7.4 5 2 2 7 7 7 5 IPT/TIG domain ANAPC10 PF03256.16 EFA78212.1 - 0.048 13.3 0.1 0.34 10.5 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, subunit 10 (APC10) Brix PF04427.18 EFA78214.1 - 1.8e-36 126.1 0.2 1.8e-36 126.1 0.2 1.5 2 0 0 2 2 2 1 Brix domain Cpn10 PF00166.21 EFA78215.1 - 5.3e-11 42.4 0.0 6.2e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit DUF2012 PF09430.10 EFA78216.1 - 7.2e-21 74.6 0.1 1.3e-20 73.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 EFA78216.1 - 0.0034 17.4 0.1 0.0065 16.5 0.1 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain CarboxypepD_reg PF13620.6 EFA78216.1 - 0.012 15.8 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain PepSY_TM PF03929.16 EFA78216.1 - 0.08 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region PIRT PF15099.6 EFA78216.1 - 0.087 12.4 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Y_Y_Y PF07495.13 EFA78216.1 - 0.095 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Y_Y_Y domain SdrD_B PF17210.3 EFA78216.1 - 0.14 12.4 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 SdrD B-like domain EMP24_GP25L PF01105.24 EFA78216.1 - 0.25 11.3 2.5 0.26 11.2 0.2 2.0 2 1 1 3 3 3 0 emp24/gp25L/p24 family/GOLD LSM PF01423.22 EFA78217.1 - 1.6e-14 53.3 0.4 2e-14 53.0 0.4 1.2 1 0 0 1 1 1 1 LSM domain JAB PF01398.21 EFA78218.1 - 3.5e-09 36.6 0.0 8.7e-09 35.4 0.0 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MKT1_C PF12246.8 EFA78219.1 - 9.8e-46 155.9 0.4 9.8e-46 155.9 0.4 2.7 4 1 0 4 4 4 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EFA78219.1 - 1.2e-23 83.3 0.0 3.2e-23 81.9 0.0 1.8 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.18 EFA78219.1 - 1.8e-05 25.0 0.0 5e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EFA78219.1 - 6e-05 23.4 0.0 0.0065 16.9 0.0 2.9 2 0 0 2 2 2 1 XPG N-terminal domain Pox_A12 PF04651.13 EFA78219.1 - 0.058 13.5 3.8 0.12 12.4 3.8 1.4 1 0 0 1 1 1 0 Poxvirus A12 protein SSP160 PF06933.11 EFA78219.1 - 0.56 8.4 16.6 0.85 7.7 16.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 EFA78219.1 - 0.96 7.5 8.3 1.4 6.9 8.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Sporozoite_P67 PF05642.11 EFA78219.1 - 4.3 5.3 10.1 6.5 4.7 10.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TMEM154 PF15102.6 EFA78219.1 - 7.7 6.4 7.9 34 4.3 8.4 1.8 2 0 0 2 2 2 0 TMEM154 protein family GMC_oxred_N PF00732.19 EFA78221.1 - 6.1e-44 150.6 0.0 2.5e-43 148.5 0.0 1.8 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA78221.1 - 3e-26 92.6 0.1 5e-26 91.9 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase ApbA PF02558.16 EFA78221.1 - 0.00021 20.9 0.0 0.00038 20.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 EFA78221.1 - 0.00079 18.2 0.0 0.0021 16.8 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EFA78221.1 - 0.0034 17.6 0.4 0.008 16.4 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFA78221.1 - 0.01 14.9 0.7 0.019 14.1 0.7 1.4 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EFA78221.1 - 0.012 14.7 0.1 0.018 14.1 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EFA78221.1 - 0.016 14.5 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA78221.1 - 0.027 14.1 0.1 0.041 13.5 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFA78221.1 - 0.043 13.1 0.0 0.11 11.8 0.2 1.5 2 0 0 2 2 2 0 FAD binding domain TrkA_N PF02254.18 EFA78221.1 - 0.061 13.6 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain GIDA PF01134.22 EFA78221.1 - 0.12 11.4 0.3 0.18 10.9 0.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A MARVEL PF01284.23 EFA78222.1 - 0.0038 17.3 8.8 0.01 15.9 8.8 1.8 1 1 0 1 1 1 1 Membrane-associating domain Epiglycanin_C PF14654.6 EFA78222.1 - 0.061 13.4 0.9 0.17 12.0 0.8 1.9 1 1 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region DUF3384 PF11864.8 EFA78223.1 - 4.1e-18 65.5 0.0 2.9e-14 52.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3384) Mucin PF01456.17 EFA78223.1 - 0.01 15.8 30.8 0.022 14.7 18.1 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein VasL PF12486.8 EFA78223.1 - 0.095 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Type VI secretion system, EvfB, or VasL Neugrin PF06413.11 EFA78223.1 - 0.14 12.1 0.3 0.26 11.3 0.2 1.4 1 1 0 1 1 1 0 Neugrin DUF3439 PF11921.8 EFA78223.1 - 0.18 11.8 23.0 0.058 13.4 11.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) MGC-24 PF05283.11 EFA78223.1 - 7.5 7.0 13.3 3.2 8.2 6.3 2.4 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Rap_GAP PF02145.15 EFA78224.1 - 5.1e-56 189.2 0.8 1.3e-55 187.8 0.8 1.8 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EFA78224.1 - 1.5e-25 90.1 10.2 1.5e-25 90.1 10.2 2.9 3 0 0 3 3 3 1 Tuberin EF-hand_3 PF09069.11 EFA78224.1 - 0.034 14.6 0.3 0.098 13.1 0.3 1.8 1 0 0 1 1 1 0 EF-hand Ank_2 PF12796.7 EFA78225.1 - 8.3e-11 42.3 0.0 0.0079 16.8 0.0 3.4 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78225.1 - 1.6e-08 34.9 0.4 0.036 14.7 0.0 4.6 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78225.1 - 2.4e-06 27.7 0.1 26 5.3 0.0 5.8 3 2 3 6 6 6 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78225.1 - 3.4e-06 27.0 0.0 68 4.5 0.0 6.5 7 0 0 7 7 7 0 Ankyrin repeat Aminotran_1_2 PF00155.21 EFA78226.1 - 5.7e-51 173.8 0.0 7.6e-51 173.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFA78226.1 - 0.00018 20.1 0.0 0.00028 19.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Ank_2 PF12796.7 EFA78227.1 - 4.8e-12 46.3 3.7 8.1e-06 26.3 0.0 5.3 5 1 0 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78227.1 - 0.0014 19.1 1.5 1.7 9.3 0.0 5.5 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Adeno_knob PF00541.17 EFA78227.1 - 0.12 12.1 0.3 0.25 11.1 0.3 1.5 1 0 0 1 1 1 0 Adenoviral fibre protein (knob domain) Ank_3 PF13606.6 EFA78227.1 - 1.6 9.6 6.3 99 4.0 0.0 6.2 8 0 0 8 8 8 0 Ankyrin repeat MIT PF04212.18 EFA78228.1 - 5.1e-24 84.1 10.7 3.6e-12 46.2 2.1 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain LIM PF00412.22 EFA78228.1 - 8.1e-08 32.4 1.2 3e-06 27.4 1.3 2.3 1 1 0 1 1 1 1 LIM domain Arrestin_C PF02752.22 EFA78228.1 - 7e-07 29.8 0.9 1.5e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain MG2 PF01835.19 EFA78228.1 - 0.0001 22.7 0.0 0.00034 21.0 0.0 1.9 1 0 0 1 1 1 1 MG2 domain TPR_2 PF07719.17 EFA78228.1 - 0.13 12.4 3.7 1.1 9.5 0.6 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78228.1 - 0.87 10.0 5.0 7.1 7.1 0.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA78228.1 - 1.1 9.2 4.1 6.2 6.8 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Dicty_spore_N PF04562.12 EFA78229.1 - 2.3e-14 54.0 27.8 2.3e-14 54.0 27.8 4.4 4 1 1 5 5 5 2 Dictyostelium spore coat protein, N terminus UFC1 PF08694.11 EFA78232.1 - 1.1e-85 284.9 0.3 1.3e-85 284.7 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 EFA78232.1 - 0.0086 16.4 0.0 0.01 16.1 0.0 1.3 1 0 0 1 1 1 1 RWD domain UQ_con PF00179.26 EFA78232.1 - 0.011 15.4 0.4 0.031 13.9 0.4 1.8 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme Myosin_head PF00063.21 EFA78234.1 - 1.3e-271 902.8 0.1 1.7e-271 902.3 0.1 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFA78234.1 - 3e-45 154.2 4.2 6.7e-45 153.1 4.2 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EFA78234.1 - 6.6e-19 67.3 1.0 1.3e-18 66.3 1.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA78234.1 - 7.1e-19 67.4 0.1 1.8e-18 66.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA78234.1 - 3.6e-15 55.4 0.1 8e-15 54.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain IQ PF00612.27 EFA78234.1 - 0.0038 16.9 0.1 0.012 15.3 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_16 PF13191.6 EFA78234.1 - 0.0081 16.6 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFA78234.1 - 0.03 14.6 0.0 0.15 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFA78234.1 - 0.036 13.3 0.0 0.083 12.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 EFA78234.1 - 0.037 13.9 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 EFA78234.1 - 0.061 13.8 0.8 0.18 12.3 0.0 2.3 2 1 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EFA78234.1 - 0.074 12.7 0.2 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain TrwB_AAD_bind PF10412.9 EFA78234.1 - 0.099 11.5 0.4 0.66 8.8 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 EFA78234.1 - 0.49 10.8 1.8 1.3 9.4 0.1 2.6 3 0 0 3 3 2 0 RNA helicase Glycos_transf_4 PF00953.21 EFA78236.1 - 7.4e-35 120.3 13.1 7.4e-35 120.3 13.1 2.1 3 1 0 3 3 3 1 Glycosyl transferase family 4 DUF202 PF02656.15 EFA78236.1 - 1.7 9.2 6.3 1.1 9.7 0.4 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) BTB_2 PF02214.22 EFA78237.1 - 2.9e-18 66.0 0.2 5.9e-18 65.0 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EFA78237.1 - 0.0055 16.8 0.9 0.014 15.5 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain BTB PF00651.31 EFA78237.1 - 0.0075 16.5 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain adh_short PF00106.25 EFA78238.1 - 5e-35 120.7 0.0 6.7e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA78238.1 - 3.8e-28 98.6 0.0 4.9e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA78238.1 - 1.2e-05 25.3 0.0 1.7e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 KR domain NDT80_PhoG PF05224.12 EFA78241.1 - 2e-22 80.3 0.3 2e-22 80.3 0.3 5.7 3 2 0 3 3 3 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.6 EFA78241.1 - 2.6e-09 36.1 0.1 6.8e-09 34.7 0.1 1.7 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.6 EFA78241.1 - 3e-09 37.0 0.0 6.3e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Chaperone of endosialidase ETRAMP PF09716.10 EFA78241.1 - 0.0047 17.0 0.0 0.0047 17.0 0.0 2.8 2 2 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) DUF2207 PF09972.9 EFA78241.1 - 0.053 12.3 0.1 0.053 12.3 0.1 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4337 PF14235.6 EFA78241.1 - 0.17 12.0 0.0 0.17 12.0 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4337) DUF4834 PF16118.5 EFA78241.1 - 1.2 10.2 0.0 1.2 10.2 0.0 5.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) ABC_tran PF00005.27 EFA78242.1 - 1.4e-05 25.7 0.0 1.5e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 ABC transporter Fibrillin_U_N PF18193.1 EFA78242.1 - 0.11 12.7 0.2 23 5.2 0.0 2.4 2 0 0 2 2 2 0 Fibrillin 1 unique N-terminal domain Formyl_trans_N PF00551.19 EFA78244.1 - 4.4e-48 163.4 0.1 5.1e-48 163.2 0.1 1.0 1 0 0 1 1 1 1 Formyl transferase PALP PF00291.25 EFA78244.1 - 0.044 13.2 0.0 0.064 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme THDPS_N_2 PF14805.6 EFA78244.1 - 0.064 13.5 0.1 0.35 11.1 0.1 2.1 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal DnaJ PF00226.31 EFA78245.1 - 3.4e-20 71.9 3.8 4.6e-20 71.5 1.5 2.7 2 0 0 2 2 2 1 DnaJ domain UBN_AB PF14075.6 EFA78245.1 - 5.1e-08 32.9 2.0 5.1e-08 32.9 2.0 7.2 4 2 1 5 5 5 1 Ubinuclein conserved middle domain HUN PF08729.10 EFA78245.1 - 2.7e-07 30.5 8.2 2.7e-07 30.5 8.2 2.7 2 0 0 2 2 2 1 HPC2 and ubinuclein domain HTH_40 PF14493.6 EFA78245.1 - 0.0096 16.4 0.3 0.0096 16.4 0.3 3.2 2 1 0 2 2 2 1 Helix-turn-helix domain Cpn60_TCP1 PF00118.24 EFA78246.1 - 1.6e-163 544.9 0.1 1.8e-163 544.7 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Erf4 PF10256.9 EFA78247.1 - 5.1e-06 26.6 0.0 2.5e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family SUIM_assoc PF16619.5 EFA78247.1 - 0.019 15.0 7.0 0.052 13.6 7.0 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Claudin_2 PF13903.6 EFA78247.1 - 0.079 12.7 0.6 0.12 12.1 0.0 1.6 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF3040 PF11239.8 EFA78247.1 - 0.084 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF2157 PF09925.9 EFA78247.1 - 0.16 11.8 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) UPF0262 PF06793.12 EFA78248.1 - 0.036 14.2 1.4 0.057 13.5 1.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) Med3 PF11593.8 EFA78248.1 - 8.1 5.5 16.4 11 5.1 16.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal tRNA_bind PF01588.20 EFA78249.1 - 2e-28 98.4 0.2 3.7e-28 97.5 0.2 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EFA78249.1 - 0.046 13.7 0.0 0.099 12.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF5575 PF17738.1 EFA78249.1 - 0.12 11.3 0.1 0.42 9.6 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5575) Ribosomal_L3 PF00297.22 EFA78250.1 - 6.4e-178 591.4 9.0 7.3e-178 591.2 9.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF4473 PF14747.6 EFA78252.1 - 0.28 11.8 1.6 0.96 10.0 1.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) zf-RVT PF13966.6 EFA78253.1 - 0.014 16.1 2.7 0.036 14.8 2.7 1.7 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase Tim44 PF04280.15 EFA78253.1 - 0.15 12.2 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Tim44-like domain Ribosomal_L3 PF00297.22 EFA78255.1 - 1.1e-11 44.4 0.0 1.4e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Fer2_4 PF13510.6 EFA78257.1 - 0.097 12.7 0.2 1.7 8.8 0.0 2.1 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain PBP3 PF18056.1 EFA78257.1 - 0.14 12.3 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Penicillin Binding Protein 3 Domain Prot_inhib_II PF02428.15 EFA78258.1 - 0.59 10.6 8.3 0.22 12.0 5.1 1.7 2 0 0 2 2 2 0 Potato type II proteinase inhibitor family PABP PF00658.18 EFA78259.1 - 1.3e-10 41.3 0.8 2e-10 40.7 0.8 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Menin PF05053.13 EFA78259.1 - 0.059 11.7 5.3 0.062 11.7 5.3 1.0 1 0 0 1 1 1 0 Menin MGC-24 PF05283.11 EFA78259.1 - 0.71 10.3 6.3 1.3 9.5 6.3 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TFIIA PF03153.13 EFA78259.1 - 6.3 6.7 13.9 7.2 6.5 13.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.22 EFA78260.1 - 2.2e-69 229.2 1.6 3e-18 65.4 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA78260.1 - 1.4e-07 31.2 0.2 0.00059 19.4 0.2 3.6 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFA78260.1 - 0.0034 17.4 0.5 2 8.6 0.0 3.8 4 0 0 4 4 4 1 Limkain b1 RRM_7 PF16367.5 EFA78260.1 - 0.0042 17.2 0.1 10 6.3 0.1 3.9 3 1 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EFA78260.1 - 0.031 14.3 0.9 38 4.4 0.0 4.0 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif DUF2672 PF10878.8 EFA78260.1 - 0.3 11.1 2.2 11 6.1 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2672) Ras PF00071.22 EFA78261.1 - 1.3e-50 171.2 0.5 1.6e-50 170.9 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA78261.1 - 2.5e-18 66.4 0.0 4.5e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78261.1 - 1.2e-08 34.6 0.3 1.5e-08 34.3 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA78261.1 - 0.00012 21.7 0.3 0.00018 21.1 0.2 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA78261.1 - 0.016 15.3 0.1 0.028 14.5 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA78261.1 - 0.046 13.6 0.2 0.47 10.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase FNIP PF05725.12 EFA78262.1 - 7e-37 125.3 10.6 4.3e-12 46.0 0.0 6.9 3 1 4 7 7 7 7 FNIP Repeat F-box_5 PF18511.1 EFA78262.1 - 0.0095 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 F-box ArfGap PF01412.18 EFA78263.1 - 3.9e-30 104.3 0.4 3.9e-30 104.3 0.4 2.8 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf AAA_21 PF13304.6 EFA78263.1 - 1.7 8.4 11.1 0.42 10.4 8.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Methyltransf_12 PF08242.12 EFA78264.1 - 0.011 16.4 1.1 0.011 16.4 1.1 3.4 3 1 0 3 3 3 0 Methyltransferase domain Mucin PF01456.17 EFA78265.1 - 0.0016 18.4 0.4 0.0023 17.9 0.4 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF3439 PF11921.8 EFA78265.1 - 0.0033 17.4 0.8 0.0053 16.7 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 EFA78265.1 - 0.005 14.9 3.5 0.0063 14.6 3.5 1.0 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Sld7_N PF18636.1 EFA78265.1 - 0.096 13.0 0.6 0.16 12.3 0.2 1.6 2 0 0 2 2 2 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain CBM49 PF09478.10 EFA78266.1 - 9.7e-16 57.9 0.3 1.4e-15 57.3 0.3 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 PH PF00169.29 EFA78267.1 - 0.00033 21.1 0.2 0.00033 21.1 0.2 3.2 3 1 0 3 3 3 1 PH domain CRCB PF02537.15 EFA78268.1 - 4.1e-17 62.3 7.9 5.7e-17 61.8 7.9 1.2 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) DUF656 PF04920.12 EFA78268.1 - 0.038 13.9 1.3 0.052 13.5 1.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF656) Phage_holin_3_6 PF07332.11 EFA78268.1 - 0.31 11.1 2.0 2.8 8.0 0.5 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Phage_holin_3_3 PF16083.5 EFA78268.1 - 0.39 10.9 5.2 0.35 11.0 3.3 1.9 1 1 1 2 2 2 0 LydA holin phage, holin superfamily III Phage_tail_X PF05489.12 EFA78269.1 - 0.032 13.9 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 Phage Tail Protein X Ank_4 PF13637.6 EFA78269.1 - 0.033 14.8 0.1 28 5.4 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Syja_N PF02383.18 EFA78270.1 - 4.9e-83 279.1 0.0 4.9e-83 279.1 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain SelP_N PF04592.14 EFA78270.1 - 0.46 9.8 18.1 1.1 8.6 18.1 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Pkinase PF00069.25 EFA78271.1 - 1.6e-58 198.2 0.0 2.1e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78271.1 - 5e-45 153.8 0.0 7e-45 153.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA78271.1 - 0.006 16.5 0.0 0.05 13.5 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFA78271.1 - 0.012 15.2 0.0 4.7 6.8 0.0 2.4 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Ribosomal_S21e PF01249.18 EFA78273.1 - 8.7e-37 125.1 0.1 9.6e-37 125.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e DNA_pol3_delta2 PF13177.6 EFA78274.1 - 8.8e-13 48.3 0.0 1.7e-12 47.4 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EFA78274.1 - 4.7e-07 29.9 0.1 1.9e-06 27.9 0.0 1.8 1 1 0 2 2 2 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 EFA78274.1 - 2.3e-05 24.2 0.0 4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EFA78274.1 - 5.4e-05 23.6 0.1 0.00014 22.3 0.1 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA78274.1 - 0.00037 20.9 0.1 0.003 17.9 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EFA78274.1 - 0.0069 16.4 0.0 0.031 14.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFA78274.1 - 0.0087 15.3 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFA78274.1 - 0.017 15.4 0.0 0.038 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EFA78274.1 - 0.034 14.2 0.1 0.12 12.4 0.1 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Bac_DnaA PF00308.18 EFA78274.1 - 0.059 13.2 0.1 0.97 9.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial dnaA protein HsbA PF12296.8 EFA78274.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Hydrophobic surface binding protein A Mg_chelatase PF01078.21 EFA78274.1 - 0.18 11.1 0.2 1 8.7 0.1 2.3 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI His_Phos_1 PF00300.22 EFA78275.1 - 3e-26 92.3 0.0 2e-23 83.1 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) SURF6 PF04935.12 EFA78275.1 - 0.29 10.9 1.8 0.52 10.1 1.8 1.4 1 0 0 1 1 1 0 Surfeit locus protein 6 SPX PF03105.19 EFA78275.1 - 2.5 7.9 14.1 3.6 7.4 14.1 1.4 1 0 0 1 1 1 0 SPX domain Acyl-CoA_dh_1 PF00441.24 EFA78276.1 - 3.4e-47 160.4 0.6 5e-47 159.9 0.6 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFA78276.1 - 1.5e-26 93.2 0.0 2.8e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFA78276.1 - 1.7e-25 89.1 0.0 4e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFA78276.1 - 2.5e-21 76.3 0.1 4.3e-21 75.6 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Patatin PF01734.22 EFA78276.1 - 3.8e-17 63.2 0.1 4.5e-16 59.7 0.0 2.6 2 1 0 2 2 2 1 Patatin-like phospholipase GATase_4 PF13230.6 EFA78277.1 - 3.3e-14 52.5 0.0 4.3e-13 48.8 0.0 2.0 1 1 1 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EFA78277.1 - 2.2e-11 44.1 0.0 5e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain ABC_membrane PF00664.23 EFA78278.1 - 3.2e-54 184.5 31.5 9.9e-37 127.1 18.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA78278.1 - 1.1e-47 162.0 0.0 9.3e-28 97.4 0.0 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA78278.1 - 5e-11 42.5 0.2 0.00066 19.2 0.1 4.0 2 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA78278.1 - 6.9e-05 22.8 2.4 1.8 8.3 0.1 4.2 2 2 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA78278.1 - 0.00068 19.6 0.1 0.14 12.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFA78278.1 - 0.00083 19.4 5.2 0.63 10.1 0.1 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA78278.1 - 0.0013 18.5 1.1 1.3 8.8 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EFA78278.1 - 0.0021 18.6 5.7 1.3 9.4 2.6 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA78278.1 - 0.0035 17.8 0.0 0.06 13.7 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EFA78278.1 - 0.005 17.4 1.0 2.3 8.8 0.3 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFA78278.1 - 0.0061 16.2 0.1 0.11 12.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFA78278.1 - 0.0068 15.5 0.5 4 6.4 0.0 3.1 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_7 PF12775.7 EFA78278.1 - 0.008 15.7 0.7 0.26 10.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EFA78278.1 - 0.0089 15.8 0.0 1.9 8.2 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA PF00004.29 EFA78278.1 - 0.0093 16.4 0.1 0.66 10.4 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EFA78278.1 - 0.019 15.1 6.1 0.33 11.0 0.2 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_22 PF13401.6 EFA78278.1 - 0.045 14.0 2.8 2.3 8.5 0.6 3.0 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EFA78278.1 - 0.049 12.5 0.6 6 5.7 0.2 2.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 EFA78278.1 - 0.061 13.0 0.1 3.9 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EFA78278.1 - 0.17 11.8 3.1 1.8 8.5 0.2 3.4 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 EFA78278.1 - 0.23 11.9 0.7 8.1 6.9 0.1 2.9 2 0 0 2 2 2 0 RNA helicase Roc PF08477.13 EFA78278.1 - 4.2 7.6 5.9 6.6 7.0 0.2 3.1 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase NdhM PF10664.9 EFA78280.1 - 0.056 13.7 0.2 0.097 12.9 0.1 1.4 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M ADH_zinc_N_2 PF13602.6 EFA78281.1 - 9.9e-19 68.7 0.0 1.9e-18 67.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFA78281.1 - 2.7e-12 46.8 0.0 5.6e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA78281.1 - 2.3e-10 40.3 1.1 2.3e-10 40.3 1.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF3730 PF12530.8 EFA78281.1 - 0.075 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) DUF4061 PF13270.6 EFA78281.1 - 0.15 12.3 0.2 0.27 11.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) YmcE_antitoxin PF15939.5 EFA78282.1 - 0.093 12.9 2.0 0.13 12.5 2.0 1.2 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system RasGEF PF00617.19 EFA78283.1 - 1.5e-52 178.4 1.0 1.4e-51 175.2 0.8 2.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFA78283.1 - 1.4e-06 28.5 0.5 1.4e-06 28.5 0.5 5.0 4 0 0 4 4 4 1 RasGEF N-terminal motif Peptidase_S49_N PF08496.10 EFA78283.1 - 0.08 13.0 0.7 4.6 7.3 0.0 2.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ribosomal_L29 PF00831.23 EFA78283.1 - 0.33 11.0 4.4 0.74 9.8 1.2 3.1 2 0 0 2 2 2 0 Ribosomal L29 protein Glyco_hydro_71 PF03659.14 EFA78284.1 - 1e-25 90.4 4.0 1.8e-25 89.6 4.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 71 CMS1 PF14617.6 EFA78285.1 - 3.3e-18 65.9 4.5 7.4e-18 64.8 4.5 1.6 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit zf-CCHC PF00098.23 EFA78285.1 - 2.4e-05 24.2 12.5 0.0032 17.5 1.0 2.8 3 0 0 3 3 3 2 Zinc knuckle zf-C2H2_10 PF16588.5 EFA78285.1 - 0.017 14.8 0.3 0.017 14.8 0.3 2.3 2 0 0 2 2 2 0 C2H2 zinc-finger Nop14 PF04147.12 EFA78285.1 - 0.018 13.3 13.7 0.028 12.6 13.7 1.2 1 0 0 1 1 1 0 Nop14-like family DEAD PF00270.29 EFA78285.1 - 0.018 14.8 0.1 0.049 13.4 0.1 1.8 2 0 0 2 2 2 0 DEAD/DEAH box helicase FoP_duplication PF13865.6 EFA78285.1 - 0.02 15.4 16.2 0.039 14.5 15.4 1.9 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 zf-CCHC_2 PF13696.6 EFA78285.1 - 0.033 14.0 7.1 1.1 9.2 1.9 2.5 2 0 0 2 2 2 0 Zinc knuckle Stevor PF17410.2 EFA78285.1 - 0.046 13.3 1.8 0.071 12.7 1.8 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame GP120 PF00516.18 EFA78285.1 - 0.3 9.6 2.8 0.48 9.0 2.8 1.2 1 0 0 1 1 1 0 Envelope glycoprotein GP120 zf-CCHC_4 PF14392.6 EFA78285.1 - 2.8 7.8 7.4 8.6 6.2 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle ELMO_CED12 PF04727.13 EFA78286.1 - 8.8e-44 149.7 0.3 1.3e-43 149.2 0.3 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family DEAD PF00270.29 EFA78287.1 - 1.4e-45 155.2 0.0 3.1e-45 154.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA78287.1 - 1.8e-24 86.2 0.0 9.2e-24 83.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFA78287.1 - 7.5e-17 61.3 0.1 1.7e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFA78287.1 - 2.6e-07 30.8 0.0 2.6e-07 30.8 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA78288.1 - 1.2e-47 162.0 0.1 4.4e-47 160.1 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA78288.1 - 1.5e-30 105.8 0.7 2.4e-29 101.9 0.0 3.0 3 1 1 4 4 4 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFA78288.1 - 5.8e-07 29.0 0.1 1.1e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HSP90 PF00183.18 EFA78289.1 - 8.3e-183 609.0 27.9 1.3e-182 608.4 27.9 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFA78289.1 - 1.1e-09 38.8 0.3 2.4e-09 37.7 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFA78289.1 - 3.6e-09 36.6 0.2 1.4e-08 34.7 0.2 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DELLA PF12041.8 EFA78289.1 - 0.19 11.7 1.0 3.9 7.4 0.0 2.6 1 1 1 2 2 2 0 Transcriptional regulator DELLA protein N terminal Ribosomal_S8e PF01201.22 EFA78291.1 - 4e-50 169.5 2.9 5.2e-50 169.2 2.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e CBM49 PF09478.10 EFA78292.1 - 1.2e-15 57.5 0.2 1.8e-15 57.0 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Ribosomal_L24e PF01246.20 EFA78293.1 - 6.8e-27 93.5 0.3 1.9e-26 92.1 0.3 1.8 1 0 0 1 1 1 1 Ribosomal protein L24e DDHD PF02862.17 EFA78293.1 - 0.28 11.3 3.3 0.34 11.1 3.3 1.1 1 0 0 1 1 1 0 DDHD domain Cpn60_TCP1 PF00118.24 EFA78294.1 - 5.4e-52 177.0 1.5 4.3e-47 160.9 0.1 2.1 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family SepSecS PF05889.13 EFA78295.1 - 1.5e-122 409.0 0.4 1.8e-122 408.8 0.4 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 EFA78295.1 - 0.12 11.7 0.0 0.37 10.0 0.0 1.7 1 1 1 2 2 2 0 Beta-eliminating lyase WW PF00397.26 EFA78296.1 - 2e-23 82.1 10.0 4.7e-12 45.8 1.3 2.7 3 0 0 3 3 3 2 WW domain ACT_4 PF13291.6 EFA78296.1 - 0.048 14.3 0.3 0.22 12.1 0.1 2.0 1 1 0 2 2 2 0 ACT domain IQ PF00612.27 EFA78296.1 - 0.11 12.3 0.1 0.29 11.0 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif IPP-2 PF04979.14 EFA78296.1 - 0.15 12.8 0.0 0.26 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase inhibitor 2 (IPP-2) FAT PF02259.23 EFA78297.1 - 6e-42 144.1 0.3 6e-42 144.1 0.3 3.0 2 0 0 2 2 2 1 FAT domain Bact_lectin PF18483.1 EFA78297.1 - 1.1e-11 45.1 1.8 1.1e-11 45.1 1.8 3.2 3 0 0 3 3 3 1 Bacterial lectin Spt20 PF12090.8 EFA78297.1 - 0.032 13.9 25.9 1 9.0 27.8 2.6 2 0 0 2 2 2 0 Spt20 family UPF0524 PF15823.5 EFA78297.1 - 0.065 12.6 0.8 0.19 11.1 0.8 1.7 1 0 0 1 1 1 0 UPF0524 of C3orf70 Virul_Fac PF10139.9 EFA78297.1 - 0.066 11.4 7.0 0.14 10.3 7.0 1.4 1 0 0 1 1 1 0 Putative bacterial virulence factor MPM1 PF17234.2 EFA78297.1 - 0.1 12.9 14.4 0.068 13.4 12.2 1.8 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 EIF4E-T PF10477.9 EFA78297.1 - 0.11 11.3 15.2 0.22 10.3 15.2 1.4 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E SKA1 PF07160.12 EFA78297.1 - 1.9 8.3 11.0 9.9 5.9 11.0 2.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Hist_deacetyl PF00850.19 EFA78298.1 - 6.5e-73 245.9 0.1 6.5e-73 245.9 0.1 2.0 2 0 0 2 2 2 1 Histone deacetylase domain RBR PF17208.3 EFA78298.1 - 0.06 14.1 0.1 0.06 14.1 0.1 4.3 4 1 0 4 4 4 0 RNA binding Region Mucin PF01456.17 EFA78298.1 - 2.2 8.3 55.6 0.73 9.8 17.1 3.6 3 0 0 3 3 3 0 Mucin-like glycoprotein zf-RING_2 PF13639.6 EFA78298.1 - 3.4 8.1 7.9 9.7 6.6 7.9 1.8 1 0 0 1 1 1 0 Ring finger domain EamA PF00892.20 EFA78299.1 - 3e-10 40.4 36.3 1.7e-07 31.5 4.8 3.2 3 0 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EFA78299.1 - 0.0012 18.4 3.0 0.0014 18.2 1.4 1.8 2 0 0 2 2 2 1 Solute carrier family 35 IlvGEDA_leader PF08046.11 EFA78299.1 - 0.1 12.0 0.2 0.1 12.0 0.2 2.1 2 0 0 2 2 2 0 IlvGEDA operon leader peptide AMP-binding PF00501.28 EFA78300.1 - 3e-74 250.1 0.0 5.3e-74 249.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFA78300.1 - 1.5e-28 99.7 0.1 2.5e-28 98.9 0.1 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EFA78300.1 - 0.00015 22.0 0.1 0.0003 21.1 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFA78300.1 - 0.035 15.1 0.0 0.071 14.1 0.0 1.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Iso_dh PF00180.20 EFA78301.1 - 3.8e-106 355.2 0.0 4.7e-106 354.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.12 EFA78301.1 - 0.1 12.0 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA GREB1 PF15782.5 EFA78303.1 - 0.011 13.0 0.0 0.014 12.5 0.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LRR_8 PF13855.6 EFA78304.1 - 1.5e-21 75.9 30.2 1.7e-08 34.1 7.1 5.2 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFA78304.1 - 1.1e-15 57.5 53.8 0.00011 22.5 4.6 7.6 4 2 5 9 9 9 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFA78304.1 - 0.2 11.8 28.5 2.4 8.4 0.7 8.6 8 0 0 8 8 8 0 Leucine Rich repeat LRR_3 PF07725.12 EFA78304.1 - 0.26 11.2 2.6 0.69 9.9 0.2 3.0 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_9 PF14580.6 EFA78304.1 - 0.77 9.2 18.5 0.047 13.2 1.5 3.9 3 1 0 4 4 4 0 Leucine-rich repeat Fcf1 PF04900.12 EFA78305.1 - 0.077 13.4 0.7 0.077 13.4 0.7 1.7 2 0 0 2 2 2 0 Fcf1 Ribosomal_L27e PF01777.18 EFA78306.1 - 1.1e-29 102.6 8.3 1.4e-29 102.3 8.3 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family PRK PF00485.18 EFA78307.1 - 7.8e-18 64.9 1.1 1.1e-15 57.9 1.1 2.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CYTH PF01928.21 EFA78307.1 - 3.1e-14 53.3 0.2 9.9e-14 51.7 0.0 1.8 2 0 0 2 2 2 1 CYTH domain AAA_18 PF13238.6 EFA78307.1 - 0.00016 22.2 1.3 0.0013 19.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFA78307.1 - 0.0011 19.5 0.6 0.0071 16.9 0.0 2.6 2 0 0 2 2 2 1 ABC transporter KAP_NTPase PF07693.14 EFA78307.1 - 0.0017 17.6 2.4 0.0029 16.9 0.0 2.2 2 0 0 2 2 2 1 KAP family P-loop domain NB-ARC PF00931.22 EFA78307.1 - 0.0023 17.2 0.0 0.0059 15.8 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_24 PF13479.6 EFA78307.1 - 0.0074 16.0 0.0 0.0074 16.0 0.0 2.6 3 1 0 3 3 3 1 AAA domain TsaE PF02367.17 EFA78307.1 - 0.014 15.3 0.2 0.12 12.4 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_21 PF13304.6 EFA78307.1 - 0.053 13.3 1.3 0.14 11.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system CoaE PF01121.20 EFA78307.1 - 0.12 12.1 0.1 0.12 12.1 0.1 2.5 4 0 0 4 4 4 0 Dephospho-CoA kinase AAA_17 PF13207.6 EFA78307.1 - 0.17 12.3 1.4 2.1 8.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain zf-RING_2 PF13639.6 EFA78308.1 - 2.9e-13 49.9 7.1 4.3e-13 49.4 7.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFA78308.1 - 1.5e-09 37.4 3.8 2.9e-09 36.5 3.8 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFA78308.1 - 1e-07 31.7 8.4 1.6e-07 31.1 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA78308.1 - 7.6e-07 29.3 11.5 3.6e-06 27.2 11.5 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA78308.1 - 1.7e-06 27.8 4.2 2.5e-06 27.2 4.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA78308.1 - 4.2e-06 26.5 9.2 7.2e-06 25.8 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA78308.1 - 1.7e-05 24.7 5.4 3e-05 24.0 5.4 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EFA78308.1 - 9e-05 22.5 1.0 0.00014 21.8 1.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EFA78308.1 - 0.0015 18.4 6.5 0.0025 17.7 6.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFA78308.1 - 0.013 15.3 5.5 0.023 14.6 5.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EFA78308.1 - 0.025 14.2 6.4 0.047 13.3 6.4 1.5 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H_2 PF13832.6 EFA78308.1 - 0.027 14.6 0.9 0.044 14.0 0.9 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-C3H2C3 PF17122.5 EFA78308.1 - 0.029 14.4 6.3 0.088 12.9 6.3 1.8 1 1 0 1 1 1 0 Zinc-finger zf-RING_10 PF16685.5 EFA78308.1 - 0.031 14.4 2.5 0.05 13.7 2.5 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EFA78308.1 - 0.04 13.7 5.9 0.081 12.7 5.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain UPF0547 PF10571.9 EFA78308.1 - 0.042 13.9 0.2 0.091 12.9 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 RINGv PF12906.7 EFA78308.1 - 0.044 13.9 4.2 0.1 12.7 4.2 1.7 1 1 0 1 1 1 0 RING-variant domain zf-C3HC4_4 PF15227.6 EFA78308.1 - 0.25 11.6 4.9 0.71 10.1 4.9 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 EFA78308.1 - 0.85 9.8 8.8 21 5.4 8.8 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 EFA78308.1 - 0.94 9.8 8.0 1.9 8.9 8.0 1.6 1 1 0 1 1 1 0 RING-like domain zf-P11 PF03854.14 EFA78308.1 - 1.1 9.0 7.4 0.29 10.8 3.3 1.9 1 1 1 2 2 2 0 P-11 zinc finger GSH_synth_ATP PF03917.17 EFA78309.1 - 1.5e-119 399.1 0.1 1.9e-119 398.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EFA78309.1 - 5.9e-24 84.5 1.3 1.7e-22 79.8 0.1 3.2 2 1 0 2 2 2 1 Eukaryotic glutathione synthase DNA_repr_REX1B PF14966.6 EFA78309.1 - 0.089 13.5 0.3 6.2 7.6 0.1 2.6 2 0 0 2 2 2 0 DNA repair REX1-B DUF3430 PF11912.8 EFA78310.1 - 1.8e-13 51.1 15.3 2e-13 50.9 15.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) DEAD PF00270.29 EFA78311.1 - 6.5e-50 169.3 0.0 1.7e-49 168.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA78311.1 - 3.8e-30 104.5 0.5 2.2e-28 98.8 0.2 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain WD40 PF00400.32 EFA78311.1 - 2.2e-09 37.8 3.8 1.2e-05 25.9 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat SpoIIIAH PF12685.7 EFA78311.1 - 0.0088 15.9 14.2 0.01 15.7 3.1 2.5 2 0 0 2 2 2 1 SpoIIIAH-like protein Mem_trans PF03547.18 EFA78311.1 - 0.05 12.0 3.0 0.25 9.7 1.2 2.1 2 0 0 2 2 2 0 Membrane transport protein DDHD PF02862.17 EFA78311.1 - 0.065 13.4 6.4 1.6 8.9 0.7 2.4 2 0 0 2 2 2 0 DDHD domain Ureide_permease PF07168.11 EFA78311.1 - 0.23 10.2 7.0 0.44 9.3 2.0 2.3 2 0 0 2 2 2 0 Ureide permease DUF4746 PF15928.5 EFA78311.1 - 1.3 8.3 13.3 0.65 9.4 6.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) FAM176 PF14851.6 EFA78311.1 - 1.9 8.2 14.9 0.45 10.2 2.6 2.5 2 0 0 2 2 2 0 FAM176 family Presenilin PF01080.17 EFA78311.1 - 2.6 6.7 16.8 0.25 10.1 1.7 2.2 2 0 0 2 2 2 0 Presenilin Pol_alpha_B_N PF08418.10 EFA78311.1 - 4.3 7.2 20.4 3.7 7.5 2.5 2.4 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF702 PF05142.12 EFA78311.1 - 5.3 7.5 12.3 4.3 7.8 5.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) TRAP_alpha PF03896.16 EFA78311.1 - 7.5 5.7 10.6 0.84 8.8 0.3 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Ctr PF04145.15 EFA78311.1 - 8 7.1 6.8 4.4 7.9 0.2 2.5 2 0 0 2 2 2 0 Ctr copper transporter family Connexin PF00029.19 EFA78311.1 - 8.7 6.0 11.9 0.74 9.5 1.2 2.2 2 0 0 2 2 2 0 Connexin Lipase_GDSL PF00657.22 EFA78312.1 - 4e-08 33.5 0.0 6.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.17 EFA78312.1 - 2.3e-06 27.6 3.0 2.7e-06 27.4 1.1 2.2 2 0 0 2 2 2 1 Saposin-like type B, region 2 Cu-binding_MopE PF11617.8 EFA78312.1 - 0.0031 17.6 2.1 0.0031 17.6 2.1 2.4 2 1 0 2 2 2 1 Putative metal-binding motif DUF3791 PF12668.7 EFA78312.1 - 0.056 13.5 0.2 0.41 10.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) SapB_2 PF03489.17 EFA78313.1 - 2.6e-06 27.4 0.2 1.6e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Saposin-like type B, region 2 Lipase_GDSL_2 PF13472.6 EFA78313.1 - 1.4e-05 25.5 0.2 3e-05 24.5 0.2 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Cu-binding_MopE PF11617.8 EFA78313.1 - 0.0022 18.1 3.0 0.006 16.7 3.0 1.8 1 0 0 1 1 1 1 Putative metal-binding motif SapB_1 PF05184.15 EFA78313.1 - 0.27 11.3 4.3 0.13 12.3 0.6 2.5 2 1 0 2 2 2 0 Saposin-like type B, region 1 CDP-OH_P_transf PF01066.21 EFA78314.1 - 7.4e-08 33.1 1.4 7.4e-08 33.1 1.4 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF5412 PF17428.2 EFA78314.1 - 0.022 14.6 0.4 0.065 13.1 0.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5412) SR-25 PF10500.9 EFA78314.1 - 1.5 8.4 8.4 2.4 7.7 8.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Myotub-related PF06602.14 EFA78315.1 - 2e-141 471.0 0.3 2e-141 471.0 0.3 2.2 3 0 0 3 3 3 1 Myotubularin-like phosphatase domain Kelch_4 PF13418.6 EFA78315.1 - 2e-05 24.5 0.1 8.5e-05 22.5 0.1 2.1 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA78315.1 - 2.5e-05 24.4 1.0 0.017 15.4 0.1 3.9 2 1 1 3 3 3 1 Kelch motif DUF2616 PF11077.8 EFA78315.1 - 0.00011 21.9 0.5 0.00033 20.4 0.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2616) GRAM PF02893.20 EFA78315.1 - 0.00028 20.7 0.7 0.0021 17.9 0.7 2.6 1 0 0 1 1 1 1 GRAM domain zf-B_box PF00643.24 EFA78315.1 - 0.0021 18.2 5.2 0.0055 16.8 5.2 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA78315.1 - 0.0061 16.1 0.0 0.02 14.5 0.0 2.0 1 0 0 1 1 1 1 Kelch motif 3-PAP PF12578.8 EFA78315.1 - 0.061 13.1 3.0 0.092 12.5 0.0 2.9 2 0 0 2 2 2 0 Myotubularin-associated protein Oxysterol_BP PF01237.18 EFA78316.1 - 2e-111 372.5 2.8 2.6e-111 372.1 2.8 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Med2 PF11214.8 EFA78316.1 - 0.0073 16.4 0.7 0.018 15.2 0.7 1.6 1 0 0 1 1 1 1 Mediator complex subunit 2 Condensin2nSMC PF12422.8 EFA78317.1 - 4.6e-17 62.6 1.8 8.9e-17 61.7 0.1 2.5 3 0 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit FAM176 PF14851.6 EFA78317.1 - 0.001 18.7 20.1 0.0031 17.2 2.8 4.3 4 0 0 4 4 4 2 FAM176 family RasGAP PF00616.19 EFA78317.1 - 0.015 15.0 10.0 0.6 9.8 0.9 3.1 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase Sigma70_ner PF04546.13 EFA78317.1 - 0.11 12.4 20.3 0.76 9.6 1.9 4.2 4 0 0 4 4 4 0 Sigma-70, non-essential region Ribosomal_60s PF00428.19 EFA78317.1 - 0.14 12.8 8.1 4.9 7.8 1.6 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4820 PF16091.5 EFA78317.1 - 0.18 11.1 9.8 3.6 6.9 2.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) RXT2_N PF08595.11 EFA78317.1 - 0.4 10.7 24.4 0.22 11.5 3.7 4.7 4 0 0 4 4 4 0 RXT2-like, N-terminal dsRBD2 PF17842.1 EFA78317.1 - 0.41 10.9 9.8 0.6 10.3 1.1 3.9 4 0 0 4 4 4 0 Double-stranded RNA binding domain 2 Pex24p PF06398.11 EFA78317.1 - 0.54 9.2 7.2 0.1 11.6 0.1 2.7 3 0 0 3 3 3 0 Integral peroxisomal membrane peroxin RPA43_OB PF17875.1 EFA78317.1 - 6.9 7.3 10.2 47 4.6 0.5 3.5 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I GTP_cyclohydroI PF01227.22 EFA78319.1 - 1.4e-75 252.7 0.2 1.7e-75 252.4 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EFA78319.1 - 0.0044 17.1 0.0 0.011 15.9 0.0 1.7 2 0 0 2 2 2 1 QueF-like protein HATPase_c_2 PF13581.6 EFA78319.1 - 0.045 13.7 0.4 0.14 12.1 0.1 1.9 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain His_Phos_2 PF00328.22 EFA78319.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) IF3_C PF00707.22 EFA78320.1 - 5.3e-08 32.7 0.1 2.3e-07 30.7 0.1 2.2 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain FragX_IP PF05994.11 EFA78321.1 - 0 1025.5 9.6 0 1024.9 9.6 1.3 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 EFA78321.1 - 3.3e-17 62.7 6.9 8.7e-17 61.3 6.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) WXG100 PF06013.12 EFA78321.1 - 0.022 15.0 2.5 14 6.0 0.0 3.8 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Myosin_N PF02736.19 EFA78322.1 - 0.13 12.1 1.9 6.2 6.7 0.1 4.2 2 1 2 4 4 4 0 Myosin N-terminal SH3-like domain DUF4476 PF14771.6 EFA78323.1 - 8.2e-19 67.7 2.1 9e-19 67.6 2.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) CAF-1_p150 PF11600.8 EFA78324.1 - 0.0071 16.1 56.1 0.0071 16.1 56.1 3.7 3 2 2 5 5 5 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Asparaginase_2 PF01112.18 EFA78327.1 - 9.6e-116 386.1 8.9 1.1e-115 385.9 8.9 1.0 1 0 0 1 1 1 1 Asparaginase DUF2117 PF09890.9 EFA78327.1 - 0.019 14.5 0.2 0.035 13.6 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) DHHC PF01529.20 EFA78329.1 - 1.4e-36 125.5 7.7 1.4e-36 125.5 7.7 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Mcm10 PF09332.11 EFA78329.1 - 0.012 15.0 0.5 0.016 14.6 0.5 1.1 1 0 0 1 1 1 0 Mcm10 replication factor TMEM43 PF07787.12 EFA78329.1 - 1.7 7.9 6.9 0.36 10.2 0.2 2.4 2 0 0 2 2 2 0 Transmembrane protein 43 TIG PF01833.24 EFA78330.1 - 1.8e-19 69.6 55.7 1.1e-06 28.6 3.5 7.2 8 1 1 9 9 9 5 IPT/TIG domain Lectin_C PF00059.21 EFA78330.1 - 0.00017 22.3 0.4 0.0006 20.5 0.4 2.0 1 1 0 1 1 1 1 Lectin C-type domain EGF_2 PF07974.13 EFA78330.1 - 0.0012 19.1 13.3 0.0038 17.6 13.3 1.9 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA78330.1 - 0.064 13.6 3.7 0.16 12.3 3.7 1.6 1 0 0 1 1 1 0 EB module TMEM154 PF15102.6 EFA78330.1 - 0.074 13.0 1.6 0.18 11.7 1.6 1.6 1 0 0 1 1 1 0 TMEM154 protein family hEGF PF12661.7 EFA78330.1 - 7.1 7.4 10.9 4.2 8.2 7.6 2.4 2 0 0 2 2 2 0 Human growth factor-like EGF SYS1 PF09801.9 EFA78331.1 - 1.3e-46 158.3 10.5 1.6e-46 158.1 10.5 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network K_trans PF02705.16 EFA78331.1 - 0.022 13.3 2.4 0.028 12.9 2.4 1.2 1 1 0 1 1 1 0 K+ potassium transporter DUF997 PF06196.12 EFA78331.1 - 0.77 9.8 7.4 0.24 11.4 2.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF997) RNase_PH PF01138.21 EFA78332.1 - 9.7e-33 113.5 0.1 1.3e-32 113.1 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFA78332.1 - 0.0041 17.1 0.1 0.23 11.5 0.1 2.6 3 0 0 3 3 3 1 3' exoribonuclease family, domain 2 PDCD2_C PF04194.13 EFA78333.1 - 1.3e-26 93.7 49.4 3e-20 73.0 49.4 3.6 1 1 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Ndc1_Nup PF09531.10 EFA78333.1 - 0.13 11.0 8.1 0.18 10.5 8.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ESM4 PF15952.5 EFA78333.1 - 1.1 9.7 28.3 1.8 8.9 7.2 2.2 2 0 0 2 2 2 0 Enhancer of split M4 family LAP1C PF05609.12 EFA78333.1 - 3.7 6.5 28.6 4.9 6.1 28.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF572 PF04502.13 EFA78333.1 - 5.1 6.6 32.7 7.4 6.1 32.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ras PF00071.22 EFA78334.1 - 4.8e-33 114.0 3.1 1.5e-24 86.4 0.1 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFA78334.1 - 3e-21 75.9 0.3 5.1e-21 75.1 0.3 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78334.1 - 3.8e-07 29.7 0.7 6.6e-07 28.9 0.7 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA78334.1 - 5.5e-07 29.7 0.0 9.9e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA78334.1 - 0.003 17.1 0.1 0.17 11.4 0.1 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA78334.1 - 0.004 16.5 0.2 0.005 16.2 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA78334.1 - 0.013 15.4 0.1 0.041 13.8 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase Hemolysin_N PF12563.8 EFA78334.1 - 0.016 14.8 0.7 0.024 14.2 0.7 1.2 1 0 0 1 1 1 0 Hemolytic toxin N terminal DUF87 PF01935.17 EFA78334.1 - 0.022 14.9 0.2 3.3 7.7 0.5 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_16 PF13191.6 EFA78334.1 - 0.031 14.6 0.0 0.052 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFA78334.1 - 0.071 13.6 0.4 0.37 11.3 0.4 2.1 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 EFA78334.1 - 0.077 12.7 0.1 0.91 9.3 0.1 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Memo PF01875.17 EFA78335.1 - 7.5e-85 284.4 0.1 8.5e-85 284.2 0.1 1.0 1 0 0 1 1 1 1 Memo-like protein NUDIX_5 PF16705.5 EFA78335.1 - 0.13 12.0 0.0 0.37 10.5 0.0 1.6 2 0 0 2 2 2 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT zf-Tim10_DDP PF02953.15 EFA78336.1 - 1.1e-13 50.6 2.1 1.4e-13 50.3 2.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.9 EFA78336.1 - 0.015 15.3 4.7 0.026 14.5 0.6 2.1 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Crust_neurohorm PF01147.17 EFA78336.1 - 0.017 14.9 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Pyr_redox_2 PF07992.14 EFA78337.1 - 3e-49 167.8 0.0 3.7e-49 167.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA78337.1 - 8.8e-09 35.8 0.0 1.2e-07 32.2 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFA78337.1 - 0.034 14.4 0.0 15 5.9 0.0 3.1 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain PCB_OB PF17092.5 EFA78337.1 - 0.096 13.4 0.2 2.8 8.7 0.2 2.3 2 0 0 2 2 2 0 Penicillin-binding protein OB-like domain GMC_oxred_C PF05199.13 EFA78337.1 - 0.11 13.0 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 GMC oxidoreductase DUF4460 PF14687.6 EFA78338.1 - 3e-26 91.6 3.9 3e-26 91.6 3.9 3.6 4 1 1 5 5 5 2 Domain of unknown function (DUF4460) DUF4461 PF14688.6 EFA78338.1 - 1.7e-06 28.0 0.0 1.4e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4461) Ras PF00071.22 EFA78340.1 - 4.9e-34 117.3 0.0 6.5e-34 116.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA78340.1 - 1.1e-24 86.9 0.0 1.6e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78340.1 - 1.2e-15 57.4 0.0 1.5e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA78340.1 - 3.4e-07 29.9 0.0 4.2e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA78340.1 - 8.9e-06 25.8 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA78340.1 - 0.0032 17.0 0.0 0.01 15.4 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EFA78340.1 - 0.013 14.9 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 EFA78340.1 - 0.016 14.6 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFA78340.1 - 0.085 12.4 0.1 0.34 10.4 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_19 PF13245.6 EFA78340.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain GyrI-like PF06445.15 EFA78341.1 - 3.1e-30 105.5 0.2 3.4e-30 105.4 0.2 1.0 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 EFA78341.1 - 2.3e-11 44.1 0.5 3.1e-11 43.7 0.5 1.1 1 0 0 1 1 1 1 Integron-associated effector binding protein GTP_EFTU PF00009.27 EFA78342.1 - 6.4e-24 84.6 0.1 3.7e-22 78.8 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA78342.1 - 0.05 13.7 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_32 PF13654.6 EFA78342.1 - 0.066 12.0 0.0 0.14 10.9 0.0 1.5 2 0 0 2 2 2 0 AAA domain Glyco_hydro_cc PF11790.8 EFA78343.1 - 6.5e-51 173.2 1.4 8.8e-51 172.8 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Sporozoite_P67 PF05642.11 EFA78343.1 - 0.0093 14.1 0.5 0.0089 14.2 0.5 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen TMEM154 PF15102.6 EFA78343.1 - 0.57 10.1 3.6 0.3 11.0 0.4 1.9 2 0 0 2 2 2 0 TMEM154 protein family Mucin PF01456.17 EFA78344.1 - 0.21 11.6 17.1 0.48 10.4 17.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EFA78344.1 - 1.9 8.5 10.0 4.2 7.4 10.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Chalcone_2 PF16035.5 EFA78345.1 - 2e-10 40.8 5.4 2.1e-06 27.6 0.3 2.5 2 1 1 3 3 3 2 Chalcone isomerase like Chalcone_3 PF16036.5 EFA78345.1 - 0.021 14.9 0.1 0.77 9.9 0.0 2.3 1 1 1 2 2 2 0 Chalcone isomerase-like Rib_5-P_isom_A PF06026.14 EFA78346.1 - 1.7e-64 216.6 0.1 2.2e-64 216.2 0.1 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Sugar-bind PF04198.13 EFA78346.1 - 0.018 14.2 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain FYVE PF01363.21 EFA78347.1 - 2.9e-19 69.0 10.5 5e-19 68.2 10.5 1.4 1 0 0 1 1 1 1 FYVE zinc finger Arrestin_N PF00339.29 EFA78347.1 - 1.7e-16 60.6 0.2 9e-12 45.3 0.1 3.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFA78347.1 - 1e-15 58.3 0.0 7e-14 52.4 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 EFA78347.1 - 2.2e-06 27.1 0.1 0.039 13.1 0.0 3.5 2 1 2 4 4 4 2 Rgp1 FYVE_2 PF02318.16 EFA78347.1 - 0.088 13.0 7.1 0.19 11.9 7.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Ribonuc_red_sm PF00268.21 EFA78348.1 - 1.8e-119 398.3 3.4 2.1e-119 398.1 3.4 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain BCLP PF12304.8 EFA78348.1 - 0.17 11.4 0.3 0.54 9.8 0.2 1.8 2 0 0 2 2 2 0 Beta-casein like protein Myosin_head PF00063.21 EFA78349.1 - 3.5e-250 831.9 7.4 4.4e-250 831.6 7.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFA78349.1 - 8.5e-43 146.2 1.5 1.5e-42 145.4 1.5 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EFA78349.1 - 2e-17 62.5 0.3 3.9e-17 61.6 0.3 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA78349.1 - 1.9e-15 56.4 0.1 4.1e-15 55.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA78349.1 - 5.9e-13 48.3 0.0 1.4e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.6 EFA78349.1 - 0.027 14.7 0.0 0.1 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA78349.1 - 0.03 14.7 0.0 0.077 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EFA78349.1 - 0.042 14.2 0.3 0.16 12.4 0.0 2.2 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 EFA78349.1 - 0.055 13.4 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EFA78349.1 - 0.057 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFA78349.1 - 0.082 12.2 0.7 0.19 11.0 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin TrwB_AAD_bind PF10412.9 EFA78349.1 - 0.15 10.9 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Hpr_kinase_C PF07475.12 EFA78349.1 - 0.22 11.0 0.5 4.7 6.7 0.0 2.7 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain Ank_4 PF13637.6 EFA78350.1 - 5.6e-16 58.7 0.7 2.7e-07 31.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78350.1 - 8.7e-15 54.6 2.2 7e-08 32.6 0.4 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA78350.1 - 1e-14 54.8 0.4 4.2e-07 30.5 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFA78350.1 - 2.6e-14 52.9 0.6 5.4e-06 26.6 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFA78350.1 - 2.3e-09 36.7 0.2 0.0023 18.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat HMG-CoA_red PF00368.18 EFA78352.1 - 4.7e-152 506.3 0.4 5.5e-152 506.0 0.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Lipase_GDSL PF00657.22 EFA78354.1 - 2.1e-06 27.9 0.3 3.4e-06 27.2 0.3 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Tegument_dsDNA PF12818.7 EFA78354.1 - 0.0088 15.2 1.2 0.015 14.5 1.2 1.4 1 0 0 1 1 1 1 dsDNA viral tegument protein Rep_fac_C PF08542.11 EFA78355.1 - 6.3e-23 81.0 0.0 1.9e-22 79.5 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EFA78355.1 - 1.1e-13 51.7 0.0 2.1e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFA78355.1 - 2.8e-12 46.7 0.0 5.8e-10 39.2 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 EFA78355.1 - 2.6e-07 30.7 0.0 4.5e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA78355.1 - 7.6e-07 29.5 0.1 0.0044 17.3 0.1 2.5 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 EFA78355.1 - 8.5e-07 29.1 0.0 2.2e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EFA78355.1 - 2e-06 28.3 0.0 0.00033 21.1 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EFA78355.1 - 6.4e-06 26.1 0.0 9.8e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EFA78355.1 - 5e-05 23.2 0.0 7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EFA78355.1 - 0.0002 21.7 0.0 0.00059 20.1 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain Mg_chelatase PF01078.21 EFA78355.1 - 0.00023 20.6 0.0 0.0034 16.8 0.0 2.4 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EFA78355.1 - 0.0013 18.7 0.2 0.06 13.3 0.1 2.3 1 1 0 2 2 2 1 NTPase AAA_24 PF13479.6 EFA78355.1 - 0.0015 18.2 0.0 0.0038 17.0 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.6 EFA78355.1 - 0.0017 18.7 0.2 0.014 15.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA78355.1 - 0.0021 17.8 0.0 0.0052 16.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 EFA78355.1 - 0.0027 17.5 0.2 0.56 9.9 0.0 2.7 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_5 PF07728.14 EFA78355.1 - 0.003 17.6 0.0 0.012 15.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EFA78355.1 - 0.0033 17.7 0.0 0.0061 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFA78355.1 - 0.0038 17.0 0.0 0.014 15.2 0.0 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFA78355.1 - 0.0039 17.5 0.0 0.041 14.3 0.0 2.2 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EFA78355.1 - 0.0043 17.6 0.0 0.01 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFA78355.1 - 0.0044 16.8 0.0 0.0081 15.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 EFA78355.1 - 0.0072 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region MCM PF00493.23 EFA78355.1 - 0.018 14.1 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ResIII PF04851.15 EFA78355.1 - 0.022 14.8 0.0 3.2 7.7 0.0 2.4 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit T2SSE PF00437.20 EFA78355.1 - 0.023 13.8 0.0 0.039 13.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 EFA78355.1 - 0.031 14.8 0.0 0.095 13.2 0.0 1.7 1 1 0 1 1 1 0 ABC transporter DNA_pol3_delta PF06144.13 EFA78355.1 - 0.032 14.0 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit TniB PF05621.11 EFA78355.1 - 0.032 13.6 0.1 4.6 6.6 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein DUF2075 PF09848.9 EFA78355.1 - 0.036 13.3 0.1 0.46 9.7 0.1 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EFA78355.1 - 0.071 13.0 0.0 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_3 PF07726.11 EFA78355.1 - 0.074 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFA78355.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EFA78355.1 - 0.089 12.4 0.1 0.32 10.5 0.1 1.9 1 1 1 2 2 2 0 AAA domain Closter_coat PF01785.17 EFA78356.1 - 0.0065 15.8 0.3 0.0065 15.8 0.3 1.1 1 0 0 1 1 1 1 Closterovirus coat protein CDC73_N PF16050.5 EFA78356.1 - 0.029 13.7 0.1 0.029 13.7 0.1 1.1 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal DUF4883 PF16224.5 EFA78356.1 - 0.036 14.3 0.3 0.042 14.1 0.3 1.2 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) HARE-HTH PF05066.13 EFA78356.1 - 0.088 13.2 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 HB1, ASXL, restriction endonuclease HTH domain Nramp PF01566.18 EFA78357.1 - 1.3e-133 445.4 23.3 1.3e-133 445.4 23.3 2.0 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Gemini_mov PF01708.16 EFA78357.1 - 3.5 7.4 7.1 23 4.8 0.2 3.1 2 0 0 2 2 2 0 Geminivirus putative movement protein RNA_pol_Rpb1_1 PF04997.12 EFA78358.1 - 3.4e-92 309.1 2.2 5.3e-92 308.5 2.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EFA78358.1 - 1.3e-85 287.1 1.0 1.8e-85 286.6 1.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFA78358.1 - 1.6e-75 252.9 0.0 3.9e-75 251.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFA78358.1 - 2.5e-34 118.5 0.1 3e-33 115.0 0.0 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFA78358.1 - 1.3e-31 108.7 0.0 5.7e-31 106.7 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 HATPase_c PF02518.26 EFA78359.1 - 2.3e-28 98.9 0.1 6.8e-28 97.4 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFA78359.1 - 4.6e-15 55.4 0.0 1.4e-14 53.9 0.0 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EFA78359.1 - 5.1e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EFA78359.1 - 0.0087 16.3 0.1 0.039 14.2 0.1 2.2 1 0 0 1 1 1 1 PAS domain GAGA_bind PF06217.12 EFA78361.1 - 0.21 11.8 12.1 0.25 11.6 12.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Spt20 PF12090.8 EFA78361.1 - 0.91 9.1 24.4 1.5 8.3 24.4 1.4 1 0 0 1 1 1 0 Spt20 family CytochromB561_N PF09786.9 EFA78361.1 - 4.2 6.2 10.7 5.1 6.0 10.7 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Androgen_recep PF02166.16 EFA78361.1 - 4.9 5.9 8.7 6.9 5.4 8.7 1.2 1 0 0 1 1 1 0 Androgen receptor V_ATPase_I PF01496.19 EFA78361.1 - 8.1 4.2 11.9 9.3 4.0 11.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CRAL_TRIO_2 PF13716.6 EFA78362.1 - 3.3e-49 166.6 1.1 4.7e-49 166.1 1.1 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EFA78362.1 - 7e-06 25.9 0.1 2.4e-05 24.1 0.1 1.9 1 1 0 1 1 1 1 CRAL/TRIO domain DSPc PF00782.20 EFA78363.1 - 3.7e-29 101.2 11.7 5.1e-29 100.8 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain SUIM_assoc PF16619.5 EFA78363.1 - 7.9e-07 29.1 0.5 15 5.8 0.0 2.4 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Zip PF02535.22 EFA78363.1 - 0.019 14.2 0.8 0.025 13.8 0.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter XRN_M PF17846.1 EFA78363.1 - 0.19 10.7 5.9 0.068 12.1 3.2 1.5 2 0 0 2 2 2 0 Xrn1 helical domain DUF4820 PF16091.5 EFA78363.1 - 1.9 7.8 8.9 2.7 7.3 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EOS1 PF12326.8 EFA78363.1 - 9.1 6.2 6.7 15 5.4 6.7 1.3 1 0 0 1 1 1 0 N-glycosylation protein HTH_28 PF13518.6 EFA78364.1 - 4.9e-06 26.6 0.5 1.1e-05 25.5 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 EFA78364.1 - 2e-05 24.3 0.0 5.6e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 EFA78364.1 - 9.5e-05 22.6 0.2 0.00072 19.8 0.2 2.6 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.6 EFA78364.1 - 0.00015 21.7 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 EFA78364.1 - 0.00018 20.9 0.0 0.00045 19.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 CENP-B_N PF04218.13 EFA78364.1 - 0.017 14.8 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_7 PF02796.15 EFA78364.1 - 0.1 12.7 0.2 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 EFA78364.1 - 4.1 7.5 7.9 0.19 11.7 0.2 2.9 3 0 0 3 3 3 0 Transposase COX5B PF01215.19 EFA78365.1 - 2.7e-13 49.7 0.0 3.1e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 EFA78365.1 - 0.018 15.1 0.3 0.028 14.5 0.3 1.3 1 0 0 1 1 1 0 Zinc-finger domain MFS_1 PF07690.16 EFA78366.1 - 4e-35 121.4 10.5 4e-35 121.4 10.5 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA78366.1 - 1.8e-14 53.5 2.0 1.8e-14 53.5 2.0 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TPR_19 PF14559.6 EFA78366.1 - 1.7e-08 34.8 10.4 6.5e-05 23.4 1.4 4.3 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA78366.1 - 5.4e-07 30.1 3.0 0.00035 21.2 0.5 3.5 4 1 1 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA78366.1 - 1.3e-06 28.5 9.8 9.9e-06 25.7 7.7 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFA78366.1 - 0.00014 22.1 10.4 0.0041 17.4 1.4 3.2 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78366.1 - 0.00036 20.4 15.1 0.078 13.1 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78366.1 - 0.00067 20.3 6.1 0.21 12.5 0.1 4.1 3 1 2 5 5 4 1 Tetratricopeptide repeat TRI12 PF06609.13 EFA78366.1 - 0.001 17.6 0.3 0.0018 16.8 0.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EFA78366.1 - 0.0017 17.7 0.7 0.0042 16.4 0.7 1.6 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB TPR_15 PF13429.6 EFA78366.1 - 0.0036 16.5 3.5 0.1 11.8 0.5 3.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA78366.1 - 0.0058 16.4 11.8 0.34 10.8 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat MFS_1_like PF12832.7 EFA78366.1 - 0.0071 15.2 0.2 0.0071 15.2 0.2 2.9 2 1 1 3 3 3 1 MFS_1 like family TPR_8 PF13181.6 EFA78366.1 - 0.041 14.1 17.8 0.13 12.5 3.6 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat UNC-93 PF05978.16 EFA78366.1 - 0.16 11.7 3.0 0.23 11.1 1.3 2.2 1 1 0 1 1 1 0 Ion channel regulatory protein UNC-93 TPR_6 PF13174.6 EFA78366.1 - 0.18 12.5 9.1 0.68 10.7 0.4 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78366.1 - 0.2 11.4 7.9 0.81 9.4 1.5 3.4 4 0 0 4 4 3 0 TPR repeat TPR_20 PF14561.6 EFA78366.1 - 0.24 11.8 1.6 30 5.1 0.3 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat YfiO PF13525.6 EFA78366.1 - 0.26 11.0 5.4 0.69 9.6 5.4 1.6 1 0 0 1 1 1 0 Outer membrane lipoprotein FtsH_ext PF06480.15 EFA78366.1 - 0.29 11.5 2.3 4.9 7.6 0.0 3.6 3 0 0 3 3 3 0 FtsH Extracellular TB2_DP1_HVA22 PF03134.19 EFA78366.1 - 2.3 8.2 7.2 0.15 12.0 0.1 2.6 3 0 0 3 3 2 0 TB2/DP1, HVA22 family Ras PF00071.22 EFA78367.1 - 1.1e-52 177.9 0.0 2.3e-52 176.9 0.0 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA78367.1 - 3.5e-20 72.4 1.2 8.4e-20 71.2 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78367.1 - 3e-07 30.1 0.1 5.5e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA78367.1 - 0.00042 19.9 3.0 0.00099 18.7 1.4 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain baeRF_family3 PF18845.1 EFA78367.1 - 0.041 14.2 0.1 0.094 13.0 0.0 1.5 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 LysM PF01476.20 EFA78368.1 - 1.6 8.9 5.7 3.2 7.9 0.1 2.9 3 0 0 3 3 3 0 LysM domain PsbN PF02468.15 EFA78369.1 - 0.34 10.8 1.6 0.78 9.6 1.6 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) Acyl_transf_3 PF01757.22 EFA78370.1 - 4.7e-14 52.2 41.4 1.2e-07 31.2 3.0 2.5 2 1 1 3 3 3 2 Acyltransferase family Acyl_transf_3 PF01757.22 EFA78371.1 - 3.5e-25 88.8 50.5 3.5e-25 88.8 50.5 1.6 2 0 0 2 2 2 1 Acyltransferase family PI3Ka PF00613.20 EFA78372.1 - 1.9e-58 196.9 2.6 4e-58 195.9 2.6 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA78372.1 - 4.9e-50 170.7 0.4 4.9e-50 170.7 0.4 3.1 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EFA78372.1 - 2.9e-17 62.9 0.0 1e-16 61.1 0.0 2.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 EFA78372.1 - 7.4e-09 35.7 6.7 1.5e-08 34.8 0.1 3.5 4 0 0 4 4 4 1 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 EFA78372.1 - 0.00018 20.9 0.0 0.00044 19.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) S10_plectin PF03501.15 EFA78373.1 - 1.1e-30 105.5 0.1 1.4e-30 105.2 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Amino_oxidase PF01593.24 EFA78374.1 - 2.6e-38 132.5 0.0 3e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA78374.1 - 4e-08 33.4 0.2 1.9e-07 31.2 0.2 2.2 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Prenylcys_lyase PF07156.14 EFA78374.1 - 0.0042 16.2 0.1 0.01 15.0 0.0 1.6 2 0 0 2 2 2 1 Prenylcysteine lyase DAO PF01266.24 EFA78374.1 - 0.0079 15.8 0.4 0.062 12.9 0.4 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFA78374.1 - 0.044 13.8 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Nucleopor_Nup85 PF07575.13 EFA78375.1 - 1e-31 110.2 6.8 1e-31 110.2 6.8 3.0 2 1 1 3 3 3 3 Nup85 Nucleoporin HATPase_c_5 PF14501.6 EFA78376.1 - 0.039 13.8 0.2 0.054 13.4 0.2 1.2 1 0 0 1 1 1 0 GHKL domain ALO PF04030.14 EFA78376.1 - 0.072 12.9 0.2 0.081 12.7 0.2 1.0 1 0 0 1 1 1 0 D-arabinono-1,4-lactone oxidase gerPA PF10676.9 EFA78376.1 - 8.3 6.7 9.9 10 6.4 7.2 2.0 1 1 1 2 2 2 0 Spore germination protein gerPA/gerPF ESCRT-II PF05871.12 EFA78377.1 - 3.3e-48 163.5 3.9 4.7e-48 163.0 3.9 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit Arf PF00025.21 EFA78379.1 - 5.1e-19 68.4 0.2 6.5e-19 68.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFA78379.1 - 3.8e-07 29.7 0.5 1.6e-06 27.7 0.5 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA78379.1 - 8e-05 22.3 0.9 0.0005 19.7 0.9 2.0 1 1 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EFA78379.1 - 0.00017 21.2 0.1 0.00096 18.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA78379.1 - 0.00059 19.3 0.8 0.00096 18.6 0.1 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA78379.1 - 0.00078 19.5 0.1 0.0026 17.8 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFA78379.1 - 0.0022 18.2 1.2 0.0097 16.1 0.6 2.3 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EFA78379.1 - 0.0045 16.7 0.1 0.012 15.3 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFA78379.1 - 0.0082 16.1 0.7 0.051 13.5 0.1 2.3 2 1 0 2 2 2 1 RsgA GTPase cobW PF02492.19 EFA78379.1 - 0.031 13.9 1.8 4.3 6.9 0.3 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF4279 PF14106.6 EFA78379.1 - 0.036 14.3 0.8 5.9 7.1 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4279) AAA_23 PF13476.6 EFA78379.1 - 0.044 14.3 0.9 0.071 13.6 0.9 1.5 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFA78379.1 - 0.047 13.4 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 EFA78379.1 - 0.056 12.5 0.1 0.12 11.4 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 EFA78379.1 - 0.062 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1_Xtn PF16897.5 EFA78379.1 - 0.064 13.3 0.4 0.35 10.9 0.4 2.0 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_16 PF13191.6 EFA78379.1 - 0.083 13.3 0.0 0.3 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Aldedh PF00171.22 EFA78380.1 - 3.1e-182 606.2 0.0 4.1e-182 605.8 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family HSP70 PF00012.20 EFA78380.1 - 3.4e-134 448.3 1.2 2.1e-118 396.1 0.2 2.1 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EFA78380.1 - 6.5e-09 35.0 0.2 4e-08 32.4 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Med3 PF11593.8 EFA78381.1 - 2.7 7.1 6.5 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal TPR_1 PF00515.28 EFA78382.1 - 2.6e-14 52.3 0.4 7.6e-05 22.4 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78382.1 - 1.4e-11 43.5 0.1 0.0012 18.7 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78382.1 - 5.1e-07 29.4 0.0 0.83 10.0 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA78382.1 - 1.3e-05 25.6 0.2 0.00032 21.2 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA78382.1 - 0.00012 22.6 0.0 0.00055 20.5 0.0 2.1 3 0 0 3 3 1 1 Tetratricopeptide repeat OspE PF02471.17 EFA78382.1 - 0.0003 21.0 1.9 0.00052 20.2 0.7 2.1 1 1 0 1 1 1 1 Borrelia outer surface protein E TPR_14 PF13428.6 EFA78382.1 - 0.00031 21.3 0.0 0.69 10.9 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA78382.1 - 0.00031 21.2 0.0 1.9 9.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78382.1 - 0.00066 19.3 0.0 0.016 14.9 0.0 3.0 2 1 1 3 3 3 1 TPR repeat TPR_7 PF13176.6 EFA78382.1 - 0.0011 18.9 0.0 0.033 14.2 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA78382.1 - 0.004 17.4 0.1 0.062 13.5 0.1 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFA78382.1 - 0.0044 17.1 0.0 0.0088 16.2 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78382.1 - 0.0046 17.2 0.0 0.096 13.0 0.1 2.9 3 1 0 3 3 2 1 Tetratricopeptide repeat RPN7 PF10602.9 EFA78382.1 - 0.0094 15.7 1.8 0.076 12.7 1.8 2.6 1 1 0 1 1 1 1 26S proteasome subunit RPN7 TPR_17 PF13431.6 EFA78382.1 - 0.019 15.3 0.0 6.1 7.5 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA78382.1 - 0.028 14.5 0.3 1.1 9.4 0.0 2.9 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EFA78382.1 - 0.12 12.3 0.1 14 5.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Aida_N PF08910.10 EFA78382.1 - 0.37 11.2 3.4 1.1 9.7 0.1 3.1 3 1 1 4 4 4 0 Aida N-terminus MIT PF04212.18 EFA78382.1 - 0.9 9.6 4.6 1.6 8.9 0.2 3.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Ras PF00071.22 EFA78383.1 - 8.4e-55 184.8 0.0 1e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA78383.1 - 5.2e-22 78.3 0.0 9.3e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78383.1 - 7.1e-10 38.6 0.0 9e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA78383.1 - 0.00044 19.9 0.0 0.0018 17.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Asn_synthase PF00733.21 EFA78384.1 - 3.6e-16 59.8 0.9 3.8e-07 30.1 0.5 3.2 2 1 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EFA78384.1 - 2e-08 34.2 0.0 4.8e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFA78384.1 - 1.3e-05 25.4 0.0 3.8e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain ATP_bind_3 PF01171.20 EFA78384.1 - 0.018 14.8 3.6 0.25 11.1 0.0 2.9 3 0 0 3 3 3 0 PP-loop family QueC PF06508.13 EFA78384.1 - 0.16 11.4 0.0 0.38 10.2 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC DNA_pol_A PF00476.20 EFA78385.1 - 3.6e-97 325.8 1.5 5.2e-97 325.3 1.5 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 EFA78385.1 - 0.0012 18.6 0.1 0.0034 17.1 0.1 1.7 1 0 0 1 1 1 1 3'-5' exonuclease VPS9 PF02204.18 EFA78386.1 - 2.9e-13 49.9 1.3 1e-12 48.2 0.0 2.7 2 1 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain zf-CCCH PF00642.24 EFA78387.1 - 1.1e-09 38.0 1.6 1.7e-09 37.3 1.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA78387.1 - 8.5e-07 28.8 3.3 1.5e-06 28.1 3.3 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFA78387.1 - 8e-06 25.5 1.0 1.3e-05 24.9 1.0 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EFA78387.1 - 0.19 12.3 1.6 0.35 11.4 1.6 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Eapp_C PF10238.9 EFA78388.1 - 2.6e-47 160.7 17.0 5.3e-47 159.6 17.0 1.5 1 0 0 1 1 1 1 E2F-associated phosphoprotein TPR_1 PF00515.28 EFA78389.1 - 3.1e-31 105.9 20.3 1.6e-07 30.8 0.1 9.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78389.1 - 2.5e-28 95.9 27.0 1.4e-05 24.8 0.1 10.0 10 0 0 10 10 9 7 Tetratricopeptide repeat SpoU_methylase PF00588.19 EFA78389.1 - 5.6e-26 91.4 0.1 7.9e-25 87.7 0.1 2.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family TPR_8 PF13181.6 EFA78389.1 - 1.6e-24 84.0 27.4 0.00036 20.5 0.1 9.2 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78389.1 - 3.2e-22 78.6 14.3 0.00097 19.4 0.0 7.8 6 1 1 7 7 7 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA78389.1 - 2.6e-19 69.2 34.0 3.4e-07 30.4 1.2 7.3 4 2 4 8 8 8 7 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFA78389.1 - 8.3e-16 58.4 2.5 2.8e-06 27.9 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA78389.1 - 7.3e-15 55.2 4.0 0.032 14.7 0.0 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFA78389.1 - 1.3e-14 53.4 11.9 0.017 15.5 0.1 8.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78389.1 - 8.5e-12 44.6 12.7 2.9e-05 23.7 0.4 6.8 5 1 1 6 6 6 2 TPR repeat TPR_14 PF13428.6 EFA78389.1 - 1.7e-11 43.9 2.2 1.4 9.9 0.0 7.9 4 2 4 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA78389.1 - 2.8e-08 33.5 4.2 0.077 12.4 0.0 5.0 2 2 3 5 5 5 2 MalT-like TPR region TPR_9 PF13371.6 EFA78389.1 - 3.4e-07 30.3 0.0 0.059 13.5 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA78389.1 - 5.3e-07 29.9 16.4 12 6.7 0.1 9.0 9 0 0 9 9 9 0 Tetratricopeptide repeat NARP1 PF12569.8 EFA78389.1 - 0.0004 19.4 0.2 0.0004 19.4 0.2 4.2 5 0 0 5 5 5 1 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 EFA78389.1 - 0.0013 18.5 8.0 6.4 6.8 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA78389.1 - 0.036 14.1 19.7 8.5 6.7 0.0 7.8 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFA78389.1 - 0.066 13.9 0.0 0.58 10.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat PT PF04886.12 EFA78390.1 - 3.3e-07 29.7 229.5 0.00094 18.7 30.7 16.3 4 3 2 6 6 6 3 PT repeat CBM49 PF09478.10 EFA78390.1 - 0.00012 22.4 0.7 0.12 12.7 0.1 2.4 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 Dus PF01207.17 EFA78391.1 - 4.4e-54 183.7 0.0 1e-53 182.5 0.0 1.6 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EFA78391.1 - 9.3e-09 35.0 8.8 3.3e-06 26.9 0.2 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFA78391.1 - 1.4e-07 31.1 6.0 5.5e-06 26.1 0.5 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFA78391.1 - 1.6e-05 24.8 11.4 0.00017 21.5 1.0 2.5 2 0 0 2 2 2 2 Zinc finger domain Lustrin_cystein PF14625.6 EFA78391.1 - 0.1 13.0 0.6 0.47 10.9 0.2 2.4 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain zf-CCCH_2 PF14608.6 EFA78391.1 - 0.13 12.8 4.9 2.2 8.8 0.6 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF3439 PF11921.8 EFA78391.1 - 0.57 10.1 18.4 4.6 7.2 9.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) VRR_NUC PF08774.11 EFA78392.1 - 1.3e-16 60.6 0.0 3.6e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 VRR-NUC domain Prot_ATP_ID_OB PF16450.5 EFA78392.1 - 0.071 13.1 1.5 5 7.2 1.1 2.5 2 0 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain RasGEF PF00617.19 EFA78393.1 - 4.4e-23 82.4 1.1 1.2e-22 81.0 1.1 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA78393.1 - 3.5e-20 72.2 2.0 3.5e-20 72.2 2.0 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif Cytochrom_B562 PF07361.11 EFA78393.1 - 2.5 8.8 4.4 3.1 8.5 1.9 2.5 3 0 0 3 3 3 0 Cytochrome b562 Glyco_hydr_30_2 PF14587.6 EFA78395.1 - 1.6e-12 47.7 5.8 1.6e-12 47.7 5.8 1.8 2 0 0 2 2 2 1 O-Glycosyl hydrolase family 30 Glyco_hydro_59 PF02057.15 EFA78395.1 - 1.1e-07 31.4 1.0 1.8e-07 30.7 0.6 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 59 Nse4_C PF08743.10 EFA78396.1 - 1.4e-20 73.3 0.1 1.4e-20 73.3 0.1 2.5 2 1 1 3 3 3 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EFA78396.1 - 2.8e-08 33.8 0.0 9e-08 32.1 0.0 1.9 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE LIME1 PF15332.6 EFA78396.1 - 0.036 13.7 0.2 0.089 12.4 0.2 1.7 1 0 0 1 1 1 0 Lck-interacting transmembrane adapter 1 VGCC_beta4Aa_N PF12052.8 EFA78396.1 - 2 8.6 8.1 0.25 11.5 1.4 2.5 2 0 0 2 2 2 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal DUF4539 PF15072.6 EFA78397.1 - 5.4e-24 84.0 0.1 1e-23 83.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) Tom7 PF08038.12 EFA78398.1 - 3.7e-05 23.3 0.2 4.7e-05 22.9 0.2 1.2 1 0 0 1 1 1 1 TOM7 family Innexin PF00876.18 EFA78398.1 - 0.063 12.6 0.0 0.063 12.6 0.0 1.0 1 0 0 1 1 1 0 Innexin TPR_2 PF07719.17 EFA78399.1 - 3.2e-08 33.1 8.2 0.014 15.4 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA78399.1 - 2.1e-06 27.9 6.3 0.019 15.2 0.0 4.1 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFA78399.1 - 4.9e-06 26.3 4.9 0.36 11.2 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA78399.1 - 1.2e-05 25.6 1.7 0.14 12.9 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA78399.1 - 5.5e-05 22.8 7.1 0.0082 15.9 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA78399.1 - 9.5e-05 22.8 3.7 0.099 13.2 0.1 4.8 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78399.1 - 0.0008 20.0 4.8 11 7.2 0.1 5.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFA78399.1 - 0.0013 18.8 0.3 0.086 13.0 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78399.1 - 0.0014 18.9 7.7 10 6.5 0.3 5.8 4 2 1 5 5 5 1 Tetratricopeptide repeat ANAPC5 PF12862.7 EFA78399.1 - 0.0082 16.2 1.3 0.49 10.5 0.2 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 EFA78399.1 - 0.023 14.5 0.3 12 6.0 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFA78399.1 - 0.066 12.9 0.0 1.3 8.7 0.0 2.6 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) RE_SinI PF09570.10 EFA78399.1 - 0.09 12.0 0.0 8.5 5.5 0.0 2.4 2 0 0 2 2 2 0 SinI restriction endonuclease TPR_11 PF13414.6 EFA78399.1 - 0.31 10.8 6.0 3.2 7.5 0.2 4.0 4 0 0 4 4 4 0 TPR repeat DREV PF05219.12 EFA78400.1 - 5.9e-53 179.6 0.1 2.4e-44 151.5 0.0 2.3 2 0 0 2 2 2 2 DREV methyltransferase Methyltransf_11 PF08241.12 EFA78400.1 - 1.6e-12 47.9 0.0 3.8e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA78400.1 - 1.5e-11 44.9 2.2 3.6e-11 43.7 0.0 2.8 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA78400.1 - 2.8e-10 40.3 0.0 5e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA78400.1 - 1.5e-09 38.4 0.0 3.6e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA78400.1 - 4.4e-05 23.3 0.3 0.00048 19.9 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.20 EFA78400.1 - 0.00049 19.3 0.0 0.0012 18.0 0.0 1.5 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Glyc_hyd_38C_2 PF18230.1 EFA78400.1 - 0.0054 16.8 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal sub-domain NNMT_PNMT_TEMT PF01234.17 EFA78400.1 - 0.083 12.1 0.0 0.17 11.0 0.0 1.5 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_9 PF08003.11 EFA78400.1 - 0.084 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.19 EFA78400.1 - 0.2 11.4 0.1 0.61 9.8 0.1 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PPR_2 PF13041.6 EFA78401.1 - 1.2e-18 67.1 10.8 1.1e-12 47.9 0.1 5.4 5 1 1 6 6 6 3 PPR repeat family PPR_3 PF13812.6 EFA78401.1 - 2.9e-11 43.3 2.2 4.7e-07 29.8 0.1 3.7 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.20 EFA78401.1 - 3.1e-05 23.9 2.6 0.0008 19.5 0.1 3.9 3 0 0 3 3 3 1 PPR repeat PPR_long PF17177.4 EFA78401.1 - 9.8e-05 21.8 1.7 0.091 12.1 0.0 2.7 3 0 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFA78401.1 - 0.06 13.0 4.7 2.6 7.8 0.0 4.4 5 0 0 5 5 5 0 PPR repeat Ank_2 PF12796.7 EFA78402.1 - 1e-14 54.9 3.4 0.0013 19.3 0.0 7.1 3 2 4 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78402.1 - 1.6e-13 50.8 1.8 0.85 10.3 0.0 7.9 7 2 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78402.1 - 3.3e-12 45.5 3.3 2.9 8.7 0.0 9.8 11 1 1 12 12 12 3 Ankyrin repeat Ank_5 PF13857.6 EFA78402.1 - 2e-10 40.7 0.9 6.1 7.3 0.0 7.9 6 1 1 7 7 7 2 Ankyrin repeats (many copies) baeRF_family7 PF18849.1 EFA78402.1 - 0.056 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 CorA PF01544.18 EFA78403.1 - 0.0076 15.6 0.3 0.022 14.1 0.1 1.8 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Menin PF05053.13 EFA78403.1 - 0.22 9.8 6.3 0.29 9.5 6.3 1.1 1 0 0 1 1 1 0 Menin NST1 PF13945.6 EFA78403.1 - 3.4 7.7 11.3 6.8 6.8 11.3 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator PAP2 PF01569.21 EFA78404.1 - 8.4e-21 74.2 5.0 8.4e-21 74.2 5.0 1.5 2 0 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EFA78404.1 - 0.0093 16.1 1.9 0.52 10.4 0.2 2.3 1 1 1 2 2 2 2 Divergent PAP2 family Spo7 PF03907.13 EFA78404.1 - 0.068 12.6 3.9 0.7 9.3 2.3 2.3 1 1 1 2 2 2 0 Spo7-like protein UPF0542 PF15086.6 EFA78404.1 - 0.13 12.2 2.6 0.24 11.3 0.1 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 PAP2_3 PF14378.6 EFA78404.1 - 0.69 9.6 11.8 1.5 8.5 10.9 1.8 1 1 1 2 2 2 0 PAP2 superfamily DUF4131 PF13567.6 EFA78404.1 - 0.87 9.2 5.9 2.2 7.9 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Herpes_US12 PF05363.12 EFA78405.1 - 1.3 9.8 3.2 21 5.9 0.5 3.3 2 0 0 2 2 2 0 Herpesvirus US12 family zinc_ribbon_5 PF13719.6 EFA78406.1 - 0.0027 17.4 0.7 0.019 14.7 0.2 2.1 2 0 0 2 2 2 1 zinc-ribbon domain TTKRSYEDQ PF10212.9 EFA78406.1 - 0.0041 16.2 3.9 0.0051 15.9 3.9 1.1 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DUF3251 PF11622.8 EFA78406.1 - 0.032 13.9 0.2 0.043 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) KLRAQ PF10205.9 EFA78407.1 - 1.8e-24 85.9 11.5 1.8e-24 85.9 11.5 5.0 3 1 1 4 4 4 1 Predicted coiled-coil domain-containing protein EzrA PF06160.12 EFA78407.1 - 0.0024 16.1 29.3 0.0024 16.1 29.3 3.7 3 1 0 3 3 3 2 Septation ring formation regulator, EzrA PDCD2_C PF04194.13 EFA78408.1 - 3.1e-33 115.3 2.2 3.1e-33 115.3 2.2 2.9 2 1 2 4 4 4 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 EFA78408.1 - 3.5e-07 30.2 13.6 3.5e-07 30.2 13.6 2.9 5 0 0 5 5 5 1 MYND finger Sporozoite_P67 PF05642.11 EFA78408.1 - 1.1 7.2 3.5 1.6 6.8 3.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tctex-1 PF03645.13 EFA78409.1 - 6.9e-32 109.8 1.3 8.1e-32 109.5 1.3 1.1 1 0 0 1 1 1 1 Tctex-1 family DUF2368 PF10166.9 EFA78411.1 - 6.9e-17 61.3 0.2 7.4e-17 61.2 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) MFS_1 PF07690.16 EFA78412.1 - 1.1e-23 83.8 36.1 6.1e-18 64.9 1.7 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4171 PF13775.6 EFA78412.1 - 0.18 12.3 1.4 0.28 11.6 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4171) PI3K_1B_p101 PF10486.9 EFA78412.1 - 3.6 5.2 5.0 4.9 4.8 5.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TFIIIC_sub6 PF10419.9 EFA78414.1 - 2.1e-13 49.9 5.0 5.9e-13 48.5 5.0 2.1 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain PNISR PF15996.5 EFA78414.1 - 2.3 8.4 32.1 0.34 11.2 19.2 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR HSP20 PF00011.21 EFA78416.1 - 5.7e-19 68.2 0.0 2.1e-18 66.3 0.0 2.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA78416.1 - 6.9e-10 38.3 0.0 1.5e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA zf-C2H2 PF00096.26 EFA78417.1 - 4.5e-18 64.6 26.6 6.6e-05 23.1 2.0 5.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFA78417.1 - 2.9e-13 49.6 35.7 1e-06 28.9 2.4 6.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFA78417.1 - 3.8e-08 33.5 34.7 0.0043 17.8 0.7 6.0 6 0 0 6 6 6 4 C2H2-type zinc finger LisH PF08513.11 EFA78417.1 - 0.00012 21.9 0.1 0.00029 20.7 0.1 1.7 1 0 0 1 1 1 1 LisH Mucin PF01456.17 EFA78417.1 - 0.037 14.0 15.1 0.63 10.0 3.3 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3439 PF11921.8 EFA78417.1 - 0.061 13.3 11.0 0.46 10.5 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) GpcrRhopsn4 PF10192.9 EFA78419.1 - 1.5e-72 244.1 22.1 2.4e-72 243.5 22.1 1.3 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 EFA78419.1 - 9.2e-07 28.4 16.6 1.8e-06 27.4 16.6 1.4 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF2427 PF10348.9 EFA78419.1 - 0.15 11.8 5.7 0.26 11.1 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) Cation_ATPase_C PF00689.21 EFA78420.1 - 5.2e-37 127.3 10.6 5.2e-37 127.3 10.6 3.2 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFA78420.1 - 3.4e-34 118.0 0.0 3.4e-34 118.0 0.0 3.6 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EFA78420.1 - 1.4e-14 54.9 4.3 1.8e-13 51.3 4.3 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA78420.1 - 8.8e-10 38.1 0.0 2.5e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFA78420.1 - 3.7e-08 33.4 0.0 6.9e-07 29.3 0.0 2.7 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFA78420.1 - 1.7e-07 31.2 2.7 2.8e-05 24.0 1.1 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF3372 PF11852.8 EFA78420.1 - 0.093 12.2 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) TrbC PF04956.13 EFA78420.1 - 0.18 12.0 0.1 0.18 12.0 0.1 3.0 3 0 0 3 3 3 0 TrbC/VIRB2 family Phage_holin_2_3 PF16080.5 EFA78420.1 - 0.38 10.5 2.8 0.51 10.1 0.2 2.3 2 0 0 2 2 2 0 Bacteriophage holin family HP1 NOT2_3_5 PF04153.18 EFA78422.1 - 2.4e-28 98.8 0.9 2.4e-28 98.8 0.9 3.7 3 2 0 3 3 3 1 NOT2 / NOT3 / NOT5 family EPL1 PF10513.9 EFA78422.1 - 0.0068 16.8 3.1 0.0068 16.8 3.1 3.1 2 1 0 2 2 2 1 Enhancer of polycomb-like Ank_2 PF12796.7 EFA78424.1 - 2.4e-09 37.6 0.3 0.00011 22.7 0.1 3.5 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78424.1 - 1e-06 28.9 0.2 0.82 10.1 0.0 4.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA78424.1 - 3e-06 27.7 1.5 0.062 13.9 0.1 4.4 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78424.1 - 0.012 16.1 0.4 64 4.6 0.0 5.0 5 0 0 5 5 5 0 Ankyrin repeat Ank_2 PF12796.7 EFA78425.1 - 1.4e-18 67.2 0.5 2e-08 34.7 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78425.1 - 7.1e-13 48.8 0.3 0.0018 18.8 0.0 4.3 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78425.1 - 2.6e-12 46.7 0.9 0.0043 17.3 0.0 5.2 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78425.1 - 4.6e-09 35.8 0.4 0.68 10.7 0.1 5.6 6 0 0 6 6 6 2 Ankyrin repeat DUF5049 PF16468.5 EFA78425.1 - 0.0066 16.3 2.1 2.5 8.0 0.0 4.7 4 2 2 6 6 6 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA78425.1 - 0.017 15.6 1.1 27 5.4 0.1 4.9 6 0 0 6 6 6 0 Ankyrin repeat Peptidase_C1 PF00112.23 EFA78427.1 - 3.9e-79 265.8 5.7 4.9e-79 265.4 5.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA78427.1 - 4.7e-10 39.7 2.2 9.4e-10 38.8 2.2 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA78427.1 - 0.0058 15.5 4.6 0.13 11.0 0.5 2.4 2 1 0 2 2 2 2 Peptidase C1-like family Aa_trans PF01490.18 EFA78429.1 - 0.0026 16.5 13.1 0.14 10.8 0.1 3.0 2 1 2 4 4 4 3 Transmembrane amino acid transporter protein SAE2 PF08573.10 EFA78432.1 - 7e-05 23.9 9.7 0.0009 20.3 2.4 5.3 4 2 1 5 5 5 2 DNA repair protein endonuclease SAE2/CtIP C-terminus Inhibitor_I53 PF11714.8 EFA78432.1 - 0.93 9.7 3.8 1.6 9.0 2.3 2.2 2 0 0 2 2 2 0 Thrombin inhibitor Madanin bZIP_1 PF00170.21 EFA78433.1 - 1.4e-07 31.5 2.2 1.4e-07 31.5 2.2 3.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFA78433.1 - 3.4e-06 27.0 4.0 3.4e-06 27.0 4.0 5.4 6 0 0 6 6 6 1 Basic region leucine zipper SSP160 PF06933.11 EFA78433.1 - 9.5 4.3 11.5 14 3.7 11.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 VWA PF00092.28 EFA78435.1 - 3.8e-06 27.3 1.2 1.7e-05 25.2 0.0 2.7 3 1 0 3 3 3 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA78435.1 - 0.0017 19.0 0.4 0.021 15.5 0.0 3.1 2 1 1 3 3 3 1 von Willebrand factor type A domain NIF PF03031.18 EFA78437.1 - 1.8e-18 66.8 3.8 3.7e-18 65.8 3.8 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EFA78437.1 - 9.3e-12 45.2 0.1 4e-11 43.1 0.1 2.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFA78437.1 - 4.5e-08 32.9 0.4 5.8e-07 29.4 0.1 2.4 2 0 0 2 2 2 1 twin BRCT domain BRCT_2 PF16589.5 EFA78437.1 - 0.0013 19.1 1.9 0.0067 16.8 0.1 3.0 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Pkinase_Tyr PF07714.17 EFA78438.1 - 2.5e-57 194.1 1.4 3.4e-57 193.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA78438.1 - 9.1e-51 172.7 0.0 9.1e-51 172.7 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain RGS PF00615.19 EFA78438.1 - 1.7e-20 73.5 5.4 1.7e-20 73.5 5.4 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain RIO1 PF01163.22 EFA78438.1 - 0.00047 19.8 3.1 0.011 15.3 0.2 3.1 3 0 0 3 3 3 1 RIO1 family APH PF01636.23 EFA78438.1 - 0.00068 19.6 1.0 0.0048 16.8 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Spt20 PF12090.8 EFA78438.1 - 0.0033 17.1 25.1 0.0033 17.1 25.1 4.5 3 1 1 4 4 4 1 Spt20 family Kdo PF06293.14 EFA78438.1 - 0.0066 15.8 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFA78438.1 - 0.0096 15.3 0.0 0.0096 15.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFA78438.1 - 0.0097 14.7 0.5 0.0097 14.7 0.5 2.9 2 1 0 3 3 3 1 Fungal protein kinase DNA_pol_E_B PF04042.16 EFA78439.1 - 1.5e-29 102.9 1.9 1.5e-29 102.9 1.9 1.9 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DUF4680 PF15730.5 EFA78439.1 - 0.043 14.1 7.5 2.5 8.4 6.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) DUF4615 PF15393.6 EFA78439.1 - 1.1 9.9 6.5 2.7 8.6 6.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4615) DUF3439 PF11921.8 EFA78439.1 - 1.5 8.8 24.9 1.7 8.6 2.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) WD40 PF00400.32 EFA78440.1 - 1.1e-23 83.0 19.5 9.6e-07 29.4 0.3 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78440.1 - 6.2e-15 55.3 0.0 0.0014 18.9 0.0 5.5 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA78440.1 - 0.00076 18.5 1.8 0.68 8.8 0.0 3.6 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFA78440.1 - 0.013 15.4 5.3 1 9.4 1.1 3.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DDHD PF02862.17 EFA78440.1 - 0.034 14.3 15.6 1.3 9.1 2.6 3.2 3 0 0 3 3 3 0 DDHD domain Mucin PF01456.17 EFA78440.1 - 1.5 8.8 43.3 0.12 12.4 10.1 3.2 3 0 0 3 3 3 0 Mucin-like glycoprotein DUF2052 PF09747.9 EFA78440.1 - 2.8 8.0 19.1 1.4 9.0 10.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Afi1 PF07792.12 EFA78441.1 - 1.8e-21 77.0 9.9 4.9e-19 69.1 0.0 3.3 3 0 0 3 3 3 2 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 EFA78441.1 - 0.0013 17.5 0.0 0.012 14.3 0.0 2.5 2 0 0 2 2 2 1 Transport protein Avl9 Mistic PF11458.8 EFA78441.1 - 0.15 12.1 1.0 0.84 9.6 0.0 2.8 3 0 0 3 3 3 0 Membrane-integrating protein Mistic Macoilin PF09726.9 EFA78441.1 - 0.4 9.2 23.5 0.75 8.3 9.0 2.3 2 0 0 2 2 2 0 Macoilin family Glycolytic PF00274.19 EFA78442.1 - 3.2e-167 555.6 0.0 3.6e-167 555.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Glyco_hydro_38N PF01074.22 EFA78443.1 - 1e-74 251.5 1.1 1.5e-74 251.0 1.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFA78443.1 - 1.7e-16 60.9 0.2 3.5e-16 59.9 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFA78443.1 - 2.1e-14 53.4 0.0 4.3e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain YfiO PF13525.6 EFA78443.1 - 0.0034 17.1 1.3 0.0061 16.3 1.3 1.3 1 0 0 1 1 1 1 Outer membrane lipoprotein AfsA PF03756.13 EFA78443.1 - 0.014 15.4 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 A-factor biosynthesis hotdog domain BCDHK_Adom3 PF10436.9 EFA78443.1 - 0.12 12.2 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF4944 PF16302.5 EFA78444.1 - 0.04 14.0 0.1 0.9 9.6 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4944) Castor_Poll_mid PF06241.12 EFA78445.1 - 0.038 14.0 0.0 0.077 13.0 0.0 1.5 1 0 0 1 1 1 0 Castor and Pollux, part of voltage-gated ion channel Exo_endo_phos PF03372.23 EFA78445.1 - 0.089 12.3 0.0 0.17 11.4 0.0 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family RNase_H2-Ydr279 PF09468.10 EFA78446.1 - 1.3e-07 31.9 1.9 1.7e-07 31.6 0.1 2.2 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EFA78446.1 - 2.9e-05 24.2 0.7 0.00024 21.3 0.1 2.7 2 1 0 2 2 2 1 Ydr279p protein triple barrel domain FAM176 PF14851.6 EFA78446.1 - 2.3 7.9 14.5 2.1 8.0 0.8 2.5 2 0 0 2 2 2 0 FAM176 family COG2 PF06148.11 EFA78448.1 - 3.3e-32 111.4 3.6 3.3e-32 111.4 3.6 3.1 4 0 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 EFA78448.1 - 1.2e-30 106.5 8.6 2.3e-30 105.6 0.0 3.7 3 1 1 4 4 4 1 Domain of unknown function (DUF3510) Mucin PF01456.17 EFA78448.1 - 0.00083 19.4 9.5 0.00083 19.4 9.5 3.2 3 0 0 3 3 3 1 Mucin-like glycoprotein COG5 PF10392.9 EFA78448.1 - 0.0016 18.7 18.4 0.0089 16.2 0.2 4.2 3 0 0 3 3 3 2 Golgi transport complex subunit 5 Vps51 PF08700.11 EFA78448.1 - 0.013 15.6 0.1 0.013 15.6 0.1 4.1 3 2 1 4 4 4 0 Vps51/Vps67 BLI1 PF17324.2 EFA78448.1 - 1.8 9.2 6.3 6.3 7.5 0.0 3.7 4 0 0 4 4 4 0 BLOC-1 interactor 1 DASH_Duo1 PF08651.10 EFA78448.1 - 2.8 7.8 12.5 0.38 10.6 2.6 4.0 3 1 0 3 3 3 0 DASH complex subunit Duo1 DUF866 PF05907.13 EFA78449.1 - 6.7e-34 117.0 6.3 2.6e-33 115.1 6.3 2.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Cyt-b5 PF00173.28 EFA78450.1 - 2.3e-19 69.3 0.0 4.4e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NIF PF03031.18 EFA78450.1 - 9.4e-19 67.7 0.1 2.5e-18 66.3 0.1 1.7 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ETRAMP PF09716.10 EFA78450.1 - 0.15 12.1 4.9 0.95 9.6 2.4 3.0 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) RXT2_N PF08595.11 EFA78450.1 - 0.18 11.9 6.6 0.72 9.9 0.4 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF2796 PF10986.8 EFA78450.1 - 0.72 9.8 13.7 0.094 12.7 6.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) Zip PF02535.22 EFA78450.1 - 1.6 7.9 6.5 4.7 6.3 0.3 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter NOA36 PF06524.12 EFA78450.1 - 3.2 7.0 9.3 2 7.6 0.9 2.2 2 0 0 2 2 2 0 NOA36 protein DUF3591 PF12157.8 EFA78451.1 - 4.4e-151 503.5 2.0 1e-150 502.3 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 EFA78451.1 - 9.5e-16 57.6 0.7 3.9e-15 55.7 0.7 2.0 1 0 0 1 1 1 1 Bromodomain TBP-binding PF09247.11 EFA78451.1 - 0.0016 18.7 2.5 0.0016 18.7 2.5 2.5 2 0 0 2 2 2 1 TATA box-binding protein binding Baculo_ME53 PF06061.11 EFA78452.1 - 0.00033 20.0 0.0 0.00037 19.8 0.0 1.1 1 0 0 1 1 1 1 Baculoviridae ME53 Cofilin_ADF PF00241.20 EFA78452.1 - 0.0026 17.5 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PAC4 PF16093.5 EFA78452.1 - 0.01 16.0 0.5 0.046 13.9 0.5 1.9 1 1 0 1 1 1 0 Proteasome assembly chaperone 4 Mif2_N PF15624.6 EFA78454.1 - 2.8 8.7 18.1 0.035 14.8 6.3 3.3 2 1 1 3 3 3 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Helicase_C PF00271.31 EFA78455.1 - 7.3e-13 48.8 1.6 1.2e-11 45.0 0.0 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain SUV3_C PF12513.8 EFA78455.1 - 7.4e-11 41.8 0.1 1.8e-10 40.6 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 EFA78455.1 - 1.4e-06 28.0 0.0 3.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 PBP1_TM PF14812.6 EFA78455.1 - 0.12 12.8 0.5 0.31 11.5 0.5 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SprA-related PF12118.8 EFA78455.1 - 5.8 6.0 10.6 0.4 9.8 4.6 1.9 2 0 0 2 2 2 0 SprA-related family Ank_2 PF12796.7 EFA78456.1 - 2.9e-21 75.9 10.7 1.1e-07 32.3 1.0 4.6 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78456.1 - 1e-18 67.4 7.9 0.00068 20.1 0.0 7.8 3 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78456.1 - 2.9e-14 52.9 22.8 0.011 16.1 0.2 9.6 5 2 6 11 11 11 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78456.1 - 1.9e-08 33.9 5.3 46 5.1 0.0 9.0 8 2 2 10 10 10 0 Ankyrin repeat Ank PF00023.30 EFA78456.1 - 0.028 14.9 7.3 82 3.9 0.0 6.2 4 2 2 6 6 6 0 Ankyrin repeat AAA PF00004.29 EFA78457.1 - 1.3e-90 300.6 4.7 3.7e-47 160.0 0.0 4.5 4 1 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) Nucleolin_bd PF16725.5 EFA78457.1 - 1.1e-19 69.8 0.6 2.7e-19 68.6 0.6 1.7 1 0 0 1 1 1 1 Nucleolin binding domain AAA_lid_3 PF17862.1 EFA78457.1 - 2.7e-17 62.3 0.5 1.4e-08 34.4 0.3 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EFA78457.1 - 3.1e-15 56.3 0.0 1e-06 28.6 0.0 3.3 4 0 0 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFA78457.1 - 8.6e-15 55.3 1.1 2.6e-07 30.9 0.2 3.0 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFA78457.1 - 4.5e-13 49.9 0.4 0.0022 18.4 0.0 4.6 2 2 2 4 4 4 2 AAA ATPase domain AAA_33 PF13671.6 EFA78457.1 - 5.5e-10 39.6 2.9 0.00097 19.3 0.4 4.0 3 1 0 3 3 3 2 AAA domain AAA_22 PF13401.6 EFA78457.1 - 2.2e-09 37.7 0.4 0.02 15.2 0.1 5.2 3 2 1 4 4 3 2 AAA domain TIP49 PF06068.13 EFA78457.1 - 8.1e-09 35.1 0.1 0.00065 19.0 0.0 2.7 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_5 PF07728.14 EFA78457.1 - 1.3e-08 35.0 1.8 0.0037 17.3 0.0 4.3 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFA78457.1 - 3.1e-08 33.7 0.0 0.018 15.0 0.0 3.4 3 1 0 3 3 2 2 AAA domain Vps4_C PF09336.10 EFA78457.1 - 4.7e-08 32.9 5.6 1.3e-05 25.0 0.3 3.0 3 0 0 3 3 2 2 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 EFA78457.1 - 5.2e-08 33.2 0.0 0.0089 16.4 0.0 3.4 2 1 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 EFA78457.1 - 1.6e-07 30.9 0.5 0.012 15.0 0.0 2.9 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFA78457.1 - 4e-07 29.9 0.2 0.025 14.3 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 EFA78457.1 - 3.4e-06 27.4 0.0 0.12 12.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EFA78457.1 - 5e-06 26.5 2.7 0.15 12.0 0.0 4.2 4 1 0 5 5 4 2 NACHT domain TsaE PF02367.17 EFA78457.1 - 6.8e-06 26.1 0.0 0.12 12.4 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EFA78457.1 - 1.4e-05 24.9 0.0 0.25 11.0 0.0 3.5 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 EFA78457.1 - 1.4e-05 24.7 1.5 0.12 11.9 0.0 3.8 2 1 0 3 3 3 2 P-loop containing dynein motor region AAA_18 PF13238.6 EFA78457.1 - 3.5e-05 24.3 6.8 0.12 12.9 0.0 4.1 3 1 0 3 3 2 2 AAA domain AAA_25 PF13481.6 EFA78457.1 - 7.7e-05 22.4 7.1 1.9 8.0 0.0 4.9 5 1 0 6 6 6 1 AAA domain Zeta_toxin PF06414.12 EFA78457.1 - 0.00021 20.6 4.9 0.031 13.6 0.0 3.3 3 0 0 3 3 3 2 Zeta toxin AAA_3 PF07726.11 EFA78457.1 - 0.00023 21.0 0.0 0.55 10.1 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFA78457.1 - 0.00036 21.0 12.6 0.077 13.5 0.0 4.0 3 1 0 3 3 3 1 ABC transporter AAA_24 PF13479.6 EFA78457.1 - 0.00042 20.1 0.0 1.3 8.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EFA78457.1 - 0.00059 19.4 0.3 1.4 8.3 0.0 2.8 2 0 0 2 2 2 2 PhoH-like protein Rad17 PF03215.15 EFA78457.1 - 0.00078 19.4 0.1 0.31 10.9 0.0 2.9 2 1 0 2 2 2 1 Rad17 P-loop domain NB-ARC PF00931.22 EFA78457.1 - 0.001 18.3 1.1 0.72 9.0 0.0 3.1 3 0 0 3 3 2 1 NB-ARC domain AAA_17 PF13207.6 EFA78457.1 - 0.0013 19.2 5.8 0.62 10.5 0.0 3.8 5 0 0 5 5 2 2 AAA domain Parvo_NS1 PF01057.17 EFA78457.1 - 0.0014 17.8 4.6 0.39 9.8 0.0 3.0 3 0 0 3 3 2 2 Parvovirus non-structural protein NS1 ATPase PF06745.13 EFA78457.1 - 0.0018 17.7 7.3 2.4 7.5 0.0 4.6 3 1 1 5 5 5 2 KaiC DUF815 PF05673.13 EFA78457.1 - 0.002 17.4 0.0 0.94 8.6 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 EFA78457.1 - 0.003 17.3 0.2 0.31 10.7 0.0 3.0 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EFA78457.1 - 0.0038 17.2 0.2 3 7.7 0.0 3.2 3 0 0 3 3 2 1 NTPase T2SSE PF00437.20 EFA78457.1 - 0.0038 16.3 0.1 1.6 7.7 0.0 3.4 3 0 0 3 3 3 1 Type II/IV secretion system protein Cytidylate_kin2 PF13189.6 EFA78457.1 - 0.0075 16.4 0.1 1.8 8.7 0.1 2.9 2 1 0 2 2 2 1 Cytidylate kinase-like family AAA_30 PF13604.6 EFA78457.1 - 0.009 15.7 0.0 1.7 8.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFA78457.1 - 0.016 15.5 1.5 10 6.4 1.5 3.1 2 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 EFA78457.1 - 0.056 13.6 0.0 8 6.6 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase_2 PF01637.18 EFA78457.1 - 0.098 12.5 6.4 0.6 10.0 0.0 4.3 4 2 1 5 5 5 0 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 EFA78457.1 - 0.2 11.4 3.0 17 5.1 0.0 3.2 2 1 0 2 2 2 0 Cytidylate kinase DUF2075 PF09848.9 EFA78457.1 - 0.22 10.7 14.2 2.3 7.4 0.0 3.6 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) BMP2K_C PF15282.6 EFA78457.1 - 0.28 11.0 31.1 0.51 10.2 0.8 3.7 3 1 1 4 4 3 0 BMP-2-inducible protein kinase C-terminus PH_4 PF15404.6 EFA78457.1 - 2.2 8.1 12.3 0.91 9.3 4.8 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain AAR2 PF05282.11 EFA78457.1 - 4.7 6.5 12.6 0.18 11.2 1.0 2.5 2 0 0 2 2 2 0 AAR2 protein Ank_2 PF12796.7 EFA78459.1 - 1e-30 106.1 1.0 8.6e-12 45.5 0.2 4.5 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA78459.1 - 3.9e-20 69.8 6.1 0.00066 20.0 0.0 7.7 6 1 1 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFA78459.1 - 1.6e-17 63.3 6.0 0.0016 18.7 0.1 6.1 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFA78459.1 - 3.4e-16 58.9 2.9 0.0021 18.4 0.0 7.3 7 0 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EFA78459.1 - 2e-15 56.9 0.5 0.00052 20.5 0.4 5.6 4 2 3 7 7 7 4 Ankyrin repeats (many copies) NMN_transporter PF04973.12 EFA78462.1 - 0.083 12.9 12.2 0.26 11.3 11.5 2.0 1 1 0 1 1 1 0 Nicotinamide mononucleotide transporter DUF1084 PF06454.11 EFA78462.1 - 2.6 7.3 12.7 4.1 6.7 12.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1084) DUF2975 PF11188.8 EFA78462.1 - 6.2 6.7 11.1 0.2 11.5 0.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2975) GST_C_3 PF14497.6 EFA78463.1 - 2.1e-19 69.5 0.2 3.3e-19 68.9 0.2 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA78463.1 - 2.4e-09 37.3 0.0 4.2e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA78463.1 - 3.7e-09 36.8 0.1 8.6e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA78463.1 - 1.8e-05 24.7 0.0 4.5e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA78463.1 - 0.00035 20.9 0.0 0.00068 20.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFA78463.1 - 0.039 13.7 0.3 0.082 12.7 0.3 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Aldedh PF00171.22 EFA78464.1 - 1.5e-133 445.7 0.0 1.9e-133 445.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFA78464.1 - 0.0048 16.0 0.1 0.016 14.2 0.1 2.1 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) FA_hydroxylase PF04116.13 EFA78465.1 - 4e-29 101.6 15.5 4e-29 101.6 15.5 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily ketoacyl-synt PF00109.26 EFA78466.1 - 3.1e-51 174.4 0.0 4.6e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFA78466.1 - 1.9e-33 114.9 0.0 4.2e-33 113.9 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EFA78466.1 - 0.002 17.6 0.3 0.0032 16.9 0.3 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EFA78466.1 - 0.089 13.2 0.1 0.29 11.6 0.1 1.9 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension Act-Frag_cataly PF09192.10 EFA78467.1 - 2.9e-22 79.4 0.6 2.9e-22 79.4 0.6 1.4 2 0 0 2 2 2 1 Actin-fragmin kinase, catalytic SR-25 PF10500.9 EFA78467.1 - 4.5 6.8 8.8 7.7 6.1 8.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WGG PF10273.9 EFA78468.1 - 6.6e-22 78.0 0.2 1.8e-21 76.6 0.2 1.8 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 EFA78468.1 - 0.007 16.5 0.4 0.015 15.4 0.4 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain YajC PF02699.15 EFA78468.1 - 0.56 10.1 3.6 1.5 8.8 3.6 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit Chromo PF00385.24 EFA78469.1 - 2.4e-11 43.3 0.8 6.9e-11 41.9 0.7 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF908 PF06012.12 EFA78469.1 - 0.044 13.2 8.7 0.055 12.9 8.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CDC45 PF02724.14 EFA78469.1 - 0.066 11.5 10.2 0.073 11.4 10.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 EFA78469.1 - 0.2 9.7 10.5 0.25 9.4 10.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Mitofilin PF09731.9 EFA78469.1 - 0.32 9.8 15.3 0.35 9.7 15.3 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF5531 PF17671.1 EFA78469.1 - 1.5 8.7 8.6 8.3 6.3 8.6 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5531) Ndc1_Nup PF09531.10 EFA78469.1 - 1.8 7.2 9.5 2 7.0 9.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CPSF100_C PF13299.6 EFA78469.1 - 4 7.6 12.5 2.2 8.4 9.7 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pkinase PF00069.25 EFA78470.1 - 9.7e-30 103.8 0.2 9.7e-30 103.8 0.2 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78470.1 - 4.2e-17 62.3 0.1 8.1e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 EFA78470.1 - 9.4e-11 42.1 7.5 0.0046 17.8 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78470.1 - 7.6e-08 32.6 0.0 0.066 13.5 0.0 4.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ipi1_N PF12333.8 EFA78470.1 - 0.16 12.6 2.5 0.53 10.9 1.8 2.2 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Sde2_N_Ubi PF13019.6 EFA78471.1 - 1.7e-27 96.2 0.6 1.7e-27 96.2 0.6 2.3 1 1 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain Mucin PF01456.17 EFA78471.1 - 0.0022 18.0 25.7 0.0042 17.1 25.7 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.11 EFA78471.1 - 0.35 9.0 16.1 0.48 8.6 16.1 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 EFA78471.1 - 0.57 8.2 9.3 0.79 7.8 9.3 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Med13_C PF06333.12 EFA78471.1 - 1.9 7.6 11.5 3.4 6.8 11.5 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Band_3_cyto PF07565.13 EFA78471.1 - 2.3 7.9 8.5 3.3 7.4 8.5 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pex14_N PF04695.13 EFA78471.1 - 3 8.5 13.4 5.6 7.6 13.4 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2981 PF11200.8 EFA78471.1 - 6.1 6.5 17.1 3.3 7.4 13.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) Mito_carr PF00153.27 EFA78472.1 - 2e-66 220.0 3.4 2.9e-24 84.8 0.4 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein 2OG-FeII_Oxy_3 PF13640.6 EFA78472.1 - 6.9e-09 36.5 0.0 1.3e-08 35.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Serine_protease PF18405.1 EFA78472.1 - 0.011 14.9 0.9 0.13 11.4 0.1 2.7 2 1 1 3 3 3 0 Gammaproteobacterial serine protease 2OG-FeII_Oxy PF03171.20 EFA78472.1 - 0.035 14.6 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily ORC6 PF05460.13 EFA78472.1 - 0.12 11.6 13.8 0.22 10.7 13.8 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Hamartin PF04388.12 EFA78472.1 - 0.13 10.9 11.2 0.21 10.2 11.2 1.3 1 0 0 1 1 1 0 Hamartin protein Dicty_REP PF05086.12 EFA78472.1 - 1.1 7.2 9.9 1.7 6.5 9.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PRCC PF10253.9 EFA78472.1 - 2.3 8.9 10.7 4.8 7.9 10.7 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DAAD PF18752.1 EFA78472.1 - 3.4 7.4 18.0 84 2.9 17.7 2.9 2 1 0 2 2 2 0 Dictyosteliid AID/APOBEC-like Deaminase Med13_C PF06333.12 EFA78472.1 - 3.5 6.8 19.8 0.2 10.9 14.4 1.5 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain FYVE PF01363.21 EFA78473.1 - 1.2e-17 63.8 12.7 1.2e-17 63.8 12.7 2.1 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.29 EFA78473.1 - 1.6e-12 47.9 7.3 6.9e-09 36.2 0.1 3.7 4 1 0 4 4 4 2 PH domain PH_11 PF15413.6 EFA78473.1 - 1.7e-05 25.2 10.8 0.00056 20.3 0.1 3.8 3 1 0 3 3 2 2 Pleckstrin homology domain PH_3 PF14593.6 EFA78473.1 - 9.8e-05 22.4 0.4 0.0029 17.7 0.0 2.7 3 0 0 3 3 3 1 PH domain PHM7_cyt PF14703.6 EFA78473.1 - 0.0019 18.5 0.7 0.0041 17.4 0.7 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter UPF0242 PF06785.11 EFA78473.1 - 0.0023 18.1 1.4 0.0035 17.5 1.4 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus PH_8 PF15409.6 EFA78473.1 - 0.0068 16.7 0.2 0.22 11.8 0.0 3.1 3 0 0 3 3 3 1 Pleckstrin homology domain NYD-SP28 PF14772.6 EFA78473.1 - 0.032 14.3 2.3 0.058 13.5 2.3 1.4 1 0 0 1 1 1 0 Sperm tail RdgC PF04381.12 EFA78473.1 - 0.15 11.3 0.4 0.23 10.7 0.4 1.2 1 0 0 1 1 1 0 Putative exonuclease, RdgC Golgin_A5 PF09787.9 EFA78473.1 - 0.22 10.9 6.3 0.33 10.4 6.3 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 zf-FCS PF06467.14 EFA78473.1 - 0.34 10.9 0.1 0.34 10.9 0.1 3.0 2 1 0 2 2 1 0 MYM-type Zinc finger with FCS sequence motif FYVE_2 PF02318.16 EFA78473.1 - 1.1 9.4 18.0 0.18 12.0 9.8 2.6 2 1 0 2 2 2 0 FYVE-type zinc finger ALMT PF11744.8 EFA78473.1 - 2.6 6.8 8.0 4.2 6.1 8.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CBS PF00571.28 EFA78474.1 - 5.1e-22 78.1 0.9 3.8e-09 36.9 0.0 3.9 4 0 0 4 4 4 3 CBS domain DUF1043 PF06295.12 EFA78475.1 - 0.00065 19.7 2.2 0.0007 19.6 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) LapA_dom PF06305.11 EFA78475.1 - 0.013 15.3 0.1 0.015 15.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain GPHR_N PF12537.8 EFA78475.1 - 3 8.0 4.1 16 5.6 4.1 1.9 1 1 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Glycos_transf_1 PF00534.20 EFA78476.1 - 9.7e-16 57.8 0.0 1.8e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA78476.1 - 2.2e-09 37.9 0.0 3.9e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFA78476.1 - 1.7e-06 28.4 0.0 4.4e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Fes1 PF08609.10 EFA78476.1 - 0.018 15.9 1.8 0.92 10.4 0.2 3.0 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 Ribosomal_L32p PF01783.23 EFA78477.1 - 3.8e-11 43.1 10.7 7.5e-11 42.1 10.7 1.5 1 0 0 1 1 1 1 Ribosomal L32p protein family DZR PF12773.7 EFA78477.1 - 0.055 13.5 1.3 0.087 12.9 1.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon Metallophos PF00149.28 EFA78478.1 - 7.2e-36 124.6 0.6 1.2e-35 123.9 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFA78478.1 - 3.6e-05 24.1 0.1 7e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 EFA78478.1 - 0.013 15.1 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain zf-HYPF PF07503.12 EFA78478.1 - 0.065 13.0 0.9 1.3 8.8 0.0 2.8 2 0 0 2 2 2 0 HypF finger Metallophos_2 PF12850.7 EFA78478.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain CDC45 PF02724.14 EFA78479.1 - 9.4e-159 529.7 11.3 2.3e-158 528.4 11.3 1.6 1 1 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EFA78479.1 - 0.016 14.6 32.5 0.024 14.0 32.5 1.1 1 0 0 1 1 1 0 BUD22 Ank_2 PF12796.7 EFA78479.1 - 0.054 14.1 0.1 4.1 8.1 0.0 3.0 2 1 1 3 3 3 0 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78479.1 - 0.16 12.4 0.2 6.8 7.1 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Connexin PF00029.19 EFA78479.1 - 0.51 10.1 2.2 1.3 8.7 2.2 1.7 1 1 0 1 1 1 0 Connexin SDA1 PF05285.12 EFA78479.1 - 1.3 8.4 36.6 2.1 7.7 36.6 1.2 1 0 0 1 1 1 0 SDA1 Astro_capsid_p PF12226.8 EFA78479.1 - 1.3 8.1 23.7 4.2 6.4 23.7 1.8 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 EFA78479.1 - 2.3 6.3 36.3 3.6 5.7 36.3 1.2 1 0 0 1 1 1 0 Nop14-like family EIIBC-GUT_N PF03612.14 EFA78479.1 - 5 6.8 8.1 6.7 6.4 0.1 2.8 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2457 PF10446.9 EFA78479.1 - 7.7 5.5 38.3 13 4.7 38.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) VCBS PF13517.6 EFA78481.1 - 2.1e-32 111.5 23.1 6.1e-12 45.9 1.8 5.8 3 3 3 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.12 EFA78481.1 - 1.3e-17 63.5 0.0 3.1e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.23 EFA78481.1 - 4.8e-11 42.6 26.0 0.0068 16.5 0.0 7.6 8 0 0 8 8 8 5 FG-GAP repeat Bromo_TP_like PF17027.5 EFA78481.1 - 0.0018 18.4 0.0 0.0045 17.1 0.0 1.6 1 0 0 1 1 1 1 Histone-fold protein Sec8_exocyst PF04048.14 EFA78481.1 - 0.068 13.0 2.5 0.14 12.1 2.5 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF3450 PF11932.8 EFA78481.1 - 0.079 12.3 3.0 0.12 11.7 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FNIP PF05725.12 EFA78482.1 - 1.1e-37 127.9 20.9 4.7e-13 49.1 0.4 6.0 3 1 3 7 7 7 6 FNIP Repeat Sld5 PF05916.11 EFA78483.1 - 1.7e-05 25.2 0.7 3.7e-05 24.1 0.7 1.5 1 0 0 1 1 1 1 GINS complex protein C_Hendra PF16821.5 EFA78483.1 - 0.04 13.8 0.5 0.074 12.9 0.5 1.4 1 0 0 1 1 1 0 C protein from hendra and measles viruses DUF2277 PF10041.9 EFA78483.1 - 0.055 13.8 0.1 0.097 13.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) DUF2935 PF11155.8 EFA78483.1 - 0.33 11.3 3.2 0.47 10.8 0.4 2.4 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) DHR-2 PF06920.13 EFA78484.1 - 7.1e-161 536.4 14.8 1.9e-158 528.4 14.8 2.5 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EFA78484.1 - 3.3e-22 79.3 0.8 1.4e-21 77.2 0.1 2.4 2 1 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 EFA78484.1 - 9.1e-05 22.9 0.0 0.001 19.5 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3398) Colicin_Pyocin PF01320.18 EFA78484.1 - 0.089 12.9 0.1 9 6.5 0.0 3.0 2 0 0 2 2 2 0 Colicin immunity protein / pyocin immunity protein MARVEL PF01284.23 EFA78487.1 - 0.005 16.9 11.3 0.0074 16.3 11.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain CD20 PF04103.15 EFA78487.1 - 0.17 11.9 8.0 0.15 12.1 6.5 1.6 1 1 0 1 1 1 0 CD20-like family DUF2207 PF09972.9 EFA78487.1 - 0.24 10.1 4.6 0.29 9.9 4.1 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4267 PF14087.6 EFA78487.1 - 0.28 11.2 2.9 0.26 11.4 1.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4267) DUF2070 PF09843.9 EFA78487.1 - 3.5 5.8 9.0 7 4.8 9.0 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF308 PF03729.13 EFA78487.1 - 4.7 7.6 12.1 0.39 11.1 1.7 2.5 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) Helicase_C_2 PF13307.6 EFA78488.1 - 7.5e-47 159.7 0.1 1.6e-46 158.6 0.1 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 EFA78488.1 - 2.5e-34 118.6 0.1 1.7e-30 106.2 0.0 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain DEAD_2 PF06733.15 EFA78488.1 - 9.4e-19 67.7 4.3 6.9e-13 48.6 2.3 2.7 1 1 1 2 2 2 2 DEAD_2 ResIII PF04851.15 EFA78488.1 - 7.9e-05 22.7 0.0 0.00017 21.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA78488.1 - 0.00052 19.8 0.0 0.0014 18.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA78488.1 - 0.00083 19.6 0.0 0.0041 17.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain DarT PF14487.6 EFA78488.1 - 0.02 14.7 0.1 3.4 7.5 0.1 2.3 2 0 0 2 2 2 0 ssDNA thymidine ADP-ribosyltransferase, DarT DUF2075 PF09848.9 EFA78488.1 - 0.034 13.4 0.0 0.068 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PolyA_pol_RNAbd PF12627.7 EFA78488.1 - 0.15 11.9 0.0 0.4 10.5 0.0 1.7 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A TPR_17 PF13431.6 EFA78491.1 - 0.0023 18.2 0.1 5.5 7.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat ISK_Channel PF02060.15 EFA78491.1 - 0.22 11.2 0.9 0.87 9.3 0.1 2.5 2 0 0 2 2 2 0 Slow voltage-gated potassium channel VMA21 PF09446.10 EFA78491.1 - 0.23 11.6 4.1 9.1 6.5 0.7 3.1 2 0 0 2 2 2 0 VMA21-like domain Orf78 PF06024.12 EFA78491.1 - 0.23 11.8 0.0 0.23 11.8 0.0 5.8 6 0 0 6 6 6 0 Orf78 (ac78) AAA PF00004.29 EFA78492.1 - 7.3e-57 191.5 0.0 4.5e-45 153.3 0.0 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA78492.1 - 3.1e-10 40.7 0.5 0.021 15.2 0.0 4.0 4 0 0 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 EFA78492.1 - 8.3e-09 35.6 0.8 0.00038 20.5 0.0 3.8 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EFA78492.1 - 3.6e-08 33.1 0.0 0.0087 15.8 0.2 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_18 PF13238.6 EFA78492.1 - 2.8e-07 31.1 0.5 0.091 13.3 0.0 4.0 4 0 0 4 4 4 2 AAA domain AAA_14 PF13173.6 EFA78492.1 - 5.9e-06 26.3 0.3 0.21 11.6 0.0 4.0 4 0 0 4 4 3 2 AAA domain RuvB_N PF05496.12 EFA78492.1 - 6.3e-06 26.0 0.0 0.0002 21.1 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFA78492.1 - 9.3e-06 26.0 0.0 0.0091 16.4 0.0 3.6 3 0 0 3 3 2 1 RNA helicase AAA_33 PF13671.6 EFA78492.1 - 1.9e-05 24.8 0.1 0.092 12.9 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 EFA78492.1 - 4.9e-05 23.6 0.3 0.053 13.8 0.0 3.5 2 2 1 3 3 3 1 AAA domain TsaE PF02367.17 EFA78492.1 - 5.9e-05 23.1 0.0 0.23 11.5 0.0 2.8 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EFA78492.1 - 6e-05 22.3 0.0 0.00017 20.8 0.0 1.7 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EFA78492.1 - 0.00033 20.9 0.0 0.21 11.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EFA78492.1 - 0.00042 20.5 0.0 0.037 14.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EFA78492.1 - 0.00067 19.2 0.0 0.096 12.2 0.0 3.4 3 0 0 3 3 3 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EFA78492.1 - 0.00079 19.2 0.0 0.009 15.8 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.13 EFA78492.1 - 0.001 18.4 0.0 0.032 13.4 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EFA78492.1 - 0.0021 17.4 0.2 0.045 13.1 0.1 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EFA78492.1 - 0.0023 18.5 2.8 4.7 7.7 0.0 3.8 3 0 0 3 3 3 1 ABC transporter NACHT PF05729.12 EFA78492.1 - 0.0023 17.9 0.9 2.7 7.9 0.0 3.2 3 1 0 3 3 2 1 NACHT domain AAA_17 PF13207.6 EFA78492.1 - 0.0043 17.5 0.2 1.4 9.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 EFA78492.1 - 0.0048 16.8 0.1 0.53 10.2 0.1 3.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_29 PF13555.6 EFA78492.1 - 0.008 15.9 0.2 1.3 8.8 0.0 3.0 2 1 0 2 2 2 1 P-loop containing region of AAA domain SKI PF01202.22 EFA78492.1 - 0.014 15.5 0.0 1.7 8.7 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase Sigma54_activat PF00158.26 EFA78492.1 - 0.014 15.1 0.0 3 7.5 0.0 2.8 3 0 0 3 3 2 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 EFA78492.1 - 0.018 15.0 0.0 0.35 10.7 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EFA78492.1 - 0.021 14.5 0.0 0.82 9.4 0.0 2.9 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 EFA78492.1 - 0.029 13.6 0.0 6.4 5.9 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain ATPase PF06745.13 EFA78492.1 - 0.056 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EFA78492.1 - 0.056 13.0 0.8 0.84 9.2 0.1 2.6 2 1 1 3 3 3 0 AAA domain AAA_3 PF07726.11 EFA78492.1 - 0.056 13.3 0.0 3.4 7.5 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EFA78492.1 - 0.078 12.7 0.0 15 5.3 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase TFIIE-A_C PF11521.8 EFA78492.1 - 0.079 13.3 4.3 0.26 11.6 4.3 1.9 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha ADH_zinc_N PF00107.26 EFA78493.1 - 4.8e-27 94.5 0.0 7.6e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA78493.1 - 2e-19 71.0 0.0 6e-19 69.4 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA78493.1 - 1.5e-10 40.9 0.0 3.6e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 EFA78493.1 - 9.2e-05 22.0 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus PALP PF00291.25 EFA78493.1 - 0.0012 18.3 0.2 0.0019 17.7 0.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TrkA_N PF02254.18 EFA78493.1 - 0.06 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 EFA78493.1 - 0.11 11.8 0.1 0.24 10.7 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Phosphodiest PF01663.22 EFA78494.1 - 2.7e-06 27.2 0.2 5.1e-05 23.0 0.2 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Peptidase_S9 PF00326.21 EFA78494.1 - 0.00097 18.7 0.0 0.0082 15.6 0.0 2.4 3 0 0 3 3 3 1 Prolyl oligopeptidase family Esterase PF00756.20 EFA78494.1 - 0.0014 18.3 0.5 0.0065 16.1 0.6 2.0 1 1 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 EFA78494.1 - 0.0037 17.9 0.7 0.008 16.8 0.7 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family MutS_V PF00488.21 EFA78495.1 - 1.4e-81 273.0 0.3 3e-81 271.9 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EFA78495.1 - 4.1e-40 136.6 0.1 9.1e-40 135.4 0.1 1.7 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 EFA78495.1 - 6.4e-36 124.4 3.7 6.4e-36 124.4 3.7 1.9 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EFA78495.1 - 5.2e-20 71.6 1.6 2e-19 69.7 1.6 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EFA78495.1 - 1e-12 48.5 0.1 7.2e-12 45.8 0.0 2.5 3 0 0 3 3 3 1 MutS domain II zf_CopZ PF18423.1 EFA78495.1 - 0.093 12.7 0.2 0.37 10.8 0.2 2.0 1 0 0 1 1 1 0 Zinc binding domain MSA-2c PF12238.8 EFA78496.1 - 0.02 14.9 0.4 0.044 13.8 0.4 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c RRM_2 PF04059.12 EFA78497.1 - 7e-33 112.7 0.1 1.6e-32 111.5 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EFA78497.1 - 3.3e-25 87.7 1.1 6.1e-10 38.8 0.1 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA78497.1 - 4.2e-12 45.7 0.1 5.2e-06 26.1 0.0 2.9 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA78497.1 - 8.4e-05 22.4 0.1 0.06 13.2 0.0 2.8 2 0 0 2 2 2 2 Occluded RNA-recognition motif BRAP2 PF07576.12 EFA78497.1 - 0.0022 18.2 0.3 0.0094 16.2 0.0 2.1 2 0 0 2 2 2 1 BRCA1-associated protein 2 SUIM_assoc PF16619.5 EFA78497.1 - 5.5 7.1 33.8 0.22 11.6 4.2 5.1 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 CBM_X2 PF03442.14 EFA78498.1 - 0.14 12.3 3.5 1 9.5 0.1 2.7 3 0 0 3 3 3 0 Carbohydrate binding domain X2 UCH PF00443.29 EFA78499.1 - 4.9e-22 78.7 13.7 4.9e-22 78.7 13.7 5.0 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA78499.1 - 9.2e-06 25.5 18.1 9.2e-06 25.5 18.1 4.1 2 2 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EFA78499.1 - 0.005 16.4 8.7 0.097 12.1 0.4 2.9 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Phospholip_B PF04916.13 EFA78500.1 - 1.5e-186 621.1 20.1 1.9e-186 620.8 20.1 1.0 1 0 0 1 1 1 1 Phospholipase B RasGEF PF00617.19 EFA78501.1 - 2.7e-40 138.5 0.3 8.7e-40 136.8 0.3 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA78501.1 - 3.3e-11 43.3 4.9 8.2e-11 42.1 2.3 2.8 2 1 0 2 2 2 1 RasGEF N-terminal motif LisH_TPL PF17814.1 EFA78501.1 - 9.7e-05 21.9 0.7 0.00029 20.4 0.7 1.8 1 0 0 1 1 1 1 LisH-like dimerisation domain SAC3_GANP PF03399.16 EFA78501.1 - 0.021 14.2 3.3 0.84 9.0 0.3 3.2 2 1 0 3 3 3 0 SAC3/GANP family zf-C3HC4 PF00097.25 EFA78502.1 - 1.2e-11 44.3 7.5 2.3e-11 43.4 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA78502.1 - 5.3e-11 42.2 8.4 8.2e-11 41.6 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA78502.1 - 6.2e-11 42.0 5.2 9.7e-11 41.4 5.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA78502.1 - 4.1e-10 39.5 7.4 6.5e-10 38.8 7.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA78502.1 - 5.4e-10 39.4 9.5 8.5e-10 38.8 9.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA78502.1 - 1.5e-09 37.7 6.7 1.6e-09 37.6 3.7 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFA78502.1 - 1.6e-07 31.4 10.2 2.6e-07 30.7 10.2 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFA78502.1 - 2.4e-06 27.3 6.9 4.3e-06 26.5 6.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFA78502.1 - 4.6e-06 26.8 6.4 9.5e-06 25.8 6.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.8 EFA78502.1 - 9.1e-05 22.2 3.9 0.00017 21.3 3.9 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 EFA78502.1 - 0.00018 21.5 3.8 0.0003 20.8 3.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EFA78502.1 - 0.00065 19.5 2.5 0.0012 18.7 2.5 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Rtf2 PF04641.12 EFA78502.1 - 0.0043 16.5 6.1 0.0043 16.5 6.1 2.1 1 1 1 2 2 2 1 Rtf2 RING-finger U-box PF04564.15 EFA78502.1 - 0.0076 16.4 1.1 0.037 14.2 0.0 2.4 1 1 1 2 2 2 1 U-box domain zf-UDP PF14569.6 EFA78502.1 - 0.021 15.0 4.4 0.081 13.1 4.4 1.9 1 1 0 1 1 1 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 EFA78502.1 - 0.037 13.7 6.8 0.06 13.0 6.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF4064 PF13273.6 EFA78502.1 - 0.04 14.2 1.0 0.04 14.2 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Dicty_REP PF05086.12 EFA78502.1 - 0.048 11.6 7.4 0.049 11.6 7.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-P11 PF03854.14 EFA78502.1 - 0.076 12.7 4.9 0.14 11.8 4.9 1.4 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 EFA78502.1 - 0.19 11.5 8.2 0.69 9.8 8.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EFA78502.1 - 0.42 10.8 3.7 0.74 10.0 3.7 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 CTU2 PF10288.9 EFA78502.1 - 0.81 10.0 12.3 23 5.3 0.0 2.7 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-RING_11 PF17123.5 EFA78502.1 - 0.91 9.3 10.1 0.4 10.5 6.1 2.2 2 0 0 2 2 2 0 RING-like zinc finger Pex14_N PF04695.13 EFA78502.1 - 1.8 9.2 8.9 0.58 10.8 4.0 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region V_ATPase_I PF01496.19 EFA78502.1 - 2.7 5.8 5.9 3.3 5.5 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 EFA78502.1 - 7.8 5.2 9.3 12 4.5 9.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 GST_C_3 PF14497.6 EFA78503.1 - 1.1e-18 67.3 0.2 2.3e-18 66.2 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA78503.1 - 9.9e-11 41.8 0.0 6.8e-10 39.2 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA78503.1 - 2.6e-05 24.1 0.0 6.6e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA78503.1 - 3.6e-05 23.9 0.2 0.00015 22.0 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA78503.1 - 0.064 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Acetyltransf_10 PF13673.7 EFA78504.1 - 2.8e-10 40.2 0.1 4.7e-10 39.5 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA78504.1 - 4.3e-10 39.9 0.0 5.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA78504.1 - 7.3e-09 35.9 0.0 1.3e-08 35.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFA78504.1 - 0.0068 16.4 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFA78504.1 - 0.054 13.6 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Cys_rich_FGFR PF00839.17 EFA78504.1 - 0.062 13.5 0.3 0.15 12.3 0.1 1.7 2 0 0 2 2 2 0 Cysteine rich repeat Acetyltransf_4 PF13420.7 EFA78504.1 - 0.088 12.9 0.3 0.37 10.9 0.3 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFA78504.1 - 0.088 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain tRNA_int_end_N2 PF12928.7 EFA78505.1 - 5.4e-10 39.3 0.3 3.1e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EFA78505.1 - 0.0011 18.5 0.1 0.0027 17.4 0.1 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain F-box PF00646.33 EFA78509.1 - 0.00021 21.1 0.3 0.00052 19.8 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA78509.1 - 0.001 18.9 2.0 0.0012 18.7 0.3 2.0 3 0 0 3 3 3 1 F-box-like DUF4834 PF16118.5 EFA78509.1 - 0.093 13.7 1.6 0.18 12.8 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) 4HBT PF03061.22 EFA78510.1 - 9.7e-09 35.5 0.4 6.7e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily RRM_1 PF00076.22 EFA78510.1 - 8.2e-06 25.5 0.0 2.3e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MaoC_dehydratas PF01575.19 EFA78510.1 - 0.14 11.7 0.2 0.44 10.1 0.1 1.9 2 0 0 2 2 2 0 MaoC like domain Ald_Xan_dh_C2 PF02738.18 EFA78511.1 - 5.8e-202 672.0 0.0 8.1e-202 671.5 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EFA78511.1 - 7.4e-45 152.7 0.1 2.1e-44 151.3 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EFA78511.1 - 1.5e-33 115.0 0.0 3.8e-33 113.7 0.0 1.7 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EFA78511.1 - 7.7e-30 102.7 0.2 2.1e-29 101.4 0.2 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.22 EFA78511.1 - 2.6e-27 95.3 1.0 5.6e-27 94.3 1.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.27 EFA78511.1 - 2.2e-08 33.9 0.1 2.2e-08 33.9 0.1 2.4 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.9 EFA78511.1 - 0.092 12.6 1.8 0.34 10.7 1.8 2.0 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Pkinase PF00069.25 EFA78512.1 - 3.2e-80 269.3 0.5 3.7e-80 269.1 0.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78512.1 - 2.2e-37 128.8 0.2 2.5e-37 128.6 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA78512.1 - 2.2e-10 40.3 0.1 1.9e-08 34.0 0.0 2.1 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFA78512.1 - 9.5e-06 24.6 0.2 5.9e-05 22.0 0.0 1.9 1 1 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFA78512.1 - 1.4e-05 24.6 0.1 2.2e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA78512.1 - 7.1e-05 22.8 0.0 0.014 15.3 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EFA78512.1 - 0.0011 18.6 0.6 0.0018 17.9 0.6 1.2 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 EFA78512.1 - 0.0011 18.6 1.4 0.073 12.7 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EFA78512.1 - 0.0072 15.3 0.7 0.011 14.7 0.7 1.4 1 1 0 1 1 1 1 Haspin like kinase domain PIP5K PF01504.18 EFA78513.1 - 1.9e-73 247.1 0.8 1.9e-73 247.1 0.8 3.8 4 0 0 4 4 4 1 Phosphatidylinositol-4-phosphate 5-Kinase C1_1 PF00130.22 EFA78513.1 - 1.8e-12 46.9 5.0 3.3e-12 46.1 5.0 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.6 EFA78513.1 - 3e-11 43.6 2.7 1.6e-07 31.6 0.0 3.8 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFA78513.1 - 1.8e-08 33.3 0.4 0.00076 18.9 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA78513.1 - 2.5e-08 33.2 0.5 0.00023 20.9 0.0 3.3 2 0 0 2 2 2 2 EF-hand domain DUF4306 PF14154.6 EFA78513.1 - 0.0022 18.1 0.3 0.0065 16.6 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4306) EF-hand_5 PF13202.6 EFA78513.1 - 0.0074 15.7 0.2 0.49 10.0 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFA78513.1 - 0.022 14.6 0.2 0.066 13.1 0.2 1.9 1 1 0 1 1 1 0 EF-hand domain pair C1_2 PF03107.16 EFA78513.1 - 0.039 14.3 3.1 0.11 12.8 3.1 1.9 1 0 0 1 1 1 0 C1 domain CSN4_RPN5_eIF3a PF18420.1 EFA78517.1 - 0.096 12.9 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 CSN4/RPN5/eIF3a helix turn helix domain M157 PF11624.8 EFA78519.1 - 0.0025 17.2 0.6 0.0029 17.0 0.6 1.1 1 0 0 1 1 1 1 MHC class I-like protein M157 LytR_C PF13399.6 EFA78519.1 - 0.081 13.9 0.2 0.09 13.8 0.2 1.3 1 1 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator zf-A20 PF01754.16 EFA78520.1 - 3.7e-11 42.7 8.4 3.7e-11 42.7 8.4 2.1 2 0 0 2 2 2 1 A20-like zinc finger zf-AN1 PF01428.16 EFA78520.1 - 4.1e-10 39.7 10.8 4.1e-10 39.7 10.8 2.6 2 1 0 2 2 2 1 AN1-like Zinc finger DZR PF12773.7 EFA78520.1 - 1.4 9.0 10.3 4.7 7.3 10.2 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-RanBP PF00641.18 EFA78520.1 - 4.1 6.8 10.6 12 5.4 0.5 3.0 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others IBR PF01485.21 EFA78521.1 - 9.6e-10 38.6 36.9 8.5e-08 32.3 10.1 3.9 2 1 2 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFA78521.1 - 0.0067 16.3 3.0 0.0067 16.3 3.0 4.9 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA78521.1 - 0.0091 15.8 0.7 0.0091 15.8 0.7 5.2 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) DUF3268 PF11672.8 EFA78521.1 - 0.052 13.9 0.0 0.052 13.9 0.0 2.7 2 1 1 3 3 3 0 zinc-finger-containing domain E6 PF00518.17 EFA78521.1 - 0.25 11.8 19.0 0.15 12.6 3.5 3.7 2 1 1 3 3 3 0 Early Protein (E6) DCX PF03607.17 EFA78522.1 - 3.4e-34 116.8 0.6 3.7e-17 62.2 0.0 2.3 2 0 0 2 2 2 2 Doublecortin UB2H PF14814.6 EFA78522.1 - 0.028 14.4 0.1 2.4 8.2 0.0 2.5 2 1 0 2 2 2 0 Bifunctional transglycosylase second domain ubiquitin PF00240.23 EFA78522.1 - 0.037 13.8 1.7 0.54 10.0 0.2 2.6 2 1 0 2 2 2 0 Ubiquitin family DUF2914 PF11141.8 EFA78522.1 - 0.068 12.9 0.6 2.2 8.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) Ribosomal_L12_N PF16320.5 EFA78522.1 - 0.17 11.6 0.1 0.48 10.2 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain DUF1410 PF07198.11 EFA78522.1 - 0.18 12.3 0.6 0.43 11.1 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1410) TRAPP PF04051.16 EFA78523.1 - 3.2e-35 121.0 0.2 4.9e-35 120.4 0.2 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DAD PF02109.16 EFA78523.1 - 2.7e-23 82.4 2.5 6.3e-23 81.2 2.2 1.8 2 0 0 2 2 2 1 DAD family Bax1-I PF01027.20 EFA78523.1 - 0.0022 17.8 2.6 0.0034 17.3 2.6 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Synaptonemal_3 PF15191.6 EFA78523.1 - 0.16 11.8 0.4 5.8 6.8 0.0 2.4 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 DMAP1 PF05499.12 EFA78524.1 - 0.016 15.1 0.9 0.033 14.1 0.9 1.4 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) NOA36 PF06524.12 EFA78524.1 - 0.33 10.2 8.3 0.54 9.5 8.3 1.3 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EFA78524.1 - 3.4 7.3 18.2 0.55 9.9 13.4 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FYDLN_acid PF09538.10 EFA78524.1 - 5.5 7.7 11.9 17 6.2 11.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Nop25 PF09805.9 EFA78524.1 - 9.1 6.8 9.3 24 5.4 9.3 1.6 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) zf-B_box PF00643.24 EFA78526.1 - 7.2e-06 26.1 5.1 1.4e-05 25.1 5.1 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA78526.1 - 0.00038 20.6 8.3 0.23 11.8 0.1 4.9 5 0 0 5 5 5 1 Kelch motif DUF5074 PF16819.5 EFA78526.1 - 0.021 14.8 2.2 2.3 8.3 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) Tis11B_N PF04553.12 EFA78526.1 - 0.046 14.3 0.9 0.046 14.3 0.9 1.8 2 0 0 2 2 2 0 Tis11B like protein, N terminus Kelch_1 PF01344.25 EFA78526.1 - 0.051 13.2 3.0 0.54 9.9 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA78526.1 - 0.098 12.7 2.5 45 4.2 0.1 4.2 4 0 0 4 4 4 0 Galactose oxidase, central domain APG6_N PF17675.1 EFA78526.1 - 0.12 12.9 0.3 0.12 12.9 0.3 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region Snapin_Pallidin PF14712.6 EFA78526.1 - 0.23 11.9 8.1 2.4 8.6 0.0 3.4 3 0 0 3 3 3 0 Snapin/Pallidin Fzo_mitofusin PF04799.13 EFA78526.1 - 1.2 8.6 6.8 6.4 6.3 0.4 2.6 1 1 1 2 2 2 0 fzo-like conserved region NT-C2 PF10358.9 EFA78527.1 - 2.8e-24 85.5 5.1 9e-24 83.9 5.1 1.9 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EFA78527.1 - 6.7e-20 71.3 0.8 4.6e-19 68.6 0.1 3.0 2 0 0 2 2 2 1 DIL domain UPF0242 PF06785.11 EFA78527.1 - 0.0011 19.1 14.0 0.0011 19.1 14.0 6.1 5 2 0 5 5 5 1 Uncharacterised protein family (UPF0242) N-terminus DUF3915 PF13054.6 EFA78527.1 - 0.0014 18.6 0.5 0.0014 18.6 0.5 4.5 4 1 1 5 5 5 1 Protein of unknown function (DUF3915) Tropomyosin_1 PF12718.7 EFA78527.1 - 0.0063 16.7 20.7 0.0063 16.7 20.7 6.7 4 2 2 6 6 6 2 Tropomyosin like SlyX PF04102.12 EFA78527.1 - 0.0089 16.6 0.1 0.0089 16.6 0.1 8.3 6 1 2 8 8 8 3 SlyX FlxA PF14282.6 EFA78527.1 - 0.012 15.6 1.8 0.012 15.6 1.8 9.4 3 2 3 7 7 7 0 FlxA-like protein YabA PF06156.13 EFA78527.1 - 0.014 16.0 0.4 0.014 16.0 0.4 8.0 4 2 3 7 7 7 0 Initiation control protein YabA Telomerase_RBD PF12009.8 EFA78527.1 - 0.039 14.1 1.2 0.13 12.3 1.2 1.9 1 0 0 1 1 1 0 Telomerase ribonucleoprotein complex - RNA binding domain ACDC PF14733.6 EFA78527.1 - 5.8 7.3 9.4 0.64 10.4 2.6 2.9 3 1 0 3 3 3 0 AP2-coincident C-terminal FA_hydroxylase PF04116.13 EFA78529.1 - 2.3e-14 53.9 15.0 3.5e-14 53.3 15.0 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily SbmA_BacA PF05992.12 EFA78530.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 SbmA/BacA-like family ACOX PF01756.19 EFA78532.1 - 5.5e-27 94.5 0.0 1.1e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFA78532.1 - 3.6e-15 55.9 0.0 7.1e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFA78532.1 - 6.2e-09 36.2 0.1 1.1e-08 35.4 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain EVE PF01878.18 EFA78533.1 - 5.1e-15 55.7 0.0 6e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 EVE domain Chlam_PMP PF02415.17 EFA78535.1 - 3.1e-06 27.3 78.4 0.0071 16.8 2.1 11.7 11 1 0 11 11 11 9 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF1161 PF06649.12 EFA78535.1 - 0.066 13.4 0.1 0.31 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1161) EGF_2 PF07974.13 EFA78535.1 - 0.47 10.9 3.2 1.5 9.3 3.2 1.9 1 0 0 1 1 1 0 EGF-like domain dCMP_cyt_deam_1 PF00383.23 EFA78536.1 - 2.1e-11 43.6 0.1 3.8e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFA78536.1 - 2.6e-05 24.0 0.1 4.2e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EFA78536.1 - 0.098 12.7 0.5 4.2 7.5 0.5 2.2 1 1 0 1 1 1 0 Bd3614-like deaminase Stc1 PF12898.7 EFA78536.1 - 0.29 11.7 2.3 0.24 12.0 0.3 1.9 2 1 0 2 2 2 0 Stc1 domain WD40 PF00400.32 EFA78537.1 - 4.1e-05 24.2 1.6 17 6.4 0.0 5.9 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78537.1 - 0.0006 20.1 0.0 0.064 13.6 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA78537.1 - 1.3 9.1 4.8 3.5 7.7 0.0 3.9 4 1 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region DUF2076 PF09849.9 EFA78538.1 - 3.2e-05 24.1 2.2 3.6e-05 23.9 2.2 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Pet191_N PF10203.9 EFA78538.1 - 0.0094 16.2 1.6 0.015 15.6 1.6 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 NPBW PF15180.6 EFA78538.1 - 0.035 13.9 0.3 0.072 13.0 0.0 1.6 2 0 0 2 2 2 0 Neuropeptides B and W CHCH PF06747.13 EFA78538.1 - 0.037 14.2 3.1 0.068 13.3 3.1 1.4 1 0 0 1 1 1 0 CHCH domain DUF2613 PF11021.8 EFA78538.1 - 0.073 13.2 1.0 0.073 13.2 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) COX6B PF02297.17 EFA78538.1 - 0.13 12.5 5.3 0.29 11.4 5.3 1.5 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb UPF0203 PF05254.12 EFA78538.1 - 0.99 9.7 5.5 0.49 10.7 0.3 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) WD40 PF00400.32 EFA78539.1 - 4e-35 119.2 2.7 9.8e-06 26.2 0.0 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78539.1 - 0.013 15.7 0.8 6.4 7.1 0.0 4.2 4 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DUF728 PF05304.12 EFA78539.1 - 0.37 10.6 2.5 0.34 10.7 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF728) FNIP PF05725.12 EFA78540.1 - 4.5e-113 369.2 69.6 5.4e-16 58.5 0.3 11.2 7 2 4 11 11 11 11 FNIP Repeat Pkinase PF00069.25 EFA78540.1 - 1.1e-24 87.2 1.5 2.9e-19 69.5 0.8 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78540.1 - 2.7e-10 40.0 0.1 9.3e-10 38.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1769 PF08588.10 EFA78540.1 - 4.8e-06 26.7 16.1 1.2 9.4 0.0 9.0 6 2 3 10 10 10 2 Protein of unknown function (DUF1769) APH PF01636.23 EFA78540.1 - 0.26 11.2 0.0 0.38 10.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2457 PF10446.9 EFA78541.1 - 7.8e-05 22.0 16.9 0.00012 21.4 16.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) CDC45 PF02724.14 EFA78541.1 - 9.1e-05 21.0 6.8 0.00013 20.5 6.8 1.2 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 EFA78541.1 - 0.00015 21.3 12.2 0.00021 20.9 12.2 1.1 1 0 0 1 1 1 1 SDA1 NOA36 PF06524.12 EFA78541.1 - 0.0016 17.8 16.8 0.003 16.9 16.8 1.6 1 0 0 1 1 1 1 NOA36 protein CobT PF06213.12 EFA78541.1 - 0.0027 17.1 13.5 0.0046 16.4 13.5 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Mpp10 PF04006.12 EFA78541.1 - 0.0059 15.1 13.9 0.0087 14.6 13.9 1.1 1 0 0 1 1 1 1 Mpp10 protein DUF295 PF03478.18 EFA78541.1 - 0.11 12.1 2.1 0.21 11.2 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF295) Sigma70_ner PF04546.13 EFA78541.1 - 0.15 12.0 15.6 0.17 11.8 13.5 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region PPP4R2 PF09184.11 EFA78541.1 - 0.15 11.7 16.8 0.27 10.8 16.8 1.4 1 0 0 1 1 1 0 PPP4R2 XAP5 PF04921.14 EFA78541.1 - 0.16 11.7 7.3 0.33 10.7 7.3 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator Nop14 PF04147.12 EFA78541.1 - 0.17 10.1 24.8 0.0064 14.8 18.6 1.6 2 0 0 2 2 2 0 Nop14-like family RRN3 PF05327.11 EFA78541.1 - 0.41 9.1 14.3 0.71 8.3 14.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4637 PF15470.6 EFA78541.1 - 0.6 9.8 15.1 1 9.1 15.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RPA43_OB PF17875.1 EFA78541.1 - 0.7 10.5 3.0 1.5 9.5 3.0 1.5 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Tim54 PF11711.8 EFA78541.1 - 0.77 8.5 3.4 1.1 7.9 3.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PTPRCAP PF15713.5 EFA78541.1 - 0.84 9.9 17.4 1.4 9.2 17.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TRAP_alpha PF03896.16 EFA78541.1 - 0.91 8.7 12.0 1.4 8.0 12.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_pol_Rpc4 PF05132.14 EFA78541.1 - 0.96 9.9 2.8 1.8 9.0 2.8 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 EFA78541.1 - 1.2 7.1 34.7 2 6.4 34.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi Utp14 PF04615.13 EFA78541.1 - 2.4 6.6 15.3 3.2 6.2 15.3 1.1 1 0 0 1 1 1 0 Utp14 protein TFB6 PF17110.5 EFA78541.1 - 5.1 6.8 10.3 9.6 5.9 10.3 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH BUD22 PF09073.10 EFA78541.1 - 5.5 6.2 19.2 8.8 5.5 19.2 1.2 1 0 0 1 1 1 0 BUD22 Radial_spoke PF04712.12 EFA78541.1 - 7.5 5.4 11.5 13 4.5 11.5 1.4 1 0 0 1 1 1 0 Radial spokehead-like protein YL1 PF05764.13 EFA78541.1 - 8.9 6.3 23.7 15 5.6 23.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Ank_2 PF12796.7 EFA78542.1 - 1.5e-29 102.4 10.9 1.2e-05 25.8 0.0 7.4 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78542.1 - 2.2e-24 85.5 12.8 9.1e-05 22.9 0.0 10.0 6 2 3 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78542.1 - 1.1e-22 79.8 9.9 0.0069 16.7 0.0 10.7 6 3 5 11 11 11 6 Ankyrin repeats (many copies) Archease PF01951.16 EFA78542.1 - 3e-21 76.1 5.6 3.2e-20 72.8 2.6 3.2 2 1 0 2 2 2 1 Archease protein family (MTH1598/TM1083) Ank_3 PF13606.6 EFA78542.1 - 3.4e-19 66.9 13.7 2.3 9.1 0.0 14.6 14 1 1 15 15 15 4 Ankyrin repeat DUF3447 PF11929.8 EFA78542.1 - 0.061 13.3 0.2 0.061 13.3 0.2 9.7 7 1 2 10 10 10 0 Domain of unknown function (DUF3447) Ank PF00023.30 EFA78542.1 - 0.43 11.1 4.7 41 4.8 0.0 6.2 8 2 0 8 8 8 0 Ankyrin repeat Pkinase PF00069.25 EFA78543.1 - 1.6e-73 247.3 0.0 5.3e-73 245.6 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain BRCA-2_OB1 PF09103.10 EFA78543.1 - 8.1e-36 122.7 4.4 8.4e-36 122.6 0.0 3.4 4 0 0 4 4 4 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Pkinase_Tyr PF07714.17 EFA78543.1 - 1.9e-33 115.9 0.0 3.6e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase BRCA-2_helical PF09169.10 EFA78543.1 - 6.4e-22 78.1 0.2 3e-20 72.7 0.2 3.2 1 1 0 1 1 1 1 BRCA2, helical Kinase-like PF14531.6 EFA78543.1 - 5.2e-05 22.7 0.0 0.00018 20.9 0.0 1.9 3 0 0 3 3 3 1 Kinase-like SIN1_PH PF16979.5 EFA78543.1 - 0.0028 17.9 0.4 0.014 15.7 0.4 2.2 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology RhoGEF PF00621.20 EFA78544.1 - 4.2e-42 144.5 7.9 4.2e-42 144.5 7.9 2.0 2 0 0 2 2 2 1 RhoGEF domain CH PF00307.31 EFA78544.1 - 3.8e-14 52.8 0.2 3.3e-13 49.8 0.0 2.7 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ_SEC7_PH PF16453.5 EFA78544.1 - 0.017 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 PH domain IQ PF00612.27 EFA78544.1 - 0.036 13.8 1.1 0.12 12.3 1.1 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif CPSase_L_D3 PF02787.19 EFA78544.1 - 0.098 13.0 2.5 0.49 10.8 0.0 3.1 3 0 0 3 3 3 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Usp PF00582.26 EFA78545.1 - 5.3e-18 65.9 0.0 6.6e-16 59.1 0.0 2.1 1 1 0 1 1 1 1 Universal stress protein family CorA PF01544.18 EFA78546.1 - 1.8e-34 119.4 1.3 1.8e-34 119.4 1.3 2.8 2 1 1 3 3 3 1 CorA-like Mg2+ transporter protein B277 PF17623.2 EFA78546.1 - 0.26 10.3 7.3 0.47 9.5 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function RhoGAP PF00620.27 EFA78547.1 - 4.9e-38 130.3 0.1 1.5e-37 128.8 0.1 1.9 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.20 EFA78547.1 - 1e-28 100.8 1.7 7.5e-27 94.7 0.0 3.0 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EFA78547.1 - 2.1e-26 92.5 4.0 4.1e-21 75.5 0.9 2.8 3 0 0 3 3 2 2 PH domain BAR_3 PF16746.5 EFA78547.1 - 2.2e-07 30.8 10.1 5.3e-07 29.6 10.1 1.6 1 0 0 1 1 1 1 BAR domain of APPL family PH_11 PF15413.6 EFA78547.1 - 5.6e-05 23.5 2.8 0.00034 21.0 2.8 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.6 EFA78547.1 - 0.00043 20.5 0.2 1.5 9.1 0.0 2.7 2 0 0 2 2 2 2 Pleckstrin homology domain IMD PF08397.11 EFA78547.1 - 0.013 14.9 5.7 0.064 12.6 0.4 2.5 2 0 0 2 2 2 0 IRSp53/MIM homology domain PH_6 PF15406.6 EFA78547.1 - 0.038 14.3 0.0 0.096 13.0 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 EFA78547.1 - 0.12 12.8 1.9 3.8 7.9 1.0 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain DUF1664 PF07889.12 EFA78547.1 - 0.25 11.4 1.5 1.2 9.2 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Med11 PF10280.9 EFA78547.1 - 0.34 11.4 4.2 1.3 9.5 4.2 2.0 1 0 0 1 1 1 0 Mediator complex protein NUSAP PF16006.5 EFA78548.1 - 0.0034 17.2 30.4 0.0034 17.2 30.4 4.4 1 1 3 4 4 4 1 Nucleolar and spindle-associated protein GST_C_3 PF14497.6 EFA78549.1 - 5.3e-19 68.3 0.3 9.3e-19 67.5 0.3 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA78549.1 - 3.9e-10 39.9 0.0 1.3e-09 38.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA78549.1 - 4.3e-05 23.7 0.1 6.9e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA78549.1 - 0.00014 21.8 0.0 0.00029 20.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA78549.1 - 0.044 13.6 0.1 0.09 12.6 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Casc1_N PF15927.5 EFA78551.1 - 0.076 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus VacA2 PF03077.14 EFA78551.1 - 0.2 11.5 0.1 0.2 11.5 0.1 2.4 3 0 0 3 3 3 0 Putative vacuolating cytotoxin Snapin_Pallidin PF14712.6 EFA78552.1 - 4e-22 78.4 0.6 4e-22 78.4 0.6 2.3 3 0 0 3 3 3 1 Snapin/Pallidin Syntaxin PF00804.25 EFA78552.1 - 0.00091 19.0 2.5 0.00091 19.0 2.5 2.3 3 0 0 3 3 3 1 Syntaxin DUF489 PF04356.12 EFA78552.1 - 0.0053 16.8 0.5 0.0053 16.8 0.5 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF489) DUF4820 PF16091.5 EFA78552.1 - 0.006 16.0 6.7 0.006 16.0 6.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4820) CheW PF01584.19 EFA78552.1 - 0.048 13.3 0.2 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 CheW-like domain VPS11_C PF12451.8 EFA78552.1 - 1.6 9.0 4.8 0.7 10.2 0.7 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal NifU_N PF01592.16 EFA78553.1 - 2.5e-53 179.6 0.1 3.1e-53 179.3 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain ACOX PF01756.19 EFA78555.1 - 1.5e-06 27.9 0.2 2.6e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase SdrD_B PF17210.3 EFA78556.1 - 3.6e-43 146.3 21.8 1.8e-10 41.0 0.7 6.3 6 0 0 6 6 6 5 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA78556.1 - 3.2e-17 62.6 8.1 0.0021 18.3 0.3 5.5 5 0 0 5 5 5 5 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA78556.1 - 6e-12 45.7 5.0 0.006 16.9 0.2 5.3 5 0 0 5 5 5 4 Prealbumin-like fold domain DUF2012 PF09430.10 EFA78556.1 - 1.3e-07 31.8 0.3 0.2 11.8 0.0 4.4 5 0 0 5 5 5 2 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 EFA78556.1 - 1.3e-06 28.3 8.6 6.6 6.8 0.0 6.1 6 0 0 6 6 6 3 CarboxypepD_reg-like domain MetallophosN PF16371.5 EFA78556.1 - 2e-05 24.8 2.8 0.1 12.9 0.1 4.6 5 0 0 5 5 5 2 N terminal of Calcineurin-like phosphoesterase bMG3 PF11974.8 EFA78556.1 - 0.0003 20.7 0.0 20 5.3 0.0 4.7 5 0 0 5 5 5 0 Bacterial alpha-2-macroglobulin MG3 domain Y_Y_Y PF07495.13 EFA78556.1 - 0.0064 16.4 0.2 0.12 12.3 0.1 2.9 3 0 0 3 3 3 1 Y_Y_Y domain RET_CLD4 PF17813.1 EFA78556.1 - 0.036 14.3 0.1 0.084 13.2 0.1 1.6 1 0 0 1 1 1 0 RET Cadherin like domain 4 Big_6 PF17936.1 EFA78556.1 - 0.037 14.3 0.7 13 6.2 0.1 4.1 4 0 0 4 4 4 0 Bacterial Ig domain DUF1107 PF06526.12 EFA78558.1 - 0.13 12.2 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1107) Glyco_hydro_20 PF00728.22 EFA78559.1 - 3e-76 257.1 0.1 3.8e-76 256.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFA78559.1 - 2.5e-13 50.9 0.1 1.3e-11 45.3 0.1 2.4 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Peptidase_M8 PF01457.16 EFA78560.1 - 7.4e-54 183.3 0.5 1.2e-53 182.7 0.5 1.3 1 0 0 1 1 1 1 Leishmanolysin TLD PF07534.16 EFA78561.1 - 5.1e-36 124.0 2.2 5.1e-36 124.0 2.2 2.5 2 1 0 2 2 2 1 TLD GRAM PF02893.20 EFA78561.1 - 9.4e-05 22.3 0.3 0.00023 21.0 0.1 1.8 2 0 0 2 2 2 1 GRAM domain WD40 PF00400.32 EFA78562.1 - 3.6e-13 49.7 26.9 0.00081 20.2 0.5 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78562.1 - 5.1e-06 26.7 5.1 0.27 11.5 0.1 4.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain LysM PF01476.20 EFA78562.1 - 0.0031 17.5 0.1 0.016 15.3 0.0 2.4 2 0 0 2 2 2 1 LysM domain Phytase PF02333.15 EFA78562.1 - 0.1 11.5 0.1 0.21 10.5 0.1 1.5 1 0 0 1 1 1 0 Phytase NIF PF03031.18 EFA78563.1 - 1e-52 178.1 0.5 2e-52 177.1 0.5 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SwrA PF17423.2 EFA78563.1 - 0.033 14.2 0.9 0.079 12.9 0.9 1.7 1 0 0 1 1 1 0 Swarming motility protein eIF-6 PF01912.18 EFA78564.1 - 6.3e-79 264.0 0.1 1.3e-78 263.0 0.1 1.4 2 0 0 2 2 2 1 eIF-6 family CH PF00307.31 EFA78565.1 - 3.1e-16 59.5 0.1 1.8e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain RA PF00788.23 EFA78565.1 - 1.2e-12 48.3 0.1 8.8e-06 26.3 0.0 2.9 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain PH PF00169.29 EFA78565.1 - 9.4e-08 32.5 0.0 4.1e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 PH domain Ras_bdg_2 PF14847.6 EFA78565.1 - 0.00069 19.9 0.9 0.25 11.7 0.0 3.1 3 0 0 3 3 3 2 Ras-binding domain of Byr2 CH_2 PF06294.11 EFA78565.1 - 0.0021 18.1 0.0 0.18 11.9 0.0 2.6 2 0 0 2 2 2 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFA78565.1 - 0.0031 17.3 0.2 0.25 11.2 0.1 2.5 2 0 0 2 2 2 1 CAMSAP CH domain Presenilin PF01080.17 EFA78565.1 - 0.0041 15.9 0.9 0.0041 15.9 0.9 3.6 1 1 1 2 2 2 1 Presenilin PQ-loop PF04193.14 EFA78566.1 - 4.6e-21 74.3 8.4 2.2e-13 49.8 1.8 2.5 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EFA78566.1 - 1.8 9.3 8.9 4.2 8.2 0.1 2.9 2 1 1 3 3 3 0 ER lumen protein retaining receptor Adeno_E3_CR2 PF02439.15 EFA78566.1 - 4.2 7.2 7.6 11 5.9 0.2 2.6 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 zf-met PF12874.7 EFA78567.1 - 5.4e-07 29.8 2.2 1.6e-06 28.3 2.2 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFA78567.1 - 1.2e-06 28.6 1.9 4.4e-06 26.8 1.9 2.1 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFA78567.1 - 0.00026 21.3 0.9 0.0013 19.1 0.9 2.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EFA78567.1 - 0.00053 19.9 0.8 0.0015 18.5 0.8 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EFA78567.1 - 0.04 14.4 1.4 0.13 12.8 1.4 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFA78567.1 - 0.042 14.7 0.4 0.13 13.2 0.4 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-DBF PF07535.12 EFA78567.1 - 0.64 10.2 3.5 2.9 8.1 1.7 2.6 2 0 0 2 2 2 0 DBF zinc finger DUF3439 PF11921.8 EFA78567.1 - 3.3 7.7 6.4 0.29 11.1 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Tweety PF04906.13 EFA78568.1 - 5.4e-06 25.3 7.1 0.00033 19.4 7.1 2.4 1 1 0 1 1 1 1 Tweety DUF1772 PF08592.11 EFA78568.1 - 0.087 13.1 1.2 1.1 9.5 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF2207 PF09972.9 EFA78568.1 - 3.5 6.3 10.9 1.5 7.5 1.1 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) 4HB_MCP_1 PF12729.7 EFA78568.1 - 7.6 6.0 6.6 17 4.9 0.3 2.9 3 1 0 3 3 3 0 Four helix bundle sensory module for signal transduction CAAD PF14159.6 EFA78568.1 - 9.4 6.1 7.3 1.8 8.4 2.0 2.5 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase ABC2_membrane_2 PF12679.7 EFA78568.1 - 9.7 5.4 10.6 0.55 9.5 4.0 2.2 3 0 0 3 3 3 0 ABC-2 family transporter protein Kelch_6 PF13964.6 EFA78570.1 - 5.6e-05 23.3 4.8 0.00086 19.5 0.5 3.9 3 1 1 4 4 4 1 Kelch motif Kelch_1 PF01344.25 EFA78570.1 - 0.024 14.2 1.5 0.11 12.0 0.2 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 EFA78570.1 - 0.05 13.9 4.1 0.27 11.6 0.0 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain Nop14 PF04147.12 EFA78571.1 - 0.39 8.9 15.2 0.4 8.9 15.2 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 EFA78571.1 - 0.92 8.6 19.4 1.1 8.3 19.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 EFA78571.1 - 0.95 7.7 10.0 1 7.6 10.0 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EFA78571.1 - 1.2 8.5 16.6 1.3 8.3 16.6 1.2 1 0 0 1 1 1 0 SDA1 NESP55 PF06390.12 EFA78571.1 - 1.9 8.0 14.4 2.6 7.6 14.4 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) BUD22 PF09073.10 EFA78571.1 - 3.9 6.7 16.3 4.6 6.5 16.3 1.1 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 EFA78571.1 - 6.9 5.8 8.1 8.9 5.4 8.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter zf-C2H2 PF00096.26 EFA78572.1 - 2.7e-10 40.1 11.6 0.00029 21.1 1.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFA78572.1 - 1.2e-09 38.1 11.6 0.00035 21.2 1.1 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFA78572.1 - 0.00013 21.9 0.3 0.00013 21.9 0.3 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFA78572.1 - 0.0029 18.0 9.6 0.024 15.1 1.5 4.1 4 0 0 4 4 4 1 Zinc-finger double domain zf_Hakai PF18408.1 EFA78572.1 - 0.01 15.5 0.1 0.04 13.6 0.1 1.9 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-C2H2_2 PF12756.7 EFA78572.1 - 0.017 15.5 2.7 2.6 8.4 0.3 2.7 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFA78572.1 - 0.018 15.4 0.4 0.018 15.4 0.4 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.12 EFA78572.1 - 0.099 13.4 1.8 4.2 8.2 0.4 2.6 2 0 0 2 2 2 0 CHORD zf-H2C2_5 PF13909.6 EFA78572.1 - 0.11 12.3 8.7 2.9 7.7 0.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_aberr PF17017.5 EFA78572.1 - 0.14 12.3 5.4 0.24 11.5 0.6 2.7 2 1 1 3 3 3 0 Aberrant zinc-finger zf-met PF12874.7 EFA78572.1 - 0.19 12.2 3.7 56 4.3 0.0 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Thioredoxin PF00085.20 EFA78573.1 - 2.3e-27 95.0 0.6 1.2e-19 70.2 0.1 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EFA78573.1 - 1.8e-06 28.3 0.4 1.8e-05 25.1 0.1 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFA78573.1 - 0.00024 21.4 1.1 0.52 10.7 0.3 3.3 2 1 1 3 3 3 1 Thioredoxin-like RanGAP1_C PF07834.11 EFA78573.1 - 0.046 13.3 0.2 0.092 12.4 0.2 1.4 1 1 0 1 1 1 0 RanGAP1 C-terminal domain DIM1 PF02966.16 EFA78573.1 - 0.079 12.7 0.6 0.24 11.2 0.2 2.0 2 0 0 2 2 2 0 Mitosis protein DIM1 RNA_POL_M_15KD PF02150.16 EFA78575.1 - 7.4e-07 28.9 2.9 7.4e-07 28.9 2.9 2.4 2 1 1 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EFA78575.1 - 0.0028 17.5 4.9 0.0046 16.8 0.1 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 EFA78575.1 - 0.0091 15.9 1.4 0.16 12.0 0.1 2.3 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zf-IS66 PF13005.7 EFA78575.1 - 0.07 13.5 2.6 9.3 6.7 0.1 2.9 2 1 1 3 3 3 0 zinc-finger binding domain of transposase IS66 Lar_restr_allev PF14354.6 EFA78575.1 - 0.29 11.6 3.8 0.51 10.8 0.0 2.5 2 1 0 2 2 2 0 Restriction alleviation protein Lar TF_Zn_Ribbon PF08271.12 EFA78575.1 - 4.8 6.8 6.8 1.6 8.3 0.1 3.3 4 1 0 4 4 4 0 TFIIB zinc-binding zf-ACC PF17848.1 EFA78575.1 - 5.2 7.2 8.0 15 5.8 1.1 3.1 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Pet191_N PF10203.9 EFA78576.1 - 0.001 19.3 2.8 0.001 19.3 2.8 1.8 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EFA78576.1 - 0.0017 18.3 2.7 0.76 9.8 0.3 2.7 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like MTCP1 PF08991.10 EFA78577.1 - 0.0012 19.1 1.9 0.0012 19.1 1.9 2.2 2 1 0 2 2 2 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EFA78577.1 - 0.0093 16.1 0.8 0.0093 16.1 0.8 2.4 3 0 0 3 3 3 1 CHCH domain Biopterin_H PF00351.21 EFA78578.1 - 2.3e-168 559.4 0.0 2.8e-168 559.1 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EFA78578.1 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 EFA78578.1 - 0.024 15.2 0.0 0.061 13.9 0.0 1.6 1 0 0 1 1 1 0 ACT domain RasGAP PF00616.19 EFA78579.1 - 2.7e-57 193.8 0.1 2.7e-57 193.8 0.1 2.2 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFA78579.1 - 3.9e-32 111.2 6.1 3.9e-32 111.2 6.1 2.2 2 0 0 2 2 2 1 RasGAP C-terminus YabA PF06156.13 EFA78579.1 - 0.03 15.0 1.2 0.03 15.0 1.2 3.1 2 1 1 3 3 3 0 Initiation control protein YabA AATF-Che1 PF13339.6 EFA78579.1 - 9.2 6.9 8.6 0.55 10.9 2.1 2.4 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor CBFD_NFYB_HMF PF00808.23 EFA78581.1 - 4.3e-17 62.1 0.9 8.4e-17 61.2 0.9 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFA78581.1 - 3.9e-12 46.7 0.2 3.9e-12 46.7 0.2 3.4 4 0 0 4 4 4 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 EFA78581.1 - 7.2 6.5 84.0 0.047 13.7 8.9 3.3 1 1 2 3 3 3 0 Transcription factor IIA, alpha/beta subunit ThiF PF00899.21 EFA78582.1 - 5.5e-28 97.9 0.1 8.2e-28 97.4 0.1 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EFA78582.1 - 0.012 15.9 0.1 0.021 15.1 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EFA78582.1 - 0.015 15.8 0.1 0.03 14.7 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 EFA78582.1 - 0.03 14.0 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EFA78582.1 - 0.045 14.0 0.2 0.078 13.2 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EFA78582.1 - 0.093 12.3 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 EFA78582.1 - 0.2 10.8 0.2 0.29 10.3 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Cullin PF00888.22 EFA78583.1 - 4.8e-155 517.6 29.5 4.8e-155 517.6 29.5 1.5 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFA78583.1 - 1.8e-27 95.1 7.5 3.2e-26 91.1 4.2 3.0 2 0 0 2 2 2 1 Cullin protein neddylation domain TFIIE_alpha PF02002.17 EFA78583.1 - 0.0012 18.6 0.1 0.006 16.4 0.1 2.3 1 0 0 1 1 1 1 TFIIE alpha subunit TrmB PF01978.19 EFA78583.1 - 0.0091 15.9 0.1 7.8 6.5 0.0 2.9 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB Rio2_N PF09202.11 EFA78583.1 - 0.011 15.9 1.3 0.11 12.8 0.0 3.0 3 0 0 3 3 3 0 Rio2, N-terminal IL28A PF15177.6 EFA78583.1 - 0.015 15.1 0.0 0.051 13.4 0.0 1.9 1 0 0 1 1 1 0 Interleukin-28A MFS_1 PF07690.16 EFA78584.1 - 4.7e-32 111.3 20.3 2.7e-23 82.5 5.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA78584.1 - 2.4e-12 46.5 3.2 2.4e-12 46.5 3.2 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter Amino_oxidase PF01593.24 EFA78585.1 - 3.1e-64 218.0 0.0 3.5e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA78585.1 - 3.3e-14 52.9 0.1 9.1e-14 51.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFA78585.1 - 4.3e-06 26.4 0.6 8.2e-06 25.4 0.5 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFA78585.1 - 2.3e-05 23.3 0.3 0.00034 19.4 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EFA78585.1 - 2.4e-05 23.6 1.1 4.1e-05 22.9 0.7 1.5 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EFA78585.1 - 0.00016 20.8 0.1 0.14 11.2 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein DAO PF01266.24 EFA78585.1 - 0.00034 20.3 0.1 0.00072 19.2 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFA78585.1 - 0.00061 19.1 0.2 0.0011 18.2 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EFA78585.1 - 0.0014 19.1 0.5 0.013 16.0 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA78585.1 - 0.0045 16.3 0.1 0.05 12.8 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFA78585.1 - 0.012 14.8 0.4 0.022 14.0 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 EFA78585.1 - 0.024 14.0 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GDI PF00996.18 EFA78585.1 - 0.028 12.9 0.0 0.047 12.2 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor PP2C PF00481.21 EFA78586.1 - 7.3e-60 202.8 0.0 7.3e-60 202.8 0.0 2.6 2 1 0 2 2 2 1 Protein phosphatase 2C Pyrophosphatase PF00719.19 EFA78587.1 - 5.5e-47 159.6 0.8 6.8e-47 159.2 0.8 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase TFIIF_alpha PF05793.12 EFA78588.1 - 3.9e-28 98.4 70.6 6.1e-27 94.4 70.6 2.2 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) OTU PF02338.19 EFA78589.1 - 5.6e-22 78.6 4.1 2.5e-21 76.5 0.0 3.0 2 2 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFA78589.1 - 5.3e-10 39.2 5.4 4.4e-09 36.2 0.1 3.2 1 1 0 2 2 2 1 Peptidase C65 Otubain BSP_II PF05432.11 EFA78589.1 - 0.004 16.9 21.3 0.004 16.9 21.3 1.6 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) CDC45 PF02724.14 EFA78589.1 - 0.12 10.7 17.2 0.16 10.2 17.2 1.3 1 0 0 1 1 1 0 CDC45-like protein GRAM PF02893.20 EFA78590.1 - 2.8e-13 49.7 1.0 8.7e-08 32.1 0.2 2.7 2 0 0 2 2 2 2 GRAM domain Ras PF00071.22 EFA78591.1 - 2e-19 69.8 0.7 7.1e-09 35.5 0.3 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFA78591.1 - 6e-11 42.6 0.3 2.3e-07 31.0 0.0 3.1 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78591.1 - 1.7e-06 27.6 0.1 0.046 13.2 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_28 PF13521.6 EFA78591.1 - 0.048 13.9 0.0 0.099 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFA78591.1 - 0.073 13.1 0.1 3.8 7.6 0.1 3.2 1 1 0 1 1 1 0 AAA domain Peptidase_C1 PF00112.23 EFA78592.1 - 8.7e-80 267.9 6.0 1.1e-79 267.5 6.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA78592.1 - 1.4e-11 44.6 1.4 2.7e-11 43.7 1.4 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA78592.1 - 0.0022 16.9 2.8 0.077 11.7 0.7 2.2 2 0 0 2 2 2 2 Peptidase C1-like family RPAP3_C PF13877.6 EFA78593.1 - 0.092 13.3 2.4 13 6.4 0.1 2.9 2 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 Acp26Ab PF05777.12 EFA78593.1 - 0.11 13.1 0.0 0.33 11.6 0.0 1.8 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) Med9 PF07544.13 EFA78594.1 - 9.9e-10 38.4 2.2 9.9e-10 38.4 2.2 2.2 2 1 1 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 Pentapeptide PF00805.22 EFA78595.1 - 2.1e-21 75.2 32.4 4.3e-13 48.6 1.1 5.9 4 2 1 6 6 6 5 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 EFA78595.1 - 1.6e-16 60.4 0.3 7.6e-16 58.2 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain Pentapeptide_4 PF13599.6 EFA78595.1 - 2.9e-10 40.2 22.2 2e-06 27.8 5.6 4.2 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFA78595.1 - 3.7e-10 39.8 16.4 1.3e-05 25.2 1.1 4.7 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) CfAFP PF05264.11 EFA78595.1 - 0.00076 19.5 7.1 0.00076 19.5 7.1 2.8 3 1 0 3 3 3 1 Choristoneura fumiferana antifreeze protein (CfAFP) TIG PF01833.24 EFA78596.1 - 0.0034 17.4 5.0 0.0034 17.4 5.0 4.6 3 1 1 4 4 4 2 IPT/TIG domain EGF_2 PF07974.13 EFA78596.1 - 0.0043 17.4 12.8 0.0089 16.4 12.8 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA78596.1 - 0.023 14.7 7.4 0.049 13.7 7.4 1.5 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 EFA78596.1 - 0.053 14.2 6.0 0.16 12.7 6.0 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF EB PF01683.18 EFA78596.1 - 0.057 13.7 6.6 0.023 15.0 3.7 1.8 2 0 0 2 2 2 0 EB module EGF PF00008.27 EFA78596.1 - 5.3 7.4 10.4 12 6.3 10.4 1.6 1 0 0 1 1 1 0 EGF-like domain DUF4448 PF14610.6 EFA78597.1 - 8e-05 22.5 1.3 0.011 15.6 0.1 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF4448) EGF_2 PF07974.13 EFA78597.1 - 0.00011 22.5 35.1 0.031 14.6 12.8 2.5 2 0 0 2 2 2 2 EGF-like domain EB PF01683.18 EFA78597.1 - 0.00082 19.6 17.2 0.035 14.4 2.9 2.7 2 0 0 2 2 2 2 EB module Mvb12 PF09452.10 EFA78597.1 - 0.0041 17.5 0.1 3 8.3 0.0 2.7 2 0 0 2 2 2 2 ESCRT-I subunit Mvb12 EGF_Tenascin PF18720.1 EFA78597.1 - 1.3 9.2 19.9 0.69 10.0 7.0 2.6 2 0 0 2 2 2 0 Tenascin EGF domain hEGF PF12661.7 EFA78597.1 - 4.2 8.1 25.4 11 6.9 7.5 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF Sec7 PF01369.20 EFA78598.1 - 1.1e-56 191.5 0.9 3.6e-56 189.8 0.9 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EFA78598.1 - 5e-34 117.5 1.6 5e-34 117.5 1.6 4.2 6 0 0 6 6 6 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EFA78598.1 - 6.4e-23 80.4 7.7 1.7e-22 79.1 0.2 4.5 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) CLAMP PF14769.6 EFA78598.1 - 0.082 13.4 0.2 2.1 8.9 0.2 3.2 3 0 0 3 3 3 0 Flagellar C1a complex subunit C1a-32 TPR_1 PF00515.28 EFA78599.1 - 1.7e-17 62.4 9.8 2e-05 24.2 0.0 7.9 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78599.1 - 1.7e-16 59.0 9.9 0.0009 19.2 0.0 9.0 11 0 0 11 11 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFA78599.1 - 4.1e-13 49.6 17.1 0.015 15.8 0.0 8.1 7 2 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78599.1 - 4.3e-13 48.9 11.1 0.0038 17.9 0.0 8.5 4 1 5 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78599.1 - 2.7e-11 43.6 10.0 1.9 8.8 0.1 7.4 4 1 3 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78599.1 - 4.9e-11 41.9 16.8 0.0059 16.7 0.1 8.5 8 1 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78599.1 - 3.6e-09 36.2 9.9 0.00028 20.5 0.1 5.6 5 1 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 EFA78599.1 - 4.1e-08 32.7 8.6 1.2 9.3 0.1 6.7 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFA78599.1 - 4.5e-06 26.7 3.7 0.00026 21.1 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA78599.1 - 4.7e-06 27.1 5.1 0.63 10.7 0.1 5.7 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 EFA78599.1 - 0.00058 19.6 4.2 0.012 15.3 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat-like domain DUF627 PF04781.12 EFA78599.1 - 0.0095 15.9 7.9 1.2 9.1 0.1 3.8 4 0 0 4 4 4 2 Protein of unknown function (DUF627) ANAPC3 PF12895.7 EFA78599.1 - 0.029 14.6 0.3 0.029 14.6 0.3 5.8 5 2 1 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 EFA78599.1 - 0.064 13.0 4.2 2.2 8.0 0.1 3.2 4 0 0 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 SHNi-TPR PF10516.9 EFA78599.1 - 0.068 12.6 0.8 20 4.7 0.1 3.2 3 0 0 3 3 3 0 SHNi-TPR DUF3338 PF11819.8 EFA78599.1 - 0.079 12.9 3.6 3.1 7.8 0.9 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3338) TPR_20 PF14561.6 EFA78599.1 - 0.1 13.0 7.2 0.6 10.5 0.6 4.2 4 1 2 6 6 4 0 Tetratricopeptide repeat PAD PF03068.15 EFA78599.1 - 0.11 11.5 1.0 2.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) Fis1_TPR_C PF14853.6 EFA78599.1 - 0.61 10.2 6.9 17 5.6 0.1 4.6 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFA78599.1 - 1.6 8.9 11.8 0.69 10.0 0.2 4.5 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain PRKCSH_1 PF13015.6 EFA78600.1 - 2.8e-06 27.1 2.1 1.8e-05 24.5 0.2 2.8 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein EGF_2 PF07974.13 EFA78600.1 - 3.1e-05 24.3 15.1 0.00012 22.4 15.1 2.1 1 0 0 1 1 1 1 EGF-like domain TIG PF01833.24 EFA78600.1 - 0.00043 20.3 12.9 0.0021 18.1 2.3 3.6 3 0 0 3 3 3 2 IPT/TIG domain EGF_Tenascin PF18720.1 EFA78600.1 - 0.53 10.4 4.9 1.7 8.7 4.9 1.9 1 0 0 1 1 1 0 Tenascin EGF domain Laminin_EGF PF00053.24 EFA78600.1 - 6.7 6.9 21.3 0.028 14.5 10.6 2.6 3 0 0 3 3 3 0 Laminin EGF domain Carbpep_Y_N PF05388.11 EFA78601.1 - 0.034 14.7 1.5 0.065 13.8 0.5 1.9 2 0 0 2 2 2 0 Carboxypeptidase Y pro-peptide DUF3298 PF11738.8 EFA78601.1 - 0.037 15.0 1.6 4 8.5 0.8 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3298) PBP PF01161.20 EFA78602.1 - 7.8e-24 84.5 0.0 1e-23 84.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein CHB_HEX_C_1 PF13290.6 EFA78604.1 - 2.6e-06 27.3 24.2 0.00015 21.7 0.4 6.0 5 0 0 5 5 5 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 EFA78604.1 - 3.6e-05 23.8 15.7 0.032 14.4 0.0 5.8 5 0 0 5 5 5 2 Fn3 associated Ephrin_rec_like PF07699.13 EFA78604.1 - 0.00033 20.4 1.6 0.00033 20.4 1.6 3.5 4 1 1 5 5 5 1 Putative ephrin-receptor like Laminin_G_3 PF13385.6 EFA78604.1 - 0.0086 16.2 0.0 0.029 14.5 0.0 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CHB_HEX_C PF03174.13 EFA78604.1 - 0.03 14.3 0.1 0.1 12.6 0.0 2.0 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain DUF1216 PF06746.11 EFA78604.1 - 1.9 8.5 5.8 4.1 7.4 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1216) Porin_3 PF01459.22 EFA78606.1 - 2.5e-17 63.2 1.0 3.5e-17 62.8 1.0 1.2 1 0 0 1 1 1 1 Eukaryotic porin MDM10 PF12519.8 EFA78606.1 - 8e-05 21.7 4.1 9.4e-05 21.5 1.6 2.2 1 1 1 2 2 2 1 Mitochondrial distribution and morphology protein 10 PGM_PMM_I PF02878.16 EFA78607.1 - 3.1e-37 127.3 0.3 4.6e-37 126.8 0.3 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EFA78607.1 - 4.9e-27 94.4 0.0 1.1e-26 93.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EFA78607.1 - 2.5e-13 50.5 0.0 6.3e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EFA78607.1 - 6.6e-06 26.2 0.0 1.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF1882 PF08966.11 EFA78607.1 - 0.027 14.7 0.8 1.9 8.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) Band_7 PF01145.25 EFA78608.1 - 2.2e-24 86.4 0.4 3.3e-24 85.8 0.4 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EFA78608.1 - 8.5e-05 21.8 0.4 0.00011 21.4 0.4 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial Med2 PF11214.8 EFA78608.1 - 0.087 13.0 0.7 0.15 12.2 0.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 NDUF_B7 PF05676.13 EFA78609.1 - 1.1e-27 95.6 2.7 1.5e-27 95.1 2.7 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Exo70 PF03081.15 EFA78610.1 - 2.3e-05 23.6 0.1 2.5e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Exo70 exocyst complex subunit RcbX PF02341.15 EFA78610.1 - 0.053 13.8 0.0 0.077 13.3 0.0 1.3 1 0 0 1 1 1 0 RbcX protein Fe_hyd_lg_C PF02906.14 EFA78611.1 - 7.4e-61 205.9 0.0 1.7e-57 194.9 0.0 2.5 2 1 0 2 2 2 1 Iron only hydrogenase large subunit, C-terminal domain Cation_efflux PF01545.21 EFA78612.1 - 5e-48 163.5 9.1 5e-48 163.5 9.1 3.4 4 1 0 4 4 4 1 Cation efflux family Rap_GAP PF02145.15 EFA78613.1 - 7.7e-62 208.2 0.2 2.6e-61 206.4 0.0 2.1 2 0 0 2 2 2 1 Rap/ran-GAP PH PF00169.29 EFA78613.1 - 1.4e-29 102.7 15.6 1.8e-16 60.5 1.3 4.8 3 1 1 4 4 4 3 PH domain PH_11 PF15413.6 EFA78613.1 - 6.7e-07 29.7 26.9 0.0012 19.2 7.4 5.7 3 1 1 4 4 4 2 Pleckstrin homology domain PH_6 PF15406.6 EFA78613.1 - 1.4e-06 28.5 0.0 1.8e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_10 PF15411.6 EFA78613.1 - 0.00034 20.9 3.6 0.00037 20.8 0.3 2.9 2 1 1 3 3 3 1 Pleckstrin homology domain PH_9 PF15410.6 EFA78613.1 - 0.0017 18.7 3.5 0.0027 18.1 1.2 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EFA78613.1 - 0.0019 18.5 4.2 1.6 9.0 0.1 3.4 2 1 1 3 3 3 2 Pleckstrin homology domain PH_2 PF08458.10 EFA78613.1 - 0.048 14.0 1.4 19 5.7 0.0 3.3 3 0 0 3 3 3 0 Plant pleckstrin homology-like region DUF3439 PF11921.8 EFA78613.1 - 6.6 6.7 16.1 0.013 15.5 3.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) PEPCK_ATP PF01293.20 EFA78617.1 - 2.7e-221 735.2 0.0 3.1e-221 735.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase UPF0524 PF15823.5 EFA78617.1 - 0.081 12.3 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 UPF0524 of C3orf70 AAA_33 PF13671.6 EFA78617.1 - 0.17 12.1 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain SH3_9 PF14604.6 EFA78618.1 - 2.1e-25 88.3 0.8 1e-12 47.7 0.3 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EFA78618.1 - 9.9e-24 82.7 0.7 3.5e-15 55.3 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EFA78618.1 - 5.3e-20 70.9 0.3 1.2e-09 37.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EFA78618.1 - 2e-08 34.4 0.2 1.2e-07 31.9 0.1 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain BORCS6 PF10157.9 EFA78619.1 - 5.8e-08 33.1 8.1 5.8e-08 33.1 8.1 2.5 2 1 0 2 2 2 1 BLOC-1-related complex sub-unit 6 MatE PF01554.18 EFA78620.1 - 5.7e-64 214.6 38.0 3e-33 114.7 9.4 3.0 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 EFA78620.1 - 1.5e-06 28.3 17.7 7.3e-06 26.1 7.8 4.2 4 0 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain DWNN PF08783.11 EFA78620.1 - 0.053 13.8 0.3 0.11 12.8 0.3 1.6 1 0 0 1 1 1 0 DWNN domain FAM176 PF14851.6 EFA78620.1 - 0.053 13.2 2.7 0.066 12.9 1.4 1.8 1 1 0 1 1 1 0 FAM176 family Ribonuclease_3 PF00636.26 EFA78621.1 - 0.0057 17.3 0.3 0.027 15.1 0.0 2.2 2 1 0 2 2 2 1 Ribonuclease III domain DUF2034 PF10356.9 EFA78621.1 - 0.014 14.9 0.5 0.031 13.7 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) PRKCSH_1 PF13015.6 EFA78622.1 - 1.6e-07 31.2 0.1 2.9e-07 30.3 0.1 1.5 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA78622.1 - 0.0082 16.2 6.8 0.029 14.5 1.5 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Helicase_C PF00271.31 EFA78623.1 - 4.5e-21 75.3 0.1 1.9e-16 60.4 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 EFA78623.1 - 7e-19 68.3 1.4 2.7e-18 66.4 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EFA78623.1 - 1.9e-15 57.3 5.0 7.2e-15 55.5 5.0 2.1 1 0 0 1 1 1 1 RecQ zinc-binding HRDC PF00570.23 EFA78623.1 - 2.8e-13 49.6 0.2 3.3e-12 46.2 0.0 2.3 2 0 0 2 2 2 1 HRDC domain RQC PF09382.10 EFA78623.1 - 3.6e-13 49.3 0.3 9.7e-13 47.9 0.3 1.8 1 0 0 1 1 1 1 RQC domain APG6_N PF17675.1 EFA78623.1 - 0.084 13.4 3.8 0.22 12.0 3.8 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region FA_hydroxylase PF04116.13 EFA78624.1 - 7.9e-28 97.5 14.3 7.9e-28 97.5 14.3 2.3 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily NAD_binding_6 PF08030.12 EFA78625.1 - 5.9e-35 120.7 0.0 5.9e-35 120.7 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFA78625.1 - 3.2e-20 72.2 0.1 1.1e-19 70.5 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EFA78625.1 - 1.2e-09 38.3 16.5 1.8e-09 37.8 9.9 3.0 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EFA78625.1 - 0.0061 16.9 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Allexi_40kDa PF05549.11 EFA78625.1 - 0.0076 15.8 0.1 0.0076 15.8 0.1 2.0 2 0 0 2 2 2 1 Allexivirus 40kDa protein LPP20 PF02169.16 EFA78625.1 - 1 9.8 5.4 2.5 8.5 5.4 1.6 1 0 0 1 1 1 0 LPP20 lipoprotein G-alpha PF00503.20 EFA78626.1 - 6.4e-17 61.8 14.3 2e-15 56.8 9.8 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 EFA78626.1 - 0.057 12.9 0.1 2.1 7.7 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF1201 PF06716.11 EFA78627.1 - 0.04 13.9 0.1 0.048 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) Aminotran_5 PF00266.19 EFA78628.1 - 8.8e-35 120.3 0.0 1.7e-34 119.4 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V ATP_bind_3 PF01171.20 EFA78628.1 - 1.6e-15 57.3 0.0 4.5e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 PP-loop family Glyco_hydro_31 PF01055.26 EFA78629.1 - 4.1e-154 514.0 5.9 6.7e-154 513.3 5.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Prenyltrans PF00432.21 EFA78629.1 - 2e-45 152.2 8.3 2.4e-11 43.2 0.3 5.8 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat NtCtMGAM_N PF16863.5 EFA78629.1 - 1.1e-26 93.3 0.0 3.1e-26 91.9 0.0 1.8 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EFA78629.1 - 8.7e-11 42.0 0.3 8.7e-11 42.0 0.3 2.9 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 EFA78629.1 - 0.00081 19.6 0.3 0.0027 17.9 0.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Glyco_hydro_31 PF01055.26 EFA78630.1 - 1.5e-143 479.2 5.6 2.1e-143 478.7 5.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EFA78630.1 - 4.5e-23 81.6 0.0 1.1e-22 80.4 0.0 1.7 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EFA78630.1 - 4.4e-15 55.7 2.6 2.9e-14 53.1 0.6 3.2 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 EFA78630.1 - 0.0021 18.3 0.0 0.0052 17.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Histone PF00125.24 EFA78631.1 - 7.4e-13 49.0 4.3 5.3e-06 26.8 0.0 2.1 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EFA78631.1 - 0.0018 18.0 0.0 0.0068 16.1 0.0 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A F-box-like PF12937.7 EFA78632.1 - 0.032 14.1 0.3 0.19 11.6 0.0 2.5 3 0 0 3 3 3 0 F-box-like Ank_2 PF12796.7 EFA78633.1 - 0.015 15.8 0.2 0.072 13.7 0.1 2.3 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78633.1 - 0.094 13.3 0.1 4.1 8.1 0.0 3.0 2 1 1 3 3 3 0 Ankyrin repeats (many copies) HSP70 PF00012.20 EFA78634.1 - 1.4e-09 36.7 0.1 3.1e-09 35.6 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFA78634.1 - 0.022 13.6 0.0 0.06 12.2 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein TA0956 PF11513.8 EFA78634.1 - 0.071 13.3 2.0 0.48 10.7 0.1 3.2 3 0 0 3 3 3 0 Thermoplasma acidophilum protein TA0956 PPC PF04151.15 EFA78634.1 - 0.16 13.1 1.3 4.9 8.3 0.0 3.3 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain Ribosomal_L37ae PF01780.19 EFA78635.1 - 2.2e-41 139.8 9.2 2.5e-41 139.6 9.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EFA78635.1 - 0.00015 21.6 1.6 0.00023 21.0 1.6 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 EFA78635.1 - 0.015 15.7 0.3 0.58 10.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-RING_13 PF17977.1 EFA78635.1 - 0.033 14.3 2.1 0.047 13.8 2.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain OrfB_Zn_ribbon PF07282.11 EFA78635.1 - 0.047 13.6 1.4 0.064 13.2 1.4 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF1451 PF07295.11 EFA78635.1 - 0.049 13.7 0.5 0.065 13.3 0.5 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain C1_2 PF03107.16 EFA78635.1 - 0.062 13.6 3.0 1.1 9.6 3.3 2.0 1 1 0 1 1 1 0 C1 domain zf-Sec23_Sec24 PF04810.15 EFA78635.1 - 0.078 13.0 1.7 3.3 7.8 0.1 2.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-BED PF02892.15 EFA78635.1 - 0.1 12.6 4.7 2.8 8.0 0.5 2.2 1 1 1 2 2 2 0 BED zinc finger A2L_zn_ribbon PF08792.10 EFA78635.1 - 0.2 11.4 2.6 3.1 7.6 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn_ribbon_SprT PF17283.2 EFA78635.1 - 7.9 6.5 8.9 0.5 10.3 2.7 2.1 3 0 0 3 3 3 0 SprT-like zinc ribbon domain G-alpha PF00503.20 EFA78636.1 - 2.6e-23 82.8 8.8 2.6e-23 82.8 8.8 1.7 1 1 0 2 2 2 1 G-protein alpha subunit LRR_4 PF12799.7 EFA78637.1 - 8.2e-08 32.4 12.9 2.7e-05 24.4 5.8 2.7 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFA78637.1 - 1.4e-07 31.2 0.8 9.3e-05 22.0 0.7 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EFA78637.1 - 9.8e-05 22.1 14.7 0.00022 20.9 4.5 2.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EFA78637.1 - 0.93 9.7 6.9 6.8 7.0 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EFA78637.1 - 3.4 8.6 7.3 63 4.7 0.4 3.6 2 1 0 2 2 2 0 Leucine Rich Repeat UQ_con PF00179.26 EFA78638.1 - 3.7e-16 59.0 0.0 3.7e-16 59.0 0.0 2.3 2 1 1 3 3 2 1 Ubiquitin-conjugating enzyme BLM_N PF16202.5 EFA78638.1 - 0.00031 20.0 23.1 0.00042 19.6 23.1 1.1 1 0 0 1 1 1 1 N-terminal region of Bloom syndrome protein DUF3523 PF12037.8 EFA78638.1 - 0.021 14.2 20.2 0.036 13.4 20.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) zf-RanBP PF00641.18 EFA78638.1 - 0.044 13.1 1.2 0.044 13.1 1.2 1.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others DUF5523 PF17661.1 EFA78638.1 - 0.075 12.7 20.2 0.13 11.9 20.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF2052 PF09747.9 EFA78638.1 - 0.084 13.0 19.8 0.13 12.4 19.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Asp-B-Hydro_N PF05279.11 EFA78638.1 - 0.089 12.8 18.4 0.12 12.4 18.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CDC45 PF02724.14 EFA78638.1 - 0.13 10.5 16.7 0.16 10.2 16.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PAT1 PF09770.9 EFA78638.1 - 0.17 10.1 22.4 0.22 9.8 22.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 EFA78638.1 - 0.42 8.5 13.4 0.54 8.1 13.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NARP1 PF12569.8 EFA78638.1 - 0.46 9.3 14.5 0.58 9.0 14.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TFIIA PF03153.13 EFA78638.1 - 0.49 10.3 29.0 0.74 9.8 29.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Draxin PF15550.6 EFA78638.1 - 0.87 9.4 19.8 1.2 9.0 19.8 1.1 1 0 0 1 1 1 0 Draxin GREB1 PF15782.5 EFA78638.1 - 1.4 6.0 25.0 1.5 5.8 25.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 EFA78638.1 - 2 7.9 26.6 2.9 7.4 26.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SID-1_RNA_chan PF13965.6 EFA78638.1 - 2.8 6.3 11.7 3.5 5.9 11.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EMC3_TMCO1 PF01956.16 EFA78638.1 - 2.9 7.6 8.7 4.7 6.9 8.7 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like MMR1 PF08505.10 EFA78638.1 - 2.9 8.1 40.1 4.1 7.6 40.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF3446 PF11928.8 EFA78638.1 - 3.1 8.2 13.3 8.9 6.7 4.0 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain SMYLE_N PF18615.1 EFA78638.1 - 3.4 7.2 22.5 5 6.6 22.5 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Peptidase_S49_N PF08496.10 EFA78638.1 - 3.5 7.7 14.4 5.7 7.0 14.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Smg8_Smg9 PF10220.9 EFA78638.1 - 3.5 5.8 19.1 4.5 5.5 19.1 1.2 1 0 0 1 1 1 0 Smg8_Smg9 ALMT PF11744.8 EFA78638.1 - 3.5 6.3 22.2 5 5.8 22.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.15 EFA78638.1 - 3.7 6.4 13.8 5.8 5.7 13.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Connexin PF00029.19 EFA78638.1 - 4.1 7.1 13.2 7.1 6.3 13.2 1.4 1 0 0 1 1 1 0 Connexin CDC14 PF08045.11 EFA78638.1 - 4.2 6.4 16.1 3 6.9 14.6 1.6 1 1 0 1 1 1 0 Cell division control protein 14, SIN component Neur_chan_memb PF02932.16 EFA78638.1 - 4.3 7.3 14.4 9.3 6.2 14.4 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.9 EFA78638.1 - 4.6 5.7 32.3 5.7 5.4 32.3 1.0 1 0 0 1 1 1 0 Macoilin family Roughex PF06020.11 EFA78638.1 - 4.9 6.1 25.5 7.4 5.6 25.5 1.3 1 0 0 1 1 1 0 Drosophila roughex protein SelP_N PF04592.14 EFA78638.1 - 5.3 6.4 17.1 10 5.4 17.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Folate_carrier PF01770.18 EFA78638.1 - 5.6 5.6 9.4 9.6 4.8 9.4 1.3 1 0 0 1 1 1 0 Reduced folate carrier Androgen_recep PF02166.16 EFA78638.1 - 8.2 5.2 16.5 11 4.7 16.5 1.2 1 0 0 1 1 1 0 Androgen receptor Shisa PF13908.6 EFA78640.1 - 0.0051 17.1 0.3 0.0065 16.7 0.3 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator LapA_dom PF06305.11 EFA78640.1 - 0.0087 15.8 2.1 0.014 15.2 2.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain TMEM51 PF15345.6 EFA78640.1 - 0.019 14.8 4.0 0.064 13.1 4.0 1.6 1 1 0 1 1 1 0 Transmembrane protein 51 DUF2500 PF10694.9 EFA78640.1 - 0.025 15.1 0.1 0.037 14.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) V_ATPase_I PF01496.19 EFA78640.1 - 0.028 12.3 0.2 0.033 12.1 0.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family STT3 PF02516.14 EFA78640.1 - 0.042 12.8 0.1 0.048 12.6 0.1 1.1 1 0 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit Neurensin PF14927.6 EFA78640.1 - 0.046 13.4 0.1 0.067 12.9 0.1 1.3 1 0 0 1 1 1 0 Neurensin Serinc PF03348.15 EFA78640.1 - 0.08 11.9 0.1 0.1 11.5 0.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) EphA2_TM PF14575.6 EFA78640.1 - 0.12 13.3 0.3 0.23 12.4 0.3 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 EFA78640.1 - 0.12 13.4 5.7 0.23 12.4 5.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) NICE-3 PF07406.11 EFA78640.1 - 0.14 12.2 0.2 0.19 11.7 0.2 1.2 1 0 0 1 1 1 0 NICE-3 protein Vpu PF00558.19 EFA78640.1 - 0.15 11.9 0.7 0.25 11.2 0.7 1.3 1 0 0 1 1 1 0 Vpu protein DUF4381 PF14316.6 EFA78640.1 - 0.15 12.3 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF4525 PF15027.6 EFA78640.1 - 0.39 10.5 0.0 0.39 10.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) Ly49 PF08391.10 EFA78640.1 - 2.7 8.4 5.4 6.5 7.1 5.3 1.6 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region DAO PF01266.24 EFA78641.1 - 2.2e-47 162.3 0.0 4.6e-42 144.9 0.0 2.0 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA78641.1 - 6.2e-05 23.1 0.1 0.00013 22.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFA78641.1 - 0.0017 17.6 0.0 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Mqo PF06039.15 EFA78641.1 - 0.01 14.4 0.3 0.031 12.9 0.1 1.8 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) FAD_binding_3 PF01494.19 EFA78641.1 - 0.014 14.6 0.0 0.56 9.4 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 EFA78641.1 - 0.017 15.1 0.1 0.035 14.1 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFA78641.1 - 0.023 13.9 0.3 0.073 12.3 0.3 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA78641.1 - 0.11 11.6 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein TraG-D_C PF12696.7 EFA78642.1 - 0.98 9.4 3.6 3.5 7.6 3.6 2.0 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG 7tm_2 PF00002.24 EFA78646.1 - 2.6e-13 49.8 22.2 4.3e-13 49.1 22.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) SLC3A2_N PF16028.5 EFA78646.1 - 0.0026 17.3 0.6 0.0026 17.3 0.6 2.2 3 0 0 3 3 3 1 Solute carrier family 3 member 2 N-terminus 7tm_1 PF00001.21 EFA78646.1 - 0.0069 15.8 21.1 0.01 15.2 21.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 EFA78646.1 - 0.45 10.6 5.5 0.37 10.9 2.5 2.4 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term bZIP_1 PF00170.21 EFA78647.1 - 2.1e-12 47.0 10.9 2.1e-12 47.0 10.9 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFA78647.1 - 3.2e-10 39.9 9.0 3.2e-10 39.9 9.0 2.7 4 0 0 4 4 4 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFA78647.1 - 0.00013 22.4 7.5 0.00013 22.4 7.5 3.4 3 1 0 3 3 3 1 bZIP Maf transcription factor TruD PF01142.18 EFA78648.1 - 6.1e-56 190.0 1.7 3e-43 148.2 0.4 3.5 2 1 0 3 3 3 3 tRNA pseudouridine synthase D (TruD) DUF1682 PF07946.14 EFA78648.1 - 1.1 8.4 10.2 0.067 12.4 4.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) Kelch_6 PF13964.6 EFA78649.1 - 6.5e-12 45.3 6.3 1.5e-09 37.8 0.2 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 EFA78649.1 - 0.042 13.9 5.2 0.29 11.2 0.1 2.7 2 0 0 2 2 2 0 Kelch motif DivIVA PF05103.13 EFA78649.1 - 0.13 12.3 5.0 0.14 12.3 0.2 2.5 2 0 0 2 2 2 0 DivIVA protein Kelch_2 PF07646.15 EFA78649.1 - 0.22 11.6 1.6 2.1 8.4 0.2 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 EFA78649.1 - 1.9 8.2 4.3 0.62 9.7 0.4 2.2 2 0 0 2 2 2 0 Kelch motif CTD_bind PF04818.13 EFA78650.1 - 3.2e-05 24.7 0.0 0.00014 22.6 0.0 2.2 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.8 EFA78650.1 - 0.00019 21.8 0.1 0.00019 21.8 0.1 8.8 6 2 0 7 7 7 1 Subunit of cleavage factor IA Pcf11 POT1PC PF16686.5 EFA78651.1 - 4.3e-06 26.7 0.3 0.0001 22.2 0.0 2.7 1 1 1 2 2 2 1 ssDNA-binding domain of telomere protection protein PSS PF03034.15 EFA78652.1 - 7.7e-79 265.3 7.9 4.6e-53 180.7 4.3 2.2 1 1 1 2 2 2 2 Phosphatidyl serine synthase DUF4131 PF13567.6 EFA78652.1 - 0.076 12.7 2.6 0.46 10.1 0.4 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4131) DUF1129 PF06570.11 EFA78652.1 - 0.17 11.4 0.8 5.9 6.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) polyprenyl_synt PF00348.17 EFA78653.1 - 1.8e-68 230.4 0.0 2.4e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase EFG_C PF00679.24 EFA78655.1 - 7.7e-22 77.1 0.0 1.1e-20 73.5 0.0 2.2 1 1 1 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFA78655.1 - 0.13 12.0 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Elongation factor G, domain IV GTP_EFTU PF00009.27 EFA78656.1 - 1.5e-58 197.6 0.0 3e-58 196.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain bZIP_Maf PF03131.17 EFA78656.1 - 7.6e-09 36.0 10.5 7.6e-09 36.0 10.5 2.1 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EFA78656.1 - 2.1e-07 30.9 16.6 2.1e-07 30.9 16.6 1.8 2 0 0 2 2 1 1 bZIP transcription factor GTP_EFTU_D2 PF03144.25 EFA78656.1 - 4.8e-07 30.1 0.0 1.3e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 TMF_TATA_bd PF12325.8 EFA78656.1 - 0.0019 18.4 1.6 0.015 15.5 1.5 2.5 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding EFG_II PF14492.6 EFA78656.1 - 0.0061 16.6 0.0 0.018 15.1 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II bZIP_2 PF07716.15 EFA78656.1 - 0.014 15.5 11.0 0.014 15.5 11.0 2.0 1 1 1 2 2 2 0 Basic region leucine zipper Pex26 PF07163.12 EFA78656.1 - 0.18 11.1 4.2 0.21 10.9 2.1 2.1 3 0 0 3 3 3 0 Pex26 protein YabA PF06156.13 EFA78656.1 - 0.23 12.1 6.9 0.13 12.9 3.4 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 EFA78656.1 - 0.25 10.6 5.4 0.6 9.4 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RNA_pol_Rpb5_C PF01191.19 EFA78656.1 - 0.78 9.6 3.8 3.5 7.6 0.2 2.7 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain FlaC_arch PF05377.11 EFA78656.1 - 0.84 10.1 8.4 0.12 12.7 2.5 2.7 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 EFA78656.1 - 1.2 9.5 6.8 1.4 9.4 5.1 2.0 1 1 0 1 1 1 0 Centromere protein H (CENP-H) APG6_N PF17675.1 EFA78656.1 - 1.3 9.6 14.1 0.12 13.0 9.0 1.9 2 0 0 2 2 1 0 Apg6 coiled-coil region TMPIT PF07851.13 EFA78656.1 - 9.2 5.4 8.0 19 4.3 8.0 1.5 1 0 0 1 1 1 0 TMPIT-like protein YecM PF06185.12 EFA78657.1 - 5e-06 26.3 0.2 2.9e-05 23.8 0.2 1.9 2 0 0 2 2 2 1 YecM protein Rad9 PF04139.13 EFA78659.1 - 0.048 13.1 0.8 0.053 13.0 0.8 1.1 1 0 0 1 1 1 0 Rad9 zf-CCCH PF00642.24 EFA78660.1 - 0.0047 16.8 3.4 0.0097 15.8 3.4 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FRB_dom PF08771.11 EFA78660.1 - 0.061 13.7 4.1 0.12 12.8 0.4 2.4 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain Torus PF16131.5 EFA78660.1 - 0.31 11.8 0.0 0.31 11.8 0.0 3.2 3 0 0 3 3 3 0 Torus domain zf-CCCH_4 PF18044.1 EFA78660.1 - 0.46 10.4 3.8 0.78 9.6 3.8 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFA78660.1 - 1.2 9.3 8.4 2.7 8.2 8.4 1.6 1 0 0 1 1 1 0 Zinc finger domain RNase_H2_suC PF08615.11 EFA78661.1 - 2.1e-17 63.6 0.5 2.1e-17 63.6 0.5 2.7 2 2 0 2 2 2 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF4358 PF14270.6 EFA78661.1 - 0.32 11.3 0.0 0.32 11.3 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4358) GAGA_bind PF06217.12 EFA78662.1 - 0.13 12.5 18.3 0.17 12.1 18.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Serinc PF03348.15 EFA78662.1 - 0.74 8.7 8.5 0.96 8.3 8.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CCSAP PF15748.5 EFA78662.1 - 0.85 9.7 27.5 1.5 8.9 27.5 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 EFA78662.1 - 1.4 8.7 25.6 2.6 7.8 25.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paramyxo_ncap PF00973.19 EFA78662.1 - 2.5 6.9 16.0 3 6.7 16.0 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Hid1 PF12722.7 EFA78662.1 - 4.8 5.2 19.3 5.9 4.9 19.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 EFA78662.1 - 6.8 5.1 29.5 9 4.7 29.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 EFA78662.1 - 8.4 5.6 15.7 9.6 5.5 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DNA_ligase_OB_2 PF14743.6 EFA78664.1 - 0.053 13.5 0.0 0.064 13.3 0.0 1.1 1 0 0 1 1 1 0 DNA ligase OB-like domain MFS_1 PF07690.16 EFA78665.1 - 1e-31 110.2 40.6 3.5e-25 88.7 15.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRAPPC-Trs85 PF12739.7 EFA78666.1 - 1.7e-55 188.7 2.9 2.2e-49 168.6 2.3 2.4 1 1 1 2 2 2 2 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TRAPPC9-Trs120 PF08626.11 EFA78666.1 - 1.4e-09 36.0 1.4 2.9e-09 34.9 1.4 1.4 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.6 EFA78666.1 - 0.00015 21.9 0.0 0.00045 20.4 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF974 PF06159.13 EFA78666.1 - 0.00056 19.8 0.6 0.018 14.9 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF974) Transglut_C PF00927.22 EFA78666.1 - 0.015 15.4 0.3 16 5.7 0.0 4.1 3 1 1 4 4 4 0 Transglutaminase family, C-terminal ig like domain TPR_2 PF07719.17 EFA78666.1 - 0.064 13.4 0.6 0.71 10.1 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Ras PF00071.22 EFA78667.1 - 3.7e-07 29.9 3.1 4.1e-06 26.5 3.1 2.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA78667.1 - 0.055 13.7 0.7 0.81 9.9 0.7 2.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase XFP_C PF09363.10 EFA78667.1 - 0.058 12.9 1.8 0.12 11.9 0.1 2.0 2 0 0 2 2 2 0 XFP C-terminal domain Polysacc_syn_2C PF08485.10 EFA78667.1 - 0.77 9.5 5.0 8 6.2 0.4 2.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein C-terminal Pkinase PF00069.25 EFA78669.1 - 1.2e-78 264.1 0.1 5.3e-78 262.0 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain WD40 PF00400.32 EFA78669.1 - 1.7e-44 148.9 30.7 1.9e-09 37.9 0.1 8.7 8 0 0 8 8 8 6 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 EFA78669.1 - 3.7e-36 124.7 0.0 9.5e-36 123.4 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase ANAPC4_WD40 PF12894.7 EFA78669.1 - 4.5e-23 81.4 2.6 6.4e-07 29.6 0.0 6.5 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain zf-CCHH PF10283.9 EFA78669.1 - 3.6e-12 46.0 4.9 7.4e-12 45.0 4.9 1.6 1 0 0 1 1 1 1 PBZ domain FHA PF00498.26 EFA78669.1 - 8.5e-12 45.3 0.2 2.2e-11 43.9 0.2 1.8 1 0 0 1 1 1 1 FHA domain LisH PF08513.11 EFA78669.1 - 6.5e-09 35.4 0.3 6.5e-09 35.4 0.3 1.8 2 0 0 2 2 1 1 LisH Kdo PF06293.14 EFA78669.1 - 5.2e-07 29.2 0.1 9.3e-07 28.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFA78669.1 - 1.1e-06 28.3 0.0 2.1e-05 24.0 0.0 2.4 1 1 1 2 2 2 1 Kinase-like WD40_like PF17005.5 EFA78669.1 - 3.9e-05 23.1 0.0 0.45 9.8 0.0 3.6 3 0 0 3 3 3 1 WD40-like domain Pkinase_fungal PF17667.1 EFA78669.1 - 0.00074 18.4 0.0 0.00074 18.4 0.0 3.4 4 0 0 4 4 4 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFA78669.1 - 0.0023 17.5 0.1 0.0063 16.1 0.1 1.7 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Yop-YscD_cpl PF16697.5 EFA78669.1 - 0.0023 18.2 0.0 0.0078 16.5 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FeoB_N PF02421.18 EFA78669.1 - 0.028 14.0 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B PPP4R2 PF09184.11 EFA78669.1 - 3.6 7.1 49.5 0.49 9.9 19.5 2.4 2 0 0 2 2 2 0 PPP4R2 Endostatin PF06482.11 EFA78669.1 - 9.7 5.5 20.1 0.27 10.6 6.8 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Imm-NTF2 PF15655.6 EFA78671.1 - 0.0037 17.5 1.5 0.0069 16.7 0.5 2.0 1 1 0 1 1 1 1 NTF2 fold immunity protein FapA PF03961.13 EFA78671.1 - 0.22 10.1 9.7 0.36 9.4 9.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A COQ9 PF08511.11 EFA78672.1 - 1.2e-29 101.9 0.4 2.4e-29 100.9 0.4 1.5 1 0 0 1 1 1 1 COQ9 Aldo_ket_red PF00248.21 EFA78672.1 - 0.0004 19.7 0.1 0.017 14.3 0.1 2.2 1 1 1 2 2 2 2 Aldo/keto reductase family KOG2701 PF09762.9 EFA78673.1 - 2.3e-62 210.4 0.0 2.3e-62 210.4 0.0 3.6 4 0 0 4 4 4 1 Coiled-coil domain-containing protein (DUF2037) Med10 PF09748.9 EFA78673.1 - 0.00018 21.4 2.1 0.0012 18.7 0.2 2.8 2 0 0 2 2 2 1 Transcription factor subunit Med10 of Mediator complex Hemerythrin PF01814.23 EFA78673.1 - 0.0068 17.0 3.1 0.24 12.0 0.6 2.8 2 0 0 2 2 2 2 Hemerythrin HHE cation binding domain Homeobox_KN PF05920.11 EFA78674.1 - 2e-18 66.0 0.1 4.1e-18 65.0 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFA78674.1 - 9.8e-11 41.3 0.5 2.4e-10 40.1 0.3 1.8 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 EFA78674.1 - 0.019 14.4 1.3 0.12 11.8 0.0 2.6 2 1 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez FNIP PF05725.12 EFA78675.1 - 1.2e-33 114.9 21.7 3.1e-10 40.0 0.2 7.4 4 2 3 7 7 7 6 FNIP Repeat EMP70 PF02990.16 EFA78676.1 - 2e-187 624.0 110.6 1e-73 248.8 29.5 4.1 3 1 1 4 4 4 4 Endomembrane protein 70 FYRN PF05964.14 EFA78676.1 - 0.018 14.8 0.7 56 3.7 0.0 3.8 3 0 0 3 3 3 0 F/Y-rich N-terminus V4R PF02830.18 EFA78676.1 - 0.062 13.3 0.0 18 5.4 0.0 2.4 2 0 0 2 2 2 0 V4R domain Herpes_UL92 PF03048.14 EFA78676.1 - 0.36 10.6 5.1 20 4.9 0.0 3.9 3 1 0 3 3 3 0 UL92 family FNIP PF05725.12 EFA78677.1 - 6.9e-11 42.1 5.0 0.0047 17.1 0.0 5.6 3 3 1 4 4 4 4 FNIP Repeat FNIP PF05725.12 EFA78678.1 - 6.2e-18 64.7 24.6 5.1e-05 23.3 0.0 10.3 8 2 2 10 10 10 5 FNIP Repeat F-box_4 PF15966.5 EFA78678.1 - 0.11 12.4 0.2 0.67 9.9 0.0 2.4 2 0 0 2 2 2 0 F-box F-box PF00646.33 EFA78678.1 - 3.7 7.5 6.0 4.7 7.2 0.3 3.8 3 0 0 3 3 3 0 F-box domain Uma2 PF05685.12 EFA78679.1 - 0.0054 16.3 0.0 0.0095 15.5 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease PEX11 PF05648.14 EFA78680.1 - 0.07 12.6 6.9 0.95 8.9 0.0 2.2 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) MscS_TM PF12794.7 EFA78680.1 - 7.7 5.3 6.4 13 4.5 6.4 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 EIF4E-T PF10477.9 EFA78680.1 - 7.7 5.2 45.4 13 4.4 45.4 1.3 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Rhomboid PF01694.22 EFA78682.1 - 2.5e-14 53.5 12.3 2.5e-14 53.5 12.3 1.7 2 0 0 2 2 2 1 Rhomboid family MBOAT_2 PF13813.6 EFA78682.1 - 0.11 12.8 1.2 0.3 11.4 0.8 2.0 1 1 0 1 1 1 0 Membrane bound O-acyl transferase family Ribosomal_L30 PF00327.20 EFA78683.1 - 1.4e-13 50.5 0.6 2.1e-13 50.0 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_S17e PF00833.18 EFA78684.1 - 5.6e-59 197.4 1.3 6e-59 197.3 1.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 MFS_1 PF07690.16 EFA78685.1 - 2.2e-42 145.3 53.3 9.2e-28 97.2 36.4 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFA78685.1 - 2.6e-14 52.6 25.6 9.2e-14 50.8 25.2 2.1 2 1 0 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.24 EFA78685.1 - 6.2e-10 38.5 15.7 2.8e-06 26.5 1.0 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter PUCC PF03209.15 EFA78685.1 - 4.9e-09 35.7 13.3 2.8e-05 23.3 0.2 3.7 2 2 3 5 5 5 4 PUCC protein MFS_3 PF05977.13 EFA78685.1 - 6e-06 24.9 5.2 0.00034 19.2 0.5 2.3 3 0 0 3 3 3 2 Transmembrane secretion effector BT1 PF03092.16 EFA78685.1 - 0.00044 18.6 15.6 0.0035 15.6 4.5 2.5 1 1 2 3 3 3 2 BT1 family Pkinase PF00069.25 EFA78686.1 - 4.8e-75 252.3 0.0 6.2e-75 252.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78686.1 - 5.7e-36 124.1 0.0 7.5e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA78686.1 - 0.0001 21.7 0.1 0.0007 19.0 0.0 2.0 1 1 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 EFA78686.1 - 0.00015 22.4 0.4 0.00015 22.4 0.4 2.4 2 1 0 2 2 2 1 Protein kinase C terminal domain FTA2 PF13095.6 EFA78686.1 - 0.00042 20.0 0.1 0.29 10.7 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EFA78686.1 - 0.0033 16.4 1.4 0.0051 15.8 1.4 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFA78686.1 - 0.0036 16.1 4.4 0.013 14.3 4.4 1.9 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFA78686.1 - 0.005 16.8 0.0 0.0087 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA78686.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ndc1_Nup PF09531.10 EFA78686.1 - 2.7 6.6 5.6 3.4 6.2 5.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MIOX PF05153.15 EFA78687.1 - 1.4e-94 316.3 7.4 2.9e-76 256.3 0.5 2.0 1 1 1 2 2 2 2 Myo-inositol oxygenase HD PF01966.22 EFA78687.1 - 0.16 12.2 0.0 0.81 9.9 0.0 2.0 2 0 0 2 2 2 0 HD domain DUF1304 PF06993.12 EFA78688.1 - 0.0024 17.8 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) DUF1129 PF06570.11 EFA78688.1 - 0.037 13.5 0.1 0.07 12.6 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) ENOD93 PF03386.14 EFA78688.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein DUF846 PF05832.12 EFA78689.1 - 1.2e-49 167.9 14.3 1.5e-49 167.6 14.3 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Alpha_E2_glycop PF00943.19 EFA78689.1 - 0.13 11.0 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Alphavirus E2 glycoprotein Phage_holin_3_6 PF07332.11 EFA78689.1 - 0.15 12.1 7.8 0.77 9.8 0.4 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Halogen_Hydrol PF10112.9 EFA78689.1 - 6.1 6.8 6.4 14 5.7 0.6 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DSPc PF00782.20 EFA78690.1 - 1.3e-07 31.5 0.0 1.6e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA78690.1 - 4.5e-06 26.4 0.0 5.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFA78690.1 - 2.6e-05 23.9 0.0 3.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EFA78690.1 - 0.0023 18.1 0.0 0.003 17.7 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate DHHC PF01529.20 EFA78691.1 - 5.2e-20 71.9 18.6 5.2e-20 71.9 18.6 3.3 3 1 0 3 3 3 1 DHHC palmitoyltransferase zf-B_box PF00643.24 EFA78691.1 - 2.2e-05 24.5 8.1 2.2e-05 24.5 8.1 2.6 2 1 0 2 2 2 1 B-box zinc finger DUF1660 PF07874.11 EFA78691.1 - 0.019 15.5 2.4 0.019 15.5 2.4 3.8 2 0 0 2 2 2 0 Prophage protein (DUF1660) Snapin_Pallidin PF14712.6 EFA78691.1 - 0.025 15.0 1.9 0.025 15.0 1.9 3.1 3 1 1 4 4 4 0 Snapin/Pallidin VHS PF00790.19 EFA78693.1 - 2.2e-22 79.4 0.3 4.3e-22 78.5 0.0 1.6 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EFA78693.1 - 5.1e-14 52.3 3.6 1.7e-13 50.7 3.6 2.0 1 0 0 1 1 1 1 GAT domain Phage_Gp15 PF06854.11 EFA78693.1 - 0.22 11.5 0.0 0.22 11.5 0.0 2.8 4 0 0 4 4 4 0 Bacteriophage Gp15 protein Misat_Tub_SegII PF10644.9 EFA78694.1 - 4.5e-27 94.7 7.1 4.5e-27 94.7 7.1 2.0 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFA78694.1 - 7.4e-24 84.4 0.4 7.4e-24 84.4 0.4 1.9 2 0 0 2 2 2 1 Tubulin domain Tubulin PF00091.25 EFA78694.1 - 4.6e-11 43.3 6.5 3.7e-07 30.5 0.1 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain SUIM_assoc PF16619.5 EFA78694.1 - 0.15 12.2 5.2 1.1 9.4 0.6 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 START PF01852.19 EFA78695.1 - 1.2e-08 34.6 0.2 2e-08 33.9 0.2 1.3 1 0 0 1 1 1 1 START domain YABBY PF04690.13 EFA78696.1 - 2.9 8.4 20.6 0.85 10.2 11.9 2.5 2 0 0 2 2 2 0 YABBY protein Mit_KHE1 PF10173.9 EFA78696.1 - 6.7 6.8 13.9 0.23 11.5 6.5 2.3 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related RhoGEF PF00621.20 EFA78697.1 - 2e-32 112.9 1.6 2e-32 112.9 1.6 2.3 2 2 0 2 2 2 1 RhoGEF domain PH PF00169.29 EFA78697.1 - 0.004 17.6 1.0 0.0095 16.4 1.0 1.7 1 0 0 1 1 1 1 PH domain FNIP PF05725.12 EFA78698.1 - 9.7e-17 60.9 32.0 6.5e-05 23.0 0.4 9.3 4 3 4 9 9 9 8 FNIP Repeat LRR_4 PF12799.7 EFA78698.1 - 0.033 14.6 10.2 1.2 9.7 0.6 5.1 3 2 1 5 5 4 0 Leucine Rich repeats (2 copies) F-box_5 PF18511.1 EFA78698.1 - 0.12 11.9 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 F-box Cyclin PF08613.11 EFA78699.1 - 5.7e-24 85.3 0.4 5.7e-24 85.3 0.4 2.1 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFA78699.1 - 1.6e-09 37.6 1.8 1.7e-09 37.5 0.1 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain FA_hydroxylase PF04116.13 EFA78700.1 - 2.1e-17 63.7 15.7 3.8e-17 62.9 15.7 1.4 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily WD40 PF00400.32 EFA78701.1 - 3.3e-29 100.5 29.4 2.9e-05 24.7 0.0 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78701.1 - 2.8e-08 33.9 1.7 0.24 11.7 0.1 4.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA78701.1 - 1.1e-06 27.6 8.4 0.024 13.3 0.2 5.0 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WDCP PF15390.6 EFA78701.1 - 0.47 8.8 11.6 0.11 10.8 8.4 1.5 1 1 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Stk19 PF10494.9 EFA78702.1 - 6e-21 75.2 1.4 8.7e-21 74.7 1.4 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 WAP PF00095.21 EFA78703.1 - 0.0012 19.2 11.8 0.0012 19.2 11.8 1.4 1 1 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' EGF_2 PF07974.13 EFA78704.1 - 3.9e-05 23.9 31.0 0.00061 20.1 10.5 2.6 2 0 0 2 2 2 2 EGF-like domain Lectin_C PF00059.21 EFA78704.1 - 0.0029 18.3 0.2 0.015 16.0 0.0 2.3 2 0 0 2 2 2 1 Lectin C-type domain EGF PF00008.27 EFA78704.1 - 0.37 11.1 20.5 0.1 12.9 5.6 2.7 2 0 0 2 2 2 0 EGF-like domain EGF_Tenascin PF18720.1 EFA78704.1 - 9.7 6.4 20.8 1.6 8.9 5.9 2.8 2 0 0 2 2 2 0 Tenascin EGF domain DUF2828 PF11443.8 EFA78705.1 - 1.2e-121 406.9 3.4 5.6e-101 338.6 1.5 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) VWA_CoxE PF05762.14 EFA78705.1 - 0.017 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein CobT_C PF11775.8 EFA78705.1 - 0.089 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain DUF816 PF05674.12 EFA78705.1 - 0.14 12.0 0.0 3.9 7.4 0.0 2.3 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF816) Lectin_C PF00059.21 EFA78706.1 - 0.046 14.5 1.4 0.25 12.1 0.2 2.9 3 0 0 3 3 3 0 Lectin C-type domain EGF_2 PF07974.13 EFA78706.1 - 1.3 9.5 13.4 2.8 8.4 13.4 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFA78706.1 - 1.6 8.9 8.5 3.6 7.8 8.5 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 EFA78707.1 - 1.5 9.2 11.9 3.4 8.1 11.9 1.6 1 0 0 1 1 1 0 EGF-like domain FNIP PF05725.12 EFA78708.1 - 7.6e-05 22.8 26.7 1 9.5 1.6 9.7 8 3 1 10 10 10 4 FNIP Repeat F-box_5 PF18511.1 EFA78708.1 - 0.0029 17.1 0.1 0.0057 16.2 0.1 1.4 1 0 0 1 1 1 1 F-box LRR_8 PF13855.6 EFA78708.1 - 0.023 14.5 0.0 4.2 7.2 0.0 4.0 3 1 0 3 3 3 0 Leucine rich repeat CBM49 PF09478.10 EFA78709.1 - 0.0011 19.3 0.3 0.0031 17.8 0.3 1.8 1 1 0 1 1 1 1 Carbohydrate binding domain CBM49 HARP PF07443.13 EFA78709.1 - 0.05 13.3 0.2 0.16 11.6 0.0 1.8 2 0 0 2 2 2 0 HepA-related protein (HARP) Arf PF00025.21 EFA78710.1 - 1.4e-14 54.0 0.5 7.4e-14 51.6 0.3 2.1 1 1 1 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EFA78710.1 - 0.0018 18.5 0.0 0.0038 17.4 0.0 1.6 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA78710.1 - 0.0037 17.3 0.0 0.033 14.3 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EFA78710.1 - 0.0051 16.1 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin cobW PF02492.19 EFA78710.1 - 0.018 14.7 0.1 0.13 11.8 0.1 1.9 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 EFA78710.1 - 0.019 14.4 0.2 0.045 13.2 0.2 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 EFA78710.1 - 0.037 13.9 0.0 0.63 9.9 0.1 2.1 1 1 1 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 EFA78710.1 - 0.04 13.8 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 EFA78710.1 - 0.057 12.9 0.0 0.065 12.8 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 EFA78710.1 - 0.06 13.0 0.1 0.29 10.8 0.1 1.8 1 1 1 2 2 2 0 Thymidylate kinase ABC_tran PF00005.27 EFA78710.1 - 0.062 13.8 0.0 0.076 13.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter SRP54 PF00448.22 EFA78710.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EFA78710.1 - 0.07 13.3 0.0 0.24 11.6 0.0 1.6 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 EFA78710.1 - 0.075 12.2 0.0 0.086 12.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Viral_helicase1 PF01443.18 EFA78710.1 - 0.19 11.5 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Gpi1 PF05024.15 EFA78711.1 - 8.9e-36 123.7 9.5 2.2e-35 122.4 9.5 1.7 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) IBR PF01485.21 EFA78711.1 - 6.7e-19 67.9 32.6 2.4e-13 50.1 7.2 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain GATase PF00117.28 EFA78711.1 - 7.5e-09 35.6 0.0 2.4e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase class-I UBA PF00627.31 EFA78711.1 - 0.00032 20.5 0.0 0.0011 18.9 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain TetR_C_17 PF17922.1 EFA78711.1 - 0.066 13.3 0.1 0.21 11.7 0.1 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain PBP1_TM PF14812.6 EFA78711.1 - 1.8 9.0 8.0 9.2 6.7 1.3 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ank_4 PF13637.6 EFA78713.1 - 1.4e-10 41.5 4.4 0.0045 17.5 0.2 4.6 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA78713.1 - 2.4e-10 40.8 12.6 2.5e-05 24.8 5.3 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA78713.1 - 1.2e-08 34.5 3.1 1.3 9.8 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 EFA78713.1 - 6.4e-07 29.5 4.0 0.0015 18.9 2.6 5.2 5 1 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 EFA78713.1 - 1.6e-05 25.1 0.4 0.0022 18.3 0.0 4.5 4 1 1 5 5 4 2 Ankyrin repeats (many copies) Apc15p PF05841.11 EFA78713.1 - 0.047 14.5 7.5 0.083 13.7 7.5 1.3 1 0 0 1 1 1 0 Apc15p protein TFB6 PF17110.5 EFA78713.1 - 0.077 12.7 1.6 0.15 11.8 1.6 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Med3 PF11593.8 EFA78713.1 - 0.22 10.7 18.7 0.32 10.1 18.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Presenilin PF01080.17 EFA78713.1 - 0.35 9.6 1.5 0.43 9.3 1.5 1.1 1 0 0 1 1 1 0 Presenilin P5-ATPase PF12409.8 EFA78713.1 - 1.9 8.6 4.2 4 7.6 4.2 1.5 1 0 0 1 1 1 0 P5-type ATPase cation transporter Rsc14 PF08586.10 EFA78713.1 - 2.1 9.2 8.4 1.6 9.6 6.3 1.9 2 1 0 2 2 1 0 RSC complex, Rsc14/Ldb7 subunit Pyr_redox_2 PF07992.14 EFA78714.1 - 6.9e-57 192.9 0.0 8.5e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA78714.1 - 1.9e-10 41.2 0.0 6.8e-09 36.2 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase IF-2 PF11987.8 EFA78714.1 - 0.052 13.7 0.0 0.23 11.6 0.1 2.0 2 0 0 2 2 2 0 Translation-initiation factor 2 DUF4041 PF13250.6 EFA78714.1 - 9 6.3 10.4 5.8 6.9 6.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4041) TPR_17 PF13431.6 EFA78715.1 - 2e-127 406.8 36.4 3.2e-10 39.7 0.1 14.0 14 0 0 14 14 14 13 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78715.1 - 7.6e-24 83.1 46.9 0.098 12.4 0.4 13.2 13 0 0 13 13 13 12 TPR repeat DUF3255 PF11631.8 EFA78715.1 - 5.1e-06 26.4 24.6 3.5 7.5 0.1 10.0 1 1 10 11 11 11 2 Protein of unknown function (DUF3255) NleF_casp_inhib PF16809.5 EFA78715.1 - 0.0026 17.7 17.6 33 4.4 0.1 9.9 5 4 7 13 13 13 0 NleF caspase inhibitor Anth_Ig PF05587.13 EFA78715.1 - 0.011 16.0 22.7 21 5.5 0.0 10.7 13 0 0 13 13 13 0 Anthrax receptor extracellular domain IMPa_N_2 PF18650.1 EFA78715.1 - 0.31 10.3 14.0 8.8 5.5 0.1 5.2 3 1 2 6 6 6 0 Immunomodulating metalloprotease N-terminal domain DUF1663 PF07909.11 EFA78715.1 - 1 8.0 4.3 13 4.4 0.0 4.1 3 2 1 5 5 5 0 Protein of unknown function (DUF1663) Bac_rhamnosid_N PF08531.10 EFA78715.1 - 1.2 8.9 13.9 33 4.3 0.1 5.0 2 1 4 6 6 6 0 Alpha-L-rhamnosidase N-terminal domain TPR_8 PF13181.6 EFA78715.1 - 1.4 9.3 32.0 1.5e+02 3.0 0.3 13.6 15 3 1 16 16 14 0 Tetratricopeptide repeat gerPA PF10676.9 EFA78715.1 - 1.6 9.1 28.4 2.6 8.3 0.4 8.0 8 0 0 8 8 8 0 Spore germination protein gerPA/gerPF DUF3445 PF11927.8 EFA78715.1 - 1.8 8.1 4.8 3.5 7.2 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3445) TPR_19 PF14559.6 EFA78715.1 - 2 9.0 12.1 45 4.7 0.1 6.3 8 0 0 8 8 8 0 Tetratricopeptide repeat PBP PF01161.20 EFA78716.1 - 4.9e-18 65.7 0.1 6.5e-18 65.3 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF1560 PF07597.11 EFA78716.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1560) DUF3630 PF12305.8 EFA78717.1 - 0.071 13.2 0.0 0.082 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3630) Phage_spike_2 PF18781.1 EFA78717.1 - 0.16 12.0 0.0 0.23 11.5 0.0 1.3 1 1 0 1 1 1 0 Phage spike trimer TMA7 PF09072.10 EFA78718.1 - 4.7e-26 91.4 21.5 5.2e-26 91.3 21.5 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 EMP70 PF02990.16 EFA78719.1 - 5.9e-44 150.6 27.2 5.9e-44 150.6 27.2 1.8 2 1 0 2 2 2 1 Endomembrane protein 70 SpoVAC_SpoVAEB PF03862.13 EFA78719.1 - 0.13 12.6 5.4 6 7.2 2.9 2.6 2 0 0 2 2 2 0 SpoVAC/SpoVAEB sporulation membrane protein Kelch_6 PF13964.6 EFA78720.1 - 1.6e-15 56.7 4.0 1.1e-08 35.1 0.0 5.0 5 0 0 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA78720.1 - 0.00018 21.6 8.3 0.00038 20.5 8.3 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA78720.1 - 0.009 15.6 0.3 0.041 13.5 0.0 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EFA78720.1 - 0.026 14.5 2.5 0.15 12.0 0.1 3.0 2 0 0 2 2 2 0 Kelch motif Terpene_synth_C PF03936.16 EFA78721.1 - 0.015 14.6 0.5 0.03 13.7 0.5 1.6 1 1 0 1 1 1 0 Terpene synthase family, metal binding domain DUF3662 PF12401.8 EFA78721.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) Kelch_6 PF13964.6 EFA78722.1 - 1.7e-13 50.3 6.6 1.9e-06 27.9 0.8 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EFA78722.1 - 0.036 14.1 2.4 4.8 7.3 0.1 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 EFA78722.1 - 0.051 13.2 0.0 0.35 10.5 0.0 2.5 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 EFA78722.1 - 0.29 11.2 4.0 0.18 11.8 0.3 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 EFA78722.1 - 0.37 10.8 3.6 2.5 8.2 0.0 4.0 4 0 0 4 4 4 0 Galactose oxidase, central domain 2OG-FeII_Oxy_3 PF13640.6 EFA78723.1 - 1.4e-12 48.3 0.0 2.3e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 EFA78723.1 - 0.0004 20.7 0.1 0.037 14.3 0.1 2.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Pox_C4_C10 PF03336.13 EFA78723.1 - 0.0013 17.9 0.0 0.0014 17.8 0.0 1.1 1 0 0 1 1 1 1 Poxvirus C4/C10 protein 2OG-FeII_Oxy PF03171.20 EFA78723.1 - 0.029 14.8 0.0 0.076 13.5 0.0 1.7 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily FNIP PF05725.12 EFA78724.1 - 6e-45 151.2 37.7 7.2e-12 45.3 0.0 9.4 9 1 1 10 10 10 7 FNIP Repeat F-box_5 PF18511.1 EFA78724.1 - 5.8e-05 22.6 0.2 0.00013 21.5 0.2 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA78724.1 - 0.088 12.7 0.2 0.26 11.2 0.2 1.8 1 0 0 1 1 1 0 F-box-like Acetyltransf_1 PF00583.25 EFA78725.1 - 1.1e-15 57.9 0.0 1.3e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA78725.1 - 7.9e-13 48.6 0.0 1.3e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA78725.1 - 1.9e-11 44.0 0.1 2.9e-11 43.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFA78725.1 - 7.6e-09 35.9 0.1 8.8e-09 35.7 0.1 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFA78725.1 - 0.00032 20.8 0.0 0.00041 20.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA78725.1 - 0.00043 20.2 0.0 0.00083 19.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 EFA78725.1 - 0.00067 19.4 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 EFA78725.1 - 0.0017 19.1 0.0 0.002 18.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFA78725.1 - 0.0027 17.2 0.1 0.003 17.0 0.1 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_18 PF18014.1 EFA78725.1 - 0.021 14.6 0.0 6.5 6.6 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFA78725.1 - 0.026 14.2 0.0 0.069 12.8 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFA78725.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.7 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 EFA78725.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Ank_2 PF12796.7 EFA78726.1 - 1.7e-20 73.4 4.2 8.8e-06 26.2 0.1 5.5 2 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78726.1 - 1.6e-17 63.6 3.9 0.047 14.3 0.0 8.4 4 3 4 9 9 9 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78726.1 - 3.2e-14 52.8 1.3 0.036 14.4 0.0 7.4 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78726.1 - 1.1e-13 49.9 5.2 20 6.2 0.0 10.9 11 1 1 12 12 12 3 Ankyrin repeat DUF5049 PF16468.5 EFA78726.1 - 0.12 12.3 0.2 9.2 6.3 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA78726.1 - 0.96 10.0 5.7 68 4.2 0.1 5.5 5 2 0 5 5 5 0 Ankyrin repeat SLBP_RNA_bind PF15247.6 EFA78727.1 - 7.2e-31 106.1 5.5 7.2e-31 106.1 5.5 2.5 3 1 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain Haspin_kinase PF12330.8 EFA78728.1 - 6.4e-06 25.3 11.4 1.5e-05 24.1 11.4 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_Tyr PF07714.17 EFA78728.1 - 7.3e-05 22.2 0.9 0.00012 21.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase SDA1 PF05285.12 EFA78728.1 - 0.068 12.6 54.4 0.012 15.1 41.3 2.3 2 0 0 2 2 2 0 SDA1 DUF2967 PF11179.8 EFA78728.1 - 0.12 10.5 3.2 0.22 9.6 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) CDC27 PF09507.10 EFA78728.1 - 0.42 10.0 44.0 0.0061 16.0 33.2 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 BUD22 PF09073.10 EFA78728.1 - 2.3 7.4 46.4 0.12 11.7 32.5 2.3 2 0 0 2 2 2 0 BUD22 Kelch_4 PF13418.6 EFA78729.1 - 2.9e-09 36.8 5.6 3.5e-05 23.7 0.2 3.3 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA78729.1 - 4.6e-09 36.2 2.1 0.00084 19.5 0.0 4.5 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA78729.1 - 4.2e-08 32.6 2.5 0.028 14.0 0.0 4.5 3 1 0 3 3 3 3 Kelch motif zf-B_box PF00643.24 EFA78729.1 - 1.6e-05 25.0 6.3 3.9e-05 23.7 6.3 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA78729.1 - 0.00065 19.9 0.1 30 5.1 0.1 5.0 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA78729.1 - 0.011 15.7 5.3 1.1 9.3 0.0 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 EFA78729.1 - 0.015 15.2 0.0 1.8 8.7 0.0 2.8 2 0 0 2 2 2 0 Kelch motif DUF2400 PF09674.10 EFA78729.1 - 2 8.3 5.4 1.1 9.2 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) Kelch_6 PF13964.6 EFA78730.1 - 2.7e-17 62.4 2.0 3e-11 43.2 0.1 4.6 3 1 1 4 4 4 2 Kelch motif zf-B_box PF00643.24 EFA78730.1 - 8.8e-06 25.8 7.6 1.7e-05 24.8 7.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA78730.1 - 7e-05 22.3 0.0 0.00024 20.6 0.0 2.0 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 EFA78730.1 - 0.0018 18.2 1.1 0.052 13.5 0.1 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EFA78730.1 - 0.023 14.7 0.4 2.2 8.3 0.0 3.7 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA78730.1 - 0.036 14.1 1.5 0.077 13.0 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 EFA78730.1 - 0.1 12.9 0.0 2.2 8.7 0.0 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain Plk4_PB2 PF18409.1 EFA78730.1 - 9.8 6.9 8.1 1.4 9.6 1.3 2.8 1 1 1 3 3 3 0 Polo-like Kinase 4 Polo Box 2 FNIP PF05725.12 EFA78731.1 - 2.3e-142 463.0 92.0 4.6e-16 58.7 1.9 17.2 10 4 7 18 18 18 17 FNIP Repeat Pkinase PF00069.25 EFA78731.1 - 6.6e-38 130.6 5.0 1.2e-33 116.6 0.2 2.8 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78731.1 - 1.4e-14 54.0 0.6 3.5e-08 33.1 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase RIO1 PF01163.22 EFA78731.1 - 0.0013 18.4 0.1 0.17 11.5 0.0 2.7 3 0 0 3 3 3 1 RIO1 family Kinase-like PF14531.6 EFA78731.1 - 0.012 14.9 0.0 3 7.1 0.0 2.7 3 0 0 3 3 3 0 Kinase-like Kdo PF06293.14 EFA78731.1 - 0.013 14.8 0.0 0.46 9.8 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA78731.1 - 0.051 13.5 0.0 4.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family FAM176 PF14851.6 EFA78732.1 - 0.0099 15.6 0.8 0.0099 15.6 0.8 2.6 3 0 0 3 3 3 2 FAM176 family PBP1_TM PF14812.6 EFA78732.1 - 0.064 13.6 19.1 0.065 13.6 11.0 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-Di19 PF05605.12 EFA78732.1 - 0.1 12.9 6.9 0.63 10.4 3.3 2.6 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding RXT2_N PF08595.11 EFA78732.1 - 0.37 10.8 13.3 1.2 9.2 5.2 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 EFA78732.1 - 0.58 10.0 12.7 2.5 7.9 1.8 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Fer2 PF00111.27 EFA78732.1 - 0.63 10.0 6.7 4.2 7.4 0.0 3.5 3 0 0 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain CENP-B_dimeris PF09026.10 EFA78732.1 - 0.98 9.9 23.1 2.1 8.8 8.3 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TRAP_alpha PF03896.16 EFA78732.1 - 1.3 8.2 7.2 3.4 6.8 0.3 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 EFA78732.1 - 3.2 7.0 24.2 0.63 9.3 0.5 2.6 3 0 0 3 3 3 0 NOA36 protein Nop14 PF04147.12 EFA78732.1 - 5.8 5.0 15.8 2.8 6.0 2.4 2.1 2 0 0 2 2 2 0 Nop14-like family Afi1 PF07792.12 EFA78732.1 - 6.6 7.2 11.6 3.9 8.0 2.9 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Uma2 PF05685.12 EFA78733.1 - 0.0009 18.8 0.1 0.0017 17.9 0.0 1.5 2 0 0 2 2 2 1 Putative restriction endonuclease FHA PF00498.26 EFA78735.1 - 3.8e-06 27.2 0.1 1e-05 25.8 0.1 1.7 1 1 1 2 2 2 1 FHA domain Macoilin PF09726.9 EFA78735.1 - 0.31 9.6 20.5 0.34 9.4 20.5 1.3 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 EFA78735.1 - 2.6 5.0 17.3 3.4 4.7 17.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FNIP PF05725.12 EFA78736.1 - 3.8e-26 91.0 11.4 1.9e-10 40.7 0.0 8.2 5 1 3 8 8 8 7 FNIP Repeat FNIP PF05725.12 EFA78737.1 - 9.8e-41 137.7 55.7 7.1e-10 38.9 0.1 15.0 13 2 1 14 14 14 8 FNIP Repeat F-box_5 PF18511.1 EFA78737.1 - 0.0018 17.8 1.6 0.078 12.6 0.1 2.8 3 0 0 3 3 3 1 F-box DCP2 PF05026.13 EFA78737.1 - 0.22 11.9 3.6 1.7 9.0 0.2 3.4 3 0 0 3 3 3 0 Dcp2, box A domain NUC130_3NT PF08158.12 EFA78737.1 - 0.7 10.3 6.3 12 6.3 0.0 4.2 5 0 0 5 5 5 0 NUC130/3NT domain RmlD_sub_bind PF04321.17 EFA78738.1 - 1e-61 208.6 0.0 1.3e-61 208.2 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EFA78738.1 - 2.1e-19 70.0 0.0 2.8e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFA78738.1 - 1.6e-16 60.3 0.7 4.6e-15 55.5 0.7 2.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFA78738.1 - 1.4e-10 41.1 0.1 2.1e-10 40.5 0.1 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFA78738.1 - 5e-08 32.3 0.3 6.6e-08 31.9 0.3 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFA78738.1 - 9.2e-05 21.7 0.1 0.0013 18.0 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein F-box-like PF12937.7 EFA78739.1 - 2.7e-10 40.0 1.0 4.8e-10 39.2 1.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA78739.1 - 5.3e-09 35.7 1.3 9e-09 35.0 1.3 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFA78739.1 - 0.015 15.2 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 F-box Glyco_hydro_42M PF08532.10 EFA78739.1 - 0.18 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase trimerisation domain Tweety PF04906.13 EFA78742.1 - 0.029 13.0 1.0 0.046 12.4 1.0 1.3 1 0 0 1 1 1 0 Tweety MatE PF01554.18 EFA78742.1 - 0.03 14.0 1.3 0.052 13.2 0.7 1.7 1 1 1 2 2 2 0 MatE Arg_repressor_C PF02863.18 EFA78742.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain TMEM132D_C PF15706.5 EFA78742.1 - 4 7.3 4.9 1.4 8.8 1.1 2.1 2 1 1 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term HIG_1_N PF04588.13 EFA78743.1 - 8.3e-08 32.3 0.5 1.1e-07 31.9 0.0 1.5 2 0 0 2 2 2 1 Hypoxia induced protein conserved region DUF1455 PF07306.11 EFA78743.1 - 0.068 13.1 0.0 0.09 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) Ank_4 PF13637.6 EFA78744.1 - 8.9e-31 105.9 8.5 0.00044 20.7 0.1 10.4 6 3 5 12 12 12 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA78744.1 - 1.4e-29 102.5 12.7 2.8e-07 31.0 0.0 8.1 4 3 5 9 9 9 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78744.1 - 1.6e-29 101.6 4.5 0.0067 16.7 0.0 12.8 7 2 6 13 13 13 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78744.1 - 1.8e-16 58.5 0.4 9.4 7.2 0.0 12.8 14 0 0 14 14 14 1 Ankyrin repeat DUF5049 PF16468.5 EFA78744.1 - 4.7e-05 23.2 4.2 8.1 6.4 0.0 6.6 5 1 2 7 7 7 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA78744.1 - 0.005 17.2 2.9 1.9e+02 2.7 0.0 7.0 7 1 0 7 7 7 0 Ankyrin repeat DUF2705 PF10920.8 EFA78745.1 - 0.062 12.6 3.4 0.48 9.7 4.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2705) PGAP1 PF07819.13 EFA78747.1 - 0.00014 21.6 0.4 0.00085 19.1 0.0 2.4 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFA78747.1 - 0.05 14.2 0.5 0.1 13.1 0.5 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family ETRAMP PF09716.10 EFA78747.1 - 0.19 11.8 4.5 0.56 10.3 1.2 3.0 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) RNR_N PF08343.10 EFA78748.1 - 0.046 13.7 1.0 0.046 13.7 1.0 2.1 1 1 1 2 2 2 0 Ribonucleotide reductase N-terminal Band_7 PF01145.25 EFA78749.1 - 1.5e-06 28.3 1.6 1.5e-06 28.3 1.6 2.3 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EFA78749.1 - 0.1 12.3 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family HSP70 PF00012.20 EFA78750.1 - 4.9e-121 404.8 15.5 9.9e-105 351.0 0.0 3.7 3 2 0 3 3 3 2 Hsp70 protein RabGAP-TBC PF00566.18 EFA78750.1 - 2e-55 187.7 3.1 2e-55 187.7 3.1 3.4 5 0 0 5 5 5 1 Rab-GTPase-TBC domain MreB_Mbl PF06723.13 EFA78750.1 - 1.1e-07 31.0 0.0 3e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 MreB/Mbl protein DUF3439 PF11921.8 EFA78750.1 - 0.74 9.8 2.7 2.1 8.3 2.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Acetyltransf_1 PF00583.25 EFA78751.1 - 8.4e-15 55.0 0.0 2.1e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA78751.1 - 1.4e-09 38.3 0.0 8.2e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA78751.1 - 1.6e-09 37.6 0.1 3.1e-09 36.7 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EFA78751.1 - 7.3e-09 35.6 0.0 7.3e-08 32.4 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FNIP PF05725.12 EFA78751.1 - 0.00012 22.2 27.5 1.1 9.4 0.8 7.7 7 3 1 8 8 8 4 FNIP Repeat Acetyltransf_4 PF13420.7 EFA78751.1 - 0.0092 16.1 0.1 0.022 14.9 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain F-box-like PF12937.7 EFA78751.1 - 0.078 12.9 1.7 2.3 8.2 0.3 2.6 2 0 0 2 2 2 0 F-box-like Acetyltransf_8 PF13523.6 EFA78751.1 - 0.081 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain WD40 PF00400.32 EFA78752.1 - 9.7e-24 83.2 12.2 1.5e-05 25.6 0.1 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat Bromodomain PF00439.25 EFA78752.1 - 1.6e-13 50.6 1.7 4.1e-13 49.2 0.1 2.4 2 0 0 2 2 2 1 Bromodomain ANAPC4_WD40 PF12894.7 EFA78752.1 - 6.7e-05 23.1 1.7 7.8 6.9 0.0 5.3 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Auxin_resp PF06507.13 EFA78752.1 - 0.00097 19.4 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 Auxin response factor AAA PF00004.29 EFA78753.1 - 5.7e-99 327.7 0.0 2.1e-49 167.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA78753.1 - 5.5e-25 86.9 8.4 4e-12 45.8 0.4 3.3 2 2 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EFA78753.1 - 2.5e-21 75.6 0.3 7.2e-21 74.2 0.3 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EFA78753.1 - 3.7e-15 56.0 0.0 2.3e-06 27.4 0.0 2.8 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFA78753.1 - 1.3e-13 51.4 0.0 8e-07 29.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFA78753.1 - 7.5e-13 49.2 1.7 0.00017 22.0 0.0 4.1 3 2 0 4 4 3 2 AAA ATPase domain AAA_5 PF07728.14 EFA78753.1 - 1.3e-11 44.7 0.1 4.3e-06 26.8 0.0 3.4 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFA78753.1 - 9.2e-11 42.1 0.0 4.3e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFA78753.1 - 1.7e-10 41.3 0.3 0.0037 17.6 0.1 3.9 2 2 1 3 3 2 2 AAA domain CDC48_2 PF02933.17 EFA78753.1 - 5.8e-10 38.8 0.0 1.2e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_14 PF13173.6 EFA78753.1 - 3.7e-09 36.7 0.0 0.0004 20.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EFA78753.1 - 2.9e-08 33.3 0.0 0.0023 17.2 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EFA78753.1 - 7.7e-08 32.9 0.0 0.013 16.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EFA78753.1 - 1e-07 31.5 0.5 0.0096 15.3 0.1 2.6 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EFA78753.1 - 1.2e-07 32.0 0.0 0.0077 16.6 0.0 2.5 2 0 0 2 2 2 2 RNA helicase Vps4_C PF09336.10 EFA78753.1 - 2.8e-07 30.4 0.5 7.7e-06 25.8 0.1 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase_2 PF01637.18 EFA78753.1 - 5.6e-07 29.7 0.3 0.052 13.5 0.1 3.3 3 1 0 3 3 2 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFA78753.1 - 1.1e-06 28.5 0.1 0.054 13.2 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein Viral_helicase1 PF01443.18 EFA78753.1 - 1.2e-06 28.4 0.0 0.0018 18.0 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 EFA78753.1 - 1.3e-06 28.1 1.6 0.95 9.0 0.0 4.2 2 2 0 4 4 4 1 AAA domain ABC_tran PF00005.27 EFA78753.1 - 1.9e-06 28.4 0.0 0.014 15.9 0.0 2.9 2 1 0 2 2 2 2 ABC transporter Bac_DnaA PF00308.18 EFA78753.1 - 3.3e-06 27.1 0.0 0.018 14.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_28 PF13521.6 EFA78753.1 - 4e-06 27.2 0.0 0.2 11.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 EFA78753.1 - 5.5e-06 25.7 0.1 0.031 13.4 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NACHT PF05729.12 EFA78753.1 - 8.1e-06 25.8 0.1 0.31 10.9 0.0 3.4 3 1 0 4 4 4 2 NACHT domain Zeta_toxin PF06414.12 EFA78753.1 - 9.7e-06 25.0 0.0 0.086 12.1 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_7 PF12775.7 EFA78753.1 - 1.2e-05 25.0 0.1 0.11 12.0 0.0 3.0 3 1 0 3 3 2 2 P-loop containing dynein motor region AAA_17 PF13207.6 EFA78753.1 - 1.5e-05 25.4 0.0 0.19 12.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EFA78753.1 - 2.4e-05 24.1 0.1 0.053 13.2 0.0 2.7 2 1 0 2 2 2 2 AAA domain TsaE PF02367.17 EFA78753.1 - 2.7e-05 24.2 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EFA78753.1 - 3.3e-05 23.7 0.0 0.32 10.7 0.0 3.2 2 2 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 EFA78753.1 - 3.9e-05 23.1 0.2 2.9 7.2 0.0 3.3 3 0 0 3 3 3 1 KaiC Rad17 PF03215.15 EFA78753.1 - 4.1e-05 23.6 0.0 0.38 10.7 0.0 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain NB-ARC PF00931.22 EFA78753.1 - 7.1e-05 22.1 0.0 0.24 10.6 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain DUF815 PF05673.13 EFA78753.1 - 9e-05 21.8 0.0 0.071 12.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 EFA78753.1 - 0.00039 20.5 0.0 0.86 9.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 EFA78753.1 - 0.00043 20.1 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EFA78753.1 - 0.00065 19.8 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cytidylate_kin2 PF13189.6 EFA78753.1 - 0.0025 18.0 0.0 0.54 10.4 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_19 PF13245.6 EFA78753.1 - 0.0052 17.1 0.4 7.5 6.9 0.1 3.4 3 1 1 4 4 2 0 AAA domain NTPase_1 PF03266.15 EFA78753.1 - 0.0055 16.6 0.1 5.3 6.9 0.0 3.5 3 0 0 3 3 3 0 NTPase PhoH PF02562.16 EFA78753.1 - 0.0058 16.1 0.3 1.9 7.9 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein TniB PF05621.11 EFA78753.1 - 0.0076 15.7 0.0 1.7 8.0 0.0 3.5 4 0 0 4 4 4 1 Bacterial TniB protein PduV-EutP PF10662.9 EFA78753.1 - 0.0098 15.6 0.0 3.3 7.5 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SKI PF01202.22 EFA78753.1 - 0.0098 16.0 0.5 6.4 6.9 0.0 2.8 3 0 0 3 3 2 0 Shikimate kinase AAA_11 PF13086.6 EFA78753.1 - 0.011 15.5 0.3 5.2 6.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.6 EFA78753.1 - 0.02 15.4 0.0 12 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EFA78753.1 - 0.022 14.0 0.0 4.9 6.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UFD1 PF03152.14 EFA78753.1 - 0.037 13.5 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 AFG1_ATPase PF03969.16 EFA78753.1 - 0.037 12.9 0.0 4.7 6.0 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase ATP-synt_ab PF00006.25 EFA78753.1 - 0.057 13.1 0.0 11 5.5 0.0 2.6 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain tRNA_lig_kinase PF08303.11 EFA78753.1 - 0.062 13.4 0.0 0.5 10.5 0.0 2.4 2 0 0 2 2 2 0 tRNA ligase kinase domain Adeno_IVa2 PF02456.15 EFA78753.1 - 0.075 11.8 0.0 9.6 4.9 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein Cytidylate_kin PF02224.18 EFA78753.1 - 0.079 12.7 0.0 15 5.2 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase KAP_NTPase PF07693.14 EFA78753.1 - 0.11 11.7 0.1 5.1 6.2 0.0 3.0 2 2 2 4 4 4 0 KAP family P-loop domain AAA_30 PF13604.6 EFA78753.1 - 0.12 12.1 0.1 21 4.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain CDH1_2_SANT_HL1 PF18375.1 EFA78754.1 - 0.012 16.2 0.9 0.018 15.7 0.9 1.2 1 0 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 DUF489 PF04356.12 EFA78757.1 - 0.037 14.0 0.7 0.067 13.2 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF489) Hormone_3 PF00159.18 EFA78757.1 - 0.048 13.7 0.2 0.086 12.9 0.2 1.3 1 0 0 1 1 1 0 Pancreatic hormone peptide SapB_1 PF05184.15 EFA78757.1 - 5.4 7.1 6.9 6.5 6.9 0.1 3.1 3 1 0 3 3 3 0 Saposin-like type B, region 1 Kelch_6 PF13964.6 EFA78759.1 - 4.1e-13 49.1 9.3 7e-08 32.5 0.2 5.1 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EFA78759.1 - 0.00041 19.9 1.7 0.083 12.5 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EFA78759.1 - 0.0051 16.8 2.6 1.3 9.1 0.1 3.2 3 0 0 3 3 3 2 Kelch motif DUF3997 PF13162.6 EFA78759.1 - 0.02 15.2 1.8 0.033 14.5 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3997) Kelch_3 PF13415.6 EFA78759.1 - 0.038 14.3 5.2 11 6.4 0.1 4.5 4 1 1 5 5 5 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA78759.1 - 0.19 11.8 11.7 0.3 11.1 0.2 3.7 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 EFA78759.1 - 0.29 11.2 8.0 42 4.3 0.0 5.5 5 1 0 5 5 5 0 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA78761.1 - 9.3e-16 57.5 1.8 6.4e-11 42.1 0.1 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA78761.1 - 0.00095 18.7 0.2 0.0086 15.6 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 EFA78761.1 - 0.013 15.4 0.1 0.19 11.8 0.0 2.6 2 0 0 2 2 2 0 Kelch motif zf-B_box PF00643.24 EFA78761.1 - 0.017 15.2 12.1 0.034 14.3 12.1 1.5 1 0 0 1 1 1 0 B-box zinc finger Caskin-tail PF16632.5 EFA78761.1 - 1 9.8 3.5 0.82 10.1 0.1 2.6 3 0 0 3 3 3 0 C-terminal region of Caskin Dymeclin PF09742.9 EFA78762.1 - 7.5e-99 331.9 8.8 4.6e-81 273.1 2.0 2.0 2 0 0 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 EFA78762.1 - 7.6e-95 318.7 31.4 3e-73 247.3 8.5 3.5 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein SPX PF03105.19 EFA78762.1 - 1.1 9.2 18.7 0.72 9.7 0.4 2.1 2 0 0 2 2 2 0 SPX domain Ndc1_Nup PF09531.10 EFA78762.1 - 6.2 5.4 27.4 4 6.0 15.3 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DEP PF00610.21 EFA78763.1 - 2.2e-08 34.0 0.0 6.8e-08 32.5 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF4393 PF14337.6 EFA78763.1 - 0.002 18.0 1.3 0.0055 16.5 1.4 1.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4393) CCSAP PF15748.5 EFA78763.1 - 0.038 14.2 12.0 0.65 10.1 0.1 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF2868 PF11067.8 EFA78763.1 - 0.063 12.8 0.8 0.1 12.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Mucin PF01456.17 EFA78763.1 - 0.35 10.8 31.7 0.72 9.8 31.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Menin PF05053.13 EFA78763.1 - 3.7 5.8 9.3 5.1 5.3 9.3 1.2 1 0 0 1 1 1 0 Menin UbiA PF01040.18 EFA78766.1 - 3.5e-43 147.7 12.9 3.5e-43 147.7 12.9 2.4 2 1 0 2 2 2 1 UbiA prenyltransferase family Lung_7-TM_R PF06814.13 EFA78767.1 - 0.00011 21.6 2.1 0.00019 20.8 2.1 1.4 1 0 0 1 1 1 1 Lung seven transmembrane receptor Pkinase PF00069.25 EFA78768.1 - 6.4e-36 124.1 0.0 1.5e-35 122.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain PH PF00169.29 EFA78768.1 - 6.2e-20 71.7 0.3 1.3e-19 70.7 0.3 1.6 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 EFA78768.1 - 6.1e-15 55.2 0.0 9.7e-15 54.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 EFA78768.1 - 1e-07 32.0 0.4 2.2e-07 30.9 0.4 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA78768.1 - 8.3e-07 29.4 1.3 8.3e-05 23.0 1.3 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EFA78768.1 - 6.7e-05 23.2 0.4 0.00034 21.0 0.4 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFA78768.1 - 0.00013 22.2 0.1 0.0002 21.6 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain Pkinase_C PF00433.24 EFA78768.1 - 0.00021 21.9 0.2 0.00038 21.1 0.2 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain PH_6 PF15406.6 EFA78768.1 - 0.0028 17.9 0.0 0.0051 17.1 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Pkinase_fungal PF17667.1 EFA78768.1 - 0.052 12.3 0.0 0.081 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ribosomal_S10 PF00338.22 EFA78768.1 - 0.089 13.0 0.1 14 6.0 0.1 2.3 1 1 1 2 2 2 0 Ribosomal protein S10p/S20e RabGAP-TBC PF00566.18 EFA78769.1 - 4.2e-54 183.5 0.5 9.7e-54 182.3 0.1 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain F-box-like PF12937.7 EFA78769.1 - 0.00031 20.6 1.0 0.0031 17.4 0.8 2.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA78769.1 - 0.00067 19.5 0.2 0.0018 18.1 0.2 1.7 1 0 0 1 1 1 1 F-box domain EGF_alliinase PF04863.13 EFA78769.1 - 0.026 14.9 0.3 0.046 14.1 0.3 1.4 1 0 0 1 1 1 0 Alliinase EGF-like domain PRIMA1 PF16101.5 EFA78769.1 - 0.078 13.0 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Macoilin PF09726.9 EFA78769.1 - 0.11 11.0 3.9 0.2 10.2 3.9 1.3 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 EFA78769.1 - 2 8.3 10.0 0.095 12.6 4.3 1.6 2 0 0 2 2 2 0 SPX domain AAA PF00004.29 EFA78770.1 - 3.2e-41 140.9 0.0 5.9e-41 140.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA78770.1 - 1.7e-10 40.6 0.1 3.7e-10 39.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFA78770.1 - 2.5e-05 24.3 0.0 0.00011 22.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFA78770.1 - 0.00028 21.2 0.0 0.024 14.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 EFA78770.1 - 0.00056 20.1 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EFA78770.1 - 0.0011 18.2 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EFA78770.1 - 0.0014 19.1 0.1 0.013 15.9 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EFA78770.1 - 0.0035 17.7 0.0 0.0088 16.4 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 EFA78770.1 - 0.0041 17.3 0.0 0.0073 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFA78770.1 - 0.0043 16.8 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EFA78770.1 - 0.017 14.7 0.0 0.044 13.3 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFA78770.1 - 0.022 14.1 0.0 0.047 13.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EFA78770.1 - 0.029 13.6 0.0 0.06 12.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 EFA78770.1 - 0.033 14.4 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EFA78770.1 - 0.044 13.6 0.0 0.095 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFA78770.1 - 0.044 13.5 0.2 0.27 11.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFA78770.1 - 0.086 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 EFA78770.1 - 0.12 12.3 0.0 11 5.8 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFA78770.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Utp21 PF04192.12 EFA78771.1 - 7e-62 209.0 17.7 7e-62 209.0 17.7 2.3 2 1 0 2 2 2 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EFA78771.1 - 1.4e-16 60.6 6.2 0.27 12.2 0.1 10.2 11 0 0 11 11 11 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78771.1 - 1.2e-10 41.5 2.0 0.00026 21.2 0.1 5.6 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EFA78771.1 - 0.0002 19.9 0.1 0.016 13.5 0.0 2.6 2 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 EFA78771.1 - 0.0018 18.2 0.0 0.38 10.8 0.0 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Utp12 PF04003.12 EFA78771.1 - 0.049 14.0 0.1 0.093 13.0 0.1 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family HSP33 PF01430.19 EFA78772.1 - 2.9e-50 171.2 0.1 3.7e-50 170.8 0.1 1.1 1 0 0 1 1 1 1 Hsp33 protein Kelch_6 PF13964.6 EFA78773.1 - 2.5e-05 24.4 0.7 0.16 12.3 0.0 3.1 3 1 0 3 3 3 2 Kelch motif OLF PF02191.16 EFA78773.1 - 0.0029 17.2 1.1 0.0035 16.9 1.1 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Mucin_bdg PF03272.13 EFA78773.1 - 0.0078 16.2 0.3 0.01 15.9 0.3 1.3 1 0 0 1 1 1 1 Putative mucin or carbohydrate-binding module Kelch_2 PF07646.15 EFA78773.1 - 0.15 12.0 0.2 22 5.2 0.0 2.7 2 0 0 2 2 2 0 Kelch motif EGF_2 PF07974.13 EFA78774.1 - 3e-06 27.5 39.2 0.0016 18.8 13.5 3.3 3 0 0 3 3 3 2 EGF-like domain EB PF01683.18 EFA78774.1 - 0.017 15.4 11.3 0.82 10.0 1.5 2.8 2 0 0 2 2 2 0 EB module EF-hand_12 PF17901.1 EFA78774.1 - 0.48 10.9 8.4 8.8 6.9 1.1 2.8 2 0 0 2 2 2 0 EF-hand fold domain Pico_P1A PF02226.16 EFA78774.1 - 2.1 8.4 4.7 0.97 9.5 0.3 2.8 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) DUF1672 PF07901.11 EFA78774.1 - 8 5.7 12.8 0.11 11.8 0.3 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1672) DNA_pol_A_exo1 PF01612.20 EFA78775.1 - 3.8e-17 62.6 0.0 7.3e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease RR_TM4-6 PF06459.12 EFA78775.1 - 0.4 10.5 12.5 0.028 14.2 7.1 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.5 EFA78775.1 - 0.58 10.0 16.5 0.049 13.4 6.4 3.0 3 0 0 3 3 3 0 Coilin N-terminus CobT PF06213.12 EFA78775.1 - 0.64 9.4 7.2 1.6 8.0 6.1 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT RRN3 PF05327.11 EFA78775.1 - 2.4 6.6 11.1 0.3 9.6 6.8 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EFA78775.1 - 4.2 5.5 12.4 1.1 7.5 8.1 2.1 2 0 0 2 2 2 0 CDC45-like protein ALMT PF11744.8 EFA78775.1 - 4.5 6.0 8.5 1.9 7.3 4.7 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter RP-C_C PF11800.8 EFA78775.1 - 9.3 6.3 7.9 17 5.4 3.8 2.5 2 0 0 2 2 2 0 Replication protein C C-terminal region Ank_2 PF12796.7 EFA78776.1 - 4.5e-09 36.8 17.5 0.0023 18.5 0.2 6.3 3 2 3 7 7 7 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78776.1 - 0.00045 20.7 7.2 0.092 13.4 0.1 6.1 6 3 2 8 8 8 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78776.1 - 0.024 15.2 18.2 45 5.1 0.1 9.6 10 1 1 11 11 11 0 Ankyrin repeat Ank_5 PF13857.6 EFA78776.1 - 1.2 9.5 7.0 11 6.4 0.1 5.4 4 1 2 6 6 6 0 Ankyrin repeats (many copies) EGF_2 PF07974.13 EFA78777.1 - 1.4 9.3 11.1 3.1 8.3 11.1 1.6 1 0 0 1 1 1 0 EGF-like domain Lectin_C PF00059.21 EFA78777.1 - 1.7 9.4 13.4 1.3 9.8 0.1 4.0 4 1 0 4 4 4 0 Lectin C-type domain Cob_adeno_trans PF01923.18 EFA78778.1 - 0.055 13.6 0.0 0.058 13.5 0.0 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase 7tm_3 PF00003.22 EFA78780.1 - 0.007 16.1 5.4 0.0087 15.8 5.4 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR TMEM43 PF07787.12 EFA78780.1 - 0.16 11.4 0.6 0.21 10.9 0.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 DUF5336 PF17270.2 EFA78780.1 - 0.24 11.0 5.1 0.069 12.8 1.3 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5336) ESSS PF10183.9 EFA78780.1 - 0.97 9.7 0.0 0.97 9.7 0.0 2.0 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Pex14_N PF04695.13 EFA78780.1 - 5.4 7.6 13.2 8.9 7.0 13.2 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3169 PF11368.8 EFA78781.1 - 0.00057 19.5 1.0 0.00072 19.2 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) Amastin PF07344.11 EFA78781.1 - 0.031 14.1 2.4 0.053 13.4 2.4 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein TMEM43 PF07787.12 EFA78781.1 - 0.13 11.6 1.0 0.18 11.1 1.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 SUR7 PF06687.12 EFA78781.1 - 0.26 10.9 9.8 0.62 9.6 8.5 1.8 1 1 1 2 2 2 0 SUR7/PalI family Pex14_N PF04695.13 EFA78781.1 - 0.59 10.8 8.5 1.1 9.9 8.5 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spore_GerAC PF05504.11 EFA78782.1 - 0.29 11.3 7.2 0.31 11.2 7.2 1.2 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal TcdA_TcdB_pore PF12920.7 EFA78782.1 - 3.3 5.8 12.5 3.4 5.8 12.5 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain FNIP PF05725.12 EFA78783.1 - 1.3e-09 38.0 11.7 1.1 9.5 0.0 7.8 6 1 1 7 7 7 6 FNIP Repeat F-box_5 PF18511.1 EFA78783.1 - 0.077 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 F-box Helo_like_N PF17111.5 EFA78784.1 - 0.078 12.3 0.4 0.19 11.0 0.4 1.6 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins FNIP PF05725.12 EFA78785.1 - 3.5e-07 30.3 26.4 1.5 9.0 0.1 9.2 5 3 4 9 9 9 8 FNIP Repeat F-box_5 PF18511.1 EFA78785.1 - 0.002 17.6 0.0 0.0039 16.7 0.0 1.4 1 0 0 1 1 1 1 F-box BCL_N PF04714.13 EFA78786.1 - 0.00014 21.8 0.5 0.00014 21.8 0.5 2.1 2 0 0 2 2 2 1 BCL7, N-terminal conserver region Spy1 PF11357.8 EFA78787.1 - 8.5e-10 39.0 4.6 1.6e-05 25.2 0.8 2.5 1 1 1 2 2 2 2 Cell cycle regulatory protein Sugar_transport PF06800.12 EFA78787.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Sugar transport protein Hemocyanin_N PF03722.14 EFA78787.1 - 0.87 10.1 6.1 0.85 10.1 2.9 2.3 2 0 0 2 2 2 0 Hemocyanin, all-alpha domain Transket_pyr PF02779.24 EFA78789.1 - 3.7e-58 196.1 0.0 6.6e-58 195.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EFA78789.1 - 1.8e-51 173.8 0.0 3.7e-51 172.8 0.0 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EFA78789.1 - 2.3e-45 154.8 0.0 3.7e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Uma2 PF05685.12 EFA78790.1 - 0.05 13.1 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative restriction endonuclease PEX11 PF05648.14 EFA78791.1 - 0.38 10.2 0.0 0.38 10.2 0.0 2.9 3 1 0 3 3 3 0 Peroxisomal biogenesis factor 11 (PEX11) SAC3_GANP PF03399.16 EFA78792.1 - 7.5e-27 94.5 8.1 6.1e-25 88.2 8.1 2.1 1 1 0 1 1 1 1 SAC3/GANP family Kelch_6 PF13964.6 EFA78793.1 - 1.6e-15 56.7 8.0 2.4e-11 43.5 0.0 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA78793.1 - 0.0056 16.2 0.4 0.044 13.4 0.0 2.6 2 0 0 2 2 2 1 Kelch motif zf-B_box PF00643.24 EFA78793.1 - 0.015 15.5 14.3 0.036 14.2 14.3 1.6 1 0 0 1 1 1 0 B-box zinc finger Kelch_4 PF13418.6 EFA78793.1 - 0.027 14.5 0.7 0.93 9.6 0.0 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA78793.1 - 0.51 10.4 2.6 1.2 9.2 0.2 2.6 2 0 0 2 2 2 0 Kelch motif NHL PF01436.21 EFA78793.1 - 2.4 8.4 6.0 5.1 7.3 0.5 3.0 2 0 0 2 2 2 0 NHL repeat Kelch_6 PF13964.6 EFA78794.1 - 3.9e-20 71.4 4.5 2.8e-11 43.3 0.1 5.1 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA78794.1 - 3.4e-05 23.3 0.4 0.0029 17.2 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EFA78794.1 - 5.1e-05 23.2 3.9 1 9.4 0.0 4.5 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA78794.1 - 0.012 15.6 1.8 0.22 11.6 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 EFA78794.1 - 0.078 13.3 2.0 19 5.7 0.1 4.5 4 1 1 5 5 5 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA78794.1 - 2.4 8.2 7.8 0.41 10.7 0.1 3.1 3 0 0 3 3 3 0 Kelch motif DHHC PF01529.20 EFA78795.1 - 9.6e-33 113.1 6.1 9.6e-33 113.1 6.1 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase zf-ribbon_3 PF13248.6 EFA78795.1 - 0.29 10.6 3.8 0.64 9.5 3.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain IPP-2 PF04979.14 EFA78796.1 - 1.3e-16 61.5 40.6 1.3e-16 61.5 40.6 4.8 2 2 2 4 4 4 1 Protein phosphatase inhibitor 2 (IPP-2) Mucin PF01456.17 EFA78796.1 - 0.26 11.3 20.4 0.28 11.1 8.8 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein BAR PF03114.18 EFA78797.1 - 4.6e-08 33.0 1.2 7.6e-08 32.3 1.2 1.4 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EFA78797.1 - 6e-05 22.9 0.7 8.6e-05 22.3 0.7 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Herpes_TK PF00693.18 EFA78797.1 - 0.077 12.2 0.1 3.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus CBS PF00571.28 EFA78798.1 - 5e-12 46.1 4.1 9.3e-05 22.8 0.2 3.4 3 0 0 3 3 3 3 CBS domain RGS PF00615.19 EFA78799.1 - 2.2e-44 150.5 22.1 1.1e-18 67.6 1.1 4.5 5 0 0 5 5 5 3 Regulator of G protein signaling domain RGS-like PF09128.11 EFA78799.1 - 4.6e-06 26.5 7.3 0.063 13.0 0.1 3.6 3 0 0 3 3 3 3 Regulator of G protein signalling-like domain HMGL-like PF00682.19 EFA78799.1 - 0.18 11.4 0.0 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 HMGL-like tRNA-synt_His PF13393.6 EFA78801.1 - 1.4e-35 123.1 0.0 4.8e-35 121.3 0.0 1.9 2 1 0 2 2 2 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 EFA78801.1 - 2.7e-16 60.1 0.0 6.9e-16 58.7 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFA78801.1 - 3.8e-10 39.8 0.2 9.4e-10 38.5 0.2 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.20 EFA78801.1 - 0.0069 15.9 0.0 0.052 13.0 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) DAGK_cat PF00781.24 EFA78801.1 - 0.044 13.4 0.0 4.7 6.9 0.0 2.5 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Cytomega_gL PF01801.16 EFA78801.1 - 0.054 12.9 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein L tRNA-synt_2 PF00152.20 EFA78801.1 - 0.063 12.3 1.4 1.4 7.9 0.8 2.6 2 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) TPR_2 PF07719.17 EFA78803.1 - 1.8e-05 24.5 10.5 0.017 15.2 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA78803.1 - 2.9e-05 24.1 0.0 0.02 15.2 0.0 4.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA78803.1 - 0.00087 19.0 0.0 8.2 6.4 0.0 4.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78803.1 - 0.0023 18.0 2.2 7.5 7.1 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78803.1 - 0.008 16.9 0.4 63 4.8 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78803.1 - 0.012 15.9 9.8 20 5.6 0.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat PuR_N PF09182.10 EFA78803.1 - 0.041 13.8 0.1 12 5.9 0.0 3.0 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal TPR_7 PF13176.6 EFA78803.1 - 0.061 13.4 0.2 2.1 8.6 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA78803.1 - 0.24 11.9 2.5 16 6.1 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFA78803.1 - 1 9.5 3.0 0.77 9.9 0.6 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat NDUFA12 PF05071.16 EFA78804.1 - 8.1e-26 90.7 0.4 1e-25 90.3 0.4 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 TIG PF01833.24 EFA78805.1 - 0.00024 21.1 1.6 0.00024 21.1 1.6 8.1 9 1 0 9 9 9 4 IPT/TIG domain Neurensin PF14927.6 EFA78805.1 - 0.065 12.9 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 Neurensin DUF3432 PF11914.8 EFA78805.1 - 2 8.7 9.0 0.4 11.0 2.5 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3432) EGF_Tenascin PF18720.1 EFA78805.1 - 2.2 8.4 8.2 6.1 7.0 8.2 1.8 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 EFA78805.1 - 6.9 7.1 15.2 13 6.2 15.2 1.5 1 0 0 1 1 1 0 EGF-like domain AAA PF00004.29 EFA78807.1 - 7.1e-43 146.2 0.0 1.3e-42 145.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Kelch_6 PF13964.6 EFA78807.1 - 8.4e-12 44.9 0.2 1.4e-07 31.6 0.0 2.6 2 0 0 2 2 2 2 Kelch motif AAA_lid_3 PF17862.1 EFA78807.1 - 6e-09 35.6 0.7 1.3e-08 34.5 0.7 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFA78807.1 - 4.1e-07 30.1 0.1 4.9e-06 26.6 0.1 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA78807.1 - 4.8e-07 30.3 0.0 0.00034 21.1 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFA78807.1 - 3.1e-06 27.0 0.0 8e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFA78807.1 - 3.2e-05 24.1 0.0 6.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFA78807.1 - 0.0001 22.6 0.0 0.008 16.5 0.0 2.5 1 1 1 2 2 2 1 AAA domain Prot_ATP_ID_OB PF16450.5 EFA78807.1 - 0.00019 21.3 0.0 0.00042 20.2 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_18 PF13238.6 EFA78807.1 - 0.00091 19.8 0.1 0.0056 17.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFA78807.1 - 0.0013 18.2 0.0 0.003 17.1 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EFA78807.1 - 0.0027 18.1 0.0 0.0074 16.7 0.0 1.8 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EFA78807.1 - 0.0028 16.9 0.0 0.0053 16.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EFA78807.1 - 0.0038 16.4 0.0 0.0069 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EFA78807.1 - 0.0038 17.0 0.0 0.0095 15.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein TsaE PF02367.17 EFA78807.1 - 0.0045 17.0 0.0 0.0092 16.0 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EFA78807.1 - 0.0049 16.9 0.0 0.015 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EFA78807.1 - 0.0053 16.2 0.0 0.0099 15.3 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFA78807.1 - 0.0079 16.4 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFA78807.1 - 0.01 15.5 0.0 0.035 13.8 0.0 1.9 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 EFA78807.1 - 0.013 15.4 0.0 0.035 14.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 EFA78807.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RecU PF03838.14 EFA78807.1 - 0.018 15.0 0.4 0.037 14.0 0.4 1.5 1 0 0 1 1 1 0 Recombination protein U ATPase_2 PF01637.18 EFA78807.1 - 0.026 14.5 0.1 0.098 12.6 0.0 2.0 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EFA78807.1 - 0.036 14.0 0.0 0.081 12.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EFA78807.1 - 0.052 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EFA78807.1 - 0.062 12.6 0.0 0.22 10.8 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.6 EFA78807.1 - 0.072 13.3 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA78807.1 - 0.087 13.3 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Kelch_4 PF13418.6 EFA78807.1 - 0.093 12.8 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain PhoH PF02562.16 EFA78807.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 EFA78807.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFA78807.1 - 0.18 11.6 0.8 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Kelch_1 PF01344.25 EFA78807.1 - 0.18 11.4 0.1 0.53 9.9 0.0 1.8 2 0 0 2 2 1 0 Kelch motif DUF1043 PF06295.12 EFA78807.1 - 1 9.4 7.3 1.7 8.6 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Kelch_6 PF13964.6 EFA78808.1 - 6.6e-15 54.8 1.8 3.5e-09 36.6 0.0 4.5 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA78808.1 - 0.04 13.5 0.1 0.75 9.4 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 EFA78808.1 - 0.086 12.9 0.7 7.4 6.7 0.1 3.0 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 EFA78809.1 - 3.3e-13 49.4 0.3 2.8e-08 33.7 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFA78809.1 - 0.0004 19.9 0.1 0.0052 16.3 0.0 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EFA78809.1 - 0.00076 19.4 0.3 3.7 7.6 0.1 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain zf-B_box PF00643.24 EFA78809.1 - 0.0077 16.4 18.0 0.026 14.7 18.0 1.8 1 0 0 1 1 1 1 B-box zinc finger Kelch_5 PF13854.6 EFA78809.1 - 0.14 12.1 5.0 2.8 8.0 0.2 3.3 3 0 0 3 3 3 0 Kelch motif Corazonin PF17308.2 EFA78809.1 - 0.23 11.8 8.5 0.38 11.1 8.5 1.3 1 0 0 1 1 1 0 Pro-corazonin DDE_Tnp_4 PF13359.6 EFA78810.1 - 0.0042 16.8 0.0 0.0044 16.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Uma2 PF05685.12 EFA78811.1 - 0.0002 20.9 0.0 0.00023 20.8 0.0 1.1 1 0 0 1 1 1 1 Putative restriction endonuclease Mt_ATP-synt_B PF05405.14 EFA78811.1 - 0.18 11.4 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SAP PF02037.27 EFA78814.1 - 0.00033 20.3 0.1 0.0038 16.9 0.0 2.3 2 0 0 2 2 2 1 SAP domain NPR2 PF06218.11 EFA78815.1 - 6.6e-93 311.9 14.5 3.6e-77 260.0 13.3 3.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 NPR3 PF03666.13 EFA78815.1 - 8.6e-07 28.1 0.4 0.02 13.7 0.1 3.1 3 0 0 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.12 EFA78815.1 - 0.02 15.3 0.2 0.11 13.0 0.1 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Kelch_6 PF13964.6 EFA78816.1 - 0.00061 20.0 1.4 3 8.3 0.0 4.3 3 1 0 3 3 3 2 Kelch motif MIEAP PF16026.5 EFA78817.1 - 0.051 13.8 8.8 0.93 9.7 1.9 2.1 2 0 0 2 2 2 0 Mitochondria-eating protein AAA_11 PF13086.6 EFA78817.1 - 9.6 5.9 13.1 0.93 9.2 5.2 2.0 1 1 1 2 2 2 0 AAA domain GTP_EFTU PF00009.27 EFA78818.1 - 2.2e-37 128.5 0.1 2.6e-37 128.3 0.1 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA78818.1 - 6.9e-06 26.1 0.0 2.4e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFA78818.1 - 0.019 15.0 0.0 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 Dynamin family SRPRB PF09439.10 EFA78818.1 - 0.024 14.1 0.1 0.65 9.4 0.0 2.1 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFA78818.1 - 0.036 13.8 0.1 7.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FNIP PF05725.12 EFA78819.1 - 2.9e-70 232.2 18.2 2.5e-16 59.6 0.2 7.8 2 2 1 7 7 7 5 FNIP Repeat zf-B_box PF00643.24 EFA78819.1 - 0.01 16.0 10.8 0.017 15.3 10.8 1.3 1 0 0 1 1 1 1 B-box zinc finger Glyco_hydro_65C PF03633.15 EFA78819.1 - 0.33 10.9 6.6 82 3.2 0.0 6.1 8 1 0 8 8 8 0 Glycosyl hydrolase family 65, C-terminal domain PMSR PF01625.21 EFA78819.1 - 6.2 7.0 9.7 10 6.3 1.4 3.0 3 0 0 3 3 3 0 Peptide methionine sulfoxide reductase HLH PF00010.26 EFA78820.1 - 1.8 8.6 6.8 0.16 11.9 1.2 2.1 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Kelch_6 PF13964.6 EFA78821.1 - 1.6e-14 53.6 4.5 1.4e-07 31.5 0.1 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFA78821.1 - 0.0025 17.8 2.8 6 7.0 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA78821.1 - 0.0029 17.2 2.7 0.058 13.0 0.0 3.3 2 1 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 EFA78821.1 - 0.01 15.8 0.1 3.3 7.8 0.0 2.8 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 EFA78821.1 - 0.042 13.9 2.0 0.22 11.6 0.2 2.5 2 0 0 2 2 2 0 Kelch motif zf-B_box PF00643.24 EFA78821.1 - 0.49 10.6 16.7 0.056 13.6 11.9 1.8 2 0 0 2 2 2 0 B-box zinc finger FNIP PF05725.12 EFA78822.1 - 4.5e-46 154.7 25.2 4.6e-15 55.5 1.0 7.4 5 2 1 7 7 7 4 FNIP Repeat Pkinase PF00069.25 EFA78822.1 - 1.2e-29 103.5 1.9 1.2e-29 103.5 1.9 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78822.1 - 2.4e-11 43.4 0.1 8.8e-10 38.3 0.1 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA78822.1 - 0.046 13.6 0.0 2.5 7.9 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Glyco_hydro_65C PF03633.15 EFA78822.1 - 0.051 13.5 1.1 91 3.1 0.0 4.9 5 0 0 5 5 5 0 Glycosyl hydrolase family 65, C-terminal domain zf-B_box PF00643.24 EFA78822.1 - 0.085 13.0 7.3 0.18 12.0 7.3 1.5 1 0 0 1 1 1 0 B-box zinc finger Kelch_6 PF13964.6 EFA78825.1 - 1e-09 38.3 6.2 0.0028 17.9 0.1 4.3 5 0 0 5 5 5 3 Kelch motif DUF1451 PF07295.11 EFA78825.1 - 0.05 13.6 2.9 0.065 13.3 1.8 1.8 1 1 0 1 1 1 0 Zinc-ribbon containing domain Kelch_5 PF13854.6 EFA78825.1 - 0.4 10.7 1.9 0.64 10.1 0.1 2.4 2 0 0 2 2 2 0 Kelch motif Fibin PF15819.5 EFA78825.1 - 2.1 8.1 8.0 2.9 7.6 3.8 2.6 1 1 1 2 2 2 0 Fin bud initiation factor homologue DnaI_N PF07319.11 EFA78825.1 - 7.2 7.4 12.8 0.54 11.0 0.7 3.5 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus ALMT PF11744.8 EFA78825.1 - 8.8 5.0 15.7 3.2 6.5 12.8 1.5 1 1 0 1 1 1 0 Aluminium activated malate transporter FNIP PF05725.12 EFA78826.1 - 2.3e-66 219.7 33.8 1.1e-14 54.3 4.0 6.8 3 2 5 8 8 8 6 FNIP Repeat Pkinase PF00069.25 EFA78826.1 - 5.8e-33 114.4 0.9 5.8e-33 114.4 0.9 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA78826.1 - 5e-11 42.4 0.0 3.1e-07 30.0 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFA78826.1 - 0.0031 17.5 0.0 0.21 11.5 0.2 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family zf-B_box PF00643.24 EFA78826.1 - 0.015 15.4 12.7 0.03 14.5 12.7 1.5 1 0 0 1 1 1 0 B-box zinc finger ORF6C PF10552.9 EFA78826.1 - 1.7 8.8 7.8 0.13 12.3 1.9 2.2 2 0 0 2 2 2 0 ORF6C domain zf-BED PF02892.15 EFA78827.1 - 2.8 8.0 14.7 0.64 10.1 9.7 2.4 2 1 1 3 3 3 0 BED zinc finger Annexin PF00191.20 EFA78828.1 - 5.7e-84 276.2 13.4 9.7e-25 86.4 0.1 5.2 5 0 0 5 5 5 5 Annexin DUF2312 PF10073.9 EFA78828.1 - 0.069 12.8 0.5 12 5.6 0.1 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) HMGL-like PF00682.19 EFA78829.1 - 3.2e-57 194.1 0.0 3.7e-57 193.9 0.0 1.0 1 0 0 1 1 1 1 HMGL-like Spermine_synth PF01564.17 EFA78830.1 - 3.1e-67 225.7 0.0 5.3e-67 224.9 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EFA78830.1 - 1.5e-24 85.6 0.2 2.4e-24 84.9 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EFA78830.1 - 0.00037 21.1 0.0 0.00075 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA78830.1 - 0.062 14.1 0.0 0.14 12.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EFA78830.1 - 0.074 13.0 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FeS_assembly_P PF01883.19 EFA78831.1 - 3.2e-14 52.8 0.0 5e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Kelch_6 PF13964.6 EFA78832.1 - 7.4e-05 22.9 5.2 0.16 12.3 0.2 4.7 4 0 0 4 4 4 2 Kelch motif zf-B_box PF00643.24 EFA78832.1 - 0.00012 22.1 10.3 0.0004 20.5 10.3 1.9 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA78833.1 - 2.8e-10 40.1 2.3 7.8e-06 26.0 0.1 4.3 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EFA78833.1 - 0.004 17.1 0.2 0.87 9.7 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EFA78833.1 - 0.0089 16.0 1.3 1.4 9.0 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Nup54 PF13874.6 EFA78833.1 - 0.015 15.4 0.1 0.058 13.5 0.1 2.1 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 zf-B_box PF00643.24 EFA78833.1 - 0.047 13.8 14.7 0.098 12.8 14.7 1.5 1 0 0 1 1 1 0 B-box zinc finger Ku_C PF03730.14 EFA78833.1 - 0.061 14.0 1.4 0.23 12.2 1.4 2.0 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm BRCC36_C PF18110.1 EFA78833.1 - 0.073 13.2 0.7 0.22 11.7 0.7 1.8 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain Kelch_1 PF01344.25 EFA78833.1 - 0.12 12.0 0.3 0.62 9.7 0.0 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 EFA78833.1 - 0.15 12.1 6.2 0.85 9.7 0.1 3.2 3 0 0 3 3 3 0 Kelch motif Pox_EPC_I2-L1 PF12575.8 EFA78833.1 - 0.25 11.6 1.3 0.91 9.8 1.3 2.0 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 zf-UBP PF02148.19 EFA78833.1 - 0.33 11.3 7.8 0.85 10.0 5.9 2.5 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Ank_2 PF12796.7 EFA78834.1 - 0.00012 22.6 0.0 6.1 7.5 0.0 4.9 3 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78834.1 - 0.017 15.4 0.0 1.2e+02 3.2 0.0 4.4 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA78834.1 - 0.023 15.3 0.5 32 5.3 0.0 5.1 4 1 1 5 5 5 0 Ankyrin repeats (many copies) Kelch_6 PF13964.6 EFA78836.1 - 5.3e-12 45.6 1.1 1.8e-06 28.0 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EFA78836.1 - 0.0055 16.7 0.3 0.017 15.1 0.3 1.8 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 EFA78836.1 - 0.009 15.6 0.2 0.031 13.9 0.1 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 EFA78836.1 - 0.096 12.7 0.2 0.4 10.7 0.2 2.2 1 1 0 1 1 1 0 Kelch motif Baculo_PEP_C PF04513.12 EFA78836.1 - 0.1 12.6 4.7 0.37 10.8 4.6 2.0 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Kelch_4 PF13418.6 EFA78836.1 - 0.15 12.1 1.3 12 6.0 0.0 3.7 4 0 0 4 4 4 0 Galactose oxidase, central domain PFEMP PF03011.15 EFA78836.1 - 0.67 10.6 5.6 0.15 12.7 1.4 2.0 2 0 0 2 2 2 0 PFEMP DBL domain Kelch_6 PF13964.6 EFA78837.1 - 5.9e-06 26.4 0.5 6e-05 23.2 0.5 2.6 1 1 0 1 1 1 1 Kelch motif zf-B_box PF00643.24 EFA78837.1 - 8.3e-05 22.7 26.0 0.02 15.0 11.7 2.4 2 0 0 2 2 2 2 B-box zinc finger Kelch_1 PF01344.25 EFA78837.1 - 0.019 14.5 0.1 0.065 12.8 0.1 1.9 1 0 0 1 1 1 0 Kelch motif FYVE PF01363.21 EFA78837.1 - 0.57 10.4 6.3 1.7 8.8 1.2 2.5 2 0 0 2 2 2 0 FYVE zinc finger NYD-SP28_assoc PF14775.6 EFA78837.1 - 1 9.5 5.7 1 9.5 0.8 3.0 2 1 0 2 2 2 0 Sperm tail C-terminal domain Kelch_6 PF13964.6 EFA78838.1 - 2.2e-08 34.1 0.7 0.00072 19.8 0.1 3.2 3 0 0 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA78838.1 - 2.6e-05 24.3 8.8 7.8e-05 22.7 8.8 1.8 1 0 0 1 1 1 1 B-box zinc finger COMPASS-Shg1 PF05205.12 EFA78838.1 - 0.0028 18.3 3.8 0.0028 18.3 3.8 2.2 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 Spidroin_N PF16763.5 EFA78838.1 - 0.15 12.1 1.9 3 7.9 0.9 2.4 2 0 0 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term ArfGap PF01412.18 EFA78838.1 - 7.8 6.6 10.7 1 9.4 1.6 3.0 2 1 1 3 3 3 0 Putative GTPase activating protein for Arf WD40 PF00400.32 EFA78839.1 - 4.5e-38 128.6 20.0 1.2e-08 35.4 0.1 6.5 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 EFA78839.1 - 5.7e-12 45.6 7.6 1.7e-08 34.2 6.5 3.2 1 1 1 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 EFA78839.1 - 1.1e-11 44.9 2.4 0.31 11.4 0.0 5.5 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA78839.1 - 1.9e-05 24.7 0.6 2.5 8.2 0.0 4.9 3 2 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 EFA78839.1 - 0.0053 15.1 2.1 3.1 6.0 0.1 3.2 3 1 1 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz PQQ PF01011.21 EFA78839.1 - 0.11 12.5 0.1 0.84 9.7 0.0 2.6 4 0 0 4 4 4 0 PQQ enzyme repeat CUE PF02845.16 EFA78840.1 - 0.075 12.8 5.9 13 5.6 0.1 4.8 5 0 0 5 5 5 0 CUE domain Mon2_C PF16206.5 EFA78841.1 - 7.5e-75 252.6 9.8 6.8e-44 150.2 1.7 3.6 2 1 0 2 2 2 2 C-terminal region of Mon2 protein DCB PF16213.5 EFA78841.1 - 2.4e-56 190.2 8.3 2.4e-56 190.2 8.3 4.7 5 0 0 5 5 5 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EFA78841.1 - 4.1e-25 88.5 17.1 3e-14 53.2 0.3 5.9 4 1 1 5 5 5 3 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EFA78841.1 - 1.7e-10 40.6 0.8 1.7e-10 40.6 0.8 5.5 5 1 1 6 6 6 1 Domain of unknown function (DUF1981) Mad3_BUB1_I PF08311.12 EFA78841.1 - 0.95 9.5 3.8 2.6 8.1 0.2 3.2 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 Calreticulin PF00262.18 EFA78842.1 - 1.1e-141 471.9 14.2 1.6e-141 471.4 14.2 1.2 1 0 0 1 1 1 1 Calreticulin family FAM176 PF14851.6 EFA78842.1 - 0.22 11.2 3.5 0.14 11.8 0.7 2.1 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.5 EFA78842.1 - 0.29 12.1 0.2 0.29 12.1 0.2 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 EFA78842.1 - 1 8.1 2.8 1.5 7.5 2.8 1.3 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 EFA78842.1 - 2.6 7.4 8.4 0.32 10.3 3.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Kelch_3 PF13415.6 EFA78843.1 - 4.6e-16 58.7 6.1 0.0095 16.2 0.1 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA78843.1 - 1.2e-13 50.9 10.1 5.2e-08 32.8 0.1 5.5 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA78843.1 - 1.2e-12 47.7 11.4 0.0043 17.3 0.0 6.2 6 1 1 7 7 7 4 Kelch motif Kelch_5 PF13854.6 EFA78843.1 - 1.4e-11 44.1 0.3 0.014 15.4 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EFA78843.1 - 9.1e-11 41.2 3.6 0.0022 17.5 0.2 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFA78843.1 - 0.28 11.3 16.5 6.9 6.8 0.3 5.8 5 2 0 5 5 5 0 Kelch motif H_lectin PF09458.10 EFA78844.1 - 6e-18 64.8 0.3 8.5e-18 64.3 0.3 1.2 1 0 0 1 1 1 1 H-type lectin domain CLASP_N PF12348.8 EFA78845.1 - 1.8e-32 112.8 4.0 1.8e-32 112.8 4.0 2.5 2 0 0 2 2 2 1 CLASP N terminal ApoB100_C PF12491.8 EFA78845.1 - 6.2 6.9 6.6 6 6.9 0.2 3.0 3 0 0 3 3 3 0 Apolipoprotein B100 C terminal PCI PF01399.27 EFA78846.1 - 1.8e-08 34.8 0.7 3e-08 34.1 0.7 1.4 1 0 0 1 1 1 1 PCI domain Erf4 PF10256.9 EFA78847.1 - 0.0089 16.1 0.3 0.012 15.7 0.3 1.4 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Yippee-Mis18 PF03226.14 EFA78848.1 - 4.4e-19 68.6 3.5 1.2e-18 67.3 3.5 1.8 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TFIIA PF03153.13 EFA78848.1 - 1.8 8.5 31.0 5.3 6.9 10.3 2.2 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit H_lectin PF09458.10 EFA78849.1 - 1.6e-17 63.4 0.2 2.2e-17 63.0 0.2 1.2 1 0 0 1 1 1 1 H-type lectin domain EF-hand_4 PF12763.7 EFA78850.1 - 8.9e-20 70.6 0.0 8.9e-20 70.6 0.0 2.8 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EFA78850.1 - 0.00033 20.0 0.1 0.0007 19.0 0.1 1.6 1 0 0 1 1 1 1 EF hand TagA PF12561.8 EFA78850.1 - 0.00097 19.5 2.6 0.45 10.9 0.0 3.9 1 1 1 2 2 2 1 ToxR activated gene A lipoprotein domain EF-hand_6 PF13405.6 EFA78850.1 - 0.0083 16.0 0.0 0.024 14.6 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EFA78850.1 - 0.02 15.3 0.0 0.044 14.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 EFA78850.1 - 0.026 14.0 0.1 0.073 12.6 0.1 1.7 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 EFA78850.1 - 0.18 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair GAGA_bind PF06217.12 EFA78850.1 - 0.65 10.2 18.9 0.11 12.7 14.1 1.9 2 0 0 2 2 2 0 GAGA binding protein-like family AAA_23 PF13476.6 EFA78850.1 - 9.8 6.6 34.2 5.3 7.5 28.3 2.6 2 0 0 2 2 2 0 AAA domain TM2 PF05154.16 EFA78851.1 - 2.8e-11 43.5 5.8 2.8e-11 43.5 5.8 2.6 2 0 0 2 2 2 1 TM2 domain PKD PF00801.20 EFA78851.1 - 2.7e-05 23.9 3.0 0.00012 21.8 3.0 2.1 1 0 0 1 1 1 1 PKD domain DUF21 PF01595.20 EFA78851.1 - 0.05 13.3 0.1 0.099 12.3 0.1 1.4 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain CBFD_NFYB_HMF PF00808.23 EFA78852.1 - 5.1e-07 29.9 0.6 0.0005 20.3 0.0 2.4 1 1 1 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone p25-alpha PF05517.12 EFA78852.1 - 0.072 13.3 1.0 0.11 12.7 0.9 1.3 1 1 0 1 1 1 0 p25-alpha DUF1330 PF07045.11 EFA78852.1 - 0.095 13.1 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) ribosomal_L24 PF17136.4 EFA78853.1 - 5.2e-16 58.8 0.3 1e-15 57.9 0.3 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 EFA78853.1 - 2.1e-08 33.8 2.5 4.2e-08 32.9 0.9 2.3 3 0 0 3 3 3 1 KOW motif Ribosomal_L28e PF01778.17 EFA78854.1 - 1.7e-33 115.8 0.4 1.7e-33 115.8 0.4 2.3 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.14 EFA78854.1 - 7.1e-19 68.3 33.2 1.1e-18 67.7 29.5 2.7 2 1 0 2 2 2 1 Mak16 protein C-terminal region RNA_pol_3_Rpc31 PF11705.8 EFA78854.1 - 0.0042 17.4 17.4 0.0074 16.6 17.4 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EFA78854.1 - 0.014 14.7 10.5 0.021 14.2 10.5 1.2 1 0 0 1 1 1 0 BUD22 DUF2457 PF10446.9 EFA78854.1 - 0.082 12.0 18.8 0.12 11.5 18.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 EFA78854.1 - 0.26 9.5 18.4 0.38 8.9 18.4 1.2 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EFA78854.1 - 0.38 9.2 14.2 0.55 8.7 14.2 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop25 PF09805.9 EFA78854.1 - 1.6 9.2 19.4 7 7.1 19.4 2.0 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) FRQ PF09421.10 EFA78854.1 - 2.1 6.3 7.5 2.6 5.9 7.5 1.1 1 0 0 1 1 1 0 Frequency clock protein DUF4820 PF16091.5 EFA78854.1 - 2.5 7.4 6.8 1.3 8.3 4.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Lipoprotein_17 PF04200.12 EFA78855.1 - 0.086 13.2 3.1 0.14 12.6 0.3 2.0 1 1 1 2 2 2 0 Lipoprotein associated domain Methyltransf_7 PF03492.15 EFA78856.1 - 3.3e-41 141.6 1.0 5.3e-41 140.9 1.0 1.3 1 1 0 1 1 1 1 SAM dependent carboxyl methyltransferase IGR PF09597.10 EFA78857.1 - 3.6e-23 81.4 0.1 5.9e-23 80.7 0.1 1.3 1 0 0 1 1 1 1 IGR protein motif Ank_5 PF13857.6 EFA78858.1 - 6e-16 58.3 0.5 2.4e-09 37.3 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA78858.1 - 1e-15 57.9 0.2 7.8e-14 51.9 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA78858.1 - 3e-14 53.4 0.0 6.7e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFA78858.1 - 6.8e-13 48.4 0.0 1.3e-05 25.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EFA78858.1 - 2.2e-12 46.0 0.0 2.8e-05 24.2 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Chordopox_A13L PF05961.11 EFA78860.1 - 0.075 13.3 0.1 0.31 11.3 0.1 2.1 1 0 0 1 1 1 0 Chordopoxvirus A13L protein ATP-synt_8 PF00895.20 EFA78860.1 - 9.5 6.8 8.6 0.21 12.1 0.7 2.5 3 0 0 3 3 3 0 ATP synthase protein 8 GATA PF00320.27 EFA78861.1 - 5.1e-13 48.4 3.4 1.5e-12 46.9 3.4 1.9 1 0 0 1 1 1 1 GATA zinc finger Mucin PF01456.17 EFA78861.1 - 1 9.4 21.7 1.5 8.8 21.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Cytochrom_c3_2 PF14537.6 EFA78861.1 - 2.4 8.7 9.3 1.3 9.6 6.0 2.2 2 1 0 2 2 2 0 Cytochrome c3 FAM76 PF16046.5 EFA78861.1 - 2.7 7.3 20.7 0.22 10.8 12.7 2.0 2 0 0 2 2 2 0 FAM76 protein Dicty_REP PF05086.12 EFA78861.1 - 2.8 5.8 14.3 3.7 5.4 14.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-H2C2_2 PF13465.6 EFA78861.1 - 4.5 7.9 8.7 0.18 12.3 1.5 2.4 3 0 0 3 3 3 0 Zinc-finger double domain DUF2072 PF09845.9 EFA78861.1 - 7.7 6.8 13.6 1.8 8.8 9.5 1.9 2 0 0 2 2 2 0 Zn-ribbon containing protein CPSase_L_D2 PF02786.17 EFA78863.1 - 7.7e-77 257.5 0.0 1.4e-76 256.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFA78863.1 - 1.2e-46 157.8 0.1 3.6e-46 156.2 0.1 1.9 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFA78863.1 - 5.3e-37 126.2 0.0 1.7e-36 124.6 0.0 1.8 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFA78863.1 - 8.7e-17 60.7 2.4 3.2e-16 58.9 1.7 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp PF02222.22 EFA78863.1 - 2.2e-12 46.9 0.0 6.4e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFA78863.1 - 3.2e-12 46.4 0.0 6.8e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFA78863.1 - 9.3e-06 25.8 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EFA78863.1 - 1.6e-05 24.6 1.8 0.002 17.9 0.1 2.9 2 1 1 3 3 3 1 Biotin-lipoyl like RnfC_N PF13375.6 EFA78863.1 - 0.00017 21.5 0.1 0.0006 19.7 0.1 2.0 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 EFA78863.1 - 0.00038 21.1 0.2 0.14 12.9 0.1 3.4 3 0 0 3 3 3 1 HlyD family secretion protein GARS_A PF01071.19 EFA78863.1 - 0.00064 19.5 0.0 0.0019 18.0 0.0 1.9 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 EFA78863.1 - 0.0056 16.3 0.0 0.026 14.1 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 EFA78863.1 - 0.017 14.4 0.0 0.2 10.9 0.0 2.2 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 EFA78863.1 - 0.031 13.9 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain HlyD_D23 PF16576.5 EFA78863.1 - 0.063 12.5 0.1 2.6 7.2 0.0 2.4 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 EFA78863.1 - 0.093 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein Pyr_redox_2 PF07992.14 EFA78864.1 - 1.9e-31 109.4 0.2 1.6e-19 70.2 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA78864.1 - 1.9e-05 25.2 0.1 0.027 15.0 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 EFA78864.1 - 0.00047 20.0 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain NAD_binding_9 PF13454.6 EFA78864.1 - 0.019 14.9 0.0 6.8 6.7 0.0 3.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFA78864.1 - 0.067 12.4 4.6 3.2 6.9 1.0 2.7 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA78864.1 - 0.068 12.7 0.1 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA78864.1 - 0.1 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFA78864.1 - 0.11 11.5 0.0 0.51 9.4 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Mqo PF06039.15 EFA78864.1 - 0.13 10.8 0.1 5.9 5.3 0.0 2.3 2 1 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.12 EFA78864.1 - 0.21 10.6 0.0 1.6 7.7 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein ALMS_motif PF15309.6 EFA78867.1 - 0.0058 17.1 0.5 4.9 7.6 0.1 3.0 3 0 0 3 3 3 1 ALMS motif Ead_Ea22 PF13935.6 EFA78867.1 - 0.01 16.5 0.6 5.1 7.7 0.0 2.6 2 0 0 2 2 2 0 Ead/Ea22-like protein T6SS_HCP PF05638.12 EFA78867.1 - 0.026 14.9 7.5 19 5.7 0.1 5.2 3 2 2 5 5 5 0 Type VI secretion system effector, Hcp alpha-hel2 PF14456.6 EFA78867.1 - 0.045 13.1 2.1 4.6 6.4 0.1 2.6 2 0 0 2 2 2 0 Alpha-helical domain 2 Ras PF00071.22 EFA78867.1 - 0.056 13.1 1.9 4.1 7.0 0.2 2.5 2 0 0 2 2 2 0 Ras family ER PF01133.17 EFA78867.1 - 0.062 13.3 6.2 4.5 7.4 0.4 3.3 2 0 0 2 2 2 0 Enhancer of rudimentary PsbU PF06514.11 EFA78867.1 - 0.073 13.1 0.1 22 5.1 0.0 3.2 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) CAMSAP_CH PF11971.8 EFA78867.1 - 0.23 11.3 5.5 63 3.5 0.1 4.4 4 0 0 4 4 4 0 CAMSAP CH domain SwrA PF17423.2 EFA78867.1 - 0.92 9.5 6.7 25 4.9 0.1 4.3 4 1 0 4 4 4 0 Swarming motility protein DUF1655 PF07868.11 EFA78867.1 - 1.4 9.1 3.8 35 4.5 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1655) Mak16 PF04874.14 EFA78867.1 - 6 7.5 12.6 13 6.5 1.3 2.8 2 0 0 2 2 2 0 Mak16 protein C-terminal region SDA1 PF05285.12 EFA78867.1 - 6.2 6.1 10.8 6.2 6.2 1.2 2.2 2 0 0 2 2 2 0 SDA1 CENP-B_dimeris PF09026.10 EFA78867.1 - 6.4 7.2 23.8 6.5 7.2 1.9 3.5 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Kelch_6 PF13964.6 EFA78868.1 - 4.6e-18 64.8 3.8 8.3e-09 35.4 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFA78868.1 - 0.0017 18.3 0.2 4.2 7.5 0.0 4.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA78868.1 - 0.16 11.6 3.6 1.8 8.2 0.0 4.0 5 0 0 5 5 5 0 Kelch motif zf-HIT PF04438.16 EFA78868.1 - 0.24 11.3 5.0 0.54 10.2 5.0 1.6 1 0 0 1 1 1 0 HIT zinc finger zf-B_box PF00643.24 EFA78868.1 - 0.41 10.8 18.5 1.1 9.5 18.5 1.6 1 0 0 1 1 1 0 B-box zinc finger Folate_carrier PF01770.18 EFA78868.1 - 3.3 6.3 5.7 8.2 5.0 5.7 1.6 1 0 0 1 1 1 0 Reduced folate carrier DUF1736 PF08409.11 EFA78869.1 - 2.6e-18 65.8 2.0 5.6e-17 61.5 0.7 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1736) TPR_2 PF07719.17 EFA78869.1 - 0.015 15.3 0.3 2.4 8.5 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA78869.1 - 0.024 14.9 0.6 3.5 8.0 0.2 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78869.1 - 0.055 13.7 1.9 2.5 8.6 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat CDC45 PF02724.14 EFA78869.1 - 0.075 11.3 9.5 0.14 10.5 9.5 1.3 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 EFA78869.1 - 0.075 11.9 7.3 0.15 10.9 7.3 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) TPR_1 PF00515.28 EFA78869.1 - 0.11 12.4 1.7 1.2 9.1 0.3 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Profilin PF00235.19 EFA78870.1 - 6.9e-25 87.8 0.1 5.2e-21 75.2 0.0 2.0 1 1 1 2 2 2 2 Profilin DSHCT PF08148.12 EFA78871.1 - 0.06 13.0 0.0 0.17 11.5 0.0 1.7 1 1 0 1 1 1 0 DSHCT (NUC185) domain Resolvase PF00239.21 EFA78872.1 - 9.2e-05 22.6 2.1 0.00026 21.1 0.0 2.2 2 1 0 2 2 2 1 Resolvase, N terminal domain DUF3439 PF11921.8 EFA78873.1 - 0.15 12.0 1.6 0.4 10.6 1.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3439) Dmrt1 PF12374.8 EFA78873.1 - 1 9.8 6.7 6.4 7.3 0.1 4.1 2 1 2 4 4 4 0 Double-sex mab3 related transcription factor 1 Secretin_N_2 PF07655.13 EFA78873.1 - 1.7 9.2 18.1 0.079 13.5 8.3 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Profilin PF00235.19 EFA78874.1 - 1.1e-18 67.7 0.3 1.4e-18 67.4 0.3 1.1 1 0 0 1 1 1 1 Profilin EGF_2 PF07974.13 EFA78876.1 - 2.5e-06 27.7 9.7 6.1e-06 26.5 9.7 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA78876.1 - 0.0093 16.0 5.1 0.02 14.9 5.1 1.5 1 0 0 1 1 1 1 Tenascin EGF domain VSP PF03302.13 EFA78876.1 - 0.076 11.9 0.1 0.076 11.9 0.1 2.2 2 0 0 2 2 2 0 Giardia variant-specific surface protein hEGF PF12661.7 EFA78876.1 - 1.3 9.7 7.3 4.2 8.1 7.3 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF Toxin_2 PF00451.19 EFA78876.1 - 3 8.2 4.9 9.8 6.6 4.9 1.9 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 zf-B_box PF00643.24 EFA78878.1 - 9.4e-07 28.9 8.5 1.8e-06 27.9 8.5 1.4 1 0 0 1 1 1 1 B-box zinc finger DUF1043 PF06295.12 EFA78878.1 - 0.039 13.9 1.0 0.039 13.9 1.0 3.7 2 1 1 4 4 4 0 Protein of unknown function (DUF1043) Glyco_hydro_18 PF00704.28 EFA78880.1 - 2.7e-13 50.3 0.7 6.9e-13 49.0 0.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 zf-B_box PF00643.24 EFA78883.1 - 2e-05 24.6 10.3 4.5e-05 23.5 10.3 1.6 1 0 0 1 1 1 1 B-box zinc finger TolA_bind_tri PF16331.5 EFA78883.1 - 0.3 11.2 7.5 27 4.9 0.0 3.9 4 0 0 4 4 4 0 TolA binding protein trimerisation IBR PF01485.21 EFA78883.1 - 1.6 9.0 4.4 4.2 7.7 4.4 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Prefoldin_2 PF01920.20 EFA78885.1 - 0.063 13.2 3.3 5.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit CBM64 PF18666.1 EFA78885.1 - 0.1 12.7 0.3 0.1 12.7 0.3 2.0 2 0 0 2 2 2 0 Carbohydrate-binding module 64 DUF1664 PF07889.12 EFA78885.1 - 0.35 10.9 3.0 0.6 10.2 2.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EFA78885.1 - 1.3 9.2 6.0 2.9 8.1 6.0 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Ras PF00071.22 EFA78886.1 - 3.7e-24 85.1 0.0 7.1e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA78886.1 - 1.4e-08 34.9 0.0 3.5e-08 33.7 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78886.1 - 0.00079 18.9 0.1 0.002 17.6 0.1 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF1533 PF07550.11 EFA78886.1 - 0.024 14.5 0.8 0.59 10.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) Glyco_hydro_18 PF00704.28 EFA78887.1 - 8.2e-09 35.6 2.3 1.1e-08 35.2 0.5 1.7 1 1 1 2 2 2 1 Glycosyl hydrolases family 18 zf-B_box PF00643.24 EFA78890.1 - 8.5e-05 22.6 7.6 8.5e-05 22.6 7.6 2.0 2 0 0 2 2 2 1 B-box zinc finger Serine_rich PF08824.10 EFA78890.1 - 0.052 13.5 3.1 0.13 12.3 3.0 1.8 1 1 0 1 1 1 0 Serine rich protein interaction domain Lipl32 PF12103.8 EFA78890.1 - 0.77 9.4 8.1 1.7 8.3 0.7 2.3 2 0 0 2 2 2 0 Surface lipoprotein of Spirochaetales order Cep57_CLD PF14073.6 EFA78890.1 - 0.95 9.5 6.2 5 7.1 0.4 3.0 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 GLE1 PF07817.13 EFA78890.1 - 2.3 7.3 5.1 6.4 5.9 5.0 2.0 1 1 0 1 1 1 0 GLE1-like protein zf-B_box PF00643.24 EFA78892.1 - 9e-07 29.0 7.5 1.7e-06 28.1 7.5 1.5 1 0 0 1 1 1 1 B-box zinc finger Laminin_I PF06008.14 EFA78892.1 - 0.0031 17.3 3.3 0.0057 16.4 3.2 1.4 1 1 0 1 1 1 1 Laminin Domain I Syntaxin-6_N PF09177.11 EFA78892.1 - 0.18 12.4 6.6 2.9 8.5 0.7 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Ras PF00071.22 EFA78893.1 - 4.3e-36 123.9 0.0 8e-36 123.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA78893.1 - 4.5e-16 59.1 0.0 4.5e-16 59.1 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA78893.1 - 5e-09 35.8 0.0 9.2e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family zf-B_box PF00643.24 EFA78894.1 - 1e-06 28.8 11.3 1.2e-06 28.5 8.8 2.2 2 0 0 2 2 2 1 B-box zinc finger MAP65_ASE1 PF03999.12 EFA78894.1 - 0.00018 20.4 8.4 0.00022 20.1 8.4 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) IBR PF01485.21 EFA78894.1 - 0.32 11.2 4.4 0.89 9.8 4.4 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain FlgN PF05130.12 EFA78894.1 - 4.6 7.7 12.6 9.5 6.7 12.0 1.8 1 1 0 1 1 1 0 FlgN protein zf-B_box PF00643.24 EFA78895.1 - 7.9e-06 25.9 10.8 2e-05 24.6 10.8 1.7 1 0 0 1 1 1 1 B-box zinc finger DUF1664 PF07889.12 EFA78895.1 - 0.35 10.9 5.7 0.05 13.7 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 EFA78895.1 - 0.37 10.3 3.9 2.3 7.8 0.8 2.5 2 0 0 2 2 2 0 fzo-like conserved region IBR PF01485.21 EFA78895.1 - 0.54 10.5 5.2 1.5 9.1 5.2 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Snapin_Pallidin PF14712.6 EFA78895.1 - 0.59 10.6 8.0 0.25 11.8 4.2 2.3 2 0 0 2 2 2 0 Snapin/Pallidin PCRF PF03462.18 EFA78895.1 - 1.8 8.4 13.7 0.8 9.5 0.2 2.8 1 1 1 3 3 3 0 PCRF domain Ank_4 PF13637.6 EFA78896.1 - 3.6e-34 116.7 17.4 0.00026 21.5 0.1 10.9 6 2 7 13 13 13 10 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA78896.1 - 7.9e-34 116.1 25.5 4.1e-08 33.7 0.5 6.7 2 1 7 9 9 9 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA78896.1 - 3.3e-22 78.3 22.3 0.0033 17.7 0.1 12.2 3 1 10 14 14 14 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78896.1 - 1.1e-21 74.6 8.8 0.34 11.6 0.1 13.7 11 2 4 15 15 14 4 Ankyrin repeat DUF4411 PF14367.6 EFA78896.1 - 0.00057 19.8 3.7 1 9.3 0.1 3.7 1 1 0 3 3 3 2 Domain of unknown function (DUF4411) Ank PF00023.30 EFA78896.1 - 0.0053 17.2 6.6 5.3 7.7 1.0 6.6 7 1 2 9 9 7 1 Ankyrin repeat AbiEi_3_N PF17194.4 EFA78896.1 - 0.0065 16.5 0.2 1.5 8.9 0.0 3.8 2 2 1 4 4 4 1 Transcriptional regulator, AbiEi antitoxin N-terminal domain DUF3447 PF11929.8 EFA78896.1 - 0.0081 16.1 7.3 0.96 9.4 0.1 5.0 4 3 1 5 5 5 1 Domain of unknown function (DUF3447) DUF1843 PF08898.10 EFA78896.1 - 0.023 15.2 0.1 59 4.3 0.0 5.0 7 0 0 7 7 6 0 Domain of unknown function (DUF1843) DUF3322 PF11795.8 EFA78896.1 - 0.097 12.7 0.5 68 3.4 0.0 4.3 1 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) NODP PF07684.12 EFA78896.1 - 0.31 11.2 0.8 72 3.7 0.0 3.6 3 1 0 3 3 3 0 NOTCH protein YkuD PF03734.14 EFA78896.1 - 8.5 6.8 5.6 21 5.5 1.0 3.3 1 1 1 2 2 2 0 L,D-transpeptidase catalytic domain H_lectin PF09458.10 EFA78897.1 - 4.2e-18 65.3 0.3 6e-18 64.8 0.3 1.2 1 0 0 1 1 1 1 H-type lectin domain TPR_12 PF13424.6 EFA78898.1 - 2.4e-08 34.1 0.9 0.00025 21.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA78898.1 - 0.0002 21.0 13.1 0.031 14.1 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-MYND PF01753.18 EFA78898.1 - 0.00021 21.3 14.3 0.00057 19.9 14.3 1.8 1 0 0 1 1 1 1 MYND finger DUF5348 PF17295.2 EFA78898.1 - 0.03 14.2 0.1 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) TPR_2 PF07719.17 EFA78898.1 - 0.039 14.1 12.3 0.52 10.6 1.4 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA78898.1 - 0.36 11.8 1.5 1.6 9.7 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78898.1 - 5.4 7.5 13.3 0.34 11.2 0.6 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-B_box PF00643.24 EFA78899.1 - 2.3e-05 24.4 9.5 4.5e-05 23.5 9.5 1.4 1 0 0 1 1 1 1 B-box zinc finger Methyltransf_14 PF08484.11 EFA78899.1 - 0.052 13.3 1.2 8.8 6.1 0.0 2.8 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain FlgN PF05130.12 EFA78899.1 - 6.1 7.3 15.0 0.083 13.4 4.4 2.8 3 0 0 3 3 3 0 FlgN protein TPR_12 PF13424.6 EFA78900.1 - 0.00017 21.8 4.2 0.33 11.3 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-MYND PF01753.18 EFA78900.1 - 0.00018 21.5 15.1 0.00062 19.8 15.1 2.0 1 0 0 1 1 1 1 MYND finger Sel1 PF08238.12 EFA78900.1 - 0.0018 18.9 0.0 19 6.1 0.0 4.3 5 0 0 5 5 5 0 Sel1 repeat TPR_16 PF13432.6 EFA78900.1 - 0.0085 16.7 0.7 9.6 7.0 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA78900.1 - 0.0093 15.8 0.5 0.0093 15.8 0.5 4.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA78900.1 - 0.034 14.8 3.4 1 10.1 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA78900.1 - 0.038 14.2 0.2 0.038 14.2 0.2 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA78900.1 - 0.05 13.7 0.2 0.05 13.7 0.2 5.1 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA78900.1 - 0.093 13.2 1.1 16 6.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat BCMA-Tall_bind PF09257.10 EFA78900.1 - 2.5 8.3 13.3 9.1 6.5 13.3 1.9 1 0 0 1 1 1 0 BCMA, TALL-1 binding H_lectin PF09458.10 EFA78901.1 - 3.1e-18 65.7 0.4 4.3e-18 65.2 0.4 1.2 1 0 0 1 1 1 1 H-type lectin domain zf-B_box PF00643.24 EFA78902.1 - 6.1e-07 29.5 8.7 1.1e-06 28.6 8.7 1.4 1 0 0 1 1 1 1 B-box zinc finger DUF1664 PF07889.12 EFA78902.1 - 1.8 8.6 8.5 0.19 11.8 1.8 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) IBR PF01485.21 EFA78902.1 - 1.9 8.8 5.4 4.6 7.5 5.4 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain PB1 PF00564.24 EFA78903.1 - 0.082 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 PB1 domain SWI-SNF_Ssr4 PF08549.10 EFA78903.1 - 3.7 6.1 10.6 4.8 5.7 10.6 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Pap_E4 PF02711.14 EFA78903.1 - 4 8.5 7.9 7.4 7.6 0.1 2.9 3 0 0 3 3 3 0 E4 protein GSAP-16 PF14959.6 EFA78904.1 - 3.2e-16 59.1 0.2 9.5e-16 57.6 0.2 1.8 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term MID_MedPIWI PF18296.1 EFA78904.1 - 0.068 12.9 0.9 2.4 7.9 0.1 2.4 2 0 0 2 2 2 0 MID domain of medPIWI PTP_tm PF18861.1 EFA78904.1 - 0.14 12.1 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Hom_end_hint PF05203.16 EFA78905.1 - 0.0078 16.2 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Hom_end-associated Hint ArfGap PF01412.18 EFA78906.1 - 6.5e-43 145.5 0.1 6.5e-43 145.5 0.1 3.2 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf LTV PF04180.14 EFA78907.1 - 3.3e-06 27.1 62.6 0.0024 17.7 12.0 4.7 1 1 2 3 3 3 2 Low temperature viability protein PhoPQ_related PF10142.9 EFA78908.1 - 4.8e-187 621.0 7.5 5.1e-95 318.2 1.0 2.3 2 0 0 2 2 2 2 PhoPQ-activated pathogenicity-related protein Kelch_6 PF13964.6 EFA78908.1 - 2.8e-17 62.3 3.3 1.5e-09 37.8 0.1 6.4 4 1 1 5 5 5 3 Kelch motif Dicty_CTDC PF00526.18 EFA78908.1 - 0.00012 21.9 7.5 0.00012 21.9 7.5 5.3 4 1 0 4 4 4 1 Dictyostelium (slime mold) repeat FERM_C PF09380.10 EFA78908.1 - 0.0053 17.1 0.1 1.5 9.2 0.0 3.1 3 0 0 3 3 3 1 FERM C-terminal PH-like domain Kelch_4 PF13418.6 EFA78908.1 - 0.0063 16.5 2.3 3.1 7.9 0.0 4.8 5 0 0 5 5 5 1 Galactose oxidase, central domain T3SS_ATPase_C PF18269.1 EFA78908.1 - 0.03 14.2 0.0 9.2 6.2 0.0 2.5 2 0 0 2 2 2 0 T3SS EscN ATPase C-terminal domain Kelch_1 PF01344.25 EFA78908.1 - 0.074 12.7 3.5 0.21 11.2 0.0 3.7 4 0 0 4 4 4 0 Kelch motif LRR_8 PF13855.6 EFA78909.1 - 2.9e-14 52.6 12.7 2.5e-07 30.4 2.4 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFA78909.1 - 5.8e-11 42.5 15.5 7.1e-07 29.5 5.1 3.3 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA78909.1 - 0.0023 18.2 12.4 0.17 12.5 0.3 4.8 4 1 1 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 EFA78909.1 - 0.0061 16.1 0.5 0.0085 15.6 0.5 1.3 1 0 0 1 1 1 1 Leucine-rich repeat T6SS_VipA PF05591.12 EFA78909.1 - 0.011 15.6 0.1 0.025 14.4 0.1 1.6 1 1 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 LRR_6 PF13516.6 EFA78909.1 - 0.46 10.7 21.0 0.82 9.9 0.3 4.6 5 0 0 5 5 5 0 Leucine Rich repeat LRR_3 PF07725.12 EFA78909.1 - 8.7 6.4 7.7 16 5.5 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat bZIP_2 PF07716.15 EFA78910.1 - 3.5e-05 23.8 12.7 3.5e-05 23.8 12.7 6.3 5 3 1 6 6 6 1 Basic region leucine zipper bZIP_1 PF00170.21 EFA78910.1 - 0.00013 22.0 13.3 0.00013 22.0 13.3 2.9 3 0 0 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.17 EFA78910.1 - 0.0056 17.2 3.1 0.0056 17.2 3.1 9.0 5 3 3 8 8 8 1 bZIP Maf transcription factor DUF1192 PF06698.11 EFA78910.1 - 0.052 13.6 2.9 0.22 11.6 2.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Urocanase PF01175.18 EFA78911.1 - 7.4e-90 300.2 0.0 1.1e-89 299.7 0.0 1.3 1 0 0 1 1 1 1 Urocanase Rossmann-like domain Urocanase_C PF17392.2 EFA78911.1 - 3.8e-86 287.5 2.2 7e-86 286.7 2.2 1.4 1 0 0 1 1 1 1 Urocanase C-terminal domain Urocanase_N PF17391.2 EFA78911.1 - 1.3e-57 192.9 0.2 3.1e-57 191.8 0.2 1.7 1 0 0 1 1 1 1 Urocanase N-terminal domain TIP49 PF06068.13 EFA78912.1 - 8.1e-169 561.4 0.3 1e-168 561.0 0.3 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFA78912.1 - 5.1e-23 81.0 0.1 3.1e-22 78.5 0.1 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EFA78912.1 - 2.5e-11 44.1 0.3 3.2e-07 30.8 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFA78912.1 - 4.5e-10 39.5 0.2 2.3e-06 27.5 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFA78912.1 - 2.8e-06 27.6 0.2 0.026 14.8 0.0 2.9 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 EFA78912.1 - 0.00012 22.1 0.1 0.023 14.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFA78912.1 - 0.0002 20.8 0.3 0.013 14.9 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EFA78912.1 - 0.00064 19.4 0.0 0.0056 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA78912.1 - 0.00074 19.9 0.0 0.014 15.8 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 EFA78912.1 - 0.0029 17.0 0.0 0.0087 15.4 0.0 1.8 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_14 PF13173.6 EFA78912.1 - 0.0044 17.1 0.0 1.9 8.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EFA78912.1 - 0.0059 16.4 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 EFA78912.1 - 0.0063 16.2 0.1 1.8 8.2 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 EFA78912.1 - 0.0087 16.4 3.2 0.38 11.1 3.2 2.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFA78912.1 - 0.017 15.4 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFA78912.1 - 0.02 15.1 0.0 0.058 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFA78912.1 - 0.025 13.8 0.2 0.062 12.6 0.2 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 EFA78912.1 - 0.046 13.5 1.5 0.055 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFA78912.1 - 0.051 13.1 0.1 0.22 11.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 EFA78912.1 - 0.053 13.0 0.1 0.053 13.0 0.1 2.3 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 EFA78912.1 - 0.061 13.3 0.2 2.1 8.3 0.1 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit TsaE PF02367.17 EFA78912.1 - 0.077 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFA78912.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EFA78912.1 - 0.086 13.2 0.0 0.32 11.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EFA78912.1 - 0.11 13.1 0.0 0.29 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Ribophorin_I PF04597.14 EFA78913.1 - 7.8e-120 401.0 4.0 1.4e-119 400.2 4.0 1.4 1 0 0 1 1 1 1 Ribophorin I UPF0231 PF06062.11 EFA78913.1 - 0.00027 21.2 2.9 0.00073 19.8 0.4 2.4 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0231) FAM76 PF16046.5 EFA78913.1 - 0.24 10.7 1.9 0.51 9.7 1.9 1.5 1 0 0 1 1 1 0 FAM76 protein DNA_repr_REX1B PF14966.6 EFA78913.1 - 1.3 9.8 5.1 5.6 7.7 5.1 2.2 1 1 0 1 1 1 0 DNA repair REX1-B Rad51 PF08423.11 EFA78915.1 - 9.1e-129 428.2 0.0 1.1e-128 427.9 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EFA78915.1 - 5.9e-11 42.3 0.0 1.1e-10 41.4 0.0 1.4 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EFA78915.1 - 3.2e-10 39.9 0.0 4.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EFA78915.1 - 2.3e-06 28.1 0.6 6.3e-06 26.7 0.6 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 EFA78915.1 - 3.5e-05 23.2 1.1 0.00017 21.1 1.2 2.1 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EFA78915.1 - 0.0097 15.3 0.2 0.25 10.6 0.1 2.3 1 1 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 EFA78915.1 - 0.08 12.7 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 EFA78915.1 - 0.089 12.8 0.4 0.2 11.7 0.4 1.6 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain AAA_28 PF13521.6 EFA78915.1 - 0.19 12.0 0.1 0.19 12.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain Sortilin-Vps10 PF15902.5 EFA78916.1 - 5.3e-66 223.3 15.4 6.7e-66 222.9 15.4 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EFA78916.1 - 1.2e-26 94.1 0.0 1.9e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EFA78916.1 - 0.0048 16.7 39.9 0.95 9.7 2.3 8.6 8 0 0 8 8 8 5 BNR/Asp-box repeat BNR_6 PF15899.5 EFA78916.1 - 0.0072 16.3 12.1 4.6 7.6 0.0 6.2 6 0 0 6 6 6 2 BNR-Asp box repeat Glyco_hydro_65C PF03633.15 EFA78917.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain Pept_tRNA_hydro PF01195.19 EFA78918.1 - 3e-49 167.3 0.2 7.5e-49 166.0 0.2 1.6 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase DDHD PF02862.17 EFA78918.1 - 0.045 13.9 2.8 0.16 12.1 2.8 1.9 1 1 0 1 1 1 0 DDHD domain Myc_N PF01056.18 EFA78918.1 - 0.49 10.2 9.4 0.11 12.3 4.7 2.0 2 0 0 2 2 2 0 Myc amino-terminal region YjbH PF06082.11 EFA78918.1 - 0.72 8.6 5.2 0.9 8.3 5.2 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DUF702 PF05142.12 EFA78918.1 - 1.5 9.3 5.9 0.28 11.6 1.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF702) SSP160 PF06933.11 EFA78918.1 - 2.4 6.2 8.8 3.9 5.6 8.8 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF383 PF04063.14 EFA78919.1 - 1.7e-36 125.7 0.4 1.7e-36 125.7 0.4 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EFA78919.1 - 9.9e-20 70.1 1.0 2.6e-19 68.8 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF384) HEAT_2 PF13646.6 EFA78919.1 - 0.0016 18.8 0.0 0.8 10.1 0.0 3.3 3 0 0 3 3 3 1 HEAT repeats Cnd1 PF12717.7 EFA78919.1 - 0.0024 17.9 3.6 0.0031 17.6 0.3 2.6 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EFA78919.1 - 0.0035 17.3 0.7 4.3 7.5 0.0 4.0 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 EFA78919.1 - 0.0045 17.4 0.1 0.018 15.5 0.1 2.0 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain 2-Hacid_dh_C PF02826.19 EFA78920.1 - 4.8e-54 182.4 0.1 8.5e-54 181.6 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFA78920.1 - 1e-30 106.1 0.0 1.2e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 EFA78920.1 - 3.8e-06 26.6 0.1 8.9e-06 25.4 0.1 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 EFA78920.1 - 9.5e-05 22.6 0.2 0.00034 20.8 0.2 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EFA78920.1 - 0.00011 22.3 1.0 0.00017 21.7 1.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 EFA78920.1 - 0.011 15.6 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EFA78920.1 - 0.035 14.1 0.1 0.17 11.9 0.0 2.1 2 0 0 2 2 2 0 Zinc-binding dehydrogenase F420_oxidored PF03807.17 EFA78920.1 - 0.036 14.6 0.0 0.082 13.5 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_C PF03720.15 EFA78920.1 - 0.084 13.3 0.1 0.45 11.0 0.0 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Img2 PF05046.14 EFA78921.1 - 6.7e-18 64.8 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DUF900 PF05990.12 EFA78923.1 - 7.9e-18 64.8 0.2 1.1e-17 64.3 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 EFA78923.1 - 0.066 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA78923.1 - 0.15 12.6 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family TPR_17 PF13431.6 EFA78924.1 - 1.5e-17 62.7 0.2 3e-07 30.3 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA78924.1 - 0.035 13.8 2.4 0.16 11.7 0.1 2.5 3 0 0 3 3 3 0 TPR repeat DUF599 PF04654.12 EFA78928.1 - 5.7e-54 182.7 13.6 6.9e-54 182.5 13.6 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF599 Arf PF00025.21 EFA78929.1 - 1e-48 165.1 0.1 1.5e-48 164.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFA78929.1 - 2.2e-14 53.4 3.4 1.1e-10 41.3 0.3 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFA78929.1 - 1.1e-09 38.6 0.0 2.2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFA78929.1 - 1.5e-08 34.3 0.0 2.9e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EFA78929.1 - 3.4e-08 33.2 0.0 5.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFA78929.1 - 3.7e-07 29.7 0.0 5.7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFA78929.1 - 2e-05 24.6 0.0 4.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA78929.1 - 0.00014 21.8 0.2 0.52 10.2 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFA78929.1 - 0.00032 20.3 0.4 0.018 14.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EFA78929.1 - 0.00054 20.2 0.9 0.023 15.0 0.9 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFA78929.1 - 0.00076 19.9 0.1 0.0024 18.3 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain cobW PF02492.19 EFA78929.1 - 0.0051 16.4 1.4 0.85 9.2 0.2 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EFA78929.1 - 0.0095 16.5 1.2 0.017 15.6 0.4 2.0 1 1 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EFA78929.1 - 0.014 15.9 1.1 0.014 15.9 1.1 1.9 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 EFA78929.1 - 0.016 15.7 0.0 0.032 14.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 EFA78929.1 - 0.035 13.8 0.1 0.09 12.5 0.1 1.7 1 0 0 1 1 1 0 Thymidylate kinase NACHT PF05729.12 EFA78929.1 - 0.041 13.8 0.1 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 EFA78929.1 - 0.057 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFA78929.1 - 0.075 12.8 0.0 4.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 EFA78929.1 - 0.083 12.8 1.6 0.16 11.9 0.3 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IES5 PF17335.2 EFA78929.1 - 0.12 12.6 3.3 0.31 11.3 0.1 2.8 3 1 1 4 4 3 0 Ino80 complex subunit 5 AAA_17 PF13207.6 EFA78929.1 - 0.15 12.5 0.0 0.38 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFA78929.1 - 0.16 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Acyl-CoA_dh_M PF02770.19 EFA78930.1 - 1.6e-12 47.5 0.0 2.7e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain ACOX PF01756.19 EFA78930.1 - 8.2e-10 38.5 0.0 1.6e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 EFA78930.1 - 5e-08 33.3 0.0 8.1e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DC_STAMP PF07782.13 EFA78930.1 - 0.078 12.8 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 DC-STAMP-like protein Rad60-SLD PF11976.8 EFA78932.1 - 3.5e-23 81.2 0.7 4.3e-23 80.9 0.7 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFA78932.1 - 2.3e-15 56.1 0.3 3.1e-15 55.7 0.2 1.3 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 EFA78932.1 - 0.017 15.5 0.5 0.02 15.2 0.5 1.1 1 0 0 1 1 1 0 Ubiquitin-like domain G-alpha PF00503.20 EFA78933.1 - 2.2e-108 362.6 7.7 2.6e-108 362.4 7.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA78933.1 - 1.8e-15 56.8 0.7 7.4e-12 45.1 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA78933.1 - 0.00097 18.6 1.1 0.34 10.2 0.3 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA78933.1 - 0.0032 17.7 0.5 3.1 8.0 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA78933.1 - 0.024 14.7 0.0 3.5 7.7 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Ras PF00071.22 EFA78933.1 - 0.026 14.1 0.2 0.54 9.8 0.1 2.6 2 1 0 2 2 2 0 Ras family AAA_29 PF13555.6 EFA78933.1 - 0.065 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cnn_1N PF07989.11 EFA78934.1 - 3.7e-05 23.8 4.2 3.7e-05 23.8 4.2 12.7 9 4 3 12 12 12 2 Centrosomin N-terminal motif 1 HALZ PF02183.18 EFA78934.1 - 3.7e-05 23.9 5.1 3.7e-05 23.9 5.1 11.7 9 3 3 12 12 12 1 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.12 EFA78934.1 - 0.00072 19.6 12.4 0.00072 19.6 12.4 9.5 5 4 3 8 8 8 1 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EFA78934.1 - 0.0014 18.7 20.4 0.0014 18.7 20.4 9.3 4 2 5 9 9 9 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 EFA78934.1 - 0.002 17.1 38.6 0.002 17.1 38.6 5.8 1 1 4 5 5 5 1 Protein of unknown function (DUF812) DUF2663 PF10864.8 EFA78934.1 - 0.62 10.5 9.1 3.7 8.0 3.7 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) DUF4407 PF14362.6 EFA78934.1 - 2.1 7.6 123.1 0.013 14.9 11.3 7.6 2 1 4 7 7 7 0 Domain of unknown function (DUF4407) Citrate_synt PF00285.21 EFA78935.1 - 8.9e-139 462.5 0.0 1.1e-138 462.3 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Pkinase_Tyr PF07714.17 EFA78936.1 - 8.1e-69 231.8 0.0 1.2e-68 231.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA78936.1 - 7.7e-60 202.5 0.0 2.3e-59 200.9 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Kelch_3 PF13415.6 EFA78936.1 - 1.1e-22 79.7 3.4 6e-07 29.6 0.1 6.3 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA78936.1 - 2.6e-19 68.8 10.0 0.0035 17.3 0.0 6.9 7 0 0 7 7 6 5 Kelch motif Kelch_2 PF07646.15 EFA78936.1 - 4.7e-19 67.6 4.8 6.7e-06 25.9 0.0 7.2 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EFA78936.1 - 5e-18 64.4 1.2 0.0006 19.3 0.0 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EFA78936.1 - 3.1e-17 62.3 9.5 1.2e-05 25.2 0.2 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA78936.1 - 2.5e-15 56.1 4.9 0.018 15.3 0.0 6.8 6 0 0 6 6 6 4 Kelch motif Kinase-like PF14531.6 EFA78936.1 - 0.0018 17.7 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFA78936.1 - 0.1 12.0 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cadherin_C_2 PF16492.5 EFA78936.1 - 0.39 11.5 0.0 0.39 11.5 0.0 3.4 3 1 1 4 4 4 0 Cadherin cytoplasmic C-terminal Sds3 PF08598.11 EFA78937.1 - 4.5e-11 43.2 12.2 4.5e-11 43.2 12.2 4.8 2 2 1 3 3 3 2 Sds3-like Glu-tRNAGln PF02686.15 EFA78938.1 - 5.5e-08 33.0 0.1 9.5e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit MucB_RseB PF03888.14 EFA78938.1 - 0.0094 15.5 0.4 0.017 14.6 0.4 1.5 1 0 0 1 1 1 1 MucB/RseB N-terminal domain DUF4422 PF14393.6 EFA78938.1 - 0.076 12.8 1.7 0.18 11.7 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4422) Homeodomain PF00046.29 EFA78939.1 - 4e-19 68.2 4.3 4e-19 68.2 4.3 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EFA78939.1 - 0.0041 17.0 0.3 0.0099 15.8 0.3 1.7 1 0 0 1 1 1 1 Homeobox KN domain RrnaAD PF00398.20 EFA78940.1 - 5.4e-63 212.5 0.1 6.6e-63 212.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFA78940.1 - 2.4e-08 34.5 0.0 4.6e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA78940.1 - 1e-05 26.1 0.0 1.9e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA78940.1 - 6.8e-05 23.5 0.0 0.00014 22.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFA78940.1 - 0.00029 20.5 0.0 0.0005 19.7 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 EFA78940.1 - 0.00038 19.8 0.0 0.00082 18.7 0.0 1.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EFA78940.1 - 0.00095 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EFA78940.1 - 0.0036 17.2 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 EFA78940.1 - 0.0056 15.8 0.0 0.0097 15.0 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_31 PF13847.6 EFA78940.1 - 0.0074 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA78940.1 - 0.0082 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Zn_ribbon_2 PF12674.7 EFA78940.1 - 0.011 16.4 0.2 0.024 15.3 0.2 1.6 1 0 0 1 1 1 0 Putative zinc ribbon domain Methyltransf_18 PF12847.7 EFA78940.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EFA78940.1 - 0.026 14.1 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PRMT5 PF05185.16 EFA78940.1 - 0.042 13.7 0.1 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase DOT1 PF08123.13 EFA78940.1 - 0.062 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_28 PF02636.17 EFA78940.1 - 0.063 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 EFA78940.1 - 0.083 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EFA78940.1 - 0.085 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase DUF3419 PF11899.8 EFA78940.1 - 0.11 11.7 0.1 1.6 7.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3419) Noelin-1 PF12308.8 EFA78941.1 - 0.23 11.4 5.3 0.17 11.9 2.5 2.0 2 0 0 2 2 2 0 Neurogenesis glycoprotein HAUS6_N PF14661.6 EFA78941.1 - 0.28 10.7 5.9 5.7 6.5 3.8 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus C2-C2_1 PF11618.8 EFA78942.1 - 0.016 15.3 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 First C2 domain of RPGR-interacting protein 1 C2 PF00168.30 EFA78942.1 - 0.066 13.5 0.2 0.25 11.6 0.2 2.1 1 0 0 1 1 1 0 C2 domain WD40 PF00400.32 EFA78943.1 - 1.7e-06 28.6 0.0 0.0089 16.9 0.1 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA78943.1 - 3.3e-05 24.1 0.1 1.4 9.3 0.0 3.5 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA78943.1 - 0.046 12.7 1.0 5.4 5.9 0.0 2.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFA78943.1 - 0.052 13.5 0.0 0.17 11.8 0.0 2.0 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 EFA78944.1 - 0.0075 16.2 8.8 0.13 12.2 2.4 3.3 1 1 1 2 2 2 2 Transcription factor IIIC subunit delta N-term CSS-motif PF12792.7 EFA78944.1 - 0.072 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 CSS motif domain associated with EAL CUE PF02845.16 EFA78945.1 - 2e-12 46.6 0.1 4e-12 45.6 0.1 1.6 1 0 0 1 1 1 1 CUE domain NAGLU PF05089.12 EFA78945.1 - 0.0069 15.4 1.4 0.0098 14.9 1.4 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain DUF755 PF05501.11 EFA78945.1 - 0.3 11.4 15.7 0.31 11.3 4.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) polyprenyl_synt PF00348.17 EFA78946.1 - 5.9e-56 189.4 0.1 9.5e-56 188.7 0.1 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase SPX PF03105.19 EFA78946.1 - 0.039 13.9 18.0 0.053 13.4 10.1 2.2 2 0 0 2 2 2 0 SPX domain Velvet PF11754.8 EFA78946.1 - 0.23 11.4 13.9 0.63 9.9 9.0 2.3 2 0 0 2 2 2 0 Velvet factor Macoilin PF09726.9 EFA78946.1 - 0.43 9.1 32.9 0.041 12.5 22.3 2.4 2 0 0 2 2 2 0 Macoilin family DDHD PF02862.17 EFA78946.1 - 0.85 9.7 15.2 1.4 9.0 9.6 2.5 2 0 0 2 2 2 0 DDHD domain DUF4667 PF15700.5 EFA78946.1 - 5.1 7.1 41.4 1.2 9.1 0.8 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4667) CCDC106 PF15794.5 EFA78946.1 - 5.7 6.6 25.0 0.37 10.5 16.5 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF4614 PF15391.6 EFA78946.1 - 6.6 6.7 39.8 0.35 10.9 24.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) MID_MedPIWI PF18296.1 EFA78946.1 - 8.1 6.1 20.9 4.3 7.0 12.3 2.3 2 0 0 2 2 2 0 MID domain of medPIWI AF-4 PF05110.13 EFA78946.1 - 9.1 4.2 47.0 0.25 9.4 5.5 2.3 2 0 0 2 2 2 0 AF-4 proto-oncoprotein RVT_1 PF00078.27 EFA78950.1 - 7e-29 100.9 1.1 1.3e-28 100.0 0.5 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EFA78950.1 - 9.1e-29 99.4 0.0 1.9e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA78950.1 - 7e-26 90.6 0.0 2.5e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EFA78950.1 - 1.4e-15 57.6 0.0 3.7e-15 56.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EFA78950.1 - 5.9e-14 51.9 0.5 5.9e-14 51.9 0.5 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain Asp_protease_2 PF13650.6 EFA78950.1 - 0.003 18.2 0.1 0.013 16.1 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EFA78950.1 - 0.059 13.9 0.0 0.16 12.5 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Glu-tRNAGln PF02686.15 EFA78950.1 - 0.062 13.6 0.1 0.24 11.7 0.1 2.1 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit gerPA PF10676.9 EFA78953.1 - 0.16 12.2 4.7 0.19 12.0 4.7 1.1 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF Foie-gras_1 PF11817.8 EFA78954.1 - 2.4e-10 40.4 2.6 3.4e-09 36.7 0.0 2.8 2 1 1 3 3 3 1 Foie gras liver health family 1 TPR_2 PF07719.17 EFA78954.1 - 0.15 12.3 0.3 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Menin PF05053.13 EFA78954.1 - 0.26 9.6 9.7 0.63 8.3 0.9 2.4 2 0 0 2 2 2 0 Menin Corazonin PF17308.2 EFA78954.1 - 1.5 9.2 18.3 1.2 9.5 2.3 3.7 4 0 0 4 4 4 0 Pro-corazonin TRAPPC10 PF12584.8 EFA78956.1 - 1.8e-12 47.2 0.0 3.2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF4602 PF15375.6 EFA78957.1 - 6.9e-06 26.4 11.0 9.7e-06 25.9 11.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4602) BRE1 PF08647.11 EFA78957.1 - 3.8 7.6 8.4 2.8 8.1 1.9 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Ribosomal_L32e PF01655.18 EFA78958.1 - 4.2e-46 155.8 0.1 1e-45 154.6 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L32 RNA_pol_N PF01194.17 EFA78958.1 - 2.6e-31 107.7 0.3 2.6e-31 107.7 0.3 2.0 2 0 0 2 2 2 1 RNA polymerases N / 8 kDa subunit PA_decarbox PF05870.11 EFA78958.1 - 0.055 13.1 0.1 0.18 11.4 0.0 1.8 1 1 1 2 2 2 0 Phenolic acid decarboxylase (PAD) Tissue_fac PF01108.17 EFA78959.1 - 2.5e-06 27.3 1.5 2.5e-06 27.3 1.5 2.2 3 0 0 3 3 3 1 Tissue factor EB PF01683.18 EFA78959.1 - 0.0014 18.9 0.9 0.0045 17.2 0.9 1.8 1 0 0 1 1 1 1 EB module Protocadherin PF08374.11 EFA78959.1 - 0.0026 17.8 0.1 0.0047 16.9 0.1 1.3 1 0 0 1 1 1 1 Protocadherin EGF_2 PF07974.13 EFA78959.1 - 0.0026 18.1 13.1 0.0026 18.1 13.1 2.5 2 0 0 2 2 2 1 EGF-like domain DUF5305 PF17231.2 EFA78959.1 - 0.015 14.7 0.0 0.046 13.1 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5305) fn3 PF00041.21 EFA78959.1 - 0.022 15.1 5.7 0.27 11.6 0.4 3.2 3 0 0 3 3 3 0 Fibronectin type III domain Vpu PF00558.19 EFA78959.1 - 0.048 13.4 0.5 0.093 12.5 0.5 1.4 1 0 0 1 1 1 0 Vpu protein SusE PF14292.6 EFA78959.1 - 0.1 12.8 1.7 4.8 7.5 0.4 3.0 1 1 1 2 2 2 0 SusE outer membrane protein Toxin_2 PF00451.19 EFA78959.1 - 0.14 12.5 7.7 0.36 11.2 7.7 1.8 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 EGF PF00008.27 EFA78959.1 - 1.1 9.6 11.8 0.26 11.6 7.7 2.2 2 0 0 2 2 2 0 EGF-like domain I-EGF_1 PF18372.1 EFA78959.1 - 1.2 9.3 7.2 3.2 7.9 7.2 1.8 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 CybS PF05328.12 EFA78960.1 - 5.6e-10 39.0 0.3 7.1e-10 38.7 0.3 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Metallophos PF00149.28 EFA78961.1 - 6.9e-06 26.7 0.2 1.6e-05 25.5 0.2 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA78961.1 - 0.069 13.3 0.1 0.19 11.9 0.1 1.9 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Ank_2 PF12796.7 EFA78962.1 - 9.4e-30 103.0 6.8 6.1e-06 26.7 0.0 7.3 1 1 7 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA78962.1 - 4.3e-24 84.6 5.6 0.0095 16.5 0.0 9.0 5 3 4 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA78962.1 - 4.7e-20 71.4 3.3 0.11 12.9 0.0 10.4 5 4 5 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA78962.1 - 2.5e-11 42.7 12.8 46 5.1 0.0 13.6 14 2 2 16 16 16 0 Ankyrin repeat DUF249 PF03158.13 EFA78962.1 - 0.051 13.3 2.4 0.75 9.5 0.0 3.7 4 1 0 4 4 4 0 Multigene family 530 protein CAP PF00188.26 EFA78963.1 - 3.4e-14 53.7 0.3 4.1e-14 53.5 0.3 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF3854 PF12965.7 EFA78964.1 - 0.054 13.5 0.0 0.059 13.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) CFTR_R PF14396.6 EFA78965.1 - 0.011 15.3 0.1 0.023 14.3 0.1 1.4 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain APOBEC4 PF18775.1 EFA78965.1 - 0.023 14.8 0.4 0.17 12.0 0.1 2.6 2 0 0 2 2 2 0 APOBEC4 Ricin_B_lectin PF00652.22 EFA78966.1 - 1.5e-09 38.2 1.1 0.00026 21.2 0.0 3.0 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 EFA78966.1 - 8.6e-05 22.2 1.0 0.13 11.8 0.0 2.6 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain RicinB_lectin_2 PF14200.6 EFA78966.1 - 0.0053 17.4 8.4 1.5 9.6 1.1 4.5 4 2 0 4 4 4 2 Ricin-type beta-trefoil lectin domain-like Laminin_G_3 PF13385.6 EFA78967.1 - 2.1e-08 34.4 3.6 4.8e-08 33.3 3.6 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EFA78967.1 - 9.3e-07 29.5 0.0 1.9e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EFA78967.1 - 0.006 16.8 0.1 0.011 15.9 0.1 1.5 1 0 0 1 1 1 1 Laminin G domain QRPTase_N PF02749.16 EFA78969.1 - 3.9e-05 23.6 0.0 5.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain F-box_5 PF18511.1 EFA78971.1 - 1.1e-05 24.9 0.1 1.9e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 F-box Csm1_B PF18211.1 EFA78971.1 - 0.0017 18.1 0.2 0.0028 17.5 0.1 1.4 1 1 0 1 1 1 1 Csm1 subunit domain B F-box-like PF12937.7 EFA78971.1 - 0.0048 16.8 0.1 0.008 16.0 0.1 1.4 1 0 0 1 1 1 1 F-box-like FNIP PF05725.12 EFA78972.1 - 9.6e-15 54.5 21.7 7.3e-10 38.9 0.4 8.6 5 2 2 7 7 7 4 FNIP Repeat Peptidase_M8 PF01457.16 EFA78973.1 - 3.4e-55 187.7 0.9 6.5e-55 186.8 0.9 1.4 1 1 0 1 1 1 1 Leishmanolysin FNIP PF05725.12 EFA78974.1 - 2e-92 303.1 97.2 9.4e-16 57.7 0.3 21.3 16 6 5 22 22 22 16 FNIP Repeat F-box_5 PF18511.1 EFA78974.1 - 9.1e-12 44.3 5.5 1.2e-05 24.8 1.1 2.6 2 0 0 2 2 2 2 F-box F-box-like PF12937.7 EFA78974.1 - 1.1e-06 28.4 5.7 0.024 14.5 0.2 3.6 3 0 0 3 3 3 2 F-box-like Gal4_dimer PF03902.13 EFA78974.1 - 0.0066 16.6 2.9 30 4.9 0.1 3.9 3 0 0 3 3 3 0 Gal4-like dimerisation domain Neur PF00064.18 EFA78974.1 - 0.026 13.3 1.4 3.4 6.4 0.1 2.6 3 0 0 3 3 3 0 Neuraminidase Endonuc-PvuII PF09225.10 EFA78974.1 - 0.028 14.2 0.0 10 5.8 0.0 3.1 3 0 0 3 3 3 0 Restriction endonuclease PvuII LPD24 PF18839.1 EFA78974.1 - 0.092 13.0 0.5 23 5.3 0.0 2.8 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 GLYCAM-1 PF05242.11 EFA78974.1 - 0.22 11.6 1.9 0.71 10.0 0.4 2.3 2 0 0 2 2 2 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) FNIP PF05725.12 EFA78975.1 - 3e-24 84.9 20.3 1.3e-11 44.5 0.0 7.6 6 2 1 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA78975.1 - 2.6e-05 23.7 0.2 6.6e-05 22.4 0.2 1.7 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA78975.1 - 0.0008 19.3 0.2 0.0023 17.8 0.2 1.8 1 0 0 1 1 1 1 F-box-like Gal4_dimer PF03902.13 EFA78975.1 - 0.17 12.1 0.6 4.2 7.6 0.1 2.7 2 0 0 2 2 2 0 Gal4-like dimerisation domain FNIP PF05725.12 EFA78976.1 - 2.5e-05 24.3 0.7 2.5e-05 24.3 0.7 2.0 2 0 0 2 2 2 1 FNIP Repeat B_lectin PF01453.24 EFA78976.1 - 0.12 13.0 0.0 1.7 9.2 0.0 2.5 2 0 0 2 2 2 0 D-mannose binding lectin Ricin_B_lectin PF00652.22 EFA78976.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain Mucin PF01456.17 EFA78977.1 - 0.0002 21.4 9.5 0.00034 20.6 9.5 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein N6_N4_Mtase PF01555.18 EFA78977.1 - 0.0012 18.7 0.0 0.0012 18.7 0.0 2.8 3 0 0 3 3 3 1 DNA methylase UPF0020 PF01170.18 EFA78977.1 - 0.037 13.7 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Sporozoite_P67 PF05642.11 EFA78977.1 - 0.82 7.7 15.7 1.3 7.0 15.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen EF-hand_1 PF00036.32 EFA78978.1 - 3e-20 70.2 2.8 2.2e-06 26.8 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFA78978.1 - 8.6e-17 61.4 1.5 4.9e-09 36.5 0.4 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA78978.1 - 1.5e-15 55.7 2.4 3.7e-06 26.4 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFA78978.1 - 1.3e-08 34.0 4.4 1.3e-05 24.4 0.1 4.3 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 EFA78978.1 - 2.4e-08 33.7 4.3 0.00051 19.8 1.3 4.4 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA78978.1 - 0.00017 21.9 0.4 0.092 13.1 0.1 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFA78978.1 - 0.0008 19.7 0.1 0.039 14.3 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain M16C_assoc PF08367.11 EFA78978.1 - 0.00099 18.3 0.7 0.0014 17.8 0.7 1.4 1 1 0 1 1 1 1 Peptidase M16C associated Dockerin_1 PF00404.18 EFA78978.1 - 0.0053 16.9 0.2 0.27 11.4 0.3 2.6 1 1 1 2 2 2 1 Dockerin type I domain Sigma70_r1_1 PF03979.14 EFA78978.1 - 0.022 14.8 0.6 0.84 9.7 0.1 2.7 2 1 1 3 3 3 0 Sigma-70 factor, region 1.1 EF-hand_2 PF09068.11 EFA78978.1 - 0.059 13.5 1.5 3.8 7.7 0.0 2.4 3 0 0 3 3 3 0 EF hand OTU PF02338.19 EFA78979.1 - 3.7e-18 66.3 0.0 9.9e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease PRP38_assoc PF12871.7 EFA78979.1 - 2.6 8.7 34.1 0.13 12.9 11.2 3.2 3 0 0 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Y_phosphatase2 PF03162.13 EFA78980.1 - 4.6e-62 208.4 0.0 5.2e-62 208.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFA78980.1 - 2e-07 31.2 0.0 2.8e-07 30.8 0.0 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EFA78980.1 - 9.5e-05 22.2 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA78980.1 - 0.0016 18.0 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FNIP PF05725.12 EFA78981.1 - 2.4e-17 62.8 4.3 2.3e-12 46.9 0.5 2.5 2 0 0 2 2 2 2 FNIP Repeat LIM PF00412.22 EFA78981.1 - 6.4e-10 39.1 5.2 1.2e-09 38.2 5.2 1.5 1 0 0 1 1 1 1 LIM domain Endotoxin_N PF03945.14 EFA78982.1 - 1.1e-12 48.2 1.5 2.3e-12 47.1 1.5 1.5 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Ricin_B_lectin PF00652.22 EFA78982.1 - 5.2e-10 39.7 0.9 1.3e-05 25.4 0.1 2.7 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 EFA78982.1 - 9.7e-05 22.0 1.7 0.046 13.3 0.0 2.7 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain Aminopep PF10023.9 EFA78982.1 - 0.045 13.1 0.3 0.075 12.4 0.3 1.3 1 0 0 1 1 1 0 Putative aminopeptidase RicinB_lectin_2 PF14200.6 EFA78982.1 - 0.11 13.3 13.7 0.16 12.7 0.1 4.5 5 0 0 5 5 5 0 Ricin-type beta-trefoil lectin domain-like Suf PF05843.14 EFA78984.1 - 3.2e-83 280.1 0.0 3.2e-83 280.1 0.0 5.4 3 1 2 5 5 5 2 Suppressor of forked protein (Suf) HAT PF02184.16 EFA78984.1 - 0.0014 18.6 1.4 0.16 12.0 0.0 3.4 2 1 0 2 2 2 1 HAT (Half-A-TPR) repeat TPR_6 PF13174.6 EFA78984.1 - 0.16 12.7 1.5 2.2e+02 2.8 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFA78984.1 - 0.21 11.6 0.1 0.21 11.6 0.1 3.1 3 1 0 3 3 3 0 Mad3/BUB1 homology region 1 EamA PF00892.20 EFA78985.1 - 0.018 15.2 8.2 0.018 15.2 8.2 2.2 2 0 0 2 2 2 0 EamA-like transporter family Mago_nashi PF02792.14 EFA78985.1 - 0.13 12.4 2.7 0.28 11.3 2.7 1.5 1 0 0 1 1 1 0 Mago nashi protein 7tm_3 PF00003.22 EFA78986.1 - 1.4e-41 142.8 16.6 2.8e-41 141.8 16.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA78986.1 - 4.5e-20 71.8 2.2 6.1e-20 71.4 2.2 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like DUF347 PF03988.12 EFA78986.1 - 0.11 12.7 0.4 0.11 12.7 0.4 4.1 5 0 0 5 5 5 0 Repeat of Unknown Function (DUF347) DUF1980 PF09323.10 EFA78986.1 - 0.12 12.3 3.6 0.91 9.4 3.5 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) EXS PF03124.14 EFA78986.1 - 3.9 6.7 9.1 0.65 9.3 1.6 2.3 2 0 0 2 2 2 0 EXS family 7tm_3 PF00003.22 EFA78987.1 - 9.5e-41 140.1 18.4 1.5e-40 139.4 18.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA78987.1 - 2.7e-10 39.7 0.1 4.3e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like EXS PF03124.14 EFA78987.1 - 0.55 9.5 6.9 2.2 7.6 0.4 2.3 2 0 0 2 2 2 0 EXS family ArAE_2_N PF10337.9 EFA78987.1 - 0.64 9.0 6.9 0.086 11.9 2.3 1.7 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal AICARFT_IMPCHas PF01808.18 EFA78988.1 - 2e-109 365.6 0.0 2.8e-109 365.1 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EFA78988.1 - 1.5e-23 82.8 0.0 4.3e-23 81.3 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain Peptidase_C92 PF05708.12 EFA78988.1 - 0.12 12.4 0.0 0.64 10.1 0.0 2.1 2 0 0 2 2 2 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Pex14_N PF04695.13 EFA78989.1 - 0.046 14.4 9.5 0.066 13.9 9.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 EFA78989.1 - 0.056 12.6 4.3 0.068 12.4 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 EFA78989.1 - 1.5 8.6 8.9 1.8 8.3 8.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TIG PF01833.24 EFA78990.1 - 1.5e-05 25.0 21.1 0.0051 16.9 5.2 4.7 4 1 1 5 5 5 2 IPT/TIG domain EGF_2 PF07974.13 EFA78990.1 - 0.01 16.2 14.5 0.01 16.2 14.5 2.0 2 0 0 2 2 2 0 EGF-like domain VIT_2 PF13757.6 EFA78990.1 - 0.12 12.3 0.2 9.5 6.2 0.1 2.7 1 1 1 2 2 2 0 Vault protein inter-alpha-trypsin domain Dicty_CTDC PF00526.18 EFA78991.1 - 6.1e-12 45.2 53.1 1.1e-06 28.4 6.4 15.3 15 0 0 15 15 15 10 Dictyostelium (slime mold) repeat PA14 PF07691.12 EFA78991.1 - 1.5e-06 28.1 0.0 2.5e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Keratin_assoc PF09775.9 EFA78993.1 - 4.4e-29 100.8 7.6 7.7e-29 100.0 7.6 1.4 1 1 0 1 1 1 1 Keratinocyte-associated protein 2 Peptidase_M50B PF13398.6 EFA78993.1 - 0.2 11.3 7.3 0.076 12.6 4.4 1.6 1 1 1 2 2 2 0 Peptidase M50B-like Wzy_C PF04932.15 EFA78993.1 - 0.22 11.1 5.2 0.45 10.1 5.2 1.5 1 1 0 1 1 1 0 O-Antigen ligase zf-RING_2 PF13639.6 EFA78995.1 - 2.5e-12 46.9 8.2 4e-12 46.3 8.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA78995.1 - 1.4e-10 40.9 6.2 2.4e-10 40.1 6.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA78995.1 - 1.9e-08 34.5 8.5 7.9e-08 32.5 8.4 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFA78995.1 - 1.5e-07 31.2 6.7 3e-07 30.2 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA78995.1 - 1.7e-06 27.7 4.0 3.6e-06 26.6 4.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EFA78995.1 - 1.3e-05 25.0 3.8 1.9e-05 24.4 3.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA78995.1 - 2.1e-05 24.5 3.4 4.7e-05 23.3 3.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Baculo_RING PF05883.11 EFA78995.1 - 0.00079 19.4 2.6 0.002 18.1 2.6 1.6 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain zf-RING_5 PF14634.6 EFA78995.1 - 0.0013 18.6 4.9 0.0025 17.7 4.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EFA78995.1 - 0.0036 17.3 4.6 0.014 15.4 4.6 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger TFIIA PF03153.13 EFA78995.1 - 0.0042 17.1 20.5 0.0052 16.8 20.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Zn_ribbon_17 PF17120.5 EFA78995.1 - 0.029 14.0 4.4 0.058 13.0 4.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EFA78995.1 - 0.045 13.6 4.9 0.093 12.6 4.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 EFA78995.1 - 0.098 12.8 5.8 0.2 11.8 5.8 1.6 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EFA78995.1 - 0.11 12.3 3.2 0.27 11.1 3.2 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EFA78995.1 - 0.16 11.8 5.4 0.34 10.7 5.3 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EFA78995.1 - 0.16 11.9 5.6 0.32 10.9 5.6 1.5 1 0 0 1 1 1 0 PHD-finger Hamartin PF04388.12 EFA78995.1 - 0.28 9.8 27.0 0.36 9.5 27.0 1.1 1 0 0 1 1 1 0 Hamartin protein zf-C3HC4_4 PF15227.6 EFA78995.1 - 0.79 9.9 4.6 2 8.6 4.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Tir_receptor_C PF07489.11 EFA78995.1 - 0.93 9.4 25.2 1.3 8.9 14.3 2.3 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus FANCL_C PF11793.8 EFA78995.1 - 0.97 9.7 9.0 6.9 6.9 9.0 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Di19 PF05605.12 EFA78995.1 - 1.8 9.0 6.8 4 7.8 1.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding SOG2 PF10428.9 EFA78995.1 - 3.3 6.8 26.7 4.8 6.3 26.7 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein zf-RING-like PF08746.11 EFA78995.1 - 8.2 6.8 8.9 0.51 10.7 3.7 1.7 2 0 0 2 2 1 0 RING-like domain CK_II_beta PF01214.18 EFA78996.1 - 8.1e-80 266.9 0.0 9.9e-80 266.6 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CxC5 PF18718.1 EFA78996.1 - 0.018 15.1 0.1 0.033 14.3 0.1 1.4 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases Sep15_SelM PF08806.11 EFA78998.1 - 5.4e-09 36.1 0.2 1.2e-08 35.0 0.1 1.6 1 1 0 1 1 1 1 Sep15/SelM redox domain Tat PF00539.18 EFA78998.1 - 0.058 13.6 0.9 0.48 10.6 0.0 2.5 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) Endonuclease_7 PF02945.15 EFA78998.1 - 0.73 9.8 3.9 0.35 10.8 1.2 1.8 2 1 0 2 2 2 0 Recombination endonuclease VII ACC_central PF08326.12 EFA78999.1 - 2.1e-187 624.7 8.4 2.9e-187 624.2 8.4 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EFA78999.1 - 9.6e-162 539.0 0.0 1.6e-161 538.3 0.0 1.4 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EFA78999.1 - 8.5e-51 172.5 0.0 1.6e-50 171.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFA78999.1 - 3e-29 101.8 0.1 7.8e-29 100.4 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFA78999.1 - 1.1e-18 67.3 0.0 2.6e-18 66.1 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFA78999.1 - 4.5e-08 32.8 0.0 9.6e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 EFA78999.1 - 5e-05 22.9 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFA78999.1 - 0.00022 20.8 0.0 0.00048 19.7 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFA78999.1 - 0.00046 20.3 0.0 0.0014 18.7 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain CBM49 PF09478.10 EFA79000.1 - 1.2e-07 31.9 0.5 1.1e-06 28.9 0.5 2.0 1 1 0 1 1 1 1 Carbohydrate binding domain CBM49 DUF4564 PF15169.6 EFA79001.1 - 1.7e-36 125.7 0.3 2e-36 125.4 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) MFS_1 PF07690.16 EFA79002.1 - 2.6e-21 75.9 21.3 3.6e-21 75.5 21.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5010 PF16402.5 EFA79002.1 - 0.044 12.6 0.0 0.068 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5010) Peptidase_C1 PF00112.23 EFA79003.1 - 4.8e-43 147.8 0.3 6.5e-43 147.3 0.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Proteasome PF00227.26 EFA79004.1 - 2.5e-50 170.6 0.0 3.1e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA79004.1 - 1e-09 37.9 0.1 1.6e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Homeodomain PF00046.29 EFA79004.1 - 0.063 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Homeodomain START PF01852.19 EFA79005.1 - 1.7e-05 24.3 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 START domain YfhO PF09586.10 EFA79005.1 - 0.0053 15.1 1.7 0.0094 14.2 1.7 1.3 1 0 0 1 1 1 1 Bacterial membrane protein YfhO PI3K_p85B PF02192.16 EFA79005.1 - 0.1 12.4 0.3 0.39 10.5 0.2 2.1 1 1 0 1 1 1 0 PI3-kinase family, p85-binding domain Herpes_IE1 PF07340.11 EFA79005.1 - 0.11 11.4 0.1 0.18 10.7 0.1 1.3 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein DUF1132 PF06575.12 EFA79006.1 - 0.0073 16.7 0.3 0.022 15.2 0.2 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1132) Laminin_G_3 PF13385.6 EFA79007.1 - 8.4e-21 74.7 5.3 8.4e-21 74.7 2.3 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Endotoxin_N PF03945.14 EFA79007.1 - 6.8e-14 52.1 2.2 1.3e-13 51.1 2.2 1.5 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Laminin_G_2 PF02210.24 EFA79007.1 - 4.1e-09 37.1 0.0 7.8e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EFA79007.1 - 0.0012 19.0 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Pentaxin PF00354.17 EFA79007.1 - 0.0028 17.4 0.1 0.0061 16.3 0.1 1.5 1 0 0 1 1 1 1 Pentaxin family Endotoxin_N PF03945.14 EFA79008.1 - 2e-13 50.6 0.4 3.8e-13 49.7 0.4 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Laminin_G_3 PF13385.6 EFA79008.1 - 4.9e-06 26.8 0.2 1.1e-05 25.7 0.2 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EFA79008.1 - 0.013 16.1 0.0 0.029 15.0 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain FNIP PF05725.12 EFA79012.1 - 2.1e-46 155.8 28.8 3.4e-15 55.9 3.4 7.3 3 1 7 10 10 10 8 FNIP Repeat F-box_5 PF18511.1 EFA79012.1 - 6.4e-06 25.6 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 F-box Laminin_G_3 PF13385.6 EFA79014.1 - 5.2e-18 65.7 4.5 5.2e-18 65.7 4.5 2.9 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Endotoxin_N PF03945.14 EFA79014.1 - 5e-12 46.0 2.0 9.4e-12 45.1 2.0 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Laminin_G_2 PF02210.24 EFA79014.1 - 4.8e-11 43.3 0.2 1.3e-10 41.9 0.2 1.8 1 0 0 1 1 1 1 Laminin G domain Ricin_B_lectin PF00652.22 EFA79014.1 - 1.9e-09 37.8 1.4 0.00014 22.1 0.2 2.7 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain Laminin_G_1 PF00054.23 EFA79014.1 - 5.1e-05 23.5 0.1 0.00011 22.4 0.1 1.5 1 0 0 1 1 1 1 Laminin G domain CDtoxinA PF03498.14 EFA79014.1 - 0.00016 21.3 1.0 0.095 12.3 0.0 2.7 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain LPD18 PF18832.1 EFA79014.1 - 0.099 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 18 Aminopep PF10023.9 EFA79014.1 - 0.12 11.7 0.2 0.2 11.0 0.2 1.3 1 0 0 1 1 1 0 Putative aminopeptidase RicinB_lectin_2 PF14200.6 EFA79014.1 - 2 9.2 20.5 1.4 9.7 0.0 5.9 7 0 0 7 7 7 0 Ricin-type beta-trefoil lectin domain-like Kelch_6 PF13964.6 EFA79015.1 - 0.00091 19.4 0.5 0.38 11.1 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 EFA79015.1 - 0.079 12.6 2.1 0.71 9.5 0.3 2.4 2 0 0 2 2 2 0 Kelch motif QRPTase_C PF01729.19 EFA79016.1 - 1.7e-53 180.8 0.0 2.2e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EFA79016.1 - 5.4e-17 61.6 0.0 1.4e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain TIG PF01833.24 EFA79017.1 - 2.1e-67 223.2 91.8 2.3e-11 43.6 1.5 14.6 13 2 2 15 15 15 12 IPT/TIG domain DNase_II PF03265.15 EFA79017.1 - 1.2e-29 103.6 2.0 1.2e-18 67.5 1.3 2.6 2 0 0 2 2 2 2 Deoxyribonuclease II Laminin_G_3 PF13385.6 EFA79017.1 - 6.2e-07 29.7 4.1 6.2e-07 29.7 4.1 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EFA79017.1 - 6.3e-06 26.8 0.0 2.6e-05 24.8 0.0 2.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EFA79017.1 - 0.031 14.5 0.1 0.11 12.8 0.1 1.9 1 0 0 1 1 1 0 Laminin G domain Ricin_B_lectin PF00652.22 EFA79018.1 - 1.8e-09 37.9 1.0 0.00027 21.2 0.0 2.8 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 EFA79018.1 - 5.7e-05 22.7 1.4 0.14 11.8 0.0 3.0 3 0 0 3 3 3 2 Cytolethal distending toxin A/C domain RicinB_lectin_2 PF14200.6 EFA79018.1 - 0.0013 19.4 5.8 2 9.2 1.3 4.1 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like B_lectin PF01453.24 EFA79018.1 - 0.41 11.2 5.0 1.1 9.8 0.1 3.8 4 1 1 5 5 5 0 D-mannose binding lectin QRPTase_C PF01729.19 EFA79019.1 - 1.9e-25 89.6 0.0 2.5e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Laminin_G_3 PF13385.6 EFA79020.1 - 2.9e-17 63.2 0.8 2.9e-17 63.2 0.8 3.0 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Ricin_B_lectin PF00652.22 EFA79020.1 - 1.8e-09 37.9 0.6 4.2e-05 23.8 0.1 2.6 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain Laminin_G_2 PF02210.24 EFA79020.1 - 9.2e-08 32.7 0.1 3.2e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Laminin G domain CDtoxinA PF03498.14 EFA79020.1 - 0.00024 20.7 0.5 0.074 12.6 0.0 2.7 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain RicinB_lectin_2 PF14200.6 EFA79020.1 - 0.00062 20.5 6.8 0.27 12.0 0.0 4.9 5 0 0 5 5 5 2 Ricin-type beta-trefoil lectin domain-like Ank_3 PF13606.6 EFA79022.1 - 2.3e-06 27.5 4.2 0.43 11.3 0.0 7.6 9 0 0 9 9 9 2 Ankyrin repeat Ank_2 PF12796.7 EFA79022.1 - 2.7e-05 24.7 3.9 0.1 13.2 0.0 5.6 4 2 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79022.1 - 0.0023 18.5 0.2 6.8 7.4 0.0 5.1 5 0 0 5 5 5 1 Ankyrin repeats (many copies) FNIP PF05725.12 EFA79023.1 - 3.6e-28 97.5 28.8 7e-14 51.7 0.7 7.5 5 2 1 6 6 6 6 FNIP Repeat STAT2_C PF12188.8 EFA79023.1 - 0.69 9.9 7.3 1.4 8.9 0.1 3.8 4 0 0 4 4 4 0 Signal transducer and activator of transcription 2 C terminal DUF3430 PF11912.8 EFA79024.1 - 1e-06 28.9 36.0 1.8e-06 28.2 36.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3430) DUF3586 PF12131.8 EFA79024.1 - 4.6 7.5 15.0 0.2 11.9 1.4 3.2 3 2 1 4 4 4 0 Protein of unknown function (DUF3586) EGF_2 PF07974.13 EFA79025.1 - 1.5e-07 31.7 32.6 0.0015 18.8 13.9 2.8 2 0 0 2 2 2 2 EGF-like domain EGF_Tenascin PF18720.1 EFA79025.1 - 0.004 17.2 33.3 0.11 12.5 10.6 3.6 3 0 0 3 3 3 2 Tenascin EGF domain CEND1 PF15677.5 EFA79025.1 - 0.027 15.0 0.1 0.05 14.1 0.1 1.3 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 hEGF PF12661.7 EFA79025.1 - 0.33 11.7 17.7 1.6 9.4 5.0 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFA79025.1 - 0.97 9.8 22.9 3.8 7.9 7.7 2.6 2 0 0 2 2 2 0 EGF-like domain Laminin_G_3 PF13385.6 EFA79027.1 - 4.7e-17 62.5 4.4 4.7e-17 62.5 4.4 3.4 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Endotoxin_N PF03945.14 EFA79027.1 - 2.2e-12 47.2 1.1 4.7e-12 46.1 1.1 1.6 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Ricin_B_lectin PF00652.22 EFA79027.1 - 9.9e-09 35.5 1.7 0.00013 22.3 0.1 2.6 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Laminin_G_2 PF02210.24 EFA79027.1 - 2.5e-08 34.6 0.0 6.3e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain Pentaxin PF00354.17 EFA79027.1 - 0.0006 19.6 1.0 0.034 13.8 0.2 2.5 2 0 0 2 2 2 1 Pentaxin family CDtoxinA PF03498.14 EFA79027.1 - 0.00061 19.4 1.1 0.38 10.3 0.0 2.8 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain Laminin_G_1 PF00054.23 EFA79027.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain RicinB_lectin_2 PF14200.6 EFA79027.1 - 0.34 11.7 13.2 5.4 7.8 0.4 5.3 4 1 1 5 5 5 0 Ricin-type beta-trefoil lectin domain-like HAD PF12710.7 EFA79028.1 - 3e-19 70.2 0.0 4.7e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFA79028.1 - 2.6e-08 34.4 0.0 5.4e-08 33.4 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA79028.1 - 1e-06 28.7 1.2 6.9e-06 26.0 0.0 2.7 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EFA79028.1 - 5.3e-05 22.7 0.1 0.00019 20.9 0.0 1.8 2 0 0 2 2 2 1 Putative Phosphatase Redoxin PF08534.10 EFA79029.1 - 1.9e-12 47.1 0.0 2.5e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EFA79029.1 - 0.00023 21.1 0.0 0.0003 20.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family PH PF00169.29 EFA79030.1 - 1.4e-10 41.6 0.1 2.7e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EFA79030.1 - 0.00039 20.5 0.1 0.0006 19.9 0.1 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFA79030.1 - 0.0017 18.6 0.3 0.0025 18.1 0.3 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFA79030.1 - 3 8.3 10.8 0.071 13.5 3.5 2.0 2 1 0 2 2 2 0 Pleckstrin homology domain Glyco_hydro_63 PF03200.16 EFA79031.1 - 2.5e-08 33.1 12.6 1.1e-07 31.0 5.3 4.2 3 1 0 3 3 3 1 Glycosyl hydrolase family 63 C-terminal domain FlhC PF05280.11 EFA79031.1 - 0.051 13.3 0.0 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 Flagellar transcriptional activator (FlhC) VWA_3 PF13768.6 EFA79032.1 - 5.9e-20 71.8 0.0 1.5e-19 70.5 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain VIT PF08487.10 EFA79032.1 - 8.8e-19 67.8 0.5 2.3e-18 66.4 0.5 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EFA79032.1 - 3.9e-15 56.5 0.5 9.3e-15 55.3 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA79032.1 - 1.7e-08 35.1 0.0 5.6e-08 33.4 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain Deltameth_res PF16020.5 EFA79032.1 - 0.0061 16.4 0.7 2.3 8.1 0.0 3.0 2 0 0 2 2 2 2 Deltamethrin resistance FNIP PF05725.12 EFA79034.1 - 8.6e-32 109.1 4.6 1.9e-14 53.6 0.0 10.3 5 3 5 11 11 11 6 FNIP Repeat F-box_5 PF18511.1 EFA79034.1 - 5.3e-08 32.3 0.4 1.4e-07 30.9 0.4 1.7 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA79034.1 - 0.0001 22.1 0.3 0.0003 20.6 0.3 1.8 1 0 0 1 1 1 1 F-box-like DUF538 PF04398.12 EFA79034.1 - 0.061 13.8 0.0 2.3 8.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF538 FNIP PF05725.12 EFA79036.1 - 2.1e-24 85.4 31.1 3.8e-10 39.8 1.0 9.2 7 3 4 11 11 11 3 FNIP Repeat F-box_5 PF18511.1 EFA79036.1 - 5.3e-13 48.3 8.1 2.4e-07 30.2 0.9 2.9 2 1 0 2 2 2 2 F-box F-box-like PF12937.7 EFA79036.1 - 4.3e-07 29.7 2.0 0.00073 19.4 0.4 2.8 2 0 0 2 2 2 2 F-box-like PvlArgDC PF01862.16 EFA79036.1 - 0.09 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) F-box PF00646.33 EFA79036.1 - 0.19 11.6 4.4 9.6 6.2 1.2 2.9 2 0 0 2 2 2 0 F-box domain F-box_5 PF18511.1 EFA79038.1 - 9.5e-08 31.5 0.5 2.6e-07 30.1 0.5 1.7 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA79038.1 - 0.001 18.9 0.1 0.0034 17.2 0.1 1.9 1 0 0 1 1 1 1 F-box-like FNIP PF05725.12 EFA79038.1 - 0.0017 18.5 20.2 0.086 13.0 1.2 4.7 5 1 0 5 5 5 3 FNIP Repeat LRR_4 PF12799.7 EFA79038.1 - 1.6 9.3 14.5 0.23 12.0 3.2 4.6 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 EFA79039.1 - 7.2e-10 38.9 16.0 2.5e-05 24.4 0.2 5.7 5 1 0 6 6 6 4 FNIP Repeat ACT_7 PF13840.6 EFA79039.1 - 0.083 12.7 0.1 1.1 9.0 0.0 2.3 1 1 1 2 2 2 0 ACT domain Sad1_UNC PF07738.13 EFA79040.1 - 4.9e-20 71.9 0.2 1.8e-19 70.1 0.2 2.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF3042 PF11240.8 EFA79040.1 - 9.1 6.4 8.3 0.84 9.7 1.5 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) MMM1 PF10296.9 EFA79041.1 - 2.3e-13 49.9 0.7 2.3e-13 49.9 0.7 2.6 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 DUF4834 PF16118.5 EFA79041.1 - 0.037 15.0 0.1 0.037 15.0 0.1 3.3 2 1 1 3 3 2 0 Domain of unknown function (DUF4834) FPN1 PF06963.12 EFA79041.1 - 0.16 10.5 0.0 0.16 10.5 0.0 1.6 2 0 0 2 2 2 0 Ferroportin1 (FPN1) Zip PF02535.22 EFA79041.1 - 0.19 10.9 7.9 3 7.0 0.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Connexin PF00029.19 EFA79041.1 - 0.34 10.6 2.4 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Connexin Ctr PF04145.15 EFA79041.1 - 0.41 11.3 0.0 0.41 11.3 0.0 2.7 2 1 0 2 2 1 0 Ctr copper transporter family Menin PF05053.13 EFA79041.1 - 0.67 8.3 21.0 0.73 8.1 12.2 2.0 2 0 0 2 2 2 0 Menin Phostensin_N PF13916.6 EFA79041.1 - 1.4 9.3 3.9 0.88 10.0 0.2 2.2 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Suf PF05843.14 EFA79041.1 - 3.8 7.4 11.8 3.4 7.6 6.4 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF572 PF04502.13 EFA79041.1 - 4.8 6.7 14.2 2.3 7.7 7.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Presenilin PF01080.17 EFA79041.1 - 5.4 5.7 15.1 20 3.8 0.1 2.2 2 0 0 2 2 2 0 Presenilin TIP41 PF04176.13 EFA79042.1 - 3.5e-60 202.4 0.1 6e-60 201.6 0.1 1.4 1 0 0 1 1 1 1 TIP41-like family DUF775 PF05603.12 EFA79042.1 - 2.2e-32 112.2 4.1 3.5e-32 111.6 4.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF775) cobW PF02492.19 EFA79044.1 - 7.8e-14 51.7 1.3 8.2e-06 25.5 0.0 2.7 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFA79044.1 - 0.0031 17.4 0.0 0.0073 16.2 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain dNK PF01712.19 EFA79044.1 - 0.0067 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_33 PF13671.6 EFA79044.1 - 0.015 15.5 0.0 0.04 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain MAP70 PF07058.11 EFA79044.1 - 0.022 13.5 0.9 0.03 13.1 0.9 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 RsgA_GTPase PF03193.16 EFA79044.1 - 0.089 12.7 0.1 0.6 10.0 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase G10 PF01125.17 EFA79045.1 - 0.00041 20.1 17.3 0.00041 20.1 17.3 3.6 4 0 0 4 4 4 2 G10 protein dCMP_cyt_deam_1 PF00383.23 EFA79046.1 - 4.5e-11 42.5 3.5 6.2e-10 38.9 0.0 2.3 1 1 1 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFA79046.1 - 7.2e-09 35.5 0.4 4.8e-08 32.8 0.0 2.4 2 1 0 2 2 2 1 MafB19-like deaminase SNAD4 PF18750.1 EFA79046.1 - 0.06 13.5 3.6 0.79 9.9 0.1 2.3 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 EFA79046.1 - 0.073 13.1 1.6 0.48 10.5 1.6 2.0 1 1 0 1 1 1 0 Bd3614-like deaminase APOBEC2 PF18772.1 EFA79046.1 - 2.2 8.3 5.2 5 7.1 0.3 2.2 1 1 0 2 2 2 0 APOBEC2 NAD1 PF18778.1 EFA79046.1 - 4.7 7.3 6.5 2.6 8.1 0.4 2.3 1 1 1 2 2 2 0 Novel AID APOBEC clade 1 SBF PF01758.16 EFA79047.1 - 1.1e-45 155.7 13.3 1.1e-45 155.7 13.3 2.1 3 0 0 3 3 3 1 Sodium Bile acid symporter family LMWPc PF01451.21 EFA79047.1 - 7e-15 55.6 0.2 1.9e-14 54.2 0.2 1.7 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase SBF_like PF13593.6 EFA79047.1 - 7.8e-07 28.7 20.2 1.4e-06 27.8 20.1 1.4 1 1 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Ras PF00071.22 EFA79048.1 - 7.1e-53 178.5 0.1 8.8e-53 178.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA79048.1 - 1.3e-18 67.3 0.0 2.3e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA79048.1 - 5.5e-10 39.0 0.0 7.4e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA79048.1 - 1e-06 28.5 0.0 2.3e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA79048.1 - 8.8e-06 25.7 0.1 0.015 15.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA79048.1 - 0.00089 19.3 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA79048.1 - 0.0032 17.0 0.1 0.021 14.3 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EFA79048.1 - 0.028 13.8 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFA79048.1 - 0.042 13.3 0.1 0.054 12.9 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RhoGAP PF00620.27 EFA79049.1 - 7.4e-35 120.0 0.6 4.9e-34 117.4 0.6 2.6 1 0 0 1 1 1 1 RhoGAP domain BAR_3 PF16746.5 EFA79049.1 - 3.5e-14 53.1 6.0 3.5e-14 53.1 6.0 5.4 7 0 0 7 7 7 1 BAR domain of APPL family Pro_isomerase PF00160.21 EFA79050.1 - 2.3e-16 60.4 8.8 3.1e-16 60.0 0.0 3.6 2 2 1 3 3 3 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4604 PF15377.6 EFA79050.1 - 0.017 15.5 0.1 0.017 15.5 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4604) Dmrt1 PF12374.8 EFA79050.1 - 0.17 12.4 3.0 0.49 10.9 3.0 1.7 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 Mitofilin PF09731.9 EFA79050.1 - 0.22 10.3 25.4 0.3 9.9 25.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein HNF-1_N PF04814.13 EFA79050.1 - 0.94 10.1 17.5 0.34 11.5 14.9 1.5 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus GIDA PF01134.22 EFA79050.1 - 0.99 8.4 6.4 1.6 7.8 6.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A YfhO PF09586.10 EFA79050.1 - 5.6 5.1 15.2 6.8 4.8 15.2 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Calreticulin PF00262.18 EFA79051.1 - 3.7e-82 276.1 21.5 2.6e-60 204.2 1.6 2.5 2 1 1 3 3 3 2 Calreticulin family MDM10 PF12519.8 EFA79051.1 - 0.073 11.9 3.7 0.11 11.3 3.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 U79_P34 PF03064.16 EFA79051.1 - 0.24 10.8 3.7 0.37 10.1 3.7 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 RPN7 PF10602.9 EFA79052.1 - 1.1e-51 175.0 0.2 2.1e-51 174.1 0.2 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFA79052.1 - 3e-18 66.2 1.2 7.7e-18 64.9 1.2 1.7 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 EFA79052.1 - 1.4e-05 24.9 0.5 0.0025 17.8 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA79052.1 - 0.00018 21.1 0.4 0.0022 17.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA79052.1 - 0.0049 17.1 0.0 0.078 13.3 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Vac_Fusion PF02346.16 EFA79052.1 - 0.015 14.9 0.1 0.063 12.9 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DDRGK PF09756.9 EFA79052.1 - 0.051 13.2 1.1 0.088 12.4 0.1 1.9 2 0 0 2 2 2 0 DDRGK domain TPR_7 PF13176.6 EFA79052.1 - 0.095 12.8 0.0 0.4 10.8 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Ribonuc_red_lgC PF02867.15 EFA79053.1 - 3.7e-187 623.0 0.0 5e-187 622.6 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EFA79053.1 - 6.1e-22 77.4 0.0 1.8e-21 75.9 0.0 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EFA79053.1 - 3.6e-15 56.3 0.0 9.8e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain TALPID3 PF15324.6 EFA79053.1 - 0.3 8.7 4.6 0.43 8.2 4.6 1.1 1 0 0 1 1 1 0 Hedgehog signalling target DUF382 PF04037.13 EFA79054.1 - 4.1e-51 172.4 0.6 4.1e-51 172.4 0.6 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 EFA79054.1 - 3.8e-21 74.7 1.0 1.1e-20 73.2 1.0 1.8 1 0 0 1 1 1 1 PSP PX PF00787.24 EFA79055.1 - 2.1e-19 69.6 0.2 2.1e-19 69.6 0.2 3.7 5 0 0 5 5 5 1 PX domain VPS9 PF02204.18 EFA79055.1 - 4e-19 68.8 0.2 4.1e-18 65.5 0.2 2.6 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ras PF00071.22 EFA79055.1 - 1.1e-07 31.6 0.0 2.5e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Ras family DUF5601 PF18151.1 EFA79055.1 - 0.0015 18.8 2.7 0.0063 16.8 1.2 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) DMA PF03474.14 EFA79055.1 - 0.025 14.2 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 DMRTA motif RabGAP-TBC PF00566.18 EFA79056.1 - 2.8e-23 82.7 5.8 6.3e-15 55.4 0.1 6.3 5 1 0 5 5 5 3 Rab-GTPase-TBC domain DUF3439 PF11921.8 EFA79056.1 - 2.5 8.1 24.8 0.79 9.7 10.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) TRAP_beta PF05753.14 EFA79057.1 - 2.5e-42 144.3 0.2 3e-42 144.0 0.2 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) CARDB PF07705.11 EFA79057.1 - 0.012 15.9 0.7 0.035 14.4 0.1 1.9 1 1 1 2 2 2 0 CARDB Ank_5 PF13857.6 EFA79058.1 - 7.6e-16 58.0 4.2 2.7e-08 33.9 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA79058.1 - 4.8e-14 52.1 3.7 2.1e-08 34.3 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFA79058.1 - 1.7e-13 50.8 0.3 1.8e-07 31.6 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79058.1 - 1e-10 42.0 0.1 2.7e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79058.1 - 5.7e-10 38.6 0.6 0.00036 20.7 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat RA PF00788.23 EFA79058.1 - 3.6e-09 37.1 0.0 6.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_f0 PF16511.5 EFA79058.1 - 0.083 13.2 0.3 0.27 11.6 0.2 1.9 2 0 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM Ocnus PF05005.15 EFA79059.1 - 2e-13 50.4 0.0 9.1e-11 41.9 0.0 2.2 1 1 1 2 2 2 2 Janus/Ocnus family (Ocnus) Gcd10p PF04189.13 EFA79060.1 - 2e-48 165.0 1.6 2e-48 165.0 1.6 2.0 2 0 0 2 2 2 1 Gcd10p family Pribosyltran_N PF13793.6 EFA79060.1 - 3.2e-37 127.0 0.3 2.5e-35 120.9 0.0 2.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFA79060.1 - 1.3e-30 106.8 5.5 1.3e-28 100.3 2.4 2.6 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFA79060.1 - 4.9e-12 45.7 4.5 2.7e-11 43.2 0.8 2.9 3 0 0 3 3 3 1 Phosphoribosyl transferase domain TMEM208_SND2 PF05620.11 EFA79061.1 - 5.4e-50 169.5 0.7 6e-50 169.3 0.7 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF2207 PF09972.9 EFA79061.1 - 0.014 14.2 0.3 1.3 7.7 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) ATG27 PF09451.10 EFA79061.1 - 0.036 13.9 0.2 0.054 13.4 0.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 SRF-TF PF00319.18 EFA79061.1 - 0.16 11.4 1.4 0.31 10.6 1.4 1.5 1 0 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) WTF PF03303.13 EFA79061.1 - 2 8.1 5.6 15 5.3 1.9 2.1 2 0 0 2 2 2 0 WTF protein DUF2614 PF11023.8 EFA79061.1 - 2.1 8.4 5.1 3.5 7.7 0.4 2.2 2 0 0 2 2 2 0 Zinc-ribbon containing domain Pkinase PF00069.25 EFA79062.1 - 8.5e-06 25.3 0.1 1.5e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 EFA79063.1 - 3.9e-24 85.4 0.0 5.5e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79063.1 - 0.029 13.6 0.0 0.043 13.1 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase CAP_N PF01213.19 EFA79063.1 - 0.033 13.7 3.7 0.058 12.9 3.7 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ODAM PF15424.6 EFA79063.1 - 0.041 13.5 1.3 1.5 8.4 0.6 2.1 2 0 0 2 2 2 0 Odontogenic ameloblast-associated family Tcp11 PF05794.13 EFA79063.1 - 0.12 11.4 1.0 0.16 11.0 1.0 1.2 1 0 0 1 1 1 0 T-complex protein 11 FAM60A PF15396.6 EFA79063.1 - 0.23 11.4 1.7 1.1 9.2 1.1 1.9 2 0 0 2 2 2 0 Protein Family FAM60A DUF4663 PF15668.5 EFA79063.1 - 0.48 9.4 5.4 0.72 8.9 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) Mito_fiss_reg PF05308.11 EFA79063.1 - 0.8 9.7 7.0 1.2 9.2 7.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator NST1 PF13945.6 EFA79063.1 - 2.6 8.1 7.6 4 7.5 7.6 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Macoilin PF09726.9 EFA79063.1 - 9 4.7 7.1 11 4.4 7.1 1.1 1 0 0 1 1 1 0 Macoilin family DUF3844 PF12955.7 EFA79064.1 - 0.69 10.1 12.2 0.73 10.0 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) Ku PF02735.16 EFA79065.1 - 7.7e-57 192.3 0.0 7.7e-57 192.3 0.0 2.4 3 0 0 3 3 3 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EFA79065.1 - 4.5e-50 170.4 7.8 4.5e-50 170.4 7.8 2.5 2 1 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EFA79065.1 - 8.3e-14 52.1 6.1 8.3e-14 52.1 6.1 3.0 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm zf-CCHH PF10283.9 EFA79065.1 - 9.6e-10 38.3 3.6 1.6e-09 37.6 3.6 1.4 1 0 0 1 1 1 1 PBZ domain HeH PF12949.7 EFA79065.1 - 0.00066 19.3 0.1 0.0015 18.2 0.1 1.6 1 0 0 1 1 1 1 HeH/LEM domain Mucin PF01456.17 EFA79065.1 - 0.094 12.7 11.0 0.28 11.2 11.0 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein AJAP1_PANP_C PF15298.6 EFA79065.1 - 0.82 9.8 7.8 1.9 8.6 7.8 1.6 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF3439 PF11921.8 EFA79065.1 - 1.2 9.2 5.7 3 7.8 5.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4518 PF15008.6 EFA79065.1 - 4.1 6.5 11.0 0.15 11.2 3.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) Mvb12 PF09452.10 EFA79066.1 - 0.072 13.5 0.8 0.14 12.6 0.8 1.5 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 L51_S25_CI-B8 PF05047.16 EFA79067.1 - 1.2e-09 37.9 0.1 2.8e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Glyco_hydro_19 PF00182.19 EFA79068.1 - 1.6e-40 139.4 18.1 2.2e-40 139.0 10.6 4.0 2 1 0 2 2 2 1 Chitinase class I OB_Dis3 PF17849.1 EFA79068.1 - 2e-07 30.9 1.2 22 5.1 0.0 6.1 6 0 0 6 6 6 3 Dis3-like cold-shock domain 2 (CSD2) Tmp39 PF10271.9 EFA79068.1 - 0.00072 18.7 8.4 10 5.0 0.0 5.4 6 0 0 6 6 6 3 Putative transmembrane protein DEC1 PF15859.5 EFA79068.1 - 0.028 14.4 13.3 1.9 8.5 0.1 6.4 7 0 0 7 7 7 0 Deleted in esophageal cancer 1 family SDH_alpha PF03313.15 EFA79068.1 - 0.55 9.9 37.1 8.1 6.0 0.1 6.2 4 2 1 6 6 6 0 Serine dehydratase alpha chain CENP-T_C PF15511.6 EFA79069.1 - 1.1e-07 31.9 0.0 1.6e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EFA79069.1 - 2.3e-05 24.5 0.0 3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EFA79069.1 - 0.0076 16.6 0.0 0.0095 16.3 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EFA79069.1 - 0.013 15.6 0.0 0.015 15.3 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EFA79069.1 - 0.032 14.5 0.0 0.048 13.9 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-18kDa PF02269.16 EFA79069.1 - 0.047 13.7 0.1 0.15 12.1 0.1 1.7 1 1 1 2 2 2 0 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 EFA79069.1 - 0.067 13.6 0.0 0.072 13.4 0.0 1.2 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EFA79069.1 - 0.18 11.8 0.0 0.26 11.3 0.0 1.4 1 1 0 1 1 1 0 Bromodomain associated DDE_3 PF13358.6 EFA79070.1 - 2.8e-22 79.1 0.0 3.1e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 EFA79070.1 - 0.065 13.4 0.0 0.076 13.2 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain Corazonin PF17308.2 EFA79071.1 - 0.0027 18.1 8.2 0.0027 18.1 8.2 2.9 3 0 0 3 3 3 1 Pro-corazonin B277 PF17623.2 EFA79071.1 - 1.9 7.5 5.3 0.26 10.3 1.2 1.7 2 0 0 2 2 2 0 Domain of unknown function Mucin PF01456.17 EFA79073.1 - 0.00061 19.8 16.8 0.00074 19.5 16.8 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.12 EFA79073.1 - 0.007 14.4 7.8 0.0075 14.3 7.8 1.0 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein FERM_f0 PF16511.5 EFA79073.1 - 0.0097 16.2 0.5 0.81 10.0 0.0 2.3 2 1 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM DUF3439 PF11921.8 EFA79073.1 - 0.018 15.0 8.2 0.024 14.6 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Med13_C PF06333.12 EFA79073.1 - 0.026 13.8 5.8 0.028 13.7 5.8 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain SSP160 PF06933.11 EFA79073.1 - 0.037 12.2 15.0 0.043 12.0 15.0 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ORC6 PF05460.13 EFA79073.1 - 0.07 12.4 5.3 0.082 12.2 5.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SAC3 PF12209.8 EFA79073.1 - 0.07 13.3 0.4 0.12 12.6 0.4 1.4 1 0 0 1 1 1 0 Leucine permease transcriptional regulator helical domain NAM-associated PF14303.6 EFA79073.1 - 0.071 13.8 3.4 0.097 13.4 3.4 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain PTRF_SDPR PF15237.6 EFA79073.1 - 0.085 12.5 3.0 0.05 13.2 1.4 1.4 1 1 1 2 2 2 0 PTRF/SDPR family NST1 PF13945.6 EFA79073.1 - 0.088 12.9 1.8 0.1 12.7 1.8 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator AJAP1_PANP_C PF15298.6 EFA79073.1 - 0.089 13.0 10.4 0.11 12.7 10.4 1.1 1 0 0 1 1 1 0 AJAP1/PANP C-terminus ASD2 PF08687.11 EFA79073.1 - 0.22 11.0 3.4 0.29 10.7 3.4 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 FSA_C PF10479.9 EFA79073.1 - 0.34 9.0 9.0 0.38 8.8 9.0 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Tir_receptor_C PF07489.11 EFA79073.1 - 0.42 10.6 11.6 0.51 10.3 11.6 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus p450 PF00067.22 EFA79073.1 - 0.6 8.8 3.7 0.79 8.4 3.7 1.2 1 0 0 1 1 1 0 Cytochrome P450 Sporozoite_P67 PF05642.11 EFA79073.1 - 2.7 6.0 9.1 2.8 5.9 9.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TonB_N PF16031.5 EFA79073.1 - 3.8 8.0 5.7 5 7.6 5.7 1.2 1 0 0 1 1 1 0 TonB polyproline region TMEM154 PF15102.6 EFA79073.1 - 4.5 7.2 11.5 5.7 6.8 11.5 1.2 1 0 0 1 1 1 0 TMEM154 protein family FERM_M PF00373.18 EFA79074.1 - 1.1e-24 87.1 0.8 1.4e-19 70.6 0.0 2.5 2 0 0 2 2 2 2 FERM central domain FERM_N PF09379.10 EFA79074.1 - 2e-06 27.7 0.2 1e-05 25.4 0.0 2.3 3 0 0 3 3 3 1 FERM N-terminal domain EGF_2 PF07974.13 EFA79074.1 - 0.0048 17.2 14.0 0.012 16.0 14.0 1.7 1 0 0 1 1 1 1 EGF-like domain SPECT1 PF18680.1 EFA79074.1 - 0.056 13.1 4.6 0.12 12.0 4.6 1.5 1 0 0 1 1 1 0 Plasmodium host cell traversal SPECT1 EGF PF00008.27 EFA79074.1 - 0.1 12.9 12.1 0.26 11.6 12.1 1.7 1 0 0 1 1 1 0 EGF-like domain Mucin PF01456.17 EFA79074.1 - 0.53 10.3 25.2 1.3 9.0 25.2 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein hEGF PF12661.7 EFA79074.1 - 1 10.1 9.8 3.4 8.5 9.8 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFA79074.1 - 3.1 8.0 8.2 7.4 6.7 8.2 1.7 1 0 0 1 1 1 0 Tenascin EGF domain Gelsolin PF00626.22 EFA79075.1 - 1.8e-49 165.6 1.0 4.4e-12 45.7 0.0 5.6 5 0 0 5 5 5 5 Gelsolin repeat PH PF00169.29 EFA79075.1 - 6.1e-18 65.3 7.9 2.1e-08 34.6 0.1 4.4 4 0 0 4 4 4 3 PH domain VHP PF02209.19 EFA79075.1 - 2.2e-12 46.8 0.3 5.4e-12 45.6 0.3 1.8 1 0 0 1 1 1 1 Villin headpiece domain WD40_4 PF16300.5 EFA79075.1 - 4.2e-12 45.8 0.4 1e-11 44.5 0.4 1.7 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EFA79075.1 - 9.8e-11 42.0 4.1 3e-06 27.8 0.1 4.2 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF1899 PF08953.11 EFA79075.1 - 3.7e-08 33.1 0.1 1.2e-07 31.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) PH_2 PF08458.10 EFA79075.1 - 0.0047 17.3 1.2 1.2 9.6 0.1 2.8 2 0 0 2 2 2 1 Plant pleckstrin homology-like region PH_9 PF15410.6 EFA79075.1 - 0.0051 17.2 1.2 1.3 9.4 0.0 3.1 3 0 0 3 3 3 1 Pleckstrin homology domain PH_11 PF15413.6 EFA79075.1 - 0.0056 17.1 6.2 1.1 9.8 1.1 3.8 2 1 1 3 3 3 2 Pleckstrin homology domain PAC4 PF16093.5 EFA79075.1 - 0.025 14.8 0.1 69 3.7 0.0 4.7 5 0 0 5 5 5 0 Proteasome assembly chaperone 4 Mcp5_PH PF12814.7 EFA79075.1 - 0.14 12.3 2.4 1.3 9.2 0.1 3.0 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology PH_6 PF15406.6 EFA79075.1 - 0.14 12.4 0.7 37 4.7 0.1 3.6 4 0 0 4 4 4 0 Pleckstrin homology domain Atg8 PF02991.16 EFA79076.1 - 5.8e-43 145.3 0.3 6.8e-43 145.1 0.3 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EFA79076.1 - 1.6e-07 31.7 0.0 2e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Phyto_Pns9_10 PF05878.11 EFA79077.1 - 0.0069 15.6 0.6 0.015 14.5 0.5 1.5 2 0 0 2 2 2 1 Phytoreovirus nonstructural protein Pns9/Pns10 BAR_3 PF16746.5 EFA79077.1 - 0.0071 16.1 10.2 0.01 15.5 10.2 1.3 1 0 0 1 1 1 1 BAR domain of APPL family Leg1 PF05612.12 EFA79077.1 - 0.053 12.7 1.2 0.33 10.1 0.2 2.3 2 1 1 3 3 3 0 Leg1 Rsbr_N PF08678.10 EFA79077.1 - 0.062 13.4 3.9 0.15 12.1 2.9 2.2 1 1 1 2 2 2 0 Rsbr N terminal BAR PF03114.18 EFA79077.1 - 0.12 12.0 13.0 0.16 11.6 13.0 1.2 1 0 0 1 1 1 0 BAR domain Noelin-1 PF12308.8 EFA79077.1 - 1.9 8.5 7.0 0.32 11.0 0.5 2.5 2 1 0 2 2 2 0 Neurogenesis glycoprotein TPR_MLP1_2 PF07926.12 EFA79077.1 - 3.4 7.7 11.4 0.27 11.3 0.4 3.0 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Ank_2 PF12796.7 EFA79079.1 - 1.4e-59 198.6 5.9 1.9e-16 60.4 0.0 8.3 6 2 4 10 10 10 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79079.1 - 2.2e-52 174.4 9.5 1.4e-11 44.4 0.0 9.2 7 2 2 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79079.1 - 4.8e-48 161.0 4.4 1.4e-09 38.3 0.0 8.7 3 2 6 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 EFA79079.1 - 2.2e-39 132.2 8.2 1.7e-06 28.2 0.0 10.8 10 0 0 10 10 10 9 Ankyrin repeat Ank_3 PF13606.6 EFA79079.1 - 1.6e-38 126.3 8.5 3.9e-06 26.8 0.1 12.1 11 1 0 11 11 11 7 Ankyrin repeat BTB PF00651.31 EFA79079.1 - 2.5e-20 72.8 0.8 2.9e-19 69.3 0.1 2.7 1 1 1 2 2 2 1 BTB/POZ domain DUF5071 PF16804.5 EFA79079.1 - 0.12 12.6 0.3 3.4 8.0 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5071) Med11 PF10280.9 EFA79080.1 - 2.7e-10 40.8 0.3 3.4e-10 40.5 0.3 1.1 1 0 0 1 1 1 1 Mediator complex protein Pkinase PF00069.25 EFA79081.1 - 4.4e-28 98.4 0.0 1.2e-27 96.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79081.1 - 7.3e-14 51.7 0.0 1.5e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase ANTH PF07651.16 EFA79081.1 - 2.1e-05 23.6 0.1 2.1e-05 23.6 0.1 2.1 2 0 0 2 2 2 1 ANTH domain Kinase-like PF14531.6 EFA79081.1 - 0.00065 19.1 0.1 0.0025 17.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like ENTH PF01417.20 EFA79081.1 - 0.058 13.4 0.3 0.13 12.3 0.3 1.6 1 0 0 1 1 1 0 ENTH domain Pkinase PF00069.25 EFA79082.1 - 1.2e-05 24.9 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain A_amylase_inhib PF01356.19 EFA79083.1 - 0.026 14.5 2.3 0.068 13.2 2.3 1.7 1 0 0 1 1 1 0 Alpha amylase inhibitor TPR_17 PF13431.6 EFA79084.1 - 1.1e-49 163.3 9.4 1.9e-07 31.0 0.0 8.6 8 1 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFA79084.1 - 1.1e-13 50.6 20.6 0.028 14.1 0.4 7.7 8 0 0 8 8 8 7 TPR repeat DUF1153 PF06627.11 EFA79084.1 - 0.0055 16.8 0.5 4.2 7.6 0.0 4.6 7 0 0 7 7 7 1 Protein of unknown function (DUF1153) IMPa_helical PF18642.1 EFA79084.1 - 0.0084 16.5 0.0 0.035 14.5 0.0 2.2 2 0 0 2 2 2 1 Immunomodulating metalloprotease helical domain DUF3085 PF11284.8 EFA79084.1 - 0.021 15.1 0.0 1.2 9.5 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3085) A_amylase_inhib PF01356.19 EFA79085.1 - 0.022 14.8 2.0 0.058 13.4 2.0 1.7 1 0 0 1 1 1 0 Alpha amylase inhibitor SMC_Nse1 PF07574.13 EFA79086.1 - 3.7e-16 59.6 1.9 1.2e-15 57.9 1.9 1.7 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EFA79086.1 - 9.5e-06 25.8 9.9 2.1e-05 24.7 9.9 1.6 1 0 0 1 1 1 1 RING-like domain TackOD1 PF18551.1 EFA79086.1 - 0.013 15.2 9.2 11 5.6 0.0 3.4 2 1 1 3 3 3 0 Thaumarchaeal output domain 1 Zn_ribbon_17 PF17120.5 EFA79086.1 - 0.027 14.1 6.7 0.051 13.2 6.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EFA79086.1 - 0.039 14.3 10.3 0.11 12.9 10.3 1.8 1 0 0 1 1 1 0 Ring finger domain Phage_tail_X PF05489.12 EFA79086.1 - 0.044 13.5 0.1 5.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Phage Tail Protein X C1_1 PF00130.22 EFA79086.1 - 0.56 10.1 10.4 0.13 12.2 4.5 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_4 PF14570.6 EFA79086.1 - 0.99 9.2 8.0 2.5 7.9 8.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Sec23_Sec24 PF04810.15 EFA79086.1 - 4.8 7.3 12.2 2.6 8.2 7.9 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger COPI_assoc PF08507.10 EFA79087.1 - 4.9e-12 46.0 9.5 7e-12 45.5 9.5 1.2 1 0 0 1 1 1 1 COPI associated protein EcsB PF05975.12 EFA79087.1 - 9.3e-05 21.4 1.1 0.00012 21.1 1.1 1.2 1 0 0 1 1 1 1 Bacterial ABC transporter protein EcsB DUF3290 PF11694.8 EFA79087.1 - 0.11 12.5 2.7 2.3 8.2 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) TMEM51 PF15345.6 EFA79087.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 TMEM100 PF16311.5 EFA79087.1 - 0.12 12.0 1.3 0.24 11.0 0.1 1.9 2 0 0 2 2 2 0 Transmembrane protein 100 SPC25 PF06703.11 EFA79087.1 - 2.1 8.1 6.4 8.1 6.2 6.4 1.9 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Phage_holin_3_6 PF07332.11 EFA79087.1 - 3.6 7.6 5.1 12 6.0 5.1 2.0 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III zf-C2HC5 PF06221.13 EFA79088.1 - 0.0092 16.0 0.3 0.024 14.6 0.3 1.6 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type TerY_C PF15616.6 EFA79088.1 - 0.016 15.3 0.3 0.053 13.6 0.3 1.9 1 0 0 1 1 1 0 TerY-C metal binding domain Prok-RING_4 PF14447.6 EFA79088.1 - 0.049 13.5 1.4 0.13 12.1 1.4 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFA79088.1 - 0.087 12.7 0.5 0.17 11.8 0.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA79088.1 - 0.96 9.5 5.4 1.3 9.1 1.3 2.4 2 0 0 2 2 2 0 zinc-RING finger domain PAD_porph PF04371.15 EFA79089.1 - 1e-94 317.4 0.0 1.2e-94 317.2 0.0 1.0 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase DUF1647 PF07801.11 EFA79089.1 - 0.041 13.6 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) Amidinotransf PF02274.17 EFA79089.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Amidinotransferase Cellulase PF00150.18 EFA79090.1 - 1.7e-33 116.2 0.0 3e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SSP160 PF06933.11 EFA79091.1 - 2.8 6.0 21.1 4.4 5.4 21.1 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PUF PF00806.19 EFA79092.1 - 4.6e-55 180.3 7.9 9.1e-08 31.4 0.1 8.8 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat zf_CCCH_4 PF18345.1 EFA79092.1 - 1.1e-05 25.3 6.8 2.4e-05 24.2 6.8 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFA79092.1 - 2e-05 24.3 3.1 4.8e-05 23.1 3.1 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EFA79092.1 - 2.2e-05 24.3 3.8 5.1e-05 23.1 3.8 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFA79092.1 - 0.00012 22.7 1.5 0.00012 22.7 1.5 6.9 5 2 2 7 7 7 1 Torus domain R3H PF01424.22 EFA79093.1 - 0.053 13.5 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 R3H domain Tubulin PF00091.25 EFA79094.1 - 9.4e-65 218.5 0.0 9.4e-65 218.5 0.0 2.2 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFA79094.1 - 7.5e-46 155.4 0.2 1.8e-45 154.1 0.2 1.7 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFA79094.1 - 1.2e-05 25.6 5.5 1.2e-05 25.6 0.0 3.0 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain WD40 PF00400.32 EFA79094.1 - 8.2e-05 23.3 1.3 0.00081 20.2 0.2 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat Tubulin_2 PF13809.6 EFA79094.1 - 0.028 13.6 0.0 0.082 12.1 0.0 1.8 1 0 0 1 1 1 0 Tubulin like ANAPC4_WD40 PF12894.7 EFA79094.1 - 0.043 14.1 1.6 2.3 8.6 0.1 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Secretin_N_2 PF07655.13 EFA79094.1 - 0.19 12.3 7.0 0.19 12.3 4.6 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain DUF1644 PF07800.12 EFA79094.1 - 2.6 8.1 8.3 0.25 11.4 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) TbpB_A PF17484.2 EFA79094.1 - 2.9 8.7 13.6 0.11 13.2 4.1 2.8 2 0 0 2 2 2 0 N-Lobe handle Tf-binding protein B Pkinase PF00069.25 EFA79095.1 - 3.9e-54 183.8 0.0 8.7e-54 182.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79095.1 - 1.2e-27 96.8 0.0 2.2e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I PF08311.12 EFA79095.1 - 1.7e-06 28.0 1.8 8.4e-06 25.8 0.1 2.7 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 FTA2 PF13095.6 EFA79095.1 - 0.0021 17.7 1.9 0.38 10.4 0.0 3.0 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EFA79095.1 - 0.0041 16.7 0.5 0.013 15.1 0.5 1.9 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFA79095.1 - 0.0043 16.4 0.0 0.01 15.1 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFA79095.1 - 0.0095 15.9 0.0 0.039 13.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Mad3_BUB1_I_2 PF17014.5 EFA79095.1 - 0.052 13.7 1.5 0.15 12.2 1.5 1.8 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein ubiquitin PF00240.23 EFA79096.1 - 3e-34 116.6 0.4 3.9e-34 116.2 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EFA79096.1 - 5.5e-28 96.6 13.3 8.3e-28 96.1 13.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EFA79096.1 - 6.1e-16 58.0 0.8 8.8e-16 57.5 0.4 1.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA79096.1 - 3.3e-05 24.2 0.1 0.00013 22.3 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA79096.1 - 0.0049 17.2 0.1 0.0079 16.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA79096.1 - 0.01 15.7 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA79096.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFA79096.1 - 0.021 14.8 0.7 6.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EFA79096.1 - 0.054 14.1 0.1 0.06 13.9 0.1 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Thioredoxin PF00085.20 EFA79097.1 - 1.4e-28 98.9 0.0 8.6e-14 51.4 0.0 3.8 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EFA79097.1 - 3.7e-17 62.8 5.2 1.3e-12 48.1 2.7 3.7 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFA79097.1 - 2e-06 27.9 1.9 0.053 13.7 0.0 3.8 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFA79097.1 - 1.1e-05 25.8 0.5 0.11 12.9 0.1 3.6 3 0 0 3 3 3 2 Thioredoxin-like domain ERp29_N PF07912.13 EFA79097.1 - 9.7e-05 22.5 0.0 3.6 7.7 0.0 3.7 3 0 0 3 3 3 2 ERp29, N-terminal domain Thioredoxin_8 PF13905.6 EFA79097.1 - 0.00044 20.5 0.8 2.8 8.3 0.0 4.1 3 0 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 EFA79097.1 - 0.0032 17.4 0.3 0.16 11.9 0.1 2.8 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EFA79097.1 - 0.012 15.3 0.2 0.21 11.3 0.0 2.7 3 0 0 3 3 3 0 Redoxin NADH_dehy_S2_C PF06444.11 EFA79098.1 - 0.035 14.6 0.6 0.035 14.6 0.6 2.1 2 1 1 3 3 3 0 NADH dehydrogenase subunit 2 C-terminus PQQ_2 PF13360.6 EFA79099.1 - 0.0014 18.3 0.0 0.0041 16.7 0.0 1.8 1 0 0 1 1 1 1 PQQ-like domain WD40 PF00400.32 EFA79099.1 - 0.002 18.9 15.6 2.3 9.2 0.1 7.7 9 0 0 9 9 9 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA79099.1 - 0.0066 16.7 2.9 0.32 11.3 0.0 4.8 4 1 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_16 PF10294.9 EFA79099.1 - 0.02 14.6 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase CPSF_A PF03178.15 EFA79099.1 - 0.027 13.8 0.3 0.092 12.0 0.2 2.0 1 1 0 1 1 1 0 CPSF A subunit region NUP214 PF16755.5 EFA79099.1 - 0.15 11.3 6.1 0.34 10.1 0.1 3.4 2 2 1 4 4 4 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 EBP PF05241.12 EFA79100.1 - 1.8e-17 63.4 0.1 2e-17 63.2 0.1 1.1 1 0 0 1 1 1 1 Emopamil binding protein Paf1 PF03985.13 EFA79101.1 - 4.3e-55 187.4 11.9 4.3e-55 187.4 11.9 2.0 2 0 0 2 2 2 1 Paf1 Macoilin PF09726.9 EFA79101.1 - 0.082 11.5 9.1 0.13 10.8 9.1 1.5 1 0 0 1 1 1 0 Macoilin family EF-hand_7 PF13499.6 EFA79102.1 - 2.4e-05 24.7 0.4 2.4e-05 24.7 0.4 2.1 2 0 0 2 2 2 1 EF-hand domain pair TPR_19 PF14559.6 EFA79102.1 - 3e-05 24.4 0.9 5.3e-05 23.7 0.9 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat EF-hand_6 PF13405.6 EFA79102.1 - 4.8e-05 22.9 0.6 0.00036 20.2 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EFA79102.1 - 9.7e-05 21.7 0.1 0.005 16.3 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 EFA79102.1 - 0.00032 20.1 0.1 0.00074 18.9 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EFA79102.1 - 0.0024 17.7 0.7 0.27 11.1 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF_assoc_1 PF08355.12 EFA79102.1 - 0.039 13.5 0.1 0.092 12.4 0.1 1.6 1 0 0 1 1 1 0 EF hand associated TPR_14 PF13428.6 EFA79102.1 - 0.13 13.1 0.3 14 6.8 0.1 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat NOA36 PF06524.12 EFA79102.1 - 3.1 7.0 13.3 6.3 6.0 13.3 1.5 1 0 0 1 1 1 0 NOA36 protein DAO PF01266.24 EFA79103.1 - 9.2e-44 150.4 0.0 1.1e-43 150.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFA79103.1 - 2.6e-09 36.7 0.0 0.00012 21.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFA79103.1 - 5.5e-09 35.6 0.5 3e-05 23.3 0.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EFA79103.1 - 2.6e-08 33.4 0.2 4.8e-05 22.6 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 EFA79103.1 - 3e-08 32.8 0.3 0.0018 17.0 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 EFA79103.1 - 2e-06 27.9 0.0 5.1e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFA79103.1 - 1.3e-05 24.7 0.4 3.9e-05 23.2 0.4 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFA79103.1 - 3.3e-05 23.2 0.0 7.3e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFA79103.1 - 6.4e-05 22.4 1.2 0.11 11.7 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFA79103.1 - 7.6e-05 22.1 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFA79103.1 - 0.0012 19.4 0.4 0.046 14.3 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 EFA79103.1 - 0.0014 17.2 0.5 0.086 11.3 0.2 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor Amino_oxidase PF01593.24 EFA79103.1 - 0.011 15.0 0.1 0.056 12.7 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase 3HCDH_N PF02737.18 EFA79103.1 - 0.015 15.2 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XTBD PF11952.8 EFA79103.1 - 0.069 12.9 0.0 9.9 6.0 0.0 2.6 2 0 0 2 2 2 0 XRN-Two Binding Domain, XTBD Lycopene_cycl PF05834.12 EFA79103.1 - 0.07 12.2 0.3 0.11 11.5 0.0 1.4 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EFA79103.1 - 0.079 12.9 0.4 8.4 6.4 0.1 2.5 2 1 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EFA79103.1 - 0.1 11.4 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase K_oxygenase PF13434.6 EFA79103.1 - 0.13 11.4 2.7 2.8 7.0 0.7 2.5 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Sugar_tr PF00083.24 EFA79104.1 - 4.5e-79 266.4 34.7 4.5e-79 266.4 34.7 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter CtaG_Cox11 PF04442.14 EFA79104.1 - 1.4e-55 187.5 0.0 1.4e-55 187.5 0.0 1.8 2 0 0 2 2 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 MFS_1 PF07690.16 EFA79104.1 - 3e-32 111.9 28.6 4.2e-28 98.3 26.5 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFA79104.1 - 5.4e-12 45.0 34.4 9.5e-10 37.6 10.6 3.4 2 1 2 4 4 4 2 MFS/sugar transport protein TRI12 PF06609.13 EFA79104.1 - 3.1e-09 35.8 3.0 3.1e-09 35.8 3.0 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EFA79104.1 - 4e-07 29.6 6.0 1.3e-05 24.7 6.4 2.4 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Pex14_N PF04695.13 EFA79104.1 - 0.0027 18.4 5.9 0.0067 17.1 5.9 1.7 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Rick_17kDa_Anti PF05433.15 EFA79104.1 - 0.04 13.8 0.3 0.095 12.6 0.3 1.6 1 0 0 1 1 1 0 Glycine zipper 2TM domain CENP-N PF05238.13 EFA79104.1 - 0.072 12.4 6.0 0.11 11.8 6.0 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like DUF4366 PF14283.6 EFA79104.1 - 0.084 12.9 0.1 0.3 11.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) RIFIN PF02009.16 EFA79104.1 - 0.11 12.3 2.0 0.19 11.6 2.0 1.3 1 0 0 1 1 1 0 Rifin CCDC53 PF10152.9 EFA79104.1 - 0.13 12.7 7.0 0.23 11.9 7.0 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CLN3 PF02487.17 EFA79104.1 - 0.16 11.0 12.6 1.3 8.0 1.7 3.9 3 1 1 4 4 4 0 CLN3 protein RR_TM4-6 PF06459.12 EFA79104.1 - 0.19 11.5 7.0 0.33 10.7 7.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 EFA79104.1 - 0.21 11.6 5.0 0.98 9.4 1.5 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EVI2A PF05399.11 EFA79104.1 - 0.93 9.0 6.0 0.5 9.9 3.6 1.9 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Connexin PF00029.19 EFA79104.1 - 1.2 8.9 3.6 1.2 8.9 1.0 2.3 3 0 0 3 3 3 0 Connexin Herpes_LMP1 PF05297.11 EFA79104.1 - 3.2 6.8 5.7 6.2 5.9 5.7 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RAMP4 PF06624.12 EFA79104.1 - 3.7 7.7 6.7 0.24 11.5 0.4 2.2 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 CobT PF06213.12 EFA79104.1 - 8.5 5.7 14.7 14 5.0 14.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT UPF0121 PF03661.13 EFA79105.1 - 6.7e-26 91.2 14.9 8.9e-26 90.7 14.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Pex14_N PF04695.13 EFA79105.1 - 0.004 17.8 6.2 0.0076 16.9 6.2 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CDK2AP PF09806.9 EFA79105.1 - 0.02 15.0 1.7 0.028 14.5 1.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DAG_kinase_N PF14513.6 EFA79105.1 - 0.02 15.1 1.0 0.03 14.5 1.0 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus DUF913 PF06025.12 EFA79105.1 - 0.045 12.7 1.3 0.49 9.3 0.2 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) NAM-associated PF14303.6 EFA79105.1 - 0.29 11.9 5.7 0.44 11.2 5.7 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF5336 PF17270.2 EFA79105.1 - 0.63 9.6 4.0 0.25 11.0 0.9 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5336) GET2 PF08690.10 EFA79105.1 - 1.9 8.1 7.3 0.11 12.1 1.5 1.8 2 0 0 2 2 2 0 GET complex subunit GET2 Retinal PF15449.6 EFA79105.1 - 4.5 4.9 11.3 5.9 4.5 11.3 1.0 1 0 0 1 1 1 0 Retinal protein Proteasome PF00227.26 EFA79106.1 - 4.7e-58 195.8 0.6 6.7e-58 195.3 0.6 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA79106.1 - 4.6e-14 51.8 0.1 8.3e-14 50.9 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GTP_EFTU PF00009.27 EFA79107.1 - 1.5e-58 197.6 0.0 2.3e-58 197.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFA79107.1 - 1.3e-23 83.1 0.0 4e-23 81.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EFA79107.1 - 5.9e-20 71.1 0.0 2.4e-19 69.2 0.0 2.1 1 1 1 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFA79107.1 - 2.3e-13 50.3 0.0 5.4e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFA79107.1 - 3.8e-11 42.9 0.0 8.4e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 EFA79107.1 - 0.00012 21.9 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain tRNA_NucTran2_2 PF13735.6 EFA79107.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative zf-RING_2 PF13639.6 EFA79109.1 - 3.8e-11 43.1 7.6 6.8e-11 42.3 7.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFA79109.1 - 1.1e-08 34.7 8.8 2.5e-08 33.5 8.8 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EFA79109.1 - 1.7e-07 31.4 5.7 1.7e-07 31.4 5.7 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFA79109.1 - 9.9e-06 25.3 7.7 1.9e-05 24.4 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA79109.1 - 9.1e-05 22.2 8.1 0.00021 21.1 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA79109.1 - 0.00058 19.8 7.1 0.0013 18.7 7.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA79109.1 - 0.00072 19.5 5.4 0.0013 18.6 5.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFA79109.1 - 0.0015 18.3 5.3 0.0024 17.7 5.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFA79109.1 - 0.0075 16.3 1.6 0.019 15.0 1.6 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFA79109.1 - 0.019 14.6 5.5 0.035 13.7 5.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EFA79109.1 - 0.93 9.4 6.2 1.9 8.4 6.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FNIP PF05725.12 EFA79110.1 - 4e-87 286.1 49.7 5.1e-16 58.6 2.9 11.4 8 2 3 11 11 11 9 FNIP Repeat DUF1769 PF08588.10 EFA79110.1 - 3.3e-06 27.2 5.6 9.9 6.5 0.0 7.2 4 3 2 7 7 7 3 Protein of unknown function (DUF1769) F-box_5 PF18511.1 EFA79110.1 - 0.035 13.7 0.1 0.061 12.9 0.1 1.4 1 0 0 1 1 1 0 F-box Phage_min_tail PF05939.13 EFA79110.1 - 0.036 14.5 0.0 35 4.8 0.0 4.1 4 1 0 4 4 4 0 Phage minor tail protein Pkinase PF00069.25 EFA79111.1 - 2.7e-25 89.3 0.0 5.9e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DSPc PF00782.20 EFA79111.1 - 1.3e-23 83.3 0.0 1.3e-23 83.3 0.0 2.8 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Pkinase_Tyr PF07714.17 EFA79111.1 - 6.5e-14 51.8 0.0 1.3e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Rad51 PF08423.11 EFA79112.1 - 3.3e-21 75.7 0.1 4.1e-21 75.4 0.1 1.1 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 EFA79112.1 - 5.9e-09 35.6 1.3 6.1e-09 35.6 0.3 1.5 2 0 0 2 2 2 1 KaiC RecA PF00154.21 EFA79112.1 - 1.8e-05 24.3 0.2 0.00016 21.2 0.0 2.2 1 1 1 3 3 3 1 recA bacterial DNA recombination protein CobU PF02283.16 EFA79112.1 - 0.00011 21.9 0.0 0.0022 17.6 0.0 2.2 1 1 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase DnaB_C PF03796.15 EFA79112.1 - 0.0006 19.2 0.6 0.0041 16.5 0.1 2.5 2 1 0 2 2 2 1 DnaB-like helicase C terminal domain Hydrolase_6 PF13344.6 EFA79112.1 - 0.00069 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 EFA79112.1 - 0.0012 19.3 0.0 0.0028 18.2 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EFA79112.1 - 0.01 16.1 0.1 0.038 14.3 0.0 2.0 2 1 0 2 2 2 0 AAA domain DnaA_N PF11638.8 EFA79112.1 - 0.02 14.6 0.0 0.44 10.3 0.0 2.6 2 0 0 2 2 2 0 DnaA N-terminal domain AAA_25 PF13481.6 EFA79112.1 - 0.029 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFA79112.1 - 0.12 12.1 0.4 0.29 10.8 0.4 1.6 1 1 0 1 1 1 0 AAA domain RNA_pol_Rpb2_6 PF00562.28 EFA79113.1 - 3.2e-124 415.0 3.2 6.9e-122 407.3 0.3 2.7 3 0 0 3 3 3 2 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFA79113.1 - 1.3e-69 233.8 0.2 2.5e-69 232.9 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EFA79113.1 - 4.5e-49 166.7 0.0 8.9e-49 165.7 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EFA79113.1 - 4.8e-29 100.6 7.0 4.4e-25 87.9 0.2 3.2 3 0 0 3 3 2 2 RNA polymerase Rpb2, domain 7 Intein_splicing PF14890.6 EFA79113.1 - 2.1e-24 86.0 0.0 9.5e-13 48.3 0.0 2.8 2 1 0 2 2 2 2 Intein splicing domain RNA_pol_Rpb2_4 PF04566.13 EFA79113.1 - 1.8e-23 82.6 1.2 1.2e-22 80.0 0.3 2.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EFA79113.1 - 1.3e-18 67.3 3.4 3.7e-18 65.8 3.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Hint PF01079.20 EFA79113.1 - 2e-06 27.5 0.1 5.2e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 Hint module RNA_pol_Rpb2_3 PF04565.16 EFA79113.1 - 4.5e-06 26.7 0.9 0.024 14.8 0.0 2.7 1 1 1 2 2 2 2 RNA polymerase Rpb2, domain 3 PT-HINT PF07591.11 EFA79113.1 - 0.001 19.3 0.1 0.0037 17.5 0.1 1.9 2 0 0 2 2 2 1 Pretoxin HINT domain LAGLIDADG_3 PF14528.6 EFA79113.1 - 0.0014 18.9 0.2 0.0062 16.8 0.0 2.3 2 0 0 2 2 2 1 LAGLIDADG-like domain Hom_end_hint PF05203.16 EFA79113.1 - 0.017 15.1 0.0 0.038 14.0 0.0 1.6 1 0 0 1 1 1 0 Hom_end-associated Hint zf-B_box PF00643.24 EFA79114.1 - 1.7e-06 28.1 4.0 1.7e-06 28.1 4.0 2.6 2 0 0 2 2 2 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EFA79114.1 - 0.0011 18.8 3.4 0.0011 18.8 3.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DHODB_Fe-S_bind PF10418.9 EFA79114.1 - 0.027 14.3 1.6 0.1 12.4 1.6 2.0 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B BAR_3 PF16746.5 EFA79114.1 - 0.043 13.5 2.3 0.098 12.3 2.3 1.6 1 0 0 1 1 1 0 BAR domain of APPL family Dicty_CAR PF05462.11 EFA79115.1 - 2.5e-10 40.0 7.9 3.9e-10 39.3 7.9 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EFA79115.1 - 0.00015 21.2 4.0 0.00022 20.6 4.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPR_Gpa2_C PF11970.8 EFA79115.1 - 0.00017 21.5 0.2 0.00045 20.2 0.2 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Frizzled PF01534.17 EFA79115.1 - 0.0061 15.7 5.6 0.013 14.5 5.5 1.5 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Vpu PF00558.19 EFA79115.1 - 0.46 10.3 3.9 0.82 9.5 0.3 2.3 2 0 0 2 2 2 0 Vpu protein DUF1681 PF07933.14 EFA79116.1 - 9.5e-48 161.7 0.2 3.1e-47 160.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1681) LRR_6 PF13516.6 EFA79116.1 - 3.5e-05 23.5 8.8 0.23 11.6 0.4 5.2 5 0 0 5 5 5 2 Leucine Rich repeat TMEM51 PF15345.6 EFA79116.1 - 0.11 12.3 4.1 2.5 7.9 0.1 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 DUF87 PF01935.17 EFA79116.1 - 0.67 10.0 5.3 3.4 7.7 0.1 2.3 1 1 1 2 2 2 0 Helicase HerA, central domain TFIIA PF03153.13 EFA79116.1 - 1.5 8.7 31.3 2.5 8.0 7.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Menin PF05053.13 EFA79116.1 - 2.2 6.5 7.2 4.3 5.6 7.2 1.4 1 0 0 1 1 1 0 Menin Rap_GAP PF02145.15 EFA79117.1 - 8.5e-43 146.1 1.9 8.5e-43 146.1 1.9 2.4 2 0 0 2 2 2 1 Rap/ran-GAP DUF2935 PF11155.8 EFA79117.1 - 3.4 8.0 10.4 27 5.1 1.2 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Glyco_transf_41 PF13844.6 EFA79117.1 - 9.6 4.5 9.9 0.48 8.8 3.7 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 41 Abhydrolase_1 PF00561.20 EFA79118.1 - 2.6e-18 66.6 0.0 9e-18 64.8 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA79118.1 - 4.6e-12 47.0 0.0 5.9e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA79118.1 - 3.6e-11 42.8 0.0 1.2e-10 41.1 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 EFA79118.1 - 0.0004 20.1 1.2 0.033 13.8 0.1 2.5 2 1 1 3 3 3 2 Serine hydrolase (FSH1) DUF2048 PF09752.9 EFA79118.1 - 0.0097 15.0 0.7 1.2 8.2 0.3 2.4 2 1 0 2 2 2 2 Abhydrolase domain containing 18 Thioesterase PF00975.20 EFA79118.1 - 0.033 14.3 0.1 0.46 10.6 0.1 2.2 2 0 0 2 2 2 0 Thioesterase domain Esterase PF00756.20 EFA79118.1 - 0.21 11.2 0.4 0.49 10.0 0.4 1.5 1 0 0 1 1 1 0 Putative esterase Pkinase PF00069.25 EFA79119.1 - 9.1e-68 228.5 0.2 1.3e-66 224.7 0.2 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79119.1 - 2.1e-38 132.1 0.1 3.7e-37 128.0 0.1 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EFA79119.1 - 3.1e-16 58.9 0.0 6.2e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EFA79119.1 - 5.1e-08 32.6 0.0 4.2e-07 29.6 0.0 2.5 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFA79119.1 - 0.00032 20.1 0.5 0.00076 18.9 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA79119.1 - 0.022 14.7 3.2 0.14 12.1 0.1 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFA79119.1 - 3.3 6.5 17.9 0.048 12.6 0.3 3.1 2 1 1 3 3 3 0 Haspin like kinase domain CBM9_2 PF16011.5 EFA79121.1 - 3.3e-05 23.7 1.2 8.6e-05 22.3 1.2 1.6 1 1 0 1 1 1 1 Carbohydrate-binding family 9 CBM9_1 PF06452.11 EFA79121.1 - 0.0045 16.9 0.0 0.0095 15.9 0.0 1.6 1 1 0 1 1 1 1 Carbohydrate family 9 binding domain-like Ncstrn_small PF18266.1 EFA79122.1 - 9e-32 110.4 0.0 2.2e-31 109.1 0.0 1.7 1 0 0 1 1 1 1 Nicastrin small lobe Nicastrin PF05450.15 EFA79122.1 - 3.7e-31 108.4 0.2 7.6e-31 107.4 0.2 1.5 1 0 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.17 EFA79122.1 - 0.00095 18.9 0.4 0.0017 18.0 0.4 1.5 1 1 0 1 1 1 1 Peptidase family M28 EXS PF03124.14 EFA79124.1 - 2.3e-72 244.1 29.4 5.3e-66 223.2 23.9 2.2 1 1 1 2 2 2 2 EXS family SPX PF03105.19 EFA79124.1 - 2.2e-42 146.4 36.5 2.2e-42 146.4 36.5 2.3 2 0 0 2 2 2 1 SPX domain SUIM_assoc PF16619.5 EFA79124.1 - 0.0011 18.9 19.2 0.023 14.8 2.5 3.9 3 0 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 ACPS PF01648.20 EFA79125.1 - 1.5e-17 63.8 0.0 4.3e-16 59.1 0.0 2.2 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase superfamily BTB PF00651.31 EFA79126.1 - 5.3e-14 52.4 0.1 2.4e-06 27.8 0.1 2.8 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 EFA79126.1 - 1.3e-08 34.8 1.8 5e-05 23.3 0.0 3.9 3 1 1 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.8 EFA79126.1 - 0.076 13.2 0.3 0.88 9.8 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) RRM_3 PF08777.11 EFA79127.1 - 6.2e-25 87.2 10.0 1.2e-24 86.2 1.3 2.8 2 1 1 3 3 3 2 RNA binding motif La PF05383.17 EFA79127.1 - 4.6e-22 77.8 0.1 1.2e-21 76.5 0.1 1.8 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFA79127.1 - 4.5e-18 64.8 0.2 3.3e-08 33.2 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Caldesmon PF02029.15 EFA79127.1 - 0.022 13.6 10.1 0.032 13.0 10.1 1.2 1 0 0 1 1 1 0 Caldesmon DUF1773 PF08593.10 EFA79127.1 - 0.063 14.3 0.1 0.21 12.7 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function Podoplanin PF05808.11 EFA79128.1 - 0.5 10.5 3.9 0.48 10.5 3.9 1.1 1 0 0 1 1 1 0 Podoplanin Ion_trans PF00520.31 EFA79130.1 - 6.6e-07 28.8 11.2 1e-06 28.1 11.2 1.3 1 0 0 1 1 1 1 Ion transport protein CBM49 PF09478.10 EFA79132.1 - 1e-14 54.6 0.2 1.9e-14 53.7 0.2 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Med26 PF08711.11 EFA79133.1 - 4.1e-05 23.5 0.1 0.00011 22.1 0.1 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain CDC45 PF02724.14 EFA79134.1 - 7.4 4.7 11.4 1.2 7.4 6.2 2.0 2 0 0 2 2 2 0 CDC45-like protein Sulfate_transp PF00916.20 EFA79135.1 - 2e-103 346.1 18.7 2e-103 346.1 18.7 1.4 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 EFA79135.1 - 1.4e-23 82.8 0.1 2.9e-23 81.7 0.1 1.6 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EFA79135.1 - 2.1e-05 24.8 0.0 3.6e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 STAS domain Condensin2nSMC PF12422.8 EFA79135.1 - 0.07 13.3 0.2 0.14 12.3 0.2 1.4 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit ID PF18543.1 EFA79135.1 - 0.096 12.7 0.0 0.31 11.1 0.0 1.9 1 0 0 1 1 1 0 Intracellular delivery domain N2227 PF07942.12 EFA79136.1 - 3.6e-55 187.1 8.5 1.3e-43 149.2 1.3 2.7 2 1 1 3 3 3 2 N2227-like protein Methyltransf_12 PF08242.12 EFA79136.1 - 0.011 16.5 0.0 0.3 11.9 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFA79136.1 - 0.058 14.0 0.0 0.25 12.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain MSP7_C PF12948.7 EFA79136.1 - 0.32 11.7 8.9 0.2 12.3 5.6 2.2 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain Malate_synthase PF01274.22 EFA79137.1 - 2.3e-202 673.0 0.0 2.5e-202 672.8 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Peptidase_C1_2 PF03051.15 EFA79137.1 - 0.002 17.0 0.0 0.003 16.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase C1-like family adh_short PF00106.25 EFA79138.1 - 1.6e-55 187.6 0.2 2.6e-55 186.9 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA79138.1 - 1.5e-40 139.2 0.1 1.8e-40 138.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA79138.1 - 2.1e-14 53.8 0.0 3.1e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFA79138.1 - 0.0013 18.0 0.6 0.003 16.8 0.6 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_Gly3P_dh_N PF01210.23 EFA79138.1 - 0.048 13.6 0.1 0.11 12.4 0.1 1.7 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SHS2_Rpb7-N PF03876.17 EFA79139.1 - 5e-13 49.2 0.1 1.6e-12 47.6 0.1 1.9 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EFA79139.1 - 7.1e-11 42.3 0.0 1.6e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Hepsin-SRCR PF09272.10 EFA79139.1 - 0.024 15.2 1.2 1.1 9.9 0.1 3.4 3 0 0 3 3 3 0 Hepsin, SRCR domain RNA_pol_Rbc25 PF08292.12 EFA79139.1 - 0.14 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Lipase_3 PF01764.25 EFA79140.1 - 0.01 15.7 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) DUF5600 PF18150.1 EFA79140.1 - 0.011 16.3 1.0 0.08 13.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5600) Gam PF06064.11 EFA79141.1 - 0.0076 16.5 0.3 0.58 10.4 0.0 3.6 4 1 0 4 4 4 1 Host-nuclease inhibitor protein Gam F-box-like PF12937.7 EFA79141.1 - 0.07 13.0 0.0 0.37 10.7 0.0 2.3 1 0 0 1 1 1 0 F-box-like LRR_6 PF13516.6 EFA79141.1 - 1.7 8.9 18.1 7.7 6.9 0.2 5.8 6 0 0 6 6 6 0 Leucine Rich repeat AMP-binding PF00501.28 EFA79142.1 - 7.5e-21 74.2 0.0 1.7e-20 73.0 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme zf-HIT PF04438.16 EFA79143.1 - 3.2e-07 30.1 11.6 5.3e-07 29.4 11.6 1.4 1 0 0 1 1 1 1 HIT zinc finger DUF4471 PF14740.6 EFA79143.1 - 0.0058 15.9 0.7 0.0063 15.8 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) Cwf_Cwc_15 PF04889.12 EFA79143.1 - 0.039 13.7 12.5 0.05 13.3 12.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3391 PF11871.8 EFA79143.1 - 0.073 13.6 1.8 0.094 13.3 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) BLACT_WH PF17778.1 EFA79143.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain RPN2_C PF18004.1 EFA79143.1 - 0.23 11.4 6.3 0.36 10.7 6.3 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain OPA3 PF07047.12 EFA79144.1 - 5.9e-22 77.8 4.9 1e-13 51.1 0.7 2.1 1 1 1 2 2 2 2 Optic atrophy 3 protein (OPA3) TssO PF17561.2 EFA79144.1 - 0.0089 16.1 0.4 0.011 15.8 0.4 1.2 1 0 0 1 1 1 1 Type VI secretion system, TssO Atg14 PF10186.9 EFA79144.1 - 0.0098 15.0 0.8 0.011 14.9 0.8 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 EFA79144.1 - 0.023 15.1 0.8 0.037 14.5 0.4 1.6 1 1 0 1 1 1 0 Cell division protein ZapB DUF2205 PF10224.9 EFA79144.1 - 0.07 13.1 1.7 0.11 12.5 1.7 1.3 1 0 0 1 1 1 0 Short coiled-coil protein DUF4140 PF13600.6 EFA79144.1 - 0.11 12.9 0.3 0.17 12.3 0.3 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CDP-OH_P_transf PF01066.21 EFA79145.1 - 3.2e-17 63.0 0.4 3.2e-17 63.0 0.4 3.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase RabGAP-TBC PF00566.18 EFA79146.1 - 5e-41 140.7 1.3 4.1e-24 85.4 0.0 2.5 1 1 1 2 2 2 2 Rab-GTPase-TBC domain LIFR_N PF18207.1 EFA79146.1 - 0.0099 16.2 1.4 0.04 14.3 1.4 2.0 1 0 0 1 1 1 1 Leukemia inhibitory factor receptor N-terminal domain Staufen_C PF16482.5 EFA79146.1 - 0.031 14.4 0.2 0.031 14.4 0.2 1.9 2 0 0 2 2 2 0 Staufen C-terminal domain IMUP PF15761.5 EFA79146.1 - 0.83 10.4 7.6 5.3 7.8 4.4 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein SMC_N PF02463.19 EFA79147.1 - 1.3e-36 126.1 56.9 1.4e-22 80.3 1.1 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFA79147.1 - 5.8e-27 94.3 0.8 5.7e-26 91.1 0.1 3.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EFA79147.1 - 3.6e-12 46.7 20.0 3.6e-12 46.7 20.0 4.5 2 2 1 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 EFA79147.1 - 4.7e-10 39.8 20.4 8.7e-07 29.0 0.4 4.1 2 2 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA79147.1 - 1.7e-06 27.7 0.4 5.1e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF1664 PF07889.12 EFA79147.1 - 2.4e-05 24.4 53.3 4.8e-05 23.4 7.3 7.7 5 3 2 7 7 7 2 Protein of unknown function (DUF1664) AAA_23 PF13476.6 EFA79147.1 - 3.7e-05 24.3 38.9 3.7e-05 24.3 38.9 6.8 2 2 2 5 5 5 1 AAA domain ABC_tran PF00005.27 EFA79147.1 - 0.0062 17.0 0.0 0.0062 17.0 0.0 5.5 4 2 0 4 4 4 2 ABC transporter AAA_22 PF13401.6 EFA79147.1 - 0.0079 16.5 3.8 5.7 7.2 0.0 4.2 4 0 0 4 4 4 2 AAA domain SbcCD_C PF13558.6 EFA79147.1 - 0.026 14.7 0.0 0.08 13.2 0.0 1.9 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Dicty_spore_N PF04562.12 EFA79148.1 - 1.3e-51 174.1 57.2 2.2e-30 105.7 22.8 5.8 3 1 3 6 6 6 2 Dictyostelium spore coat protein, N terminus FOLN PF09289.10 EFA79148.1 - 0.00011 22.3 13.1 0.0013 18.9 1.9 8.6 8 0 0 8 8 8 4 Follistatin/Osteonectin-like EGF domain TILa PF12714.7 EFA79148.1 - 0.0043 17.0 11.5 0.0064 16.4 3.1 11.6 11 2 0 11 11 11 7 TILa domain Gelsolin PF00626.22 EFA79149.1 - 1.3e-62 207.6 9.9 1.5e-14 53.6 0.0 8.6 8 0 0 8 8 8 7 Gelsolin repeat LRR_8 PF13855.6 EFA79149.1 - 8.9e-25 86.2 41.9 2.7e-09 36.7 4.2 4.9 1 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFA79149.1 - 3.4e-18 65.4 46.2 8.5e-05 22.9 6.1 5.7 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFA79149.1 - 5.5e-05 22.7 22.3 0.037 13.5 3.1 3.9 1 1 3 4 4 4 4 Leucine-rich repeat DUF4887 PF16228.5 EFA79149.1 - 0.00079 19.6 24.6 0.00079 19.6 24.6 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4887) LRR_1 PF00560.33 EFA79149.1 - 0.0024 18.1 31.0 13 6.8 0.2 9.1 9 1 1 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.6 EFA79149.1 - 1 9.6 34.6 2.1 8.6 0.2 8.2 9 0 0 9 9 9 0 Leucine Rich repeat His_Phos_2 PF00328.22 EFA79150.1 - 4.7e-22 78.9 2.7 7.9e-21 74.8 1.7 2.6 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 2) FNIP PF05725.12 EFA79151.1 - 7.6e-39 131.6 33.1 1.8e-10 40.8 0.4 7.2 6 1 1 7 7 7 6 FNIP Repeat GATA PF00320.27 EFA79151.1 - 2.4e-06 27.0 2.5 4.8e-06 26.1 2.5 1.5 1 0 0 1 1 1 1 GATA zinc finger PBP1_TM PF14812.6 EFA79151.1 - 0.17 12.3 0.1 0.17 12.3 0.1 1.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AT_hook PF02178.19 EFA79151.1 - 1.7 8.7 6.6 4 7.6 6.6 1.6 1 0 0 1 1 1 0 AT hook motif Sacchrp_dh_C PF16653.5 EFA79152.1 - 1.1e-78 265.0 0.0 2.5e-78 263.8 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.15 EFA79152.1 - 2.3e-27 96.0 0.0 1.7e-26 93.1 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.18 EFA79152.1 - 2.6e-17 63.3 0.0 5e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EFA79152.1 - 3.2e-09 36.4 0.0 7.5e-06 25.4 0.0 3.2 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain GFO_IDH_MocA PF01408.22 EFA79152.1 - 0.025 15.4 0.0 0.053 14.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_10 PF13460.6 EFA79152.1 - 0.063 13.2 0.2 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 NAD(P)H-binding Shikimate_DH PF01488.20 EFA79152.1 - 0.095 12.8 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Snf7 PF03357.21 EFA79153.1 - 6.1e-29 100.8 23.2 7.4e-29 100.5 23.2 1.2 1 0 0 1 1 1 1 Snf7 DUF4365 PF14280.6 EFA79153.1 - 0.004 17.1 0.1 0.0056 16.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4365) DUF1110 PF06533.12 EFA79153.1 - 0.047 13.6 4.3 0.063 13.2 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) SKG6 PF08693.10 EFA79154.1 - 1.2e-05 24.6 0.6 2.5e-05 23.6 0.6 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Glyco_transf_10 PF00852.19 EFA79155.1 - 1.7e-32 112.6 3.9 3.6e-32 111.5 3.9 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Laminin_G_3 PF13385.6 EFA79155.1 - 1.9e-13 50.9 0.0 3.3e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_tran_10_N PF17039.5 EFA79155.1 - 0.00031 21.2 0.9 0.0016 18.9 0.0 2.6 3 0 0 3 3 3 1 Fucosyltransferase, N-terminal ODR4-like PF14778.6 EFA79156.1 - 4.3e-72 243.1 6.6 4.3e-72 243.1 6.6 1.9 1 1 1 2 2 2 1 Olfactory receptor 4-like Mucin PF01456.17 EFA79156.1 - 0.37 10.8 17.0 0.75 9.8 17.0 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein YscJ_FliF_C PF08345.11 EFA79156.1 - 0.89 9.9 9.4 2.1 8.6 9.4 1.6 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal DUF3439 PF11921.8 EFA79156.1 - 3.8 7.5 13.5 9.3 6.2 13.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TMEM154 PF15102.6 EFA79156.1 - 6.2 6.7 12.4 20 5.1 12.2 2.0 1 1 0 1 1 1 0 TMEM154 protein family UCR_6-4kD PF08997.10 EFA79157.1 - 2.4e-09 37.0 0.3 2.8e-09 36.8 0.3 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein QCR10 PF09796.9 EFA79157.1 - 0.0077 16.3 0.9 0.016 15.3 0.9 1.5 1 1 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) PBD PF00786.28 EFA79158.1 - 3.9e-05 23.9 0.0 3.9e-05 23.9 0.0 3.5 3 0 0 3 3 3 1 P21-Rho-binding domain FlaC_arch PF05377.11 EFA79158.1 - 0.015 15.7 4.6 0.015 15.7 4.6 8.5 8 1 0 8 8 8 0 Flagella accessory protein C (FlaC) PKcGMP_CC PF16808.5 EFA79158.1 - 0.03 14.2 0.8 0.03 14.2 0.8 5.8 5 1 1 6 6 6 0 Coiled-coil N-terminus of cGMP-dependent protein kinase WH2 PF02205.20 EFA79158.1 - 0.033 14.0 0.0 0.12 12.2 0.0 2.1 1 0 0 1 1 1 0 WH2 motif HOOK PF05622.12 EFA79158.1 - 9.9 4.2 104.7 5.8 4.9 39.4 2.7 1 1 2 3 3 3 0 HOOK protein Atg14 PF10186.9 EFA79160.1 - 5.4e-17 61.9 10.4 1.8e-16 60.1 10.4 1.7 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EFA79160.1 - 6.1e-05 22.1 7.5 0.00022 20.3 7.5 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting 38 HNH_4 PF13395.6 EFA79160.1 - 0.2 11.6 0.2 0.2 11.6 0.2 2.0 2 0 0 2 2 2 0 HNH endonuclease HalX PF08663.10 EFA79160.1 - 8.5 6.8 9.5 0.47 10.8 1.7 2.6 3 0 0 3 3 3 0 HalX domain MRP-L47 PF06984.13 EFA79161.1 - 1.4e-21 76.4 1.6 1.6e-21 76.2 0.4 1.7 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 EFA79161.1 - 4.1e-09 36.3 1.6 9.3e-09 35.1 1.6 1.6 1 0 0 1 1 1 1 Ribosomal L29 protein DUF3106 PF11304.8 EFA79161.1 - 0.091 13.2 0.3 0.17 12.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) FNIP PF05725.12 EFA79164.1 - 2e-12 47.0 20.8 0.0037 17.4 0.3 8.5 5 2 4 9 9 9 7 FNIP Repeat F-box-like PF12937.7 EFA79164.1 - 0.0065 16.3 0.0 0.023 14.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA79164.1 - 0.0082 16.0 0.2 0.034 14.0 0.2 2.1 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EFA79164.1 - 0.067 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 F-box F-box_5 PF18511.1 EFA79165.1 - 4.2e-05 23.0 0.0 6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA79165.1 - 0.00013 21.8 0.0 0.00017 21.4 0.0 1.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA79165.1 - 0.0012 18.7 0.3 0.0017 18.2 0.3 1.2 1 0 0 1 1 1 1 F-box domain AAA_11 PF13086.6 EFA79166.1 - 2.1e-16 60.5 3.0 1.5e-08 34.7 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_12 PF13087.6 EFA79166.1 - 3.8e-16 59.3 1.1 9.3e-16 58.0 1.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA79166.1 - 1.3e-14 54.3 0.0 3.8e-14 52.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFA79166.1 - 2.6e-13 50.5 0.0 5.5e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFA79166.1 - 4e-08 33.3 0.0 0.0015 18.3 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EFA79166.1 - 0.00019 21.3 0.1 0.00068 19.5 0.0 2.0 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 EFA79166.1 - 0.00071 19.3 0.0 0.0068 16.2 0.0 2.5 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain PhoH PF02562.16 EFA79166.1 - 0.0025 17.3 0.0 0.029 13.8 0.0 2.2 1 1 0 1 1 1 1 PhoH-like protein DEAD PF00270.29 EFA79166.1 - 0.0055 16.5 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA79166.1 - 0.0063 16.8 0.0 0.021 15.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain RAMA PF18755.1 EFA79166.1 - 0.071 13.5 0.0 0.4 11.1 0.0 2.3 3 0 0 3 3 3 0 Restriction Enzyme Adenine Methylase Associated DUF2362 PF10154.9 EFA79167.1 - 1.2e-67 229.0 33.7 8.1e-33 114.1 14.2 3.5 2 1 1 3 3 3 3 Uncharacterized conserved protein (DUF2362) Ribosomal_S9 PF00380.19 EFA79170.1 - 1.3e-31 109.6 0.2 1.5e-31 109.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 AMP-binding PF00501.28 EFA79172.1 - 6.7e-56 189.7 0.0 1e-55 189.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA79172.1 - 0.0012 19.7 0.0 0.003 18.5 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain S-antigen PF05756.11 EFA79172.1 - 0.023 15.0 2.9 0.058 13.8 2.9 1.7 1 0 0 1 1 1 0 S-antigen protein Siva PF05458.12 EFA79172.1 - 0.17 11.5 1.4 0.34 10.6 1.4 1.4 1 0 0 1 1 1 0 Cd27 binding protein (Siva) PBP1_TM PF14812.6 EFA79172.1 - 3.6 8.0 6.9 7.8 7.0 6.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cullin PF00888.22 EFA79173.1 - 3.4e-224 746.1 27.9 5.2e-224 745.4 27.9 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFA79173.1 - 8.5e-29 99.4 4.8 4.1e-28 97.2 4.8 2.3 1 0 0 1 1 1 1 Cullin protein neddylation domain HTH_24 PF13412.6 EFA79173.1 - 0.067 12.8 0.4 0.39 10.3 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 EFA79173.1 - 0.073 12.9 0.0 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain Penicillinase_R PF03965.16 EFA79173.1 - 0.64 10.4 4.9 0.54 10.6 0.2 3.2 3 1 1 4 4 4 0 Penicillinase repressor Glyco_hydro_4C PF11975.8 EFA79173.1 - 5.7 6.9 7.2 12 5.9 0.3 3.2 3 1 0 3 3 3 0 Family 4 glycosyl hydrolase C-terminal domain PQ-loop PF04193.14 EFA79174.1 - 2.5e-24 84.8 8.7 2.1e-14 53.0 0.4 3.2 3 0 0 3 3 3 2 PQ loop repeat DUF2104 PF09877.9 EFA79174.1 - 0.022 15.0 2.7 0.022 15.0 2.7 2.3 2 2 0 2 2 2 0 Predicted membrane protein (DUF2104) NnrS PF05940.12 EFA79174.1 - 0.079 12.3 6.5 0.1 12.0 6.5 1.2 1 0 0 1 1 1 0 NnrS protein 7TMR-DISM_7TM PF07695.11 EFA79174.1 - 0.7 9.8 18.6 0.13 12.1 9.4 2.3 1 1 1 2 2 2 0 7TM diverse intracellular signalling Caps_synth_CapC PF14102.6 EFA79174.1 - 3.4 8.1 10.8 18 5.8 10.6 2.3 1 1 0 1 1 1 0 Capsule biosynthesis CapC IBV_3C PF03620.13 EFA79174.1 - 6.8 7.3 6.0 13 6.4 0.5 2.8 1 1 0 2 2 2 0 IBV 3C protein MutL_C PF08676.11 EFA79175.1 - 4e-15 55.9 0.5 1.7e-14 53.9 0.0 2.4 3 0 0 3 3 3 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EFA79175.1 - 1.9e-08 34.0 0.1 8.3e-08 31.9 0.1 2.1 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFA79175.1 - 5.5e-07 29.5 0.7 5.5e-07 29.5 0.7 2.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFA79175.1 - 4.6e-05 23.9 0.3 0.00017 22.0 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Rieske PF00355.26 EFA79176.1 - 6.9e-13 48.4 0.0 1.3e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EFA79176.1 - 1.9e-09 37.9 0.1 4.3e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region BBS2_Mid PF14783.6 EFA79177.1 - 0.082 12.9 0.0 0.33 11.0 0.0 2.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region DUF3430 PF11912.8 EFA79178.1 - 3.5e-10 40.3 20.1 4.3e-10 40.0 20.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) FNIP PF05725.12 EFA79180.1 - 4.1e-12 46.1 45.8 5.5e-09 36.1 5.6 8.6 6 2 2 8 8 8 4 FNIP Repeat F-box_5 PF18511.1 EFA79180.1 - 0.066 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 EFA79180.1 - 0.074 13.0 0.2 0.39 10.6 0.1 2.2 2 0 0 2 2 2 0 F-box-like MHCassoc_trimer PF08831.10 EFA79180.1 - 0.79 9.8 4.2 29 4.8 0.2 3.1 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain RWP-RK PF02042.15 EFA79181.1 - 7.1e-06 25.9 0.2 1.4e-05 25.0 0.2 1.4 1 0 0 1 1 1 1 RWP-RK domain AlgF PF11182.8 EFA79181.1 - 0.017 15.0 4.6 0.044 13.6 1.8 2.3 2 0 0 2 2 2 0 Alginate O-acetyl transferase AlgF HSP20 PF00011.21 EFA79183.1 - 1.7e-16 60.2 1.7 1.1e-09 38.4 0.2 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA79183.1 - 6.9e-09 35.1 0.1 2.9e-08 33.1 0.1 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFA79183.1 - 0.0043 18.0 1.2 0.027 15.5 1.2 2.1 1 1 0 1 1 1 1 CS domain CHIP_TPR_N PF18391.1 EFA79183.1 - 0.66 10.8 3.9 3.3 8.5 3.9 2.3 1 1 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain FtsX PF02687.21 EFA79184.1 - 1e-12 48.3 25.8 2.3e-09 37.6 11.3 6.8 7 1 1 8 8 8 2 FtsX-like permease family Kelch_6 PF13964.6 EFA79184.1 - 3.4e-11 43.0 0.9 9.8e-09 35.2 0.0 4.3 5 0 0 5 5 5 1 Kelch motif zf-B_box PF00643.24 EFA79184.1 - 0.039 14.1 13.3 0.08 13.1 13.3 1.5 1 0 0 1 1 1 0 B-box zinc finger Jnk-SapK_ap_N PF09744.9 EFA79184.1 - 0.079 13.2 0.6 0.15 12.3 0.6 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Kelch_5 PF13854.6 EFA79184.1 - 0.1 12.6 0.1 0.52 10.4 0.1 2.3 1 0 0 1 1 1 0 Kelch motif CCDC84 PF14968.6 EFA79184.1 - 1.8 8.1 11.4 0.1 12.2 4.6 2.1 2 0 0 2 2 2 0 Coiled coil protein 84 PhyH PF05721.13 EFA79185.1 - 7e-52 176.8 0.0 8.1e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Lipase_GDSL PF00657.22 EFA79186.1 - 1.5e-09 38.1 0.0 2.1e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EFA79186.1 - 8.2e-08 32.8 0.0 1.5e-06 28.7 0.0 2.2 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Mito_carr PF00153.27 EFA79187.1 - 3.4e-67 222.4 1.3 1.6e-22 79.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFA79187.1 - 0.086 12.0 2.6 0.21 10.7 0.3 2.3 2 1 0 3 3 3 0 Gammaproteobacterial serine protease DUF3510 PF12022.8 EFA79187.1 - 0.2 12.1 0.1 1.4 9.3 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) Shisa PF13908.6 EFA79189.1 - 0.5 10.6 8.2 0.67 10.2 8.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PIG-U PF06728.13 EFA79190.1 - 6.8e-64 216.3 36.9 2.4e-58 198.1 25.9 2.2 1 1 1 2 2 2 2 GPI transamidase subunit PIG-U TRIQK PF15168.6 EFA79190.1 - 0.0038 17.1 0.6 0.39 10.6 0.3 2.8 2 0 0 2 2 2 1 Triple QxxK/R motif-containing protein family Orf78 PF06024.12 EFA79190.1 - 0.11 12.8 0.5 0.11 12.8 0.5 4.0 4 1 1 5 5 5 0 Orf78 (ac78) Pox_EPC_I2-L1 PF12575.8 EFA79190.1 - 0.29 11.4 0.1 0.29 11.4 0.1 4.1 4 0 0 4 4 4 0 Poxvirus entry protein complex L1 and I2 TMEM154 PF15102.6 EFA79190.1 - 1.4 8.8 12.6 0.5 10.3 0.2 3.5 4 0 0 4 4 4 0 TMEM154 protein family PH PF00169.29 EFA79192.1 - 8.3e-26 90.6 3.1 2.3e-14 53.8 0.6 3.6 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 EFA79192.1 - 8.2e-06 26.2 4.0 0.71 10.3 2.6 4.5 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 EFA79192.1 - 0.0067 16.8 2.3 0.06 13.7 0.1 2.9 2 1 0 3 3 3 1 Pleckstrin homology domain PH_13 PF16652.5 EFA79192.1 - 0.05 13.4 0.3 11 5.7 0.0 2.6 2 1 1 3 3 3 0 Pleckstrin homology domain Ala_racemase_N PF01168.20 EFA79194.1 - 7.1e-25 87.9 0.0 8.9e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Rh5 PF18515.1 EFA79196.1 - 0.012 14.9 3.1 0.013 14.8 3.1 1.1 1 0 0 1 1 1 0 Rh5 coiled-coil domain YqzH PF14164.6 EFA79196.1 - 0.11 12.6 5.9 0.13 12.4 5.9 1.1 1 0 0 1 1 1 0 YqzH-like protein ERCC4 PF02732.15 EFA79197.1 - 4.3e-13 49.7 0.1 4.3e-13 49.7 0.1 2.8 2 1 0 2 2 2 1 ERCC4 domain HHH_8 PF14716.6 EFA79197.1 - 7.8e-08 32.6 0.0 2.1e-07 31.2 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain Presenilin PF01080.17 EFA79197.1 - 1.7 7.3 14.4 3.3 6.4 14.4 1.4 1 0 0 1 1 1 0 Presenilin Rhomboid PF01694.22 EFA79199.1 - 1.8e-30 106.0 32.9 1e-21 77.5 14.3 2.6 1 1 2 3 3 3 2 Rhomboid family DUF4579 PF15158.6 EFA79199.1 - 0.22 11.3 8.5 0.11 12.2 0.7 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4579) PsaL PF02605.15 EFA79199.1 - 1.4 8.6 7.7 0.23 11.1 0.8 2.5 2 1 0 2 2 2 0 Photosystem I reaction centre subunit XI DUF2583 PF10762.9 EFA79199.1 - 1.4 9.4 6.0 2.1 8.8 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) Abhydrolase_6 PF12697.7 EFA79201.1 - 0.00038 21.1 0.0 0.0005 20.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA79201.1 - 0.025 14.3 0.3 0.051 13.2 0.3 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold APC1_C PF18122.1 EFA79202.1 - 4.7e-20 72.2 0.5 1.6e-19 70.5 0.5 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 EFA79202.1 - 8.5e-08 32.3 8.3 0.39 11.3 0.0 6.4 5 0 0 5 5 5 4 Proteasome/cyclosome repeat ANAPC1 PF12859.7 EFA79202.1 - 0.011 16.3 14.5 0.22 12.1 11.4 4.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 1 PPR PF01535.20 EFA79204.1 - 0.0033 17.6 2.7 13 6.3 0.0 5.0 5 0 0 5 5 5 2 PPR repeat ANAPC3 PF12895.7 EFA79204.1 - 0.028 14.6 0.0 1.5 9.1 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 p450 PF00067.22 EFA79205.1 - 1.5e-53 182.2 0.1 2.1e-53 181.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 EFA79206.1 - 6.9e-66 222.2 1.4 8e-66 221.9 1.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFA79206.1 - 1.6e-50 171.3 5.3 1.9e-50 171.0 5.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFA79206.1 - 1e-12 48.3 2.3 1.5e-12 47.8 2.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA79206.1 - 1.8e-08 34.1 0.7 4.1e-08 33.0 0.7 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA79206.1 - 1.2e-05 24.5 4.6 2.1e-05 23.6 4.1 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFA79206.1 - 0.00038 19.7 2.6 0.00073 18.8 2.6 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 EFA79206.1 - 0.016 14.5 1.1 0.064 12.6 1.3 1.9 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain p450 PF00067.22 EFA79207.1 - 2.8e-105 352.7 0.0 3.2e-105 352.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UCR_hinge PF02320.16 EFA79208.1 - 2.8e-10 40.2 4.2 3.4e-10 40.0 4.2 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein UPF0203 PF05254.12 EFA79208.1 - 0.12 12.7 3.4 0.38 11.0 3.2 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) zf-CCHC PF00098.23 EFA79209.1 - 0.0069 16.4 21.5 0.01 15.9 0.8 3.5 3 1 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.6 EFA79209.1 - 0.22 11.3 7.7 0.84 9.4 0.7 2.4 2 0 0 2 2 2 0 Zinc knuckle Mucin PF01456.17 EFA79209.1 - 0.88 9.6 11.7 1.9 8.4 11.7 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein U79_P34 PF03064.16 EFA79210.1 - 0.0096 15.3 0.5 0.01 15.2 0.5 1.1 1 0 0 1 1 1 1 HSV U79 / HCMV P34 Gelsolin PF00626.22 EFA79213.1 - 2.9e-45 152.0 0.6 1.8e-10 40.5 0.0 5.9 5 0 0 5 5 5 5 Gelsolin repeat VHP PF02209.19 EFA79213.1 - 3e-11 43.2 2.4 6.8e-11 42.1 2.4 1.6 1 0 0 1 1 1 1 Villin headpiece domain TFIIA PF03153.13 EFA79215.1 - 0.0043 17.1 8.1 0.0051 16.9 8.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Erf4 PF10256.9 EFA79215.1 - 0.0055 16.8 0.9 0.074 13.2 0.9 2.4 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF853 PF05872.12 EFA79215.1 - 0.0093 14.6 0.7 0.012 14.2 0.7 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) Spt20 PF12090.8 EFA79215.1 - 0.011 15.4 15.6 0.019 14.6 15.6 1.4 1 0 0 1 1 1 0 Spt20 family Peptidase_S49_N PF08496.10 EFA79215.1 - 0.13 12.4 0.3 0.13 12.4 0.3 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Neur_chan_memb PF02932.16 EFA79215.1 - 0.17 11.9 7.4 0.37 10.8 7.3 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MPM1 PF17234.2 EFA79215.1 - 1 9.6 6.5 1.5 9.1 6.5 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Androgen_recep PF02166.16 EFA79215.1 - 4.8 5.9 9.2 6.4 5.5 9.2 1.1 1 0 0 1 1 1 0 Androgen receptor PEPCK_GTP PF00821.18 EFA79216.1 - 4.1e-175 581.8 0.1 5.2e-175 581.5 0.1 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 EFA79216.1 - 2e-103 344.7 0.0 2.6e-103 344.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain DUF1285 PF06938.11 EFA79216.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1285) zf-CCHH PF10283.9 EFA79217.1 - 9.4e-14 51.1 3.7 1.6e-13 50.4 3.7 1.4 1 0 0 1 1 1 1 PBZ domain FHA_2 PF17913.1 EFA79217.1 - 3.7e-07 30.3 0.0 7.6e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain FHA PF00498.26 EFA79217.1 - 0.0052 17.1 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 FHA domain Macoilin PF09726.9 EFA79217.1 - 0.017 13.7 18.4 0.022 13.4 18.4 1.1 1 0 0 1 1 1 0 Macoilin family Utp14 PF04615.13 EFA79217.1 - 0.18 10.3 27.7 0.25 9.9 27.7 1.1 1 0 0 1 1 1 0 Utp14 protein TFIIF_alpha PF05793.12 EFA79217.1 - 0.37 9.3 30.8 0.52 8.8 30.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Kelch_6 PF13964.6 EFA79219.1 - 6.1e-12 45.4 6.8 3.9e-10 39.6 0.2 5.0 5 1 0 5 5 5 1 Kelch motif zf-B_box PF00643.24 EFA79219.1 - 1e-05 25.6 10.0 2.2e-05 24.5 10.0 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA79219.1 - 0.00033 20.2 2.8 0.00074 19.0 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 EFA79219.1 - 0.0021 18.0 1.6 0.0056 16.6 0.3 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 EFA79219.1 - 0.0035 17.3 1.5 0.2 11.7 0.0 4.0 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA79219.1 - 0.029 14.4 0.9 0.34 11.0 0.2 3.0 3 0 0 3 3 3 0 Kelch motif zf-UBR PF02207.20 EFA79219.1 - 9 6.5 12.8 17 5.7 0.1 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) CSN8_PSD8_EIF3K PF10075.9 EFA79220.1 - 2.2e-27 95.8 0.4 6.9e-27 94.2 0.0 1.9 2 1 0 2 2 2 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EFA79220.1 - 2.2e-06 27.3 0.5 2.7e-06 27.0 0.5 1.1 1 0 0 1 1 1 1 SAC3/GANP family Ins_allergen_rp PF06757.13 EFA79220.1 - 0.027 14.5 0.6 0.063 13.3 0.2 1.8 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification PyocinActivator PF11112.8 EFA79220.1 - 0.26 11.4 1.6 3.6 7.8 0.1 2.9 3 0 0 3 3 3 0 Pyocin activator protein PrtN SRP14 PF02290.15 EFA79221.1 - 6.5e-18 64.9 0.1 7.5e-18 64.7 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle 14kD protein EGF_2 PF07974.13 EFA79222.1 - 0.001 19.4 10.0 0.0022 18.3 10.0 1.6 1 0 0 1 1 1 1 EGF-like domain TMEM154 PF15102.6 EFA79222.1 - 0.0081 16.1 2.1 0.02 14.8 2.1 1.6 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 EFA79222.1 - 0.012 15.4 0.1 0.026 14.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) TIG PF01833.24 EFA79222.1 - 0.013 15.6 0.4 0.013 15.6 0.4 5.1 6 1 0 6 6 6 0 IPT/TIG domain DUF3377 PF11857.8 EFA79222.1 - 0.049 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) B12D PF06522.11 EFA79222.1 - 0.057 13.2 0.0 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Plasmod_Pvs28 PF06247.11 EFA79222.1 - 0.5 10.7 10.0 1.6 9.1 7.3 2.9 2 0 0 2 2 2 0 Pvs28 EGF domain Toxin_2 PF00451.19 EFA79222.1 - 0.7 10.2 5.7 1.8 8.9 5.7 1.7 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 EGF PF00008.27 EFA79222.1 - 3.1 8.2 7.4 6.8 7.1 7.4 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFA79222.1 - 4.5 7.4 6.5 9 6.5 6.5 1.5 1 0 0 1 1 1 0 Tenascin EGF domain DUF4448 PF14610.6 EFA79223.1 - 5.2e-05 23.1 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TIG PF01833.24 EFA79223.1 - 0.0022 18.0 5.1 0.0022 18.0 5.1 4.7 4 1 1 5 5 5 2 IPT/TIG domain EGF_2 PF07974.13 EFA79223.1 - 0.0027 18.0 12.8 0.0056 17.0 12.8 1.5 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA79223.1 - 0.013 15.8 3.6 0.013 15.8 3.6 2.0 2 0 0 2 2 2 0 EB module EGF_Tenascin PF18720.1 EFA79223.1 - 0.014 15.4 7.4 0.031 14.3 7.4 1.5 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 EFA79223.1 - 0.031 14.9 6.0 0.1 13.3 6.0 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF DUF3377 PF11857.8 EFA79223.1 - 0.042 13.8 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Adeno_E3_CR2 PF02439.15 EFA79223.1 - 2.5 7.9 6.0 0.17 11.7 0.4 1.9 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 EGF PF00008.27 EFA79223.1 - 4.1 7.8 10.7 9.2 6.7 10.7 1.6 1 0 0 1 1 1 0 EGF-like domain Kin17_mid PF10357.9 EFA79225.1 - 0.089 12.7 5.4 0.31 11.0 5.3 2.0 1 1 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein HEAT PF02985.22 EFA79225.1 - 0.13 12.5 0.1 3.5 8.1 0.0 3.5 4 0 0 4 4 4 0 HEAT repeat AI-2E_transport PF01594.16 EFA79225.1 - 4.3 6.4 6.1 8.7 5.4 2.4 2.4 2 0 0 2 2 2 0 AI-2E family transporter FANCI_S2 PF14676.6 EFA79225.1 - 5 7.4 9.2 0.67 10.2 0.3 3.2 3 1 0 3 3 3 0 FANCI solenoid 2 Ank_4 PF13637.6 EFA79228.1 - 5.1e-27 93.9 10.7 3.4e-06 27.5 0.1 7.5 5 3 3 8 8 8 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79228.1 - 1.1e-26 93.2 13.0 7.2e-06 26.5 0.2 5.5 2 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79228.1 - 9.6e-24 83.2 15.5 0.0039 17.5 0.1 9.9 4 3 7 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79228.1 - 2.2e-17 61.4 7.2 1.4 9.8 0.1 11.0 11 0 0 11 11 11 4 Ankyrin repeat Ank PF00023.30 EFA79228.1 - 2.3 8.8 8.3 85 3.9 0.2 5.9 7 0 0 7 7 7 0 Ankyrin repeat Membrane_bind PF14564.6 EFA79229.1 - 1.5e-41 141.2 0.0 2.2e-41 140.7 0.0 1.3 1 0 0 1 1 1 1 Membrane binding Crystall_3 PF08964.10 EFA79229.1 - 1.5e-23 82.8 1.6 4.5e-14 52.4 0.1 2.2 1 1 1 2 2 2 2 Beta/Gamma crystallin Ank_2 PF12796.7 EFA79230.1 - 7.3e-22 77.8 1.0 1.4e-05 25.6 0.0 6.1 4 3 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79230.1 - 3.2e-18 65.8 5.9 0.00087 19.8 0.0 8.4 7 3 3 10 10 10 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79230.1 - 2.9e-15 56.1 2.1 0.0018 18.5 0.0 7.4 6 1 3 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79230.1 - 4.2e-13 48.2 12.6 0.65 10.7 0.0 11.7 13 1 1 14 14 14 3 Ankyrin repeat DUF4891 PF16232.5 EFA79230.1 - 0.058 13.9 0.0 9.7 6.8 0.0 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4891) HOOK PF05622.12 EFA79232.1 - 4.2e-05 21.9 1.3 4.8e-05 21.7 1.3 1.0 1 0 0 1 1 1 1 HOOK protein DUF4164 PF13747.6 EFA79232.1 - 0.021 15.1 2.2 0.062 13.6 2.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) V_ATPase_I PF01496.19 EFA79232.1 - 0.025 12.5 2.5 0.028 12.4 2.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EFA79232.1 - 0.034 14.8 2.2 0.034 14.8 2.2 1.7 1 1 1 2 2 2 0 Initiation control protein YabA Tup_N PF08581.10 EFA79232.1 - 0.054 13.8 9.1 0.11 12.9 7.9 2.0 1 1 1 2 2 2 0 Tup N-terminal Phage_GPO PF05929.11 EFA79232.1 - 0.076 12.6 0.8 0.1 12.2 0.8 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Golgin_A5 PF09787.9 EFA79232.1 - 0.14 11.6 11.8 0.16 11.4 11.8 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 5_nucleotid PF05761.14 EFA79232.1 - 0.34 9.8 7.9 0.41 9.5 7.9 1.0 1 0 0 1 1 1 0 5' nucleotidase family POX PF07526.11 EFA79232.1 - 1.2 9.7 6.8 1.6 9.3 6.6 1.3 1 1 0 1 1 1 0 Associated with HOX APG6_N PF17675.1 EFA79232.1 - 2.3 8.7 13.3 21 5.7 13.1 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Glycos_transf_2 PF00535.26 EFA79233.1 - 1.3e-29 103.2 0.6 3.3e-29 101.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glycos_transf_1 PF00534.20 EFA79233.1 - 1.9e-20 73.1 0.0 4.9e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_tranf_2_2 PF10111.9 EFA79233.1 - 1.4e-19 70.6 0.0 1.1e-18 67.7 0.0 2.5 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_1_4 PF13692.6 EFA79233.1 - 2.2e-15 57.2 0.1 4.7e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_tranf_2_3 PF13641.6 EFA79233.1 - 3.2e-09 37.0 0.0 5.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Thioredoxin_6 PF13848.6 EFA79233.1 - 0.0002 21.3 0.3 0.49 10.3 0.3 3.4 3 0 0 3 3 3 2 Thioredoxin-like domain Glyco_transf_4 PF13439.6 EFA79233.1 - 0.0075 16.3 0.0 0.02 14.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_2_3 PF13632.6 EFA79233.1 - 0.0087 16.0 0.0 0.027 14.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_7C PF02709.14 EFA79233.1 - 0.038 13.6 0.1 0.19 11.4 0.0 2.2 2 0 0 2 2 2 0 N-terminal domain of galactosyltransferase Lactamase_B PF00753.27 EFA79234.1 - 1.5e-13 51.2 0.0 2.1e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFA79234.1 - 0.0041 16.7 0.1 0.0065 16.0 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CAP PF00188.26 EFA79235.1 - 1.3e-06 29.2 0.0 1.5e-06 29.0 0.0 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PHM7_cyt PF14703.6 EFA79236.1 - 0.38 11.0 5.0 3.4 7.8 5.0 1.9 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter FNIP PF05725.12 EFA79237.1 - 3e-33 113.7 17.1 4.4e-15 55.6 1.4 4.0 2 1 1 3 3 3 3 FNIP Repeat Pkinase PF00069.25 EFA79237.1 - 4.3e-25 88.6 7.9 1.1e-23 83.9 7.9 2.8 1 1 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFA79237.1 - 2.7e-11 43.7 3.5 2.3e-05 24.8 0.0 4.2 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79237.1 - 3.8e-07 30.2 2.3 0.0034 17.7 0.1 5.0 3 2 2 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79237.1 - 5.8e-07 30.0 0.5 0.00026 21.5 0.1 3.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79237.1 - 0.00012 22.2 1.9 64 4.6 0.0 6.4 6 0 0 6 6 6 0 Ankyrin repeat Kinase-like PF14531.6 EFA79237.1 - 0.01 15.2 0.0 0.14 11.4 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Imm5 PF14423.6 EFA79237.1 - 0.039 14.2 1.2 0.13 12.5 1.2 1.9 1 0 0 1 1 1 0 Immunity protein Imm5 APH PF01636.23 EFA79237.1 - 0.15 12.0 0.0 0.45 10.4 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Med13_C PF06333.12 EFA79238.1 - 2.5 7.3 9.7 2.6 7.2 9.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Tir_receptor_C PF07489.11 EFA79238.1 - 3.7 7.5 9.4 3.9 7.4 9.4 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus SSP160 PF06933.11 EFA79238.1 - 9 4.4 14.1 11 4.1 14.1 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DNase_II PF03265.15 EFA79239.1 - 2e-32 112.8 10.5 3.9e-12 46.1 7.8 3.4 2 1 1 3 3 3 3 Deoxyribonuclease II MapZ_EC1 PF18041.1 EFA79240.1 - 0.011 15.9 0.8 0.031 14.5 0.8 1.7 1 0 0 1 1 1 0 MapZ extracellular domain 1 GoLoco PF02188.17 EFA79240.1 - 0.1 12.2 0.1 0.23 11.0 0.1 1.6 1 0 0 1 1 1 0 GoLoco motif G8 PF10162.9 EFA79241.1 - 5.3e-23 81.4 0.7 2.4e-22 79.3 0.2 2.5 2 0 0 2 2 2 1 G8 domain DUF4097 PF13349.6 EFA79241.1 - 1.7e-06 27.6 4.5 1.7e-06 27.6 4.5 2.2 2 0 0 2 2 2 1 Putative adhesin Glyco_hydro_42C PF08533.10 EFA79241.1 - 0.039 13.7 0.0 0.23 11.2 0.0 2.3 2 0 0 2 2 2 0 Beta-galactosidase C-terminal domain ubiquitin PF00240.23 EFA79242.1 - 2.9e-11 43.0 3.1 9.7e-06 25.2 0.2 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFA79242.1 - 6.9e-07 29.0 2.7 0.0075 16.1 0.6 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like SpoVIF PF14069.6 EFA79242.1 - 0.001 18.8 0.2 0.034 13.9 0.2 2.6 2 1 0 2 2 2 1 Stage VI sporulation protein F Ubiquitin_4 PF18036.1 EFA79242.1 - 0.011 15.8 1.5 0.13 12.3 0.2 2.7 2 2 1 3 3 3 0 Ubiquitin-like domain YukD PF08817.10 EFA79242.1 - 0.024 15.3 0.0 10 6.9 0.0 2.4 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_5 PF18037.1 EFA79242.1 - 0.15 12.4 2.6 1.9 8.9 0.2 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain Trm112p PF03966.16 EFA79243.1 - 7.1e-13 48.9 0.0 1.2e-12 48.2 0.0 1.4 1 1 0 1 1 1 1 Trm112p-like protein zinc_ribbon_4 PF13717.6 EFA79243.1 - 0.04 13.8 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain UAF_Rrn10 PF05234.11 EFA79243.1 - 0.13 12.5 0.0 0.73 10.1 0.0 1.8 1 1 1 2 2 2 0 UAF complex subunit Rrn10 CPP1-like PF11833.8 EFA79244.1 - 6.2 6.4 7.7 2.7 7.6 1.8 2.6 2 1 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like TAF8_C PF10406.9 EFA79245.1 - 3.3e-18 66.0 2.4 3.2e-17 62.8 1.2 3.2 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EFA79245.1 - 4.6e-16 58.6 1.2 7.5e-16 57.9 0.2 1.9 2 0 0 2 2 2 1 Bromodomain associated RRF PF01765.19 EFA79247.1 - 3.4e-45 153.9 1.4 5.3e-45 153.3 1.4 1.3 1 0 0 1 1 1 1 Ribosome recycling factor CBM_14 PF01607.24 EFA79247.1 - 9.3e-05 22.5 4.7 9.3e-05 22.5 4.7 1.9 1 1 0 1 1 1 1 Chitin binding Peritrophin-A domain YtxH PF12732.7 EFA79247.1 - 0.072 13.6 1.3 0.15 12.6 1.3 1.5 1 0 0 1 1 1 0 YtxH-like protein Syntaxin_2 PF14523.6 EFA79247.1 - 0.98 9.8 8.5 5.3 7.5 7.5 2.3 1 1 0 1 1 1 0 Syntaxin-like protein UCH PF00443.29 EFA79248.1 - 2.1e-19 70.0 1.5 1.1e-18 67.6 1.5 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CBM_20 PF00686.19 EFA79248.1 - 6.4e-16 58.0 1.6 4.5e-06 26.5 0.0 3.7 3 0 0 3 3 3 3 Starch binding domain HSBP1 PF06825.12 EFA79249.1 - 8.8e-18 63.9 12.5 4.4e-16 58.5 5.9 2.3 2 0 0 2 2 2 2 Heat shock factor binding protein 1 DUF2333 PF10095.9 EFA79249.1 - 0.012 14.6 5.2 0.018 14.1 5.2 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) IL11 PF07400.11 EFA79249.1 - 0.024 14.3 1.4 0.038 13.6 0.6 1.8 1 1 1 2 2 2 0 Interleukin 11 CDT1_C PF16679.5 EFA79249.1 - 0.069 13.6 9.6 1 9.9 4.7 2.1 1 1 1 2 2 2 0 DNA replication factor Cdt1 C-terminal domain FlaC_arch PF05377.11 EFA79249.1 - 0.084 13.3 1.8 0.26 11.7 1.8 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) GldM_N PF12081.8 EFA79249.1 - 0.1 12.7 6.1 0.12 12.5 6.1 1.1 1 0 0 1 1 1 0 GldM N-terminal domain Allexi_40kDa PF05549.11 EFA79249.1 - 0.12 11.8 8.0 0.015 14.8 3.5 1.6 1 1 1 2 2 2 0 Allexivirus 40kDa protein YvrJ PF12841.7 EFA79249.1 - 0.17 11.4 0.2 0.46 10.0 0.1 1.8 2 0 0 2 2 2 0 YvrJ protein family TssO PF17561.2 EFA79249.1 - 1 9.4 7.6 0.15 12.1 0.3 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO DUF16 PF01519.16 EFA79249.1 - 6.4 7.3 14.0 0.94 10.0 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 IPPT PF01715.17 EFA79251.1 - 1.1e-47 162.8 0.1 1.6e-47 162.3 0.1 1.2 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 EFA79251.1 - 1.3e-08 34.6 0.0 2.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Isopentenyl transferase Hpr_kinase_C PF07475.12 EFA79251.1 - 0.00047 19.7 0.2 0.001 18.6 0.1 1.5 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain AA_kinase PF00696.28 EFA79251.1 - 0.0047 16.5 0.1 0.0094 15.6 0.1 1.5 1 0 0 1 1 1 1 Amino acid kinase family RNA_helicase PF00910.22 EFA79251.1 - 0.011 16.1 0.1 0.091 13.2 0.0 2.6 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 EFA79251.1 - 0.024 14.8 0.0 0.055 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFA79251.1 - 0.027 14.4 1.3 0.075 12.9 0.8 2.0 1 1 1 2 2 2 0 RsgA GTPase ParA PF10609.9 EFA79251.1 - 0.029 13.8 0.7 0.045 13.2 0.7 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase TIP49 PF06068.13 EFA79251.1 - 0.057 12.6 0.2 0.093 11.9 0.2 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_16 PF13191.6 EFA79251.1 - 0.07 13.5 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Macoilin PF09726.9 EFA79251.1 - 0.071 11.7 0.0 0.098 11.2 0.0 1.2 1 0 0 1 1 1 0 Macoilin family AAA PF00004.29 EFA79251.1 - 0.094 13.1 0.0 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFA79251.1 - 0.1 12.6 1.7 0.21 11.6 0.0 2.6 3 1 1 4 4 2 0 AAA domain AAA_22 PF13401.6 EFA79251.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EFA79251.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Rad17 PF03215.15 EFA79251.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 EFA79251.1 - 0.15 11.7 0.2 0.27 10.8 0.2 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFA79251.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EFA79251.1 - 0.18 12.0 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLN5 PF15014.6 EFA79252.1 - 1.1e-20 74.5 3.5 1.8e-20 73.9 3.5 1.2 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 ATG27 PF09451.10 EFA79252.1 - 1.2e-09 38.4 0.0 2e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFA79252.1 - 1.4e-05 24.4 0.1 3e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Med31 PF05669.12 EFA79253.1 - 1.4e-35 121.1 16.8 1.4e-35 121.1 16.8 1.7 2 0 0 2 2 2 1 SOH1 CCDC53 PF10152.9 EFA79253.1 - 0.025 15.0 5.2 0.088 13.2 0.3 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Mucin PF01456.17 EFA79253.1 - 0.61 10.1 32.2 0.24 11.4 25.4 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein NUDE_C PF04880.13 EFA79253.1 - 0.93 9.9 8.7 0.15 12.5 2.5 2.0 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region FSA_C PF10479.9 EFA79253.1 - 1.3 7.1 10.8 2 6.5 10.8 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pex14_N PF04695.13 EFA79253.1 - 5.6 7.6 12.9 1.5 9.5 1.9 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SSP160 PF06933.11 EFA79253.1 - 9.6 4.3 18.4 13 3.8 18.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Ank_2 PF12796.7 EFA79254.1 - 6e-33 113.3 0.0 9.9e-07 29.3 0.0 6.1 1 1 9 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79254.1 - 2.7e-13 50.1 3.3 0.0022 18.5 0.0 8.7 5 2 4 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79254.1 - 3.6e-13 48.4 0.0 3.2 8.6 0.0 8.6 9 0 0 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EFA79254.1 - 3.5e-12 46.3 0.9 0.76 10.2 0.1 9.1 5 4 5 10 10 10 3 Ankyrin repeats (many copies) DUF1489 PF07370.11 EFA79255.1 - 0.15 11.8 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) TFA2_Winged_2 PF18121.1 EFA79256.1 - 3e-12 46.0 2.0 1e-11 44.3 0.3 2.4 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 Sec8_exocyst PF04048.14 EFA79257.1 - 0.034 14.0 2.2 0.038 13.9 0.7 1.7 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain TetR_C_24 PF17932.1 EFA79257.1 - 0.078 13.2 0.2 0.42 10.9 0.1 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2207 PF09972.9 EFA79258.1 - 3.2e-05 22.9 0.4 3.4e-05 22.8 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) LysE PF01810.18 EFA79258.1 - 0.004 16.6 1.3 0.0056 16.2 1.3 1.2 1 0 0 1 1 1 1 LysE type translocator DUF1634 PF07843.11 EFA79258.1 - 0.025 14.7 2.1 0.64 10.1 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1634) SLATT_1 PF18181.1 EFA79258.1 - 0.028 14.3 0.2 0.074 13.0 0.0 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF948 PF06103.11 EFA79258.1 - 0.25 11.6 0.1 0.25 11.6 0.1 3.1 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Phage_holin_3_6 PF07332.11 EFA79258.1 - 0.49 10.5 7.5 0.81 9.8 7.5 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4133 PF13571.6 EFA79258.1 - 1 9.7 6.9 2.1 8.8 6.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4133) DUF1700 PF08006.11 EFA79258.1 - 1.6 8.2 8.3 2.5 7.6 7.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1700) DUF2207 PF09972.9 EFA79259.1 - 0.00048 19.0 0.6 0.00052 18.9 0.6 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) TetR_C_24 PF17932.1 EFA79259.1 - 0.015 15.5 0.1 0.08 13.2 0.0 2.0 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Retrotran_gag_2 PF14223.6 EFA79259.1 - 0.048 13.3 2.0 0.45 10.2 0.2 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Phage_holin_3_6 PF07332.11 EFA79259.1 - 0.11 12.6 4.0 0.19 11.8 4.0 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RTT107_BRCT_6 PF16771.5 EFA79259.1 - 0.84 9.8 5.5 0.44 10.7 0.3 2.3 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain CAP18_C PF12153.8 EFA79260.1 - 0.25 11.2 1.3 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 LPS binding domain of CAP18 (C terminal) Alpha_E1_glycop PF01589.16 EFA79261.1 - 0.035 12.8 0.1 0.036 12.7 0.1 1.1 1 0 0 1 1 1 0 Alphavirus E1 glycoprotein MtrG PF04210.13 EFA79261.1 - 0.079 12.8 0.2 0.22 11.4 0.1 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G HECT PF00632.25 EFA79261.1 - 0.082 12.4 0.3 0.1 12.1 0.3 1.1 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) Prion PF00377.18 EFA79261.1 - 0.12 12.2 4.8 0.079 12.8 2.3 1.8 1 1 1 2 2 2 0 Prion/Doppel alpha-helical domain Ank_2 PF12796.7 EFA79262.1 - 1.8e-22 79.7 3.7 4.6e-06 27.1 0.0 3.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79262.1 - 1.4e-15 57.4 2.2 0.00065 20.2 0.0 5.1 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79262.1 - 2.9e-15 54.8 0.7 0.024 15.1 0.0 6.9 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EFA79262.1 - 4e-13 49.3 0.5 0.018 15.4 0.0 5.7 3 1 3 6 6 6 3 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA79262.1 - 0.00023 21.0 4.7 0.27 10.9 0.1 3.6 2 2 2 4 4 4 2 Multigene family 530 protein Ank PF00023.30 EFA79262.1 - 0.00054 20.3 0.7 8.6 7.0 0.2 4.2 4 0 0 4 4 4 2 Ankyrin repeat OST3_OST6 PF04756.13 EFA79263.1 - 1.2e-08 34.7 2.5 1.4e-08 34.5 2.5 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Ac81 PF05820.11 EFA79263.1 - 2.5 7.6 4.4 0.24 10.9 0.2 1.4 2 0 0 2 2 2 0 Baculoviridae AC81 TrkH PF02386.16 EFA79266.1 - 9.3e-50 169.5 25.0 1.5e-30 106.1 7.9 3.2 1 1 1 2 2 2 2 Cation transport protein Baculo_11_kDa PF06143.11 EFA79268.1 - 0.0067 16.0 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 Baculovirus 11 kDa family LapA_dom PF06305.11 EFA79268.1 - 0.023 14.5 1.3 0.055 13.3 0.2 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Ank_4 PF13637.6 EFA79269.1 - 6.2e-20 71.3 1.0 0.00074 20.0 0.0 7.0 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79269.1 - 2.2e-16 60.2 1.4 4.8e-05 23.9 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79269.1 - 5.1e-16 58.5 4.7 0.0058 16.9 0.1 7.7 5 3 3 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79269.1 - 1.9e-11 43.1 1.4 7.8 7.4 0.0 8.7 10 0 0 10 10 10 2 Ankyrin repeat DUF3447 PF11929.8 EFA79269.1 - 2.7e-08 33.6 8.0 0.039 13.9 0.2 5.8 3 1 2 6 6 6 4 Domain of unknown function (DUF3447) p450 PF00067.22 EFA79271.1 - 1.1e-91 307.9 0.1 1.9e-64 218.2 0.9 2.0 1 1 1 2 2 2 2 Cytochrome P450 DUF5113 PF17140.4 EFA79271.1 - 0.034 13.9 1.1 0.062 13.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) DUF2237 PF09996.9 EFA79271.1 - 0.058 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) SchA_CurD PF04486.12 EFA79271.1 - 0.16 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 SchA/CurD like domain CBS PF00571.28 EFA79272.1 - 2.5e-18 66.2 0.1 1.1e-08 35.4 0.0 4.2 4 0 0 4 4 4 3 CBS domain PRC PF05239.16 EFA79272.1 - 0.032 14.3 0.7 0.11 12.6 0.1 2.3 3 0 0 3 3 3 0 PRC-barrel domain DUF4061 PF13270.6 EFA79272.1 - 0.094 13.0 0.7 0.34 11.3 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) Oxidored_FMN PF00724.20 EFA79273.1 - 1.2e-70 238.5 0.0 1.4e-70 238.3 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFA79273.1 - 0.15 11.2 0.2 1.6 7.8 0.0 2.4 3 0 0 3 3 3 0 Dihydrouridine synthase (Dus) LEA_4 PF02987.16 EFA79274.1 - 0.00069 19.7 2.2 0.0013 18.8 2.2 1.4 1 0 0 1 1 1 1 Late embryogenesis abundant protein RuBisCO_large PF00016.20 EFA79274.1 - 0.082 12.1 0.4 0.097 11.8 0.4 1.1 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain YtxH PF12732.7 EFA79274.1 - 0.17 12.4 2.5 0.39 11.3 2.5 1.7 1 1 0 1 1 1 0 YtxH-like protein Fucokinase PF07959.12 EFA79275.1 - 5e-96 322.1 1.9 1.1e-83 281.4 0.6 2.1 1 1 1 2 2 2 2 L-fucokinase TFIIA_gamma_C PF02751.14 EFA79276.1 - 3.4e-25 87.9 2.0 6e-25 87.1 2.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EFA79276.1 - 1.1e-23 82.9 1.5 1.1e-23 82.9 1.5 1.6 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit, helical domain Aha1_N PF09229.11 EFA79276.1 - 0.039 14.2 2.5 0.052 13.7 0.6 2.0 1 1 0 2 2 2 0 Activator of Hsp90 ATPase, N-terminal FNIP PF05725.12 EFA79278.1 - 8.6e-38 128.2 25.9 2e-14 53.5 0.1 8.2 8 0 0 8 8 8 6 FNIP Repeat F-box_5 PF18511.1 EFA79278.1 - 0.00032 20.2 0.1 0.00065 19.2 0.1 1.5 1 0 0 1 1 1 1 F-box FHA PF00498.26 EFA79278.1 - 0.24 11.7 0.8 3.4 8.1 0.2 3.0 4 0 0 4 4 4 0 FHA domain Metallophos PF00149.28 EFA79279.1 - 1.1e-14 55.4 1.5 1.8e-14 54.8 1.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFA79279.1 - 7.1e-06 26.8 0.2 0.00012 22.9 0.0 2.6 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 EFA79279.1 - 0.0049 17.1 0.0 0.01 16.0 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ank_2 PF12796.7 EFA79281.1 - 4.5e-16 59.2 0.1 1.8e-05 25.2 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79281.1 - 8e-14 50.4 0.6 0.05 14.2 0.0 6.8 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EFA79281.1 - 1.7e-10 40.9 0.4 0.17 12.2 0.1 5.1 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79281.1 - 4.5e-10 39.9 1.1 0.013 16.1 0.1 4.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA79281.1 - 0.0063 16.5 9.4 0.035 14.1 2.1 3.7 1 1 2 3 3 3 3 Domain of unknown function (DUF3447) Egh16-like PF11327.8 EFA79282.1 - 0.00059 20.3 0.7 0.0012 19.4 0.7 1.5 1 0 0 1 1 1 1 Egh16-like virulence factor Fz PF01392.22 EFA79282.1 - 0.00059 20.4 0.3 0.00059 20.4 0.3 2.0 1 1 0 2 2 2 1 Fz domain GCP_N_terminal PF17681.1 EFA79283.1 - 6.3e-77 259.2 1.5 6.3e-77 259.2 1.5 2.4 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFA79283.1 - 1.5e-75 254.5 20.3 1.5e-75 254.5 20.3 2.8 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal PBP1_TM PF14812.6 EFA79283.1 - 6.5 7.2 13.1 5.3 7.5 8.1 3.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Apolipoprotein PF01442.18 EFA79284.1 - 1.3e-09 38.2 27.9 1.3e-06 28.5 16.9 2.6 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EFA79284.1 - 2.6e-08 34.4 25.7 0.00077 20.0 1.2 3.7 1 1 3 4 4 4 3 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 EFA79284.1 - 9.3e-06 25.8 30.3 0.00067 19.8 9.3 2.2 1 1 1 2 2 2 2 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.7 EFA79284.1 - 2.3e-05 24.8 40.6 0.88 10.2 18.7 4.3 1 1 1 2 2 2 1 YtxH-like protein QIL1 PF15884.5 EFA79284.1 - 0.0011 19.5 0.4 0.0011 19.5 0.4 3.1 2 2 1 3 3 3 1 MICOS complex subunit MIC13, QIL1 EspB PF05802.11 EFA79284.1 - 0.0028 17.7 27.8 0.0062 16.6 8.8 2.7 2 2 0 2 2 2 1 Enterobacterial EspB protein ApoO PF09769.9 EFA79284.1 - 0.0062 16.5 9.0 55 3.7 9.0 3.2 1 1 0 1 1 1 0 Apolipoprotein O Prominin PF05478.11 EFA79284.1 - 0.02 12.9 18.7 0.24 9.3 11.8 2.0 1 1 1 2 2 2 0 Prominin Exonuc_VII_L PF02601.15 EFA79284.1 - 0.026 14.1 19.3 0.33 10.5 5.7 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit Mitofilin PF09731.9 EFA79284.1 - 0.034 13.0 40.6 0.75 8.6 29.3 2.0 1 1 1 2 2 2 0 Mitochondrial inner membrane protein Mis12 PF05859.12 EFA79284.1 - 0.044 13.8 10.4 0.14 12.3 0.3 2.8 1 1 1 2 2 2 0 Mis12 protein IDO PF01231.18 EFA79284.1 - 0.1 11.4 12.0 0.16 10.7 12.0 1.4 1 1 0 1 1 1 0 Indoleamine 2,3-dioxygenase CorA PF01544.18 EFA79284.1 - 0.11 11.8 5.9 0.096 12.0 3.7 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Cnd1 PF12717.7 EFA79284.1 - 0.17 11.9 0.9 0.38 10.8 0.9 1.7 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 AT_hook PF02178.19 EFA79284.1 - 0.2 11.6 6.8 0.53 10.3 6.8 1.8 1 0 0 1 1 1 0 AT hook motif Fzo_mitofusin PF04799.13 EFA79284.1 - 0.27 10.8 16.6 1.9 8.0 4.1 3.2 1 1 2 3 3 3 0 fzo-like conserved region DUF3584 PF12128.8 EFA79284.1 - 0.29 8.6 28.7 0.48 7.9 28.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF948 PF06103.11 EFA79284.1 - 0.31 11.3 19.1 2.4 8.4 1.1 4.4 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) Muted PF14942.6 EFA79284.1 - 0.99 9.7 30.0 0.17 12.2 8.2 3.3 1 1 3 4 4 4 0 Organelle biogenesis, Muted-like protein Baculo_PEP_C PF04513.12 EFA79284.1 - 1.6 8.8 5.6 4.8 7.2 0.3 2.9 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4554 PF15091.6 EFA79284.1 - 2.1 7.1 9.7 2.7 6.8 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) DUF2385 PF09539.10 EFA79284.1 - 2.2 8.9 5.0 0.86 10.2 0.3 2.5 2 2 1 3 3 3 0 Protein of unknown function (DUF2385) ATP-synt_B PF00430.18 EFA79284.1 - 2.2 8.4 37.1 0.62 10.2 2.2 3.5 1 1 4 5 5 5 0 ATP synthase B/B' CF(0) DUF1664 PF07889.12 EFA79284.1 - 2.2 8.3 18.1 0.43 10.6 2.3 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3175 PF11373.8 EFA79284.1 - 2.5 8.4 8.9 0.78 9.9 0.1 3.9 2 2 2 4 4 4 0 Protein of unknown function (DUF3175) L31 PF09784.9 EFA79284.1 - 2.5 8.5 5.6 0.5 10.8 1.0 2.3 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 DUF2884 PF11101.8 EFA79284.1 - 2.6 7.5 19.0 0.74 9.3 7.9 2.7 1 1 3 4 4 4 0 Protein of unknown function (DUF2884) Phasin PF05597.11 EFA79284.1 - 3.8 7.5 28.1 4 7.5 4.6 3.7 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) BshC PF10079.9 EFA79284.1 - 5.2 5.7 24.1 0.84 8.3 5.3 2.2 1 1 1 2 2 2 0 Bacillithiol biosynthesis BshC KxDL PF10241.9 EFA79284.1 - 6.5 7.1 16.7 18 5.7 0.3 4.0 1 1 3 4 4 4 0 Uncharacterized conserved protein Phe_tRNA-synt_N PF02912.18 EFA79284.1 - 6.7 6.7 25.3 2.2 8.3 12.9 4.2 3 1 1 4 4 4 0 Aminoacyl tRNA synthetase class II, N-terminal domain YlqD PF11068.8 EFA79284.1 - 9.4 6.6 24.9 1 9.7 2.0 3.0 1 1 0 2 2 2 0 YlqD protein zf-B_box PF00643.24 EFA79285.1 - 1.4e-08 34.7 10.3 2.4e-08 34.0 10.3 1.3 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.21 EFA79285.1 - 0.45 10.8 6.2 0.87 9.9 6.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Ank_2 PF12796.7 EFA79286.1 - 8.7e-25 87.1 4.4 1.9e-05 25.2 0.1 5.7 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79286.1 - 5.3e-23 81.1 10.9 1.3e-05 25.6 0.1 7.9 6 3 3 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79286.1 - 5.4e-18 64.8 5.5 0.25 11.7 0.0 10.0 3 2 8 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79286.1 - 6.3e-17 59.9 5.3 0.13 12.9 0.0 11.1 10 2 2 12 12 12 4 Ankyrin repeat DUF3447 PF11929.8 EFA79286.1 - 3.9e-10 39.5 15.9 0.051 13.5 1.1 6.5 1 1 6 7 7 7 5 Domain of unknown function (DUF3447) Ank PF00023.30 EFA79286.1 - 0.19 12.3 1.5 1.2e+02 3.4 0.0 5.1 7 1 0 7 7 7 0 Ankyrin repeat Dicty_spore_N PF04562.12 EFA79287.1 - 8.5e-07 29.7 14.4 8.5e-07 29.7 14.4 3.6 1 1 1 2 2 2 1 Dictyostelium spore coat protein, N terminus Ribosomal_L27A PF00828.19 EFA79288.1 - 2e-32 112.6 0.2 3.5e-32 111.8 0.2 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A MPLKIP PF15502.6 EFA79289.1 - 7.2e-09 35.7 0.3 3.1e-08 33.7 0.3 2.2 1 1 0 1 1 1 1 M-phase-specific PLK1-interacting protein Mucin PF01456.17 EFA79289.1 - 0.012 15.6 7.1 0.014 15.4 7.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Hexapep PF00132.24 EFA79290.1 - 9.2e-08 31.5 20.4 0.0046 16.6 0.1 4.1 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFA79290.1 - 0.00089 19.0 14.9 0.047 13.4 0.0 3.8 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Phage_head_fibr PF11133.8 EFA79290.1 - 0.013 15.0 0.3 0.017 14.5 0.3 1.2 1 0 0 1 1 1 0 Head fiber protein Maf PF02545.14 EFA79291.1 - 3.3e-37 127.9 0.1 6.1e-37 127.0 0.1 1.4 1 0 0 1 1 1 1 Maf-like protein GNAT_acetyltr_2 PF13718.6 EFA79291.1 - 0.1 12.0 1.0 0.28 10.5 1.0 1.7 1 0 0 1 1 1 0 GNAT acetyltransferase 2 ELM2 PF01448.24 EFA79293.1 - 3.6 8.4 5.9 64 4.4 3.8 3.3 2 1 0 2 2 2 0 ELM2 domain Tnp_P_element PF12017.8 EFA79294.1 - 5.3e-05 22.8 0.2 0.00046 19.7 0.2 2.5 1 1 0 1 1 1 1 Transposase protein SAP130_C PF16014.5 EFA79294.1 - 0.13 11.4 0.6 0.2 10.7 0.6 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus End3 PF12761.7 EFA79294.1 - 0.33 11.1 2.9 0.46 10.6 1.6 1.8 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 MGC-24 PF05283.11 EFA79294.1 - 5.8 7.4 15.1 17 5.8 15.1 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Uricase PF01014.18 EFA79295.1 - 6.7e-42 142.8 0.8 6.3e-20 71.8 0.0 2.1 1 1 1 2 2 2 2 Uricase NTNH_C PF08470.10 EFA79295.1 - 0.087 12.7 4.7 0.78 9.6 1.0 2.4 1 1 1 2 2 2 0 Nontoxic nonhaemagglutinin C-terminal PWI PF01480.17 EFA79296.1 - 5.4e-24 84.3 0.8 1.2e-23 83.2 0.8 1.5 1 0 0 1 1 1 1 PWI domain Ins_allergen_rp PF06757.13 EFA79296.1 - 0.026 14.5 3.5 0.051 13.5 3.5 1.4 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification VIT PF08487.10 EFA79297.1 - 2.3e-26 92.2 0.0 2.3e-26 92.2 0.0 2.2 3 0 0 3 3 3 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EFA79297.1 - 7.6e-24 84.4 0.0 1.4e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFA79297.1 - 9.8e-14 52.0 0.0 9.8e-14 52.0 0.0 2.7 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA79297.1 - 5.1e-09 36.7 0.0 2.4e-08 34.6 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFA79297.1 - 0.0012 18.3 0.0 0.0031 16.9 0.0 1.6 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein HAP2-GCS1 PF10699.9 EFA79298.1 - 1.4e-11 44.2 0.3 2.8e-11 43.2 0.3 1.5 1 0 0 1 1 1 1 Male gamete fusion factor SIR2 PF02146.17 EFA79299.1 - 1.7e-18 67.2 0.0 3.8e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Sir2 family LRR_4 PF12799.7 EFA79299.1 - 7.4 7.1 20.5 0.88 10.1 0.1 5.6 4 2 1 5 5 5 0 Leucine Rich repeats (2 copies) Peptidase_M61_N PF17899.1 EFA79301.1 - 0.085 12.9 0.1 17 5.4 0.0 2.5 2 0 0 2 2 2 0 Peptidase M61 N-terminal domain GnHR_trans PF12369.8 EFA79301.1 - 0.11 13.4 0.3 0.35 11.7 0.3 1.9 1 0 0 1 1 1 0 Gonadotropin hormone receptor transmembrane region DUF4969 PF16339.5 EFA79301.1 - 0.22 11.9 1.3 0.36 11.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4969) RdRP PF05183.12 EFA79302.1 - 1e-122 410.8 0.0 2.3e-122 409.6 0.0 1.6 1 0 0 1 1 1 1 RNA dependent RNA polymerase Helicase_C PF00271.31 EFA79302.1 - 2e-20 73.2 0.2 2e-19 70.0 0.2 3.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2431 PF10354.9 EFA79302.1 - 1.7e-17 64.2 0.5 8.3e-17 62.0 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) ResIII PF04851.15 EFA79302.1 - 1e-13 51.6 0.0 1e-13 51.6 0.0 4.1 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA79302.1 - 4.8e-12 46.0 0.2 7.9e-11 42.0 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Polbeta PF18765.1 EFA79302.1 - 0.0018 18.3 4.0 0.0022 18.0 0.1 3.3 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase YMF19 PF02326.15 EFA79303.1 - 8.5e-06 26.5 10.5 5.1e-05 24.0 10.5 2.4 1 1 0 1 1 1 1 Plant ATP synthase F0 DUF2431 PF10354.9 EFA79304.1 - 1.2e-07 32.1 9.7 0.0014 19.0 0.0 3.9 3 1 1 4 4 4 3 Domain of unknown function (DUF2431) zf-RanBP PF00641.18 EFA79305.1 - 9.5e-07 28.0 32.9 0.016 14.6 7.2 4.2 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others NUP50 PF08911.11 EFA79305.1 - 2.4e-05 24.9 4.7 2.4e-05 24.9 4.7 5.3 4 1 0 4 4 4 1 NUP50 (Nucleoporin 50 kDa) PTPLA PF04387.14 EFA79306.1 - 6.8e-54 182.0 12.2 6.8e-54 182.0 12.2 1.3 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA FNIP PF05725.12 EFA79307.1 - 3.4e-28 97.5 12.8 3.4e-13 49.5 1.0 8.3 4 3 3 8 8 8 6 FNIP Repeat DUF3641 PF12345.8 EFA79307.1 - 0.077 13.0 0.1 8.6 6.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) TLD PF07534.16 EFA79308.1 - 1.3e-23 83.8 1.9 2.4e-23 82.9 1.9 1.5 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFA79308.1 - 6.8e-20 71.2 0.0 1.7e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.7 EFA79310.1 - 2.6e-06 27.9 3.3 7.6 7.2 0.0 6.5 3 2 4 7 7 7 3 Ankyrin repeats (3 copies) Gam PF06064.11 EFA79310.1 - 0.097 12.9 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Host-nuclease inhibitor protein Gam SapB_1 PF05184.15 EFA79311.1 - 1.1e-14 54.1 11.6 8e-10 38.5 2.2 3.1 3 0 0 3 3 3 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA79311.1 - 5.4e-12 45.6 3.4 8.1e-11 41.8 2.3 2.9 2 0 0 2 2 2 1 Saposin-like type B, region 2 TMCO5 PF14992.6 EFA79311.1 - 0.074 12.6 0.6 0.12 11.9 0.6 1.4 1 0 0 1 1 1 0 TMCO5 family Ribosomal_L19e PF01280.20 EFA79312.1 - 1.3e-13 51.3 0.0 1.4e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L19e BSMAP PF12280.8 EFA79313.1 - 9.7 6.4 9.9 0.37 11.0 1.3 2.0 1 1 1 2 2 2 0 Brain specific membrane anchored protein FAM76 PF16046.5 EFA79313.1 - 9.8 5.4 18.2 12 5.1 18.2 1.1 1 0 0 1 1 1 0 FAM76 protein DUF1690 PF07956.11 EFA79313.1 - 9.9 6.6 24.0 40 4.6 11.4 2.2 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) DUF924 PF06041.11 EFA79316.1 - 4.2e-50 170.4 0.1 1.3e-49 168.8 0.1 1.8 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) FSH1 PF03959.13 EFA79316.1 - 6.7e-48 163.1 0.1 1.5e-47 162.1 0.1 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Ank_4 PF13637.6 EFA79316.1 - 6.3e-14 52.1 3.1 0.00012 22.6 0.4 5.6 4 1 0 4 4 4 3 Ankyrin repeats (many copies) LRR_6 PF13516.6 EFA79316.1 - 6.3e-11 41.4 16.3 0.051 13.6 0.1 8.3 8 0 0 8 8 8 4 Leucine Rich repeat Ank_5 PF13857.6 EFA79316.1 - 2.4e-08 34.1 4.0 0.13 12.6 0.1 5.7 4 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79316.1 - 5.7e-08 33.2 1.5 0.0094 16.5 0.1 5.1 3 1 3 6 6 6 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79316.1 - 0.0038 17.6 4.7 1.2e+02 3.8 0.1 7.0 7 0 0 7 7 6 0 Ankyrin repeat DLH PF01738.18 EFA79316.1 - 0.0092 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family SpoU_sub_bind PF08032.12 EFA79316.1 - 0.011 16.0 0.1 1.4 9.3 0.0 4.1 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding Abhydrolase_2 PF02230.16 EFA79316.1 - 0.013 15.4 0.1 0.026 14.3 0.1 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase LRR_1 PF00560.33 EFA79316.1 - 0.056 14.0 0.3 94 4.2 0.0 5.1 4 0 0 4 4 3 0 Leucine Rich Repeat Ank_4 PF13637.6 EFA79317.1 - 7.6e-16 58.3 8.5 0.0069 17.0 0.0 7.9 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79317.1 - 2.2e-12 47.0 7.1 0.037 14.3 0.0 7.1 6 2 2 8 8 8 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79317.1 - 5.6e-11 42.9 2.4 0.0097 16.5 0.0 5.1 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79317.1 - 2e-07 30.7 7.9 3.5 8.5 0.1 9.0 10 0 0 10 10 10 1 Ankyrin repeat BACK PF07707.15 EFA79318.1 - 0.17 12.0 0.1 0.27 11.3 0.1 1.3 1 0 0 1 1 1 0 BTB And C-terminal Kelch Patatin PF01734.22 EFA79319.1 - 1.1e-22 81.3 0.0 2e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Cation_ATPase PF13246.6 EFA79319.1 - 0.059 13.5 0.1 6.2 7.0 0.0 2.8 2 1 0 2 2 2 0 Cation transport ATPase (P-type) DUF543 PF04418.12 EFA79320.1 - 8.5e-06 25.7 0.0 8.5e-06 25.7 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF543) HemX PF04375.14 EFA79320.1 - 0.0011 18.4 2.5 0.0013 18.1 2.5 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF1664 PF07889.12 EFA79320.1 - 0.016 15.2 6.2 0.031 14.3 6.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 EFA79320.1 - 0.034 14.8 8.9 0.27 11.8 8.2 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF5082 PF16888.5 EFA79320.1 - 0.096 13.0 6.8 0.15 12.3 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF349 PF03993.12 EFA79320.1 - 0.11 12.8 8.4 0.19 12.0 8.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Prominin PF05478.11 EFA79320.1 - 0.3 9.0 4.9 0.37 8.7 4.9 1.1 1 0 0 1 1 1 0 Prominin Spore_III_AB PF09548.10 EFA79320.1 - 0.35 10.9 3.9 0.94 9.6 3.9 1.7 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF3138 PF11336.8 EFA79320.1 - 0.37 9.4 4.3 0.47 9.0 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Atg14 PF10186.9 EFA79320.1 - 0.56 9.2 8.3 0.74 8.8 8.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CLZ PF16526.5 EFA79320.1 - 0.7 10.3 5.4 0.79 10.1 2.1 2.1 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phasin PF05597.11 EFA79320.1 - 0.72 9.9 10.3 1.5 8.8 9.9 1.8 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) KxDL PF10241.9 EFA79320.1 - 1.2 9.4 6.2 2 8.8 6.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein NPV_P10 PF05531.12 EFA79320.1 - 1.6 9.3 5.8 1.4 9.5 3.8 1.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.11 EFA79320.1 - 2.7 8.1 10.2 8.2 6.5 3.8 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ApoO PF09769.9 EFA79320.1 - 2.8 7.9 4.9 5.4 7.0 3.3 2.0 1 1 1 2 2 2 0 Apolipoprotein O Spc7 PF08317.11 EFA79320.1 - 2.9 6.7 12.3 7.4 5.4 11.9 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Aha1_N PF09229.11 EFA79321.1 - 5.6e-34 117.3 2.4 5.6e-34 117.3 2.4 4.2 4 1 1 5 5 5 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EFA79321.1 - 1e-14 54.8 0.1 5.8e-14 52.4 0.1 2.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein INCENP_ARK-bind PF03941.15 EFA79321.1 - 9.7e-08 31.8 0.5 9.7e-08 31.8 0.5 4.3 5 0 0 5 5 5 1 Inner centromere protein, ARK binding region BTG PF07742.12 EFA79322.1 - 0.016 15.0 0.1 0.054 13.3 0.1 1.8 1 0 0 1 1 1 0 BTG family Exo_endo_phos PF03372.23 EFA79322.1 - 0.03 13.8 0.1 0.19 11.2 0.1 2.2 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF3038 PF11237.8 EFA79322.1 - 1.6 8.8 7.2 1 9.4 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3038) DX PF01666.17 EFA79322.1 - 4.8 7.7 7.3 0.3 11.6 0.4 2.6 4 0 0 4 4 4 0 DX module Pro-kuma_activ PF09286.11 EFA79323.1 - 7.4e-27 94.4 0.2 1.7e-26 93.2 0.2 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain CN_hydrolase PF00795.22 EFA79324.1 - 1.8e-16 60.3 0.0 2.9e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase 3HCDH_N PF02737.18 EFA79325.1 - 1e-59 201.5 4.4 1.3e-59 201.1 4.4 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EFA79325.1 - 3.3e-36 123.8 0.0 7.7e-36 122.6 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain TrkA_N PF02254.18 EFA79325.1 - 5.9e-05 23.3 1.4 8.3e-05 22.8 0.1 1.9 3 0 0 3 3 3 1 TrkA-N domain Shikimate_DH PF01488.20 EFA79325.1 - 7.5e-05 22.8 1.1 0.00027 21.0 0.7 2.1 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EFA79325.1 - 0.00016 22.2 0.8 0.00048 20.7 0.8 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EFA79325.1 - 0.00031 21.0 0.9 0.00055 20.2 0.9 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 EFA79325.1 - 0.0015 17.8 0.1 0.0022 17.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 EFA79325.1 - 0.005 17.0 2.7 0.022 14.9 2.7 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox PF00070.27 EFA79325.1 - 0.0076 16.8 0.3 0.016 15.7 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EFA79325.1 - 0.0099 15.5 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 EFA79325.1 - 0.016 15.2 1.0 0.029 14.4 0.7 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 EFA79325.1 - 0.019 14.3 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EFA79325.1 - 0.054 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA79325.1 - 0.073 12.6 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DapB_N PF01113.20 EFA79325.1 - 0.14 12.3 1.4 0.3 11.2 1.4 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus FeoC PF09012.10 EFA79325.1 - 0.16 12.1 0.2 16 5.7 0.0 2.6 2 0 0 2 2 2 0 FeoC like transcriptional regulator Ras PF00071.22 EFA79326.1 - 6.2e-58 195.0 0.6 4.2e-37 127.2 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFA79326.1 - 2e-29 102.3 0.1 2.6e-27 95.4 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA79326.1 - 2.3e-09 36.9 0.1 6.9e-08 32.1 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA79326.1 - 0.00023 21.2 0.0 0.00048 20.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA79326.1 - 0.00057 19.8 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFA79326.1 - 0.092 13.0 0.0 0.45 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 EFA79326.1 - 0.11 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 GTP_EFTU PF00009.27 EFA79326.1 - 0.11 12.0 0.0 2.6 7.5 0.0 2.6 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA79326.1 - 0.13 11.6 0.0 0.25 10.6 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region FNIP PF05725.12 EFA79327.1 - 2.3e-21 75.7 44.3 1.4e-05 25.2 5.6 7.9 3 2 4 9 9 9 8 FNIP Repeat DNA_pol_A PF00476.20 EFA79328.1 - 9.1e-76 255.3 0.0 8.9e-74 248.8 0.0 3.0 2 1 0 2 2 2 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 EFA79328.1 - 4.1e-45 153.5 0.0 8.9e-45 152.4 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 EFA79328.1 - 4.8e-25 88.0 0.0 2.1e-24 85.9 0.0 2.3 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold DNA_pol_A_exo1 PF01612.20 EFA79328.1 - 1.9e-13 50.5 0.0 1.1e-12 48.1 0.0 2.4 2 0 0 2 2 2 1 3'-5' exonuclease HHH_5 PF14520.6 EFA79328.1 - 0.029 15.0 0.0 0.099 13.3 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain TFIIE-A_C PF11521.8 EFA79328.1 - 0.5 10.7 13.5 0.026 14.8 2.3 3.2 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha DUF2951 PF11166.8 EFA79328.1 - 1.1 9.5 0.0 1.1 9.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) SOG2 PF10428.9 EFA79328.1 - 6.2 5.9 29.9 12 5.0 29.9 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein MRP-S34 PF16053.5 EFA79329.1 - 2.4e-10 40.2 0.2 2.9e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 RhoGEF PF00621.20 EFA79330.1 - 1.4e-53 181.9 0.6 4.7e-53 180.1 0.6 2.0 1 0 0 1 1 1 1 RhoGEF domain CH PF00307.31 EFA79330.1 - 2.7e-17 62.9 0.0 2.7e-17 62.9 0.0 3.3 4 0 0 4 4 4 1 Calponin homology (CH) domain VHP PF02209.19 EFA79330.1 - 5.5e-14 52.0 4.5 1.3e-13 50.7 4.5 1.7 1 0 0 1 1 1 1 Villin headpiece domain CDC24 PF06395.11 EFA79330.1 - 0.0031 17.7 0.0 0.0088 16.3 0.0 1.7 1 0 0 1 1 1 1 CDC24 Calponin PH PF00169.29 EFA79330.1 - 0.0032 18.0 0.2 0.042 14.4 0.0 2.7 2 0 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 EFA79330.1 - 0.012 15.6 0.0 0.032 14.2 0.0 1.7 1 0 0 1 1 1 0 PH domain IQ PF00612.27 EFA79330.1 - 0.016 15.0 0.1 0.034 13.9 0.1 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif Na_K-ATPase PF00287.18 EFA79330.1 - 0.017 14.3 0.7 0.059 12.5 0.7 1.9 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain PH_11 PF15413.6 EFA79330.1 - 9.9 6.6 7.9 1 9.8 0.1 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain Myb_DNA-binding PF00249.31 EFA79332.1 - 9.6e-27 92.9 7.1 1.4e-12 47.6 2.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA79332.1 - 1.3e-21 76.6 5.4 1.1e-14 54.4 0.3 3.8 2 1 1 3 3 3 2 Myb-like DNA-binding domain PHD PF00628.29 EFA79332.1 - 1.4e-05 24.9 10.8 3.6e-05 23.5 10.8 1.8 1 0 0 1 1 1 1 PHD-finger SLIDE PF09111.10 EFA79332.1 - 0.0068 16.4 3.3 0.18 11.8 0.0 3.8 3 1 1 4 4 4 1 SLIDE RST PF12174.8 EFA79332.1 - 0.059 13.3 0.7 0.6 10.1 0.0 2.6 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Myb_DNA-bind_7 PF15963.5 EFA79332.1 - 0.084 12.8 3.8 0.66 9.9 0.1 3.4 2 1 1 3 3 3 0 Myb DNA-binding like zinc_ribbon_10 PF10058.9 EFA79332.1 - 0.51 10.1 2.9 1.7 8.4 2.9 1.9 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Rap1_C PF11626.8 EFA79332.1 - 0.57 10.3 4.1 0.55 10.4 1.5 2.3 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain zf-piccolo PF05715.13 EFA79332.1 - 0.58 10.4 8.1 1.9 8.7 8.1 1.9 1 0 0 1 1 1 0 Piccolo Zn-finger PHD_2 PF13831.6 EFA79332.1 - 2 8.1 13.1 0.11 12.1 7.3 2.0 2 0 0 2 2 2 0 PHD-finger fragilysinNterm PF16376.5 EFA79333.1 - 0.021 14.6 0.2 0.023 14.4 0.2 1.1 1 0 0 1 1 1 0 N-terminal domain of fragilysin Asparaginase_2 PF01112.18 EFA79333.1 - 0.032 13.2 0.0 0.04 12.9 0.0 1.1 1 0 0 1 1 1 0 Asparaginase Sulfate_transp PF00916.20 EFA79334.1 - 4.5e-54 183.6 15.8 6.5e-54 183.1 15.8 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFA79334.1 - 2.5e-20 72.3 0.2 4.6e-20 71.4 0.2 1.4 1 0 0 1 1 1 1 STAS domain LURAP PF14854.6 EFA79334.1 - 0.0056 16.6 0.3 0.011 15.6 0.3 1.5 1 0 0 1 1 1 1 Leucine rich adaptor protein MFS_1 PF07690.16 EFA79335.1 - 4.8e-25 88.2 58.6 5.3e-20 71.6 29.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFA79335.1 - 1e-19 70.5 22.8 1.8e-19 69.6 22.1 1.7 1 1 1 2 2 2 1 MFS/sugar transport protein PUCC PF03209.15 EFA79335.1 - 2.3e-09 36.8 3.0 4.9e-09 35.7 3.0 1.4 1 0 0 1 1 1 1 PUCC protein Orf78 PF06024.12 EFA79335.1 - 0.066 13.5 4.4 0.22 11.8 4.4 1.9 1 0 0 1 1 1 0 Orf78 (ac78) UPF0016 PF01169.19 EFA79335.1 - 0.19 12.1 7.8 6.2 7.2 2.2 3.3 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 RCC1 PF00415.18 EFA79336.1 - 1.3e-36 125.0 6.5 6.4e-11 42.7 0.0 7.4 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA79336.1 - 1.3e-22 79.1 26.5 1.1e-07 31.5 0.1 6.9 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat FNIP PF05725.12 EFA79336.1 - 8.3e-15 54.7 38.5 3.5e-07 30.3 0.6 7.8 5 2 1 7 7 7 5 FNIP Repeat Kelch_4 PF13418.6 EFA79336.1 - 0.6 10.2 2.4 17 5.5 0.0 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain AMP-binding PF00501.28 EFA79337.1 - 4.6e-86 289.0 0.0 5.7e-86 288.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA79337.1 - 2.4e-16 60.5 0.1 7.1e-16 59.0 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EFA79337.1 - 0.00045 19.2 0.0 0.0063 15.4 0.1 2.1 2 0 0 2 2 2 1 GH3 auxin-responsive promoter VPS13 PF16908.5 EFA79338.1 - 4.3e-40 138.0 1.9 6.5e-40 137.4 1.9 1.2 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EFA79338.1 - 5.5e-39 132.9 1.1 5.5e-39 132.9 1.1 2.5 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 DUF3896 PF13035.6 EFA79338.1 - 0.32 11.2 4.5 0.57 10.4 1.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3896) VPS13_C PF16909.5 EFA79339.1 - 6.1e-57 192.3 0.8 6.1e-57 192.3 0.8 5.0 5 0 0 5 5 5 2 Vacuolar-sorting-associated 13 protein C-terminal GCFC PF07842.12 EFA79339.1 - 4.6e-52 177.3 9.2 1.4e-51 175.8 9.2 1.9 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein VPS13_mid_rpt PF16910.5 EFA79339.1 - 8.4e-46 156.3 7.9 8.4e-46 156.3 7.9 5.4 4 1 1 5 5 5 2 Repeating coiled region of VPS13 SHR-BD PF06650.12 EFA79339.1 - 1.9e-43 148.8 1.2 1.9e-43 148.8 1.2 4.5 3 1 1 4 4 4 1 SHR-binding domain of vacuolar-sorting associated protein 13 G-patch PF01585.23 EFA79339.1 - 9.1e-12 44.7 1.4 2.6e-11 43.2 1.4 1.8 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 EFA79339.1 - 2.8e-10 40.5 13.6 2.8e-10 40.5 13.6 3.7 2 1 1 3 3 3 1 Tuftelin interacting protein N terminal ATG_C PF09333.11 EFA79339.1 - 7.7e-07 29.4 0.1 4.3e-05 23.8 0.0 3.2 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain G-patch_2 PF12656.7 EFA79339.1 - 0.013 15.6 0.1 0.013 15.6 0.1 3.4 2 1 1 3 3 3 0 G-patch domain YL1 PF05764.13 EFA79339.1 - 0.73 9.9 39.9 3.9 7.5 11.9 2.7 2 0 0 2 2 2 0 YL1 nuclear protein Tubulin PF00091.25 EFA79340.1 - 1.9e-67 227.3 0.0 2.8e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFA79340.1 - 1.2e-47 161.2 0.1 1.8e-47 160.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFA79340.1 - 0.00013 21.7 0.0 0.0012 18.6 0.0 2.3 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 EFA79340.1 - 0.056 12.6 0.0 0.091 11.9 0.0 1.2 1 0 0 1 1 1 0 Tubulin like FNIP PF05725.12 EFA79341.1 - 2.8e-24 85.0 12.5 6.8e-13 48.6 0.6 3.7 4 0 0 4 4 4 2 FNIP Repeat Methyltransf_12 PF08242.12 EFA79341.1 - 0.3 11.9 0.2 0.3 11.9 0.2 3.3 3 2 0 3 3 3 0 Methyltransferase domain Aminotran_3 PF00202.21 EFA79342.1 - 6.3e-109 364.3 0.1 7.7e-109 364.0 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFA79342.1 - 3e-07 30.0 0.0 4.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFA79342.1 - 0.0044 16.0 0.0 0.01 14.8 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V SAP PF02037.27 EFA79343.1 - 4.1e-11 42.3 0.5 4.1e-11 42.3 0.5 1.8 2 0 0 2 2 2 1 SAP domain RRM_1 PF00076.22 EFA79343.1 - 0.015 15.1 0.2 0.078 12.8 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HeH PF12949.7 EFA79343.1 - 0.027 14.2 0.1 0.067 12.9 0.1 1.7 1 1 0 1 1 1 0 HeH/LEM domain LETM1 PF07766.13 EFA79343.1 - 0.55 9.5 0.0 0.55 9.5 0.0 3.8 2 1 1 4 4 4 0 LETM1-like protein RSB_motif PF16294.5 EFA79344.1 - 2.9e-10 40.3 0.2 3.6e-10 40.0 0.2 1.1 1 0 0 1 1 1 1 RNSP1-SAP18 binding (RSB) motif Pinin_SDK_memA PF04696.13 EFA79344.1 - 0.017 15.2 0.0 0.021 14.9 0.0 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region ABC_membrane PF00664.23 EFA79345.1 - 1.6e-68 231.4 25.7 3.7e-37 128.5 6.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA79345.1 - 4.3e-51 173.0 1.4 1.3e-29 103.5 0.0 3.2 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EFA79345.1 - 1.5e-11 44.2 1.4 0.0067 15.9 0.0 4.4 2 2 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA79345.1 - 7e-07 28.9 0.3 0.015 15.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFA79345.1 - 1.1e-05 25.4 0.3 0.13 12.3 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA79345.1 - 1.8e-05 24.7 0.0 0.0091 15.9 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFA79345.1 - 0.00017 21.9 2.9 0.024 14.9 0.1 3.6 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EFA79345.1 - 0.00036 21.0 0.9 0.53 10.6 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EFA79345.1 - 0.0014 19.1 1.6 2.2 8.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EFA79345.1 - 0.0017 18.3 0.6 1.9 8.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA79345.1 - 0.0031 17.3 3.4 0.52 10.0 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain TrwB_AAD_bind PF10412.9 EFA79345.1 - 0.0037 16.2 1.2 1.5 7.7 0.1 2.2 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain DUF815 PF05673.13 EFA79345.1 - 0.0044 16.2 0.9 1.3 8.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_30 PF13604.6 EFA79345.1 - 0.0074 16.0 0.1 7 6.3 0.1 2.8 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA79345.1 - 0.014 14.8 1.6 0.89 8.9 0.0 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family DUF87 PF01935.17 EFA79345.1 - 0.014 15.5 6.2 0.092 12.8 0.0 2.8 3 0 0 3 3 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EFA79345.1 - 0.016 14.7 0.1 2.4 7.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EFA79345.1 - 0.02 14.2 0.7 1.9 7.7 0.2 2.4 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EFA79345.1 - 0.021 15.3 0.8 8.6 6.8 0.0 3.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 EFA79345.1 - 0.022 14.5 0.1 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EFA79345.1 - 0.022 14.5 0.6 0.31 10.8 0.2 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 EFA79345.1 - 0.033 13.2 0.0 4.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.6 EFA79345.1 - 0.038 14.5 0.0 6.1 7.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFA79345.1 - 0.075 12.6 1.1 0.97 9.0 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFA79345.1 - 0.1 11.6 0.1 9.4 5.1 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EFA79345.1 - 0.12 12.8 1.2 11 6.5 0.0 3.6 4 0 0 4 4 3 0 RNA helicase AAA_33 PF13671.6 EFA79345.1 - 0.12 12.6 0.4 0.68 10.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EFA79345.1 - 0.19 11.6 0.5 12 5.8 0.1 2.6 2 0 0 2 2 2 0 NTPase Mid2 PF04478.12 EFA79345.1 - 0.28 11.0 0.0 0.28 11.0 0.0 2.4 3 0 0 3 3 1 0 Mid2 like cell wall stress sensor Dynamin_N PF00350.23 EFA79345.1 - 0.58 10.2 7.2 0.93 9.5 0.1 3.0 3 0 0 3 3 3 0 Dynamin family CstA_5TM PF13722.6 EFA79345.1 - 2.1 8.7 5.7 1.4 9.3 1.9 2.4 2 0 0 2 2 2 0 5TM C-terminal transporter carbon starvation CstA DUF393 PF04134.12 EFA79346.1 - 0.14 13.5 0.2 0.38 12.1 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function, DUF393 DUF4298 PF14131.6 EFA79346.1 - 0.42 10.6 5.6 0.16 11.9 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) DUF3724 PF12521.8 EFA79346.1 - 6.5 6.9 10.1 6.6 6.9 0.3 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF3724) EDS1_EP PF18117.1 EFA79347.1 - 0.022 15.2 1.0 0.26 11.8 0.1 2.3 2 0 0 2 2 2 0 Enhanced disease susceptibility 1 protein EP domain TPR_17 PF13431.6 EFA79348.1 - 5.5e-120 383.5 16.3 3e-10 39.7 0.0 11.9 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_11 PF13414.6 EFA79348.1 - 3.5e-26 90.6 31.3 0.067 12.9 0.1 11.3 11 0 0 11 11 11 10 TPR repeat Glyco_hydro_61 PF03443.14 EFA79348.1 - 9.2e-12 45.3 11.8 12 5.8 0.0 9.8 2 1 8 10 10 10 1 Glycosyl hydrolase family 61 NleF_casp_inhib PF16809.5 EFA79348.1 - 5.4e-10 39.4 16.7 22 4.9 0.1 10.1 2 1 8 10 10 10 0 NleF caspase inhibitor YjzC PF14168.6 EFA79348.1 - 9.9e-10 38.6 7.0 3.2 8.2 0.0 9.1 4 3 6 10 10 10 1 YjzC-like protein Lyx_isomer PF07385.12 EFA79348.1 - 2.9e-08 33.2 7.4 44 3.2 0.0 9.2 1 1 9 10 10 10 0 D-lyxose isomerase T3SS_ExsE PF18286.1 EFA79348.1 - 2.1e-06 27.6 0.5 23 5.0 0.0 7.4 8 0 0 8 8 8 0 Type III secretion system ExsE MatP PF06303.12 EFA79348.1 - 7.6e-06 26.4 7.9 6.6 7.4 0.0 8.0 1 1 9 10 10 10 1 MatP N-terminal domain P22_CoatProtein PF11651.8 EFA79348.1 - 0.00047 18.9 4.3 20 3.6 0.0 6.8 1 1 9 10 10 10 0 P22 coat protein - gene protein 5 DUF1153 PF06627.11 EFA79348.1 - 0.0047 17.0 0.0 9.1 6.5 0.0 5.9 10 0 0 10 10 10 1 Protein of unknown function (DUF1153) TPR_2 PF07719.17 EFA79348.1 - 5.3 7.4 22.0 4.6e+02 1.4 0.3 10.4 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA79348.1 - 5.9 6.9 32.3 42 4.2 0.3 8.4 8 0 0 8 8 8 0 Tetratricopeptide repeat PITH PF06201.13 EFA79350.1 - 1.3e-39 135.8 0.1 1.6e-39 135.5 0.1 1.1 1 0 0 1 1 1 1 PITH domain Phage_tail_2 PF06199.11 EFA79350.1 - 0.13 12.3 0.1 0.29 11.2 0.0 1.5 2 0 0 2 2 2 0 Phage tail tube protein VIT1 PF01988.19 EFA79351.1 - 4.5e-49 167.2 2.8 6.3e-49 166.8 2.8 1.2 1 0 0 1 1 1 1 VIT family DUF773 PF05600.12 EFA79352.1 - 4.8e-136 454.5 15.9 5.7e-136 454.2 15.9 1.0 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 CREPT PF16566.5 EFA79352.1 - 0.0028 17.8 6.0 0.27 11.4 0.1 2.9 2 0 0 2 2 2 2 Cell-cycle alteration and expression-elevated protein in tumour DUF4535 PF15054.6 EFA79352.1 - 0.023 14.5 0.5 0.13 12.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) HAUS-augmin3 PF14932.6 EFA79352.1 - 0.67 9.5 8.8 3.5 7.1 3.9 2.4 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 EFA79352.1 - 1.3 9.6 9.0 7.1 7.2 2.2 2.8 2 0 0 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 EFA79352.1 - 3.3 6.5 13.8 0.99 8.2 1.1 2.6 2 1 0 2 2 2 0 Spc7 kinetochore protein RabGAP-TBC PF00566.18 EFA79353.1 - 3.1e-53 180.6 2.2 3.1e-53 180.6 2.2 2.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Cyclin_N PF00134.23 EFA79353.1 - 9.9e-09 35.0 0.4 2.2e-08 33.9 0.4 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Mesd PF10185.9 EFA79353.1 - 0.035 14.1 0.5 0.1 12.5 0.5 1.8 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor CBM49 PF09478.10 EFA79354.1 - 3.8e-08 33.5 0.1 5.6e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Peptidase_M16_M PF16187.5 EFA79355.1 - 7.7e-26 91.0 0.3 1.1e-19 70.8 0.1 2.7 1 1 1 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EFA79355.1 - 2.2e-19 70.2 7.7 1.3e-10 41.6 0.9 3.3 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFA79355.1 - 9.5e-12 45.1 2.0 6.4e-11 42.5 0.1 2.7 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) FNIP PF05725.12 EFA79356.1 - 7.4e-53 176.5 16.1 6.5e-10 39.0 0.6 6.9 5 1 0 6 6 6 6 FNIP Repeat Pkinase PF00069.25 EFA79356.1 - 9.7e-22 77.6 2.0 4.4e-14 52.5 0.1 3.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79356.1 - 2.8e-09 36.6 0.4 0.00038 19.8 0.2 3.2 2 1 1 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EFA79356.1 - 0.029 14.3 0.1 0.045 13.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Dmd PF17587.2 EFA79357.1 - 0.064 13.6 0.0 0.072 13.5 0.0 1.2 1 0 0 1 1 1 0 Discriminator of mRNA degradation AAA PF00004.29 EFA79359.1 - 5.7e-40 136.8 0.2 2.7e-39 134.6 0.1 2.2 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA79359.1 - 4e-13 48.9 0.1 9.8e-13 47.7 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EFA79359.1 - 1.3e-06 28.6 0.1 1.1e-05 25.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFA79359.1 - 4.4e-06 27.2 0.0 0.00011 22.7 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EFA79359.1 - 3e-05 24.0 0.0 0.00013 21.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFA79359.1 - 6.9e-05 23.1 0.6 0.0014 18.9 0.6 2.5 1 1 0 1 1 1 1 AAA domain Prot_ATP_ID_OB PF16450.5 EFA79359.1 - 0.00025 20.9 0.3 0.00068 19.5 0.3 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain RuvB_N PF05496.12 EFA79359.1 - 0.00052 19.8 0.2 0.0014 18.4 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EFA79359.1 - 0.0011 19.1 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFA79359.1 - 0.0014 18.0 0.0 0.0025 17.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EFA79359.1 - 0.0028 17.4 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EFA79359.1 - 0.0029 18.2 0.1 0.027 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EFA79359.1 - 0.0046 16.8 0.0 0.02 14.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFA79359.1 - 0.0086 15.5 0.1 0.02 14.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFA79359.1 - 0.01 16.1 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EFA79359.1 - 0.011 15.2 0.0 0.16 11.4 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Filament PF00038.21 EFA79359.1 - 0.011 15.3 0.5 0.018 14.6 0.5 1.3 1 0 0 1 1 1 0 Intermediate filament protein ATPase PF06745.13 EFA79359.1 - 0.015 14.6 0.0 0.039 13.3 0.0 1.7 1 0 0 1 1 1 0 KaiC TsaE PF02367.17 EFA79359.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FlaC_arch PF05377.11 EFA79359.1 - 0.027 14.9 5.2 0.048 14.1 2.4 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) AAA_24 PF13479.6 EFA79359.1 - 0.035 13.8 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EFA79359.1 - 0.042 13.4 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFA79359.1 - 0.043 13.5 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EFA79359.1 - 0.043 14.2 0.0 0.085 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 EFA79359.1 - 0.05 12.7 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EFA79359.1 - 0.053 13.1 0.2 0.17 11.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.6 EFA79359.1 - 0.058 13.2 1.7 0.47 10.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain APG6_N PF17675.1 EFA79359.1 - 0.08 13.5 1.8 0.18 12.3 1.8 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_19 PF13245.6 EFA79359.1 - 0.087 13.2 0.1 0.72 10.2 0.1 2.4 3 0 0 3 3 2 0 AAA domain ABC_tran PF00005.27 EFA79359.1 - 0.094 13.2 0.3 1 9.8 0.0 2.4 3 0 0 3 3 2 0 ABC transporter SlyX PF04102.12 EFA79359.1 - 0.12 13.0 0.8 0.38 11.4 0.8 1.8 1 0 0 1 1 1 0 SlyX DUF2075 PF09848.9 EFA79359.1 - 0.14 11.4 1.1 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_13 PF13166.6 EFA79359.1 - 0.14 10.8 1.2 5.3 5.6 1.1 2.2 2 0 0 2 2 2 0 AAA domain DUF4286 PF14114.6 EFA79360.1 - 7.4e-19 68.0 0.7 9e-19 67.8 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4286) Clathrin_H_link PF13838.6 EFA79360.1 - 0.066 13.1 0.1 0.14 12.1 0.0 1.5 2 0 0 2 2 2 0 Clathrin-H-link Ank_2 PF12796.7 EFA79361.1 - 2.7e-14 53.5 0.2 0.00017 22.1 0.1 3.8 1 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79361.1 - 2.8e-10 40.2 0.1 16 6.0 0.0 7.4 6 2 2 8 8 8 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79361.1 - 1.2e-09 38.5 0.1 0.026 15.1 0.0 5.6 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79361.1 - 1.6e-08 34.1 0.0 15 6.5 0.0 6.7 6 0 0 6 6 6 2 Ankyrin repeat FNIP PF05725.12 EFA79363.1 - 2.8e-09 37.0 25.1 0.00079 19.5 1.3 6.4 6 2 1 7 7 7 3 FNIP Repeat F-box_5 PF18511.1 EFA79363.1 - 7.1e-05 22.3 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 F-box PYST-C1 PF09690.10 EFA79364.1 - 5.2 6.9 8.9 1.1 9.0 1.5 2.4 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) CH PF00307.31 EFA79365.1 - 4.4e-15 55.8 0.2 4.4e-15 55.8 0.2 3.4 4 0 0 4 4 4 1 Calponin homology (CH) domain GAS2 PF02187.17 EFA79365.1 - 8.2e-11 41.8 0.0 8.2e-11 41.8 0.0 2.1 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain Methyltransf_11 PF08241.12 EFA79366.1 - 1.2e-10 41.9 0.0 1.7e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA79366.1 - 1.1e-08 35.6 0.0 2e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA79366.1 - 2e-06 27.7 0.0 2.3e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA79366.1 - 2.9e-06 26.8 0.0 3.4e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFA79366.1 - 2.9e-06 27.9 0.0 4.2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA79366.1 - 5.4e-06 26.3 0.0 1.7e-05 24.6 0.1 1.7 1 1 1 2 2 2 1 Methyltransferase domain DUF1478 PF07349.11 EFA79367.1 - 0.17 11.8 0.0 18 5.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1478) AbbA_antirepres PF14156.6 EFA79367.1 - 0.68 9.9 17.2 1.4 8.9 0.2 6.1 6 0 0 6 6 6 0 Antirepressor AbbA DNA_repr_REX1B PF14966.6 EFA79367.1 - 0.85 10.3 6.7 0.14 12.8 0.4 3.0 3 0 0 3 3 3 0 DNA repair REX1-B PH_RBD PF12068.8 EFA79367.1 - 1.8 8.0 7.8 6 6.3 0.2 4.4 6 0 0 6 6 6 0 Rab-binding domain (RBD) Phosphoesterase PF04185.14 EFA79369.1 - 1.4e-89 300.8 0.7 2e-89 300.3 0.7 1.1 1 0 0 1 1 1 1 Phosphoesterase family VD10_N PF08476.10 EFA79369.1 - 0.0065 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Viral D10 N-terminal BTB_2 PF02214.22 EFA79370.1 - 9.6e-24 83.6 0.1 2.6e-23 82.2 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EFA79370.1 - 5.6e-11 42.5 0.0 1.1e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Fis1_TPR_C PF14853.6 EFA79370.1 - 1.5e-06 28.2 0.1 3.2e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 EFA79370.1 - 0.00075 20.0 0.0 0.0015 19.0 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA79370.1 - 0.0019 18.4 0.1 0.0033 17.6 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_N PF14852.6 EFA79370.1 - 0.0025 17.4 0.5 0.14 11.8 0.0 2.3 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat TPR_14 PF13428.6 EFA79370.1 - 0.017 15.9 0.0 0.041 14.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA79370.1 - 0.031 14.4 0.4 0.084 13.0 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RILP PF11461.8 EFA79370.1 - 0.048 13.9 1.4 0.13 12.5 1.4 1.7 1 0 0 1 1 1 0 Rab interacting lysosomal protein SRP_TPR_like PF17004.5 EFA79370.1 - 0.069 13.2 0.7 0.12 12.4 0.7 1.4 1 0 0 1 1 1 0 Putative TPR-like repeat Rhodanese PF00581.20 EFA79371.1 - 2.4e-11 44.1 2.1 9.3e-06 26.1 0.0 2.8 2 1 1 3 3 3 2 Rhodanese-like domain TcpA PF05946.12 EFA79371.1 - 0.1 12.7 0.5 0.3 11.2 0.1 1.8 2 0 0 2 2 2 0 Toxin-coregulated pilus subunit TcpA TPT PF03151.16 EFA79372.1 - 1.8e-29 103.0 17.5 1.9e-29 102.9 17.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFA79372.1 - 1.9e-11 44.3 27.3 1e-06 29.0 13.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFA79372.1 - 7.2e-07 28.7 22.2 1.2e-06 27.9 22.2 1.4 1 1 0 1 1 1 1 UAA transporter family TMEM234 PF10639.9 EFA79372.1 - 0.0082 16.2 3.8 0.0082 16.2 3.8 2.2 2 0 0 2 2 2 1 Putative transmembrane family 234 Tail_VII PF17091.5 EFA79372.1 - 2.7 7.9 6.3 7.2 6.6 0.3 3.2 3 0 0 3 3 3 0 Inovirus G7P protein TERB2 PF15101.6 EFA79373.1 - 0.043 13.9 11.4 0.043 13.9 11.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4448 PF14610.6 EFA79373.1 - 0.047 13.5 2.0 0.055 13.2 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Activator_LAG-3 PF11498.8 EFA79373.1 - 0.51 9.3 22.5 0.51 9.2 22.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Roughex PF06020.11 EFA79373.1 - 0.92 8.5 14.7 1 8.4 14.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein LAP1C PF05609.12 EFA79373.1 - 1.6 7.7 13.6 1.8 7.6 13.6 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF5349 PF17298.2 EFA79373.1 - 2 8.1 21.9 2.1 8.0 21.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5349) DUF4175 PF13779.6 EFA79373.1 - 2.2 6.1 22.3 2.4 6.0 22.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Hydin_ADK PF17213.3 EFA79373.1 - 2.3 8.5 9.3 2.5 8.3 9.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain EIIBC-GUT_N PF03612.14 EFA79373.1 - 3.1 7.5 9.0 4.2 7.1 9.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Connexin PF00029.19 EFA79373.1 - 5.3 6.7 6.0 5.7 6.6 6.0 1.2 1 0 0 1 1 1 0 Connexin Rpp20 PF12328.8 EFA79373.1 - 5.5 6.9 10.4 7 6.6 10.4 1.4 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P GCIP PF13324.6 EFA79374.1 - 3.6e-71 239.8 21.8 6e-70 235.8 21.8 2.3 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting BUD22 PF09073.10 EFA79374.1 - 0.0007 19.1 15.2 0.00092 18.7 15.2 1.2 1 0 0 1 1 1 1 BUD22 DUF4820 PF16091.5 EFA79374.1 - 0.013 14.9 8.5 0.011 15.1 6.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Pox_Ag35 PF03286.14 EFA79374.1 - 0.031 14.1 13.9 1 9.2 12.4 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Drc1-Sld2 PF11719.8 EFA79374.1 - 0.6 9.6 15.6 0.79 9.2 15.6 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein PPP4R2 PF09184.11 EFA79374.1 - 0.92 9.0 22.2 1.6 8.3 22.2 1.4 1 0 0 1 1 1 0 PPP4R2 DUF913 PF06025.12 EFA79374.1 - 1.2 8.0 3.8 2 7.3 3.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 EFA79374.1 - 1.9 7.7 3.3 2.3 7.3 3.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 EFA79374.1 - 1.9 8.8 12.2 3.7 7.8 12.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop14 PF04147.12 EFA79374.1 - 2 6.5 28.8 3.5 5.7 28.8 1.3 1 0 0 1 1 1 0 Nop14-like family RP-C_C PF11800.8 EFA79374.1 - 3 7.9 4.3 7.6 6.6 4.3 1.7 1 1 1 2 2 2 0 Replication protein C C-terminal region NPR3 PF03666.13 EFA79374.1 - 3.1 6.5 6.9 4.6 5.9 6.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SDA1 PF05285.12 EFA79374.1 - 6.1 6.2 24.2 9.5 5.5 24.2 1.3 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 EFA79374.1 - 8.8 6.5 30.6 22 5.2 30.6 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Ank_2 PF12796.7 EFA79375.1 - 1.2e-16 61.0 7.7 1.5e-07 31.9 0.2 5.0 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79375.1 - 2.7e-16 59.7 7.9 6.7e-06 26.6 0.1 6.1 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79375.1 - 1.9e-11 44.0 5.7 0.071 13.5 0.4 6.8 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79375.1 - 3.6e-08 33.0 2.4 25 5.9 0.0 8.6 8 2 1 10 10 10 1 Ankyrin repeat Pox_A3L PF05288.11 EFA79375.1 - 0.071 13.1 0.4 18 5.4 0.0 3.6 3 1 0 3 3 3 0 Poxvirus A3L Protein Ephrin_rec_like PF07699.13 EFA79375.1 - 0.11 12.2 0.8 0.24 11.2 0.8 1.5 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF1266 PF06889.11 EFA79375.1 - 0.31 11.1 6.0 0.27 11.2 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1266) SdrD_B PF17210.3 EFA79376.1 - 2.8e-218 710.3 118.3 2.1e-20 73.0 0.3 17.9 17 1 1 18 18 18 17 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA79376.1 - 4.5e-105 344.1 26.7 4e-07 30.2 0.0 15.4 16 0 0 16 16 15 13 Carboxypeptidase regulatory-like domain bMG3 PF11974.8 EFA79376.1 - 1.3e-56 189.0 6.8 0.00016 21.6 0.0 16.1 16 0 0 16 16 16 10 Bacterial alpha-2-macroglobulin MG3 domain SpaA PF17802.1 EFA79376.1 - 7.5e-56 186.4 97.5 0.00025 21.3 0.2 18.2 17 1 0 17 17 17 14 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA79376.1 - 9e-40 134.6 36.8 0.00091 19.2 0.1 14.0 13 0 0 13 13 13 12 CarboxypepD_reg-like domain DUF2012 PF09430.10 EFA79376.1 - 1.3e-34 118.9 5.7 0.23 11.6 0.0 13.9 13 0 0 13 13 13 8 Protein of unknown function (DUF2012) Big_6 PF17936.1 EFA79376.1 - 2.2e-19 69.5 18.6 4.6 7.6 0.0 13.6 13 1 0 13 13 13 2 Bacterial Ig domain DUF1416 PF07210.12 EFA79376.1 - 7.4e-15 54.6 0.0 0.53 10.2 0.0 10.4 11 0 0 11 11 10 1 Protein of unknown function (DUF1416) DUF2141 PF09912.9 EFA79376.1 - 1.5e-13 50.6 27.9 23 4.9 0.0 20.0 16 6 5 22 22 22 0 Uncharacterized protein conserved in bacteria (DUF2141) Y_Y_Y PF07495.13 EFA79376.1 - 3.3e-12 46.2 43.6 1.2 9.2 0.1 14.6 17 1 0 17 17 14 4 Y_Y_Y domain IFP_35_N PF07334.13 EFA79376.1 - 5.7e-10 39.1 9.5 19 5.4 0.0 7.6 7 0 0 7 7 7 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus FlgD_ig PF13860.6 EFA79376.1 - 1.7e-07 31.0 34.1 2.9 7.8 0.1 14.6 13 3 0 13 13 12 1 FlgD Ig-like domain MetallophosN PF16371.5 EFA79376.1 - 9e-07 29.1 38.5 0.022 15.0 0.1 13.5 14 0 0 14 14 14 1 N terminal of Calcineurin-like phosphoesterase fn3_3 PF14686.6 EFA79376.1 - 2.2e-06 27.4 34.2 47 3.9 0.1 14.9 16 1 0 16 16 15 0 Polysaccharide lyase family 4, domain II DUF3244 PF11589.8 EFA79376.1 - 4.4e-05 23.5 26.4 0.23 11.6 0.0 13.2 17 0 0 17 17 15 1 Domain of unknown function (DUF3244) Invasin_D3 PF09134.10 EFA79376.1 - 0.00015 22.0 54.9 0.37 11.1 0.2 13.5 14 0 0 14 14 13 1 Invasin, domain 3 Glyco_hydro2_C5 PF18565.1 EFA79376.1 - 0.0028 17.5 31.9 17 5.3 0.1 11.0 12 0 0 12 12 11 0 Glycoside hydrolase family 2 C-terminal domain 5 Big_1 PF02369.16 EFA79376.1 - 0.0054 16.7 0.1 0.0054 16.7 0.1 10.6 15 0 0 15 15 14 1 Bacterial Ig-like domain (group 1) PBP-Tp47_c PF14888.6 EFA79376.1 - 0.011 15.7 18.2 18 5.3 0.1 8.4 9 0 0 9 9 9 0 Penicillin-binding protein Tp47 domain C bMG10 PF17973.1 EFA79376.1 - 0.016 15.4 1.4 57 3.9 0.0 6.4 9 0 0 9 9 8 0 Bacterial Alpha-2-macroglobulin MG10 domain APOBEC1 PF18769.1 EFA79376.1 - 0.018 15.3 0.1 69 3.8 0.0 5.0 7 0 0 7 7 5 0 APOBEC1 DUF3426 PF11906.8 EFA79376.1 - 0.024 14.8 7.6 11 6.1 0.0 8.0 11 0 0 11 11 11 0 Protein of unknown function (DUF3426) Dioxygenase_C PF00775.21 EFA79376.1 - 0.048 13.1 13.6 17 4.8 0.0 8.4 14 0 0 14 14 14 0 Dioxygenase Aida_C2 PF14186.6 EFA79376.1 - 0.052 13.2 0.3 7.1 6.2 0.0 3.4 3 0 0 3 3 2 0 Cytoskeletal adhesion Put_Phosphatase PF06888.12 EFA79376.1 - 0.1 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative Phosphatase MG4 PF17789.1 EFA79376.1 - 0.19 11.9 9.3 6.4 7.0 0.0 7.1 9 0 0 9 9 9 0 Macroglobulin domain MG4 EMP24_GP25L PF01105.24 EFA79376.1 - 0.22 11.5 29.4 4 7.4 0.0 11.7 9 3 5 14 14 14 0 emp24/gp25L/p24 family/GOLD Inh PF02974.14 EFA79376.1 - 3 8.0 10.2 76 3.5 0.0 7.4 11 0 0 11 11 10 0 Protease inhibitor Inh Arm PF00514.23 EFA79377.1 - 1.1e-67 222.2 20.4 1.1e-11 44.3 0.0 9.1 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat EF-hand_6 PF13405.6 EFA79377.1 - 1.3e-21 74.6 9.4 6.5e-06 25.7 0.1 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 EFA79377.1 - 7.6e-21 72.1 15.7 2.7e-06 26.5 0.1 4.8 4 0 0 4 4 4 4 EF hand HEAT_EZ PF13513.6 EFA79377.1 - 1.4e-20 73.3 3.9 1.2e-05 25.6 0.0 6.5 5 1 1 6 6 6 4 HEAT-like repeat EF-hand_7 PF13499.6 EFA79377.1 - 1.3e-18 67.2 12.0 3.7e-10 40.1 1.7 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFA79377.1 - 7.3e-18 63.2 15.0 1.9e-05 23.9 0.1 4.8 4 0 0 4 4 4 4 EF hand HEAT PF02985.22 EFA79377.1 - 9e-16 56.6 4.6 0.015 15.5 0.0 8.6 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 EFA79377.1 - 1.4e-15 57.5 0.6 0.0023 18.3 0.0 5.9 2 1 5 7 7 7 4 HEAT repeats Arm_3 PF16186.5 EFA79377.1 - 5.4e-13 48.3 2.2 1.4e-12 47.0 2.2 1.7 1 0 0 1 1 1 1 Atypical Arm repeat IBB PF01749.20 EFA79377.1 - 1.7e-12 47.6 3.1 2.7e-12 47.0 1.6 2.2 2 0 0 2 2 2 1 Importin beta binding domain EF-hand_8 PF13833.6 EFA79377.1 - 1.1e-09 38.0 11.3 0.059 13.2 0.1 4.6 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA79377.1 - 0.00068 19.9 3.1 1 9.7 0.7 3.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFA79377.1 - 0.0015 18.4 6.4 0.028 14.4 0.3 4.0 3 2 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFA79377.1 - 0.0071 16.6 0.7 0.15 12.4 0.1 2.8 2 1 0 2 2 2 1 EF-hand domain HEAT_PBS PF03130.16 EFA79377.1 - 0.021 15.5 0.2 85 4.3 0.0 5.1 5 1 0 5 5 4 0 PBS lyase HEAT-like repeat Atx10homo_assoc PF09759.9 EFA79377.1 - 0.032 14.3 0.0 4.3 7.4 0.0 3.0 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain RMMBL PF07521.12 EFA79377.1 - 0.11 12.5 0.1 89 3.1 0.0 3.9 4 0 0 4 4 4 0 Zn-dependent metallo-hydrolase RNA specificity domain ANAPC5 PF12862.7 EFA79378.1 - 0.016 15.2 0.6 0.041 14.0 0.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 Fzo_mitofusin PF04799.13 EFA79378.1 - 2.2 7.8 15.3 1.6 8.3 6.5 2.3 2 0 0 2 2 2 0 fzo-like conserved region Pkinase PF00069.25 EFA79379.1 - 1.3e-75 254.2 0.0 1.5e-75 254.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79379.1 - 4.1e-34 118.0 0.0 5.4e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFA79379.1 - 2.4e-06 27.1 0.0 3.3e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFA79379.1 - 4.3e-05 23.0 0.0 4.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFA79379.1 - 0.00021 20.2 0.0 0.00034 19.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFA79379.1 - 0.057 13.0 0.4 0.084 12.5 0.4 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFA79379.1 - 0.078 12.9 0.0 0.3 11.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family MFS_1 PF07690.16 EFA79380.1 - 5.2e-52 176.9 23.0 5.2e-52 176.9 23.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFA79380.1 - 2e-08 34.0 2.9 2e-08 34.0 2.9 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Arf PF00025.21 EFA79381.1 - 7.3e-66 220.9 0.1 8.3e-66 220.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA79381.1 - 1e-14 54.8 0.0 1.4e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA79381.1 - 2e-12 46.9 0.0 2.4e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA79381.1 - 5.1e-12 45.7 0.1 6e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFA79381.1 - 8.8e-10 38.3 3.5 6.2e-07 28.9 1.6 2.8 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFA79381.1 - 1.8e-08 34.1 0.0 2.2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA79381.1 - 6.1e-06 26.3 0.1 9.5e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EFA79381.1 - 0.0017 17.9 0.6 0.62 9.6 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFA79381.1 - 0.0021 18.0 0.7 1.7 8.6 0.0 2.2 2 0 0 2 2 2 2 NACHT domain ABC_tran PF00005.27 EFA79381.1 - 0.0045 17.5 0.7 0.017 15.6 0.7 1.8 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EFA79381.1 - 0.0065 16.4 0.1 1.6 8.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 EFA79381.1 - 0.0083 15.1 0.1 0.52 9.2 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EFA79381.1 - 0.045 13.9 0.2 0.057 13.6 0.2 1.5 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFA79381.1 - 0.058 12.8 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FeoB_N PF02421.18 EFA79381.1 - 0.074 12.6 1.4 0.24 10.9 1.4 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B SRP54 PF00448.22 EFA79381.1 - 0.08 12.6 0.0 0.18 11.4 0.1 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 EFA79381.1 - 0.082 12.7 0.2 0.16 11.7 0.2 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MACPF PF01823.19 EFA79382.1 - 2.3e-18 67.1 0.4 4.6e-18 66.1 0.4 1.4 1 0 0 1 1 1 1 MAC/Perforin domain CIMR PF00878.18 EFA79382.1 - 0.012 15.6 3.8 0.15 12.1 1.3 2.4 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat Chlam_PMP PF02415.17 EFA79383.1 - 2.8 8.6 5.8 25 5.6 0.0 3.5 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat MACPF PF01823.19 EFA79384.1 - 1.2e-24 87.6 3.1 1.2e-24 87.6 3.1 2.0 2 0 0 2 2 2 1 MAC/Perforin domain Agarase_CBM PF17992.1 EFA79384.1 - 0.0091 15.6 0.0 0.29 10.7 0.0 2.4 2 0 0 2 2 2 1 Agarase CBM like domain Chlam_PMP PF02415.17 EFA79384.1 - 0.031 14.7 4.3 0.51 10.9 2.2 3.4 2 0 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF1565 PF07602.11 EFA79384.1 - 0.087 12.2 5.6 4.2 6.6 5.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1565) MACPF PF01823.19 EFA79385.1 - 5.1e-13 49.6 1.7 6.7e-13 49.2 1.7 1.1 1 0 0 1 1 1 1 MAC/Perforin domain Profilin PF00235.19 EFA79387.1 - 4.2e-05 23.8 0.0 0.0012 19.1 0.0 2.0 1 1 0 1 1 1 1 Profilin RhoGEF PF00621.20 EFA79388.1 - 6.1e-40 137.4 3.7 6.1e-40 137.4 3.7 2.6 3 0 0 3 3 3 1 RhoGEF domain FYVE PF01363.21 EFA79388.1 - 2e-19 69.5 8.7 3.8e-19 68.6 8.7 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EFA79388.1 - 8.5e-09 35.9 1.9 1.6e-08 35.0 0.3 2.4 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 EFA79388.1 - 7.6e-07 29.1 0.6 7.6e-07 29.1 0.6 2.8 3 0 0 3 3 3 1 Pleckstrin homology domain zf-B_box PF00643.24 EFA79388.1 - 0.4 10.9 7.5 0.76 10.0 7.5 1.5 1 0 0 1 1 1 0 B-box zinc finger FYVE_2 PF02318.16 EFA79388.1 - 0.64 10.2 12.9 0.028 14.7 5.6 2.5 3 0 0 3 3 3 0 FYVE-type zinc finger PH_11 PF15413.6 EFA79388.1 - 1.6 9.2 4.4 1.5 9.2 0.1 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain Acyltransferase PF01553.21 EFA79390.1 - 5.1e-10 39.1 0.1 2.6e-09 36.8 0.0 2.1 1 1 1 2 2 2 1 Acyltransferase TPR_2 PF07719.17 EFA79390.1 - 0.0072 16.4 1.2 0.054 13.6 0.0 3.1 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA79390.1 - 0.0092 16.2 0.9 5.1 7.4 0.0 3.2 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFA79390.1 - 0.15 12.4 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TAFII28 PF04719.14 EFA79391.1 - 1.3e-34 118.1 0.1 2.4e-34 117.3 0.1 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region DUF4519 PF15012.6 EFA79391.1 - 0.22 11.7 0.2 0.22 11.7 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DCP2 PF05026.13 EFA79392.1 - 2.1e-12 47.2 0.7 2.1e-12 47.2 0.7 4.2 3 2 1 4 4 4 1 Dcp2, box A domain NUDIX PF00293.28 EFA79392.1 - 1.9e-11 44.1 0.1 5.1e-11 42.7 0.1 1.7 1 0 0 1 1 1 1 NUDIX domain NTS PF15447.6 EFA79392.1 - 0.082 13.4 0.1 0.19 12.3 0.1 1.5 1 0 0 1 1 1 0 N-terminal segments of PfEMP1 MACPF PF01823.19 EFA79393.1 - 1.1e-23 84.4 2.1 1.1e-23 84.4 2.1 2.2 2 0 0 2 2 2 1 MAC/Perforin domain Agarase_CBM PF17992.1 EFA79393.1 - 0.0069 16.0 0.0 0.36 10.4 0.0 2.8 2 0 0 2 2 2 1 Agarase CBM like domain MACPF PF01823.19 EFA79394.1 - 4.7e-19 69.3 2.2 2e-18 67.3 2.2 2.0 1 0 0 1 1 1 1 MAC/Perforin domain CIMR PF00878.18 EFA79394.1 - 3.1e-08 33.8 1.3 0.0021 18.1 0.1 2.7 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EFA79394.1 - 7.6e-05 22.7 0.9 0.00016 21.6 0.9 1.4 1 0 0 1 1 1 1 Autophagy-related protein 27 PA14 PF07691.12 EFA79394.1 - 0.0046 16.8 1.5 0.065 13.0 0.1 2.6 2 0 0 2 2 2 1 PA14 domain PRKCSH_1 PF13015.6 EFA79394.1 - 0.0083 15.8 0.0 0.024 14.3 0.0 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Ole-e-6 PF09253.10 EFA79394.1 - 0.17 11.9 0.4 0.54 10.2 0.4 1.9 1 0 0 1 1 1 0 Pollen allergen ole e 6 UDPG_MGDP_dh_C PF03720.15 EFA79398.1 - 0.096 13.1 0.0 0.18 12.2 0.0 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain MACPF PF01823.19 EFA79399.1 - 3e-22 79.8 0.5 7.7e-22 78.4 0.1 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Chlam_PMP PF02415.17 EFA79399.1 - 0.35 11.4 2.5 2.4 8.8 2.4 2.6 2 0 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat MACPF PF01823.19 EFA79400.1 - 4.7e-18 66.1 0.6 1.5e-17 64.4 0.6 1.9 1 0 0 1 1 1 1 MAC/Perforin domain DUF1565 PF07602.11 EFA79400.1 - 0.0024 17.3 8.6 0.031 13.6 8.5 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1565) Glyco_hydro_9 PF00759.19 EFA79401.1 - 5.7e-122 408.1 7.2 6.6e-122 407.9 7.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 CENP-B_dimeris PF09026.10 EFA79403.1 - 0.31 11.5 5.6 2 8.9 6.3 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Glyoxalase PF00903.25 EFA79404.1 - 1.5e-18 67.2 0.3 1.8e-11 44.4 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFA79404.1 - 4.2e-12 46.3 0.1 2.3e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 EFA79404.1 - 0.00012 22.3 0.0 0.00036 20.7 0.0 1.8 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DUF2226 PF09987.9 EFA79404.1 - 0.023 14.1 0.1 0.035 13.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) Glyoxalase_3 PF13468.6 EFA79404.1 - 0.033 14.3 0.0 29 4.7 0.0 3.7 3 1 0 3 3 3 0 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EFA79404.1 - 0.13 13.1 0.0 18 6.2 0.0 2.4 2 1 0 2 2 2 0 Glyoxalase-like domain XG_FTase PF03254.13 EFA79404.1 - 0.13 10.9 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Xyloglucan fucosyltransferase RRM_5 PF13893.6 EFA79405.1 - 1.6e-30 105.3 0.0 1.6e-24 85.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EFA79405.1 - 3.3e-24 84.5 0.0 9.1e-07 28.6 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 EFA79405.1 - 5.1e-05 23.4 0.0 0.0014 18.8 0.0 2.3 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 EFA79405.1 - 0.00024 20.9 0.1 0.0049 16.7 0.2 2.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EFA79405.1 - 0.002 18.2 0.0 1.8 8.7 0.0 3.0 3 1 0 3 3 3 2 Limkain b1 BRAP2 PF07576.12 EFA79405.1 - 0.06 13.6 0.1 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 BRCA1-associated protein 2 VWA_2 PF13519.6 EFA79406.1 - 7.2e-07 29.8 1.0 2.6e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain ubiquitin PF00240.23 EFA79406.1 - 4.2e-06 26.4 0.0 4.2e-06 26.4 0.0 2.8 3 0 0 3 3 3 1 Ubiquitin family AAA_23 PF13476.6 EFA79406.1 - 0.0013 19.2 0.7 1.3 9.5 0.1 2.7 2 0 0 2 2 2 2 AAA domain Ras PF00071.22 EFA79406.1 - 0.0034 17.0 0.1 0.17 11.5 0.0 2.8 1 1 1 2 2 2 1 Ras family Mucin PF01456.17 EFA79406.1 - 0.015 15.3 20.3 0.037 14.0 20.3 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein OKR_DC_1_N PF03709.15 EFA79406.1 - 0.017 15.4 0.0 0.077 13.3 0.0 2.0 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain AAA_16 PF13191.6 EFA79406.1 - 0.081 13.3 0.0 0.45 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ATPase PF06745.13 EFA79406.1 - 0.099 12.0 0.3 0.59 9.4 0.0 2.1 2 0 0 2 2 2 0 KaiC NAM-associated PF14303.6 EFA79406.1 - 9.9 6.9 8.7 1.1 10.0 3.7 1.9 1 1 1 2 2 2 0 No apical meristem-associated C-terminal domain Adeno_E3_CR2 PF02439.15 EFA79407.1 - 0.0028 17.4 4.8 0.0053 16.5 4.8 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 EFA79407.1 - 0.003 17.5 0.4 0.0058 16.5 0.4 1.5 1 0 0 1 1 1 1 TMEM154 protein family PRIMA1 PF16101.5 EFA79407.1 - 0.016 15.2 0.7 0.043 13.9 0.7 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RIFIN PF02009.16 EFA79407.1 - 0.019 14.9 1.1 0.019 14.9 1.1 1.8 2 0 0 2 2 2 0 Rifin SKG6 PF08693.10 EFA79407.1 - 0.044 13.2 4.4 0.098 12.1 4.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF1180 PF06679.12 EFA79407.1 - 0.19 12.1 0.1 0.3 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Syndecan PF01034.20 EFA79407.1 - 0.93 9.5 3.2 2.1 8.3 3.2 1.5 1 0 0 1 1 1 0 Syndecan domain DUF2418 PF10332.9 EFA79407.1 - 1.6 9.3 4.9 0.47 11.0 0.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2418) fn3 PF00041.21 EFA79408.1 - 2.9e-08 33.9 10.8 1.1e-05 25.7 0.2 4.5 5 1 1 6 6 6 2 Fibronectin type III domain EGF_2 PF07974.13 EFA79408.1 - 9.4e-05 22.7 11.2 0.00032 21.0 11.2 2.0 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA79408.1 - 0.00011 22.4 8.0 0.00032 20.9 8.0 1.9 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EFA79408.1 - 0.039 14.6 7.1 0.23 12.2 7.1 2.5 1 0 0 1 1 1 0 Human growth factor-like EGF I-EGF_1 PF18372.1 EFA79408.1 - 0.44 10.7 5.7 1.4 9.0 5.7 1.9 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 Toxin_2 PF00451.19 EFA79408.1 - 0.52 10.7 6.6 1.4 9.3 6.6 1.7 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 EGF_Tenascin PF18720.1 EFA79408.1 - 0.92 9.6 10.6 0.019 15.0 3.1 2.2 2 0 0 2 2 2 0 Tenascin EGF domain PH PF00169.29 EFA79409.1 - 0.00039 20.9 0.0 0.00088 19.8 0.0 1.6 1 0 0 1 1 1 1 PH domain BLYB PF05289.11 EFA79409.1 - 0.008 16.4 0.1 0.019 15.1 0.1 1.6 1 0 0 1 1 1 1 Borrelia hemolysin accessory protein ORF6C PF10552.9 EFA79409.1 - 0.092 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 ORF6C domain Amino_oxidase PF01593.24 EFA79410.1 - 9.9e-69 232.8 0.0 1.4e-68 232.3 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA79410.1 - 1.6e-18 66.7 0.2 3.7e-18 65.5 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA79410.1 - 1.7e-09 37.7 0.0 2.2e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFA79410.1 - 2.7e-08 33.3 0.1 6.2e-08 32.1 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 EFA79410.1 - 3e-06 26.7 1.7 0.0025 17.1 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFA79410.1 - 3.4e-06 26.0 0.1 6.6e-06 25.1 0.0 1.4 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EFA79410.1 - 4.1e-06 26.4 0.0 5.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFA79410.1 - 5e-06 25.9 0.1 9.3e-06 25.0 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EFA79410.1 - 3.2e-05 23.3 0.0 6.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA79410.1 - 5e-05 23.8 0.1 0.00021 21.8 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFA79410.1 - 0.00016 20.9 0.1 0.00044 19.5 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFA79410.1 - 0.004 16.5 0.0 0.007 15.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain GDI PF00996.18 EFA79410.1 - 0.019 13.5 0.1 0.043 12.3 0.1 1.6 1 0 0 1 1 1 0 GDP dissociation inhibitor AlaDh_PNT_C PF01262.21 EFA79410.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EFA79410.1 - 0.076 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein JIP_LZII PF16471.5 EFA79411.1 - 0.032 14.4 2.0 0.032 14.4 2.0 3.5 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II Aldedh PF00171.22 EFA79412.1 - 7.3e-112 374.2 0.0 8.5e-112 374.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFA79412.1 - 0.00097 18.3 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) Not1 PF04054.15 EFA79413.1 - 2e-148 494.2 5.4 2e-148 494.2 5.4 3.4 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EFA79413.1 - 1.9e-85 285.8 10.0 1.9e-85 285.8 10.0 2.9 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EFA79413.1 - 1.6e-54 183.8 0.3 1.6e-54 183.8 0.3 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 EFA79413.1 - 9.3e-32 110.2 1.8 9.3e-32 110.2 1.8 4.0 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_TTP_bind PF16417.5 EFA79413.1 - 2.9e-17 62.5 1.5 2.1e-09 36.8 0.0 4.7 2 2 1 3 3 3 2 CCR4-NOT transcription complex subunit 1 TTP binding domain FRB_dom PF08771.11 EFA79413.1 - 0.044 14.2 4.1 0.63 10.5 0.0 3.5 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain Glutaredoxin2_C PF04399.13 EFA79413.1 - 0.18 11.6 4.5 0.79 9.6 4.5 2.1 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain PCRF PF03462.18 EFA79414.1 - 3e-45 154.5 0.4 3e-45 154.5 0.4 1.7 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EFA79414.1 - 4.2e-33 113.7 1.5 4.2e-33 113.7 1.5 1.9 2 0 0 2 2 2 1 RF-1 domain DUF4918 PF16265.5 EFA79414.1 - 0.0045 16.5 0.0 0.085 12.4 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4918) DUF2664 PF10867.8 EFA79414.1 - 0.16 12.4 5.2 38 4.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2664) DUF2408 PF10303.9 EFA79414.1 - 0.21 12.2 4.2 0.25 11.9 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) SLM4 PF16818.5 EFA79414.1 - 3.8 7.4 9.0 23 4.9 0.1 2.6 2 1 1 3 3 3 0 Protein SLM4 DUF4337 PF14235.6 EFA79414.1 - 4.6 7.3 9.0 3.1 7.9 4.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Abhydro_lipase PF04083.16 EFA79415.1 - 9e-17 60.4 0.1 9e-17 60.4 0.1 2.2 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFA79415.1 - 2.2e-06 27.5 1.5 2.2e-06 27.5 1.5 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA79415.1 - 4e-06 26.3 2.4 4.3e-05 22.9 0.0 2.8 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA79415.1 - 1e-05 26.3 0.0 1.5e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFA79415.1 - 0.088 12.3 0.1 1.8 8.0 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF4407 PF14362.6 EFA79415.1 - 0.17 11.2 3.2 0.3 10.4 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MAT1 PF06391.13 EFA79415.1 - 2.1 8.2 18.9 0.13 12.1 12.8 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 HemX PF04375.14 EFA79415.1 - 3.2 6.9 20.9 5.3 6.2 20.9 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CPSF100_C PF13299.6 EFA79415.1 - 3.8 7.7 10.1 0.25 11.5 3.9 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 EFA79415.1 - 5.6 5.9 9.2 2.5 7.0 5.1 2.1 2 0 0 2 2 2 0 CLN3 protein Pkinase PF00069.25 EFA79416.1 - 5.2e-41 140.7 2.2 1.7e-39 135.8 0.0 2.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79416.1 - 1.3e-15 57.4 0.1 2.9e-13 49.7 0.1 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase SGL PF08450.12 EFA79417.1 - 8.6e-66 222.0 0.0 1.1e-65 221.7 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 EFA79417.1 - 0.0058 16.7 0.6 1.8 9.1 0.0 3.6 3 0 0 3 3 3 1 Two component regulator propeller PD40 PF07676.12 EFA79417.1 - 0.012 15.5 0.2 1.4 9.0 0.0 3.0 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Mitofilin PF09731.9 EFA79418.1 - 0.0038 16.1 32.8 0.005 15.8 32.8 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein GREB1 PF15782.5 EFA79418.1 - 0.031 11.4 26.1 0.035 11.3 26.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 EFA79418.1 - 0.062 11.6 46.3 0.075 11.3 46.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 EFA79418.1 - 0.069 11.7 33.8 0.093 11.3 33.8 1.2 1 0 0 1 1 1 0 Macoilin family Dapper PF15268.6 EFA79418.1 - 0.22 10.3 38.5 0.25 10.1 38.5 1.0 1 0 0 1 1 1 0 Dapper SOBP PF15279.6 EFA79418.1 - 0.28 11.8 30.9 0.43 11.1 30.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3523 PF12037.8 EFA79418.1 - 0.39 10.1 37.7 0.53 9.6 37.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) LAP1C PF05609.12 EFA79418.1 - 0.53 9.3 31.4 0.7 8.9 31.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PepSY_TM PF03929.16 EFA79418.1 - 0.63 9.7 11.2 1 9.0 11.2 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Caldesmon PF02029.15 EFA79418.1 - 0.84 8.3 41.8 1 8.1 41.8 1.1 1 0 0 1 1 1 0 Caldesmon Borrelia_P83 PF05262.11 EFA79418.1 - 0.93 7.9 33.1 1.1 7.7 33.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein TPR_17 PF13431.6 EFA79419.1 - 6.1e-07 29.4 0.2 0.031 14.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Kelch_4 PF13418.6 EFA79421.1 - 6.5e-37 125.3 22.9 1.8e-09 37.4 0.0 7.3 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA79421.1 - 7.9e-34 114.8 13.3 3.1e-07 30.5 0.2 6.1 4 2 2 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EFA79421.1 - 1.1e-31 108.3 7.2 3.7e-06 26.8 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFA79421.1 - 8.8e-31 105.6 30.5 4.1e-08 33.3 0.3 7.4 8 2 0 8 8 8 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA79421.1 - 7.6e-27 92.2 11.8 2.2e-05 24.3 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EFA79421.1 - 2.5e-25 87.8 6.4 1.8e-05 24.2 0.1 5.5 5 0 0 5 5 5 5 Kelch motif LodA_N PF17990.1 EFA79421.1 - 0.54 10.2 0.0 0.54 10.2 0.0 3.1 4 0 0 4 4 4 0 L-Lysine epsilon oxidase N-terminal TFIIA PF03153.13 EFA79421.1 - 2.2 8.2 37.1 3 7.7 37.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hira PF07569.11 EFA79422.1 - 4.3e-42 144.3 0.5 4.3e-42 144.3 0.5 3.4 4 1 0 4 4 4 1 TUP1-like enhancer of split WD40 PF00400.32 EFA79422.1 - 6.5e-25 86.9 13.9 3.4e-09 37.2 1.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA79422.1 - 6.2e-09 36.0 0.4 0.039 14.2 0.0 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 EFA79422.1 - 7.3e-08 32.1 0.2 1.4e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region PD40 PF07676.12 EFA79422.1 - 0.00021 21.1 2.3 0.027 14.4 0.3 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EFA79422.1 - 0.00085 18.7 1.1 0.15 11.4 0.9 2.4 2 0 0 2 2 2 2 WD40-like domain Inhibitor_I78 PF11720.8 EFA79422.1 - 0.014 15.4 0.0 0.049 13.7 0.0 1.9 1 0 0 1 1 1 0 Peptidase inhibitor I78 family HIRA_B PF09453.10 EFA79422.1 - 0.058 13.3 0.5 0.18 11.7 0.5 1.9 1 0 0 1 1 1 0 HIRA B motif Lactamase_B PF00753.27 EFA79423.1 - 4.1e-05 23.7 0.0 0.00034 20.7 0.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFA79423.1 - 0.0019 17.8 0.0 0.014 14.9 0.0 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Phosphodiest PF01663.22 EFA79424.1 - 2.3e-42 145.9 0.1 9.4e-30 104.4 0.0 2.4 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase PPR_2 PF13041.6 EFA79424.1 - 4.4e-34 116.4 21.2 1.2e-09 38.2 0.1 8.2 4 3 4 8 8 8 6 PPR repeat family PPR_3 PF13812.6 EFA79424.1 - 1.5e-26 92.2 19.0 7.1e-07 29.2 0.0 6.6 4 1 4 8 8 8 7 Pentatricopeptide repeat domain PPR PF01535.20 EFA79424.1 - 3.9e-21 73.8 11.1 7.2e-06 25.9 0.1 7.1 6 0 0 6 6 6 4 PPR repeat PPR_long PF17177.4 EFA79424.1 - 9.5e-20 70.9 0.1 1.6e-08 34.2 0.0 3.4 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFA79424.1 - 4.1e-10 39.2 16.4 0.007 16.0 0.0 7.5 8 0 0 8 8 8 4 PPR repeat Sulfatase PF00884.23 EFA79424.1 - 0.0001 21.8 0.1 0.00027 20.4 0.1 1.7 1 0 0 1 1 1 1 Sulfatase Exog_C PF18026.1 EFA79424.1 - 0.017 15.2 5.9 3.2 7.9 0.0 4.0 5 0 0 5 5 5 0 Endo/exonuclease (EXOG) C-terminal domain TPR_19 PF14559.6 EFA79424.1 - 0.089 13.3 0.1 0.76 10.3 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat RasGAP PF00616.19 EFA79425.1 - 6.8e-29 101.1 0.2 1.1e-19 71.0 0.1 3.8 3 2 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase BAR_3 PF16746.5 EFA79425.1 - 7e-10 39.0 12.8 7e-10 39.0 12.8 2.4 2 0 0 2 2 2 1 BAR domain of APPL family PCRF PF03462.18 EFA79425.1 - 2.8 7.8 8.8 6.6 6.6 1.2 3.0 4 0 0 4 4 4 0 PCRF domain Pro_isomerase PF00160.21 EFA79426.1 - 1.1e-51 175.2 0.2 9.4e-51 172.2 0.2 1.9 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Na_H_Exchanger PF00999.21 EFA79428.1 - 4.4e-44 150.8 45.8 4.4e-44 150.8 45.8 2.2 2 1 0 2 2 2 1 Sodium/hydrogen exchanger family KH_8 PF17903.1 EFA79428.1 - 0.00048 20.2 0.0 0.0018 18.3 0.0 2.0 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EFA79428.1 - 0.006 16.4 1.6 0.011 15.6 0.3 2.0 2 0 0 2 2 2 1 KH domain GATA PF00320.27 EFA79429.1 - 8.7e-15 54.0 7.9 1.7e-14 53.1 7.9 1.5 1 0 0 1 1 1 1 GATA zinc finger Secretin_N_2 PF07655.13 EFA79429.1 - 0.0013 19.2 9.7 0.0013 19.2 9.7 3.6 3 0 0 3 3 3 1 Secretin N-terminal domain Ribosomal_L6e PF01159.19 EFA79430.1 - 1.6e-37 128.4 3.1 3.9e-37 127.2 0.4 2.5 2 0 0 2 2 2 1 Ribosomal protein L6e Cuticle_3 PF11018.8 EFA79430.1 - 0.026 14.7 2.2 0.044 14.0 2.2 1.3 1 0 0 1 1 1 0 Pupal cuticle protein C1 Ribosomal_L6e_N PF03868.15 EFA79430.1 - 0.036 14.3 0.1 0.036 14.3 0.1 2.5 2 1 0 2 2 2 0 Ribosomal protein L6, N-terminal domain DUF1794 PF08768.11 EFA79431.1 - 3.5e-29 101.7 0.0 4.3e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) Cytochrom_B558a PF05038.13 EFA79431.1 - 0.2 11.2 6.8 0.42 10.2 6.8 1.5 1 1 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Glyco_hydro_20 PF00728.22 EFA79432.1 - 6.1e-86 289.0 1.5 5e-85 286.0 0.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain Telomerase_RBD PF12009.8 EFA79432.1 - 1.3e-13 51.3 0.0 2.6e-12 47.0 0.0 3.2 2 1 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain Glycohydro_20b2 PF14845.6 EFA79432.1 - 4.9e-13 49.9 0.5 4.9e-13 49.9 0.5 3.5 2 2 1 3 3 3 1 beta-acetyl hexosaminidase like RVT_1 PF00078.27 EFA79432.1 - 3.7e-07 29.9 3.1 0.00014 21.4 0.0 3.1 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_hydro_20b PF02838.15 EFA79432.1 - 1.6e-05 25.7 2.0 2.7e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 APOBEC_C PF05240.14 EFA79432.1 - 0.023 14.6 0.1 2.6 8.1 0.0 2.8 2 0 0 2 2 2 0 APOBEC-like C-terminal domain Glyco_hydro_38N PF01074.22 EFA79433.1 - 2.3e-68 230.7 3.1 2.3e-68 230.7 3.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 EFA79433.1 - 6e-14 52.0 0.1 1.1e-13 51.2 0.1 1.4 1 0 0 1 1 1 1 Alpha mannosidase middle domain DUF3674 PF12426.8 EFA79433.1 - 0.11 12.5 0.1 28 4.8 0.0 2.9 2 0 0 2 2 2 0 RNA dependent RNA polymerase GAS PF13851.6 EFA79434.1 - 0.0004 19.8 14.9 0.0004 19.8 14.9 8.4 2 1 7 9 9 9 4 Growth-arrest specific micro-tubule binding APH PF01636.23 EFA79435.1 - 4.5e-18 66.1 0.0 7.4e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Patatin PF01734.22 EFA79436.1 - 8.5e-19 68.5 0.0 1.6e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Glyco_hydro_18 PF00704.28 EFA79437.1 - 1.8e-05 24.6 0.1 2.5e-05 24.2 0.1 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Use1 PF09753.9 EFA79438.1 - 1.3e-25 90.6 29.0 5.4e-20 72.2 25.3 3.0 1 1 1 2 2 2 2 Membrane fusion protein Use1 T2SSF PF00482.23 EFA79438.1 - 0.0099 15.8 0.0 0.036 14.0 0.0 1.9 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F Pox_EPC_I2-L1 PF12575.8 EFA79438.1 - 0.034 14.4 0.2 0.11 12.7 0.2 1.9 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF3671 PF12420.8 EFA79438.1 - 0.07 13.2 2.1 0.21 11.6 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function TFIIA PF03153.13 EFA79438.1 - 1.2 9.0 23.3 1.6 8.6 23.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Q_salvage PF10343.9 EFA79439.1 - 1.9e-40 139.2 0.0 7.5e-40 137.3 0.0 2.0 1 1 1 2 2 2 1 Potential Queuosine, Q, salvage protein family Med26 PF08711.11 EFA79440.1 - 7.4e-08 32.3 0.0 2.6e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 TFIIS helical bundle-like domain GMC_oxred_N PF00732.19 EFA79441.1 - 8.8e-42 143.5 0.0 5.1e-41 141.0 0.0 2.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA79441.1 - 2.2e-27 96.3 0.1 3.9e-27 95.5 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EFA79441.1 - 0.14 12.4 0.5 0.35 11.1 0.5 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Cation_ATPase_C PF00689.21 EFA79442.1 - 3.7e-46 157.1 4.2 3.7e-46 157.1 4.2 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFA79442.1 - 1.5e-34 119.1 3.0 1.5e-34 119.1 3.0 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFA79442.1 - 1.1e-22 79.9 0.0 2.2e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA79442.1 - 1.9e-14 54.4 2.5 4.8e-13 49.9 2.5 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA79442.1 - 3.3e-13 49.1 0.1 2.5e-12 46.3 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA79442.1 - 0.00035 20.4 0.2 0.073 12.8 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF3792 PF12670.7 EFA79442.1 - 0.023 14.9 0.1 0.023 14.9 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3792) DUF4231 PF14015.6 EFA79442.1 - 3.3 8.2 5.2 2.5 8.6 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Arf PF00025.21 EFA79443.1 - 1.2e-66 223.5 0.0 1.5e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA79443.1 - 3e-15 56.5 0.1 7.6e-15 55.2 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA79443.1 - 3.4e-13 49.5 0.0 4.7e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFA79443.1 - 9.4e-11 41.5 0.0 2.2e-10 40.3 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFA79443.1 - 5.2e-10 39.1 0.0 8.3e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA79443.1 - 3.7e-09 36.2 2.2 4.7e-06 26.0 0.6 2.6 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFA79443.1 - 2.5e-06 27.5 0.7 0.00014 21.9 0.0 2.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase TIG PF01833.24 EFA79444.1 - 1.1e-74 246.6 190.0 3.1e-11 43.2 1.6 19.3 19 1 0 19 19 19 16 IPT/TIG domain DNase_II PF03265.15 EFA79444.1 - 3e-48 164.8 0.7 3e-48 164.8 0.7 2.3 2 0 0 2 2 2 1 Deoxyribonuclease II SOG2 PF10428.9 EFA79444.1 - 0.62 9.2 20.9 1 8.5 20.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 EFA79444.1 - 1.5 7.6 17.0 2.3 7.0 17.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EFA79444.1 - 3.3 6.1 14.9 4.9 5.6 14.9 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 EFA79444.1 - 4.3 5.5 17.8 7.3 4.7 17.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SdrD_B PF17210.3 EFA79445.1 - 5.3e-08 33.1 6.4 0.00011 22.4 2.1 7.6 5 2 2 7 7 7 3 SdrD B-like domain Thioredoxin PF00085.20 EFA79447.1 - 9.5e-17 60.9 0.0 1.3e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 EFA79447.1 - 0.00064 19.7 0.0 0.00095 19.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFA79447.1 - 0.094 13.1 0.0 0.25 11.7 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.6 EFA79447.1 - 0.14 12.7 0.0 0.27 11.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain TraF PF13728.6 EFA79447.1 - 0.43 10.4 3.8 3.5 7.4 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Ribosomal_L36e PF01158.18 EFA79448.1 - 4.1e-21 75.0 0.5 1.3e-20 73.4 0.5 1.7 1 1 0 1 1 1 1 Ribosomal protein L36e DKCLD PF08068.12 EFA79448.1 - 0.076 13.1 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 DKCLD (NUC011) domain UPF0113_N PF17833.1 EFA79449.1 - 5.7e-29 100.5 1.1 9.9e-29 99.7 1.1 1.4 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EFA79449.1 - 5.2e-22 77.9 0.0 1.2e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EFA79449.1 - 0.094 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 PUA domain CKS PF01111.19 EFA79450.1 - 1.6e-33 114.8 0.3 1.8e-33 114.6 0.3 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit adh_short PF00106.25 EFA79451.1 - 5.7e-39 133.6 1.8 1.8e-37 128.7 1.8 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA79451.1 - 5.6e-33 114.5 0.8 2.6e-31 109.0 0.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA79451.1 - 0.00016 21.6 1.2 0.0012 18.8 0.5 2.5 1 1 1 2 2 2 1 KR domain HATPase_c PF02518.26 EFA79451.1 - 0.019 15.5 0.1 0.044 14.3 0.1 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1776 PF08643.10 EFA79451.1 - 0.05 13.0 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 EFA79451.1 - 0.072 12.4 0.1 0.9 8.8 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase_NAD PF00670.21 EFA79451.1 - 0.13 12.3 0.5 0.32 11.0 0.5 1.6 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Dak1 PF02733.17 EFA79451.1 - 0.59 9.0 3.8 2.3 7.1 1.6 2.1 2 0 0 2 2 2 0 Dak1 domain Ras PF00071.22 EFA79452.1 - 1.3e-37 128.9 0.0 2.2e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA79452.1 - 6.4e-27 94.2 0.6 2.3e-26 92.4 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA79452.1 - 2.5e-14 53.1 0.0 3.7e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA79452.1 - 2.7e-05 23.7 0.0 2.7e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EFA79452.1 - 3.2e-05 23.7 0.1 0.0015 18.3 0.1 2.4 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFA79452.1 - 0.00017 21.1 1.3 0.00017 21.1 0.0 1.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFA79452.1 - 0.00048 19.7 1.2 0.0029 17.2 1.2 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA79452.1 - 0.00066 19.7 0.0 0.0014 18.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFA79452.1 - 0.002 18.0 0.7 0.011 15.6 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 EFA79452.1 - 0.0032 16.7 6.1 0.018 14.2 0.4 2.9 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 EFA79452.1 - 0.0067 16.4 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain AAA_7 PF12775.7 EFA79452.1 - 0.025 14.1 0.0 0.056 13.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFA79452.1 - 0.061 12.7 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 EFA79452.1 - 0.16 12.3 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Conotoxin PF02950.17 EFA79452.1 - 1.5 9.9 6.6 2.1 9.4 1.4 2.4 2 0 0 2 2 2 0 Conotoxin Rxt3 PF08642.10 EFA79452.1 - 9.6 7.0 7.3 1.8 9.3 2.2 2.0 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Kelch_6 PF13964.6 EFA79454.1 - 3.2e-39 131.9 10.6 4e-08 33.3 0.1 6.7 3 2 3 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EFA79454.1 - 7.9e-39 131.0 18.7 2.3e-08 33.5 0.7 6.9 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFA79454.1 - 2.5e-34 117.0 7.9 6.4e-09 35.7 0.0 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA79454.1 - 3.9e-21 74.8 4.4 0.00016 21.8 0.0 6.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA79454.1 - 2.7e-09 36.8 24.0 0.074 13.1 0.3 6.4 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.15 EFA79454.1 - 4.1e-06 26.5 16.8 0.0011 18.8 0.1 6.0 6 1 1 7 7 7 2 Kelch motif NAD_binding_9 PF13454.6 EFA79454.1 - 1.3 9.0 12.2 2.6 8.0 12.2 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Spt20 PF12090.8 EFA79455.1 - 1.4e-13 51.0 8.6 1.4e-13 51.0 8.6 15.5 5 4 4 9 9 9 1 Spt20 family CitMHS PF03600.16 EFA79456.1 - 7.2e-16 58.2 0.5 1.2e-15 57.5 0.5 1.3 1 0 0 1 1 1 1 Citrate transporter Na_sulph_symp PF00939.19 EFA79456.1 - 0.00063 18.9 7.8 0.0034 16.5 2.5 2.2 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region CAF1A PF12253.8 EFA79457.1 - 9.7e-24 83.3 10.0 9.7e-24 83.3 10.0 5.7 2 1 1 3 3 3 1 Chromatin assembly factor 1 subunit A AHSA1 PF08327.11 EFA79458.1 - 0.00094 19.4 0.3 0.0011 19.2 0.3 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Enolase_C PF00113.22 EFA79459.1 - 7e-137 455.6 0.0 1.1e-136 454.9 0.0 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EFA79459.1 - 9.1e-59 197.3 0.1 1.8e-58 196.4 0.1 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain Polysacc_lyase PF14099.6 EFA79459.1 - 3.7e-26 92.3 1.0 6.8e-26 91.4 1.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase MR_MLE_C PF13378.6 EFA79459.1 - 7.1e-09 35.6 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EFA79459.1 - 0.012 14.8 0.0 0.027 13.6 0.0 1.6 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Peptidase_M28 PF04389.17 EFA79460.1 - 1.3e-22 80.5 0.1 2e-22 79.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFA79460.1 - 1.8e-09 37.6 0.0 3.1e-08 33.6 0.0 2.3 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 EGF_2 PF07974.13 EFA79460.1 - 0.00017 21.9 14.1 0.00044 20.6 14.1 1.8 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA79460.1 - 0.024 14.9 8.8 0.068 13.5 8.8 1.8 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA79460.1 - 0.051 14.2 5.9 0.21 12.3 5.9 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 EFA79460.1 - 0.36 11.0 7.0 0.97 9.6 7.0 1.7 1 0 0 1 1 1 0 Laminin EGF domain EGF_Tenascin PF18720.1 EFA79460.1 - 4.8 7.3 7.6 13 5.9 7.6 1.8 1 0 0 1 1 1 0 Tenascin EGF domain PLDc PF00614.22 EFA79461.1 - 1.2e-13 50.6 1.8 2.2e-06 27.6 0.3 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFA79461.1 - 3e-13 49.8 0.8 1.7e-07 31.2 0.1 3.0 3 1 0 3 3 3 2 PLD-like domain EF-hand_1 PF00036.32 EFA79461.1 - 2.4e-07 29.8 0.4 0.0017 17.8 0.2 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA79461.1 - 4.1e-06 26.3 0.1 0.14 12.2 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EFA79461.1 - 4.6e-05 23.8 0.2 0.00022 21.6 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EFA79461.1 - 0.00039 19.8 1.4 1.2 8.7 0.0 3.0 2 0 0 2 2 2 2 EF hand Sua5_yciO_yrdC PF01300.18 EFA79461.1 - 0.066 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Telomere recombination EF-hand_8 PF13833.6 EFA79461.1 - 0.068 13.0 0.1 10 6.0 0.1 3.3 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_7 PF13499.6 EFA79462.1 - 0.0025 18.2 0.2 0.0099 16.3 0.0 2.1 2 1 0 2 2 2 1 EF-hand domain pair CPSF_A PF03178.15 EFA79463.1 - 3.6e-45 154.7 0.2 8.2e-45 153.5 0.2 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 EFA79463.1 - 5.2e-28 97.9 0.2 5.2e-28 97.9 0.2 2.2 1 1 1 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Chordopox_A13L PF05961.11 EFA79463.1 - 1.8 8.9 5.3 0.85 9.9 0.1 2.8 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Connexin PF00029.19 EFA79463.1 - 6 6.6 8.9 0.77 9.5 0.4 2.9 3 0 0 3 3 3 0 Connexin Presenilin PF01080.17 EFA79463.1 - 6.4 5.4 14.7 0.089 11.6 1.8 2.5 2 0 0 2 2 2 0 Presenilin DAGK_cat PF00781.24 EFA79464.1 - 1.1e-08 34.7 0.1 2e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Aminotran_5 PF00266.19 EFA79465.1 - 1.3e-31 109.9 0.0 2e-31 109.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V MOSC PF03473.17 EFA79465.1 - 1.6e-26 92.9 0.0 3.2e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EFA79465.1 - 8.9e-21 74.0 0.0 2.4e-20 72.6 0.0 1.8 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain TPR_17 PF13431.6 EFA79466.1 - 4.7e-48 158.1 7.7 6.6e-08 32.4 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFA79466.1 - 2.4e-15 55.9 11.6 0.011 15.4 0.2 6.3 6 0 0 6 6 6 5 TPR repeat DUF1153 PF06627.11 EFA79466.1 - 0.0037 17.4 0.1 32 4.7 0.0 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF1153) TPR_20 PF14561.6 EFA79466.1 - 0.0074 16.6 0.5 0.82 10.1 0.5 3.7 4 1 0 4 4 4 1 Tetratricopeptide repeat Lyx_isomer PF07385.12 EFA79466.1 - 0.14 11.4 0.1 12 5.0 0.0 3.6 4 1 1 5 5 5 0 D-lyxose isomerase TPR_2 PF07719.17 EFA79466.1 - 1.3 9.3 12.0 63 4.1 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat A_amylase_inhib PF01356.19 EFA79467.1 - 0.02 14.9 2.0 0.056 13.5 2.0 1.7 1 0 0 1 1 1 0 Alpha amylase inhibitor DUF4564 PF15169.6 EFA79468.1 - 0.02 14.6 2.4 0.021 14.6 2.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4564) Secretin_N_2 PF07655.13 EFA79468.1 - 1.5 9.5 13.6 1.6 9.3 13.6 1.1 1 0 0 1 1 1 0 Secretin N-terminal domain TPR_17 PF13431.6 EFA79469.1 - 7.9e-83 267.1 25.8 1.7e-09 37.4 0.1 12.6 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_11 PF13414.6 EFA79469.1 - 1.7e-25 88.4 36.1 0.0012 18.5 0.1 11.0 11 0 0 11 11 11 9 TPR repeat IMPa_helical PF18642.1 EFA79469.1 - 0.057 13.8 0.0 0.42 11.1 0.0 2.5 2 1 0 2 2 2 0 Immunomodulating metalloprotease helical domain MF_alpha PF04648.12 EFA79469.1 - 0.087 13.1 3.0 22 5.6 0.0 4.4 5 0 0 5 5 5 0 Yeast mating factor alpha hormone Bac_rhamnosid_N PF08531.10 EFA79469.1 - 0.16 11.8 0.9 0.9 9.3 0.1 2.6 2 1 1 3 3 3 0 Alpha-L-rhamnosidase N-terminal domain Anth_Ig PF05587.13 EFA79469.1 - 0.18 12.1 6.1 40 4.6 0.0 5.6 8 0 0 8 8 8 0 Anthrax receptor extracellular domain DUF3324 PF11797.8 EFA79469.1 - 0.21 11.6 9.0 2.5 8.1 3.6 4.3 3 1 2 5 5 5 0 Protein of unknown function C-terminal (DUF3324) TPR_8 PF13181.6 EFA79469.1 - 0.29 11.4 21.3 48 4.5 0.4 11.4 14 1 0 14 14 14 0 Tetratricopeptide repeat WW_FCH_linker PF16623.5 EFA79469.1 - 0.35 11.7 6.6 2.7e+02 2.4 0.1 6.3 6 1 1 8 8 8 0 Unstructured linker region between on GAS7 protein DUF3431 PF11913.8 EFA79469.1 - 0.69 9.6 2.7 5 6.8 0.2 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF3431) Ubiquitin_2 PF14560.6 EFA79469.1 - 5.6 7.5 10.5 16 6.0 0.6 4.2 3 2 1 4 4 4 0 Ubiquitin-like domain A_amylase_inhib PF01356.19 EFA79470.1 - 0.021 14.8 2.0 0.056 13.5 2.0 1.7 1 0 0 1 1 1 0 Alpha amylase inhibitor TPR_17 PF13431.6 EFA79471.1 - 3.2e-92 296.5 21.4 3.2e-10 39.7 0.1 12.2 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_11 PF13414.6 EFA79471.1 - 6.3e-30 102.6 35.7 0.0015 18.2 0.1 11.8 12 0 0 12 12 12 9 TPR repeat HTH_Tnp_Tc5 PF03221.16 EFA79471.1 - 0.00031 20.7 5.1 16 5.6 0.0 6.8 8 0 0 8 8 8 0 Tc5 transposase DNA-binding domain RNase_PH_C PF03725.15 EFA79471.1 - 0.00099 19.1 4.9 0.6 10.2 0.2 5.1 5 1 1 6 6 6 1 3' exoribonuclease family, domain 2 DUF3048_C PF17479.2 EFA79471.1 - 0.015 15.7 1.9 36 4.8 0.2 4.6 3 1 2 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain DUF5643 PF18705.1 EFA79471.1 - 0.02 14.9 1.8 3.7 7.5 0.1 3.4 2 0 0 2 2 2 0 Family of unknown function (DUF5643) TPR_14 PF13428.6 EFA79471.1 - 0.03 15.1 0.1 1.6e+02 3.5 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat HrpJ PF07201.11 EFA79471.1 - 0.039 14.3 11.3 0.54 10.6 0.8 4.7 5 0 0 5 5 5 0 HrpJ-like domain TPR_19 PF14559.6 EFA79471.1 - 0.066 13.7 6.9 23 5.6 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat PDEase_I_N PF08499.12 EFA79471.1 - 0.075 12.9 0.3 7.5 6.5 0.0 3.9 2 1 3 5 5 5 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal NleF_casp_inhib PF16809.5 EFA79471.1 - 0.097 12.6 9.4 39 4.1 0.1 6.1 3 2 4 7 7 7 0 NleF caspase inhibitor Anth_Ig PF05587.13 EFA79471.1 - 0.51 10.7 7.2 38 4.7 0.0 5.9 8 0 0 8 8 8 0 Anthrax receptor extracellular domain MF_alpha PF04648.12 EFA79471.1 - 0.73 10.2 2.5 21 5.6 0.0 3.6 4 0 0 4 4 2 0 Yeast mating factor alpha hormone DUF4988 PF16378.5 EFA79471.1 - 1.4 8.5 7.2 4.6 6.9 0.3 4.6 5 2 1 7 7 7 0 Domain of unknown function Ubiquitin_2 PF14560.6 EFA79471.1 - 2.8 8.5 6.2 71 4.0 0.0 4.4 3 1 2 5 5 5 0 Ubiquitin-like domain A_amylase_inhib PF01356.19 EFA79472.1 - 0.021 14.8 2.0 0.056 13.5 2.0 1.7 1 0 0 1 1 1 0 Alpha amylase inhibitor DUF5327 PF17261.2 EFA79473.1 - 0.0012 19.6 2.1 0.0036 18.0 2.1 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5327) Gemini_AL2 PF01440.16 EFA79473.1 - 0.18 12.3 4.2 0.44 11.0 4.2 1.6 1 0 0 1 1 1 0 Geminivirus AL2 protein ARD PF03079.14 EFA79474.1 - 3.8e-46 157.1 0.4 4.5e-46 156.9 0.4 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EFA79474.1 - 2.4e-11 43.2 0.0 4.6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EFA79474.1 - 3.2e-06 27.1 0.0 7.1e-06 26.0 0.0 1.5 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EFA79474.1 - 0.00068 19.3 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EFA79474.1 - 0.17 11.6 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF861) POP1 PF06978.11 EFA79475.1 - 1.3e-32 113.5 26.5 1.6e-18 67.4 6.1 3.5 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EFA79475.1 - 4.4e-26 91.0 0.8 3.3e-24 85.1 0.3 3.0 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T PF01571.21 EFA79475.1 - 3.9e-05 23.1 0.0 0.0062 15.9 0.0 2.4 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain Dicty_REP PF05086.12 EFA79475.1 - 0.17 9.8 9.6 0.3 9.0 9.6 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.13 EFA79475.1 - 2.1 6.6 11.9 0.51 8.6 3.1 2.2 2 0 0 2 2 2 0 Menin Mucin PF01456.17 EFA79475.1 - 2.2 8.3 19.4 4.6 7.2 19.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein EBP50_C PF09007.11 EFA79475.1 - 4.6 8.3 14.5 3.3 8.7 0.3 3.0 3 0 0 3 3 3 0 EBP50, C-terminal CHCH PF06747.13 EFA79476.1 - 0.00012 22.2 2.6 0.00039 20.5 2.8 1.8 1 1 1 2 2 2 1 CHCH domain MTCP1 PF08991.10 EFA79476.1 - 0.00034 20.8 2.2 0.00043 20.4 2.2 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CX9C PF16860.5 EFA79476.1 - 0.00047 20.1 2.0 0.00071 19.5 2.0 1.2 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EFA79476.1 - 0.039 14.0 2.5 0.055 13.5 2.5 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF1828 PF08861.10 EFA79476.1 - 0.047 14.0 0.0 0.065 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF1828 Ras PF00071.22 EFA79478.1 - 5.2e-57 192.0 0.1 6.3e-57 191.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA79478.1 - 8.7e-21 74.4 0.0 1.3e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA79478.1 - 4.4e-09 36.0 0.0 5.3e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA79478.1 - 8.3e-05 22.2 0.2 0.00028 20.5 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA79478.1 - 0.00095 19.2 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA79478.1 - 0.002 18.1 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EFA79478.1 - 0.0086 15.3 0.1 2.4 7.2 0.1 2.1 1 1 0 2 2 2 2 G-protein alpha subunit DUF2157 PF09925.9 EFA79478.1 - 0.072 12.9 0.1 0.41 10.4 0.1 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) CBFB_NFYA PF02045.15 EFA79480.1 - 2e-25 89.1 8.5 4.5e-25 88.0 8.5 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B SOG2 PF10428.9 EFA79480.1 - 0.77 8.9 17.4 0.88 8.7 17.4 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Pox_Ag35 PF03286.14 EFA79481.1 - 0.0059 16.4 8.6 0.009 15.8 8.6 1.3 1 0 0 1 1 1 1 Pox virus Ag35 surface protein CDC45 PF02724.14 EFA79481.1 - 0.0091 14.3 8.9 0.01 14.2 8.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 EFA79481.1 - 0.089 11.0 9.2 0.095 10.9 9.2 1.1 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 EFA79481.1 - 0.79 8.9 4.8 0.88 8.7 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Conotoxin PF02950.17 EFA79481.1 - 1.6 9.8 4.0 4.1 8.5 4.0 1.8 1 0 0 1 1 1 0 Conotoxin PBP1_TM PF14812.6 EFA79481.1 - 1.9 8.9 6.1 4.5 7.7 6.1 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Presenilin PF01080.17 EFA79481.1 - 3.6 6.2 6.9 4.3 6.0 6.9 1.1 1 0 0 1 1 1 0 Presenilin Med13_C PF06333.12 EFA79482.1 - 1.1e-22 80.8 0.3 1.8e-17 63.6 0.0 10.1 7 3 2 10 10 10 2 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 EFA79482.1 - 8.9e-16 58.4 10.5 8.9e-16 58.4 10.5 9.9 5 4 2 7 7 7 2 MID domain of medPIWI DUF641 PF04859.12 EFA79483.1 - 0.0053 17.1 0.9 0.0069 16.7 0.9 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) Sld5 PF05916.11 EFA79483.1 - 0.029 14.8 1.0 0.048 14.1 1.0 1.5 1 1 0 1 1 1 0 GINS complex protein RCC1 PF00415.18 EFA79484.1 - 5.2e-63 209.5 9.2 1.7e-13 51.0 0.0 6.9 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA79484.1 - 6.2e-35 118.3 31.8 1.1e-06 28.3 1.2 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFA79484.1 - 5e-23 81.5 1.9 7.7e-15 55.1 0.2 2.7 2 0 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.7 EFA79484.1 - 7.3e-09 36.1 0.2 3.2e-06 27.6 0.2 3.1 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79484.1 - 2.8e-06 27.5 0.6 7.6e-05 22.9 0.2 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79484.1 - 9.5e-06 26.1 0.1 4.1e-05 24.0 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79484.1 - 0.00019 21.6 0.1 0.089 13.4 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFA79484.1 - 0.00098 19.5 0.2 0.22 12.0 0.1 3.4 2 1 1 3 3 3 1 Ankyrin repeat Proteasome PF00227.26 EFA79485.1 - 9.5e-24 83.9 0.1 1.6e-23 83.2 0.1 1.4 1 1 0 1 1 1 1 Proteasome subunit Ribosomal_L29 PF00831.23 EFA79486.1 - 0.0043 17.0 0.2 0.0069 16.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal L29 protein Cep57_MT_bd PF06657.13 EFA79486.1 - 0.027 14.9 0.1 0.055 13.9 0.1 1.4 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF2034 PF10356.9 EFA79487.1 - 1.5e-12 47.3 7.7 8e-12 45.0 1.3 3.7 2 2 1 3 3 3 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EFA79487.1 - 2e-08 34.2 0.0 6.1e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Restriction endonuclease FAD_binding_1 PF00667.20 EFA79488.1 - 9.5e-36 123.4 0.2 4.9e-35 121.1 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 EFA79488.1 - 3.6e-18 66.2 0.0 8e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain GGDEF PF00990.21 EFA79490.1 - 4.2e-30 104.6 0.0 7.5e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Lipase_GDSL_lke PF16255.5 EFA79490.1 - 0.015 14.7 0.2 2.3 7.5 0.0 2.5 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase TMEMspv1-c74-12 PF11044.8 EFA79490.1 - 0.037 14.0 0.1 0.037 14.0 0.1 2.2 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein RecO_N_2 PF13114.6 EFA79490.1 - 0.043 13.5 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 RecO N terminal UvrA_DNA-bind PF17755.1 EFA79490.1 - 0.089 13.2 0.1 0.24 11.8 0.1 1.7 1 0 0 1 1 1 0 UvrA DNA-binding domain TK PF00265.18 EFA79491.1 - 1e-58 198.1 0.1 1.2e-58 197.9 0.1 1.0 1 0 0 1 1 1 1 Thymidine kinase ATPase_2 PF01637.18 EFA79491.1 - 0.019 14.9 0.1 0.028 14.3 0.1 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Pkinase_Tyr PF07714.17 EFA79492.1 - 1.8e-59 201.1 0.0 2.5e-59 200.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA79492.1 - 4.3e-46 157.4 0.0 7.1e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain LIM PF00412.22 EFA79492.1 - 3.8e-19 68.7 17.5 3.9e-10 39.8 5.2 2.5 2 0 0 2 2 2 2 LIM domain Pkinase_fungal PF17667.1 EFA79492.1 - 2.2e-05 23.5 0.0 3.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase LRR_6 PF13516.6 EFA79492.1 - 0.00031 20.5 11.3 0.13 12.4 1.5 4.4 4 0 0 4 4 3 2 Leucine Rich repeat APH PF01636.23 EFA79492.1 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family F-box-like PF12937.7 EFA79492.1 - 0.0017 18.2 0.1 0.0051 16.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like Kinase-like PF14531.6 EFA79492.1 - 0.0068 15.8 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFA79492.1 - 0.024 14.2 0.4 0.54 9.8 0.0 2.8 3 0 0 3 3 3 0 RIO1 family FTA2 PF13095.6 EFA79492.1 - 0.025 14.2 0.2 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFA79492.1 - 0.074 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RecG_N PF17190.4 EFA79492.1 - 0.13 13.0 0.1 0.37 11.5 0.1 1.8 1 0 0 1 1 1 0 RecG N-terminal helical domain F-box PF00646.33 EFA79492.1 - 0.6 10.1 5.4 4.8 7.2 0.5 2.7 2 0 0 2 2 2 0 F-box domain zf-FPG_IleRS PF06827.14 EFA79492.1 - 6.2 6.8 8.5 5.8 6.9 0.1 3.9 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS Zn_Tnp_IS1595 PF12760.7 EFA79492.1 - 9.3 6.3 10.3 2.5 8.2 1.9 2.9 2 1 0 2 2 2 0 Transposase zinc-ribbon domain WD40 PF00400.32 EFA79493.1 - 5.2e-28 96.7 5.9 5.2e-09 36.6 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA79493.1 - 7.5e-07 29.4 0.0 0.32 11.3 0.0 4.8 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA79493.1 - 0.00042 20.2 0.0 0.092 12.6 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFA79493.1 - 0.00062 19.2 0.0 1.4 8.2 0.0 2.8 2 1 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 EFA79493.1 - 0.0075 15.3 0.0 0.21 10.5 0.0 3.0 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein FAM53 PF15242.6 EFA79494.1 - 0.067 13.0 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Family of FAM53 Reovirus_cap PF00979.17 EFA79495.1 - 0.1 11.8 0.9 0.13 11.5 0.2 1.5 1 1 1 2 2 2 0 Reovirus outer capsid protein, Sigma 3 TRAM_LAG1_CLN8 PF03798.16 EFA79496.1 - 5.6e-34 117.6 14.9 7.2e-34 117.3 14.9 1.1 1 0 0 1 1 1 1 TLC domain DUF4834 PF16118.5 EFA79496.1 - 0.0065 17.4 0.2 0.012 16.6 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) K1 PF02960.14 EFA79496.1 - 0.034 14.3 0.1 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 K1 glycoprotein Methyltransf_28 PF02636.17 EFA79497.1 - 8.1e-68 228.9 0.0 1.2e-67 228.3 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PI31_Prot_N PF11566.8 EFA79498.1 - 1.2e-19 70.8 0.0 1.6e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EFA79498.1 - 6.8e-13 49.6 13.0 6.8e-13 49.6 13.0 2.9 3 1 0 3 3 3 1 PI31 proteasome regulator DUF3446 PF11928.8 EFA79498.1 - 0.48 10.8 4.7 0.64 10.4 2.1 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain ABC2_membrane_3 PF12698.7 EFA79499.1 - 1.6e-55 188.7 50.5 1.1e-28 100.3 23.9 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 EFA79499.1 - 3.8e-51 173.2 0.0 1.7e-25 90.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFA79499.1 - 2.1e-16 60.6 0.1 4.1e-06 26.8 0.0 4.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA79499.1 - 0.00042 19.8 0.0 4.7 6.6 0.0 3.5 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EFA79499.1 - 0.00075 19.5 0.0 2.9 7.8 0.0 3.5 3 0 0 3 3 3 1 Rad17 P-loop domain ABC2_membrane PF01061.24 EFA79499.1 - 0.001 18.5 36.4 0.015 14.8 14.3 3.2 3 0 0 3 3 3 2 ABC-2 type transporter SRP54 PF00448.22 EFA79499.1 - 0.0093 15.6 1.4 1.8 8.1 0.1 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 EFA79499.1 - 0.035 14.4 0.0 1.7 9.0 0.0 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EFA79499.1 - 0.043 13.7 1.1 0.98 9.3 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 EFA79499.1 - 0.05 13.3 4.2 4.2 7.0 0.0 3.8 4 0 0 4 4 4 0 AAA ATPase domain AAA_30 PF13604.6 EFA79499.1 - 0.076 12.7 0.1 7.8 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFA79499.1 - 0.087 12.6 0.1 0.087 12.6 0.1 3.0 3 0 0 3 3 2 0 P-loop containing region of AAA domain MukB PF04310.12 EFA79499.1 - 0.11 12.3 1.7 4 7.2 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal YcaO_C PF18381.1 EFA79499.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 YcaO cyclodehydratase C-terminal domain AAA_23 PF13476.6 EFA79499.1 - 0.2 12.2 8.8 1.6 9.2 0.2 3.0 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFA79500.1 - 1.5e-49 168.1 0.2 3.7e-25 89.0 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EFA79500.1 - 2e-48 165.3 57.6 4.9e-25 88.4 25.0 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EFA79500.1 - 2.8e-16 60.2 0.1 1.2e-05 25.3 0.0 4.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane PF01061.24 EFA79500.1 - 4.4e-05 23.0 13.2 4.4e-05 23.0 13.2 3.5 4 0 0 4 4 4 1 ABC-2 type transporter SMC_N PF02463.19 EFA79500.1 - 0.00021 20.8 0.0 1.8 7.9 0.0 3.6 2 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EFA79500.1 - 0.00089 19.2 0.0 0.45 10.4 0.0 2.7 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_29 PF13555.6 EFA79500.1 - 0.0015 18.2 2.6 0.1 12.4 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFA79500.1 - 0.0018 18.9 2.3 0.84 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 EFA79500.1 - 0.0047 16.6 2.0 0.74 9.4 0.2 2.6 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_15 PF13175.6 EFA79500.1 - 0.008 15.9 0.1 7.2 6.2 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.6 EFA79500.1 - 0.0097 16.1 0.0 2 8.7 0.1 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EFA79500.1 - 0.014 15.3 1.3 0.54 10.2 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_27 PF13514.6 EFA79500.1 - 0.11 12.1 0.2 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4162 PF13732.6 EFA79500.1 - 0.16 12.7 0.5 1.4 9.6 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_30 PF13604.6 EFA79500.1 - 0.24 11.1 0.7 25 4.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 EFA79500.1 - 0.87 9.6 3.2 14 5.7 1.1 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain ROK PF00480.20 EFA79501.1 - 3.9e-50 171.0 0.0 4.9e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 ROK family SAM_3 PF18016.1 EFA79501.1 - 0.079 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) TBCC PF07986.12 EFA79502.1 - 3.5e-22 78.4 15.8 2.7e-11 43.3 1.1 2.5 1 1 1 2 2 2 2 Tubulin binding cofactor C UME PF08064.13 EFA79502.1 - 0.13 12.2 1.0 13 5.7 0.0 2.8 3 0 0 3 3 3 0 UME (NUC010) domain adh_short PF00106.25 EFA79503.1 - 1.5e-51 174.6 0.0 2.1e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA79503.1 - 3.5e-37 128.2 0.0 4.6e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA79503.1 - 1.5e-07 31.5 0.0 2.5e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA79503.1 - 7.4e-06 25.6 0.1 3.6e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA79503.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain WD40 PF00400.32 EFA79504.1 - 2.1e-50 167.6 26.7 1.4e-06 28.9 0.1 10.4 10 0 0 10 10 10 9 WD domain, G-beta repeat Utp13 PF08625.11 EFA79504.1 - 7.5e-40 136.1 0.8 1.5e-39 135.1 0.8 1.5 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EFA79504.1 - 2.9e-16 59.5 10.3 0.00014 22.0 0.1 7.3 2 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA79504.1 - 7.9e-08 31.4 18.2 0.0027 16.4 0.1 7.1 2 2 5 7 7 7 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EFA79504.1 - 9.6e-05 22.4 6.3 4.1 7.5 0.0 6.6 6 2 0 6 6 6 1 Ciliary BBSome complex subunit 2, middle region UTP15_C PF09384.10 EFA79504.1 - 0.00098 18.8 0.8 0.002 17.8 0.8 1.4 1 0 0 1 1 1 1 UTP15 C terminal NUP214 PF16755.5 EFA79504.1 - 0.0022 17.3 2.3 0.0022 17.3 2.3 4.2 4 1 1 5 5 5 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Mcl1_mid PF12341.8 EFA79504.1 - 0.0043 16.4 0.3 1.6 8.0 0.0 2.7 2 1 0 2 2 2 2 Minichromosome loss protein, Mcl1, middle region CDC45 PF02724.14 EFA79504.1 - 0.0088 14.4 11.4 0.0071 14.7 2.7 2.4 3 0 0 3 3 3 2 CDC45-like protein Pox_TAP PF03355.14 EFA79504.1 - 0.03 13.9 1.7 0.36 10.4 0.1 3.0 1 1 0 2 2 2 0 Viral Trans-Activator Protein Dimer_Tnp_hAT PF05699.14 EFA79505.1 - 1.7e-10 40.6 0.3 6.2e-10 38.7 0.3 2.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region V_ATPase_I PF01496.19 EFA79506.1 - 0.00021 19.4 11.5 0.00025 19.1 11.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family EOS1 PF12326.8 EFA79506.1 - 0.0022 18.0 4.8 0.0027 17.7 4.8 1.0 1 0 0 1 1 1 1 N-glycosylation protein CDC45 PF02724.14 EFA79506.1 - 0.0027 16.1 13.4 0.0031 15.9 13.4 1.0 1 0 0 1 1 1 1 CDC45-like protein Connexin PF00029.19 EFA79506.1 - 0.038 13.7 10.1 0.041 13.6 10.1 1.1 1 0 0 1 1 1 0 Connexin Spt20 PF12090.8 EFA79506.1 - 0.04 13.5 18.6 0.041 13.5 18.6 1.1 1 0 0 1 1 1 0 Spt20 family Serinc PF03348.15 EFA79506.1 - 0.064 12.2 6.1 0.07 12.0 6.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Scs3p PF10261.9 EFA79506.1 - 0.081 12.4 0.5 0.093 12.2 0.5 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Tim54 PF11711.8 EFA79506.1 - 0.088 11.6 14.0 0.098 11.4 14.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Afi1 PF07792.12 EFA79506.1 - 0.11 13.0 14.2 0.13 12.7 14.2 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NUFIP2 PF15293.6 EFA79506.1 - 0.14 11.0 11.9 0.14 11.0 11.9 1.0 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 Vfa1 PF08432.10 EFA79506.1 - 0.17 12.2 24.0 0.19 12.0 24.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EFA79506.1 - 0.19 11.5 17.5 0.2 11.4 17.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 EFA79506.1 - 0.2 9.7 13.2 0.19 9.8 13.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FemAB PF02388.16 EFA79506.1 - 0.24 10.2 13.2 0.29 9.9 13.2 1.0 1 0 0 1 1 1 0 FemAB family DUF913 PF06025.12 EFA79506.1 - 0.26 10.2 8.1 0.28 10.1 8.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TRAP_alpha PF03896.16 EFA79506.1 - 0.28 10.4 6.9 0.31 10.2 6.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PARP PF00644.20 EFA79506.1 - 0.29 10.7 8.8 0.34 10.5 8.8 1.1 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain MscS_TM PF12794.7 EFA79506.1 - 0.33 9.8 4.2 0.4 9.5 4.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Kei1 PF08552.11 EFA79506.1 - 0.33 10.8 1.8 0.39 10.6 1.8 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CSG2 PF16965.5 EFA79506.1 - 0.36 9.7 7.0 0.41 9.6 7.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PIEZO PF15917.5 EFA79506.1 - 0.36 10.3 17.9 0.4 10.1 17.9 1.1 1 0 0 1 1 1 0 Piezo CLN3 PF02487.17 EFA79506.1 - 0.41 9.7 8.9 0.45 9.5 8.9 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2370 PF10176.9 EFA79506.1 - 0.46 10.1 4.6 0.5 10.0 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Presenilin PF01080.17 EFA79506.1 - 0.53 9.0 13.8 0.54 9.0 13.8 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 EFA79506.1 - 0.7 8.6 3.4 0.75 8.6 3.4 1.0 1 0 0 1 1 1 0 HCO3- transporter family Zip PF02535.22 EFA79506.1 - 0.76 8.9 8.5 0.82 8.8 8.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RPOL_N PF14700.6 EFA79506.1 - 0.85 9.0 14.5 0.92 8.8 14.5 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal CPSF100_C PF13299.6 EFA79506.1 - 0.87 9.7 12.7 1.1 9.4 12.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal AIF_C PF14721.6 EFA79506.1 - 1 9.7 9.9 1.4 9.3 9.9 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RPN2_C PF18004.1 EFA79506.1 - 1.1 9.2 24.4 1.2 9.1 24.4 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RP-C_C PF11800.8 EFA79506.1 - 1.1 9.3 7.5 1.3 9.1 7.5 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region GNAT_acetyltr_2 PF13718.6 EFA79506.1 - 1.3 8.3 7.9 1.6 8.0 7.9 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 SLC12 PF03522.15 EFA79506.1 - 1.4 7.9 15.6 1.4 7.9 15.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SpoIIP PF07454.11 EFA79506.1 - 1.6 8.1 17.3 1.7 8.0 17.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) MCM_bind PF09739.9 EFA79506.1 - 1.9 6.9 16.1 2 6.8 16.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rad54_N PF08658.10 EFA79506.1 - 1.9 8.6 17.9 2.3 8.4 17.9 1.0 1 0 0 1 1 1 0 Rad54 N terminal DDHD PF02862.17 EFA79506.1 - 2.1 8.4 10.1 2.4 8.3 10.1 1.1 1 0 0 1 1 1 0 DDHD domain EMC3_TMCO1 PF01956.16 EFA79506.1 - 2.3 7.9 9.9 2.9 7.6 9.9 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF2126 PF09899.9 EFA79506.1 - 2.4 6.1 7.6 2.5 6.0 7.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SID-1_RNA_chan PF13965.6 EFA79506.1 - 2.4 6.5 8.9 2.6 6.3 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RPA43_OB PF17875.1 EFA79506.1 - 2.4 8.8 11.0 3.4 8.3 11.0 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I FAM60A PF15396.6 EFA79506.1 - 2.8 7.9 16.3 3 7.8 16.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF789 PF05623.12 EFA79506.1 - 3 7.5 10.6 3.3 7.3 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) ALMT PF11744.8 EFA79506.1 - 3 6.6 10.9 3.1 6.5 10.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PPL5 PF18168.1 EFA79506.1 - 3.2 6.9 13.7 3.7 6.8 13.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 OATP PF03137.20 EFA79506.1 - 3.3 5.9 6.9 3.3 5.9 6.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family NPR3 PF03666.13 EFA79506.1 - 3.4 6.4 17.9 3.7 6.2 17.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Otopetrin PF03189.13 EFA79506.1 - 3.5 6.3 5.3 3.8 6.2 5.3 1.0 1 0 0 1 1 1 0 Otopetrin TFB6 PF17110.5 EFA79506.1 - 3.6 7.3 11.9 5.1 6.8 11.9 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Neur_chan_memb PF02932.16 EFA79506.1 - 3.7 7.5 8.5 3.8 7.5 8.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RNA_pol_Rpc4 PF05132.14 EFA79506.1 - 4 7.9 15.9 5 7.5 15.9 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ctr PF04145.15 EFA79506.1 - 4.1 8.0 4.7 4.8 7.8 4.7 1.2 1 0 0 1 1 1 0 Ctr copper transporter family LMBR1 PF04791.16 EFA79506.1 - 5 5.9 10.3 5.8 5.7 10.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RNA_polI_A34 PF08208.11 EFA79506.1 - 5 7.2 26.5 6.2 6.9 26.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4820 PF16091.5 EFA79506.1 - 5.9 6.2 13.4 7.1 5.9 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Membralin PF09746.9 EFA79506.1 - 6.4 5.7 10.3 7.1 5.6 10.3 1.0 1 0 0 1 1 1 0 Tumour-associated protein Ank_2 PF12796.7 EFA79507.1 - 8.1e-19 68.0 15.1 4.7e-06 27.1 2.2 4.9 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79507.1 - 2.9e-18 66.0 14.9 1.2e-06 29.0 0.3 6.4 5 1 0 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79507.1 - 1e-11 44.0 11.3 0.61 10.8 0.0 10.0 8 3 3 11 11 11 2 Ankyrin repeat Ank_5 PF13857.6 EFA79507.1 - 1.7e-10 40.9 10.1 0.018 15.4 0.2 7.6 2 1 6 8 8 8 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA79507.1 - 0.0061 17.0 9.2 4.9 7.8 0.4 7.0 4 1 3 7 7 7 1 Ankyrin repeat FaeA PF04703.12 EFA79507.1 - 0.11 12.9 0.2 0.58 10.6 0.1 2.3 2 1 0 2 2 2 0 FaeA-like protein FBD PF08387.10 EFA79507.1 - 1.1 9.2 3.9 52 3.8 0.0 4.0 4 0 0 4 4 4 0 FBD 2OG-FeII_Oxy PF03171.20 EFA79508.1 - 2.1e-18 66.6 0.1 4.5e-18 65.6 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFA79508.1 - 2.4e-14 54.1 3.6 2.5e-13 50.8 2.1 3.0 2 1 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal ABC2_membrane PF01061.24 EFA79509.1 - 6.1e-88 293.7 63.5 3.1e-48 164.0 26.3 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EFA79509.1 - 1.5e-38 132.4 0.0 3.1e-19 69.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFA79509.1 - 1.6e-24 85.6 15.3 1.3e-21 76.3 0.1 3.6 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EFA79509.1 - 5.7e-12 45.4 52.6 1.7e-08 34.0 16.9 3.4 2 1 1 3 3 3 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 EFA79509.1 - 9.2e-10 39.0 0.0 2e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EFA79509.1 - 2.9e-07 30.5 0.1 0.00014 21.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EFA79509.1 - 2e-05 24.2 0.4 0.0045 16.7 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA79509.1 - 0.00011 22.7 0.0 0.2 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFA79509.1 - 0.00011 22.1 0.0 0.29 10.9 0.0 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EFA79509.1 - 0.001 18.7 0.1 0.0048 16.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA79509.1 - 0.0028 18.2 0.0 0.46 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFA79509.1 - 0.0041 17.4 0.1 1.4 9.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFA79509.1 - 0.0066 16.6 0.0 0.5 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFA79509.1 - 0.022 14.8 0.4 9.5 6.3 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EFA79509.1 - 0.041 13.6 0.2 3.9 7.1 0.5 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFA79509.1 - 0.074 13.0 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain Zeta_toxin PF06414.12 EFA79509.1 - 0.099 11.9 0.2 7 5.9 0.3 2.3 2 0 0 2 2 2 0 Zeta toxin cobW PF02492.19 EFA79509.1 - 0.18 11.4 1.4 1.1 8.8 0.4 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF2399 PF09664.10 EFA79509.1 - 0.19 11.6 0.0 2.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2399) RNA_helicase PF00910.22 EFA79509.1 - 0.21 12.0 0.6 30 5.0 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_28 PF13521.6 EFA79509.1 - 0.42 10.8 1.8 1.1 9.5 0.6 2.1 2 0 0 2 2 2 0 AAA domain TPR_2 PF07719.17 EFA79510.1 - 1.4e-06 28.0 4.2 0.63 10.3 0.0 6.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA79510.1 - 3.3e-06 26.7 4.0 0.43 10.5 0.0 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA79510.1 - 7.4e-05 23.0 0.2 19 5.6 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA79510.1 - 8.5e-05 22.5 3.8 2.3 8.7 0.0 6.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA79510.1 - 0.055 14.0 2.6 42 4.7 0.0 4.5 5 1 1 6 6 6 0 Tetratricopeptide repeat Pex14_N PF04695.13 EFA79510.1 - 7.1 7.3 28.7 4.3 8.0 0.8 4.4 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1206 PF06724.11 EFA79512.1 - 2.3e-08 34.0 41.3 1.6e-05 24.9 2.7 4.5 4 0 0 4 4 4 3 Domain of Unknown Function (DUF1206) Tetraspanin PF00335.20 EFA79512.1 - 1.3 8.7 7.1 2.4 7.8 1.8 2.5 2 0 0 2 2 2 0 Tetraspanin family ATG101 PF07855.12 EFA79513.1 - 6.2e-35 120.5 3.7 7.7e-35 120.2 3.7 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 PsbP PF01789.16 EFA79515.1 - 1.1e-05 25.6 5.2 0.0008 19.6 0.5 3.2 2 1 0 2 2 2 2 PsbP YEATS PF03366.16 EFA79517.1 - 1.9e-26 91.8 0.4 5.7e-26 90.3 0.4 1.8 1 0 0 1 1 1 1 YEATS family Androgen_recep PF02166.16 EFA79517.1 - 6.3 5.5 13.2 20 3.9 13.2 1.8 1 0 0 1 1 1 0 Androgen receptor Q_salvage PF10343.9 EFA79518.1 - 6.3e-86 288.4 0.0 8.7e-86 288.0 0.0 1.2 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 EFA79518.1 - 8.3e-05 21.5 0.1 0.0073 15.1 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1688) Paf67 PF10255.9 EFA79519.1 - 1.1e-125 419.8 8.9 1.1e-125 419.8 8.9 1.5 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 PCI PF01399.27 EFA79519.1 - 0.00087 19.8 0.3 0.0029 18.1 0.3 1.9 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 EFA79519.1 - 0.041 14.0 1.1 0.041 14.0 1.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA79519.1 - 0.051 14.1 6.7 0.14 12.7 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Lin-8 PF03353.15 EFA79519.1 - 4 6.9 17.6 85 2.6 0.0 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PCI PF01399.27 EFA79520.1 - 3.7e-08 33.8 0.1 3.7e-08 33.8 0.1 2.7 3 0 0 3 3 3 1 PCI domain Cyclin_N PF00134.23 EFA79521.1 - 0.00028 20.6 0.3 0.00028 20.6 0.3 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 EFA79521.1 - 0.0056 17.1 14.3 0.045 14.1 14.2 2.6 1 1 0 1 1 1 1 Cyclin Arm PF00514.23 EFA79523.1 - 3.3e-32 109.5 13.8 0.00027 20.9 0.0 11.4 11 0 0 11 11 11 7 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EFA79523.1 - 1.9e-17 61.9 13.0 0.53 10.7 0.2 10.7 11 0 0 11 11 11 5 HEAT repeat HEAT_2 PF13646.6 EFA79523.1 - 2.8e-15 56.5 1.3 0.00058 20.2 0.0 6.2 3 2 2 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 EFA79523.1 - 1e-09 38.7 10.5 0.0042 17.6 0.5 7.2 7 2 2 9 9 9 2 HEAT-like repeat V-ATPase_H_C PF11698.8 EFA79523.1 - 2.2e-07 31.0 7.6 0.41 10.8 0.1 5.9 3 3 4 7 7 7 4 V-ATPase subunit H Cnd1 PF12717.7 EFA79523.1 - 7.9e-06 26.0 8.4 0.49 10.4 0.0 5.1 2 1 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EFA79523.1 - 9.8e-05 22.5 4.8 1.1 9.5 0.0 4.6 5 0 0 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EFA79523.1 - 0.00019 21.0 9.0 0.008 15.8 0.2 3.8 4 2 0 4 4 4 2 CLASP N terminal Atx10homo_assoc PF09759.9 EFA79523.1 - 0.00032 20.7 12.6 0.022 14.8 0.6 5.8 6 2 1 7 7 7 2 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.8 EFA79523.1 - 0.012 15.6 14.0 0.037 14.0 0.5 4.6 3 2 1 4 4 4 0 Domain of unknown function (DUF3361) DUF5584 PF17822.1 EFA79523.1 - 0.031 13.8 0.7 1.1 8.7 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5584) RasGEF_N_2 PF14663.6 EFA79523.1 - 0.11 12.9 3.6 20 5.6 0.1 5.0 5 1 1 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain AA_kinase PF00696.28 EFA79524.1 - 3.7e-24 85.7 0.1 7.9e-24 84.6 0.1 1.5 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dh PF01118.24 EFA79524.1 - 3.2e-22 79.2 0.0 9.9e-22 77.6 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAT PF04768.13 EFA79524.1 - 4.3e-13 49.3 0.0 1.1e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Sacchrp_dh_NADP PF03435.18 EFA79524.1 - 0.11 12.7 0.0 14 6.0 0.0 2.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain PPR PF01535.20 EFA79525.1 - 1.7e-23 81.2 10.8 0.00012 22.1 0.0 6.7 8 0 0 8 8 8 4 PPR repeat PPR_2 PF13041.6 EFA79525.1 - 2.5e-23 82.0 5.5 1.3e-06 28.5 0.0 5.4 4 2 3 7 7 7 5 PPR repeat family PPR_1 PF12854.7 EFA79525.1 - 9.1e-20 70.1 2.7 6.3e-07 29.0 0.0 4.9 4 0 0 4 4 4 4 PPR repeat PPR_3 PF13812.6 EFA79525.1 - 3.8e-13 49.3 0.3 0.00033 20.7 0.0 4.6 3 1 1 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 EFA79525.1 - 0.00012 21.5 1.5 0.15 11.4 0.2 3.9 3 1 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EFA79525.1 - 0.0017 18.2 1.7 0.46 10.3 0.1 4.1 4 1 0 4 4 4 1 Mitochondrial ATPase expression TPR_14 PF13428.6 EFA79525.1 - 0.0073 17.0 0.0 27 5.9 0.0 4.2 4 1 1 5 5 4 0 Tetratricopeptide repeat Dynein_AAA_lid PF17852.1 EFA79525.1 - 0.12 12.4 2.8 0.26 11.4 1.2 2.4 3 0 0 3 3 3 0 Dynein heavy chain AAA lid domain RPA_interact_C PF14768.6 EFA79525.1 - 1.5 9.5 4.5 8.5 7.0 4.5 2.4 1 1 0 1 1 1 0 Replication protein A interacting C-terminal U1snRNP70_N PF12220.8 EFA79525.1 - 8.1 7.2 9.5 3.1 8.5 1.6 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal dsRBD2 PF17842.1 EFA79525.1 - 9.3 6.4 13.2 0.64 10.2 1.9 3.2 3 0 0 3 3 3 0 Double-stranded RNA binding domain 2 RasGAP PF00616.19 EFA79526.1 - 6.7e-57 192.5 2.2 6.7e-57 192.5 2.2 2.7 2 1 1 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFA79526.1 - 4.1e-25 88.5 12.4 4.1e-25 88.5 12.4 2.5 3 0 0 3 3 3 1 RasGAP C-terminus Peptidase_S49_N PF08496.10 EFA79526.1 - 0.17 11.9 5.2 0.61 10.2 5.2 2.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MitMem_reg PF13012.6 EFA79526.1 - 0.47 10.9 7.4 1.2 9.6 0.5 3.6 4 1 0 4 4 4 0 Maintenance of mitochondrial structure and function Latarcin PF10279.9 EFA79526.1 - 2 8.9 8.9 1.5 9.3 2.3 3.1 3 0 0 3 3 3 0 Latarcin precursor zf-rbx1 PF12678.7 EFA79527.1 - 1.2e-24 86.4 12.6 1.8e-24 85.8 12.6 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFA79527.1 - 5.7e-16 58.3 10.1 7.7e-16 57.9 10.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFA79527.1 - 2.7e-06 27.6 9.1 2.7e-06 27.6 9.1 2.3 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA79527.1 - 6.6e-05 22.7 3.5 6.6e-05 22.7 3.5 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA79527.1 - 0.0013 18.6 12.5 0.032 14.1 12.5 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EFA79527.1 - 0.0076 15.9 3.3 0.0076 15.9 3.3 2.3 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EFA79527.1 - 0.23 11.6 9.2 2.1 8.6 9.5 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_11 PF17123.5 EFA79527.1 - 0.29 10.9 15.9 27 4.6 15.9 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EFA79527.1 - 0.49 10.5 8.2 1.9 8.6 8.2 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFA79527.1 - 3.2 7.7 12.9 17 5.4 0.3 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Actin PF00022.19 EFA79528.1 - 3.9e-41 141.0 0.0 9.2e-41 139.8 0.0 1.5 1 1 0 1 1 1 1 Actin Queuosine_synth PF02547.15 EFA79528.1 - 0.084 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein MreB_Mbl PF06723.13 EFA79528.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein Nod1 PF17114.5 EFA79528.1 - 3.9 7.6 10.5 7.2 6.8 1.6 3.3 3 0 0 3 3 3 0 Gef2-related medial cortical node protein Nod1 EF-hand_7 PF13499.6 EFA79529.1 - 5.8e-09 36.3 5.1 5.6e-08 33.1 0.4 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA79529.1 - 4.9e-07 29.2 3.1 1.5e-05 24.5 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EFA79529.1 - 8.4e-06 25.0 4.0 1.4e-05 24.3 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 EFA79529.1 - 0.0001 21.6 0.2 0.00027 20.3 0.2 1.7 1 0 0 1 1 1 1 EF hand EF_assoc_1 PF08355.12 EFA79529.1 - 0.013 15.1 0.3 0.028 14.0 0.3 1.5 1 0 0 1 1 1 0 EF hand associated EF-hand_8 PF13833.6 EFA79529.1 - 0.022 14.6 0.1 0.057 13.3 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF_assoc_2 PF08356.12 EFA79529.1 - 0.038 14.0 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 EF hand associated TraG-D_C PF12696.7 EFA79529.1 - 0.2 11.6 6.2 0.23 11.4 0.2 2.2 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG PhzC-PhzF PF02567.16 EFA79531.1 - 1.2e-52 179.2 0.0 1.3e-52 179.0 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 EFA79531.1 - 5.1e-07 29.1 0.0 1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Proline racemase SBD_N PF07005.11 EFA79531.1 - 0.17 11.6 0.0 15 5.3 0.0 2.2 2 0 0 2 2 2 0 Sugar-binding N-terminal domain Cation_efflux PF01545.21 EFA79532.1 - 1.7e-40 138.9 0.0 4e-40 137.7 0.0 1.6 2 0 0 2 2 2 1 Cation efflux family LRR_6 PF13516.6 EFA79533.1 - 1.1e-09 37.5 11.1 0.00024 20.9 0.2 4.6 4 0 0 4 4 4 3 Leucine Rich repeat Macoilin PF09726.9 EFA79533.1 - 0.00093 17.9 13.6 0.0011 17.7 13.6 1.1 1 0 0 1 1 1 1 Macoilin family Presenilin PF01080.17 EFA79533.1 - 0.014 14.2 9.4 0.018 13.8 9.4 1.1 1 0 0 1 1 1 0 Presenilin Smg8_Smg9 PF10220.9 EFA79533.1 - 0.033 12.5 4.3 0.04 12.2 4.3 1.0 1 0 0 1 1 1 0 Smg8_Smg9 MMU163 PF17119.5 EFA79533.1 - 0.059 12.5 3.9 0.1 11.8 3.9 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Zip PF02535.22 EFA79533.1 - 0.072 12.3 0.9 0.077 12.2 0.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 EFA79533.1 - 0.84 8.4 11.7 1.3 7.7 11.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3807 PF12720.7 EFA79533.1 - 3.3 8.0 13.2 4.9 7.4 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) ALMT PF11744.8 EFA79533.1 - 4.4 6.0 10.5 5.8 5.6 10.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3113 PF11310.8 EFA79534.1 - 0.052 13.5 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) Dicty_CTDC PF00526.18 EFA79535.1 - 2.3e-212 686.0 527.1 2.9e-11 43.0 15.3 27.2 27 0 0 27 27 27 27 Dictyostelium (slime mold) repeat RNase_P_Rpp14 PF01900.19 EFA79536.1 - 5.9e-13 48.9 0.1 1.3e-12 47.8 0.0 1.6 1 1 1 2 2 2 1 Rpp14/Pop5 family Ran_BP1 PF00638.18 EFA79537.1 - 1.2e-15 57.8 1.0 1.2e-15 57.8 1.0 1.9 2 0 0 2 2 2 1 RanBP1 domain HpcH_HpaI PF03328.14 EFA79538.1 - 2.9e-46 157.4 0.1 1.7e-45 154.9 0.1 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EFA79538.1 - 9.4e-18 64.5 0.0 1.4e-11 44.1 0.0 2.2 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PGK PF00162.19 EFA79539.1 - 6.7e-151 502.5 1.5 7.6e-151 502.3 1.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF3172 PF11371.8 EFA79539.1 - 0.14 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) Tim17 PF02466.19 EFA79540.1 - 2.3e-28 98.8 6.7 3e-28 98.4 5.9 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF4199 PF13858.6 EFA79540.1 - 0.0075 16.7 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) G0-G1_switch_2 PF15103.6 EFA79540.1 - 2.4 8.6 5.9 0.22 12.0 1.3 1.6 2 0 0 2 2 2 0 G0/G1 switch protein 2 CH PF00307.31 EFA79541.1 - 2.6e-77 256.0 6.9 5.7e-22 78.0 0.2 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.32 EFA79541.1 - 8.7e-13 46.8 1.1 9.8e-06 24.8 0.2 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFA79541.1 - 1.5e-11 44.6 0.2 7e-11 42.4 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.8 EFA79541.1 - 3.8e-11 42.7 0.3 0.00057 19.7 0.0 3.4 3 0 0 3 3 3 2 CAMSAP CH domain EF-hand_6 PF13405.6 EFA79541.1 - 4.1e-10 38.8 0.4 1.2e-05 24.9 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EFA79541.1 - 1.8e-08 33.5 2.6 3e-05 23.3 0.4 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFA79541.1 - 2.2e-06 27.4 0.4 0.00016 21.5 0.0 3.3 1 1 1 2 2 2 2 EF-hand domain pair CH_2 PF06294.11 EFA79541.1 - 0.018 15.1 0.0 0.27 11.4 0.0 2.7 3 0 0 3 3 3 0 CH-like domain in sperm protein EF-hand_9 PF14658.6 EFA79541.1 - 0.075 13.4 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain Actin PF00022.19 EFA79542.1 - 5.6e-62 209.7 0.0 2e-51 174.9 0.0 3.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFA79542.1 - 0.0085 15.0 0.0 0.027 13.3 0.0 1.7 1 1 0 1 1 1 1 MreB/Mbl protein p450 PF00067.22 EFA79543.1 - 4.1e-64 217.0 0.1 6.1e-64 216.5 0.1 1.2 1 0 0 1 1 1 1 Cytochrome P450 LRR_8 PF13855.6 EFA79545.1 - 0.0029 17.4 0.6 0.0051 16.5 0.6 1.4 1 0 0 1 1 1 1 Leucine rich repeat CMAS PF02353.20 EFA79547.1 - 5.4e-86 288.3 0.0 6.9e-86 287.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EFA79547.1 - 1.4e-11 44.9 0.0 2.8e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA79547.1 - 4.3e-11 43.4 0.0 1.1e-10 42.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA79547.1 - 8.4e-11 42.0 0.0 1.4e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA79547.1 - 2.6e-08 33.8 0.0 4.3e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA79547.1 - 5.4e-08 33.5 0.0 1.3e-07 32.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA79547.1 - 0.00025 20.6 0.0 0.00049 19.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_PK PF05891.12 EFA79547.1 - 0.00079 19.0 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_3 PF01596.17 EFA79547.1 - 0.0018 17.5 0.0 0.0031 16.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_2 PF00891.18 EFA79547.1 - 0.0066 15.8 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Cons_hypoth95 PF03602.15 EFA79547.1 - 0.0093 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DOT1 PF08123.13 EFA79547.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_18 PF12847.7 EFA79547.1 - 0.02 14.8 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EFA79547.1 - 0.047 12.8 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_24 PF13578.6 EFA79547.1 - 0.086 13.9 0.0 0.23 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Spermine_synth PF01564.17 EFA79547.1 - 0.097 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase domain PCMT PF01135.19 EFA79547.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EFA79547.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 EFA79547.1 - 0.15 11.8 0.0 1.7 8.4 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Amino_oxidase PF01593.24 EFA79548.1 - 3.2e-22 79.5 0.1 1.1e-20 74.4 0.1 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA79548.1 - 3.2e-16 59.3 0.2 7.6e-16 58.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA79548.1 - 3e-11 43.5 3.8 1.1e-07 31.8 0.9 2.9 2 2 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFA79548.1 - 2.1e-08 34.6 2.4 4.2e-05 24.0 0.2 2.7 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFA79548.1 - 4.8e-07 29.2 0.7 3.7e-06 26.3 0.7 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFA79548.1 - 1.2e-06 28.1 0.0 0.0015 17.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFA79548.1 - 9.2e-05 21.3 0.1 0.0049 15.6 0.3 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EFA79548.1 - 0.00095 18.6 0.3 0.0019 17.6 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFA79548.1 - 0.0011 19.0 0.3 0.46 10.5 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding MCRA PF06100.11 EFA79548.1 - 0.0011 17.8 3.6 0.048 12.4 3.6 2.7 1 1 0 1 1 1 1 MCRA family Pyr_redox_3 PF13738.6 EFA79548.1 - 0.002 17.5 0.3 0.22 10.7 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFA79548.1 - 0.0059 15.1 0.0 0.011 14.2 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Thi4 PF01946.17 EFA79548.1 - 0.0098 15.2 0.7 0.015 14.5 0.7 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 EFA79548.1 - 0.029 13.5 1.3 0.069 12.2 0.9 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFA79548.1 - 0.045 13.0 1.3 0.062 12.5 0.5 1.6 2 0 0 2 2 2 0 FAD binding domain 3HCDH_N PF02737.18 EFA79548.1 - 0.2 11.5 0.8 0.43 10.4 0.8 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SpoU_methylase PF00588.19 EFA79550.1 - 4.6e-28 98.2 0.0 1.1e-27 96.9 0.0 1.7 1 0 0 1 1 1 1 SpoU rRNA Methylase family SUIM_assoc PF16619.5 EFA79550.1 - 0.0056 16.7 0.0 0.056 13.5 0.0 2.6 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF1053 PF06327.14 EFA79550.1 - 0.068 13.7 2.6 28 5.3 0.0 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1053) Methyltrn_RNA_4 PF09936.9 EFA79550.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase Ogr_Delta PF04606.12 EFA79550.1 - 0.94 9.5 10.6 31 4.7 0.0 3.9 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger ECH_1 PF00378.20 EFA79551.1 - 6.7e-68 228.7 0.1 1e-67 228.1 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase AA_permease_2 PF13520.6 EFA79551.1 - 9.2e-34 117.0 33.4 1.9e-31 109.4 33.4 2.1 1 1 0 1 1 1 1 Amino acid permease ECH_2 PF16113.5 EFA79551.1 - 1.4e-31 110.3 0.1 2.2e-31 109.6 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase AA_permease PF00324.21 EFA79551.1 - 2.6e-18 65.9 26.2 2e-16 59.7 26.2 2.2 1 1 0 1 1 1 1 Amino acid permease PrpR_N PF06506.11 EFA79551.1 - 0.0014 18.3 0.2 0.0029 17.2 0.2 1.5 1 0 0 1 1 1 1 Propionate catabolism activator Phage_holin_3_6 PF07332.11 EFA79551.1 - 0.016 15.2 0.9 0.016 15.2 0.9 2.7 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4131 PF13567.6 EFA79551.1 - 0.76 9.4 2.7 1.3 8.6 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Blt1 PF12754.7 EFA79552.1 - 0.1 12.9 0.3 0.15 12.3 0.3 1.2 1 0 0 1 1 1 0 Blt1 N-terminal domain Alph_Pro_TM PF09608.10 EFA79553.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) HEAT PF02985.22 EFA79554.1 - 0.0083 16.3 0.0 0.42 11.0 0.0 3.3 2 0 0 2 2 2 1 HEAT repeat DSPc PF00782.20 EFA79555.1 - 5.4e-27 94.2 0.1 5.4e-27 94.2 0.1 3.0 4 0 0 4 4 4 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA79555.1 - 0.021 14.4 5.6 0.027 14.0 0.0 2.6 2 1 1 3 3 3 0 Protein-tyrosine phosphatase POX PF07526.11 EFA79555.1 - 0.081 13.5 2.7 0.22 12.1 2.7 1.7 1 0 0 1 1 1 0 Associated with HOX TFB6 PF17110.5 EFA79555.1 - 0.1 12.4 3.9 0.3 10.8 3.9 1.8 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PTPlike_phytase PF14566.6 EFA79555.1 - 0.25 11.4 4.4 2.5 8.2 0.0 3.2 2 1 0 2 2 2 0 Inositol hexakisphosphate FlaG PF03646.15 EFA79555.1 - 0.5 10.6 10.9 1.6 8.9 10.9 1.9 1 0 0 1 1 1 0 FlaG protein Presenilin PF01080.17 EFA79555.1 - 1 8.1 3.6 1.6 7.5 3.6 1.2 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 EFA79555.1 - 4.5 7.9 12.2 0.29 11.7 6.4 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain Peptidase_M24 PF00557.24 EFA79556.1 - 1.8e-50 171.5 0.0 2.3e-50 171.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 UPF0560 PF10577.9 EFA79556.1 - 0.032 12.7 1.4 0.043 12.3 1.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2341 PF10102.9 EFA79557.1 - 0.062 13.9 1.3 0.21 12.2 1.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF2341) Menin PF05053.13 EFA79558.1 - 0.04 12.3 4.1 0.047 12.1 4.1 1.1 1 0 0 1 1 1 0 Menin EST1 PF10374.9 EFA79558.1 - 0.07 13.8 0.7 0.11 13.2 0.7 1.3 1 0 0 1 1 1 0 Telomerase activating protein Est1 Presenilin PF01080.17 EFA79558.1 - 1 8.1 3.3 1.2 7.8 3.3 1.1 1 0 0 1 1 1 0 Presenilin DUF2956 PF11169.8 EFA79558.1 - 1.3 9.2 7.8 0.62 10.3 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) COX16 PF14138.6 EFA79560.1 - 0.00021 21.7 0.2 0.00042 20.8 0.2 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Comm PF15957.5 EFA79560.1 - 0.16 12.3 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Commissureless Menin PF05053.13 EFA79560.1 - 2.5 6.4 7.7 2.8 6.2 7.7 1.0 1 0 0 1 1 1 0 Menin Acetyltransf_CG PF14542.6 EFA79561.1 - 7.4e-23 80.5 0.0 9e-23 80.2 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.7 EFA79561.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NRDE-2 PF08424.10 EFA79562.1 - 1e-87 294.3 15.9 1e-87 294.3 15.9 3.9 4 1 0 4 4 4 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EFA79562.1 - 4.5e-07 30.2 0.9 8.7 7.5 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFA79562.1 - 0.0014 18.6 0.9 0.034 14.1 0.2 3.5 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 Thioredoxin_16 PF18569.1 EFA79562.1 - 0.069 13.3 0.9 0.32 11.1 0.9 2.1 1 0 0 1 1 1 0 Thioredoxin-like domain PKcGMP_CC PF16808.5 EFA79563.1 - 2.6e-13 49.6 53.4 0.0034 17.2 2.0 18.9 19 0 0 19 19 19 1 Coiled-coil N-terminus of cGMP-dependent protein kinase TolA_bind_tri PF16331.5 EFA79563.1 - 8.5e-10 38.6 141.3 0.0074 16.3 0.1 15.4 3 2 10 15 15 13 7 TolA binding protein trimerisation Myosin_tail_1 PF01576.19 EFA79563.1 - 3.3e-09 35.2 67.4 3.3e-09 35.2 67.4 5.1 1 1 4 5 5 5 1 Myosin tail Fez1 PF06818.15 EFA79563.1 - 3.9e-09 37.2 45.6 2.4e-05 24.9 8.8 9.0 1 1 8 9 9 7 4 Fez1 DUF4201 PF13870.6 EFA79563.1 - 4.8e-09 36.2 42.2 7.9e-06 25.7 8.8 8.8 2 1 6 8 8 6 5 Domain of unknown function (DUF4201) Filament PF00038.21 EFA79563.1 - 7.1e-08 32.4 149.7 0.00045 19.9 4.9 9.6 2 1 9 11 11 10 8 Intermediate filament protein HOOK PF05622.12 EFA79563.1 - 8.5e-08 30.8 60.5 2e-05 23.0 20.8 8.2 1 1 8 9 9 7 4 HOOK protein HALZ PF02183.18 EFA79563.1 - 4.2e-07 30.1 74.0 0.11 12.8 1.5 14.0 10 3 3 14 14 14 6 Homeobox associated leucine zipper Phage_GP20 PF06810.11 EFA79563.1 - 1.4e-06 28.2 184.4 0.0003 20.6 4.2 14.5 4 2 9 14 14 11 7 Phage minor structural protein GP20 WEMBL PF05701.11 EFA79563.1 - 2.2e-05 23.4 15.9 2.2e-05 23.4 15.9 6.9 1 1 6 7 7 5 2 Weak chloroplast movement under blue light Cast PF10174.9 EFA79563.1 - 3.7e-05 22.2 15.4 3.7e-05 22.2 15.4 4.9 1 1 2 4 4 3 2 RIM-binding protein of the cytomatrix active zone MAD PF05557.13 EFA79563.1 - 8.8e-05 21.1 15.1 8.8e-05 21.1 15.1 5.5 1 1 2 4 4 3 2 Mitotic checkpoint protein Golgin_A5 PF09787.9 EFA79563.1 - 0.00011 21.8 25.1 0.00011 21.8 25.1 8.2 1 1 6 9 9 9 5 Golgin subfamily A member 5 MscS_porin PF12795.7 EFA79563.1 - 0.00016 21.4 53.1 0.00049 19.7 28.4 8.1 3 1 4 7 7 6 3 Mechanosensitive ion channel porin domain DAHP_snth_FXD PF18152.1 EFA79563.1 - 0.00021 21.0 9.3 1.9 8.4 0.1 5.8 1 1 5 6 6 6 2 DAHP synthase ferredoxin-like domain Bap31_Bap29_C PF18035.1 EFA79563.1 - 0.00043 20.2 135.9 0.083 12.9 7.3 18.3 14 4 2 16 16 14 9 Bap31/Bap29 cytoplasmic coiled-coil domain HMMR_N PF15905.5 EFA79563.1 - 0.00058 19.4 26.2 0.00085 18.9 12.6 9.5 2 2 8 10 10 6 4 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.9 EFA79563.1 - 0.00062 19.8 165.6 0.022 14.8 6.7 11.1 2 1 11 13 13 12 6 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EFA79563.1 - 0.00093 19.5 16.8 0.0024 18.2 6.6 11.7 1 1 9 10 10 8 6 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 EFA79563.1 - 0.0014 16.3 24.0 0.0014 16.3 24.0 4.6 2 2 2 4 4 4 1 Protein of unknown function (DUF3584) DUF724 PF05266.14 EFA79563.1 - 0.0014 18.5 7.2 0.0014 18.5 7.2 10.5 4 2 8 12 12 9 5 Protein of unknown function (DUF724) DUF5082 PF16888.5 EFA79563.1 - 0.0018 18.6 12.3 0.0018 18.6 12.3 10.2 2 1 7 9 9 5 4 Domain of unknown function (DUF5082) Cep57_CLD_2 PF14197.6 EFA79563.1 - 0.0018 18.3 1.5 0.0018 18.3 1.5 13.4 6 6 5 11 11 9 2 Centrosome localisation domain of PPC89 APG6_N PF17675.1 EFA79563.1 - 0.0077 16.8 9.9 0.0077 16.8 9.9 11.6 3 2 8 11 11 9 4 Apg6 coiled-coil region ApoO PF09769.9 EFA79563.1 - 0.01 15.8 1.8 0.01 15.8 1.8 6.6 4 2 3 7 7 6 0 Apolipoprotein O Fungal_TACC PF12709.7 EFA79563.1 - 0.62 10.6 124.5 0.29 11.6 0.4 15.9 4 2 13 18 18 15 0 Fungal Transforming acidic coiled-coil (TACC) proteins Baculo_PEP_C PF04513.12 EFA79563.1 - 5.7 7.0 117.5 0.31 11.1 9.7 9.2 1 1 8 10 10 9 0 Baculovirus polyhedron envelope protein, PEP, C terminus Utp12 PF04003.12 EFA79565.1 - 3e-13 50.0 1.3 9.6e-13 48.4 0.8 2.0 2 0 0 2 2 2 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EFA79565.1 - 0.0034 17.6 0.9 1.3 9.4 0.1 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA79565.1 - 0.033 15.0 1.4 63 4.7 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat CAF1A PF12253.8 EFA79565.1 - 0.4 10.9 14.6 0.92 9.7 14.6 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Astro_capsid_p PF12226.8 EFA79565.1 - 0.92 8.6 15.4 2.1 7.4 15.2 1.7 1 1 0 1 1 1 0 Turkey astrovirus capsid protein UTP15_C PF09384.10 EFA79565.1 - 1.3 8.7 7.1 0.068 12.8 0.9 2.0 3 0 0 3 3 3 0 UTP15 C terminal fn3 PF00041.21 EFA79567.1 - 3.3e-28 97.9 36.4 0.00083 19.6 0.0 12.3 12 0 0 12 12 12 8 Fibronectin type III domain CD45 PF12567.8 EFA79567.1 - 2.3e-05 24.3 8.1 22 5.1 0.0 9.0 11 0 0 11 11 11 1 Leukocyte receptor CD45 EGF_2 PF07974.13 EFA79567.1 - 0.00037 20.8 13.9 0.00098 19.4 13.9 1.8 1 0 0 1 1 1 1 EGF-like domain Tissue_fac PF01108.17 EFA79567.1 - 0.085 12.7 27.5 2.8 7.8 0.3 8.5 7 2 2 9 9 9 0 Tissue factor Laminin_EGF PF00053.24 EFA79567.1 - 0.26 11.5 9.0 0.83 9.8 9.0 1.9 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 EFA79567.1 - 1.4 9.6 7.6 7.2 7.4 7.6 2.4 1 0 0 1 1 1 0 Human growth factor-like EGF DUF410 PF04190.13 EFA79568.1 - 1.1e-62 212.2 1.9 2.4e-62 211.1 1.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF410) Vps54_N PF10475.9 EFA79568.1 - 0.046 13.0 0.4 0.13 11.6 0.1 1.8 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex TIG PF01833.24 EFA79570.1 - 1.6e-06 28.1 1.9 1.6e-06 28.1 1.9 4.4 4 1 0 4 4 4 3 IPT/TIG domain Pro_isomerase PF00160.21 EFA79571.1 - 5.3e-47 160.0 0.3 6.3e-47 159.8 0.3 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-C3Hc3H PF13891.6 EFA79572.1 - 1.5e-10 41.3 3.9 2.7e-10 40.5 3.9 1.4 1 0 0 1 1 1 1 Potential DNA-binding domain zf-primase PF09329.11 EFA79572.1 - 8.1e-05 22.3 0.4 0.00035 20.3 0.4 2.1 1 0 0 1 1 1 1 Primase zinc finger CxC6 PF18721.1 EFA79572.1 - 0.78 10.1 5.6 0.75 10.1 2.1 2.5 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases zf-TRM13_CCCH PF11722.8 EFA79572.1 - 6.9 6.5 7.8 1.2 9.0 0.7 2.5 2 0 0 2 2 2 0 CCCH zinc finger in TRM13 protein DUF3818 PF12825.7 EFA79573.1 - 1.3e-17 63.8 9.1 4.7e-12 45.6 3.2 4.4 5 0 0 5 5 5 2 Domain of unknown function in PX-proteins (DUF3818) Arf PF00025.21 EFA79574.1 - 1.4e-44 151.7 0.0 2.3e-44 150.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA79574.1 - 1.1e-11 44.9 0.3 2.8e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFA79574.1 - 1.7e-10 40.6 1.6 3.1e-06 26.6 0.0 2.7 1 1 2 3 3 3 2 G-protein alpha subunit SRPRB PF09439.10 EFA79574.1 - 6.9e-07 28.9 0.1 1.7e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA79574.1 - 7.4e-07 28.9 0.1 2e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 Ras family Gtr1_RagA PF04670.12 EFA79574.1 - 1e-06 28.3 1.2 1.5e-06 27.8 0.0 1.8 3 0 0 3 3 3 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA79574.1 - 0.01 15.9 0.2 0.045 13.8 0.0 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase TLD PF07534.16 EFA79576.1 - 9.6e-24 84.2 0.1 9.6e-24 84.2 0.1 1.9 2 0 0 2 2 2 1 TLD CDC45 PF02724.14 EFA79576.1 - 0.73 8.1 5.9 0.95 7.7 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2956 PF11169.8 EFA79576.1 - 1.1 9.5 6.5 3.2 8.0 6.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Ig_5 PF16681.5 EFA79577.1 - 0.031 14.7 0.2 0.53 10.7 0.2 2.0 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain TrbI_Ftype PF09677.10 EFA79577.1 - 0.061 13.6 0.6 0.07 13.5 0.6 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) PPP4R2 PF09184.11 EFA79578.1 - 0.36 10.4 3.9 0.39 10.3 3.9 1.0 1 0 0 1 1 1 0 PPP4R2 Herpes_UL74 PF07982.12 EFA79578.1 - 0.53 9.2 5.9 0.59 9.0 5.9 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Macoilin PF09726.9 EFA79578.1 - 8.3 4.8 9.1 9.1 4.7 9.1 1.0 1 0 0 1 1 1 0 Macoilin family zf-B_box PF00643.24 EFA79579.1 - 6.6e-07 29.4 7.8 1.9e-06 27.9 7.8 1.8 1 0 0 1 1 1 1 B-box zinc finger DUF5074 PF16819.5 EFA79579.1 - 0.2 11.7 8.2 0.34 11.0 0.0 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF5074) PolyA_pol PF01743.20 EFA79580.1 - 1.8e-18 67.2 1.0 2.9e-18 66.5 0.0 1.8 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EFA79580.1 - 0.015 15.1 0.0 0.037 13.8 0.0 1.7 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A DUF1461 PF07314.11 EFA79580.1 - 0.38 10.6 3.4 3.6 7.5 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) Ank_2 PF12796.7 EFA79581.1 - 7.4e-39 132.2 0.0 5.4e-15 55.8 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 EFA79581.1 - 1.5e-31 109.3 6.9 3.3e-31 108.2 6.9 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ank_5 PF13857.6 EFA79581.1 - 2.2e-31 107.5 0.8 5.8e-08 32.9 0.0 6.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79581.1 - 5.2e-30 100.1 0.0 1.2e-06 28.3 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EFA79581.1 - 7.4e-30 102.9 1.3 6e-12 45.8 0.1 4.4 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFA79581.1 - 2.1e-26 91.2 0.1 5.4e-07 29.8 0.0 6.1 5 1 1 6 6 6 4 Ankyrin repeat IGFBP PF00219.18 EFA79581.1 - 0.64 10.7 5.9 2 9.1 5.9 1.8 1 0 0 1 1 1 0 Insulin-like growth factor binding protein IBR PF01485.21 EFA79582.1 - 0.0039 17.4 0.0 0.0039 17.4 0.0 2.9 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 EFA79582.1 - 0.41 10.6 11.9 0.042 13.7 7.2 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA79582.1 - 8.9 6.4 8.9 0.74 9.9 3.6 2.0 2 0 0 2 2 2 0 RING-type zinc-finger CG-1 PF03859.16 EFA79584.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 CG-1 domain AdenylateSensor PF16579.5 EFA79584.1 - 0.088 13.3 0.7 0.22 12.0 0.1 2.0 2 0 0 2 2 2 0 Adenylate sensor of SNF1-like protein kinase Myosin_head PF00063.21 EFA79585.1 - 2.3e-279 928.3 4.2 3e-279 928.0 4.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFA79585.1 - 1.2e-40 139.2 4.4 2.6e-40 138.1 4.4 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EFA79585.1 - 1.4e-10 40.0 5.6 1.8e-05 24.1 1.5 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif RsgA_GTPase PF03193.16 EFA79585.1 - 0.0077 16.2 0.1 0.033 14.1 0.0 2.1 1 1 0 1 1 1 1 RsgA GTPase Hpr_kinase_C PF07475.12 EFA79585.1 - 0.0078 15.8 0.2 3.6 7.1 0.1 3.2 3 0 0 3 3 3 1 HPr Serine kinase C-terminal domain Csm4_C PF17953.1 EFA79585.1 - 0.017 15.0 1.2 11 5.9 0.0 3.4 3 0 0 3 3 3 0 CRISPR Csm4 C-terminal domain AAA_16 PF13191.6 EFA79585.1 - 0.094 13.1 0.0 0.29 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain APOBEC1 PF18769.1 EFA79585.1 - 0.11 12.7 0.2 0.61 10.4 0.1 2.3 2 0 0 2 2 2 0 APOBEC1 AAA_22 PF13401.6 EFA79585.1 - 0.12 12.7 0.0 0.49 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain UQ_con PF00179.26 EFA79587.1 - 8.5e-54 181.0 0.0 9.5e-54 180.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFA79587.1 - 0.001 19.3 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EFA79587.1 - 0.0059 16.3 0.0 0.0074 16.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B Notch PF00066.17 EFA79588.1 - 5.5e-15 55.5 37.8 2e-08 34.5 10.6 2.6 3 0 0 3 3 3 2 LNR domain CALCOCO1 PF07888.11 EFA79588.1 - 0.15 10.9 10.0 0.12 11.3 1.6 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.12 EFA79588.1 - 1.1 9.3 17.3 1.5 8.9 4.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF724 PF05266.14 EFA79588.1 - 1.8 8.3 17.7 2.5 7.9 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF730 PF05325.11 EFA79588.1 - 2.7 8.0 9.3 4.8 7.2 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF730) SlyX PF04102.12 EFA79588.1 - 3 8.5 6.6 1.1 9.9 0.7 2.7 2 1 1 3 3 3 0 SlyX GREB1 PF15782.5 EFA79590.1 - 0.062 10.4 6.5 0.072 10.2 6.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Chorion_2 PF03964.15 EFA79590.1 - 0.13 13.1 9.2 0.31 11.9 4.4 2.5 2 1 0 2 2 2 0 Chorion family 2 OrfB_Zn_ribbon PF07282.11 EFA79590.1 - 0.2 11.6 6.4 4.5 7.3 0.0 3.9 4 0 0 4 4 4 0 Putative transposase DNA-binding domain Macoilin PF09726.9 EFA79590.1 - 2 6.9 11.6 2.6 6.5 11.6 1.2 1 0 0 1 1 1 0 Macoilin family Trypan_PARP PF05887.11 EFA79590.1 - 2.2 8.2 6.8 3.8 7.5 6.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Presenilin PF01080.17 EFA79590.1 - 3.2 6.4 7.4 4.4 6.0 7.4 1.2 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 EFA79590.1 - 7 5.4 13.1 0.36 9.6 8.3 1.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain SRP-alpha_N PF04086.13 EFA79590.1 - 7.3 6.4 19.0 8.5 6.2 14.4 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Dicty_CTDC PF00526.18 EFA79591.1 - 1.6e-21 75.8 64.4 1.3e-10 41.0 13.2 4.1 4 0 0 4 4 4 3 Dictyostelium (slime mold) repeat EGF_2 PF07974.13 EFA79592.1 - 3.7e-05 24.0 5.8 8.7e-05 22.8 5.8 1.7 1 0 0 1 1 1 1 EGF-like domain Podoplanin PF05808.11 EFA79592.1 - 0.0054 16.8 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 Podoplanin VSP PF03302.13 EFA79592.1 - 0.01 14.7 0.1 0.019 13.8 0.1 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein Laminin_EGF PF00053.24 EFA79592.1 - 0.42 10.8 4.5 0.84 9.8 4.5 1.4 1 0 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.13 EFA79593.1 - 4.9e-05 23.6 5.8 4.9e-05 23.6 5.8 1.8 2 0 0 2 2 2 1 EGF-like domain VSP PF03302.13 EFA79593.1 - 0.015 14.1 0.1 0.029 13.3 0.1 1.4 1 0 0 1 1 1 0 Giardia variant-specific surface protein Podoplanin PF05808.11 EFA79593.1 - 0.048 13.8 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Podoplanin Laminin_EGF PF00053.24 EFA79593.1 - 0.23 11.6 4.5 0.47 10.6 4.5 1.4 1 0 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.13 EFA79595.1 - 5.7e-05 23.4 7.8 0.00014 22.1 7.8 1.7 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 EFA79595.1 - 0.37 11.0 5.7 0.75 10.0 5.7 1.4 1 0 0 1 1 1 0 Laminin EGF domain DDE_Tnp_1_7 PF13843.6 EFA79596.1 - 2.8e-31 109.1 10.8 3.4e-30 105.5 6.2 2.7 1 1 1 2 2 2 2 Transposase IS4 Rho_N PF07498.12 EFA79596.1 - 0.13 12.2 1.1 0.3 11.0 1.1 1.6 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain DUF3464 PF11947.8 EFA79596.1 - 0.3 10.8 5.1 0.65 9.7 0.0 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Dehydrin PF00257.19 EFA79596.1 - 3 8.4 8.9 8.2 7.0 2.9 2.5 2 0 0 2 2 2 0 Dehydrin SSP160 PF06933.11 EFA79596.1 - 3.2 5.9 5.6 4.6 5.3 5.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4893 PF16233.5 EFA79597.1 - 0.016 14.8 0.0 0.021 14.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4893) Ank_4 PF13637.6 EFA79598.1 - 1.7e-28 98.6 11.8 8.7e-06 26.2 0.2 11.1 5 2 8 13 13 13 10 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79598.1 - 3.1e-24 85.4 4.9 0.00029 21.4 0.0 7.8 4 2 5 9 9 9 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79598.1 - 3.7e-17 60.7 4.3 2.4 9.0 0.0 14.6 17 1 1 18 18 18 3 Ankyrin repeat Ank_5 PF13857.6 EFA79598.1 - 1.9e-13 50.3 4.5 0.24 11.8 0.1 10.4 4 2 8 12 12 12 2 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA79598.1 - 0.013 15.4 32.2 0.87 9.6 1.0 8.1 5 1 3 8 8 8 0 Domain of unknown function (DUF3447) Ndc80_HEC PF03801.13 EFA79598.1 - 0.26 10.9 5.6 1.6 8.3 0.0 3.3 3 0 0 3 3 3 0 HEC/Ndc80p family EGF_2 PF07974.13 EFA79599.1 - 5e-05 23.6 7.8 0.00014 22.1 7.8 1.8 1 0 0 1 1 1 1 EGF-like domain EphA2_TM PF14575.6 EFA79599.1 - 0.075 13.9 0.4 0.14 13.0 0.4 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Podoplanin PF05808.11 EFA79599.1 - 0.1 12.7 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 Podoplanin Laminin_EGF PF00053.24 EFA79599.1 - 0.33 11.1 5.7 0.74 10.0 5.7 1.5 1 0 0 1 1 1 0 Laminin EGF domain PRKCSH-like PF12999.7 EFA79600.1 - 4.9e-42 143.7 11.9 4.9e-42 143.7 11.9 2.5 2 1 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EFA79600.1 - 4.1e-27 94.8 0.4 4.1e-27 94.8 0.4 2.2 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.18 EFA79600.1 - 0.0017 18.6 17.9 0.23 11.7 6.5 2.9 1 1 1 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH PF07915.13 EFA79600.1 - 0.033 15.2 2.4 0.033 15.2 2.4 3.2 2 2 0 2 2 2 0 Glucosidase II beta subunit-like protein KxDL PF10241.9 EFA79600.1 - 0.18 12.1 4.3 1.6 9.0 2.8 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein BUD22 PF09073.10 EFA79600.1 - 0.52 9.6 37.5 0.78 9.0 37.5 1.2 1 0 0 1 1 1 0 BUD22 FlaC_arch PF05377.11 EFA79600.1 - 0.76 10.2 12.2 1.7 9.1 2.1 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EFA79600.1 - 2.1 8.4 6.3 2.6 8.1 4.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4252 PF14060.6 EFA79602.1 - 0.062 13.2 1.6 0.2 11.5 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) Ank_2 PF12796.7 EFA79603.1 - 1e-24 86.9 3.7 3.7e-08 33.8 0.1 5.3 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79603.1 - 1.3e-22 79.9 5.2 0.00014 22.3 0.0 7.7 5 3 5 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79603.1 - 1.1e-15 56.2 4.6 1.1 10.0 0.0 10.7 11 1 1 12 12 12 2 Ankyrin repeat Ank_5 PF13857.6 EFA79603.1 - 8.9e-12 45.0 2.5 1 9.8 0.0 8.0 3 2 6 9 9 9 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA79603.1 - 0.0012 19.2 1.0 11 6.7 0.0 5.5 7 0 0 7 7 7 1 Ankyrin repeat DUF1843 PF08898.10 EFA79603.1 - 0.032 14.7 0.4 1e+02 3.5 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) LURAP PF14854.6 EFA79603.1 - 0.035 14.0 8.2 1.5 8.8 0.1 5.3 2 1 4 6 6 6 0 Leucine rich adaptor protein Ins_allergen_rp PF06757.13 EFA79603.1 - 0.055 13.4 1.6 0.19 11.7 0.3 2.4 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification Xin PF08043.12 EFA79603.1 - 0.11 12.2 6.1 2.9 7.6 0.0 4.3 4 0 0 4 4 4 0 Xin repeat Helicase_PWI PF18149.1 EFA79603.1 - 0.51 10.5 7.8 2.1 8.5 0.0 3.3 4 0 0 4 4 4 0 N-terminal helicase PWI domain Ank_4 PF13637.6 EFA79604.1 - 0.0014 19.1 0.0 0.004 17.7 0.0 1.8 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79604.1 - 0.0054 17.3 0.0 0.0072 16.9 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Bacteriocin_IIi PF11758.8 EFA79604.1 - 0.01 15.6 0.6 0.34 10.8 0.1 2.3 2 0 0 2 2 2 0 Aureocin-like type II bacteriocin Ank_3 PF13606.6 EFA79604.1 - 0.052 14.1 0.1 25 5.9 0.0 2.9 1 1 1 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EFA79604.1 - 0.077 13.3 0.0 0.73 10.2 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Polo_box_2 PF18531.1 EFA79606.1 - 3.5 7.8 6.5 6.1 7.0 0.8 2.7 1 1 1 2 2 2 0 Polo box domain DEAD PF00270.29 EFA79607.1 - 3.9e-44 150.5 0.1 4.8e-44 150.2 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFA79607.1 - 1.6e-06 28.2 0.0 2.2e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFA79607.1 - 0.01 16.1 0.1 0.027 14.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain SecA_DEAD PF07517.14 EFA79607.1 - 0.015 14.6 0.1 0.08 12.2 0.2 1.8 1 1 0 1 1 1 0 SecA DEAD-like domain Helicase_RecD PF05127.14 EFA79607.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 Helicase Ank_2 PF12796.7 EFA79608.1 - 1.7e-06 28.5 0.0 3.4e-06 27.6 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79608.1 - 3.4e-06 27.5 0.1 7.5e-06 26.4 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79608.1 - 1.2e-05 25.5 0.0 0.11 12.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79608.1 - 0.0029 18.0 0.2 2.3 9.1 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFA79608.1 - 0.076 13.5 0.3 2.4 8.8 0.1 2.5 2 1 0 2 2 2 0 Ankyrin repeat BNIP2 PF12496.8 EFA79609.1 - 0.53 10.7 9.4 0.096 13.1 2.8 2.7 3 0 0 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Cwf_Cwc_15 PF04889.12 EFA79609.1 - 1.3 8.7 10.7 0.97 9.1 6.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Arf PF00025.21 EFA79612.1 - 9e-24 83.9 0.2 2.9e-13 49.6 0.0 2.0 1 1 1 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 EFA79612.1 - 0.00069 18.9 0.6 0.0009 18.5 0.6 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Caenor_Her-1 PF09232.10 EFA79612.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.5 2 0 0 2 2 2 0 Caenorhabditis elegans Her-1 Arf PF00025.21 EFA79613.1 - 3.4e-21 75.5 0.1 1.1e-16 60.8 0.1 2.0 1 1 1 2 2 2 2 ADP-ribosylation factor family SRPRB PF09439.10 EFA79613.1 - 0.00051 19.5 0.1 0.00063 19.2 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFA79613.1 - 0.0016 17.7 0.4 0.0033 16.6 0.4 1.5 1 1 0 1 1 1 1 G-protein alpha subunit DLH PF01738.18 EFA79613.1 - 0.0054 16.3 0.0 0.009 15.6 0.0 1.3 1 1 0 1 1 1 1 Dienelactone hydrolase family TFIIE_beta PF02186.15 EFA79613.1 - 0.028 14.7 0.4 0.063 13.6 0.1 1.7 2 0 0 2 2 2 0 TFIIE beta subunit core domain FSIP2 PF15783.5 EFA79613.1 - 0.03 12.3 0.2 0.037 12.0 0.2 1.0 1 0 0 1 1 1 0 Fibrous sheath-interacting protein 2 CutA1 PF03091.15 EFA79614.1 - 0.012 15.5 0.0 0.041 13.7 0.0 1.9 2 0 0 2 2 2 0 CutA1 divalent ion tolerance protein Kelch_6 PF13964.6 EFA79616.1 - 3.3e-10 39.9 5.8 8.3e-06 25.9 0.1 4.2 4 1 1 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA79616.1 - 8.7e-05 22.6 6.9 0.00022 21.3 6.9 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA79616.1 - 0.0016 18.7 0.4 0.013 15.8 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA79616.1 - 0.13 12.2 3.1 7.9 6.6 0.1 3.3 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA79616.1 - 0.14 11.8 0.2 0.45 10.1 0.0 2.0 2 0 0 2 2 2 0 Kelch motif Phasin PF05597.11 EFA79616.1 - 0.28 11.2 2.8 0.2 11.7 0.6 1.8 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Kelch_5 PF13854.6 EFA79616.1 - 0.54 10.3 1.8 4 7.5 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Ank_4 PF13637.6 EFA79617.1 - 2.8e-30 104.3 2.5 0.00029 21.3 0.0 10.7 8 4 3 12 12 12 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79617.1 - 4.7e-29 100.8 0.1 3.1e-06 27.7 0.0 7.4 2 2 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79617.1 - 1.4e-18 65.0 0.5 4.6 8.1 0.0 14.7 15 3 3 18 18 18 2 Ankyrin repeat Ank_5 PF13857.6 EFA79617.1 - 2.2e-17 62.9 0.0 2.5 8.5 0.0 11.0 9 1 2 11 11 11 5 Ankyrin repeats (many copies) LURAP PF14854.6 EFA79617.1 - 0.24 11.3 5.9 2.6 8.0 0.4 4.9 3 1 3 6 6 6 0 Leucine rich adaptor protein Actin PF00022.19 EFA79618.1 - 8.1e-126 419.9 0.0 3.4e-125 417.8 0.0 1.7 1 1 0 1 1 1 1 Actin FXa_inhibition PF14670.6 EFA79619.1 - 3.3e-207 670.4 453.3 6.4e-13 48.7 11.4 23.4 23 0 0 23 23 23 20 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EFA79619.1 - 2.2e-188 609.4 215.4 2e-11 43.6 1.2 25.0 25 1 0 25 25 25 19 Complement Clr-like EGF-like EGF_CA PF07645.15 EFA79619.1 - 2.8e-124 405.1 415.4 7.8e-08 32.4 11.9 22.9 22 1 1 23 23 23 20 Calcium-binding EGF domain EGF_3 PF12947.7 EFA79619.1 - 1.4e-54 182.0 445.8 0.00077 19.6 12.5 22.5 22 0 0 22 22 22 20 EGF domain EGF PF00008.27 EFA79619.1 - 2.1e-24 85.4 383.0 0.0092 16.3 8.1 24.3 24 0 0 24 24 24 21 EGF-like domain hEGF PF12661.7 EFA79619.1 - 0.005 17.4 335.3 0.05 14.3 5.8 25.6 24 1 0 24 24 24 13 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 EFA79619.1 - 1.2 9.5 365.7 0.033 14.5 6.9 21.8 21 0 0 21 21 21 0 Pvs28 EGF domain DUF4375 PF14300.6 EFA79619.1 - 3.2 8.0 43.8 74 3.6 0.1 14.5 16 1 1 17 17 17 0 Domain of unknown function (DUF4375) CENP-B_dimeris PF09026.10 EFA79620.1 - 0.0009 19.6 11.2 0.0009 19.6 11.2 1.8 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Radial_spoke PF04712.12 EFA79620.1 - 0.0043 16.0 9.1 0.0046 16.0 9.1 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein SAP PF02037.27 EFA79620.1 - 0.005 16.6 1.2 0.0057 16.4 0.0 1.7 2 0 0 2 2 1 1 SAP domain FAM176 PF14851.6 EFA79620.1 - 0.013 15.1 4.9 0.019 14.6 4.9 1.3 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 EFA79620.1 - 0.031 14.1 6.8 0.032 14.0 6.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sigma70_ner PF04546.13 EFA79620.1 - 0.035 14.0 12.3 0.038 13.9 12.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region COR PF16095.5 EFA79620.1 - 0.047 13.5 0.0 0.065 13.0 0.0 1.3 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain SDA1 PF05285.12 EFA79620.1 - 0.051 13.0 15.4 0.052 13.0 15.4 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFA79620.1 - 0.073 11.3 14.8 0.078 11.2 14.8 1.1 1 0 0 1 1 1 0 Nop14-like family CSRNP_N PF16019.5 EFA79620.1 - 0.079 12.9 1.4 0.081 12.8 1.4 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus D123 PF07065.14 EFA79620.1 - 0.084 12.0 4.0 0.095 11.8 4.0 1.1 1 0 0 1 1 1 0 D123 GOLD_2 PF13897.6 EFA79620.1 - 0.1 13.1 2.8 0.13 12.8 2.8 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DNA_pol_phi PF04931.13 EFA79620.1 - 0.11 10.6 13.5 0.11 10.6 13.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi RPN2_C PF18004.1 EFA79620.1 - 0.13 12.2 7.3 0.16 11.9 7.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Saw1 PF11561.8 EFA79620.1 - 0.14 11.6 2.9 0.17 11.4 2.9 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 TRAP_alpha PF03896.16 EFA79620.1 - 0.17 11.1 5.5 0.19 10.9 5.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1676 PF07898.13 EFA79620.1 - 0.23 11.5 0.6 0.31 11.1 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Roughex PF06020.11 EFA79620.1 - 0.26 10.4 8.6 0.26 10.3 8.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Tim54 PF11711.8 EFA79620.1 - 0.27 10.0 4.7 0.31 9.8 4.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 YL1 PF05764.13 EFA79620.1 - 0.37 10.9 16.0 0.39 10.8 16.0 1.1 1 0 0 1 1 1 0 YL1 nuclear protein PI3K_1B_p101 PF10486.9 EFA79620.1 - 0.37 8.5 3.5 0.37 8.5 3.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 EFA79620.1 - 0.56 8.4 12.0 0.57 8.4 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EFA79620.1 - 1.1 8.5 19.5 1.4 8.2 19.5 1.2 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.11 EFA79620.1 - 2 6.4 6.8 2.2 6.2 6.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CobT PF06213.12 EFA79620.1 - 2 7.7 11.3 2.6 7.4 11.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4637 PF15470.6 EFA79620.1 - 2.9 7.6 11.0 3.7 7.3 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) E7 PF00527.18 EFA79620.1 - 7.2 6.9 12.7 14 6.0 12.7 1.6 1 1 0 1 1 1 0 E7 protein, Early protein RRN3 PF05327.11 EFA79620.1 - 7.3 5.0 10.6 8 4.9 10.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Imm44 PF15571.6 EFA79622.1 - 0.0057 16.9 0.6 0.0069 16.6 0.6 1.2 1 0 0 1 1 1 1 Immunity protein 44 ParA PF10609.9 EFA79622.1 - 0.029 13.8 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase NOA36 PF06524.12 EFA79622.1 - 1 8.6 14.2 1.3 8.3 14.2 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4874 PF16173.5 EFA79623.1 - 0.056 13.1 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) F-box-like PF12937.7 EFA79623.1 - 0.087 12.7 0.0 0.28 11.1 0.0 1.9 1 1 0 1 1 1 0 F-box-like Sugar_tr PF00083.24 EFA79624.1 - 1.5e-97 327.3 34.0 2.1e-97 326.8 34.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFA79624.1 - 1e-29 103.6 55.4 1.8e-27 96.2 29.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily HAV_VP PF12944.7 EFA79624.1 - 0.016 15.2 0.1 0.04 13.9 0.1 1.7 1 0 0 1 1 1 0 Hepatitis A virus viral protein VP Orbi_NS3 PF01616.16 EFA79624.1 - 0.12 12.1 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Orbivirus NS3 ACBP PF00887.19 EFA79625.1 - 2.5e-28 98.1 2.3 2.7e-28 98.0 2.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Peptidase_M61_N PF17899.1 EFA79625.1 - 0.031 14.4 0.1 0.033 14.3 0.1 1.2 1 0 0 1 1 1 0 Peptidase M61 N-terminal domain AD PF09793.9 EFA79626.1 - 5.1e-27 93.8 0.1 7.5e-27 93.3 0.1 1.2 1 0 0 1 1 1 1 Anticodon-binding domain Gemin6 PF06372.12 EFA79626.1 - 0.001 18.6 0.6 0.051 13.1 0.2 2.2 2 0 0 2 2 2 2 Gemin6 protein Peptidase_M11 PF05548.11 EFA79626.1 - 0.061 12.5 0.0 0.075 12.2 0.0 1.1 1 0 0 1 1 1 0 Gametolysin peptidase M11 Sec16_C PF12931.7 EFA79627.1 - 7.4e-48 163.7 0.0 1.9e-47 162.4 0.0 1.7 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EFA79627.1 - 4.3e-08 33.8 0.0 4.3e-08 33.8 0.0 5.6 6 1 1 7 7 7 1 Vesicle coat trafficking protein Sec16 mid-region Caldesmon PF02029.15 EFA79627.1 - 8.4 5.0 49.0 0.6 8.8 14.9 2.2 2 0 0 2 2 2 0 Caldesmon HSP70 PF00012.20 EFA79628.1 - 3.3e-19 68.5 0.0 4.1e-19 68.2 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Isochorismatase PF00857.20 EFA79628.1 - 1.4e-06 28.6 0.0 1.9e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family zf-B_box PF00643.24 EFA79629.1 - 3.4e-05 23.9 7.5 3.4e-05 23.9 7.5 2.1 2 0 0 2 2 2 1 B-box zinc finger Kelch_6 PF13964.6 EFA79629.1 - 0.00026 21.2 9.1 0.2 12.0 0.3 5.5 4 1 1 5 5 5 1 Kelch motif ROQ_II PF18386.1 EFA79629.1 - 0.013 15.3 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 Roquin II domain RPW8 PF05659.11 EFA79629.1 - 1.6 8.5 6.6 0.62 9.8 1.4 2.9 3 1 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_2 PF07724.14 EFA79630.1 - 2.1e-58 197.2 0.0 1.9e-53 181.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFA79630.1 - 5.1e-37 126.0 2.0 5.1e-37 126.0 2.0 2.7 2 1 1 3 3 2 1 AAA lid domain AAA PF00004.29 EFA79630.1 - 3.2e-27 95.5 0.0 2.6e-14 53.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFA79630.1 - 3.7e-23 81.4 5.1 3.8e-23 81.3 0.1 3.5 3 0 0 3 3 3 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFA79630.1 - 1.3e-17 64.1 0.5 4e-11 43.1 0.0 3.6 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 EFA79630.1 - 2.9e-17 62.5 2.5 3.2e-09 36.8 0.3 2.9 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 EFA79630.1 - 7.5e-12 46.0 7.1 1.1e-05 25.9 0.0 5.0 4 2 1 6 6 5 2 AAA ATPase domain Sigma54_activat PF00158.26 EFA79630.1 - 1.1e-10 41.5 0.0 1.6e-06 27.9 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EFA79630.1 - 3e-08 34.0 0.3 0.038 14.3 0.0 4.4 2 2 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EFA79630.1 - 7.8e-08 32.3 0.0 0.0025 17.6 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 EFA79630.1 - 2.4e-07 30.9 0.0 0.025 14.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 EFA79630.1 - 1.7e-06 27.6 0.3 0.0027 17.1 0.0 3.7 3 1 0 3 3 3 1 Bacterial TniB protein AAA_7 PF12775.7 EFA79630.1 - 2.2e-06 27.3 0.0 0.0062 16.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region RuvB_N PF05496.12 EFA79630.1 - 3.1e-06 27.0 0.5 0.12 12.1 0.0 4.3 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFA79630.1 - 5.3e-06 27.0 0.1 0.2 12.2 0.0 3.7 3 0 0 3 3 3 2 AAA domain ATPase_2 PF01637.18 EFA79630.1 - 2.8e-05 24.2 6.6 0.78 9.6 0.0 4.7 4 2 0 5 5 4 2 ATPase domain predominantly from Archaea NACHT PF05729.12 EFA79630.1 - 4.8e-05 23.3 0.0 0.13 12.2 0.0 2.8 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.22 EFA79630.1 - 0.00016 22.0 0.0 0.57 10.6 0.0 3.0 3 0 0 3 3 2 1 RNA helicase AAA_3 PF07726.11 EFA79630.1 - 0.0003 20.7 0.0 0.21 11.4 0.0 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EFA79630.1 - 0.0003 21.0 0.0 0.48 10.7 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFA79630.1 - 0.00032 20.6 0.8 2.7 7.9 0.0 4.0 4 0 0 4 4 3 1 RsgA GTPase AAA_33 PF13671.6 EFA79630.1 - 0.00056 20.1 0.0 0.67 10.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EFA79630.1 - 0.00061 19.8 0.0 2.6 8.1 0.0 3.0 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EFA79630.1 - 0.00077 18.8 0.0 0.1 11.9 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 EFA79630.1 - 0.00088 18.9 0.5 0.3 10.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EFA79630.1 - 0.0014 18.9 0.1 4.8 7.4 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 EFA79630.1 - 0.0016 18.2 0.0 1.4 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFA79630.1 - 0.0019 17.7 0.1 1.6 8.0 0.0 3.6 3 1 0 3 3 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EFA79630.1 - 0.0023 18.5 3.1 0.75 10.3 0.0 4.2 3 1 0 3 3 3 1 ABC transporter DNA_pol3_delta2 PF13177.6 EFA79630.1 - 0.0023 17.7 0.0 0.046 13.5 0.0 3.0 3 1 0 3 3 1 1 DNA polymerase III, delta subunit DUF815 PF05673.13 EFA79630.1 - 0.0029 16.8 0.1 2.6 7.2 0.0 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF815) AAA_23 PF13476.6 EFA79630.1 - 0.0051 17.3 14.8 0.58 10.6 0.0 3.8 2 1 1 3 3 3 1 AAA domain T2SSE PF00437.20 EFA79630.1 - 0.019 14.0 0.1 0.055 12.5 0.0 1.9 2 0 0 2 2 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 EFA79630.1 - 0.02 15.2 0.1 0.56 10.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 EFA79630.1 - 0.025 14.0 0.0 0.27 10.7 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein FTA4 PF13093.6 EFA79630.1 - 0.025 14.5 7.5 0.014 15.3 4.9 2.0 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 SRP54 PF00448.22 EFA79630.1 - 0.036 13.7 0.4 9.3 5.8 0.0 3.4 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain ResIII PF04851.15 EFA79630.1 - 0.036 14.1 0.0 2.7 7.9 0.0 3.4 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFA79630.1 - 0.062 13.0 0.0 6.2 6.5 0.0 3.1 2 1 0 2 2 2 0 AAA domain AAA_8 PF12780.7 EFA79630.1 - 0.066 12.5 0.1 16 4.7 0.1 2.8 2 1 0 2 2 2 0 P-loop containing dynein motor region D4 Rx_N PF18052.1 EFA79630.1 - 0.081 13.2 5.3 5.8 7.3 5.2 3.3 2 1 0 2 2 2 0 Rx N-terminal domain AAA_29 PF13555.6 EFA79630.1 - 0.083 12.6 0.0 12 5.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Matrilin_ccoil PF10393.9 EFA79630.1 - 0.12 12.2 0.8 4.6 7.2 0.1 2.8 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF87 PF01935.17 EFA79630.1 - 0.14 12.2 8.0 0.74 9.9 0.0 3.9 4 0 0 4 4 4 0 Helicase HerA, central domain ArsA_ATPase PF02374.15 EFA79630.1 - 0.21 10.7 2.5 6.6 5.8 0.0 3.1 3 1 0 3 3 2 0 Anion-transporting ATPase DUF4515 PF14988.6 EFA79630.1 - 0.32 10.8 16.4 0.23 11.3 5.7 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4515) Spc7 PF08317.11 EFA79630.1 - 0.33 9.8 16.1 0.66 8.8 16.1 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 EFA79630.1 - 8.1 6.9 11.3 38 4.8 3.1 3.4 2 1 1 3 3 3 0 Snapin/Pallidin Atg14 PF10186.9 EFA79630.1 - 8.3 5.4 10.5 15 4.6 10.5 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CRM1_C PF08767.11 EFA79631.1 - 1.2e-109 366.3 13.2 1.2e-109 366.3 13.2 4.0 4 0 0 4 4 4 1 CRM1 C terminal CRM1_repeat_2 PF18784.1 EFA79631.1 - 3.2e-32 110.0 1.2 1.1e-31 108.2 1.2 2.1 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 Xpo1 PF08389.12 EFA79631.1 - 9.3e-32 110.1 6.2 9.3e-32 110.1 6.2 4.3 5 0 0 5 5 5 1 Exportin 1-like protein CRM1_repeat_3 PF18787.1 EFA79631.1 - 9.4e-26 89.7 0.6 4e-25 87.7 0.3 2.4 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 IBN_N PF03810.19 EFA79631.1 - 3.4e-16 58.9 1.3 1.2e-15 57.1 0.1 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 EFA79631.1 - 9.3e-15 53.9 0.8 9.3e-15 53.9 0.8 2.4 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat Kelch_6 PF13964.6 EFA79631.1 - 1.6e-08 34.5 8.4 0.00011 22.4 0.3 5.0 4 1 1 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA79631.1 - 0.0036 17.4 6.5 0.0099 16.0 6.5 1.7 1 0 0 1 1 1 1 B-box zinc finger Vac14_Fab1_bd PF12755.7 EFA79631.1 - 0.032 14.8 0.4 5.2 7.7 0.0 3.9 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region TFIIS_M PF07500.14 EFA79631.1 - 0.04 14.4 2.5 0.051 14.1 0.2 2.4 2 0 0 2 2 1 0 Transcription factor S-II (TFIIS), central domain Kelch_2 PF07646.15 EFA79631.1 - 0.12 12.4 1.4 1.9 8.6 0.4 2.8 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 EFA79631.1 - 0.54 9.9 4.3 8.3 6.1 0.2 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 EFA79631.1 - 1 9.4 6.8 1.3 9.1 1.2 3.1 3 0 0 3 3 3 0 Kelch motif ArfGap PF01412.18 EFA79631.1 - 3 7.9 7.6 0.87 9.7 2.8 2.4 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Kelch_4 PF13418.6 EFA79631.1 - 3.4 7.7 7.4 5.9 7.0 0.3 4.2 4 0 0 4 4 4 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA79633.1 - 1.2e-05 25.4 9.9 1.9e-05 24.7 9.9 1.3 1 0 0 1 1 1 1 B-box zinc finger RNA_pol_Rpb1_1 PF04997.12 EFA79633.1 - 0.017 14.5 1.9 0.017 14.5 1.9 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 Phi-29_GP16_7 PF06720.11 EFA79633.1 - 0.018 14.9 1.3 0.021 14.7 1.3 1.1 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Zn_Tnp_IS91 PF14319.6 EFA79633.1 - 0.2 11.7 6.1 1.4 9.0 4.9 2.0 1 1 1 2 2 2 0 Transposase zinc-binding domain NinE PF05322.11 EFA79633.1 - 0.32 10.9 3.0 0.45 10.4 1.2 2.1 2 1 0 2 2 2 0 NINE Protein Helicase_C PF00271.31 EFA79634.1 - 2.8e-21 75.9 0.2 1.4e-19 70.5 0.1 3.1 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFA79634.1 - 1e-14 54.5 0.6 2.3e-14 53.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) DEAD PF00270.29 EFA79634.1 - 2.4e-09 37.2 0.1 9.6e-09 35.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD PF00270.29 EFA79635.1 - 0.0023 17.7 0.0 0.0048 16.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Dapper PF15268.6 EFA79635.1 - 1.8 7.3 19.9 2 7.1 19.9 1.0 1 0 0 1 1 1 0 Dapper LAP1C PF05609.12 EFA79635.1 - 3.1 6.8 18.6 3.7 6.5 18.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 EFA79635.1 - 6.2 5.5 19.7 8.7 5.0 19.7 1.4 1 0 0 1 1 1 0 Presenilin Gal_mutarotas_3 PF18080.1 EFA79636.1 - 0.32 10.9 2.5 0.37 10.7 2.5 1.1 1 0 0 1 1 1 0 Galactose mutarotase-like fold domain Myosin_head PF00063.21 EFA79637.1 - 4.3e-215 715.9 19.6 5.3e-207 689.2 14.1 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) IQ PF00612.27 EFA79637.1 - 8.5e-09 34.4 21.8 0.00035 20.1 1.6 6.9 7 0 0 7 7 7 2 IQ calmodulin-binding motif Myosin_N PF02736.19 EFA79637.1 - 3.7e-06 26.7 0.3 7.7e-06 25.6 0.3 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EFA79637.1 - 0.02 15.2 1.2 0.11 12.8 0.0 2.9 2 0 0 2 2 2 0 AAA domain Spc7 PF08317.11 EFA79637.1 - 0.13 11.1 31.8 0.32 9.8 20.1 2.6 2 0 0 2 2 2 0 Spc7 kinetochore protein AAA_16 PF13191.6 EFA79637.1 - 0.2 12.1 0.0 0.2 12.1 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain Tropomyosin_1 PF12718.7 EFA79637.1 - 0.24 11.6 32.4 0.74 10.0 19.8 3.0 2 0 0 2 2 2 0 Tropomyosin like DUF1664 PF07889.12 EFA79637.1 - 1.9 8.6 14.5 2 8.5 8.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4905 PF16248.5 EFA79638.1 - 0.0081 16.0 0.0 0.1 12.5 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4905) Cation_ATPase_C PF00689.21 EFA79639.1 - 1.5e-45 155.2 3.7 1.5e-45 155.2 3.7 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFA79639.1 - 8e-41 139.5 0.5 8e-41 139.5 0.5 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFA79639.1 - 4.1e-17 62.0 0.1 7.9e-17 61.1 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA79639.1 - 9e-17 62.1 0.0 2.5e-16 60.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA79639.1 - 5.5e-11 42.0 0.0 1.1e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA79639.1 - 0.0016 18.3 3.1 0.012 15.3 0.2 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Ferlin_C PF16165.5 EFA79639.1 - 0.021 14.8 0.0 0.058 13.3 0.0 1.7 1 0 0 1 1 1 0 Ferlin C-terminus Cuticle_1 PF08140.11 EFA79639.1 - 0.034 14.2 0.1 0.89 9.6 0.1 3.3 3 0 0 3 3 3 0 Crustacean cuticle protein repeat Kelch_6 PF13964.6 EFA79640.1 - 0.011 16.1 0.3 4.2 7.8 0.0 3.0 3 0 0 3 3 3 0 Kelch motif SBBP PF06739.11 EFA79640.1 - 0.099 12.7 2.0 0.47 10.5 0.3 3.0 3 0 0 3 3 3 0 Beta-propeller repeat SSP160 PF06933.11 EFA79641.1 - 0.00036 18.9 5.1 0.00059 18.2 5.1 1.3 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 CENP-F_N PF10481.9 EFA79641.1 - 0.0052 16.5 0.3 0.0052 16.5 0.3 2.3 2 1 1 3 3 3 1 Cenp-F N-terminal domain MLVIN_C PF18697.1 EFA79641.1 - 0.02 15.0 0.0 0.081 13.0 0.0 2.1 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain fn3 PF00041.21 EFA79643.1 - 6.2e-21 74.5 25.8 0.00081 19.7 0.0 9.5 9 1 0 9 9 9 5 Fibronectin type III domain DUF2369 PF10179.9 EFA79643.1 - 2.1e-11 44.0 9.0 0.15 12.4 0.0 6.9 7 0 0 7 7 7 4 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 EFA79643.1 - 1.9e-07 31.5 17.9 0.059 13.9 0.1 6.9 5 1 1 6 6 6 2 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 EFA79643.1 - 4.2e-05 23.3 17.7 5e-05 23.1 0.3 6.2 4 2 3 7 7 7 1 Tissue factor EGF_2 PF07974.13 EFA79643.1 - 0.00032 21.0 12.2 0.0011 19.3 12.2 2.0 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA79643.1 - 0.01 16.1 2.6 0.058 13.7 1.3 2.9 2 0 0 2 2 2 0 EB module DUF441 PF04284.13 EFA79643.1 - 0.12 12.4 0.8 0.34 10.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF441) EGF PF00008.27 EFA79643.1 - 0.21 11.9 9.2 0.063 13.6 5.3 2.4 2 0 0 2 2 2 0 EGF-like domain ObR_Ig PF18589.1 EFA79643.1 - 1 9.8 19.6 12 6.4 0.0 6.8 9 0 0 9 9 9 0 Obesity receptor immunoglobulin like domain Kelch_6 PF13964.6 EFA79645.1 - 7e-09 35.7 1.0 0.0044 17.3 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFA79645.1 - 1.8e-07 31.2 0.4 0.0075 16.5 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Rax2 PF12768.7 EFA79645.1 - 0.0017 17.9 0.7 0.0017 17.9 0.7 1.6 2 0 0 2 2 2 1 Cortical protein marker for cell polarity Kelch_4 PF13418.6 EFA79645.1 - 0.0058 16.6 3.3 2 8.5 0.1 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA79645.1 - 0.093 12.7 1.6 0.23 11.5 0.2 2.4 3 0 0 3 3 3 0 Kelch motif DUF5074 PF16819.5 EFA79645.1 - 0.36 10.9 5.5 2.1 8.4 0.8 3.3 1 1 0 2 2 2 0 Domain of unknown function (DUF5074) zf-B_box PF00643.24 EFA79646.1 - 5.3e-06 26.5 10.1 5.3e-06 26.5 10.1 1.8 2 0 0 2 2 2 1 B-box zinc finger Cep57_CLD PF14073.6 EFA79646.1 - 0.0032 17.5 11.0 0.0032 17.5 11.0 1.6 1 1 1 2 2 2 1 Centrosome localisation domain of Cep57 DUF4164 PF13747.6 EFA79646.1 - 0.023 14.9 1.9 0.75 10.1 1.9 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) Kelch_6 PF13964.6 EFA79647.1 - 1.3e-11 44.4 3.1 1.1e-05 25.5 0.1 4.7 4 0 0 4 4 4 3 Kelch motif zf-B_box PF00643.24 EFA79647.1 - 5.4e-07 29.7 6.9 1.3e-06 28.4 6.9 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA79647.1 - 0.002 18.3 0.1 0.26 11.6 0.0 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Cep57_CLD PF14073.6 EFA79647.1 - 0.0091 16.0 8.9 0.0091 16.0 8.9 2.1 2 0 0 2 2 2 1 Centrosome localisation domain of Cep57 Kelch_4 PF13418.6 EFA79647.1 - 2.1 8.4 5.8 6.4 6.9 0.1 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Phasin PF05597.11 EFA79647.1 - 8.9 6.3 8.0 1.3 9.0 1.7 2.3 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) LRR_6 PF13516.6 EFA79648.1 - 2.5e-10 39.6 14.0 8.7e-05 22.3 0.8 5.4 5 0 0 5 5 5 3 Leucine Rich repeat Pentapeptide PF00805.22 EFA79648.1 - 0.0046 16.6 0.1 0.013 15.2 0.1 1.8 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFA79648.1 - 0.0095 16.1 0.4 0.036 14.2 0.4 1.9 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) LRR_4 PF12799.7 EFA79648.1 - 0.026 15.0 20.5 0.037 14.5 0.3 4.4 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA79648.1 - 0.87 10.4 14.7 1.6 9.5 2.7 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat NUMOD1 PF07453.13 EFA79648.1 - 7.2 7.0 9.5 13 6.2 0.1 3.2 3 0 0 3 3 3 0 NUMOD1 domain ADH_N PF08240.12 EFA79649.1 - 2.2e-27 95.1 6.5 4.7e-27 94.0 6.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFA79649.1 - 4.4e-17 62.3 0.0 7.5e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA79649.1 - 0.002 19.2 0.0 0.0041 18.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase F-box-like PF12937.7 EFA79649.1 - 0.0035 17.2 0.0 0.0086 15.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like ELFV_dehydrog PF00208.21 EFA79649.1 - 0.11 12.1 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ADH_N_2 PF16884.5 EFA79649.1 - 0.15 11.9 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Secretin_N_2 PF07655.13 EFA79649.1 - 0.32 11.6 8.8 0.78 10.3 8.8 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain UCH PF00443.29 EFA79650.1 - 1.2e-39 136.4 17.0 1.1e-26 93.9 0.0 4.4 4 1 0 4 4 4 3 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA79650.1 - 1.4e-11 44.6 46.6 2.8e-08 33.7 34.2 5.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UN_NPL4 PF11543.8 EFA79650.1 - 0.0046 17.4 0.3 0.19 12.2 0.0 3.8 4 0 0 4 4 4 1 Nuclear pore localisation protein NPL4 PB1 PF00564.24 EFA79650.1 - 0.076 13.0 0.1 0.49 10.4 0.0 2.4 2 0 0 2 2 2 0 PB1 domain FSA_C PF10479.9 EFA79650.1 - 0.44 8.6 22.2 1.6 6.8 1.9 2.4 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus Mucin PF01456.17 EFA79650.1 - 2.3 8.2 51.5 0.21 11.6 16.8 2.8 2 0 0 2 2 2 0 Mucin-like glycoprotein Stealth_CR2 PF11380.8 EFA79651.1 - 2.7e-41 140.1 2.5 4.7e-41 139.3 1.3 2.0 3 0 0 3 3 3 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EFA79651.1 - 1.3e-12 47.4 0.1 2.4e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 EFA79651.1 - 8e-12 44.7 0.0 1.5e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 EFA79651.1 - 4.2e-09 36.2 0.1 9.6e-09 35.0 0.1 1.6 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 DUF2498 PF10692.9 EFA79651.1 - 0.066 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) Kelch_6 PF13964.6 EFA79652.1 - 4.2e-08 33.2 2.0 0.00051 20.2 0.2 4.1 3 0 0 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA79652.1 - 8.8e-05 22.6 8.9 0.00022 21.3 8.9 1.7 1 0 0 1 1 1 1 B-box zinc finger DUF2383 PF09537.10 EFA79653.1 - 8e-14 51.9 0.1 1.6e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2383) Ferritin PF00210.24 EFA79653.1 - 0.0016 18.4 1.4 0.012 15.5 0.4 2.0 2 0 0 2 2 2 1 Ferritin-like domain DUF892 PF05974.12 EFA79653.1 - 0.013 15.5 0.3 0.09 12.8 0.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF892) zf-C3HC4_3 PF13920.6 EFA79654.1 - 3.4e-10 39.6 13.7 5.1e-10 39.1 13.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) WbqC PF08889.11 EFA79654.1 - 0.013 15.5 0.3 0.013 15.4 0.3 1.1 1 0 0 1 1 1 0 WbqC-like protein family DUF4279 PF14106.6 EFA79654.1 - 0.016 15.4 0.2 0.03 14.5 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4279) Prok-RING_4 PF14447.6 EFA79654.1 - 0.036 13.9 12.6 0.065 13.1 12.6 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFA79654.1 - 0.086 12.8 14.6 0.22 11.5 14.7 1.6 1 1 0 1 1 1 0 zinc-RING finger domain Med21 PF11221.8 EFA79654.1 - 0.16 12.3 2.9 1 9.6 0.9 2.1 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Cep57_MT_bd PF06657.13 EFA79654.1 - 0.24 11.9 4.0 1.6 9.3 1.5 2.4 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 KASH_CCD PF14662.6 EFA79654.1 - 1.1 9.0 9.9 4.4 7.1 2.8 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH zf-RING_2 PF13639.6 EFA79654.1 - 2.2 8.7 14.5 3.6 8.0 14.5 1.4 1 0 0 1 1 1 0 Ring finger domain Ank_2 PF12796.7 EFA79655.1 - 2.6e-61 204.2 19.3 3.1e-07 30.9 0.1 13.8 7 5 10 17 17 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79655.1 - 2.1e-57 190.8 28.8 9.4e-05 22.9 0.1 21.3 13 9 8 21 21 21 15 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79655.1 - 4.3e-36 122.5 9.0 0.19 12.1 0.0 22.7 12 7 15 27 27 27 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79655.1 - 2e-28 95.2 22.5 0.99 10.2 0.0 25.3 32 1 1 33 33 29 5 Ankyrin repeat DUF3447 PF11929.8 EFA79655.1 - 0.0035 17.3 64.7 0.44 10.5 2.4 15.0 9 2 6 15 15 15 4 Domain of unknown function (DUF3447) Cas9_Topo PF17894.1 EFA79655.1 - 0.0058 16.7 0.0 19 5.4 0.0 5.1 4 0 0 4 4 4 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 Helicase_PWI PF18149.1 EFA79655.1 - 0.01 16.0 16.4 0.11 12.6 0.0 6.4 8 1 0 8 8 8 2 N-terminal helicase PWI domain Herpes_PAP PF03325.13 EFA79655.1 - 0.025 14.2 0.3 2.8 7.5 0.0 3.3 3 0 0 3 3 3 0 Herpesvirus polymerase accessory protein Ank PF00023.30 EFA79655.1 - 0.073 13.6 4.4 4e+02 1.7 0.0 7.8 9 1 0 9 9 9 0 Ankyrin repeat EpCAM_N PF18635.1 EFA79655.1 - 0.12 12.6 1.4 0.71 10.1 0.1 2.6 2 0 0 2 2 2 0 Epithelial cell adhesion molecule N-terminal domain Xin PF08043.12 EFA79655.1 - 7.9 6.3 16.7 11 5.8 0.0 6.7 6 0 0 6 6 6 0 Xin repeat NUC194 PF08163.12 EFA79656.1 - 3.8e-68 230.2 12.0 3.8e-68 230.2 12.0 2.9 2 0 0 2 2 2 1 NUC194 domain PI3_PI4_kinase PF00454.27 EFA79656.1 - 1e-51 176.2 0.1 4.7e-51 174.0 0.1 2.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EFA79656.1 - 2.3e-20 73.1 5.6 5.3e-20 71.9 2.8 2.7 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 EFA79656.1 - 9.2e-11 41.4 0.6 2.8e-10 39.8 0.6 1.9 1 0 0 1 1 1 1 FATC domain RNA_pol_3_Rpc31 PF11705.8 EFA79656.1 - 2.4 8.3 17.0 5.1 7.3 15.3 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CobT PF06213.12 EFA79656.1 - 8.3 5.7 14.4 22 4.3 14.4 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Kelch_6 PF13964.6 EFA79657.1 - 2.3e-13 49.9 4.6 6.3e-07 29.5 0.1 4.7 3 1 1 4 4 4 2 Kelch motif zf-B_box PF00643.24 EFA79657.1 - 4.3e-06 26.8 5.9 4.3e-06 26.8 5.9 2.4 2 0 0 2 2 2 1 B-box zinc finger Kelch_3 PF13415.6 EFA79657.1 - 0.0011 19.2 0.2 0.9 9.9 0.0 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA79657.1 - 0.0029 17.6 6.0 8.8 6.4 0.3 4.6 4 1 0 4 4 4 2 Galactose oxidase, central domain Cep57_CLD PF14073.6 EFA79657.1 - 0.0094 16.0 10.8 0.021 14.8 10.8 1.6 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 Kelch_6 PF13964.6 EFA79658.1 - 5.6e-13 48.7 12.7 3.8e-05 23.8 0.1 5.9 5 1 1 6 6 6 3 Kelch motif zf-B_box PF00643.24 EFA79658.1 - 3.1e-08 33.6 5.8 6.2e-08 32.7 5.8 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA79658.1 - 8.7e-06 25.9 0.5 0.94 9.9 0.1 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA79658.1 - 0.00044 20.2 6.6 1.1 9.3 0.1 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Cep57_CLD PF14073.6 EFA79658.1 - 0.0041 17.2 7.3 0.0065 16.5 7.3 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 APG6_N PF17675.1 EFA79658.1 - 0.47 11.0 6.5 0.87 10.1 6.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Kelch_5 PF13854.6 EFA79658.1 - 0.63 10.1 4.7 1.6 8.8 0.3 3.4 3 0 0 3 3 3 0 Kelch motif Nas2_N PF18265.1 EFA79658.1 - 1.2 9.1 6.3 1.3 9.0 2.9 2.8 3 1 0 3 3 3 0 Nas2 N_terminal domain Streptin-Immun PF11083.8 EFA79658.1 - 2 8.9 13.5 1.9 8.9 2.7 3.4 2 1 0 3 3 3 0 Lantibiotic streptin immunity protein Kelch_6 PF13964.6 EFA79660.1 - 5.3e-12 45.6 12.8 7.2e-06 26.1 0.3 5.6 4 1 1 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA79660.1 - 6.9e-05 22.9 10.2 0.00033 20.7 10.2 2.2 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA79660.1 - 0.0031 17.8 0.2 1.6 9.1 0.0 3.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA79660.1 - 0.13 12.2 3.6 0.22 11.5 1.2 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA79660.1 - 0.21 11.6 9.1 5.7 7.0 0.2 4.5 4 0 0 4 4 4 0 Galactose oxidase, central domain Gp_dh_N PF00044.24 EFA79660.1 - 0.28 11.5 0.1 0.28 11.5 0.1 3.3 3 1 1 4 4 4 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Kelch_1 PF01344.25 EFA79660.1 - 0.66 9.6 4.6 3.3 7.4 0.2 3.9 4 0 0 4 4 4 0 Kelch motif DAPDH_C PF16654.5 EFA79660.1 - 9.6 6.0 8.9 17 5.2 1.0 2.5 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain Kelch_6 PF13964.6 EFA79661.1 - 7.5e-11 41.9 13.9 2.2e-06 27.8 0.1 5.6 6 1 1 7 7 7 2 Kelch motif zf-B_box PF00643.24 EFA79661.1 - 1.7e-05 24.9 5.8 4.5e-05 23.5 5.8 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA79661.1 - 2e-05 24.7 0.1 0.16 12.3 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA79661.1 - 0.002 18.1 3.3 6.2 6.9 0.1 4.0 3 0 0 3 3 3 2 Galactose oxidase, central domain tRNA_anti-codon PF01336.25 EFA79661.1 - 0.09 12.8 0.1 0.28 11.2 0.1 1.8 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Cep57_CLD PF14073.6 EFA79661.1 - 0.64 10.0 9.4 0.63 10.1 7.8 1.8 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 Kelch_5 PF13854.6 EFA79661.1 - 1.2 9.2 3.0 5 7.2 0.3 2.9 3 0 0 3 3 3 0 Kelch motif GDP_Man_Dehyd PF16363.5 EFA79662.1 - 4.8e-29 101.8 0.0 5.2e-29 101.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase TAA-Trp-ring PF15401.6 EFA79662.1 - 0.034 14.6 0.3 0.066 13.7 0.1 1.6 2 0 0 2 2 2 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin Kelch_6 PF13964.6 EFA79663.1 - 1.2e-12 47.6 7.2 2.3e-05 24.5 0.1 5.1 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA79663.1 - 1.7e-05 24.9 8.8 5e-05 23.4 8.8 1.9 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA79663.1 - 8e-05 22.6 3.3 1.4 9.0 0.1 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA79663.1 - 0.011 16.0 0.5 0.44 10.9 0.0 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA79663.1 - 0.62 10.1 2.5 2.8 8.0 0.2 2.7 2 0 0 2 2 2 0 Kelch motif Phasin PF05597.11 EFA79663.1 - 4.9 7.2 7.0 3.5 7.6 1.1 2.3 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) GDP_Man_Dehyd PF16363.5 EFA79664.1 - 5.9e-153 509.1 0.0 6.8e-153 508.9 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA79664.1 - 6.4e-73 245.2 0.0 8.1e-73 244.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA79664.1 - 0.003 16.7 0.0 0.0045 16.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 EFA79664.1 - 0.0054 16.3 0.0 0.0095 15.5 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EFA79664.1 - 0.011 14.9 0.0 0.037 13.2 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Oxysterol_BP PF01237.18 EFA79665.1 - 9.2e-109 363.7 0.3 1.2e-108 363.4 0.3 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein zf-MYND PF01753.18 EFA79666.1 - 6e-08 32.6 19.3 1.1e-07 31.8 19.3 1.5 1 0 0 1 1 1 1 MYND finger PolC_DP2 PF03833.13 EFA79666.1 - 3 5.6 6.6 3.3 5.4 6.6 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 SAM_PNT PF02198.16 EFA79667.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain GSCFA PF08885.11 EFA79667.1 - 0.088 12.4 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 GSCFA family DUF2551 PF10826.8 EFA79668.1 - 0.048 13.9 0.6 0.45 10.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2551) Cas_Csy4 PF09618.10 EFA79668.1 - 0.063 13.4 2.4 0.081 13.1 2.4 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) DUF4407 PF14362.6 EFA79668.1 - 0.24 10.7 1.9 0.32 10.3 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Jak1_Phl PF17887.1 EFA79668.1 - 0.31 11.0 7.3 0.27 11.2 6.1 1.5 1 1 0 1 1 1 0 Jak1 pleckstrin homology-like domain Pre-PUA PF17832.1 EFA79668.1 - 0.34 11.6 6.6 5.5 7.7 0.1 2.1 2 0 0 2 2 2 0 Pre-PUA-like domain DNA_pol_delta_4 PF04081.13 EFA79668.1 - 0.34 11.2 7.3 0.52 10.7 7.3 1.2 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 ATP-synt_E PF05680.12 EFA79668.1 - 1.4 9.3 8.5 0.71 10.2 6.4 1.5 2 0 0 2 2 2 0 ATP synthase E chain CLN3 PF02487.17 EFA79668.1 - 2.6 7.0 3.6 3.3 6.7 3.6 1.1 1 0 0 1 1 1 0 CLN3 protein RhoGEF PF00621.20 EFA79670.1 - 4.4e-50 170.5 0.4 1.2e-49 169.0 0.4 1.8 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EFA79670.1 - 5.5e-19 68.1 5.8 5.5e-19 68.1 5.8 2.0 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.29 EFA79670.1 - 0.00011 22.6 0.0 0.00039 20.9 0.0 2.0 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.16 EFA79670.1 - 0.0069 16.6 2.8 0.0069 16.6 2.8 2.1 2 0 0 2 2 2 1 FYVE-type zinc finger Glyco_hydro_19 PF00182.19 EFA79673.1 - 4.6e-40 138.0 16.2 5.5e-40 137.7 10.4 3.2 2 1 0 2 2 2 1 Chitinase class I DEC1 PF15859.5 EFA79673.1 - 0.0054 16.7 1.7 3 7.9 0.0 3.6 3 1 1 4 4 4 2 Deleted in esophageal cancer 1 family Bacillus_PapR PF05968.11 EFA79673.1 - 0.033 14.0 0.1 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Bacillus PapR protein Tmp39 PF10271.9 EFA79673.1 - 0.19 10.7 1.6 10 5.0 0.1 2.1 2 0 0 2 2 2 0 Putative transmembrane protein DUF1899 PF08953.11 EFA79673.1 - 4.4 7.3 6.9 6.9 6.6 0.3 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF1899) PH PF00169.29 EFA79674.1 - 1.8e-12 47.7 1.4 4.4e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 PH domain Peptidase_M66 PF10462.9 EFA79675.1 - 2.7e-58 197.3 1.7 2.7e-58 197.3 1.7 1.8 2 1 0 2 2 2 1 Peptidase M66 Astacin PF01400.24 EFA79675.1 - 0.0068 16.0 0.0 0.022 14.4 0.0 1.8 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 EFA79675.1 - 0.03 14.2 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Matrixin Reprolysin_3 PF13582.6 EFA79675.1 - 0.075 13.6 0.0 0.075 13.6 0.0 3.1 2 1 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like GREB1 PF15782.5 EFA79675.1 - 9.3 3.2 17.1 12 2.8 17.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SNARE PF05739.19 EFA79676.1 - 1.6e-10 40.8 0.2 3.9e-10 39.6 0.2 1.7 1 0 0 1 1 1 1 SNARE domain Prominin PF05478.11 EFA79676.1 - 0.0011 17.0 4.2 0.0011 17.0 4.2 2.3 2 1 1 3 3 3 1 Prominin Syntaxin PF00804.25 EFA79676.1 - 0.0045 16.7 15.2 0.037 13.7 15.2 2.2 1 1 0 1 1 1 1 Syntaxin DUF4164 PF13747.6 EFA79676.1 - 0.084 13.2 2.4 0.12 12.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DASH_Dad1 PF08649.10 EFA79676.1 - 1.6 9.0 5.7 3.5 7.9 0.5 3.1 3 0 0 3 3 3 0 DASH complex subunit Dad1 Auto_anti-p27 PF06677.12 EFA79677.1 - 6.8e-26 90.2 10.1 3.5e-14 52.7 1.2 2.3 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Ribosomal_S27e PF01667.17 EFA79677.1 - 0.067 12.9 2.0 0.074 12.8 0.4 1.8 2 0 0 2 2 2 0 Ribosomal protein S27 Lin-8 PF03353.15 EFA79677.1 - 1.8 8.1 21.1 0.8 9.2 5.6 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Coa1 PF08695.10 EFA79679.1 - 0.002 17.8 0.1 0.055 13.2 0.0 2.4 2 0 0 2 2 2 2 Cytochrome oxidase complex assembly protein 1 Pkinase PF00069.25 EFA79680.1 - 2.4e-73 246.7 0.0 7.3e-73 245.2 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79680.1 - 2e-33 115.8 0.1 5.6e-33 114.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase SCAPER_N PF16501.5 EFA79680.1 - 1.5e-05 24.9 0.5 0.00014 21.8 0.0 2.5 2 0 0 2 2 2 1 S phase cyclin A-associated protein in the endoplasmic reticulum Kdo PF06293.14 EFA79680.1 - 4.2e-05 23.0 0.4 0.0002 20.8 0.1 2.1 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2_jaz PF12171.8 EFA79680.1 - 0.0034 17.6 0.4 0.025 14.9 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFA79680.1 - 0.17 12.3 0.7 0.69 10.4 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-U1 PF06220.12 EFA79680.1 - 0.73 9.7 4.4 0.17 11.7 0.4 2.1 2 0 0 2 2 2 0 U1 zinc finger Rtt106 PF08512.12 EFA79681.1 - 0.02 15.3 1.8 7.4 7.1 0.0 3.7 3 0 0 3 3 3 0 Histone chaperone Rttp106-like HP0268 PF18618.1 EFA79681.1 - 0.044 14.2 4.3 0.15 12.5 4.3 1.8 1 0 0 1 1 1 0 HP0268 Ras PF00071.22 EFA79682.1 - 1.3e-58 197.2 0.1 1.5e-58 197.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA79682.1 - 1e-20 74.1 0.0 1.6e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA79682.1 - 2.5e-09 36.8 0.0 3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA79682.1 - 1.2e-06 28.2 0.3 1e-05 25.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA79682.1 - 0.00014 21.9 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFA79682.1 - 0.0028 17.5 1.1 0.028 14.2 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFA79682.1 - 0.0032 17.4 0.5 0.69 9.8 0.3 2.4 1 1 2 3 3 3 2 RsgA GTPase Septin PF00735.18 EFA79682.1 - 0.022 14.0 0.1 0.047 13.0 0.0 1.6 2 0 0 2 2 2 0 Septin Kelch_6 PF13964.6 EFA79683.1 - 2.2e-08 34.1 6.0 0.00033 20.8 0.1 5.0 5 1 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 EFA79683.1 - 1.1e-05 25.6 0.1 0.024 14.9 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain zf-B_box PF00643.24 EFA79683.1 - 8.4e-05 22.6 8.7 0.00018 21.5 8.7 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA79683.1 - 0.039 14.0 4.8 13 5.9 0.0 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain DUF5074 PF16819.5 EFA79683.1 - 0.054 13.5 5.7 0.47 10.5 0.1 3.4 1 1 3 4 4 4 0 Domain of unknown function (DUF5074) ubiquitin PF00240.23 EFA79684.1 - 1.4e-12 47.1 2.4 1.9e-11 43.5 0.1 2.7 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.8 EFA79684.1 - 3e-06 27.0 2.1 3.1e-05 23.7 0.0 2.7 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like GABP-alpha PF11620.8 EFA79684.1 - 0.0068 16.6 0.1 0.013 15.7 0.1 1.5 1 0 0 1 1 1 1 GA-binding protein alpha chain Ald_Xan_dh_C2 PF02738.18 EFA79684.1 - 0.042 12.3 0.0 0.054 11.9 0.0 1.1 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase Glyco_hydro_18 PF00704.28 EFA79685.1 - 1.6e-51 176.0 0.0 2.2e-51 175.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFA79685.1 - 7.1e-13 48.4 0.0 2.1e-06 27.7 0.0 2.6 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EFA79685.1 - 4.7e-08 33.4 10.0 4.7e-08 33.4 10.0 2.5 2 0 0 2 2 2 1 Chitin recognition protein DNase_NucA_NucB PF14040.6 EFA79685.1 - 2.6e-05 24.6 0.1 0.00018 21.9 0.1 2.1 2 0 0 2 2 2 1 Deoxyribonuclease NucA/NucB EF-hand_7 PF13499.6 EFA79686.1 - 1e-18 67.5 8.6 9.4e-13 48.4 0.8 3.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFA79686.1 - 1.1e-17 62.2 9.2 1.3e-05 24.4 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFA79686.1 - 5.5e-14 51.7 7.0 3.8e-08 33.0 1.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFA79686.1 - 8.6e-12 44.0 14.2 0.00019 21.1 0.0 4.5 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EFA79686.1 - 9.3e-09 34.4 6.8 0.012 15.0 0.2 4.0 3 0 0 3 3 3 3 EF hand TSC22 PF01166.18 EFA79686.1 - 0.00017 21.9 9.2 0.00037 20.8 1.2 12.3 7 3 4 11 11 11 2 TSC-22/dip/bun family Laminin_II PF06009.12 EFA79686.1 - 0.00044 20.3 18.0 0.00044 20.3 18.0 8.1 2 2 6 8 8 8 3 Laminin Domain II EF-hand_9 PF14658.6 EFA79686.1 - 0.00071 19.8 0.2 0.019 15.3 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain rve_3 PF13683.6 EFA79686.1 - 0.64 9.8 3.5 18 5.2 0.0 3.6 2 0 0 2 2 2 0 Integrase core domain BioY PF02632.14 EFA79687.1 - 2e-38 131.5 18.1 2e-38 131.5 18.1 1.5 2 0 0 2 2 2 1 BioY family DUF3382 PF11862.8 EFA79687.1 - 0.1 12.8 6.0 7.4 6.9 2.6 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3382) GATA PF00320.27 EFA79688.1 - 2.1e-16 59.2 6.1 5.5e-16 57.9 6.1 1.8 1 0 0 1 1 1 1 GATA zinc finger zf-RING_9 PF13901.6 EFA79690.1 - 4.1e-56 190.2 14.6 8.9e-56 189.1 14.6 1.6 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.19 EFA79690.1 - 2e-18 66.6 0.0 1.6e-17 63.8 0.0 2.6 2 0 0 2 2 2 1 RUN domain DnaJ_CXXCXGXG PF00684.19 EFA79690.1 - 0.5 10.8 14.3 0.46 10.9 7.9 2.8 2 0 0 2 2 2 0 DnaJ central domain Mu-like_Com PF10122.9 EFA79690.1 - 0.6 9.6 3.2 1.6 8.3 3.2 1.7 1 0 0 1 1 1 0 Mu-like prophage protein Com zf-C3H2C3 PF17122.5 EFA79690.1 - 1.7 8.8 7.4 0.61 10.2 2.3 2.7 2 0 0 2 2 2 0 Zinc-finger Ufm1 PF03671.14 EFA79691.1 - 3.1e-42 142.5 0.1 3.5e-42 142.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein DHHC PF01529.20 EFA79692.1 - 3.9 7.6 11.3 0.45 10.6 2.8 2.3 2 1 0 2 2 2 0 DHHC palmitoyltransferase GST_C_3 PF14497.6 EFA79694.1 - 2.4e-19 69.4 0.0 3.7e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA79694.1 - 4.3e-07 30.2 0.0 8.1e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA79694.1 - 9.6e-06 25.7 0.0 1.4e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA79694.1 - 2e-05 24.5 0.1 4.3e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA79694.1 - 0.0014 18.9 0.0 0.0026 18.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MaoC_dehydrat_N PF13452.6 EFA79694.1 - 0.067 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase SET PF00856.28 EFA79695.1 - 1.3e-09 38.7 0.1 1.1e-08 35.7 0.0 2.5 2 1 0 2 2 2 1 SET domain Macoilin PF09726.9 EFA79695.1 - 0.084 11.4 7.2 0.11 11.0 7.2 1.2 1 0 0 1 1 1 0 Macoilin family Hph PF13694.6 EFA79695.1 - 0.8 10.0 16.4 0.084 13.2 8.8 2.3 2 0 0 2 2 2 0 Sec63/Sec62 complex-interacting family E1-E2_ATPase PF00122.20 EFA79696.1 - 0.61 9.6 3.1 0.28 10.7 0.2 1.7 1 1 1 2 2 2 0 E1-E2 ATPase DUF2070 PF09843.9 EFA79696.1 - 2.9 6.1 9.3 3.7 5.7 9.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DHHC PF01529.20 EFA79696.1 - 5.3 7.1 8.7 15 5.7 8.5 1.7 1 1 1 2 2 2 0 DHHC palmitoyltransferase IRK PF01007.20 EFA79696.1 - 8.5 6.2 11.2 0.6 9.9 2.3 2.1 1 1 1 2 2 2 0 Inward rectifier potassium channel transmembrane domain RTA1 PF04479.13 EFA79697.1 - 3.9e-22 78.9 13.2 3.9e-22 78.9 13.2 2.0 2 0 0 2 2 2 1 RTA1 like protein DUF3377 PF11857.8 EFA79697.1 - 0.0056 16.6 9.1 0.45 10.5 0.0 4.0 4 1 0 4 4 4 2 Domain of unknown function (DUF3377) MLANA PF14991.6 EFA79697.1 - 0.012 15.9 3.9 1.1 9.6 1.1 2.5 2 0 0 2 2 2 0 Protein melan-A DUF4231 PF14015.6 EFA79697.1 - 0.016 15.7 0.3 0.016 15.7 0.3 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) SPC25 PF06703.11 EFA79697.1 - 0.31 10.8 11.5 0.86 9.4 1.7 2.5 2 1 1 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Kelch_6 PF13964.6 EFA79698.1 - 1e-08 35.1 1.2 0.00084 19.5 0.1 3.7 3 0 0 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA79698.1 - 1.9e-06 27.9 8.2 5.1e-06 26.5 8.2 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA79698.1 - 0.13 11.9 0.1 5.1 6.8 0.0 3.0 2 0 0 2 2 2 0 Kelch motif SnoaL_2 PF12680.7 EFA79699.1 - 7.5e-05 23.3 0.0 8.7e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFA79699.1 - 0.041 14.3 0.0 0.042 14.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DDE_Tnp_1_7 PF13843.6 EFA79700.1 - 5.5e-60 203.5 5.7 3.8e-51 174.4 1.0 2.1 1 1 1 2 2 2 2 Transposase IS4 SnoaL_2 PF12680.7 EFA79701.1 - 4.8e-05 23.9 0.0 5.5e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF3271 PF11675.8 EFA79701.1 - 0.012 14.9 2.5 0.012 14.8 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3271) DUF4440 PF14534.6 EFA79701.1 - 0.03 14.7 0.0 0.03 14.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) EF1G PF00647.19 EFA79702.1 - 7.3e-45 151.4 0.2 1.5e-44 150.4 0.2 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EFA79702.1 - 3.1e-13 49.7 0.9 6.2e-13 48.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA79702.1 - 7.9e-13 48.6 0.0 1.9e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA79702.1 - 6.6e-09 35.7 0.1 1.3e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA79702.1 - 9.7e-07 28.9 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA79702.1 - 1.1e-06 29.0 0.0 2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA79702.1 - 2.3e-05 24.6 0.0 5.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_5 PF18485.1 EFA79702.1 - 0.025 14.9 0.0 0.061 13.7 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain APG12 PF04110.13 EFA79703.1 - 6e-28 97.1 0.2 7.5e-28 96.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EFA79703.1 - 2.6e-07 30.8 0.0 3.1e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Auxin_repressed PF05564.12 EFA79703.1 - 0.044 14.5 0.0 0.51 11.0 0.1 2.0 2 0 0 2 2 2 0 Dormancy/auxin associated protein Thump_like PF18096.1 EFA79703.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 THUMP domain-like DUF4922 PF16269.5 EFA79704.1 - 0.013 15.3 0.4 1 9.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4922) Sulfotransfer_2 PF03567.14 EFA79705.1 - 8.3e-09 35.7 0.8 1.5e-08 34.8 0.5 1.6 1 1 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 EFA79705.1 - 2.6e-05 23.3 0.0 5.6e-05 22.2 0.0 1.4 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 EFA79705.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase domain DUF4094 PF13334.6 EFA79705.1 - 0.15 12.4 0.0 0.58 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) SHOCT PF09851.9 EFA79706.1 - 0.025 14.3 0.2 0.048 13.4 0.2 1.4 1 0 0 1 1 1 0 Short C-terminal domain EMP24_GP25L PF01105.24 EFA79707.1 - 7.6e-53 179.2 0.0 8.9e-53 178.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 EFA79707.1 - 0.028 14.6 0.0 0.058 13.6 0.0 1.6 1 1 0 1 1 1 0 SdrD B-like domain DUF3568 PF12092.8 EFA79707.1 - 0.044 13.9 0.8 1.9 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) CarboxypepD_reg PF13620.6 EFA79707.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain AhpC-TSA PF00578.21 EFA79708.1 - 7.3e-18 64.7 0.0 1e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 EFA79708.1 - 1.2e-06 28.2 0.0 2.8e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 EFA79708.1 - 3.1e-06 27.0 0.0 4.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin Lant_dehydr_N PF04738.13 EFA79708.1 - 0.3 9.1 0.0 1.7 6.7 0.0 1.8 2 0 0 2 2 2 0 Lantibiotic dehydratase, N terminus AhpC-TSA PF00578.21 EFA79709.1 - 3.3e-29 101.3 0.0 4.5e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFA79709.1 - 6.7e-10 38.9 0.0 9.2e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFA79709.1 - 2.2e-07 30.6 0.1 2.2e-07 30.6 0.1 2.1 3 0 0 3 3 3 1 C-terminal domain of 1-Cys peroxiredoxin SnoaL_2 PF12680.7 EFA79710.1 - 4.2e-05 24.1 0.0 4.9e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF3271 PF11675.8 EFA79710.1 - 0.015 14.6 1.8 0.017 14.4 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3271) DUF4440 PF14534.6 EFA79710.1 - 0.023 15.1 0.0 0.024 15.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Apt1 PF10351.9 EFA79711.1 - 0.052 12.4 22.0 0.015 14.1 15.9 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain Utp14 PF04615.13 EFA79711.1 - 0.16 10.5 31.7 0.29 9.7 22.1 2.0 2 0 0 2 2 2 0 Utp14 protein GREB1 PF15782.5 EFA79711.1 - 0.64 7.1 18.7 1.2 6.1 13.5 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 EFA79711.1 - 2.9 7.4 26.8 0.26 10.8 12.8 2.3 1 1 0 2 2 2 0 Spt20 family DUF3246 PF11596.8 EFA79711.1 - 6.8 6.0 20.2 8.9 5.7 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) SnoaL_2 PF12680.7 EFA79712.1 - 4.2e-05 24.1 0.0 4.9e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF3271 PF11675.8 EFA79712.1 - 0.01 15.1 1.8 0.011 15.0 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3271) DUF4440 PF14534.6 EFA79712.1 - 0.023 15.1 0.0 0.024 15.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) CutA1 PF03091.15 EFA79714.1 - 0.0022 17.8 1.4 0.0034 17.2 1.4 1.2 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein P-II PF00543.22 EFA79714.1 - 0.014 16.0 0.0 0.02 15.5 0.0 1.2 1 0 0 1 1 1 0 Nitrogen regulatory protein P-II CBM_20 PF00686.19 EFA79715.1 - 2.2e-18 66.0 0.8 4.4e-18 65.0 0.8 1.5 1 0 0 1 1 1 1 Starch binding domain ALP_N PF17989.1 EFA79715.1 - 0.12 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Actin like proteins N terminal domain Myotub-related PF06602.14 EFA79716.1 - 3.5e-31 108.4 0.2 3.5e-31 108.4 0.2 3.4 2 2 1 3 3 3 1 Myotubularin-like phosphatase domain RhoGAP PF00620.27 EFA79716.1 - 1.5e-20 73.6 0.2 3.2e-20 72.5 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain Vps36_ESCRT-II PF11605.8 EFA79716.1 - 0.06 13.5 2.8 0.09 13.0 0.1 2.7 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 Pkinase_Tyr PF07714.17 EFA79717.1 - 1.3e-51 175.4 0.0 2.1e-51 174.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA79717.1 - 5e-44 150.6 0.0 9.1e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 EFA79717.1 - 6.2e-07 29.4 0.1 2.1e-05 24.5 0.1 2.5 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Kdo PF06293.14 EFA79717.1 - 0.022 14.1 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gemini_V2 PF01524.17 EFA79717.1 - 0.1 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Geminivirus V2 protein APH PF01636.23 EFA79717.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SUIM_assoc PF16619.5 EFA79718.1 - 0.0041 17.1 1.7 0.0041 17.1 1.7 4.1 4 0 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 Roughex PF06020.11 EFA79718.1 - 0.29 10.2 13.5 0.31 10.1 6.0 2.6 2 0 0 2 2 2 0 Drosophila roughex protein Zip PF02535.22 EFA79718.1 - 4.5 6.4 10.5 0.13 11.4 0.3 2.7 3 0 0 3 3 3 0 ZIP Zinc transporter Vps39_1 PF10366.9 EFA79718.1 - 8.1 6.8 8.5 3.1 8.1 0.0 3.7 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 Ank_2 PF12796.7 EFA79719.1 - 5.1e-10 39.8 8.1 8.8e-05 23.0 0.1 5.3 4 1 1 6 6 6 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79719.1 - 0.0005 20.3 4.0 7.5 7.5 0.0 7.5 8 0 0 8 8 8 1 Ankyrin repeat Ank_5 PF13857.6 EFA79719.1 - 0.0026 18.0 1.2 7.9 6.9 0.0 5.2 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79719.1 - 0.0046 17.5 10.2 0.04 14.5 0.1 6.0 6 2 3 9 9 9 2 Ankyrin repeats (many copies) Clathrin PF00637.20 EFA79719.1 - 0.43 10.5 6.1 4.7 7.1 0.0 3.4 2 2 2 4 4 4 0 Region in Clathrin and VPS DUF249 PF03158.13 EFA79719.1 - 1.1 9.0 13.0 0.56 9.9 0.3 4.7 4 1 1 5 5 5 0 Multigene family 530 protein Hist_deacetyl PF00850.19 EFA79720.1 - 6.4e-43 147.4 0.0 7.6e-43 147.1 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain BK_channel_a PF03493.18 EFA79721.1 - 1.2e-17 63.9 0.1 1.7e-16 60.2 0.0 2.7 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 EFA79721.1 - 9.3e-11 41.4 4.5 2e-10 40.3 4.5 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EFA79721.1 - 2.5e-10 40.2 2.3 6.2e-10 38.9 2.3 1.7 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 EFA79721.1 - 1.8e-05 25.0 0.0 0.065 13.5 0.0 2.5 2 0 0 2 2 2 2 TrkA-N domain TrkA_C PF02080.21 EFA79721.1 - 0.0023 17.7 0.0 1.4 8.8 0.0 2.9 2 1 0 2 2 2 2 TrkA-C domain G-patch PF01585.23 EFA79722.1 - 1.3e-12 47.4 1.8 2.9e-12 46.3 1.8 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFA79722.1 - 0.017 15.2 1.0 0.017 15.2 1.0 3.7 3 0 0 3 3 3 0 G-patch domain H_lectin PF09458.10 EFA79723.1 - 1.2e-13 51.0 3.2 1.2e-13 51.0 1.2 2.1 2 1 0 2 2 2 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA79723.1 - 0.0044 17.1 0.4 0.01 16.0 0.4 1.8 1 1 0 1 1 1 1 F5/8 type C domain mRNA_cap_enzyme PF01331.19 EFA79724.1 - 4.3e-35 121.3 1.8 5.3e-35 121.0 0.4 1.9 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EFA79724.1 - 2.6e-13 50.6 0.4 1.3e-12 48.3 0.4 2.3 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EFA79724.1 - 1.6e-05 24.7 0.7 0.02 14.5 0.1 3.1 2 1 1 3 3 3 2 ATP dependent DNA ligase domain Pox_ATPase-GT PF10640.9 EFA79724.1 - 0.00039 19.4 2.5 0.0011 18.0 2.5 1.7 1 1 0 1 1 1 1 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase DUF5398 PF17376.2 EFA79724.1 - 0.014 16.0 0.1 0.045 14.4 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5398) Neur_chan_memb PF02932.16 EFA79724.1 - 0.03 14.4 2.7 0.058 13.4 2.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HSP20 PF00011.21 EFA79726.1 - 1.9e-25 89.0 0.1 2.3e-25 88.7 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA79726.1 - 5.2e-09 35.5 0.0 9.3e-09 34.7 0.0 1.5 1 0 0 1 1 1 1 HSP20-like domain found in ArsA WD40 PF00400.32 EFA79727.1 - 6.3e-20 71.1 14.1 0.00051 20.8 0.0 8.5 8 0 0 8 8 8 4 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 EFA79727.1 - 1.3e-12 47.3 10.3 2.9e-12 46.2 10.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ANAPC4_WD40 PF12894.7 EFA79727.1 - 2.1e-12 47.1 1.4 0.12 12.7 0.0 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4 PF00097.25 EFA79727.1 - 2.3e-09 37.0 11.0 6.9e-09 35.4 11.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFA79727.1 - 1.8e-08 34.4 9.3 7.1e-08 32.5 9.4 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFA79727.1 - 5.8e-08 32.9 9.8 1.6e-07 31.6 9.8 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA79727.1 - 1.3e-07 31.5 10.9 3.7e-07 30.1 10.9 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFA79727.1 - 1.4e-07 31.2 7.1 3.7e-07 29.9 7.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA79727.1 - 5.6e-06 26.2 10.0 1.8e-05 24.6 10.0 1.9 1 0 0 1 1 1 1 zinc-RING finger domain U-box PF04564.15 EFA79727.1 - 8.4e-05 22.7 0.1 0.00045 20.3 0.0 2.3 1 1 1 2 2 2 1 U-box domain zf-RING_6 PF14835.6 EFA79727.1 - 0.00021 21.1 3.3 0.00044 20.1 3.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EFA79727.1 - 0.00021 21.1 10.8 0.002 17.9 11.2 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EFA79727.1 - 0.0022 18.1 4.1 0.005 17.0 4.1 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EFA79727.1 - 0.0022 18.2 7.4 0.0022 18.2 7.4 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-Nse PF11789.8 EFA79727.1 - 0.02 14.7 6.6 0.048 13.5 6.6 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 EFA79727.1 - 0.27 11.0 8.2 0.87 9.4 8.2 2.0 1 0 0 1 1 1 0 RING-like zinc finger HTH_AraC PF00165.23 EFA79728.1 - 0.14 12.3 0.1 0.37 11.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family Presenilin PF01080.17 EFA79728.1 - 9 4.9 8.1 11 4.7 8.1 1.1 1 0 0 1 1 1 0 Presenilin C2 PF00168.30 EFA79729.1 - 3.3e-24 85.1 0.0 6.3e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.29 EFA79729.1 - 3.3e-09 37.2 0.3 1.2e-08 35.4 0.2 2.0 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 EFA79729.1 - 0.001 19.1 0.1 0.0022 18.1 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 EFA79729.1 - 0.0015 18.8 0.0 0.0029 17.9 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain DDE_3 PF13358.6 EFA79730.1 - 4e-16 59.1 0.1 7.2e-16 58.3 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 EFA79730.1 - 1.6e-11 44.6 2.6 2.8e-11 43.9 1.0 2.2 2 1 1 3 3 3 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EFA79730.1 - 4.6e-11 42.8 0.7 5e-10 39.5 0.2 2.4 2 0 0 2 2 2 1 Transposase HTH_29 PF13551.6 EFA79730.1 - 6.9e-09 35.6 2.2 1.3e-08 34.7 2.2 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 EFA79730.1 - 3.1e-06 27.2 0.6 3.1e-06 27.2 0.6 2.2 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_23 PF13384.6 EFA79730.1 - 6.4e-06 25.8 0.1 6.4e-06 25.8 0.1 2.8 4 0 0 4 4 2 1 Homeodomain-like domain HTH_Tnp_4 PF13613.6 EFA79730.1 - 0.00057 19.6 0.0 0.0018 18.0 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease HTH_33 PF13592.6 EFA79730.1 - 0.0018 17.9 0.5 0.0095 15.6 0.0 2.5 3 0 0 3 3 2 1 Winged helix-turn helix HTH_Crp_2 PF13545.6 EFA79730.1 - 0.0038 17.2 0.8 0.018 15.0 0.2 2.3 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 EFA79730.1 - 0.0059 16.1 0.7 0.023 14.3 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 EFA79730.1 - 0.01 15.7 0.1 0.032 14.2 0.1 1.8 1 0 0 1 1 1 0 HTH domain HTH_20 PF12840.7 EFA79730.1 - 0.012 15.6 0.1 0.19 11.8 0.1 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 EFA79730.1 - 0.015 14.9 0.7 1.7 8.4 0.0 3.5 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_38 PF13936.6 EFA79730.1 - 0.019 14.7 3.6 0.028 14.2 1.8 2.2 2 0 0 2 2 1 0 Helix-turn-helix domain HTH_17 PF12728.7 EFA79730.1 - 0.02 15.1 2.0 0.038 14.2 0.2 2.6 3 1 0 3 3 2 0 Helix-turn-helix domain PAX PF00292.18 EFA79730.1 - 0.023 14.6 0.6 0.036 14.0 0.6 1.3 1 0 0 1 1 1 0 'Paired box' domain GntR PF00392.21 EFA79730.1 - 0.026 14.2 0.1 0.13 12.0 0.1 2.1 1 1 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_psq PF05225.16 EFA79730.1 - 0.03 14.0 0.2 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_36 PF13730.6 EFA79730.1 - 0.05 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 EFA79730.1 - 0.055 13.1 0.1 0.15 11.7 0.1 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain MarR_2 PF12802.7 EFA79730.1 - 0.056 13.3 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 MarR family DUF668 PF05003.12 EFA79730.1 - 0.06 13.8 0.0 0.21 12.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF668) HTH_7 PF02796.15 EFA79730.1 - 0.07 13.2 0.1 0.07 13.2 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_26 PF13443.6 EFA79730.1 - 0.11 13.0 0.3 5.4 7.5 0.0 3.1 3 0 0 3 3 2 0 Cro/C1-type HTH DNA-binding domain Tti2 PF10521.9 EFA79730.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Tti2 family HTH_Tnp_ISL3 PF13542.6 EFA79730.1 - 0.25 10.8 2.6 0.32 10.4 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 RRM_1 PF00076.22 EFA79731.1 - 8e-16 57.6 0.1 1.1e-15 57.1 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFA79731.1 - 0.1 12.7 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Limkain b1 S4 PF01479.25 EFA79733.1 - 7.1e-08 32.0 0.1 1.2e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EFA79733.1 - 0.039 14.9 0.3 0.083 13.8 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S4/S9 N-terminal domain SnoaL_2 PF12680.7 EFA79734.1 - 0.0018 18.9 0.0 0.0022 18.6 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFA79734.1 - 0.12 12.7 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Mucin PF01456.17 EFA79735.1 - 0.0093 16.0 23.4 0.059 13.4 1.2 2.2 2 0 0 2 2 2 2 Mucin-like glycoprotein SPX PF03105.19 EFA79735.1 - 0.058 13.3 14.0 0.084 12.8 14.0 1.2 1 0 0 1 1 1 0 SPX domain Ank_5 PF13857.6 EFA79736.1 - 4.1e-12 46.1 0.1 1.3e-11 44.5 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA79736.1 - 1.3e-07 32.1 0.0 3.2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79736.1 - 4.5e-07 30.3 0.1 1.3e-06 28.9 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79736.1 - 1.5e-05 25.0 0.1 0.0001 22.4 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFA79736.1 - 5.9e-05 23.3 0.1 0.00018 21.8 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat DUF3439 PF11921.8 EFA79736.1 - 0.0055 16.7 0.4 0.0055 16.7 0.4 3.7 3 1 0 3 3 3 1 Domain of unknown function (DUF3439) BRCT PF00533.26 EFA79737.1 - 4.8e-23 81.3 8.8 1.2e-05 25.6 0.1 4.1 3 1 1 4 4 4 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA79737.1 - 7.4e-20 71.2 7.1 1.6e-10 41.2 0.1 3.7 3 1 1 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFA79737.1 - 2e-16 59.7 2.6 1.2e-07 31.6 0.1 4.2 4 0 0 4 4 4 3 twin BRCT domain LIG3_BRCT PF16759.5 EFA79737.1 - 8.4e-06 26.0 0.2 0.75 10.1 0.2 3.4 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EFA79737.1 - 0.0087 16.1 2.8 0.63 10.1 0.2 2.7 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain SEA PF01390.20 EFA79737.1 - 0.062 13.4 0.3 0.27 11.4 0.2 2.1 2 0 0 2 2 2 0 SEA domain PTE PF02126.18 EFA79738.1 - 1.9e-87 293.5 2.1 2.4e-87 293.2 2.1 1.1 1 0 0 1 1 1 1 Phosphotriesterase family YhfZ_C PF14503.6 EFA79738.1 - 0.015 14.9 0.2 0.025 14.1 0.2 1.3 1 0 0 1 1 1 0 YhfZ C-terminal domain TFIID-31kDa PF02291.15 EFA79738.1 - 0.041 14.0 0.3 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit EcKinase PF02958.20 EFA79738.1 - 0.064 12.6 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase T6_Ig_like PF18002.1 EFA79739.1 - 0.047 13.6 0.0 0.053 13.4 0.0 1.1 1 0 0 1 1 1 0 T6 antigen Ig like domain ABC2_membrane PF01061.24 EFA79741.1 - 9.6e-91 302.9 66.3 1.7e-49 168.1 27.6 2.5 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EFA79741.1 - 3.6e-39 134.4 0.0 1.4e-18 67.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFA79741.1 - 5e-30 103.3 4.1 5.7e-26 90.2 0.2 4.0 3 1 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EFA79741.1 - 2.7e-10 39.9 54.9 4.5e-09 35.9 17.2 3.3 2 1 1 3 3 3 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 EFA79741.1 - 3.2e-07 30.9 0.4 8.5e-07 29.5 0.4 1.7 1 1 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EFA79741.1 - 2.9e-06 27.3 0.1 0.00076 19.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EFA79741.1 - 8.6e-06 25.8 0.0 0.029 14.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA79741.1 - 1.1e-05 25.0 0.5 0.0043 16.8 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA79741.1 - 8e-05 23.1 0.0 0.018 15.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EFA79741.1 - 0.00029 20.5 0.1 0.0019 17.8 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFA79741.1 - 0.00045 20.5 0.0 0.32 11.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA79741.1 - 0.0057 16.4 0.3 1.7 8.4 0.4 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA79741.1 - 0.0065 17.0 0.0 0.25 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFA79741.1 - 0.0077 16.3 0.2 5.5 7.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_24 PF13479.6 EFA79741.1 - 0.038 13.7 0.0 0.39 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFA79741.1 - 0.049 13.5 0.0 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_28 PF13521.6 EFA79741.1 - 0.064 13.5 0.3 0.23 11.7 0.4 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFA79741.1 - 0.085 13.0 0.0 0.52 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFA79741.1 - 0.16 12.4 0.1 6.9 7.1 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EFA79741.1 - 0.21 11.1 0.4 2.5 7.6 0.3 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain EGF_2 PF07974.13 EFA79744.1 - 3.5e-05 24.1 5.8 8.8e-05 22.8 5.8 1.7 1 0 0 1 1 1 1 EGF-like domain DUF5305 PF17231.2 EFA79744.1 - 0.005 16.3 0.9 0.016 14.6 0.9 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Podoplanin PF05808.11 EFA79744.1 - 0.0054 16.8 0.2 0.011 15.8 0.2 1.4 1 0 0 1 1 1 1 Podoplanin DUF2613 PF11021.8 EFA79744.1 - 0.031 14.4 0.2 0.072 13.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) Laminin_EGF PF00053.24 EFA79744.1 - 0.42 10.8 4.5 0.84 9.8 4.5 1.4 1 0 0 1 1 1 0 Laminin EGF domain Pathogen_betaC1 PF09593.10 EFA79744.1 - 0.54 10.2 6.2 0.21 11.5 0.1 3.3 3 0 0 3 3 3 0 Beta-satellite pathogenicity beta C1 protein EGF_2 PF07974.13 EFA79745.1 - 3.3e-05 24.1 5.8 8.2e-05 22.9 5.8 1.7 1 0 0 1 1 1 1 EGF-like domain DUF3042 PF11240.8 EFA79745.1 - 0.028 14.4 0.1 0.33 11.0 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) Podoplanin PF05808.11 EFA79745.1 - 0.057 13.5 0.6 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Podoplanin DUF2613 PF11021.8 EFA79745.1 - 0.091 12.9 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) Laminin_EGF PF00053.24 EFA79745.1 - 0.38 10.9 4.5 0.79 9.9 4.5 1.5 1 0 0 1 1 1 0 Laminin EGF domain MRP-S23 PF10484.9 EFA79746.1 - 0.041 14.1 2.4 3.9 7.7 0.2 2.5 2 1 0 2 2 2 0 Mitochondrial ribosomal protein S23 TMEM210 PF15195.6 EFA79747.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 TMEM210 family DUF4912 PF16258.5 EFA79747.1 - 0.14 12.4 0.1 0.4 10.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4912) ADH_N_2 PF16884.5 EFA79749.1 - 7.1e-23 80.6 0.0 1.6e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFA79749.1 - 1.3e-17 64.0 0.0 1.8e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA79749.1 - 3.7e-08 34.5 0.0 6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DDOST_48kD PF03345.14 EFA79749.1 - 0.18 10.6 0.0 1.6 7.5 0.0 2.0 2 0 0 2 2 2 0 Oligosaccharyltransferase 48 kDa subunit beta Sec20 PF03908.13 EFA79752.1 - 0.0078 16.1 0.2 0.0078 16.1 0.2 2.4 2 0 0 2 2 2 1 Sec20 PIN_5 PF08745.11 EFA79752.1 - 0.054 12.9 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 PINc domain ribonuclease ALMT PF11744.8 EFA79752.1 - 0.094 11.5 9.2 0.15 10.9 9.2 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Tim54 PF11711.8 EFA79752.1 - 8.2 5.1 9.1 13 4.4 9.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NST1 PF13945.6 EFA79752.1 - 8.6 6.4 18.4 18 5.4 18.4 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator RVT_1 PF00078.27 EFA79753.1 - 1.7e-25 89.8 0.5 4.3e-25 88.5 0.5 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EFA79753.1 - 3.6e-23 81.9 0.6 1.1e-22 80.3 0.2 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA79753.1 - 2e-22 79.1 0.1 5.7e-22 77.6 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EFA79753.1 - 9.2e-17 60.9 0.2 9.2e-17 60.9 0.2 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EFA79753.1 - 9.1e-12 45.2 0.0 2.3e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Retrotrans_gag PF03732.17 EFA79753.1 - 0.0024 18.1 0.3 0.012 15.9 0.3 2.2 1 0 0 1 1 1 1 Retrotransposon gag protein zf-H2C2 PF09337.10 EFA79753.1 - 0.0065 16.7 1.7 0.0095 16.1 0.3 2.1 2 0 0 2 2 2 1 H2C2 zinc finger TPR_17 PF13431.6 EFA79755.1 - 3.2e-57 186.9 19.0 2.5e-09 36.8 0.1 10.3 9 1 1 10 10 10 10 Tetratricopeptide repeat TPR_11 PF13414.6 EFA79755.1 - 3.7e-13 48.9 22.9 0.16 11.7 0.3 9.1 8 1 1 9 9 9 7 TPR repeat DUF1153 PF06627.11 EFA79755.1 - 0.024 14.7 0.0 56 4.0 0.0 4.9 8 0 0 8 8 8 0 Protein of unknown function (DUF1153) TMEM131_like PF12371.8 EFA79755.1 - 0.048 13.9 3.6 3.9 7.8 0.1 4.3 3 2 3 6 6 6 0 Transmembrane protein 131-like NleF_casp_inhib PF16809.5 EFA79755.1 - 0.14 12.1 1.8 28 4.6 0.0 4.1 3 2 1 4 4 4 0 NleF caspase inhibitor DUF1344 PF07076.11 EFA79755.1 - 0.51 10.3 4.3 42 4.1 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF1344) ASXH PF13919.6 EFA79757.1 - 0.0063 16.5 0.4 0.0063 16.5 0.4 1.6 2 0 0 2 2 2 1 Asx homology domain CobT PF06213.12 EFA79757.1 - 0.016 14.6 0.4 0.021 14.2 0.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT UNC-93 PF05978.16 EFA79758.1 - 2.2e-25 89.2 13.7 2.2e-25 89.2 13.7 2.8 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EFA79758.1 - 3.9e-22 78.7 26.3 5.8e-22 78.1 26.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Mnd1 PF03962.15 EFA79759.1 - 1.2e-17 64.0 0.2 3.8e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 EFA79759.1 - 1.5e-15 57.0 3.2 1.5e-15 57.0 3.2 2.4 3 0 0 3 3 3 1 Leucine zipper with capping helix domain UPF0242 PF06785.11 EFA79759.1 - 0.06 13.4 4.6 0.098 12.7 4.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 EFA79760.1 - 0.011 15.8 1.1 0.024 14.7 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 EFA79760.1 - 0.076 12.6 5.2 0.1 12.2 5.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HMMR_N PF15905.5 EFA79760.1 - 0.11 12.0 5.5 0.17 11.3 5.5 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Sipho_Gp157 PF05565.11 EFA79760.1 - 0.12 12.4 5.2 0.2 11.6 4.9 1.5 1 1 0 1 1 1 0 Siphovirus Gp157 Fzo_mitofusin PF04799.13 EFA79760.1 - 0.13 11.8 1.6 0.22 11.1 1.1 1.7 1 1 0 1 1 1 0 fzo-like conserved region Fmp27_WPPW PF10359.9 EFA79760.1 - 0.17 10.7 12.5 0.0089 14.9 4.6 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain L31 PF09784.9 EFA79760.1 - 0.18 12.3 1.5 1.4 9.4 0.2 2.7 1 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 KxDL PF10241.9 EFA79760.1 - 2.8 8.3 8.3 0.62 10.4 2.3 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein YabA PF06156.13 EFA79760.1 - 3.9 8.2 10.1 0.38 11.4 3.6 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DUF5082 PF16888.5 EFA79760.1 - 4.8 7.5 19.7 2.1 8.6 14.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.12 EFA79760.1 - 9.7 6.2 35.8 27 4.8 35.8 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3915 PF13054.6 EFA79761.1 - 0.051 13.6 3.5 6.4 6.8 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) HEAT PF02985.22 EFA79762.1 - 1.3e-16 59.3 0.0 0.069 13.4 0.0 7.6 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.6 EFA79762.1 - 1.7e-13 50.8 0.0 0.00024 21.4 0.0 3.6 2 1 1 3 3 3 2 HEAT repeats Cnd1 PF12717.7 EFA79762.1 - 2.1e-07 31.1 12.5 0.011 15.8 1.0 4.4 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFA79762.1 - 7.8e-06 26.4 4.3 0.072 13.7 0.1 4.2 2 1 2 4 4 4 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 EFA79762.1 - 2.4e-05 24.5 1.5 0.081 13.1 0.0 4.1 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EFA79762.1 - 0.00033 21.1 0.0 3.9 8.1 0.0 4.3 5 1 0 5 5 3 2 HEAT-like repeat DUF2722 PF10846.8 EFA79762.1 - 0.00091 18.3 7.8 0.00091 18.3 7.8 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) MscS_TM PF12794.7 EFA79762.1 - 0.22 10.3 2.5 0.46 9.3 2.5 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TFIIA PF03153.13 EFA79762.1 - 0.96 9.4 32.8 0.02 14.9 10.2 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EFA79762.1 - 2.3 7.8 48.6 5.3 6.6 14.2 2.7 2 0 0 2 2 2 0 Spt20 family HrpB7 PF09486.10 EFA79762.1 - 3.5 8.0 10.1 0.28 11.5 4.5 1.9 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF4834 PF16118.5 EFA79762.1 - 3.6 8.6 25.2 0.13 13.2 4.5 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) ANAPC4_WD40 PF12894.7 EFA79763.1 - 9.2e-10 38.7 4.3 0.26 11.6 0.0 7.4 5 2 0 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain TFIIA PF03153.13 EFA79763.1 - 5.9 6.8 19.0 13 5.7 19.0 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Vps39_2 PF10367.9 EFA79764.1 - 3e-30 104.9 6.6 9e-30 103.3 0.2 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EFA79764.1 - 1e-12 48.1 1.7 1e-12 48.1 1.7 4.1 4 0 0 4 4 4 1 Region in Clathrin and VPS CNH PF00780.22 EFA79764.1 - 7.7e-10 38.8 0.2 9.5e-06 25.4 0.0 2.7 2 1 1 3 3 3 2 CNH domain Vps39_1 PF10366.9 EFA79764.1 - 0.00067 19.9 8.5 0.0096 16.2 0.1 4.2 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 DUF2175 PF09943.9 EFA79764.1 - 0.085 13.1 0.9 0.54 10.6 0.9 2.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Sporozoite_P67 PF05642.11 EFA79764.1 - 0.088 10.9 3.2 0.13 10.3 3.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Methyltransf_20 PF12147.8 EFA79764.1 - 0.17 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Zip PF02535.22 EFA79764.1 - 0.26 10.4 1.1 0.45 9.7 1.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TT_ORF1 PF02956.14 EFA79764.1 - 2.8 6.5 16.5 0.44 9.2 6.6 2.2 2 0 0 2 2 2 0 TT viral orf 1 POX PF07526.11 EFA79764.1 - 8 7.0 8.0 17 6.0 4.8 2.7 2 0 0 2 2 2 0 Associated with HOX Y_phosphatase3 PF13350.6 EFA79766.1 - 1.8e-38 132.8 0.0 7.9e-27 94.7 0.0 2.5 2 1 0 2 2 2 2 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EFA79766.1 - 1.6e-05 24.6 0.1 0.00034 20.2 0.0 2.7 2 1 1 3 3 3 1 Tyrosine phosphatase family SUIM_assoc PF16619.5 EFA79766.1 - 1.6e-05 24.8 0.0 6.3e-05 23.0 0.0 2.0 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF2457 PF10446.9 EFA79766.1 - 0.048 12.8 16.8 0.033 13.3 12.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) TFIIA PF03153.13 EFA79766.1 - 0.064 13.2 11.9 0.12 12.3 11.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 EFA79766.1 - 0.086 11.5 6.7 0.12 11.1 6.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 EFA79766.1 - 0.64 9.2 21.7 0.93 8.6 21.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein LRR_4 PF12799.7 EFA79767.1 - 0.009 16.4 0.2 0.009 16.4 0.2 2.7 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) DNA_pack_C PF02499.15 EFA79767.1 - 0.046 12.7 0.2 0.091 11.7 0.2 1.4 1 0 0 1 1 1 0 Probable DNA packing protein, C-terminus Abhydrolase_1 PF00561.20 EFA79768.1 - 1.6e-14 54.2 0.0 2.5e-10 40.4 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA79768.1 - 2.8e-10 39.9 0.0 4.3e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA79768.1 - 5.7e-05 23.8 0.0 0.0001 23.0 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EFA79768.1 - 0.00063 19.6 0.0 0.0017 18.2 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.18 EFA79768.1 - 0.013 15.1 0.0 0.38 10.3 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF915 PF06028.11 EFA79768.1 - 0.014 14.8 0.2 0.075 12.3 0.1 2.1 1 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.7 EFA79768.1 - 0.097 12.4 0.0 13 5.6 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase family Cutinase PF01083.22 EFA79768.1 - 0.1 12.6 0.0 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 Cutinase DUF829 PF05705.14 EFA79768.1 - 0.11 12.4 0.1 0.49 10.2 0.1 1.9 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) DUF2048 PF09752.9 EFA79768.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 1 0 1 1 1 0 Abhydrolase domain containing 18 DUF5600 PF18150.1 EFA79769.1 - 3.4e-42 143.3 0.7 3.4e-42 143.3 0.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 EFA79769.1 - 1.8e-20 72.8 0.0 5.4e-20 71.3 0.0 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 EFA79769.1 - 2.4e-14 52.9 0.1 5.7e-14 51.7 0.1 1.7 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 EFA79769.1 - 4.5e-12 46.3 0.0 8e-11 42.3 0.0 2.4 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFA79769.1 - 2.5e-07 30.8 0.0 5.9e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 EFA79769.1 - 0.00028 20.2 0.2 0.0011 18.3 0.2 2.2 1 0 0 1 1 1 1 EF hand Roc PF08477.13 EFA79769.1 - 0.0021 18.3 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFA79769.1 - 0.013 15.1 0.0 0.057 13.0 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain EF-hand_8 PF13833.6 EFA79769.1 - 0.031 14.1 0.1 0.094 12.6 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EFA79769.1 - 0.11 12.5 0.1 0.73 9.9 0.1 2.5 1 0 0 1 1 1 0 EF-hand domain TUDOR PF00567.24 EFA79770.1 - 2.4e-06 27.6 0.3 8.2e-06 25.9 0.0 2.1 2 1 1 3 3 3 1 Tudor domain SMN PF06003.12 EFA79770.1 - 7.5e-06 25.4 11.8 7.5e-06 25.4 11.8 2.7 1 1 1 2 2 2 1 Survival motor neuron protein (SMN) YscO-like PF16789.5 EFA79770.1 - 0.0036 17.4 1.2 0.0036 17.4 1.2 2.0 2 0 0 2 2 2 1 YscO-like protein Agenet PF05641.12 EFA79770.1 - 0.01 16.3 0.5 0.021 15.3 0.0 1.8 2 0 0 2 2 2 0 Agenet domain DUF2730 PF10805.8 EFA79770.1 - 0.038 14.1 6.5 0.072 13.2 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Fis1_TPR_C PF14853.6 EFA79770.1 - 3 8.0 5.1 0.84 9.8 0.9 2.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Sina PF03145.16 EFA79771.1 - 4.7e-10 39.7 1.8 6.7e-10 39.2 1.8 1.4 1 0 0 1 1 1 1 Seven in absentia protein family CDC45 PF02724.14 EFA79771.1 - 0.057 11.7 12.0 0.082 11.2 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 EFA79771.1 - 0.083 11.0 6.5 0.1 10.7 6.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CobT PF06213.12 EFA79771.1 - 0.098 12.0 11.6 0.14 11.6 11.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Radial_spoke PF04712.12 EFA79771.1 - 0.13 11.2 6.1 0.24 10.3 6.1 1.4 1 0 0 1 1 1 0 Radial spokehead-like protein Astro_capsid_p PF12226.8 EFA79771.1 - 0.14 11.3 6.2 0.22 10.7 6.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2457 PF10446.9 EFA79771.1 - 0.18 10.9 17.4 0.31 10.1 17.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 EFA79771.1 - 0.18 11.2 15.4 0.021 14.3 11.5 1.4 2 0 0 2 2 2 0 SDA1 TRAP_alpha PF03896.16 EFA79771.1 - 0.24 10.6 6.2 0.37 9.9 6.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.12 EFA79771.1 - 0.35 9.0 16.2 0.52 8.5 16.2 1.2 1 0 0 1 1 1 0 Nop14-like family GOLD_2 PF13897.6 EFA79771.1 - 0.53 10.8 4.6 1.3 9.5 4.6 1.6 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking BUD22 PF09073.10 EFA79771.1 - 0.78 9.0 15.1 1.2 8.4 15.1 1.2 1 0 0 1 1 1 0 BUD22 Sigma70_ner PF04546.13 EFA79771.1 - 0.87 9.4 12.6 1.6 8.6 12.6 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region FAM176 PF14851.6 EFA79771.1 - 0.9 9.2 10.7 0.074 12.7 5.9 1.7 2 0 0 2 2 2 0 FAM176 family DNA_pol_phi PF04931.13 EFA79771.1 - 1.2 7.1 23.3 2 6.4 23.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi RPN2_C PF18004.1 EFA79771.1 - 1.5 8.7 9.2 0.31 11.0 5.1 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain GEN1_C PF18380.1 EFA79771.1 - 1.9 9.4 8.4 4.5 8.2 8.4 1.5 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain PTPRCAP PF15713.5 EFA79771.1 - 2 8.7 15.9 0.53 10.6 12.6 1.6 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated TFB6 PF17110.5 EFA79771.1 - 9.9 5.9 8.5 18 5.0 8.5 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH AMP-binding PF00501.28 EFA79772.1 - 4.8e-48 163.8 0.0 6.6e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ZZ PF00569.17 EFA79772.1 - 0.76 9.6 8.8 1.7 8.5 8.8 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type AMP-binding PF00501.28 EFA79773.1 - 2.7e-46 158.0 0.0 3.8e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme HH_signal PF01085.18 EFA79774.1 - 0.0083 15.8 0.4 0.021 14.5 0.4 1.6 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain zf-FCS PF06467.14 EFA79774.1 - 0.094 12.7 8.7 0.35 10.8 4.5 2.7 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Phage_holin_2_4 PF16082.5 EFA79776.1 - 0.021 14.6 0.4 0.046 13.5 0.4 1.5 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like DUF3139 PF11337.8 EFA79776.1 - 0.075 13.7 3.2 5.2 7.8 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) Saf_2TM PF18303.1 EFA79776.1 - 0.11 12.1 0.3 0.18 11.4 0.3 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Myticin-prepro PF10690.9 EFA79776.1 - 0.14 12.4 0.4 0.14 12.4 0.4 1.8 1 1 1 2 2 2 0 Myticin pre-proprotein from the mussel DUF4307 PF14155.6 EFA79776.1 - 0.38 10.6 0.1 0.38 10.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) CitMHS PF03600.16 EFA79776.1 - 1.9 7.6 4.2 15 4.7 4.0 1.9 1 1 0 1 1 1 0 Citrate transporter DUF3149 PF11346.8 EFA79776.1 - 8.8 6.0 8.3 0.27 10.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) Dicty_spore_N PF04562.12 EFA79779.1 - 1.6e-07 32.0 5.6 1.6e-07 32.0 5.6 3.9 3 1 1 4 4 4 1 Dictyostelium spore coat protein, N terminus DUF5546 PF17700.1 EFA79779.1 - 0.017 15.5 0.6 0.053 13.9 0.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5546) Ydr279_N PF17745.1 EFA79779.1 - 0.14 12.4 0.6 0.89 9.9 0.2 2.4 2 1 0 2 2 2 0 Ydr279p protein triple barrel domain CytochromB561_N PF09786.9 EFA79780.1 - 1.2e-07 31.1 35.7 1.2e-07 31.1 35.7 3.6 2 1 0 2 2 2 1 Cytochrome B561, N terminal ACBP PF00887.19 EFA79781.1 - 2.5e-27 94.9 0.2 6.4e-27 93.6 0.2 1.7 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_2 PF12796.7 EFA79781.1 - 1.3e-13 51.4 0.1 2.3e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79781.1 - 3.5e-13 49.8 0.2 1.2e-07 32.1 0.1 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA79781.1 - 1.3e-11 44.3 0.4 2e-06 28.0 0.2 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFA79781.1 - 2.2e-10 40.6 0.1 1.1e-06 28.8 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79781.1 - 2.1e-07 30.7 0.1 0.0031 17.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Dicty_REP PF05086.12 EFA79781.1 - 0.047 11.7 8.3 0.059 11.4 8.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EFA79781.1 - 0.17 11.8 3.9 0.37 10.8 3.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) HsdM_N PF12161.8 EFA79781.1 - 0.72 10.5 4.4 0.24 12.0 1.1 2.0 2 1 0 2 2 2 0 HsdM N-terminal domain DUF4834 PF16118.5 EFA79781.1 - 1.9 9.5 4.7 4.2 8.4 4.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) eIF3_N PF09440.10 EFA79782.1 - 0.0055 17.1 0.7 0.034 14.6 0.3 2.6 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain RhoGAP PF00620.27 EFA79783.1 - 2.1e-28 99.0 0.2 3.5e-28 98.4 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain p450 PF00067.22 EFA79784.1 - 4.3e-67 226.9 0.0 5.2e-67 226.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C1 PF00112.23 EFA79785.1 - 1.8e-36 126.3 17.8 8.5e-22 78.3 0.6 2.9 2 1 1 3 3 3 2 Papain family cysteine protease zf-RING_UBOX PF13445.6 EFA79785.1 - 3.3e-13 49.4 14.8 3.1e-07 30.3 5.4 3.0 2 0 0 2 2 2 2 RING-type zinc-finger zf-NOSIP PF15906.5 EFA79785.1 - 4.2e-12 46.0 2.6 9.3e-12 44.9 2.6 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 EFA79785.1 - 1.8e-09 37.4 6.2 1.8e-09 37.4 6.2 2.8 1 1 2 3 3 2 2 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EFA79785.1 - 6e-09 35.9 19.6 2e-05 24.6 7.1 3.0 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFA79785.1 - 2.3e-07 30.5 20.3 0.00013 21.7 6.2 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA79785.1 - 4.2e-06 26.5 22.3 0.00022 21.0 8.9 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA79785.1 - 4.5e-06 26.4 25.9 0.00064 19.5 8.9 3.1 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA79785.1 - 5.9e-06 26.5 25.3 0.00024 21.3 10.3 3.1 3 0 0 3 3 3 2 Ring finger domain Peptidase_C1_2 PF03051.15 EFA79785.1 - 7e-05 21.8 0.1 0.0018 17.1 0.1 2.2 2 0 0 2 2 2 1 Peptidase C1-like family zf-RING_5 PF14634.6 EFA79785.1 - 8.4e-05 22.5 25.1 0.00049 20.0 11.7 3.2 2 1 1 3 3 3 2 zinc-RING finger domain FYVE PF01363.21 EFA79785.1 - 0.00055 20.0 11.0 0.00055 20.0 11.0 3.5 2 2 0 2 2 2 1 FYVE zinc finger Prok-RING_4 PF14447.6 EFA79785.1 - 0.01 15.7 3.0 0.01 15.7 3.0 3.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EFA79785.1 - 0.039 13.7 1.2 0.039 13.7 1.2 3.2 2 2 1 3 3 3 0 RING-like zinc finger Sel1 PF08238.12 EFA79786.1 - 3.7e-19 68.7 2.5 9.6e-06 26.1 0.1 5.6 5 0 0 5 5 5 4 Sel1 repeat zf-MYND PF01753.18 EFA79786.1 - 2.1e-05 24.5 11.8 5.1e-05 23.3 11.8 1.7 1 0 0 1 1 1 1 MYND finger TPR_16 PF13432.6 EFA79786.1 - 0.011 16.4 0.2 0.39 11.4 0.0 3.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA79786.1 - 0.087 12.7 4.9 69 3.5 1.7 5.8 4 1 0 4 4 4 0 Tetratricopeptide repeat Rsc14 PF08586.10 EFA79786.1 - 0.78 10.6 6.1 0.8 10.5 0.7 3.0 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit TPR_8 PF13181.6 EFA79786.1 - 1.1 9.7 0.0 1.1 9.7 0.0 5.7 6 1 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.12 EFA79788.1 - 1.3e-20 73.4 17.8 6.6e-05 23.5 0.1 8.4 7 1 1 8 8 8 5 Sel1 repeat zf-MYND PF01753.18 EFA79788.1 - 5.9e-06 26.3 7.5 1.2e-05 25.3 7.5 1.5 1 0 0 1 1 1 1 MYND finger TPR_17 PF13431.6 EFA79788.1 - 0.00029 21.0 0.1 0.3 11.6 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA79788.1 - 0.023 14.9 9.0 15 6.1 0.0 6.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA79788.1 - 0.28 11.4 13.5 23 5.4 0.2 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Rhodanese_C PF12368.8 EFA79788.1 - 0.29 11.5 3.4 0.81 10.1 3.4 1.7 1 0 0 1 1 1 0 Rhodanase C-terminal TPR_12 PF13424.6 EFA79788.1 - 0.52 10.6 5.0 30 5.0 0.1 5.4 6 2 1 7 7 7 0 Tetratricopeptide repeat Sel1 PF08238.12 EFA79790.1 - 2.5e-16 59.8 19.4 7.6e-05 23.3 0.4 6.8 7 0 0 7 7 7 4 Sel1 repeat zf-MYND PF01753.18 EFA79790.1 - 4.4e-08 33.1 8.7 1e-07 31.9 8.7 1.7 1 0 0 1 1 1 1 MYND finger TPR_1 PF00515.28 EFA79790.1 - 0.0074 16.1 8.7 52 3.9 0.4 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA79790.1 - 0.024 14.8 10.1 4.3 7.8 0.0 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA79790.1 - 0.09 13.5 4.2 45 5.0 0.0 5.9 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA79790.1 - 0.12 12.8 0.3 9.3 6.9 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA79790.1 - 0.73 10.1 15.2 20 5.6 0.0 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat zf-Mss51 PF13824.6 EFA79790.1 - 0.89 9.7 5.1 2 8.6 5.1 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Rsc14 PF08586.10 EFA79790.1 - 1.2 9.9 4.4 0.84 10.5 0.8 2.5 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit C1_2 PF03107.16 EFA79790.1 - 2.8 8.3 6.5 7.4 7.0 6.5 1.7 1 0 0 1 1 1 0 C1 domain DDE_Tnp_1_7 PF13843.6 EFA79791.1 - 1.9e-07 30.7 0.3 4.1e-07 29.6 0.3 1.5 1 1 0 1 1 1 1 Transposase IS4 Ank_2 PF12796.7 EFA79792.1 - 7.6e-05 23.2 0.8 0.12 12.9 0.0 2.9 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA79792.1 - 0.00047 20.4 0.1 3.2 8.6 0.0 4.1 5 0 0 5 5 5 2 Ankyrin repeat DUF3447 PF11929.8 EFA79792.1 - 0.0027 17.6 4.6 0.019 14.9 0.9 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF3447) Ank_5 PF13857.6 EFA79792.1 - 0.0037 17.5 0.7 1.6 9.1 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) RPA43_OB PF17875.1 EFA79794.1 - 0.14 12.8 0.1 0.27 11.8 0.1 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I F-box-like PF12937.7 EFA79794.1 - 0.18 11.8 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 F-box-like Tape_meas_lam_C PF09718.10 EFA79796.1 - 0.0044 17.1 2.7 0.16 12.1 0.1 3.0 2 1 0 2 2 2 2 Lambda phage tail tape-measure protein (Tape_meas_lam_C) PDZ_4 PF17816.1 EFA79796.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 PDZ domain AlbA_2 PF04326.14 EFA79799.1 - 5.4e-11 42.9 0.0 1.5e-10 41.5 0.0 1.8 1 0 0 1 1 1 1 Putative DNA-binding domain Coiled PF05710.12 EFA79800.1 - 7.1e-11 42.8 19.7 7.9e-11 42.6 19.7 1.0 1 0 0 1 1 1 1 Coiled coil Trypsin_2 PF13365.6 EFA79802.1 - 5.6e-09 37.1 0.0 1.2e-08 36.0 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA79802.1 - 0.026 14.3 0.0 1.4 8.7 0.0 2.3 2 1 0 2 2 2 0 Trypsin Ribonuclease_3 PF00636.26 EFA79803.1 - 7.5e-35 119.7 0.7 4.5e-17 62.6 0.0 4.1 3 1 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFA79803.1 - 3.6e-29 101.5 0.0 7.2e-15 55.3 0.0 2.8 2 1 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EFA79803.1 - 2.5e-10 40.9 0.1 7.7e-10 39.3 0.1 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EFA79803.1 - 0.047 13.9 0.0 0.25 11.7 0.0 2.3 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 Med2 PF11214.8 EFA79803.1 - 0.089 13.0 1.0 0.34 11.1 1.0 2.0 1 0 0 1 1 1 0 Mediator complex subunit 2 V-ATPase_H_N PF03224.14 EFA79804.1 - 2.7e-51 174.8 0.9 3.3e-51 174.5 0.9 1.0 1 0 0 1 1 1 1 V-ATPase subunit H DUF313 PF03754.13 EFA79804.1 - 0.026 14.7 0.1 0.066 13.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF313) V-ATPase_H_C PF11698.8 EFA79805.1 - 2.9e-43 146.7 1.3 3.8e-43 146.3 1.3 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EFA79805.1 - 5.4e-06 25.9 1.0 1.9e-05 24.1 0.1 2.0 2 1 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.13 EFA79805.1 - 3.9e-05 23.2 0.1 5.7e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Armadillo-like Nrap_D5 PF17406.2 EFA79805.1 - 0.027 14.2 0.2 0.04 13.7 0.2 1.3 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 HEAT_2 PF13646.6 EFA79805.1 - 0.036 14.4 0.0 0.16 12.4 0.0 2.0 2 1 0 2 2 2 0 HEAT repeats Cation_ATPase_C PF00689.21 EFA79806.1 - 4.6e-44 150.3 8.4 4.6e-44 150.3 8.4 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFA79806.1 - 1.2e-36 126.0 0.3 1.2e-36 126.0 0.3 3.1 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFA79806.1 - 1.3e-21 76.5 0.0 3e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA79806.1 - 1.2e-16 61.6 0.0 2.8e-16 60.4 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA79806.1 - 0.00085 19.1 0.3 0.078 12.7 0.2 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Colicin_im PF03857.13 EFA79806.1 - 0.043 13.8 2.0 0.13 12.2 2.0 1.7 1 0 0 1 1 1 0 Colicin immunity protein Cation_ATPase_N PF00690.26 EFA79806.1 - 0.88 9.3 6.6 0.079 12.7 0.8 2.4 2 1 0 2 2 2 0 Cation transporter/ATPase, N-terminus DUF3784 PF12650.7 EFA79806.1 - 1.1 9.4 7.8 1.2 9.4 0.3 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) DUF1202 PF06717.11 EFA79807.1 - 0.097 12.1 0.3 0.16 11.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) Ank_2 PF12796.7 EFA79808.1 - 7e-22 77.8 13.7 1.1e-06 29.1 0.5 5.2 3 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79808.1 - 1.6e-18 66.5 11.4 0.022 15.1 0.1 9.7 6 2 4 10 10 10 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79808.1 - 2.9e-17 62.8 10.6 0.0033 18.0 0.1 7.2 6 2 1 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79808.1 - 4.3e-15 54.3 14.3 0.77 10.5 0.0 10.9 7 2 4 11 11 11 5 Ankyrin repeat HIGH_NTase1_ass PF16581.5 EFA79808.1 - 0.0018 18.3 0.2 0.039 13.9 0.1 2.6 2 0 0 2 2 2 1 Cytidyltransferase-related C-terminal region Ank PF00023.30 EFA79808.1 - 0.014 15.8 9.9 39 4.9 0.1 6.9 6 2 2 8 8 8 0 Ankyrin repeat Phage_T7_Capsid PF05396.11 EFA79808.1 - 0.1 12.9 0.1 45 4.4 0.0 3.6 4 0 0 4 4 4 0 Phage T7 capsid assembly protein HSP20 PF00011.21 EFA79809.1 - 1.2e-07 31.8 0.7 2.7e-05 24.3 0.1 2.7 1 1 0 1 1 1 1 Hsp20/alpha crystallin family XRN1_D2_D3 PF18334.1 EFA79809.1 - 0.00026 21.1 3.1 0.27 11.5 0.0 2.5 2 1 0 2 2 2 2 Exoribonuclease Xrn1 D2/D3 domain Ank_2 PF12796.7 EFA79811.1 - 5.3e-24 84.6 21.4 8.8e-09 35.8 2.5 6.9 2 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79811.1 - 5.9e-23 80.9 12.3 0.00085 19.8 0.3 7.5 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79811.1 - 1.3e-18 66.8 16.7 0.22 11.9 0.1 10.5 7 4 5 12 12 12 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79811.1 - 2.6e-16 58.1 10.9 0.13 12.9 0.0 11.6 12 0 0 12 12 12 3 Ankyrin repeat Ank PF00023.30 EFA79811.1 - 0.00031 21.1 10.7 1.8 9.2 0.0 7.0 7 2 0 8 8 8 2 Ankyrin repeat DUF1843 PF08898.10 EFA79811.1 - 0.15 12.6 1.3 98 3.6 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF1843) DUF3447 PF11929.8 EFA79811.1 - 0.45 10.5 28.3 0.031 14.2 1.2 6.5 4 1 2 6 6 6 0 Domain of unknown function (DUF3447) DUF3130 PF11328.8 EFA79813.1 - 0.014 15.6 0.4 0.031 14.5 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3130 Ras PF00071.22 EFA79814.1 - 4.1e-29 101.3 0.1 4.1e-29 101.3 0.1 2.6 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFA79814.1 - 1.4e-08 34.9 0.1 1.1e-07 32.0 0.1 2.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase zf-B_box PF00643.24 EFA79814.1 - 0.0048 17.0 13.9 0.0082 16.3 13.9 1.4 1 0 0 1 1 1 1 B-box zinc finger RsgA_GTPase PF03193.16 EFA79814.1 - 0.0091 15.9 3.9 1.9 8.3 0.0 3.5 2 2 1 3 3 3 2 RsgA GTPase DUF2203 PF09969.9 EFA79814.1 - 0.016 16.0 5.3 0.59 10.9 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) AATF-Che1 PF13339.6 EFA79814.1 - 3 8.5 20.0 1.2 9.8 8.1 2.5 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor AIF_C PF14721.6 EFA79814.1 - 6.4 7.2 10.2 1.5 9.2 1.4 2.6 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term POX PF07526.11 EFA79814.1 - 7.5 7.1 8.4 12 6.5 1.7 2.4 2 0 0 2 2 2 0 Associated with HOX zf-UBP PF02148.19 EFA79814.1 - 9.7 6.6 13.9 0.82 10.1 7.5 2.5 3 0 0 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein SAP PF02037.27 EFA79817.1 - 0.00039 20.1 0.1 0.0011 18.7 0.1 1.7 1 0 0 1 1 1 1 SAP domain Rho_N PF07498.12 EFA79817.1 - 0.012 15.5 1.3 0.034 14.1 1.3 1.8 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain LRR_4 PF12799.7 EFA79817.1 - 0.072 13.5 6.9 2.6 8.6 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) Kelch_6 PF13964.6 EFA79819.1 - 1.9e-10 40.6 2.4 8.8e-06 25.8 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EFA79819.1 - 0.079 13.0 0.2 3.5 7.7 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain PFK PF00365.20 EFA79820.1 - 7.7e-189 625.9 3.0 1.1e-105 353.0 0.2 2.3 2 0 0 2 2 2 2 Phosphofructokinase HIT PF01230.23 EFA79820.1 - 3.9e-24 85.2 0.0 1e-23 83.9 0.0 1.7 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFA79820.1 - 5.8e-07 30.0 0.0 1.3e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding TPR_MLP1_2 PF07926.12 EFA79822.1 - 0.00032 20.8 18.1 0.002 18.2 6.9 2.1 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 EFA79822.1 - 0.0041 15.8 10.6 0.0051 15.5 10.6 1.0 1 0 0 1 1 1 1 AAA domain DUF2935 PF11155.8 EFA79822.1 - 0.0044 17.3 2.4 0.011 16.0 1.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF2935) DUF5082 PF16888.5 EFA79822.1 - 0.0047 17.2 13.1 0.19 12.0 7.5 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5082) YabA PF06156.13 EFA79822.1 - 0.0048 17.5 14.6 0.3 11.7 6.6 2.7 1 1 1 2 2 2 2 Initiation control protein YabA CENP-F_leu_zip PF10473.9 EFA79822.1 - 0.006 16.6 20.6 0.12 12.4 3.4 2.1 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 EFA79822.1 - 0.0075 15.6 16.6 0.0068 15.8 15.5 1.4 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EFA79822.1 - 0.0083 16.2 16.5 0.013 15.6 16.5 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus KASH_CCD PF14662.6 EFA79822.1 - 0.0098 15.7 15.7 0.031 14.1 9.2 2.1 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH FAM76 PF16046.5 EFA79822.1 - 0.015 14.7 12.2 0.022 14.2 12.2 1.2 1 0 0 1 1 1 0 FAM76 protein FAM184 PF15665.5 EFA79822.1 - 0.022 14.5 15.8 0.073 12.8 15.4 1.7 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF641 PF04859.12 EFA79822.1 - 0.023 15.0 4.6 0.023 15.0 4.6 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Lebercilin PF15619.6 EFA79822.1 - 0.027 14.2 18.0 0.04 13.6 18.0 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Fez1 PF06818.15 EFA79822.1 - 0.033 14.6 14.1 0.041 14.3 14.1 1.1 1 0 0 1 1 1 0 Fez1 TLE_N PF03920.15 EFA79822.1 - 0.034 14.2 7.4 1.7 8.7 2.9 2.8 1 1 1 2 2 2 0 Groucho/TLE N-terminal Q-rich domain ATG16 PF08614.11 EFA79822.1 - 0.035 14.3 18.3 0.65 10.2 4.3 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 EFA79822.1 - 0.04 13.7 18.7 0.15 11.8 3.2 3.2 1 1 2 3 3 3 0 Septum formation initiator Mod_r PF07200.13 EFA79822.1 - 0.055 13.6 18.8 0.041 14.0 4.6 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.11 EFA79822.1 - 0.073 13.3 6.9 2.3 8.5 2.3 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) MtrB PF05440.12 EFA79822.1 - 0.099 13.1 0.4 5.6 7.5 0.0 2.5 1 1 2 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B RmuC PF02646.16 EFA79822.1 - 0.1 11.7 18.7 0.44 9.6 7.0 2.1 1 1 1 2 2 2 0 RmuC family Exonuc_VII_L PF02601.15 EFA79822.1 - 0.12 11.9 7.9 0.17 11.4 7.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3450 PF11932.8 EFA79822.1 - 0.14 11.4 16.6 0.62 9.3 6.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 EFA79822.1 - 0.15 10.9 18.9 0.42 9.4 18.9 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EFA79822.1 - 0.2 11.0 14.0 0.67 9.3 14.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) IFT20 PF14931.6 EFA79822.1 - 0.21 11.7 14.2 0.034 14.3 4.7 2.3 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 DUF1664 PF07889.12 EFA79822.1 - 0.27 11.3 9.5 0.23 11.5 6.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Ax_dynein_light PF10211.9 EFA79822.1 - 0.48 10.3 16.7 1.4 8.8 5.6 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain Atg14 PF10186.9 EFA79822.1 - 1 8.4 19.1 37 3.3 19.1 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 EFA79822.1 - 1.5 9.4 12.5 9.6 6.8 4.7 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EFA79822.1 - 2.4 8.4 15.0 2.7 8.2 13.5 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.6 EFA79822.1 - 2.9 8.3 18.9 3.1 8.2 6.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 EFA79822.1 - 3 8.4 19.2 0.95 10.0 5.3 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region LMBR1 PF04791.16 EFA79822.1 - 3.3 6.5 8.1 3.4 6.4 7.3 1.4 1 1 1 2 2 2 0 LMBR1-like membrane protein DUF4795 PF16043.5 EFA79822.1 - 3.7 7.1 17.0 54 3.3 15.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4446 PF14584.6 EFA79822.1 - 4.1 7.4 11.0 3.6 7.6 2.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) DUF16 PF01519.16 EFA79822.1 - 6.5 7.3 16.2 2.7 8.5 1.7 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 HALZ PF02183.18 EFA79822.1 - 9.2 6.6 12.7 0.27 11.5 1.3 3.3 2 1 0 2 2 2 0 Homeobox associated leucine zipper SlyX PF04102.12 EFA79823.1 - 0.0018 18.9 4.0 0.0018 18.9 4.0 6.3 3 2 3 6 6 6 2 SlyX Csm1_N PF18504.1 EFA79823.1 - 0.025 14.9 9.9 0.025 14.9 9.9 7.3 2 2 5 7 7 7 0 Csm1 N-terminal domain DUF2188 PF09954.9 EFA79823.1 - 0.2 11.8 3.0 2.4 8.4 0.1 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) YqjK PF13997.6 EFA79823.1 - 0.54 10.5 4.1 84 3.5 0.0 3.8 1 1 2 3 3 3 0 YqjK-like protein Filament PF00038.21 EFA79823.1 - 6.9 6.2 78.6 11 5.4 50.7 3.5 1 1 1 2 2 2 0 Intermediate filament protein LPP PF04728.13 EFA79823.1 - 7.6 7.0 19.4 7.2 7.1 0.1 4.6 4 1 0 4 4 4 0 Lipoprotein leucine-zipper Myb_DNA-binding PF00249.31 EFA79824.1 - 9.5e-11 41.7 0.1 1.7e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA79824.1 - 0.012 15.9 0.4 0.046 14.0 0.4 2.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain Adaptin_binding PF10199.9 EFA79825.1 - 0.079 13.6 0.2 0.079 13.6 0.2 1.6 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Ank_2 PF12796.7 EFA79826.1 - 1.9e-20 73.2 6.3 3.8e-09 37.0 0.1 6.2 4 2 1 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA79826.1 - 8e-16 57.9 6.5 0.00011 22.4 0.0 9.0 6 3 4 10 10 10 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA79826.1 - 3e-14 53.2 8.7 6.7e-05 23.4 0.0 8.2 8 1 1 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79826.1 - 3.9e-09 36.0 0.7 66 4.6 0.0 9.0 9 0 0 9 9 9 0 Ankyrin repeat Ank PF00023.30 EFA79826.1 - 0.024 15.1 1.1 2.3e+02 2.5 0.0 6.0 5 2 0 5 5 5 0 Ankyrin repeat Carot_N PF09150.10 EFA79826.1 - 0.13 12.1 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal Ank_2 PF12796.7 EFA79829.1 - 1.9e-21 76.4 14.7 1.8e-07 31.7 0.8 6.4 3 2 4 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79829.1 - 2.4e-19 69.4 11.8 1.1e-05 25.9 0.1 8.4 5 3 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79829.1 - 7.5e-15 54.8 11.0 0.03 14.6 0.0 9.9 4 1 7 11 11 11 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79829.1 - 1.6e-14 52.6 7.3 0.79 10.5 0.0 11.1 11 0 0 11 11 11 2 Ankyrin repeat Ank PF00023.30 EFA79829.1 - 7.2e-05 23.1 5.4 11 6.7 0.0 7.6 7 2 1 8 8 8 1 Ankyrin repeat DUF5049 PF16468.5 EFA79829.1 - 0.023 14.6 1.9 36 4.4 0.0 5.5 7 0 0 7 7 7 0 Domain of unknown function (DUF5049) Methyltransf_21 PF05050.12 EFA79829.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase FkbM domain UL41A PF17591.2 EFA79831.1 - 0.078 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL41A Kelch_6 PF13964.6 EFA79832.1 - 4.3e-08 33.2 0.9 2.3e-06 27.7 0.0 3.5 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 EFA79832.1 - 0.015 14.8 0.0 0.038 13.6 0.0 1.7 1 0 0 1 1 1 0 Kelch motif DUF1048 PF06304.11 EFA79832.1 - 0.057 13.9 0.2 1.2 9.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1048) UCH PF00443.29 EFA79836.1 - 1.1e-41 143.0 38.3 1.1e-40 139.8 38.3 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA79836.1 - 0.00015 21.5 0.1 0.00015 21.5 0.1 4.5 3 2 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase DUF4428 PF14471.6 EFA79836.1 - 0.026 14.5 0.4 1.6 8.7 0.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) zf-RING_5 PF14634.6 EFA79836.1 - 1.2 9.1 3.8 4.7 7.3 0.3 2.5 2 0 0 2 2 2 0 zinc-RING finger domain Zn_Tnp_IS1595 PF12760.7 EFA79836.1 - 2.3 8.3 4.5 4.2 7.4 0.1 2.9 4 0 0 4 4 4 0 Transposase zinc-ribbon domain FYVE PF01363.21 EFA79837.1 - 1.3e-19 70.1 7.6 2.3e-19 69.3 7.6 1.4 1 0 0 1 1 1 1 FYVE zinc finger Pkinase PF00069.25 EFA79837.1 - 0.00015 21.2 0.0 0.0011 18.4 0.1 2.1 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79837.1 - 0.0025 17.1 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase WH2 PF02205.20 EFA79837.1 - 0.026 14.3 0.0 0.084 12.7 0.0 1.9 1 0 0 1 1 1 0 WH2 motif FYVE_2 PF02318.16 EFA79837.1 - 0.035 14.3 4.2 0.069 13.4 4.2 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Zn_ribbon_SprT PF17283.2 EFA79837.1 - 4.2 7.4 14.0 0.38 10.7 6.2 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DZR PF12773.7 EFA79837.1 - 8.6 6.5 10.1 1.3e+02 2.7 10.1 2.3 1 1 0 1 1 1 0 Double zinc ribbon C2 PF00168.30 EFA79838.1 - 1.2e-06 28.7 0.1 5.2e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 C2 domain PI3K_C2 PF00792.24 EFA79838.1 - 0.018 14.9 0.4 0.042 13.7 0.4 1.6 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 Pkinase PF00069.25 EFA79839.1 - 5.4e-20 71.9 0.0 7.9e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79839.1 - 8.1e-06 25.3 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EFA79839.1 - 0.00014 22.5 0.0 0.00057 20.5 0.0 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain CYYR1 PF10873.8 EFA79839.1 - 7.5 7.0 7.1 2.2 8.7 3.8 1.8 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Cpn60_TCP1 PF00118.24 EFA79840.1 - 3.3e-156 520.7 4.2 4.1e-156 520.5 4.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-C3HC4_3 PF13920.6 EFA79841.1 - 4.8e-10 39.1 8.6 1e-09 38.1 8.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA79841.1 - 0.00015 22.0 10.4 0.00046 20.5 10.4 1.9 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFA79841.1 - 0.0023 17.8 9.1 0.0047 16.8 9.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFA79841.1 - 0.0046 16.8 10.8 0.012 15.5 10.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA79841.1 - 0.01 15.7 10.6 0.033 14.0 10.6 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA79841.1 - 0.017 15.1 11.6 0.045 13.7 11.6 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Soc PF16855.5 EFA79841.1 - 0.1 13.1 0.2 1.6 9.3 0.0 2.8 3 0 0 3 3 3 0 Small outer capsid protein zf-RING_UBOX PF13445.6 EFA79841.1 - 3.3 7.8 10.1 8.7 6.5 10.1 1.8 1 0 0 1 1 1 0 RING-type zinc-finger LIN52 PF10044.9 EFA79842.1 - 7.7e-05 23.3 0.3 0.00011 22.9 0.3 1.3 1 1 0 1 1 1 1 Retinal tissue protein ToxS PF17323.2 EFA79844.1 - 0.043 13.5 1.2 0.24 11.1 0.1 2.4 2 1 1 3 3 3 0 Trans-membrane regulatory protein ToxS DUF5390 PF17365.2 EFA79848.1 - 0.016 15.5 0.4 0.029 14.6 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5390) Ribosomal_L2_C PF03947.18 EFA79851.1 - 6.9e-46 155.5 2.9 1.3e-45 154.7 2.9 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFA79851.1 - 1.2e-21 76.4 0.0 4.8e-21 74.5 0.0 2.1 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Cofilin_ADF PF00241.20 EFA79852.1 - 9.1e-36 122.3 0.8 2.6e-20 72.4 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein BolA PF01722.18 EFA79853.1 - 4.2e-12 46.2 0.0 1.2e-11 44.7 0.0 1.7 1 1 0 1 1 1 1 BolA-like protein dUTPase_2 PF08761.11 EFA79853.1 - 0.074 13.2 0.2 0.09 12.9 0.2 1.2 1 0 0 1 1 1 0 dUTPase COMM_domain PF07258.14 EFA79854.1 - 1.1e-16 60.6 0.3 4.4e-16 58.8 0.1 2.1 2 0 0 2 2 2 1 COMM domain RNase_HII PF01351.18 EFA79854.1 - 0.22 11.3 3.0 0.24 11.2 1.6 1.7 1 1 1 2 2 2 0 Ribonuclease HII Polyketide_cyc PF03364.20 EFA79855.1 - 2e-21 76.6 0.0 2.8e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EFA79855.1 - 5.3e-05 23.5 0.0 7.9e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport zf_Hakai PF18408.1 EFA79855.1 - 0.28 10.9 1.6 1.9 8.3 0.1 2.3 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain JTB PF05439.12 EFA79856.1 - 1.2e-09 38.2 4.7 1.7e-09 37.7 4.7 1.2 1 0 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) TMEM223 PF14640.6 EFA79856.1 - 0.2 11.8 2.6 0.54 10.4 0.5 2.4 1 1 1 2 2 2 0 Transmembrane protein 223 Orf78 PF06024.12 EFA79856.1 - 1.2 9.5 8.0 64 3.9 8.0 2.2 1 1 0 1 1 1 0 Orf78 (ac78) Atx10homo_assoc PF09759.9 EFA79857.1 - 0.00031 20.7 8.0 0.001 19.0 0.2 3.9 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain F-box PF00646.33 EFA79857.1 - 0.0011 18.8 3.1 0.0036 17.2 3.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA79857.1 - 0.0016 18.3 1.8 0.0038 17.1 1.8 1.6 1 0 0 1 1 1 1 F-box-like DUF3361 PF11841.8 EFA79857.1 - 0.59 10.1 12.7 0.2 11.6 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) MID_MedPIWI PF18296.1 EFA79858.1 - 0.0048 16.7 8.7 0.0092 15.8 8.7 1.4 1 0 0 1 1 1 1 MID domain of medPIWI AAA_11 PF13086.6 EFA79858.1 - 0.03 14.1 12.1 0.84 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFA79858.1 - 0.041 13.8 0.4 0.18 11.7 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EFA79858.1 - 0.046 13.7 1.5 0.077 13.0 0.1 2.3 2 1 0 2 2 1 0 AAA domain T2SSE PF00437.20 EFA79858.1 - 0.082 11.9 0.0 0.17 10.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CCDC53 PF10152.9 EFA79858.1 - 0.12 12.8 8.5 0.23 11.9 8.5 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Neur_chan_memb PF02932.16 EFA79858.1 - 0.14 12.2 3.3 0.23 11.5 3.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3492 PF11997.8 EFA79858.1 - 0.19 11.5 5.2 0.33 10.6 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Ctr PF04145.15 EFA79858.1 - 0.25 12.0 1.7 0.47 11.1 1.7 1.5 1 0 0 1 1 1 0 Ctr copper transporter family CNDH2_M PF16869.5 EFA79858.1 - 0.33 11.7 7.0 0.74 10.5 7.0 1.5 1 0 0 1 1 1 0 PF16858 CobT PF06213.12 EFA79858.1 - 0.36 10.2 13.3 0.55 9.6 13.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RMP PF14996.6 EFA79858.1 - 0.53 10.5 12.8 49 4.1 0.0 2.5 2 0 0 2 2 2 0 Retinal Maintenance Pex14_N PF04695.13 EFA79858.1 - 0.97 10.1 16.5 1.6 9.3 16.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AFT PF08731.11 EFA79858.1 - 2.1 8.8 9.7 2.6 8.5 0.1 2.5 2 0 0 2 2 2 0 Transcription factor AFT Presenilin PF01080.17 EFA79858.1 - 2.6 6.7 13.7 3.9 6.1 13.7 1.2 1 0 0 1 1 1 0 Presenilin ANAPC_CDC26 PF10471.9 EFA79858.1 - 3.3 8.6 24.8 6.6 7.7 24.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Kei1 PF08552.11 EFA79858.1 - 4.4 7.1 7.3 8 6.3 7.3 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 RP-C_C PF11800.8 EFA79858.1 - 6.8 6.7 10.4 6.9 6.7 9.2 1.5 2 0 0 2 2 2 0 Replication protein C C-terminal region Spt20 PF12090.8 EFA79858.1 - 7.5 6.1 28.8 14 5.2 28.2 1.7 2 0 0 2 2 2 0 Spt20 family MAP70 PF07058.11 EFA79858.1 - 7.5 5.2 9.8 4.4 5.9 7.1 1.7 2 0 0 2 2 2 0 Microtubule-associated protein 70 CLN3 PF02487.17 EFA79858.1 - 9.5 5.1 9.1 18 4.2 9.1 1.4 1 0 0 1 1 1 0 CLN3 protein DnaJ PF00226.31 EFA79862.1 - 4.5e-13 49.1 0.3 1.3e-12 47.6 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain GYF_2 PF14237.6 EFA79862.1 - 2.2e-12 46.6 0.0 8.1e-12 44.8 0.0 2.0 2 0 0 2 2 2 1 GYF domain 2 DUF3361 PF11841.8 EFA79862.1 - 0.34 10.8 3.4 3.7 7.5 0.7 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) Methyltransf_16 PF10294.9 EFA79863.1 - 2e-29 102.5 0.1 2.9e-28 98.7 0.1 2.1 2 0 0 2 2 2 1 Lysine methyltransferase MTS PF05175.14 EFA79863.1 - 0.026 14.1 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FAM176 PF14851.6 EFA79863.1 - 0.11 12.1 2.2 0.21 11.3 2.2 1.5 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EFA79863.1 - 0.4 8.9 6.2 0.51 8.6 6.2 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 EFA79863.1 - 2.2 8.5 16.2 4 7.6 16.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4820 PF16091.5 EFA79863.1 - 4.4 6.6 7.0 6.6 6.0 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SLBP_RNA_bind PF15247.6 EFA79864.1 - 2.1e-28 98.3 2.8 2.1e-28 98.3 2.8 2.3 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain SUIM_assoc PF16619.5 EFA79864.1 - 6.2 7.0 14.9 3.6 7.7 8.3 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ndr PF03096.14 EFA79865.1 - 4.8e-66 222.3 0.1 5.8e-66 222.1 0.1 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 EFA79865.1 - 0.00022 20.9 0.0 0.0026 17.5 0.0 2.0 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA79865.1 - 0.00036 19.9 0.0 0.00059 19.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 zf-B_box PF00643.24 EFA79866.1 - 0.01 16.0 11.0 0.01 16.0 11.0 2.0 2 0 0 2 2 2 0 B-box zinc finger DUF3601 PF12208.8 EFA79866.1 - 0.11 12.6 1.0 3.1 8.0 0.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3601) Kelch_6 PF13964.6 EFA79867.1 - 8e-07 29.1 8.7 0.00042 20.5 0.1 5.5 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA79867.1 - 0.0044 17.1 4.1 0.014 15.5 4.1 1.8 1 0 0 1 1 1 1 B-box zinc finger Nup54 PF13874.6 EFA79867.1 - 0.35 11.0 5.0 0.066 13.3 1.2 1.7 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Zn_Tnp_IS91 PF14319.6 EFA79867.1 - 1.2 9.2 6.0 1.7 8.7 2.4 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain DUF4637 PF15470.6 EFA79867.1 - 2.5 7.8 7.1 0.23 11.2 2.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) RIO1 PF01163.22 EFA79869.1 - 8.8e-76 253.7 0.1 2.1e-75 252.5 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Ras PF00071.22 EFA79869.1 - 1.4e-38 132.1 0.4 1.2e-37 129.0 0.4 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA79869.1 - 2.2e-12 47.3 0.0 9.6e-12 45.2 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Pkinase_fungal PF17667.1 EFA79869.1 - 0.00041 19.3 3.9 0.0005 19.0 2.6 2.0 1 1 0 1 1 1 1 Fungal protein kinase MMR_HSR1 PF01926.23 EFA79869.1 - 0.0093 16.0 0.1 0.036 14.2 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA79869.1 - 0.015 14.8 0.2 0.05 13.1 0.1 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Arf PF00025.21 EFA79869.1 - 0.017 14.6 0.1 0.24 10.8 0.1 2.3 1 1 0 1 1 1 0 ADP-ribosylation factor family NOA36 PF06524.12 EFA79869.1 - 0.86 8.9 31.3 0.35 10.2 13.2 2.5 2 0 0 2 2 2 0 NOA36 protein TFIIA PF03153.13 EFA79869.1 - 2.5 8.0 28.3 2.8 7.8 10.4 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit GATA PF00320.27 EFA79870.1 - 2.2e-06 27.2 4.4 2.2e-06 27.2 4.4 2.0 1 1 0 1 1 1 1 GATA zinc finger PHD PF00628.29 EFA79870.1 - 0.0042 16.9 10.5 0.0042 16.9 10.5 3.1 3 1 0 3 3 3 1 PHD-finger Zn-C2H2_12 PF18112.1 EFA79870.1 - 0.053 14.0 1.9 0.075 13.5 0.2 2.3 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-HIT PF04438.16 EFA79870.1 - 3.6 7.5 10.4 7.6 6.5 1.5 3.0 2 0 0 2 2 2 0 HIT zinc finger zf-RING_5 PF14634.6 EFA79870.1 - 4.2 7.4 12.6 0.24 11.4 1.4 3.4 3 0 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFA79870.1 - 5.9 6.8 8.4 1.6 8.6 2.7 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Lar_restr_allev PF14354.6 EFA79870.1 - 9.7 6.7 14.1 3.6 8.0 4.5 3.4 2 1 1 3 3 3 0 Restriction alleviation protein Lar Oxysterol_BP PF01237.18 EFA79871.1 - 1.2e-82 277.7 5.3 1.4e-73 247.9 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein MutL_C PF08676.11 EFA79872.1 - 4.3e-27 94.7 0.0 8.2e-27 93.8 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EFA79872.1 - 2.3e-23 82.1 0.0 7.5e-23 80.5 0.0 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFA79872.1 - 3.4e-14 52.8 0.1 1.3e-13 50.9 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Med13_C PF06333.12 EFA79872.1 - 0.61 9.3 10.7 1.4 8.2 10.7 1.6 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain TFIID-31kDa PF02291.15 EFA79873.1 - 3.1e-41 140.3 0.0 6.8e-41 139.2 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFA79873.1 - 8e-05 22.6 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated CENP-S PF15630.6 EFA79873.1 - 0.00023 21.5 0.0 0.00096 19.5 0.0 2.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EFA79873.1 - 0.011 15.9 2.5 0.014 15.5 0.1 2.4 3 0 0 3 3 3 0 Centromere kinetochore component CENP-T histone fold TFIID_30kDa PF03540.13 EFA79873.1 - 0.03 14.3 0.1 0.066 13.2 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit Macoilin PF09726.9 EFA79873.1 - 0.43 9.1 29.0 0.66 8.5 29.0 1.3 1 0 0 1 1 1 0 Macoilin family Utp14 PF04615.13 EFA79873.1 - 3.2 6.2 40.9 4.2 5.8 40.9 1.1 1 0 0 1 1 1 0 Utp14 protein DUF4776 PF16003.5 EFA79873.1 - 6.6 5.6 31.1 9.4 5.1 31.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SAM_3 PF18016.1 EFA79874.1 - 0.0067 16.2 0.9 0.017 14.9 0.1 2.1 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFA79874.1 - 0.075 13.5 0.2 0.25 11.8 0.0 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) 2OG-FeII_Oxy_3 PF13640.6 EFA79875.1 - 2.5e-11 44.3 0.0 3.9e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 EFA79875.1 - 1.1e-06 29.0 0.0 4.6e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Pox_C4_C10 PF03336.13 EFA79875.1 - 0.0027 16.9 0.0 0.0029 16.8 0.0 1.1 1 0 0 1 1 1 1 Poxvirus C4/C10 protein DNA_ligase_OB_2 PF14743.6 EFA79875.1 - 0.12 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 DNA ligase OB-like domain Cytochrom_B561 PF03188.16 EFA79876.1 - 8.2e-12 45.4 7.9 1.8e-11 44.3 7.9 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.17 EFA79876.1 - 9.2e-11 42.0 0.2 1.3e-10 41.6 0.2 1.2 1 0 0 1 1 1 1 DOMON domain DUF4079 PF13301.6 EFA79876.1 - 0.0028 17.8 0.7 0.0028 17.8 0.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4079) DOMON PF03351.17 EFA79877.1 - 1.8e-17 63.7 0.4 2.7e-17 63.1 0.4 1.3 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 EFA79877.1 - 4e-12 46.5 13.8 8.1e-12 45.5 13.8 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EFA79877.1 - 0.0039 17.4 7.6 0.0072 16.5 4.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4079) DHHC PF01529.20 EFA79878.1 - 0.07 13.2 0.4 0.34 11.0 0.0 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase ChlamPMP_M PF07548.11 EFA79878.1 - 0.36 10.8 6.6 2.7 7.9 6.4 2.7 1 1 0 1 1 1 0 Chlamydia polymorphic membrane protein middle domain AIDA PF16168.5 EFA79878.1 - 0.79 9.9 6.3 0.55 10.3 0.3 3.1 3 0 0 3 3 3 0 Adhesin of bacterial autotransporter system, probable stalk Glyco_hydro_18 PF00704.28 EFA79879.1 - 7.8e-06 25.8 0.2 1.9e-05 24.6 0.0 1.6 1 1 1 2 2 2 1 Glycosyl hydrolases family 18 Methyltransf_32 PF13679.6 EFA79879.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain La PF05383.17 EFA79880.1 - 9.5e-11 41.6 0.1 2.7e-10 40.1 0.1 1.7 1 0 0 1 1 1 1 La domain Ank_2 PF12796.7 EFA79881.1 - 4.1e-15 56.1 2.9 1.6e-05 25.4 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79881.1 - 1.2e-09 38.5 5.4 0.02 15.5 0.0 5.9 4 2 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79881.1 - 9.4e-09 34.8 1.0 0.14 12.8 0.0 6.1 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EFA79881.1 - 8.1e-05 22.8 2.6 1.6 9.2 0.2 4.7 4 2 2 6 6 6 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA79881.1 - 0.0002 21.6 2.1 5.1 7.7 0.3 5.2 5 1 0 5 5 5 2 Ankyrin repeat RNB PF00773.19 EFA79882.1 - 8.2e-18 64.8 0.9 8.2e-18 64.8 0.9 3.5 4 1 0 4 4 4 1 RNB domain Kelch_6 PF13964.6 EFA79882.1 - 1.4e-06 28.4 6.7 0.00023 21.3 0.1 5.3 4 1 1 5 5 5 1 Kelch motif zf-B_box PF00643.24 EFA79882.1 - 0.0058 16.8 6.4 0.0058 16.8 6.4 2.1 2 0 0 2 2 2 1 B-box zinc finger zf-B_box PF00643.24 EFA79883.1 - 0.00052 20.1 5.6 0.00052 20.1 5.6 2.2 2 0 0 2 2 2 1 B-box zinc finger RNA_pol_Rpc4 PF05132.14 EFA79884.1 - 7.1e-20 71.9 0.0 7.1e-20 71.9 0.0 3.5 3 1 1 4 4 4 1 RNA polymerase III RPC4 Hamartin PF04388.12 EFA79884.1 - 6 5.4 23.9 8.8 4.9 23.9 1.2 1 0 0 1 1 1 0 Hamartin protein CoaE PF01121.20 EFA79885.1 - 4.7e-45 153.5 0.1 5.6e-45 153.2 0.1 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_28 PF13521.6 EFA79885.1 - 0.00082 19.7 0.1 0.0023 18.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFA79885.1 - 0.0026 18.3 2.4 0.013 16.0 2.4 2.2 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 EFA79885.1 - 0.0059 16.8 0.5 0.0095 16.1 0.5 1.3 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_33 PF13671.6 EFA79885.1 - 0.012 15.7 0.1 0.054 13.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain Etmic-2 PF06670.11 EFA79885.1 - 0.065 12.2 0.1 0.089 11.7 0.1 1.1 1 0 0 1 1 1 0 Microneme protein Etmic-2 ABC_tran PF00005.27 EFA79885.1 - 0.17 12.4 0.4 0.34 11.4 0.4 1.7 1 1 0 1 1 1 0 ABC transporter SRF-TF PF00319.18 EFA79888.1 - 2e-19 68.8 0.2 3.3e-19 68.1 0.2 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) MRNIP PF15749.5 EFA79889.1 - 0.028 15.1 3.9 0.045 14.5 3.9 1.3 1 0 0 1 1 1 0 MRN-interacting protein DUF4834 PF16118.5 EFA79889.1 - 3.4 8.7 5.6 8.1 7.5 5.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Mrpl_C PF18502.1 EFA79890.1 - 0.074 13.3 2.1 0.077 13.3 2.1 1.1 1 0 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain ABC_tran PF00005.27 EFA79891.1 - 1.1e-43 149.1 0.0 2e-20 73.7 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EFA79891.1 - 2.3e-21 75.6 4.0 2.3e-21 75.6 4.0 3.3 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 EFA79891.1 - 4.4e-21 76.0 0.0 6.1e-05 23.0 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA79891.1 - 4.1e-09 36.2 2.0 0.065 12.7 0.1 4.8 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFA79891.1 - 9.9e-06 25.5 9.7 0.012 15.4 0.0 4.0 3 1 1 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 EFA79891.1 - 1.2e-05 24.9 0.0 0.0096 15.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA79891.1 - 4.7e-05 23.7 0.0 0.0019 18.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFA79891.1 - 9e-05 22.4 0.0 0.079 12.9 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.6 EFA79891.1 - 0.00024 21.3 0.0 0.22 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFA79891.1 - 0.00026 21.0 0.7 0.027 14.4 0.0 3.0 3 0 0 3 3 3 1 RsgA GTPase RNA_helicase PF00910.22 EFA79891.1 - 0.00043 20.6 0.0 0.097 13.1 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_23 PF13476.6 EFA79891.1 - 0.00061 20.3 14.8 0.033 14.7 0.0 4.7 4 1 1 5 5 5 2 AAA domain DUF87 PF01935.17 EFA79891.1 - 0.00082 19.5 0.7 0.23 11.5 0.0 3.5 2 1 1 3 3 3 1 Helicase HerA, central domain AAA_16 PF13191.6 EFA79891.1 - 0.00094 19.6 0.0 0.046 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EFA79891.1 - 0.0012 18.4 0.0 0.2 11.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 EFA79891.1 - 0.0016 18.8 0.0 0.038 14.4 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFA79891.1 - 0.0019 18.5 0.0 0.19 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFA79891.1 - 0.0021 18.1 0.2 4.3 7.4 0.0 3.7 5 0 0 5 5 4 1 AAA domain AAA_24 PF13479.6 EFA79891.1 - 0.0031 17.3 0.0 0.33 10.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EFA79891.1 - 0.0038 16.8 0.0 0.98 9.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EFA79891.1 - 0.0072 16.4 0.0 0.13 12.4 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EFA79891.1 - 0.009 15.7 0.0 0.077 12.7 0.0 2.5 4 0 0 4 4 3 1 AAA domain ABC_ATPase PF09818.9 EFA79891.1 - 0.019 13.8 0.4 13 4.4 0.0 3.8 4 0 0 4 4 4 0 Predicted ATPase of the ABC class AAA_5 PF07728.14 EFA79891.1 - 0.022 14.7 0.9 0.34 10.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF2813 PF11398.8 EFA79891.1 - 0.041 13.1 0.0 2.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) AAA_18 PF13238.6 EFA79891.1 - 0.064 13.8 0.0 2 9.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain Rad60-SLD PF11976.8 EFA79891.1 - 0.074 12.9 0.4 2.6 7.9 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like Dynamin_N PF00350.23 EFA79891.1 - 0.088 12.9 0.3 11 6.0 0.0 3.3 3 1 0 3 3 2 0 Dynamin family TsaE PF02367.17 EFA79891.1 - 0.11 12.5 0.0 1.1 9.2 0.0 2.5 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE adh_short PF00106.25 EFA79892.1 - 2e-48 164.5 0.0 3e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA79892.1 - 1.2e-33 116.6 0.0 2.3e-33 115.7 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA79892.1 - 2e-13 50.7 0.0 2.8e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFA79892.1 - 8.1e-05 22.6 0.1 0.00013 21.9 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFA79892.1 - 0.00013 21.2 0.0 0.00021 20.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EFA79892.1 - 0.0011 18.5 0.2 0.0037 16.8 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EFA79892.1 - 0.0014 18.0 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFA79892.1 - 0.015 14.7 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Ank_2 PF12796.7 EFA79893.1 - 0.021 15.4 0.0 1.3 9.7 0.0 2.2 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) NADHdeh_related PF10125.9 EFA79893.1 - 0.023 14.1 0.0 0.035 13.5 0.0 1.4 1 1 0 1 1 1 0 NADH dehydrogenase I, subunit N related protein Ank_3 PF13606.6 EFA79893.1 - 0.057 14.0 0.7 64 4.6 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat adh_short PF00106.25 EFA79894.1 - 3.6e-48 163.6 0.1 4.9e-48 163.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA79894.1 - 2.2e-33 115.8 0.0 2.8e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA79894.1 - 6.6e-14 52.2 0.1 9.4e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFA79894.1 - 6.3e-05 23.0 0.1 0.00011 22.2 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFA79894.1 - 0.00018 20.7 0.0 0.00029 20.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EFA79894.1 - 0.00024 20.7 0.2 0.0015 18.1 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EFA79894.1 - 0.0005 19.5 0.0 0.00073 19.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFA79894.1 - 0.027 13.9 0.3 0.055 12.9 0.1 1.6 1 1 1 2 2 2 0 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 EFA79894.1 - 0.17 11.9 0.4 0.46 10.5 0.1 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase AT_hook PF02178.19 EFA79895.1 - 0.00025 20.6 11.5 0.0068 16.2 3.5 2.5 2 0 0 2 2 2 2 AT hook motif mit_SMPDase PF14724.6 EFA79895.1 - 0.051 11.6 0.0 0.056 11.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase DENN PF02141.21 EFA79895.1 - 0.14 12.1 0.2 0.19 11.7 0.2 1.3 1 1 0 1 1 1 0 DENN (AEX-3) domain PGM_PMM_I PF02878.16 EFA79896.1 - 8.1e-37 126.0 0.0 6e-36 123.2 0.0 2.1 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EFA79896.1 - 4.5e-23 81.8 0.0 1.3e-22 80.3 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFA79896.1 - 3.7e-15 56.1 0.0 7e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EFA79896.1 - 2.6e-06 27.5 0.0 7.6e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain THF_DHG_CYH PF00763.23 EFA79897.1 - 8.3e-22 77.6 0.1 1.5e-21 76.8 0.1 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EFA79897.1 - 4.6e-18 65.1 0.9 1.1e-15 57.4 0.9 3.1 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DpaA_N PF16924.5 EFA79897.1 - 0.024 14.7 0.0 0.17 12.0 0.0 2.2 2 0 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain UDPG_MGDP_dh_N PF03721.14 EFA79897.1 - 0.032 13.8 0.3 3 7.4 0.2 2.9 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Abhydro_lipase PF04083.16 EFA79898.1 - 4.8e-18 64.5 0.0 9.5e-18 63.5 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFA79898.1 - 7e-14 52.1 0.0 1.2e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF4868 PF16162.5 EFA79898.1 - 0.083 12.8 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4868) Hydrolase_4 PF12146.8 EFA79898.1 - 0.094 12.0 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 VirJ PF06057.11 EFA79898.1 - 0.12 12.3 0.0 5 6.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) RNase_HII PF01351.18 EFA79899.1 - 8e-37 127.0 11.0 1.3e-36 126.3 0.2 3.6 3 1 0 3 3 3 1 Ribonuclease HII ubiquitin PF00240.23 EFA79899.1 - 1.5e-08 34.3 1.4 3.1e-08 33.2 0.5 2.1 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 EFA79899.1 - 0.00041 20.8 0.1 0.00041 20.8 0.1 3.1 3 0 0 3 3 3 1 Ubiquitin-like domain RBR PF17208.3 EFA79899.1 - 0.64 10.8 4.6 1.8 9.3 4.6 1.8 1 0 0 1 1 1 0 RNA binding Region Ycf15 PF10705.9 EFA79900.1 - 0.0053 16.9 0.0 1.7 8.8 0.0 2.3 2 0 0 2 2 2 2 Chloroplast protein precursor Ycf15 putative DUF726 PF05277.12 EFA79901.1 - 3.9e-70 236.5 2.1 7.3e-70 235.6 2.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF726) VPS9 PF02204.18 EFA79901.1 - 4.5e-11 42.9 0.1 1.7e-09 37.8 0.1 3.1 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain HSP20 PF00011.21 EFA79902.1 - 5.5e-10 39.3 5.1 0.00024 21.2 0.0 3.3 1 1 2 3 3 3 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA79902.1 - 0.005 16.4 0.0 0.025 14.1 0.0 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA DUF3439 PF11921.8 EFA79902.1 - 0.82 9.7 7.9 16 5.5 0.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) bZIP_1 PF00170.21 EFA79904.1 - 1.2e-09 38.1 11.7 1.2e-09 38.1 11.7 2.4 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFA79904.1 - 0.00025 21.1 12.8 0.00025 21.1 12.8 2.3 2 0 0 2 2 2 1 Basic region leucine zipper Seryl_tRNA_N PF02403.22 EFA79904.1 - 0.082 13.1 11.6 0.19 12.0 11.6 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 EFA79904.1 - 0.098 12.9 1.4 0.18 12.0 1.4 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CYSTM PF12734.7 EFA79904.1 - 0.32 11.4 0.5 0.78 10.1 0.5 1.7 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance bZIP_Maf PF03131.17 EFA79904.1 - 9.7 6.8 19.5 0.13 12.8 10.6 2.3 1 1 1 2 2 2 0 bZIP Maf transcription factor UQ_con PF00179.26 EFA79905.1 - 8.3e-53 177.8 0.1 9.5e-53 177.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFA79905.1 - 1.9e-05 24.4 0.0 2.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFA79905.1 - 0.039 14.2 0.1 0.088 13.1 0.1 1.5 1 1 0 1 1 1 0 RWD domain Mito_carr PF00153.27 EFA79906.1 - 1.6e-62 207.5 2.3 4.1e-22 77.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFA79906.1 - 0.038 13.2 0.1 5.6 6.0 0.0 2.3 2 1 0 2 2 2 0 Gammaproteobacterial serine protease Pkinase PF00069.25 EFA79907.1 - 1.8e-41 142.3 1.6 3.2e-41 141.4 0.1 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA79907.1 - 1.6e-07 30.9 0.1 3.4e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA79907.1 - 3.6e-06 27.1 0.0 6.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Toprim_Crpt PF13342.6 EFA79907.1 - 0.82 9.7 3.6 1.6 8.7 0.7 3.2 2 1 2 4 4 4 0 C-terminal repeat of topoisomerase Mucin PF01456.17 EFA79907.1 - 5.5 7.0 14.1 11 6.1 14.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4972 PF16342.5 EFA79908.1 - 0.065 12.9 0.9 0.082 12.6 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) Las1 PF04031.13 EFA79909.1 - 8.1e-41 139.7 0.8 8.1e-41 139.7 0.8 2.5 2 0 0 2 2 2 1 Las1-like DUF4604 PF15377.6 EFA79909.1 - 2.3 8.6 13.2 3.7 8.0 12.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) SR-25 PF10500.9 EFA79910.1 - 5.7e-05 22.8 11.7 6.5e-05 22.7 11.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4972 PF16342.5 EFA79912.1 - 0.065 12.9 0.9 0.082 12.6 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) ADP_ribosyl_GH PF03747.14 EFA79914.1 - 4.4e-38 131.7 0.0 6.4e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase DUF3627 PF12299.8 EFA79914.1 - 0.69 10.0 5.1 12 6.1 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3627) CLU PF13236.6 EFA79915.1 - 3.9e-53 180.5 0.0 7.7e-53 179.6 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria TPR_12 PF13424.6 EFA79915.1 - 6.2e-33 112.9 1.0 9.8e-13 48.2 0.0 4.2 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFA79915.1 - 1.5e-14 53.3 1.7 0.0011 18.8 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA79915.1 - 1.7e-12 46.6 11.5 0.00041 20.1 0.3 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA79915.1 - 3.2e-11 42.5 11.5 0.00028 20.8 0.3 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA79915.1 - 3e-09 36.3 0.4 0.00065 19.6 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat eIF3_p135 PF12807.7 EFA79915.1 - 1.5e-07 31.6 0.0 1.5e-07 31.6 0.0 2.6 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 TPR_8 PF13181.6 EFA79915.1 - 5.8e-06 26.1 22.5 0.0026 17.8 1.2 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFA79915.1 - 0.00092 19.7 3.9 2 9.2 0.1 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat CHDCT2 PF08074.11 EFA79915.1 - 0.002 18.4 0.5 0.008 16.4 0.5 2.1 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain PBD PF00786.28 EFA79915.1 - 0.089 13.2 0.3 0.71 10.3 0.0 2.6 2 0 0 2 2 2 0 P21-Rho-binding domain TPR_17 PF13431.6 EFA79915.1 - 0.18 12.2 3.5 20 5.8 0.1 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2225 PF09986.9 EFA79915.1 - 0.3 10.8 6.3 2.1 8.0 1.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Fis1_TPR_C PF14853.6 EFA79915.1 - 0.69 10.0 4.0 70 3.6 0.1 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EFA79915.1 - 2.4 7.9 5.4 1.2 8.9 0.7 2.7 2 0 0 2 2 2 0 TPR repeat IPK PF03770.16 EFA79916.1 - 3.2e-51 174.0 0.2 3.2e-51 174.0 0.2 1.7 2 0 0 2 2 2 1 Inositol polyphosphate kinase Tim17 PF02466.19 EFA79918.1 - 9.2e-26 90.4 10.6 1.4e-25 89.8 10.6 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_Omp PF13488.6 EFA79918.1 - 5.1 7.2 20.8 0.32 11.0 1.8 3.0 2 1 1 3 3 3 0 Glycine zipper LRR_6 PF13516.6 EFA79919.1 - 1.2e-18 65.5 21.7 0.0029 17.5 0.1 8.9 9 0 0 9 9 9 6 Leucine Rich repeat LRR_1 PF00560.33 EFA79919.1 - 0.016 15.7 13.2 29 5.7 1.4 7.3 7 2 0 7 7 7 0 Leucine Rich Repeat RNA_pol_Rpc4 PF05132.14 EFA79919.1 - 0.16 12.4 0.6 0.28 11.6 0.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 RRM_1 PF00076.22 EFA79920.1 - 1.2e-38 130.7 0.9 5.6e-15 54.9 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EFA79920.1 - 3.7e-10 40.8 1.8 5.3e-09 37.0 1.8 2.6 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_5 PF13893.6 EFA79920.1 - 5.5e-09 35.7 0.6 0.0002 21.0 0.3 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA79920.1 - 1.3e-07 31.4 0.1 5.4e-05 23.0 0.0 3.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EFA79920.1 - 3.6e-05 23.7 0.5 0.00053 20.0 0.0 2.9 3 1 0 3 3 3 1 RNA binding motif RL PF17797.1 EFA79920.1 - 0.0016 18.3 2.7 0.37 10.8 0.1 3.5 3 1 0 3 3 3 1 RL domain RRM_7 PF16367.5 EFA79920.1 - 0.0023 18.0 0.1 12 6.1 0.0 3.8 3 1 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EFA79920.1 - 0.015 15.3 0.8 2.6 8.1 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif GST_N_4 PF17172.4 EFA79921.1 - 3.9e-23 82.1 0.0 8.9e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EFA79921.1 - 1.7e-15 56.6 0.0 3.3e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA79921.1 - 3.1e-11 43.2 0.0 5.7e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EFA79921.1 - 1.3e-06 28.8 0.0 2.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_3 PF13417.6 EFA79921.1 - 2.1e-06 28.0 0.0 1e-05 25.8 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA79921.1 - 5.1e-05 23.4 0.0 9.8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFA79921.1 - 0.071 13.4 0.0 0.51 10.7 0.0 2.2 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 EFA79921.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_C PF00043.25 EFA79921.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 EFA79922.1 - 3.8e-21 75.4 32.1 1.1e-12 47.6 3.6 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA79922.1 - 5.3e-09 35.5 13.4 6.8e-08 31.8 0.1 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EFA79922.1 - 0.0029 16.1 0.0 0.0029 16.1 0.0 2.2 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EFA79922.1 - 0.32 9.3 6.3 0.94 7.8 1.9 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector Syntaxin_2 PF14523.6 EFA79923.1 - 3.5e-19 69.1 12.7 3.5e-19 69.1 12.7 3.0 2 1 1 3 3 3 1 Syntaxin-like protein SNARE PF05739.19 EFA79923.1 - 3.8e-11 42.8 0.5 1.4e-10 41.0 0.1 2.2 2 0 0 2 2 2 1 SNARE domain ALMT PF11744.8 EFA79923.1 - 0.0016 17.4 11.2 0.0022 16.9 11.2 1.2 1 0 0 1 1 1 1 Aluminium activated malate transporter Syntaxin PF00804.25 EFA79923.1 - 0.0036 17.0 21.1 0.016 14.9 21.1 2.4 1 1 0 1 1 1 1 Syntaxin RAMP4 PF06624.12 EFA79923.1 - 0.044 13.9 0.0 0.27 11.3 0.0 2.4 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF1664 PF07889.12 EFA79923.1 - 0.73 9.9 10.7 0.16 12.0 2.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) MutS_III PF05192.18 EFA79923.1 - 1.1 9.5 6.9 0.23 11.7 1.1 2.0 2 0 0 2 2 2 0 MutS domain III DUF5572 PF17733.1 EFA79924.1 - 0.3 11.0 8.7 1.7 8.6 0.9 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5572) SPC22 PF04573.12 EFA79926.1 - 5.5e-45 152.9 0.3 6.3e-45 152.7 0.3 1.0 1 0 0 1 1 1 1 Signal peptidase subunit CBP4 PF07960.11 EFA79927.1 - 0.41 10.5 6.4 3.6 7.5 2.2 2.8 1 1 0 2 2 2 0 CBP4 p450 PF00067.22 EFA79928.1 - 6.4e-110 368.0 0.0 1.8e-36 125.9 0.0 4.0 3 1 1 4 4 4 4 Cytochrome P450 eRF1_2 PF03464.15 EFA79928.1 - 0.0046 17.3 0.0 1.6 9.1 0.0 2.7 2 0 0 2 2 2 2 eRF1 domain 2 Vps51 PF08700.11 EFA79928.1 - 0.053 13.6 0.9 13 5.9 0.1 2.5 2 0 0 2 2 2 0 Vps51/Vps67 IpgD PF05925.12 EFA79928.1 - 0.092 11.3 0.0 9.1 4.7 0.0 2.1 2 0 0 2 2 2 0 Enterobacterial virulence protein IpgD GRIP PF01465.20 EFA79928.1 - 0.13 12.2 0.4 24 5.0 0.1 2.5 2 0 0 2 2 2 0 GRIP domain bPH_3 PF14470.6 EFA79929.1 - 0.094 13.1 6.1 0.13 12.6 2.5 2.7 2 0 0 2 2 2 0 Bacterial PH domain GST_C_3 PF14497.6 EFA79930.1 - 9.3e-21 73.9 0.2 1.5e-20 73.2 0.2 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA79930.1 - 4.4e-12 46.2 0.0 2.4e-11 43.8 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA79930.1 - 7.4e-08 32.5 0.0 1.3e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA79930.1 - 5.4e-05 23.1 0.0 0.00016 21.6 0.0 1.9 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA79930.1 - 0.017 14.9 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ank_2 PF12796.7 EFA79931.1 - 1.9e-24 86.0 2.4 1.6e-07 31.8 0.1 6.3 2 2 5 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79931.1 - 5e-24 84.4 7.6 1.1e-06 29.1 0.1 7.4 5 3 2 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79931.1 - 5.2e-20 71.3 8.6 0.00011 22.3 0.1 9.9 4 2 7 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79931.1 - 1.3e-17 62.0 6.6 0.014 15.9 0.1 11.5 12 0 0 12 12 12 3 Ankyrin repeat Ank PF00023.30 EFA79931.1 - 7.6e-06 26.1 3.0 0.67 10.5 0.1 6.8 5 2 0 5 5 5 1 Ankyrin repeat Ank_2 PF12796.7 EFA79932.1 - 6e-30 103.7 11.6 9.8e-09 35.7 0.1 6.6 3 1 6 9 9 9 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79932.1 - 1.6e-23 82.8 7.4 0.00022 21.7 0.1 7.5 4 1 5 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA79932.1 - 8.3e-23 80.2 11.5 0.0049 17.2 0.1 10.2 4 2 6 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79932.1 - 2.9e-14 51.8 12.1 4.8 8.1 0.0 11.3 12 0 0 12 12 12 4 Ankyrin repeat Ank PF00023.30 EFA79932.1 - 2.4e-05 24.6 3.7 19 5.9 0.2 7.3 7 2 1 8 8 8 1 Ankyrin repeat DUF3447 PF11929.8 EFA79932.1 - 0.0049 16.8 6.7 4.4 7.3 0.1 4.9 4 1 0 4 4 4 2 Domain of unknown function (DUF3447) Phage_T7_Capsid PF05396.11 EFA79932.1 - 0.07 13.5 0.3 3.3 8.1 0.0 2.9 3 1 0 3 3 3 0 Phage T7 capsid assembly protein LBP_BPI_CETP_C PF02886.17 EFA79933.1 - 9.6e-08 31.8 3.9 1.9e-07 30.8 3.9 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain DUF5374 PF17344.2 EFA79933.1 - 0.12 12.3 2.0 0.2 11.6 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5374) GRASP55_65 PF04495.14 EFA79935.1 - 0.021 15.1 0.0 12 6.2 0.0 2.5 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain Peptidase_M23_N PF18421.1 EFA79935.1 - 0.023 14.6 0.0 7.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Peptidase family M23 N-terminal domain DUF3902 PF13042.6 EFA79935.1 - 0.053 13.1 0.2 12 5.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3902) DsbD PF02683.15 EFA79935.1 - 0.093 12.6 0.1 18 5.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome C biogenesis protein transmembrane region Cys_Met_Meta_PP PF01053.20 EFA79937.1 - 1.7e-152 507.4 0.0 1.9e-152 507.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFA79937.1 - 2.1e-08 33.8 0.1 3.3e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 EFA79937.1 - 1.8e-05 23.5 0.0 2.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_5 PF00266.19 EFA79937.1 - 7.9e-05 21.8 0.0 0.00012 21.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFA79937.1 - 9.8e-05 21.8 0.0 0.00027 20.4 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Las1 PF04031.13 EFA79937.1 - 0.12 12.5 0.0 0.57 10.3 0.0 1.9 2 0 0 2 2 2 0 Las1-like Snapin_Pallidin PF14712.6 EFA79938.1 - 1e-16 61.1 9.0 1e-16 61.1 9.0 3.9 3 2 0 3 3 3 1 Snapin/Pallidin Pex14_N PF04695.13 EFA79938.1 - 4.1 8.0 17.3 3.4 8.3 6.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Fringe PF02434.16 EFA79940.1 - 9.7e-06 25.2 0.9 0.00031 20.2 0.9 2.1 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EFA79940.1 - 0.0048 16.7 0.0 0.0073 16.1 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Glycos_transf_2 PF00535.26 EFA79940.1 - 0.12 12.2 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 2 PROCN PF08083.11 EFA79942.1 - 4e-223 740.5 6.6 6.2e-223 739.8 6.6 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EFA79942.1 - 4.5e-116 386.4 0.3 8.7e-116 385.4 0.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U5_2-snRNA_bdg PF10597.9 EFA79942.1 - 2.2e-71 238.2 0.1 4.1e-71 237.3 0.1 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 U6-snRNA_bdg PF10596.9 EFA79942.1 - 5.7e-66 221.4 1.7 1.1e-65 220.4 1.7 1.5 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PROCT PF08084.11 EFA79942.1 - 4.1e-47 159.1 0.8 1.9e-46 157.0 0.7 2.2 2 0 0 2 2 2 1 PROCT (NUC072) domain RRM_4 PF10598.9 EFA79942.1 - 2.8e-46 155.8 0.4 9.3e-46 154.1 0.4 2.0 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PRO8NT PF08082.11 EFA79942.1 - 1.3e-39 135.6 8.6 1.2e-24 87.0 3.6 2.7 1 1 1 2 2 2 2 PRO8NT (NUC069), PrP8 N-terminal domain JAB PF01398.21 EFA79942.1 - 4.6e-07 29.8 0.0 1.5e-06 28.2 0.0 2.0 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease EF-hand_6 PF13405.6 EFA79943.1 - 3.5e-25 85.8 8.9 2.9e-06 26.7 0.9 4.7 4 1 1 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 EFA79943.1 - 1.8e-24 85.9 10.8 2.5e-12 47.0 0.8 2.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFA79943.1 - 9.1e-24 81.2 11.2 1.6e-06 27.3 0.1 4.4 4 1 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 EFA79943.1 - 8.7e-15 53.5 11.7 0.00021 20.6 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFA79943.1 - 3e-13 49.4 7.5 0.0004 20.2 0.3 4.2 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA79943.1 - 1.6e-05 25.2 1.7 0.19 12.0 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFA79943.1 - 5.7e-05 23.0 3.0 0.045 13.7 0.1 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EFA79943.1 - 0.0002 21.1 4.2 0.5 10.3 0.4 3.8 4 0 0 4 4 4 2 EF hand Poxvirus PF06227.12 EFA79943.1 - 0.00076 19.3 0.5 0.0015 18.3 0.3 1.6 1 1 0 1 1 1 1 dsDNA Poxvirus EF-hand_11 PF08976.11 EFA79943.1 - 0.0026 18.6 0.1 0.034 15.0 0.0 2.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_9 PF14658.6 EFA79943.1 - 0.013 15.8 0.1 1.2 9.5 0.0 2.4 2 1 0 2 2 2 0 EF-hand domain DUF4050 PF13259.6 EFA79944.1 - 0.002 18.5 0.0 0.002 18.5 0.0 2.4 2 1 1 3 3 3 1 Protein of unknown function (DUF4050) Na_Ca_ex_C PF16494.5 EFA79944.1 - 0.071 13.6 0.2 0.12 12.8 0.2 1.3 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain DUF604 PF04646.12 EFA79944.1 - 0.24 10.8 2.2 0.29 10.5 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF604 FGase PF05013.12 EFA79945.1 - 7.9e-06 26.2 0.1 0.00018 21.8 0.2 2.2 2 0 0 2 2 2 2 N-formylglutamate amidohydrolase Guanylate_cyc PF00211.20 EFA79946.1 - 5.9e-56 189.0 0.0 9.5e-56 188.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CHASE PF03924.13 EFA79946.1 - 1.4e-15 57.8 0.0 2.6e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 CHASE domain IMS PF00817.20 EFA79946.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 impB/mucB/samB family Saf_2TM PF18303.1 EFA79946.1 - 0.29 10.7 0.8 25 4.4 0.1 2.7 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF4271 PF14093.6 EFA79946.1 - 3.1 7.7 9.3 7.3 6.4 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) Ank_2 PF12796.7 EFA79947.1 - 1.8e-124 406.6 24.8 2e-17 63.6 0.1 11.7 4 2 11 15 15 15 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA79947.1 - 5.9e-100 326.5 25.0 5e-10 39.7 0.0 15.4 4 3 10 15 15 15 15 Ankyrin repeats (many copies) Ank PF00023.30 EFA79947.1 - 7.7e-92 298.1 32.1 8.4e-06 26.0 0.0 19.1 19 0 0 19 19 19 18 Ankyrin repeat Ank_5 PF13857.6 EFA79947.1 - 2.9e-88 288.8 22.8 9.3e-11 41.8 0.1 16.4 6 6 13 19 19 19 16 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA79947.1 - 1.4e-81 258.6 23.9 0.00035 20.8 0.1 20.4 21 0 0 21 21 21 16 Ankyrin repeat SUIM_assoc PF16619.5 EFA79947.1 - 1 9.5 15.0 0.026 14.6 6.1 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 eIF3g PF12353.8 EFA79948.1 - 6.6e-22 78.2 3.6 1.5e-21 77.1 3.6 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EFA79948.1 - 7.5e-18 64.1 0.4 3.2e-17 62.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA79948.1 - 0.0001 21.9 0.0 0.00023 20.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA79948.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Cytomega_UL84 PF06284.11 EFA79949.1 - 0.053 12.0 0.0 0.082 11.4 0.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein LepA_C PF06421.12 EFA79951.1 - 7e-46 154.8 2.1 1.3e-45 154.0 2.1 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EFA79951.1 - 2.1e-16 59.7 0.0 3.6e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 EFA79951.1 - 0.0033 17.3 0.2 0.16 11.8 0.0 2.4 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain Ras PF00071.22 EFA79952.1 - 4.3e-57 192.2 1.0 2.9e-56 189.6 0.7 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFA79952.1 - 1.4e-32 112.4 0.8 3.1e-31 108.1 0.2 2.9 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFA79952.1 - 7.4e-31 107.2 3.1 6e-24 84.7 0.1 2.9 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 EFA79952.1 - 6.7e-14 51.7 0.1 1.8e-13 50.3 0.1 1.7 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFA79952.1 - 2.2e-08 33.7 1.8 0.00027 20.4 0.1 3.6 2 1 1 3 3 3 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFA79952.1 - 3.1e-08 33.7 0.4 9.5e-05 22.5 0.1 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFA79952.1 - 3.4e-06 27.3 0.5 7.8e-06 26.2 0.5 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Gtr1_RagA PF04670.12 EFA79952.1 - 0.00033 20.1 0.2 0.00072 19.0 0.1 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA79952.1 - 0.0018 18.2 1.8 1.2 9.0 0.0 3.2 3 1 0 4 4 4 2 RsgA GTPase Septin PF00735.18 EFA79952.1 - 0.0033 16.7 0.1 1.2 8.4 0.0 2.3 2 0 0 2 2 2 2 Septin FeoB_N PF02421.18 EFA79952.1 - 0.0037 16.8 0.1 0.22 11.0 0.1 3.5 2 1 0 2 2 2 1 Ferrous iron transport protein B TniB PF05621.11 EFA79952.1 - 0.0076 15.7 0.0 0.046 13.1 0.0 2.0 2 0 0 2 2 2 1 Bacterial TniB protein PduV-EutP PF10662.9 EFA79952.1 - 0.034 13.9 0.7 3.4 7.4 0.0 3.4 3 1 1 4 4 4 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.14 EFA79952.1 - 0.058 13.3 1.0 5.2 7.0 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EFA79952.1 - 0.11 12.9 0.1 0.53 10.6 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain DUF3439 PF11921.8 EFA79954.1 - 0.1 12.6 4.5 0.069 13.1 2.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) NPA PF16469.5 EFA79954.1 - 0.3 11.7 1.8 6.9 7.3 0.2 2.5 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 RRM_4 PF10598.9 EFA79955.1 - 0.021 15.2 0.2 0.079 13.3 0.2 2.0 1 0 0 1 1 1 0 RNA recognition motif of the spliceosomal PrP8 F-box PF00646.33 EFA79957.1 - 0.21 11.5 1.0 0.44 10.5 0.1 2.1 2 0 0 2 2 2 0 F-box domain Sid-5 PF17204.3 EFA79958.1 - 0.98 9.6 3.6 1.2 9.3 0.5 2.5 2 1 1 3 3 3 0 Sid-5 family DUF4064 PF13273.6 EFA79958.1 - 3.6 7.9 13.2 3.8 7.8 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) SLC3A2_N PF16028.5 EFA79958.1 - 4.2 7.0 6.5 0.55 9.8 0.3 2.4 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus DUF1768 PF08719.11 EFA79960.1 - 1.4e-33 116.5 0.0 2.2e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Zn_Tnp_IS1595 PF12760.7 EFA79961.1 - 0.007 16.3 0.0 0.0083 16.1 0.0 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rad50_zn_hook PF04423.14 EFA79961.1 - 0.0082 16.0 2.9 0.044 13.6 2.5 2.0 1 1 1 2 2 2 1 Rad50 zinc hook motif Prok-RING_4 PF14447.6 EFA79961.1 - 0.02 14.7 0.1 0.026 14.4 0.1 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Vps39_2 PF10367.9 EFA79961.1 - 0.066 13.7 0.0 0.071 13.6 0.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 YdjO PF14169.6 EFA79961.1 - 0.1 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Cold-inducible protein YdjO H_lectin PF09458.10 EFA79962.1 - 3.7e-09 36.6 0.9 3.7e-09 36.6 0.9 2.1 1 1 1 2 2 2 1 H-type lectin domain Ribosomal_S6e PF01092.19 EFA79964.1 - 6.4e-42 142.5 0.0 1.6e-41 141.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S6e Sybindin PF04099.12 EFA79964.1 - 5.1e-38 130.2 0.6 1.1e-37 129.2 0.6 1.5 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFA79964.1 - 0.00062 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region GTP_EFTU PF00009.27 EFA79965.1 - 1.5e-32 112.7 1.7 3.2e-32 111.7 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFA79965.1 - 1.8e-13 50.5 0.3 1.8e-13 50.5 0.3 2.5 3 0 0 3 3 3 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EFA79965.1 - 5.9e-13 49.0 3.1 1.6e-08 34.8 0.2 3.7 2 0 0 2 2 2 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFA79965.1 - 9.5e-12 44.7 0.0 2.8e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EFA79965.1 - 4.3e-07 30.0 0.1 4.3e-07 30.0 0.1 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EFA79965.1 - 0.00018 21.7 0.0 0.00085 19.5 0.0 2.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFA79965.1 - 0.00063 19.6 0.0 0.00063 19.6 0.0 2.2 2 1 0 2 2 2 1 Conserved hypothetical ATP binding protein LytR_C PF13399.6 EFA79965.1 - 0.041 14.9 0.2 0.48 11.4 0.2 3.0 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator RsgA_GTPase PF03193.16 EFA79965.1 - 0.1 12.5 3.3 0.43 10.5 0.4 2.9 2 1 0 2 2 2 0 RsgA GTPase DUF1108 PF06531.11 EFA79965.1 - 2.9 8.3 5.2 1.9 8.8 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1108) GTP_EFTU PF00009.27 EFA79966.1 - 5.3e-44 150.1 0.0 8.1e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EFA79966.1 - 5e-27 94.9 6.9 5e-27 94.9 6.9 2.0 2 0 0 2 2 2 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EFA79966.1 - 5.3e-22 77.9 0.0 1e-21 76.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFA79966.1 - 3.8e-20 71.7 0.0 7.4e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EFA79966.1 - 8.3e-08 32.2 0.1 2.7e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFA79966.1 - 2e-05 24.9 0.1 6e-05 23.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFA79966.1 - 0.00016 21.7 0.1 0.0003 20.8 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EFA79966.1 - 0.0003 20.1 0.0 0.00067 19.0 0.0 1.5 1 0 0 1 1 1 1 Septin Roc PF08477.13 EFA79966.1 - 0.0051 17.0 0.1 0.035 14.3 0.1 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA79966.1 - 0.026 13.9 0.1 0.14 11.6 0.1 2.0 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 EFA79966.1 - 0.13 12.3 1.7 3.6 7.6 0.1 2.5 1 1 1 2 2 2 0 Dynamin family Ras PF00071.22 EFA79966.1 - 0.16 11.5 0.1 0.45 10.1 0.1 1.7 1 1 0 1 1 1 0 Ras family VWA_2 PF13519.6 EFA79967.1 - 4.1e-08 33.8 4.4 8.5e-08 32.8 1.3 2.8 2 1 0 2 2 2 1 von Willebrand factor type A domain Tim54 PF11711.8 EFA79967.1 - 0.44 9.3 4.6 0.4 9.4 0.9 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Pex14_N PF04695.13 EFA79967.1 - 5.6 7.6 23.1 2.9 8.5 7.9 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AAR2 PF05282.11 EFA79968.1 - 2.4e-102 342.9 7.2 1.5e-101 340.4 7.2 1.9 1 1 0 1 1 1 1 AAR2 protein Ferlin_C PF16165.5 EFA79968.1 - 0.13 12.2 3.1 3.7 7.5 0.0 2.5 2 0 0 2 2 2 0 Ferlin C-terminus DUF4502 PF14950.6 EFA79968.1 - 4.1 6.7 13.2 3.9 6.8 2.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4502) EGF_2 PF07974.13 EFA79969.1 - 0.0081 16.5 13.4 0.016 15.6 13.4 1.5 1 0 0 1 1 1 1 EGF-like domain DUF2043 PF09740.9 EFA79970.1 - 2e-27 95.9 0.0 2e-27 95.9 0.0 3.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2043) FNIP PF05725.12 EFA79970.1 - 8.2e-23 80.3 1.7 0.00018 21.6 0.8 6.7 4 2 1 5 5 5 5 FNIP Repeat Mucin PF01456.17 EFA79970.1 - 0.024 14.6 5.8 0.045 13.7 5.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein F-box_5 PF18511.1 EFA79970.1 - 0.071 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 F-box DUF3439 PF11921.8 EFA79970.1 - 0.73 9.8 3.9 1.7 8.6 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Zip PF02535.22 EFA79971.1 - 5.9e-31 107.9 0.1 5.9e-31 107.9 0.1 2.0 1 1 1 2 2 2 1 ZIP Zinc transporter Stevor PF17410.2 EFA79971.1 - 0.048 13.2 4.1 0.076 12.5 4.1 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame RNA_pol_Rpc4 PF05132.14 EFA79971.1 - 0.057 13.8 1.0 0.11 12.9 1.0 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 SID-1_RNA_chan PF13965.6 EFA79971.1 - 0.15 10.5 0.2 0.26 9.7 0.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ASD2 PF08687.11 EFA79971.1 - 0.72 9.4 8.3 1 8.9 8.3 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 CDC45 PF02724.14 EFA79971.1 - 1.4 7.1 10.2 1.8 6.7 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 EFA79971.1 - 1.5 7.7 6.5 2.1 7.2 6.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PPL5 PF18168.1 EFA79971.1 - 2.4 7.4 8.6 3.4 6.9 8.6 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Presenilin PF01080.17 EFA79971.1 - 2.5 6.7 10.5 0.025 13.4 0.5 2.0 2 0 0 2 2 2 0 Presenilin DUF2076 PF09849.9 EFA79971.1 - 4.8 7.1 11.5 1.4 8.9 8.3 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) NPR3 PF03666.13 EFA79971.1 - 5.5 5.7 13.8 7.9 5.1 13.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Actin PF00022.19 EFA79972.1 - 4.5e-88 295.6 0.0 6.2e-87 291.8 0.0 2.0 1 1 0 1 1 1 1 Actin SAPS PF04499.15 EFA79972.1 - 0.042 12.6 8.2 0.069 11.9 8.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 EFA79972.1 - 0.12 11.5 1.4 0.19 10.9 1.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5523 PF17661.1 EFA79972.1 - 0.13 11.9 10.0 0.81 9.3 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Menin PF05053.13 EFA79972.1 - 0.18 10.1 9.8 0.26 9.6 9.8 1.1 1 0 0 1 1 1 0 Menin Nop14 PF04147.12 EFA79972.1 - 0.5 8.5 10.8 0.68 8.1 10.8 1.1 1 0 0 1 1 1 0 Nop14-like family Mem_trans PF03547.18 EFA79972.1 - 3.1 6.1 6.3 16 3.7 5.6 1.9 1 1 1 2 2 2 0 Membrane transport protein NOA36 PF06524.12 EFA79972.1 - 9.1 5.5 10.7 17 4.6 10.7 1.4 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 EFA79972.1 - 9.9 4.8 9.0 15 4.3 9.0 1.1 1 0 0 1 1 1 0 Presenilin ubiquitin PF00240.23 EFA79973.1 - 1.2e-132 431.8 20.3 7.9e-33 112.0 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EFA79973.1 - 1.3e-61 204.3 19.5 5.7e-15 54.9 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA79973.1 - 3.1e-22 78.8 9.9 0.00071 20.0 0.1 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA79973.1 - 3.1e-15 56.3 5.9 0.035 14.4 0.1 4.1 1 1 2 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA79973.1 - 8e-15 54.5 3.9 0.058 13.3 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA79973.1 - 1.4e-13 50.9 2.1 0.21 11.7 0.0 4.9 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFA79973.1 - 1.2e-12 48.3 0.5 0.49 11.0 0.0 4.2 1 1 1 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFA79973.1 - 6e-08 32.7 0.3 3.8 7.3 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EFA79973.1 - 1.1e-06 28.6 22.3 25 5.0 0.0 7.9 8 0 0 8 8 8 0 Ubiquitin-like domain DUF2870 PF11069.8 EFA79973.1 - 4.1e-06 27.1 0.0 28 5.2 0.0 4.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EFA79973.1 - 4.9e-06 26.0 0.8 2 7.7 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase DUF3861 PF12977.7 EFA79973.1 - 5.3e-05 23.3 1.1 26 5.1 0.0 4.2 1 1 3 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) Big_3_3 PF13750.6 EFA79973.1 - 5.7e-05 22.8 0.1 22 4.7 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) DUF969 PF06149.12 EFA79973.1 - 8.2e-05 22.1 0.0 18 4.7 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF969) UDP-g_GGTase PF06427.11 EFA79973.1 - 0.00013 22.1 4.9 5.9 7.1 0.1 4.0 4 0 0 4 4 4 3 UDP-glucose:Glycoprotein Glucosyltransferase DUF3435 PF11917.8 EFA79973.1 - 0.0003 19.8 0.6 21 3.9 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3435) ACT_5 PF13710.6 EFA79973.1 - 0.00061 19.6 3.7 31 4.5 0.0 4.3 4 0 0 4 4 4 0 ACT domain Big_7 PF17957.1 EFA79973.1 - 0.00068 20.4 0.0 1.1e+02 3.7 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain YcgR_2 PF12945.7 EFA79973.1 - 0.0014 18.7 6.6 30 4.8 0.1 4.3 4 0 0 4 4 4 0 Flagellar protein YcgR Corona_NS2A PF05213.12 EFA79973.1 - 0.002 17.5 0.1 49 3.2 0.0 3.9 4 0 0 4 4 4 0 Coronavirus NS2A protein Raf1_HTH PF18579.1 EFA79973.1 - 0.0038 16.9 0.2 1e+02 2.7 0.0 4.2 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain Imm12 PF15560.6 EFA79973.1 - 0.0049 16.8 1.4 74 3.3 0.0 4.0 4 0 0 4 4 4 0 Immunity protein 12 ACT_4 PF13291.6 EFA79973.1 - 0.0071 16.9 0.1 1.8e+02 2.8 0.0 4.2 4 0 0 4 4 4 0 ACT domain ORF11CD3 PF10549.9 EFA79973.1 - 0.018 15.2 1.8 1.4e+02 2.7 0.0 5.3 8 0 0 8 8 4 0 ORF11CD3 domain NEAT PF05031.12 EFA79973.1 - 0.07 13.7 6.6 1.8e+02 2.7 6.6 3.8 1 1 0 1 1 1 0 Iron Transport-associated domain HcyBio PF01837.16 EFA79973.1 - 0.075 11.9 7.1 12 4.7 0.1 3.6 4 0 0 4 4 4 0 Homocysteine biosynthesis enzyme, sulfur-incorporation Myosin_N PF02736.19 EFA79973.1 - 0.15 11.9 8.3 61 3.6 0.1 5.4 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain ProRS-C_2 PF09181.10 EFA79973.1 - 1.3 9.3 5.7 2e+02 2.2 0.1 4.0 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal PH_15 PF17339.2 EFA79973.1 - 3.1 7.7 7.0 79 3.2 0.1 3.6 4 0 0 4 4 4 0 PH domain fn3 PF00041.21 EFA79974.1 - 1.5e-26 92.5 29.3 0.00012 22.3 0.2 8.3 7 1 0 7 7 7 6 Fibronectin type III domain Tissue_fac PF01108.17 EFA79974.1 - 2e-05 24.4 17.1 0.087 12.7 0.0 7.0 7 1 0 7 7 7 3 Tissue factor Pur_ac_phosph_N PF16656.5 EFA79974.1 - 3.5e-05 24.3 41.2 0.21 12.2 0.2 9.2 5 3 2 7 7 7 3 Purple acid Phosphatase, N-terminal domain Arylsulfotran_N PF17425.2 EFA79974.1 - 0.00015 21.8 18.2 0.041 13.9 3.2 5.7 3 1 1 4 4 4 2 Arylsulfotransferase Ig-like domain EGF_2 PF07974.13 EFA79974.1 - 0.00029 21.1 19.1 0.00087 19.6 19.1 1.9 1 0 0 1 1 1 1 EGF-like domain DUF2369 PF10179.9 EFA79974.1 - 0.00035 20.9 27.8 5.9 7.4 0.6 7.9 8 0 0 8 8 8 4 Uncharacterised conserved protein (DUF2369) EB PF01683.18 EFA79974.1 - 0.78 10.1 10.1 0.027 14.8 3.2 2.2 2 0 0 2 2 2 0 EB module fn3 PF00041.21 EFA79975.1 - 1.2e-35 121.7 29.9 9.8e-05 22.6 0.2 13.6 13 1 0 13 13 13 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EFA79975.1 - 9.9e-07 29.3 48.6 5.8 7.6 0.2 12.8 9 3 0 11 11 11 6 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.13 EFA79975.1 - 2.2e-05 24.7 52.1 0.00085 19.6 19.0 3.2 3 0 0 3 3 3 2 EGF-like domain EB PF01683.18 EFA79975.1 - 0.0017 18.6 21.9 0.014 15.7 2.3 3.5 3 0 0 3 3 3 2 EB module nsp8 PF08717.10 EFA79975.1 - 0.0036 17.2 1.0 2.5 8.0 0.1 3.0 3 0 0 3 3 3 2 nsp8 replicase Tissue_fac PF01108.17 EFA79975.1 - 0.011 15.5 26.2 0.57 10.1 0.1 8.6 8 2 1 9 9 9 0 Tissue factor L27_1 PF09058.10 EFA79975.1 - 0.12 12.4 0.0 37 4.4 0.0 3.5 4 0 0 4 4 4 0 L27_1 Laminin_EGF PF00053.24 EFA79975.1 - 3.2 8.0 23.7 2.9 8.1 7.4 2.7 2 0 0 2 2 2 0 Laminin EGF domain ORC2 PF04084.14 EFA79977.1 - 0.029 13.3 0.5 0.036 13.0 0.5 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 2 AAA_21 PF13304.6 EFA79977.1 - 0.24 11.2 1.0 0.32 10.8 1.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system LRR_4 PF12799.7 EFA79981.1 - 0.44 11.1 6.0 1.6 9.2 0.2 3.8 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Abhydrolase_6 PF12697.7 EFA79982.1 - 7.2e-17 62.7 0.0 1.1e-16 62.1 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA79982.1 - 1.5e-08 34.6 0.6 9.2e-06 25.5 0.4 2.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EFA79982.1 - 1.7e-08 34.4 0.1 3.2e-08 33.5 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA79982.1 - 1.4e-06 27.8 0.1 4.3e-05 22.9 0.0 2.6 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EFA79982.1 - 4e-05 23.5 0.0 0.00011 22.1 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase PGAP1 PF07819.13 EFA79982.1 - 0.0017 18.1 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.20 EFA79982.1 - 0.073 13.2 0.2 0.16 12.1 0.2 1.6 1 1 0 1 1 1 0 Thioesterase domain FSH1 PF03959.13 EFA79982.1 - 0.074 12.7 0.0 0.27 10.9 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EFA79982.1 - 0.081 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 EFA79982.1 - 0.094 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Peptidase_S15 PF02129.18 EFA79982.1 - 0.15 11.6 0.1 0.38 10.3 0.0 1.7 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) EMP24_GP25L PF01105.24 EFA79983.1 - 0.65 9.9 6.1 1.8 8.4 6.1 1.9 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD AIG1 PF04548.16 EFA79985.1 - 4.7e-10 39.2 0.3 4.7e-10 39.2 0.3 2.7 2 1 1 3 3 3 1 AIG1 family MMR_HSR1 PF01926.23 EFA79985.1 - 1.8e-09 37.7 1.7 2.9e-09 37.0 0.4 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA79985.1 - 0.00033 20.6 0.5 0.00033 20.6 0.5 2.6 1 1 1 3 3 3 1 RsgA GTPase FeoB_N PF02421.18 EFA79985.1 - 0.0016 18.0 0.2 0.0029 17.2 0.2 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 EFA79985.1 - 0.0021 18.5 4.2 0.1 13.0 3.5 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 EFA79985.1 - 0.0023 17.8 8.0 0.07 12.9 0.5 2.8 2 1 1 3 3 3 2 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EFA79985.1 - 0.0058 16.7 10.5 2.7 8.0 10.4 3.2 1 1 0 1 1 1 1 Dynamin family AAA_17 PF13207.6 EFA79985.1 - 0.02 15.3 5.0 0.08 13.4 0.1 2.6 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFA79985.1 - 0.039 14.3 0.2 0.13 12.7 0.2 1.9 1 0 0 1 1 1 0 RNA helicase Rootletin PF15035.6 EFA79985.1 - 0.088 12.8 9.4 0.13 12.2 9.4 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion MeaB PF03308.16 EFA79985.1 - 0.12 11.4 0.2 0.25 10.3 0.2 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EFA79985.1 - 0.16 12.5 0.2 0.16 12.5 0.2 2.4 1 1 0 2 2 2 0 AAA domain IFNGR1 PF07140.11 EFA79985.1 - 0.17 12.0 0.1 0.17 12.0 0.1 1.8 2 1 0 2 2 2 0 Interferon gamma receptor (IFNGR1) AAA_30 PF13604.6 EFA79985.1 - 0.23 11.1 0.6 16 5.1 0.1 2.7 2 2 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA79985.1 - 0.3 11.6 9.3 2.5 8.6 9.3 2.6 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EFA79985.1 - 0.36 11.1 2.8 0.6 10.4 0.2 2.5 2 1 1 3 3 3 0 AAA domain AAA_16 PF13191.6 EFA79985.1 - 0.39 11.1 3.6 1.2 9.5 0.1 2.5 2 1 0 2 2 2 0 AAA ATPase domain SieB PF14163.6 EFA79985.1 - 3.3 7.2 9.3 4.5 6.7 0.4 2.5 1 1 0 2 2 2 0 Super-infection exclusion protein B AIG1 PF04548.16 EFA79986.1 - 0.00019 20.8 0.4 0.00019 20.8 0.4 2.1 1 1 0 2 2 2 1 AIG1 family AAA PF00004.29 EFA79986.1 - 0.0017 18.8 2.7 0.062 13.7 0.1 2.4 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF1465 PF07323.12 EFA79986.1 - 0.0074 16.1 0.3 0.015 15.2 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1465) MMR_HSR1 PF01926.23 EFA79986.1 - 0.013 15.6 1.6 0.014 15.5 0.3 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFA79986.1 - 0.017 14.9 4.2 1.1 9.0 4.1 2.1 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein Peptidase_S49_N PF08496.10 EFA79986.1 - 0.03 14.4 2.6 3 7.9 0.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Dynamin_N PF00350.23 EFA79986.1 - 0.1 12.7 1.5 0.22 11.6 0.1 2.1 2 0 0 2 2 2 0 Dynamin family CCDC85 PF10226.9 EFA79986.1 - 1.5 8.5 11.7 41 3.8 6.1 2.9 2 2 0 2 2 2 0 CCDC85 family zf-LITAF-like PF10601.9 EFA79987.1 - 2.5 8.4 6.7 21 5.5 0.5 2.9 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain RINT1_TIP1 PF04437.13 EFA79988.1 - 2.2e-63 214.9 36.0 2.8e-34 118.9 9.6 4.5 4 1 1 5 5 5 3 RINT-1 / TIP-1 family RXT2_N PF08595.11 EFA79988.1 - 2.1 8.4 9.3 0.78 9.8 3.6 2.7 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM176 PF14851.6 EFA79988.1 - 4.4 7.0 11.2 0.25 11.0 3.3 2.4 2 0 0 2 2 2 0 FAM176 family AJAP1_PANP_C PF15298.6 EFA79988.1 - 4.4 7.5 25.3 9 6.5 16.6 2.5 2 0 0 2 2 2 0 AJAP1/PANP C-terminus DUF5339 PF17274.2 EFA79988.1 - 5.4 7.9 6.9 21 6.1 3.5 3.4 2 1 0 2 2 2 0 Family of unknown function (DUF5339) Ly49 PF08391.10 EFA79989.1 - 0.0027 18.1 2.0 0.0036 17.6 2.0 1.5 1 1 0 1 1 1 1 Ly49-like protein, N-terminal region OSTbeta PF15048.6 EFA79989.1 - 0.042 14.0 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF3993 PF13158.6 EFA79989.1 - 0.044 14.0 0.0 0.049 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3993) DUF2606 PF10794.9 EFA79989.1 - 0.12 12.2 0.2 0.17 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) Dicty_REP PF05086.12 EFA79990.1 - 1.5 6.7 32.6 0.035 12.1 9.7 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein UCH PF00443.29 EFA79991.1 - 7.1e-50 169.9 17.1 7.1e-50 169.9 17.1 4.3 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA79991.1 - 6.8e-12 45.6 9.3 6.8e-12 45.6 9.3 4.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SGP PF17228.2 EFA79991.1 - 0.9 10.4 14.0 2.9 8.8 14.0 1.8 1 0 0 1 1 1 0 Sulphur globule protein TF_Zn_Ribbon PF08271.12 EFA79992.1 - 0.00021 20.7 1.8 0.00079 18.9 1.8 1.9 1 0 0 1 1 1 1 TFIIB zinc-binding zf-RRN7 PF11781.8 EFA79992.1 - 0.00046 19.8 0.1 0.00078 19.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TFIIB PF00382.19 EFA79992.1 - 0.0013 18.8 0.0 0.0063 16.5 0.0 2.0 2 0 0 2 2 2 1 Transcription factor TFIIB repeat DUF2318 PF10080.9 EFA79992.1 - 0.082 13.0 1.4 0.28 11.3 0.7 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) YhfH PF14149.6 EFA79992.1 - 0.19 11.7 1.5 14 5.8 0.3 2.5 2 0 0 2 2 2 0 YhfH-like protein Trm112p PF03966.16 EFA79992.1 - 0.94 10.1 3.3 18 6.0 0.5 3.5 3 0 0 3 3 3 0 Trm112p-like protein Myc_N PF01056.18 EFA79992.1 - 2.9 7.7 21.1 0.035 14.0 5.7 2.5 3 0 0 3 3 3 0 Myc amino-terminal region CDC45 PF02724.14 EFA79992.1 - 4.7 5.4 32.6 0.12 10.6 11.5 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF4820 PF16091.5 EFA79992.1 - 5 6.4 18.0 8.7 5.6 3.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) CobT PF06213.12 EFA79992.1 - 5.9 6.2 27.1 6.5 6.1 8.1 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TIG PF01833.24 EFA79993.1 - 1.5e-69 230.1 77.3 7.8e-13 48.3 6.6 9.5 9 0 0 9 9 9 9 IPT/TIG domain EGF_2 PF07974.13 EFA79993.1 - 0.00038 20.8 61.7 0.0011 19.3 17.5 3.9 3 0 0 3 3 3 2 EGF-like domain I-EGF_1 PF18372.1 EFA79993.1 - 0.67 10.1 45.4 0.15 12.1 13.9 4.1 3 1 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 BRCT_2 PF16589.5 EFA79994.1 - 5.4e-09 36.3 0.1 1.5e-08 34.9 0.1 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA79994.1 - 9.1e-09 35.6 0.2 2.6e-08 34.1 0.2 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFA79994.1 - 0.00033 20.6 0.0 0.00072 19.5 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_3 PF18428.1 EFA79994.1 - 0.0076 16.3 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3494 PF11999.8 EFA79994.1 - 0.1 12.2 0.5 0.35 10.5 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3494) Solute_trans_a PF03619.16 EFA79995.1 - 1.1e-56 192.3 9.9 1.3e-56 192.0 9.9 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha 7TM_GPCR_Srsx PF10320.9 EFA79995.1 - 0.034 13.5 7.8 0.035 13.5 6.9 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx ChW PF07538.11 EFA79996.1 - 0.059 13.3 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 Clostridial hydrophobic W Gtr1_RagA PF04670.12 EFA79997.1 - 3.5e-71 239.2 3.9 4.7e-71 238.8 3.9 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFA79997.1 - 1.1e-06 28.2 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA79997.1 - 1.9e-06 28.1 0.0 3.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA79997.1 - 3.5e-05 23.3 0.1 5.7e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA79997.1 - 0.00015 21.4 0.2 0.00021 20.9 0.2 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFA79997.1 - 0.00029 20.9 0.0 0.0015 18.6 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Stirrup PF09061.6 EFA79997.1 - 0.015 15.5 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Stirrup GST_N_2 PF13409.6 EFA79998.1 - 6.2e-21 74.5 0.0 1.6e-20 73.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA79998.1 - 2.5e-10 40.2 0.0 4.3e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA79998.1 - 8.7e-06 25.9 0.2 1.8e-05 24.8 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA79998.1 - 0.00058 20.0 0.0 0.00091 19.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA79998.1 - 0.0047 16.7 0.1 0.01 15.6 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA79998.1 - 0.017 15.5 0.1 0.13 12.7 0.1 2.4 2 1 0 2 2 2 0 Glutathione S-transferase, N-terminal domain IML1 PF12257.8 EFA79999.1 - 8.7e-51 172.7 0.0 1.8e-50 171.7 0.0 1.5 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EFA79999.1 - 3.7e-20 71.7 0.3 1.2e-19 70.2 0.3 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G_glu_transpept PF01019.21 EFA80000.1 - 1.3e-128 430.0 0.0 1.6e-121 406.6 0.0 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase PH PF00169.29 EFA80001.1 - 6.8e-15 55.5 0.5 1.1e-14 54.8 0.5 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA80001.1 - 0.0045 17.4 8.2 0.0049 17.3 3.0 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 EFA80001.1 - 0.0068 16.8 0.3 0.031 14.6 0.3 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFA80001.1 - 0.01 16.1 0.1 0.02 15.1 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Drf_FH1 PF06346.12 EFA80001.1 - 0.034 13.9 2.3 0.051 13.3 2.3 1.2 1 0 0 1 1 1 0 Formin Homology Region 1 PH_17 PF18012.1 EFA80001.1 - 0.036 13.8 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 PH domain DUF5393 PF17371.2 EFA80001.1 - 0.79 7.8 4.9 1.1 7.3 4.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5393) 7TMR-DISM_7TM PF07695.11 EFA80002.1 - 3.5 7.5 20.0 0.11 12.4 11.0 2.2 2 0 0 2 2 2 0 7TM diverse intracellular signalling CWC25 PF12542.8 EFA80004.1 - 1.1e-13 51.9 2.8 1.1e-13 51.9 2.8 5.2 2 1 0 2 2 2 1 Pre-mRNA splicing factor CDC45 PF02724.14 EFA80007.1 - 0.81 7.9 36.2 0.93 7.7 36.2 1.2 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 EFA80007.1 - 0.9 6.6 36.0 0.88 6.6 36.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Dapper PF15268.6 EFA80007.1 - 4.9 5.9 44.6 5.8 5.6 44.6 1.2 1 0 0 1 1 1 0 Dapper CLIP_SPH_mas PF18398.1 EFA80008.1 - 0.046 14.1 5.6 9.6 6.7 0.3 3.1 2 1 1 3 3 3 0 Clip-domain serine protease homolog masquerade DUF2085 PF09858.9 EFA80008.1 - 0.13 12.7 6.2 2.2 8.8 4.8 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2085) DNA_RNApol_7kD PF03604.13 EFA80010.1 - 6.4e-17 60.9 7.2 7.7e-17 60.7 7.2 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 EFA80010.1 - 0.028 14.5 2.6 0.034 14.2 2.6 1.1 1 0 0 1 1 1 0 Double zinc ribbon MCM_OB PF17207.3 EFA80010.1 - 0.055 13.3 1.9 0.059 13.2 1.9 1.1 1 0 0 1 1 1 0 MCM OB domain zinc_ribbon_13 PF09855.9 EFA80010.1 - 0.11 12.7 0.3 0.11 12.7 0.3 1.8 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) RCC1 PF00415.18 EFA80011.1 - 2.5e-94 309.8 15.3 4.2e-16 59.3 0.0 9.0 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA80011.1 - 1.1e-39 133.4 38.2 6.9e-08 32.1 1.5 7.9 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Clathrin PF00637.20 EFA80011.1 - 0.00013 21.9 12.5 0.019 14.9 1.0 3.0 3 0 0 3 3 3 2 Region in Clathrin and VPS Trypsin_2 PF13365.6 EFA80013.1 - 0.00034 21.5 0.0 0.00067 20.6 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_C3 PF00548.20 EFA80013.1 - 0.021 14.8 0.2 0.037 14.0 0.2 1.4 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) Trypsin_2 PF13365.6 EFA80014.1 - 4.8e-07 30.8 0.0 1.1e-06 29.6 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80014.1 - 0.1 12.4 0.0 10 5.9 0.0 2.4 1 1 0 2 2 2 0 Trypsin Trypsin_2 PF13365.6 EFA80015.1 - 3.9e-08 34.3 0.0 8.1e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80015.1 - 0.0042 16.9 0.0 0.025 14.4 0.0 2.0 1 1 0 1 1 1 1 Trypsin Peptidase_C3 PF00548.20 EFA80015.1 - 0.037 13.9 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) vWF_A PF12450.8 EFA80015.1 - 0.06 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor Trypsin_2 PF13365.6 EFA80016.1 - 3.1e-13 50.9 0.0 3.2e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80016.1 - 0.00082 19.2 0.0 0.96 9.2 0.0 2.9 2 1 0 2 2 2 2 Trypsin Glycoamylase PF10091.9 EFA80016.1 - 0.014 15.0 0.2 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Putative glucoamylase Trypsin_2 PF13365.6 EFA80018.1 - 1.2e-08 35.9 0.0 2.4e-08 35.0 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80018.1 - 2e-06 27.8 0.2 1.9e-05 24.6 0.2 2.3 1 1 0 1 1 1 1 Trypsin HMD PF03201.16 EFA80018.1 - 0.038 14.2 0.6 0.079 13.2 0.6 1.5 1 0 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Mod_r PF07200.13 EFA80018.1 - 0.18 11.9 10.1 0.83 9.7 9.7 2.0 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF3135 PF11333.8 EFA80018.1 - 0.56 10.5 10.0 1.4 9.2 10.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) Trypsin_2 PF13365.6 EFA80019.1 - 2.1e-10 41.7 0.0 6.4e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80019.1 - 7.3e-06 26.0 0.0 0.0041 17.0 0.0 2.2 1 1 0 1 1 1 1 Trypsin Peptidase_C3 PF00548.20 EFA80019.1 - 0.047 13.6 1.2 0.077 12.9 0.3 1.8 2 0 0 2 2 2 0 3C cysteine protease (picornain 3C) Glycoamylase PF10091.9 EFA80019.1 - 0.048 13.2 0.1 0.073 12.6 0.1 1.3 1 0 0 1 1 1 0 Putative glucoamylase Trypsin_2 PF13365.6 EFA80020.1 - 2.5e-05 25.2 0.0 4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin_2 PF13365.6 EFA80021.1 - 5.2e-19 69.6 0.0 2.3e-08 35.1 0.0 2.8 2 2 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80021.1 - 3.6e-09 36.8 0.1 0.0026 17.6 0.0 3.7 4 0 0 4 4 4 2 Trypsin Peptidase_C3 PF00548.20 EFA80021.1 - 7.4e-05 22.7 0.2 0.31 11.0 0.0 2.9 2 0 0 2 2 2 2 3C cysteine protease (picornain 3C) Glycoamylase PF10091.9 EFA80021.1 - 0.001 18.7 0.6 1.3 8.5 0.1 2.4 2 0 0 2 2 2 2 Putative glucoamylase DUF5598 PF18127.1 EFA80021.1 - 0.024 15.1 0.1 4.5 7.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5598) PG_binding_1 PF01471.18 EFA80021.1 - 0.066 13.4 0.0 22 5.3 0.0 2.7 2 0 0 2 2 2 0 Putative peptidoglycan binding domain DUF3754 PF12576.8 EFA80021.1 - 0.096 12.6 0.2 9.4 6.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) KRTDAP PF15200.6 EFA80021.1 - 0.11 12.3 0.1 2 8.3 0.0 2.5 2 0 0 2 2 2 0 Keratinocyte differentiation-associated PLD_C PF12357.8 EFA80021.1 - 4.8 7.2 5.0 27 4.7 0.0 3.3 5 0 0 5 5 5 0 Phospholipase D C terminal Trypsin_2 PF13365.6 EFA80022.1 - 1.5e-09 38.9 0.0 2.4e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80022.1 - 0.011 15.6 0.4 0.065 13.0 0.4 2.1 1 1 0 1 1 1 0 Trypsin Trypsin_2 PF13365.6 EFA80023.1 - 2.8e-17 64.0 0.0 4.3e-07 30.9 0.0 2.7 2 1 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80023.1 - 0.00033 20.5 0.0 1.6 8.5 0.0 3.2 3 1 0 3 3 3 2 Trypsin Peptidase_C3 PF00548.20 EFA80023.1 - 0.0052 16.7 5.2 0.73 9.7 0.2 2.8 3 0 0 3 3 3 2 3C cysteine protease (picornain 3C) Glycoamylase PF10091.9 EFA80023.1 - 0.0081 15.8 1.6 2.1 7.9 0.2 2.6 3 0 0 3 3 3 2 Putative glucoamylase FAM60A PF15396.6 EFA80023.1 - 0.043 13.8 0.1 3 7.8 0.1 2.4 2 0 0 2 2 2 0 Protein Family FAM60A YrbL-PhoP_reg PF10707.9 EFA80023.1 - 0.13 11.8 0.2 0.13 11.8 0.2 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Sec34 PF04136.15 EFA80023.1 - 0.39 10.6 8.9 0.37 10.7 0.2 3.7 4 0 0 4 4 4 0 Sec34-like family Trypsin_2 PF13365.6 EFA80024.1 - 1.6e-08 35.6 0.0 4.1e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA80024.1 - 0.0013 18.6 0.7 0.12 12.1 0.1 2.5 2 1 0 2 2 2 2 Trypsin Peptidase_C3 PF00548.20 EFA80024.1 - 0.0039 17.2 1.0 0.0094 15.9 0.1 2.1 2 0 0 2 2 2 1 3C cysteine protease (picornain 3C) Phage_head_chap PF11113.8 EFA80024.1 - 0.072 13.2 0.9 0.24 11.5 0.4 2.2 2 0 0 2 2 2 0 Head assembly gene product TNRC6-PABC_bdg PF16608.5 EFA80025.1 - 0.17 11.5 0.4 0.26 11.0 0.4 1.2 1 0 0 1 1 1 0 TNRC6-PABC binding domain Spc7 PF08317.11 EFA80027.1 - 1.8e-13 50.0 12.2 1.8e-13 50.0 12.2 4.7 4 1 1 5 5 5 3 Spc7 kinetochore protein Knl1_RWD_C PF18210.1 EFA80027.1 - 0.0068 16.9 0.0 0.03 14.8 0.0 2.1 1 0 0 1 1 1 1 Knl1 RWD C-terminal domain Spc7_N PF15402.6 EFA80027.1 - 2.8 6.1 59.8 0.45 8.7 6.8 4.0 1 1 3 4 4 4 0 N-terminus of kinetochore NMS complex subunit Spc7 LRR_4 PF12799.7 EFA80028.1 - 0.00056 20.2 2.0 0.00056 20.2 2.0 7.9 3 2 4 8 8 8 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA80028.1 - 1 10.2 24.2 17 6.5 4.5 6.7 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_9 PF14580.6 EFA80028.1 - 3.6 7.0 9.7 0.11 12.0 1.6 2.6 3 1 1 4 4 4 0 Leucine-rich repeat PHD PF00628.29 EFA80029.1 - 3.2e-11 42.9 13.1 2e-09 37.2 8.0 2.5 1 1 1 2 2 2 2 PHD-finger FHA PF00498.26 EFA80029.1 - 4.9e-10 39.6 0.5 1.6e-09 38.0 0.5 2.0 1 0 0 1 1 1 1 FHA domain PHD_2 PF13831.6 EFA80029.1 - 8.4e-05 22.1 1.8 0.00021 20.8 1.8 1.7 1 0 0 1 1 1 1 PHD-finger Ribosomal_S11 PF00411.19 EFA80029.1 - 0.0031 17.9 0.8 0.0063 16.9 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S11 zf-HC5HC2H PF13771.6 EFA80029.1 - 0.0064 16.7 7.6 0.11 12.8 1.0 3.2 2 0 0 2 2 2 2 PHD-like zinc-binding domain Aminoglyc_resit PF10706.9 EFA80029.1 - 0.17 11.6 0.0 0.46 10.2 0.0 1.6 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase zf-HC5HC2H_2 PF13832.6 EFA80029.1 - 0.27 11.4 6.5 1.8 8.7 0.8 2.9 2 0 0 2 2 2 0 PHD-zinc-finger like domain TPR_2 PF07719.17 EFA80030.1 - 4.7e-07 29.4 1.2 0.13 12.4 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA80030.1 - 0.00012 22.5 2.1 1.1 10.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA80030.1 - 0.00034 21.2 0.0 0.0048 17.6 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA80030.1 - 0.00077 19.5 0.5 0.12 12.7 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA80030.1 - 0.0021 18.6 0.4 0.58 10.7 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA80030.1 - 0.0021 17.8 0.8 3.9 7.5 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA80030.1 - 0.013 15.8 2.9 15 6.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5588 PF17826.1 EFA80030.1 - 0.02 13.8 0.3 0.1 11.5 0.3 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5588) TPR_9 PF13371.6 EFA80030.1 - 0.024 14.8 0.0 0.073 13.2 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA80030.1 - 0.11 12.5 0.9 1.1e+02 3.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ABC_tran PF00005.27 EFA80031.1 - 9.8e-08 32.6 0.0 1.3e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA80031.1 - 6.9e-06 26.1 0.0 7.6e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF1184 PF06683.11 EFA80031.1 - 0.13 11.7 0.1 0.23 10.9 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1184) Ank_5 PF13857.6 EFA80032.1 - 0.0058 16.9 0.4 0.96 9.8 0.0 3.3 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80032.1 - 0.0085 16.5 0.6 3.7 8.4 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 EFA80032.1 - 0.033 14.8 0.1 0.12 12.9 0.1 1.9 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) adh_short PF00106.25 EFA80033.1 - 6e-48 162.9 0.0 8.1e-48 162.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA80033.1 - 1.1e-34 120.0 0.0 1.5e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA80033.1 - 2e-13 50.6 0.0 2.9e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA80033.1 - 3.6e-05 23.3 0.3 0.00036 20.1 0.2 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA80033.1 - 9.9e-05 22.3 0.1 0.00017 21.5 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFA80033.1 - 0.00025 20.3 0.0 0.0004 19.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain DUF1776 PF08643.10 EFA80033.1 - 0.00029 20.3 0.0 0.00044 19.7 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFA80033.1 - 0.016 14.6 0.1 0.079 12.3 0.1 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ABC_tran PF00005.27 EFA80034.1 - 1.4e-25 90.4 0.0 3.4e-25 89.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA80034.1 - 1.8e-21 76.7 41.8 2.9e-21 76.0 41.8 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA80034.1 - 6.8e-13 49.1 3.9 6.4e-09 36.1 0.3 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFA80034.1 - 0.00029 20.8 0.0 0.00076 19.5 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain SMC_N PF02463.19 EFA80034.1 - 0.002 17.6 0.5 0.094 12.1 0.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFA80034.1 - 0.008 15.9 0.0 0.008 15.9 0.0 3.6 2 1 1 4 4 4 2 AAA ATPase domain DUF4162 PF13732.6 EFA80034.1 - 0.039 14.7 0.0 0.096 13.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) ABC2_membrane PF01061.24 EFA80034.1 - 0.1 12.0 41.8 0.12 11.7 26.4 3.1 2 1 1 3 3 3 0 ABC-2 type transporter Phage_holin_6_1 PF09682.10 EFA80034.1 - 0.4 11.1 4.1 15 6.0 0.4 3.5 3 0 0 3 3 3 0 Bacteriophage holin of superfamily 6 (Holin_LLH) ABC_tran PF00005.27 EFA80035.1 - 1.2e-27 97.1 0.0 2.3e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA80035.1 - 7.7e-10 38.4 35.2 7.7e-10 38.4 35.2 2.0 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA80035.1 - 1.3e-07 31.8 0.6 3.4e-06 27.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA80035.1 - 0.0011 18.9 0.1 0.0026 17.7 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 EFA80035.1 - 0.012 15.4 0.5 1.2 8.8 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain AAA_23 PF13476.6 EFA80035.1 - 0.017 15.7 1.4 0.039 14.4 0.3 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFA80035.1 - 0.036 13.3 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin SMC_N PF02463.19 EFA80035.1 - 0.15 11.5 0.8 14 5.0 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFA80035.1 - 0.19 11.8 0.8 0.54 10.4 0.5 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Lambda_Bor PF06291.11 EFA80036.1 - 0.12 12.4 0.1 0.23 11.5 0.0 1.5 2 0 0 2 2 2 0 Bor protein ABC_tran PF00005.27 EFA80037.1 - 1.6e-25 90.2 0.0 3.5e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA80037.1 - 4.3e-22 78.7 32.6 6.2e-22 78.2 32.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA80037.1 - 6.2e-14 52.5 2.2 4.1e-09 36.7 0.1 2.6 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFA80037.1 - 0.00031 20.7 0.0 0.00087 19.3 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain SMC_N PF02463.19 EFA80037.1 - 0.00041 19.9 0.0 0.04 13.3 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFA80037.1 - 0.0019 18.0 0.0 0.0019 18.0 0.0 3.8 2 1 1 4 4 4 2 AAA ATPase domain ABC2_membrane_2 PF12679.7 EFA80037.1 - 0.003 16.9 18.5 0.003 16.9 18.5 2.1 1 1 1 2 2 2 1 ABC-2 family transporter protein FliP PF00813.20 EFA80037.1 - 0.045 13.6 9.5 0.096 12.6 9.5 1.6 1 0 0 1 1 1 0 FliP family DUF4162 PF13732.6 EFA80037.1 - 0.066 13.9 0.7 0.14 12.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) ABC2_membrane PF01061.24 EFA80037.1 - 0.51 9.7 30.8 0.045 13.2 25.6 1.8 1 1 0 2 2 2 0 ABC-2 type transporter ABC_tran PF00005.27 EFA80038.1 - 4.3e-28 98.5 0.0 8.9e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA80038.1 - 4.9e-07 29.9 4.0 4.8e-06 26.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA80038.1 - 0.0036 17.2 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 EFA80038.1 - 0.011 16.2 0.5 0.049 14.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 EFA80038.1 - 0.012 14.8 28.7 0.18 10.8 25.0 3.3 2 1 0 2 2 2 0 ABC-2 family transporter protein Peptidase_M56 PF05569.11 EFA80038.1 - 0.056 12.6 3.4 0.1 11.8 3.4 1.4 1 0 0 1 1 1 0 BlaR1 peptidase M56 Zeta_toxin PF06414.12 EFA80038.1 - 0.075 12.3 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin ABC2_membrane_2 PF12679.7 EFA80038.1 - 0.37 10.0 8.6 0.71 9.1 8.2 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein Kinesin PF00225.23 EFA80039.1 - 3.7e-109 364.7 0.4 3.7e-109 364.7 0.4 2.6 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFA80039.1 - 1.8e-32 112.3 0.0 1.8e-32 112.3 0.0 3.6 2 1 1 3 3 3 1 Microtubule binding Img2 PF05046.14 EFA80039.1 - 0.4 11.0 2.1 2.6 8.4 2.1 2.4 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) GAS PF13851.6 EFA80039.1 - 2.8 7.2 70.2 0.038 13.4 18.8 3.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding TIG PF01833.24 EFA80040.1 - 0.00045 20.2 0.1 0.00045 20.2 0.1 4.2 3 2 1 4 4 4 2 IPT/TIG domain EB PF01683.18 EFA80040.1 - 0.00097 19.4 5.1 0.0024 18.1 5.1 1.6 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 EFA80040.1 - 0.0036 17.6 19.2 0.0079 16.5 19.2 1.6 1 0 0 1 1 1 1 EGF-like domain Insulin_TMD PF17870.1 EFA80040.1 - 0.12 12.5 2.0 0.26 11.4 2.0 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment hEGF PF12661.7 EFA80040.1 - 0.15 12.8 9.4 0.41 11.4 9.4 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFA80040.1 - 1.5 8.9 9.7 3.5 7.8 9.7 1.6 1 0 0 1 1 1 0 Tenascin EGF domain OTU PF02338.19 EFA80042.1 - 2.9e-14 53.6 0.0 8.2e-14 52.2 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease zf-HIT PF04438.16 EFA80043.1 - 2.2e-06 27.4 10.3 3.4e-06 26.8 10.3 1.2 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 EFA80043.1 - 0.0022 18.0 9.3 0.0037 17.3 9.3 1.3 1 0 0 1 1 1 1 MYND finger Lactamase_B_2 PF12706.7 EFA80044.1 - 6.6e-15 55.2 0.0 6e-13 48.8 0.1 2.4 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 EFA80044.1 - 6.2e-12 45.0 0.0 1.4e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 tRNase Z endonuclease zf-B_box PF00643.24 EFA80045.1 - 1.4e-06 28.4 8.4 1.4e-06 28.4 8.4 2.2 2 0 0 2 2 2 1 B-box zinc finger Synaptobrevin PF00957.21 EFA80046.1 - 2.2e-28 97.9 3.8 3.2e-28 97.3 3.8 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFA80046.1 - 4.7e-25 87.4 0.1 7.9e-25 86.7 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain SET PF00856.28 EFA80047.1 - 3.2e-12 47.2 0.0 6.1e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 SET domain FtsJ PF01728.19 EFA80047.1 - 0.042 13.9 0.0 0.089 12.9 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase RhoGEF PF00621.20 EFA80048.1 - 4.4e-38 131.4 0.6 4.4e-38 131.4 0.6 1.8 2 0 0 2 2 2 1 RhoGEF domain zf-ribbon_3 PF13248.6 EFA80048.1 - 0.00061 19.1 6.4 0.0017 17.7 6.4 1.8 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EFA80048.1 - 0.0068 16.1 8.3 0.016 14.9 8.3 1.7 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EFA80048.1 - 0.31 11.1 9.1 0.04 14.0 4.1 2.0 2 0 0 2 2 2 0 Double zinc ribbon NOB1_Zn_bind PF08772.11 EFA80048.1 - 0.67 10.2 3.9 1.7 8.8 3.9 1.7 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like EGF_2 PF07974.13 EFA80049.1 - 2.7e-05 24.4 13.3 5.6e-05 23.4 13.3 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA80049.1 - 0.0086 16.1 3.5 0.028 14.4 3.5 1.9 1 0 0 1 1 1 1 Tenascin EGF domain hEGF PF12661.7 EFA80049.1 - 0.058 14.1 7.1 0.21 12.3 7.1 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 EFA80049.1 - 5.3 7.4 17.3 0.21 11.9 11.2 1.9 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 EFA80050.1 - 5.7e-06 26.6 11.4 1.5e-05 25.3 11.4 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA80050.1 - 0.02 14.9 4.0 0.05 13.7 4.0 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 EFA80050.1 - 0.08 13.3 11.1 0.21 11.9 11.1 1.8 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA80050.1 - 0.086 13.5 7.1 0.23 12.1 7.1 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.13 EFA80051.1 - 9.3e-09 35.5 31.9 0.00045 20.5 11.9 2.7 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EFA80051.1 - 0.0025 18.4 21.7 0.11 13.2 7.5 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF Romo1 PF10247.9 EFA80051.1 - 0.025 15.0 2.4 2.7 8.4 0.2 2.4 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Plasmod_Pvs28 PF06247.11 EFA80051.1 - 0.026 14.8 21.1 0.38 11.1 6.7 3.2 2 0 0 2 2 2 0 Pvs28 EGF domain EGF PF00008.27 EFA80051.1 - 0.086 13.2 27.9 0.79 10.1 9.8 2.7 2 0 0 2 2 2 0 EGF-like domain EphA2_TM PF14575.6 EFA80051.1 - 0.51 11.3 3.7 7 7.6 0.1 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain EGF_Tenascin PF18720.1 EFA80051.1 - 0.7 10.0 11.9 2.1 8.5 1.4 2.7 2 0 0 2 2 2 0 Tenascin EGF domain Laminin_EGF PF00053.24 EFA80051.1 - 9.9 6.4 24.3 15 5.9 8.4 2.7 2 0 0 2 2 2 0 Laminin EGF domain PRK PF00485.18 EFA80052.1 - 2e-25 89.7 0.8 1.2e-24 87.2 0.8 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CYTH PF01928.21 EFA80052.1 - 4.7e-07 29.9 0.0 7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 CYTH domain AAA_18 PF13238.6 EFA80052.1 - 0.00027 21.5 0.1 0.0032 18.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFA80052.1 - 0.00044 20.4 0.0 0.00076 19.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFA80052.1 - 0.00098 18.9 0.0 0.0023 17.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFA80052.1 - 0.0024 17.1 0.1 0.0059 15.8 0.1 1.6 1 0 0 1 1 1 1 NB-ARC domain EMG1 PF03587.14 EFA80052.1 - 0.01 15.5 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 0 EMG1/NEP1 methyltransferase AAA PF00004.29 EFA80052.1 - 0.02 15.4 0.1 0.4 11.1 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFA80052.1 - 0.02 14.8 0.1 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EFA80052.1 - 0.039 13.9 1.0 0.44 10.4 0.2 2.5 2 1 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 EFA80052.1 - 0.045 13.0 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EFA80052.1 - 0.052 13.5 0.0 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 NACHT domain DUF3730 PF12530.8 EFA80052.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) ABC_tran PF00005.27 EFA80052.1 - 0.078 13.5 0.0 0.25 11.9 0.0 1.9 2 0 0 2 2 2 0 ABC transporter dNK PF01712.19 EFA80052.1 - 0.08 12.8 0.1 1.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_16 PF13191.6 EFA80052.1 - 0.083 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SURNod19 PF07712.12 EFA80052.1 - 0.088 11.5 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Stress up-regulated Nod 19 Mg_chelatase PF01078.21 EFA80052.1 - 0.099 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA80052.1 - 0.11 12.5 0.0 0.31 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.14 EFA80052.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B zf-B_box PF00643.24 EFA80053.1 - 0.0027 17.8 12.2 0.0027 17.8 12.2 1.9 2 0 0 2 2 2 1 B-box zinc finger Endotoxin_N PF03945.14 EFA80054.1 - 1.5e-18 67.3 2.1 3.7e-18 66.1 2.1 1.7 1 1 0 1 1 1 1 delta endotoxin, N-terminal domain THOC7 PF05615.13 EFA80055.1 - 9e-21 74.5 8.4 9e-21 74.5 8.4 2.3 1 1 1 2 2 2 1 Tho complex subunit 7 V_ATPase_I PF01496.19 EFA80055.1 - 0.067 11.1 16.4 0.08 10.9 16.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF848 PF05852.11 EFA80055.1 - 1.4 9.0 19.4 0.52 10.4 3.4 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) PDGF_N PF04692.13 EFA80055.1 - 2.1 9.2 7.2 0.41 11.5 2.4 2.3 2 1 1 3 3 3 0 Platelet-derived growth factor, N terminal region DUF3496 PF12001.8 EFA80055.1 - 7.1 7.1 20.8 0.19 12.1 3.8 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) FH2 PF02181.23 EFA80057.1 - 3.2e-78 263.5 1.8 3.2e-78 263.5 1.8 3.0 3 1 0 3 3 3 1 Formin Homology 2 Domain DUF3361 PF11841.8 EFA80057.1 - 2.5e-07 30.8 0.0 9.6e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) DUF3450 PF11932.8 EFA80057.1 - 0.27 10.5 12.8 1.1 8.5 5.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF2802 PF10975.8 EFA80057.1 - 1.7 8.8 6.9 8.7 6.5 0.7 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2802) NPV_P10 PF05531.12 EFA80057.1 - 2.5 8.6 9.9 4.8 7.7 0.5 4.6 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 EFA80057.1 - 4.4 6.4 13.7 11 5.1 4.9 3.2 3 0 0 3 3 3 0 TMPIT-like protein Mito_carr PF00153.27 EFA80058.1 - 6.1e-28 96.6 5.2 2.3e-22 78.7 1.1 3.1 2 1 0 2 2 2 2 Mitochondrial carrier protein HMD PF03201.16 EFA80058.1 - 0.092 13.0 0.0 3.8 7.8 0.0 2.3 1 1 1 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Ank_2 PF12796.7 EFA80060.1 - 2.6e-35 120.9 9.1 1.3e-07 32.1 0.3 6.6 4 2 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80060.1 - 4.3e-32 110.1 13.4 8.3e-05 23.1 0.1 11.1 6 4 7 13 13 13 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA80060.1 - 1.1e-28 98.9 11.2 0.014 15.7 0.1 12.7 4 2 9 13 13 13 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80060.1 - 4.2e-20 69.7 5.8 0.43 11.3 0.0 13.4 13 2 2 15 15 15 4 Ankyrin repeat DUF3447 PF11929.8 EFA80060.1 - 3.6e-06 26.8 10.4 0.01 15.8 0.1 5.5 3 2 2 6 6 6 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA80060.1 - 0.0084 16.5 5.2 59 4.4 0.4 6.6 5 2 1 6 6 6 0 Ankyrin repeat tRNA-synt_1e PF01406.19 EFA80061.1 - 4.1e-100 335.0 0.1 4.1e-100 335.0 0.1 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFA80061.1 - 4e-08 32.4 3.1 0.0025 16.6 0.1 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EFA80061.1 - 0.0019 18.7 1.0 0.0071 16.8 0.1 2.5 1 1 1 2 2 2 1 DALR domain Mucin PF01456.17 EFA80061.1 - 0.32 11.0 25.0 0.73 9.8 25.0 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Androgen_recep PF02166.16 EFA80061.1 - 4.6 6.0 7.9 9.8 4.9 7.9 1.5 1 0 0 1 1 1 0 Androgen receptor Fer4 PF00037.27 EFA80063.1 - 1.6e-14 53.0 17.9 7.6e-09 35.0 5.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EFA80063.1 - 4.5e-13 49.6 10.8 6.5e-13 49.0 10.8 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EFA80063.1 - 2.6e-11 44.3 6.6 7.9e-06 26.7 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EFA80063.1 - 3.5e-10 39.8 22.4 5.8e-07 29.5 13.2 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EFA80063.1 - 5.7e-10 39.2 4.0 0.00014 22.0 0.4 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFA80063.1 - 3.7e-09 36.6 10.7 6e-09 35.9 10.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFA80063.1 - 1.7e-07 31.6 19.6 0.00015 22.1 12.2 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFA80063.1 - 2.4e-07 30.5 18.2 0.00029 20.8 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EFA80063.1 - 8.9e-07 28.6 12.4 0.0021 18.0 2.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EFA80063.1 - 1e-05 25.7 11.2 0.00025 21.3 2.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EFA80063.1 - 0.00029 21.3 12.6 0.027 15.0 13.8 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 EFA80063.1 - 0.0067 16.9 15.0 0.34 11.5 2.9 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I c-SKI_SMAD_bind PF08782.10 EFA80063.1 - 0.0085 16.3 6.1 0.39 11.0 0.3 2.2 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_18 PF13746.6 EFA80063.1 - 0.011 16.0 8.6 0.62 10.3 1.1 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EFA80063.1 - 0.034 15.1 16.5 0.072 14.1 4.3 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 EFA80063.1 - 0.23 11.6 6.0 1.4 9.1 0.7 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 EFA80063.1 - 0.31 11.9 11.7 1.4 9.9 1.9 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Cullin PF00888.22 EFA80064.1 - 8.5e-31 107.2 11.0 8.5e-31 107.2 11.0 2.0 2 1 0 2 2 2 1 Cullin family ANAPC2 PF08672.11 EFA80064.1 - 5.3e-21 74.9 4.0 3e-20 72.5 0.3 3.5 3 0 0 3 3 3 1 Anaphase promoting complex (APC) subunit 2 Nore1-SARAH PF16517.5 EFA80064.1 - 0.0068 16.3 0.5 0.025 14.5 0.5 2.0 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain PCI PF01399.27 EFA80064.1 - 0.083 13.4 2.2 1.3 9.5 0.2 3.5 3 0 0 3 3 3 0 PCI domain FeoC PF09012.10 EFA80064.1 - 0.12 12.4 0.0 0.47 10.6 0.0 2.0 1 0 0 1 1 1 0 FeoC like transcriptional regulator EamA PF00892.20 EFA80065.1 - 2.9e-49 166.7 66.8 8.8e-18 64.8 9.5 4.0 3 1 1 4 4 4 4 EamA-like transporter family EamA PF00892.20 EFA80066.1 - 2.4e-26 92.6 35.5 3.6e-16 59.6 11.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF2678 PF10856.8 EFA80066.1 - 1.4 8.8 12.5 0.36 10.8 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) FNIP PF05725.12 EFA80067.1 - 2e-21 75.9 7.1 6.1e-06 26.3 0.0 8.6 7 2 0 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA80067.1 - 0.079 12.6 0.2 0.18 11.4 0.2 1.5 1 0 0 1 1 1 0 F-box MFMR_assoc PF16596.5 EFA80068.1 - 1.9 8.9 9.2 3.4 8.1 9.2 1.4 1 0 0 1 1 1 0 Disordered region downstream of MFMR FNIP PF05725.12 EFA80069.1 - 1.2e-17 63.8 35.9 4.7e-06 26.7 0.4 9.2 6 1 4 10 10 10 6 FNIP Repeat LRR_8 PF13855.6 EFA80069.1 - 0.0072 16.1 1.9 2.7 7.8 0.1 3.6 2 0 0 2 2 2 2 Leucine rich repeat F-box_5 PF18511.1 EFA80069.1 - 0.077 12.6 0.2 0.48 10.0 0.0 2.2 2 0 0 2 2 2 0 F-box LRR_4 PF12799.7 EFA80069.1 - 0.14 12.6 14.1 1.5 9.3 0.4 5.9 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) Rhodanese PF00581.20 EFA80070.1 - 1e-06 29.2 0.0 1.4e-06 28.8 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Ank_4 PF13637.6 EFA80071.1 - 4.2e-08 33.6 0.3 0.0052 17.3 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80071.1 - 8.9e-08 32.6 0.7 1e-05 26.0 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80071.1 - 5.5e-07 29.7 0.0 0.0053 17.0 0.0 3.1 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80071.1 - 0.024 15.2 0.1 11 7.0 0.0 3.4 4 0 0 4 4 4 0 Ankyrin repeat Helicase_RecD PF05127.14 EFA80071.1 - 0.045 13.6 0.0 0.066 13.1 0.0 1.2 1 0 0 1 1 1 0 Helicase RRM_1 PF00076.22 EFA80073.1 - 1.3e-11 44.2 0.1 8.7e-07 28.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) C2 PF00168.30 EFA80074.1 - 5.6e-10 39.4 0.0 8.1e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 C2 domain FNIP PF05725.12 EFA80075.1 - 1.1e-06 28.7 22.3 0.055 13.7 0.0 7.6 6 2 1 7 7 7 4 FNIP Repeat F-box_5 PF18511.1 EFA80075.1 - 0.041 13.5 0.0 0.094 12.3 0.0 1.6 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 EFA80075.1 - 0.076 12.9 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 F-box-like LRR_8 PF13855.6 EFA80075.1 - 1.8 8.4 7.8 0.44 10.3 1.0 3.5 4 1 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.7 EFA80075.1 - 4.8 7.7 14.0 17 6.0 0.1 5.3 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) Cullin PF00888.22 EFA80076.1 - 3.6e-08 32.5 0.1 3.9e-08 32.4 0.1 1.0 1 0 0 1 1 1 1 Cullin family DUF3760 PF12586.8 EFA80076.1 - 0.031 14.5 0.1 0.089 13.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) Mating_N PF12731.7 EFA80076.1 - 0.044 13.9 0.2 0.07 13.2 0.2 1.4 1 0 0 1 1 1 0 Mating-type protein beta 1 SurE PF01975.17 EFA80078.1 - 0.073 12.8 0.4 0.094 12.5 0.4 1.4 1 0 0 1 1 1 0 Survival protein SurE Ribosomal_S27e PF01667.17 EFA80078.1 - 1.3 8.8 7.3 1.6 8.5 2.7 2.4 2 0 0 2 2 2 0 Ribosomal protein S27 FNIP PF05725.12 EFA80079.1 - 1.4e-05 25.2 2.3 0.0019 18.4 0.3 9.2 8 3 3 11 11 11 3 FNIP Repeat F-box_5 PF18511.1 EFA80079.1 - 0.0038 16.7 0.1 0.0074 15.8 0.1 1.4 1 0 0 1 1 1 1 F-box LRR_6 PF13516.6 EFA80079.1 - 1.4 9.2 4.0 1.5 9.1 0.1 3.2 4 0 0 4 4 4 0 Leucine Rich repeat F-box_5 PF18511.1 EFA80080.1 - 2.3e-05 23.9 0.9 4.5e-05 22.9 0.9 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80080.1 - 0.0012 18.7 1.7 0.0039 17.1 1.7 1.9 1 0 0 1 1 1 1 F-box-like FNIP PF05725.12 EFA80080.1 - 0.0058 16.8 36.6 0.12 12.5 0.4 8.9 8 2 1 9 9 9 5 FNIP Repeat MPP6 PF10175.9 EFA80081.1 - 2.8e-12 47.3 18.4 2.8e-12 47.3 18.4 2.2 1 1 1 2 2 1 1 M-phase phosphoprotein 6 Utp14 PF04615.13 EFA80081.1 - 0.11 11.0 29.1 0.13 10.9 29.1 1.0 1 0 0 1 1 1 0 Utp14 protein Neur_chan_memb PF02932.16 EFA80081.1 - 0.12 12.5 11.8 0.15 12.1 11.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TT_ORF1 PF02956.14 EFA80081.1 - 0.23 10.1 17.3 0.28 9.8 17.3 1.1 1 0 0 1 1 1 0 TT viral orf 1 DUF4175 PF13779.6 EFA80081.1 - 1.5 6.6 18.1 1.7 6.5 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CLN3 PF02487.17 EFA80081.1 - 1.8 7.5 8.8 2.3 7.1 8.8 1.3 1 0 0 1 1 1 0 CLN3 protein Menin PF05053.13 EFA80081.1 - 2.3 6.5 20.1 3.1 6.1 20.1 1.2 1 0 0 1 1 1 0 Menin RPA_C PF08784.11 EFA80081.1 - 4.4 8.0 19.6 2.9 8.6 17.7 1.8 1 1 1 2 2 2 0 Replication protein A C terminal DUF3533 PF12051.8 EFA80081.1 - 5.5 5.8 6.9 6.9 5.5 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Cellulose_synt PF03552.14 EFA80081.1 - 6.1 5.2 7.5 7.4 4.9 7.5 1.1 1 0 0 1 1 1 0 Cellulose synthase SID-1_RNA_chan PF13965.6 EFA80081.1 - 10 4.4 8.8 10 4.4 8.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FNIP PF05725.12 EFA80082.1 - 0.00036 20.6 23.3 0.045 13.9 0.1 6.4 5 1 1 7 7 7 3 FNIP Repeat DUF3452 PF11934.8 EFA80082.1 - 0.0062 16.1 2.4 0.012 15.1 2.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) F-box_5 PF18511.1 EFA80082.1 - 0.017 14.7 0.5 0.043 13.4 0.5 1.6 1 0 0 1 1 1 0 F-box Gly_kinase PF02595.15 EFA80083.1 - 5.3e-105 351.4 2.4 6.2e-105 351.2 2.4 1.0 1 0 0 1 1 1 1 Glycerate kinase family Cas_APE2256 PF09651.10 EFA80083.1 - 0.015 15.2 0.1 0.065 13.1 0.0 2.0 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_APE2256) DUF739 PF05339.11 EFA80083.1 - 0.017 15.2 0.0 5.2 7.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF739) RRM_1 PF00076.22 EFA80084.1 - 4.7e-18 64.8 0.0 5.3e-18 64.6 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA80084.1 - 0.019 15.1 0.0 0.024 14.7 0.0 1.3 1 1 0 1 1 1 0 RNA recognition motif Peptidase_C1_2 PF03051.15 EFA80084.1 - 0.03 13.1 0.0 0.033 13.0 0.0 1.0 1 0 0 1 1 1 0 Peptidase C1-like family GST_N_2 PF13409.6 EFA80086.1 - 1.5e-13 50.8 0.0 3.8e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA80086.1 - 9.2e-13 48.4 0.0 2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFA80086.1 - 9.1e-11 42.0 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA80086.1 - 2.6e-09 37.2 0.0 5.7e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA80086.1 - 7.2e-09 35.7 0.0 1.5e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA80086.1 - 0.0021 18.1 0.0 0.0047 16.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EFA80086.1 - 0.024 14.8 0.0 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 Glutaredoxin Rav1p_C PF12234.8 EFA80088.1 - 5.2e-88 296.1 0.9 1.4e-87 294.6 0.6 1.9 2 0 0 2 2 2 1 RAVE protein 1 C terminal WD40 PF00400.32 EFA80088.1 - 2.6e-17 62.8 20.4 0.024 15.5 0.1 10.1 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80088.1 - 0.00059 20.1 0.0 2.9 8.3 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain FNIP PF05725.12 EFA80089.1 - 2.7e-08 33.9 29.9 0.011 15.9 0.0 7.9 7 2 1 8 8 8 4 FNIP Repeat LRR_4 PF12799.7 EFA80089.1 - 1e-05 25.8 8.2 0.0032 17.9 0.3 5.3 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA80089.1 - 0.0073 16.0 0.4 0.32 10.8 0.1 3.6 2 0 0 2 2 2 1 Leucine rich repeat F-box-like PF12937.7 EFA80089.1 - 0.011 15.6 0.4 0.029 14.3 0.4 1.8 1 0 0 1 1 1 0 F-box-like Synapsin_N PF10581.9 EFA80089.1 - 0.044 13.7 1.5 0.12 12.4 1.5 1.7 1 0 0 1 1 1 0 Synapsin N-terminal F-box_5 PF18511.1 EFA80089.1 - 0.049 13.2 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 F-box Pneumo_M2 PF07380.11 EFA80089.1 - 0.5 10.7 7.6 5.4 7.4 0.2 3.7 2 2 1 3 3 3 0 Pneumovirus M2 protein Glyco_hydro_35 PF01301.19 EFA80090.1 - 5.2e-104 348.3 6.2 7.3e-104 347.8 6.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 GHD PF17834.1 EFA80090.1 - 0.00014 21.8 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 Beta-sandwich domain in beta galactosidase Glyco_hydro_42 PF02449.15 EFA80090.1 - 0.00084 18.8 7.0 0.00084 18.8 7.0 2.0 1 1 1 2 2 2 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 EFA80090.1 - 0.21 12.2 5.3 0.93 10.1 0.1 3.4 3 0 0 3 3 3 0 Beta-galactosidase jelly roll domain Pkinase PF00069.25 EFA80091.1 - 1.1e-06 28.2 5.3 1e-05 25.1 3.3 2.5 2 1 1 3 3 3 1 Protein kinase domain TFIIA PF03153.13 EFA80091.1 - 0.017 15.2 19.2 0.021 14.9 19.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAP1 PF08601.10 EFA80091.1 - 0.67 9.6 24.8 0.88 9.2 24.8 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Macoilin PF09726.9 EFA80091.1 - 2.8 6.4 18.3 3.3 6.2 18.3 1.1 1 0 0 1 1 1 0 Macoilin family PNISR PF15996.5 EFA80091.1 - 6.2 7.0 9.2 8.7 6.6 9.2 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Oxysterol_BP PF01237.18 EFA80092.1 - 2.8e-58 197.6 0.5 4.5e-58 196.9 0.5 1.3 1 1 0 1 1 1 1 Oxysterol-binding protein Peptidase_M41 PF01434.18 EFA80093.1 - 7.3e-65 218.4 0.2 1.7e-64 217.2 0.2 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFA80093.1 - 6e-43 146.4 0.0 3.6e-42 143.9 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA80093.1 - 3.6e-11 42.7 0.1 1.1e-10 41.1 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFA80093.1 - 0.00014 21.9 0.0 0.0014 18.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Borrelia_P83 PF05262.11 EFA80093.1 - 0.00032 19.3 20.2 0.00064 18.3 20.2 1.5 1 0 0 1 1 1 1 Borrelia P83/100 protein FtsH_ext PF06480.15 EFA80093.1 - 0.0049 17.2 0.3 0.0049 17.2 0.3 3.1 2 1 0 2 2 2 1 FtsH Extracellular AAA_22 PF13401.6 EFA80093.1 - 0.0051 17.1 0.1 1 9.6 0.1 2.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFA80093.1 - 0.014 15.5 0.2 0.077 13.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EFA80093.1 - 0.028 14.2 0.1 0.095 12.4 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFA80093.1 - 0.035 14.5 0.2 0.58 10.5 0.1 2.6 1 1 1 2 2 2 0 AAA ATPase domain ATG22 PF11700.8 EFA80093.1 - 0.06 12.0 0.2 0.13 10.9 0.2 1.5 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like Mg_chelatase PF01078.21 EFA80093.1 - 0.12 11.8 0.0 0.26 10.6 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Coiled PF05710.12 EFA80094.1 - 0.26 12.1 14.2 0.4 11.5 14.2 1.4 1 1 0 1 1 1 0 Coiled coil CLU PF13236.6 EFA80095.1 - 3.8e-56 190.4 0.0 1.2e-55 188.7 0.0 1.9 1 0 0 1 1 1 1 Clustered mitochondria VHP PF02209.19 EFA80095.1 - 2e-11 43.8 5.0 2e-11 43.8 5.0 3.5 3 0 0 3 3 3 1 Villin headpiece domain LRR_4 PF12799.7 EFA80095.1 - 5.8e-11 42.5 53.7 0.005 17.2 1.0 11.1 8 4 0 11 11 11 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFA80095.1 - 1.2e-06 28.1 31.8 3.2 8.0 0.0 12.8 15 0 0 15 15 15 3 Leucine Rich repeat TPR_17 PF13431.6 EFA80095.1 - 3.9e-05 23.7 0.0 0.065 13.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat eIF3_p135 PF12807.7 EFA80095.1 - 0.00019 21.5 1.8 0.00019 21.5 1.8 3.8 2 1 1 3 3 3 1 Translation initiation factor eIF3 subunit 135 TPR_11 PF13414.6 EFA80095.1 - 0.024 14.3 0.4 0.024 14.3 0.4 2.7 4 0 0 4 4 4 0 TPR repeat GST_N PF02798.20 EFA80096.1 - 1.8e-14 53.8 0.0 3.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA80096.1 - 1.6e-13 50.8 0.0 3.5e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA80096.1 - 2.4e-13 50.2 0.0 8.4e-13 48.4 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA80096.1 - 2.6e-12 46.8 0.0 5e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA80096.1 - 2e-10 40.8 0.2 4.6e-10 39.6 0.1 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA80096.1 - 3.2e-07 30.3 0.0 8.5e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EFA80096.1 - 0.032 14.6 0.0 0.079 13.3 0.0 1.6 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein DUF3915 PF13054.6 EFA80097.1 - 0.063 13.3 2.2 0.13 12.2 2.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Ank_3 PF13606.6 EFA80097.1 - 0.09 13.4 0.9 1.4e+02 3.6 0.0 5.6 7 0 0 7 7 7 0 Ankyrin repeat MMR_HSR1 PF01926.23 EFA80098.1 - 1.9e-06 27.9 0.1 1.9e-06 27.9 0.1 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA80098.1 - 1e-05 25.0 0.4 1e-05 25.0 0.4 2.5 1 1 1 2 2 2 1 AIG1 family AAA_17 PF13207.6 EFA80098.1 - 0.00053 20.4 6.6 0.12 12.8 0.0 3.2 2 1 1 3 3 3 2 AAA domain SRPRB PF09439.10 EFA80098.1 - 0.0034 16.8 2.0 0.029 13.8 0.0 2.4 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EFA80098.1 - 0.0037 17.6 0.1 0.019 15.4 0.0 2.0 1 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFA80098.1 - 0.0081 16.1 0.4 0.0081 16.1 0.4 2.8 2 2 1 3 3 3 1 RsgA GTPase RNA_helicase PF00910.22 EFA80098.1 - 0.073 13.5 1.9 0.2 12.1 0.0 2.7 3 1 0 3 3 2 0 RNA helicase AAA_22 PF13401.6 EFA80098.1 - 0.074 13.3 7.2 0.45 10.8 0.7 3.4 1 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFA80098.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 EFA80098.1 - 0.27 10.8 4.4 6.3 6.3 0.1 2.9 2 2 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EFA80098.1 - 0.3 11.5 0.1 0.3 11.5 0.1 2.9 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) CorC_HlyC PF03471.17 EFA80098.1 - 0.31 11.1 2.1 0.45 10.6 0.4 2.1 3 0 0 3 3 3 0 Transporter associated domain MeaB PF03308.16 EFA80098.1 - 0.64 8.9 3.8 3.8 6.4 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB UPF0242 PF06785.11 EFA80098.1 - 0.91 9.6 17.4 1.4 9.0 17.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TORC_N PF12884.7 EFA80098.1 - 2.6 8.9 7.0 1.7 9.5 3.8 2.3 1 1 1 2 2 2 0 Transducer of regulated CREB activity, N terminus AAA_18 PF13238.6 EFA80098.1 - 3.7 8.1 8.2 1.1 9.8 0.4 2.6 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA80098.1 - 6.5 7.3 10.7 2.2e+02 2.3 10.7 2.7 1 1 0 1 1 1 0 ABC transporter F-box_5 PF18511.1 EFA80099.1 - 1.2e-05 24.7 0.0 2.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 F-box FNIP PF05725.12 EFA80099.1 - 0.00046 20.3 22.1 0.0091 16.1 0.1 7.2 5 1 1 6 6 6 3 FNIP Repeat F-box-like PF12937.7 EFA80099.1 - 0.0069 16.3 0.7 0.013 15.4 0.1 1.8 2 0 0 2 2 2 1 F-box-like PurL_C PF16904.5 EFA80099.1 - 0.01 16.1 0.4 0.26 11.6 0.0 2.6 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus F-box PF00646.33 EFA80099.1 - 0.025 14.5 2.0 0.052 13.5 0.2 2.3 2 0 0 2 2 2 0 F-box domain FNIP PF05725.12 EFA80100.1 - 7.4e-29 99.7 27.4 1.2e-13 50.9 0.4 7.6 5 2 2 8 8 8 6 FNIP Repeat LRR_4 PF12799.7 EFA80100.1 - 0.23 12.0 12.5 4.7 7.8 0.5 5.8 2 1 2 5 5 5 0 Leucine Rich repeats (2 copies) ORF45 PF17620.2 EFA80101.1 - 0.00015 22.0 2.7 0.00027 21.1 2.7 1.4 1 0 0 1 1 1 1 Family of unknown function FNIP PF05725.12 EFA80101.1 - 0.01 16.0 49.3 0.012 15.8 0.3 9.6 7 2 2 9 9 9 0 FNIP Repeat F-box_5 PF18511.1 EFA80101.1 - 0.063 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 EFA80101.1 - 0.095 12.6 0.7 0.25 11.3 0.1 2.0 2 0 0 2 2 2 0 F-box-like MMR_HSR1 PF01926.23 EFA80102.1 - 3.7e-06 27.0 0.0 3.7e-06 27.0 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA80102.1 - 0.00039 19.8 4.6 0.00039 19.8 4.6 2.3 1 1 1 2 2 2 1 AIG1 family AAA_16 PF13191.6 EFA80102.1 - 0.0043 17.5 0.1 0.011 16.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFA80102.1 - 0.007 16.3 0.3 0.007 16.3 0.3 2.6 2 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFA80102.1 - 0.073 13.3 5.4 0.26 11.6 0.3 2.9 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 EFA80102.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.6 EFA80102.1 - 0.14 12.6 11.9 0.14 12.5 0.3 3.2 1 1 2 3 3 3 0 AAA domain RNA_helicase PF00910.22 EFA80102.1 - 0.16 12.3 2.8 0.18 12.2 0.0 2.6 3 1 1 4 4 4 0 RNA helicase MeaB PF03308.16 EFA80102.1 - 0.57 9.1 3.6 3.2 6.6 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EFA80102.1 - 0.85 10.1 5.7 0.5 10.8 1.6 2.6 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) TORC_N PF12884.7 EFA80102.1 - 1.4 9.8 6.3 1.6 9.5 4.5 2.1 1 1 0 1 1 1 0 Transducer of regulated CREB activity, N terminus UPF0242 PF06785.11 EFA80102.1 - 1.7 8.7 16.7 2.3 8.3 16.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ABC_tran PF00005.27 EFA80102.1 - 3.6 8.1 9.7 63 4.1 9.7 2.5 1 1 0 1 1 1 0 ABC transporter Myosin_tail_1 PF01576.19 EFA80105.1 - 0.03 12.1 1.6 0.046 11.5 1.6 1.1 1 0 0 1 1 1 0 Myosin tail ERG4_ERG24 PF01222.17 EFA80109.1 - 8.7e-128 426.7 20.1 1.1e-127 426.4 20.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFA80109.1 - 0.0035 16.9 1.5 0.0035 16.9 1.5 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) RIO1 PF01163.22 EFA80111.1 - 6.6e-49 166.1 0.2 6.6e-49 166.1 0.2 1.8 2 0 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 EFA80111.1 - 5.2e-31 106.7 0.1 1.4e-30 105.3 0.1 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EFA80111.1 - 1.6e-09 38.0 0.1 0.00044 20.3 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFA80111.1 - 1.7e-07 30.9 0.0 1.7e-06 27.6 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RRN3 PF05327.11 EFA80111.1 - 0.059 11.9 23.4 0.096 11.2 23.4 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pkinase PF00069.25 EFA80111.1 - 0.086 12.2 2.7 0.088 12.2 0.2 2.2 2 1 0 2 2 2 0 Protein kinase domain NOA36 PF06524.12 EFA80111.1 - 0.14 11.5 34.5 0.28 10.5 34.5 1.5 1 0 0 1 1 1 0 NOA36 protein BUD22 PF09073.10 EFA80111.1 - 2 7.7 35.3 3 7.1 35.3 1.2 1 0 0 1 1 1 0 BUD22 LAP1C PF05609.12 EFA80111.1 - 6.5 5.7 25.5 9.4 5.2 25.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nuf2 PF03800.14 EFA80112.1 - 2.1e-30 105.7 0.3 2.1e-30 105.7 0.3 2.4 3 1 0 3 3 3 1 Nuf2 family DHR10 PF18595.1 EFA80112.1 - 6.4e-16 58.5 13.2 6.4e-16 58.5 13.2 4.2 2 2 2 4 4 4 1 Designed helical repeat protein 10 domain CENP-F_leu_zip PF10473.9 EFA80112.1 - 1.2e-05 25.3 5.0 1.2e-05 25.3 5.0 3.8 1 1 2 3 3 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 EFA80112.1 - 7.2e-05 22.2 35.9 0.0035 16.7 5.0 3.9 1 1 3 4 4 4 3 Protein of unknown function (DUF3450) JIP_LZII PF16471.5 EFA80112.1 - 0.00093 19.3 0.9 0.00093 19.3 0.9 5.8 3 1 4 7 7 6 1 JNK-interacting protein leucine zipper II Laminin_II PF06009.12 EFA80112.1 - 0.0026 17.8 29.3 0.017 15.2 3.3 4.0 1 1 3 4 4 4 2 Laminin Domain II DUF3584 PF12128.8 EFA80112.1 - 0.011 13.3 34.4 0.01 13.4 32.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EFA80112.1 - 0.015 14.2 41.6 0.89 8.4 10.7 3.2 2 1 2 4 4 4 0 Spc7 kinetochore protein APC_N_CC PF16689.5 EFA80112.1 - 0.058 13.5 9.6 0.064 13.3 3.2 3.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain TPR_MLP1_2 PF07926.12 EFA80112.1 - 0.075 13.1 41.1 0.26 11.4 7.7 3.8 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein Remorin_N PF03766.13 EFA80112.1 - 0.13 12.3 0.5 0.36 10.9 0.5 1.7 1 0 0 1 1 1 0 Remorin, N-terminal region THOC7 PF05615.13 EFA80112.1 - 0.14 12.5 35.9 1.2 9.4 9.9 3.5 2 1 2 4 4 4 0 Tho complex subunit 7 DivIVA PF05103.13 EFA80112.1 - 0.18 11.9 38.3 0.27 11.3 1.5 5.2 1 1 2 4 4 4 0 DivIVA protein HMMR_N PF15905.5 EFA80112.1 - 0.18 11.2 46.7 0.64 9.4 17.2 3.1 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal Corona_S2 PF01601.16 EFA80112.1 - 0.23 9.9 12.9 0.2 10.1 3.0 2.3 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein PAH PF02671.21 EFA80112.1 - 0.29 11.3 2.0 0.63 10.2 0.6 2.5 2 0 0 2 2 1 0 Paired amphipathic helix repeat DUF812 PF05667.11 EFA80112.1 - 0.34 9.7 45.1 1.3 7.8 34.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF745 PF05335.13 EFA80112.1 - 0.37 10.5 21.1 0.81 9.4 0.8 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF745) Baculo_PEP_C PF04513.12 EFA80112.1 - 0.37 10.8 18.9 0.42 10.6 1.5 3.9 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Seryl_tRNA_N PF02403.22 EFA80112.1 - 0.94 9.7 41.2 0.13 12.5 10.8 4.5 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain CALCOCO1 PF07888.11 EFA80112.1 - 2.4 6.9 37.4 0.13 11.1 20.1 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like OmpH PF03938.14 EFA80112.1 - 2.8 8.3 40.7 0.25 11.7 2.8 3.6 1 1 2 3 3 2 0 Outer membrane protein (OmpH-like) RasGAP_C PF03836.15 EFA80112.1 - 3.3 7.9 40.5 0.31 11.2 4.5 4.9 1 1 3 4 4 4 0 RasGAP C-terminus MCPsignal PF00015.21 EFA80112.1 - 3.7 7.3 18.1 2.3 8.0 0.4 3.8 1 1 3 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Rootletin PF15035.6 EFA80112.1 - 4 7.4 32.1 2.1 8.3 25.2 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion APG6_N PF17675.1 EFA80112.1 - 4.4 7.8 50.4 0.49 10.9 19.7 3.6 2 1 1 4 4 3 0 Apg6 coiled-coil region Fib_alpha PF08702.10 EFA80112.1 - 6.4 7.0 44.0 0.048 13.9 13.0 3.5 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EFA80112.1 - 8.1 5.7 24.7 3.5 6.9 5.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 EFA80112.1 - 8.5 6.7 20.9 2.2 8.6 0.8 4.5 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EFA80112.1 - 9.8 6.2 38.4 1.7 8.7 4.4 5.1 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) DUF1713 PF08213.11 EFA80113.1 - 1.2e-10 41.1 23.0 1.9e-10 40.5 23.0 1.3 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) DMPK_coil PF08826.10 EFA80113.1 - 0.022 14.9 2.2 0.036 14.2 2.2 1.4 1 0 0 1 1 1 0 DMPK coiled coil domain like WD40 PF00400.32 EFA80114.1 - 6.7e-11 42.6 10.3 3.1e-05 24.6 0.3 3.7 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80114.1 - 0.0012 19.1 1.1 0.0082 16.4 0.6 2.2 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ntox21 PF15526.6 EFA80114.1 - 0.28 11.5 1.7 0.56 10.5 0.3 2.0 2 0 0 2 2 2 0 Novel toxin 21 W_rich_C PF07483.11 EFA80114.1 - 0.36 11.0 4.1 0.36 11.0 2.8 1.7 2 0 0 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain AI-2E_transport PF01594.16 EFA80115.1 - 1.9 7.6 6.3 5.2 6.1 6.3 1.7 1 0 0 1 1 1 0 AI-2E family transporter MS_channel PF00924.18 EFA80116.1 - 3.9e-26 91.9 2.0 3.9e-26 91.9 2.0 2.0 2 0 0 2 2 2 1 Mechanosensitive ion channel FKS1_dom1 PF14288.6 EFA80117.1 - 0.008 16.5 0.4 0.0099 16.2 0.4 1.4 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 K_oxygenase PF13434.6 EFA80117.1 - 0.059 12.5 0.3 0.064 12.4 0.3 1.0 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Suc_Fer-like PF06999.12 EFA80118.1 - 2e-39 135.5 0.0 3.1e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Orthopox_A5L PF06193.11 EFA80118.1 - 0.047 13.1 7.3 0.075 12.5 7.3 1.2 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like DUF3439 PF11921.8 EFA80118.1 - 0.58 10.1 6.2 1.1 9.2 6.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DLH PF01738.18 EFA80120.1 - 1.1e-34 120.0 0.0 1.2e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EFA80120.1 - 0.00058 19.4 1.5 0.15 11.5 0.2 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFA80120.1 - 0.0026 17.4 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EFA80120.1 - 0.061 13.2 1.9 2.5 7.9 0.0 2.3 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal EB1 PF03271.17 EFA80121.1 - 3e-11 43.4 0.4 3e-11 43.4 0.4 2.1 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 EFA80121.1 - 9.3e-10 38.7 0.1 2.1e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain TFIIA PF03153.13 EFA80121.1 - 1.1e-05 25.6 2.6 1.6e-05 25.1 2.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Hrs_helical PF12210.8 EFA80121.1 - 0.035 14.6 0.1 0.072 13.6 0.1 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate CH_2 PF06294.11 EFA80121.1 - 0.036 14.2 0.0 0.094 12.8 0.1 1.8 1 1 0 1 1 1 0 CH-like domain in sperm protein SOG2 PF10428.9 EFA80121.1 - 0.051 12.8 7.1 0.068 12.4 7.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Ribonuc_red_lgC PF02867.15 EFA80121.1 - 0.055 12.0 0.6 0.093 11.3 0.6 1.3 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain CCDC106 PF15794.5 EFA80121.1 - 0.23 11.2 3.9 0.43 10.3 3.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CASP_C PF08172.12 EFA80121.1 - 7.3 5.8 9.4 0.21 10.9 2.8 1.7 2 0 0 2 2 2 0 CASP C terminal Ank_2 PF12796.7 EFA80122.1 - 1.1e-36 125.3 16.1 4.2e-10 40.1 0.1 3.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80122.1 - 4.8e-32 109.9 5.2 3.4e-12 46.6 0.3 6.6 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFA80122.1 - 2.5e-27 94.1 10.6 9e-08 32.2 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFA80122.1 - 1.9e-24 85.4 4.4 6.4e-09 35.9 0.0 5.7 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80122.1 - 2.5e-23 79.6 5.7 3.9e-06 26.8 0.0 6.9 6 0 0 6 6 6 4 Ankyrin repeat TIG PF01833.24 EFA80122.1 - 3e-13 49.7 0.1 1.1e-12 47.8 0.1 2.1 1 0 0 1 1 1 1 IPT/TIG domain AAA PF00004.29 EFA80123.1 - 3.2e-51 173.2 0.0 2.5e-37 128.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA80123.1 - 2.6e-09 36.7 0.0 5e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EFA80123.1 - 4.5e-09 36.7 0.2 0.0013 19.0 0.0 3.6 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EFA80123.1 - 9.5e-09 35.9 0.4 0.00077 20.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EFA80123.1 - 1.1e-08 35.2 0.0 0.00017 21.6 0.1 2.8 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA80123.1 - 3.7e-08 33.9 0.0 0.0027 18.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EFA80123.1 - 7.4e-08 32.7 0.0 0.0058 16.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EFA80123.1 - 1.5e-07 31.7 0.1 1.2e-05 25.5 0.1 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFA80123.1 - 1.9e-07 31.0 0.0 0.0098 15.6 0.1 2.9 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFA80123.1 - 3.4e-06 26.5 0.0 0.0058 15.9 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 EFA80123.1 - 9e-06 25.2 1.1 0.0048 16.3 0.2 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EFA80123.1 - 1.1e-05 25.5 0.0 0.21 11.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EFA80123.1 - 1.5e-05 25.0 2.7 1.2 9.1 0.1 3.6 4 0 0 4 4 3 2 NACHT domain AAA_3 PF07726.11 EFA80123.1 - 1.5e-05 24.8 0.0 0.13 12.2 0.0 3.3 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFA80123.1 - 1.6e-05 25.2 0.0 0.091 13.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 EFA80123.1 - 1.6e-05 24.9 0.0 0.18 11.8 0.0 2.8 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EFA80123.1 - 5.2e-05 23.0 0.1 0.32 10.7 0.1 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_24 PF13479.6 EFA80123.1 - 0.00013 21.8 0.1 0.38 10.5 0.0 2.6 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EFA80123.1 - 0.00014 22.4 1.1 0.044 14.3 0.1 2.6 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 EFA80123.1 - 0.00022 20.8 0.1 0.015 14.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EFA80123.1 - 0.00024 20.9 0.0 0.72 9.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 EFA80123.1 - 0.00027 21.2 0.1 0.26 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFA80123.1 - 0.00027 20.3 0.1 0.053 12.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin CDC48_2 PF02933.17 EFA80123.1 - 0.00058 19.6 0.4 0.44 10.4 0.0 3.7 3 0 0 3 3 3 1 Cell division protein 48 (CDC48), domain 2 ATPase PF06745.13 EFA80123.1 - 0.0028 17.0 0.7 0.1 12.0 0.0 2.7 3 0 0 3 3 2 1 KaiC AAA_11 PF13086.6 EFA80123.1 - 0.0033 17.2 0.2 0.061 13.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain CPT PF07931.12 EFA80123.1 - 0.004 17.0 0.1 0.7 9.7 0.0 2.3 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein DUF2075 PF09848.9 EFA80123.1 - 0.0043 16.3 0.5 0.54 9.4 0.1 2.8 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 EFA80123.1 - 0.0052 16.0 0.2 0.44 9.7 0.1 2.4 2 0 0 2 2 2 1 NB-ARC domain DUF815 PF05673.13 EFA80123.1 - 0.0071 15.5 0.0 0.2 10.8 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) KTI12 PF08433.10 EFA80123.1 - 0.0077 15.7 0.1 2.6 7.4 0.0 2.5 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 EFA80123.1 - 0.0093 16.4 0.1 2.2 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA80123.1 - 0.011 15.5 0.0 0.23 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFA80123.1 - 0.014 15.0 1.1 3.5 7.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EFA80123.1 - 0.017 14.9 0.0 7 6.3 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TniB PF05621.11 EFA80123.1 - 0.018 14.5 0.3 4.9 6.5 0.2 3.4 2 1 0 2 2 2 0 Bacterial TniB protein Sigma54_activ_2 PF14532.6 EFA80123.1 - 0.022 14.9 0.0 12 6.0 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 EFA80123.1 - 0.023 14.4 0.1 3.8 7.2 0.1 2.4 2 0 0 2 2 2 0 Cytidylate kinase T2SSE PF00437.20 EFA80123.1 - 0.041 12.9 0.0 1.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EFA80123.1 - 0.052 13.5 0.5 2.6 7.9 0.0 2.8 2 1 0 2 2 2 0 NTPase AAA_29 PF13555.6 EFA80123.1 - 0.064 13.0 0.7 4.1 7.2 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Torsin PF06309.11 EFA80123.1 - 0.081 13.0 0.0 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Torsin Rad17 PF03215.15 EFA80123.1 - 0.082 12.8 0.5 9.7 6.1 0.1 3.2 3 1 1 4 4 4 0 Rad17 P-loop domain Parvo_NS1 PF01057.17 EFA80123.1 - 0.095 11.8 0.0 0.99 8.4 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Hydin_ADK PF17213.3 EFA80123.1 - 0.12 12.6 0.1 12 6.1 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain PhoH PF02562.16 EFA80123.1 - 0.12 11.8 0.1 5 6.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 EFA80123.1 - 0.12 12.6 1.1 1 9.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFA80123.1 - 0.52 10.8 3.0 0.38 11.2 0.4 2.0 2 0 0 2 2 2 0 AAA domain Spore_YhcN_YlaJ PF09580.10 EFA80124.1 - 0.00036 20.6 0.4 0.00036 20.6 0.4 3.2 2 1 0 2 2 2 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) SAP PF02037.27 EFA80124.1 - 0.15 11.8 0.0 0.41 10.4 0.1 1.7 2 0 0 2 2 2 0 SAP domain FA_desaturase PF00487.24 EFA80124.1 - 0.33 10.8 5.6 0.57 10.0 5.6 1.3 1 0 0 1 1 1 0 Fatty acid desaturase RcpC PF16976.5 EFA80124.1 - 0.56 10.3 9.8 1.5 8.8 9.8 1.7 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB DUF3464 PF11947.8 EFA80124.1 - 0.85 9.4 11.2 68 3.2 12.5 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 MPP6 PF10175.9 EFA80124.1 - 2.2 8.8 9.7 0.55 10.7 5.8 2.0 2 0 0 2 2 2 0 M-phase phosphoprotein 6 Sec62 PF03839.16 EFA80124.1 - 2.7 7.5 8.9 6.9 6.1 8.9 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 DUF702 PF05142.12 EFA80124.1 - 5.6 7.4 16.6 1.4 9.3 5.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF702) FHIPEP PF00771.20 EFA80124.1 - 7.8 4.8 8.4 13 4.1 8.4 1.2 1 0 0 1 1 1 0 FHIPEP family Glyco_hydro_15 PF00723.21 EFA80125.1 - 9.7e-16 57.6 0.0 1e-13 50.9 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Porin_3 PF01459.22 EFA80126.1 - 4.6e-36 124.7 1.5 5.3e-36 124.5 1.5 1.0 1 0 0 1 1 1 1 Eukaryotic porin Cyclin PF08613.11 EFA80127.1 - 1.3e-31 110.1 0.3 1.3e-31 110.1 0.3 2.5 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFA80127.1 - 2.6e-09 36.9 0.0 5.1e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Macoilin PF09726.9 EFA80127.1 - 4.2 5.8 7.4 4.9 5.6 7.4 1.2 1 0 0 1 1 1 0 Macoilin family HobA PF12163.8 EFA80128.1 - 0.0022 17.6 0.7 0.0024 17.5 0.7 1.1 1 0 0 1 1 1 1 DNA replication regulator DUF5421 PF17458.2 EFA80128.1 - 0.0051 16.3 1.5 0.0059 16.0 1.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5421) CENP-O PF09496.10 EFA80128.1 - 0.016 15.2 0.9 0.021 14.8 0.9 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DUF2512 PF10710.9 EFA80128.1 - 0.17 11.5 0.2 0.17 11.5 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) COX14 PF14880.6 EFA80128.1 - 0.86 9.5 2.4 1.5 8.8 2.4 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Androgen_recep PF02166.16 EFA80128.1 - 7.3 5.3 9.4 8.2 5.1 9.4 1.1 1 0 0 1 1 1 0 Androgen receptor SAP30_Sin3_bdg PF13867.6 EFA80129.1 - 4.6e-18 65.3 0.0 1.4e-17 63.7 0.0 1.9 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 HMG_box PF00505.19 EFA80129.1 - 1.9e-06 28.2 26.9 0.0056 17.1 0.8 5.6 5 0 0 5 5 5 4 HMG (high mobility group) box HMG_box_2 PF09011.10 EFA80129.1 - 0.0043 17.6 25.4 0.069 13.7 2.6 5.0 3 2 1 4 4 4 2 HMG-box domain FtsL PF04999.13 EFA80129.1 - 0.014 15.4 0.9 0.035 14.1 0.9 1.7 1 0 0 1 1 1 0 Cell division protein FtsL PGBA_C PF15437.6 EFA80129.1 - 2.5 8.5 16.0 0.18 12.2 4.4 3.1 3 0 0 3 3 3 0 Plasminogen-binding protein pgbA C-terminal Yippee-Mis18 PF03226.14 EFA80131.1 - 2.7e-08 34.0 0.2 2.9e-08 33.8 0.2 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RNA_pol_N PF01194.17 EFA80131.1 - 0.11 12.9 0.5 0.14 12.4 0.5 1.2 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit MazG_C PF18722.1 EFA80131.1 - 0.14 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 MazG C-terminal domain Gar1 PF04410.14 EFA80132.1 - 9.7e-30 103.4 4.6 1.5e-19 70.3 0.0 5.2 3 2 1 5 5 5 2 Gar1/Naf1 RNA binding region SR-25 PF10500.9 EFA80132.1 - 0.0017 18.0 15.9 0.0017 18.0 15.9 3.8 3 1 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF3439 PF11921.8 EFA80132.1 - 2.1 8.3 8.1 6.2 6.8 8.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Hydrolase_4 PF12146.8 EFA80133.1 - 1.4e-57 194.7 0.0 1.7e-57 194.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EFA80133.1 - 1.1e-07 31.9 0.4 0.034 13.9 0.0 2.9 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EFA80133.1 - 3.9e-06 26.7 0.1 0.0049 16.6 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA80133.1 - 4.7e-05 24.1 0.0 5.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EFA80133.1 - 0.01 15.4 0.0 3.3 7.2 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 EFA80133.1 - 0.022 13.4 0.0 3.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DLH PF01738.18 EFA80133.1 - 0.063 12.8 0.0 0.51 9.9 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family Amino_oxidase PF01593.24 EFA80134.1 - 1.7e-18 67.1 0.0 5.5e-16 58.9 0.0 2.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFA80134.1 - 5.2e-08 33.0 0.2 1e-07 32.1 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFA80134.1 - 2.9e-05 23.6 0.1 7.8e-05 22.2 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFA80134.1 - 3.3e-05 22.8 0.6 0.0022 16.8 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFA80134.1 - 0.00018 21.2 0.0 0.00034 20.3 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFA80134.1 - 0.00028 20.1 0.3 0.00051 19.2 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFA80134.1 - 0.00044 20.8 1.3 0.81 10.3 0.3 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFA80134.1 - 0.00099 18.4 0.3 0.0016 17.8 0.3 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EFA80134.1 - 0.0021 17.4 0.5 0.65 9.2 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA80134.1 - 0.0031 16.6 0.3 0.0045 16.1 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EFA80134.1 - 0.0052 16.8 0.5 0.014 15.4 0.3 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFA80134.1 - 0.013 14.8 0.9 0.024 13.9 0.9 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 EFA80134.1 - 0.033 13.3 0.4 0.48 9.5 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Rad60-SLD PF11976.8 EFA80134.1 - 0.13 12.1 1.9 1 9.3 0.1 2.6 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Trp_halogenase PF04820.14 EFA80134.1 - 0.17 10.7 0.2 0.25 10.2 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase DUF3546 PF12066.8 EFA80136.1 - 5.7e-30 103.8 10.3 2.7e-29 101.6 10.3 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 EFA80136.1 - 3.4e-17 63.5 1.5 3.4e-17 63.5 1.5 3.3 3 1 1 4 4 4 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 EFA80136.1 - 6.6e-09 35.4 2.1 1.6e-08 34.2 2.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) RRM_1 PF00076.22 EFA80136.1 - 1.4e-06 28.1 0.0 4e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_2 PF12756.7 EFA80136.1 - 0.15 12.4 13.2 0.33 11.3 2.7 3.6 3 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Cyclin PF08613.11 EFA80137.1 - 1.3e-26 93.9 1.2 1.3e-26 93.9 1.2 3.0 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 EFA80137.1 - 3.4e-10 39.8 0.1 3.4e-10 39.8 0.1 2.2 3 0 0 3 3 3 1 Cyclin, N-terminal domain Chlam_PMP PF02415.17 EFA80137.1 - 0.26 11.9 0.1 0.26 11.9 0.1 3.0 2 2 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat NDK PF00334.19 EFA80138.1 - 9.3e-34 116.4 0.0 1.1e-33 116.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Vps54 PF07928.12 EFA80139.1 - 6.6e-42 143.1 0.3 6.6e-42 143.1 0.3 2.9 2 0 0 2 2 2 1 Vps54-like protein MTP18 PF10558.9 EFA80139.1 - 0.74 9.8 5.1 0.85 9.6 3.1 2.1 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF2722 PF10846.8 EFA80139.1 - 8.1 5.3 45.5 0.036 13.0 12.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) Ctr PF04145.15 EFA80139.1 - 8.6 7.0 8.4 15 6.2 1.1 3.8 4 0 0 4 4 4 0 Ctr copper transporter family Peroxin-13_N PF04088.13 EFA80139.1 - 9.1 6.6 12.6 33 4.7 4.2 3.9 3 0 0 3 3 3 0 Peroxin 13, N-terminal region RRM_1 PF00076.22 EFA80140.1 - 1e-05 25.2 0.1 3.4e-05 23.6 0.1 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 EFA80140.1 - 0.00031 20.5 4.1 0.00059 19.7 4.1 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PWI PF01480.17 EFA80140.1 - 0.0012 19.1 0.0 0.0033 17.7 0.0 1.8 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.6 EFA80140.1 - 0.02 14.9 0.0 0.047 13.7 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EFA80140.1 - 0.09 12.7 0.5 0.67 9.9 0.5 2.4 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH_2 PF14608.6 EFA80140.1 - 0.33 11.5 4.0 0.57 10.7 4.0 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger HSP20 PF00011.21 EFA80141.1 - 3.4e-13 49.6 1.0 3.4e-13 49.6 1.0 2.5 2 1 0 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA80141.1 - 9.1e-06 25.1 0.0 1.9e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFA80141.1 - 0.0054 17.7 1.1 0.011 16.7 1.1 1.6 1 1 0 1 1 1 1 CS domain DUF1798 PF08807.10 EFA80141.1 - 0.075 13.2 0.6 0.075 13.2 0.6 2.1 2 0 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) DUF747 PF05346.11 EFA80142.1 - 1.6e-92 310.4 8.8 2.5e-92 309.8 8.8 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family RNA_pol_3_Rpc31 PF11705.8 EFA80142.1 - 0.00013 22.3 27.3 0.0066 16.7 11.2 2.7 2 0 0 2 2 2 2 DNA-directed RNA polymerase III subunit Rpc31 Presenilin PF01080.17 EFA80142.1 - 0.0031 16.3 5.8 0.0031 16.3 5.8 4.8 3 2 0 3 3 3 1 Presenilin MAGE_N PF12440.8 EFA80142.1 - 0.066 13.9 0.0 0.066 13.9 0.0 6.0 4 1 0 4 4 4 0 Melanoma associated antigen family N terminal PBP1_TM PF14812.6 EFA80142.1 - 0.36 11.2 37.7 0.12 12.8 10.9 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal THEG4 PF15834.5 EFA80142.1 - 2.6 8.0 8.3 5.5 6.9 0.5 3.3 3 0 0 3 3 3 0 Testis highly expressed protein 4 FYDLN_acid PF09538.10 EFA80142.1 - 7.5 7.3 39.1 2.8 8.7 7.9 3.5 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Rubis-subs-bind PF09273.11 EFA80143.1 - 4.2e-23 82.5 5.8 7.5e-23 81.6 4.6 1.9 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.28 EFA80143.1 - 4.7e-11 43.4 0.3 2.5e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 SET domain OGG_N PF07934.12 EFA80143.1 - 0.35 11.0 3.1 0.25 11.4 1.2 1.8 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain OsmC PF02566.19 EFA80144.1 - 3.6e-14 53.1 0.2 4.6e-14 52.7 0.2 1.1 1 0 0 1 1 1 1 OsmC-like protein tRNA_bind PF01588.20 EFA80145.1 - 1.1e-21 76.7 0.5 1.4e-13 50.7 0.0 2.2 2 0 0 2 2 2 2 Putative tRNA binding domain DUF2244 PF10003.9 EFA80146.1 - 0.056 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Cyto_heme_lyase PF01265.17 EFA80147.1 - 3.7e-63 213.8 2.7 4.4e-63 213.6 2.7 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase FTCD_C PF04961.12 EFA80147.1 - 0.14 11.9 0.9 0.19 11.5 0.9 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase SUIM_assoc PF16619.5 EFA80147.1 - 0.47 10.5 5.8 0.15 12.1 1.5 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RasGAP PF00616.19 EFA80148.1 - 3.6e-40 137.9 0.4 3.6e-40 137.9 0.4 4.1 4 2 0 4 4 4 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 EFA80148.1 - 4e-33 113.9 0.5 8.2e-17 61.4 0.0 3.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA80148.1 - 0.085 12.7 0.1 0.36 10.7 0.1 2.1 1 0 0 1 1 1 0 CAMSAP CH domain BAR PF03114.18 EFA80149.1 - 0.038 13.6 11.0 0.28 10.8 11.0 2.0 1 1 0 1 1 1 0 BAR domain DUF643 PF04867.12 EFA80149.1 - 0.35 11.5 4.0 0.27 11.8 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF643) RecG_N PF17190.4 EFA80149.1 - 2.8 8.7 10.8 10 6.9 2.2 2.9 2 1 1 3 3 3 0 RecG N-terminal helical domain LMBR1 PF04791.16 EFA80149.1 - 3.4 6.5 4.8 4.5 6.1 4.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Transglut_core PF01841.19 EFA80150.1 - 1.2e-12 48.3 0.0 2.5e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily BAR PF03114.18 EFA80150.1 - 0.00033 20.4 4.8 0.0005 19.8 4.8 1.2 1 0 0 1 1 1 1 BAR domain Sec34 PF04136.15 EFA80151.1 - 3.7e-30 104.8 8.3 3.7e-30 104.8 8.3 3.0 3 0 0 3 3 3 1 Sec34-like family Roughex PF06020.11 EFA80151.1 - 0.54 9.3 5.8 0.95 8.5 5.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Prefoldin_2 PF01920.20 EFA80152.1 - 2.5e-14 53.1 8.6 3.3e-14 52.7 8.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EFA80152.1 - 2.1e-05 24.4 7.3 0.00019 21.4 1.2 2.2 2 0 0 2 2 2 2 Prefoldin subunit DUF5320 PF17253.2 EFA80152.1 - 0.0026 18.8 3.8 0.025 15.6 0.5 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5320) Snf7 PF03357.21 EFA80152.1 - 0.0057 16.3 7.3 0.2 11.3 0.2 2.1 2 0 0 2 2 2 2 Snf7 DUF2714 PF10896.8 EFA80152.1 - 0.0089 16.1 3.0 1.2 9.2 0.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2714) RNA_polI_A14 PF08203.11 EFA80152.1 - 0.0099 16.6 1.3 0.054 14.2 0.1 2.0 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 KxDL PF10241.9 EFA80152.1 - 0.013 15.7 2.0 0.61 10.4 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF3450 PF11932.8 EFA80152.1 - 0.029 13.7 4.9 0.16 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) LRS4 PF10422.9 EFA80152.1 - 0.099 12.2 3.2 0.12 11.9 3.2 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF4854 PF16146.5 EFA80152.1 - 0.26 11.6 6.0 0.89 9.9 4.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4854) NYD-SP28_assoc PF14775.6 EFA80152.1 - 0.27 11.4 6.1 0.55 10.4 1.0 2.2 2 0 0 2 2 2 0 Sperm tail C-terminal domain V_ATPase_I PF01496.19 EFA80152.1 - 0.31 8.9 4.0 0.37 8.7 4.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 EFA80152.1 - 0.6 10.2 4.1 3.2 7.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EFA80152.1 - 0.91 9.7 6.0 0.81 9.9 0.2 2.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Spc19 PF08287.11 EFA80152.1 - 1 9.2 7.8 0.8 9.6 1.8 2.0 1 1 1 2 2 2 0 Spc19 Osmo_CC PF08946.10 EFA80152.1 - 2 8.7 10.8 0.74 10.1 4.2 2.5 2 1 0 2 2 2 0 Osmosensory transporter coiled coil Rho_Binding PF08912.11 EFA80152.1 - 2.8 8.8 12.2 1.5 9.7 1.7 2.5 1 1 0 2 2 2 0 Rho Binding WH2 PF02205.20 EFA80154.1 - 2.8e-05 23.8 5.3 0.12 12.3 0.0 3.5 4 0 0 4 4 4 2 WH2 motif Ribosomal_S25 PF03297.15 EFA80154.1 - 0.0064 16.7 0.1 0.0072 16.5 0.1 1.2 1 0 0 1 1 1 1 S25 ribosomal protein ddrB-ParB PF18763.1 EFA80154.1 - 0.047 13.8 0.3 1.3 9.1 0.1 2.0 1 1 1 2 2 2 0 ddrB-like ParB superfamily domain Pkinase_Tyr PF07714.17 EFA80155.1 - 8.8e-64 215.3 0.0 1.4e-63 214.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA80155.1 - 2e-59 201.1 0.0 6.4e-59 199.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain TIG PF01833.24 EFA80155.1 - 6e-11 42.3 4.5 6e-11 42.3 4.5 3.0 3 0 0 3 3 3 1 IPT/TIG domain TIG_plexin PF17960.1 EFA80155.1 - 0.0026 17.7 0.2 0.0095 15.9 0.2 2.0 1 0 0 1 1 1 1 TIG domain APH PF01636.23 EFA80155.1 - 0.026 14.5 0.3 0.05 13.5 0.3 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family CLU PF13236.6 EFA80156.1 - 5.5e-50 170.2 0.0 2.4e-49 168.2 0.0 2.1 2 0 0 2 2 2 1 Clustered mitochondria Ras PF00071.22 EFA80156.1 - 5.4e-39 133.4 1.0 1.5e-38 132.0 0.3 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFA80156.1 - 5.8e-23 81.4 0.1 1.6e-22 80.0 0.1 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA80156.1 - 5.6e-10 38.9 0.1 1e-09 38.1 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family eIF3_p135 PF12807.7 EFA80156.1 - 0.00035 20.7 0.0 0.00035 20.7 0.0 4.1 4 1 0 4 4 4 1 Translation initiation factor eIF3 subunit 135 TPR_8 PF13181.6 EFA80156.1 - 0.15 12.4 0.1 2.4 8.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat CobT PF06213.12 EFA80156.1 - 1.2 8.4 13.2 0.077 12.4 0.4 2.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Rhomboid PF01694.22 EFA80157.1 - 1.3e-12 48.0 7.8 2.6e-11 43.7 7.8 2.4 1 1 0 1 1 1 1 Rhomboid family Aminotran_1_2 PF00155.21 EFA80158.1 - 1.7e-76 257.8 0.0 4.3e-76 256.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II UBX PF00789.20 EFA80158.1 - 6e-19 68.0 0.2 1.8e-18 66.5 0.2 1.9 1 0 0 1 1 1 1 UBX domain Cys_Met_Meta_PP PF01053.20 EFA80158.1 - 5e-05 22.0 0.0 9.4e-05 21.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFA80158.1 - 5.9e-05 22.2 0.0 0.00014 21.0 0.0 1.6 1 0 0 1 1 1 1 Aminotransferase class-V Thioredoxin_7 PF13899.6 EFA80158.1 - 0.0017 18.5 0.1 0.0073 16.5 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like DUF2695 PF10905.8 EFA80158.1 - 0.05 13.8 0.2 0.47 10.7 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2695) M60-like_N PF17291.2 EFA80159.1 - 0.0073 16.2 4.6 11 6.0 0.0 4.7 4 0 0 4 4 4 2 N-terminal domain of M60-like peptidases Myb_DNA-binding PF00249.31 EFA80160.1 - 0.0039 17.4 0.4 0.011 15.9 0.4 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA80160.1 - 0.0095 16.2 0.9 0.042 14.1 0.9 2.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ten1_2 PF15490.6 EFA80161.1 - 3.2e-09 36.5 0.1 3e-08 33.4 0.1 2.1 1 1 0 1 1 1 1 Telomere-capping, CST complex subunit NDUFA12 PF05071.16 EFA80162.1 - 1.8e-10 41.5 0.3 2.2e-10 41.2 0.3 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DEAD PF00270.29 EFA80164.1 - 2.8e-40 138.0 1.8 4.5e-40 137.3 0.9 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA80164.1 - 2.4e-26 92.2 1.5 8.1e-26 90.6 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Shikimate_DH PF01488.20 EFA80164.1 - 0.013 15.5 2.1 0.99 9.5 0.1 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF2950 PF11453.8 EFA80164.1 - 0.081 12.1 0.1 4.4 6.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2950) GLTSCR1 PF15249.6 EFA80164.1 - 0.24 11.9 2.9 0.58 10.6 0.0 3.0 3 0 0 3 3 3 0 Conserved region of unknown function on GLTSCR protein Med22 PF06179.12 EFA80164.1 - 2.1 8.6 8.0 0.19 11.9 1.4 2.7 4 0 0 4 4 4 0 Surfeit locus protein 5 subunit 22 of Mediator complex TGT PF01702.18 EFA80165.1 - 4.4e-98 328.7 0.1 9.8e-71 238.7 0.0 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase HATPase_c PF02518.26 EFA80166.1 - 6e-27 94.4 0.0 1.5e-26 93.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA80166.1 - 4.4e-21 75.1 1.0 1.4e-20 73.5 0.3 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFA80166.1 - 1.7e-17 63.2 0.0 4.5e-17 61.8 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EFA80166.1 - 1e-06 28.9 0.3 3.2e-06 27.3 0.3 2.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFA80166.1 - 0.0035 17.6 0.0 0.0068 16.7 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EFA80166.1 - 0.022 14.8 0.1 0.061 13.3 0.1 1.8 1 0 0 1 1 1 0 PAS fold PQ-loop PF04193.14 EFA80167.1 - 0.00011 21.8 0.7 0.00059 19.6 1.3 2.0 2 0 0 2 2 2 1 PQ loop repeat Acyl_transf_3 PF01757.22 EFA80167.1 - 0.024 13.7 3.1 0.039 13.0 3.1 1.2 1 0 0 1 1 1 0 Acyltransferase family DUF2615 PF11027.8 EFA80167.1 - 0.032 14.4 4.8 0.083 13.0 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2615) OAD_gamma PF04277.13 EFA80167.1 - 0.12 13.0 0.6 3.1 8.5 0.1 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SpoIIIAH PF12685.7 EFA80167.1 - 0.15 11.9 14.7 0.2 11.5 10.4 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF2304 PF10066.9 EFA80167.1 - 0.21 11.8 2.3 3.7 7.8 0.7 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Miga PF10265.9 EFA80167.1 - 2.2 7.2 8.9 0.029 13.4 1.7 1.4 2 0 0 2 2 2 0 Mitoguardin Otopetrin PF03189.13 EFA80167.1 - 5.1 5.8 6.4 3.6 6.3 3.9 1.8 1 1 1 2 2 2 0 Otopetrin DUF4685 PF15737.5 EFA80167.1 - 7.1 7.1 7.2 0.67 10.4 1.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4685) FAM76 PF16046.5 EFA80167.1 - 9.4 5.5 11.5 0.13 11.6 4.3 1.5 2 0 0 2 2 2 0 FAM76 protein PX PF00787.24 EFA80169.1 - 2.7e-20 72.5 2.2 3.2e-20 72.2 2.2 1.1 1 0 0 1 1 1 1 PX domain Epimerase PF01370.21 EFA80170.1 - 3.8e-22 78.9 0.1 5.2e-22 78.5 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFA80170.1 - 5.8e-13 48.9 0.0 1.2e-12 47.9 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFA80170.1 - 2.3e-10 40.6 0.2 5.4e-10 39.5 0.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFA80170.1 - 2.6e-10 39.8 0.1 2e-09 36.9 0.1 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFA80170.1 - 6.6e-10 38.5 0.1 9.1e-10 38.1 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EFA80170.1 - 0.0056 15.9 1.2 0.041 13.1 1.2 2.4 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EFA80170.1 - 0.018 14.2 0.3 0.028 13.5 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1731 PF08338.11 EFA80170.1 - 0.027 14.3 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1731) KR PF08659.10 EFA80170.1 - 0.032 14.1 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 KR domain DnaB PF00772.21 EFA80170.1 - 0.049 13.7 0.1 1.9 8.6 0.0 2.4 1 1 1 2 2 2 0 DnaB-like helicase N terminal domain Acetyltransf_1 PF00583.25 EFA80171.1 - 2.8e-05 24.3 0.0 3.9e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA80171.1 - 0.0052 16.7 0.0 0.0058 16.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA80171.1 - 0.015 15.7 0.1 0.024 15.0 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1905 PF08922.11 EFA80171.1 - 0.042 13.9 0.0 0.059 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1905) Herpes_UL52 PF03121.15 EFA80172.1 - 1.1e-08 34.9 1.7 2e-08 34.1 0.4 2.0 2 0 0 2 2 2 1 Herpesviridae UL52/UL70 DNA primase PilM_2 PF11104.8 EFA80173.1 - 0.027 13.5 0.1 0.027 13.5 0.1 1.0 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; HSP70 PF00012.20 EFA80174.1 - 2.2e-251 835.3 9.4 2.5e-251 835.1 9.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFA80174.1 - 2.1e-16 59.6 0.3 9.9e-15 54.2 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EFA80174.1 - 0.00011 22.6 4.1 0.35 11.3 0.1 3.6 3 2 0 3 3 3 2 Cell division protein FtsA DUF4795 PF16043.5 EFA80174.1 - 0.0036 16.9 2.9 0.0036 16.9 2.9 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4795) DUF592 PF04574.13 EFA80174.1 - 0.0078 16.0 3.3 0.049 13.4 0.5 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF592) Zincin_2 PF10103.9 EFA80174.1 - 0.04 13.2 0.0 0.078 12.2 0.0 1.4 1 0 0 1 1 1 0 Zincin-like metallopeptidase Hydantoinase_A PF01968.18 EFA80174.1 - 0.087 12.1 0.5 1 8.6 0.1 2.5 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase StbA PF06406.11 EFA80174.1 - 0.098 11.9 2.1 0.13 11.5 0.0 2.1 2 0 0 2 2 2 0 StbA protein DUF1894 PF08979.11 EFA80174.1 - 0.11 12.9 0.0 0.94 9.9 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1894) Radial_spoke_3 PF06098.11 EFA80174.1 - 0.68 9.2 11.3 0.027 13.8 5.1 1.7 2 0 0 2 2 2 0 Radial spoke protein 3 Pex19 PF04614.12 EFA80174.1 - 1.6 8.5 11.7 0.49 10.1 5.2 2.4 2 0 0 2 2 2 0 Pex19 protein family zf-ZPR1 PF03367.13 EFA80174.1 - 9.4 6.1 6.7 1.9 8.3 1.6 2.3 2 0 0 2 2 2 0 ZPR1 zinc-finger domain Gelsolin PF00626.22 EFA80175.1 - 8.4e-30 102.5 2.5 6.1e-09 35.7 0.0 5.5 5 0 0 5 5 5 4 Gelsolin repeat PBD PF00786.28 EFA80175.1 - 2.3e-07 31.0 7.6 6.3e-06 26.5 0.1 4.0 3 1 0 3 3 3 2 P21-Rho-binding domain EGF_2 PF07974.13 EFA80176.1 - 0.009 16.4 13.1 0.017 15.5 13.1 1.5 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA80176.1 - 0.32 11.3 8.9 0.57 10.5 8.9 1.4 1 0 0 1 1 1 0 EGF-like domain Beta_helix PF13229.6 EFA80177.1 - 3.3e-05 23.8 10.1 3.3e-05 23.8 10.1 7.7 2 2 7 9 9 9 5 Right handed beta helix region Alba PF01918.21 EFA80179.1 - 2.6e-12 46.4 0.3 7.1e-12 45.0 0.1 1.9 2 0 0 2 2 2 1 Alba Rpp20 PF12328.8 EFA80179.1 - 2.2e-07 30.9 4.0 0.001 19.0 0.0 2.9 2 1 1 3 3 3 2 Rpp20 subunit of nuclear RNase MRP and P TPR_12 PF13424.6 EFA80180.1 - 7.4e-10 39.0 1.3 7.2e-08 32.6 1.8 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA80180.1 - 9.3e-08 31.6 1.7 0.0048 16.9 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA80180.1 - 8.6e-07 28.5 2.9 0.005 16.6 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFA80180.1 - 5.6e-05 22.5 0.3 0.00018 20.8 0.3 1.9 1 0 0 1 1 1 1 SHNi-TPR TPR_16 PF13432.6 EFA80180.1 - 0.00032 21.3 0.2 0.0006 20.4 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA80180.1 - 0.00062 19.8 5.6 0.32 11.3 0.3 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA80180.1 - 0.0021 17.7 1.3 0.049 13.3 0.6 2.6 2 0 0 2 2 2 1 TPR repeat ANAPC3 PF12895.7 EFA80180.1 - 0.0025 18.0 0.5 8.1 6.8 0.0 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 EFA80180.1 - 0.0039 16.9 0.2 0.0075 16.0 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_14 PF13428.6 EFA80180.1 - 0.17 12.8 0.4 9.5 7.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Rab15_effector PF15208.6 EFA80180.1 - 0.19 11.0 1.2 0.27 10.5 0.0 1.8 2 0 0 2 2 2 0 Rab15 effector Zip PF02535.22 EFA80180.1 - 0.27 10.4 2.6 0.45 9.7 2.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 EFA80180.1 - 9.1 5.5 11.0 17 4.6 11.0 1.5 1 0 0 1 1 1 0 NOA36 protein PIG-P PF08510.12 EFA80181.1 - 0.075 13.0 0.1 0.089 12.7 0.1 1.2 1 0 0 1 1 1 0 PIG-P Mid2 PF04478.12 EFA80181.1 - 1.8 8.4 9.6 0.29 11.0 2.5 2.0 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor ABC2_membrane_3 PF12698.7 EFA80182.1 - 4.8e-27 95.0 30.8 7.1e-27 94.4 30.8 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 EFA80182.1 - 5.5e-27 95.0 0.0 1e-26 94.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA80182.1 - 3.2e-13 50.2 0.5 7.5e-09 35.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA80182.1 - 0.0061 16.3 1.8 0.5 10.0 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain SMC_N PF02463.19 EFA80182.1 - 0.007 15.8 0.1 0.093 12.1 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 EFA80182.1 - 0.16 11.7 0.1 25 4.5 0.1 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein TMEM154 PF15102.6 EFA80182.1 - 0.19 11.7 1.5 0.22 11.4 0.2 1.8 2 0 0 2 2 2 0 TMEM154 protein family ABC2_membrane_3 PF12698.7 EFA80183.1 - 8.1e-29 100.8 47.1 2.6e-28 99.2 47.1 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 EFA80183.1 - 8.3e-22 78.2 0.0 1.9e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA80183.1 - 1.1e-08 35.2 0.1 6.2e-07 29.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA80183.1 - 0.0071 16.1 0.0 0.039 13.7 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain U62_UL91 PF17442.2 EFA80183.1 - 0.072 13.1 0.0 0.33 11.0 0.0 2.1 2 0 0 2 2 2 0 Functional domain of U62 and UL91 proteins SbcCD_C PF13558.6 EFA80183.1 - 0.096 12.9 0.0 0.34 11.2 0.0 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit CH PF00307.31 EFA80184.1 - 6.3e-15 55.3 0.1 2e-14 53.7 0.1 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA80184.1 - 0.0041 16.9 2.0 0.076 12.9 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain DUF3671 PF12420.8 EFA80184.1 - 0.011 15.8 3.7 0.032 14.3 3.7 1.8 1 0 0 1 1 1 0 Protein of unknown function SAPI PF16560.5 EFA80184.1 - 0.033 13.8 0.0 2.3 7.7 0.0 2.4 2 0 0 2 2 2 0 Putative mobile pathogenicity island RIFIN PF02009.16 EFA80184.1 - 0.047 13.6 4.8 0.079 12.8 4.8 1.3 1 0 0 1 1 1 0 Rifin DGF-1_C PF11040.8 EFA80184.1 - 1.1 9.3 5.7 1.5 8.8 1.6 3.1 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Aminotran_1_2 PF00155.21 EFA80185.1 - 1.6e-36 126.2 0.0 2.2e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cornichon PF03311.14 EFA80185.1 - 0.077 13.3 3.8 0.13 12.6 2.6 1.8 2 0 0 2 2 2 0 Cornichon protein Leo1 PF04004.13 EFA80186.1 - 7.4e-40 136.5 0.0 7.4e-40 136.5 0.0 3.2 3 0 0 3 3 3 1 Leo1-like protein PepSY_TM PF03929.16 EFA80187.1 - 0.00048 19.9 0.0 0.00051 19.8 0.0 1.3 1 0 0 1 1 1 1 PepSY-associated TM region EphA2_TM PF14575.6 EFA80187.1 - 0.019 15.8 0.1 0.073 14.0 0.0 2.0 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF202 PF02656.15 EFA80187.1 - 0.24 11.9 4.9 0.056 13.9 1.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF2273 PF10031.9 EFA80187.1 - 0.6 10.2 7.9 1.5 8.9 7.9 1.6 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) Peptidase_C1 PF00112.23 EFA80189.1 - 1.5e-47 162.5 1.6 1.5e-47 162.5 1.6 2.0 2 1 0 2 2 2 1 Papain family cysteine protease CAP PF00188.26 EFA80189.1 - 7.8e-10 39.7 6.2 1.9e-09 38.4 6.2 1.7 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Spermine_synth PF01564.17 EFA80190.1 - 0.023 14.1 1.6 0.45 9.9 0.6 2.0 1 1 1 2 2 2 0 Spermine/spermidine synthase domain DUF445 PF04286.12 EFA80191.1 - 0.012 15.5 1.6 0.02 14.7 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) HEAT_2 PF13646.6 EFA80191.1 - 0.092 13.1 0.1 39 4.7 0.0 3.4 3 0 0 3 3 3 0 HEAT repeats TIG PF01833.24 EFA80192.1 - 2e-53 178.4 68.9 1.5e-14 53.8 0.7 13.2 12 1 1 13 13 13 11 IPT/TIG domain DNase_II PF03265.15 EFA80192.1 - 5.3e-07 29.2 0.5 3.8e-06 26.4 0.0 2.4 2 0 0 2 2 2 1 Deoxyribonuclease II DNA_pol_B_3 PF08408.10 EFA80192.1 - 0.081 13.1 0.8 0.28 11.4 0.8 2.0 1 0 0 1 1 1 0 DNA polymerase family B viral insert tRNA-synt_1 PF00133.22 EFA80193.1 - 4.3e-56 190.4 6.2 7.7e-33 113.6 4.6 6.1 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EFA80193.1 - 2.8e-35 121.5 0.9 4.3e-35 120.9 0.0 1.8 2 0 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EFA80193.1 - 8.1e-29 100.5 5.6 9.2e-21 74.0 0.0 4.6 5 1 1 6 6 6 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFA80193.1 - 1.8e-13 50.7 0.6 4.3e-13 49.5 0.6 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFA80193.1 - 3.5e-06 26.6 0.2 0.025 13.9 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EFA80193.1 - 0.00054 19.0 0.1 0.18 10.7 0.0 3.4 3 0 0 3 3 3 1 tRNA synthetases class I (K) DUF4365 PF14280.6 EFA80193.1 - 0.019 14.9 0.6 0.047 13.6 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4365) Zn-ribbon_8 PF09723.10 EFA80193.1 - 0.24 11.6 1.4 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 EFA80193.1 - 3.9 7.0 6.8 3.8 7.0 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DUF2838 PF10998.8 EFA80194.1 - 3.8e-28 97.9 4.7 3.8e-28 97.9 4.7 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) Alpha-amylase PF00128.24 EFA80195.1 - 5.6e-83 279.3 0.0 1.4e-82 278.0 0.0 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EFA80195.1 - 0.052 11.7 0.0 0.1 10.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 VPS13_C PF16909.5 EFA80196.1 - 2e-58 197.1 12.4 1.8e-55 187.5 0.2 3.8 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 EFA80196.1 - 2e-44 152.0 19.9 8.8e-40 136.8 0.7 5.4 6 1 0 6 6 6 3 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 EFA80196.1 - 3.5e-37 128.4 1.7 3.5e-37 128.4 1.7 4.5 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EFA80196.1 - 2.1e-28 98.8 4.0 2.1e-28 98.8 4.0 4.1 2 2 0 2 2 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EFA80196.1 - 7.1e-09 35.9 0.1 3.5e-08 33.7 0.1 2.2 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain TIG PF01833.24 EFA80196.1 - 1e-07 32.0 1.3 1e-07 32.0 1.3 3.4 3 0 0 3 3 2 1 IPT/TIG domain EGF PF00008.27 EFA80196.1 - 0.00095 19.4 8.1 0.0023 18.2 8.1 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 EFA80196.1 - 0.0077 16.6 8.7 0.015 15.7 8.7 1.4 1 0 0 1 1 1 1 EGF-like domain PRIMA1 PF16101.5 EFA80196.1 - 0.069 13.2 0.1 0.21 11.6 0.1 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 hEGF PF12661.7 EFA80196.1 - 0.23 12.2 8.0 0.51 11.1 8.0 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF DUF4778 PF16008.5 EFA80196.1 - 1.9 8.5 18.6 0.31 11.1 9.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4778) Cnd2 PF05786.14 EFA80197.1 - 1.3e-145 487.0 50.9 1.3e-145 487.0 50.9 1.7 1 1 1 2 2 2 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EFA80197.1 - 6.2e-06 26.4 0.1 6.2e-06 26.4 0.1 4.8 4 2 1 5 5 5 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal BLOC1S3 PF15753.5 EFA80198.1 - 6.2e-06 26.4 26.8 3e-05 24.2 14.4 2.7 1 1 2 3 3 3 2 Biogenesis of lysosome-related organelles complex 1 subunit 3 GREB1 PF15782.5 EFA80198.1 - 0.64 7.1 22.2 0.76 6.8 22.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 EFA80198.1 - 0.78 8.2 30.0 1.1 7.7 30.0 1.3 1 0 0 1 1 1 0 Macoilin family GP67 PF17634.2 EFA80198.1 - 2.9 8.4 10.6 0.17 12.3 5.1 1.7 2 0 0 2 2 2 0 Gene product 67 CH PF00307.31 EFA80199.1 - 1.6e-34 118.4 12.4 1e-18 67.5 0.0 4.6 4 0 0 4 4 4 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA80199.1 - 0.0033 17.2 1.2 0.017 15.0 0.0 2.7 3 0 0 3 3 3 1 CAMSAP CH domain Kelch_6 PF13964.6 EFA80200.1 - 4e-45 150.7 5.7 1.8e-09 37.5 0.0 6.4 4 1 2 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EFA80200.1 - 6.1e-41 137.8 4.6 7.7e-10 38.2 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFA80200.1 - 4.5e-36 122.6 11.1 1.8e-08 34.3 0.1 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA80200.1 - 2.6e-34 115.9 10.9 7.6e-10 38.4 0.1 7.3 7 1 0 7 7 7 6 Kelch motif Kelch_5 PF13854.6 EFA80200.1 - 1.5e-31 107.8 4.0 2.5e-05 24.1 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFA80200.1 - 1.5e-27 95.2 10.6 1.2e-08 35.0 0.0 7.9 8 0 0 8 8 8 4 Galactose oxidase, central domain F-box-like PF12937.7 EFA80200.1 - 0.0034 17.2 0.0 0.0097 15.8 0.0 1.8 1 0 0 1 1 1 1 F-box-like Orn_Arg_deC_N PF02784.16 EFA80202.1 - 6.1e-41 140.4 0.1 7.6e-41 140.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFA80202.1 - 1.5e-10 41.2 0.0 4.6e-10 39.6 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain HEXIM PF15313.6 EFA80203.1 - 0.00072 19.8 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Hexamethylene bis-acetamide-inducible protein TPR_2 PF07719.17 EFA80204.1 - 1.9e-07 30.7 10.0 0.018 15.1 0.4 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA80204.1 - 5.3e-07 29.2 6.9 1.2e-05 24.9 0.2 4.1 2 1 2 4 4 4 1 TPR repeat TPR_1 PF00515.28 EFA80204.1 - 9.8e-07 28.3 11.3 0.0009 19.0 0.7 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF3856 PF12968.7 EFA80204.1 - 2.1e-05 24.6 0.3 0.00023 21.2 0.3 2.2 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) SET PF00856.28 EFA80204.1 - 6.1e-05 23.5 7.2 0.00019 21.9 7.2 2.1 1 1 0 1 1 1 1 SET domain TPR_8 PF13181.6 EFA80204.1 - 0.0052 16.9 10.6 0.95 9.8 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA80204.1 - 0.021 15.1 3.1 2.7 8.4 0.8 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat RNase_P_Rpp14 PF01900.19 EFA80204.1 - 0.064 13.5 0.1 0.34 11.2 0.0 2.3 2 0 0 2 2 2 0 Rpp14/Pop5 family TPR_9 PF13371.6 EFA80204.1 - 0.085 13.0 0.2 0.76 10.0 0.0 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFA80204.1 - 0.17 12.5 0.3 13 6.6 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA80204.1 - 0.38 11.2 14.3 0.52 10.8 0.2 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 EFA80204.1 - 1.8 8.7 4.7 8.8 6.5 0.1 3.0 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain AMP-binding PF00501.28 EFA80205.1 - 2.2e-73 247.3 0.0 1.3e-40 139.3 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFA80205.1 - 6.9e-20 71.8 0.0 1.4e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Retrotrans_gag PF03732.17 EFA80205.1 - 4.7 7.6 7.3 20 5.5 0.3 2.9 3 0 0 3 3 3 0 Retrotransposon gag protein DUF1771 PF08590.10 EFA80206.1 - 8.1e-14 51.7 9.2 8.1e-14 51.7 9.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) KH_1 PF00013.29 EFA80206.1 - 9.4e-14 51.0 1.3 2.3e-13 49.7 1.3 1.7 1 0 0 1 1 1 1 KH domain Smr PF01713.21 EFA80206.1 - 2.8e-07 30.8 0.0 8.6e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Smr domain AAA_11 PF13086.6 EFA80206.1 - 7.6e-05 22.6 6.0 0.0001 22.2 6.0 1.2 1 0 0 1 1 1 1 AAA domain T5orf172 PF10544.9 EFA80206.1 - 0.0086 16.6 3.6 1.5 9.4 0.0 2.8 3 1 0 3 3 3 1 T5orf172 domain KH_2 PF07650.17 EFA80206.1 - 0.13 12.2 1.4 0.25 11.2 0.2 2.1 2 0 0 2 2 2 0 KH domain Asp4 PF16996.5 EFA80206.1 - 0.17 11.7 0.0 0.48 10.2 0.0 1.7 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 TFIIA PF03153.13 EFA80206.1 - 0.52 10.3 18.3 0.62 10.0 18.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RPA_C PF08784.11 EFA80206.1 - 0.75 10.5 5.1 1.8 9.2 3.3 2.7 2 1 0 2 2 2 0 Replication protein A C terminal DUF2040 PF09745.9 EFA80207.1 - 4.3e-35 120.4 19.8 4.3e-35 120.4 19.8 3.0 3 1 0 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) Methyltransf_11 PF08241.12 EFA80208.1 - 1.6e-19 70.4 0.0 2.6e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA80208.1 - 8.4e-18 64.9 0.0 1.4e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA80208.1 - 4.2e-17 62.3 0.0 5.8e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA80208.1 - 3.6e-15 56.2 0.0 5.5e-15 55.6 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA80208.1 - 1.4e-12 48.2 0.0 2.2e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA80208.1 - 3.4e-11 42.9 0.0 5.2e-11 42.3 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 EFA80208.1 - 0.0029 17.0 0.0 0.0043 16.5 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB TPMT PF05724.11 EFA80208.1 - 0.0065 16.2 0.0 0.012 15.2 0.0 1.5 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_32 PF13679.6 EFA80208.1 - 0.024 14.6 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EFA80208.1 - 0.035 13.7 0.0 0.091 12.4 0.0 1.5 2 0 0 2 2 2 0 Nodulation protein S (NodS) CMAS PF02353.20 EFA80208.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FNIP PF05725.12 EFA80209.1 - 7.5e-09 35.6 0.2 7.5e-09 35.6 0.2 2.9 4 1 0 4 4 4 1 FNIP Repeat Phage_antitermQ PF06530.12 EFA80209.1 - 0.008 16.1 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Phage antitermination protein Q BrkDBD PF09607.10 EFA80209.1 - 0.046 13.5 0.1 0.086 12.6 0.1 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain Peptidase_M49 PF03571.15 EFA80210.1 - 4.3e-227 754.9 0.1 6.5e-227 754.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M49 2C_adapt PF08793.10 EFA80210.1 - 0.015 15.4 0.1 0.034 14.3 0.1 1.5 1 0 0 1 1 1 0 2-cysteine adaptor domain 5_nucleotid_C PF02872.18 EFA80210.1 - 0.027 14.7 0.3 0.11 12.7 0.2 2.0 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain Mpv17_PMP22 PF04117.12 EFA80211.1 - 3.3e-16 59.3 2.3 9.1e-16 57.8 2.3 1.8 1 0 0 1 1 1 1 Mpv17 / PMP22 family DALR_1 PF05746.15 EFA80211.1 - 0.0071 16.5 0.8 0.031 14.4 0.0 2.6 2 0 0 2 2 2 1 DALR anticodon binding domain Ipi1_N PF12333.8 EFA80211.1 - 0.53 10.9 5.8 7 7.3 0.5 3.8 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation DUF2722 PF10846.8 EFA80211.1 - 1.2 8.0 25.5 0.0073 15.3 15.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Mit_ribos_Mrp51 PF11709.8 EFA80211.1 - 1.7 8.2 12.4 0.22 11.1 8.2 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit Activator_LAG-3 PF11498.8 EFA80211.1 - 1.8 7.4 21.5 2.9 6.8 21.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 GDP_Man_Dehyd PF16363.5 EFA80212.1 - 1.8e-55 188.7 0.0 2.2e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA80212.1 - 3.3e-48 164.2 0.0 4e-48 164.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA80212.1 - 3.5e-15 55.8 0.1 9.5e-14 51.1 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFA80212.1 - 3e-14 52.9 0.0 6.1e-14 51.8 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EFA80212.1 - 3.5e-09 36.8 0.1 6e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EFA80212.1 - 7.4e-09 35.1 0.0 1.1e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EFA80212.1 - 2.6e-08 33.6 0.1 4.6e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EFA80212.1 - 3.5e-05 23.1 0.1 0.001 18.3 0.0 2.4 1 1 1 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 EFA80212.1 - 0.00018 21.5 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GUN4 PF05419.12 EFA80212.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 GUN4-like DUF1932 PF09130.11 EFA80212.1 - 0.19 11.7 0.0 2.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1932) MMR_HSR1_Xtn PF16897.5 EFA80213.1 - 1.7e-43 146.9 0.3 4.3e-43 145.7 0.3 1.7 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EFA80213.1 - 3.5e-21 75.0 0.1 7.1e-21 74.0 0.1 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EFA80213.1 - 7.2e-21 74.4 0.0 1.7e-20 73.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA80213.1 - 7.6e-11 41.8 0.0 1.6e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFA80213.1 - 0.0015 18.6 0.2 1.9 8.5 0.0 2.6 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EFA80213.1 - 0.0079 15.2 0.1 0.017 14.1 0.1 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB WD40 PF00400.32 EFA80214.1 - 1.3e-45 152.5 26.0 0.00016 22.4 0.1 11.8 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80214.1 - 4.1e-19 68.7 6.3 1.3e-05 25.4 0.0 8.0 4 3 4 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EFA80214.1 - 1.1e-15 57.9 0.1 2.5e-15 56.7 0.1 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 EFA80214.1 - 5.6e-10 39.0 0.4 0.0042 16.5 0.0 4.2 3 2 1 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 EFA80214.1 - 1.4e-07 30.8 11.5 0.056 12.4 0.0 6.9 3 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EFA80214.1 - 0.0067 15.4 3.2 0.83 8.5 0.0 4.3 4 1 1 5 5 5 1 Partner and localizer of BRCA2 WD40 domain ELYS-bb PF16687.5 EFA80214.1 - 0.018 13.7 0.0 5.3 5.5 0.0 2.8 3 0 0 3 3 3 0 beta-propeller of ELYS nucleoporin Nbas_N PF15492.6 EFA80214.1 - 0.067 12.5 0.8 0.84 8.9 0.0 3.0 5 0 0 5 5 5 0 Neuroblastoma-amplified sequence, N terminal UTP15_C PF09384.10 EFA80214.1 - 0.069 12.8 1.1 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 UTP15 C terminal DUF1410 PF07198.11 EFA80215.1 - 0.033 14.7 1.0 0.15 12.6 1.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1410) SKA1 PF07160.12 EFA80216.1 - 0.027 14.3 6.7 0.043 13.7 6.7 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DDHD PF02862.17 EFA80216.1 - 0.047 13.8 5.7 0.056 13.6 5.7 1.2 1 0 0 1 1 1 0 DDHD domain P2 PF07194.11 EFA80216.1 - 0.051 13.6 0.4 5.1 7.2 0.0 2.5 2 0 0 2 2 2 0 P2 response regulator binding domain Med9 PF07544.13 EFA80216.1 - 0.053 13.6 1.8 0.24 11.5 1.8 2.1 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF16 PF01519.16 EFA80216.1 - 0.1 13.1 4.5 0.098 13.2 1.5 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Sporozoite_P67 PF05642.11 EFA80216.1 - 0.34 9.0 11.3 0.44 8.6 11.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ADIP PF11559.8 EFA80216.1 - 0.54 10.3 14.8 0.18 11.9 1.7 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Zip PF02535.22 EFA80216.1 - 0.72 9.0 5.2 0.84 8.8 5.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 EFA80216.1 - 0.96 8.2 7.1 1.1 8.1 7.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SOGA PF11365.8 EFA80216.1 - 1.2 10.3 9.8 7.3 7.8 0.1 3.0 2 1 1 3 3 3 0 Protein SOGA Presenilin PF01080.17 EFA80216.1 - 7.5 5.2 9.7 9.5 4.9 9.7 1.1 1 0 0 1 1 1 0 Presenilin Kelch_6 PF13964.6 EFA80217.1 - 1e-12 47.9 6.8 1.3e-05 25.3 0.2 5.0 4 1 1 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA80217.1 - 2.9e-06 27.3 9.8 8.1e-06 25.9 9.8 1.8 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA80217.1 - 6.2e-05 23.2 8.1 0.00025 21.3 0.1 5.1 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA80217.1 - 0.00017 21.5 4.9 0.84 9.7 0.1 4.3 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA80217.1 - 0.00042 20.2 3.6 2.9 8.0 0.2 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFA80217.1 - 0.00048 19.6 7.9 0.0025 17.4 0.7 4.4 5 1 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 EFA80217.1 - 0.013 15.4 3.7 0.094 12.7 0.4 3.3 3 0 0 3 3 3 0 Kelch motif SR-25 PF10500.9 EFA80217.1 - 0.46 10.0 26.2 0.39 10.3 6.8 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-UBR PF02207.20 EFA80217.1 - 1.9 8.7 12.5 0.44 10.7 6.3 2.6 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) DUF525 PF04379.14 EFA80218.1 - 1.3e-19 70.2 0.0 2.3e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 ApaG domain SMI1_KNR4 PF09346.10 EFA80218.1 - 4.5e-06 27.1 0.3 9.4e-06 26.1 0.3 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) F-box PF00646.33 EFA80218.1 - 0.0009 19.1 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFA80218.1 - 0.0035 17.2 0.1 0.0077 16.1 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80218.1 - 0.038 13.9 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 F-box-like SUKH_6 PF14568.6 EFA80218.1 - 0.14 12.5 2.1 1.3 9.5 0.9 2.6 2 1 0 2 2 2 0 SMI1-KNR4 cell-wall WRKY PF03106.15 EFA80219.1 - 1e-41 140.9 18.0 1.4e-23 82.9 6.0 4.6 4 0 0 4 4 4 2 WRKY DNA -binding domain PH PF00169.29 EFA80220.1 - 4.5e-06 27.1 2.4 1.4e-05 25.6 0.0 2.8 3 0 0 3 3 3 1 PH domain PH_13 PF16652.5 EFA80220.1 - 0.039 13.8 2.2 0.093 12.5 0.1 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain PH_6 PF15406.6 EFA80220.1 - 0.11 12.8 0.0 0.39 11.0 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain WAP PF00095.21 EFA80221.1 - 0.019 15.3 13.4 0.028 14.8 13.4 1.2 1 0 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Conotoxin PF02950.17 EFA80221.1 - 0.043 14.8 7.6 0.086 13.9 7.6 1.5 1 1 0 1 1 1 0 Conotoxin Defensin_beta_2 PF13841.6 EFA80221.1 - 0.86 10.2 9.6 2.2 8.9 5.5 3.0 2 1 0 2 2 2 0 Beta defensin Pkinase PF00069.25 EFA80222.1 - 1.7e-44 152.2 15.9 1.4e-22 80.3 0.0 4.6 5 0 0 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80222.1 - 2.5e-23 82.7 0.0 2.8e-11 43.2 0.0 4.0 3 0 0 3 3 3 3 Protein tyrosine kinase tRNA-synt_His PF13393.6 EFA80222.1 - 1.4e-16 60.7 0.0 3.9e-15 55.9 0.0 2.5 2 0 0 2 2 2 1 Histidyl-tRNA synthetase RWD PF05773.22 EFA80222.1 - 3.2e-15 56.4 0.0 3.2e-15 56.4 0.0 3.1 4 0 0 4 4 4 1 RWD domain HGTP_anticodon2 PF12745.7 EFA80222.1 - 5.7e-14 52.3 0.1 5.7e-14 52.3 0.1 6.2 8 0 0 8 8 8 1 Anticodon binding domain of tRNAs HGTP_anticodon PF03129.20 EFA80222.1 - 2.1e-07 31.0 0.2 3.7e-06 27.0 0.1 2.7 2 0 0 2 2 2 1 Anticodon binding domain Kinase-like PF14531.6 EFA80222.1 - 0.002 17.5 0.1 0.012 14.9 0.0 2.4 3 0 0 3 3 3 1 Kinase-like Exog_C PF18026.1 EFA80222.1 - 0.072 13.1 0.1 0.84 9.7 0.0 2.8 3 0 0 3 3 3 0 Endo/exonuclease (EXOG) C-terminal domain RhoGAP PF00620.27 EFA80222.1 - 0.12 12.2 2.5 2.6 7.9 0.4 3.4 3 0 0 3 3 3 0 RhoGAP domain GATA PF00320.27 EFA80223.1 - 7.5e-13 47.8 4.1 1.6e-12 46.8 4.1 1.6 1 0 0 1 1 1 1 GATA zinc finger Menin PF05053.13 EFA80223.1 - 0.12 10.7 7.3 0.25 9.7 7.3 1.5 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 EFA80223.1 - 0.17 10.1 9.2 0.24 9.6 9.2 1.3 1 0 0 1 1 1 0 CDC45-like protein AT_hook PF02178.19 EFA80223.1 - 1.2 9.2 5.4 3.6 7.8 5.4 1.9 1 0 0 1 1 1 0 AT hook motif OMPdecase PF00215.24 EFA80224.1 - 1.5e-74 250.4 0.1 2.5e-74 249.7 0.1 1.4 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 EFA80224.1 - 3.5e-12 46.1 0.1 6.5e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF3439 PF11921.8 EFA80225.1 - 4.7 7.2 9.9 2.9 7.9 2.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) GST_N_3 PF13417.6 EFA80226.1 - 9.8e-09 35.5 0.0 1.7e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA80226.1 - 3.5e-06 27.2 0.0 5.8e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFA80226.1 - 1.2e-05 25.5 0.0 3.4e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA80226.1 - 0.0042 17.3 0.1 0.007 16.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA80226.1 - 0.011 16.0 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF202 PF02656.15 EFA80227.1 - 3.3e-18 65.9 1.8 3.3e-18 65.9 1.8 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF202) LMBR1 PF04791.16 EFA80227.1 - 0.21 10.5 3.9 0.34 9.8 3.9 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein SPX PF03105.19 EFA80227.1 - 0.23 11.3 15.2 0.3 10.9 15.2 1.0 1 0 0 1 1 1 0 SPX domain ATP-synt_C PF00137.21 EFA80227.1 - 0.24 11.8 6.0 0.64 10.4 6.0 1.7 1 1 0 1 1 1 0 ATP synthase subunit C LAP1C PF05609.12 EFA80227.1 - 0.49 9.4 7.1 0.56 9.2 7.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dicty_REP PF05086.12 EFA80227.1 - 2.8 5.8 17.9 3.8 5.4 17.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Macoilin PF09726.9 EFA80227.1 - 4.7 5.6 20.8 5.5 5.4 20.8 1.1 1 0 0 1 1 1 0 Macoilin family WD40 PF00400.32 EFA80228.1 - 2.4e-56 186.4 21.2 4e-09 36.9 0.7 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80228.1 - 3.3e-13 49.7 0.4 0.033 14.5 0.0 4.8 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA80228.1 - 1.6e-05 23.8 2.5 0.31 9.6 0.0 3.6 2 2 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EFA80228.1 - 0.0002 20.8 0.0 0.16 11.3 0.0 2.7 1 1 2 3 3 3 2 WD40-like domain DUF1513 PF07433.11 EFA80228.1 - 0.016 14.3 0.0 3.3 6.7 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) PD40 PF07676.12 EFA80228.1 - 0.095 12.7 0.1 44 4.2 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat GDPD PF03009.17 EFA80230.1 - 0.028 14.2 2.0 0.033 13.9 2.0 1.0 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family RE_TaqI PF09573.10 EFA80231.1 - 0.011 15.5 1.2 0.014 15.2 0.2 1.6 1 1 1 2 2 2 0 TaqI restriction endonuclease OspE PF02471.17 EFA80231.1 - 0.079 13.2 2.9 0.12 12.6 1.2 2.1 1 1 1 2 2 2 0 Borrelia outer surface protein E SNF2_N PF00176.23 EFA80232.1 - 8.3e-75 251.7 0.0 8.3e-75 251.7 0.0 2.4 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA80232.1 - 1.1e-18 67.5 1.2 2.7e-18 66.3 0.0 2.5 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 EFA80232.1 - 1.4e-08 34.6 1.7 1.4e-08 34.6 1.7 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFA80232.1 - 4.1e-08 32.9 3.7 4.1e-08 32.9 3.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA80232.1 - 2.8e-07 30.3 4.5 2.8e-07 30.3 4.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA80232.1 - 7.4e-06 25.7 2.2 7.4e-06 25.7 2.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA80232.1 - 2.3e-05 24.2 2.5 2.3e-05 24.2 2.5 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA80232.1 - 0.00011 22.5 3.1 0.00011 22.5 3.1 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFA80232.1 - 0.00011 22.2 3.4 0.00011 22.2 3.4 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFA80232.1 - 0.00042 20.1 2.0 0.00042 20.1 2.0 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EFA80232.1 - 0.0065 16.3 0.4 0.024 14.5 0.4 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit HIRAN PF08797.11 EFA80232.1 - 0.0071 16.3 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 HIRAN domain PIEZO PF15917.5 EFA80232.1 - 0.34 10.4 12.9 1.2 8.6 12.9 2.0 1 0 0 1 1 1 0 Piezo zf-rbx1 PF12678.7 EFA80232.1 - 2.1 8.7 7.6 0.09 13.1 0.4 2.6 3 0 0 3 3 1 0 RING-H2 zinc finger domain RhoGAP PF00620.27 EFA80233.1 - 3.3e-33 114.7 2.2 1e-32 113.0 0.1 2.6 2 0 0 2 2 2 1 RhoGAP domain Kelch_3 PF13415.6 EFA80233.1 - 1.9e-21 75.8 11.8 2.2e-10 40.6 0.1 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EFA80233.1 - 4.8e-21 74.5 12.4 4.3e-08 33.0 0.1 5.2 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA80233.1 - 7.2e-20 70.1 6.2 4.3e-06 26.5 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EFA80233.1 - 3.1e-19 68.5 4.1 2.6e-07 30.7 0.3 5.0 3 1 1 4 4 4 4 Kelch motif Kelch_5 PF13854.6 EFA80233.1 - 1.2e-14 53.9 8.4 2.3e-07 30.6 0.8 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EFA80233.1 - 1.8e-11 43.4 11.3 3.9e-06 26.3 0.1 4.2 5 0 0 5 5 5 2 Kelch motif RhoGAP PF00620.27 EFA80234.1 - 7e-36 123.3 1.7 7e-36 123.3 1.7 3.0 3 0 0 3 3 3 1 RhoGAP domain BAR_3 PF16746.5 EFA80234.1 - 0.12 12.0 15.1 1.1 8.9 12.3 3.5 2 1 0 2 2 2 0 BAR domain of APPL family RusA PF05866.11 EFA80234.1 - 0.24 12.0 3.8 0.87 10.1 0.2 3.0 2 1 1 3 3 3 0 Endodeoxyribonuclease RusA DUF1840 PF08895.11 EFA80234.1 - 0.6 10.5 4.7 4.8 7.6 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1840) zf-ZPR1 PF03367.13 EFA80235.1 - 7.2e-109 360.7 7.2 3.2e-54 183.1 0.2 2.4 3 0 0 3 3 3 2 ZPR1 zinc-finger domain HypA PF01155.19 EFA80235.1 - 0.011 15.8 0.6 0.81 9.7 0.1 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrom_NNT PF03264.14 EFA80235.1 - 0.022 14.5 1.7 0.024 14.3 0.0 1.9 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Zn-ribbon_8 PF09723.10 EFA80235.1 - 2.1 8.6 4.9 24 5.2 0.0 3.5 4 0 0 4 4 4 0 Zinc ribbon domain 3Beta_HSD PF01073.19 EFA80236.1 - 6.2e-75 251.8 0.0 8.1e-75 251.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFA80236.1 - 6.9e-37 127.2 0.0 9.4e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFA80236.1 - 1.4e-19 70.7 0.0 1.2e-16 61.0 0.0 2.5 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFA80236.1 - 1.2e-16 60.7 0.0 1e-11 44.5 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EFA80236.1 - 7.5e-15 55.3 0.0 1.3e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFA80236.1 - 5.5e-11 42.1 0.0 6.6e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFA80236.1 - 3.2e-09 36.3 0.0 9.1e-09 34.9 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EFA80236.1 - 5.8e-06 26.0 0.0 1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EFA80236.1 - 3.2e-05 23.9 0.0 0.22 11.4 0.0 2.3 2 0 0 2 2 2 2 KR domain Sacchrp_dh_NADP PF03435.18 EFA80236.1 - 0.012 15.8 0.1 0.029 14.7 0.1 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GlcNAc PF11397.8 EFA80237.1 - 6.8e-69 233.0 1.1 4.7e-67 226.9 0.1 2.2 1 1 1 2 2 2 2 Glycosyltransferase (GlcNAc) Fip1 PF05182.13 EFA80237.1 - 1.1e-22 79.2 2.8 2.8e-22 77.9 2.8 1.7 1 0 0 1 1 1 1 Fip1 motif Ribosomal_L21p PF00829.21 EFA80238.1 - 7.5e-31 106.4 0.9 9.9e-31 106.0 0.9 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein adh_short PF00106.25 EFA80239.1 - 2e-42 144.9 0.0 2.5e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA80239.1 - 2.2e-27 96.1 0.0 2.6e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA80239.1 - 2.6e-08 34.0 0.0 3.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFA80239.1 - 2.8e-05 23.7 0.1 0.00036 20.0 0.1 2.0 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Sacchrp_dh_NADP PF03435.18 EFA80239.1 - 0.00052 20.3 0.1 0.0018 18.6 0.0 1.9 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFA80239.1 - 0.0092 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Adenylsucc_synt PF00709.21 EFA80239.1 - 0.013 14.4 0.0 0.018 14.0 0.0 1.1 1 0 0 1 1 1 0 Adenylosuccinate synthetase 3HCDH_N PF02737.18 EFA80239.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFA80239.1 - 0.018 14.2 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFA80239.1 - 0.027 13.9 0.1 0.056 12.9 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TMEM126 PF07114.11 EFA80239.1 - 0.09 12.2 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 126 ApbA PF02558.16 EFA80239.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Med21 PF11221.8 EFA80240.1 - 8.2e-18 65.0 3.7 1.1e-16 61.4 3.7 1.9 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF2935 PF11155.8 EFA80240.1 - 0.085 13.2 0.3 0.11 12.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) zf-Nse PF11789.8 EFA80241.1 - 1.4e-21 76.1 1.5 3.6e-21 74.7 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EFA80241.1 - 3.6e-09 36.5 2.8 4.9e-09 36.1 0.5 2.4 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFA80241.1 - 6.1e-05 22.8 0.3 0.00016 21.4 0.2 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 EFA80241.1 - 0.0004 20.1 0.9 0.00088 19.0 0.9 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.25 EFA80241.1 - 0.0016 18.3 1.6 0.0021 17.9 0.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EFA80241.1 - 0.0021 17.5 1.1 0.0021 17.5 1.1 1.6 1 1 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EFA80241.1 - 0.009 16.1 1.5 0.013 15.6 0.4 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFA80241.1 - 0.012 15.9 0.8 0.03 14.7 0.8 1.7 1 0 0 1 1 1 0 Ring finger domain IML1 PF12257.8 EFA80241.1 - 0.026 13.6 0.5 0.042 13.0 0.5 1.4 1 0 0 1 1 1 0 Vacuolar membrane-associated protein Iml1 zf-rbx1 PF12678.7 EFA80241.1 - 0.05 13.9 0.5 0.13 12.5 0.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Sec34 PF04136.15 EFA80241.1 - 0.066 13.1 0.3 0.066 13.1 0.3 2.3 1 1 1 2 2 2 0 Sec34-like family DAGK_cat PF00781.24 EFA80242.1 - 1.7e-25 89.1 0.0 2.6e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 EFA80242.1 - 0.001 18.3 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase PFK PF00365.20 EFA80242.1 - 0.0086 15.4 0.4 0.016 14.5 0.1 1.5 2 0 0 2 2 2 1 Phosphofructokinase Syja_N PF02383.18 EFA80244.1 - 5.5e-45 154.1 0.0 1.1e-44 153.1 0.0 1.5 1 0 0 1 1 1 1 SacI homology domain Pro-kuma_activ PF09286.11 EFA80244.1 - 9.1e-07 29.3 0.4 2.8e-05 24.4 0.2 2.7 1 1 1 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFA80244.1 - 1.3e-06 27.9 1.7 2.7e-06 26.9 1.7 1.4 1 0 0 1 1 1 1 Subtilase family Nup88 PF10168.9 EFA80245.1 - 0.015 13.2 6.8 0.017 12.9 6.8 1.1 1 0 0 1 1 1 0 Nuclear pore component QueC PF06508.13 EFA80245.1 - 0.049 13.1 1.8 0.08 12.4 1.8 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC DUF4407 PF14362.6 EFA80245.1 - 1.4 8.2 10.0 1.9 7.8 10.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ETRAMP PF09716.10 EFA80245.1 - 7.2 6.7 7.4 56 3.9 7.4 2.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Siva PF05458.12 EFA80246.1 - 0.45 10.2 29.8 1 9.0 26.0 2.1 1 1 1 2 2 2 0 Cd27 binding protein (Siva) Peptidase_S28 PF05577.12 EFA80247.1 - 3.6e-84 283.1 0.1 5.1e-84 282.6 0.1 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EFA80247.1 - 0.0037 17.0 0.2 0.0097 15.6 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA80247.1 - 0.0048 17.5 0.2 0.015 15.9 0.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFA80247.1 - 0.0056 16.2 0.0 0.013 14.9 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S37 PF05576.11 EFA80247.1 - 0.0089 14.7 0.0 0.026 13.2 0.0 1.7 2 1 0 2 2 2 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 EFA80247.1 - 0.052 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2920 PF11144.8 EFA80247.1 - 0.15 11.2 0.0 0.29 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) DNA_pol3_beta PF00712.19 EFA80248.1 - 0.84 9.8 4.8 2.6 8.2 0.4 2.9 2 1 1 3 3 3 0 DNA polymerase III beta subunit, N-terminal domain Methyltransf_16 PF10294.9 EFA80249.1 - 1.5e-24 86.7 0.1 2.2e-24 86.1 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFA80249.1 - 6.8e-06 26.0 0.0 9.1e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA80249.1 - 0.00055 20.6 0.0 0.00092 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA80249.1 - 0.0018 18.9 0.0 0.0034 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA80249.1 - 0.0067 16.2 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA80249.1 - 0.013 16.2 0.0 0.028 15.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EFA80249.1 - 0.016 14.9 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 EFA80249.1 - 0.033 13.7 0.0 0.055 13.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Cons_hypoth95 PF03602.15 EFA80249.1 - 0.097 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DUF938 PF06080.12 EFA80249.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) BolA PF01722.18 EFA80250.1 - 4e-29 100.7 0.6 5.2e-29 100.3 0.6 1.2 1 0 0 1 1 1 1 BolA-like protein NTP_transf_6 PF06042.11 EFA80250.1 - 0.14 12.0 0.1 0.35 10.7 0.0 1.6 1 1 1 2 2 2 0 Nucleotidyltransferase DnaJ_C PF01556.18 EFA80251.1 - 1.4e-40 138.8 0.3 2e-40 138.3 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFA80251.1 - 5.8e-24 84.0 1.9 1e-23 83.2 1.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFA80251.1 - 1.1e-11 44.9 18.7 1.1e-11 44.9 18.7 2.3 2 0 0 2 2 2 1 DnaJ central domain zf-RING_10 PF16685.5 EFA80251.1 - 0.0091 16.1 0.4 0.0091 16.1 0.4 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 Anti-TRAP PF15777.5 EFA80251.1 - 0.29 11.1 19.6 1.1 9.3 4.9 2.9 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 EFA80251.1 - 2.1 8.6 22.9 2.7 8.2 1.0 4.8 4 0 0 4 4 4 0 Family of unknown function (DUF5351) Lactamase_B PF00753.27 EFA80252.1 - 0.0077 16.3 6.7 0.076 13.0 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily SelP_N PF04592.14 EFA80252.1 - 1.9 7.8 23.7 2.2 7.6 23.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CPSF73-100_C PF11718.8 EFA80253.1 - 1.4e-59 201.3 4.5 2.7e-59 200.3 4.5 1.5 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EFA80253.1 - 1.9e-31 108.6 0.1 1.6e-30 105.6 0.0 2.4 2 1 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 EFA80253.1 - 2e-15 56.5 0.1 6.2e-15 54.9 0.1 1.9 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EFA80253.1 - 3e-12 46.4 0.2 1.4e-11 44.2 0.0 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EFA80253.1 - 3.9e-06 26.2 0.1 9.6e-06 25.0 0.1 1.7 1 0 0 1 1 1 1 Putative beta-lactamase-like family OGG_N PF07934.12 EFA80253.1 - 0.11 12.6 0.2 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain Cyclin PF08613.11 EFA80254.1 - 1.7e-06 28.5 1.2 1.7e-06 28.5 1.2 3.8 2 2 0 2 2 2 1 Cyclin Methyltransf_3 PF01596.17 EFA80255.1 - 8.8e-65 217.8 0.2 1.1e-64 217.5 0.2 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EFA80255.1 - 1.2e-13 51.9 0.0 1.9e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA80255.1 - 0.00029 20.6 0.2 0.00036 20.3 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA80255.1 - 0.0004 21.0 0.0 0.0013 19.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFA80255.1 - 0.007 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA80255.1 - 0.012 14.9 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SpoIIE PF07228.12 EFA80256.1 - 0.13 12.1 0.4 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) HLH PF00010.26 EFA80257.1 - 0.69 9.9 3.9 0.52 10.3 1.1 2.3 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain NADH_dhqG_C PF09326.11 EFA80257.1 - 3.7 8.3 5.5 0.82 10.4 0.1 2.9 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal GFO_IDH_MocA PF01408.22 EFA80258.1 - 2e-21 77.1 0.0 3.4e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFA80258.1 - 6.8e-08 32.5 0.0 1.6e-07 31.3 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EFA80258.1 - 0.076 13.7 0.0 0.15 12.7 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain PC4 PF02229.16 EFA80259.1 - 1.9e-14 53.0 0.1 3.9e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) PepSY_TM PF03929.16 EFA80259.1 - 0.021 14.5 0.7 0.026 14.2 0.7 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Ndc1_Nup PF09531.10 EFA80259.1 - 0.061 12.0 8.0 0.059 12.1 8.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF5069 PF16798.5 EFA80259.1 - 0.08 13.1 5.9 0.15 12.3 4.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5069) DUF1892 PF08987.10 EFA80259.1 - 0.11 12.7 0.2 0.11 12.7 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1892) G0-G1_switch_2 PF15103.6 EFA80259.1 - 0.12 12.8 3.9 0.26 11.7 3.9 1.6 1 0 0 1 1 1 0 G0/G1 switch protein 2 Ureide_permease PF07168.11 EFA80259.1 - 0.18 10.5 4.6 0.33 9.7 4.6 1.4 1 0 0 1 1 1 0 Ureide permease DUF4228 PF14009.6 EFA80259.1 - 0.19 12.1 4.8 0.067 13.6 2.6 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) TERB2 PF15101.6 EFA80259.1 - 0.28 11.2 14.8 0.48 10.4 14.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF702 PF05142.12 EFA80259.1 - 0.72 10.3 9.0 1.3 9.5 9.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Roughex PF06020.11 EFA80259.1 - 0.79 8.8 10.9 1.4 7.9 10.9 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Kei1 PF08552.11 EFA80259.1 - 1.6 8.6 3.6 2.9 7.7 3.6 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Pex14_N PF04695.13 EFA80259.1 - 2.1 9.0 22.9 0.15 12.7 17.0 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Folliculin PF11704.8 EFA80259.1 - 2.3 8.1 12.7 1.8 8.4 6.1 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2967 PF11179.8 EFA80259.1 - 2.5 6.1 13.5 3.2 5.8 13.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF4175 PF13779.6 EFA80259.1 - 3.6 5.4 26.3 4.8 5.0 26.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Serinc PF03348.15 EFA80259.1 - 7.4 5.4 6.9 11 4.8 6.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Connexin PF00029.19 EFA80259.1 - 8.6 6.0 11.2 0.47 10.2 6.2 1.6 2 0 0 2 2 2 0 Connexin SID-1_RNA_chan PF13965.6 EFA80259.1 - 9.5 4.5 8.5 15 3.8 8.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Iso_dh PF00180.20 EFA80260.1 - 7.5e-78 262.1 0.0 9e-78 261.8 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CBFD_NFYB_HMF PF00808.23 EFA80261.1 - 1.2e-11 44.7 0.1 2.5e-11 43.7 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF913 PF06025.12 EFA80261.1 - 0.013 14.5 4.6 0.014 14.4 4.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 EFA80261.1 - 0.018 13.4 9.7 0.018 13.4 9.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4770 PF15994.5 EFA80261.1 - 0.027 14.7 1.0 0.032 14.5 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RNA_pol_Rpc4 PF05132.14 EFA80261.1 - 0.042 14.3 5.8 0.038 14.4 5.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 EFA80261.1 - 0.053 13.7 4.9 0.053 13.7 4.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sporozoite_P67 PF05642.11 EFA80261.1 - 0.083 11.0 12.8 0.093 10.8 12.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 EFA80261.1 - 0.16 10.5 5.7 0.15 10.6 5.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Histone PF00125.24 EFA80261.1 - 0.19 12.1 0.0 0.19 12.1 0.0 2.2 2 0 0 2 2 1 0 Core histone H2A/H2B/H3/H4 SID-1_RNA_chan PF13965.6 EFA80261.1 - 0.52 8.6 2.1 0.5 8.7 2.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Vfa1 PF08432.10 EFA80261.1 - 0.57 10.5 18.0 0.75 10.1 18.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1840 PF08895.11 EFA80261.1 - 1 9.7 7.5 2.9 8.3 6.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) CobT PF06213.12 EFA80261.1 - 1.2 8.5 14.0 1.5 8.2 14.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT POX PF07526.11 EFA80261.1 - 1.8 9.1 9.1 3 8.4 9.1 1.4 1 0 0 1 1 1 0 Associated with HOX Tim54 PF11711.8 EFA80261.1 - 6.5 5.4 10.7 8.4 5.1 10.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HicA_toxin PF07927.12 EFA80262.1 - 0.0014 18.6 0.2 0.051 13.6 0.1 2.4 2 0 0 2 2 2 1 HicA toxin of bacterial toxin-antitoxin, Mucin PF01456.17 EFA80262.1 - 0.041 13.9 8.8 0.063 13.3 8.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Chorion_3 PF05387.11 EFA80262.1 - 0.26 10.9 4.4 0.31 10.6 4.4 1.2 1 0 0 1 1 1 0 Chorion family 3 Macoilin PF09726.9 EFA80262.1 - 8.4 4.8 14.4 9 4.7 14.4 1.0 1 0 0 1 1 1 0 Macoilin family NAD_kinase PF01513.21 EFA80263.1 - 6.9e-57 192.9 0.0 8.1e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EFA80263.1 - 0.0094 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF4535 PF15054.6 EFA80264.1 - 3.6e-12 45.8 0.3 3.7e-12 45.8 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) AA_permease_2 PF13520.6 EFA80265.1 - 5e-47 160.7 48.0 5e-47 160.7 48.0 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFA80265.1 - 5.4e-42 144.0 45.6 6.7e-42 143.7 44.8 1.5 1 1 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 EFA80265.1 - 8e-18 64.3 2.3 8e-18 64.3 2.3 3.6 3 0 0 3 3 3 1 C-terminus of AA_permease Spore_permease PF03845.13 EFA80265.1 - 0.00017 20.5 19.0 0.00017 20.5 19.0 3.7 2 2 0 3 3 3 1 Spore germination protein MMgT PF10270.9 EFA80265.1 - 0.19 12.1 1.8 2.1 8.7 0.0 2.8 2 1 0 2 2 2 0 Membrane magnesium transporter COX14 PF14880.6 EFA80265.1 - 2.1 8.2 8.4 18 5.2 0.1 3.7 3 0 0 3 3 3 0 Cytochrome oxidase c assembly DnaJ PF00226.31 EFA80266.1 - 1e-17 64.0 0.3 1.7e-17 63.3 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain Orf78 PF06024.12 EFA80266.1 - 0.075 13.3 0.1 0.075 13.3 0.1 4.5 4 2 1 5 5 5 0 Orf78 (ac78) Menin PF05053.13 EFA80266.1 - 0.097 11.0 10.8 0.13 10.6 10.8 1.1 1 0 0 1 1 1 0 Menin DUF4401 PF14351.6 EFA80266.1 - 0.3 10.4 11.2 4 6.6 10.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4401) PEMT PF04191.13 EFA80267.1 - 2.4e-54 182.2 10.4 1.2e-32 112.5 1.6 2.9 2 0 0 2 2 2 2 Phospholipid methyltransferase DUF5521 PF17659.1 EFA80267.1 - 3.9 5.2 8.6 6.2 4.5 8.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5521) PP2C PF00481.21 EFA80268.1 - 2.9e-48 164.8 2.2 2.9e-48 164.8 2.2 2.3 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 EFA80268.1 - 0.0047 16.6 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C Cnd3 PF12719.7 EFA80269.1 - 2.5e-39 135.2 13.3 1.2e-38 133.0 11.5 3.1 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Acyl-CoA_dh_M PF02770.19 EFA80269.1 - 2.3e-17 63.0 0.0 4.9e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain ACOX PF01756.19 EFA80269.1 - 2.1e-08 33.9 0.1 8.8e-08 31.9 0.1 2.0 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 EFA80269.1 - 3.5e-07 30.5 0.0 7.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain zf-C3HC4 PF00097.25 EFA80269.1 - 0.02 14.8 1.5 0.071 13.0 1.5 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Acyl-CoA_ox_N PF14749.6 EFA80269.1 - 0.072 13.7 4.6 5.4 7.6 0.0 3.8 3 0 0 3 3 3 0 Acyl-coenzyme A oxidase N-terminal WD40 PF00400.32 EFA80271.1 - 5.3e-07 30.2 10.1 0.011 16.6 0.0 5.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80271.1 - 0.0034 17.6 0.2 6 7.2 0.0 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain LRR_4 PF12799.7 EFA80272.1 - 6.6e-24 83.6 73.5 0.00016 22.0 1.3 17.6 6 4 11 19 19 19 11 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFA80272.1 - 0.0025 17.7 69.1 5.5 7.3 0.0 19.5 23 0 0 23 23 23 5 Leucine Rich repeat AIM3 PF17096.5 EFA80272.1 - 0.41 11.6 1.7 1.2 10.2 1.7 1.7 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 DUF1699 PF08004.11 EFA80272.1 - 0.41 10.3 11.0 43 3.8 0.0 6.6 5 2 2 7 7 7 0 Protein of unknown function (DUF1699) EIF4E-T PF10477.9 EFA80272.1 - 1.1 8.0 12.9 1.7 7.4 12.9 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E LRR_2 PF07723.13 EFA80272.1 - 1.5 9.6 5.6 52 4.7 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich Repeat SAM_Ste50p PF09235.10 EFA80272.1 - 2.9 8.2 15.7 27 5.1 0.1 6.1 4 2 2 6 6 6 0 Ste50p, sterile alpha motif PH PF00169.29 EFA80273.1 - 2.6e-09 37.5 0.0 9.9e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 PH domain HA2 PF04408.23 EFA80274.1 - 4.9e-23 81.5 3.6 5.8e-23 81.2 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA80274.1 - 4.6e-18 65.4 0.0 1.8e-17 63.5 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFA80274.1 - 3.3e-12 46.7 0.0 1.4e-11 44.7 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain F_actin_bind PF08919.10 EFA80274.1 - 2.5e-09 37.2 1.6 8e-09 35.6 1.6 1.9 1 0 0 1 1 1 1 F-actin binding DEAD PF00270.29 EFA80274.1 - 1.7e-07 31.2 0.2 4.3e-07 29.9 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA80274.1 - 6.5e-05 23.2 0.1 0.00027 21.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA80274.1 - 0.0011 19.3 0.1 0.003 17.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA80274.1 - 0.0048 16.7 0.1 0.011 15.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 EFA80274.1 - 0.0049 16.9 0.0 0.0098 15.9 0.0 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain IstB_IS21 PF01695.17 EFA80274.1 - 0.017 14.9 0.1 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_tran PF00005.27 EFA80274.1 - 0.045 14.3 7.6 0.17 12.4 0.2 3.5 1 1 1 3 3 3 0 ABC transporter ResIII PF04851.15 EFA80274.1 - 0.5 10.4 0.0 0.5 10.4 0.0 3.2 2 1 0 3 3 2 0 Type III restriction enzyme, res subunit PAM2 PF07145.15 EFA80275.1 - 0.0019 17.8 0.6 0.0058 16.2 0.6 1.9 1 0 0 1 1 1 1 Ataxin-2 C-terminal region CaKB PF03185.15 EFA80276.1 - 0.12 12.0 0.2 0.24 11.0 0.2 1.5 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Acyl_transf_1 PF00698.21 EFA80277.1 - 4.7e-39 134.8 0.0 5.7e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain DUF1082 PF06449.11 EFA80277.1 - 0.14 12.0 0.5 27 4.7 0.0 3.3 3 0 0 3 3 3 0 Mitochondrial domain of unknown function (DUF1082) Med15 PF09606.10 EFA80278.1 - 4.5e-05 22.4 0.5 4.5e-05 22.4 0.5 3.3 2 1 1 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal Yae1_N PF09811.9 EFA80279.1 - 1.2e-10 40.9 0.3 1.6e-10 40.5 0.3 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Prefoldin_2 PF01920.20 EFA80280.1 - 1.1e-18 67.1 13.8 1.1e-18 67.1 13.8 2.9 1 1 2 3 3 3 1 Prefoldin subunit Hormone_1 PF00103.20 EFA80280.1 - 0.0038 17.0 3.9 0.0038 17.0 3.9 2.1 2 0 0 2 2 2 1 Somatotropin hormone family OmpH PF03938.14 EFA80280.1 - 0.028 14.8 8.5 0.028 14.8 8.5 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HNHc_6 PF16784.5 EFA80280.1 - 0.056 13.0 3.1 0.085 12.4 3.1 1.3 1 0 0 1 1 1 0 Putative HNHc nuclease DUF501 PF04417.12 EFA80280.1 - 0.29 10.9 10.3 0.51 10.1 2.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF501) Lipocalin_2 PF08212.12 EFA80280.1 - 0.63 10.0 6.6 0.22 11.4 2.1 2.0 2 0 0 2 2 2 0 Lipocalin-like domain FlxA PF14282.6 EFA80280.1 - 1.5 8.9 47.4 0.21 11.6 27.8 2.3 2 0 0 2 2 2 0 FlxA-like protein COG2 PF06148.11 EFA80280.1 - 1.8 8.6 15.9 0.87 9.7 3.1 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CENP-H PF05837.12 EFA80280.1 - 2.4 8.6 21.6 3.2 8.2 11.2 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Tropomyosin_1 PF12718.7 EFA80280.1 - 6.6 6.9 26.7 0.55 10.4 11.9 2.2 2 0 0 2 2 2 0 Tropomyosin like XhlA PF10779.9 EFA80280.1 - 8.8 6.6 12.9 2.3 8.5 3.8 2.3 2 0 0 2 2 2 0 Haemolysin XhlA FMN_red PF03358.15 EFA80281.1 - 1.5e-23 83.2 0.0 2e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFA80281.1 - 0.0017 18.1 0.0 0.0023 17.7 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Peptidase_M18 PF02127.15 EFA80282.1 - 6.4e-144 479.9 0.0 1.2e-143 479.1 0.0 1.3 2 0 0 2 2 2 1 Aminopeptidase I zinc metalloprotease (M18) TIMELESS PF04821.14 EFA80283.1 - 1.2e-44 152.6 6.0 1.2e-44 152.6 6.0 6.8 4 1 1 5 5 5 1 Timeless protein DUF913 PF06025.12 EFA80283.1 - 0.0038 16.2 0.5 0.0038 16.2 0.5 8.1 3 1 2 5 5 5 1 Domain of Unknown Function (DUF913) Aminotran_5 PF00266.19 EFA80284.1 - 1.4e-13 50.5 0.0 1.9e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V SHMT PF00464.19 EFA80284.1 - 0.021 13.4 0.0 0.03 12.9 0.0 1.2 1 0 0 1 1 1 0 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 EFA80284.1 - 0.023 14.0 0.0 0.063 12.6 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1322 PF07032.11 EFA80284.1 - 0.035 14.6 3.0 0.95 10.0 1.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1322) Skp1_POZ PF03931.15 EFA80285.1 - 4.9e-06 26.6 0.0 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 EFA80285.1 - 0.0032 17.7 0.0 0.004 17.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Iso_dh PF00180.20 EFA80286.1 - 1e-42 146.5 0.5 1.1e-42 146.4 0.5 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Acetyltransf_14 PF03421.16 EFA80286.1 - 0.047 13.8 0.1 0.067 13.3 0.1 1.2 1 0 0 1 1 1 0 YopJ Serine/Threonine acetyltransferase Iso_dh PF00180.20 EFA80287.1 - 9.4e-36 123.7 0.0 1.1e-35 123.4 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Mito_carr PF00153.27 EFA80288.1 - 3.4e-52 174.3 1.1 1.8e-22 79.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Coiled PF05710.12 EFA80289.1 - 9.9e-18 64.8 19.4 1.1e-17 64.6 19.4 1.0 1 0 0 1 1 1 1 Coiled coil Acyl_transf_1 PF00698.21 EFA80290.1 - 1.6e-27 96.9 0.0 2e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain Coiled PF05710.12 EFA80290.1 - 1.2e-13 51.7 7.5 1.2e-13 51.7 7.5 2.0 2 0 0 2 2 2 1 Coiled coil E1-E2_ATPase PF00122.20 EFA80291.1 - 3.6e-21 75.5 0.0 8.8e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFA80291.1 - 9.9e-20 71.7 0.0 1.1e-10 42.2 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA80291.1 - 3.9e-05 23.7 0.0 9.8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFA80291.1 - 6e-05 22.9 0.0 0.11 12.2 0.0 2.8 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Kelch_2 PF07646.15 EFA80292.1 - 1.5e-06 27.9 0.3 5e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 EFA80292.1 - 0.0005 20.0 0.9 0.00063 19.7 0.1 1.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA80292.1 - 0.00054 19.5 0.5 0.00073 19.1 0.1 1.5 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EFA80292.1 - 0.0047 16.9 0.0 0.0057 16.6 0.0 1.2 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 EFA80292.1 - 0.03 14.6 0.7 0.043 14.1 0.2 1.7 2 1 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 EFA80293.1 - 2.4e-14 53.1 0.8 1.9e-06 27.7 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA80293.1 - 1.3e-13 50.6 0.2 1.4e-07 31.4 0.0 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFA80293.1 - 1.3e-13 50.9 0.1 3.2e-05 24.1 0.0 2.9 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA80293.1 - 1.2e-09 37.6 0.1 1.9e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 EFA80293.1 - 3.5e-09 36.6 0.8 0.00071 19.8 0.1 2.7 2 1 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EFA80293.1 - 1e-07 31.6 0.2 0.002 18.0 0.0 2.4 2 0 0 2 2 2 2 Kelch motif K-box PF01486.17 EFA80293.1 - 0.0048 17.0 5.2 0.0048 17.0 5.2 2.7 2 1 0 2 2 2 1 K-box region Mac PF12464.8 EFA80295.1 - 2.6e-16 59.6 0.1 4e-16 59.0 0.1 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 EFA80295.1 - 1.9e-13 49.6 14.0 5e-11 41.9 6.8 2.7 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFA80295.1 - 8.5e-13 47.8 15.0 6.2e-09 35.5 5.8 2.9 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase RasGEF PF00617.19 EFA80296.1 - 3.3e-34 118.6 0.5 3.3e-34 118.6 0.5 2.4 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFA80296.1 - 1.3e-13 51.1 0.3 1.3e-13 51.1 0.3 3.7 3 1 0 3 3 3 1 RasGEF N-terminal motif Phage_holin_2_4 PF16082.5 EFA80296.1 - 0.042 13.6 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Adeno_E3_CR2 PF02439.15 EFA80296.1 - 0.11 12.3 0.6 0.4 10.5 0.0 2.1 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 AbrB PF05145.12 EFA80296.1 - 0.22 10.4 0.0 0.35 9.8 0.0 1.2 1 0 0 1 1 1 0 Transition state regulatory protein AbrB RVT_1 PF00078.27 EFA80297.1 - 1.1e-31 110.1 0.4 3.1e-31 108.6 0.4 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SWI-SNF_Ssr4 PF08549.10 EFA80297.1 - 6.1 5.3 9.2 10 4.6 9.2 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) tRNA-synt_2 PF00152.20 EFA80298.1 - 3.9e-44 151.0 0.3 9.2e-44 149.8 0.3 1.5 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) SapB_2 PF03489.17 EFA80299.1 - 2.4e-22 78.7 27.8 1.5e-11 44.2 2.0 4.4 5 0 0 5 5 5 3 Saposin-like type B, region 2 SapB_1 PF05184.15 EFA80299.1 - 4e-22 77.9 10.6 3.8e-12 46.0 3.8 3.6 3 0 0 3 3 3 2 Saposin-like type B, region 1 DUF749 PF05370.11 EFA80299.1 - 0.014 15.5 0.1 0.29 11.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF749) Lung_7-TM_R PF06814.13 EFA80300.1 - 1.3e-12 47.6 14.5 1.3e-12 47.6 14.5 2.4 2 0 0 2 2 2 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 EFA80300.1 - 3e-07 30.1 13.5 3e-07 30.1 13.5 3.0 3 1 0 3 3 3 1 Rhodopsin-like GPCR transmembrane domain DUF1180 PF06679.12 EFA80300.1 - 0.062 13.7 1.0 0.16 12.4 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Man-6-P_recep PF02157.15 EFA80300.1 - 0.13 11.3 3.9 0.95 8.5 0.3 2.4 2 0 0 2 2 2 0 Mannose-6-phosphate receptor Pkinase PF00069.25 EFA80301.1 - 2.6e-64 217.1 0.0 3.9e-64 216.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80301.1 - 2.4e-45 154.8 0.0 4e-45 154.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA80301.1 - 4.1e-06 25.8 0.1 1.2e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFA80301.1 - 7.5e-05 22.8 0.0 0.0022 17.9 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFA80301.1 - 0.00019 21.1 0.1 0.00036 20.2 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFA80301.1 - 0.0016 17.9 0.0 0.0038 16.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like BRX_assoc PF16627.5 EFA80301.1 - 0.011 15.9 1.9 0.024 14.7 1.9 1.5 1 0 0 1 1 1 0 Unstructured region between BRX_N and BRX domain Haspin_kinase PF12330.8 EFA80301.1 - 0.013 14.4 0.2 0.031 13.2 0.2 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFA80301.1 - 0.021 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFA80301.1 - 0.037 13.6 0.4 0.12 11.9 0.0 1.8 1 1 1 2 2 2 0 Choline/ethanolamine kinase PBD PF00786.28 EFA80301.1 - 0.11 12.8 0.0 0.55 10.6 0.0 2.2 1 0 0 1 1 1 0 P21-Rho-binding domain Complex1_LYR PF05347.15 EFA80302.1 - 6e-14 51.8 0.7 7.9e-14 51.5 0.7 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFA80302.1 - 0.0014 19.4 2.1 0.0016 19.2 2.1 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EFA80302.1 - 0.035 14.7 0.2 0.042 14.4 0.2 1.2 1 0 0 1 1 1 0 Complex1_LYR-like Sgf11 PF08209.11 EFA80303.1 - 7.7e-11 41.4 0.1 1.2e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) tRNA-synt_2 PF00152.20 EFA80304.1 - 3.8e-78 262.7 0.2 7.4e-78 261.8 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFA80304.1 - 2.8e-06 27.2 0.0 5.1e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFA80304.1 - 0.024 14.1 2.9 0.54 9.7 0.1 2.6 1 1 1 2 2 2 0 tRNA synthetases class II core domain (F) Roughex PF06020.11 EFA80304.1 - 1.7 7.6 4.5 2.9 6.9 4.5 1.3 1 0 0 1 1 1 0 Drosophila roughex protein CCDC-167 PF15188.6 EFA80304.1 - 3.8 7.9 10.9 0.71 10.3 3.2 2.7 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 Maf1 PF09174.10 EFA80304.1 - 4.5 7.4 6.3 1.3 9.2 2.8 1.8 2 0 0 2 2 2 0 Maf1 regulator DEAD PF00270.29 EFA80305.1 - 8.4e-49 165.7 0.0 1.6e-48 164.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA80305.1 - 1.3e-30 106.0 0.0 6.1e-29 100.6 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA80305.1 - 0.0066 16.5 0.0 0.0066 16.5 0.0 3.5 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Ank_4 PF13637.6 EFA80306.1 - 2.5e-23 82.1 8.7 7.3e-09 36.0 0.1 3.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80306.1 - 6.7e-21 74.7 0.9 5.2e-10 39.8 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFA80306.1 - 9.4e-19 67.0 2.0 0.00035 20.9 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFA80306.1 - 3.7e-16 59.0 7.8 9.4e-06 25.8 0.1 3.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80306.1 - 1.6e-13 49.5 1.3 0.013 16.0 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ribosomal_S3Ae PF01015.18 EFA80307.1 - 1.8e-83 279.1 7.5 2.2e-83 278.8 7.5 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DUF3130 PF11328.8 EFA80307.1 - 0.013 15.8 0.3 1.5 9.1 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3130 Abhydro_lipase PF04083.16 EFA80307.1 - 0.04 13.5 0.0 0.081 12.5 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Lipin_mid PF16876.5 EFA80308.1 - 0.065 13.4 0.4 0.54 10.4 0.0 2.6 2 0 0 2 2 2 0 Lipin/Ned1/Smp2 multi-domain protein middle domain QWRF PF04484.12 EFA80308.1 - 0.78 9.4 10.8 2 8.1 10.8 1.6 1 0 0 1 1 1 0 QWRF family FAM176 PF14851.6 EFA80308.1 - 0.96 9.1 11.5 0.21 11.3 1.1 3.0 3 0 0 3 3 3 0 FAM176 family Pex14_N PF04695.13 EFA80308.1 - 1.4 9.5 7.2 1.6 9.3 2.4 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1840 PF08895.11 EFA80308.1 - 2.4 8.5 4.6 2.3 8.6 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) Blt1 PF12754.7 EFA80308.1 - 7.4 6.9 7.3 2.9 8.2 3.2 2.4 3 0 0 3 3 3 0 Blt1 N-terminal domain Adap_comp_sub PF00928.21 EFA80309.1 - 5.2e-90 301.4 0.3 6.6e-90 301.1 0.3 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFA80309.1 - 5e-09 36.2 0.8 8.9e-09 35.4 0.8 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SIR2 PF02146.17 EFA80312.1 - 5.8e-58 195.7 0.0 1e-57 194.9 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EFA80312.1 - 0.0059 16.4 0.0 4 7.2 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain WD40 PF00400.32 EFA80313.1 - 7.2e-16 58.3 11.4 2e-05 25.3 0.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat SUIM_assoc PF16619.5 EFA80313.1 - 0.0015 18.5 3.2 0.0031 17.5 3.2 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Peptidase_S9 PF00326.21 EFA80313.1 - 0.022 14.2 1.5 0.056 12.9 0.4 2.1 1 1 1 2 2 2 0 Prolyl oligopeptidase family RLL PF10036.9 EFA80313.1 - 0.045 13.6 3.8 0.4 10.5 4.8 1.9 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein Presenilin PF01080.17 EFA80313.1 - 0.095 11.5 3.9 0.16 10.7 3.9 1.2 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 EFA80313.1 - 0.22 10.6 3.1 0.36 9.9 3.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein FNIP PF05725.12 EFA80314.1 - 2.5e-32 110.8 20.6 3.8e-11 43.0 0.2 5.4 5 1 3 8 8 8 6 FNIP Repeat F-box_5 PF18511.1 EFA80314.1 - 0.0009 18.8 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 F-box L51_S25_CI-B8 PF05047.16 EFA80315.1 - 1.5e-07 31.2 0.0 3e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Ribosomal_L4 PF00573.22 EFA80316.1 - 4e-52 176.7 0.2 4e-52 176.7 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Cyt-b5 PF00173.28 EFA80317.1 - 2.6e-21 75.5 0.0 4.1e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-MIZ PF02891.20 EFA80318.1 - 0.021 14.6 0.4 0.062 13.1 0.4 1.8 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger BTB PF00651.31 EFA80319.1 - 1.3e-24 86.6 1.7 8.3e-24 84.0 0.2 2.9 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EFA80319.1 - 5.5e-05 23.2 0.1 0.21 11.7 0.0 4.4 5 0 0 5 5 5 1 BTB And C-terminal Kelch DUF3342 PF11822.8 EFA80319.1 - 0.0004 20.5 0.1 0.14 12.4 0.0 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF3342) PIG-H PF10181.9 EFA80321.1 - 4.3e-19 68.1 0.4 4.3e-19 68.1 0.4 1.9 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component Pex24p PF06398.11 EFA80321.1 - 0.034 13.1 0.1 0.059 12.3 0.0 1.3 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin LRR_6 PF13516.6 EFA80322.1 - 2.4e-09 36.5 8.8 0.14 12.2 0.0 6.9 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 EFA80322.1 - 0.0048 17.3 15.5 0.1 13.1 0.1 6.3 6 1 1 7 7 7 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA80322.1 - 0.009 15.8 11.6 1.3 8.8 0.1 5.9 6 1 0 6 6 6 2 Leucine rich repeat LRR_1 PF00560.33 EFA80322.1 - 0.37 11.5 13.9 33 5.6 0.1 7.4 10 0 0 10 10 10 0 Leucine Rich Repeat Peptidase_S28 PF05577.12 EFA80323.1 - 6.7e-127 423.9 0.5 7.7e-127 423.7 0.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EFA80323.1 - 7.5e-06 25.8 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA80323.1 - 0.00077 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S37 PF05576.11 EFA80323.1 - 0.0052 15.5 0.1 0.0072 15.1 0.1 1.2 1 0 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.21 EFA80323.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF2920 PF11144.8 EFA80323.1 - 0.043 13.0 0.3 0.81 8.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2920) DUF3586 PF12131.8 EFA80324.1 - 1.1 9.6 19.3 0.36 11.1 2.4 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF3586) RVT_1 PF00078.27 EFA80327.1 - 0.0015 18.1 0.1 0.0026 17.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SatD PF16264.5 EFA80327.1 - 0.019 14.6 0.0 0.031 13.9 0.0 1.5 1 1 0 1 1 1 0 SatD family (SatD) Pkinase PF00069.25 EFA80330.1 - 1.7e-43 148.9 0.0 2.8e-43 148.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80330.1 - 4.6e-26 91.7 0.0 6.7e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA80330.1 - 6.9e-11 42.0 0.0 9.8e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFA80330.1 - 0.014 15.3 0.0 0.3 11.0 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA80330.1 - 0.032 13.0 0.1 0.032 13.0 0.1 1.7 2 0 0 2 2 2 0 Fungal protein kinase Macoilin PF09726.9 EFA80330.1 - 2.4 6.6 9.6 3.1 6.3 9.6 1.1 1 0 0 1 1 1 0 Macoilin family Pribosyltran PF00156.27 EFA80331.1 - 7.5e-26 90.6 0.0 9.3e-26 90.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFA80331.1 - 3.3e-06 26.7 0.0 5.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EFA80331.1 - 0.00011 21.8 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase EGF_2 PF07974.13 EFA80332.1 - 1.3 9.4 14.1 2.6 8.5 14.1 1.5 1 0 0 1 1 1 0 EGF-like domain LIN52 PF10044.9 EFA80333.1 - 0.059 14.1 1.3 0.059 14.1 1.3 2.7 2 1 1 3 3 3 0 Retinal tissue protein Lipase_3 PF01764.25 EFA80335.1 - 6.3e-24 84.5 0.0 1.4e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 EFA80335.1 - 3.2e-05 23.5 0.0 6.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF2974 PF11187.8 EFA80335.1 - 0.0025 17.4 0.0 0.029 13.9 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) GP11 PF08677.10 EFA80335.1 - 0.045 13.2 0.0 0.083 12.3 0.0 1.4 1 0 0 1 1 1 0 GP11 baseplate wedge protein PGAP1 PF07819.13 EFA80335.1 - 0.075 12.7 0.3 0.59 9.8 0.1 2.1 1 1 1 2 2 2 0 PGAP1-like protein YpM PF09144.10 EFA80335.1 - 0.076 13.2 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Yersinia pseudo-tuberculosis mitogen Esterase PF00756.20 EFA80335.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.4 1 1 0 1 1 1 0 Putative esterase DUF1345 PF07077.11 EFA80336.1 - 0.27 10.9 4.0 0.36 10.5 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) DUF1425 PF07233.12 EFA80336.1 - 0.47 10.4 0.2 0.47 10.4 0.2 1.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1425) G-gamma PF00631.22 EFA80337.1 - 9.1e-15 54.4 0.1 9.8e-15 54.3 0.1 1.0 1 0 0 1 1 1 1 GGL domain NEMO PF11577.8 EFA80337.1 - 0.054 13.5 0.3 0.068 13.2 0.3 1.3 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO F_actin_bind PF08919.10 EFA80337.1 - 0.085 13.0 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 F-actin binding THOC7 PF05615.13 EFA80337.1 - 0.11 12.8 0.1 0.12 12.6 0.1 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 RNA_pol_Rpb1_1 PF04997.12 EFA80337.1 - 0.12 11.7 0.0 0.14 11.5 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 G_path_suppress PF15991.5 EFA80337.1 - 0.13 12.4 0.0 0.13 12.4 0.0 1.0 1 0 0 1 1 1 0 G-protein pathway suppressor RRM_1 PF00076.22 EFA80338.1 - 1.2e-60 201.2 0.9 6.3e-19 67.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFA80338.1 - 1.4e-05 25.0 0.0 0.27 11.3 0.0 3.5 3 0 0 3 3 3 2 RNA binding motif RRM_occluded PF16842.5 EFA80338.1 - 0.0013 18.6 0.0 0.0042 16.9 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EFA80338.1 - 0.0029 17.7 0.2 4.4 7.5 0.0 3.9 3 0 0 3 3 3 1 RNA recognition motif SET_assoc PF11767.8 EFA80338.1 - 0.042 13.5 0.0 5.5 6.7 0.0 3.2 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated RNA_bind PF08675.11 EFA80338.1 - 0.052 13.6 0.0 5.9 7.0 0.0 3.3 3 0 0 3 3 3 0 RNA binding domain Nrap_D6 PF17407.2 EFA80338.1 - 0.3 11.3 4.8 2.3 8.4 0.2 2.9 2 0 0 2 2 2 0 Nrap protein domain 6 RRS1 PF04939.12 EFA80339.1 - 1.1e-47 161.9 8.2 1.1e-47 161.9 8.2 1.7 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) PPARgamma_N PF12577.8 EFA80339.1 - 0.0016 19.1 0.1 0.0052 17.4 0.1 1.9 1 0 0 1 1 1 1 PPAR gamma N-terminal region Nckap1 PF09735.9 EFA80340.1 - 0 1309.9 7.9 0 1309.7 7.9 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein DUF3429 PF11911.8 EFA80341.1 - 0.0072 16.6 2.4 0.01 16.1 2.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Erf4 PF10256.9 EFA80342.1 - 1.9e-06 28.0 0.1 6.6e-06 26.2 0.1 1.8 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Ribosomal_L28e PF01778.17 EFA80343.1 - 0.0037 18.0 0.0 0.005 17.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L28e protein family NDT80_PhoG PF05224.12 EFA80344.1 - 4.3e-16 59.7 0.0 4.3e-16 59.7 0.0 5.1 4 2 0 4 4 4 1 NDT80 / PhoG like DNA-binding family Peptidase_S74 PF13884.6 EFA80344.1 - 2.3e-15 56.6 0.1 5.3e-15 55.5 0.1 1.7 1 0 0 1 1 1 1 Chaperone of endosialidase DUF3430 PF11912.8 EFA80345.1 - 0.00015 21.9 39.3 0.00038 20.6 39.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3430) Voltage_CLC PF00654.20 EFA80346.1 - 1.8e-66 224.8 30.0 3.4e-66 223.9 29.0 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EFA80346.1 - 1.3e-07 31.9 0.1 0.0015 18.9 0.0 2.5 2 0 0 2 2 2 2 CBS domain DUF3523 PF12037.8 EFA80346.1 - 0.032 13.6 1.8 0.06 12.7 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) F5_F8_type_C PF00754.25 EFA80347.1 - 5.5e-23 81.5 3.4 9.8e-23 80.7 3.4 1.3 1 0 0 1 1 1 1 F5/8 type C domain H_lectin PF09458.10 EFA80347.1 - 1.7e-11 44.2 3.0 1.7e-11 44.2 3.0 2.1 2 0 0 2 2 2 1 H-type lectin domain NapB PF03892.14 EFA80347.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) TRAPPC9-Trs120 PF08626.11 EFA80348.1 - 1e-81 274.9 16.7 3.2e-53 180.5 11.7 3.1 1 1 2 3 3 3 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF5100 PF17029.5 EFA80348.1 - 0.015 15.2 6.8 0.064 13.1 6.8 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5100) Foie-gras_1 PF11817.8 EFA80348.1 - 0.029 14.0 0.1 4.3 6.8 0.3 2.4 2 0 0 2 2 2 0 Foie gras liver health family 1 Cyclin PF08613.11 EFA80349.1 - 1e-21 78.0 0.2 1e-21 78.0 0.2 3.0 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFA80349.1 - 2e-06 27.6 0.0 4.6e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Menin PF05053.13 EFA80349.1 - 8.9 4.5 11.6 12 4.1 11.6 1.2 1 0 0 1 1 1 0 Menin Methyltrn_RNA_3 PF02598.17 EFA80351.1 - 1.1e-55 189.2 0.1 4.4e-55 187.2 0.1 2.0 1 1 0 1 1 1 1 Putative RNA methyltransferase HAUS5 PF14817.6 EFA80351.1 - 0.00084 18.2 2.9 0.0014 17.5 2.9 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 OmpH PF03938.14 EFA80351.1 - 0.0037 17.6 4.8 0.0037 17.6 4.8 2.5 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) KCNQ2_u3 PF16642.5 EFA80351.1 - 0.046 14.7 2.0 0.18 12.8 2.0 2.0 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 UPF0564 PF10595.9 EFA80351.1 - 0.26 10.3 27.7 0.016 14.3 22.6 1.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 DUF4407 PF14362.6 EFA80351.1 - 0.81 9.0 7.8 1.6 8.0 7.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 EFA80351.1 - 1.3 9.0 20.6 2.8 8.0 19.8 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Reticulon PF02453.17 EFA80352.1 - 1.1e-07 32.0 5.1 1.8e-07 31.2 5.1 1.3 1 0 0 1 1 1 1 Reticulon Promethin PF16015.5 EFA80352.1 - 2.9 7.9 8.5 7.1 6.6 0.5 2.3 2 0 0 2 2 2 0 Promethin Ank_2 PF12796.7 EFA80353.1 - 3.2e-22 78.9 16.1 2.5e-08 34.4 0.1 5.8 3 1 4 7 7 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80353.1 - 2.7e-21 75.7 10.1 5.2e-06 26.9 0.2 7.0 6 0 0 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA80353.1 - 4.1e-15 55.6 13.2 0.033 14.5 0.2 10.1 2 1 8 10 10 10 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80353.1 - 1e-13 50.1 7.6 1.2 9.9 0.0 10.0 8 2 2 10 10 9 2 Ankyrin repeat RWD PF05773.22 EFA80353.1 - 2.8e-09 37.3 1.4 3.1e-08 33.9 0.6 3.0 2 1 0 2 2 2 1 RWD domain IBR PF01485.21 EFA80353.1 - 6.3e-07 29.5 11.0 6.3e-07 29.5 11.0 3.3 1 1 2 3 3 3 1 IBR domain, a half RING-finger domain Ank PF00023.30 EFA80353.1 - 1.4e-05 25.3 1.2 8 7.1 0.0 7.4 3 2 1 4 4 4 1 Ankyrin repeat DUF5049 PF16468.5 EFA80353.1 - 0.023 14.6 0.9 74 3.4 0.0 4.5 3 1 1 4 4 4 0 Domain of unknown function (DUF5049) AhpC-TSA PF00578.21 EFA80353.1 - 0.058 13.3 0.8 2 8.4 0.0 3.0 3 0 0 3 3 3 0 AhpC/TSA family Pex14_N PF04695.13 EFA80353.1 - 0.12 13.1 1.9 2.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAP_RNA-bind PF04926.15 EFA80353.1 - 0.21 11.2 8.8 0.17 11.5 5.2 2.4 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Orf78 PF06024.12 EFA80353.1 - 0.65 10.3 6.7 8.1 6.8 2.2 2.7 2 0 0 2 2 2 0 Orf78 (ac78) Secretin_N_2 PF07655.13 EFA80353.1 - 4.9 7.8 24.6 0.39 11.3 7.7 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Asparaginase_2 PF01112.18 EFA80354.1 - 3.9e-44 150.9 1.1 3.1e-27 95.4 0.1 2.8 3 1 0 3 3 3 2 Asparaginase G_glu_transpept PF01019.21 EFA80354.1 - 0.065 12.0 0.2 0.093 11.5 0.2 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Pkinase_Tyr PF07714.17 EFA80356.1 - 2.5e-61 207.2 0.0 3.5e-61 206.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA80356.1 - 4.1e-49 167.3 0.0 6e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EFA80356.1 - 3.3e-16 59.1 0.0 7.4e-16 58.0 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Haspin_kinase PF12330.8 EFA80356.1 - 9.9e-05 21.4 0.4 0.0045 16.0 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 EFA80356.1 - 0.00079 19.4 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family ABC1 PF03109.16 EFA80356.1 - 0.014 15.5 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Glyco_hydro_38N PF01074.22 EFA80357.1 - 3.1e-62 210.6 0.4 5.3e-62 209.8 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFA80357.1 - 1.9e-16 60.8 1.4 4.3e-16 59.6 1.4 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFA80357.1 - 5.8e-12 45.6 0.0 1.5e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Lung_7-TM_R PF06814.13 EFA80358.1 - 3.6e-51 174.2 11.6 5e-51 173.7 11.6 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 EFA80358.1 - 0.0012 18.4 16.3 0.0024 17.3 16.3 1.5 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain DUF3671 PF12420.8 EFA80358.1 - 1.5 9.0 14.4 3.7 7.7 1.9 3.5 3 0 0 3 3 3 0 Protein of unknown function DUF3810 PF12725.7 EFA80358.1 - 8.1 5.7 11.5 3.8 6.8 1.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) TMEM208_SND2 PF05620.11 EFA80358.1 - 8.9 6.1 8.0 15 5.4 0.2 2.6 2 1 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Ham1p_like PF01725.16 EFA80359.1 - 2.8e-51 174.1 0.0 3.1e-51 174.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Diphthami_syn_2 PF01902.17 EFA80360.1 - 3.7e-40 137.8 0.0 4.9e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Diphthamide synthase DUF3439 PF11921.8 EFA80360.1 - 0.18 11.8 8.3 0.31 11.0 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EFA80360.1 - 8.1 6.4 24.7 12 5.9 24.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF1191 PF06697.12 EFA80362.1 - 0.062 13.1 0.1 0.17 11.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Zip PF02535.22 EFA80362.1 - 0.36 10.0 7.2 0.8 8.9 7.2 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 EFA80362.1 - 0.4 8.9 23.7 0.58 8.4 23.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 EFA80362.1 - 0.44 9.1 22.2 0.67 8.5 22.2 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator RR_TM4-6 PF06459.12 EFA80362.1 - 1.1 9.0 23.1 1.9 8.2 23.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 EFA80362.1 - 4.1 5.8 32.8 8 4.8 32.8 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein GPI2 PF06432.11 EFA80363.1 - 4.7e-88 295.3 21.7 4.7e-88 295.3 21.7 1.6 2 0 0 2 2 2 1 Phosphatidylinositol N-acetylglucosaminyltransferase Pex14_N PF04695.13 EFA80363.1 - 4.1e-05 24.3 0.2 7.5e-05 23.4 0.2 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 EFA80363.1 - 0.0002 20.4 0.3 0.00024 20.2 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Maf1 PF09174.10 EFA80363.1 - 0.00086 19.5 3.9 0.026 14.7 0.7 2.3 2 0 0 2 2 2 2 Maf1 regulator Spt20 PF12090.8 EFA80363.1 - 0.69 9.5 17.4 1.1 8.8 17.4 1.2 1 0 0 1 1 1 0 Spt20 family TMEM173 PF15009.6 EFA80363.1 - 1 8.5 6.8 0.35 10.0 2.4 2.4 1 1 1 2 2 2 0 Transmembrane protein 173 DUF1616 PF07760.11 EFA80363.1 - 2.5 7.4 7.7 4.4 6.6 7.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1616) Androgen_recep PF02166.16 EFA80363.1 - 7.7 5.2 17.2 11 4.7 17.2 1.1 1 0 0 1 1 1 0 Androgen receptor AAT PF03417.16 EFA80364.1 - 2.9e-10 40.2 0.0 8.4e-10 38.7 0.0 1.8 1 1 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase UPF0515 PF15135.6 EFA80365.1 - 1.2e-05 24.8 3.6 1.2e-05 24.8 3.6 1.9 1 1 1 2 2 2 1 Uncharacterised protein UPF0515 zf-3CxxC_2 PF17180.4 EFA80365.1 - 0.23 12.2 4.1 1 10.2 4.1 2.1 1 1 0 1 1 1 0 Zinc-binding domain DUF1906 PF08924.11 EFA80366.1 - 0.092 12.9 1.1 0.13 12.4 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) DUF1610 PF07754.11 EFA80366.1 - 1.1 9.3 11.2 0.82 9.7 3.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) UCH PF00443.29 EFA80367.1 - 3.5e-43 148.0 0.0 6.2e-43 147.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Profilin PF00235.19 EFA80367.1 - 1.7e-11 44.5 0.7 3.7e-11 43.4 0.7 1.5 1 0 0 1 1 1 1 Profilin UCH_1 PF13423.6 EFA80367.1 - 2.7e-05 23.9 0.2 0.011 15.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Glyco_hydro_38N PF01074.22 EFA80368.1 - 2e-83 280.1 0.5 3.1e-83 279.5 0.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFA80368.1 - 3.8e-60 203.6 0.0 1.3e-59 201.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFA80368.1 - 1.2e-22 79.8 0.0 3.1e-22 78.5 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EFA80368.1 - 1e-08 35.2 0.0 2.3e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 EFA80368.1 - 0.02 14.1 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 UPF0552 PF10574.9 EFA80370.1 - 7.1e-23 81.1 0.7 1.5e-22 80.0 0.7 1.5 1 1 0 1 1 1 1 Arp2/3-interacting proteins Arpin DUF4470 PF14737.6 EFA80371.1 - 1.9e-10 40.8 0.0 1.2e-09 38.2 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4470) TPR_1 PF00515.28 EFA80371.1 - 0.0001 22.0 2.0 0.15 11.9 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA80371.1 - 0.00052 19.9 1.3 1.5 9.1 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat SCRG1 PF15224.6 EFA80371.1 - 0.0041 17.2 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Scrapie-responsive protein 1 TPR_12 PF13424.6 EFA80371.1 - 0.01 16.1 0.0 0.11 12.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA80371.1 - 0.014 15.9 0.1 0.071 13.6 0.1 2.3 1 1 0 1 1 1 0 Tetratricopeptide repeat DUF2527 PF10736.9 EFA80371.1 - 0.014 15.2 0.0 0.06 13.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) ANAPC3 PF12895.7 EFA80371.1 - 0.063 13.5 1.6 0.14 12.4 0.4 2.2 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFA80371.1 - 0.082 12.6 1.0 3.7 7.3 0.1 2.5 2 0 0 2 2 2 0 TPR repeat YfhO PF09586.10 EFA80372.1 - 1 7.5 6.0 1.3 7.2 6.0 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Dicty_CTDC PF00526.18 EFA80374.1 - 0 1203.5 1071.8 8.5e-10 38.4 10.8 59.4 59 1 0 59 59 59 58 Dictyostelium (slime mold) repeat AhpC-TSA PF00578.21 EFA80375.1 - 5.4e-38 129.7 0.0 6.9e-38 129.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFA80375.1 - 1e-17 64.2 0.0 1.5e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFA80375.1 - 7.8e-09 35.2 0.0 1.4e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin MBOAT PF03062.19 EFA80377.1 - 5.1e-31 108.3 27.1 5.1e-31 108.3 27.1 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family GET2 PF08690.10 EFA80377.1 - 0.78 9.4 6.4 1.3 8.6 6.4 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 UPF0183 PF03676.14 EFA80378.1 - 2.2e-105 353.2 8.5 4.3e-86 289.7 6.5 2.9 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) DUF5423 PF17461.2 EFA80378.1 - 0.069 12.0 4.2 0.11 11.3 4.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Menin PF05053.13 EFA80378.1 - 5.5 5.2 7.0 7.4 4.8 7.0 1.1 1 0 0 1 1 1 0 Menin NST1 PF13945.6 EFA80378.1 - 6.1 6.9 9.2 11 6.1 9.2 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF1990 PF09348.10 EFA80379.1 - 9.2e-45 152.4 0.0 1.2e-44 152.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1990) zf-HC5HC2H_2 PF13832.6 EFA80381.1 - 1.4e-23 83.2 7.6 1.4e-23 83.2 7.6 2.8 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 EFA80381.1 - 1.4e-19 71.0 19.9 1.4e-19 71.0 19.9 6.3 4 3 1 5 5 2 1 Enhancer of polycomb-like Bromodomain PF00439.25 EFA80381.1 - 8e-19 67.5 2.8 1.7e-18 66.4 1.2 2.5 2 0 0 2 2 2 1 Bromodomain zf-HC5HC2H PF13771.6 EFA80381.1 - 1.6e-18 66.7 5.0 1.6e-18 66.7 5.0 3.8 2 1 0 2 2 1 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EFA80381.1 - 3.6e-13 48.8 4.5 3.6e-13 48.8 4.5 3.2 3 0 0 3 3 3 1 PHD-finger PHD PF00628.29 EFA80381.1 - 6.4e-10 38.8 7.2 6.4e-10 38.8 7.2 4.1 4 1 0 4 4 4 2 PHD-finger zf-PHD-like PF15446.6 EFA80381.1 - 0.0032 17.1 6.1 0.0032 17.1 6.1 4.5 5 0 0 5 5 5 1 PHD/FYVE-zinc-finger like domain DUF3439 PF11921.8 EFA80381.1 - 0.26 11.2 26.8 2.4 8.1 7.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) AT_hook PF02178.19 EFA80381.1 - 1.4 9.1 9.0 4.2 7.6 0.7 2.9 2 0 0 2 2 2 0 AT hook motif Prok-RING_1 PF14446.6 EFA80381.1 - 6 6.9 16.7 0.16 11.9 4.3 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 EFA80381.1 - 7.5 7.0 25.0 0.025 14.9 7.5 3.4 2 1 1 3 3 3 0 RING-like domain VASt PF16016.5 EFA80382.1 - 2.2e-33 115.8 3.0 2.5e-33 115.6 0.9 2.2 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EFA80382.1 - 3.5e-10 39.8 0.4 3.5e-10 39.8 0.4 2.9 3 0 0 3 3 3 1 GRAM domain SH3BGR PF04908.15 EFA80382.1 - 2.7 8.2 6.1 11 6.2 4.0 2.9 2 1 0 2 2 2 0 SH3-binding, glutamic acid-rich protein HEM4 PF02602.15 EFA80383.1 - 6.1e-18 65.0 0.1 2.5e-06 27.0 0.0 3.3 2 2 1 3 3 3 3 Uroporphyrinogen-III synthase HemD HSP90 PF00183.18 EFA80384.1 - 1.5e-227 756.6 39.8 1.9e-227 756.3 39.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFA80384.1 - 4e-14 53.1 0.1 8.3e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFA80384.1 - 1.3e-08 34.8 0.2 1.3e-08 34.8 0.2 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 EFA80384.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN STAT_bind PF02864.15 EFA80384.1 - 5.9 7.5 8.8 45 4.6 3.3 3.5 4 0 0 4 4 4 0 STAT protein, DNA binding domain Ank_2 PF12796.7 EFA80385.1 - 4.7e-37 126.4 1.0 7.4e-06 26.5 0.1 8.3 5 2 2 8 8 8 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80385.1 - 9.1e-30 102.7 7.6 8.7e-06 26.2 0.0 11.7 11 3 3 14 14 14 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80385.1 - 2.5e-26 88.8 6.2 0.17 12.6 0.0 13.6 15 0 0 15 15 15 7 Ankyrin repeat Ank_5 PF13857.6 EFA80385.1 - 1.1e-20 73.4 10.1 0.58 10.5 0.1 13.4 7 4 7 14 14 14 5 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA80385.1 - 1.2e-06 28.3 23.2 0.033 13.9 0.6 6.6 4 2 4 8 8 8 4 Multigene family 530 protein Ank PF00023.30 EFA80385.1 - 0.0021 18.4 0.4 22 5.7 0.0 5.8 7 0 0 7 7 7 1 Ankyrin repeat DrsE PF02635.15 EFA80385.1 - 0.0035 17.7 0.0 0.73 10.2 0.0 2.6 2 0 0 2 2 2 1 DsrE/DsrF-like family DUF3447 PF11929.8 EFA80385.1 - 1.9 8.5 51.2 0.058 13.4 3.8 8.9 7 3 3 10 10 10 0 Domain of unknown function (DUF3447) Kelch_6 PF13964.6 EFA80386.1 - 2.7e-10 40.1 5.7 5.9e-06 26.4 0.2 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA80386.1 - 0.00013 21.5 6.3 0.012 15.2 0.2 3.8 3 0 0 3 3 3 1 Kelch motif zf-B_box PF00643.24 EFA80386.1 - 0.021 14.9 12.4 0.048 13.8 12.4 1.6 1 0 0 1 1 1 0 B-box zinc finger Kelch_5 PF13854.6 EFA80386.1 - 0.11 12.5 12.1 1.4 9.0 0.7 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 EFA80386.1 - 0.18 11.9 4.9 11 6.2 0.2 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 EFA80386.1 - 2.1 8.4 8.1 24 5.0 0.1 4.5 5 2 0 5 5 5 0 Galactose oxidase, central domain Zn_Tnp_IS91 PF14319.6 EFA80386.1 - 4.2 7.5 12.3 15 5.7 1.0 2.7 1 1 1 2 2 2 0 Transposase zinc-binding domain ANAPC4_WD40 PF12894.7 EFA80387.1 - 2.9e-08 33.9 1.2 4e-05 23.8 0.2 3.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA80387.1 - 9.8e-08 32.6 0.8 0.00019 22.1 0.3 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat eIF2A PF08662.11 EFA80387.1 - 0.00025 21.0 0.1 0.0081 16.1 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A CSRNP_N PF16019.5 EFA80387.1 - 9.4 6.1 7.9 15 5.4 7.9 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Ceramidase PF05875.12 EFA80388.1 - 4e-63 213.3 12.9 5.1e-63 213.0 12.9 1.1 1 0 0 1 1 1 1 Ceramidase Glycos_transf_2 PF00535.26 EFA80389.1 - 4.7e-27 94.9 0.0 6e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EFA80389.1 - 2.3e-08 33.9 0.1 3.1e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 EFA80389.1 - 1.1e-07 32.0 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EFA80389.1 - 0.001 19.5 0.0 0.0023 18.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Helicase_C PF00271.31 EFA80390.1 - 3.1e-21 75.8 1.2 8e-18 64.8 0.0 3.3 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EFA80390.1 - 1e-15 58.2 0.2 3.8e-14 53.1 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA80390.1 - 4.8e-15 55.8 0.3 6.1e-13 48.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase dsrm PF00035.26 EFA80390.1 - 9.3e-14 51.9 0.1 5.9e-06 26.9 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif ERCC3_RAD25_C PF16203.5 EFA80390.1 - 0.001 18.4 0.0 0.0025 17.1 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Ribonuc_2-5A PF06479.12 EFA80390.1 - 0.003 17.7 0.4 0.26 11.5 0.3 2.7 2 0 0 2 2 2 1 Ribonuclease 2-5A Helicase_C_2 PF13307.6 EFA80390.1 - 0.0081 16.3 0.1 0.025 14.7 0.1 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain Fungal_trans PF04082.18 EFA80390.1 - 0.12 11.4 0.2 0.26 10.3 0.2 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain Ribosomal_L5e PF17144.4 EFA80391.1 - 7e-82 273.3 0.4 1.4e-81 272.3 0.4 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EFA80391.1 - 1.4e-27 96.4 8.8 1.4e-27 96.4 8.8 2.1 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.6 EFA80391.1 - 0.082 13.1 0.2 3.1 8.1 0.0 2.9 1 1 1 2 2 2 0 Threonine synthase N terminus MAT1 PF06391.13 EFA80392.1 - 1.9e-29 103.0 28.7 3.1e-29 102.3 28.7 1.3 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EFA80392.1 - 1.8e-08 34.2 3.2 4.2e-08 32.9 3.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA80392.1 - 0.0013 18.8 2.4 0.0027 17.7 2.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA80392.1 - 0.0054 16.6 5.7 0.011 15.5 5.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA80392.1 - 0.021 15.2 4.2 0.036 14.4 4.2 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EFA80392.1 - 0.024 14.6 4.9 0.047 13.7 4.9 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFA80392.1 - 0.063 13.1 3.5 0.11 12.4 3.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFA80392.1 - 0.15 12.2 3.8 0.084 13.0 1.3 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EFA80392.1 - 0.24 11.7 1.7 0.57 10.5 1.7 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFA80392.1 - 0.3 11.0 4.3 0.53 10.2 4.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Hamartin PF04388.12 EFA80392.1 - 0.71 8.5 12.3 0.78 8.3 12.3 1.1 1 0 0 1 1 1 0 Hamartin protein LIDHydrolase PF10230.9 EFA80394.1 - 1.7e-27 96.7 1.4 3.1e-27 95.8 1.4 1.6 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EFA80394.1 - 0.0015 17.8 0.0 0.0022 17.3 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 EFA80394.1 - 0.0064 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 EFA80394.1 - 0.01 15.6 1.4 0.017 14.8 0.2 2.0 2 1 0 2 2 2 0 PGAP1-like protein Abhydrolase_1 PF00561.20 EFA80394.1 - 0.022 14.4 0.1 0.21 11.2 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Aldedh PF00171.22 EFA80395.1 - 2.8e-127 425.0 0.0 3.4e-127 424.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_M28 PF04389.17 EFA80396.1 - 6.3e-10 39.1 0.0 1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 EFA80396.1 - 0.00026 20.5 0.0 0.00051 19.6 0.0 1.5 1 0 0 1 1 1 1 Nicastrin PIG-P PF08510.12 EFA80397.1 - 5.9e-37 126.3 6.2 5.9e-37 126.3 6.2 1.8 2 0 0 2 2 2 1 PIG-P DPM2 PF07297.12 EFA80397.1 - 0.066 13.5 11.3 0.12 12.7 11.3 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) P2X_receptor PF00864.19 EFA80398.1 - 6.2e-23 81.5 5.0 6.5e-13 48.5 0.4 2.4 2 1 0 2 2 2 2 ATP P2X receptor DUF3823_C PF18003.1 EFA80398.1 - 0.46 11.2 6.3 0.14 12.9 1.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3823_C) BRCT_2 PF16589.5 EFA80399.1 - 7e-09 36.0 0.1 4e-08 33.5 0.0 2.3 1 1 1 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA80399.1 - 2.7e-05 24.5 0.8 8.9e-05 22.8 0.4 2.1 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFA80399.1 - 0.0012 19.1 0.1 0.0012 19.1 0.1 2.7 3 1 0 3 3 3 1 DNA ligase 3 BRCT domain MAS20 PF02064.15 EFA80399.1 - 0.017 15.2 1.9 0.076 13.1 0.0 2.6 3 0 0 3 3 3 0 MAS20 protein import receptor PTCB-BRCT PF12738.7 EFA80399.1 - 0.023 14.6 1.4 0.049 13.6 1.4 1.5 1 0 0 1 1 1 0 twin BRCT domain NPR1_interact PF15699.5 EFA80399.1 - 0.19 12.4 8.3 0.081 13.6 4.5 2.2 2 0 0 2 2 2 0 NPR1 interacting Ig_GlcNase PF18368.1 EFA80400.1 - 0.067 13.3 0.2 23 5.2 0.0 2.7 3 0 0 3 3 3 0 Exo-beta-D-glucosaminidase Ig-fold domain DegV PF02645.16 EFA80401.1 - 0.2 10.9 0.0 0.21 10.9 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 Peptidase_M16_M PF16187.5 EFA80402.1 - 6.2e-43 147.1 2.3 6.2e-43 147.1 2.3 2.0 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EFA80402.1 - 1.7e-37 128.7 0.8 1.7e-37 128.7 0.8 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFA80402.1 - 3.5e-21 76.0 7.2 1.1e-10 41.8 0.7 3.6 3 0 0 3 3 3 3 Peptidase M16 inactive domain IPPT PF01715.17 EFA80402.1 - 0.041 13.7 1.2 0.13 12.1 0.1 2.3 2 1 0 2 2 2 0 IPP transferase Phage_antitermQ PF06530.12 EFA80402.1 - 0.059 13.3 0.9 0.2 11.6 0.1 2.3 2 0 0 2 2 2 0 Phage antitermination protein Q PYRIN PF02758.16 EFA80402.1 - 0.9 9.7 3.3 18 5.6 0.0 3.5 3 0 0 3 3 3 0 PAAD/DAPIN/Pyrin domain DUF1084 PF06454.11 EFA80403.1 - 3.8e-18 65.8 15.3 4.6e-17 62.3 14.6 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1084) Wzy_C_2 PF11846.8 EFA80403.1 - 0.38 10.6 3.8 21 4.9 0.0 2.7 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal Ank_2 PF12796.7 EFA80404.1 - 1.4e-08 35.2 4.2 0.26 11.9 0.0 5.0 4 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80404.1 - 0.016 15.7 3.3 83 4.3 0.0 7.1 8 0 0 8 8 8 0 Ankyrin repeat zf-C2HC5 PF06221.13 EFA80407.1 - 1.2e-15 57.3 7.7 2.1e-15 56.4 7.7 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type NAGidase PF07555.13 EFA80407.1 - 0.00029 20.3 0.1 0.0012 18.3 0.1 2.1 1 1 1 2 2 2 1 beta-N-acetylglucosaminidase DUF4358 PF14270.6 EFA80407.1 - 0.024 14.9 4.7 1 9.7 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4358) PWI PF01480.17 EFA80407.1 - 0.025 14.9 0.9 0.42 11.0 0.0 3.3 3 0 0 3 3 3 0 PWI domain Mucin PF01456.17 EFA80408.1 - 0.074 13.1 41.1 0.032 14.2 32.0 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein DASH_Duo1 PF08651.10 EFA80408.1 - 0.18 11.6 5.6 0.24 11.2 0.3 3.5 2 1 1 3 3 3 0 DASH complex subunit Duo1 FAD_binding_1 PF00667.20 EFA80409.1 - 1.9e-38 132.2 0.2 4e-38 131.2 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFA80409.1 - 5.2e-27 94.8 0.0 1.4e-26 93.4 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFA80409.1 - 6e-21 75.1 0.0 1.8e-20 73.6 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFA80409.1 - 0.00035 20.8 0.0 0.00084 19.6 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin domain NAD_binding_6 PF08030.12 EFA80409.1 - 0.0011 19.1 0.1 0.014 15.5 0.0 2.4 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DUF2532 PF10811.8 EFA80409.1 - 0.0036 17.3 0.9 0.0085 16.2 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2532) Abhydrolase_1 PF00561.20 EFA80410.1 - 2.1e-14 53.8 0.7 2.2e-13 50.4 0.7 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA80410.1 - 4.8e-11 42.4 0.0 7.5e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA80410.1 - 9.4e-11 42.7 0.0 1.2e-10 42.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1057 PF06342.12 EFA80410.1 - 0.023 13.8 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Esterase PF00756.20 EFA80410.1 - 0.083 12.5 0.2 0.33 10.5 0.1 1.9 2 1 0 2 2 2 0 Putative esterase Lipase_3 PF01764.25 EFA80410.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) ELP6 PF09807.9 EFA80411.1 - 1.7e-39 135.8 2.3 1.4e-20 73.8 1.1 2.0 2 0 0 2 2 2 2 Elongation complex protein 6 Elong_Iki1 PF10483.9 EFA80411.1 - 4.6e-09 36.2 0.1 8.8e-07 28.7 0.1 2.0 2 0 0 2 2 2 2 Elongator subunit Iki1 Transcrip_act PF04949.13 EFA80411.1 - 0.069 13.0 0.2 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 Transcriptional activator Sdh5 PF03937.16 EFA80412.1 - 5.6e-24 83.9 0.2 8e-24 83.4 0.2 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase FNIP PF05725.12 EFA80414.1 - 2.2e-08 34.2 0.0 0.0011 19.0 0.0 2.7 2 0 0 2 2 2 2 FNIP Repeat YokU PF14122.6 EFA80414.1 - 0.0073 16.3 1.5 0.9 9.6 0.1 2.4 2 0 0 2 2 2 2 YokU-like protein, putative antitoxin F-box_5 PF18511.1 EFA80414.1 - 0.026 14.1 0.4 0.061 12.9 0.4 1.6 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 EFA80414.1 - 0.034 14.0 0.8 0.094 12.6 0.5 1.9 2 0 0 2 2 2 0 F-box-like MetOD1 PF18546.1 EFA80414.1 - 0.066 13.2 1.1 0.15 12.0 0.2 1.9 2 0 0 2 2 2 0 Metanogen output domain 1 adh_short PF00106.25 EFA80415.1 - 2.6e-17 62.9 0.0 3.2e-09 36.5 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA80415.1 - 2.8e-11 43.5 0.0 7.9e-06 25.6 0.0 2.5 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase Polbeta PF18765.1 EFA80415.1 - 0.087 12.9 0.5 0.54 10.4 0.0 2.7 3 0 0 3 3 3 0 Polymerase beta, Nucleotidyltransferase CPSase_L_D2 PF02786.17 EFA80416.1 - 0.024 14.1 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain DEAD PF00270.29 EFA80417.1 - 5.1e-45 153.4 0.0 8.8e-45 152.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA80417.1 - 1.2e-24 86.8 0.0 2.5e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SPRY PF00622.28 EFA80417.1 - 1.1e-08 35.2 3.2 0.00025 21.1 0.9 3.0 2 1 1 3 3 3 2 SPRY domain ResIII PF04851.15 EFA80417.1 - 0.00076 19.5 0.0 0.075 13.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFA80417.1 - 0.011 15.9 0.5 0.053 13.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain UPF0515 PF15135.6 EFA80418.1 - 9.6e-12 44.8 12.8 9.6e-12 44.8 12.8 2.0 2 0 0 2 2 2 1 Uncharacterised protein UPF0515 Zn_ribbon_SprT PF17283.2 EFA80418.1 - 0.18 11.8 20.1 0.27 11.2 0.3 4.4 4 0 0 4 4 4 0 SprT-like zinc ribbon domain 5HT_transport_N PF03491.13 EFA80418.1 - 0.62 10.3 2.2 41 4.5 0.0 3.3 3 1 1 4 4 4 0 Serotonin (5-HT) neurotransmitter transporter, N-terminus PSII_Pbs27 PF13326.6 EFA80420.1 - 0.024 15.0 0.1 0.21 11.9 0.0 2.4 2 1 0 2 2 2 0 Photosystem II Pbs27 DUF5435 PF17503.2 EFA80420.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5435) DUF4231 PF14015.6 EFA80420.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Cytochrom_B561 PF03188.16 EFA80420.1 - 0.64 10.2 2.8 1.2 9.2 0.3 2.4 3 0 0 3 3 3 0 Eukaryotic cytochrome b561 CTP_transf_like PF01467.26 EFA80421.1 - 5.5e-40 136.9 0.0 3e-21 76.1 0.0 2.4 2 1 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EFA80421.1 - 0.0003 20.7 4.6 0.44 10.4 0.5 3.9 3 1 0 3 3 3 2 FAD synthetase Peptidase_M28 PF04389.17 EFA80422.1 - 7.3e-32 110.7 0.0 1.1e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFA80422.1 - 1.4e-05 25.0 0.0 3.6e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 EFA80422.1 - 4.9e-05 22.9 0.2 8.8e-05 22.1 0.2 1.4 1 0 0 1 1 1 1 Nicastrin Adenosine_kin PF04008.14 EFA80422.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Adenosine specific kinase Mucin PF01456.17 EFA80424.1 - 4.9 7.1 16.6 4.5 7.3 10.1 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein WASH-7_N PF14745.6 EFA80426.1 - 7.8e-201 668.5 6.2 1.2e-200 667.8 6.2 1.3 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal WASH-7_mid PF14744.6 EFA80426.1 - 2.9e-152 506.7 7.0 2.9e-152 506.7 7.0 1.8 2 0 0 2 2 2 1 WASH complex subunit 7 WASH-7_C PF14746.6 EFA80426.1 - 4.9e-62 208.7 4.0 1.2e-61 207.5 4.0 1.7 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Mating_N PF12731.7 EFA80426.1 - 0.076 13.1 0.3 1.4 9.1 0.0 2.7 2 0 0 2 2 2 0 Mating-type protein beta 1 Peptidase_C39_2 PF13529.6 EFA80427.1 - 1e-20 74.7 0.5 4.7e-09 36.9 0.1 2.1 1 1 0 2 2 2 2 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFA80427.1 - 0.006 16.6 0.1 0.36 10.8 0.0 2.3 2 0 0 2 2 2 1 Papain-like cysteine protease AvrRpt2 Peptidase_C39 PF03412.15 EFA80427.1 - 0.11 12.3 0.1 0.31 10.9 0.1 1.7 1 0 0 1 1 1 0 Peptidase C39 family LRR_6 PF13516.6 EFA80429.1 - 3.5e-10 39.1 22.7 0.028 14.5 0.0 10.2 11 0 0 11 11 11 4 Leucine Rich repeat LRR_4 PF12799.7 EFA80429.1 - 1.6e-05 25.1 19.7 0.47 11.0 0.0 8.1 7 3 0 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA80429.1 - 0.0026 17.5 20.7 0.011 15.5 0.0 7.4 5 3 1 6 6 6 2 Leucine rich repeat LRR_1 PF00560.33 EFA80429.1 - 0.065 13.8 14.2 92 4.2 1.3 9.4 10 1 0 10 10 10 0 Leucine Rich Repeat Ras PF00071.22 EFA80430.1 - 1.4e-45 154.8 0.5 1.6e-45 154.6 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA80430.1 - 8e-14 51.9 0.0 1.4e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA80430.1 - 1.8e-09 37.3 0.1 2.1e-09 37.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA80430.1 - 9.8e-07 28.5 0.3 7.6e-06 25.6 0.0 2.0 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA80430.1 - 3e-05 24.0 0.2 0.00059 19.8 0.1 2.2 1 1 1 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFA80430.1 - 0.0013 18.8 0.1 0.0023 18.0 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 EFA80430.1 - 0.014 15.4 0.1 0.026 14.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain Pro_isomerase PF00160.21 EFA80431.1 - 1.1e-41 142.8 0.1 2.2e-41 141.7 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EFA80431.1 - 3.2e-15 55.7 0.0 6.7e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_1 PF00561.20 EFA80432.1 - 2.9e-06 27.1 0.2 4.2e-05 23.3 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA80432.1 - 0.00014 21.2 0.0 0.00022 20.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Hydrolase_4 PF12146.8 EFA80433.1 - 5.6e-10 38.9 0.0 1e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA80433.1 - 1.4e-06 28.2 0.1 0.0002 21.1 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF3089 PF11288.8 EFA80433.1 - 0.072 12.6 0.0 0.43 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) Thioesterase PF00975.20 EFA80433.1 - 0.19 11.8 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 EFA80434.1 - 2.6e-07 30.2 0.0 4.7e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA80434.1 - 5.4e-07 29.5 0.1 8.6e-06 25.6 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold BRCT_2 PF16589.5 EFA80435.1 - 1.2e-15 57.6 1.0 1.4e-15 57.5 0.1 1.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA80435.1 - 6.5e-05 23.2 3.2 0.00013 22.3 0.4 2.5 2 2 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFA80435.1 - 0.016 15.2 0.1 0.029 14.3 0.1 1.5 1 0 0 1 1 1 0 twin BRCT domain TPR_12 PF13424.6 EFA80436.1 - 6.2e-95 311.6 25.1 2.1e-17 63.2 0.0 8.6 4 1 6 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 EFA80436.1 - 1.4e-46 155.1 6.7 5.9e-06 26.0 0.0 11.5 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 EFA80436.1 - 2e-42 141.3 43.2 9.8e-08 31.5 0.6 10.6 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 EFA80436.1 - 7.8e-39 128.7 33.1 1.2e-05 25.1 0.3 10.7 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 EFA80436.1 - 5.3e-33 110.4 43.8 6.8e-06 25.9 0.4 10.8 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_7 PF13176.6 EFA80436.1 - 3.1e-29 98.8 14.5 4.9e-05 23.1 0.0 9.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.6 EFA80436.1 - 4.4e-14 52.8 5.0 0.072 13.8 0.0 8.1 7 2 1 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA80436.1 - 1e-11 44.9 0.0 1.1e-05 24.9 0.0 3.5 1 1 3 4 4 4 2 MalT-like TPR region TPR_19 PF14559.6 EFA80436.1 - 1.6e-11 44.5 4.3 0.23 12.0 0.0 6.2 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFA80436.1 - 2e-11 43.7 5.5 16 6.7 0.0 9.6 8 2 2 10 10 9 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA80436.1 - 6.3e-08 32.5 22.0 1.2 9.7 0.0 10.2 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA80436.1 - 8.2e-08 32.4 19.5 3.6 8.4 0.2 8.9 9 0 0 9 9 8 1 Tetratricopeptide repeat DUF4062 PF13271.6 EFA80436.1 - 5.5e-07 29.9 0.0 1.9e-06 28.1 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) TPR_11 PF13414.6 EFA80436.1 - 1.1e-05 25.0 31.2 0.9 9.3 0.1 9.7 8 2 1 9 9 9 2 TPR repeat SNAP PF14938.6 EFA80436.1 - 1.8e-05 24.3 12.9 0.0061 16.0 2.5 4.1 1 1 3 4 4 4 3 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 EFA80436.1 - 0.0003 20.9 16.3 0.13 12.5 0.0 5.9 2 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 NACHT PF05729.12 EFA80436.1 - 0.00081 19.3 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFA80436.1 - 0.00099 19.5 0.0 0.0034 17.8 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain TPR_9 PF13371.6 EFA80436.1 - 0.0036 17.4 0.0 7.7 6.8 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Ribosomal_S7 PF00177.21 EFA80436.1 - 0.0069 16.0 0.1 0.56 9.9 0.0 3.8 3 2 0 3 3 3 1 Ribosomal protein S7p/S5e RsgA_GTPase PF03193.16 EFA80436.1 - 0.0074 16.2 0.1 0.056 13.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 EFA80436.1 - 0.012 15.2 0.0 0.046 13.2 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2225 PF09986.9 EFA80436.1 - 0.016 15.0 21.9 0.047 13.4 0.8 5.3 2 2 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 EFA80436.1 - 0.024 15.3 2.3 0.2 12.4 0.1 3.7 4 0 0 4 4 1 0 Sel1 repeat PPR PF01535.20 EFA80436.1 - 0.054 13.8 1.1 38 4.8 0.0 4.8 5 0 0 5 5 4 0 PPR repeat AAA_22 PF13401.6 EFA80436.1 - 0.054 13.8 0.0 0.19 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain SPO22 PF08631.10 EFA80436.1 - 0.13 11.7 5.9 0.98 8.8 0.0 4.0 2 1 2 4 4 4 0 Meiosis protein SPO22/ZIP4 like TPR_21 PF09976.9 EFA80436.1 - 0.17 11.6 4.5 0.62 9.7 0.1 3.6 2 2 3 5 5 5 0 Tetratricopeptide repeat-like domain Mob_Pre PF01076.19 EFA80436.1 - 0.28 11.0 0.0 0.28 11.0 0.0 4.1 6 0 0 6 6 4 0 Plasmid recombination enzyme MIT PF04212.18 EFA80436.1 - 0.32 11.1 18.2 8.8 6.5 0.0 6.7 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain Apis_Csd PF11671.8 EFA80436.1 - 0.33 10.9 7.0 0.92 9.5 7.0 1.7 1 0 0 1 1 1 0 Complementary sex determiner protein Fis1_TPR_C PF14853.6 EFA80436.1 - 0.92 9.6 7.9 23 5.2 0.1 5.3 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Arm_3 PF16186.5 EFA80436.1 - 2.1 8.0 15.8 1.8 8.2 0.0 5.6 6 0 0 6 6 4 0 Atypical Arm repeat CPBP PF02517.16 EFA80437.1 - 8.2e-09 35.7 1.9 9.3e-09 35.6 0.3 1.7 1 1 1 2 2 2 1 CPBP intramembrane metalloprotease PA14 PF07691.12 EFA80438.1 - 0.033 14.0 0.1 0.066 13.0 0.1 1.5 1 0 0 1 1 1 0 PA14 domain DUF2613 PF11021.8 EFA80438.1 - 0.16 12.1 3.2 0.37 10.9 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) PTP2 PF17022.5 EFA80439.1 - 0.068 12.8 0.1 3.9 7.0 0.1 2.1 2 0 0 2 2 2 0 Polar tube protein 2 from Microsporidia ING PF12998.7 EFA80439.1 - 0.15 12.7 1.6 6.3 7.4 0.7 2.7 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Vac_ImportDeg PF09783.9 EFA80440.1 - 4.2e-60 202.2 4.4 1.3e-59 200.7 4.4 1.8 1 0 0 1 1 1 1 Vacuolar import and degradation protein tRNA-synt_2b PF00587.25 EFA80440.1 - 3.4e-41 141.2 0.2 3.8e-40 137.8 0.2 2.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFA80440.1 - 0.00095 19.3 0.0 0.0026 17.9 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain Thioredoxin_16 PF18569.1 EFA80440.1 - 0.28 11.3 4.2 0.2 11.8 1.9 1.9 2 0 0 2 2 2 0 Thioredoxin-like domain EF1_GNE PF00736.19 EFA80441.1 - 1.4e-33 114.9 0.4 3.1e-33 113.8 0.4 1.6 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EFA80441.1 - 0.0002 21.8 7.1 0.00062 20.1 7.1 1.9 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_6 PF17171.4 EFA80441.1 - 0.0025 17.6 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA80441.1 - 0.0097 15.9 0.0 0.031 14.3 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA80441.1 - 0.044 14.0 3.0 0.082 13.1 0.1 2.7 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain NOP5NT PF08156.13 EFA80441.1 - 0.16 12.4 1.0 0.36 11.2 0.0 2.0 3 1 0 3 3 3 0 NOP5NT (NUC127) domain LPD22 PF18834.1 EFA80441.1 - 5.2 7.3 7.6 1 9.6 3.1 2.2 2 1 0 2 2 2 0 Large polyvalent protein associated domain 22 Acyltransferase PF01553.21 EFA80442.1 - 4.5e-11 42.5 0.0 9.7e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Sugarporin_N PF11471.8 EFA80444.1 - 0.009 15.9 0.0 0.009 15.9 0.0 1.8 2 0 0 2 2 2 1 Maltoporin periplasmic N-terminal extension CENP-F_N PF10481.9 EFA80444.1 - 0.044 13.4 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Cenp-F N-terminal domain DUF1192 PF06698.11 EFA80444.1 - 0.093 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF2674 PF10879.8 EFA80445.1 - 0.14 11.8 0.4 0.14 11.8 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2674) Ribosomal_L24e PF01246.20 EFA80446.1 - 0.15 12.3 0.6 0.38 11.0 0.6 1.7 1 0 0 1 1 1 0 Ribosomal protein L24e Pkinase PF00069.25 EFA80447.1 - 3.2e-72 243.1 1.3 4.9e-72 242.5 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80447.1 - 2.4e-45 154.8 0.0 4.5e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA80447.1 - 9.8e-06 25.1 0.0 3.5e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFA80447.1 - 0.00092 18.1 1.4 0.0027 16.6 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase SF-assemblin PF06705.11 EFA80447.1 - 0.0052 16.2 1.8 0.0052 16.2 1.8 2.8 2 1 1 3 3 3 1 SF-assemblin/beta giardin APH PF01636.23 EFA80447.1 - 0.0061 16.5 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFA80447.1 - 0.026 14.2 0.4 0.77 9.3 0.0 2.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PX PF00787.24 EFA80448.1 - 1.8e-10 40.8 0.3 1.8e-10 40.8 0.3 2.8 3 1 0 3 3 3 1 PX domain V-SNARE PF05008.15 EFA80449.1 - 8.3e-05 22.9 1.3 0.00013 22.2 1.1 1.5 1 1 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus Phage_int_SAM_6 PF18644.1 EFA80449.1 - 0.059 13.4 0.2 0.098 12.7 0.2 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain HlyIII PF03006.20 EFA80450.1 - 2.7e-22 79.6 12.8 4e-22 79.0 12.8 1.2 1 0 0 1 1 1 1 Haemolysin-III related Beach PF02138.18 EFA80451.1 - 8.3e-121 402.6 0.4 2.3e-120 401.1 0.4 1.8 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EFA80451.1 - 1.3e-13 50.9 1.2 1.4e-12 47.6 0.0 3.2 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EFA80451.1 - 1.3e-08 35.3 18.9 0.0069 17.2 1.7 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat tRNA-synt_2b PF00587.25 EFA80453.1 - 4.3e-36 124.6 0.0 6.6e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFA80453.1 - 1.3e-17 64.0 1.9 1.3e-17 64.0 1.9 2.1 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Uds1 PF15456.6 EFA80453.1 - 0.02 15.1 1.2 0.05 13.8 1.2 1.6 1 0 0 1 1 1 0 Up-regulated During Septation PI3K_P85_iSH2 PF16454.5 EFA80453.1 - 0.23 11.1 3.0 0.14 11.8 0.3 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SNARE PF05739.19 EFA80454.1 - 3.2e-07 30.2 7.1 4.7e-07 29.7 2.2 2.8 3 0 0 3 3 3 1 SNARE domain Use1 PF09753.9 EFA80454.1 - 0.00014 21.7 9.7 0.00021 21.1 9.8 1.3 1 0 0 1 1 1 1 Membrane fusion protein Use1 EVI2A PF05399.11 EFA80454.1 - 0.0014 18.3 4.4 0.0018 17.9 3.7 1.5 1 1 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) Sh_2 PF17512.2 EFA80454.1 - 0.062 13.1 1.1 0.11 12.3 0.5 1.6 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein Prominin PF05478.11 EFA80454.1 - 0.11 10.4 14.0 0.022 12.8 3.0 2.0 2 0 0 2 2 2 0 Prominin CAC1F_C PF16885.5 EFA80454.1 - 0.27 10.9 5.2 0.32 10.6 5.2 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Syntaxin-6_N PF09177.11 EFA80454.1 - 0.44 11.1 7.5 0.093 13.3 0.8 2.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Phage_Gp23 PF10669.9 EFA80454.1 - 6.9 7.0 11.4 0.33 11.3 2.0 2.9 3 1 0 3 3 3 0 Protein gp23 (Bacteriophage A118) EphA2_TM PF14575.6 EFA80455.1 - 0.18 12.7 0.2 0.42 11.5 0.2 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ank_4 PF13637.6 EFA80456.1 - 5.4e-16 58.7 2.8 0.0044 17.6 0.0 6.6 6 2 0 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80456.1 - 2.5e-15 56.8 5.7 6.3e-05 23.5 0.0 4.8 2 2 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80456.1 - 3e-10 39.4 4.1 0.0048 17.3 0.0 7.8 8 1 1 9 9 9 2 Ankyrin repeat Ank_5 PF13857.6 EFA80456.1 - 1.5e-07 31.6 2.4 3.9 7.9 0.1 6.2 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Evr1_Alr PF04777.13 EFA80456.1 - 0.0052 17.2 1.0 0.015 15.7 1.0 1.7 1 0 0 1 1 1 1 Erv1 / Alr family Ank_4 PF13637.6 EFA80458.1 - 6.2e-22 77.7 3.0 0.0022 18.5 0.0 6.3 4 3 2 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80458.1 - 5e-20 71.9 4.4 9.4e-06 26.1 0.0 5.9 4 1 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80458.1 - 2.2e-13 49.1 6.0 0.0017 18.7 0.0 9.1 9 0 0 9 9 9 2 Ankyrin repeat Ank_5 PF13857.6 EFA80458.1 - 8e-13 48.3 7.5 0.024 15.0 0.1 7.4 4 1 5 9 9 9 3 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA80458.1 - 0.0016 18.2 0.4 0.0016 18.2 0.4 3.4 3 2 2 5 5 5 1 Multigene family 530 protein G8 PF10162.9 EFA80459.1 - 1.6e-26 92.8 0.2 5.9e-26 90.9 0.2 2.1 1 0 0 1 1 1 1 G8 domain Peptidase_M28 PF04389.17 EFA80460.1 - 1.6e-20 73.6 0.3 1.3e-19 70.7 0.3 2.2 1 1 0 1 1 1 1 Peptidase family M28 Ras PF00071.22 EFA80461.1 - 9e-51 171.7 2.3 5.1e-37 127.0 0.0 3.2 3 0 0 3 3 3 2 Ras family Roc PF08477.13 EFA80461.1 - 3.3e-20 72.5 0.1 8.3e-12 45.4 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA80461.1 - 5.7e-08 32.4 0.6 0.0001 21.8 0.0 3.3 3 1 1 4 4 4 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA80461.1 - 1.5e-05 24.6 0.0 3.4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA80461.1 - 0.00024 21.0 0.0 0.0006 19.8 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase VWA_2 PF13519.6 EFA80461.1 - 0.00031 21.4 0.0 0.048 14.3 0.0 3.3 1 1 0 1 1 1 1 von Willebrand factor type A domain Sec23_BS PF08033.12 EFA80461.1 - 0.0026 18.4 0.7 0.0093 16.7 0.7 2.0 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain MMR_HSR1 PF01926.23 EFA80461.1 - 0.004 17.2 0.0 1.6 8.8 0.0 3.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase zf-Sec23_Sec24 PF04810.15 EFA80461.1 - 0.0059 16.6 5.7 0.013 15.5 5.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_trunk PF04811.15 EFA80461.1 - 0.011 15.3 0.0 0.45 10.1 0.0 2.6 1 1 0 1 1 1 0 Sec23/Sec24 trunk domain DUF2076 PF09849.9 EFA80461.1 - 0.019 15.0 0.1 0.032 14.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) TniB PF05621.11 EFA80461.1 - 0.089 12.2 0.0 0.27 10.6 0.0 1.8 1 0 0 1 1 1 0 Bacterial TniB protein HOIP-UBA PF16678.5 EFA80461.1 - 0.11 12.5 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 HOIP UBA domain pair MaoC_dehydratas PF01575.19 EFA80462.1 - 4.9e-22 77.8 0.0 1.3e-21 76.4 0.0 1.8 1 1 1 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EFA80462.1 - 4.4e-05 23.6 0.0 6.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase DUF1451 PF07295.11 EFA80462.1 - 0.14 12.2 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain JAB PF01398.21 EFA80464.1 - 2.4e-21 75.9 0.1 2.4e-21 75.9 0.1 2.7 3 0 0 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 EFA80464.1 - 2.8e-17 63.0 2.2 2.8e-17 63.0 2.2 3.1 4 0 0 4 4 4 1 USP8 dimerisation domain Prok-JAB PF14464.6 EFA80464.1 - 3.2e-05 23.7 0.9 9.6e-05 22.1 0.0 2.2 2 1 0 2 2 2 1 Prokaryotic homologs of the JAB domain Myb_DNA-binding PF00249.31 EFA80465.1 - 3.4e-05 23.9 0.1 9.6e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain GATA PF00320.27 EFA80465.1 - 0.00028 20.4 3.6 0.00064 19.3 3.6 1.6 1 0 0 1 1 1 1 GATA zinc finger DEAD PF00270.29 EFA80466.1 - 2.4e-21 76.3 0.0 2e-20 73.3 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA80466.1 - 6.6e-19 68.3 0.1 2e-16 60.3 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EFA80466.1 - 2.3e-10 41.0 4.7 2.4e-10 41.0 1.9 2.7 2 0 0 2 2 2 1 RecQ zinc-binding EGF_CA PF07645.15 EFA80467.1 - 4.6e-53 177.2 169.6 1.5e-08 34.7 11.6 11.0 10 1 0 10 10 10 8 Calcium-binding EGF domain cEGF PF12662.7 EFA80467.1 - 7.5e-39 131.3 89.3 2.2e-07 30.7 1.4 11.2 10 0 0 10 10 10 8 Complement Clr-like EGF-like EGF_3 PF12947.7 EFA80467.1 - 3.3e-19 68.8 135.9 6.6e-05 23.0 8.1 12.2 7 2 3 10 10 10 9 EGF domain FXa_inhibition PF14670.6 EFA80467.1 - 1.2e-13 51.0 139.6 0.00034 20.8 3.4 10.7 9 2 2 11 11 11 9 Coagulation Factor Xa inhibitory site EGF PF00008.27 EFA80467.1 - 7.2e-11 42.2 145.1 0.0022 18.2 6.7 12.1 11 2 0 11 11 11 8 EGF-like domain hEGF PF12661.7 EFA80467.1 - 0.00058 20.4 133.8 0.05 14.2 2.5 12.9 11 2 0 11 11 11 7 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 EFA80467.1 - 0.0047 17.0 87.7 0.081 13.0 4.2 9.3 7 1 1 8 8 8 6 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 EFA80467.1 - 1.7 9.0 149.6 0.11 12.9 6.5 10.4 9 1 1 10 10 10 0 Pvs28 EGF domain GST_N_3 PF13417.6 EFA80468.1 - 3.4e-10 40.2 0.0 1.1e-09 38.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA80468.1 - 5e-07 29.7 0.2 1.1e-06 28.6 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA80468.1 - 2.3e-05 24.1 0.6 0.00011 21.9 0.2 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA80468.1 - 3.8e-05 23.9 0.1 0.00024 21.4 0.1 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA80468.1 - 0.00012 22.2 0.0 0.00026 21.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA80468.1 - 0.00019 21.6 0.1 0.00072 19.7 0.1 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EFA80468.1 - 0.0094 16.5 0.0 1.9 9.1 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain FNIP PF05725.12 EFA80469.1 - 1.8e-30 104.8 16.1 5.6e-12 45.6 0.4 8.2 4 2 5 9 9 9 7 FNIP Repeat E2F_CC-MB PF16421.5 EFA80469.1 - 0.11 12.8 0.1 0.33 11.4 0.1 1.7 1 0 0 1 1 1 0 E2F transcription factor CC-MB domain Pentapeptide_4 PF13599.6 EFA80470.1 - 1.4 9.1 13.3 0.63 10.2 7.0 3.4 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) Guanylate_kin PF00625.21 EFA80471.1 - 7.5e-50 169.1 0.0 9.6e-50 168.8 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase Ras PF00071.22 EFA80472.1 - 9.2e-17 61.1 0.3 1.2e-14 54.2 0.2 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFA80472.1 - 1.9e-13 50.7 0.1 4e-13 49.6 0.1 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA80472.1 - 2e-07 30.6 0.1 1.2e-05 24.8 0.1 2.0 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA80472.1 - 3.3e-05 23.4 0.1 3.3e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA80472.1 - 0.0023 18.0 0.1 0.0026 17.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA80472.1 - 0.0038 16.7 0.1 0.0055 16.2 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFA80472.1 - 0.018 14.9 0.3 0.34 10.8 0.1 2.1 1 1 1 2 2 2 0 RsgA GTPase MnmE_helical PF12631.7 EFA80472.1 - 0.12 12.6 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 MnmE helical domain ICL PF00463.21 EFA80473.1 - 2e-106 356.6 0.3 1e-54 186.0 0.0 2.1 1 1 1 2 2 2 2 Isocitrate lyase family PEP_mutase PF13714.6 EFA80473.1 - 1.1e-14 54.5 0.0 1.9e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Not3 PF04065.15 EFA80474.1 - 1.7e-74 250.2 23.1 1.7e-74 250.2 23.1 2.1 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EFA80474.1 - 5.8e-38 129.9 10.2 5.8e-38 129.9 10.2 4.0 4 2 0 4 4 4 1 NOT2 / NOT3 / NOT5 family Mei5_like PF17021.5 EFA80474.1 - 0.0058 16.7 0.4 0.0058 16.7 0.4 3.4 3 0 0 3 3 3 1 Putative double-strand recombination repair-like DUF4407 PF14362.6 EFA80474.1 - 7.8 5.8 18.5 6.3 6.1 5.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Chlam_PMP PF02415.17 EFA80475.1 - 3.1 8.4 76.0 1.2 9.7 1.3 10.8 11 1 0 11 11 11 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pkinase PF00069.25 EFA80476.1 - 6.4e-61 206.0 0.0 1.2e-60 205.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80476.1 - 1.6e-23 83.3 0.0 3e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA80476.1 - 0.0011 18.3 0.0 0.0025 17.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFA80476.1 - 0.052 12.9 0.7 0.085 12.2 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFA80476.1 - 0.35 9.6 0.0 0.35 9.6 0.0 2.1 2 1 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 EFA80476.1 - 0.36 10.4 0.0 0.36 10.4 0.0 2.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 HATPase_c PF02518.26 EFA80477.1 - 1e-29 103.3 0.0 2.2e-29 102.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA80477.1 - 1.7e-21 76.5 0.0 3.4e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFA80477.1 - 1.3e-18 66.8 0.1 3.6e-18 65.3 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Mucin PF01456.17 EFA80477.1 - 4.4 7.3 16.9 0.5 10.4 12.2 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein RtcB PF01139.17 EFA80478.1 - 5.1e-149 496.9 0.0 6e-149 496.7 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB C2 PF00168.30 EFA80480.1 - 4.3e-25 88.0 0.3 1.4e-24 86.3 0.3 2.0 1 0 0 1 1 1 1 C2 domain DUF1759 PF03564.15 EFA80480.1 - 0.068 13.1 0.3 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) Vault PF01505.18 EFA80481.1 - 3e-67 222.6 0.8 1.4e-15 57.2 0.0 5.7 6 0 0 6 6 6 4 Major Vault Protein repeat domain MVP_shoulder PF11978.8 EFA80481.1 - 7.6e-50 167.9 0.9 1.4e-49 167.0 0.9 1.5 1 0 0 1 1 1 1 Shoulder domain Vault_2 PF17794.1 EFA80481.1 - 2.8e-37 126.9 0.1 5.7e-24 84.3 0.1 2.7 2 0 0 2 2 2 2 Major Vault Protein repeat domain Vault_3 PF17795.1 EFA80481.1 - 4.4e-34 116.3 0.2 4.3e-30 103.6 0.0 3.5 3 0 0 3 3 3 2 Major Vault Protein Repeat domain Vault_4 PF17796.1 EFA80481.1 - 1.6e-21 76.2 0.3 8e-21 73.9 0.1 2.4 2 0 0 2 2 2 1 Major Vault Protein repeat domain DUF3601 PF12208.8 EFA80481.1 - 0.0014 18.7 0.0 0.53 10.4 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3601) DAAD PF18752.1 EFA80481.1 - 0.28 11.0 1.2 0.51 10.1 1.2 1.5 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase HVSL PF09749.9 EFA80482.1 - 7.8e-39 133.6 0.1 1.2e-38 132.9 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 EFA80482.1 - 0.0032 17.4 0.0 0.0079 16.1 0.0 1.6 1 1 1 2 2 2 1 2'-5' RNA ligase superfamily Viral_DNA_bp PF00747.17 EFA80482.1 - 0.0059 13.8 0.1 0.0076 13.5 0.1 1.1 1 0 0 1 1 1 1 ssDNA binding protein Mei5 PF10376.9 EFA80482.1 - 0.028 14.3 0.6 0.063 13.1 0.6 1.5 1 0 0 1 1 1 0 Double-strand recombination repair protein LigT_PEase PF02834.16 EFA80482.1 - 0.14 12.4 0.0 0.43 10.8 0.0 1.8 2 0 0 2 2 2 0 LigT like Phosphoesterase COX14 PF14880.6 EFA80483.1 - 0.033 14.0 0.8 0.095 12.6 0.8 1.7 1 0 0 1 1 1 0 Cytochrome oxidase c assembly MIF4G_like_2 PF09090.11 EFA80484.1 - 1.5e-34 119.7 3.9 1.5e-34 119.7 3.9 2.1 2 0 0 2 2 2 1 MIF4G like MIF4G_like PF09088.11 EFA80484.1 - 2e-23 83.2 2.9 1.3e-22 80.6 2.7 2.3 1 1 1 2 2 2 1 MIF4G like MIF4G PF02854.19 EFA80484.1 - 1.8e-15 57.2 5.1 1.8e-15 57.2 5.1 3.1 4 0 0 4 4 4 1 MIF4G domain RSN1_7TM PF02714.15 EFA80485.1 - 0.039 13.3 0.1 0.065 12.5 0.1 1.4 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate PspB PF06667.12 EFA80485.1 - 0.073 13.1 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 Phage shock protein B F-box-like PF12937.7 EFA80486.1 - 0.0075 16.1 0.2 0.023 14.6 0.2 1.8 1 0 0 1 1 1 1 F-box-like DUF3697 PF12478.8 EFA80486.1 - 0.16 12.1 0.0 0.6 10.3 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-associated protein 2 DDE_3 PF13358.6 EFA80487.1 - 1.7e-11 44.1 0.0 2.1e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.6 EFA80487.1 - 6.3e-09 35.8 0.8 1.3e-08 34.8 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 EFA80487.1 - 1.1e-07 31.4 0.1 7.9e-07 28.7 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EFA80487.1 - 3.3e-07 30.2 0.3 5.6e-07 29.5 0.3 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.6 EFA80487.1 - 3.9e-05 23.3 0.2 0.00011 21.9 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 EFA80487.1 - 7.6e-05 23.2 0.1 0.00015 22.3 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4 PF04545.16 EFA80487.1 - 7.8e-05 22.1 0.1 0.00018 21.0 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 PAX PF00292.18 EFA80487.1 - 0.00054 19.9 0.1 0.00079 19.3 0.1 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_AsnC-type PF13404.6 EFA80487.1 - 0.0027 17.5 0.0 0.007 16.2 0.0 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 EFA80487.1 - 0.0029 17.6 0.0 0.88 9.7 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 EFA80487.1 - 0.0071 16.4 0.2 0.01 15.9 0.2 1.3 1 0 0 1 1 1 1 Transposase GcrA PF07750.11 EFA80487.1 - 0.01 16.3 0.0 0.012 16.0 0.0 1.1 1 0 0 1 1 1 0 GcrA cell cycle regulator MarR_2 PF12802.7 EFA80487.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.12 EFA80487.1 - 0.017 15.0 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 HTH domain HTH_50 PF18024.1 EFA80487.1 - 0.027 14.1 0.0 0.052 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 EFA80487.1 - 0.035 13.7 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_Tnp_4 PF13613.6 EFA80487.1 - 0.041 13.6 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 1 0 Helix-turn-helix of DDE superfamily endonuclease MarR PF01047.22 EFA80487.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 MarR family Sigma70_r4_2 PF08281.12 EFA80487.1 - 0.13 11.9 0.0 0.37 10.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_30 PF13556.6 EFA80487.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Pou PF00157.17 EFA80487.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Fer2_BFD PF04324.15 EFA80487.1 - 0.14 12.5 0.2 4.4 7.7 0.0 2.8 3 0 0 3 3 3 0 BFD-like [2Fe-2S] binding domain IBN_N PF03810.19 EFA80488.1 - 9.2e-09 35.1 4.9 1.3e-08 34.7 1.7 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFA80488.1 - 0.0011 19.1 0.3 0.0011 19.1 0.3 4.2 5 2 0 5 5 5 1 Exportin 1-like protein MOR2-PAG1_C PF14225.6 EFA80488.1 - 0.0073 16.2 1.1 0.043 13.7 0.0 2.6 2 1 0 2 2 2 1 Cell morphogenesis C-terminal UCH PF00443.29 EFA80488.1 - 0.014 14.9 1.1 0.12 11.9 0.0 2.7 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.22 EFA80489.1 - 6.3e-16 58.0 0.0 8.3e-16 57.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA80489.1 - 0.00043 20.3 0.0 0.001 19.1 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EFA80489.1 - 0.0008 19.4 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EFA80489.1 - 0.0034 17.6 0.1 0.014 15.6 0.1 1.8 1 1 1 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter Complex1_LYR PF05347.15 EFA80490.1 - 5.4e-08 32.8 0.0 7.1e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFA80490.1 - 0.012 16.3 0.0 0.013 16.2 0.0 1.1 1 0 0 1 1 1 0 Complex1_LYR-like RhoGEF PF00621.20 EFA80491.1 - 4.1e-42 144.5 5.9 4.1e-42 144.5 5.9 3.9 4 1 0 4 4 4 1 RhoGEF domain MOZ_SAS PF01853.18 EFA80491.1 - 1.3e-34 119.5 0.0 1e-33 116.5 0.0 2.4 2 0 0 2 2 2 1 MOZ/SAS family Titin_Z PF09042.11 EFA80491.1 - 0.024 14.6 2.2 0.17 11.9 2.2 2.7 1 0 0 1 1 1 0 Titin Z IQ PF00612.27 EFA80491.1 - 0.052 13.4 0.2 0.21 11.5 0.2 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Myb_DNA-binding PF00249.31 EFA80492.1 - 2.8e-31 107.5 8.7 1.1e-13 51.1 0.9 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA80492.1 - 3.8e-26 91.1 6.3 7.2e-13 48.6 0.2 3.9 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFA80492.1 - 0.00017 21.9 17.9 0.00032 21.0 0.2 4.7 5 0 0 5 5 5 2 Myb/SANT-like DNA-binding domain DUF3500 PF12006.8 EFA80492.1 - 0.00069 19.2 2.2 0.0014 18.2 2.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) VGLL4 PF15245.6 EFA80492.1 - 0.13 12.4 4.2 0.11 12.6 1.1 2.3 2 1 0 2 2 2 0 Transcription cofactor vestigial-like protein 4 MADF_DNA_bdg PF10545.9 EFA80492.1 - 0.14 12.5 15.0 1.2 9.5 0.1 4.7 4 1 1 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Dehydrin PF00257.19 EFA80492.1 - 1.5 9.3 7.4 0.18 12.4 2.8 1.8 2 0 0 2 2 2 0 Dehydrin FCP1_C PF09309.10 EFA80492.1 - 1.7 8.5 12.1 0.088 12.7 6.6 1.7 2 0 0 2 2 2 0 FCP1, C-terminal DUF722 PF05263.11 EFA80492.1 - 2.9 8.1 7.9 0.6 10.3 0.1 3.4 3 2 1 4 4 4 0 Protein of unknown function (DUF722) DUF1296 PF06972.11 EFA80492.1 - 4.1 7.6 8.2 7 6.9 2.7 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1296) Nucleoporin_N PF08801.11 EFA80493.1 - 3.3e-49 167.8 4.8 3.3e-49 167.8 4.8 1.9 2 0 0 2 2 2 1 Nup133 N terminal like DUF4522 PF15022.6 EFA80493.1 - 0.0009 19.5 0.5 0.0035 17.6 0.5 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4522) ING PF12998.7 EFA80494.1 - 0.12 12.9 0.2 4.5 7.9 0.2 2.3 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding CG-1 PF03859.16 EFA80495.1 - 0.068 13.0 0.6 0.26 11.1 0.1 2.1 2 1 0 2 2 2 0 CG-1 domain PIGA PF08288.12 EFA80496.1 - 2e-44 150.1 0.6 2e-44 150.1 0.6 2.1 3 0 0 3 3 3 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EFA80496.1 - 1e-28 100.4 0.0 1.7e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EFA80496.1 - 2.4e-26 92.3 0.1 3.7e-26 91.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA80496.1 - 1.3e-22 80.7 0.0 2.4e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFA80496.1 - 1.1e-09 39.0 0.0 1.9e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EFA80496.1 - 2e-06 27.9 0.1 3.6e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EFA80496.1 - 0.025 14.9 0.0 0.078 13.4 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EFA80496.1 - 0.041 13.6 0.2 0.18 11.5 0.2 2.0 1 1 0 1 1 1 0 Starch synthase catalytic domain EF-hand_1 PF00036.32 EFA80497.1 - 2.4e-17 61.1 6.5 4.4e-06 25.8 0.2 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFA80497.1 - 1.2e-15 56.0 4.0 3.5e-05 23.4 0.0 3.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFA80497.1 - 2.8e-15 55.0 9.1 3.1e-05 23.3 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFA80497.1 - 9.6e-15 54.8 1.6 8.8e-09 35.7 0.5 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA80497.1 - 4.4e-11 42.5 6.8 6.7e-06 25.9 0.3 3.2 3 0 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA80497.1 - 1.2e-09 38.5 1.7 0.0015 18.9 0.0 2.8 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EFA80497.1 - 3.3e-05 24.0 0.5 0.2 11.9 0.1 2.3 2 1 0 2 2 2 2 Dockerin type I domain EF-hand_9 PF14658.6 EFA80497.1 - 4.7e-05 23.6 0.1 0.0001 22.5 0.0 1.6 1 1 1 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 EFA80497.1 - 0.00077 19.4 5.6 0.5 10.3 0.1 3.1 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand VCBS PF13517.6 EFA80497.1 - 0.02 15.5 0.3 14 6.3 0.0 2.9 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PWI PF01480.17 EFA80498.1 - 2e-15 56.9 1.1 2e-15 56.9 1.1 2.5 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 EFA80498.1 - 1.1e-10 41.2 0.0 2.6e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 EFA80498.1 - 0.0025 17.9 21.7 0.0025 17.9 21.7 2.9 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit TCP PF03634.13 EFA80498.1 - 0.46 11.0 0.0 0.46 11.0 0.0 5.4 2 1 2 5 5 5 0 TCP family transcription factor TPR_17 PF13431.6 EFA80499.1 - 1.2e-121 388.7 17.3 2.3e-10 40.1 0.1 13.5 14 0 0 14 14 13 12 Tetratricopeptide repeat TPR_11 PF13414.6 EFA80499.1 - 3.2e-27 93.9 30.6 0.0036 16.9 0.2 12.1 13 0 0 13 13 13 8 TPR repeat Anth_Ig PF05587.13 EFA80499.1 - 2.1e-06 28.0 11.5 26 5.2 0.0 8.8 10 0 0 10 10 9 0 Anthrax receptor extracellular domain DUF2155 PF09923.9 EFA80499.1 - 5.7e-06 26.5 3.0 60 4.0 0.0 7.5 3 3 5 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2155) DUF3255 PF11631.8 EFA80499.1 - 0.0033 17.3 5.0 3 7.7 0.1 5.9 3 2 5 8 8 8 1 Protein of unknown function (DUF3255) Glyco_hydro_61 PF03443.14 EFA80499.1 - 0.0033 17.4 0.4 4.9 7.0 0.0 4.1 3 2 1 4 4 4 1 Glycosyl hydrolase family 61 DUF4261 PF14080.6 EFA80499.1 - 0.041 14.0 2.4 1e+02 3.1 0.0 5.8 8 0 0 8 8 7 0 Domain of unknown function (DUF4261) DUF1344 PF07076.11 EFA80499.1 - 0.07 13.0 16.2 6.8 6.7 0.0 8.1 10 1 0 10 10 10 0 Protein of unknown function (DUF1344) Tudor_RapA PF18337.1 EFA80499.1 - 0.15 12.3 3.3 29 4.9 0.0 5.2 6 0 0 6 6 6 0 RapA N-terminal Tudor like domain DUF4988 PF16378.5 EFA80499.1 - 0.17 11.5 11.9 9.7 5.8 0.1 6.7 3 2 3 8 8 8 0 Domain of unknown function gerPA PF10676.9 EFA80499.1 - 0.21 11.9 4.4 70 3.8 0.1 5.2 5 0 0 5 5 5 0 Spore germination protein gerPA/gerPF NleF_casp_inhib PF16809.5 EFA80499.1 - 0.47 10.3 6.7 1.1e+02 2.7 0.0 6.1 5 2 3 8 8 8 0 NleF caspase inhibitor CLIP PF12032.8 EFA80499.1 - 0.65 10.3 8.7 23 5.4 0.3 6.1 7 1 0 7 7 7 0 Regulatory CLIP domain of proteinases HCBP_related PF06594.11 EFA80499.1 - 0.75 9.8 2.9 28 4.7 0.0 4.9 7 0 0 7 7 7 0 Haemolysin-type calcium binding protein related domain preSET_CXC PF18264.1 EFA80499.1 - 1.6 9.3 7.5 53 4.4 0.1 5.8 8 0 0 8 8 8 0 CXC domain RasGEF PF00617.19 EFA80500.1 - 1.1e-25 90.9 0.0 1.4e-24 87.2 0.0 2.0 2 0 0 2 2 2 1 RasGEF domain T4-Gluco-transf PF09198.10 EFA80500.1 - 0.21 11.2 2.3 0.79 9.4 2.3 1.9 1 1 0 1 1 1 0 Bacteriophage T4 beta-glucosyltransferase RasGEF_N PF00618.20 EFA80501.1 - 2.1e-19 69.7 0.4 2.1e-19 69.7 0.4 6.3 7 1 0 7 7 7 1 RasGEF N-terminal motif RasGEF PF00617.19 EFA80501.1 - 7.7e-19 68.6 1.1 7.7e-19 68.6 1.1 2.5 2 0 0 2 2 2 1 RasGEF domain FERM_f0 PF16511.5 EFA80501.1 - 9e-12 45.1 2.5 4.8e-05 23.6 0.0 4.7 4 0 0 4 4 4 2 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 EFA80501.1 - 0.0022 17.9 0.1 0.92 9.5 0.1 3.1 3 0 0 3 3 3 2 FERM N-terminal domain O-antigen_lig PF13425.6 EFA80502.1 - 1e-07 31.1 0.4 1.2e-07 30.9 0.4 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein PQ-loop PF04193.14 EFA80502.1 - 1.4e-06 27.9 4.1 1.4e-06 27.9 4.1 3.0 1 1 1 2 2 2 1 PQ loop repeat Peptidase_M50B PF13398.6 EFA80502.1 - 0.012 15.2 0.5 0.018 14.7 0.5 1.2 1 0 0 1 1 1 0 Peptidase M50B-like DUF996 PF06195.13 EFA80502.1 - 0.022 15.1 1.5 0.035 14.4 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF996) Bax1-I PF01027.20 EFA80502.1 - 0.023 14.5 5.8 0.032 14.1 5.8 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 EamA PF00892.20 EFA80502.1 - 0.025 14.8 8.4 0.2 11.8 8.6 1.9 1 1 0 1 1 1 0 EamA-like transporter family DUF3021 PF11457.8 EFA80502.1 - 0.041 14.2 4.7 0.075 13.4 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF1404 PF07185.11 EFA80502.1 - 0.052 13.3 2.7 0.072 12.8 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1404) DUF3290 PF11694.8 EFA80502.1 - 0.06 13.3 0.7 0.078 13.0 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) DUF5453 PF17534.2 EFA80502.1 - 0.15 12.0 5.3 0.2 11.6 4.8 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5453) EbsA PF17255.2 EFA80502.1 - 1.4 9.3 5.7 0.99 9.8 3.7 1.7 1 1 0 1 1 1 0 EbsA-like protein SUIM_assoc PF16619.5 EFA80503.1 - 0.017 15.2 0.6 0.017 15.2 0.6 7.2 4 4 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 zf-TRAF PF02176.18 EFA80504.1 - 5.4e-11 43.0 24.5 2.9e-10 40.7 6.3 4.2 2 2 3 5 5 5 2 TRAF-type zinc finger MATH PF00917.26 EFA80504.1 - 9.1e-07 29.0 0.1 9.1e-07 29.0 0.1 2.5 3 0 0 3 3 3 1 MATH domain zf-C3HC4_2 PF13923.6 EFA80504.1 - 5e-06 26.3 11.0 5e-06 26.3 11.0 3.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA80504.1 - 0.00021 21.6 9.2 0.00021 21.6 9.2 4.0 4 1 0 4 4 4 1 Ring finger domain zf-TRAF_2 PF15965.5 EFA80504.1 - 0.00026 21.4 9.3 0.00026 21.4 9.3 3.2 1 1 2 3 3 3 2 TRAF-like zinc-finger zf-RING_UBOX PF13445.6 EFA80504.1 - 0.00037 20.5 7.4 0.00037 20.5 7.4 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFA80504.1 - 0.002 18.2 10.0 0.002 18.2 10.0 2.6 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING Sina PF03145.16 EFA80504.1 - 0.007 16.3 25.5 0.12 12.4 3.0 3.9 1 1 2 3 3 3 2 Seven in absentia protein family HD_2 PF12917.7 EFA80504.1 - 0.02 14.6 1.0 0.36 10.6 0.0 2.2 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme PKcGMP_CC PF16808.5 EFA80504.1 - 0.12 12.2 5.0 0.33 10.8 1.7 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase fn3 PF00041.21 EFA80505.1 - 2.6e-22 79.0 13.2 0.0045 17.3 0.2 8.6 8 1 0 8 8 8 6 Fibronectin type III domain DUF2369 PF10179.9 EFA80505.1 - 0.00033 21.0 19.2 0.24 11.8 0.1 6.7 7 1 1 8 8 8 3 Uncharacterised conserved protein (DUF2369) EGF_2 PF07974.13 EFA80505.1 - 0.0013 19.1 15.6 0.0038 17.6 15.6 1.9 1 0 0 1 1 1 1 EGF-like domain Pur_ac_phosph_N PF16656.5 EFA80505.1 - 0.0044 17.6 26.2 12 6.5 0.5 9.1 7 2 0 7 7 7 2 Purple acid Phosphatase, N-terminal domain DUF1453 PF07301.11 EFA80505.1 - 0.092 12.7 0.0 0.32 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1453) DUF3042 PF11240.8 EFA80505.1 - 0.26 11.3 0.2 0.48 10.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Interfer-bind PF09294.10 EFA80505.1 - 0.71 10.2 9.3 3 8.2 0.1 5.0 4 1 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III DUF4286 PF14114.6 EFA80506.1 - 7.1e-22 77.7 0.2 8.5e-22 77.5 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4286) CLPTM1 PF05602.12 EFA80506.1 - 0.0093 15.0 0.5 0.01 14.9 0.5 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) MHB PF16525.5 EFA80506.1 - 0.13 12.6 0.1 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 Haemophore, haem-binding Alpha_L_fucos PF01120.17 EFA80507.1 - 9.5e-123 410.1 7.8 1.2e-122 409.8 7.8 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EFA80507.1 - 1.4e-16 60.8 0.1 4.2e-16 59.3 0.1 1.9 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Adaptin_N PF01602.20 EFA80508.1 - 2.4e-70 237.6 10.8 3.7e-70 237.0 10.8 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFA80508.1 - 2e-26 93.0 0.6 2.5e-23 82.9 0.0 3.4 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EFA80508.1 - 3.8e-19 68.8 0.1 9.9e-19 67.5 0.1 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 EFA80508.1 - 1.1e-05 25.2 0.0 5.2 7.6 0.0 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EFA80508.1 - 0.0017 18.7 0.0 0.049 14.0 0.0 3.0 2 2 1 3 3 3 2 HEAT repeats rve_2 PF13333.6 EFA80508.1 - 0.062 13.5 2.2 3.3 8.0 1.5 3.1 2 0 0 2 2 2 0 Integrase core domain zinc_ribbon_4 PF13717.6 EFA80509.1 - 0.55 10.2 4.0 15 5.6 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Mucin PF01456.17 EFA80509.1 - 0.61 10.1 40.6 3.1 7.8 14.5 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein zinc_ribbon_5 PF13719.6 EFA80509.1 - 0.97 9.2 5.4 5.4 6.9 1.5 2.5 2 0 0 2 2 2 0 zinc-ribbon domain PhoLip_ATPase_C PF16212.5 EFA80510.1 - 1.4e-65 221.5 28.6 1.4e-65 221.5 28.6 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA80510.1 - 2.8e-22 78.2 1.6 8.6e-22 76.6 1.6 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFA80510.1 - 4.1e-12 46.0 0.0 6.5e-11 42.2 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA80510.1 - 1.1e-09 38.9 0.0 0.00029 21.2 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFA80510.1 - 6.8e-07 29.0 0.0 6.8e-07 29.0 0.0 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFA80510.1 - 0.058 13.1 7.3 0.029 14.1 1.5 3.0 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Methyltransf_11 PF08241.12 EFA80511.1 - 4.6e-14 52.8 0.0 7.3e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA80511.1 - 9e-13 48.3 0.0 1.2e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA80511.1 - 4.9e-11 43.2 0.1 1.3e-10 41.8 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA80511.1 - 5.7e-06 27.0 0.0 1e-05 26.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA80511.1 - 0.00042 19.7 1.5 0.0031 16.9 1.5 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family TPMT PF05724.11 EFA80511.1 - 0.0057 16.3 0.0 0.0073 16.0 0.0 1.3 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 EFA80511.1 - 0.018 14.7 0.0 0.045 13.4 0.0 1.6 1 1 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 EFA80511.1 - 0.019 14.5 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EFA80511.1 - 0.026 14.5 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain LBP_M PF17385.2 EFA80511.1 - 0.049 13.1 0.1 0.068 12.7 0.1 1.2 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain Diphthami_syn_2 PF01902.17 EFA80512.1 - 1e-27 97.1 0.0 1.3e-27 96.8 0.0 1.0 1 0 0 1 1 1 1 Diphthamide synthase GST_N_2 PF13409.6 EFA80513.1 - 3.4e-22 78.5 0.1 1.1e-21 76.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA80513.1 - 6.7e-13 48.5 0.0 8e-12 45.0 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA80513.1 - 5.2e-10 39.4 0.0 8.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA80513.1 - 8.6e-05 22.7 0.0 0.00023 21.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA80513.1 - 0.00052 20.4 0.0 0.011 16.1 0.0 2.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFA80513.1 - 0.02 14.7 0.0 0.056 13.3 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RhoGAP PF00620.27 EFA80514.1 - 6.9e-22 77.9 2.5 8e-22 77.7 0.0 2.3 3 0 0 3 3 3 1 RhoGAP domain Afi1 PF07792.12 EFA80514.1 - 0.57 10.7 14.4 0.8 10.2 5.1 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM76 PF16046.5 EFA80514.1 - 1.3 8.4 12.4 0.15 11.4 1.6 2.1 2 0 0 2 2 2 0 FAM76 protein DUF3458 PF11940.8 EFA80514.1 - 1.7 9.1 10.1 0.9 10.0 4.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3458) Ig-like fold MRP-L46 PF11788.8 EFA80514.1 - 4.3 8.1 16.0 4.3 8.1 3.9 2.3 2 0 0 2 2 2 0 39S mitochondrial ribosomal protein L46 YL1 PF05764.13 EFA80515.1 - 5.6e-28 98.7 70.4 3.3e-20 73.3 36.6 3.1 2 1 1 3 3 3 3 YL1 nuclear protein YL1_C PF08265.11 EFA80515.1 - 2.1e-12 46.6 0.8 4.4e-12 45.5 0.2 1.9 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Sen15 PF09631.10 EFA80515.1 - 0.049 13.9 1.2 0.2 12.0 1.2 2.0 1 0 0 1 1 1 0 Sen15 protein Sec6 PF06046.13 EFA80516.1 - 5.5e-117 391.5 10.7 5.5e-117 391.5 10.7 1.6 2 0 0 2 2 2 1 Exocyst complex component Sec6 DEAD PF00270.29 EFA80516.1 - 1.4e-46 158.4 0.3 3.9e-45 153.8 0.0 3.1 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA80516.1 - 1.3e-24 86.6 0.6 1.3e-24 86.6 0.6 3.7 5 0 0 5 5 5 1 Helicase conserved C-terminal domain DUF948 PF06103.11 EFA80516.1 - 0.17 12.1 1.5 6.3 7.1 0.0 4.0 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) OSCP PF00213.18 EFA80516.1 - 1.4 9.0 5.8 0.5 10.5 0.9 2.8 3 0 0 3 3 3 0 ATP synthase delta (OSCP) subunit Pga1 PF10333.9 EFA80517.1 - 0.0026 17.6 4.0 0.075 12.9 4.0 2.2 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Exo_endo_phos PF03372.23 EFA80518.1 - 1.4e-13 50.9 0.0 2.2e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF910 PF06014.11 EFA80518.1 - 0.091 12.8 0.0 0.4 10.7 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF910) Cytadhesin_P30 PF07271.11 EFA80519.1 - 1.1 8.8 6.5 1.9 8.0 6.5 1.3 1 0 0 1 1 1 0 Cytadhesin P30/P32 FMN_red PF03358.15 EFA80520.1 - 9e-28 97.0 0.0 1.4e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFA80520.1 - 4.3e-08 33.1 0.0 5.8e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold TMF_DNA_bd PF12329.8 EFA80521.1 - 0.0048 16.9 14.2 0.0048 16.9 14.2 6.4 6 1 1 7 7 7 1 TATA element modulatory factor 1 DNA binding Coilin_N PF15862.5 EFA80521.1 - 0.016 15.0 0.0 0.016 15.0 0.0 5.9 3 2 2 5 5 5 0 Coilin N-terminus Glyco_transf_28 PF03033.20 EFA80522.1 - 3.3e-11 43.4 0.0 1.2e-10 41.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EFA80522.1 - 3.3e-09 36.1 0.0 1.4e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFA80522.1 - 0.00026 21.0 0.0 0.00047 20.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.6 EFA80522.1 - 0.18 11.8 0.0 2 8.4 0.0 2.3 2 1 0 2 2 2 0 Glycosyltransferase Family 4 RhoGEF PF00621.20 EFA80523.1 - 6.2e-46 156.9 4.3 6.2e-46 156.9 4.3 1.9 2 0 0 2 2 2 1 RhoGEF domain DZR PF12773.7 EFA80523.1 - 0.021 14.8 6.2 0.061 13.3 6.2 1.8 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EFA80523.1 - 0.27 11.0 5.3 0.23 11.2 2.6 2.4 1 1 1 2 2 2 0 zinc-ribbon domain Metallophos PF00149.28 EFA80524.1 - 2.2e-18 67.5 0.4 5.9e-18 66.1 0.1 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFA80524.1 - 1.8e-14 54.1 7.9 1.8e-13 50.9 7.9 2.2 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFA80524.1 - 1.3e-08 35.5 0.1 5.5e-08 33.6 0.0 2.2 2 0 0 2 2 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 EFA80524.1 - 1.4e-06 28.6 0.0 4.9e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain BUD22 PF09073.10 EFA80524.1 - 0.002 17.5 5.3 0.0028 17.1 5.3 1.1 1 0 0 1 1 1 1 BUD22 Apt1 PF10351.9 EFA80524.1 - 0.0041 16.0 0.3 0.0053 15.7 0.3 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Velvet PF11754.8 EFA80524.1 - 0.016 15.1 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 Velvet factor ThrE PF06738.12 EFA80524.1 - 0.032 13.6 0.1 4.3 6.6 0.1 2.2 2 0 0 2 2 2 0 Putative threonine/serine exporter Parvo_NS1 PF01057.17 EFA80524.1 - 0.034 13.2 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CCDC106 PF15794.5 EFA80524.1 - 0.04 13.6 4.8 0.064 13.0 4.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Macoilin PF09726.9 EFA80524.1 - 0.21 10.1 3.0 0.28 9.7 3.0 1.1 1 0 0 1 1 1 0 Macoilin family EFTUD2 PF16004.5 EFA80524.1 - 0.68 10.5 2.9 1 9.9 2.3 1.6 2 0 0 2 2 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus SR-25 PF10500.9 EFA80524.1 - 0.69 9.5 19.7 1 8.9 19.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4614 PF15391.6 EFA80524.1 - 1.6 8.7 9.6 3 7.8 9.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Rho_N PF07498.12 EFA80525.1 - 0.55 10.2 5.4 0.4 10.6 2.4 2.3 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain SAM_Exu PF18609.1 EFA80525.1 - 1.8 8.7 4.0 1.3 9.2 0.4 2.6 3 0 0 3 3 3 0 Exuperantia SAM-like domain CCDC53 PF10152.9 EFA80526.1 - 0.0012 19.3 0.9 0.0014 19.1 0.9 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Allexi_40kDa PF05549.11 EFA80526.1 - 0.0086 15.6 0.2 0.009 15.6 0.2 1.0 1 0 0 1 1 1 1 Allexivirus 40kDa protein NPV_P10 PF05531.12 EFA80526.1 - 0.049 14.1 0.4 0.22 12.0 0.0 1.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein P2X_receptor PF00864.19 EFA80527.1 - 1.1e-21 77.4 1.3 8.5e-10 38.2 0.0 2.8 2 1 1 3 3 3 3 ATP P2X receptor GTP_EFTU PF00009.27 EFA80528.1 - 2.2e-46 157.8 0.0 4.4e-46 156.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFA80528.1 - 1.6e-26 92.8 0.0 4e-26 91.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFA80528.1 - 8.7e-06 25.8 0.0 0.0055 16.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFA80528.1 - 2.3e-05 24.7 0.1 6.4e-05 23.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFA80528.1 - 0.0022 17.8 0.1 0.0057 16.5 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 HTH_33 PF13592.6 EFA80528.1 - 0.027 14.1 0.6 0.18 11.5 0.4 2.2 2 0 0 2 2 2 0 Winged helix-turn helix Ras PF00071.22 EFA80528.1 - 0.041 13.5 0.2 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 Ras family Actin PF00022.19 EFA80529.1 - 9.4e-88 294.5 0.0 4.7e-85 285.7 0.0 2.0 1 1 0 1 1 1 1 Actin PH_3 PF14593.6 EFA80529.1 - 0.059 13.5 0.3 9.3 6.4 0.1 2.3 2 0 0 2 2 2 0 PH domain Senescence PF06911.12 EFA80530.1 - 1.1e-27 97.6 7.8 1.1e-27 97.6 7.8 1.7 1 1 0 1 1 1 1 Senescence-associated protein PPR_2 PF13041.6 EFA80531.1 - 3.2e-11 43.2 8.8 0.48 10.7 0.0 8.7 9 0 0 9 9 9 4 PPR repeat family PPR_long PF17177.4 EFA80531.1 - 5.7e-07 29.1 0.9 2.8e-06 26.8 0.0 2.6 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EFA80531.1 - 3.2e-06 27.0 7.2 1.1 9.7 0.1 8.1 9 0 0 9 9 9 2 PPR repeat PPR_3 PF13812.6 EFA80531.1 - 3e-05 24.0 6.6 1.9 8.6 0.0 5.5 4 1 2 6 6 6 2 Pentatricopeptide repeat domain ERCC4 PF02732.15 EFA80532.1 - 7.3e-17 62.0 0.1 7.3e-17 62.0 0.1 3.1 3 0 0 3 3 3 1 ERCC4 domain PDDEXK_5 PF11645.8 EFA80532.1 - 0.047 13.7 5.4 2.9 7.9 2.0 2.9 1 1 1 2 2 2 0 PD-(D/E)XK endonuclease COQ7 PF03232.13 EFA80532.1 - 0.12 12.1 0.1 0.58 9.9 0.0 2.0 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 DUF4441 PF14536.6 EFA80532.1 - 0.13 12.4 18.3 4.7 7.4 3.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4441) ABC2_membrane_3 PF12698.7 EFA80532.1 - 5 6.1 5.5 14 4.7 5.5 1.8 1 0 0 1 1 1 0 ABC-2 family transporter protein ubiquitin PF00240.23 EFA80533.1 - 0.00045 19.9 0.1 0.0012 18.5 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA80533.1 - 0.027 14.3 0.2 0.086 12.7 0.2 1.9 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Imm26 PF15428.6 EFA80534.1 - 0.033 14.4 0.0 0.039 14.2 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 26 Arteri_Gl PF00951.18 EFA80535.1 - 0.0069 16.2 1.8 0.013 15.3 1.8 1.4 1 0 0 1 1 1 1 Arterivirus GL envelope glycoprotein DUF3849 PF12960.7 EFA80535.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) Wzy_C PF04932.15 EFA80535.1 - 0.37 10.4 8.6 6.8 6.3 7.0 2.9 2 1 0 2 2 2 0 O-Antigen ligase Cys_Met_Meta_PP PF01053.20 EFA80536.1 - 0.053 12.0 0.1 0.082 11.4 0.1 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Edc3_linker PF16598.5 EFA80537.1 - 2.9 8.6 8.3 3 8.6 6.3 2.0 1 1 1 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 EF-hand_6 PF13405.6 EFA80538.1 - 0.094 12.7 0.0 0.39 10.8 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain eIF3m_C_helix PF18005.1 EFA80538.1 - 0.21 11.3 2.5 0.54 10.0 2.5 1.7 1 0 0 1 1 1 0 eIF3 subunit M, C-terminal helix PDDEXK_1 PF12705.7 EFA80539.1 - 5.8e-05 23.1 0.3 0.00014 21.8 0.3 1.9 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.17 EFA80539.1 - 0.0052 16.9 0.4 0.011 15.9 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF83 Sorting_nexin PF03700.13 EFA80539.1 - 0.32 11.5 8.8 0.59 10.7 8.8 1.4 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain RIFIN PF02009.16 EFA80539.1 - 1.5 8.7 6.2 2.6 7.9 6.2 1.3 1 0 0 1 1 1 0 Rifin Spc24 PF08286.11 EFA80540.1 - 0.061 13.6 14.6 0.082 13.2 1.9 3.2 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 PH_4 PF15404.6 EFA80540.1 - 0.09 12.6 4.1 0.097 12.5 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DUF2722 PF10846.8 EFA80540.1 - 0.12 11.3 14.1 0.81 8.6 6.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 EFA80540.1 - 0.15 12.0 13.3 1.4 8.8 1.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 EFA80540.1 - 0.16 12.0 0.8 0.33 11.0 0.8 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MCM6_C PF18263.1 EFA80540.1 - 0.22 11.7 0.1 0.22 11.7 0.1 3.1 2 1 1 3 3 3 0 MCM6 C-terminal winged-helix domain PARP_reg PF02877.14 EFA80540.1 - 0.28 11.3 5.7 0.75 9.9 0.0 2.9 3 0 0 3 3 3 0 Poly(ADP-ribose) polymerase, regulatory domain ANAPC_CDC26 PF10471.9 EFA80540.1 - 0.86 10.5 20.9 1.1 10.2 3.1 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Med15 PF09606.10 EFA80540.1 - 1.1 7.9 14.3 0.84 8.2 0.7 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2203 PF09969.9 EFA80540.1 - 2.6 8.8 5.5 7.9 7.2 0.8 2.7 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2203) Ly49 PF08391.10 EFA80540.1 - 4.9 7.5 12.1 3.6 8.0 2.8 2.5 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region SUIM_assoc PF16619.5 EFA80540.1 - 5.9 7.0 23.5 0.87 9.7 0.2 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 GrpE PF01025.19 EFA80540.1 - 8.2 6.1 12.5 1.4 8.6 5.8 2.4 2 0 0 2 2 2 0 GrpE MFAP1 PF06991.11 EFA80541.1 - 5.3e-58 196.4 30.9 5.3e-58 196.4 30.9 3.2 1 1 2 3 3 3 1 Microfibril-associated/Pre-mRNA processing BAR PF03114.18 EFA80542.1 - 0.0005 19.8 10.2 0.0029 17.3 10.2 1.9 1 1 0 1 1 1 1 BAR domain GBP_C PF02841.14 EFA80542.1 - 0.028 13.8 5.1 0.058 12.8 5.1 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FapA PF03961.13 EFA80542.1 - 0.67 8.5 4.3 1 7.9 4.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Sec8_exocyst PF04048.14 EFA80542.1 - 2.4 8.1 10.1 12 5.8 0.2 2.9 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Coatomer_WDAD PF04053.14 EFA80543.1 - 1.3e-161 538.6 1.8 2.7e-161 537.6 0.1 2.0 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EFA80543.1 - 4.8e-43 144.3 3.2 4.5e-08 33.6 0.1 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80543.1 - 1.2e-06 28.7 1.5 3.7 7.9 0.0 6.3 5 2 3 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA80543.1 - 0.024 13.3 1.0 2.9 6.4 0.1 3.4 1 1 0 2 2 2 0 Nucleoporin Nup120/160 ABC2_membrane PF01061.24 EFA80546.1 - 5.1e-41 140.4 22.9 8.2e-41 139.7 22.9 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFA80546.1 - 1.2e-24 87.4 0.0 1.9e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA80546.1 - 2e-09 37.7 1.6 2.3e-05 24.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA80546.1 - 0.00025 20.5 0.1 0.018 14.5 0.1 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EFA80546.1 - 0.0023 17.1 16.5 0.0048 16.1 16.5 1.6 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 EFA80546.1 - 0.011 15.1 3.7 0.023 14.0 3.7 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFA80546.1 - 0.021 14.7 0.1 0.043 13.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 EFA80546.1 - 0.036 14.3 0.0 0.16 12.2 0.0 2.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFA80546.1 - 0.082 12.7 0.4 0.18 11.6 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA80546.1 - 0.13 12.6 0.1 0.3 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFA80546.1 - 0.22 12.1 0.1 0.59 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 EFA80547.1 - 3e-24 85.8 0.0 4.8e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80547.1 - 2e-13 50.2 0.0 2.8e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA80547.1 - 9e-10 37.9 0.1 9e-10 37.9 0.1 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFA80547.1 - 0.0098 15.8 0.0 0.026 14.5 0.1 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA80547.1 - 0.11 11.8 1.5 0.14 11.5 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Menin PF05053.13 EFA80547.1 - 1.9 6.8 7.4 2.6 6.3 7.4 1.1 1 0 0 1 1 1 0 Menin p450 PF00067.22 EFA80548.1 - 7e-96 321.8 0.0 7e-96 321.8 0.0 2.0 2 0 0 2 2 2 1 Cytochrome P450 MSC PF09402.10 EFA80550.1 - 2.7e-20 73.1 1.5 2.7e-20 73.1 1.5 3.5 2 1 0 3 3 3 1 Man1-Src1p-C-terminal domain Pex14_N PF04695.13 EFA80550.1 - 0.021 15.5 8.2 0.021 15.5 8.2 5.3 3 2 1 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4250 PF14056.6 EFA80550.1 - 0.043 13.8 0.0 0.15 12.1 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF4064 PF13273.6 EFA80550.1 - 0.065 13.5 0.1 0.24 11.7 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) ABC2_membrane_3 PF12698.7 EFA80550.1 - 0.36 9.9 14.4 0.022 13.9 2.8 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein 60KD_IMP PF02096.20 EFA80550.1 - 5.3 6.9 12.7 2.7 7.8 8.8 2.2 2 0 0 2 2 2 0 60Kd inner membrane protein Rpr2 PF04032.16 EFA80551.1 - 2.9e-18 66.0 5.3 2.9e-18 66.0 5.3 2.4 1 1 1 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zinc_ribbon_12 PF11331.8 EFA80551.1 - 0.25 11.2 2.1 0.7 9.7 2.1 1.8 1 1 0 1 1 1 0 Probable zinc-ribbon domain DUF4519 PF15012.6 EFA80551.1 - 1.3 9.2 4.6 2.9 8.1 4.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) FUR PF01475.19 EFA80551.1 - 1.5 9.0 8.2 0.3 11.2 3.1 2.3 1 1 1 3 3 3 0 Ferric uptake regulator family Methyltransf_11 PF08241.12 EFA80552.1 - 1.2e-16 61.1 0.0 2.1e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA80552.1 - 4.9e-15 56.0 0.0 3e-14 53.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA80552.1 - 8.8e-09 35.0 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFA80552.1 - 4.6e-07 29.7 0.0 1.1e-06 28.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA80552.1 - 8.4e-07 29.7 0.0 2.1e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA80552.1 - 0.00018 21.4 0.0 0.00022 21.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 EFA80552.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) RrnaAD PF00398.20 EFA80552.1 - 0.012 14.7 0.1 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 EFA80552.1 - 0.029 14.5 0.0 0.056 13.6 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase HEAT PF02985.22 EFA80552.1 - 0.043 14.1 0.1 17 6.0 0.1 2.5 2 0 0 2 2 2 0 HEAT repeat DREV PF05219.12 EFA80552.1 - 0.059 12.4 0.0 0.29 10.2 0.0 1.9 2 0 0 2 2 2 0 DREV methyltransferase PCMT PF01135.19 EFA80552.1 - 0.067 12.9 0.0 0.14 11.9 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 EFA80552.1 - 0.07 12.7 0.0 0.26 10.8 0.0 1.8 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW FNIP PF05725.12 EFA80553.1 - 7.8e-32 109.2 33.2 1.7e-14 53.7 0.7 7.7 5 2 0 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA80553.1 - 0.00014 21.4 0.1 0.00033 20.2 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80553.1 - 0.00059 19.7 0.0 0.0016 18.3 0.0 1.8 1 0 0 1 1 1 1 F-box-like Sporozoite_P67 PF05642.11 EFA80553.1 - 0.13 10.3 1.1 0.2 9.7 1.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TIG PF01833.24 EFA80554.1 - 0.00057 19.9 10.8 0.002 18.2 2.8 3.8 2 1 0 2 2 2 1 IPT/TIG domain EGF_2 PF07974.13 EFA80554.1 - 0.0082 16.5 15.5 0.018 15.4 15.5 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EFA80554.1 - 0.36 11.5 9.0 1.3 9.8 9.0 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF LRR_4 PF12799.7 EFA80554.1 - 3.3 8.2 0.0 3.3 8.2 0.0 5.0 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) H_lectin PF09458.10 EFA80555.1 - 3e-14 53.0 2.0 6.9e-14 51.8 2.0 1.7 1 0 0 1 1 1 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA80555.1 - 2.6e-06 27.6 0.5 6.2e-06 26.3 0.5 1.7 1 1 0 1 1 1 1 F5/8 type C domain NDT80_PhoG PF05224.12 EFA80558.1 - 3.9e-30 105.4 2.6 1.9e-28 99.9 0.0 3.4 2 1 0 2 2 2 1 NDT80 / PhoG like DNA-binding family Peptidase_S74 PF13884.6 EFA80558.1 - 1.6e-09 37.9 0.1 3.1e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Chaperone of endosialidase MRF_C1 PF13887.6 EFA80558.1 - 0.0036 16.4 0.0 0.0063 15.7 0.0 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Nucleoporin_FG PF13634.6 EFA80559.1 - 6.8e-05 23.6 45.2 0.00056 20.7 24.0 20.7 6 4 14 20 20 20 8 Nucleoporin FG repeat region Ribosomal_60s PF00428.19 EFA80560.1 - 4.1e-25 88.2 10.9 4.8e-25 88.0 10.9 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 EFA80560.1 - 0.11 13.0 1.7 6.6 7.2 0.5 2.0 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Shadoo PF14999.6 EFA80560.1 - 0.25 11.5 5.6 0.35 10.9 5.6 1.2 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF3824 PF12868.7 EFA80560.1 - 0.86 10.3 7.4 1.3 9.7 7.4 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) 2OG-FeII_Oxy_3 PF13640.6 EFA80561.1 - 1.1e-11 45.4 0.2 2.8e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EFA80561.1 - 0.00084 19.7 0.0 0.0019 18.6 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase PhyH PF05721.13 EFA80561.1 - 0.02 15.2 0.0 0.42 10.8 0.0 2.3 1 1 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Pneumovirus_M2 PF06436.11 EFA80562.1 - 0.33 10.4 4.3 24 4.4 0.1 3.4 3 0 0 3 3 3 0 Pneumovirus matrix protein 2 (M2) Ank_2 PF12796.7 EFA80563.1 - 4.1e-13 49.7 4.0 6e-06 26.8 0.1 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80563.1 - 3.5e-12 46.3 0.6 0.043 14.2 0.0 4.9 2 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80563.1 - 1.4e-09 38.2 4.5 0.0026 18.3 0.2 4.6 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80563.1 - 2e-06 27.7 2.2 2.4 9.0 0.0 5.1 5 1 1 6 6 6 2 Ankyrin repeat CLTH PF10607.9 EFA80563.1 - 0.0087 16.0 0.7 0.19 11.6 0.7 2.3 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Bin3 PF06859.12 EFA80563.1 - 0.083 13.5 3.0 7.5 7.2 0.1 3.0 3 0 0 3 3 3 0 Bicoid-interacting protein 3 (Bin3) FNIP PF05725.12 EFA80564.1 - 3.6e-17 62.2 56.5 1.1e-07 31.9 0.9 9.7 6 2 3 9 9 9 4 FNIP Repeat F-box_5 PF18511.1 EFA80564.1 - 3.6e-06 26.4 0.3 7.3e-06 25.5 0.3 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80564.1 - 0.0017 18.2 0.1 0.0067 16.3 0.1 2.1 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFA80564.1 - 3.5 8.2 20.4 0.59 10.6 3.1 6.3 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 EFA80565.1 - 2.5e-24 85.1 44.7 4.1e-09 36.4 1.1 9.1 7 2 2 9 9 9 6 FNIP Repeat F-box_5 PF18511.1 EFA80565.1 - 3.6e-05 23.2 0.2 7.8e-05 22.2 0.2 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80565.1 - 0.027 14.4 0.2 0.11 12.4 0.2 2.1 1 0 0 1 1 1 0 F-box-like FNIP PF05725.12 EFA80566.1 - 1.7e-29 101.7 34.2 1.4e-12 47.5 0.3 11.0 10 2 1 11 11 11 7 FNIP Repeat F-box_5 PF18511.1 EFA80566.1 - 0.0018 17.8 0.2 0.0043 16.6 0.2 1.6 1 0 0 1 1 1 1 F-box DUF1769 PF08588.10 EFA80566.1 - 0.025 14.8 2.1 0.96 9.7 0.0 3.7 5 0 0 5 5 5 0 Protein of unknown function (DUF1769) DUF2634 PF10934.8 EFA80567.1 - 0.0013 18.8 0.9 0.0017 18.4 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2634) F-box_5 PF18511.1 EFA80567.1 - 0.0038 16.8 0.0 0.0062 16.1 0.0 1.3 1 0 0 1 1 1 1 F-box PhoQ_Sensor PF08918.10 EFA80567.1 - 0.0098 15.8 1.4 0.012 15.5 1.4 1.0 1 0 0 1 1 1 1 PhoQ Sensor HSP70 PF00012.20 EFA80568.1 - 1e-109 367.5 0.8 1.5e-109 366.9 0.8 1.1 1 0 0 1 1 1 1 Hsp70 protein AMP-binding PF00501.28 EFA80568.1 - 1.9e-37 128.9 0.0 6.4e-37 127.2 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme MreB_Mbl PF06723.13 EFA80568.1 - 7.3e-13 48.0 0.1 1.2e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 MreB/Mbl protein HyaE PF07449.11 EFA80568.1 - 0.013 15.4 0.0 0.039 13.9 0.0 1.8 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE PilM_2 PF11104.8 EFA80568.1 - 0.035 13.1 0.5 0.6 9.1 0.1 2.2 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; DUF1464 PF07318.12 EFA80568.1 - 0.042 13.0 0.0 0.081 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) ZZ PF00569.17 EFA80568.1 - 0.051 13.4 1.4 0.13 12.1 1.4 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF2314 PF10077.9 EFA80568.1 - 0.051 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2314) CT_C_D PF02682.16 EFA80568.1 - 0.11 12.2 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D Ank_2 PF12796.7 EFA80569.1 - 5.4e-15 55.7 3.8 6.7e-05 23.4 0.0 5.8 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80569.1 - 2.2e-12 47.0 1.6 0.16 12.3 0.1 7.5 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80569.1 - 1.9e-10 41.0 4.3 0.0014 19.2 0.1 6.8 7 1 0 7 7 7 2 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA80569.1 - 5.5e-05 23.0 5.3 0.17 11.6 0.4 4.3 3 1 1 4 4 4 3 Multigene family 530 protein Ank_3 PF13606.6 EFA80569.1 - 7.8e-05 22.8 0.1 63 4.6 0.0 6.8 6 0 0 6 6 6 0 Ankyrin repeat FNIP PF05725.12 EFA80570.1 - 5.2e-13 48.9 23.5 9.1e-08 32.1 2.4 7.9 4 2 3 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA80570.1 - 0.00021 20.8 0.0 0.00046 19.7 0.0 1.5 1 0 0 1 1 1 1 F-box Methyltransf_31 PF13847.6 EFA80571.1 - 1.1e-16 61.0 0.2 1.5e-16 60.6 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA80571.1 - 1.2e-12 48.4 0.0 2.1e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA80571.1 - 2.7e-11 44.0 0.0 5.1e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA80571.1 - 1.3e-09 38.6 0.4 2.6e-09 37.7 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 EFA80571.1 - 5.1e-09 35.9 0.0 7.4e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EFA80571.1 - 2.8e-08 33.4 0.5 3.8e-08 33.0 0.5 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_23 PF13489.6 EFA80571.1 - 6.4e-07 29.4 0.0 1.5e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA80571.1 - 0.00018 21.0 0.8 0.00024 20.6 0.4 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EFA80571.1 - 0.00041 19.7 0.1 0.00055 19.3 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Pox_MCEL PF03291.16 EFA80571.1 - 0.0049 16.0 2.2 0.12 11.4 2.2 2.1 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_32 PF13679.6 EFA80571.1 - 0.0083 16.1 0.5 0.018 15.0 0.2 1.7 2 1 0 2 2 2 1 Methyltransferase domain LpoB PF13036.6 EFA80571.1 - 0.013 15.4 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Peptidoglycan-synthase activator LpoB Methyltransf_8 PF05148.15 EFA80571.1 - 0.014 15.3 0.1 0.19 11.5 0.1 2.1 1 1 1 2 2 2 0 Hypothetical methyltransferase DUF4213 PF13938.6 EFA80571.1 - 0.044 14.0 0.0 0.075 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative heavy-metal chelation Methyltransf_9 PF08003.11 EFA80571.1 - 0.054 12.4 0.0 0.071 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) YnfE PF17452.2 EFA80571.1 - 0.079 13.3 0.8 0.44 10.9 0.1 2.5 3 0 0 3 3 3 0 Uncharacterized YnfE-like PCMT PF01135.19 EFA80571.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 EFA80571.1 - 0.12 12.4 0.6 0.26 11.2 0.3 1.7 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 EFA80571.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FNIP PF05725.12 EFA80572.1 - 7.3e-10 38.9 1.1 1.1e-08 35.1 0.0 2.8 2 1 0 2 2 2 1 FNIP Repeat SEF14_adhesin PF06443.11 EFA80573.1 - 0.011 15.6 0.2 0.021 14.7 0.2 1.4 1 0 0 1 1 1 0 SEF14-like adhesin DUF1482 PF07358.11 EFA80576.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1482) FNIP PF05725.12 EFA80577.1 - 3.1e-20 72.1 49.8 2.9e-08 33.7 1.4 9.4 5 2 3 8 8 8 8 FNIP Repeat F-box_5 PF18511.1 EFA80577.1 - 4.5e-06 26.1 0.3 8.8e-06 25.2 0.3 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80577.1 - 0.0037 17.1 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 F-box-like Glyco_hydro_65C PF03633.15 EFA80577.1 - 0.079 12.9 0.4 1.3 9.0 0.0 3.0 3 0 0 3 3 3 0 Glycosyl hydrolase family 65, C-terminal domain FNIP PF05725.12 EFA80578.1 - 9e-31 105.8 31.6 2e-15 56.6 5.8 6.8 7 0 0 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA80578.1 - 1.3e-05 24.6 0.1 2.5e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80578.1 - 0.02 14.8 0.1 0.095 12.6 0.1 2.2 1 0 0 1 1 1 0 F-box-like DUF3156 PF11354.8 EFA80578.1 - 0.11 12.4 0.1 0.64 9.9 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3156) FGGY_N PF00370.21 EFA80579.1 - 6e-23 81.7 2.2 1.7e-18 67.1 0.4 2.2 1 1 1 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EFA80579.1 - 4.9e-06 26.4 0.1 3.8e-05 23.5 0.0 1.9 1 1 1 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EFA80579.1 - 0.041 13.4 0.2 0.081 12.4 0.0 1.6 1 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family RsgA_GTPase PF03193.16 EFA80580.1 - 2.1e-06 27.8 1.2 8.3e-05 22.5 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 EFA80580.1 - 2.3e-05 24.5 0.0 4.8e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFA80580.1 - 0.00019 22.0 0.2 0.00043 20.8 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 EFA80580.1 - 0.00045 19.6 0.1 0.00077 18.8 0.1 1.6 1 1 0 1 1 1 1 AIG1 family Septin PF00735.18 EFA80580.1 - 0.0016 17.8 0.0 0.0049 16.2 0.0 1.8 1 1 0 1 1 1 1 Septin AAA_29 PF13555.6 EFA80580.1 - 0.0051 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Cluap1 PF10234.9 EFA80580.1 - 0.09 12.2 4.0 0.13 11.6 4.0 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 AIG1 PF04548.16 EFA80581.1 - 2.2e-17 63.1 0.8 3.8e-17 62.3 0.2 1.6 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFA80581.1 - 0.011 15.6 1.0 0.019 14.9 0.2 1.8 2 0 0 2 2 2 0 RsgA GTPase Mucin PF01456.17 EFA80583.1 - 0.041 13.9 25.0 0.07 13.1 25.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein HSDR_N_2 PF13588.6 EFA80583.1 - 0.16 11.9 0.9 1.9 8.5 0.3 2.2 1 1 1 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) MGC-24 PF05283.11 EFA80583.1 - 0.28 11.6 14.6 0.6 10.6 14.6 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 EFA80583.1 - 0.49 8.5 10.6 0.67 8.0 10.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus AIG1 PF04548.16 EFA80584.1 - 3.5e-16 59.2 0.2 7.5e-16 58.1 0.2 1.5 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EFA80584.1 - 0.013 15.4 0.7 0.035 14.0 0.1 2.0 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EFA80584.1 - 0.032 14.3 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Thioredox_DsbH PF03190.15 EFA80584.1 - 0.1 12.6 0.5 0.31 11.0 0.3 2.1 2 1 0 2 2 2 0 Protein of unknown function, DUF255 DUF3156 PF11354.8 EFA80585.1 - 0.037 13.9 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3156) FNIP PF05725.12 EFA80585.1 - 0.089 13.0 0.1 6.5 7.0 0.0 2.9 3 0 0 3 3 3 0 FNIP Repeat FGGY_N PF00370.21 EFA80586.1 - 3.1e-83 279.1 0.0 4.1e-83 278.7 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EFA80586.1 - 1.9e-29 102.8 0.2 3e-29 102.2 0.2 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EFA80586.1 - 0.0027 17.3 0.4 0.089 12.3 0.2 2.9 3 1 0 4 4 4 1 BadF/BadG/BcrA/BcrD ATPase family Ntox34 PF15606.6 EFA80586.1 - 0.17 12.0 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 34 FNIP PF05725.12 EFA80587.1 - 1.1e-42 143.9 36.8 4.1e-15 55.7 3.7 5.9 3 1 4 7 7 7 6 FNIP Repeat F-box_5 PF18511.1 EFA80587.1 - 8.2e-06 25.3 0.3 1.9e-05 24.1 0.3 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80587.1 - 0.0044 16.9 0.2 0.011 15.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like Sigma70_ner PF04546.13 EFA80587.1 - 0.048 13.5 2.3 0.088 12.7 2.3 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 EFA80587.1 - 0.19 9.9 8.8 0.26 9.5 8.8 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 EFA80587.1 - 0.43 11.0 7.6 0.9 10.0 7.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFA80587.1 - 0.55 9.9 4.3 0.99 9.1 4.3 1.4 1 0 0 1 1 1 0 FAM176 family NAM-associated PF14303.6 EFA80587.1 - 1.1 10.0 9.7 0.027 15.2 3.0 1.7 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain PTPRCAP PF15713.5 EFA80587.1 - 4.7 7.5 10.4 8.1 6.7 10.4 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PBP1_TM PF14812.6 EFA80587.1 - 9.4 6.7 10.8 5.2 7.5 5.3 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MR_MLE_C PF13378.6 EFA80588.1 - 0.22 11.0 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Enolase C-terminal domain-like SMC_N PF02463.19 EFA80589.1 - 9.2e-69 231.2 38.5 5.8e-35 120.7 4.5 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFA80589.1 - 1.1e-26 93.5 1.3 3.7e-26 91.7 0.1 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFA80589.1 - 2.1e-11 44.2 6.1 3.9e-06 26.9 0.5 3.3 2 2 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA80589.1 - 3.3e-09 36.9 13.8 3.3e-09 36.9 13.8 5.6 3 2 2 5 5 2 1 AAA ATPase domain AAA_29 PF13555.6 EFA80589.1 - 6.4e-07 29.0 0.0 1.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.6 EFA80589.1 - 0.0047 16.3 22.4 0.0047 16.3 22.4 8.8 3 2 6 9 9 7 4 Growth-arrest specific micro-tubule binding DUF745 PF05335.13 EFA80589.1 - 0.0059 16.3 13.9 0.0059 16.3 13.9 5.9 5 2 1 6 6 5 1 Protein of unknown function (DUF745) FlaC_arch PF05377.11 EFA80589.1 - 0.011 16.2 0.7 0.011 16.2 0.7 11.3 8 3 4 13 13 11 0 Flagella accessory protein C (FlaC) ABC_tran PF00005.27 EFA80589.1 - 0.04 14.4 0.1 0.04 14.4 0.1 7.9 4 2 0 6 6 4 0 ABC transporter Dimerisation PF08100.11 EFA80589.1 - 0.071 13.1 0.2 0.25 11.4 0.2 2.0 1 0 0 1 1 1 0 Dimerisation domain Peripla_BP_4 PF13407.6 EFA80589.1 - 3.3 7.2 9.3 0.11 12.0 0.2 3.1 3 0 0 3 3 3 0 Periplasmic binding protein domain FNIP PF05725.12 EFA80590.1 - 3.5e-36 123.1 11.2 5.2e-14 52.1 1.6 7.0 4 1 2 7 7 7 6 FNIP Repeat EST1 PF10374.9 EFA80591.1 - 0.45 11.2 4.3 3.4 8.3 4.3 2.1 1 1 0 1 1 1 0 Telomerase activating protein Est1 H_lectin PF09458.10 EFA80592.1 - 3e-14 53.0 2.0 6.9e-14 51.8 2.0 1.7 1 0 0 1 1 1 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA80592.1 - 2.6e-06 27.6 0.5 6.2e-06 26.3 0.5 1.7 1 1 0 1 1 1 1 F5/8 type C domain TIG PF01833.24 EFA80593.1 - 0.00023 21.1 11.3 0.0011 19.0 2.3 4.0 2 1 0 2 2 2 1 IPT/TIG domain EGF_2 PF07974.13 EFA80593.1 - 0.0071 16.7 15.5 0.018 15.4 15.5 1.7 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 EFA80593.1 - 0.34 11.1 6.5 1.1 9.5 6.5 1.8 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 EFA80593.1 - 0.42 11.3 9.0 1.3 9.8 9.0 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF ETRAMP PF09716.10 EFA80593.1 - 2.2 8.4 4.5 1.6 8.9 0.2 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FNIP PF05725.12 EFA80594.1 - 1.7e-36 124.1 24.6 8e-16 57.9 4.3 6.6 4 2 1 6 6 6 6 FNIP Repeat FNIP PF05725.12 EFA80596.1 - 8.6e-24 83.4 45.2 3.2e-12 46.4 0.5 9.4 8 1 0 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA80596.1 - 2.4e-05 23.8 0.5 2.4e-05 23.8 0.5 1.9 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 EFA80596.1 - 0.073 13.0 0.1 0.24 11.4 0.1 1.8 1 0 0 1 1 1 0 F-box-like JmjC PF02373.22 EFA80596.1 - 0.13 12.7 1.0 0.26 11.7 1.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase FNIP PF05725.12 EFA80597.1 - 4.5e-29 100.3 34.1 1.5e-08 34.7 0.1 9.8 6 3 3 10 10 10 8 FNIP Repeat F-box_5 PF18511.1 EFA80597.1 - 6e-05 22.5 0.3 0.00017 21.1 0.3 1.7 1 0 0 1 1 1 1 F-box TAP_C PF03943.13 EFA80599.1 - 1.8e-08 33.9 1.0 3.7e-08 32.9 1.0 1.5 1 0 0 1 1 1 1 TAP C-terminal domain UBA_4 PF14555.6 EFA80599.1 - 3.4e-07 30.0 0.2 7.6e-07 28.9 0.2 1.6 1 0 0 1 1 1 1 UBA-like domain NTF2 PF02136.20 EFA80599.1 - 3.7e-07 30.7 2.0 8.2e-07 29.6 0.1 2.3 2 1 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain LRR_9 PF14580.6 EFA80599.1 - 2.2e-06 27.3 0.6 0.00036 20.1 0.1 2.7 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 EFA80599.1 - 2.9e-05 24.4 9.3 0.0062 16.9 1.2 3.6 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) DUF4220 PF13968.6 EFA80599.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) LRR_4 PF12799.7 EFA80600.1 - 7.2e-23 80.3 24.7 0.0039 17.6 0.1 12.4 8 2 4 13 13 13 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFA80600.1 - 1.7e-19 68.1 23.6 1.7 8.9 0.0 16.4 17 0 0 17 17 17 6 Leucine Rich repeat ABC_tran PF00005.27 EFA80600.1 - 0.00076 20.0 2.1 0.019 15.5 0.0 2.9 2 0 0 2 2 2 1 ABC transporter LRR_1 PF00560.33 EFA80600.1 - 0.00079 19.6 28.1 2.6 9.0 0.0 12.2 14 0 0 14 14 14 1 Leucine Rich Repeat AAA_22 PF13401.6 EFA80600.1 - 0.012 15.9 0.0 0.14 12.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA80600.1 - 0.038 14.4 1.6 0.068 13.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 EFA80600.1 - 0.13 12.0 1.0 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 EFA80600.1 - 0.66 10.4 0.0 0.66 10.4 0.0 3.9 4 0 0 4 4 4 0 AAA domain KIF1B PF12423.8 EFA80601.1 - 0.022 15.2 1.1 0.2 12.1 1.1 2.9 1 0 0 1 1 1 0 Kinesin protein 1B HEV_ORF1 PF02444.16 EFA80601.1 - 0.081 13.5 5.3 0.14 12.7 3.7 2.3 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) DUF2845 PF11006.8 EFA80601.1 - 0.59 10.3 0.0 0.59 10.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2845) Pyr_redox_2 PF07992.14 EFA80603.1 - 3.3e-67 226.8 15.4 6.4e-67 225.8 14.5 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFA80603.1 - 3.9e-39 133.3 0.1 1.1e-38 131.8 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFA80603.1 - 7.6e-20 71.3 18.4 1.8e-18 66.9 3.4 3.5 4 0 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFA80603.1 - 8.6e-09 35.2 1.3 8.6e-09 35.2 1.3 4.7 4 2 1 6 6 6 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFA80603.1 - 1.5e-06 27.7 2.9 1.5e-06 27.7 2.9 3.6 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFA80603.1 - 6.1e-06 25.6 1.1 6.1e-06 25.6 1.1 3.5 2 1 2 4 4 4 1 FAD binding domain NAD_binding_8 PF13450.6 EFA80603.1 - 1.1e-05 25.5 4.4 0.00049 20.3 1.2 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFA80603.1 - 1.7e-05 24.1 0.9 1.7e-05 24.1 0.9 4.7 5 1 0 5 5 5 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFA80603.1 - 7.4e-05 21.6 0.7 7.4e-05 21.6 0.7 4.4 4 1 1 5 5 5 2 HI0933-like protein AlaDh_PNT_C PF01262.21 EFA80603.1 - 8.1e-05 22.0 9.3 0.0059 15.9 1.8 2.9 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain DUF3439 PF11921.8 EFA80603.1 - 0.0018 18.2 20.4 0.089 12.8 5.1 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF3439) Thi4 PF01946.17 EFA80603.1 - 0.0023 17.2 0.4 0.0023 17.2 0.4 2.8 2 1 1 3 3 3 1 Thi4 family 3HCDH_N PF02737.18 EFA80603.1 - 0.0048 16.8 1.1 0.0048 16.8 1.1 2.9 4 0 0 4 4 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EFA80603.1 - 0.0081 15.4 9.4 0.069 12.4 2.9 2.7 2 0 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.24 EFA80603.1 - 0.062 12.6 3.2 3.1 7.0 0.2 3.4 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EFA80603.1 - 0.34 9.9 4.7 1.3 7.9 0.1 2.8 2 1 1 3 3 3 0 Lycopene cyclase protein AcetDehyd-dimer PF09290.11 EFA80603.1 - 3.8 7.7 5.7 2.9 8.1 1.3 2.7 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation NAD_binding_7 PF13241.6 EFA80603.1 - 5.2 7.6 9.6 8.6 6.9 0.4 3.7 4 0 0 4 4 3 0 Putative NAD(P)-binding KH_6 PF15985.5 EFA80604.1 - 8.7e-11 42.0 0.0 1.7e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 EFA80604.1 - 1.2e-10 41.0 0.0 2e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region DUF4611 PF15387.6 EFA80604.1 - 0.055 13.7 1.6 0.14 12.4 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_A_exoN PF18305.1 EFA80604.1 - 0.22 11.8 0.7 0.78 10.1 0.0 2.2 3 0 0 3 3 3 0 3' to 5' exonuclease C-terminal domain EXOSC1 PF10447.9 EFA80604.1 - 3.4 8.3 5.8 1.7 9.3 0.1 3.2 3 2 2 5 5 5 0 Exosome component EXOSC1/CSL4 Mito_carr PF00153.27 EFA80605.1 - 1.3e-67 223.8 2.0 3.1e-22 78.3 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein SapB_1 PF05184.15 EFA80606.1 - 7.7e-20 70.5 8.4 8.9e-10 38.4 0.3 3.5 3 0 0 3 3 3 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA80606.1 - 3.2e-17 62.3 7.3 4.2e-10 39.6 0.6 3.1 3 0 0 3 3 3 2 Saposin-like type B, region 2 SEO_C PF14577.6 EFA80606.1 - 0.025 14.0 1.7 0.05 13.0 1.7 1.4 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Cupin_8 PF13621.6 EFA80607.1 - 3.9e-25 89.0 0.2 6.8e-25 88.2 0.2 1.3 1 0 0 1 1 1 1 Cupin-like domain SapB_1 PF05184.15 EFA80607.1 - 5.4e-15 55.1 8.5 3.5e-12 46.1 1.7 3.7 4 0 0 4 4 4 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA80607.1 - 1.4e-13 50.7 0.7 8.8e-12 44.9 0.7 2.9 2 0 0 2 2 2 1 Saposin-like type B, region 2 DUF2722 PF10846.8 EFA80607.1 - 0.0063 15.5 0.7 0.0063 15.5 0.7 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF4207 PF13904.6 EFA80607.1 - 0.15 11.7 15.5 0.29 10.8 5.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) RAB3GAP2_N PF14655.6 EFA80607.1 - 2.5 7.3 7.9 4.1 6.6 2.6 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus HATPase_c PF02518.26 EFA80608.1 - 9.9e-52 174.2 4.8 7.3e-25 87.7 0.0 3.2 3 0 0 3 3 3 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA80608.1 - 1.7e-44 150.6 0.9 4.5e-25 88.0 0.0 2.9 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 EFA80608.1 - 6.7e-32 109.3 4.6 4.8e-15 55.3 0.1 3.5 3 0 0 3 3 3 2 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EFA80608.1 - 0.00025 21.2 0.0 0.00098 19.3 0.0 2.1 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 EFA80608.1 - 0.00037 20.4 5.0 0.74 9.7 0.1 4.8 3 2 0 3 3 3 1 GHKL domain HATPase_c_2 PF13581.6 EFA80608.1 - 0.0015 18.5 0.0 0.13 12.2 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain PAS_4 PF08448.10 EFA80608.1 - 0.0016 18.7 0.0 0.0054 17.0 0.0 1.9 2 0 0 2 2 2 1 PAS fold NOD PF06816.13 EFA80608.1 - 0.022 14.4 0.6 1.6 8.4 0.1 2.6 2 0 0 2 2 2 0 NOTCH protein DUF724 PF05266.14 EFA80608.1 - 0.06 13.2 9.3 0.18 11.6 3.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Spc7 PF08317.11 EFA80608.1 - 0.16 10.8 13.2 0.048 12.5 5.0 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein OmpH PF03938.14 EFA80608.1 - 0.26 11.6 7.0 10 6.5 0.1 2.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Spore_III_AB PF09548.10 EFA80608.1 - 0.36 10.9 3.9 0.22 11.6 1.1 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) AAA_23 PF13476.6 EFA80608.1 - 0.66 10.5 6.4 8.5 6.8 2.1 3.4 3 0 0 3 3 3 0 AAA domain PI3K_P85_iSH2 PF16454.5 EFA80608.1 - 2.3 7.8 13.5 0.27 10.8 5.5 2.8 3 0 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF5082 PF16888.5 EFA80608.1 - 2.4 8.4 9.8 0.92 9.8 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) FNIP PF05725.12 EFA80609.1 - 1e-49 166.4 54.6 3.1e-11 43.3 0.1 14.6 12 2 4 17 17 17 8 FNIP Repeat Kelch_6 PF13964.6 EFA80609.1 - 1.1e-07 31.9 1.5 0.0013 18.9 0.0 3.9 3 0 0 3 3 3 2 Kelch motif F-box_5 PF18511.1 EFA80609.1 - 1.2e-07 31.1 2.4 0.0004 19.9 0.1 2.6 2 0 0 2 2 2 2 F-box F-box-like PF12937.7 EFA80609.1 - 0.00027 20.8 0.9 0.57 10.1 0.2 2.9 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EFA80609.1 - 0.008 16.0 7.5 0.11 12.3 0.6 3.4 3 0 0 3 3 3 2 F-box domain Kelch_1 PF01344.25 EFA80609.1 - 0.05 13.2 0.7 0.37 10.4 0.4 2.4 2 0 0 2 2 2 0 Kelch motif Snapin_Pallidin PF14712.6 EFA80609.1 - 0.11 12.9 2.2 0.37 11.2 2.2 1.9 1 0 0 1 1 1 0 Snapin/Pallidin zf-H2C2_5 PF13909.6 EFA80609.1 - 0.25 11.2 1.1 0.63 9.9 1.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Kelch_5 PF13854.6 EFA80609.1 - 2.4 8.2 6.5 2.8 8.0 0.1 3.3 3 0 0 3 3 3 0 Kelch motif PCRF PF03462.18 EFA80609.1 - 4.5 7.1 4.6 56 3.5 0.0 2.6 2 1 0 2 2 2 0 PCRF domain Dimer_Tnp_hAT PF05699.14 EFA80610.1 - 5e-14 51.9 0.2 7.9e-14 51.2 0.2 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Laminin_G_3 PF13385.6 EFA80611.1 - 2.2e-17 63.6 2.9 2.2e-17 63.6 2.9 2.9 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Endotoxin_N PF03945.14 EFA80611.1 - 3.2e-14 53.2 0.7 6.9e-14 52.1 0.7 1.6 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Laminin_G_2 PF02210.24 EFA80611.1 - 4.1e-10 40.3 0.0 1.1e-09 38.9 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain Ricin_B_lectin PF00652.22 EFA80611.1 - 3.2e-09 37.1 1.4 0.00014 22.1 0.1 2.5 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Laminin_G_1 PF00054.23 EFA80611.1 - 0.0005 20.3 0.0 0.001 19.3 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain CDtoxinA PF03498.14 EFA80611.1 - 0.00053 19.6 1.8 0.2 11.2 0.0 2.7 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain Pentaxin PF00354.17 EFA80611.1 - 0.001 18.8 0.7 0.019 14.6 0.2 2.4 2 0 0 2 2 2 1 Pentaxin family RicinB_lectin_2 PF14200.6 EFA80611.1 - 0.0035 18.0 5.4 1.5 9.6 0.0 4.1 3 1 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like Pkinase PF00069.25 EFA80612.1 - 5.8e-32 111.1 0.4 5.8e-32 111.1 0.4 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80612.1 - 7.3e-15 54.9 1.5 9.3e-15 54.6 0.1 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kelch_6 PF13964.6 EFA80612.1 - 6.6e-12 45.3 0.4 7.8e-05 22.8 0.0 4.8 4 0 0 4 4 4 2 Kelch motif FNIP PF05725.12 EFA80612.1 - 1.1e-11 44.7 21.8 8.7e-09 35.4 0.5 7.9 6 2 1 7 7 7 2 FNIP Repeat Kelch_1 PF01344.25 EFA80612.1 - 0.0062 16.1 0.3 2.6 7.7 0.0 3.5 3 0 0 3 3 3 1 Kelch motif PARP_reg PF02877.14 EFA80612.1 - 0.032 14.3 3.2 0.091 12.9 3.2 1.8 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase, regulatory domain Kelch_5 PF13854.6 EFA80612.1 - 0.11 12.5 1.2 5.4 7.1 0.0 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA80612.1 - 0.13 12.3 3.5 30 4.7 0.1 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Snapin_Pallidin PF14712.6 EFA80612.1 - 0.13 12.7 2.7 0.4 11.1 2.7 1.8 1 0 0 1 1 1 0 Snapin/Pallidin Laminin_G_3 PF13385.6 EFA80613.1 - 1.2e-18 67.7 3.3 1.2e-18 67.7 3.3 3.0 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Endotoxin_N PF03945.14 EFA80613.1 - 1.5e-14 54.3 0.7 3.3e-14 53.1 0.7 1.6 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Ricin_B_lectin PF00652.22 EFA80613.1 - 4.4e-11 43.1 4.2 1.3e-07 31.9 0.9 2.6 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Laminin_G_2 PF02210.24 EFA80613.1 - 8.7e-10 39.3 0.0 2.2e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain CDtoxinA PF03498.14 EFA80613.1 - 0.00028 20.5 1.5 0.19 11.3 0.0 2.6 2 0 0 2 2 2 2 Cytolethal distending toxin A/C domain Pentaxin PF00354.17 EFA80613.1 - 0.0005 19.8 0.9 0.0095 15.6 0.2 2.4 2 0 0 2 2 2 1 Pentaxin family Laminin_G_1 PF00054.23 EFA80613.1 - 0.00069 19.8 0.0 0.0014 18.9 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain RicinB_lectin_2 PF14200.6 EFA80613.1 - 0.079 13.7 9.4 1.6 9.5 0.0 4.5 5 1 0 5 5 5 0 Ricin-type beta-trefoil lectin domain-like Pkinase PF00069.25 EFA80614.1 - 2.7e-73 246.6 0.7 4.9e-73 245.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80614.1 - 1.1e-31 110.1 0.1 2.1e-31 109.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFA80614.1 - 0.00098 18.2 0.0 0.00098 18.2 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFA80614.1 - 0.025 13.4 2.3 1.5 7.5 0.0 2.6 3 0 0 3 3 3 0 Fungal protein kinase EPL1 PF10513.9 EFA80614.1 - 3.8 7.9 20.4 5.9 7.3 1.8 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 EFA80614.1 - 4.6 7.2 9.5 0.89 9.6 1.9 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PNISR PF15996.5 EFA80614.1 - 5.5 7.2 14.9 0.92 9.8 6.7 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR FAM76 PF16046.5 EFA80614.1 - 8.1 5.7 18.5 8.1 5.7 7.7 2.2 2 0 0 2 2 2 0 FAM76 protein FNIP PF05725.12 EFA80615.1 - 2.9e-35 120.2 28.7 5.4e-16 58.5 0.7 8.8 6 3 1 8 8 8 6 FNIP Repeat F-box_5 PF18511.1 EFA80615.1 - 4.6e-06 26.1 0.2 9e-06 25.2 0.2 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80615.1 - 0.058 13.3 0.1 0.23 11.4 0.1 2.0 1 0 0 1 1 1 0 F-box-like PH_TFIIH PF08567.11 EFA80616.1 - 1.6e-18 66.8 0.3 4.8e-18 65.3 0.3 1.8 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 EFA80616.1 - 1.1e-14 54.1 3.3 1.4e-11 44.3 0.2 3.2 3 0 0 3 3 3 2 BSD domain Vps36_ESCRT-II PF11605.8 EFA80616.1 - 0.023 14.9 0.1 0.082 13.1 0.0 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 DNAJ_related PF12339.8 EFA80616.1 - 0.066 13.4 1.1 0.28 11.4 0.2 2.3 2 0 0 2 2 2 0 DNA-J related protein FNIP PF05725.12 EFA80618.1 - 7.9e-23 80.4 26.9 7.3e-08 32.4 0.3 6.6 4 2 2 6 6 6 5 FNIP Repeat FNIP PF05725.12 EFA80619.1 - 3.1e-33 113.7 30.8 2.5e-11 43.5 0.1 9.4 7 2 2 10 10 10 8 FNIP Repeat FNIP PF05725.12 EFA80620.1 - 1.2e-26 92.6 36.2 1.1e-10 41.5 0.2 10.3 8 3 3 11 11 11 4 FNIP Repeat F-box PF00646.33 EFA80620.1 - 0.0014 18.5 7.9 0.23 11.4 0.4 3.0 3 0 0 3 3 3 2 F-box domain F-box_5 PF18511.1 EFA80620.1 - 0.056 13.0 0.1 0.34 10.5 0.1 2.1 2 0 0 2 2 2 0 F-box F-box-like PF12937.7 EFA80620.1 - 0.086 12.7 1.2 2.7 8.0 0.1 2.6 2 0 0 2 2 2 0 F-box-like Pallilysin PF18663.1 EFA80620.1 - 0.98 9.4 6.2 11 6.0 0.4 3.0 3 0 0 3 3 3 0 Pallilysin beta barrel domain TPR_17 PF13431.6 EFA80621.1 - 1.2e-94 304.1 20.1 3.5e-09 36.4 0.0 12.4 12 0 0 12 12 12 12 Tetratricopeptide repeat TPR_11 PF13414.6 EFA80621.1 - 3.8e-19 68.1 33.1 0.0014 18.3 0.3 11.2 12 0 0 12 12 12 8 TPR repeat DUF3085 PF11284.8 EFA80621.1 - 0.0016 18.7 0.0 3.2 8.1 0.0 4.1 3 2 1 4 4 4 1 Protein of unknown function (DUF3085) ChapFlgA PF13144.6 EFA80621.1 - 0.19 11.8 0.5 14 5.7 0.0 3.7 4 1 1 5 5 5 0 Chaperone for flagella basal body P-ring formation S-l_SbsC_C PF18316.1 EFA80621.1 - 0.23 12.0 5.5 0.19 12.2 0.4 3.5 3 2 2 5 5 5 0 S-layer protein SbsC C-terminal domain TPR_2 PF07719.17 EFA80621.1 - 0.34 11.1 15.5 1.5e+02 2.9 0.0 9.2 10 0 0 10 10 10 0 Tetratricopeptide repeat ProQ_C PF17516.2 EFA80621.1 - 0.61 9.6 1.8 6.1 6.3 0.1 3.1 3 0 0 3 3 3 0 ProQ C-terminal domain TPR_19 PF14559.6 EFA80621.1 - 0.64 10.6 2.3 50 4.5 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Anth_Ig PF05587.13 EFA80621.1 - 3.4 8.0 6.6 21 5.5 0.0 4.8 6 0 0 6 6 6 0 Anthrax receptor extracellular domain Acyl_transf_1 PF00698.21 EFA80623.1 - 6.5e-29 101.4 0.0 9.3e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain DUF1522 PF07482.11 EFA80623.1 - 0.18 12.1 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1522) DAP PF15228.6 EFA80624.1 - 0.028 15.6 2.3 0.043 15.0 2.3 1.3 1 1 0 1 1 1 0 Death-associated protein HAD_SAK_1 PF10307.9 EFA80625.1 - 7.8e-47 159.7 0.0 1.2e-46 159.1 0.0 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins tRNA_lig_CPD PF08302.11 EFA80625.1 - 0.019 14.4 1.0 2.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain HAD PF12710.7 EFA80625.1 - 0.12 12.8 0.0 2 8.8 0.0 2.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFA80625.1 - 0.48 10.5 5.1 24 4.9 0.0 3.6 4 0 0 4 4 4 0 Haloacid dehalogenase-like hydrolase Metallophos PF00149.28 EFA80626.1 - 5.8e-16 59.6 0.5 1.2e-15 58.6 0.5 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SapB_1 PF05184.15 EFA80626.1 - 5.2e-05 23.2 0.3 0.00011 22.1 0.3 1.6 1 0 0 1 1 1 1 Saposin-like type B, region 1 FANCI_S3 PF14677.6 EFA80626.1 - 0.078 12.7 0.3 0.17 11.6 0.3 1.6 1 0 0 1 1 1 0 FANCI solenoid 3 ABC_membrane_2 PF06472.15 EFA80627.1 - 2e-96 322.5 0.5 2.8e-96 322.0 0.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFA80627.1 - 2.8e-18 66.8 0.0 7.2e-18 65.4 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EFA80627.1 - 0.00019 22.0 0.0 0.0079 16.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EFA80627.1 - 0.00029 20.3 0.0 0.047 13.1 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA80627.1 - 0.00035 20.2 0.0 0.00087 19.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFA80627.1 - 0.00087 19.2 0.0 0.0027 17.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SbmA_BacA PF05992.12 EFA80627.1 - 0.0036 16.8 0.0 0.0079 15.7 0.0 1.5 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane PF00664.23 EFA80627.1 - 0.0043 16.8 0.1 0.0088 15.7 0.1 1.6 1 1 0 1 1 1 1 ABC transporter transmembrane region ATPase_2 PF01637.18 EFA80627.1 - 0.063 13.2 0.1 2.4 8.0 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Adeno_IVa2 PF02456.15 EFA80627.1 - 0.067 12.0 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein DUF815 PF05673.13 EFA80627.1 - 0.087 12.0 0.0 0.24 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_27 PF13514.6 EFA80627.1 - 0.093 12.3 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain MutS_V PF00488.21 EFA80627.1 - 0.11 12.6 0.1 6.7 6.7 0.0 2.7 2 1 0 2 2 2 0 MutS domain V AAA_18 PF13238.6 EFA80627.1 - 0.11 13.0 0.0 0.49 10.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA80627.1 - 0.13 12.6 0.0 0.48 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain LPMO_10 PF03067.15 EFA80628.1 - 0.0042 17.8 1.7 0.0075 16.9 1.7 1.4 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading bZIP_1 PF00170.21 EFA80629.1 - 5.2e-07 29.7 10.0 5.2e-07 29.7 10.0 3.2 4 0 0 4 4 4 1 bZIP transcription factor bZIP_2 PF07716.15 EFA80629.1 - 9e-07 28.9 11.2 9e-07 28.9 11.2 4.5 4 1 1 5 5 5 1 Basic region leucine zipper Astro_capsid_p PF12226.8 EFA80630.1 - 0.0013 18.0 6.3 0.0014 17.8 6.3 1.0 1 0 0 1 1 1 1 Turkey astrovirus capsid protein RXT2_N PF08595.11 EFA80630.1 - 0.027 14.5 5.7 0.046 13.7 5.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF688 PF05097.12 EFA80630.1 - 0.11 11.6 1.7 0.12 11.6 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF688) NOA36 PF06524.12 EFA80630.1 - 0.49 9.7 13.5 0.54 9.5 13.5 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EFA80630.1 - 1.4 6.9 13.2 1.6 6.7 13.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Cytomega_TRL10 PF06084.11 EFA80630.1 - 1.7 8.6 6.7 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein Pes-10 PF07149.11 EFA80630.1 - 5 6.1 13.9 0.75 8.8 10.3 1.5 2 0 0 2 2 2 0 Pes-10 DUF2457 PF10446.9 EFA80630.1 - 6.9 5.7 16.7 8.3 5.4 16.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DPBB_1 PF03330.18 EFA80631.1 - 0.03 14.6 0.8 0.4 11.0 0.8 2.5 1 1 0 1 1 1 0 Lytic transglycolase IBR PF01485.21 EFA80632.1 - 1.7e-14 53.8 53.9 2.8e-10 40.3 5.2 3.8 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFA80632.1 - 3.7e-06 27.1 13.7 3.7e-06 27.1 13.7 4.0 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA80632.1 - 8.3e-05 22.5 10.1 8.3e-05 22.5 10.1 4.1 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA80632.1 - 0.00018 21.3 16.3 0.00018 21.3 16.3 4.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA80632.1 - 0.0039 17.0 10.3 0.0039 17.0 10.3 5.1 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Peptidase_A22B PF04258.13 EFA80633.1 - 3.6e-86 289.2 14.7 5.3e-86 288.7 14.7 1.2 1 0 0 1 1 1 1 Signal peptide peptidase CBM49 PF09478.10 EFA80633.1 - 9.2e-12 45.1 0.4 9.2e-12 45.1 0.4 2.1 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 SPP PF06550.11 EFA80633.1 - 0.0074 15.8 13.2 0.087 12.3 13.2 2.3 1 1 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease DUF2393 PF09624.10 EFA80633.1 - 0.021 14.8 1.7 0.065 13.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) AIRC PF00731.20 EFA80634.1 - 2.8e-62 208.7 2.6 7.2e-62 207.3 2.6 1.8 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EFA80634.1 - 1.6e-50 171.0 0.1 4.4e-50 169.6 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain SAICAR_synt PF01259.18 EFA80634.1 - 6.3e-50 170.1 0.0 1.1e-49 169.4 0.0 1.3 1 0 0 1 1 1 1 SAICAR synthetase PurK_C PF17769.1 EFA80634.1 - 1.6e-14 53.3 0.1 3.8e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 EFA80634.1 - 0.0011 18.6 0.0 0.0025 17.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EFA80634.1 - 0.0016 18.0 0.1 0.039 13.5 0.0 2.6 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus PALP PF00291.25 EFA80634.1 - 0.022 14.2 0.0 0.022 14.2 0.0 2.0 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme GARS_A PF01071.19 EFA80634.1 - 0.03 14.1 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 2-Hacid_dh_C PF02826.19 EFA80634.1 - 0.1 12.0 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Miga PF10265.9 EFA80634.1 - 1.8 7.5 7.1 3.3 6.6 7.1 1.3 1 0 0 1 1 1 0 Mitoguardin XRN1_D1 PF18332.1 EFA80635.1 - 3.4e-21 75.9 0.0 3.4e-21 75.9 0.0 3.8 3 1 0 4 4 4 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 EFA80635.1 - 6e-19 67.9 0.2 3.9e-17 62.1 0.1 2.5 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN_M PF17846.1 EFA80635.1 - 2.3e-17 63.1 0.0 2.3e-17 63.1 0.0 4.2 3 1 0 3 3 3 1 Xrn1 helical domain XRN1_D2_D3 PF18334.1 EFA80635.1 - 6.6e-07 29.4 0.0 1.1e-05 25.5 0.0 3.1 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain ecTbetaR2 PF08917.10 EFA80635.1 - 0.28 11.1 3.1 0.3 11.0 1.2 2.1 2 0 0 2 2 2 0 Transforming growth factor beta receptor 2 ectodomain XRN_N PF03159.18 EFA80636.1 - 1.3e-86 290.0 0.0 2.4e-86 289.1 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus CTP_transf_like PF01467.26 EFA80636.1 - 0.004 17.4 0.1 0.015 15.5 0.1 2.0 1 1 0 1 1 1 1 Cytidylyltransferase-like SR-25 PF10500.9 EFA80636.1 - 0.0041 16.8 12.6 0.0081 15.8 12.6 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4614 PF15391.6 EFA80636.1 - 0.011 15.7 4.9 0.02 14.9 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PAP1 PF08601.10 EFA80636.1 - 0.017 14.9 8.9 0.023 14.5 8.9 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 DUF4698 PF15769.5 EFA80636.1 - 0.028 13.5 3.7 0.039 13.0 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Macoilin PF09726.9 EFA80636.1 - 0.17 10.4 11.1 0.22 10.1 11.1 1.1 1 0 0 1 1 1 0 Macoilin family DUF1635 PF07795.11 EFA80636.1 - 6.5 6.5 8.6 15 5.4 8.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) RabGAP-TBC PF00566.18 EFA80637.1 - 1.7e-53 181.5 5.5 1.7e-53 181.5 5.5 2.3 3 0 0 3 3 3 1 Rab-GTPase-TBC domain NERD PF08378.11 EFA80637.1 - 0.072 13.6 0.1 0.27 11.7 0.1 2.0 1 0 0 1 1 1 0 Nuclease-related domain Shisa PF13908.6 EFA80637.1 - 0.13 12.5 2.4 0.55 10.5 0.1 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator RNA_polI_A14 PF08203.11 EFA80637.1 - 7.6 7.3 10.0 8.8 7.1 3.9 3.2 3 0 0 3 3 3 0 Yeast RNA polymerase I subunit RPA14 DUF1294 PF06961.13 EFA80638.1 - 5.3e-19 68.2 0.8 5.3e-19 68.2 0.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1294) Exonuc_VII_L PF02601.15 EFA80638.1 - 0.018 14.6 3.6 0.017 14.7 3.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EFA80638.1 - 0.085 12.2 1.1 0.11 11.8 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4834 PF16118.5 EFA80638.1 - 0.28 12.2 5.5 0.45 11.5 5.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) O-antigen_lig PF13425.6 EFA80638.1 - 0.84 8.4 3.3 1.1 7.9 3.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF1517 PF07466.11 EFA80638.1 - 1.9 8.5 9.2 4.8 7.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1517) MAP17 PF15807.5 EFA80638.1 - 2.6 8.3 7.9 6.7 7.0 7.9 1.6 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EOS1 PF12326.8 EFA80638.1 - 2.8 7.8 4.8 4.1 7.3 4.8 1.3 1 1 0 1 1 1 0 N-glycosylation protein Brix PF04427.18 EFA80639.1 - 4.1e-23 82.5 0.5 4.1e-23 82.5 0.5 1.8 2 0 0 2 2 2 1 Brix domain RabGAP-TBC PF00566.18 EFA80640.1 - 1.4e-35 122.9 9.3 1.4e-35 122.9 9.3 5.7 4 3 1 5 5 5 1 Rab-GTPase-TBC domain Mt_ATP-synt_D PF05873.12 EFA80640.1 - 0.2 11.5 7.0 4.7 7.0 0.0 2.8 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) OSCP PF00213.18 EFA80641.1 - 2e-18 67.1 0.4 2e-18 67.1 0.4 2.1 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit DUF4441 PF14536.6 EFA80641.1 - 2.7 8.2 8.1 3.3 7.9 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4441) Branch PF02485.21 EFA80643.1 - 1.4e-16 60.8 3.3 1.4e-16 60.8 3.3 2.7 2 1 0 2 2 2 1 Core-2/I-Branching enzyme DUF4874 PF16173.5 EFA80643.1 - 0.012 15.2 0.6 0.027 14.2 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) EGF_2 PF07974.13 EFA80643.1 - 0.1 13.0 3.0 0.19 12.1 3.0 1.4 1 0 0 1 1 1 0 EGF-like domain Chordopox_A13L PF05961.11 EFA80643.1 - 3.7 7.8 8.8 2.7 8.3 3.3 2.7 2 0 0 2 2 2 0 Chordopoxvirus A13L protein SIR2 PF02146.17 EFA80644.1 - 1.4e-26 93.5 1.4 8.9e-20 71.3 0.3 2.3 1 1 1 2 2 2 2 Sir2 family RAP-1 PF03085.15 EFA80644.1 - 0.092 12.4 0.2 0.23 11.1 0.1 1.7 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Endonuclease_5 PF04493.14 EFA80646.1 - 4.8e-62 209.1 0.0 7.7e-62 208.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease V SHOCT PF09851.9 EFA80646.1 - 0.067 12.9 0.2 0.14 11.9 0.2 1.6 1 1 0 1 1 1 0 Short C-terminal domain DMAP_binding PF06464.11 EFA80646.1 - 2.8 8.8 14.4 0.1 13.4 2.2 2.5 2 0 0 2 2 2 0 DMAP1-binding Domain Pkinase PF00069.25 EFA80647.1 - 8.8e-70 235.1 0.0 1.3e-69 234.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80647.1 - 2e-36 125.6 0.0 4e-36 124.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.19 EFA80647.1 - 2e-13 49.9 0.0 3.8e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EFA80647.1 - 1.3e-05 24.6 0.0 2.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFA80647.1 - 0.0023 17.0 0.1 0.0023 17.0 0.1 2.7 3 0 0 3 3 3 1 Haspin like kinase domain APH PF01636.23 EFA80647.1 - 0.0036 17.3 0.0 0.021 14.7 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFA80647.1 - 0.013 15.1 0.0 0.013 15.1 0.0 2.1 3 0 0 3 3 3 0 Choline/ethanolamine kinase Kdo PF06293.14 EFA80647.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_20 PF00728.22 EFA80648.1 - 2.8e-55 188.1 0.0 1.1e-52 179.6 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFA80648.1 - 0.00049 20.8 0.0 0.0012 19.5 0.0 1.8 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFA80648.1 - 0.011 16.5 0.0 0.022 15.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 PP2C_2 PF13672.6 EFA80649.1 - 2.8e-05 23.9 0.1 4.2e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C G-alpha PF00503.20 EFA80650.1 - 1.2e-111 373.3 6.9 2e-111 372.6 6.9 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA80650.1 - 7.5e-15 54.8 0.4 1.8e-11 43.8 0.0 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA80650.1 - 2.5e-06 27.0 1.3 0.00057 19.3 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA80650.1 - 1.3e-05 25.3 0.1 0.029 14.6 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA80650.1 - 0.057 13.5 0.0 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA80650.1 - 0.066 12.7 0.0 0.36 10.3 0.0 2.1 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain LolA PF03548.15 EFA80650.1 - 0.074 12.7 0.9 0.16 11.6 0.1 2.0 3 1 0 3 3 3 0 Outer membrane lipoprotein carrier protein LolA Epimerase PF01370.21 EFA80650.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AAA_29 PF13555.6 EFA80650.1 - 0.16 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CLTH PF10607.9 EFA80651.1 - 8.8e-32 110.0 0.4 8.8e-32 110.0 0.4 2.1 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EFA80651.1 - 2.1e-05 24.5 0.2 4.7e-05 23.3 0.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA80651.1 - 0.0032 17.4 0.2 0.007 16.3 0.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA80651.1 - 0.0066 16.3 0.8 0.026 14.4 0.8 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Lipoprotein_X PF03305.13 EFA80651.1 - 0.013 15.3 12.9 3.3 7.4 0.0 3.3 2 1 0 3 3 3 0 Mycoplasma MG185/MG260 protein zf-RING_2 PF13639.6 EFA80651.1 - 0.044 14.1 0.2 0.093 13.1 0.2 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.6 EFA80651.1 - 0.044 13.9 0.6 0.099 12.8 0.6 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING L31 PF09784.9 EFA80651.1 - 0.055 13.9 0.4 0.19 12.2 0.4 1.9 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 zf-C3HC4_3 PF13920.6 EFA80651.1 - 0.13 12.2 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ALMT PF11744.8 EFA80651.1 - 9.2 5.0 9.9 18 4.0 9.9 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter LRR_4 PF12799.7 EFA80652.1 - 9.8e-14 51.3 43.8 0.00024 21.4 0.4 8.3 7 2 1 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA80652.1 - 2e-11 43.5 31.7 2.5e-06 27.1 5.2 5.9 5 1 1 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 EFA80652.1 - 1.2e-07 31.4 21.8 0.00033 20.2 1.3 5.7 4 2 1 6 6 6 3 Leucine-rich repeat LRR_6 PF13516.6 EFA80652.1 - 0.0039 17.1 19.9 2.4 8.4 0.1 7.8 9 0 0 9 9 9 2 Leucine Rich repeat Pentapeptide_4 PF13599.6 EFA80652.1 - 0.093 12.9 1.3 0.31 11.2 0.1 2.6 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) LRR_2 PF07723.13 EFA80652.1 - 0.11 13.2 4.7 4.3 8.2 0.4 3.4 2 0 0 2 2 2 0 Leucine Rich Repeat ThiF PF00899.21 EFA80653.1 - 1e-50 172.4 0.0 1.4e-50 172.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 EFA80653.1 - 0.0022 17.4 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EFA80653.1 - 0.035 13.7 0.8 0.054 13.1 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HemeBinding_Shp PF11545.8 EFA80653.1 - 0.044 13.8 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Cell surface heme-binding protein Shp ECSIT PF06239.11 EFA80653.1 - 0.06 12.5 0.1 0.15 11.2 0.0 1.6 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway FAD_binding_3 PF01494.19 EFA80653.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EFA80653.1 - 0.17 12.2 0.0 0.83 9.9 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain Nop PF01798.18 EFA80654.1 - 4.6e-85 284.7 0.1 4.6e-85 284.7 0.1 2.7 3 1 0 3 3 3 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFA80654.1 - 5.2e-17 62.0 0.6 5.2e-17 62.0 0.6 3.4 2 1 0 2 2 2 1 NOP5NT (NUC127) domain Borrelia_P83 PF05262.11 EFA80654.1 - 1.1 7.6 40.2 1.3 7.4 39.8 1.4 1 1 0 1 1 1 0 Borrelia P83/100 protein Sulfotransfer_2 PF03567.14 EFA80655.1 - 2.8e-18 66.8 0.0 4e-08 33.5 0.0 3.3 2 1 0 2 2 2 2 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 EFA80655.1 - 5.8e-05 22.2 0.0 0.3 9.9 0.0 2.5 2 0 0 2 2 2 2 Galactose-3-O-sulfotransferase DUF3990 PF13151.6 EFA80655.1 - 0.0083 15.8 3.2 2.3 7.9 0.2 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3990) RNA12 PF10443.9 EFA80656.1 - 1.5e-53 182.1 4.5 6.2e-28 97.7 0.7 3.9 2 1 1 3 3 3 2 RNA12 protein RRM_1 PF00076.22 EFA80656.1 - 0.00056 19.7 0.0 0.002 17.9 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.17 EFA80656.1 - 0.0046 16.3 0.1 0.011 15.1 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_16 PF13191.6 EFA80656.1 - 0.11 12.8 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain TraI_2 PF07514.11 EFA80656.1 - 0.12 11.3 0.5 0.81 8.6 0.4 2.2 2 0 0 2 2 2 0 Putative helicase AAA_assoc_C PF09821.9 EFA80656.1 - 0.6 10.7 5.3 8.5 6.9 3.8 2.8 2 0 0 2 2 2 0 C-terminal AAA-associated domain NTP_transferase PF00483.23 EFA80657.1 - 4.3e-51 173.9 0.0 5.8e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EFA80657.1 - 7.8e-09 36.1 0.0 9.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 EFA80657.1 - 8.1e-09 34.9 6.6 1.6e-06 27.6 0.5 3.6 2 1 2 4 4 4 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 EFA80657.1 - 0.034 12.3 0.4 0.11 10.5 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EFA80657.1 - 0.054 13.3 5.4 0.18 11.6 0.3 3.6 3 1 1 4 4 4 0 Hexapeptide repeat of succinyl-transferase DUF257 PF03192.13 EFA80657.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 Cyclin_N PF00134.23 EFA80658.1 - 1.1e-35 122.1 0.1 1.1e-34 118.9 0.0 2.4 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFA80658.1 - 2.3e-19 69.7 3.1 2.5e-19 69.5 0.1 2.7 3 0 0 3 3 3 1 Cyclin, C-terminal domain TFIIB PF00382.19 EFA80658.1 - 0.098 12.7 0.1 18 5.5 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat PARP PF00644.20 EFA80659.1 - 9e-60 201.6 0.1 1e-58 198.2 0.0 2.6 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFA80659.1 - 5.8e-48 162.4 4.9 3.1e-47 160.1 1.7 2.8 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFA80659.1 - 3.5e-23 81.5 3.2 3.5e-23 81.5 3.2 2.5 2 0 0 2 2 2 1 WGR domain BRCT_2 PF16589.5 EFA80659.1 - 0.003 18.0 0.1 0.011 16.1 0.1 2.0 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RNase_PH PF01138.21 EFA80660.1 - 4.1e-23 82.3 0.1 1.2e-22 80.8 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFA80660.1 - 3.5e-12 46.2 0.0 8.8e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Sedlin_N PF04628.13 EFA80661.1 - 4.5e-30 104.5 0.6 5.2e-30 104.2 0.6 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EFA80661.1 - 1.2e-06 28.5 0.2 1.4e-06 28.3 0.2 1.2 1 0 0 1 1 1 1 Sybindin-like family DUF5042 PF16445.5 EFA80661.1 - 0.03 12.7 0.0 0.035 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5042) COMM_domain PF07258.14 EFA80662.1 - 4e-15 55.7 7.6 8.7e-15 54.6 7.6 1.6 1 0 0 1 1 1 1 COMM domain AAA_13 PF13166.6 EFA80662.1 - 0.0025 16.6 4.0 0.0029 16.3 4.0 1.1 1 0 0 1 1 1 1 AAA domain DUF1899 PF08953.11 EFA80662.1 - 0.064 13.1 0.1 11 6.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1899) DUF4061 PF13270.6 EFA80662.1 - 0.72 10.2 6.9 9.7 6.6 6.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4061) LRR_9 PF14580.6 EFA80663.1 - 6e-12 45.4 0.0 9.5e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EFA80663.1 - 2.1e-08 33.8 0.4 4.4e-08 32.8 0.4 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 EFA80663.1 - 2.7e-08 34.0 2.2 4.4e-06 26.9 0.5 1.9 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA80663.1 - 0.047 14.2 0.4 7.4 7.5 0.1 2.9 2 0 0 2 2 2 0 Leucine Rich Repeat DUF3557 PF12078.8 EFA80663.1 - 0.27 11.2 1.0 0.32 11.0 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3557) PRCC PF10253.9 EFA80663.1 - 8.4 7.1 12.6 17 6.1 12.6 1.5 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Hemerythrin PF01814.23 EFA80664.1 - 4.5e-12 46.7 0.4 6.9e-12 46.1 0.4 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Sec34 PF04136.15 EFA80664.1 - 0.028 14.3 0.6 1.4 8.8 0.0 2.4 1 1 0 2 2 2 0 Sec34-like family NPV_P10 PF05531.12 EFA80664.1 - 0.062 13.8 2.9 2.7 8.5 1.9 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein zf-C4H2 PF10146.9 EFA80664.1 - 0.086 13.1 0.5 0.11 12.8 0.5 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF5394 PF17372.2 EFA80664.1 - 0.12 11.9 3.2 0.17 11.4 3.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5394) Tweety PF04906.13 EFA80665.1 - 0.0003 19.6 7.8 0.002 16.9 7.7 2.1 1 1 0 1 1 1 1 Tweety TMEM173 PF15009.6 EFA80665.1 - 0.0025 17.0 0.2 0.0052 16.0 0.2 1.5 1 0 0 1 1 1 1 Transmembrane protein 173 4HB_MCP_1 PF12729.7 EFA80665.1 - 1.2 8.7 0.0 1.2 8.7 0.0 3.1 4 0 0 4 4 4 0 Four helix bundle sensory module for signal transduction Thioredoxin PF00085.20 EFA80666.1 - 7.5e-21 74.1 0.3 4.5e-13 49.1 0.1 2.6 2 0 0 2 2 2 2 Thioredoxin UBX PF00789.20 EFA80666.1 - 7.4e-12 45.3 0.0 1.5e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain ZZ PF00569.17 EFA80666.1 - 6e-11 42.0 7.4 1.1e-10 41.1 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type UBA PF00627.31 EFA80666.1 - 6.2e-08 32.4 0.1 1.2e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Thioredoxin_2 PF13098.6 EFA80666.1 - 2.6e-05 24.6 0.3 2.6e-05 24.6 0.3 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain C1_2 PF03107.16 EFA80666.1 - 0.00016 21.9 4.1 0.00044 20.5 4.1 1.8 1 0 0 1 1 1 1 C1 domain Thioredoxin_7 PF13899.6 EFA80666.1 - 0.00075 19.6 0.4 0.0018 18.4 0.4 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EFA80666.1 - 0.0019 18.1 3.1 0.053 13.4 0.1 2.5 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EFA80666.1 - 0.011 16.1 1.2 0.091 13.1 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_9 PF14595.6 EFA80666.1 - 0.027 14.2 0.1 0.027 14.2 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin Macoilin PF09726.9 EFA80666.1 - 0.14 10.7 25.3 0.0032 16.1 19.0 1.4 2 0 0 2 2 2 0 Macoilin family CEBP_ZZ PF16366.5 EFA80666.1 - 0.19 12.0 3.9 0.4 10.9 3.9 1.5 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain SSP160 PF06933.11 EFA80666.1 - 0.83 7.8 13.6 1.5 6.9 13.6 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RRM_1 PF00076.22 EFA80667.1 - 2.2e-24 85.1 0.1 1.4e-12 47.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA80667.1 - 0.0085 16.1 0.4 2.5 8.2 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EFA80667.1 - 0.019 15.0 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif DUF1877 PF08974.10 EFA80667.1 - 0.038 14.1 0.5 0.15 12.1 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1877) IL2 PF00715.17 EFA80667.1 - 0.52 10.2 6.1 0.84 9.6 4.6 2.1 1 1 0 1 1 1 0 Interleukin 2 Swi3 PF07962.12 EFA80669.1 - 4e-08 33.1 0.0 9e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Hamartin PF04388.12 EFA80669.1 - 4.4 5.9 25.4 1.7 7.2 23.0 1.4 1 1 0 1 1 1 0 Hamartin protein Stealth_CR2 PF11380.8 EFA80670.1 - 4.4e-39 133.0 1.7 1.1e-38 131.7 1.7 1.7 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EFA80670.1 - 5.7e-12 45.3 0.0 1.6e-11 43.9 0.0 1.8 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 EFA80670.1 - 1.7e-09 37.2 0.1 3.1e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 EFA80670.1 - 1.2e-08 34.7 0.0 2.5e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 FtsH_ext PF06480.15 EFA80670.1 - 0.023 15.0 0.2 0.066 13.6 0.2 1.8 1 0 0 1 1 1 0 FtsH Extracellular DUF2140 PF09911.9 EFA80670.1 - 0.51 9.9 4.5 5.3 6.5 2.4 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF1908 PF08926.11 EFA80670.1 - 1.2 8.1 6.8 3.8 6.5 1.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1908) Stealth_CR2 PF11380.8 EFA80672.1 - 4.2e-34 117.0 3.5 4.2e-34 117.0 3.5 2.2 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 FNIP PF05725.12 EFA80672.1 - 8.3e-22 77.1 14.4 3.3e-06 27.2 0.1 8.4 8 1 0 8 8 8 4 FNIP Repeat Stealth_CR3 PF17102.5 EFA80672.1 - 7.2e-14 51.4 0.0 7.2e-14 51.4 0.0 2.0 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 EFA80672.1 - 5.3e-13 48.5 0.1 5.3e-13 48.5 0.1 1.8 2 0 0 2 2 2 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 EFA80672.1 - 5.5e-13 48.6 0.0 1.2e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 Abhydrolase_6 PF12697.7 EFA80672.1 - 3e-10 41.1 0.0 6e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA80672.1 - 1.1e-06 28.5 0.0 4.1e-06 26.6 0.0 2.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EFA80672.1 - 0.006 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2498 PF10692.9 EFA80672.1 - 0.07 13.0 0.2 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2498) FerA PF08165.11 EFA80672.1 - 0.18 11.7 0.0 0.43 10.6 0.0 1.6 1 0 0 1 1 1 0 FerA (NUC095) domain Abhydrolase_6 PF12697.7 EFA80673.1 - 5.7e-11 43.4 0.0 6.6e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA80673.1 - 2.1e-06 27.6 0.1 3.4e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF3530 PF12048.8 EFA80673.1 - 0.00041 19.9 0.1 0.0052 16.3 0.0 2.0 1 1 0 2 2 2 1 Protein of unknown function (DUF3530) Abhydrolase_5 PF12695.7 EFA80673.1 - 0.0012 18.6 0.1 0.0023 17.7 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA80673.1 - 0.0036 16.6 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EFA80673.1 - 0.012 15.7 0.0 0.018 15.2 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.13 EFA80673.1 - 0.027 14.2 0.1 0.054 13.2 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein LIDHydrolase PF10230.9 EFA80673.1 - 0.027 14.0 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase tRNA-synt_2d PF01409.20 EFA80675.1 - 8e-51 172.9 2.3 6.4e-31 107.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EFA80675.1 - 5.7e-22 77.9 0.0 1.4e-21 76.7 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain ChW PF07538.11 EFA80676.1 - 6.1e-28 96.4 0.4 3.1e-08 33.4 0.5 3.2 3 0 0 3 3 3 3 Clostridial hydrophobic W DUF2559 PF10832.8 EFA80676.1 - 0.0046 17.0 1.6 2.7 8.1 0.0 3.8 4 0 0 4 4 4 2 Protein of unknown function (DUF2559) Herpes_UL6 PF01763.16 EFA80676.1 - 0.044 12.3 0.9 0.054 12.0 0.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Endotoxin_N PF03945.14 EFA80678.1 - 4.1e-13 49.6 0.3 6.5e-13 48.9 0.3 1.3 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain MBG_2 PF18676.1 EFA80678.1 - 4.7 7.9 6.6 65 4.3 0.1 2.9 2 0 0 2 2 2 0 MBG domain (YGX type) DDE_Tnp_4 PF13359.6 EFA80679.1 - 1e-09 38.3 0.0 1.3e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase PF00069.25 EFA80680.1 - 5e-41 140.8 1.3 2.7e-29 102.3 0.8 3.3 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80680.1 - 1.8e-20 73.4 0.2 1.9e-12 47.0 0.4 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase HEAT PF02985.22 EFA80680.1 - 0.0011 19.0 0.0 1.1 9.7 0.0 3.0 2 0 0 2 2 2 2 HEAT repeat Kinase-like PF14531.6 EFA80680.1 - 0.0018 17.6 0.4 0.077 12.3 0.4 2.5 2 0 0 2 2 2 1 Kinase-like HEAT_EZ PF13513.6 EFA80680.1 - 0.033 14.7 0.0 18 6.0 0.0 3.5 3 0 0 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.6 EFA80680.1 - 0.055 13.9 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 HEAT repeats RhoGEF PF00621.20 EFA80681.1 - 6.5e-35 121.0 3.3 6.5e-35 121.0 3.3 2.3 2 0 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 EFA80681.1 - 8.1e-09 35.6 0.0 3.3e-08 33.6 0.0 2.1 1 1 0 1 1 1 1 PH domain Pkinase PF00069.25 EFA80681.1 - 5.6e-06 25.9 0.1 1.6e-05 24.5 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 EFA80681.1 - 7.6e-06 26.4 0.0 2.7e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 EFA80681.1 - 0.00021 20.7 0.1 0.00048 19.5 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PH_5 PF15405.6 EFA80681.1 - 0.061 13.4 0.0 0.061 13.4 0.0 3.3 4 1 0 4 4 4 0 Pleckstrin homology domain Pkinase_Tyr PF07714.17 EFA80682.1 - 2e-12 47.0 0.0 2.3e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA80682.1 - 9.4e-10 38.3 0.0 1.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SNF2_N PF00176.23 EFA80683.1 - 6e-21 74.5 0.1 3.9e-12 45.6 0.0 2.9 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA80683.1 - 1e-12 48.3 0.0 8.8e-12 45.4 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SAM_1 PF00536.30 EFA80683.1 - 0.0013 19.1 0.9 0.0033 17.8 0.9 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EppA_BapA PF07268.11 EFA80684.1 - 0.015 15.2 0.6 0.077 12.9 0.6 1.9 1 1 0 1 1 1 0 Exported protein precursor (EppA/BapA) SdrD_B PF17210.3 EFA80686.1 - 0 1343.3 154.9 3.1e-25 88.6 3.1 24.7 24 1 0 24 24 24 24 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA80686.1 - 6.1e-196 635.3 133.0 5.5e-10 39.4 0.5 24.9 24 0 0 24 24 24 24 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA80686.1 - 1.3e-99 326.6 119.3 4.7e-06 26.8 0.2 25.0 22 2 2 24 24 24 23 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA80686.1 - 9.5e-84 275.5 104.3 8.4e-05 22.5 0.1 25.7 24 2 0 24 24 24 23 CarboxypepD_reg-like domain bMG3 PF11974.8 EFA80686.1 - 2.8e-63 210.4 22.9 0.00066 19.7 0.0 23.3 24 0 0 24 24 23 14 Bacterial alpha-2-macroglobulin MG3 domain DUF2012 PF09430.10 EFA80686.1 - 1.4e-45 154.4 18.9 0.089 12.9 0.0 23.5 24 0 0 24 24 24 10 Protein of unknown function (DUF2012) MetallophosN PF16371.5 EFA80686.1 - 7.5e-25 87.0 87.5 0.026 14.8 0.4 23.7 22 2 1 23 23 23 9 N terminal of Calcineurin-like phosphoesterase fn3_3 PF14686.6 EFA80686.1 - 1.1e-17 63.5 67.0 0.55 10.1 0.1 19.8 21 0 0 21 21 21 7 Polysaccharide lyase family 4, domain II Y_Y_Y PF07495.13 EFA80686.1 - 2.7e-14 52.9 61.6 0.014 15.3 0.3 16.7 17 0 0 17 17 17 6 Y_Y_Y domain Big_6 PF17936.1 EFA80686.1 - 3.1e-14 53.0 67.7 2.9 8.2 0.3 21.8 25 0 0 25 25 24 4 Bacterial Ig domain EMP24_GP25L PF01105.24 EFA80686.1 - 8.8e-13 48.6 9.9 1.5 8.7 0.0 13.3 16 1 1 17 17 16 2 emp24/gp25L/p24 family/GOLD DUF1416 PF07210.12 EFA80686.1 - 3.3e-11 42.9 0.8 5.5 6.9 0.1 10.1 13 0 0 13 13 11 3 Protein of unknown function (DUF1416) TTR-52 PF01060.23 EFA80686.1 - 3.7e-11 43.6 20.4 0.84 10.4 0.0 16.5 20 0 0 20 20 19 1 Transthyretin-like family DUF4198 PF10670.9 EFA80686.1 - 7.7e-08 33.0 23.7 2.3 8.5 0.0 13.9 16 1 0 17 17 15 2 Domain of unknown function (DUF4198) TcfC PF16967.5 EFA80686.1 - 3.6e-06 26.4 5.1 0.29 10.7 0.0 6.6 7 0 0 7 7 7 2 E-set like domain Big_1 PF02369.16 EFA80686.1 - 9.4e-06 25.6 161.8 0.097 12.7 0.1 27.3 27 3 3 30 30 28 10 Bacterial Ig-like domain (group 1) Dioxygenase_C PF00775.21 EFA80686.1 - 0.00014 21.4 61.6 0.55 9.6 0.1 18.1 22 1 0 22 22 22 4 Dioxygenase MG4 PF17789.1 EFA80686.1 - 0.0036 17.4 35.2 3.8 7.7 0.1 13.8 15 0 0 15 15 14 1 Macroglobulin domain MG4 DUF2606 PF10794.9 EFA80686.1 - 0.069 12.9 4.0 67 3.3 0.0 7.1 10 0 0 10 10 8 0 Protein of unknown function (DUF2606) ATP-synt_F6 PF05511.11 EFA80687.1 - 0.083 13.3 0.2 0.18 12.3 0.2 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 Reg_prop PF07494.11 EFA80687.1 - 0.16 12.3 0.4 15 6.3 0.0 3.7 3 0 0 3 3 3 0 Two component regulator propeller PRMT5_C PF17286.2 EFA80687.1 - 1 9.2 6.1 12 5.7 2.2 2.6 1 1 1 2 2 2 0 PRMT5 oligomerisation domain GST_C PF00043.25 EFA80688.1 - 1.7e-14 53.8 0.0 3.7e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFA80688.1 - 8.7e-14 51.6 0.0 1.8e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFA80688.1 - 1e-13 51.4 0.0 1.9e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA80688.1 - 1.9e-13 50.6 0.0 3.3e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA80688.1 - 1.5e-11 44.4 0.1 2.9e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA80688.1 - 1.6e-10 40.9 0.0 3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA80688.1 - 0.00018 21.3 0.0 0.00047 19.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EFA80688.1 - 0.048 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Glutaredoxin Pkinase PF00069.25 EFA80689.1 - 4.8e-74 249.0 0.0 6.8e-74 248.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80689.1 - 2.1e-36 125.5 0.0 3.1e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SR-25 PF10500.9 EFA80689.1 - 0.0002 21.0 12.1 0.0003 20.5 12.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RIO1 PF01163.22 EFA80689.1 - 0.008 15.8 0.1 0.018 14.7 0.1 1.5 1 0 0 1 1 1 1 RIO1 family DUF4603 PF15376.6 EFA80689.1 - 0.035 11.5 6.5 0.047 11.1 6.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Pkinase_fungal PF17667.1 EFA80689.1 - 0.056 12.2 4.0 2.1 7.0 0.0 2.8 3 0 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EFA80689.1 - 0.16 11.9 0.0 1.5 8.7 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family IMUP PF15761.5 EFA80689.1 - 0.25 12.0 8.0 0.44 11.3 8.0 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Macoilin PF09726.9 EFA80689.1 - 2.1 6.8 8.6 2.7 6.4 8.6 1.1 1 0 0 1 1 1 0 Macoilin family DENN PF02141.21 EFA80690.1 - 2.2e-27 96.2 5.1 3.6e-26 92.3 0.1 3.2 2 1 0 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 EFA80690.1 - 4.1e-07 30.6 3.4 1.4e-06 28.9 2.1 2.7 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 EFA80690.1 - 5e-05 23.2 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 EFA80690.1 - 0.0005 20.0 0.1 0.0015 18.5 0.1 1.8 1 0 0 1 1 1 1 Stabilization of polarity axis Dicty_CAR PF05462.11 EFA80690.1 - 0.1 11.7 0.5 0.77 8.8 0.1 2.2 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor Serinc PF03348.15 EFA80690.1 - 1.5 7.7 7.5 3.4 6.5 7.5 1.7 1 0 0 1 1 1 0 Serine incorporator (Serinc) PepSY_TM PF03929.16 EFA80690.1 - 3.5 7.2 4.0 6.6 6.3 4.0 1.5 1 0 0 1 1 1 0 PepSY-associated TM region Pro_isomerase PF00160.21 EFA80691.1 - 1.1e-22 81.1 0.6 4.1e-11 43.4 0.1 2.2 2 0 0 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Voltage_CLC PF00654.20 EFA80692.1 - 6.9e-77 259.1 20.9 6.9e-77 259.1 20.9 1.5 1 1 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 EFA80692.1 - 1.5e-06 28.5 1.2 0.0049 17.3 0.2 2.6 2 0 0 2 2 2 2 CBS domain DBD_Tnp_Hermes PF10683.9 EFA80692.1 - 0.037 13.7 0.0 0.096 12.4 0.0 1.6 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain OmpH PF03938.14 EFA80693.1 - 1.2 9.4 20.8 0.3 11.4 12.0 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Striatin PF08232.12 EFA80694.1 - 1.1e-32 113.8 5.2 1.1e-32 113.8 5.2 3.1 3 0 0 3 3 3 1 Striatin family WD40 PF00400.32 EFA80694.1 - 3.8e-31 106.7 19.2 1.8e-06 28.5 0.7 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80694.1 - 3.6e-09 36.8 0.0 0.086 13.1 0.0 4.9 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA80694.1 - 0.0017 17.4 0.0 1.7 7.5 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3439 PF11921.8 EFA80694.1 - 0.49 10.4 4.8 1.3 9.0 0.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) FNIP PF05725.12 EFA80696.1 - 8e-32 109.2 39.0 2.9e-06 27.3 0.1 13.9 9 3 2 13 13 13 10 FNIP Repeat CBM_3 PF00942.18 EFA80696.1 - 0.0085 16.5 0.0 5.4 7.5 0.0 3.5 3 0 0 3 3 3 2 Cellulose binding domain FNIP PF05725.12 EFA80697.1 - 2.6e-21 75.5 12.1 1.8e-09 37.6 0.1 8.1 6 1 2 8 8 8 4 FNIP Repeat FNIP PF05725.12 EFA80698.1 - 9.4e-23 80.1 11.7 4e-10 39.7 0.1 9.1 6 1 5 11 11 11 6 FNIP Repeat ArsA_HSP20 PF17886.1 EFA80698.1 - 0.057 13.0 0.2 1.2 8.8 0.0 3.0 3 0 0 3 3 3 0 HSP20-like domain found in ArsA FNIP PF05725.12 EFA80699.1 - 1.4e-18 66.8 23.9 4.3e-10 39.6 0.1 8.4 8 2 1 9 9 9 4 FNIP Repeat ArsA_HSP20 PF17886.1 EFA80699.1 - 0.05 13.2 0.1 0.28 10.8 0.0 2.4 2 0 0 2 2 2 0 HSP20-like domain found in ArsA Mak10 PF04112.13 EFA80700.1 - 1e-21 77.2 13.3 2e-18 66.4 0.0 3.9 3 1 1 4 4 4 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase EPL1 PF10513.9 EFA80700.1 - 0.00011 22.6 7.7 0.014 15.8 3.4 2.5 2 0 0 2 2 2 2 Enhancer of polycomb-like Spt20 PF12090.8 EFA80700.1 - 0.00056 19.6 22.8 0.0082 15.8 4.3 2.4 2 0 0 2 2 2 2 Spt20 family DDHD PF02862.17 EFA80700.1 - 0.0017 18.5 1.5 0.53 10.4 0.4 2.3 2 0 0 2 2 2 2 DDHD domain Senescence_reg PF04520.13 EFA80700.1 - 0.0051 17.7 0.9 0.28 12.0 0.1 2.3 2 0 0 2 2 2 1 Senescence regulator TFIIA PF03153.13 EFA80700.1 - 0.018 15.0 15.5 0.46 10.4 6.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AP3D1 PF06375.11 EFA80700.1 - 0.03 14.6 15.2 1.1 9.5 1.0 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 NARP1 PF12569.8 EFA80700.1 - 0.054 12.4 12.9 0.02 13.8 5.4 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 GAGA_bind PF06217.12 EFA80700.1 - 0.084 13.1 8.7 0.69 10.1 1.4 3.2 3 0 0 3 3 3 0 GAGA binding protein-like family Gti1_Pac2 PF09729.9 EFA80700.1 - 0.19 11.8 13.7 1.9 8.6 9.9 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Tim54 PF11711.8 EFA80700.1 - 0.22 10.3 10.0 1.7 7.3 7.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 EFA80700.1 - 0.28 11.2 4.8 5.6 6.9 1.4 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ctr PF04145.15 EFA80700.1 - 0.33 11.6 2.6 7.6 7.1 0.2 2.5 2 0 0 2 2 2 0 Ctr copper transporter family Pex14_N PF04695.13 EFA80700.1 - 0.47 11.1 14.9 3.2 8.4 5.7 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 EFA80700.1 - 0.5 9.1 12.3 6 5.5 0.0 2.2 2 0 0 2 2 2 0 Presenilin Connexin PF00029.19 EFA80700.1 - 0.55 9.9 8.7 2.9 7.6 4.1 2.3 2 0 0 2 2 2 0 Connexin Rtf2 PF04641.12 EFA80700.1 - 0.58 9.5 14.0 3.8 6.8 11.0 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger FAM60A PF15396.6 EFA80700.1 - 0.72 9.8 12.3 0.98 9.4 4.9 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF5427 PF10310.9 EFA80700.1 - 0.74 8.7 13.5 0.33 9.9 6.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5427) EOS1 PF12326.8 EFA80700.1 - 0.89 9.5 3.0 29 4.5 1.1 2.4 2 0 0 2 2 2 0 N-glycosylation protein CCDC53 PF10152.9 EFA80700.1 - 0.94 9.9 13.1 5.6 7.4 0.0 2.9 3 0 0 3 3 2 0 Subunit CCDC53 of WASH complex IHABP4_N PF16174.5 EFA80700.1 - 1.1 9.9 18.7 0.21 12.2 8.6 2.2 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Pet20 PF08692.10 EFA80700.1 - 1.2 9.8 11.2 1.7 9.4 4.5 2.6 2 0 0 2 2 2 0 Mitochondrial protein Pet20 BORG_CEP PF14957.6 EFA80700.1 - 1.3 10.2 8.0 5.8 8.1 2.5 2.5 2 0 0 2 2 2 0 Cdc42 effector DUF4770 PF15994.5 EFA80700.1 - 2 8.6 18.4 0.046 14.0 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Coilin_N PF15862.5 EFA80700.1 - 2.3 8.0 17.1 0.62 9.9 2.6 3.0 3 0 0 3 3 3 0 Coilin N-terminus CLN3 PF02487.17 EFA80700.1 - 3.8 6.5 8.7 6.4 5.7 3.0 2.2 2 0 0 2 2 2 0 CLN3 protein CPSF100_C PF13299.6 EFA80700.1 - 4.5 7.4 12.5 4.9 7.3 5.1 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 EFA80700.1 - 8.2 6.8 16.1 1.3 9.5 4.5 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 CobT PF06213.12 EFA80700.1 - 10 5.4 18.1 9.8 5.5 4.6 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Ank_2 PF12796.7 EFA80701.1 - 7.1e-08 32.9 1.5 0.0092 16.6 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80701.1 - 2.3e-05 24.6 0.1 3.8 7.9 0.0 3.9 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80701.1 - 2.4e-05 24.8 4.2 1.8 9.2 0.0 5.1 2 2 5 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80701.1 - 7.8e-05 22.8 0.7 59 4.7 0.0 6.4 6 1 1 7 7 7 0 Ankyrin repeat DUF3447 PF11929.8 EFA80701.1 - 0.016 15.1 0.2 0.016 15.1 0.2 4.7 2 1 2 4 4 4 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA80702.1 - 5.7e-08 33.2 0.6 0.82 10.3 0.0 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80702.1 - 9.6e-06 26.1 5.6 4.5 8.0 0.0 5.7 4 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80702.1 - 0.00011 22.4 0.8 1.1e+02 3.9 0.0 7.0 6 1 1 7 7 7 0 Ankyrin repeat Ank_5 PF13857.6 EFA80702.1 - 0.00012 22.3 0.1 0.47 10.8 0.0 4.4 1 1 2 4 4 4 1 Ankyrin repeats (many copies) Glyco_transf_41 PF13844.6 EFA80704.1 - 3.3e-51 174.2 2.2 4e-28 98.1 0.4 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_1 PF00515.28 EFA80704.1 - 5.9e-14 51.2 5.9 4.2e-07 29.5 0.4 4.2 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA80704.1 - 1.2e-13 50.0 8.2 1.1e-05 25.1 0.1 5.3 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA80704.1 - 8.2e-13 47.8 10.8 2.7e-05 23.8 0.1 4.6 2 1 2 4 4 4 3 TPR repeat TPR_8 PF13181.6 EFA80704.1 - 2.3e-10 39.8 2.4 4.7e-05 23.3 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA80704.1 - 6.7e-07 29.3 8.5 0.00039 20.6 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA80704.1 - 1.8e-06 28.5 1.0 4.5e-05 24.0 0.1 3.1 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA80704.1 - 2.8e-06 27.5 0.6 0.00047 20.4 0.2 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA80704.1 - 5.2e-06 26.1 2.6 0.00093 19.1 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA80704.1 - 2.2e-05 24.9 2.3 0.016 15.7 1.5 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA80704.1 - 0.0013 19.4 0.9 0.72 10.8 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 EFA80704.1 - 0.0025 17.8 2.6 2.1 8.5 0.0 3.8 3 1 1 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 EFA80704.1 - 0.0063 17.1 0.1 2.2 9.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Cyclin_C_2 PF16899.5 EFA80704.1 - 0.027 14.8 0.2 2.2 8.7 0.0 3.0 3 0 0 3 3 2 0 Cyclin C-terminal domain DUF5494 PF17598.2 EFA80704.1 - 0.035 14.2 0.2 0.28 11.3 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5494) TPR_10 PF13374.6 EFA80704.1 - 0.062 13.2 2.8 0.38 10.7 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA80704.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 MalT-like TPR region SRAP PF02586.14 EFA80705.1 - 7.3e-47 159.7 0.9 3.4e-46 157.5 0.0 2.3 2 1 0 2 2 2 1 SOS response associated peptidase (SRAP) SpoIIIAH PF12685.7 EFA80705.1 - 1.3 8.8 24.0 0.87 9.4 0.5 2.5 2 0 0 2 2 2 0 SpoIIIAH-like protein TIG PF01833.24 EFA80706.1 - 2.4e-53 178.1 146.1 1.2e-08 34.9 3.4 17.9 13 2 5 18 18 18 14 IPT/TIG domain EGF_2 PF07974.13 EFA80706.1 - 0.00039 20.7 14.7 0.001 19.4 14.7 1.8 1 0 0 1 1 1 1 EGF-like domain Evf PF18270.1 EFA80706.1 - 0.029 13.8 0.4 3 7.2 0.1 2.4 2 0 0 2 2 2 0 Virulence factor Evf Peptidase_M23_N PF18421.1 EFA80706.1 - 0.03 14.2 0.0 0.99 9.3 0.0 3.2 2 0 0 2 2 2 0 Peptidase family M23 N-terminal domain EGF PF00008.27 EFA80706.1 - 0.078 13.3 9.5 0.25 11.7 9.5 1.9 1 0 0 1 1 1 0 EGF-like domain I-EGF_1 PF18372.1 EFA80706.1 - 0.44 10.7 8.5 1.1 9.5 8.5 1.6 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 hEGF PF12661.7 EFA80706.1 - 1.5 9.6 12.2 0.36 11.5 7.8 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFA80706.1 - 5.9 7.0 12.3 17 5.5 12.3 1.9 1 0 0 1 1 1 0 Tenascin EGF domain Myc_N PF01056.18 EFA80707.1 - 0.0038 17.2 2.8 0.0048 16.9 2.8 1.1 1 0 0 1 1 1 1 Myc amino-terminal region Treacle PF03546.14 EFA80707.1 - 0.17 10.7 3.8 0.21 10.4 3.8 1.1 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle PBP1_TM PF14812.6 EFA80707.1 - 0.26 11.7 3.9 0.6 10.5 3.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HEAT PF02985.22 EFA80709.1 - 1.1e-09 37.7 2.3 0.13 12.6 0.0 5.9 5 1 1 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EFA80709.1 - 0.0015 18.9 0.1 5.2 7.5 0.1 3.5 2 1 1 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EFA80709.1 - 0.012 16.1 0.0 4.8 7.9 0.0 3.3 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region PKcGMP_CC PF16808.5 EFA80709.1 - 1.8 8.4 8.7 4.1 7.3 5.5 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Striatin PF08232.12 EFA80709.1 - 3.2 8.3 36.7 0.1 13.2 11.9 3.3 3 0 0 3 3 3 0 Striatin family TANGO2 PF05742.12 EFA80710.1 - 2.2e-45 155.7 0.0 4.8e-45 154.6 0.0 1.5 1 0 0 1 1 1 1 Transport and Golgi organisation 2 EB PF01683.18 EFA80710.1 - 0.00014 22.1 3.2 0.00031 21.0 3.2 1.5 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 EFA80710.1 - 0.077 13.4 18.0 0.2 12.1 18.0 1.7 1 0 0 1 1 1 0 EGF-like domain I-EGF_1 PF18372.1 EFA80710.1 - 0.11 12.6 8.2 0.28 11.3 8.2 1.7 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 UPF0220 PF05255.11 EFA80711.1 - 0.0036 16.9 0.1 0.0038 16.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF1640 PF07798.11 EFA80712.1 - 0.028 14.5 2.9 0.044 13.8 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4715 PF15835.5 EFA80712.1 - 0.039 14.0 0.4 0.07 13.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) DNA_pol_phi PF04931.13 EFA80712.1 - 0.15 10.2 12.3 0.017 13.2 5.7 2.0 2 0 0 2 2 2 0 DNA polymerase phi Importin_rep_6 PF18829.1 EFA80712.1 - 0.19 11.9 5.0 0.11 12.6 1.5 2.1 2 0 0 2 2 2 0 Importin repeat 6 PBP1_TM PF14812.6 EFA80712.1 - 0.66 10.4 9.4 1.6 9.2 9.4 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EFA80712.1 - 0.99 9.8 16.6 2.5 8.5 16.6 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CENP-Q PF13094.6 EFA80712.1 - 3.6 7.8 15.2 4.1 7.6 5.7 2.8 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit NOA36 PF06524.12 EFA80712.1 - 6.5 6.0 16.7 12 5.1 16.7 1.4 1 0 0 1 1 1 0 NOA36 protein YabA PF06156.13 EFA80712.1 - 7.4 7.3 7.7 0.96 10.1 2.7 2.1 2 0 0 2 2 2 0 Initiation control protein YabA RhoGAP PF00620.27 EFA80713.1 - 3e-07 30.4 0.2 6.3e-07 29.3 0.2 1.6 1 1 1 2 2 2 1 RhoGAP domain Serglycin PF04360.12 EFA80713.1 - 0.0013 18.7 2.1 0.0018 18.2 2.1 1.3 1 0 0 1 1 1 1 Serglycin Neuralized PF07177.12 EFA80716.1 - 0.038 14.0 0.0 0.042 13.9 0.0 1.0 1 0 0 1 1 1 0 Neuralized FAST_1 PF06743.15 EFA80721.1 - 0.097 12.6 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 Ank_2 PF12796.7 EFA80723.1 - 8.6e-21 74.3 1.8 5.5e-06 26.9 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80723.1 - 5.6e-14 52.3 7.7 0.0034 17.9 0.3 6.7 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA80723.1 - 7.9e-14 51.5 7.6 0.94 9.9 0.0 8.3 5 4 4 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80723.1 - 1.7e-11 43.3 5.8 0.33 11.6 0.0 8.8 11 0 0 11 11 11 2 Ankyrin repeat DUF3447 PF11929.8 EFA80723.1 - 6.7e-05 22.8 13.6 0.72 9.9 0.3 6.1 3 3 3 6 6 6 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA80723.1 - 9.3e-05 22.7 0.4 9.3 6.9 0.0 5.2 6 1 0 6 6 6 1 Ankyrin repeat DUF249 PF03158.13 EFA80723.1 - 0.0077 16.0 1.1 0.0077 16.0 1.1 3.8 3 1 1 4 4 4 1 Multigene family 530 protein Ank_5 PF13857.6 EFA80724.1 - 7.5e-07 29.3 0.2 0.26 11.6 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80724.1 - 9.1e-07 29.3 0.4 0.06 14.0 0.4 3.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80724.1 - 2.3e-06 28.1 0.1 0.0042 17.6 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80724.1 - 5e-06 26.4 0.2 0.13 12.9 0.0 4.1 5 0 0 5 5 5 2 Ankyrin repeat GDP_Man_Dehyd PF16363.5 EFA80727.1 - 2.9e-52 178.1 0.0 4.5e-52 177.5 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA80727.1 - 1.2e-50 172.3 0.1 1.4e-50 172.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA80727.1 - 1.2e-15 57.3 0.1 3.2e-15 55.9 0.3 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFA80727.1 - 5.2e-13 48.8 0.1 4.3e-12 45.8 0.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFA80727.1 - 2.2e-09 36.8 0.0 3.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EFA80727.1 - 9.7e-07 28.9 0.0 1.6e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EFA80727.1 - 3.9e-06 26.2 0.5 0.00032 19.9 0.5 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EFA80727.1 - 7.6e-05 22.7 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFA80727.1 - 0.00017 21.1 0.1 0.00029 20.4 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 EFA80727.1 - 0.026 14.8 0.1 0.046 14.0 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EFA80727.1 - 0.069 12.7 0.2 1.7 8.1 0.3 2.3 2 1 0 2 2 2 0 NmrA-like family Mss4 PF04421.13 EFA80728.1 - 2.7e-17 62.7 0.2 2.7e-17 62.7 0.2 2.2 1 1 1 2 2 2 1 Mss4 protein Spt20 PF12090.8 EFA80728.1 - 0.0016 18.1 3.1 0.002 17.8 3.1 1.1 1 0 0 1 1 1 1 Spt20 family Yippee-Mis18 PF03226.14 EFA80728.1 - 0.035 14.3 5.7 0.079 13.2 4.0 2.1 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Dak1_2 PF13684.6 EFA80728.1 - 0.054 12.6 2.3 0.071 12.2 2.3 1.1 1 0 0 1 1 1 0 Dihydroxyacetone kinase family V-ATPase_G PF03179.15 EFA80729.1 - 5.7e-28 97.5 14.1 6.6e-28 97.3 14.1 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF2353 PF09789.9 EFA80729.1 - 0.0022 17.4 8.9 0.0022 17.4 8.9 1.0 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Apolipoprotein PF01442.18 EFA80729.1 - 0.0047 16.8 1.9 0.0047 16.8 1.9 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain ATP-synt_B PF00430.18 EFA80729.1 - 0.018 15.1 10.5 0.018 15.1 10.5 1.9 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF3584 PF12128.8 EFA80729.1 - 0.04 11.4 10.4 0.045 11.3 10.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) V-ATPase_G_2 PF16999.5 EFA80729.1 - 0.053 14.0 10.2 0.07 13.6 10.2 1.1 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit UPF0242 PF06785.11 EFA80729.1 - 0.065 13.3 10.8 0.079 13.1 10.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4570 PF15134.6 EFA80729.1 - 0.1 12.6 5.2 0.053 13.5 2.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) DUF3552 PF12072.8 EFA80729.1 - 0.18 11.2 15.7 0.52 9.7 15.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) PCRF PF03462.18 EFA80729.1 - 0.36 10.7 8.4 0.45 10.3 8.4 1.1 1 0 0 1 1 1 0 PCRF domain AcylCoA_dehyd_C PF12186.8 EFA80729.1 - 0.73 10.0 6.4 0.29 11.3 2.6 1.9 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase C terminal DUF2570 PF10828.8 EFA80729.1 - 0.93 9.3 8.5 1.1 9.1 6.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) AAA_11 PF13086.6 EFA80729.1 - 0.94 9.2 8.3 1.1 8.9 8.3 1.2 1 0 0 1 1 1 0 AAA domain Prominin PF05478.11 EFA80729.1 - 0.99 7.3 5.9 0.98 7.3 5.9 1.0 1 0 0 1 1 1 0 Prominin CDRT4 PF15213.6 EFA80729.1 - 1.3 9.6 4.8 2.4 8.7 4.7 1.4 1 1 0 1 1 1 0 CMT1A duplicated region transcript 4 protein Histidinol_dh PF00815.20 EFA80729.1 - 3.4 6.6 8.1 0.82 8.6 3.6 1.8 1 1 1 2 2 2 0 Histidinol dehydrogenase LMBR1 PF04791.16 EFA80729.1 - 5 5.9 7.3 6.1 5.6 6.6 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein Ribosomal_L14e PF01929.17 EFA80731.1 - 4.7e-19 68.7 1.8 4.7e-19 68.7 1.8 1.6 2 0 0 2 2 2 1 Ribosomal protein L14 DUF262 PF03235.14 EFA80731.1 - 0.021 15.0 1.9 0.03 14.5 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 KOW PF00467.29 EFA80731.1 - 0.025 14.5 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 KOW motif EGF_2 PF07974.13 EFA80732.1 - 0.00032 21.0 8.0 0.00032 21.0 8.0 2.4 2 0 0 2 2 2 1 EGF-like domain EGF_Tenascin PF18720.1 EFA80732.1 - 0.0062 16.6 7.4 0.02 15.0 7.4 1.9 1 0 0 1 1 1 1 Tenascin EGF domain Big_3_2 PF12245.8 EFA80732.1 - 0.088 13.1 1.1 3 8.1 0.0 2.9 2 0 0 2 2 2 0 Bacterial Ig-like domain I-EGF_1 PF18372.1 EFA80732.1 - 0.91 9.7 10.0 1 9.5 6.2 2.5 2 0 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 TIG PF01833.24 EFA80733.1 - 1.3e-63 211.1 91.2 1.2e-10 41.4 0.8 12.9 12 1 0 12 12 12 11 IPT/TIG domain DNase_II PF03265.15 EFA80733.1 - 4.6e-31 108.3 7.1 1.2e-30 106.9 1.2 3.0 2 1 0 2 2 2 1 Deoxyribonuclease II AAA_lid_11 PF18198.1 EFA80733.1 - 0.042 13.7 0.4 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 Dynein heavy chain AAA lid domain DASH_Duo1 PF08651.10 EFA80733.1 - 0.13 12.1 2.9 0.38 10.6 2.9 1.8 1 0 0 1 1 1 0 DASH complex subunit Duo1 FNIP PF05725.12 EFA80734.1 - 2.1e-30 104.6 35.3 2.8e-10 40.2 0.2 8.0 5 2 2 7 7 7 7 FNIP Repeat LRR_4 PF12799.7 EFA80734.1 - 0.088 13.3 17.9 12 6.5 0.8 6.7 3 2 4 7 7 7 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 EFA80735.1 - 2e-29 101.5 28.9 2.5e-09 37.2 0.2 6.8 6 0 0 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA80735.1 - 5.2e-05 22.7 0.1 0.0001 21.8 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80735.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.2 2 0 0 2 2 2 0 F-box-like ABC2_membrane PF01061.24 EFA80736.1 - 2.8e-80 268.7 55.1 1e-45 155.7 22.2 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EFA80736.1 - 1.1e-36 126.4 0.0 2.8e-18 66.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFA80736.1 - 7.8e-30 102.6 1.7 8.1e-22 76.9 0.1 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EFA80736.1 - 2.7e-09 37.5 0.1 6.1e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EFA80736.1 - 1.1e-07 31.4 25.9 1.1e-07 31.4 25.9 3.2 3 1 0 3 3 3 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFA80736.1 - 2.3e-07 30.9 0.1 0.00022 21.2 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EFA80736.1 - 2.6e-05 24.2 0.0 0.11 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA80736.1 - 5.2e-05 22.9 0.5 0.0068 16.1 0.2 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA80736.1 - 0.00027 21.3 0.0 0.03 14.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFA80736.1 - 0.00071 19.9 0.0 0.29 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA80736.1 - 0.0066 17.0 0.0 1.1 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFA80736.1 - 0.012 15.7 0.0 5.3 7.1 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_25 PF13481.6 EFA80736.1 - 0.013 15.1 0.1 0.052 13.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFA80736.1 - 0.016 14.5 0.0 3.9 6.7 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 EFA80736.1 - 0.016 14.9 0.0 1.9 8.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFA80736.1 - 0.019 14.5 0.1 0.37 10.4 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 EFA80736.1 - 0.025 14.5 0.0 2.9 7.8 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA PF00004.29 EFA80736.1 - 0.1 13.0 0.1 6.8 7.1 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFA80736.1 - 0.11 12.6 0.0 0.89 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFA80736.1 - 0.14 11.9 0.0 0.44 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFA80736.1 - 0.17 11.6 0.0 7.6 6.2 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.6 EFA80736.1 - 0.93 9.7 2.6 0.86 9.8 0.3 2.2 3 0 0 3 3 2 0 AAA domain S1 PF00575.23 EFA80737.1 - 1.3e-13 51.1 10.5 0.00015 22.0 0.0 6.8 7 1 0 7 7 7 3 S1 RNA binding domain Tim17 PF02466.19 EFA80738.1 - 3.3e-06 27.4 1.3 6.5e-06 26.5 0.7 1.7 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF5320 PF17253.2 EFA80738.1 - 3 9.0 4.1 2.3 9.3 1.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Gly-zipper_YMGG PF13441.6 EFA80738.1 - 3 7.7 5.1 5.6 6.8 1.0 2.3 2 0 0 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 EFA80738.1 - 5.3 7.1 8.2 2.1 8.4 2.4 2.3 2 0 0 2 2 2 0 Glycine zipper Cellulase PF00150.18 EFA80739.1 - 4.3e-31 108.4 3.6 6.3e-31 107.8 3.6 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_53 PF07745.13 EFA80739.1 - 0.0011 18.0 0.1 0.0022 17.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 DDHD PF02862.17 EFA80739.1 - 0.085 13.0 1.0 0.14 12.3 1.0 1.3 1 0 0 1 1 1 0 DDHD domain Peptidase_S49_N PF08496.10 EFA80739.1 - 0.4 10.7 3.9 0.81 9.7 3.9 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ALMT PF11744.8 EFA80739.1 - 2.9 6.6 4.5 4 6.2 4.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RNA_pol_Rpc4 PF05132.14 EFA80739.1 - 3.5 8.0 6.3 5.5 7.4 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 EFA80739.1 - 7.2 5.7 6.4 10 5.2 6.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CLU PF13236.6 EFA80740.1 - 4.6e-55 186.8 0.0 1.4e-54 185.3 0.0 1.9 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA80740.1 - 0.0012 19.0 0.1 0.0012 19.0 0.1 2.4 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 Strep_pep PF14404.6 EFA80742.1 - 0.36 11.1 2.2 35 4.8 0.0 3.5 4 0 0 4 4 4 0 Ribosomally synthesized peptide in Streptomyces species FNIP PF05725.12 EFA80743.1 - 1.5e-20 73.1 31.6 9.3e-07 28.9 0.0 9.4 10 1 0 10 10 10 4 FNIP Repeat F-box_5 PF18511.1 EFA80743.1 - 0.00027 20.4 0.1 0.00059 19.3 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80743.1 - 0.024 14.5 0.2 0.064 13.2 0.2 1.8 1 0 0 1 1 1 0 F-box-like FerA PF08165.11 EFA80743.1 - 0.053 13.5 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 FerA (NUC095) domain BRCT_2 PF16589.5 EFA80744.1 - 6e-08 33.0 1.1 3.5e-07 30.5 0.1 2.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA80744.1 - 1.1e-07 32.1 0.2 1.1e-07 32.1 0.2 2.7 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain RRM_1 PF00076.22 EFA80744.1 - 0.0043 16.8 0.2 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA80744.1 - 0.027 14.5 0.2 0.052 13.6 0.2 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Y_Y_Y PF07495.13 EFA80745.1 - 3.6e-05 23.6 1.3 0.091 12.7 0.1 2.9 2 0 0 2 2 2 2 Y_Y_Y domain SpaA PF17802.1 EFA80745.1 - 0.19 12.1 3.2 0.41 11.0 0.1 2.7 2 1 0 2 2 2 0 Prealbumin-like fold domain DUF4397 PF14344.6 EFA80745.1 - 3.9 8.3 6.7 5.3 7.9 0.0 3.6 3 2 1 4 4 4 0 Domain of unknown function (DUF4397) Big_3_5 PF16640.5 EFA80745.1 - 3.9 7.7 20.0 0.11 12.7 0.5 4.3 2 1 1 4 4 4 0 Bacterial Ig-like domain (group 3) Cpn60_TCP1 PF00118.24 EFA80747.1 - 4.3e-151 503.9 15.8 4.8e-151 503.7 15.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PS_pyruv_trans PF04230.13 EFA80748.1 - 0.053 13.4 0.1 0.065 13.2 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase ETRAMP PF09716.10 EFA80749.1 - 0.13 12.3 1.5 3.4 7.8 0.0 2.9 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TIG PF01833.24 EFA80749.1 - 0.33 11.1 8.4 0.42 10.7 0.0 3.2 3 1 0 3 3 3 0 IPT/TIG domain DUF2098 PF09871.9 EFA80749.1 - 0.64 10.4 7.3 8.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) Atrophin-1 PF03154.15 EFA80749.1 - 4.7 5.4 14.2 6.6 4.9 14.2 1.1 1 0 0 1 1 1 0 Atrophin-1 family 2OG-FeII_Oxy_3 PF13640.6 EFA80750.1 - 2.5e-15 57.1 0.0 4.2e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFA80750.1 - 0.00012 22.5 0.0 0.0002 21.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFA80750.1 - 0.019 14.1 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Poxvirus C4/C10 protein DUF2652 PF10851.8 EFA80750.1 - 0.13 12.4 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2652) NMO PF03060.15 EFA80751.1 - 9.7e-33 113.9 0.0 4.1e-23 82.3 0.0 2.4 1 1 1 2 2 2 2 Nitronate monooxygenase FNIP PF05725.12 EFA80751.1 - 5.9e-15 55.2 0.4 1.8e-07 31.2 0.0 5.0 4 2 1 5 5 5 3 FNIP Repeat DHO_dh PF01180.21 EFA80751.1 - 8.2e-06 25.2 0.0 1.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase F-box_5 PF18511.1 EFA80751.1 - 0.00013 21.5 0.3 0.00026 20.5 0.3 1.5 1 0 0 1 1 1 1 F-box His_biosynth PF00977.21 EFA80751.1 - 0.00027 20.5 0.0 0.00088 18.8 0.0 1.8 2 0 0 2 2 2 1 Histidine biosynthesis protein F-box-like PF12937.7 EFA80751.1 - 0.0011 18.8 0.6 0.003 17.4 0.6 1.8 1 0 0 1 1 1 1 F-box-like IMPDH PF00478.25 EFA80751.1 - 0.0022 17.0 0.1 0.0048 16.0 0.1 1.5 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain F-box PF00646.33 EFA80751.1 - 0.004 17.0 0.8 0.011 15.6 0.8 1.7 1 0 0 1 1 1 1 F-box domain G3P_antiterm PF04309.12 EFA80751.1 - 0.029 13.8 0.0 0.067 12.6 0.0 1.5 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator FMN_dh PF01070.18 EFA80751.1 - 0.18 10.8 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase UTP15_C PF09384.10 EFA80752.1 - 2.3e-30 105.2 0.5 4.3e-30 104.3 0.5 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EFA80752.1 - 1.2e-19 70.3 6.5 1.1e-05 26.1 0.9 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40_like PF17005.5 EFA80752.1 - 1.4e-06 27.9 0.4 0.023 14.0 0.0 2.3 1 1 1 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 EFA80752.1 - 2e-06 28.0 0.5 0.97 9.8 0.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nop14 PF04147.12 EFA80752.1 - 0.021 13.1 24.3 0.031 12.5 24.3 1.3 1 0 0 1 1 1 0 Nop14-like family Dapper PF15268.6 EFA80752.1 - 0.027 13.4 22.1 0.035 13.0 22.1 1.2 1 0 0 1 1 1 0 Dapper AF-4 PF05110.13 EFA80752.1 - 0.12 10.4 30.3 0.16 10.0 30.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Trypan_PARP PF05887.11 EFA80752.1 - 0.23 11.5 11.4 0.39 10.7 11.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ThiC-associated PF13667.6 EFA80752.1 - 0.35 10.7 5.8 2.9 7.8 0.1 2.8 2 0 0 2 2 2 0 ThiC-associated domain CobT PF06213.12 EFA80752.1 - 1 8.7 16.4 0.62 9.4 13.8 1.9 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 EFA80752.1 - 5.4 5.7 22.9 8 5.1 22.9 1.2 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 EFA80752.1 - 6.2 6.0 14.4 14 4.9 14.4 1.5 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EFA80752.1 - 7.4 4.7 21.8 11 4.1 21.8 1.2 1 0 0 1 1 1 0 CDC45-like protein VGLL4 PF15245.6 EFA80753.1 - 0.057 13.5 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 Ank_2 PF12796.7 EFA80755.1 - 1.6e-10 41.4 0.1 1.4e-05 25.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80755.1 - 0.0011 19.2 0.1 1.5 9.2 0.0 3.5 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80755.1 - 0.0011 19.2 0.1 7.1 7.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFA80755.1 - 0.019 15.5 0.1 4.6 7.9 0.0 2.8 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Macoilin PF09726.9 EFA80755.1 - 2.2 6.7 6.5 2.6 6.5 6.5 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 EFA80755.1 - 2.9 6.1 12.4 3.7 5.7 12.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MAP70 PF07058.11 EFA80755.1 - 3.6 6.2 3.8 4.6 5.9 3.8 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Ank_2 PF12796.7 EFA80756.1 - 2.4e-10 40.9 2.7 0.0026 18.3 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80756.1 - 3.8e-07 29.9 2.0 0.78 10.5 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFA80756.1 - 1.4e-06 28.8 2.8 0.031 14.9 0.1 4.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA80756.1 - 0.00053 20.2 0.1 4.5 7.7 0.0 4.8 4 2 1 6 6 6 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA80756.1 - 0.14 12.6 2.5 37 5.0 0.0 4.3 5 0 0 5 5 5 0 Ankyrin repeat GST_N_2 PF13409.6 EFA80757.1 - 4.1e-13 49.4 0.0 8.9e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFA80757.1 - 4.6e-13 49.3 0.0 9.9e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFA80757.1 - 2.9e-12 46.8 0.0 6e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA80757.1 - 1e-11 44.8 0.0 2.3e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA80757.1 - 3.4e-10 40.0 0.1 6.9e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA80757.1 - 4.9e-07 29.7 0.1 1e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA80757.1 - 0.024 14.4 0.1 0.046 13.5 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EFA80757.1 - 0.056 13.7 0.0 0.25 11.6 0.0 2.0 2 0 0 2 2 2 0 Glutaredoxin FNIP PF05725.12 EFA80758.1 - 2e-48 162.3 47.1 2.6e-06 27.5 0.4 15.2 14 3 3 17 17 17 10 FNIP Repeat F-box_5 PF18511.1 EFA80758.1 - 2e-09 36.9 0.3 0.00015 21.3 0.0 2.5 2 0 0 2 2 2 2 F-box F-box-like PF12937.7 EFA80758.1 - 9.1e-06 25.5 3.4 0.04 13.8 0.2 3.3 3 0 0 3 3 3 2 F-box-like FerA PF08165.11 EFA80758.1 - 0.099 12.6 2.6 0.96 9.4 0.1 3.1 3 0 0 3 3 3 0 FerA (NUC095) domain F-box PF00646.33 EFA80758.1 - 0.84 9.6 3.5 11 6.0 0.2 3.4 3 0 0 3 3 3 0 F-box domain Pex19 PF04614.12 EFA80759.1 - 0.0011 18.8 0.7 0.0023 17.8 0.7 1.5 1 0 0 1 1 1 1 Pex19 protein family TFCD_C PF12612.8 EFA80759.1 - 0.08 12.8 0.1 0.54 10.1 0.0 2.1 2 1 0 2 2 2 0 Tubulin folding cofactor D C terminal FNIP PF05725.12 EFA80759.1 - 6.7 7.0 9.9 0.97 9.7 5.5 1.9 2 0 0 2 2 2 0 FNIP Repeat ubiquitin PF00240.23 EFA80760.1 - 4.9e-14 51.8 0.0 1.2e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA80760.1 - 4.5e-06 26.4 0.1 1.3e-05 24.9 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFA80760.1 - 0.00076 19.6 2.2 0.0011 19.0 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like TCP PF03634.13 EFA80760.1 - 0.0023 18.5 2.3 0.0023 18.5 2.3 3.2 3 1 0 3 3 3 1 TCP family transcription factor Ubiquitin_2 PF14560.6 EFA80760.1 - 0.0048 17.3 0.5 0.016 15.6 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-like domain Sec20 PF03908.13 EFA80760.1 - 0.081 12.9 1.3 0.24 11.3 1.3 1.9 1 0 0 1 1 1 0 Sec20 DUF2407 PF10302.9 EFA80760.1 - 0.11 13.1 0.1 0.11 13.1 0.1 3.4 3 2 1 4 4 4 0 DUF2407 ubiquitin-like domain Tim44 PF04280.15 EFA80761.1 - 1.2e-07 32.0 0.0 3.3e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Tim44-like domain eIF-3_zeta PF05091.12 EFA80761.1 - 0.12 11.3 9.8 0.17 10.8 9.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 EFA80761.1 - 0.15 11.7 19.7 0.28 10.7 19.7 1.5 1 0 0 1 1 1 0 Spt20 family DUF4175 PF13779.6 EFA80761.1 - 0.59 8.0 22.2 0.8 7.5 22.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF908 PF06012.12 EFA80761.1 - 2.8 7.2 8.4 4.4 6.6 8.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Neur_chan_memb PF02932.16 EFA80761.1 - 5.8 6.9 5.8 9.4 6.2 5.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EFA80761.1 - 8.9 5.0 11.5 12 4.5 11.5 1.1 1 0 0 1 1 1 0 Presenilin Histone_H2A_C PF16211.5 EFA80762.1 - 2.4e-13 49.5 2.1 2.4e-13 49.5 2.1 2.2 2 1 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 EFA80762.1 - 1.8e-07 31.5 0.3 2.8e-07 31.0 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFA80762.1 - 0.012 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Thiolase_N PF00108.23 EFA80763.1 - 3.5e-90 301.9 1.1 1.5e-89 299.8 0.6 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFA80763.1 - 5.2e-45 152.1 0.7 1.1e-44 151.0 0.7 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFA80763.1 - 0.0014 18.2 0.8 0.0051 16.4 0.5 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PseudoU_synth_1 PF01416.20 EFA80764.1 - 2.2e-11 44.2 0.0 3.9e-08 33.7 0.0 3.1 2 1 0 2 2 2 2 tRNA pseudouridine synthase MRP-S33 PF08293.11 EFA80764.1 - 0.12 12.7 7.5 0.093 13.0 2.9 3.0 3 0 0 3 3 3 0 Mitochondrial ribosomal subunit S27 Pox_Ag35 PF03286.14 EFA80764.1 - 0.65 9.8 19.9 0.035 13.9 9.5 2.9 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Myc_N PF01056.18 EFA80764.1 - 1.4 8.7 11.5 0.058 13.3 5.0 1.9 2 0 0 2 2 2 0 Myc amino-terminal region DUF4746 PF15928.5 EFA80764.1 - 9.4 5.6 17.7 1.7 8.0 7.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) tRNA-synt_2d PF01409.20 EFA80765.1 - 3.9e-83 278.7 0.0 5.3e-83 278.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EFA80765.1 - 2.5e-09 37.3 0.2 5e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EFA80765.1 - 6.6e-06 25.7 0.0 0.0021 17.5 0.0 2.4 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD1 PF18552.1 EFA80765.1 - 2.2e-05 24.1 0.0 7e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 1 tRNA-synt_2 PF00152.20 EFA80765.1 - 8.2e-05 21.8 0.1 0.00047 19.3 0.0 2.2 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) Endosulfine PF04667.17 EFA80766.1 - 5.2e-07 29.7 0.0 7e-07 29.3 0.0 1.3 1 1 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region GMC_oxred_N PF00732.19 EFA80768.1 - 2.3e-17 63.3 0.3 3.1e-09 36.7 0.0 2.7 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA80768.1 - 2.7e-15 57.1 0.0 5.4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EFA80768.1 - 0.018 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 EFA80768.1 - 0.027 13.7 0.0 0.052 12.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 EFA80768.1 - 0.034 14.4 0.1 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFA80768.1 - 0.064 12.5 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA80768.1 - 0.074 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 EFA80768.1 - 0.084 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EFA80768.1 - 0.11 11.3 0.2 0.74 8.6 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase TrkA_N PF02254.18 EFA80768.1 - 0.17 12.2 0.1 0.34 11.2 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain COMM_domain PF07258.14 EFA80769.1 - 9.4e-14 51.3 4.8 2e-13 50.3 4.8 1.5 1 0 0 1 1 1 1 COMM domain COMMD1_N PF17221.3 EFA80769.1 - 4.3e-13 49.4 4.5 7.9e-13 48.6 0.9 2.3 2 0 0 2 2 2 1 COMMD1 N-terminal domain SQS_PSY PF00494.19 EFA80770.1 - 7.9e-36 123.9 0.0 1e-35 123.5 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Ank_5 PF13857.6 EFA80772.1 - 1.4e-34 117.7 16.0 0.0036 17.6 0.0 13.4 4 2 9 13 13 13 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80772.1 - 2e-33 114.3 17.8 1.5e-05 25.5 0.1 10.7 5 4 6 11 11 11 10 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80772.1 - 1.4e-29 102.5 11.0 1.3e-09 38.5 0.0 7.4 3 3 6 9 9 9 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80772.1 - 4.3e-16 57.4 5.1 3.3 8.6 0.0 14.1 13 1 2 15 15 15 1 Ankyrin repeat DUF5049 PF16468.5 EFA80772.1 - 6.6e-07 29.1 0.0 70 3.4 0.0 8.3 7 2 2 9 9 9 0 Domain of unknown function (DUF5049) DUF3322 PF11795.8 EFA80772.1 - 0.0017 18.4 0.5 23 4.9 0.0 5.4 8 1 0 8 8 8 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Ank PF00023.30 EFA80772.1 - 0.04 14.4 1.7 8.7 7.0 0.0 5.4 5 2 1 6 6 4 0 Ankyrin repeat SDA1 PF05285.12 EFA80772.1 - 0.084 12.3 4.4 0.15 11.5 4.4 1.3 1 0 0 1 1 1 0 SDA1 PBP1_TM PF14812.6 EFA80772.1 - 0.43 11.0 8.2 1 9.8 8.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 EFA80772.1 - 0.76 9.8 5.0 1.7 8.6 3.8 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal RNA_pol_3_Rpc31 PF11705.8 EFA80772.1 - 0.84 9.9 9.8 1.5 9.0 9.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Methyltransf_22 PF13383.6 EFA80773.1 - 2.1e-12 47.2 2.1 2.1e-12 47.2 2.1 1.6 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_21 PF05050.12 EFA80773.1 - 2.8e-12 47.0 0.7 6.3e-12 45.9 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase FkbM domain PQQ PF01011.21 EFA80774.1 - 7.2e-05 22.5 0.1 0.0043 16.9 0.0 3.3 3 0 0 3 3 3 1 PQQ enzyme repeat ANAPC4_WD40 PF12894.7 EFA80774.1 - 0.0005 20.3 0.0 0.089 13.1 0.0 3.0 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA80774.1 - 0.0019 19.0 0.7 0.12 13.3 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EFA80774.1 - 0.0063 15.8 0.8 0.019 14.2 0.2 2.0 1 1 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus CBM_19 PF03427.13 EFA80774.1 - 0.018 15.0 0.6 0.048 13.6 0.6 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) PQQ_2 PF13360.6 EFA80774.1 - 0.047 13.3 0.1 0.082 12.5 0.1 1.3 1 0 0 1 1 1 0 PQQ-like domain F-box PF00646.33 EFA80774.1 - 0.06 13.2 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 F-box domain Exop_C PF18559.1 EFA80775.1 - 0.023 14.5 0.8 0.023 14.5 0.8 1.0 1 0 0 1 1 1 0 Galactose-binding domain-like RRM_1 PF00076.22 EFA80777.1 - 5e-21 74.3 0.2 9.4e-21 73.4 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA80777.1 - 0.00065 19.3 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EFA80779.1 - 2.8e-54 184.2 0.0 4.7e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80779.1 - 3.2e-39 134.8 0.0 4.9e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA80779.1 - 0.0078 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like 14-3-3 PF00244.20 EFA80780.1 - 1.5e-71 240.4 3.0 2.2e-71 239.9 3.0 1.2 1 0 0 1 1 1 1 14-3-3 protein Katanin_con80 PF13925.6 EFA80780.1 - 0.012 15.6 1.3 1.7 8.6 0.1 2.5 2 0 0 2 2 2 0 con80 domain of Katanin Coatomer_g_Cpla PF16381.5 EFA80780.1 - 0.019 15.1 0.0 0.59 10.3 0.0 2.5 2 0 0 2 2 2 0 Coatomer subunit gamma-1 C-terminal appendage platform Methyltransf_21 PF05050.12 EFA80781.1 - 2.7e-10 40.5 0.3 1.9e-08 34.5 0.1 2.6 2 1 0 2 2 2 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.6 EFA80781.1 - 2.1e-08 34.0 13.0 0.00098 18.8 1.3 3.3 2 2 1 3 3 3 3 Methyltransferase domain DUF4446 PF14584.6 EFA80781.1 - 0.018 15.0 2.9 0.018 15.0 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Telomerase_RBD PF12009.8 EFA80781.1 - 0.03 14.4 1.5 0.23 11.6 0.5 2.5 2 1 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain Snapin_Pallidin PF14712.6 EFA80781.1 - 0.056 13.9 7.0 0.43 11.0 1.3 2.8 2 1 0 2 2 2 0 Snapin/Pallidin DUF3278 PF11683.8 EFA80781.1 - 0.075 13.1 3.2 0.08 13.0 1.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) ArfA PF03889.13 EFA80781.1 - 0.076 12.5 0.1 0.21 11.1 0.1 1.7 1 0 0 1 1 1 0 Alternative ribosome-rescue factor A LPD14 PF18827.1 EFA80781.1 - 0.076 13.3 0.3 0.18 12.1 0.3 1.7 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 14 Ax_dynein_light PF10211.9 EFA80781.1 - 0.1 12.5 5.7 0.15 12.0 0.5 2.3 2 0 0 2 2 2 0 Axonemal dynein light chain DUF5601 PF18151.1 EFA80781.1 - 0.14 12.5 1.8 3.3 8.1 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) FlaC_arch PF05377.11 EFA80781.1 - 1.5 9.3 8.0 0.54 10.7 2.5 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FlxA PF14282.6 EFA80781.1 - 4.7 7.3 11.0 2.4 8.2 5.0 2.3 2 0 0 2 2 2 0 FlxA-like protein DHR-2 PF06920.13 EFA80783.1 - 1.3e-46 159.4 13.5 5.1e-46 157.4 13.5 1.9 1 1 0 1 1 1 1 Dock homology region 2 F-box-like PF12937.7 EFA80783.1 - 1.2e-07 31.5 0.2 2.6e-07 30.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA80783.1 - 0.005 16.7 0.0 0.016 15.0 0.0 1.9 1 0 0 1 1 1 1 F-box domain NARP1 PF12569.8 EFA80784.1 - 1e-126 423.9 36.6 2.9e-116 389.4 22.0 3.7 2 2 1 4 4 4 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EFA80784.1 - 2.5e-13 49.0 37.0 3.4e-05 23.6 0.1 9.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFA80784.1 - 2.2e-12 47.3 13.5 0.011 16.2 0.7 6.6 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFA80784.1 - 9.2e-12 44.7 4.1 1.1 10.2 0.0 8.8 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA80784.1 - 3.6e-06 27.5 13.3 0.099 13.3 0.2 7.0 9 0 0 9 9 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA80784.1 - 5.7e-06 25.9 31.1 0.0015 18.2 0.0 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA80784.1 - 6.8e-06 25.9 24.6 0.15 12.3 0.6 7.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFA80784.1 - 5.1e-05 23.4 11.3 0.00051 20.2 0.0 5.9 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA80784.1 - 0.00087 19.8 18.1 4.1 8.3 0.0 9.7 12 0 0 12 12 10 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFA80784.1 - 0.0026 17.9 0.1 0.3 11.2 0.1 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA80784.1 - 0.0029 17.8 24.3 0.035 14.4 0.0 7.2 8 2 2 10 10 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA80784.1 - 0.0052 17.0 32.7 0.083 13.1 1.5 7.3 6 2 2 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFA80784.1 - 0.008 16.1 7.4 17 5.7 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA80784.1 - 0.02 14.3 1.0 1.6 8.0 0.0 3.1 3 0 0 3 3 3 0 MalT-like TPR region TPR_11 PF13414.6 EFA80784.1 - 0.22 11.2 11.6 13 5.5 0.0 6.1 5 1 1 6 6 6 0 TPR repeat TPR_10 PF13374.6 EFA80784.1 - 1.2 9.1 11.1 11 6.1 0.0 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA80784.1 - 7 6.8 18.2 0.14 12.2 0.6 5.7 8 0 0 8 8 7 0 Fis1 C-terminal tetratricopeptide repeat PIF1 PF05970.14 EFA80785.1 - 2.1e-29 102.8 0.5 2.1e-29 102.8 0.5 2.5 2 1 1 3 3 3 1 PIF1-like helicase AAA_30 PF13604.6 EFA80785.1 - 1.3e-15 57.6 0.1 1.3e-15 57.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFA80785.1 - 1.8e-11 44.6 0.3 1.8e-11 44.6 0.3 2.3 3 1 0 3 3 3 1 AAA domain T2SSE PF00437.20 EFA80785.1 - 4.2e-06 26.0 3.4 4.2e-06 26.0 3.4 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 EFA80785.1 - 7.1e-06 25.6 0.2 5.4e-05 22.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFA80785.1 - 4e-05 23.9 1.9 6.6e-05 23.2 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFA80785.1 - 4.2e-05 23.6 0.1 0.00042 20.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Helicase_RecD PF05127.14 EFA80785.1 - 7.5e-05 22.7 0.2 7.5e-05 22.7 0.2 3.2 3 1 0 3 3 3 1 Helicase ATPase_2 PF01637.18 EFA80785.1 - 0.00062 19.8 0.3 0.00062 19.8 0.3 2.7 1 1 1 3 3 3 1 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EFA80785.1 - 0.00077 19.4 0.1 1.8 8.5 0.0 2.6 2 0 0 2 2 2 2 NTPase NACHT PF05729.12 EFA80785.1 - 0.005 16.8 0.3 0.018 14.9 0.0 2.1 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 EFA80785.1 - 0.0062 15.9 0.1 0.015 14.7 0.1 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EFA80785.1 - 0.0069 16.8 0.1 0.0069 16.8 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 EFA80785.1 - 0.014 15.1 0.7 0.032 14.0 0.2 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain UvrD_C_2 PF13538.6 EFA80785.1 - 0.025 14.4 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain IstB_IS21 PF01695.17 EFA80785.1 - 0.061 13.1 0.1 0.061 13.1 0.1 2.6 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA PF00004.29 EFA80785.1 - 0.07 13.5 0.1 0.07 13.5 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFA80785.1 - 0.083 12.9 0.1 0.083 12.9 0.1 2.9 2 2 0 2 2 2 0 AAA domain TFIIA PF03153.13 EFA80785.1 - 5.1 7.0 34.0 7.8 6.4 34.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1045 PF06299.12 EFA80786.1 - 0.077 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) DUF751 PF05421.11 EFA80786.1 - 0.2 12.4 1.1 0.58 10.9 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF751) PTR2 PF00854.21 EFA80788.1 - 1.1e-96 324.1 6.3 1.1e-96 324.1 6.3 1.8 2 1 0 2 2 2 1 POT family MFS_1 PF07690.16 EFA80788.1 - 1.4e-11 44.0 27.1 9.8e-11 41.2 24.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 EFA80788.1 - 6.7 6.8 15.6 2.7 8.0 0.8 3.7 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III MRAP PF15183.6 EFA80788.1 - 7.3 6.6 6.6 0.61 10.1 0.1 2.5 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Pkinase PF00069.25 EFA80789.1 - 4.2e-19 68.9 0.2 1.2e-18 67.5 0.2 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80789.1 - 7e-14 51.7 0.0 1.2e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFA80789.1 - 0.0064 16.1 0.2 0.0064 16.1 0.2 2.1 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 EFA80789.1 - 0.0077 15.6 0.1 0.015 14.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ribonuc_2-5A PF06479.12 EFA80789.1 - 0.01 16.0 4.0 0.019 15.2 0.0 2.8 2 0 0 2 2 2 0 Ribonuclease 2-5A Ribosomal_S4e PF00900.20 EFA80790.1 - 2.6e-29 101.0 0.3 6.7e-29 99.6 0.3 1.7 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EFA80790.1 - 1.3e-20 72.7 0.1 2.1e-20 72.1 0.1 1.3 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 EFA80790.1 - 8.3e-12 44.6 0.1 1.4e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EFA80790.1 - 0.00026 20.8 0.1 0.0009 19.1 0.1 1.9 1 0 0 1 1 1 1 KOW motif PB1 PF00564.24 EFA80791.1 - 0.00046 20.1 0.1 0.0011 18.9 0.1 1.6 1 0 0 1 1 1 1 PB1 domain Podoplanin PF05808.11 EFA80791.1 - 0.058 13.5 2.0 0.54 10.3 0.0 2.9 2 0 0 2 2 2 0 Podoplanin TMEM154 PF15102.6 EFA80791.1 - 1 9.3 0.0 1 9.3 0.0 3.3 3 0 0 3 3 3 0 TMEM154 protein family DUF2804 PF10974.8 EFA80793.1 - 0.054 13.0 0.1 0.12 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2804) AIDA PF16168.5 EFA80793.1 - 6.4 6.9 9.7 1.5 9.0 2.9 3.2 3 0 0 3 3 3 0 Adhesin of bacterial autotransporter system, probable stalk Beta_helix PF13229.6 EFA80794.1 - 0.0053 16.6 0.1 0.0053 16.6 0.1 2.2 2 1 0 2 2 2 1 Right handed beta helix region RRM_1 PF00076.22 EFA80795.1 - 2.6e-06 27.2 1.5 6.9e-05 22.6 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_2 PF12796.7 EFA80796.1 - 3.8e-18 65.8 3.7 8.8e-06 26.2 0.0 4.9 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80796.1 - 3.2e-12 46.7 4.7 0.02 15.5 0.1 7.7 6 3 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA80796.1 - 1.8e-11 44.1 1.9 0.1 12.9 0.0 8.5 7 1 3 10 10 10 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80796.1 - 9e-09 34.9 0.8 2.1 9.2 0.0 8.5 7 2 2 9 9 9 1 Ankyrin repeat DUF1979 PF09322.10 EFA80796.1 - 0.0032 17.3 0.0 1.8 8.5 0.0 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF1979) FNIP PF05725.12 EFA80798.1 - 5.3e-08 32.9 24.9 7.6e-06 26.0 0.4 7.6 7 1 1 8 8 8 4 FNIP Repeat F-box_5 PF18511.1 EFA80798.1 - 3.2e-05 23.4 0.1 8e-05 22.1 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA80798.1 - 0.016 15.1 0.2 0.041 13.8 0.2 1.6 1 0 0 1 1 1 0 F-box-like EGF_2 PF07974.13 EFA80798.1 - 0.026 14.9 10.9 0.068 13.6 10.9 1.7 1 0 0 1 1 1 0 EGF-like domain Actin PF00022.19 EFA80799.1 - 2.9e-152 507.0 0.0 9.3e-152 505.3 0.0 1.6 1 1 0 1 1 1 1 Actin C2 PF00168.30 EFA80801.1 - 5.8e-09 36.2 0.0 2.1e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 C2 domain DUF365 PF04033.12 EFA80801.1 - 0.084 13.2 0.1 0.084 13.2 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF365) Pyr_redox_2 PF07992.14 EFA80802.1 - 9.5e-66 222.0 2.1 1.4e-65 221.5 2.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFA80802.1 - 1.1e-34 119.0 0.3 2.2e-34 118.0 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFA80802.1 - 2.9e-18 66.2 5.9 7.6e-17 61.7 0.8 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA80802.1 - 5.5e-16 58.7 3.2 4.8e-15 55.6 3.2 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFA80802.1 - 1.8e-08 34.2 0.5 1.5e-05 24.6 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EFA80802.1 - 9.4e-06 24.6 2.2 0.025 13.3 0.5 3.1 3 0 0 3 3 3 2 HI0933-like protein GIDA PF01134.22 EFA80802.1 - 0.00039 19.6 5.5 0.00046 19.4 3.0 2.3 2 1 0 2 2 2 1 Glucose inhibited division protein A K_oxygenase PF13434.6 EFA80802.1 - 0.00085 18.6 0.0 0.0023 17.2 0.0 1.7 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFA80802.1 - 0.002 18.3 2.8 0.0067 16.6 2.8 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA80802.1 - 0.0063 16.1 14.3 0.052 13.1 2.2 3.8 4 1 1 5 5 5 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFA80802.1 - 0.02 14.0 3.1 0.048 12.7 0.4 2.6 3 0 0 3 3 3 0 FAD binding domain Thi4 PF01946.17 EFA80802.1 - 0.036 13.3 0.2 0.086 12.1 0.2 1.6 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EFA80802.1 - 0.043 12.9 0.3 0.65 9.0 0.1 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EFA80802.1 - 0.045 13.7 0.7 4.9 7.1 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFA80802.1 - 0.14 11.4 1.9 0.33 10.1 0.4 2.0 2 0 0 2 2 2 0 FAD binding domain RRM_1 PF00076.22 EFA80803.1 - 0.0011 18.7 0.4 0.0037 17.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4337 PF14235.6 EFA80803.1 - 0.027 14.6 0.3 0.027 14.6 0.3 6.3 3 2 2 5 5 5 0 Domain of unknown function (DUF4337) PRA1 PF03208.19 EFA80804.1 - 2.9e-23 82.1 1.9 4.3e-23 81.5 1.9 1.2 1 0 0 1 1 1 1 PRA1 family protein DUF295 PF03478.18 EFA80804.1 - 0.059 13.0 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF295) DUF3221 PF11518.8 EFA80804.1 - 0.24 11.8 2.6 0.26 11.7 0.9 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3221) KH_2 PF07650.17 EFA80805.1 - 2.4e-12 46.5 0.2 2.4e-12 46.5 0.2 1.6 2 0 0 2 2 2 1 KH domain MMR_HSR1 PF01926.23 EFA80805.1 - 3.6e-07 30.2 0.1 8.4e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFA80805.1 - 2.2e-06 27.8 0.6 3.9e-06 27.0 0.1 1.8 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 EFA80805.1 - 8.5e-05 22.1 0.2 0.00014 21.4 0.2 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 EFA80805.1 - 0.0042 17.6 0.8 0.024 15.1 0.2 2.2 1 1 0 2 2 2 1 ABC transporter FtsK_SpoIIIE PF01580.18 EFA80805.1 - 0.02 14.2 0.3 0.079 12.3 0.0 2.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family Roc PF08477.13 EFA80805.1 - 0.042 14.1 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EFA80805.1 - 0.069 12.4 3.2 0.12 11.7 0.1 2.5 2 1 1 3 3 3 0 Septin AAA_16 PF13191.6 EFA80805.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain F-box-like PF12937.7 EFA80806.1 - 0.048 13.6 0.3 0.54 10.2 0.1 2.4 2 0 0 2 2 2 0 F-box-like LRR_4 PF12799.7 EFA80807.1 - 0.0055 17.1 8.0 2.1 8.9 0.0 4.8 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) RNA_pol_Rpb4 PF03874.16 EFA80807.1 - 0.93 9.8 6.7 0.13 12.6 1.8 2.0 2 1 0 2 2 2 0 RNA polymerase Rpb4 SdrD_B PF17210.3 EFA80808.1 - 4.8e-38 129.8 26.4 1e-07 32.1 0.0 7.2 7 1 1 8 8 8 6 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA80808.1 - 8.7e-08 32.3 16.3 0.074 13.3 0.0 5.8 6 0 0 6 6 6 3 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA80808.1 - 0.012 16.0 16.8 0.49 10.8 0.6 5.0 4 1 0 4 4 4 0 Prealbumin-like fold domain LRR_6 PF13516.6 EFA80809.1 - 4.1e-13 48.2 8.3 0.0018 18.1 0.0 5.3 5 0 0 5 5 5 5 Leucine Rich repeat LRR_9 PF14580.6 EFA80809.1 - 0.0065 16.0 1.3 4 6.9 0.1 2.9 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 EFA80809.1 - 0.0069 16.8 6.1 0.51 10.8 0.1 3.4 2 2 1 3 3 3 2 Leucine Rich repeats (2 copies) FlgT_M PF16539.5 EFA80810.1 - 0.019 15.1 1.5 0.02 15.0 1.5 1.2 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Activator_LAG-3 PF11498.8 EFA80810.1 - 0.11 11.4 5.8 0.13 11.2 5.8 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ESM4 PF15952.5 EFA80810.1 - 0.59 10.5 12.4 0.66 10.4 12.4 1.0 1 0 0 1 1 1 0 Enhancer of split M4 family Ank_5 PF13857.6 EFA80811.1 - 1.5e-32 111.2 13.6 0.00029 21.0 0.1 11.0 1 1 10 11 11 11 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80811.1 - 2e-32 111.1 11.5 2.4e-06 28.0 0.0 8.1 6 2 4 10 10 10 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80811.1 - 2.5e-31 108.1 12.0 1.4e-07 32.0 0.1 5.1 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA80811.1 - 9.8e-16 56.3 3.8 11 7.0 0.0 10.8 9 2 2 11 11 11 2 Ankyrin repeat DUF5049 PF16468.5 EFA80811.1 - 3.3e-07 30.1 0.2 1.8 8.6 0.0 7.6 8 1 1 9 9 9 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA80811.1 - 0.0085 16.5 5.2 70 4.1 0.0 6.7 4 3 1 5 5 5 0 Ankyrin repeat SIR2 PF02146.17 EFA80812.1 - 4.2e-44 150.6 0.0 9.2e-44 149.5 0.0 1.6 1 0 0 1 1 1 1 Sir2 family Ank_2 PF12796.7 EFA80812.1 - 3.1e-40 136.7 18.0 3.6e-12 46.7 0.6 5.3 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80812.1 - 1.4e-32 111.6 13.9 4.5e-11 43.0 0.1 6.6 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFA80812.1 - 6.8e-31 105.4 21.0 0.00054 20.3 0.0 8.9 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 EFA80812.1 - 1.1e-29 102.1 17.3 2.8e-08 33.9 0.1 6.7 4 3 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80812.1 - 1e-24 83.9 16.5 0.00081 19.7 0.0 9.1 9 1 0 9 9 9 6 Ankyrin repeat Abhydrolase_1 PF00561.20 EFA80812.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Dicty_CAR PF05462.11 EFA80814.1 - 1.8e-08 33.9 26.8 2.4e-08 33.5 26.8 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EFA80814.1 - 4.4e-07 29.4 23.1 5.6e-07 29.1 23.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) CitMHS PF03600.16 EFA80814.1 - 0.038 13.2 0.0 0.062 12.5 0.0 1.3 1 1 0 1 1 1 0 Citrate transporter Glyco_hydro_9 PF00759.19 EFA80815.1 - 2.1e-104 350.3 15.6 2.1e-104 350.3 15.6 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 9 Apt1 PF10351.9 EFA80815.1 - 4.5 6.0 9.6 6.8 5.4 9.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PTR2 PF00854.21 EFA80816.1 - 9.9e-102 340.7 12.7 1.4e-101 340.2 12.7 1.2 1 0 0 1 1 1 1 POT family DUF2070 PF09843.9 EFA80816.1 - 0.00062 18.2 4.8 0.00062 18.2 4.8 2.7 1 1 2 3 3 3 1 Predicted membrane protein (DUF2070) MRAP PF15183.6 EFA80816.1 - 0.026 14.5 0.2 0.35 10.9 0.1 2.8 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family zf-RING_2 PF13639.6 EFA80817.1 - 2.5e-09 37.3 8.2 5.3e-09 36.3 8.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFA80817.1 - 2.7e-06 27.6 8.2 8.4e-06 26.0 6.7 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFA80817.1 - 8.4e-06 25.5 7.6 1.9e-05 24.4 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA80817.1 - 6.1e-05 22.8 6.9 0.00012 21.9 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA80817.1 - 0.00013 21.9 4.9 0.00031 20.7 4.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA80817.1 - 0.00016 21.5 8.4 0.00039 20.2 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA80817.1 - 0.00019 21.3 9.0 0.00043 20.2 9.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFA80817.1 - 0.0012 19.0 5.5 0.0027 17.8 5.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING WD40 PF00400.32 EFA80817.1 - 0.0024 18.7 1.0 0.1 13.5 0.3 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat Prok-RING_4 PF14447.6 EFA80817.1 - 0.0076 16.1 5.9 0.023 14.6 5.9 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFA80817.1 - 0.032 14.3 2.1 0.083 13.0 2.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 EFA80817.1 - 0.22 11.4 2.6 0.62 9.9 2.6 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 EFA80817.1 - 0.25 11.5 9.3 2.4 8.4 9.3 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_11 PF17123.5 EFA80817.1 - 0.87 9.4 6.6 2.2 8.1 6.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EFA80817.1 - 1.2 8.9 10.7 0.15 11.7 5.9 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Zn-ribbon_8 PF09723.10 EFA80817.1 - 4.7 7.4 6.0 0.98 9.6 2.3 1.8 2 0 0 2 2 1 0 Zinc ribbon domain zf-RING_4 PF14570.6 EFA80817.1 - 7.1 6.5 7.0 15 5.4 7.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Staph_haemo PF05480.11 EFA80819.1 - 0.0043 16.8 0.3 0.91 9.3 0.0 2.7 2 0 0 2 2 2 2 Staphylococcus haemolytic protein DUF3965 PF13112.6 EFA80820.1 - 0.00066 19.0 0.2 0.0015 17.8 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3965) Staph_haemo PF05480.11 EFA80820.1 - 0.051 13.3 2.6 0.46 10.3 0.0 2.5 2 0 0 2 2 2 0 Staphylococcus haemolytic protein DUF3918 PF13056.6 EFA80821.1 - 0.15 11.7 0.0 0.58 9.8 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) DUF4751 PF15942.5 EFA80822.1 - 0.013 15.5 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4751) SOG2 PF10428.9 EFA80823.1 - 0.13 11.4 13.5 0.13 11.4 13.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein ORC6 PF05460.13 EFA80823.1 - 1.1 8.5 24.2 1.2 8.4 24.2 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ndc1_Nup PF09531.10 EFA80823.1 - 4 6.0 17.3 4 6.0 17.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hamartin PF04388.12 EFA80823.1 - 6.5 5.3 23.7 7.2 5.1 23.7 1.1 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 EFA80823.1 - 8.2 6.0 32.7 0.15 11.6 26.2 1.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein ABC1 PF03109.16 EFA80824.1 - 4.4e-19 68.8 0.0 4.4e-19 68.8 0.0 2.5 2 0 0 2 2 2 1 ABC1 family LIM PF00412.22 EFA80825.1 - 8.8e-35 118.7 63.2 1.5e-11 44.4 3.5 5.9 6 0 0 6 6 6 5 LIM domain PTEN_C2 PF10409.9 EFA80825.1 - 8.7e-23 80.6 0.4 8.7e-23 80.6 0.4 3.0 3 0 0 3 3 3 1 C2 domain of PTEN tumour-suppressor protein SPX PF03105.19 EFA80825.1 - 1.1e-05 25.5 18.3 1.7e-05 24.9 0.0 2.5 2 1 0 2 2 2 1 SPX domain DSPc PF00782.20 EFA80825.1 - 2.2e-05 24.3 0.0 2.2e-05 24.3 0.0 3.2 4 0 0 4 4 4 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFA80825.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFA80825.1 - 0.02 15.0 0.1 0.075 13.1 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate zf-ACC PF17848.1 EFA80825.1 - 0.37 10.9 0.1 0.37 10.9 0.1 7.4 8 0 0 8 8 8 0 Acetyl-coA carboxylase zinc finger domain Ribosomal_L37e PF01907.19 EFA80826.1 - 2.8e-08 33.8 0.7 2.8e-08 33.8 0.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L37e Conotoxin PF02950.17 EFA80828.1 - 0.3 12.1 5.5 0.47 11.5 5.5 1.3 1 0 0 1 1 1 0 Conotoxin zf-CCCH PF00642.24 EFA80829.1 - 3.9e-20 71.3 16.7 3.1e-10 39.7 4.2 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFA80829.1 - 7.3e-12 44.8 11.3 4e-06 26.5 1.8 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFA80829.1 - 3.7e-10 39.5 14.7 3.9e-06 26.7 3.0 2.3 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 EFA80829.1 - 0.0021 18.5 10.9 0.068 13.7 0.9 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EFA80829.1 - 0.031 15.0 0.7 0.031 15.0 0.7 3.5 2 1 2 4 4 4 0 Torus domain AAA_23 PF13476.6 EFA80829.1 - 0.032 14.7 2.2 0.077 13.5 2.2 1.6 1 0 0 1 1 1 0 AAA domain NYN PF01936.18 EFA80830.1 - 5.9e-22 78.7 0.2 5.9e-22 78.7 0.2 3.6 4 0 0 4 4 4 1 NYN domain AMPK1_CBM PF16561.5 EFA80830.1 - 3.4e-18 65.6 0.1 5.2e-14 52.2 0.0 4.3 5 0 0 5 5 5 2 Glycogen recognition site of AMP-activated protein kinase OHA PF14418.6 EFA80830.1 - 2.1e-15 56.3 0.0 2.1e-15 56.3 0.0 3.3 4 0 0 4 4 4 1 OST-HTH Associated domain BSP_II PF05432.11 EFA80830.1 - 0.0073 16.1 15.0 0.0073 16.1 15.0 4.2 4 0 0 4 4 4 1 Bone sialoprotein II (BSP-II) Otopetrin PF03189.13 EFA80830.1 - 1.1 8.0 31.2 7.3 5.3 26.8 2.7 2 1 0 2 2 2 0 Otopetrin Sod_Fe_C PF02777.18 EFA80831.1 - 2.3e-41 140.1 0.5 2.3e-41 140.1 0.5 2.2 2 1 1 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFA80831.1 - 2.4e-30 104.8 3.1 4.5e-30 104.0 3.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Abhydrolase_2 PF02230.16 EFA80831.1 - 0.11 12.2 0.6 0.36 10.6 0.1 1.9 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Sod_Fe_C PF02777.18 EFA80833.1 - 3.2e-41 139.6 0.6 3.2e-41 139.6 0.6 2.2 2 1 1 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFA80833.1 - 1.8e-31 108.4 2.0 3.4e-31 107.6 2.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain TIG PF01833.24 EFA80834.1 - 4.2e-38 129.3 207.7 1.4e-05 25.1 7.2 21.9 17 4 4 21 21 21 17 IPT/TIG domain EGF_2 PF07974.13 EFA80834.1 - 0.0012 19.1 8.3 0.0033 17.7 8.3 1.7 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA80834.1 - 0.0026 18.0 8.1 0.0026 18.0 8.1 2.1 2 0 0 2 2 2 1 EGF-like domain Lectin_C PF00059.21 EFA80834.1 - 0.012 16.4 0.1 0.034 14.9 0.1 1.8 1 0 0 1 1 1 0 Lectin C-type domain RnlB_antitoxin PF15933.5 EFA80834.1 - 0.17 12.2 1.2 0.69 10.3 1.2 2.1 1 0 0 1 1 1 0 Antitoxin to bacterial toxin RNase LS or RnlA EB PF01683.18 EFA80834.1 - 1.7 9.0 7.2 4.6 7.6 7.2 1.7 1 0 0 1 1 1 0 EB module MINDY_DUB PF04424.13 EFA80835.1 - 1.5e-23 83.0 0.0 2.9e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase CarbopepD_reg_2 PF13715.6 EFA80835.1 - 0.0074 16.3 0.0 0.79 9.8 0.0 2.8 3 0 0 3 3 3 1 CarboxypepD_reg-like domain Aminotran_3 PF00202.21 EFA80836.1 - 2.6e-112 375.5 0.0 3.9e-112 374.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III HATPase_c PF02518.26 EFA80836.1 - 2.1e-30 105.5 0.1 5.1e-30 104.3 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA80836.1 - 4.9e-21 75.0 0.1 3.7e-19 69.0 0.0 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFA80836.1 - 1e-19 70.3 0.0 2.5e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain CHASE PF03924.13 EFA80836.1 - 1e-10 41.9 0.0 2.1e-09 37.6 0.0 2.8 2 1 0 2 2 2 1 CHASE domain PAS_3 PF08447.12 EFA80836.1 - 1.2e-07 31.9 0.0 3.6e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 EFA80836.1 - 0.021 14.7 0.0 0.051 13.4 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PUF PF00806.19 EFA80837.1 - 5.4e-24 82.5 1.4 4.2e-07 29.3 0.0 4.5 4 0 0 4 4 4 3 Pumilio-family RNA binding repeat DUF2115 PF09888.9 EFA80838.1 - 0.01 16.4 0.2 0.015 15.8 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) RNA_pol_Rpc4 PF05132.14 EFA80838.1 - 0.046 14.1 0.5 0.068 13.6 0.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 PGA2 PF07543.12 EFA80838.1 - 0.061 13.3 4.3 0.089 12.8 4.3 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 COX6A PF02046.15 EFA80838.1 - 0.069 13.6 0.2 0.11 13.0 0.2 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIa PYST-C1 PF09690.10 EFA80838.1 - 0.76 9.6 8.0 1.8 8.4 8.0 1.6 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) Ribosomal_S10 PF00338.22 EFA80839.1 - 7.7e-24 83.8 0.1 1.6e-23 82.7 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Asp PF00026.23 EFA80839.1 - 3.4e-14 53.0 1.7 7.6e-14 51.8 1.7 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EFA80839.1 - 1.4e-12 47.7 0.0 2.4e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TSP_1 PF00090.19 EFA80839.1 - 1e-06 28.8 26.7 7.8e-05 22.8 6.0 3.8 3 0 0 3 3 3 2 Thrombospondin type 1 domain Phenol_MetA_deg PF13557.6 EFA80839.1 - 2 8.3 8.8 18 5.2 8.9 2.2 1 1 0 1 1 1 0 Putative MetA-pathway of phenol degradation DUF4150 PF13665.6 EFA80840.1 - 0.53 10.4 5.2 1.2 9.3 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4150) Chlam_PMP PF02415.17 EFA80841.1 - 0.00064 20.1 86.2 0.091 13.3 1.7 11.7 11 1 0 11 11 11 6 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat MIF4G PF02854.19 EFA80841.1 - 0.065 12.9 0.2 0.096 12.3 0.2 1.2 1 0 0 1 1 1 0 MIF4G domain fn1 PF00039.18 EFA80841.1 - 0.13 12.5 0.5 0.38 11.0 0.5 1.8 1 0 0 1 1 1 0 Fibronectin type I domain Ank_2 PF12796.7 EFA80842.1 - 0.14 12.7 0.0 0.35 11.5 0.0 1.8 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ribosomal_L7Ae PF01248.26 EFA80843.1 - 0.023 14.4 0.0 0.098 12.4 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family IFT46_B_C PF12317.8 EFA80843.1 - 0.51 10.0 5.0 0.28 10.9 0.3 2.8 3 1 1 4 4 4 0 Intraflagellar transport complex B protein 46 C terminal Glyco_hydro_16 PF00722.21 EFA80846.1 - 8.3e-06 25.4 1.9 1.8e-05 24.3 0.0 2.5 3 0 0 3 3 3 1 Glycosyl hydrolases family 16 MAM PF00629.23 EFA80846.1 - 0.049 13.6 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 MAM domain, meprin/A5/mu Dehydrin PF00257.19 EFA80846.1 - 0.56 10.8 8.6 1.1 9.8 8.6 1.4 1 0 0 1 1 1 0 Dehydrin CCDC53 PF10152.9 EFA80846.1 - 2 8.8 3.7 3.3 8.1 3.7 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF1180 PF06679.12 EFA80846.1 - 5.7 7.3 8.9 11 6.5 8.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Cornichon PF03311.14 EFA80847.1 - 1.7e-35 122.0 11.7 2.1e-35 121.7 11.7 1.0 1 0 0 1 1 1 1 Cornichon protein DUF21 PF01595.20 EFA80848.1 - 3.1e-21 75.9 2.6 5.1e-20 71.9 1.3 2.3 1 1 1 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EFA80848.1 - 2.5e-05 24.6 0.1 0.32 11.5 0.1 2.7 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 EFA80848.1 - 0.00016 21.7 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain LPD38 PF18857.1 EFA80848.1 - 0.067 13.3 0.9 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein associated domain 38 Ank_5 PF13857.6 EFA80849.1 - 6.2e-23 80.6 10.6 0.0039 17.5 0.1 9.9 3 2 8 11 11 11 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80849.1 - 6.7e-21 74.7 8.3 3.2e-06 27.6 0.3 4.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA80849.1 - 4.7e-19 68.5 9.1 0.00062 20.3 0.2 7.6 6 3 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80849.1 - 2.3e-12 45.9 6.3 4.3 8.2 0.1 10.5 7 3 4 11 11 11 2 Ankyrin repeat DUF249 PF03158.13 EFA80849.1 - 0.00024 20.9 4.3 1.1 8.9 0.0 3.6 1 1 0 3 3 3 2 Multigene family 530 protein PatG_C PF18065.1 EFA80849.1 - 0.11 12.4 0.1 1.3 9.0 0.0 2.2 1 1 1 2 2 2 0 PatG C-terminal NST1 PF13945.6 EFA80850.1 - 0.4 10.8 10.1 0.48 10.5 10.1 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator NIF PF03031.18 EFA80851.1 - 7.3e-26 90.8 1.2 2.8e-25 88.9 1.2 2.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EFA80851.1 - 8.2e-10 38.9 1.9 1.9e-09 37.8 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFA80851.1 - 3.1e-08 33.5 0.0 7.5e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain DUF2722 PF10846.8 EFA80851.1 - 0.00052 19.1 14.0 0.00052 19.1 14.0 4.5 4 1 0 4 4 4 1 Protein of unknown function (DUF2722) LIG3_BRCT PF16759.5 EFA80851.1 - 0.0012 19.1 0.1 0.0072 16.6 0.1 2.4 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EFA80851.1 - 0.0057 16.5 1.2 0.031 14.1 0.0 3.0 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EFA80851.1 - 0.0072 16.7 5.9 0.0083 16.5 0.0 3.5 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain Chordopox_RPO7 PF05864.12 EFA80851.1 - 0.052 13.8 0.5 0.26 11.6 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) HD_4 PF13328.6 EFA80851.1 - 1 9.1 4.0 59 3.4 0.0 2.5 2 0 0 2 2 2 0 HD domain Arf PF00025.21 EFA80852.1 - 4.6e-62 208.6 0.1 5.1e-62 208.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA80852.1 - 2e-13 50.6 0.1 2.7e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA80852.1 - 1.8e-12 47.1 0.0 2.2e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA80852.1 - 9.4e-11 41.6 0.1 1.1e-10 41.4 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFA80852.1 - 3.2e-09 36.4 1.9 3.8e-06 26.3 0.9 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFA80852.1 - 4.7e-09 35.9 0.0 6e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA80852.1 - 6.7e-08 32.6 0.1 1e-07 32.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA80852.1 - 0.0054 16.7 0.1 1.2 9.0 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFA80852.1 - 0.0056 16.2 1.5 0.029 13.9 1.5 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF2209 PF09974.9 EFA80852.1 - 0.0062 16.9 0.0 0.0091 16.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) cobW PF02492.19 EFA80852.1 - 0.0085 15.7 0.4 1.9 8.0 0.1 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EFA80852.1 - 0.009 15.6 0.3 0.07 12.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 EFA80852.1 - 0.012 15.5 0.4 2.7 7.9 0.1 2.2 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 EFA80852.1 - 0.015 15.8 0.6 0.032 14.7 0.6 1.6 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EFA80852.1 - 0.015 15.4 0.4 0.028 14.6 0.4 1.6 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFA80852.1 - 0.017 14.8 0.1 0.066 12.8 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MeaB PF03308.16 EFA80852.1 - 0.024 13.6 0.1 1.6 7.6 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PduV-EutP PF10662.9 EFA80852.1 - 0.035 13.8 0.7 0.091 12.5 0.7 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EFA80852.1 - 0.046 13.1 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Arf PF00025.21 EFA80853.1 - 2e-66 222.8 0.3 2.2e-66 222.6 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA80853.1 - 2.4e-15 56.8 0.2 3.2e-15 56.4 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFA80853.1 - 3e-13 49.6 3.2 1.9e-10 40.5 1.1 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFA80853.1 - 1.2e-12 47.8 0.1 1.3e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFA80853.1 - 6.3e-12 45.3 0.0 7.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFA80853.1 - 8.3e-09 35.1 0.0 1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA80853.1 - 2e-07 31.1 0.1 2.9e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EFA80853.1 - 0.00024 21.0 0.6 0.15 12.0 0.0 2.1 2 0 0 2 2 2 2 NACHT domain cobW PF02492.19 EFA80853.1 - 0.0031 17.1 0.6 1.1 8.8 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EFA80853.1 - 0.0086 15.6 0.3 0.11 12.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EFA80853.1 - 0.011 16.3 1.5 0.055 14.0 1.5 1.9 1 1 0 1 1 1 0 ABC transporter MeaB PF03308.16 EFA80853.1 - 0.015 14.3 0.1 0.72 8.8 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 EFA80853.1 - 0.016 15.1 0.3 1.5 8.7 0.0 2.4 1 1 2 3 3 3 0 RsgA GTPase AAA_33 PF13671.6 EFA80853.1 - 0.019 15.2 0.3 0.043 14.0 0.3 1.8 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EFA80853.1 - 0.024 14.2 0.9 0.073 12.6 0.9 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B SRP54 PF00448.22 EFA80853.1 - 0.043 13.4 0.1 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 EFA80853.1 - 0.051 13.3 0.5 0.17 11.7 0.2 1.8 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EFA80853.1 - 0.054 12.9 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Arf PF00025.21 EFA80854.1 - 1.4e-66 223.2 0.2 1.6e-66 223.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA80854.1 - 4.9e-16 59.0 0.2 6.6e-16 58.6 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFA80854.1 - 4.5e-13 49.1 2.9 2.7e-10 40.0 0.9 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFA80854.1 - 6e-13 48.7 0.1 6.6e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFA80854.1 - 7.8e-12 45.0 0.0 9.7e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFA80854.1 - 1.4e-09 37.7 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA80854.1 - 3.3e-07 30.4 0.1 4.9e-07 29.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EFA80854.1 - 0.00016 21.6 0.6 0.15 12.0 0.0 2.1 2 0 0 2 2 2 2 NACHT domain cobW PF02492.19 EFA80854.1 - 0.0032 17.1 0.7 1.2 8.7 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EFA80854.1 - 0.0034 16.9 0.3 0.052 13.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EFA80854.1 - 0.01 16.4 1.3 0.054 14.0 1.3 1.9 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EFA80854.1 - 0.01 15.7 0.3 0.96 9.3 0.0 2.4 1 1 2 3 3 3 0 RsgA GTPase MeaB PF03308.16 EFA80854.1 - 0.015 14.3 0.2 0.72 8.8 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EFA80854.1 - 0.015 15.4 0.4 0.033 14.3 0.4 1.7 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EFA80854.1 - 0.016 14.7 1.3 0.048 13.2 1.3 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B SRP54 PF00448.22 EFA80854.1 - 0.045 13.4 0.1 0.18 11.4 0.1 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 EFA80854.1 - 0.051 13.3 0.4 0.14 11.9 0.3 1.8 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EFA80854.1 - 0.064 12.6 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Hist_deacetyl PF00850.19 EFA80855.1 - 1.5e-80 271.0 0.1 5.1e-80 269.2 0.1 2.0 2 0 0 2 2 2 1 Histone deacetylase domain DENN PF02141.21 EFA80855.1 - 1.2e-39 136.2 4.0 3.1e-39 134.8 4.0 1.8 1 0 0 1 1 1 1 DENN (AEX-3) domain WD40 PF00400.32 EFA80855.1 - 3.4e-35 119.5 23.9 5.5e-05 23.8 0.2 9.6 8 0 0 8 8 8 8 WD domain, G-beta repeat uDENN PF03456.18 EFA80855.1 - 2.8e-15 56.8 0.1 9.5e-15 55.1 0.1 2.0 1 0 0 1 1 1 1 uDENN domain ANAPC4_WD40 PF12894.7 EFA80855.1 - 1e-06 29.0 2.7 0.18 12.1 0.1 4.4 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain SBF2 PF12335.8 EFA80855.1 - 3.1e-05 23.7 3.7 0.0002 21.1 3.7 2.1 1 1 0 1 1 1 1 Myotubularin protein DUF5613 PF18467.1 EFA80855.1 - 0.19 12.1 4.1 2.4 8.6 0.3 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5613) WD40 PF00400.32 EFA80856.1 - 3e-38 129.1 16.7 2.2e-08 34.6 0.6 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80856.1 - 2.3e-20 72.7 4.5 7.8e-07 29.3 0.1 6.5 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA80856.1 - 1.8e-05 24.8 0.9 0.0091 15.9 0.1 3.2 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A SGL PF08450.12 EFA80856.1 - 0.0041 16.7 0.1 0.081 12.5 0.1 2.6 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 EFA80856.1 - 0.064 11.8 0.1 3.5 6.1 0.0 2.9 2 2 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 EFA80856.1 - 0.078 12.9 0.0 22 5.1 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat OmpH PF03938.14 EFA80856.1 - 0.38 11.1 13.6 0.73 10.2 13.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 EFA80856.1 - 4.6 6.5 6.0 7.2 5.9 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) adh_short PF00106.25 EFA80857.1 - 3.7e-44 150.5 0.0 5e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA80857.1 - 1.4e-31 109.9 0.0 1.8e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA80857.1 - 2.4e-12 47.1 0.0 3.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA80857.1 - 5.7e-06 26.0 0.4 2.9e-05 23.6 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA80857.1 - 3.7e-05 23.7 0.0 4.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFA80857.1 - 5.6e-05 22.7 0.3 0.00025 20.5 0.3 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 EFA80857.1 - 0.00057 19.3 0.0 0.00086 18.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 EFA80857.1 - 0.0014 17.8 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain ADH_zinc_N PF00107.26 EFA80857.1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Mit_KHE1 PF10173.9 EFA80858.1 - 1.3e-38 133.0 0.7 1.3e-38 133.0 0.7 1.9 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related Pex14_N PF04695.13 EFA80858.1 - 1.1 9.9 8.3 16 6.2 0.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MGC-24 PF05283.11 EFA80858.1 - 3.8 7.9 13.6 6.9 7.1 13.6 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Menin PF05053.13 EFA80858.1 - 5.2 5.3 13.4 8.5 4.6 13.4 1.2 1 0 0 1 1 1 0 Menin RAMP4 PF06624.12 EFA80860.1 - 6e-20 71.1 0.4 7.6e-20 70.7 0.4 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 COX16 PF14138.6 EFA80860.1 - 1.3 9.6 4.7 1.9 9.0 0.4 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 SNARE PF05739.19 EFA80861.1 - 2e-09 37.3 1.0 3e-09 36.7 1.0 1.3 1 0 0 1 1 1 1 SNARE domain AKNA PF12443.8 EFA80861.1 - 0.053 14.2 0.1 0.1 13.3 0.0 1.5 1 1 0 1 1 1 0 AT-hook-containing transcription factor Phage_Gp23 PF10669.9 EFA80861.1 - 0.066 13.6 2.2 0.066 13.6 2.2 2.3 1 1 2 3 3 3 0 Protein gp23 (Bacteriophage A118) ATP-synt_J PF04911.12 EFA80863.1 - 0.11 12.2 0.2 0.15 11.7 0.2 1.2 1 0 0 1 1 1 0 ATP synthase j chain FA_desaturase PF00487.24 EFA80864.1 - 2.1e-19 70.3 18.9 2.1e-19 70.3 18.9 1.5 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 EFA80864.1 - 0.00092 18.7 0.2 0.0018 17.7 0.2 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) PhosphMutase PF10143.9 EFA80865.1 - 1.4e-46 158.5 0.0 2.1e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 EFA80865.1 - 1.3e-31 109.8 0.0 1.6e-31 109.6 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 EFA80865.1 - 0.0038 16.9 0.0 0.0049 16.5 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase RCR PF12273.8 EFA80867.1 - 0.0029 18.2 2.7 0.0029 18.2 2.7 1.7 2 0 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red PelG PF16933.5 EFA80867.1 - 0.003 16.5 8.3 0.042 12.7 0.9 2.1 1 1 1 2 2 2 2 Putative exopolysaccharide Exporter (EPS-E) Tim17 PF02466.19 EFA80867.1 - 0.048 14.0 0.1 0.25 11.7 0.1 2.1 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family DUF2371 PF10177.9 EFA80867.1 - 0.096 12.9 0.6 0.21 11.8 0.4 1.7 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) JTB PF05439.12 EFA80867.1 - 0.15 12.1 5.5 0.47 10.5 1.6 2.9 2 1 1 3 3 3 0 Jumping translocation breakpoint protein (JTB) DUF3976 PF13121.6 EFA80867.1 - 0.17 12.1 0.2 0.17 12.1 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3976) DUF4806 PF16064.5 EFA80867.1 - 0.26 11.6 1.2 0.7 10.2 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4806) Cation_ATPase_C PF00689.21 EFA80867.1 - 0.58 9.8 5.8 0.87 9.3 5.8 1.4 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus SurA_N_2 PF13623.6 EFA80867.1 - 2.2 8.2 6.2 0.28 11.0 1.7 1.9 2 0 0 2 2 2 0 SurA N-terminal domain DUF5102 PF17104.5 EFA80868.1 - 4e-05 23.8 7.2 4e-05 23.8 7.2 8.7 4 3 4 8 8 8 4 Domain of unknown function (DUF5102) Ank_4 PF13637.6 EFA80869.1 - 1.9e-17 63.4 0.6 3.9e-07 30.5 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA80869.1 - 2.9e-16 59.8 4.8 8.6e-07 29.5 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80869.1 - 3.3e-15 56.0 0.2 0.014 15.7 0.0 5.6 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80869.1 - 4.2e-10 39.0 0.0 6.2 7.7 0.0 6.2 6 0 0 6 6 6 3 Ankyrin repeat Ndc80_HEC PF03801.13 EFA80869.1 - 0.048 13.3 1.9 0.39 10.3 0.1 2.4 1 1 0 2 2 2 0 HEC/Ndc80p family Ank PF00023.30 EFA80869.1 - 0.1 13.1 0.1 66 4.2 0.0 4.0 4 1 1 5 5 5 0 Ankyrin repeat TPR_1 PF00515.28 EFA80870.1 - 2.1e-07 30.4 0.8 0.074 12.9 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA80870.1 - 1.2e-06 28.1 0.3 2.4 8.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA80870.1 - 3.3e-06 26.9 1.8 0.029 14.6 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA80870.1 - 0.018 14.7 0.1 2.2 8.0 0.1 2.6 2 0 0 2 2 2 0 TPR repeat Ocnus PF05005.15 EFA80871.1 - 1.2 9.3 15.0 18 5.5 0.4 5.3 5 0 0 5 5 5 0 Janus/Ocnus family (Ocnus) Ribosomal_L7Ae PF01248.26 EFA80872.1 - 1.1e-24 86.0 1.5 1.4e-24 85.6 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pox_P35 PF03213.14 EFA80873.1 - 0.0041 16.4 2.7 0.0044 16.3 2.7 1.1 1 0 0 1 1 1 1 Poxvirus P35 protein Carn_acyltransf PF00755.20 EFA80873.1 - 0.082 11.5 2.6 0.097 11.3 2.6 1.0 1 0 0 1 1 1 0 Choline/Carnitine o-acyltransferase GerA PF03323.13 EFA80873.1 - 0.11 10.9 2.1 0.13 10.7 2.1 1.0 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein PPL5 PF18168.1 EFA80873.1 - 0.21 10.8 6.7 0.27 10.5 6.7 1.0 1 0 0 1 1 1 0 Prim-pol family 5 CRT10 PF08728.10 EFA80873.1 - 0.32 9.1 5.5 0.35 9.0 5.5 1.1 1 0 0 1 1 1 0 CRT10 DUF5352 PF17303.2 EFA80873.1 - 0.36 10.7 4.5 0.48 10.3 4.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5352) Cyclin_N PF00134.23 EFA80874.1 - 0.00083 19.1 2.6 0.0027 17.5 2.6 1.9 1 1 0 1 1 1 1 Cyclin, N-terminal domain Glyco_hydro_20 PF00728.22 EFA80875.1 - 4.3e-10 39.5 4.4 2.6e-08 33.6 4.4 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 EFA80875.1 - 1.1e-05 26.2 0.0 2.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 PF14845.6 EFA80875.1 - 0.0015 19.2 0.0 0.0043 17.7 0.0 1.9 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Amidohydro_2 PF04909.14 EFA80876.1 - 5.2e-09 36.3 0.0 8e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase SIS PF01380.22 EFA80877.1 - 2.6e-08 33.8 1.4 1.7e-06 27.9 0.3 2.7 2 1 0 2 2 2 2 SIS domain SIS_2 PF13580.6 EFA80877.1 - 0.0044 17.1 0.0 3 7.9 0.0 3.0 2 1 1 3 3 3 2 SIS domain Nup54 PF13874.6 EFA80878.1 - 6e-06 26.4 2.5 0.00015 21.9 3.9 2.1 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 DUF2838 PF10998.8 EFA80878.1 - 0.011 16.0 1.2 0.011 16.0 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) CN_hydrolase PF00795.22 EFA80879.1 - 2e-50 171.6 0.0 2.3e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Y1_Tnp PF01797.16 EFA80879.1 - 0.058 13.5 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 Transposase IS200 like Ank_2 PF12796.7 EFA80880.1 - 1.2e-33 115.5 14.4 2.4e-08 34.4 0.1 6.6 4 2 1 6 6 6 5 Ankyrin repeats (3 copies) RNA_pol_I_A49 PF06870.12 EFA80880.1 - 6.7e-33 114.1 14.0 6.7e-33 114.1 14.0 1.9 2 1 0 2 2 2 1 A49-like RNA polymerase I associated factor Ank_5 PF13857.6 EFA80880.1 - 8.9e-22 76.9 14.7 0.48 10.8 0.1 12.5 6 3 7 13 13 13 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA80880.1 - 5.1e-19 68.4 17.4 0.00079 19.9 0.1 9.2 7 3 2 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80880.1 - 1e-14 53.1 8.7 1.8 9.4 0.0 12.1 13 0 0 13 13 13 3 Ankyrin repeat DUF5049 PF16468.5 EFA80880.1 - 0.00054 19.8 3.7 66 3.5 0.0 7.4 7 1 1 8 8 8 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA80880.1 - 0.063 13.8 8.3 63 4.3 0.0 7.0 6 3 1 7 7 7 0 Ankyrin repeat Methyltransf_11 PF08241.12 EFA80880.1 - 0.09 13.4 0.2 0.43 11.3 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Cyt-b5 PF00173.28 EFA80881.1 - 1.1e-17 63.9 0.1 1.2e-17 63.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_1 PF00515.28 EFA80883.1 - 0.12 12.2 0.1 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Kelch_1 PF01344.25 EFA80884.1 - 2.8e-17 62.0 9.3 2.2e-06 27.1 0.8 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EFA80884.1 - 6.3e-14 51.7 9.8 0.0073 16.3 0.4 5.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA80884.1 - 1.2e-12 47.6 10.2 0.0061 16.8 0.4 5.8 4 2 2 6 6 6 4 Kelch motif zf-B_box PF00643.24 EFA80884.1 - 3.5e-05 23.9 11.4 6.9e-05 22.9 11.4 1.4 1 0 0 1 1 1 1 B-box zinc finger Kelch_2 PF07646.15 EFA80884.1 - 4.8e-05 23.2 8.2 0.045 13.7 0.8 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFA80884.1 - 5.2e-05 23.1 13.0 0.68 10.0 0.2 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EFA80884.1 - 0.00069 19.8 16.5 0.00077 19.7 0.3 5.7 6 1 0 6 6 5 1 Galactose oxidase, central domain AdoMet_Synthase PF01941.19 EFA80884.1 - 0.018 13.8 0.3 0.037 12.8 0.3 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) GPS2_interact PF15784.5 EFA80884.1 - 0.032 14.7 0.6 0.032 14.7 0.6 2.3 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Rab_bind PF16704.5 EFA80884.1 - 0.35 10.9 2.9 1.5 8.9 0.2 2.7 2 1 0 2 2 2 0 Rab binding domain Allexi_40kDa PF05549.11 EFA80884.1 - 1.2 8.5 9.1 0.11 12.0 3.5 2.0 2 0 0 2 2 2 0 Allexivirus 40kDa protein FapA PF03961.13 EFA80884.1 - 2.6 6.6 7.7 0.95 8.0 5.1 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 EFA80884.1 - 3.6 7.1 6.2 5.1 6.6 5.0 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit Synaptonemal_3 PF15191.6 EFA80884.1 - 4.9 7.0 6.9 3.4 7.5 3.5 2.5 2 1 0 2 2 2 0 Synaptonemal complex central element protein 3 Spermine_synth PF01564.17 EFA80885.1 - 3.8e-07 29.7 0.5 5.6e-07 29.2 0.5 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_25 PF13649.6 EFA80885.1 - 0.0016 19.1 0.0 0.0039 17.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA80885.1 - 0.14 12.9 0.0 0.25 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain POP1 PF06978.11 EFA80886.1 - 0.0002 21.4 3.3 0.00023 21.2 3.3 1.1 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 ATP-synt_E PF05680.12 EFA80886.1 - 0.035 14.4 5.5 0.042 14.2 5.5 1.2 1 0 0 1 1 1 0 ATP synthase E chain RBM39linker PF15519.6 EFA80886.1 - 0.068 14.3 2.1 0.085 14.0 2.1 1.1 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Spt20 PF12090.8 EFA80886.1 - 0.14 11.8 17.7 0.15 11.7 17.7 1.1 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 EFA80886.1 - 0.26 10.1 11.8 0.29 9.9 11.8 1.0 1 0 0 1 1 1 0 Androgen receptor Presenilin PF01080.17 EFA80886.1 - 1.5 7.5 3.8 1.4 7.6 3.8 1.0 1 0 0 1 1 1 0 Presenilin Cyclin_N PF00134.23 EFA80887.1 - 3.4e-09 36.5 0.1 6.3e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EFA80887.1 - 5.3e-07 30.1 5.1 2.4e-06 28.0 5.1 2.2 1 1 0 1 1 1 1 Cyclin GATA PF00320.27 EFA80888.1 - 2.8e-14 52.4 8.6 2.8e-14 52.4 8.6 2.1 2 0 0 2 2 2 1 GATA zinc finger Med6 PF04934.14 EFA80888.1 - 0.16 11.7 12.1 1 9.2 12.5 2.1 1 1 0 1 1 1 0 MED6 mediator sub complex component ACOX PF01756.19 EFA80889.1 - 1.1e-06 28.3 0.4 2e-06 27.5 0.4 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Mcl1_mid PF12341.8 EFA80890.1 - 5.2e-74 249.3 2.9 1.6e-72 244.4 0.0 2.6 2 1 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EFA80890.1 - 4.2e-26 90.7 10.1 2.7e-06 28.0 0.1 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80890.1 - 1.1e-16 60.9 0.7 0.00013 22.1 0.1 7.0 3 1 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA80890.1 - 0.00016 21.6 3.8 0.051 13.5 0.4 2.8 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A HPS3_N PF14761.6 EFA80890.1 - 0.0033 17.0 0.5 0.56 9.7 0.0 3.9 3 1 2 5 5 5 1 Hermansky-Pudlak syndrome 3 PD40 PF07676.12 EFA80890.1 - 0.011 15.6 0.1 7.2 6.7 0.0 4.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat WD40_3 PF15911.5 EFA80890.1 - 0.02 14.9 1.0 0.12 12.4 0.0 2.9 4 0 0 4 4 4 0 WD domain, G-beta repeat HUN PF08729.10 EFA80890.1 - 0.23 11.5 5.7 0.61 10.1 5.7 1.7 1 0 0 1 1 1 0 HPC2 and ubinuclein domain Phage_30_3 PF08010.11 EFA80891.1 - 0.013 15.3 0.2 0.015 15.1 0.2 1.0 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 DUF2973 PF11189.8 EFA80891.1 - 1.5 9.0 3.3 3.4 7.8 3.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2973) WD40 PF00400.32 EFA80892.1 - 1.7e-16 60.3 0.7 3e-06 27.8 0.3 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80892.1 - 2.9e-07 30.7 0.3 0.016 15.5 0.0 3.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 EFA80892.1 - 0.00097 18.7 13.4 0.00097 18.7 13.4 2.2 2 0 0 2 2 2 2 SDA1 BUD22 PF09073.10 EFA80892.1 - 0.05 13.0 39.0 0.021 14.2 14.6 2.3 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 EFA80892.1 - 1.6 6.9 50.0 1.8 6.6 17.5 2.1 2 0 0 2 2 2 0 Nop14-like family Cwf_Cwc_15 PF04889.12 EFA80892.1 - 5.1 6.7 50.1 2.3 7.9 19.4 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein ESM4 PF15952.5 EFA80892.1 - 8.9 6.7 30.2 1.2 9.6 13.1 2.4 2 0 0 2 2 2 0 Enhancer of split M4 family ATP-synt_D PF01813.17 EFA80894.1 - 1.4e-65 220.8 4.5 2.1e-65 220.2 4.5 1.2 1 0 0 1 1 1 1 ATP synthase subunit D Abhydrolase_3 PF07859.13 EFA80895.1 - 7.7e-19 68.4 0.1 1.9e-18 67.1 0.1 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 EFA80895.1 - 8e-12 44.8 0.1 8e-12 44.8 0.1 1.8 2 1 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 EFA80895.1 - 8.5e-08 31.9 0.1 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFA80895.1 - 0.0018 17.6 0.0 1.4 8.2 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EFA80895.1 - 0.016 14.8 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Serine hydrolase (FSH1) MPM1 PF17234.2 EFA80895.1 - 3.2 8.0 5.9 29 4.9 0.1 2.5 2 1 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Pkinase PF00069.25 EFA80896.1 - 1.8e-59 201.3 0.0 3e-59 200.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80896.1 - 2.3e-38 132.0 0.0 3.4e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA80896.1 - 0.017 13.9 0.0 0.017 13.9 0.0 4.1 3 1 0 3 3 3 0 Fungal protein kinase Peptidase_S9 PF00326.21 EFA80897.1 - 5.7e-41 140.3 0.0 8.8e-41 139.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EFA80897.1 - 1.2e-08 34.8 0.0 2.1e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFA80897.1 - 0.00057 19.2 0.4 0.0042 16.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 AXE1 PF05448.12 EFA80897.1 - 0.0024 16.6 0.2 0.68 8.6 0.1 3.1 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) PD40 PF07676.12 EFA80897.1 - 0.0058 16.6 1.8 0.025 14.5 0.0 3.0 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Peptidase_S15 PF02129.18 EFA80897.1 - 0.026 14.1 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4090 PF13319.6 EFA80897.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) Amidohydro_2 PF04909.14 EFA80901.1 - 7.1e-12 45.7 0.0 9e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase U-box PF04564.15 EFA80902.1 - 2.8e-14 53.1 0.1 9.7e-14 51.3 0.1 1.9 1 0 0 1 1 1 1 U-box domain Acetyltransf_1 PF00583.25 EFA80902.1 - 1.9e-08 34.5 0.0 4.5e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family zf-rbx1 PF12678.7 EFA80902.1 - 2.2e-07 31.1 0.0 5.8e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.8 EFA80902.1 - 7.7e-07 28.8 0.0 2.1e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Acetyltransf_10 PF13673.7 EFA80902.1 - 9.9e-07 28.7 0.0 2.7e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-RING_2 PF13639.6 EFA80902.1 - 1.5e-06 28.4 0.1 5e-06 26.8 0.1 1.9 1 0 0 1 1 1 1 Ring finger domain Acetyltransf_7 PF13508.7 EFA80902.1 - 2.8e-06 27.6 0.0 7e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-C3HC4_2 PF13923.6 EFA80902.1 - 5.1e-05 23.0 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA80902.1 - 0.00071 19.5 0.1 0.0033 17.4 0.0 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA80902.1 - 0.00087 19.1 0.0 0.0024 17.7 0.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FR47 PF08445.10 EFA80902.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Prok-RING_4 PF14447.6 EFA80902.1 - 0.035 14.0 0.1 0.097 12.6 0.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFA80902.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFA80902.1 - 0.062 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1676 PF07898.13 EFA80902.1 - 0.28 11.2 3.3 0.65 10.0 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) RisS_PPD PF16524.5 EFA80902.1 - 3 8.1 5.3 1.3 9.3 0.2 2.6 2 1 0 2 2 2 0 Periplasmic domain of Sensor histidine kinase RisS Oxysterol_BP PF01237.18 EFA80903.1 - 9e-44 149.8 13.1 4.1e-39 134.5 0.2 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein Arrestin_C PF02752.22 EFA80903.1 - 0.14 12.6 0.4 1.9 8.9 0.1 2.5 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain DUF3430 PF11912.8 EFA80904.1 - 3.2e-09 37.2 18.7 4.2e-09 36.8 18.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) F-box_5 PF18511.1 EFA80905.1 - 0.059 13.0 0.0 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 F-box zf-RING_2 PF13639.6 EFA80907.1 - 4.9e-07 30.0 13.3 4.9e-07 30.0 13.3 2.4 2 0 0 2 2 2 1 Ring finger domain zf-B_box PF00643.24 EFA80907.1 - 9.8e-07 28.8 7.7 9.8e-07 28.8 7.7 3.2 3 1 0 3 3 3 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EFA80907.1 - 1.9e-06 27.6 10.0 1.9e-06 27.6 10.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA80907.1 - 0.00052 19.8 13.4 0.00052 19.8 13.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA80907.1 - 0.0011 18.7 10.9 0.0011 18.7 10.9 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFA80907.1 - 0.0038 17.1 14.0 0.0038 17.1 14.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA80907.1 - 0.017 15.4 10.0 0.017 15.4 10.0 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain C1_4 PF07975.12 EFA80907.1 - 2 8.7 19.3 0.5 10.7 5.1 3.1 2 0 0 2 2 2 0 TFIIH C1-like domain SpoU_methylase PF00588.19 EFA80908.1 - 4.8e-30 104.6 0.0 1.5e-29 103.0 0.0 1.9 2 0 0 2 2 2 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EFA80908.1 - 4.4e-08 33.3 0.1 5.9e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 RNA 2'-O ribose methyltransferase substrate binding SNARE PF05739.19 EFA80909.1 - 2.9e-11 43.2 0.9 2.9e-11 43.2 0.9 3.1 4 0 0 4 4 4 1 SNARE domain CheY-binding PF09078.11 EFA80909.1 - 0.0048 17.0 0.1 0.015 15.4 0.1 1.8 1 0 0 1 1 1 1 CheY binding Syntaxin PF00804.25 EFA80909.1 - 0.049 13.3 16.7 0.12 12.0 0.2 3.0 2 1 1 3 3 3 0 Syntaxin Syntaxin-5_N PF11416.8 EFA80909.1 - 0.094 12.0 1.6 0.15 11.3 0.0 2.2 2 0 0 2 2 2 0 Syntaxin-5 N-terminal, Sly1p-binding domain DUF5344 PF17279.2 EFA80909.1 - 0.18 12.4 0.2 0.18 12.4 0.2 3.5 3 1 0 3 3 3 0 Family of unknown function (DUF5344) Syntaxin_2 PF14523.6 EFA80909.1 - 3.4 8.1 22.7 5.4 7.4 7.2 3.5 3 1 0 3 3 3 0 Syntaxin-like protein polyprenyl_synt PF00348.17 EFA80911.1 - 4.6e-57 193.0 0.1 5.3e-57 192.8 0.1 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase USP7_ICP0_bdg PF12436.8 EFA80912.1 - 5.7e-38 130.6 0.5 1.5e-37 129.2 0.5 1.8 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 Ubiquitin_2 PF14560.6 EFA80912.1 - 0.0035 17.7 0.6 0.11 13.0 0.1 3.6 4 0 0 4 4 4 1 Ubiquitin-like domain ubiquitin PF00240.23 EFA80912.1 - 0.015 15.0 0.1 0.14 11.9 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin family Dapper PF15268.6 EFA80912.1 - 0.059 12.2 5.7 0.088 11.7 5.7 1.2 1 0 0 1 1 1 0 Dapper YukD PF08817.10 EFA80912.1 - 0.095 13.4 0.0 0.32 11.7 0.0 1.8 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Presenilin PF01080.17 EFA80912.1 - 1.2 7.8 15.0 2.4 6.9 15.0 1.4 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 EFA80912.1 - 6.8 6.6 22.8 13 5.7 22.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hydrolase_4 PF12146.8 EFA80913.1 - 5.4e-14 52.0 0.0 2.4e-07 30.3 0.0 2.5 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA80913.1 - 7.9e-14 51.9 0.1 2.5e-07 30.6 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold BAAT_C PF08840.11 EFA80913.1 - 3e-08 33.8 0.0 0.0051 16.8 0.0 2.6 2 1 1 3 3 3 2 BAAT / Acyl-CoA thioester hydrolase C terminal AXE1 PF05448.12 EFA80913.1 - 4.1e-05 22.4 0.2 0.0023 16.7 0.0 2.5 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 EFA80913.1 - 4.5e-05 23.2 0.0 0.0017 18.0 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EFA80913.1 - 5.4e-05 22.8 0.0 0.0003 20.4 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EFA80913.1 - 5.4e-05 22.8 0.0 0.00026 20.6 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EFA80913.1 - 0.00019 21.3 0.1 0.57 9.9 0.1 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFA80913.1 - 0.00054 20.6 0.0 0.0039 17.8 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.12 EFA80913.1 - 0.047 12.6 0.0 0.086 11.8 0.0 1.4 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Abhydrolase_3 PF07859.13 EFA80913.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold GATA PF00320.27 EFA80914.1 - 9.4e-17 60.3 6.6 2e-16 59.3 6.6 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EFA80914.1 - 0.48 10.0 2.3 1.1 8.9 2.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Exonuc_VII_L PF02601.15 EFA80914.1 - 0.96 9.0 15.3 1.9 8.0 7.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit GATA PF00320.27 EFA80915.1 - 1.7e-14 53.1 2.9 4.9e-14 51.6 2.9 1.8 1 0 0 1 1 1 1 GATA zinc finger RPW8 PF05659.11 EFA80915.1 - 0.061 13.0 0.4 0.11 12.2 0.4 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 YjcB PF15940.5 EFA80917.1 - 0.048 13.9 0.1 0.058 13.6 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function bMG10 PF17973.1 EFA80918.1 - 3.8e-23 82.1 0.1 9.1e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M PF00207.22 EFA80918.1 - 1.5e-09 37.6 0.0 5e-09 35.9 0.0 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFA80918.1 - 3e-06 27.6 0.0 2.7e-05 24.6 0.0 2.7 2 0 0 2 2 2 1 MG2 domain bMG3 PF11974.8 EFA80918.1 - 0.022 14.8 0.0 0.055 13.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain SAVED PF18145.1 EFA80918.1 - 0.1 12.4 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain Trypan_PARP PF05887.11 EFA80918.1 - 6.1 6.8 16.9 12 5.8 16.9 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_S10 PF00450.22 EFA80920.1 - 9.2e-107 358.0 5.8 1.2e-106 357.7 5.8 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase CBM49 PF09478.10 EFA80921.1 - 1.2e-17 64.0 1.3 2.2e-17 63.1 1.3 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Ras PF00071.22 EFA80922.1 - 1.3e-07 31.4 3.4 8.7 5.9 0.1 6.7 6 1 0 6 6 6 2 Ras family Roc PF08477.13 EFA80922.1 - 0.00011 22.3 0.0 0.72 10.1 0.0 3.1 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Colicin_Pyocin PF01320.18 EFA80922.1 - 0.0017 18.4 1.2 0.66 10.1 0.1 3.1 2 0 0 2 2 2 2 Colicin immunity protein / pyocin immunity protein 7tm_6 PF02949.20 EFA80922.1 - 0.038 13.1 0.0 0.09 11.8 0.0 1.6 1 0 0 1 1 1 0 7tm Odorant receptor HycH PF07450.11 EFA80922.1 - 0.084 13.2 0.1 0.26 11.7 0.1 1.9 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH AAA_lid_10 PF17872.1 EFA80922.1 - 0.18 12.0 0.1 0.18 12.0 0.1 3.2 4 0 0 4 4 4 0 AAA lid domain CENP-H PF05837.12 EFA80922.1 - 0.44 11.0 4.5 2.8 8.4 0.0 3.5 4 0 0 4 4 4 0 Centromere protein H (CENP-H) Ras PF00071.22 EFA80923.1 - 0.0028 17.3 0.2 0.029 14.0 0.2 2.2 1 1 0 1 1 1 1 Ras family Exo70 PF03081.15 EFA80924.1 - 4.8e-18 65.4 6.4 1.6e-16 60.3 2.0 3.2 3 1 1 4 4 4 2 Exo70 exocyst complex subunit Sec34 PF04136.15 EFA80924.1 - 8.2e-05 22.5 2.2 0.00035 20.5 2.2 2.1 1 0 0 1 1 1 1 Sec34-like family DASH_Dad2 PF08654.10 EFA80924.1 - 0.013 15.9 0.2 0.1 13.0 0.1 2.5 1 1 1 2 2 2 0 DASH complex subunit Dad2 PIG-F PF06699.11 EFA80925.1 - 1.5e-32 113.2 9.7 2.1e-32 112.7 9.4 1.4 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F Polysacc_synt_3 PF13440.6 EFA80925.1 - 0.00055 19.2 1.0 0.00055 19.2 1.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Transgly_assoc PF04226.13 EFA80925.1 - 0.13 12.6 5.2 0.072 13.4 1.9 2.4 2 0 0 2 2 2 0 Transglycosylase associated protein NAD_binding_10 PF13460.6 EFA80926.1 - 5.3e-12 46.0 0.0 6.5e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EFA80926.1 - 2.3e-06 28.0 0.1 9.4e-06 26.1 0.0 1.9 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain HIM1 PF08732.10 EFA80926.1 - 0.0022 17.5 0.0 0.0035 16.9 0.0 1.4 1 1 0 1 1 1 1 HIM1 Epimerase PF01370.21 EFA80926.1 - 0.0055 16.2 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFA80926.1 - 0.05 12.8 0.1 2.1 7.4 0.0 2.1 1 1 1 2 2 2 0 Male sterility protein RmlD_sub_bind PF04321.17 EFA80926.1 - 0.06 12.4 0.1 0.39 9.8 0.0 2.1 2 1 0 2 2 2 0 RmlD substrate binding domain DapB_N PF01113.20 EFA80926.1 - 0.086 13.0 0.1 0.16 12.1 0.1 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Pesticin PF16754.5 EFA80926.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin homologue of phage lysozyme, C-term BLM10_mid PF16507.5 EFA80927.1 - 6.3e-61 206.6 10.9 2e-59 201.6 10.9 2.5 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EFA80927.1 - 1.2e-28 98.8 0.1 8.7e-28 96.1 0.1 2.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) CLASP_N PF12348.8 EFA80927.1 - 8.8e-06 25.4 1.1 0.0011 18.6 0.2 3.9 3 1 1 4 4 4 1 CLASP N terminal Androgen_recep PF02166.16 EFA80927.1 - 0.37 9.6 3.0 0.56 9.0 3.0 1.1 1 0 0 1 1 1 0 Androgen receptor RGS PF00615.19 EFA80927.1 - 0.86 9.9 5.8 3 8.1 0.5 4.3 4 0 0 4 4 4 0 Regulator of G protein signaling domain Ras PF00071.22 EFA80929.1 - 0.0014 18.3 7.2 0.24 11.0 1.3 3.5 2 2 0 2 2 2 2 Ras family PRANC PF09372.10 EFA80929.1 - 0.013 15.8 13.0 1.8 8.9 0.0 5.3 4 1 0 5 5 5 0 PRANC domain Maf PF02545.14 EFA80929.1 - 0.044 13.6 0.5 1.3 8.8 0.0 2.7 3 0 0 3 3 3 0 Maf-like protein UCR_14kD PF02271.16 EFA80929.1 - 0.081 12.9 0.9 2.3 8.3 0.2 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit PRC2_HTH_1 PF18118.1 EFA80929.1 - 0.26 12.1 15.0 0.99 10.2 1.8 3.7 3 1 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain PduV-EutP PF10662.9 EFA80929.1 - 0.35 10.6 5.5 5.2 6.8 0.2 2.9 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation DUF4549 PF15082.6 EFA80929.1 - 0.6 9.9 9.8 2.3 8.0 1.6 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4549) CAP59_mtransfer PF11735.8 EFA80930.1 - 0.003 17.3 1.1 0.003 17.3 1.1 1.7 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 DUF3446 PF11928.8 EFA80930.1 - 7.8 6.9 12.9 7.6 6.9 3.8 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF445 PF04286.12 EFA80931.1 - 0.037 13.9 1.1 0.043 13.6 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Selenoprotein_S PF06936.11 EFA80932.1 - 0.018 14.8 1.4 0.027 14.3 1.4 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) RNA_GG_bind PF10258.9 EFA80933.1 - 3.7e-08 33.3 0.6 0.0033 17.4 0.2 2.8 2 0 0 2 2 2 2 PHAX RNA-binding domain Macoilin PF09726.9 EFA80933.1 - 0.18 10.4 18.2 0.23 10.0 18.2 1.2 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 EFA80933.1 - 0.62 9.6 26.6 0.51 9.9 13.4 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Dsh_C PF12316.8 EFA80933.1 - 0.63 10.4 4.9 0.98 9.8 4.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4407 PF14362.6 EFA80933.1 - 4.7 6.5 6.6 9.1 5.5 6.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_C1 PF00112.23 EFA80934.1 - 6.4e-75 252.0 2.9 6.4e-75 252.0 2.9 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA80934.1 - 2.8e-15 56.5 5.0 6e-15 55.4 5.0 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) RasGAP_C PF03836.15 EFA80934.1 - 0.0013 18.9 0.8 0.0021 18.2 0.8 1.2 1 0 0 1 1 1 1 RasGAP C-terminus NUDIX_2 PF13869.6 EFA80935.1 - 8.1e-80 266.9 0.1 9.7e-80 266.6 0.1 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 EFA80935.1 - 0.014 15.4 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain Tim17 PF02466.19 EFA80936.1 - 1.8e-06 28.3 0.5 2.4e-06 27.9 0.5 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Form_Nir_trans PF01226.17 EFA80936.1 - 0.14 11.5 1.7 0.62 9.4 0.1 2.1 1 1 1 2 2 2 0 Formate/nitrite transporter Pkinase PF00069.25 EFA80937.1 - 3.2e-16 59.5 0.1 6.4e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80937.1 - 3.4e-09 36.4 0.3 1.7e-08 34.1 0.3 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase CLU PF13236.6 EFA80938.1 - 1.9e-46 158.7 0.2 1.1e-28 100.6 0.1 2.8 2 0 0 2 2 2 2 Clustered mitochondria Exo_endo_phos PF03372.23 EFA80938.1 - 4.1e-13 49.4 0.0 7.5e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 EFA80938.1 - 1.8e-10 41.2 10.1 0.012 16.5 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat eIF3_p135 PF12807.7 EFA80938.1 - 4.7e-10 39.8 0.1 4.7e-10 39.8 0.1 4.5 5 0 0 5 5 5 1 Translation initiation factor eIF3 subunit 135 ANAPC4_WD40 PF12894.7 EFA80938.1 - 1.3e-07 31.8 1.1 0.00012 22.3 0.8 3.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1077 PF06417.12 EFA80938.1 - 0.0027 17.7 1.5 0.015 15.3 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1077) Rer1 PF03248.13 EFA80939.1 - 6.2e-67 224.6 9.4 7.2e-67 224.4 9.4 1.0 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 EFA80939.1 - 0.016 14.8 3.2 0.016 14.8 3.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) DUF4131 PF13567.6 EFA80939.1 - 0.17 11.5 4.6 0.48 10.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF1980 PF09323.10 EFA80939.1 - 1.6 8.6 4.6 0.6 10.0 1.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) 2TM PF13239.6 EFA80939.1 - 5.7 7.3 8.6 8.7 6.7 0.6 2.3 2 0 0 2 2 2 0 2TM domain Syntaxin_2 PF14523.6 EFA80940.1 - 2.9e-13 50.0 6.1 2.9e-13 50.0 6.1 3.0 3 0 0 3 3 3 1 Syntaxin-like protein SNARE PF05739.19 EFA80940.1 - 4.4e-09 36.2 0.1 9.9e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Prominin PF05478.11 EFA80940.1 - 3.9e-05 21.9 3.2 0.052 11.5 0.1 2.1 2 0 0 2 2 2 2 Prominin GRP PF07172.11 EFA80940.1 - 0.0042 17.7 5.4 0.01 16.5 5.4 1.7 1 0 0 1 1 1 1 Glycine rich protein family PCRF PF03462.18 EFA80940.1 - 0.024 14.5 5.1 0.38 10.6 0.2 2.2 2 0 0 2 2 2 0 PCRF domain Syntaxin PF00804.25 EFA80940.1 - 0.17 11.5 6.6 0.063 12.9 0.7 2.4 2 0 0 2 2 2 0 Syntaxin COG2 PF06148.11 EFA80940.1 - 0.23 11.6 4.7 8.7 6.4 0.4 2.7 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 WD40 PF00400.32 EFA80941.1 - 2.2e-36 123.2 10.4 4.2e-06 27.4 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80941.1 - 1.8e-19 69.8 0.1 0.011 16.0 0.1 6.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFA80941.1 - 8.9e-06 24.5 0.0 0.00018 20.2 0.0 2.5 2 1 1 3 3 3 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EFA80941.1 - 1.2e-05 24.5 0.7 0.42 9.5 0.0 3.6 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFA80941.1 - 0.00071 19.5 1.8 0.086 12.7 0.2 3.5 2 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A CSTF1_dimer PF16699.5 EFA80941.1 - 0.0016 18.2 0.0 0.0035 17.1 0.0 1.6 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain SET PF00856.28 EFA80942.1 - 5.5e-16 59.4 0.0 1.4e-15 58.1 0.0 1.7 1 1 0 1 1 1 1 SET domain Ada_Zn_binding PF02805.16 EFA80942.1 - 0.16 12.0 0.3 0.16 12.0 0.3 2.6 3 0 0 3 3 3 0 Metal binding domain of Ada FNIP PF05725.12 EFA80943.1 - 6.9e-15 54.9 46.1 0.006 16.7 2.1 9.2 5 2 3 9 9 9 8 FNIP Repeat PUA_2 PF14306.6 EFA80943.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 PUA-like domain Choline_kinase PF01633.20 EFA80944.1 - 1.2e-57 195.0 0.5 1.8e-57 194.4 0.5 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFA80944.1 - 7.3e-07 29.4 0.0 8.7e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFA80944.1 - 0.019 13.9 0.2 0.028 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF5388 PF17363.2 EFA80945.1 - 0.084 13.1 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5388) WD40 PF00400.32 EFA80946.1 - 6.8e-16 58.4 11.7 2.7e-05 24.8 0.1 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA80946.1 - 7.3e-15 55.0 0.1 0.026 14.8 0.0 5.3 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA80946.1 - 1.5e-06 27.8 0.1 0.0012 18.2 0.0 2.6 2 1 0 2 2 2 2 WD40-like domain PQQ_3 PF13570.6 EFA80946.1 - 0.0033 17.9 0.0 3.6 8.2 0.0 3.8 3 0 0 3 3 3 1 PQQ-like domain FAM76 PF16046.5 EFA80947.1 - 0.0018 17.7 2.5 0.0021 17.5 2.5 1.0 1 0 0 1 1 1 1 FAM76 protein Salt_tol_Pase PF09506.10 EFA80947.1 - 0.044 12.6 0.0 0.05 12.4 0.0 1.1 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) MPS2 PF17060.5 EFA80947.1 - 0.49 9.6 5.7 0.76 9.0 3.5 2.1 1 1 0 2 2 2 0 Monopolar spindle protein 2 IBN_N PF03810.19 EFA80949.1 - 9.8e-12 44.6 0.0 3.6e-11 42.8 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cse1 PF08506.10 EFA80949.1 - 7.1e-11 41.5 1.4 7.1e-11 41.5 1.4 3.3 3 1 0 3 3 3 1 Cse1 Xpo1 PF08389.12 EFA80949.1 - 0.019 15.0 3.3 2.4 8.2 0.0 4.7 4 1 0 4 4 4 0 Exportin 1-like protein FANCI_S2 PF14676.6 EFA80949.1 - 0.021 15.1 0.2 6.1 7.1 0.0 3.0 2 0 0 2 2 2 0 FANCI solenoid 2 RAI16-like PF10257.9 EFA80949.1 - 0.038 12.9 0.2 0.098 11.5 0.2 1.7 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein PARG_cat PF05028.14 EFA80950.1 - 0.0043 16.4 0.2 0.0066 15.8 0.2 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF3446 PF11928.8 EFA80950.1 - 5.6 7.4 10.7 1.5 9.1 2.4 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain Piezo_RRas_bdg PF12166.8 EFA80951.1 - 0.073 12.4 0.0 0.073 12.4 0.0 1.0 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain LPG_synthase_TM PF03706.13 EFA80954.1 - 0.0087 15.6 2.5 0.021 14.3 0.0 2.3 2 1 0 2 2 2 1 Lysylphosphatidylglycerol synthase TM region Skp1_POZ PF03931.15 EFA80955.1 - 4.5e-05 23.5 0.2 0.054 13.7 0.0 2.6 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain Skp1 PF01466.19 EFA80955.1 - 0.00011 22.3 0.2 0.00034 20.7 0.0 2.0 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Macoilin PF09726.9 EFA80955.1 - 0.036 12.6 40.4 0.054 12.1 31.0 2.2 2 0 0 2 2 2 0 Macoilin family Menin PF05053.13 EFA80955.1 - 0.56 8.5 26.7 0.28 9.5 14.9 2.3 2 0 0 2 2 2 0 Menin Dapper PF15268.6 EFA80955.1 - 1.2 7.9 42.5 1.3 7.8 4.5 2.2 2 0 0 2 2 2 0 Dapper SOG2 PF10428.9 EFA80955.1 - 5.5 6.1 37.4 0.56 9.4 27.5 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein PAC3 PF10178.9 EFA80956.1 - 4.7e-22 77.9 0.1 7e-22 77.4 0.1 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 AbiEi_3 PF11459.8 EFA80956.1 - 0.11 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system EF-hand_1 PF00036.32 EFA80957.1 - 6.2e-24 81.7 12.0 4.5e-05 22.7 0.9 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFA80957.1 - 1.7e-20 73.2 8.6 3.8e-10 40.1 1.6 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA80957.1 - 6.8e-20 69.2 10.2 2.6e-05 23.8 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFA80957.1 - 1.4e-17 62.3 12.0 0.00013 21.3 0.7 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFA80957.1 - 7.8e-09 35.2 14.5 0.003 17.4 0.6 4.2 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA80957.1 - 2.5e-07 31.0 0.5 0.016 15.5 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFA80957.1 - 1.4e-06 28.2 6.4 0.043 13.8 0.3 3.7 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand RE_LlaJI PF09563.10 EFA80957.1 - 0.015 14.5 0.4 0.93 8.6 0.0 2.0 1 1 1 2 2 2 0 LlaJI restriction endonuclease DUF5580 PF17743.1 EFA80957.1 - 0.02 13.5 0.1 0.023 13.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Dockerin_1 PF00404.18 EFA80957.1 - 0.038 14.2 0.8 16 5.7 1.2 3.2 2 1 1 3 3 3 0 Dockerin type I domain EF-hand_9 PF14658.6 EFA80957.1 - 0.099 13.0 0.4 4 7.8 0.0 2.9 2 1 1 3 3 3 0 EF-hand domain Glyco_hydro_85 PF03644.13 EFA80958.1 - 6.2e-88 295.1 10.2 3.8e-87 292.5 6.4 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 85 CoA_binding PF02629.19 EFA80958.1 - 2.9e-25 88.8 0.3 7.2e-25 87.5 0.3 1.7 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 EFA80958.1 - 3.8e-21 75.5 0.1 6.7e-21 74.7 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase FBA PF04300.13 EFA80958.1 - 9.5e-19 67.8 0.0 2.1e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 F-box associated region Succ_CoA_lig PF13607.6 EFA80958.1 - 1.5e-08 34.5 0.0 3.6e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain La PF05383.17 EFA80959.1 - 2.6e-19 69.0 0.1 4.7e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFA80959.1 - 0.015 15.1 0.1 0.029 14.2 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 EFA80960.1 - 5.7e-37 126.8 0.1 5.7e-37 126.8 0.1 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFA80960.1 - 1.6e-15 57.4 0.0 1.6e-15 57.4 0.0 2.8 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA80960.1 - 0.0059 16.1 0.5 0.0096 15.4 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family Peptidase_S49_N PF08496.10 EFA80960.1 - 0.81 9.7 7.6 1.3 9.1 7.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4642 PF15484.6 EFA80960.1 - 5 7.3 14.3 2.3 8.4 11.6 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4642) FKBP_C PF00254.28 EFA80961.1 - 1.1e-27 96.1 0.1 1.5e-27 95.7 0.1 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase OAD_gamma PF04277.13 EFA80961.1 - 0.36 11.5 0.1 0.36 11.5 0.1 1.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Glyco_transf_5 PF08323.11 EFA80962.1 - 7.1e-36 124.1 0.0 1.5e-35 123.1 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EFA80962.1 - 9.2e-13 48.1 0.0 2.3e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA80962.1 - 1.1e-08 35.5 0.0 3.6e-08 33.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Alpha-amylase PF00128.24 EFA80962.1 - 0.00022 20.9 0.1 0.026 14.1 0.0 2.7 1 1 1 2 2 2 1 Alpha amylase, catalytic domain Glyco_transf_4 PF13439.6 EFA80962.1 - 0.0077 16.2 0.4 0.027 14.5 0.4 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EFA80962.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain DUF4411 PF14367.6 EFA80962.1 - 0.031 14.2 0.2 0.073 13.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Glyco_trans_1_2 PF13524.6 EFA80962.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 PP2C PF00481.21 EFA80963.1 - 8e-70 235.4 0.1 8e-70 235.4 0.1 4.2 4 2 1 6 6 6 1 Protein phosphatase 2C CH PF00307.31 EFA80963.1 - 4.5e-43 145.9 10.4 6.6e-14 52.0 0.1 5.8 5 0 0 5 5 5 5 Calponin homology (CH) domain G-alpha PF00503.20 EFA80963.1 - 9.7e-40 136.8 0.3 9.7e-40 136.8 0.3 3.7 3 2 0 3 3 3 1 G-protein alpha subunit PH PF00169.29 EFA80963.1 - 4.7e-16 59.2 2.2 9.9e-16 58.2 0.1 2.7 2 0 0 2 2 2 1 PH domain FERM_f0 PF16511.5 EFA80963.1 - 1.7e-12 47.5 0.1 2.7e-09 37.2 0.0 3.0 2 0 0 2 2 2 2 N-terminal or F0 domain of Talin-head FERM ERM PF00769.19 EFA80963.1 - 0.0014 18.5 28.4 0.0014 18.5 28.4 4.9 2 1 0 3 3 3 1 Ezrin/radixin/moesin family CAMSAP_CH PF11971.8 EFA80963.1 - 0.039 13.8 0.2 1.7 8.6 0.0 3.4 4 0 0 4 4 4 0 CAMSAP CH domain Pkinase PF00069.25 EFA80964.1 - 2.5e-65 220.5 0.5 5.2e-43 147.3 0.1 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA80964.1 - 7.7e-26 90.9 0.0 1.3e-20 73.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA80964.1 - 3.3e-05 23.4 0.0 0.00059 19.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFA80964.1 - 0.0018 18.3 0.1 0.0068 16.4 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA80964.1 - 0.05 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Prominin PF05478.11 EFA80964.1 - 0.052 11.5 6.7 0.1 10.6 6.7 1.4 1 0 0 1 1 1 0 Prominin OrsD PF12013.8 EFA80964.1 - 0.13 12.8 0.4 0.39 11.2 0.4 1.9 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D Transket_pyr PF02779.24 EFA80965.1 - 3.4e-39 134.4 0.0 5.1e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFA80965.1 - 6.1e-31 106.9 0.4 1.2e-30 105.9 0.4 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EFA80965.1 - 0.0088 16.3 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II DSPc PF00782.20 EFA80966.1 - 1.4e-34 118.8 0.2 3e-34 117.7 0.2 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EFA80966.1 - 7.4e-27 92.9 29.5 3.7e-09 36.2 5.3 5.1 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFA80966.1 - 7.6e-14 51.6 36.8 0.00017 21.9 2.1 6.7 4 2 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFA80966.1 - 1.1e-06 28.2 14.7 0.003 17.1 0.7 3.5 1 1 2 3 3 3 2 Leucine-rich repeat LRR_2 PF07723.13 EFA80966.1 - 0.015 16.0 0.1 15 6.4 0.0 4.2 3 0 0 3 3 3 0 Leucine Rich Repeat Y_phosphatase PF00102.27 EFA80966.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase LRR_1 PF00560.33 EFA80966.1 - 0.67 10.7 17.7 1.2e+02 3.9 0.1 8.0 8 0 0 8 8 8 0 Leucine Rich Repeat Rad17 PF03215.15 EFA80967.1 - 5.2e-22 78.7 0.2 5.2e-22 78.7 0.2 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 EFA80967.1 - 0.00022 21.5 0.0 0.0033 17.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFA80967.1 - 0.0028 17.4 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 EFA80967.1 - 0.0028 18.1 0.1 0.028 14.9 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EFA80967.1 - 0.0048 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFA80967.1 - 0.052 14.1 0.0 0.052 14.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EFA80967.1 - 0.065 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 EFA80967.1 - 0.25 11.4 3.3 0.36 10.9 0.0 2.8 2 1 1 3 3 3 0 AAA domain Bax1-I PF01027.20 EFA80968.1 - 3.4e-34 118.5 29.9 4.3e-34 118.2 29.9 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF1118 PF06549.12 EFA80968.1 - 0.0023 18.2 3.7 0.093 13.1 0.1 2.4 1 1 0 2 2 2 2 Protein of unknown function (DUF1118) SelK_SelG PF10961.8 EFA80968.1 - 0.26 11.9 1.4 11 6.7 0.4 2.5 2 0 0 2 2 2 0 Selenoprotein SelK_SelG Cys_Met_Meta_PP PF01053.20 EFA80969.1 - 6.3e-133 443.0 0.0 7.4e-133 442.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFA80969.1 - 1.6e-06 27.3 0.0 8.3e-06 25.0 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V AAA_7 PF12775.7 EFA80970.1 - 3.6e-08 33.1 0.5 0.42 10.1 0.0 5.0 4 0 0 4 4 4 3 P-loop containing dynein motor region AAA PF00004.29 EFA80970.1 - 1.1e-06 29.2 0.0 0.001 19.5 0.0 4.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFA80970.1 - 5.4e-06 26.7 0.0 0.59 10.4 0.0 5.4 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.6 EFA80970.1 - 0.00096 19.6 0.1 2.8 8.3 0.0 4.3 4 1 0 4 4 2 1 AAA ATPase domain Sigma54_activat PF00158.26 EFA80970.1 - 0.034 13.9 0.0 9.1 6.0 0.0 3.6 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF2996 PF11210.8 EFA80970.1 - 0.05 14.1 0.5 0.34 11.3 0.5 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2996) IstB_IS21 PF01695.17 EFA80970.1 - 0.064 13.0 0.0 10 5.8 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein zinc_ribbon_6 PF14599.6 EFA80970.1 - 0.067 13.2 0.5 0.37 10.8 0.1 2.5 2 0 0 2 2 2 0 Zinc-ribbon T2SSE PF00437.20 EFA80970.1 - 0.098 11.7 0.2 0.45 9.5 0.0 2.2 3 0 0 3 3 3 0 Type II/IV secretion system protein SoPB_HTH PF18090.1 EFA80970.1 - 0.13 12.4 0.0 7 6.9 0.0 2.9 2 0 0 2 2 2 0 Centromere-binding protein HTH domain AAA_5 PF07728.14 EFA80970.1 - 0.13 12.3 1.4 80 3.2 0.0 5.5 7 0 0 7 7 7 0 AAA domain (dynein-related subfamily) Peptidase_C92 PF05708.12 EFA80972.1 - 0.00013 22.1 0.0 0.0073 16.4 0.0 2.3 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Patatin PF01734.22 EFA80973.1 - 7.4e-09 36.1 0.2 7.4e-09 36.1 0.2 2.1 2 0 0 2 2 2 1 Patatin-like phospholipase WW PF00397.26 EFA80973.1 - 0.048 13.8 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 WW domain HABP4_PAI-RBP1 PF04774.15 EFA80974.1 - 0.00036 21.4 0.2 0.00044 21.1 0.2 1.2 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family BUD22 PF09073.10 EFA80975.1 - 0.66 9.3 123.3 0.033 13.6 88.2 3.6 1 1 1 2 2 2 0 BUD22 THP2 PF09432.10 EFA80976.1 - 0.096 12.7 2.1 0.57 10.3 0.1 2.8 2 1 1 3 3 3 0 Tho complex subunit THP2 Myc_N PF01056.18 EFA80977.1 - 0.043 13.7 3.7 0.064 13.1 3.7 1.3 1 0 0 1 1 1 0 Myc amino-terminal region DUF3682 PF12446.8 EFA80977.1 - 0.18 12.3 11.0 0.39 11.2 11.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF4820 PF16091.5 EFA80977.1 - 0.29 10.5 4.0 0.48 9.7 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Pho88 PF10032.9 EFA80977.1 - 0.55 9.5 2.5 2.8 7.2 0.2 2.5 3 0 0 3 3 3 0 Phosphate transport (Pho88) Cytomega_UL84 PF06284.11 EFA80977.1 - 0.94 7.9 2.3 1.4 7.3 2.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein WD40 PF00400.32 EFA80978.1 - 3.9e-27 93.9 17.9 6.9e-05 23.6 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat DUF1921 PF09081.10 EFA80978.1 - 0.11 12.8 0.0 13 6.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1921) Ank_2 PF12796.7 EFA80980.1 - 1.3e-36 125.1 16.7 2.8e-08 34.2 0.4 8.9 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA80980.1 - 2e-23 82.2 15.5 0.041 14.2 0.0 13.5 6 3 9 15 15 15 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA80980.1 - 8.4e-23 78.0 12.0 0.038 14.5 0.0 15.6 14 2 2 16 16 16 3 Ankyrin repeat Ank_4 PF13637.6 EFA80980.1 - 1.1e-20 73.7 15.4 0.0023 18.5 0.2 10.9 8 4 4 12 12 12 7 Ankyrin repeats (many copies) Ank PF00023.30 EFA80980.1 - 0.00012 22.3 12.3 0.34 11.4 0.1 8.6 11 1 1 12 12 12 1 Ankyrin repeat DUF249 PF03158.13 EFA80980.1 - 0.0002 21.1 7.2 2.1 8.0 3.5 4.9 2 1 2 4 4 4 2 Multigene family 530 protein RRM_5 PF13893.6 EFA80980.1 - 0.014 15.0 0.1 6.9 6.3 0.1 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PseudoU_synth_2 PF00849.22 EFA80981.1 - 4.3e-19 69.1 0.1 9.1e-19 68.1 0.1 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase BRO1 PF03097.18 EFA80981.1 - 1.2e-16 60.6 4.3 1.7e-16 60.0 4.3 1.2 1 0 0 1 1 1 1 BRO1-like domain FliS PF02561.14 EFA80981.1 - 0.48 10.7 4.2 0.37 11.1 0.8 2.6 3 0 0 3 3 3 0 Flagellar protein FliS Ribosomal_S3_C PF00189.20 EFA80983.1 - 2.1e-22 79.4 0.2 4.8e-22 78.3 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EFA80983.1 - 2.5e-10 40.0 0.6 3.9e-10 39.4 0.0 1.7 2 0 0 2 2 2 1 KH domain Coilin_N PF15862.5 EFA80983.1 - 0.12 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Coilin N-terminus PRELI PF04707.14 EFA80984.1 - 7.7e-29 100.5 0.8 1e-28 100.1 0.8 1.2 1 0 0 1 1 1 1 PRELI-like family DUF3378 PF11858.8 EFA80984.1 - 0.17 12.0 1.3 0.48 10.6 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3378) Ras PF00071.22 EFA80986.1 - 0.00014 21.5 0.3 0.46 10.1 0.0 2.9 2 1 0 2 2 2 2 Ras family Roc PF08477.13 EFA80986.1 - 0.071 13.3 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Flu_NS2 PF00601.19 EFA80986.1 - 3.4 8.0 7.1 0.55 10.6 0.6 2.7 3 0 0 3 3 3 0 Influenza non-structural protein (NS2) Chromo PF00385.24 EFA80987.1 - 0.00037 20.4 0.3 0.00079 19.3 0.3 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EFA80987.1 - 0.0004 20.6 0.1 0.0009 19.4 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Endotoxin_N PF03945.14 EFA80988.1 - 7e-12 45.5 9.8 1.1e-11 44.9 9.8 1.2 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Acid_PPase PF12689.7 EFA80988.1 - 0.013 15.3 0.2 0.031 14.1 0.2 1.6 1 0 0 1 1 1 0 Acid Phosphatase MutS_V PF00488.21 EFA80990.1 - 5.2e-76 254.9 0.2 1.6e-75 253.3 0.2 1.9 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFA80990.1 - 3.1e-39 135.2 0.6 3.1e-39 135.2 0.6 2.5 2 1 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EFA80990.1 - 9.4e-32 109.6 0.2 2.6e-31 108.2 0.2 1.8 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EFA80990.1 - 4.9e-15 56.0 2.0 9.1e-15 55.1 0.2 2.5 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EFA80990.1 - 1.5e-09 38.1 4.2 6.6e-09 36.0 3.9 2.4 2 0 0 2 2 2 1 MutS family domain IV Inp1 PF12634.7 EFA80990.1 - 0.0057 16.7 1.8 0.094 12.7 0.0 2.9 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 BTRD1 PF17660.1 EFA80990.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial tandem repeat domain 1 Cwf_Cwc_15 PF04889.12 EFA80990.1 - 9.7 5.8 28.5 0.52 10.0 15.2 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein VWA_2 PF13519.6 EFA80991.1 - 2.2e-11 44.4 0.0 9.2e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain UPF0524 PF15823.5 EFA80991.1 - 0.013 14.9 0.5 0.029 13.8 0.5 1.6 1 0 0 1 1 1 0 UPF0524 of C3orf70 Folliculin PF11704.8 EFA80991.1 - 0.11 12.4 1.9 0.27 11.1 1.9 1.6 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Hep_59 PF07052.11 EFA80991.1 - 0.17 12.7 5.3 0.58 10.9 5.3 1.9 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 Roughex PF06020.11 EFA80991.1 - 1.1 8.3 3.9 2 7.4 3.9 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DUF1940 PF09155.10 EFA80992.1 - 0.022 14.9 0.7 0.038 14.1 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) MRC1 PF09444.10 EFA80992.1 - 1.3 9.5 10.3 0.51 10.9 7.0 2.1 1 1 1 2 2 2 0 MRC1-like domain SOGA PF11365.8 EFA80993.1 - 0.015 16.4 2.3 0.015 16.4 2.3 2.7 2 0 0 2 2 2 0 Protein SOGA Fmp27_WPPW PF10359.9 EFA80993.1 - 0.02 13.8 13.6 0.033 13.0 13.6 1.5 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain V_ATPase_I PF01496.19 EFA80993.1 - 0.039 11.9 12.0 0.059 11.3 12.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PriC PF07445.12 EFA80993.1 - 0.11 12.4 6.4 0.087 12.7 4.4 1.8 1 1 1 2 2 2 0 Primosomal replication protein priC DUF4549 PF15082.6 EFA80993.1 - 0.15 11.8 2.3 0.16 11.8 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4549) DUF4407 PF14362.6 EFA80993.1 - 0.17 11.2 8.9 0.55 9.5 8.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 EFA80993.1 - 0.23 11.7 21.3 0.031 14.5 11.4 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) PA26 PF04636.13 EFA80993.1 - 0.78 8.6 9.0 1.2 7.9 9.0 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GWT1 PF06423.12 EFA80994.1 - 0.0087 16.2 1.4 0.0087 16.2 1.4 1.5 2 0 0 2 2 2 1 GWT1 Tetraspanin PF00335.20 EFA80994.1 - 0.089 12.5 10.6 0.031 14.0 6.0 2.0 2 0 0 2 2 2 0 Tetraspanin family DUF2418 PF10332.9 EFA80994.1 - 0.21 12.1 2.1 0.19 12.3 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) PDR_CDR PF06422.12 EFA80994.1 - 0.27 11.2 0.2 0.27 11.2 0.2 2.7 1 1 1 2 2 2 0 CDR ABC transporter DUF1129 PF06570.11 EFA80994.1 - 1.1 8.7 4.7 1.8 8.0 4.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2569 PF10754.9 EFA80994.1 - 1.3 9.4 10.9 0.28 11.6 5.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) SUR7 PF06687.12 EFA80994.1 - 3.7 7.1 19.6 0.95 9.0 12.7 2.3 1 1 1 2 2 2 0 SUR7/PalI family Ras PF00071.22 EFA80995.1 - 4.5e-59 198.7 0.1 5.4e-59 198.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA80995.1 - 7.7e-33 113.3 0.0 3.4e-32 111.2 0.0 1.8 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA80995.1 - 4.7e-10 39.2 0.1 5.6e-10 39.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA80995.1 - 0.00012 22.0 0.0 0.27 11.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFA80995.1 - 0.00029 20.3 0.0 0.00038 19.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA80995.1 - 0.0007 19.7 0.0 0.001 19.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA80995.1 - 0.002 17.7 0.0 0.0055 16.3 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EFA80995.1 - 0.0089 16.4 0.0 0.015 15.7 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 EFA80995.1 - 0.04 13.3 0.0 0.47 9.9 0.1 2.2 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EFA80995.1 - 0.15 11.4 0.0 0.32 10.4 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein DNA_pol_A_exo1 PF01612.20 EFA80996.1 - 5e-43 146.8 0.1 9.4e-43 145.9 0.1 1.5 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EFA80996.1 - 3.6e-19 69.3 0.6 3.6e-19 69.3 0.6 3.4 4 0 0 4 4 4 1 PMC2NT (NUC016) domain HRDC PF00570.23 EFA80996.1 - 5.9e-16 58.2 0.0 1.6e-15 56.9 0.0 1.8 1 0 0 1 1 1 1 HRDC domain Otopetrin PF03189.13 EFA80996.1 - 0.011 14.6 2.8 0.046 12.5 2.7 2.0 1 1 0 1 1 1 0 Otopetrin YL1 PF05764.13 EFA80996.1 - 0.021 14.9 28.8 0.017 15.2 13.4 2.4 2 0 0 2 2 2 0 YL1 nuclear protein TFIIA PF03153.13 EFA80996.1 - 1.7 8.6 97.4 0.013 15.6 51.6 2.5 2 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit FKBP_C PF00254.28 EFA80997.1 - 6.9e-33 112.9 0.4 3e-32 110.8 0.1 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EFA80997.1 - 1.8e-14 54.1 0.0 1.8e-14 54.1 0.0 2.3 2 1 0 2 2 1 1 Nucleoplasmin-like domain YL1 PF05764.13 EFA80997.1 - 1.4e-06 28.6 15.6 1.8e-06 28.2 15.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein SDA1 PF05285.12 EFA80997.1 - 0.022 14.2 15.0 0.029 13.8 15.0 1.1 1 0 0 1 1 1 0 SDA1 Pex14_N PF04695.13 EFA80997.1 - 0.048 14.3 6.1 0.07 13.8 6.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CDC45 PF02724.14 EFA80997.1 - 0.074 11.3 10.3 0.092 11.0 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFA80997.1 - 0.13 10.5 15.8 0.15 10.2 15.8 1.0 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.11 EFA80997.1 - 0.26 11.3 20.8 0.41 10.6 20.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) GREB1 PF15782.5 EFA80997.1 - 0.28 8.2 3.2 0.35 8.0 3.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 EFA80997.1 - 0.34 9.6 6.0 0.44 9.3 6.0 1.1 1 0 0 1 1 1 0 Presenilin Sin_N PF04801.13 EFA80997.1 - 0.5 9.5 8.2 0.61 9.2 8.2 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region FAM220 PF15487.6 EFA80997.1 - 1.4 8.5 4.9 1.8 8.1 4.9 1.1 1 0 0 1 1 1 0 FAM220 family Roughex PF06020.11 EFA80997.1 - 1.9 7.5 10.9 3 6.8 10.9 1.3 1 0 0 1 1 1 0 Drosophila roughex protein SAPS PF04499.15 EFA80997.1 - 4.1 6.1 6.4 5 5.8 6.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4589 PF15252.6 EFA80997.1 - 6.7 6.7 8.5 9.8 6.1 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) RRN3 PF05327.11 EFA80997.1 - 8.3 4.8 7.3 9.7 4.6 7.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ATP11 PF06644.11 EFA80997.1 - 9.1 6.0 11.5 13 5.5 11.5 1.1 1 0 0 1 1 1 0 ATP11 protein LRR_4 PF12799.7 EFA80998.1 - 0.097 13.1 21.4 3.8 8.1 0.3 7.1 6 2 1 7 7 7 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFA80998.1 - 0.17 11.8 1.6 0.26 11.2 0.3 2.0 2 0 0 2 2 2 0 F-box-like WD40 PF00400.32 EFA80999.1 - 5.6e-26 90.3 10.4 2.3e-05 25.0 0.0 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat Sof1 PF04158.14 EFA80999.1 - 4.5e-25 87.7 12.6 8.8e-25 86.8 12.6 1.5 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 EFA80999.1 - 6.8e-06 26.3 0.0 0.58 10.5 0.0 4.1 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA80999.1 - 0.02 13.8 0.0 0.81 8.6 0.0 2.3 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FNIP PF05725.12 EFA81000.1 - 1.5e-67 223.5 29.0 1.4e-14 54.0 0.5 8.1 5 2 4 9 9 9 8 FNIP Repeat Pkinase PF00069.25 EFA81000.1 - 5.9e-29 101.2 2.1 4e-28 98.5 2.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81000.1 - 2.4e-10 40.2 0.1 5.2e-07 29.2 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFA81000.1 - 0.00075 19.5 0.0 1.1 9.1 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Toxin_23 PF08093.11 EFA81001.1 - 0.052 13.7 1.8 0.1 12.7 0.1 2.3 2 0 0 2 2 2 0 Magi 5 toxic peptide family FNIP PF05725.12 EFA81002.1 - 2.4e-66 219.7 42.0 8.4e-15 54.7 0.1 10.4 6 3 3 9 9 9 8 FNIP Repeat Pkinase PF00069.25 EFA81002.1 - 7.2e-17 61.6 1.3 1.6e-15 57.2 1.3 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81002.1 - 1.2e-07 31.3 0.0 2.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RSS_P20 PF11757.8 EFA81002.1 - 0.11 13.0 2.6 0.13 12.7 0.5 2.2 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain PHO4 PF01384.20 EFA81003.1 - 1.8e-100 336.3 15.3 2.1e-100 336.0 15.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family XFP_N PF09364.10 EFA81004.1 - 0.013 14.4 0.4 0.026 13.3 0.1 1.6 2 0 0 2 2 2 0 XFP N-terminal domain ACP_syn_III PF08545.10 EFA81004.1 - 0.013 15.3 0.1 0.027 14.3 0.1 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EOS1 PF12326.8 EFA81004.1 - 0.056 13.4 0.2 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 N-glycosylation protein FNIP PF05725.12 EFA81005.1 - 1.9e-14 53.5 22.8 1.4e-06 28.4 0.1 8.1 10 0 0 10 10 10 4 FNIP Repeat SAPS PF04499.15 EFA81006.1 - 3.6e-08 32.6 0.3 3.6e-08 32.6 0.3 8.7 3 3 3 6 6 6 3 SIT4 phosphatase-associated protein RasGEF PF00617.19 EFA81007.1 - 5.5e-52 176.5 1.3 1.8e-51 174.9 1.3 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA81007.1 - 1.9e-18 66.6 1.4 1.9e-18 66.6 1.4 4.7 7 0 0 7 7 7 2 RasGEF N-terminal motif F-box-like PF12937.7 EFA81007.1 - 6.4e-12 45.2 8.6 3.4e-06 26.8 0.3 3.0 3 0 0 3 3 3 2 F-box-like F-box PF00646.33 EFA81007.1 - 6.8e-06 25.8 4.6 0.028 14.3 0.8 2.7 2 0 0 2 2 2 2 F-box domain TAtT PF16811.5 EFA81008.1 - 0.16 11.2 0.0 0.41 9.9 0.0 1.6 2 0 0 2 2 2 0 TRAP transporter T-component Tim17 PF02466.19 EFA81009.1 - 9.1e-12 45.3 2.5 1.2e-11 45.0 1.9 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2189 PF09955.9 EFA81009.1 - 0.017 15.3 0.9 1.8 8.8 0.4 2.4 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) TMEM135_C_rich PF15982.5 EFA81009.1 - 0.019 15.6 0.6 0.037 14.6 0.2 1.7 1 1 1 2 2 2 0 N-terminal cysteine-rich region of Transmembrane protein 135 Fer4_19 PF06902.11 EFA81009.1 - 0.06 13.4 0.2 0.13 12.3 0.2 1.6 1 0 0 1 1 1 0 Divergent 4Fe-4S mono-cluster adh_short PF00106.25 EFA81010.1 - 1.7e-40 138.5 0.0 2.7e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA81010.1 - 7.3e-24 84.6 0.0 1.2e-23 83.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Syntaxin-6_N PF09177.11 EFA81010.1 - 1.3e-22 80.2 0.7 1.3e-22 80.2 0.7 2.4 2 0 0 2 2 2 1 Syntaxin 6, N-terminal KR PF08659.10 EFA81010.1 - 5.3e-10 39.5 0.0 1.1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 KR domain SNARE PF05739.19 EFA81010.1 - 0.00025 21.0 0.3 0.00054 19.9 0.3 1.6 1 0 0 1 1 1 1 SNARE domain Ldh_1_N PF00056.23 EFA81010.1 - 0.023 14.8 0.1 0.051 13.7 0.1 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DUF4164 PF13747.6 EFA81010.1 - 0.039 14.2 3.0 0.19 12.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) DUF4739 PF15893.5 EFA81010.1 - 0.041 13.4 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4739) Use1 PF09753.9 EFA81010.1 - 0.044 13.5 8.0 0.18 11.5 7.8 1.7 1 1 1 2 2 2 0 Membrane fusion protein Use1 Phage_holin_2_1 PF04971.12 EFA81010.1 - 0.13 12.3 0.3 0.36 10.9 0.3 1.7 1 0 0 1 1 1 0 Bacteriophage P21 holin S 3HCDH_N PF02737.18 EFA81010.1 - 7.4 6.4 7.9 6.8 6.5 0.1 3.2 2 1 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DNA_repr_REX1B PF14966.6 EFA81011.1 - 1.4e-22 80.2 10.5 8.1e-18 64.9 1.2 3.1 3 0 0 3 3 3 2 DNA repair REX1-B DUF4407 PF14362.6 EFA81011.1 - 0.0012 18.3 3.7 0.0022 17.4 3.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF5082 PF16888.5 EFA81011.1 - 0.0048 17.2 16.2 0.11 12.8 11.2 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EFA81011.1 - 0.0085 16.1 5.1 0.28 11.2 0.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) PRD PF00874.20 EFA81011.1 - 0.023 15.0 5.5 0.53 10.6 0.4 2.7 2 0 0 2 2 2 0 PRD domain Baculo_PEP_C PF04513.12 EFA81011.1 - 0.1 12.7 6.4 1.2 9.1 0.4 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LRRFIP PF09738.9 EFA81011.1 - 0.11 11.9 5.3 0.23 10.9 5.3 1.4 1 1 0 1 1 1 0 LRRFIP family SMC_Nse1 PF07574.13 EFA81011.1 - 0.14 12.1 6.8 0.13 12.1 1.4 2.4 1 1 1 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex DASH_Dad3 PF08656.10 EFA81011.1 - 0.19 11.8 5.7 1.2 9.2 0.4 3.0 3 0 0 3 3 3 0 DASH complex subunit Dad3 DUF948 PF06103.11 EFA81011.1 - 0.21 11.9 1.9 2.7 8.3 0.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CdvA PF18822.1 EFA81011.1 - 0.24 11.2 5.2 5.8 6.8 0.1 2.7 2 1 0 2 2 2 0 CdvA-like coiled-coil domain LOH1CR12 PF10158.9 EFA81011.1 - 0.3 11.1 9.0 0.69 9.9 2.6 2.4 1 1 2 3 3 3 0 Tumour suppressor protein FliJ PF02050.16 EFA81011.1 - 0.33 11.2 6.3 18 5.6 0.3 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein Cob_adeno_trans PF01923.18 EFA81011.1 - 0.4 10.8 3.5 0.75 9.9 0.3 2.1 1 1 1 2 2 2 0 Cobalamin adenosyltransferase mCpol PF18182.1 EFA81011.1 - 0.47 10.8 2.8 0.88 9.9 0.4 2.3 2 1 0 2 2 2 0 minimal CRISPR polymerase domain PMC2NT PF08066.12 EFA81011.1 - 0.69 10.6 3.9 5 7.9 0.4 2.5 1 1 0 2 2 2 0 PMC2NT (NUC016) domain HIP1_clath_bdg PF16515.5 EFA81011.1 - 0.74 10.5 6.7 0.65 10.6 0.6 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0449 PF15136.6 EFA81011.1 - 1.3 9.5 8.2 0.71 10.4 4.8 2.2 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 Laminin_II PF06009.12 EFA81011.1 - 1.6 8.8 5.9 3.3 7.7 1.3 2.2 2 0 0 2 2 2 0 Laminin Domain II SOGA PF11365.8 EFA81011.1 - 1.8 9.7 6.5 2.6 9.3 4.6 2.1 1 1 0 1 1 1 0 Protein SOGA Ammonium_transp PF00909.21 EFA81012.1 - 2.2e-111 372.4 22.2 2.8e-111 372.0 22.2 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family UQ_con PF00179.26 EFA81012.1 - 2.3e-19 69.4 0.3 4.4e-19 68.5 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TMEM132D_C PF15706.5 EFA81012.1 - 0.094 12.5 0.1 0.32 10.8 0.1 1.9 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Smg8_Smg9 PF10220.9 EFA81013.1 - 8.4e-70 236.2 10.9 3e-60 204.6 8.4 3.1 2 1 0 3 3 3 2 Smg8_Smg9 Presenilin PF01080.17 EFA81015.1 - 2.5 6.8 7.0 3.1 6.4 0.1 2.2 2 0 0 2 2 2 0 Presenilin RasGEF PF00617.19 EFA81016.1 - 2.6e-38 132.0 0.3 1.9e-37 129.2 0.1 2.4 2 0 0 2 2 2 1 RasGEF domain Kelch_4 PF13418.6 EFA81016.1 - 6.2e-36 122.2 13.1 1.5e-09 37.7 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA81016.1 - 3.6e-35 119.3 3.1 3.3e-09 36.2 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 EFA81016.1 - 8.6e-35 118.2 7.0 1.6e-08 34.3 0.0 6.8 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFA81016.1 - 1e-29 101.8 15.4 3.6e-08 33.4 1.3 6.6 5 1 1 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFA81016.1 - 1.3e-28 98.7 19.5 2e-09 37.5 1.1 8.0 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA81016.1 - 1.7e-20 72.2 4.5 5.2e-05 23.0 0.0 6.6 6 0 0 6 6 6 4 Kelch motif RasGEF_N PF00618.20 EFA81016.1 - 2.1e-19 69.7 0.1 2.1e-19 69.7 0.1 2.8 2 0 0 2 2 2 1 RasGEF N-terminal motif PX PF00787.24 EFA81017.1 - 8e-14 51.6 1.2 8e-14 51.6 1.2 2.5 3 0 0 3 3 3 1 PX domain TFIIA PF03153.13 EFA81017.1 - 1.2e-05 25.5 105.4 0.0076 16.3 60.8 2.4 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Dynamin_N PF00350.23 EFA81017.1 - 2.7e-05 24.3 0.5 2.7e-05 24.3 0.5 6.0 3 3 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EFA81017.1 - 9.4e-05 22.5 0.2 0.0056 16.8 0.2 3.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.22 EFA81018.1 - 2.2e-09 37.0 0.1 5.3e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3439 PF11921.8 EFA81018.1 - 0.0049 16.8 1.4 0.0095 15.9 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) RRM_1 PF00076.22 EFA81019.1 - 7e-10 38.6 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ASD2 PF08687.11 EFA81019.1 - 0.049 13.2 7.4 0.092 12.3 7.4 1.5 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 DUF775 PF05603.12 EFA81019.1 - 0.11 12.0 5.7 0.2 11.1 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Arf PF00025.21 EFA81020.1 - 5.1e-36 123.8 0.0 5.9e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA81020.1 - 4.5e-10 39.8 0.0 1.2e-09 38.4 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA81020.1 - 1.9e-07 30.7 0.0 2.5e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA81020.1 - 8.2e-07 28.8 0.0 1.2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFA81020.1 - 2.4e-06 27.6 0.0 4.8e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFA81020.1 - 3.3e-05 23.4 0.0 4.1e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA81020.1 - 0.00012 21.3 0.2 0.0034 16.6 0.0 2.0 1 1 1 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.27 EFA81020.1 - 0.00044 19.9 0.0 0.21 11.1 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFA81020.1 - 0.0018 18.0 0.0 0.15 11.8 0.0 2.6 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EFA81020.1 - 0.0065 16.1 0.0 0.013 15.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 EFA81020.1 - 0.19 10.4 0.2 0.27 10.0 0.2 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class GRAM PF02893.20 EFA81021.1 - 2.1e-07 30.8 0.2 4e-07 29.9 0.1 1.6 1 1 0 1 1 1 1 GRAM domain Myotub-related PF06602.14 EFA81021.1 - 0.00033 19.7 0.1 0.00064 18.8 0.1 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain ADIP PF11559.8 EFA81022.1 - 0.00084 19.4 12.0 0.00084 19.4 12.0 4.3 2 1 2 4 4 4 2 Afadin- and alpha -actinin-Binding DASH_Spc19 PF08287.11 EFA81023.1 - 0.002 18.1 0.1 0.33 10.8 0.0 3.0 3 0 0 3 3 3 1 Spc19 FAP206 PF12018.8 EFA81023.1 - 0.0046 16.5 0.3 5.5 6.4 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function DUF2555 PF10742.9 EFA81023.1 - 0.01 15.7 0.0 20 5.1 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2555) Nup35_RRM PF05172.13 EFA81023.1 - 0.069 13.1 1.3 0.95 9.5 0.0 3.2 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif Sterile PF03015.19 EFA81023.1 - 0.13 12.5 9.7 0.66 10.2 0.0 4.7 5 1 1 6 6 6 0 Male sterility protein ERG2_Sigma1R PF04622.12 EFA81023.1 - 0.22 10.8 1.1 12 5.1 0.0 3.3 4 0 0 4 4 4 0 ERG2 and Sigma1 receptor like protein ABC_membrane PF00664.23 EFA81025.1 - 1.3e-51 175.9 26.2 1.3e-51 175.9 26.2 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region Peptidase_S8 PF00082.22 EFA81025.1 - 9e-49 166.3 7.4 9e-49 166.3 7.4 2.2 2 0 0 2 2 2 1 Subtilase family ABC_tran PF00005.27 EFA81025.1 - 1.4e-30 106.6 1.7 1.7e-30 106.3 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 EFA81025.1 - 0.00021 21.6 0.0 0.00078 19.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EFA81025.1 - 0.0014 18.1 16.5 0.0056 16.1 16.5 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA81025.1 - 0.022 14.6 4.1 2.7 7.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFA81025.1 - 0.087 13.2 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 EFA81025.1 - 0.3 10.7 26.3 0.28 10.9 0.0 2.4 1 1 1 2 2 2 0 AAA ATPase domain SLC12 PF03522.15 EFA81025.1 - 6.4 5.7 13.4 11 5.0 13.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Nop14 PF04147.12 EFA81025.1 - 9.4 4.3 21.7 13 3.8 21.7 1.1 1 0 0 1 1 1 0 Nop14-like family UCR_14kD PF02271.16 EFA81026.1 - 4.5e-20 71.5 0.2 5.3e-20 71.3 0.2 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Nucleolin_bd PF16725.5 EFA81026.1 - 0.068 12.8 0.4 6.7 6.4 0.0 3.0 3 0 0 3 3 3 0 Nucleolin binding domain Ank_4 PF13637.6 EFA81029.1 - 3.4e-12 46.6 5.7 0.0015 19.1 0.1 6.1 4 3 2 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81029.1 - 6.9e-11 42.6 1.3 0.022 15.3 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81029.1 - 2.7e-09 37.1 3.8 1.1 9.6 0.1 6.3 3 3 4 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81029.1 - 0.00022 21.4 0.0 11 7.0 0.0 5.7 6 0 0 6 6 6 1 Ankyrin repeat BLOC1_2 PF10046.9 EFA81030.1 - 5.1 7.5 15.0 2.1 8.7 6.1 3.9 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Takusan PF04822.13 EFA81030.1 - 7.6 6.5 20.2 0.049 13.5 5.5 4.0 3 0 0 3 3 3 0 Takusan Histone PF00125.24 EFA81031.1 - 9e-50 168.4 2.0 9e-50 168.4 2.0 11.0 6 3 1 9 9 9 1 Core histone H2A/H2B/H3/H4 SET PF00856.28 EFA81031.1 - 3.2e-22 79.7 0.1 3.2e-22 79.7 0.1 7.6 4 2 0 4 4 4 1 SET domain AWS PF17907.1 EFA81031.1 - 1.9e-11 43.8 8.0 4.9e-11 42.5 8.0 1.7 1 0 0 1 1 1 1 AWS domain CENP-T_C PF15511.6 EFA81031.1 - 0.00073 19.6 0.0 0.0021 18.2 0.0 1.7 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFA81031.1 - 0.0023 18.3 0.0 0.0064 16.8 0.0 1.8 1 0 0 1 1 1 1 CENP-S protein TILa PF12714.7 EFA81031.1 - 0.62 10.1 9.4 0.074 13.0 3.0 2.4 2 0 0 2 2 2 0 TILa domain DUF3580 PF12117.8 EFA81032.1 - 0.011 16.0 0.0 0.067 13.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3580) Voltage_CLC PF00654.20 EFA81033.1 - 1.2e-98 330.6 21.3 1.4e-98 330.4 21.3 1.0 1 0 0 1 1 1 1 Voltage gated chloride channel Inhibitor_I29 PF08246.12 EFA81034.1 - 1.5e-14 54.1 0.8 1.5e-14 54.1 0.8 2.0 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) DUF4771 PF15995.5 EFA81034.1 - 0.073 13.3 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) Peptidase_C1 PF00112.23 EFA81035.1 - 2.1e-31 109.7 0.0 2.8e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease CAP PF00188.26 EFA81035.1 - 5.5e-06 27.2 0.0 0.0084 16.9 0.0 2.6 1 1 1 2 2 2 2 Cysteine-rich secretory protein family MSA-2c PF12238.8 EFA81035.1 - 9.6 6.1 8.8 31 4.5 7.9 2.1 2 0 0 2 2 2 0 Merozoite surface antigen 2c HEAT PF02985.22 EFA81036.1 - 0.00012 22.1 2.5 6.5 7.3 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat RTP1_C1 PF10363.9 EFA81036.1 - 0.24 11.6 11.5 0.47 10.6 0.2 4.6 3 2 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Lipase_GDSL PF00657.22 EFA81037.1 - 1.5e-06 28.4 0.0 3e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Sdh_cyt PF01127.22 EFA81038.1 - 2.9e-20 72.5 0.3 3.9e-20 72.1 0.3 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1324 PF07038.11 EFA81038.1 - 0.083 13.1 0.3 0.21 11.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1324) F-box PF00646.33 EFA81039.1 - 0.00063 19.5 0.4 0.00063 19.5 0.4 2.6 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EFA81039.1 - 0.0046 16.8 1.1 0.013 15.3 0.4 2.1 2 0 0 2 2 2 1 F-box-like TrmB PF01978.19 EFA81039.1 - 0.13 12.2 0.0 5 7.1 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Macoilin PF09726.9 EFA81039.1 - 1.9 7.0 17.7 2.9 6.3 17.7 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EFA81039.1 - 2.6 6.7 9.2 3.9 6.2 9.2 1.2 1 0 0 1 1 1 0 Presenilin MMU163 PF17119.5 EFA81039.1 - 6.6 5.8 9.1 11 5.1 9.1 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis BRO1 PF03097.18 EFA81040.1 - 1.5e-56 191.9 9.0 9.6e-31 106.9 2.1 2.4 1 1 1 2 2 2 2 BRO1-like domain tRNA_U5-meth_tr PF05958.11 EFA81041.1 - 2.7e-17 62.8 0.0 5.2e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EFA81041.1 - 3.6e-08 33.3 0.4 1.2e-07 31.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA81041.1 - 3.6e-08 34.0 0.1 1.3e-07 32.2 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EFA81041.1 - 3.9e-06 26.6 0.5 2.1e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Ubie_methyltran PF01209.18 EFA81041.1 - 2.3e-05 23.9 0.1 5.4e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFA81041.1 - 7.3e-05 22.4 1.4 0.00014 21.4 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFA81041.1 - 0.00047 19.7 0.8 0.0048 16.4 0.0 2.5 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_11 PF08241.12 EFA81041.1 - 0.00053 20.6 0.1 0.0016 19.0 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EFA81041.1 - 0.00055 19.6 0.6 0.0012 18.5 0.1 1.8 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 EFA81041.1 - 0.0006 19.6 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EFA81041.1 - 0.0019 18.0 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA81041.1 - 0.0037 16.7 3.0 0.004 16.6 0.1 2.2 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 EFA81041.1 - 0.0054 16.5 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.6 EFA81041.1 - 0.012 15.6 0.0 0.012 15.6 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain MetW PF07021.12 EFA81041.1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RRM_1 PF00076.22 EFA81041.1 - 0.023 14.5 0.5 0.051 13.4 0.5 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_12 PF08242.12 EFA81041.1 - 0.085 13.6 7.4 0.096 13.4 0.1 3.1 3 0 0 3 3 2 0 Methyltransferase domain N6_N4_Mtase PF01555.18 EFA81041.1 - 0.15 11.8 5.2 0.15 11.7 0.0 2.7 3 1 0 3 3 3 0 DNA methylase DDHD PF02862.17 EFA81041.1 - 2.9 8.0 10.9 1.4 9.0 6.1 2.5 2 1 0 2 2 2 0 DDHD domain SET PF00856.28 EFA81042.1 - 1.7e-16 61.1 0.3 4.2e-16 59.8 0.1 1.8 2 0 0 2 2 2 1 SET domain TPR_8 PF13181.6 EFA81042.1 - 3.8e-05 23.6 0.3 0.00018 21.4 0.3 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81042.1 - 9.1e-05 22.3 3.7 0.0099 15.9 0.7 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA81042.1 - 0.03 14.1 6.6 0.055 13.3 1.5 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA81042.1 - 0.14 12.7 0.1 1.2 9.7 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Rpn3_C PF08375.11 EFA81043.1 - 2.8e-19 69.3 0.8 5.8e-19 68.3 0.8 1.5 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EFA81043.1 - 6.9e-19 68.3 5.3 1.1e-18 67.6 0.1 3.2 3 1 0 3 3 3 1 PCI domain TPR_2 PF07719.17 EFA81043.1 - 0.027 14.6 2.4 0.079 13.1 2.4 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat HEAT PF02985.22 EFA81043.1 - 0.11 12.8 0.0 0.4 11.1 0.0 1.9 1 0 0 1 1 1 0 HEAT repeat FLgD_tudor PF13861.6 EFA81043.1 - 0.29 11.4 0.9 3.1 8.1 0.4 2.4 2 0 0 2 2 2 0 FlgD Tudor-like domain TPR_12 PF13424.6 EFA81043.1 - 0.63 10.4 6.3 12 6.3 0.5 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Mucin PF01456.17 EFA81044.1 - 8.7 6.3 16.8 23 4.9 16.8 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein MMACHC PF16690.5 EFA81045.1 - 3.4e-08 33.4 0.2 5.3e-08 32.8 0.2 1.3 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family ECH_2 PF16113.5 EFA81046.1 - 4.1e-92 309.2 0.0 1.1e-91 307.8 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFA81046.1 - 4.5e-23 81.8 0.0 5.4e-21 75.0 0.0 2.3 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF1577 PF07614.11 EFA81046.1 - 0.067 12.3 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) Ank_2 PF12796.7 EFA81047.1 - 3.1e-23 82.1 24.5 2.8e-06 27.8 0.4 5.4 2 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81047.1 - 1.7e-19 69.9 3.5 0.00033 21.2 0.3 6.9 6 1 2 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81047.1 - 1.1e-14 54.3 7.8 0.23 11.8 0.2 8.8 4 1 4 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81047.1 - 4.9e-12 44.9 4.8 0.95 10.2 0.1 9.9 10 1 1 11 11 11 1 Ankyrin repeat Eapp_C PF10238.9 EFA81047.1 - 0.0021 18.2 11.6 0.0021 18.2 11.6 3.3 3 0 0 3 3 3 2 E2F-associated phosphoprotein DUF249 PF03158.13 EFA81047.1 - 0.012 15.3 3.9 0.26 11.0 1.5 3.5 2 1 2 4 4 4 0 Multigene family 530 protein WhiA_N PF10298.9 EFA81047.1 - 0.028 14.5 0.3 0.068 13.2 0.3 1.6 1 0 0 1 1 1 0 WhiA N-terminal LAGLIDADG-like domain zf-Di19 PF05605.12 EFA81047.1 - 0.072 13.4 0.6 0.25 11.7 0.1 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF4644 PF15486.6 EFA81047.1 - 1.8 8.3 4.9 4.7 6.9 4.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4644) RasGAP PF00616.19 EFA81048.1 - 8e-08 32.2 0.2 8e-08 32.2 0.2 3.0 3 1 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase LRR_6 PF13516.6 EFA81048.1 - 8.5e-06 25.4 28.9 0.068 13.2 0.1 8.6 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 EFA81048.1 - 0.13 12.9 14.6 28 5.8 0.0 7.3 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_4 PF12799.7 EFA81048.1 - 0.14 12.6 34.1 4.8 7.7 0.6 7.1 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) Germane PF10646.9 EFA81048.1 - 0.6 10.9 5.8 6 7.7 0.3 3.6 1 1 1 3 3 3 0 Sporulation and spore germination TIG PF01833.24 EFA81049.1 - 3.1e-62 206.6 99.1 6e-11 42.3 5.7 14.3 12 2 2 14 14 14 11 IPT/TIG domain DNase_II PF03265.15 EFA81049.1 - 4.8e-27 95.1 14.4 6.9e-19 68.3 0.6 3.9 3 1 0 3 3 3 2 Deoxyribonuclease II RRM_1 PF00076.22 EFA81049.1 - 5e-17 61.5 0.2 4.6e-16 58.4 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lipase_GDSL PF00657.22 EFA81049.1 - 6.7e-06 26.2 0.1 0.00014 22.0 0.1 2.7 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase DASH_Duo1 PF08651.10 EFA81049.1 - 0.13 12.0 0.4 0.52 10.1 0.4 2.0 1 0 0 1 1 1 0 DASH complex subunit Duo1 Dicty_REP PF05086.12 EFA81049.1 - 5.5 4.8 25.5 9.3 4.1 25.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SNARE PF05739.19 EFA81050.1 - 0.00013 21.9 2.5 0.00013 21.9 2.5 2.9 3 0 0 3 3 3 1 SNARE domain Sec20 PF03908.13 EFA81050.1 - 0.00048 20.0 6.9 0.00081 19.3 2.1 2.7 2 1 0 2 2 2 1 Sec20 V-SNARE_C PF12352.8 EFA81050.1 - 0.0019 18.5 3.2 0.0027 18.0 1.8 2.0 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus LMBR1 PF04791.16 EFA81050.1 - 0.0023 17.0 3.2 0.0028 16.6 3.2 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF3533 PF12051.8 EFA81050.1 - 0.019 13.9 2.8 0.032 13.2 2.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3533) MtrF PF09472.10 EFA81050.1 - 0.023 14.1 0.5 0.045 13.2 0.5 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) FeoB_associated PF12669.7 EFA81050.1 - 0.041 14.3 0.9 0.067 13.6 0.9 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF948 PF06103.11 EFA81050.1 - 0.29 11.4 7.6 0.43 10.9 0.0 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Vpu PF00558.19 EFA81050.1 - 0.84 9.5 7.0 0.11 12.3 2.1 2.0 2 0 0 2 2 2 0 Vpu protein Orf78 PF06024.12 EFA81050.1 - 2.3 8.6 6.4 5.3 7.4 4.5 2.4 1 1 0 2 2 2 0 Orf78 (ac78) DUF4407 PF14362.6 EFA81050.1 - 2.3 7.5 14.8 3.2 7.0 14.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 EFA81050.1 - 2.8 5.8 9.5 0.3 9.0 3.5 1.9 2 0 0 2 2 2 0 Prominin V-SNARE PF05008.15 EFA81050.1 - 2.9 8.3 13.2 0.73 10.2 4.7 2.8 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus XhlA PF10779.9 EFA81050.1 - 4.4 7.6 10.1 0.93 9.7 1.0 3.2 3 1 1 4 4 4 0 Haemolysin XhlA DUF4140 PF13600.6 EFA81050.1 - 8.4 6.9 14.1 0.56 10.7 1.4 3.3 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF4199 PF13858.6 EFA81050.1 - 8.8 6.7 7.8 2.2 8.7 3.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) PCI PF01399.27 EFA81053.1 - 2.3e-09 37.7 0.4 2.3e-09 37.7 0.4 2.2 2 0 0 2 2 2 1 PCI domain DUF2564 PF10819.8 EFA81053.1 - 0.03 14.7 0.0 0.11 12.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) DUF4298 PF14131.6 EFA81053.1 - 0.11 12.5 2.2 0.24 11.4 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) SOAR PF16533.5 EFA81053.1 - 1.1 9.3 3.8 0.97 9.4 0.3 2.5 3 0 0 3 3 3 0 STIM1 Orai1-activating region DUF1462 PF07315.11 EFA81054.1 - 0.11 12.7 0.2 0.86 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1462) Vps52 PF04129.12 EFA81055.1 - 8.1e-80 269.0 35.2 1.1e-79 268.5 35.2 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family BSD PF03909.17 EFA81055.1 - 0.029 14.4 0.8 0.68 10.0 0.3 2.9 2 0 0 2 2 2 0 BSD domain Sec3_C PF09763.9 EFA81055.1 - 0.067 11.6 35.9 7.4 4.8 35.9 3.1 1 1 0 1 1 1 0 Exocyst complex component Sec3 AAA PF00004.29 EFA81057.1 - 3.1e-31 108.5 0.4 9.4e-31 107.0 0.0 2.0 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFA81057.1 - 1.1e-06 29.2 0.0 3.5e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA81057.1 - 1.7e-06 28.4 0.1 1.8e-05 25.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFA81057.1 - 6.4e-05 23.0 0.3 0.00015 21.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EFA81057.1 - 9.7e-05 22.0 0.0 0.015 14.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA81057.1 - 0.00011 22.6 0.1 0.00037 20.9 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFA81057.1 - 0.00042 20.1 0.0 0.0013 18.5 0.0 1.7 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 EFA81057.1 - 0.00043 20.2 0.1 0.0015 18.5 0.1 1.8 1 1 0 1 1 1 1 NACHT domain AAA_2 PF07724.14 EFA81057.1 - 0.00076 19.6 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EFA81057.1 - 0.0015 18.1 0.0 0.0029 17.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 EFA81057.1 - 0.0016 18.3 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EFA81057.1 - 0.002 18.1 0.0 0.0047 16.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EFA81057.1 - 0.0022 17.2 0.0 0.0047 16.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 EFA81057.1 - 0.0032 17.7 0.0 0.0051 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFA81057.1 - 0.0036 17.0 0.1 0.013 15.2 0.0 1.8 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EFA81057.1 - 0.0037 17.0 0.0 0.007 16.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ABC_tran PF00005.27 EFA81057.1 - 0.0043 17.6 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ATPase_2 PF01637.18 EFA81057.1 - 0.0044 17.0 0.8 1.8 8.5 0.2 2.4 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea DnaB_C PF03796.15 EFA81057.1 - 0.0048 16.3 0.0 0.0086 15.4 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_30 PF13604.6 EFA81057.1 - 0.0052 16.5 0.0 0.0099 15.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EFA81057.1 - 0.0055 16.7 0.3 0.088 12.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EFA81057.1 - 0.0058 17.0 0.0 0.019 15.4 0.0 1.9 2 0 0 2 2 1 1 RNA helicase Rad17 PF03215.15 EFA81057.1 - 0.0066 16.4 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 EFA81057.1 - 0.0069 16.4 0.1 0.019 15.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 EFA81057.1 - 0.0096 15.2 0.6 2.9 7.1 0.0 2.5 1 1 1 2 2 2 1 KAP family P-loop domain TIP49 PF06068.13 EFA81057.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Cytidylate_kin PF02224.18 EFA81057.1 - 0.015 15.1 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_19 PF13245.6 EFA81057.1 - 0.017 15.5 0.6 0.088 13.1 0.6 2.1 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EFA81057.1 - 0.017 14.5 0.6 0.26 10.6 0.1 2.2 1 1 1 2 2 2 0 KaiC DUF2075 PF09848.9 EFA81057.1 - 0.025 13.8 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 EFA81057.1 - 0.031 14.7 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFA81057.1 - 0.032 13.3 0.1 0.055 12.5 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 EFA81057.1 - 0.043 13.3 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Viral_helicase1 PF01443.18 EFA81057.1 - 0.052 13.3 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EFA81057.1 - 0.057 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.9 EFA81057.1 - 0.062 13.0 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation CPT PF07931.12 EFA81057.1 - 0.067 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EFA81057.1 - 0.08 13.1 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFA81057.1 - 0.1 11.9 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_3 PF07726.11 EFA81057.1 - 0.15 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) eIF-3c_N PF05470.12 EFA81058.1 - 1.4e-133 446.4 25.0 9.1e-131 437.1 25.0 2.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EFA81058.1 - 6.5e-10 39.5 0.1 7.6e-09 36.0 0.0 2.6 2 0 0 2 2 2 1 PCI domain DUF4186 PF13811.6 EFA81058.1 - 0.039 14.0 0.2 0.21 11.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) Sigma70_r4 PF04545.16 EFA81058.1 - 0.095 12.2 0.3 0.61 9.7 0.0 2.4 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_IclR PF09339.10 EFA81058.1 - 0.15 11.9 0.0 0.45 10.4 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain MADF_DNA_bdg PF10545.9 EFA81058.1 - 1.8 9.0 5.2 29 5.0 0.1 4.0 5 0 0 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like FAM25 PF15825.5 EFA81058.1 - 2.1 8.7 4.8 6.1 7.3 4.8 1.7 1 0 0 1 1 1 0 FAM25 family Lipoxygenase PF00305.19 EFA81059.1 - 1.4e-59 202.2 1.0 1.9e-59 201.8 1.0 1.1 1 0 0 1 1 1 1 Lipoxygenase COPIIcoated_ERV PF07970.12 EFA81060.1 - 5.1e-24 85.4 0.9 2.1e-13 50.6 0.3 2.3 1 1 1 2 2 2 2 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFA81060.1 - 1.1e-20 73.7 0.2 2.2e-20 72.8 0.2 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CorA PF01544.18 EFA81061.1 - 6.8e-10 38.7 0.3 1.1e-09 38.0 0.1 1.4 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein MerR-DNA-bind PF09278.11 EFA81061.1 - 0.11 13.0 0.6 0.35 11.4 0.1 1.8 2 0 0 2 2 2 0 MerR, DNA binding Pkinase PF00069.25 EFA81063.1 - 4.3e-66 223.0 0.0 4.3e-66 223.0 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81063.1 - 2.2e-28 99.3 0.0 2.2e-28 99.3 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase AP-5_subunit_s1 PF15001.6 EFA81063.1 - 0.00041 20.4 11.3 0.00041 20.4 11.3 2.3 2 0 0 2 2 2 1 AP-5 complex subunit sigma-1 EPL1 PF10513.9 EFA81063.1 - 0.0007 20.0 8.4 0.0007 20.0 8.4 2.4 2 0 0 2 2 2 1 Enhancer of polycomb-like Velvet PF11754.8 EFA81063.1 - 0.0008 19.4 15.3 0.00092 19.2 3.8 2.3 2 0 0 2 2 2 1 Velvet factor DDHD PF02862.17 EFA81063.1 - 0.0012 19.1 5.2 0.0012 19.1 5.2 2.2 2 0 0 2 2 2 1 DDHD domain SLC12 PF03522.15 EFA81063.1 - 0.08 12.0 27.9 0.0093 15.0 12.1 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Dynamin_N PF00350.23 EFA81063.1 - 0.14 12.2 7.8 0.42 10.7 3.3 2.3 2 0 0 2 2 2 0 Dynamin family MMR1 PF08505.10 EFA81063.1 - 0.17 12.2 41.0 0.024 14.9 16.5 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Neur_chan_memb PF02932.16 EFA81063.1 - 0.64 10.0 19.8 1.4 9.0 11.0 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 EFA81063.1 - 1.2 8.5 30.0 0.017 14.6 12.2 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Pex14_N PF04695.13 EFA81063.1 - 1.4 9.6 44.0 0.1 13.2 21.8 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 EFA81063.1 - 1.5 7.5 39.2 0.49 9.1 19.9 2.1 2 0 0 2 2 2 0 Presenilin SET PF00856.28 EFA81063.1 - 2.7 8.4 11.4 0.11 12.8 0.4 2.4 2 1 0 2 2 2 0 SET domain DUF4407 PF14362.6 EFA81063.1 - 4.1 6.7 30.9 0.07 12.5 13.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF5308 PF17233.2 EFA81063.1 - 4.1 7.6 25.5 0.062 13.5 8.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5308) TFIIA PF03153.13 EFA81063.1 - 4.8 7.1 80.3 6.3 6.7 23.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spore_coat_CotO PF14153.6 EFA81063.1 - 4.9 7.1 37.4 0.035 14.0 15.4 2.3 2 0 0 2 2 2 0 Spore coat protein CotO EOS1 PF12326.8 EFA81063.1 - 6.7 6.6 14.5 11 5.8 0.0 2.3 2 0 0 2 2 2 0 N-glycosylation protein PepSY_TM PF03929.16 EFA81063.1 - 9.4 5.8 15.2 0.24 11.0 4.1 2.3 2 0 0 2 2 2 0 PepSY-associated TM region MAT1 PF06391.13 EFA81063.1 - 9.8 5.9 39.8 0.58 9.9 18.0 2.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Paramecium_SA PF01508.16 EFA81064.1 - 0.084 13.3 8.4 1.7 9.1 0.9 2.2 2 0 0 2 2 2 0 Paramecium surface antigen domain HEAT PF02985.22 EFA81065.1 - 2.8e-06 27.1 4.1 0.042 14.1 0.1 4.6 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EFA81065.1 - 0.011 16.1 0.3 0.31 11.5 0.1 3.0 2 1 1 3 3 3 0 HEAT repeats Vac14_Fab1_bd PF12755.7 EFA81065.1 - 0.012 16.2 0.2 0.12 13.0 0.1 2.9 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Spt46 PF17734.1 EFA81065.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 46 ParcG PF10274.9 EFA81065.1 - 0.084 13.0 2.5 0.097 12.8 0.3 2.2 2 1 0 2 2 2 0 Parkin co-regulated protein DUF2175 PF09943.9 EFA81065.1 - 0.24 11.7 2.0 0.57 10.5 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) EGF_2 PF07974.13 EFA81066.1 - 0.0034 17.7 12.1 0.0074 16.6 12.1 1.6 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA81066.1 - 0.084 13.2 4.2 0.2 12.0 4.2 1.6 1 0 0 1 1 1 0 EB module I-EGF_1 PF18372.1 EFA81066.1 - 0.089 12.9 5.3 0.19 11.9 5.3 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 Conotoxin_I2 PF17557.2 EFA81067.1 - 0.0095 16.0 6.5 0.018 15.2 6.5 1.5 1 1 0 1 1 1 1 I2-superfamily conotoxins UPF0506 PF11703.8 EFA81067.1 - 0.026 14.9 9.3 0.038 14.4 9.3 1.4 1 1 0 1 1 1 0 UPF0506 Toxin_18 PF08087.11 EFA81067.1 - 0.035 14.1 8.6 0.082 12.9 8.6 1.8 1 1 0 1 1 1 0 Conotoxin O-superfamily Conotoxin PF02950.17 EFA81067.1 - 0.068 14.2 6.6 0.068 14.2 6.6 1.4 1 1 0 1 1 1 0 Conotoxin Toxin_19 PF08088.12 EFA81067.1 - 0.25 11.5 8.7 0.46 10.7 8.7 1.4 1 0 0 1 1 1 0 Conotoxin I-superfamily Ribosomal_L7Ae PF01248.26 EFA81068.1 - 2.5e-05 23.9 0.0 8.1e-05 22.3 0.0 1.9 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family TFIIA PF03153.13 EFA81068.1 - 3.3 7.6 76.7 0.57 10.1 25.2 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Proteasome PF00227.26 EFA81069.1 - 5.9e-55 185.7 0.1 7.5e-55 185.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA81069.1 - 5.5e-13 48.3 0.1 1e-12 47.5 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature WD40 PF00400.32 EFA81070.1 - 1.4e-05 25.8 5.6 0.013 16.3 0.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat BBS1 PF14779.6 EFA81070.1 - 0.093 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 RhoGAP PF00620.27 EFA81071.1 - 2e-07 31.0 0.0 2.4e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain WD40 PF00400.32 EFA81072.1 - 1.2e-31 108.2 28.2 5.6e-06 27.0 0.5 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat zf-RING_UBOX PF13445.6 EFA81072.1 - 1.8e-08 34.3 4.4 7.2e-08 32.3 4.4 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFA81072.1 - 3.9e-06 26.9 1.8 1.4e-05 25.1 1.8 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFA81072.1 - 5.9e-06 26.0 2.1 5.9e-06 26.0 2.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PQQ_3 PF13570.6 EFA81072.1 - 1.6e-05 25.3 12.4 2.1 9.0 0.0 6.5 6 1 1 7 7 7 2 PQQ-like domain zf-Nse PF11789.8 EFA81072.1 - 2.2e-05 24.2 1.5 6.6e-05 22.6 1.5 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 EFA81072.1 - 2.3e-05 24.2 1.3 8.6e-05 22.4 1.3 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA81072.1 - 8.6e-05 22.3 2.6 8.6e-05 22.3 2.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Nup160 PF11715.8 EFA81072.1 - 0.00019 20.2 9.7 0.024 13.3 0.1 4.8 4 1 0 6 6 6 2 Nucleoporin Nup120/160 U-box PF04564.15 EFA81072.1 - 0.00022 21.4 0.0 0.00064 19.8 0.0 1.8 1 0 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.6 EFA81072.1 - 0.00062 19.6 2.8 0.00062 19.6 2.8 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFA81072.1 - 0.0026 18.0 3.5 0.0026 18.0 3.5 2.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFA81072.1 - 0.0039 17.0 1.1 0.0039 17.0 1.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Sec3-PIP2_bind PF15277.6 EFA81072.1 - 0.092 12.9 0.0 1.1 9.4 0.0 2.8 3 1 0 3 3 3 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH zf-RING_10 PF16685.5 EFA81072.1 - 0.093 12.9 0.2 0.093 12.9 0.2 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Sina PF03145.16 EFA81072.1 - 8.3 6.3 9.3 0.062 13.2 0.9 1.7 2 0 0 2 2 1 0 Seven in absentia protein family zf-CRD PF17979.1 EFA81073.1 - 1.6e-33 116.1 5.8 1.6e-33 116.1 5.8 3.4 2 1 1 3 3 3 1 Cysteine rich domain with multizinc binding regions FHA PF00498.26 EFA81073.1 - 6e-08 32.9 0.9 1.6e-07 31.6 0.1 2.1 2 0 0 2 2 2 1 FHA domain zf-C3HC4_3 PF13920.6 EFA81073.1 - 2.7e-05 23.9 13.5 2.7e-05 23.9 13.5 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-CCHH PF10283.9 EFA81073.1 - 5.8e-05 23.0 4.9 0.00023 21.1 4.9 2.1 1 0 0 1 1 1 1 PBZ domain zf-C3HC4_2 PF13923.6 EFA81073.1 - 0.00065 19.5 16.8 0.00065 19.5 16.8 3.7 4 1 1 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA81073.1 - 0.00096 19.4 17.3 0.00096 19.4 17.3 3.6 3 1 0 3 3 2 1 Ring finger domain Yop-YscD_cpl PF16697.5 EFA81073.1 - 0.0014 18.9 0.0 0.0037 17.6 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain CENP-B_dimeris PF09026.10 EFA81073.1 - 0.0016 18.8 5.2 0.016 15.6 5.0 2.5 2 0 0 2 2 2 1 Centromere protein B dimerisation domain zf-C3HC4 PF00097.25 EFA81073.1 - 0.012 15.5 18.0 0.012 15.5 18.0 3.8 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFA81073.1 - 0.21 11.5 6.9 0.67 9.9 6.9 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Ndc1_Nup PF09531.10 EFA81073.1 - 2.2 6.8 6.3 2.9 6.5 6.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-C2H2_jaz PF12171.8 EFA81074.1 - 3.3e-06 27.2 3.4 7.1e-06 26.2 3.4 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFA81074.1 - 0.00077 19.8 2.8 0.0014 18.9 2.8 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Folate_carrier PF01770.18 EFA81075.1 - 9.2e-39 133.3 22.8 9e-26 90.6 11.6 2.1 1 1 1 2 2 2 2 Reduced folate carrier S-antigen PF05756.11 EFA81075.1 - 0.13 12.7 0.2 0.32 11.4 0.2 1.6 1 0 0 1 1 1 0 S-antigen protein LapA_dom PF06305.11 EFA81075.1 - 7.8 6.4 10.5 3.7 7.4 1.6 3.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Ribosomal_L18 PF17135.4 EFA81076.1 - 1.8e-74 249.2 4.8 2e-74 249.0 4.8 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EFA81076.1 - 0.0093 16.6 1.1 0.017 15.8 1.1 1.5 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A TMEM18 PF14770.6 EFA81077.1 - 0.022 14.8 0.7 0.043 13.8 0.7 1.4 1 0 0 1 1 1 0 Transmembrane protein 18 EF-hand_1 PF00036.32 EFA81078.1 - 9.6e-41 134.3 12.3 2.6e-09 36.0 0.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFA81078.1 - 1.2e-36 125.0 2.3 9.4e-19 67.6 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA81078.1 - 1.7e-32 111.0 10.8 4.9e-15 55.1 0.5 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EFA81078.1 - 3.9e-30 101.2 7.6 2.9e-09 36.1 0.1 4.5 4 2 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFA81078.1 - 1.6e-26 90.6 10.9 1.2e-06 27.7 0.0 4.4 4 1 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EFA81078.1 - 4.5e-15 55.7 0.1 3.9e-09 36.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFA81078.1 - 2e-09 37.3 0.8 0.00019 21.4 0.2 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFA81078.1 - 5.2e-09 36.4 0.1 0.00065 20.0 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EFA81078.1 - 9.9e-07 28.7 0.4 0.045 13.8 0.0 3.1 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 EFA81078.1 - 0.00014 22.0 2.4 0.16 12.1 0.1 3.2 1 1 2 3 3 3 2 Dockerin type I domain DUF1103 PF06513.11 EFA81078.1 - 0.00037 20.2 3.5 0.00044 19.9 3.5 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) EFhand_Ca_insen PF08726.10 EFA81078.1 - 0.00068 19.7 0.6 0.0032 17.5 0.1 2.2 2 2 0 2 2 2 1 Ca2+ insensitive EF hand DUF3349 PF11829.8 EFA81078.1 - 0.001 19.8 0.5 1.3 9.9 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 EFA81078.1 - 0.0012 18.9 1.5 0.71 9.8 0.0 3.6 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 EFA81078.1 - 0.0019 18.6 1.2 1.3 9.4 0.1 2.8 2 1 1 3 3 3 1 RNA polymerase Rpb4 DUF5580 PF17743.1 EFA81078.1 - 0.0029 16.2 0.0 0.0029 16.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Poly_export PF02563.16 EFA81078.1 - 0.0084 16.3 0.0 0.17 12.1 0.0 2.6 2 1 1 3 3 3 1 Polysaccharide biosynthesis/export protein EF-hand_11 PF08976.11 EFA81078.1 - 0.0097 16.8 0.0 1.8 9.5 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EFA81078.1 - 0.01 15.8 0.4 0.51 10.3 0.1 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB Spore_III_AB PF09548.10 EFA81078.1 - 0.021 15.0 1.1 0.039 14.1 1.1 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) SapB_1 PF05184.15 EFA81078.1 - 0.026 14.5 6.0 1.8 8.7 0.1 3.7 4 0 0 4 4 4 0 Saposin-like type B, region 1 dCache_2 PF08269.11 EFA81078.1 - 0.032 13.4 0.1 1.2 8.3 0.1 2.2 1 1 1 2 2 2 0 Cache domain MotA_activ PF09114.10 EFA81078.1 - 0.036 14.2 0.3 0.48 10.6 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF4497 PF14924.6 EFA81078.1 - 0.042 14.3 0.0 12 6.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4497) TetR_C_7 PF14246.6 EFA81078.1 - 0.071 13.1 0.1 7.4 6.6 0.0 2.7 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain RloB PF13707.6 EFA81078.1 - 0.11 12.7 0.3 0.6 10.3 0.3 2.0 1 1 0 1 1 1 0 RloB-like protein SurA_N_2 PF13623.6 EFA81078.1 - 0.12 12.3 1.7 2.5 7.9 0.5 2.2 1 1 1 2 2 2 0 SurA N-terminal domain MBOAT PF03062.19 EFA81079.1 - 9.9e-11 41.6 10.8 1.3e-10 41.2 9.5 1.8 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family REC114-like PF15165.6 EFA81079.1 - 0.48 10.2 5.6 0.77 9.5 5.6 1.2 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like WD40 PF00400.32 EFA81080.1 - 2.8e-33 113.4 41.0 1.7e-06 28.6 0.9 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA81080.1 - 9.7e-09 35.4 6.2 0.53 10.6 0.1 6.0 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 EFA81080.1 - 4.4e-05 23.3 0.0 8.4e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like WD40_like PF17005.5 EFA81080.1 - 0.00019 20.9 0.1 0.022 14.1 0.0 3.4 1 1 1 3 3 3 2 WD40-like domain F-box_4 PF15966.5 EFA81080.1 - 0.00022 21.1 0.0 0.021 14.7 0.0 3.0 3 0 0 3 3 3 1 F-box F-box PF00646.33 EFA81080.1 - 0.0003 20.6 0.0 0.00072 19.4 0.0 1.7 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 EFA81080.1 - 0.0034 17.0 2.0 0.041 13.5 1.7 2.4 1 1 0 1 1 1 1 PQQ-like domain FA_hydroxylase PF04116.13 EFA81081.1 - 2.6e-11 44.0 7.5 2.6e-11 44.0 7.5 3.4 4 1 0 4 4 4 2 Fatty acid hydroxylase superfamily Syntaxin-18_N PF10496.9 EFA81082.1 - 5.3e-10 39.4 13.1 5.3e-10 39.4 13.1 4.1 2 2 1 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus Ribosomal_S13_N PF08069.12 EFA81083.1 - 1.2e-28 98.9 0.2 2.7e-28 97.8 0.2 1.6 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EFA81083.1 - 8.5e-11 41.9 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 HicB PF05534.12 EFA81083.1 - 0.047 13.5 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 HicB family YflT PF11181.8 EFA81083.1 - 0.1 13.1 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 Heat induced stress protein YflT G-alpha PF00503.20 EFA81084.1 - 5.1e-43 147.6 8.0 6.5e-43 147.2 8.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA81084.1 - 6.6e-06 25.7 0.2 0.00016 21.2 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family Rsm1 PF08600.10 EFA81085.1 - 0.00084 19.4 3.9 0.28 11.4 0.3 3.2 2 1 0 3 3 3 2 Rsm1-like DUF3439 PF11921.8 EFA81085.1 - 0.034 14.1 21.6 2.8 7.9 8.7 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3439) Zip PF02535.22 EFA81085.1 - 0.55 9.4 4.4 0.79 8.9 4.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SOG2 PF10428.9 EFA81085.1 - 1.8 7.7 26.0 2.1 7.4 26.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2448 PF10476.9 EFA81085.1 - 9.5 6.0 6.0 3 7.7 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) Rsm1 PF08600.10 EFA81086.1 - 7.9e-12 45.2 14.0 3.2e-08 33.6 0.0 5.0 4 2 2 6 6 6 2 Rsm1-like zf-C3HC PF07967.13 EFA81086.1 - 1.7e-05 24.9 0.0 1.7e-05 24.9 0.0 4.9 5 2 1 6 6 6 2 C3HC zinc finger-like DM PF00751.18 EFA81086.1 - 0.42 10.5 2.3 8 6.4 0.0 2.7 3 0 0 3 3 3 0 DM DNA binding domain Ribosomal_S26e PF01283.19 EFA81087.1 - 2.1e-46 156.8 9.1 2.7e-46 156.4 9.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_17 PF13534.6 EFA81087.1 - 0.094 13.3 3.5 0.38 11.3 1.8 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain ERM PF00769.19 EFA81088.1 - 0.00055 19.8 27.4 0.00066 19.6 27.4 1.0 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Fmp27_WPPW PF10359.9 EFA81088.1 - 0.012 14.5 17.7 0.014 14.3 17.7 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Mucin PF01456.17 EFA81088.1 - 0.015 15.3 13.8 0.021 14.8 13.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Spc7 PF08317.11 EFA81088.1 - 0.035 13.0 27.2 0.046 12.6 27.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 EFA81088.1 - 0.47 8.3 17.7 0.58 8.0 17.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 EFA81088.1 - 3.6 7.1 17.8 5.2 6.5 17.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GREB1 PF15782.5 EFA81088.1 - 8.2 3.4 18.0 9.6 3.2 18.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Kinesin PF00225.23 EFA81089.1 - 9.4e-99 330.5 6.0 9.4e-99 330.5 6.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFA81089.1 - 1.6e-25 89.8 1.5 1.6e-25 89.8 1.5 2.9 3 0 0 3 3 3 1 Microtubule binding Endonuc-dimeris PF09124.10 EFA81089.1 - 0.027 14.6 0.1 0.096 12.9 0.1 2.0 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation Surp PF01805.20 EFA81090.1 - 5.1e-17 61.6 0.1 1.8e-16 59.9 0.1 2.0 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 EFA81090.1 - 2.5e-12 46.4 0.0 5.1e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.8 EFA81090.1 - 0.00019 21.4 0.2 0.00044 20.2 0.2 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 RRM_5 PF13893.6 EFA81090.1 - 0.0025 17.4 0.0 0.0062 16.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 EFA81090.1 - 0.0041 17.7 67.1 0.0041 17.7 67.1 8.2 4 3 3 7 7 7 2 Pre-mRNA-splicing factor 38-associated hydrophilic C-term RRM_occluded PF16842.5 EFA81090.1 - 0.016 15.1 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif Ribosomal_L19e PF01280.20 EFA81091.1 - 1.7e-61 206.5 8.6 1.7e-61 206.5 8.6 1.7 2 0 0 2 2 2 1 Ribosomal protein L19e TFIIS_C PF01096.18 EFA81092.1 - 2.2e-19 69.0 5.7 3.7e-19 68.3 5.7 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Elf1 PF05129.13 EFA81092.1 - 0.18 11.9 6.6 0.24 11.5 6.2 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-DNL PF05180.12 EFA81092.1 - 0.35 10.8 5.9 0.65 10.0 5.9 1.5 1 1 0 1 1 1 0 DNL zinc finger zf_UBZ PF18439.1 EFA81092.1 - 0.53 9.9 0.3 0.53 9.9 0.3 2.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Zn_Tnp_IS1595 PF12760.7 EFA81092.1 - 0.82 9.7 9.0 0.96 9.5 5.9 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Guanylate_cyc PF00211.20 EFA81094.1 - 7.9e-24 84.3 0.5 4.9e-12 45.9 0.0 3.7 4 0 0 4 4 4 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 EFA81094.1 - 0.00013 22.4 2.1 0.015 15.7 0.1 3.6 3 1 1 4 4 4 1 AAA ATPase domain TPR_2 PF07719.17 EFA81094.1 - 0.00041 20.2 2.1 2.4 8.5 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81094.1 - 0.0024 18.1 3.8 0.017 15.4 0.0 3.7 3 1 0 4 4 4 1 Tetratricopeptide repeat AAA_22 PF13401.6 EFA81094.1 - 0.03 14.6 0.5 0.25 11.6 0.1 2.9 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 EFA81094.1 - 0.52 10.2 1.9 44 4.1 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ThiF PF00899.21 EFA81095.1 - 4.3e-83 278.4 0.0 3.6e-61 206.6 0.0 3.2 2 1 1 3 3 3 3 ThiF family UBA_e1_thiolCys PF10585.9 EFA81095.1 - 4.4e-77 259.4 11.9 7.1e-77 258.7 9.9 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EFA81095.1 - 4.1e-27 94.2 0.1 1.3e-26 92.5 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain Frag1 PF10277.9 EFA81095.1 - 6.2e-26 91.3 15.4 6.2e-26 91.3 15.4 1.9 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family E1_4HB PF16191.5 EFA81095.1 - 1.2e-12 47.8 0.0 1.2e-11 44.6 0.0 2.6 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle 2-Hacid_dh_C PF02826.19 EFA81095.1 - 0.067 12.6 0.2 4.4 6.6 0.0 3.1 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Seipin PF06775.14 EFA81096.1 - 1.4e-46 159.1 1.8 2.7e-46 158.2 1.8 1.5 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) NUDIX PF00293.28 EFA81097.1 - 3.1e-12 46.7 0.0 5.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Ank_5 PF13857.6 EFA81098.1 - 9.9e-31 105.4 11.3 7.1e-05 23.0 0.1 10.6 1 1 10 11 11 11 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81098.1 - 2.2e-29 101.8 4.8 5.1e-07 30.2 0.1 6.6 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81098.1 - 1.5e-28 98.8 14.5 2.9e-06 27.7 0.1 9.0 7 3 1 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81098.1 - 9.5e-18 62.5 7.7 1 10.1 0.1 11.2 11 2 2 13 13 13 4 Ankyrin repeat DUF5049 PF16468.5 EFA81098.1 - 3.1e-08 33.4 0.6 6.2 6.8 0.0 7.1 3 1 4 7 7 7 2 Domain of unknown function (DUF5049) DUF249 PF03158.13 EFA81098.1 - 9.9e-05 22.1 4.5 0.024 14.3 0.1 5.0 2 1 3 6 6 6 1 Multigene family 530 protein Ank PF00023.30 EFA81098.1 - 0.00024 21.4 1.4 12 6.6 0.1 6.4 5 2 2 7 7 7 1 Ankyrin repeat Kunitz_BPTI PF00014.23 EFA81098.1 - 0.00084 19.5 3.3 3.2 8.1 0.0 4.6 3 1 3 6 6 6 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Podoplanin PF05808.11 EFA81099.1 - 0.019 15.1 0.2 0.053 13.6 0.2 1.7 1 0 0 1 1 1 0 Podoplanin Adaptin_N PF01602.20 EFA81100.1 - 3.2e-114 382.4 17.9 4.5e-114 381.9 16.3 1.9 2 0 0 2 2 2 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EFA81100.1 - 2.3e-55 186.9 1.4 4.6e-55 185.9 1.4 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EFA81100.1 - 3e-28 98.3 0.0 7.1e-28 97.1 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EFA81100.1 - 4.2e-16 59.1 1.2 4.8e-07 30.1 0.0 5.3 3 2 1 5 5 5 3 HEAT repeats Cnd1 PF12717.7 EFA81100.1 - 2.5e-13 50.4 17.0 4.2e-06 26.9 1.1 5.4 3 1 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EFA81100.1 - 3.2e-05 24.0 0.0 8.2e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 EFA81100.1 - 0.00047 20.2 2.0 4 8.0 0.0 5.0 6 0 0 6 6 6 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EFA81100.1 - 0.26 11.9 7.2 52 4.5 0.0 5.0 3 1 2 5 5 5 0 Vacuolar 14 Fab1-binding region Acetyltransf_10 PF13673.7 EFA81101.1 - 4.7e-05 23.3 0.0 0.00011 22.2 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA81101.1 - 0.00044 20.6 0.0 0.00073 19.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA81101.1 - 0.00098 19.3 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MBF1 PF08523.10 EFA81101.1 - 0.075 13.5 0.3 0.16 12.5 0.3 1.4 1 0 0 1 1 1 0 Multiprotein bridging factor 1 PARP PF00644.20 EFA81102.1 - 6.8e-33 113.9 1.0 2e-31 109.1 1.0 2.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFA81102.1 - 4.4e-19 68.9 0.5 9.2e-19 67.9 0.5 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Ank_4 PF13637.6 EFA81102.1 - 1.3e-12 47.9 0.2 4.9e-08 33.4 0.0 3.2 2 2 1 3 3 3 2 Ankyrin repeats (many copies) BRCT PF00533.26 EFA81102.1 - 1.4e-12 47.8 2.9 4e-12 46.3 2.9 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA81102.1 - 4e-12 46.4 1.7 1.2e-11 44.8 1.7 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Ank_2 PF12796.7 EFA81102.1 - 1.6e-11 44.6 0.1 1.6e-08 35.0 0.0 3.1 2 1 1 3 3 2 1 Ankyrin repeats (3 copies) WGR PF05406.15 EFA81102.1 - 9e-10 38.5 0.2 2.2e-09 37.2 0.2 1.6 1 0 0 1 1 1 1 WGR domain Ank_5 PF13857.6 EFA81102.1 - 1.4e-08 34.9 1.3 0.019 15.3 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81102.1 - 1.4e-07 31.2 0.4 0.011 16.2 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFA81102.1 - 1.8e-06 28.1 1.0 0.00038 20.8 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat PTCB-BRCT PF12738.7 EFA81102.1 - 5.7e-05 23.0 0.6 0.00025 20.9 0.4 2.2 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 EFA81102.1 - 0.0033 17.7 1.4 0.0089 16.3 0.8 2.1 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain SPK PF04435.18 EFA81102.1 - 0.069 13.6 0.2 1.5 9.3 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF545) Peptidase_C48 PF02902.19 EFA81103.1 - 1.9e-40 139.0 3.5 1.9e-40 139.0 3.5 3.2 3 1 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain MMR_HSR1 PF01926.23 EFA81104.1 - 2.2e-48 163.1 1.1 6.8e-23 80.9 0.2 3.2 3 0 0 3 3 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 EFA81104.1 - 2.5e-23 82.2 1.3 7.2e-23 80.7 1.3 1.9 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 EFA81104.1 - 1.6e-22 79.7 1.0 1.9e-11 43.8 0.2 2.6 3 0 0 3 3 3 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFA81104.1 - 1.2e-10 41.2 20.6 0.056 13.0 0.0 5.9 3 1 0 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFA81104.1 - 9e-09 35.6 35.4 0.00073 19.6 0.1 6.7 4 3 2 6 6 4 3 Dynamin family Roc PF08477.13 EFA81104.1 - 2.6e-08 34.1 0.5 0.038 14.2 0.0 4.5 2 2 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFA81104.1 - 8.5e-08 32.3 3.0 0.032 14.1 0.0 4.3 4 0 0 4 4 4 2 RsgA GTPase Gtr1_RagA PF04670.12 EFA81104.1 - 3.8e-07 29.7 0.9 0.00083 18.8 0.7 2.6 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AIG1 PF04548.16 EFA81104.1 - 1.7e-06 27.5 20.0 0.001 18.4 0.0 4.0 2 2 2 4 4 4 2 AIG1 family Ras PF00071.22 EFA81104.1 - 2.8e-05 23.8 0.3 0.12 11.9 0.1 3.0 2 1 0 2 2 2 2 Ras family Arf PF00025.21 EFA81104.1 - 5.7e-05 22.6 4.0 0.26 10.7 0.1 3.8 2 2 0 2 2 2 2 ADP-ribosylation factor family AAA PF00004.29 EFA81104.1 - 0.0032 17.9 0.0 0.11 12.9 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EFA81104.1 - 0.0046 16.6 3.8 0.81 9.2 0.7 3.8 3 1 0 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EFA81104.1 - 0.0066 16.2 0.0 1.7 8.5 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain Nuc_deoxyrib_tr PF05014.15 EFA81104.1 - 0.0097 15.9 0.1 3.4 7.7 0.0 3.1 2 0 0 2 2 2 1 Nucleoside 2-deoxyribosyltransferase TniB PF05621.11 EFA81104.1 - 0.01 15.2 0.0 4.1 6.8 0.0 2.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 EFA81104.1 - 0.026 14.9 5.8 0.13 12.7 0.0 3.2 4 0 0 4 4 3 0 AAA ATPase domain Ploopntkinase3 PF18751.1 EFA81104.1 - 0.032 14.2 0.0 12 5.8 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MobB PF03205.14 EFA81104.1 - 0.035 14.0 0.3 3.6 7.5 0.1 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 EFA81104.1 - 0.045 14.1 1.2 14 6.1 0.0 3.9 4 0 0 4 4 3 0 RNA helicase AAA_22 PF13401.6 EFA81104.1 - 0.17 12.2 4.0 1.6 9.0 0.0 3.6 3 2 0 3 3 2 0 AAA domain AAA_24 PF13479.6 EFA81104.1 - 0.23 11.2 11.4 1.1 8.9 0.0 4.0 3 1 1 4 4 4 0 AAA domain ABC_tran PF00005.27 EFA81104.1 - 0.23 12.0 0.1 0.23 12.0 0.1 4.4 2 2 0 2 2 1 0 ABC transporter TP6A_N PF04406.14 EFA81104.1 - 0.31 11.0 2.2 0.34 10.9 0.1 2.2 2 0 0 2 2 1 0 Type IIB DNA topoisomerase MeaB PF03308.16 EFA81104.1 - 0.75 8.7 4.7 17 4.3 0.0 3.2 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FNIP PF05725.12 EFA81105.1 - 6.3e-05 23.1 21.8 0.0057 16.8 0.1 7.7 6 3 1 7 7 7 4 FNIP Repeat F-box_5 PF18511.1 EFA81105.1 - 0.035 13.7 0.1 0.077 12.6 0.1 1.5 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 EFA81105.1 - 0.067 13.1 0.4 0.17 11.8 0.4 1.7 1 0 0 1 1 1 0 F-box-like W2 PF02020.18 EFA81106.1 - 8.1e-19 67.5 8.8 3.4e-18 65.6 8.8 2.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EFA81106.1 - 2.3e-15 55.6 19.5 8e-06 25.4 1.6 5.0 1 1 4 5 5 5 5 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EFA81106.1 - 4.6e-12 46.0 0.0 2.7e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 Nucleotidyl transferase DUF4954 PF16314.5 EFA81106.1 - 0.00049 18.4 4.9 0.0012 17.1 4.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EFA81106.1 - 0.0031 17.2 18.8 0.028 14.2 2.8 4.1 1 1 3 4 4 4 3 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 EFA81106.1 - 0.014 15.8 0.0 0.024 15.0 0.0 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF4411 PF14367.6 EFA81106.1 - 0.075 12.9 1.9 0.15 12.0 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Fucokinase PF07959.12 EFA81106.1 - 0.32 9.9 4.3 1.1 8.1 4.4 1.8 1 1 0 1 1 1 0 L-fucokinase FNIP PF05725.12 EFA81107.1 - 4.5e-06 26.7 1.3 0.00014 22.0 0.1 2.9 2 0 0 2 2 2 1 FNIP Repeat F-box_5 PF18511.1 EFA81107.1 - 0.15 11.6 0.1 0.27 10.9 0.1 1.3 1 0 0 1 1 1 0 F-box Bin3 PF06859.12 EFA81108.1 - 6.3e-37 126.5 0.3 6.3e-37 126.5 0.3 2.7 2 0 0 2 2 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_25 PF13649.6 EFA81108.1 - 2.7e-10 40.8 0.0 0.00026 21.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EFA81108.1 - 4.8e-10 39.5 0.0 1.4e-09 38.0 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA81108.1 - 4.6e-09 36.9 2.9 1.1e-05 26.0 0.8 5.2 3 2 0 3 3 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFA81108.1 - 1.9e-08 34.8 0.1 0.01 16.5 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EFA81108.1 - 2.2e-07 30.8 5.6 0.00014 21.7 0.1 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.7 EFA81108.1 - 0.00017 21.5 0.3 0.0062 16.5 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFA81108.1 - 0.00056 19.5 1.9 0.011 15.3 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFA81108.1 - 0.0051 16.3 0.0 0.0051 16.3 0.0 3.7 3 2 1 4 4 3 1 Putative methyltransferase Presenilin PF01080.17 EFA81108.1 - 0.021 13.6 38.0 0.085 11.6 8.2 2.1 2 0 0 2 2 2 0 Presenilin DUF572 PF04502.13 EFA81108.1 - 1 8.9 43.3 0.19 11.4 10.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Dapper PF15268.6 EFA81108.1 - 1.2 7.9 42.5 1.6 7.5 25.1 2.0 2 0 0 2 2 2 0 Dapper ORC6 PF05460.13 EFA81108.1 - 1.9 7.7 33.3 0.088 12.1 10.7 2.2 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Band_3_cyto PF07565.13 EFA81108.1 - 6.9 6.4 23.5 0.78 9.5 4.1 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CdvA PF18822.1 EFA81109.1 - 0.24 11.3 1.4 5.1 7.0 0.2 2.1 1 1 1 2 2 2 0 CdvA-like coiled-coil domain SPX PF03105.19 EFA81109.1 - 3.9 7.3 5.4 4.9 7.0 5.4 1.3 1 0 0 1 1 1 0 SPX domain Muted PF14942.6 EFA81110.1 - 5.6e-16 59.2 12.1 9.9e-16 58.4 12.1 1.3 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein Thiolase_N PF00108.23 EFA81110.1 - 0.0072 15.7 0.3 0.027 13.8 0.0 1.8 1 1 1 2 2 2 1 Thiolase, N-terminal domain SLATT_1 PF18181.1 EFA81110.1 - 0.025 14.5 0.1 0.046 13.7 0.1 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Bromodomain PF00439.25 EFA81111.1 - 7.5e-18 64.4 0.1 1.4e-17 63.6 0.1 1.4 1 0 0 1 1 1 1 Bromodomain FHA PF00498.26 EFA81112.1 - 3.1e-17 62.7 0.0 8.1e-17 61.3 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFA81112.1 - 6.7e-08 32.7 0.0 2e-07 31.2 0.0 1.8 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain SR-25 PF10500.9 EFA81112.1 - 8.3e-07 28.9 34.6 0.0021 17.7 17.3 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF4603 PF15376.6 EFA81112.1 - 0.0008 17.0 10.4 0.0008 17.0 10.4 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4603) FHA_2 PF17913.1 EFA81112.1 - 0.017 15.4 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 FHA domain LRIF1 PF15741.5 EFA81112.1 - 0.026 13.1 19.6 0.037 12.6 19.6 1.2 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 DUF4228 PF14009.6 EFA81112.1 - 4.5 7.6 15.9 1.3 9.4 4.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) GREB1 PF15782.5 EFA81112.1 - 4.8 4.2 13.4 5.5 4.0 13.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Eapp_C PF10238.9 EFA81112.1 - 6.7 6.8 12.6 4.2 7.4 2.4 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein CCDC106 PF15794.5 EFA81112.1 - 9.5 5.9 28.5 0.82 9.3 9.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF702 PF05142.12 EFA81112.1 - 9.6 6.7 10.5 4.6 7.7 3.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) C2 PF00168.30 EFA81113.1 - 4.6e-10 39.7 0.0 5.9e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 C2 domain DUF4385 PF14328.6 EFA81113.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4385) ubiquitin PF00240.23 EFA81114.1 - 0.00026 20.7 1.7 14 5.6 0.1 4.6 3 1 1 4 4 4 3 Ubiquitin family Beta_helix_2 PF18835.1 EFA81114.1 - 0.17 11.6 0.4 25 4.7 0.1 2.8 2 0 0 2 2 2 0 Beta helix repeat of Inulin fructotransferase IL1_propep PF02394.16 EFA81114.1 - 5.3 8.0 7.6 29 5.6 0.4 3.4 3 0 0 3 3 3 0 Interleukin-1 propeptide PIG-L PF02585.17 EFA81115.1 - 2.7e-14 53.9 3.5 3.8e-14 53.4 1.6 2.4 2 1 0 2 2 2 1 GlcNAc-PI de-N-acetylase F-box_5 PF18511.1 EFA81115.1 - 0.001 18.6 0.5 0.0022 17.5 0.1 1.7 2 0 0 2 2 2 1 F-box HhH-GPD PF00730.25 EFA81115.1 - 0.029 14.8 0.0 0.54 10.7 0.0 2.7 3 0 0 3 3 3 0 HhH-GPD superfamily base excision DNA repair protein CD20 PF04103.15 EFA81115.1 - 0.076 13.1 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 CD20-like family Herpes_LMP1 PF05297.11 EFA81115.1 - 0.54 9.4 4.4 0.83 8.8 4.4 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RCC1 PF00415.18 EFA81116.1 - 8e-34 116.0 8.0 1.5e-10 41.5 0.1 5.5 4 2 1 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA81116.1 - 2.6e-21 74.9 14.7 1.8e-05 24.4 0.8 5.5 4 1 1 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFA81116.1 - 8.6e-19 67.8 4.2 6.9e-18 64.9 1.5 2.9 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EFA81116.1 - 9.8e-05 22.4 0.6 0.00096 19.2 0.0 2.5 3 0 0 3 3 3 1 BTB And C-terminal Kelch CBM49 PF09478.10 EFA81117.1 - 1.2e-06 28.7 1.7 1.9e-06 28.0 1.5 1.4 1 1 0 1 1 1 1 Carbohydrate binding domain CBM49 BRX_assoc PF16627.5 EFA81117.1 - 0.14 12.3 0.2 0.35 11.0 0.2 1.6 2 0 0 2 2 2 0 Unstructured region between BRX_N and BRX domain Tweety PF04906.13 EFA81119.1 - 4.5 5.8 7.7 1.8 7.1 4.5 1.7 2 0 0 2 2 2 0 Tweety Pre-PUA PF17832.1 EFA81120.1 - 1.6e-20 73.5 1.5 3.9e-20 72.3 0.5 2.3 2 0 0 2 2 2 1 Pre-PUA-like domain SUI1 PF01253.22 EFA81120.1 - 5.9e-14 52.4 0.6 2.5e-13 50.4 0.1 2.4 2 0 0 2 2 2 1 Translation initiation factor SUI1 PUA PF01472.20 EFA81120.1 - 0.00053 19.9 0.0 0.0017 18.3 0.0 2.0 1 0 0 1 1 1 1 PUA domain VitD-bind_III PF09164.10 EFA81120.1 - 0.016 15.2 2.5 0.51 10.4 0.1 2.8 3 0 0 3 3 3 0 Vitamin D binding protein, domain III FAM76 PF16046.5 EFA81120.1 - 0.087 12.2 0.3 0.23 10.8 0.3 1.6 1 0 0 1 1 1 0 FAM76 protein DUF4611 PF15387.6 EFA81120.1 - 1.9 8.8 6.8 6.4 7.1 6.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) UCH PF00443.29 EFA81121.1 - 6.2e-29 101.3 47.9 3.8e-26 92.1 47.9 3.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFA81121.1 - 9.7e-07 28.5 0.3 5e-06 26.2 0.3 2.3 1 0 0 1 1 1 1 Ubiquitin family DUSP PF06337.12 EFA81121.1 - 5.5e-06 26.9 2.2 5.4e-05 23.7 0.2 7.2 6 3 0 6 6 6 2 DUSP domain Utp14 PF04615.13 EFA81121.1 - 0.0077 14.9 32.7 0.073 11.6 12.0 2.2 2 0 0 2 2 2 2 Utp14 protein UCH_1 PF13423.6 EFA81121.1 - 0.022 14.3 56.2 0.48 10.0 51.3 4.3 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase GFA PF04828.14 EFA81121.1 - 0.31 11.4 3.2 1 9.7 0.1 3.2 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme SF3b1 PF08920.10 EFA81122.1 - 6.1e-34 117.0 4.2 7.1e-33 113.6 0.1 2.8 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT PF02985.22 EFA81122.1 - 1.5e-12 46.6 4.8 0.059 13.7 0.0 8.4 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 EFA81122.1 - 1.8e-10 41.1 2.2 0.55 10.7 0.0 6.9 4 2 3 7 7 7 4 HEAT repeats Cnd1 PF12717.7 EFA81122.1 - 8.8e-10 38.9 1.6 0.15 12.1 0.1 5.4 4 2 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFA81122.1 - 1.4e-09 38.2 0.1 0.41 11.2 0.0 6.4 7 1 1 8 8 8 3 HEAT-like repeat IFRD PF05004.13 EFA81122.1 - 1e-06 28.1 0.0 0.0031 16.7 0.0 3.5 3 0 0 3 3 3 2 Interferon-related developmental regulator (IFRD) PHD PF00628.29 EFA81122.1 - 1.8e-05 24.5 6.6 1.8e-05 24.5 6.6 3.1 3 0 0 3 3 2 1 PHD-finger Vac14_Fab1_bd PF12755.7 EFA81122.1 - 0.00043 20.8 1.2 4 8.1 0.0 4.8 5 0 0 5 5 4 1 Vacuolar 14 Fab1-binding region ParcG PF10274.9 EFA81122.1 - 0.001 19.3 2.0 1.2 9.3 0.1 4.3 2 1 3 5 5 5 2 Parkin co-regulated protein CLASP_N PF12348.8 EFA81122.1 - 0.0036 16.9 0.4 2.8 7.5 0.0 3.3 3 0 0 3 3 3 2 CLASP N terminal PHD_4 PF16866.5 EFA81122.1 - 0.062 13.4 5.0 0.26 11.4 5.0 2.2 1 0 0 1 1 1 0 PHD-finger DUF3385 PF11865.8 EFA81122.1 - 1.4 8.9 10.2 4.4 7.2 0.2 5.3 3 1 1 4 4 4 0 Domain of unknown function (DUF3385) TERB2 PF15101.6 EFA81123.1 - 0.00081 19.5 1.1 0.00081 19.5 1.1 5.2 4 2 1 5 5 5 1 Telomere-associated protein TERB2 PH PF00169.29 EFA81124.1 - 1.8e-11 44.4 0.0 9.8e-11 42.1 0.0 2.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFA81124.1 - 2.1e-05 24.7 0.0 0.00051 20.3 0.0 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain Spc7 PF08317.11 EFA81124.1 - 0.00026 20.0 37.4 0.00026 20.0 37.4 9.8 1 1 9 10 10 10 4 Spc7 kinetochore protein Filament PF00038.21 EFA81124.1 - 0.0061 16.2 17.2 0.0061 16.2 17.2 8.2 1 1 6 8 8 8 3 Intermediate filament protein HrpB7 PF09486.10 EFA81124.1 - 0.0069 16.8 16.9 0.0069 16.8 16.9 10.8 2 1 6 11 11 11 3 Bacterial type III secretion protein (HrpB7) KASH_CCD PF14662.6 EFA81124.1 - 0.0078 16.1 22.0 0.0078 16.1 22.0 11.0 1 1 8 10 10 10 3 Coiled-coil region of CCDC155 or KASH Bcr-Abl_Oligo PF09036.10 EFA81124.1 - 0.0079 16.2 2.8 0.0079 16.2 2.8 9.8 7 3 3 10 10 10 3 Bcr-Abl oncoprotein oligomerisation domain Fib_alpha PF08702.10 EFA81124.1 - 0.0085 16.3 9.7 0.0085 16.3 9.7 11.9 1 1 11 14 14 14 1 Fibrinogen alpha/beta chain family ZapB PF06005.12 EFA81124.1 - 0.064 13.7 0.3 0.064 13.7 0.3 18.8 1 1 9 11 11 11 0 Cell division protein ZapB RhoGEF PF00621.20 EFA81125.1 - 3.7e-36 125.1 5.6 3.7e-36 125.1 5.6 2.4 3 0 0 3 3 3 1 RhoGEF domain Slu7 PF11708.8 EFA81126.1 - 4.4e-89 298.8 12.3 4.4e-89 298.8 12.3 2.8 3 0 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.23 EFA81126.1 - 0.023 14.8 1.9 0.043 13.9 1.9 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EFA81126.1 - 0.079 12.7 2.3 0.16 11.7 2.3 1.5 1 0 0 1 1 1 0 Zinc knuckle Nuc_sug_transp PF04142.15 EFA81127.1 - 1.6e-07 30.8 0.5 3.5e-07 29.7 0.3 1.7 1 1 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 EFA81127.1 - 2.2e-07 30.4 2.9 2.2e-07 30.4 2.9 2.0 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport CRT-like PF08627.10 EFA81127.1 - 3.5e-07 29.5 4.0 3.5e-07 29.5 4.0 1.9 2 1 0 3 3 3 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 EFA81127.1 - 6.6e-06 25.7 9.4 5.1e-05 22.8 5.1 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EFA81127.1 - 0.00028 21.1 12.6 0.00028 21.1 12.6 2.6 2 2 1 3 3 3 1 EamA-like transporter family Chordopox_A13L PF05961.11 EFA81127.1 - 0.08 13.2 0.2 2.6 8.4 0.0 2.8 3 0 0 3 3 3 0 Chordopoxvirus A13L protein AAA PF00004.29 EFA81128.1 - 0.00024 21.5 1.7 0.0026 18.2 0.1 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFA81128.1 - 0.025 14.7 0.0 0.12 12.5 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFA81128.1 - 0.056 13.7 0.2 0.71 10.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFA81128.1 - 0.058 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIR_2 PF13676.6 EFA81128.1 - 0.1 13.2 0.0 0.23 12.1 0.0 1.6 1 0 0 1 1 1 0 TIR domain AAA_14 PF13173.6 EFA81128.1 - 0.18 11.8 5.8 1.7 8.7 0.0 3.9 3 1 1 4 4 4 0 AAA domain TPR_2 PF07719.17 EFA81129.1 - 0.14 12.4 6.4 0.94 9.8 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3270 PF11674.8 EFA81131.1 - 0.063 13.5 1.0 0.65 10.2 1.0 2.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) TAN PF11640.8 EFA81131.1 - 0.065 13.4 0.3 0.35 11.0 0.3 2.3 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair P2X_receptor PF00864.19 EFA81132.1 - 5.5e-11 42.2 11.8 5.4e-10 38.9 2.3 3.8 2 2 1 3 3 3 3 ATP P2X receptor Pkinase PF00069.25 EFA81133.1 - 1.6e-68 230.9 0.0 3.1e-68 230.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81133.1 - 2.1e-48 164.8 0.0 3.6e-48 164.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MCU PF04678.13 EFA81133.1 - 2.5e-45 154.7 0.0 5.3e-45 153.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial calcium uniporter COR PF16095.5 EFA81133.1 - 8.3e-07 29.0 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Kinase-like PF14531.6 EFA81133.1 - 0.00015 21.2 0.0 0.012 15.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFA81133.1 - 0.00025 20.0 0.0 0.00054 18.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase DUF1241 PF06840.11 EFA81133.1 - 0.078 12.6 0.1 0.29 10.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) 2-ph_phosp PF04029.14 EFA81134.1 - 1.9e-70 236.6 0.1 2.5e-70 236.2 0.1 1.0 1 0 0 1 1 1 1 2-phosphosulpholactate phosphatase SRP54 PF00448.22 EFA81136.1 - 4.1e-75 251.7 1.1 6.6e-75 251.1 1.1 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFA81136.1 - 6e-24 84.5 13.0 1.8e-23 83.0 0.2 4.2 4 1 1 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.19 EFA81136.1 - 1.4e-13 50.8 3.2 1.4e-13 50.8 3.2 2.2 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain SRPRB PF09439.10 EFA81136.1 - 9.1e-05 22.0 1.4 0.075 12.5 0.1 2.5 1 1 0 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFA81136.1 - 0.00014 21.9 0.3 0.00051 20.1 0.3 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EFA81136.1 - 0.0004 20.0 3.2 0.005 16.4 1.5 2.6 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EFA81136.1 - 0.0013 19.1 0.0 0.0024 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EFA81136.1 - 0.0019 18.4 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFA81136.1 - 0.0026 17.8 0.1 0.022 14.8 0.0 2.6 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EFA81136.1 - 0.0044 16.8 0.2 0.015 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EFA81136.1 - 0.0086 16.5 2.8 0.0092 16.4 0.1 2.5 3 0 0 3 3 2 1 AAA domain MobB PF03205.14 EFA81136.1 - 0.013 15.4 0.5 0.065 13.1 0.5 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 EFA81136.1 - 0.016 14.2 0.1 0.032 13.2 0.1 1.6 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EFA81136.1 - 0.022 15.2 2.6 0.066 13.6 0.5 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFA81136.1 - 0.023 15.0 0.3 0.16 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFA81136.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_28 PF13521.6 EFA81136.1 - 0.082 13.1 0.0 0.19 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 EFA81136.1 - 0.093 12.2 0.1 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF2209 PF09974.9 EFA81136.1 - 0.14 12.5 0.1 0.39 11.0 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Ribonuc_L-PSP PF01042.21 EFA81137.1 - 3.7e-18 65.7 0.1 4.4e-18 65.4 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Mucin PF01456.17 EFA81138.1 - 1 9.4 32.3 1.1 9.2 32.3 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 EFA81138.1 - 4.9 5.2 11.0 4.5 5.3 11.0 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus POPLD PF08170.12 EFA81140.1 - 0.018 15.4 0.1 7.7 6.9 0.0 2.2 2 0 0 2 2 2 0 POPLD (NUC188) domain Kelch_6 PF13964.6 EFA81142.1 - 4.3e-09 36.3 7.2 3.4e-05 24.0 0.0 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 EFA81142.1 - 4.9e-05 23.2 4.0 0.031 14.3 0.1 3.1 3 0 0 3 3 3 2 Kelch motif SEO_C PF14577.6 EFA81142.1 - 0.011 15.2 0.8 0.027 13.9 0.8 1.7 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Ntox28 PF15605.6 EFA81142.1 - 0.029 14.6 1.1 0.07 13.4 0.4 2.0 2 0 0 2 2 2 0 Bacterial toxin 28 Kelch_4 PF13418.6 EFA81142.1 - 0.038 14.0 2.4 7.2 6.7 0.0 3.8 3 1 0 3 3 3 0 Galactose oxidase, central domain PPR_2 PF13041.6 EFA81143.1 - 1.2e-07 31.8 1.2 0.0014 18.8 0.1 2.6 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 EFA81143.1 - 0.0047 17.1 0.4 4.7 7.7 0.0 3.6 2 1 0 2 2 2 2 PPR repeat PPR_1 PF12854.7 EFA81143.1 - 0.055 13.2 0.1 25 4.7 0.0 3.4 3 1 0 3 3 3 0 PPR repeat p450 PF00067.22 EFA81144.1 - 5.3e-94 315.6 0.4 7.1e-94 315.2 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 SR-25 PF10500.9 EFA81144.1 - 8.8 5.9 14.3 75 2.8 15.6 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein p450 PF00067.22 EFA81145.1 - 4.5e-91 305.9 0.2 6.1e-91 305.5 0.2 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF2594 PF10769.9 EFA81145.1 - 0.16 12.0 0.1 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2594) DUF2505 PF10698.9 EFA81146.1 - 0.013 15.7 0.0 0.024 14.7 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2505) Prefoldin_2 PF01920.20 EFA81148.1 - 3.8e-17 62.2 8.7 4.8e-17 61.9 8.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit LEDGF PF11467.8 EFA81148.1 - 0.026 14.1 2.8 0.18 11.5 0.3 2.2 1 1 1 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) Vps51 PF08700.11 EFA81148.1 - 0.25 11.5 4.7 9 6.5 0.3 2.7 2 1 0 2 2 2 0 Vps51/Vps67 XhlA PF10779.9 EFA81148.1 - 6 7.2 11.9 2.7 8.3 1.4 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF3439 PF11921.8 EFA81149.1 - 0.32 10.9 7.0 0.17 11.9 5.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Chorein_N PF12624.7 EFA81151.1 - 1.8e-25 89.3 0.4 2.4e-25 88.9 0.4 1.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_mid_rpt PF16910.5 EFA81152.1 - 8.3e-53 179.2 2.7 8.3e-53 179.2 2.7 7.9 8 2 1 9 9 9 1 Repeating coiled region of VPS13 VPS13_C PF16909.5 EFA81153.1 - 1.1e-38 132.8 7.1 2.9e-33 115.1 1.2 3.5 2 1 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 EFA81153.1 - 8.2e-25 87.7 0.6 1.9e-24 86.5 0.6 1.7 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 EFA81153.1 - 8.4e-05 22.8 0.0 0.0002 21.6 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Phospholip_B PF04916.13 EFA81154.1 - 1.1e-159 532.5 18.5 1.3e-159 532.2 18.5 1.0 1 0 0 1 1 1 1 Phospholipase B zf-UBR PF02207.20 EFA81155.1 - 2.5e-11 43.6 11.6 2.5e-11 43.6 11.6 3.2 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) zf-RING_5 PF14634.6 EFA81155.1 - 6.2e-05 22.9 3.3 6.2e-05 22.9 3.3 3.8 4 0 0 4 4 4 1 zinc-RING finger domain SMN PF06003.12 EFA81155.1 - 0.0035 16.6 0.4 0.0059 15.9 0.4 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) zf-RING_2 PF13639.6 EFA81155.1 - 0.0054 17.0 3.2 0.0054 17.0 3.2 3.8 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA81155.1 - 0.0075 16.1 2.8 0.0075 16.1 2.8 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA81155.1 - 0.0099 15.7 3.0 0.0099 15.7 3.0 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) ELL PF10390.9 EFA81155.1 - 0.052 13.0 0.3 0.13 11.7 0.3 1.6 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL DUF3800 PF12686.7 EFA81155.1 - 0.065 13.9 0.0 18 6.0 0.0 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) DDHD PF02862.17 EFA81155.1 - 0.1 12.8 0.8 5.2 7.2 0.1 2.3 2 0 0 2 2 2 0 DDHD domain Myosin_head PF00063.21 EFA81156.1 - 5e-180 600.1 12.3 1.7e-144 482.7 0.9 2.6 1 1 1 2 2 2 2 Myosin head (motor domain) RhoGEF PF00621.20 EFA81156.1 - 2.9e-48 164.5 7.1 2.9e-48 164.5 7.1 5.6 4 1 1 5 5 4 1 RhoGEF domain PH PF00169.29 EFA81156.1 - 1.7e-06 28.5 0.6 1.1e-05 25.9 0.1 2.9 2 0 0 2 2 2 1 PH domain IQ PF00612.27 EFA81156.1 - 3.7e-06 26.2 3.5 0.062 13.1 0.4 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif PH_13 PF16652.5 EFA81156.1 - 1.2e-05 25.2 0.1 1.2e-05 25.2 0.1 3.8 2 1 1 3 3 2 1 Pleckstrin homology domain Myosin_N PF02736.19 EFA81156.1 - 0.00015 21.5 0.0 0.00034 20.4 0.0 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EFA81156.1 - 0.016 15.5 1.5 0.093 13.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EFA81156.1 - 0.066 13.6 0.0 0.066 13.6 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain RNA_helicase PF00910.22 EFA81156.1 - 0.094 13.1 0.5 6.5 7.2 0.0 3.1 2 0 0 2 2 2 0 RNA helicase BUD22 PF09073.10 EFA81156.1 - 0.48 9.7 40.7 0.99 8.7 40.7 1.4 1 0 0 1 1 1 0 BUD22 DUF3439 PF11921.8 EFA81156.1 - 3.1 7.8 10.1 7.7 6.5 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 EFA81157.1 - 1.1e-22 80.7 0.2 1.7e-22 80.1 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81157.1 - 2.5e-14 53.2 0.0 3.5e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA81157.1 - 0.012 15.6 0.0 0.094 12.6 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family EF-hand_7 PF13499.6 EFA81158.1 - 7.7e-21 74.3 4.0 2.8e-05 24.5 0.0 4.9 3 2 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 EFA81158.1 - 7.1e-18 62.8 14.9 0.00018 20.8 0.5 6.0 7 0 0 7 7 7 4 EF hand EF-hand_6 PF13405.6 EFA81158.1 - 2.8e-16 58.0 14.5 0.00015 21.4 0.4 6.8 5 1 1 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 EFA81158.1 - 1.1e-11 44.4 8.5 0.0016 18.2 0.0 4.5 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA81158.1 - 1.3e-10 40.3 11.7 0.0023 17.4 0.5 3.7 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 EFA81158.1 - 3.1e-05 23.8 4.2 1.1 9.3 0.0 3.8 3 1 1 4 4 4 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFA81158.1 - 0.0018 18.6 2.5 0.048 14.0 0.0 3.5 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFA81158.1 - 0.018 15.3 0.0 4.2 7.8 0.0 3.7 3 1 0 3 3 3 0 EF-hand domain Dockerin_1 PF00404.18 EFA81158.1 - 0.025 14.8 0.7 0.23 11.7 0.1 2.9 3 1 0 3 3 3 0 Dockerin type I domain Peptidase_M14 PF00246.24 EFA81159.1 - 1.7e-66 224.9 0.6 1.7e-66 224.9 0.6 2.1 2 0 0 2 2 2 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EFA81159.1 - 3.9e-05 22.9 0.0 7.1e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family PEGA PF08308.11 EFA81159.1 - 0.0001 22.1 0.0 0.00034 20.4 0.0 1.9 1 0 0 1 1 1 1 PEGA domain CarboxypepD_reg PF13620.6 EFA81159.1 - 0.049 13.9 0.0 0.049 13.9 0.0 2.1 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain Foie-gras_1 PF11817.8 EFA81159.1 - 0.18 11.4 1.1 0.32 10.6 1.1 1.3 1 0 0 1 1 1 0 Foie gras liver health family 1 RGS PF00615.19 EFA81160.1 - 6.8e-20 71.5 6.1 2e-15 57.1 3.1 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain RGS-like PF09128.11 EFA81160.1 - 0.013 15.2 0.2 0.024 14.4 0.2 1.4 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Ank_4 PF13637.6 EFA81161.1 - 3.9e-25 87.9 6.1 2.5e-05 24.7 0.1 7.5 6 3 2 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81161.1 - 1.6e-23 83.1 2.5 1.9e-05 25.1 0.1 7.0 3 3 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81161.1 - 3.7e-15 55.8 1.8 0.022 15.1 0.1 8.5 5 3 4 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81161.1 - 4.8e-14 51.1 4.2 0.54 11.0 0.0 11.2 12 1 1 13 13 13 2 Ankyrin repeat IFT81_CH PF18383.1 EFA81161.1 - 0.0002 21.6 0.4 0.81 9.9 0.1 3.3 3 0 0 3 3 3 2 Intraflagellar transport 81 calponin homology domain Ank PF00023.30 EFA81161.1 - 0.006 17.0 0.4 1.5e+02 3.1 0.0 6.3 7 1 0 7 7 7 0 Ankyrin repeat Ndc80_HEC PF03801.13 EFA81161.1 - 0.39 10.3 3.8 39 3.9 0.1 4.1 4 2 0 4 4 4 0 HEC/Ndc80p family Ras PF00071.22 EFA81162.1 - 1.3e-57 193.9 0.0 1.6e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA81162.1 - 1.1e-23 83.7 0.0 2.3e-23 82.7 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA81162.1 - 3.5e-05 23.3 0.0 7.2e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family PI-PLC-X PF00388.19 EFA81162.1 - 0.09 12.4 0.0 0.59 9.7 0.0 2.0 1 1 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Adenine_glyco PF03352.13 EFA81163.1 - 7.2e-70 234.3 3.2 7.2e-70 234.3 3.2 2.4 2 1 0 2 2 2 1 Methyladenine glycosylase FAM176 PF14851.6 EFA81163.1 - 0.17 11.6 10.1 0.86 9.3 3.2 2.3 2 0 0 2 2 2 0 FAM176 family PBP1_TM PF14812.6 EFA81163.1 - 4.1 7.9 9.5 5.6 7.4 2.2 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CPSF100_C PF13299.6 EFA81163.1 - 6.7 6.9 15.1 2.6 8.2 1.8 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Coilin_N PF15862.5 EFA81163.1 - 9.3 6.0 20.1 1.6 8.5 8.6 2.3 2 0 0 2 2 2 0 Coilin N-terminus Adenine_glyco PF03352.13 EFA81164.1 - 2.5e-67 226.1 0.0 3.2e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Methyladenine glycosylase GST_C_3 PF14497.6 EFA81167.1 - 3e-17 62.6 0.0 4.6e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA81167.1 - 9.9e-08 32.2 0.0 2.1e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA81167.1 - 0.00015 21.9 0.0 0.00026 21.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA81167.1 - 0.0016 18.8 0.0 0.0086 16.5 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA81167.1 - 0.0034 17.4 0.0 0.01 15.9 0.0 1.9 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GTP_EFTU PF00009.27 EFA81168.1 - 9.6e-54 181.9 0.2 1.4e-53 181.3 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFA81168.1 - 1.3e-18 66.8 0.0 3.2e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EFA81168.1 - 1.4e-06 28.4 0.1 3.4e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFA81168.1 - 1.4e-06 28.6 4.1 1.4e-06 28.6 4.1 2.6 3 0 0 3 3 3 1 Elongation factor Tu domain 2 Septin PF00735.18 EFA81168.1 - 0.0011 18.3 0.1 0.0023 17.3 0.1 1.4 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 EFA81168.1 - 0.0023 17.4 1.4 0.0049 16.3 0.0 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 EFA81168.1 - 0.0047 17.0 0.2 0.035 14.2 0.2 2.5 1 1 0 1 1 1 1 Dynamin family MeaB PF03308.16 EFA81168.1 - 0.01 14.8 1.1 2.6 7.0 0.0 2.8 3 1 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 EFA81168.1 - 0.013 15.0 0.1 0.14 11.7 0.1 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B EFG_II PF14492.6 EFA81168.1 - 0.017 15.2 0.1 0.049 13.7 0.1 1.8 1 0 0 1 1 1 0 Elongation Factor G, domain II Roc PF08477.13 EFA81168.1 - 0.057 13.6 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ank_4 PF13637.6 EFA81169.1 - 0.14 12.8 0.0 2.2 9.0 0.0 2.8 2 1 0 2 2 2 0 Ankyrin repeats (many copies) Rota_NSP4 PF01452.16 EFA81170.1 - 0.01 15.5 0.4 0.052 13.2 0.2 2.2 2 0 0 2 2 2 0 Rotavirus non structural protein DUF3447 PF11929.8 EFA81170.1 - 0.061 13.3 0.3 0.061 13.3 0.3 4.4 4 1 2 6 6 6 0 Domain of unknown function (DUF3447) Phage_DsbA PF11126.8 EFA81170.1 - 0.089 13.0 1.4 0.17 12.1 0.1 2.1 2 0 0 2 2 2 0 Transcriptional regulator DsbA LIM_bind PF01803.16 EFA81171.1 - 6.8e-09 35.6 0.0 6.8e-09 35.6 0.0 9.4 3 1 3 7 7 7 1 LIM-domain binding protein Metallophos PF00149.28 EFA81172.1 - 1.4e-41 143.2 0.1 1.8e-41 142.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFA81172.1 - 3.8e-17 62.5 1.4 7.6e-17 61.5 0.5 2.0 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain IBR PF01485.21 EFA81173.1 - 4.3e-14 52.5 48.3 4.2e-09 36.5 9.9 4.9 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain CUE PF02845.16 EFA81173.1 - 2.2e-08 33.6 0.6 5.4e-08 32.4 0.5 1.8 1 1 0 1 1 1 1 CUE domain zf-RING_UBOX PF13445.6 EFA81173.1 - 6.9e-06 26.0 2.2 6.9e-06 26.0 2.2 4.4 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA81173.1 - 3.3e-05 23.7 8.5 3.3e-05 23.7 8.5 6.2 5 2 2 7 7 7 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA81173.1 - 4.4e-05 23.7 7.0 4.4e-05 23.7 7.0 5.6 4 2 1 5 5 5 2 Ring finger domain zf-C3HC4_2 PF13923.6 EFA81173.1 - 0.00018 21.3 4.4 0.00018 21.3 4.4 6.2 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA81173.1 - 0.0073 16.0 6.3 0.0073 16.0 6.3 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 EFA81173.1 - 0.011 15.7 7.9 0.011 15.7 7.9 4.7 3 1 1 4 4 4 0 zinc-RING finger domain Ank_2 PF12796.7 EFA81174.1 - 2.8e-25 88.7 9.3 2e-06 28.3 0.1 6.2 2 1 5 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81174.1 - 3.7e-24 84.8 6.5 0.00015 22.2 0.1 9.1 7 3 4 11 11 11 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81174.1 - 1.8e-19 69.6 12.3 0.00063 20.0 0.1 10.7 4 1 7 11 11 11 6 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA81174.1 - 8.2e-12 44.8 0.3 1.3 8.9 0.0 8.4 8 1 2 10 10 10 3 Domain of unknown function (DUF5049) Ank_3 PF13606.6 EFA81174.1 - 1.3e-09 37.5 5.6 37 5.3 0.0 10.3 11 1 1 12 12 12 0 Ankyrin repeat DUF3447 PF11929.8 EFA81174.1 - 0.00086 19.2 5.2 0.96 9.5 0.0 4.6 3 1 2 5 5 5 2 Domain of unknown function (DUF3447) DUF4411 PF14367.6 EFA81174.1 - 0.0073 16.2 3.7 11 5.9 0.0 4.5 2 1 3 5 5 5 1 Domain of unknown function (DUF4411) Ank PF00023.30 EFA81174.1 - 0.53 10.8 4.6 2.2e+02 2.6 0.3 5.8 5 1 0 5 5 5 0 Ankyrin repeat Kelch_1 PF01344.25 EFA81175.1 - 0.00047 19.7 0.1 0.0013 18.2 0.1 1.8 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 EFA81175.1 - 0.074 13.1 0.0 0.39 10.8 0.0 2.3 1 0 0 1 1 1 0 Kelch motif DUF2083 PF09856.9 EFA81175.1 - 0.19 11.5 0.0 0.3 10.9 0.0 1.2 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) FNIP PF05725.12 EFA81177.1 - 4.6e-21 74.7 23.2 6.6e-07 29.4 0.0 7.7 5 1 2 7 7 7 6 FNIP Repeat F-box_4 PF15966.5 EFA81177.1 - 0.035 14.0 0.2 0.12 12.3 0.2 2.0 1 1 0 1 1 1 0 F-box Urm1 PF09138.11 EFA81177.1 - 0.059 13.7 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) DUF2778 PF10908.8 EFA81177.1 - 0.14 12.4 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2778) DarA_N PF18788.1 EFA81178.1 - 0.092 12.8 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Defence against restriction A N-terminal Actin PF00022.19 EFA81179.1 - 6.2e-131 436.7 0.0 2.3e-130 434.9 0.0 1.7 1 1 0 1 1 1 1 Actin Cation_ATPase_C PF00689.21 EFA81180.1 - 4.3e-38 130.8 10.6 4.3e-38 130.8 10.6 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFA81180.1 - 1e-37 129.4 0.7 1e-37 129.4 0.7 3.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFA81180.1 - 3.1e-20 72.1 0.0 7.2e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA81180.1 - 2.1e-17 64.1 0.0 5.1e-17 62.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA81180.1 - 1.6e-13 50.1 0.4 5.7e-13 48.4 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Beta_helix PF13229.6 EFA81180.1 - 4.4e-10 39.6 59.1 4.7e-08 33.0 27.3 3.0 1 1 1 2 2 2 2 Right handed beta helix region Hydrolase_3 PF08282.12 EFA81180.1 - 0.022 14.5 1.7 0.11 12.2 0.4 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4957 PF16318.5 EFA81180.1 - 0.22 11.5 37.8 0.43 10.5 2.6 5.8 2 2 3 5 5 5 0 Domain of unknown function (DUF4957) LuxT_C PF18285.1 EFA81181.1 - 0.0097 16.4 1.0 0.2 12.2 0.1 2.9 2 1 1 3 3 3 1 Tetracycline repressor LuxT C-terminal domain RPAP3_C PF13877.6 EFA81181.1 - 3.3 8.3 7.6 0.4 11.3 0.2 3.2 4 0 0 4 4 4 0 Potential Monad-binding region of RPAP3 Phos_pyr_kin PF08543.12 EFA81182.1 - 4.9e-17 62.1 0.0 6.7e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EFA81182.1 - 2.9e-09 36.7 0.4 1.2e-08 34.7 0.4 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase PPR_3 PF13812.6 EFA81182.1 - 0.041 14.0 0.4 0.13 12.3 0.2 2.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain DAHP_synth_2 PF01474.16 EFA81182.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Class-II DAHP synthetase family NPHI_C PF08469.10 EFA81183.1 - 0.00023 21.1 0.6 0.00042 20.3 0.6 1.4 1 1 0 1 1 1 1 Nucleoside triphosphatase I C-terminal tRNA-synt_1f PF01921.18 EFA81183.1 - 0.09 11.7 0.2 0.2 10.5 0.2 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (K) PSI_integrin PF17205.3 EFA81183.1 - 0.87 9.4 17.6 2.9 7.7 0.0 4.2 4 0 0 4 4 4 0 Integrin plexin domain DUF333 PF03891.15 EFA81183.1 - 2.2 8.6 9.0 40 4.5 0.3 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF333) PSI PF01437.25 EFA81183.1 - 8.1 7.1 19.2 1.4e+02 3.1 0.8 4.0 2 1 1 3 3 3 0 Plexin repeat Ebp2 PF05890.12 EFA81184.1 - 3.7e-74 249.7 27.3 3.7e-74 249.7 27.3 2.4 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 AJAP1_PANP_C PF15298.6 EFA81184.1 - 1.9 8.6 7.2 3.9 7.6 7.2 1.5 1 0 0 1 1 1 0 AJAP1/PANP C-terminus AP-5_subunit_s1 PF15001.6 EFA81184.1 - 7 6.6 11.9 4.7 7.2 0.1 3.6 3 0 0 3 3 3 0 AP-5 complex subunit sigma-1 Endonuclease_NS PF01223.23 EFA81185.1 - 6.4e-47 160.3 0.0 9.4e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease DUF2226 PF09987.9 EFA81185.1 - 0.0057 16.0 0.9 0.29 10.4 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2226) DUF2235 PF09994.9 EFA81185.1 - 0.24 10.7 0.9 0.27 10.6 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) SUR7 PF06687.12 EFA81186.1 - 0.0002 21.1 0.5 0.0002 21.1 0.5 1.9 2 0 0 2 2 2 1 SUR7/PalI family Amastin PF07344.11 EFA81186.1 - 0.0079 16.1 0.2 0.0079 16.1 0.2 2.1 1 1 1 2 2 2 1 Amastin surface glycoprotein CAAD PF14159.6 EFA81186.1 - 0.13 12.1 3.0 0.25 11.2 3.0 1.5 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase MARVEL PF01284.23 EFA81186.1 - 0.27 11.2 8.2 2.9 7.9 8.0 2.3 1 1 0 1 1 1 0 Membrane-associating domain DUF454 PF04304.13 EFA81186.1 - 3 7.9 12.5 6.9 6.7 12.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF454) DUF2207 PF09972.9 EFA81186.1 - 6.7 5.3 8.8 9 4.9 8.8 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PIP5K PF01504.18 EFA81187.1 - 6e-95 317.6 0.2 6e-95 317.6 0.2 2.6 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase V-SNARE_C PF12352.8 EFA81189.1 - 1.9e-15 56.9 1.9 4.3e-15 55.7 1.9 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFA81189.1 - 1.4e-07 31.3 2.3 4.7e-07 29.6 0.2 2.3 2 0 0 2 2 2 1 Sec20 DUF4830 PF16112.5 EFA81189.1 - 0.029 14.8 1.0 0.25 11.8 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4830) MtrB PF05440.12 EFA81189.1 - 0.091 13.2 0.9 13 6.3 0.1 2.7 2 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B Rx_N PF18052.1 EFA81189.1 - 0.091 13.0 1.5 2 8.7 0.1 2.4 1 1 1 2 2 2 0 Rx N-terminal domain Snapin_Pallidin PF14712.6 EFA81189.1 - 0.092 13.2 7.3 0.22 11.9 0.4 2.5 2 1 0 2 2 2 0 Snapin/Pallidin DUF1899 PF08953.11 EFA81190.1 - 2.8e-40 136.0 4.5 2.9e-19 68.7 0.1 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EFA81190.1 - 1.9e-33 114.1 3.0 7.9e-18 64.1 0.8 2.5 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.32 EFA81190.1 - 5.2e-25 87.2 16.3 2e-05 25.3 0.0 8.8 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA81190.1 - 1.2e-10 41.6 0.3 0.3 11.4 0.0 5.5 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S9_N PF02897.15 EFA81190.1 - 0.0071 15.2 0.3 0.97 8.2 0.0 2.8 2 1 0 3 3 3 1 Prolyl oligopeptidase, N-terminal beta-propeller domain eIF2A PF08662.11 EFA81190.1 - 0.015 15.2 1.7 14 5.5 0.0 3.8 4 0 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EFA81190.1 - 0.05 12.2 7.3 0.34 9.5 0.0 3.7 3 1 1 4 4 4 0 Nucleoporin Nup120/160 PH PF00169.29 EFA81191.1 - 8e-11 42.4 0.3 8e-11 42.4 0.3 1.7 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA81191.1 - 0.055 13.7 0.5 0.15 12.4 0.1 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain PH PF00169.29 EFA81192.1 - 1.3e-10 41.7 0.2 1.8e-10 41.3 0.2 1.1 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA81192.1 - 1.2e-05 25.6 0.1 1.4e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGAP PF00620.27 EFA81193.1 - 8.3e-27 93.9 1.2 4.1e-25 88.4 0.2 2.5 2 0 0 2 2 2 2 RhoGAP domain RE_Alw26IDE PF09665.10 EFA81193.1 - 0.00068 18.9 0.4 0.0013 18.0 0.4 1.4 1 0 0 1 1 1 1 Type II restriction endonuclease (RE_Alw26IDE) SinI PF08671.10 EFA81193.1 - 0.072 12.9 0.1 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 Anti-repressor SinI Ank_2 PF12796.7 EFA81194.1 - 2.3e-33 114.6 15.8 1.4e-08 35.2 0.5 6.8 2 1 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81194.1 - 1.5e-30 105.2 18.9 3.4e-05 24.3 0.1 10.7 3 2 10 13 13 13 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81194.1 - 3.6e-28 97.3 17.9 0.00043 20.5 0.1 12.5 3 1 10 13 13 13 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81194.1 - 9.7e-19 65.5 7.2 1 10.1 0.0 12.6 11 2 3 14 14 13 3 Ankyrin repeat DUF5049 PF16468.5 EFA81194.1 - 5.6e-05 22.9 0.1 26 4.8 0.0 6.8 5 1 2 7 7 7 0 Domain of unknown function (DUF5049) DUF4411 PF14367.6 EFA81194.1 - 0.00039 20.4 2.1 4.6 7.1 0.0 3.8 1 1 0 3 3 3 2 Domain of unknown function (DUF4411) DUF3322 PF11795.8 EFA81194.1 - 0.016 15.3 0.1 12 5.9 0.0 4.2 3 2 1 4 4 4 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Ank PF00023.30 EFA81194.1 - 0.025 15.0 6.6 32 5.2 0.4 6.7 6 3 1 7 7 6 0 Ankyrin repeat DUF3447 PF11929.8 EFA81194.1 - 0.037 14.0 6.5 5.2 7.1 0.2 4.9 3 2 0 4 4 4 0 Domain of unknown function (DUF3447) AbiEi_3_N PF17194.4 EFA81194.1 - 0.07 13.2 0.2 2.4 8.2 0.0 3.1 2 2 2 4 4 4 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain ENTH PF01417.20 EFA81194.1 - 0.1 12.7 3.3 24 5.0 0.1 5.2 4 3 3 7 7 7 0 ENTH domain FOLN PF09289.10 EFA81196.1 - 0.037 14.2 4.2 0.037 14.2 4.2 7.2 7 1 1 8 8 8 0 Follistatin/Osteonectin-like EGF domain SPX PF03105.19 EFA81196.1 - 0.055 13.4 3.6 0.063 13.2 3.6 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 EFA81196.1 - 0.19 10.3 9.4 0.24 9.9 9.4 1.0 1 0 0 1 1 1 0 Macoilin family DUF4614 PF15391.6 EFA81196.1 - 0.44 10.5 12.3 0.66 10.0 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 EFA81196.1 - 0.81 8.5 7.6 1.1 8.1 7.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain GET2 PF08690.10 EFA81198.1 - 0.42 10.2 2.5 0.78 9.4 2.5 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 BRD4_CDT PF17105.5 EFA81198.1 - 6.5 6.4 7.6 17 5.1 7.6 1.7 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 tRNA-synt_1 PF00133.22 EFA81199.1 - 3.9e-187 623.2 0.0 4.1e-186 619.8 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFA81199.1 - 1.4e-29 103.0 1.5 3.4e-29 101.8 1.5 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFA81199.1 - 5.7e-19 68.1 0.6 2.2e-09 36.5 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFA81199.1 - 1.1e-08 34.8 0.0 3.7e-05 23.3 0.0 2.8 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EFA81199.1 - 7.9e-05 22.2 0.0 0.045 13.1 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1b PF00579.25 EFA81199.1 - 0.048 13.0 1.6 0.15 11.3 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) RCC1 PF00415.18 EFA81200.1 - 7e-37 125.8 6.8 1.2e-10 41.9 0.2 7.9 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA81200.1 - 2.6e-22 78.1 16.7 2.7e-05 23.8 0.1 6.9 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat PRKCSH_1 PF13015.6 EFA81201.1 - 1.9e-06 27.6 0.0 3.1e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Med20 PF08612.11 EFA81202.1 - 5.2e-21 75.0 0.0 9.7e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex PhoQ_Sensor PF08918.10 EFA81202.1 - 0.17 11.8 3.1 0.23 11.3 0.0 2.6 3 0 0 3 3 3 0 PhoQ Sensor Laminin_EGF PF00053.24 EFA81202.1 - 4 7.7 12.3 4.2e+02 1.2 12.3 2.6 1 1 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.13 EFA81202.1 - 6.9 7.1 13.9 0.43 11.0 5.4 2.9 1 1 1 2 2 2 0 EGF-like domain RR_TM4-6 PF06459.12 EFA81205.1 - 0.0027 17.6 17.1 0.0041 17.0 17.1 1.4 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EFA81205.1 - 0.0047 15.3 18.2 0.0063 14.9 18.2 1.2 1 0 0 1 1 1 1 CDC45-like protein DUF2151 PF10221.9 EFA81205.1 - 0.0074 15.0 18.1 0.01 14.4 18.1 1.2 1 0 0 1 1 1 1 Cell cycle and development regulator SID-1_RNA_chan PF13965.6 EFA81205.1 - 0.012 14.1 11.9 0.015 13.7 11.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2828 PF11443.8 EFA81205.1 - 0.012 13.7 14.9 0.016 13.3 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ALMT PF11744.8 EFA81205.1 - 0.091 11.6 10.5 0.11 11.3 10.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 EFA81205.1 - 0.36 10.3 25.1 0.78 9.2 25.1 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 DDHD PF02862.17 EFA81205.1 - 0.36 10.9 13.4 0.41 10.8 11.1 2.0 2 0 0 2 2 2 0 DDHD domain DUF913 PF06025.12 EFA81205.1 - 0.39 9.6 10.0 0.091 11.7 7.0 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Rtf2 PF04641.12 EFA81205.1 - 0.54 9.6 27.2 0.93 8.8 27.2 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger NPR3 PF03666.13 EFA81205.1 - 0.65 8.7 25.4 1.2 7.9 25.4 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GPCR_chapero_1 PF11904.8 EFA81205.1 - 0.93 8.9 20.1 1.3 8.4 20.1 1.5 1 1 0 1 1 1 0 GPCR-chaperone RP-C_C PF11800.8 EFA81205.1 - 1.4 8.9 10.6 2.6 8.1 10.6 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 EFA81205.1 - 1.5 7.5 21.2 2.5 6.8 21.2 1.3 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EFA81205.1 - 1.5 8.8 13.6 2.6 8.0 13.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BORG_CEP PF14957.6 EFA81205.1 - 1.7 9.8 12.9 2.7 9.2 10.4 2.2 2 0 0 2 2 2 0 Cdc42 effector DUF789 PF05623.12 EFA81205.1 - 1.8 8.1 15.5 2.6 7.7 13.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF789) Borrelia_P83 PF05262.11 EFA81205.1 - 2 6.8 31.3 3 6.2 31.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CLN3 PF02487.17 EFA81205.1 - 2.4 7.1 11.4 4.2 6.3 11.4 1.4 1 0 0 1 1 1 0 CLN3 protein TALPID3 PF15324.6 EFA81205.1 - 3.6 5.1 25.4 4.9 4.7 25.4 1.1 1 0 0 1 1 1 0 Hedgehog signalling target AAA_11 PF13086.6 EFA81205.1 - 3.7 7.3 20.7 5.6 6.7 20.7 1.3 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpc4 PF05132.14 EFA81205.1 - 4.7 7.6 19.2 10 6.5 19.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 BPL_N PF09825.9 EFA81205.1 - 5.2 6.0 11.9 7.2 5.6 11.9 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF4604 PF15377.6 EFA81205.1 - 6 7.3 34.4 12 6.3 34.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) ABC2_membrane PF01061.24 EFA81206.1 - 8.7e-35 120.0 24.8 1.3e-34 119.4 24.8 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFA81206.1 - 1.3e-27 97.0 0.0 2.6e-27 96.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA81206.1 - 9.7e-08 32.2 0.0 0.0085 15.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFA81206.1 - 0.00045 20.6 0.0 0.001 19.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 EFA81206.1 - 0.0022 17.5 0.1 0.79 9.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFA81206.1 - 0.0024 18.1 0.0 0.01 16.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFA81206.1 - 0.003 17.3 0.1 0.0068 16.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 EFA81206.1 - 0.005 16.8 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EFA81206.1 - 0.0079 16.7 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFA81206.1 - 0.011 15.4 0.1 0.032 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFA81206.1 - 0.02 15.2 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFA81206.1 - 0.026 15.0 0.1 0.048 14.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFA81206.1 - 0.043 14.2 0.0 0.62 10.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFA81206.1 - 0.056 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 EFA81206.1 - 0.056 12.9 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 recA bacterial DNA recombination protein DUF4516 PF14990.6 EFA81206.1 - 0.067 12.9 1.3 13 5.7 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) RsgA_GTPase PF03193.16 EFA81206.1 - 0.071 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase cobW PF02492.19 EFA81206.1 - 0.087 12.4 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFA81206.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain SQHop_cyclase_C PF13243.6 EFA81207.1 - 1.6e-65 221.3 0.0 5.6e-57 193.3 0.0 2.7 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EFA81207.1 - 3.5e-50 170.7 0.1 3.6e-43 147.7 0.0 4.4 2 1 2 5 5 5 5 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EFA81207.1 - 9.7e-43 143.6 2.5 6.4e-12 45.0 0.0 6.2 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EFA81207.1 - 2.5e-06 26.8 0.3 3.4 6.6 0.0 5.0 4 1 2 6 6 6 3 A-macroglobulin TED domain Pec_lyase PF09492.10 EFA81207.1 - 5.7e-06 25.9 0.1 0.13 11.6 0.0 4.1 3 1 0 4 4 4 2 Pectic acid lyase Tweety PF04906.13 EFA81208.1 - 5.8e-09 35.1 2.2 5e-06 25.4 1.3 2.3 2 0 0 2 2 2 2 Tweety DUF2207 PF09972.9 EFA81208.1 - 0.00012 21.0 0.1 0.073 11.8 0.0 2.1 1 1 1 2 2 2 2 Predicted membrane protein (DUF2207) CHASE9 PF17153.4 EFA81208.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Periplasmic sensor domain, extracellular DUF1634 PF07843.11 EFA81208.1 - 0.21 11.7 5.0 2.4 8.3 0.5 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1634) MASE1 PF05231.14 EFA81208.1 - 0.44 9.6 7.6 1.4 8.0 0.0 3.0 3 0 0 3 3 3 0 MASE1 PRA1 PF03208.19 EFA81208.1 - 1.9 8.1 5.8 0.53 9.9 0.1 2.5 3 1 0 3 3 3 0 PRA1 family protein Ta0938 PF11494.8 EFA81209.1 - 0.026 14.8 0.2 0.033 14.5 0.2 1.3 1 0 0 1 1 1 0 Ta0938 Gtr1_RagA PF04670.12 EFA81210.1 - 8e-103 342.8 2.5 8e-103 342.8 2.5 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ins134_P3_kin PF05770.11 EFA81210.1 - 4.2e-49 166.8 0.3 8.5e-49 165.8 0.3 1.5 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Roc PF08477.13 EFA81210.1 - 8.2e-10 38.9 0.8 2.9e-09 37.2 0.0 2.4 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA81210.1 - 7.6e-09 35.4 0.0 2.1e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFA81210.1 - 4.4e-07 29.5 0.1 9e-07 28.5 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA81210.1 - 4.7e-07 29.9 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ins134_P3_kin_N PF17927.1 EFA81210.1 - 8.2e-06 26.1 0.1 4.5e-05 23.8 0.0 2.5 2 1 0 2 2 2 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain SRPRB PF09439.10 EFA81210.1 - 0.023 14.1 0.1 0.045 13.2 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Spectrin_like PF18373.1 EFA81210.1 - 0.11 12.6 0.8 11 6.1 0.1 3.0 3 0 0 3 3 3 0 Spectrin like domain TMPIT PF07851.13 EFA81211.1 - 1.5e-38 132.9 12.8 1.5e-33 116.5 2.6 2.0 1 1 1 2 2 2 2 TMPIT-like protein Rogdi_lz PF10259.9 EFA81211.1 - 0.0044 16.5 0.2 0.0054 16.2 0.2 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein DUF2730 PF10805.8 EFA81211.1 - 0.072 13.2 0.8 0.3 11.2 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) DUF599 PF04654.12 EFA81211.1 - 0.1 12.0 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF599 PUL PF08324.11 EFA81212.1 - 2e-48 165.0 1.8 3.5e-48 164.3 1.8 1.3 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EFA81212.1 - 2.1e-39 134.8 0.0 4.7e-39 133.6 0.0 1.6 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EFA81212.1 - 0.0028 18.0 0.4 0.022 15.0 0.1 2.2 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Glyco_hydro_9 PF00759.19 EFA81213.1 - 3.3e-128 428.6 13.9 3.9e-128 428.4 13.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 CBM49 PF09478.10 EFA81213.1 - 4.8e-19 68.4 2.5 1e-18 67.4 2.5 1.5 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Wzy_C PF04932.15 EFA81214.1 - 0.015 14.9 0.3 0.015 14.9 0.3 1.5 2 0 0 2 2 2 0 O-Antigen ligase MscL PF01741.18 EFA81214.1 - 0.61 10.4 4.2 4.9 7.5 3.1 2.1 1 1 1 2 2 2 0 Large-conductance mechanosensitive channel, MscL PH PF00169.29 EFA81215.1 - 8.9e-11 42.2 0.0 3.5e-10 40.3 0.0 2.1 1 0 0 1 1 1 1 PH domain GAS2 PF02187.17 EFA81215.1 - 2.5e-07 30.7 0.0 1.3e-06 28.4 0.0 2.3 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain ERM PF00769.19 EFA81215.1 - 0.023 14.5 41.4 0.0073 16.2 30.9 2.8 2 1 0 2 2 2 0 Ezrin/radixin/moesin family Mating_N PF12731.7 EFA81215.1 - 0.42 10.7 5.6 0.28 11.3 0.3 3.3 3 0 0 3 3 3 0 Mating-type protein beta 1 kleA_kleC PF17383.2 EFA81215.1 - 0.85 10.0 7.7 23 5.4 0.0 3.2 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A Ras PF00071.22 EFA81216.1 - 4.4e-59 198.7 0.0 5.1e-59 198.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA81216.1 - 1.1e-20 74.0 0.0 1.5e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA81216.1 - 2.1e-09 37.1 0.0 2.5e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA81216.1 - 4.4e-06 26.4 0.3 3.8e-05 23.3 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA81216.1 - 8.4e-05 22.6 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA81216.1 - 0.00013 21.9 0.2 0.55 10.1 0.0 2.4 1 1 2 3 3 3 2 RsgA GTPase ATP_bind_1 PF03029.17 EFA81216.1 - 0.0086 15.9 0.8 0.096 12.5 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 EFA81216.1 - 0.038 13.3 0.0 0.071 12.4 0.0 1.5 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 EFA81216.1 - 0.048 13.2 0.0 0.24 10.9 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B ParA PF10609.9 EFA81216.1 - 0.19 11.1 0.2 0.78 9.1 0.1 1.8 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase p450 PF00067.22 EFA81217.1 - 2.8e-162 540.7 0.7 1.4e-100 337.3 0.0 3.0 2 1 1 3 3 3 3 Cytochrome P450 p450 PF00067.22 EFA81218.1 - 1.9e-102 343.4 0.0 2.1e-102 343.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Erg28 PF03694.13 EFA81219.1 - 4.4e-22 78.6 5.1 7.7e-22 77.8 5.1 1.4 1 0 0 1 1 1 1 Erg28 like protein p450 PF00067.22 EFA81221.1 - 4.8e-97 325.6 0.0 1.2e-96 324.3 0.0 1.7 1 0 0 1 1 1 1 Cytochrome P450 RhoGEF PF00621.20 EFA81221.1 - 2.6e-48 164.7 4.8 7.2e-42 143.7 3.0 3.2 2 0 0 2 2 2 2 RhoGEF domain IQ PF00612.27 EFA81221.1 - 0.00086 18.9 1.0 0.002 17.8 1.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Mucin PF01456.17 EFA81221.1 - 0.47 10.4 27.1 0.84 9.6 9.0 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein Adaptin_N PF01602.20 EFA81222.1 - 6.3e-84 282.4 11.3 6.3e-84 282.4 11.3 1.4 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EFA81222.1 - 4.9e-52 175.3 0.2 2e-51 173.3 0.2 2.2 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EFA81222.1 - 1.5e-47 161.0 0.8 6.3e-47 159.0 0.1 2.4 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 EFA81222.1 - 3.5e-07 30.4 12.1 1.3e-05 25.3 0.1 3.7 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA81222.1 - 3.9e-05 23.9 0.0 0.0058 17.0 0.0 3.5 2 2 1 3 3 3 2 HEAT repeats Coatomer_g_Cpla PF16381.5 EFA81222.1 - 0.00062 19.9 0.0 0.0034 17.5 0.0 2.3 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 EFA81222.1 - 0.0014 18.7 0.2 7.9 7.0 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 EFA81222.1 - 0.13 12.8 0.0 60 4.3 0.0 3.7 4 0 0 4 4 4 0 HEAT-like repeat TPD PF14811.6 EFA81223.1 - 4.3e-48 162.6 0.1 8.8e-48 161.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function TPD sequence-motif SF3b10 PF07189.11 EFA81224.1 - 6.9e-36 122.2 0.0 8.3e-36 122.0 0.0 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Glyco_hydro_9 PF00759.19 EFA81225.1 - 3.9e-122 408.6 8.4 4.8e-122 408.3 8.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 OTU PF02338.19 EFA81226.1 - 1.3e-06 28.9 0.0 2.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease HNH PF01844.23 EFA81226.1 - 0.0046 17.1 0.0 0.0099 16.0 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease DUF1187 PF06688.11 EFA81226.1 - 0.0055 17.0 0.3 0.011 16.0 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1187) TBK1_ULD PF18396.1 EFA81226.1 - 0.016 15.1 0.0 0.048 13.6 0.0 1.8 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain DUF2738 PF10927.8 EFA81226.1 - 0.091 11.8 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) Glyco_hydro_9 PF00759.19 EFA81227.1 - 7.2e-105 351.8 8.6 2.1e-104 350.2 8.6 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 9 CBM49 PF09478.10 EFA81227.1 - 1.7e-18 66.7 0.5 3.7e-18 65.6 0.5 1.5 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Nucleo_P87 PF07267.11 EFA81227.1 - 0.014 14.3 13.1 0.019 13.8 13.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SOG2 PF10428.9 EFA81227.1 - 4.8 6.3 11.5 6.5 5.8 11.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein KAR9 PF08580.10 EFA81227.1 - 7.4 5.0 8.6 9.7 4.6 8.6 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 TMEM40 PF15817.5 EFA81228.1 - 0.14 11.9 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 40 family Methyltransf_23 PF13489.6 EFA81229.1 - 4.9e-20 72.0 0.0 6.1e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA81229.1 - 8.1e-13 48.4 0.0 9.7e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA81229.1 - 1.4e-12 48.1 0.0 2.5e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA81229.1 - 2.6e-10 40.9 0.0 5.5e-10 39.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA81229.1 - 4.4e-10 40.2 0.0 6.7e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA81229.1 - 1.8e-06 27.5 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF2194 PF09960.9 EFA81229.1 - 0.0012 17.4 0.0 0.0014 17.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2194) MetW PF07021.12 EFA81229.1 - 0.0049 16.5 0.0 0.52 9.9 0.0 2.2 1 1 1 2 2 2 2 Methionine biosynthesis protein MetW Methyltransf_17 PF12692.7 EFA81229.1 - 0.084 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase GidB PF02527.15 EFA81229.1 - 0.12 11.7 0.0 7.7 5.8 0.0 2.2 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G DUF2151 PF10221.9 EFA81230.1 - 1.1e-29 103.6 34.1 4.3e-19 68.6 16.4 3.2 2 1 0 3 3 3 2 Cell cycle and development regulator CNDH2_C PF16858.5 EFA81230.1 - 0.00011 22.2 0.1 0.00011 22.2 0.1 3.2 2 1 1 3 3 3 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term CENP-X PF09415.10 EFA81231.1 - 6.5e-07 29.6 1.4 1.9e-06 28.1 1.4 1.9 1 1 0 1 1 1 1 CENP-S associating Centromere protein X Herpes_capsid PF06112.11 EFA81231.1 - 0.053 13.6 5.9 0.14 12.2 0.4 2.2 1 1 1 2 2 2 0 Gammaherpesvirus capsid protein Macro PF01661.21 EFA81232.1 - 9.2e-33 112.8 0.3 2.1e-32 111.6 0.3 1.7 1 0 0 1 1 1 1 Macro domain WWE PF02825.20 EFA81232.1 - 3.2e-27 94.9 19.8 1e-09 38.9 0.1 4.7 4 0 0 4 4 4 3 WWE domain TFIIA PF03153.13 EFA81232.1 - 4.6 7.1 46.3 0.014 15.4 10.3 3.4 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit PNP_UDP_1 PF01048.20 EFA81233.1 - 3.2e-32 111.7 0.0 3.7e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Lyase_aromatic PF00221.19 EFA81234.1 - 6.9e-186 618.4 0.3 8.5e-186 618.1 0.3 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase Cnn_1N PF07989.11 EFA81234.1 - 0.02 15.0 2.0 0.044 13.9 2.0 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF724 PF05266.14 EFA81234.1 - 0.058 13.2 0.4 0.11 12.4 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) IFP_35_N PF07334.13 EFA81234.1 - 0.086 12.9 1.3 0.24 11.5 1.3 1.7 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus NUDE_C PF04880.13 EFA81234.1 - 0.35 11.3 3.8 0.13 12.7 0.9 1.7 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Ank_2 PF12796.7 EFA81235.1 - 5.5e-07 30.1 0.0 0.0051 17.4 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81235.1 - 0.051 14.2 0.1 9.7 6.9 0.0 3.7 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81235.1 - 0.052 14.1 0.0 1e+02 4.0 0.0 4.7 4 0 0 4 4 4 0 Ankyrin repeat DUF3447 PF11929.8 EFA81235.1 - 0.11 12.4 11.9 1.5 8.8 0.4 4.3 3 3 0 3 3 3 0 Domain of unknown function (DUF3447) DUF241 PF03087.14 EFA81235.1 - 0.14 12.0 0.1 0.91 9.3 0.0 2.0 2 0 0 2 2 2 0 Arabidopsis protein of unknown function Cyclin_N PF00134.23 EFA81236.1 - 0.0013 18.5 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Xpo1 PF08389.12 EFA81236.1 - 0.012 15.7 0.2 0.032 14.3 0.1 1.8 2 0 0 2 2 2 0 Exportin 1-like protein Cyclin PF08613.11 EFA81236.1 - 0.013 15.8 0.1 0.024 15.0 0.1 1.5 1 0 0 1 1 1 0 Cyclin GWT1 PF06423.12 EFA81238.1 - 0.005 17.0 0.8 0.0054 16.9 0.8 1.0 1 0 0 1 1 1 1 GWT1 DUF2053 PF09767.9 EFA81238.1 - 0.013 15.6 0.3 0.016 15.4 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2053) NEMP PF10225.9 EFA81239.1 - 0.86 9.2 3.0 2.1 7.9 3.0 1.6 1 0 0 1 1 1 0 NEMP family Exonuc_VII_L PF02601.15 EFA81239.1 - 3.3 7.2 12.5 0.11 12.0 1.5 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit HTS PF04204.16 EFA81240.1 - 0.032 13.2 4.5 0.046 12.6 4.5 1.2 1 0 0 1 1 1 0 Homoserine O-succinyltransferase End3 PF12761.7 EFA81240.1 - 1.2 9.3 29.8 1.4 9.0 2.6 2.3 1 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Uso1_p115_C PF04871.13 EFA81240.1 - 9.2 6.6 32.5 0.035 14.5 6.3 2.9 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CK_II_beta PF01214.18 EFA81242.1 - 0.0051 16.6 0.2 0.0058 16.5 0.2 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HNH_2 PF13391.6 EFA81242.1 - 0.1 12.7 0.2 0.73 10.0 0.0 2.3 1 1 1 2 2 2 0 HNH endonuclease DUF3179 PF11376.8 EFA81242.1 - 0.16 11.3 0.2 0.19 11.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3179) ATP_synt_H PF05493.13 EFA81243.1 - 8.1e-15 55.0 8.2 1.1e-14 54.6 8.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit H ABC2_membrane_2 PF12679.7 EFA81243.1 - 0.16 11.2 2.5 0.19 11.0 2.5 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Adeno_E3_CR2 PF02439.15 EFA81243.1 - 0.52 10.1 4.8 4.2 7.2 0.9 2.2 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 EAR PF07897.11 EFA81244.1 - 0.081 12.6 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression DUF4235 PF14019.6 EFA81244.1 - 0.14 12.2 0.4 0.57 10.3 0.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF4235) DUF2621 PF11084.8 EFA81244.1 - 0.57 10.2 1.8 12 5.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2621) Kelch_6 PF13964.6 EFA81245.1 - 9.9e-10 38.4 5.7 0.019 15.3 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EFA81245.1 - 2.1e-07 30.8 0.2 0.063 13.3 0.0 4.1 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA81245.1 - 0.00013 21.9 1.7 0.44 10.6 0.2 3.6 3 0 0 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA81245.1 - 0.0021 18.1 5.7 0.0021 18.1 5.7 2.4 2 0 0 2 2 2 1 B-box zinc finger Kelch_1 PF01344.25 EFA81245.1 - 0.011 15.3 5.8 4.2 7.1 0.0 4.4 4 0 0 4 4 4 0 Kelch motif Pentapeptide_3 PF13576.6 EFA81246.1 - 6 7.1 14.2 8.5 6.6 0.1 5.8 6 1 0 6 6 6 0 Pentapeptide repeats (9 copies) Zn_ribbon_17 PF17120.5 EFA81247.1 - 1.3e-07 31.1 10.7 1.3e-07 31.1 10.7 2.0 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 EFA81247.1 - 1.7e-05 25.1 6.2 1.7e-05 25.1 6.2 3.7 2 2 2 4 4 4 1 Zinc-ribbon like family WD40 PF00400.32 EFA81247.1 - 0.00049 20.8 0.2 1.3 10.0 0.0 4.5 3 0 0 3 3 3 1 WD domain, G-beta repeat DZR PF12773.7 EFA81247.1 - 4.1 7.5 16.0 0.36 10.9 10.9 1.9 2 0 0 2 2 2 0 Double zinc ribbon Mpp10 PF04006.12 EFA81248.1 - 1.5e-146 489.4 91.8 1.5e-146 489.4 91.8 2.2 2 1 0 2 2 2 1 Mpp10 protein ADK PF00406.22 EFA81249.1 - 1.9e-05 24.8 0.6 7.9e-05 22.8 0.1 2.3 2 1 0 2 2 2 1 Adenylate kinase Macoilin PF09726.9 EFA81249.1 - 0.0049 15.5 14.3 0.0056 15.3 14.3 1.2 1 0 0 1 1 1 1 Macoilin family Pox_Ag35 PF03286.14 EFA81249.1 - 0.16 11.7 9.4 0.36 10.6 9.4 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 EFA81249.1 - 0.53 9.6 11.0 0.86 8.9 11.0 1.2 1 0 0 1 1 1 0 NOA36 protein Coilin_N PF15862.5 EFA81249.1 - 0.57 10.0 0.0 0.57 10.0 0.0 3.4 2 1 1 3 3 3 0 Coilin N-terminus SWI-SNF_Ssr4 PF08549.10 EFA81249.1 - 0.86 8.2 15.0 1.3 7.6 15.0 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Presenilin PF01080.17 EFA81249.1 - 1.4 7.6 14.1 1.9 7.2 14.1 1.2 1 0 0 1 1 1 0 Presenilin Brix PF04427.18 EFA81251.1 - 1.4e-42 146.0 0.1 2.4e-42 145.2 0.1 1.4 1 0 0 1 1 1 1 Brix domain DUF2120 PF09893.9 EFA81251.1 - 0.038 14.1 0.1 0.27 11.3 0.0 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) FNIP PF05725.12 EFA81252.1 - 8e-16 57.9 33.3 0.0055 16.8 0.3 9.8 5 5 4 9 9 9 9 FNIP Repeat DUF5103 PF17116.5 EFA81252.1 - 0.057 12.7 0.4 0.091 12.0 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5103) F-box PF00646.33 EFA81252.1 - 0.24 11.3 2.2 22 5.1 0.0 3.6 3 0 0 3 3 3 0 F-box domain Macoilin PF09726.9 EFA81253.1 - 0.0014 17.3 18.2 0.002 16.8 18.2 1.1 1 0 0 1 1 1 1 Macoilin family HAUS-augmin3 PF14932.6 EFA81253.1 - 0.018 14.6 14.1 0.032 13.8 14.1 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 FAM76 PF16046.5 EFA81253.1 - 0.18 11.1 19.6 0.35 10.2 19.6 1.5 1 0 0 1 1 1 0 FAM76 protein Laminin_II PF06009.12 EFA81253.1 - 0.28 11.2 15.7 0.29 11.1 8.5 2.4 1 1 1 2 2 2 0 Laminin Domain II DUF724 PF05266.14 EFA81253.1 - 0.56 10.0 19.7 0.51 10.1 16.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF489 PF04356.12 EFA81253.1 - 0.63 10.0 5.4 0.51 10.3 3.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Occludin_ELL PF07303.13 EFA81253.1 - 0.68 10.7 16.6 0.54 11.0 10.6 3.0 1 1 2 3 3 3 0 Occludin homology domain DUF4349 PF14257.6 EFA81253.1 - 1.2 8.6 9.3 0.039 13.4 2.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) KELK PF15796.5 EFA81253.1 - 1.3 9.6 25.9 0.79 10.2 17.4 3.3 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase COG2 PF06148.11 EFA81253.1 - 1.3 9.1 12.4 0.58 10.3 6.1 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Pox_A_type_inc PF04508.12 EFA81253.1 - 1.4 8.9 4.4 0.43 10.5 0.5 2.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat GAS PF13851.6 EFA81253.1 - 2.1 7.6 25.2 3.8 6.8 25.2 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 EFA81253.1 - 3 8.3 22.5 1.1 9.7 16.9 2.6 2 1 1 3 3 3 0 Centromere protein H (CENP-H) zf-C4H2 PF10146.9 EFA81253.1 - 3.1 8.1 28.6 0.31 11.3 23.1 2.0 1 1 1 2 2 2 0 Zinc finger-containing protein LMBR1 PF04791.16 EFA81253.1 - 3.9 6.3 8.3 5 5.9 8.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ATG16 PF08614.11 EFA81253.1 - 4.6 7.4 32.8 0.084 13.1 21.2 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) FUSC PF04632.12 EFA81253.1 - 5.2 5.5 4.2 13 4.1 4.2 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family APG6_N PF17675.1 EFA81253.1 - 7.9 7.0 31.3 0.082 13.4 21.4 2.3 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF5082 PF16888.5 EFA81253.1 - 8.5 6.7 23.9 0.098 12.9 15.6 2.0 3 0 0 3 3 2 0 Domain of unknown function (DUF5082) LRR_4 PF12799.7 EFA81254.1 - 5.6e-17 61.6 8.5 5.3e-08 33.0 0.6 3.3 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA81254.1 - 5.8e-14 51.6 6.8 2.9e-07 30.2 0.6 2.4 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFA81254.1 - 3.9e-06 26.7 4.1 1.2 9.9 0.8 4.7 3 1 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 EFA81254.1 - 0.0052 16.7 6.9 0.56 10.4 0.2 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_9 PF14580.6 EFA81254.1 - 0.15 11.6 2.8 0.28 10.6 1.4 1.8 1 1 1 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.6 EFA81255.1 - 8.1e-29 99.2 30.9 3.3e-09 36.4 0.3 3.8 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFA81255.1 - 4.3e-24 84.2 29.5 2e-06 28.0 1.9 4.2 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA81255.1 - 1.7e-09 36.9 8.6 2.2 9.2 0.3 6.7 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 EFA81255.1 - 0.71 10.1 23.6 0.98 9.6 0.2 6.3 7 0 0 7 7 7 0 Leucine Rich repeat LMBR1 PF04791.16 EFA81256.1 - 2.4e-82 277.5 9.4 4e-61 207.5 0.3 2.4 3 0 0 3 3 3 2 LMBR1-like membrane protein SDP_N PF12278.8 EFA81256.1 - 0.072 13.2 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 Sex determination protein N terminal EMC3_TMCO1 PF01956.16 EFA81256.1 - 0.13 12.0 1.4 0.4 10.4 0.0 2.5 2 1 1 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Neur_chan_memb PF02932.16 EFA81257.1 - 0.12 12.4 5.3 0.16 12.0 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EFA81257.1 - 0.16 10.7 7.5 0.19 10.5 7.5 1.3 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 EFA81257.1 - 0.21 10.6 6.1 0.23 10.5 6.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein ABC_membrane_3 PF13748.6 EFA81257.1 - 0.24 10.6 1.8 0.39 9.9 1.8 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region Tetraspanin PF00335.20 EFA81257.1 - 0.36 10.5 2.3 0.46 10.2 2.3 1.1 1 0 0 1 1 1 0 Tetraspanin family Zip PF02535.22 EFA81257.1 - 0.57 9.3 11.1 0.75 8.9 11.1 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter IMUP PF15761.5 EFA81257.1 - 5.4 7.7 19.6 2.1 9.1 15.7 2.0 2 0 0 2 2 2 0 Immortalisation up-regulated protein ETRAMP PF09716.10 EFA81257.1 - 6 7.0 8.2 49 4.1 8.3 2.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PSI_integrin PF17205.3 EFA81258.1 - 0.0091 15.7 15.5 1 9.2 0.1 3.8 3 2 0 3 3 3 3 Integrin plexin domain zf-BED PF02892.15 EFA81258.1 - 0.041 13.9 1.6 5 7.2 0.0 3.0 3 0 0 3 3 3 0 BED zinc finger PSI PF01437.25 EFA81258.1 - 0.13 12.9 11.5 2.3 8.8 4.6 2.6 1 1 1 2 2 2 0 Plexin repeat zf-CHCC PF10276.9 EFA81258.1 - 1.1 9.3 6.8 34 4.6 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger domain DUF333 PF03891.15 EFA81258.1 - 1.6 9.0 6.3 10 6.4 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF333) RecR PF02132.15 EFA81258.1 - 6 6.5 11.6 17 5.0 0.3 3.6 4 0 0 4 4 4 0 RecR protein CH PF00307.31 EFA81260.1 - 4e-09 36.6 1.9 2.4e-05 24.5 0.1 3.2 3 0 0 3 3 3 2 Calponin homology (CH) domain Methyltransf_2 PF00891.18 EFA81261.1 - 1.4e-11 44.1 0.0 2e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA81261.1 - 4.6e-06 26.5 0.0 9.1e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain Rrf2 PF02082.20 EFA81261.1 - 0.0012 19.2 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator LSM14 PF12701.7 EFA81263.1 - 8.2e-28 96.3 0.3 2.1e-27 95.0 0.3 1.8 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EFA81263.1 - 1.4e-08 34.8 0.1 4.3e-08 33.2 0.1 1.9 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 EFA81263.1 - 2.1e-08 35.0 1.4 2.1e-08 35.0 1.4 5.6 5 1 1 6 6 6 1 FDF domain Med12 PF09497.10 EFA81264.1 - 5.2e-18 65.1 0.2 2.2e-17 63.1 0.1 2.2 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 EFA81264.1 - 3.1e-06 26.3 8.0 0.00022 20.2 0.6 6.1 4 1 2 6 6 6 3 Eukaryotic Mediator 12 subunit domain SUIM_assoc PF16619.5 EFA81264.1 - 0.0069 16.4 0.9 0.0069 16.4 0.9 6.9 5 2 1 6 6 6 1 Unstructured region C-term to UIM in Ataxin3 PH PF00169.29 EFA81265.1 - 1.5e-18 67.2 0.5 1.5e-18 67.2 0.5 2.7 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 EFA81265.1 - 7.5e-08 32.7 1.4 6.1e-07 29.8 1.4 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EFA81265.1 - 8.1e-05 22.7 0.6 8.1e-05 22.7 0.6 2.0 2 0 0 2 2 2 1 PH domain TPR_12 PF13424.6 EFA81265.1 - 0.012 15.9 0.0 0.79 10.1 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat PH_9 PF15410.6 EFA81265.1 - 0.026 14.9 0.5 0.86 10.0 0.1 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain SKG6 PF08693.10 EFA81266.1 - 0.0089 15.4 0.6 0.018 14.4 0.6 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Frag1 PF10277.9 EFA81266.1 - 0.085 12.4 5.0 3.3 7.2 0.1 3.0 3 0 0 3 3 3 0 Frag1/DRAM/Sfk1 family Presenilin PF01080.17 EFA81267.1 - 0.00034 19.5 39.6 0.00034 19.5 39.6 1.7 2 0 0 2 2 2 1 Presenilin Dapper PF15268.6 EFA81267.1 - 0.01 14.8 39.3 0.012 14.5 39.3 1.3 1 0 0 1 1 1 0 Dapper GREB1 PF15782.5 EFA81267.1 - 1.8 5.6 40.0 2.2 5.3 40.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Proteasome PF00227.26 EFA81268.1 - 2.9e-18 66.0 0.0 3.6e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit MCU PF04678.13 EFA81269.1 - 0.037 14.1 0.8 0.041 14.0 0.8 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Ribosomal_L27e PF01777.18 EFA81269.1 - 0.054 13.9 0.8 0.063 13.6 0.8 1.1 1 0 0 1 1 1 0 Ribosomal L27e protein family Rubis-subs-bind PF09273.11 EFA81271.1 - 0.033 14.9 0.0 0.034 14.9 0.0 1.0 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding COMM_domain PF07258.14 EFA81273.1 - 9e-18 64.2 0.1 1.1e-17 63.9 0.1 1.1 1 0 0 1 1 1 1 COMM domain IF2_N PF04760.15 EFA81273.1 - 0.012 15.4 0.2 0.028 14.3 0.2 1.7 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region tRNA-synt_2 PF00152.20 EFA81274.1 - 6.2e-93 311.3 0.1 8.1e-93 310.9 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_synt_1c_R1 PF04558.15 EFA81274.1 - 6.6e-45 153.0 0.4 1e-44 152.4 0.4 1.3 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_anti-codon PF01336.25 EFA81274.1 - 9.2e-13 48.0 0.0 2e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_synt_1c_R2 PF04557.15 EFA81274.1 - 0.011 16.7 0.8 0.023 15.6 0.8 1.5 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 PWWP PF00855.17 EFA81275.1 - 0.00061 20.1 0.0 0.0018 18.6 0.0 1.8 1 0 0 1 1 1 1 PWWP domain DUF2373 PF10180.9 EFA81276.1 - 5e-21 74.3 6.7 1.8e-20 72.5 3.8 2.7 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) Macoilin PF09726.9 EFA81276.1 - 8.7 4.8 34.6 10 4.6 34.6 1.2 1 0 0 1 1 1 0 Macoilin family DUF2013 PF09431.10 EFA81277.1 - 1.2e-17 64.4 2.1 1.2e-17 64.4 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) DUF3496 PF12001.8 EFA81277.1 - 0.047 14.1 1.5 0.094 13.1 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) DUF5623 PF18536.1 EFA81277.1 - 0.066 13.5 0.1 15 5.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5623) RRN3 PF05327.11 EFA81277.1 - 0.94 7.9 8.7 0.14 10.7 5.0 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2722 PF10846.8 EFA81277.1 - 1.2 8.0 6.4 1.8 7.4 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) WAP PF00095.21 EFA81278.1 - 1.1e-13 51.3 176.2 0.04 14.3 13.6 9.1 8 1 1 9 9 9 9 WAP-type (Whey Acidic Protein) 'four-disulfide core' Conotoxin_I2 PF17557.2 EFA81278.1 - 0.16 12.1 144.1 0.25 11.5 8.2 9.5 9 0 0 9 9 9 0 I2-superfamily conotoxins ECH_1 PF00378.20 EFA81279.1 - 1.2e-37 129.6 0.0 1.4e-37 129.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFA81279.1 - 1.8e-13 50.7 0.0 2.7e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Toxin_3 PF00537.18 EFA81279.1 - 0.029 14.6 0.3 0.057 13.6 0.3 1.4 1 0 0 1 1 1 0 Scorpion toxin-like domain Peptidase_S49 PF01343.18 EFA81279.1 - 0.083 12.8 0.0 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 Peptidase family S49 Ank_2 PF12796.7 EFA81281.1 - 1.2e-22 80.3 15.4 1e-07 32.5 0.1 5.4 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81281.1 - 4.1e-22 78.3 8.4 2.5e-06 27.9 0.2 7.1 7 1 0 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81281.1 - 5.6e-18 64.8 12.9 0.0061 16.8 0.0 9.3 3 2 6 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81281.1 - 4.7e-15 54.2 7.8 0.58 10.9 0.0 10.3 9 4 4 13 13 13 2 Ankyrin repeat Ank PF00023.30 EFA81281.1 - 6.4e-06 26.4 6.2 5.5 7.6 0.0 7.5 5 2 2 7 7 7 1 Ankyrin repeat PAP_RNA-bind PF04926.15 EFA81281.1 - 0.022 14.4 5.1 0.084 12.5 5.5 1.7 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Secretin_N_2 PF07655.13 EFA81281.1 - 0.085 13.4 7.7 0.18 12.3 7.7 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain FaeA PF04703.12 EFA81281.1 - 0.11 12.9 0.2 0.41 11.1 0.1 2.0 2 0 0 2 2 2 0 FaeA-like protein Adap_comp_sub PF00928.21 EFA81282.1 - 1.1e-77 261.0 0.1 1.3e-77 260.8 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFA81282.1 - 0.00015 21.8 0.2 0.00022 21.2 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CarboxypepD_reg PF13620.6 EFA81282.1 - 0.034 14.4 0.2 1.8 8.9 0.2 2.4 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain NIDO PF06119.14 EFA81282.1 - 0.15 13.0 0.0 0.33 11.9 0.0 1.5 1 0 0 1 1 1 0 Nidogen-like SET PF00856.28 EFA81283.1 - 0.0009 19.7 1.1 0.068 13.5 0.1 3.1 2 0 0 2 2 2 1 SET domain ASH PF15780.5 EFA81283.1 - 0.019 15.2 0.7 4.6 7.5 0.0 3.3 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin GAGA_bind PF06217.12 EFA81283.1 - 0.045 14.1 7.0 0.16 12.2 7.0 1.9 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_11 PF13086.6 EFA81283.1 - 0.059 13.1 6.1 0.15 11.8 6.1 1.6 1 0 0 1 1 1 0 AAA domain DUF1682 PF07946.14 EFA81283.1 - 0.06 12.6 16.1 0.14 11.4 16.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) TTR-52 PF01060.23 EFA81283.1 - 0.24 12.1 0.6 0.91 10.3 0.0 2.3 3 0 0 3 3 3 0 Transthyretin-like family BUD22 PF09073.10 EFA81283.1 - 1.5 8.0 26.5 0.13 11.6 13.8 2.2 2 0 0 2 2 2 0 BUD22 RP-C_C PF11800.8 EFA81283.1 - 5.7 7.0 6.8 13 5.8 6.8 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region Lyase_1 PF00206.20 EFA81284.1 - 3e-114 381.6 0.0 4.1e-114 381.2 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EFA81284.1 - 1.5e-25 89.3 0.0 3.6e-25 88.1 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus TMEM144 PF07857.12 EFA81285.1 - 8e-79 265.0 14.2 9.8e-79 264.7 14.2 1.1 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EFA81285.1 - 4.5e-09 36.1 19.4 7.5e-09 35.3 8.2 2.6 2 1 1 3 3 3 2 Sugar transport protein DMT_YdcZ PF04657.13 EFA81285.1 - 0.0008 19.7 8.0 0.0008 19.7 8.0 2.6 2 2 0 2 2 2 1 Putative inner membrane exporter, YdcZ zinc_ribbon_11 PF11682.8 EFA81285.1 - 0.096 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Probable zinc-ribbon FAD_binding_3 PF01494.19 EFA81286.1 - 7e-16 58.4 0.1 8e-07 28.6 0.0 3.2 2 1 1 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 EFA81286.1 - 0.0012 19.0 0.0 0.0028 17.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFA81286.1 - 0.0039 16.5 0.0 0.0086 15.3 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EFA81286.1 - 0.0046 16.1 0.1 0.041 12.9 0.0 2.5 2 1 1 3 3 3 1 Squalene epoxidase DAO PF01266.24 EFA81286.1 - 0.18 11.3 0.0 15 5.0 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase bZIP_1 PF00170.21 EFA81287.1 - 3.9e-15 55.7 1.1 1e-14 54.4 1.1 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFA81287.1 - 3.4e-11 43.1 2.0 3.4e-11 43.1 2.0 2.4 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFA81287.1 - 0.0064 17.0 3.3 0.0064 17.0 3.3 2.1 1 1 0 1 1 1 1 bZIP Maf transcription factor AROS PF15684.5 EFA81287.1 - 2.8 8.5 8.9 0.29 11.7 1.9 2.5 3 0 0 3 3 3 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 Pkinase_Tyr PF07714.17 EFA81288.1 - 2.6e-47 161.3 0.0 4.5e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA81288.1 - 3.7e-47 160.9 0.0 3.7e-47 160.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Haspin_kinase PF12330.8 EFA81288.1 - 0.029 13.3 0.2 0.029 13.3 0.2 3.2 3 0 0 3 3 3 0 Haspin like kinase domain AAA_23 PF13476.6 EFA81288.1 - 6.8 7.1 19.8 0.096 13.2 9.5 2.6 2 1 0 2 2 2 0 AAA domain Prenyltransf PF01255.19 EFA81289.1 - 1.6e-07 31.1 1.0 2e-07 30.8 1.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Spc7_N PF15402.6 EFA81289.1 - 0.002 16.5 0.1 0.0026 16.1 0.1 1.1 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 TIP49 PF06068.13 EFA81290.1 - 2.7e-153 510.3 5.9 2.7e-153 510.3 5.9 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 EFA81290.1 - 3e-27 94.5 1.2 1.2e-26 92.6 1.2 2.2 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EFA81290.1 - 5.4e-09 36.6 2.1 3.4e-05 24.3 0.2 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFA81290.1 - 6.8e-08 32.4 0.9 0.0013 18.5 0.1 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 EFA81290.1 - 1.3e-05 24.6 0.3 2.7e-05 23.6 0.3 1.5 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_19 PF13245.6 EFA81290.1 - 2.1e-05 24.9 1.1 0.00014 22.2 1.1 2.1 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFA81290.1 - 2.7e-05 23.9 0.2 0.027 14.2 0.1 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EFA81290.1 - 4.6e-05 23.7 0.1 0.1 12.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFA81290.1 - 5.4e-05 23.2 0.9 0.022 14.7 0.2 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA81290.1 - 0.00016 22.1 0.6 0.00059 20.2 0.6 2.0 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EFA81290.1 - 0.00062 19.2 1.1 0.037 13.4 0.4 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EFA81290.1 - 0.012 15.2 0.1 0.026 14.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFA81290.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 EFA81290.1 - 0.014 14.7 2.3 0.029 13.7 2.3 1.5 1 1 0 1 1 1 0 KaiC DUF2075 PF09848.9 EFA81290.1 - 0.021 14.1 0.0 0.043 13.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 EFA81290.1 - 0.022 14.0 1.5 1.2 8.3 0.4 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_7 PF12775.7 EFA81290.1 - 0.026 14.0 0.5 0.083 12.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EFA81290.1 - 0.028 13.7 0.2 0.059 12.6 0.2 1.5 1 0 0 1 1 1 0 Zeta toxin ResIII PF04851.15 EFA81290.1 - 0.056 13.4 1.2 2.9 7.9 1.2 2.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFA81290.1 - 0.075 12.7 2.4 0.91 9.2 0.7 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFA81290.1 - 0.075 13.3 0.8 0.48 10.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EFA81290.1 - 0.091 12.5 0.4 0.18 11.6 0.4 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFA81290.1 - 0.095 13.2 0.8 0.19 12.2 0.8 1.5 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EFA81290.1 - 0.096 13.1 2.7 0.59 10.6 0.9 2.9 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EFA81290.1 - 0.098 12.7 0.1 0.31 11.0 0.1 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RdRP PF05183.12 EFA81291.1 - 5.1e-124 415.1 0.0 1e-123 414.1 0.0 1.5 1 0 0 1 1 1 1 RNA dependent RNA polymerase ResIII PF04851.15 EFA81291.1 - 5.7e-18 65.5 0.5 5.7e-18 65.5 0.5 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFA81291.1 - 9e-18 64.6 0.4 2.3e-17 63.3 0.4 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81291.1 - 1.2e-16 61.1 3.0 1.6e-16 60.7 0.4 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFA81291.1 - 0.00091 18.0 1.4 0.0021 16.9 1.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain TIG PF01833.24 EFA81293.1 - 5.1e-08 32.9 25.7 0.00014 21.9 0.1 6.2 3 2 2 5 5 5 4 IPT/TIG domain Pkinase_Tyr PF07714.17 EFA81294.1 - 4.5e-60 203.1 0.1 1e-59 202.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA81294.1 - 1.1e-47 162.6 0.0 2.2e-47 161.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 EFA81294.1 - 5.9e-41 140.4 0.3 1.6e-40 139.0 0.0 1.9 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain Roc PF08477.13 EFA81294.1 - 1.6e-06 28.4 0.0 4.5e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase HAP2-GCS1 PF10699.9 EFA81296.1 - 0.0017 18.3 0.2 0.0051 16.8 0.2 1.8 1 0 0 1 1 1 1 Male gamete fusion factor BRCT_3 PF18428.1 EFA81297.1 - 1.1e-15 57.6 0.1 1.5e-14 53.9 0.0 2.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 EFA81297.1 - 1.8e-10 41.0 6.8 2.7e-06 27.7 0.1 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA81297.1 - 0.00024 21.4 8.2 0.0011 19.3 0.1 3.8 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain 7tm_1 PF00001.21 EFA81298.1 - 2.2e-12 46.9 7.8 2.3e-12 46.8 7.3 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_2 PF00002.24 EFA81298.1 - 6.8e-09 35.4 12.1 9.3e-09 34.9 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Ocular_alb PF02101.15 EFA81298.1 - 0.00034 19.7 16.6 0.013 14.4 16.4 2.9 1 1 0 1 1 1 1 Ocular albinism type 1 protein GPR_Gpa2_C PF11970.8 EFA81298.1 - 0.0023 18.0 0.4 0.0023 18.0 0.4 2.4 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Macoilin PF09726.9 EFA81299.1 - 0.033 12.7 12.1 0.035 12.7 12.1 1.2 1 0 0 1 1 1 0 Macoilin family Suf PF05843.14 EFA81299.1 - 0.08 12.9 8.4 0.15 12.0 8.4 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CDK2AP PF09806.9 EFA81299.1 - 0.14 12.2 11.4 0.31 11.1 11.4 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein SUIM_assoc PF16619.5 EFA81299.1 - 0.72 10.0 21.3 3 8.0 8.4 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Roughex PF06020.11 EFA81299.1 - 0.8 8.7 8.8 0.72 8.9 3.7 2.2 2 0 0 2 2 2 0 Drosophila roughex protein ASD2 PF08687.11 EFA81299.1 - 1.3 8.5 9.7 2.8 7.4 2.3 2.9 3 0 0 3 3 3 0 Apx/Shroom domain ASD2 RabGAP-TBC PF00566.18 EFA81300.1 - 4.4e-56 189.9 4.0 4.4e-56 189.9 4.0 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Ank_5 PF13857.6 EFA81300.1 - 1.5e-08 34.7 0.0 3.6e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81300.1 - 4.3e-07 30.4 0.0 9.5e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFA81300.1 - 1.9e-06 28.1 0.0 4.5e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 EFA81300.1 - 2e-06 28.2 0.0 5.2e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81300.1 - 0.00011 22.3 0.0 0.00028 21.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat PAP1 PF08601.10 EFA81300.1 - 1.1 8.9 33.7 1.9 8.1 33.7 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Macoilin PF09726.9 EFA81300.1 - 1.1 7.7 24.0 1.8 7.0 24.0 1.4 1 0 0 1 1 1 0 Macoilin family Ependymin PF00811.18 EFA81301.1 - 1.2e-08 35.2 0.6 3.2e-08 33.9 0.6 1.8 1 1 0 1 1 1 1 Ependymin Fz PF01392.22 EFA81301.1 - 0.00081 20.0 10.2 0.0017 19.0 10.2 1.6 1 0 0 1 1 1 1 Fz domain Kelch_4 PF13418.6 EFA81302.1 - 1.1e-36 124.5 24.4 1.9e-10 40.6 0.1 6.7 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA81302.1 - 7.9e-29 99.2 9.5 1e-07 31.8 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFA81302.1 - 1.6e-26 91.7 15.1 8.7e-07 29.0 0.1 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFA81302.1 - 3.9e-24 84.4 24.6 8e-09 35.6 0.1 6.4 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA81302.1 - 1.8e-18 65.9 8.6 3.1e-07 29.8 0.2 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFA81302.1 - 6.9e-14 51.2 5.7 0.0028 17.6 0.1 6.5 7 0 0 7 7 7 3 Kelch motif DUF287 PF03384.14 EFA81302.1 - 0.021 15.2 0.6 3.2 8.2 0.0 3.4 4 0 0 4 4 4 0 Drosophila protein of unknown function, DUF287 7TM_GPCR_Srd PF10317.9 EFA81302.1 - 0.029 13.6 0.0 0.052 12.7 0.0 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd LapA_dom PF06305.11 EFA81302.1 - 0.3 10.9 1.1 35 4.3 0.8 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Syja_N PF02383.18 EFA81303.1 - 2.2e-81 273.7 0.2 2.2e-81 273.7 0.2 2.5 3 1 1 4 4 4 1 SacI homology domain WYL PF13280.6 EFA81303.1 - 0.0076 16.3 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 WYL domain RabGAP-TBC PF00566.18 EFA81304.1 - 1.3e-42 145.9 2.5 1.3e-42 145.9 2.5 2.9 3 0 0 3 3 3 1 Rab-GTPase-TBC domain HlyD_2 PF12700.7 EFA81304.1 - 0.82 8.3 11.8 1.9 7.2 11.8 1.5 1 0 0 1 1 1 0 HlyD family secretion protein BTB_2 PF02214.22 EFA81305.1 - 1.4e-13 51.0 0.0 3.1e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Rhodanese PF00581.20 EFA81306.1 - 0.00017 22.1 0.0 0.00037 21.0 0.0 1.6 1 1 0 1 1 1 1 Rhodanese-like domain Collectrin PF16959.5 EFA81306.1 - 0.011 15.5 0.5 0.016 15.0 0.5 1.3 1 0 0 1 1 1 0 Renal amino acid transporter Ank_2 PF12796.7 EFA81307.1 - 0.00039 20.9 0.7 0.038 14.6 0.0 3.5 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) ChAPs PF09295.10 EFA81308.1 - 8.4e-43 146.9 1.2 2e-41 142.3 1.1 2.6 2 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_8 PF13181.6 EFA81308.1 - 9.3e-06 25.5 0.0 0.11 12.8 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81308.1 - 1.3e-05 25.6 0.0 0.063 14.1 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81308.1 - 1.4e-05 24.8 0.0 0.41 10.9 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA81308.1 - 3.7e-05 24.1 0.0 0.0067 16.9 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA81308.1 - 5.9e-05 22.7 0.0 0.073 12.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFA81308.1 - 0.00069 18.9 0.1 0.0049 16.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA81308.1 - 0.0025 17.7 0.0 5.8 7.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81308.1 - 0.0089 16.3 0.5 0.86 9.9 0.0 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81308.1 - 0.0096 15.6 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.6 EFA81308.1 - 0.022 15.4 0.0 0.93 10.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA81308.1 - 0.033 14.4 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2205 PF10224.9 EFA81308.1 - 0.045 13.7 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Short coiled-coil protein Dicty_REP PF05086.12 EFA81308.1 - 0.053 11.5 8.6 0.078 11.0 8.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tim29 PF10171.9 EFA81308.1 - 0.083 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Translocase of the Inner Mitochondrial membrane 29 TPR_6 PF13174.6 EFA81308.1 - 0.085 13.5 0.0 2.9 8.7 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA81308.1 - 0.11 12.5 0.2 58 3.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4919 PF16266.5 EFA81308.1 - 0.15 12.0 0.2 0.36 10.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) BAP PF06639.11 EFA81308.1 - 0.39 11.1 2.9 0.87 10.0 0.1 2.3 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) Med13_C PF06333.12 EFA81308.1 - 1.5 8.0 12.3 3 7.0 8.6 2.2 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain E1-E2_ATPase PF00122.20 EFA81309.1 - 9.5e-47 158.9 3.1 9.5e-47 158.9 3.1 1.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFA81309.1 - 7.8e-40 136.5 2.7 7.8e-40 136.5 2.7 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFA81309.1 - 4e-23 82.8 0.0 5.4e-12 46.4 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA81309.1 - 1.9e-22 79.2 0.0 4e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFA81309.1 - 2.8e-15 55.8 0.0 6.7e-15 54.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA81309.1 - 0.0015 18.3 0.3 0.0015 18.3 0.3 3.3 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA81309.1 - 0.0066 16.9 0.0 0.023 15.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3040 PF11239.8 EFA81309.1 - 0.88 9.9 6.3 0.21 11.9 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) GLE1 PF07817.13 EFA81310.1 - 3.1e-55 187.1 2.6 8.8e-55 185.6 2.6 1.8 1 0 0 1 1 1 1 GLE1-like protein DUF948 PF06103.11 EFA81310.1 - 0.64 10.3 8.4 5.6 7.3 0.1 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Mito_carr PF00153.27 EFA81311.1 - 4.5e-62 206.0 0.9 2e-19 69.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SWIM PF04434.17 EFA81312.1 - 0.0078 15.9 0.3 0.018 14.7 0.3 1.6 1 0 0 1 1 1 1 SWIM zinc finger SDA1 PF05285.12 EFA81312.1 - 0.021 14.2 34.3 0.024 14.1 34.3 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFA81312.1 - 0.057 11.6 33.2 0.061 11.5 33.2 1.0 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.12 EFA81312.1 - 0.13 10.6 31.4 0.15 10.4 31.4 1.0 1 0 0 1 1 1 0 Mpp10 protein BUD22 PF09073.10 EFA81312.1 - 1.8 7.9 33.4 2 7.6 33.4 1.1 1 0 0 1 1 1 0 BUD22 TFIIA PF03153.13 EFA81312.1 - 2.2 8.2 29.9 2.7 7.9 29.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF913 PF06025.12 EFA81312.1 - 2.3 7.1 8.9 3.1 6.7 8.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2076 PF09849.9 EFA81312.1 - 5.9 6.9 13.1 8.6 6.3 13.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RP-C_C PF11800.8 EFA81312.1 - 6.7 6.7 7.2 8.5 6.4 7.2 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 EFA81312.1 - 7.6 5.2 10.2 8.5 5.0 10.2 1.1 1 0 0 1 1 1 0 Presenilin Aa_trans PF01490.18 EFA81313.1 - 6.1e-35 120.7 28.1 2.5e-32 112.1 23.6 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein DDDD PF10161.9 EFA81313.1 - 0.17 11.7 0.3 1.7 8.4 0.1 2.4 2 0 0 2 2 2 0 Putative mitochondrial precursor protein Rap_GAP PF02145.15 EFA81315.1 - 2.2e-60 203.4 2.6 3.1e-60 202.9 0.8 2.2 2 0 0 2 2 2 1 Rap/ran-GAP Maf1 PF09174.10 EFA81316.1 - 1.6e-27 96.8 0.7 1.6e-27 96.8 0.7 2.7 2 1 0 2 2 2 1 Maf1 regulator SPRY PF00622.28 EFA81316.1 - 3.4e-15 56.2 0.2 9.5e-15 54.8 0.2 1.8 1 0 0 1 1 1 1 SPRY domain F-box-like PF12937.7 EFA81316.1 - 2.5e-05 24.1 0.0 5e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EFA81316.1 - 0.00098 19.4 0.2 0.00098 19.4 0.2 3.6 3 0 0 3 3 3 1 PRANC domain F-box_4 PF15966.5 EFA81316.1 - 0.0031 17.4 0.0 0.0069 16.3 0.0 1.5 1 0 0 1 1 1 1 F-box Neuralized PF07177.12 EFA81316.1 - 0.0069 16.4 0.1 0.031 14.3 0.0 2.1 2 1 0 2 2 2 1 Neuralized F-box PF00646.33 EFA81316.1 - 0.036 14.0 0.1 0.084 12.8 0.1 1.6 1 0 0 1 1 1 0 F-box domain DUF1474 PF07342.11 EFA81316.1 - 0.2 12.2 5.0 0.13 12.8 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) Steroid_dh PF02544.16 EFA81317.1 - 2.2e-20 73.2 4.3 2.2e-20 73.2 4.3 3.1 1 1 2 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF2615 PF11027.8 EFA81317.1 - 0.35 11.0 6.5 6 7.1 0.1 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2615) DUF2850 PF11012.8 EFA81319.1 - 0.27 11.5 5.6 0.41 11.0 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2850) GSP_synth PF03738.14 EFA81320.1 - 1.2e-07 31.2 0.0 1.9e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp Peptidase_M3 PF01432.20 EFA81321.1 - 6.2e-09 35.6 0.1 6.2e-09 35.6 0.1 2.1 3 1 0 3 3 3 1 Peptidase family M3 DUF4473 PF14747.6 EFA81321.1 - 0.11 13.1 0.7 0.29 11.7 0.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) FAM184 PF15665.5 EFA81321.1 - 1.6 8.5 11.5 0.76 9.5 7.1 2.5 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B MRP-S28 PF10213.9 EFA81323.1 - 1.7e-11 44.6 1.6 1.7e-11 44.6 1.6 3.4 3 0 0 3 3 3 1 Mitochondrial ribosomal subunit protein DUF4834 PF16118.5 EFA81323.1 - 1.4 9.9 10.6 0.51 11.3 3.4 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Methyltransf_2 PF00891.18 EFA81324.1 - 1.7e-36 125.5 0.0 3.2e-36 124.6 0.0 1.4 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EFA81324.1 - 0.0028 17.5 0.0 0.0049 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Rrf2 PF02082.20 EFA81324.1 - 0.024 15.0 0.0 0.052 13.9 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Aminotran_1_2 PF00155.21 EFA81325.1 - 3.2e-34 118.7 0.0 5.6e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Methyltransf_2 PF00891.18 EFA81326.1 - 6.8e-34 117.0 0.0 8.8e-34 116.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EFA81326.1 - 0.0019 18.1 0.0 0.0046 16.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 EFA81327.1 - 1.1e-61 207.9 0.0 3.9e-31 108.0 0.0 2.3 2 0 0 2 2 2 2 O-methyltransferase domain Rrf2 PF02082.20 EFA81327.1 - 4.7e-05 23.7 0.0 0.48 10.8 0.0 2.7 2 0 0 2 2 2 2 Transcriptional regulator Methyltransf_12 PF08242.12 EFA81327.1 - 0.0097 16.6 0.3 8.6 7.2 0.0 4.1 4 1 0 4 4 4 1 Methyltransferase domain HTH_11 PF08279.12 EFA81327.1 - 0.015 15.3 0.0 0.065 13.2 0.0 2.0 2 0 0 2 2 2 0 HTH domain Arg_decarb_HB PF17810.1 EFA81327.1 - 0.043 14.1 0.5 5.1 7.4 0.0 2.6 2 0 0 2 2 2 0 Arginine decarboxylase helical bundle domain Mito_carr PF00153.27 EFA81328.1 - 1.1e-47 159.9 1.1 7.5e-20 70.7 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein FNIP PF05725.12 EFA81328.1 - 1.1e-36 124.7 9.7 7.5e-12 45.2 0.0 7.8 5 2 1 6 6 6 5 FNIP Repeat F-box_5 PF18511.1 EFA81328.1 - 0.00024 20.6 0.1 0.0007 19.1 0.1 1.8 1 0 0 1 1 1 1 F-box Sec23_trunk PF04811.15 EFA81329.1 - 9.2e-66 221.9 0.0 1.5e-65 221.1 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EFA81329.1 - 8.2e-25 86.6 0.7 2.3e-24 85.2 0.7 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EFA81329.1 - 9.2e-18 64.8 0.2 2.1e-17 63.6 0.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFA81329.1 - 7.4e-17 61.1 2.5 1.5e-16 60.2 2.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFA81329.1 - 7.7e-06 25.7 0.0 7.7e-06 25.7 0.0 2.5 2 0 0 2 2 2 1 Gelsolin repeat DUF3899 PF13038.6 EFA81330.1 - 0.017 15.6 0.0 0.032 14.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Cadherin_C_2 PF16492.5 EFA81330.1 - 0.13 13.1 0.8 0.41 11.4 0.1 2.1 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal AflR PF08493.10 EFA81330.1 - 5.1 6.5 9.8 7.9 5.9 9.8 1.2 1 0 0 1 1 1 0 Aflatoxin regulatory protein FixS PF03597.15 EFA81330.1 - 5.3 6.8 6.6 11 5.8 6.6 1.5 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Ank_2 PF12796.7 EFA81331.1 - 4.2e-36 123.4 16.8 5.3e-10 39.8 0.9 6.9 3 1 3 7 7 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81331.1 - 4e-25 87.9 16.4 0.0001 22.8 0.0 10.6 7 3 3 11 11 10 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81331.1 - 2.8e-22 78.5 18.0 0.069 13.5 0.2 12.5 3 2 11 14 14 14 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81331.1 - 3.8e-19 66.8 10.7 2.1 9.2 0.1 13.6 11 2 3 14 14 14 3 Ankyrin repeat Ank PF00023.30 EFA81331.1 - 0.0002 21.7 8.6 88 3.8 0.2 9.3 8 3 1 9 9 8 0 Ankyrin repeat DUF5049 PF16468.5 EFA81331.1 - 0.002 18.0 0.4 23 5.0 0.0 5.5 7 1 1 8 8 8 0 Domain of unknown function (DUF5049) Presenilin PF01080.17 EFA81331.1 - 0.2 10.4 6.4 0.34 9.6 6.4 1.3 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 EFA81331.1 - 0.36 10.8 19.7 0.56 10.1 19.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spore_YhcN_YlaJ PF09580.10 EFA81331.1 - 1.1 9.3 16.0 2.2 8.4 16.0 1.5 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EPL1 PF10513.9 EFA81331.1 - 1.2 9.5 15.0 0.7 10.3 1.4 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like SMYLE_N PF18615.1 EFA81331.1 - 2.3 7.7 11.2 4.1 6.9 11.2 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain AIF_C PF14721.6 EFA81331.1 - 4.6 7.6 8.2 3.5 8.0 0.6 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term zf-C2H2_9 PF16293.5 EFA81332.1 - 3.2 7.7 6.7 0.48 10.3 0.9 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Lyase_8 PF02278.18 EFA81334.1 - 1.6e-68 231.0 4.0 1.6e-68 231.0 4.0 2.0 2 0 0 2 2 2 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_C PF02884.17 EFA81334.1 - 2.1e-21 76.2 0.8 6.3e-21 74.6 0.8 1.9 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain DJ-1_PfpI PF01965.24 EFA81335.1 - 2.6e-48 163.9 0.0 3e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EFA81335.1 - 0.0021 17.8 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ThiJ_like PF17124.5 EFA81335.1 - 0.0046 16.7 0.1 0.056 13.1 0.0 2.2 1 1 1 2 2 2 1 ThiJ/PfpI family-like SNO PF01174.19 EFA81335.1 - 0.076 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family GATase_3 PF07685.14 EFA81335.1 - 0.096 12.3 0.0 0.22 11.1 0.0 1.5 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain NETI PF14044.6 EFA81336.1 - 0.078 12.7 0.3 0.63 9.8 0.1 2.1 2 0 0 2 2 2 0 NETI protein DEAD PF00270.29 EFA81338.1 - 8.1e-52 175.5 0.1 4.4e-51 173.1 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81338.1 - 1.1e-28 99.8 0.0 1e-27 96.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RRM_1 PF00076.22 EFA81339.1 - 2.4e-21 75.3 0.0 4.7e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bromodomain PF00439.25 EFA81339.1 - 5.8e-18 64.8 0.2 3.2e-17 62.4 0.2 2.4 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EFA81339.1 - 3.4e-05 23.8 0.0 0.0001 22.3 0.0 1.8 1 0 0 1 1 1 1 Bromodomain associated LRR_6 PF13516.6 EFA81340.1 - 2.7e-07 30.1 30.1 0.96 9.7 1.2 8.8 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 EFA81340.1 - 1.5e-05 25.3 35.5 0.0003 21.1 3.7 7.9 5 1 4 9 9 9 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA81340.1 - 0.016 15.7 25.7 10 7.1 0.4 9.8 9 0 0 9 9 9 0 Leucine Rich Repeat POTRA_1 PF08478.10 EFA81340.1 - 0.026 14.8 0.0 0.13 12.6 0.0 2.2 2 0 0 2 2 2 0 POTRA domain, FtsQ-type DUF357 PF04010.13 EFA81340.1 - 0.04 14.0 0.2 0.17 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF357) LRR_2 PF07723.13 EFA81340.1 - 0.31 11.8 0.1 0.31 11.8 0.1 5.7 6 0 0 6 6 6 0 Leucine Rich Repeat USP7_C2 PF14533.6 EFA81341.1 - 0.0092 15.7 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal InPase PF18823.1 EFA81341.1 - 0.1 12.3 0.1 0.71 9.6 0.0 1.9 1 1 1 2 2 2 0 Inorganic Pyrophosphatase Ureide_permease PF07168.11 EFA81342.1 - 0.95 8.1 3.4 1.5 7.5 3.4 1.3 1 0 0 1 1 1 0 Ureide permease CENP-H PF05837.12 EFA81343.1 - 0.031 14.7 2.2 0.031 14.7 2.2 3.5 3 1 0 3 3 3 0 Centromere protein H (CENP-H) zf-RING_5 PF14634.6 EFA81343.1 - 0.063 13.3 6.7 0.12 12.4 6.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain C1_4 PF07975.12 EFA81343.1 - 0.091 13.0 5.1 0.35 11.1 5.1 2.1 1 0 0 1 1 1 0 TFIIH C1-like domain zf-HIT PF04438.16 EFA81343.1 - 6.1 6.8 9.4 3.1 7.8 3.6 2.2 2 0 0 2 2 2 0 HIT zinc finger TFIIS_C PF01096.18 EFA81344.1 - 1.4e-10 40.9 9.4 4.8e-10 39.1 1.6 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EFA81344.1 - 5.5e-09 35.8 3.0 5.5e-09 35.8 3.0 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Nudix_N_2 PF14803.6 EFA81344.1 - 0.00032 20.6 0.2 0.00032 20.6 0.2 3.1 3 0 0 3 3 3 1 Nudix N-terminal zf-RING_5 PF14634.6 EFA81344.1 - 0.0052 16.7 6.7 0.39 10.7 1.0 3.1 3 0 0 3 3 3 1 zinc-RING finger domain DpnI PF06044.12 EFA81344.1 - 0.028 14.0 1.7 0.1 12.2 0.1 2.0 2 0 0 2 2 2 0 Dam-replacing family IBR PF01485.21 EFA81344.1 - 0.063 13.5 8.5 0.11 12.7 1.0 2.9 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Terminase_GpA PF05876.12 EFA81344.1 - 0.08 11.5 4.1 0.035 12.7 1.4 1.6 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) zinc-ribbons_6 PF07191.12 EFA81344.1 - 0.094 12.7 8.0 0.83 9.7 0.2 2.9 2 1 0 2 2 2 0 zinc-ribbons zf-RRPl_C4 PF17026.5 EFA81344.1 - 0.13 12.4 4.3 0.38 10.9 4.3 1.9 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zinc_ribbon_4 PF13717.6 EFA81344.1 - 0.17 11.8 10.1 4.8 7.2 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon domain zf-Mss51 PF13824.6 EFA81344.1 - 0.19 11.8 6.2 0.59 10.3 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Auto_anti-p27 PF06677.12 EFA81344.1 - 0.22 11.7 13.4 0.2 11.8 2.0 3.0 3 1 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn_Tnp_IS1595 PF12760.7 EFA81344.1 - 0.25 11.4 11.7 0.22 11.5 1.2 3.0 2 2 0 2 2 2 0 Transposase zinc-ribbon domain zf-C3HC4_3 PF13920.6 EFA81344.1 - 0.25 11.2 6.9 8.1 6.4 0.9 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_10 PF10058.9 EFA81344.1 - 0.41 10.4 9.6 1.9 8.3 1.0 3.1 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein HypA PF01155.19 EFA81344.1 - 0.43 10.6 4.8 2.1 8.4 3.2 2.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 EFA81344.1 - 0.53 10.6 7.6 17 5.8 2.0 3.3 3 1 0 3 3 3 0 zinc-ribbon zf-C3HC4_4 PF15227.6 EFA81344.1 - 1.1 9.5 9.4 1.4 9.1 1.0 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Cys_rich_KTR PF14205.6 EFA81344.1 - 1.1 9.2 14.7 1.3 8.9 0.2 3.6 3 1 1 4 4 4 0 Cysteine-rich KTR zf-ribbon_3 PF13248.6 EFA81344.1 - 1.6 8.2 15.5 2.1 7.8 0.0 4.1 4 0 0 4 4 4 0 zinc-ribbon domain DUF2387 PF09526.10 EFA81344.1 - 2.9 8.1 7.2 3.9 7.7 0.7 2.3 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) DZR PF12773.7 EFA81344.1 - 3.1 7.9 11.1 8.8 6.4 1.4 2.8 2 2 0 2 2 2 0 Double zinc ribbon RNHCP PF12647.7 EFA81344.1 - 3.5 7.6 7.9 4.9 7.2 0.1 2.9 2 1 1 3 3 3 0 RNHCP domain PKHD_C PF18331.1 EFA81345.1 - 0.01 15.9 0.3 0.041 13.9 0.4 2.0 2 0 0 2 2 2 0 PKHD-type hydroxylase C-terminal domain DUF1664 PF07889.12 EFA81345.1 - 0.041 13.9 0.2 0.071 13.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3014 PF11219.8 EFA81346.1 - 0.075 13.3 0.2 0.16 12.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3014) LemA PF04011.12 EFA81346.1 - 0.14 12.0 1.0 0.82 9.5 0.4 2.3 1 1 1 2 2 2 0 LemA family EB PF01683.18 EFA81347.1 - 0.00024 21.3 4.7 0.00064 20.0 4.7 1.7 1 0 0 1 1 1 1 EB module I-EGF_1 PF18372.1 EFA81347.1 - 0.006 16.6 8.3 0.014 15.4 8.3 1.6 1 0 0 1 1 1 1 Integrin beta epidermal growth factor like domain 1 DUF3481 PF11980.8 EFA81347.1 - 0.012 15.3 0.1 0.032 13.9 0.1 1.6 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein EGF_2 PF07974.13 EFA81347.1 - 0.026 14.9 17.8 0.069 13.5 17.8 1.7 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 EFA81348.1 - 2.5e-08 34.1 12.5 0.00087 19.5 2.8 2.6 2 0 0 2 2 2 2 EB module EGF_2 PF07974.13 EFA81348.1 - 0.0012 19.1 49.8 0.04 14.3 20.2 2.6 2 0 0 2 2 2 2 EGF-like domain I-EGF_1 PF18372.1 EFA81348.1 - 0.0048 17.0 30.7 0.14 12.3 10.3 2.8 2 0 0 2 2 2 2 Integrin beta epidermal growth factor like domain 1 UPF0669 PF17065.5 EFA81348.1 - 0.0073 16.1 0.0 5 6.8 0.0 2.5 2 0 0 2 2 2 2 Putative cytokine, C6ORF120 PI_PP_C PF18365.1 EFA81348.1 - 0.011 15.7 0.8 6 6.9 0.1 2.5 2 0 0 2 2 2 0 Phosphoinositide phosphatase C-terminal domain Peptidase_S9 PF00326.21 EFA81351.1 - 6.9e-06 25.7 0.0 1.4e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFA81351.1 - 0.0017 17.7 0.0 0.71 9.1 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EFA81351.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Esterase_phd PF10503.9 EFA81351.1 - 0.12 11.9 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase AMP-binding PF00501.28 EFA81353.1 - 3.8e-62 210.2 0.0 6.3e-62 209.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFA81353.1 - 3.4e-55 187.0 0.0 5.9e-55 186.2 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFA81353.1 - 6.3e-09 35.6 0.1 1.4e-08 34.5 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA81353.1 - 4.4e-08 32.5 0.1 1.8e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EFA81353.1 - 2.1e-07 31.2 1.8 5.8e-07 29.8 0.1 2.6 3 0 0 3 3 3 1 Phosphopantetheine attachment site ZZ PF00569.17 EFA81353.1 - 2.1e-06 27.4 2.7 4.4e-06 26.4 2.7 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type GDP_Man_Dehyd PF16363.5 EFA81353.1 - 3.3e-05 23.5 2.5 5.4e-05 22.7 0.2 2.6 3 1 0 3 3 3 1 GDP-mannose 4,6 dehydratase Sporozoite_P67 PF05642.11 EFA81353.1 - 0.0014 16.9 0.9 0.0019 16.4 0.9 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen Mucin PF01456.17 EFA81353.1 - 0.0046 17.0 9.1 0.0079 16.2 9.1 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein zf-C4pol PF14260.6 EFA81353.1 - 0.17 12.4 4.1 0.56 10.7 4.1 1.9 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta HNF-1_N PF04814.13 EFA81353.1 - 1.6 9.3 10.6 1.6 9.3 8.6 2.1 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF3439 PF11921.8 EFA81353.1 - 2 8.4 8.8 6.3 6.8 8.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pap_E4 PF02711.14 EFA81353.1 - 3.1 8.8 9.8 9.6 7.2 9.8 1.8 1 0 0 1 1 1 0 E4 protein MGC-24 PF05283.11 EFA81353.1 - 3.5 8.1 15.4 8 6.9 15.4 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin EGF_2 PF07974.13 EFA81354.1 - 0.001 19.4 15.6 0.0022 18.3 15.6 1.6 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA81354.1 - 0.0025 18.1 4.4 0.0073 16.6 4.4 1.8 1 0 0 1 1 1 1 EB module Hpr_kinase_C PF07475.12 EFA81354.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Glutaredoxin2_C PF04399.13 EFA81354.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain hEGF PF12661.7 EFA81354.1 - 0.59 10.9 7.4 1.6 9.5 7.4 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF TIG PF01833.24 EFA81354.1 - 0.61 10.2 21.0 0.17 12.0 0.2 5.1 5 1 0 5 5 5 0 IPT/TIG domain EGF_Tenascin PF18720.1 EFA81354.1 - 4.7 7.4 10.7 16 5.7 10.7 2.0 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 EFA81355.1 - 0.00087 19.6 15.2 0.0022 18.3 15.2 1.7 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA81355.1 - 0.0018 18.5 5.1 0.0042 17.3 5.1 1.6 1 0 0 1 1 1 1 EB module EGF PF00008.27 EFA81355.1 - 0.17 12.3 7.4 0.35 11.2 7.4 1.6 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA81355.1 - 0.22 12.2 6.3 0.58 10.9 6.3 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFA81355.1 - 3.7 7.7 12.5 8.4 6.6 12.5 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EB PF01683.18 EFA81356.1 - 8.8e-07 29.1 12.5 0.00083 19.6 3.7 2.6 2 0 0 2 2 2 2 EB module EGF_2 PF07974.13 EFA81356.1 - 0.04 14.3 35.8 0.26 11.7 20.2 2.6 2 0 0 2 2 2 0 EGF-like domain UPF0669 PF17065.5 EFA81356.1 - 0.1 12.3 0.0 5.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Putative cytokine, C6ORF120 Epiglycanin_C PF14654.6 EFA81356.1 - 0.39 10.8 3.4 14 5.8 0.1 3.1 3 0 0 3 3 3 0 Mucin, catalytic, TM and cytoplasmic tail region I-EGF_1 PF18372.1 EFA81356.1 - 5.2 7.3 26.3 0.42 10.7 11.8 2.5 2 0 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 FKBP_C PF00254.28 EFA81357.1 - 1e-33 115.5 0.0 1.4e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Alg14 PF08660.11 EFA81358.1 - 4.1e-32 111.5 0.0 7.2e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_tran_28_C PF04101.16 EFA81358.1 - 5.2e-20 72.1 0.0 9.6e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain FMO-like PF00743.19 EFA81358.1 - 0.086 11.2 0.0 0.19 10.1 0.0 1.6 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Got1 PF04178.12 EFA81359.1 - 3.2e-29 101.6 17.4 6.6e-29 100.6 17.1 1.6 1 1 1 2 2 2 2 Got1/Sft2-like family Sdh_cyt PF01127.22 EFA81359.1 - 0.081 13.0 5.5 0.07 13.2 3.1 2.1 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF5305 PF17231.2 EFA81359.1 - 0.25 10.7 1.3 0.55 9.6 0.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5305) FA_desaturase PF00487.24 EFA81359.1 - 0.32 10.8 2.5 0.47 10.2 2.5 1.3 1 0 0 1 1 1 0 Fatty acid desaturase TssN PF17555.2 EFA81359.1 - 5.2 6.4 14.0 7.2 5.9 14.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN zf-C3HC4_4 PF15227.6 EFA81360.1 - 0.016 15.3 4.6 0.016 15.3 4.6 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Cast PF10174.9 EFA81360.1 - 0.032 12.5 0.1 0.032 12.5 0.1 1.9 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone zf-C3HC4 PF00097.25 EFA81360.1 - 0.042 13.7 7.7 0.21 11.5 7.7 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PspB PF06667.12 EFA81360.1 - 0.044 13.8 0.2 0.044 13.8 0.2 2.0 2 0 0 2 2 2 0 Phage shock protein B PKcGMP_CC PF16808.5 EFA81360.1 - 0.067 13.1 0.5 0.13 12.2 0.5 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-RING_5 PF14634.6 EFA81360.1 - 0.24 11.4 10.0 0.89 9.6 10.0 2.1 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFA81360.1 - 0.29 11.2 7.7 0.82 9.8 7.7 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFA81360.1 - 0.52 10.6 6.7 2 8.7 6.7 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain Coilin_N PF15862.5 EFA81360.1 - 0.58 10.0 8.0 0.075 12.8 3.1 2.0 2 1 0 2 2 2 0 Coilin N-terminus zf-C3HC4_2 PF13923.6 EFA81360.1 - 0.58 10.1 8.7 1.8 8.5 8.7 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GST_C_3 PF14497.6 EFA81361.1 - 4.8e-19 68.4 0.2 8.1e-19 67.7 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA81361.1 - 2.6e-10 40.5 0.0 8.3e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA81361.1 - 8.1e-06 26.0 0.1 1.4e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA81361.1 - 0.00091 19.2 0.0 0.0031 17.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA81361.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA81361.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Med31 PF05669.12 EFA81362.1 - 0.0072 16.3 0.5 0.48 10.5 0.1 2.4 1 1 1 2 2 2 2 SOH1 F-box-like PF12937.7 EFA81363.1 - 0.024 14.5 0.1 0.074 13.0 0.1 1.8 1 0 0 1 1 1 0 F-box-like Methyltransf_16 PF10294.9 EFA81364.1 - 1.1e-21 77.4 0.0 1.8e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFA81364.1 - 3.3e-05 23.8 0.0 6.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA81364.1 - 0.00024 20.6 0.0 0.00037 20.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EFA81364.1 - 0.0028 18.3 0.0 0.0088 16.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA81364.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Met_10 PF02475.16 EFA81364.1 - 0.033 13.9 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Proteasom_PSMB PF10508.9 EFA81364.1 - 0.044 12.3 4.6 0.06 11.8 4.6 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Methyltransf_11 PF08241.12 EFA81364.1 - 0.085 13.5 0.0 0.27 11.9 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EFA81364.1 - 0.092 12.3 0.1 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 Nodulation protein S (NodS) Glyco_hydro_18 PF00704.28 EFA81365.1 - 2.4e-26 93.2 3.1 2.4e-26 93.2 3.1 1.8 2 1 0 2 2 2 1 Glycosyl hydrolases family 18 CBM49 PF09478.10 EFA81365.1 - 6.8e-13 48.7 1.6 5.1e-12 45.9 0.7 2.8 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 Pex2_Pex12 PF04757.14 EFA81366.1 - 1.2e-37 129.7 4.4 1.2e-37 129.7 4.4 2.0 2 1 0 2 2 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 EFA81366.1 - 7.3e-07 29.0 10.5 1.3e-06 28.1 10.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA81366.1 - 1.4e-06 28.1 7.0 2e-06 27.5 7.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA81366.1 - 5.3e-06 26.2 9.7 9.2e-06 25.4 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA81366.1 - 1.1e-05 25.3 7.6 1.7e-05 24.6 7.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFA81366.1 - 1.9e-05 24.6 8.1 3.7e-05 23.7 8.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFA81366.1 - 9.4e-05 22.7 9.6 0.00015 22.0 9.6 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFA81366.1 - 0.0051 16.6 10.7 0.043 13.7 11.0 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFA81366.1 - 0.012 15.7 12.7 0.025 14.8 12.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EFA81366.1 - 0.027 14.6 3.5 0.053 13.7 3.5 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EFA81366.1 - 0.041 14.2 4.3 0.096 13.0 4.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain dNK PF01712.19 EFA81367.1 - 3.1e-47 161.1 1.1 4.8e-47 160.4 0.2 1.8 1 1 1 2 2 2 1 Deoxynucleoside kinase AAA_18 PF13238.6 EFA81367.1 - 2.4e-09 37.8 0.1 8.5e-09 36.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain zf-Tim10_DDP PF02953.15 EFA81367.1 - 3.6e-09 36.1 4.0 3.6e-09 36.1 4.0 1.9 1 1 1 2 2 2 1 Tim10/DDP family zinc finger SAYSvFN PF10260.9 EFA81367.1 - 1.8e-08 34.2 1.6 4.4e-08 32.9 1.3 1.8 2 0 0 2 2 2 1 Uncharacterized conserved domain (SAYSvFN) Thymidylate_kin PF02223.17 EFA81367.1 - 0.0069 16.1 3.7 0.13 12.0 0.0 3.2 3 1 0 3 3 3 1 Thymidylate kinase AAA_33 PF13671.6 EFA81367.1 - 0.014 15.5 0.0 0.065 13.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFA81367.1 - 0.03 14.6 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFA81367.1 - 0.061 13.3 0.6 0.84 9.6 0.0 2.7 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Herpes_TK PF00693.18 EFA81367.1 - 0.16 11.2 0.9 0.27 10.4 0.1 1.7 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus AAA_17 PF13207.6 EFA81367.1 - 2.1 8.8 11.4 4 7.9 0.2 4.0 3 1 1 4 4 4 0 AAA domain Profilin PF00235.19 EFA81368.1 - 0.00035 20.9 0.1 0.0014 18.9 0.0 2.0 1 1 0 2 2 2 1 Profilin SCAI PF12070.8 EFA81369.1 - 2.7e-129 432.5 42.4 2.4e-67 228.0 10.3 3.4 2 1 1 3 3 3 2 Protein SCAI Dicty_CTDC PF00526.18 EFA81370.1 - 9.8e-47 156.4 182.3 1.2e-11 44.3 8.2 13.1 13 0 0 13 13 13 11 Dictyostelium (slime mold) repeat Ribosomal_S10 PF00338.22 EFA81372.1 - 5.3e-26 90.7 0.1 6.6e-26 90.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF2418 PF10332.9 EFA81373.1 - 4.1e-26 91.3 0.1 8.7e-26 90.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) Serglycin PF04360.12 EFA81373.1 - 0.68 9.9 21.4 0.12 12.3 5.3 3.5 3 1 0 3 3 3 0 Serglycin RRM_1 PF00076.22 EFA81374.1 - 3.3e-08 33.2 0.0 5e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EFA81374.1 - 4e-06 26.6 3.5 7.6e-06 25.8 3.5 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EFA81374.1 - 0.31 10.9 3.8 0.54 10.1 3.8 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EFA81374.1 - 1.3 8.8 9.8 0.18 11.6 3.3 2.1 2 0 0 2 2 2 0 Zinc knuckle AAA PF00004.29 EFA81375.1 - 3.7e-77 257.1 0.7 2.7e-43 147.6 0.0 3.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA81375.1 - 1.5e-30 104.7 1.0 5.5e-17 61.3 0.3 2.5 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EFA81375.1 - 8.1e-14 51.7 0.0 1.3e-06 28.2 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFA81375.1 - 2e-09 37.6 1.4 5.1e-05 23.3 0.0 3.9 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) CDC48_N PF02359.18 EFA81375.1 - 3.2e-09 36.8 0.0 9.2e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.6 EFA81375.1 - 8.1e-09 36.1 0.6 0.0035 17.7 0.0 3.5 2 2 0 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 EFA81375.1 - 1.3e-07 31.1 0.4 0.00022 20.6 0.0 3.0 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_22 PF13401.6 EFA81375.1 - 6.3e-07 29.8 0.4 0.045 14.0 0.1 4.1 2 2 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFA81375.1 - 7.5e-07 29.5 0.0 0.027 14.9 0.0 3.4 3 0 0 3 3 3 2 RNA helicase AAA_18 PF13238.6 EFA81375.1 - 3.6e-06 27.6 0.0 0.0025 18.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EFA81375.1 - 5e-06 26.7 0.0 0.0099 16.0 0.0 3.5 2 1 1 3 3 3 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EFA81375.1 - 6.4e-06 25.7 0.3 0.065 12.6 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFA81375.1 - 0.00011 22.4 0.0 0.32 11.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EFA81375.1 - 0.00015 21.5 0.0 0.66 9.7 0.0 3.0 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 EFA81375.1 - 0.00024 20.7 0.6 0.26 10.8 0.0 3.1 3 0 0 3 3 3 2 P-loop containing dynein motor region ATPase PF06745.13 EFA81375.1 - 0.00036 20.0 1.7 1.2 8.4 0.0 3.6 4 0 0 4 4 3 2 KaiC ABC_tran PF00005.27 EFA81375.1 - 0.00039 21.0 3.2 0.01 16.3 0.0 3.8 4 0 0 4 4 4 1 ABC transporter AAA_3 PF07726.11 EFA81375.1 - 0.00064 19.6 0.0 1.8 8.4 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFA81375.1 - 0.00091 19.3 2.4 0.0077 16.3 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.6 EFA81375.1 - 0.0013 18.4 0.1 3 7.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 EFA81375.1 - 0.0014 18.5 14.0 0.046 13.6 0.0 4.1 3 2 1 4 4 3 2 Rad17 P-loop domain AAA_24 PF13479.6 EFA81375.1 - 0.0015 18.3 0.1 0.11 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EFA81375.1 - 0.0026 17.8 0.0 1.4 9.0 0.0 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFA81375.1 - 0.0036 17.5 0.0 0.86 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EFA81375.1 - 0.0047 16.6 0.0 0.67 9.6 0.0 3.1 2 1 1 3 3 3 1 Sigma-54 interaction domain Vps4_C PF09336.10 EFA81375.1 - 0.0061 16.5 0.1 2.1 8.4 0.0 3.3 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain Sigma54_activ_2 PF14532.6 EFA81375.1 - 0.017 15.2 0.0 12 6.0 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_17 PF13207.6 EFA81375.1 - 0.029 14.8 0.3 9 6.7 0.0 3.5 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EFA81375.1 - 0.03 13.6 0.0 2.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin T2SSE PF00437.20 EFA81375.1 - 0.036 13.1 0.0 1.9 7.5 0.0 2.7 3 0 0 3 3 3 0 Type II/IV secretion system protein NACHT PF05729.12 EFA81375.1 - 0.052 13.5 0.7 3 7.7 0.1 3.6 2 1 0 2 2 2 0 NACHT domain RRM_DME PF15628.6 EFA81375.1 - 0.06 13.5 0.0 0.3 11.3 0.0 2.2 1 0 0 1 1 1 0 RRM in Demeter AAA_11 PF13086.6 EFA81375.1 - 0.26 11.0 5.1 2.9 7.6 0.1 3.3 2 1 1 3 3 3 0 AAA domain MIG-14_Wnt-bd PF06664.12 EFA81376.1 - 0.059 12.6 8.6 0.076 12.2 8.6 1.1 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Tmemb_18A PF09771.9 EFA81376.1 - 0.08 13.3 1.6 0.4 11.1 0.4 2.2 1 1 0 2 2 2 0 Transmembrane protein 188 Glyco_transf_10 PF00852.19 EFA81377.1 - 9.7e-35 119.9 0.6 2e-34 118.8 0.6 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Laminin_G_3 PF13385.6 EFA81377.1 - 4.6e-09 36.6 0.1 1.8e-08 34.7 0.1 1.9 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_tran_10_N PF17039.5 EFA81377.1 - 6.6e-07 29.8 0.0 1.8e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal FNIP PF05725.12 EFA81378.1 - 7.1e-21 74.1 10.6 1.6e-09 37.7 0.1 3.8 1 1 0 3 3 3 3 FNIP Repeat HIRA_B PF09453.10 EFA81378.1 - 0.05 13.5 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 HIRA B motif DASH_Dad4 PF08650.10 EFA81378.1 - 0.075 13.0 1.7 0.16 12.0 1.7 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad4 2OG-FeII_Oxy_2 PF13532.6 EFA81379.1 - 3.8e-20 72.9 0.0 6.1e-20 72.2 0.0 1.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Arf PF00025.21 EFA81380.1 - 1.8e-61 206.6 0.1 2e-61 206.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA81380.1 - 2e-15 57.0 0.1 2.9e-15 56.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFA81380.1 - 2.6e-13 49.9 2.4 1.8e-10 40.5 1.0 2.7 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFA81380.1 - 1.9e-12 47.1 0.1 2.1e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFA81380.1 - 6.8e-12 45.2 0.0 8.6e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFA81380.1 - 9e-09 35.0 0.0 1.1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA81380.1 - 3.4e-07 30.3 0.1 5.1e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EFA81380.1 - 0.00011 22.1 0.6 0.075 12.9 0.0 2.1 1 1 0 2 2 2 2 NACHT domain ABC_tran PF00005.27 EFA81380.1 - 0.0027 18.2 1.4 0.016 15.7 1.4 1.9 1 1 0 1 1 1 1 ABC transporter cobW PF02492.19 EFA81380.1 - 0.0092 15.6 0.4 3.7 7.1 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EFA81380.1 - 0.028 14.6 0.2 0.057 13.6 0.2 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFA81380.1 - 0.031 14.2 0.2 1.8 8.5 0.0 2.6 1 1 2 3 3 3 0 RsgA GTPase Mg_chelatase PF01078.21 EFA81380.1 - 0.053 12.9 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 EFA81380.1 - 0.065 12.9 0.1 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 EFA81380.1 - 0.069 12.9 0.1 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SWIM PF04434.17 EFA81381.1 - 0.0016 18.0 0.3 0.0032 17.1 0.3 1.5 1 0 0 1 1 1 1 SWIM zinc finger NOA36 PF06524.12 EFA81381.1 - 0.0065 15.8 14.6 0.01 15.2 14.6 1.4 1 1 0 1 1 1 1 NOA36 protein DNA_pol_phi PF04931.13 EFA81381.1 - 0.031 12.4 19.6 0.035 12.2 19.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EFA81381.1 - 0.033 13.6 17.3 0.038 13.4 17.3 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFA81381.1 - 0.094 10.9 20.5 0.11 10.7 20.5 1.0 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 EFA81381.1 - 0.53 10.0 22.4 0.61 9.8 22.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 EFA81381.1 - 0.61 9.4 17.0 0.72 9.1 17.0 1.1 1 0 0 1 1 1 0 BUD22 CobT PF06213.12 EFA81381.1 - 0.8 9.0 16.0 1 8.7 16.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 EFA81381.1 - 1.9 8.2 10.9 3 7.6 10.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CDC45 PF02724.14 EFA81381.1 - 2.2 6.5 20.6 2.5 6.3 20.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Dicty_REP PF05086.12 EFA81381.1 - 5.2 4.9 12.6 6.5 4.6 12.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TRAP_alpha PF03896.16 EFA81381.1 - 6.4 5.9 9.3 8.8 5.4 9.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pox_Ag35 PF03286.14 EFA81381.1 - 9.6 5.9 12.2 14 5.4 12.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Arf PF00025.21 EFA81382.1 - 1.7e-62 210.0 0.1 1.9e-62 209.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA81382.1 - 3.6e-15 56.2 0.1 4.9e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA81382.1 - 2.2e-13 50.0 0.0 2.6e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA81382.1 - 4.1e-12 46.0 0.0 4.5e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFA81382.1 - 5.1e-11 42.3 0.9 5.5e-09 35.6 0.4 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFA81382.1 - 7.2e-09 35.3 0.0 8.8e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA81382.1 - 2.5e-07 30.8 0.1 3.5e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EFA81382.1 - 0.00023 20.8 0.3 0.15 11.7 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFA81382.1 - 0.0017 18.3 0.1 1.5 8.7 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 EFA81382.1 - 0.0058 16.6 0.5 0.48 10.3 0.5 2.1 1 1 0 1 1 1 1 NACHT domain MeaB PF03308.16 EFA81382.1 - 0.0089 15.0 0.0 0.58 9.1 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFA81382.1 - 0.012 16.1 0.9 0.032 14.7 0.9 1.7 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EFA81382.1 - 0.018 15.2 0.1 0.029 14.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFA81382.1 - 0.036 13.8 0.1 0.87 9.3 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EFA81382.1 - 0.05 13.3 0.4 0.22 11.2 0.1 1.9 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EFA81382.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP11 PF06644.11 EFA81382.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 ATP11 protein AAA_14 PF13173.6 EFA81382.1 - 0.13 12.3 0.1 0.21 11.6 0.1 1.4 1 1 0 1 1 1 0 AAA domain FAM195 PF14799.6 EFA81383.1 - 0.2 12.0 5.9 0.26 11.7 5.9 1.2 1 0 0 1 1 1 0 FAM195 family DNA_pol_phi PF04931.13 EFA81383.1 - 0.23 9.5 11.7 0.28 9.3 11.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi RVT_1 PF00078.27 EFA81385.1 - 2.1e-34 119.0 0.0 3.7e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 EFA81385.1 - 0.0067 16.0 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribonucleas_3_3 PF14622.6 EFA81386.1 - 0.0049 17.0 0.1 0.011 15.9 0.1 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like MCM6_C PF18263.1 EFA81386.1 - 0.039 14.2 0.5 0.8 10.0 0.1 2.4 2 0 0 2 2 2 0 MCM6 C-terminal winged-helix domain AAA PF00004.29 EFA81387.1 - 2.8e-38 131.3 0.0 9.2e-38 129.6 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 EFA81387.1 - 4.1e-12 46.0 0.4 1.1e-11 44.6 0.4 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Vps4_C PF09336.10 EFA81387.1 - 1.2e-06 28.5 0.0 3.3e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFA81387.1 - 2.4e-05 24.0 0.0 5.7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EFA81387.1 - 0.0001 22.1 0.0 0.00027 20.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFA81387.1 - 0.00043 20.4 0.7 0.0015 18.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFA81387.1 - 0.00082 19.4 0.1 0.011 15.7 0.1 2.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFA81387.1 - 0.0019 17.5 0.0 0.0049 16.1 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EFA81387.1 - 0.006 16.8 3.8 0.062 13.6 0.1 3.7 2 1 1 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EFA81387.1 - 0.012 15.1 0.1 0.027 13.8 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF4368 PF14287.6 EFA81387.1 - 0.012 15.8 0.0 0.031 14.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) TniB PF05621.11 EFA81387.1 - 0.023 14.1 0.0 0.49 9.8 0.0 2.5 1 1 1 2 2 2 0 Bacterial TniB protein IstB_IS21 PF01695.17 EFA81387.1 - 0.035 13.8 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DDE_1 PF03184.19 EFA81389.1 - 2.8e-05 23.8 0.0 3.5e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DNase_II PF03265.15 EFA81390.1 - 4.8e-30 104.9 9.2 1.2e-16 61.0 1.8 2.9 2 1 0 2 2 2 2 Deoxyribonuclease II BfiI_DBD PF18243.1 EFA81390.1 - 0.095 12.3 1.2 0.6 9.7 0.0 2.2 2 0 0 2 2 2 0 Metal-independent restriction enzyme BfiI DNA binding domain DDE_Tnp_4 PF13359.6 EFA81391.1 - 2.9e-19 69.3 0.0 2.1e-17 63.2 0.0 2.4 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA81391.1 - 4.5e-07 29.7 0.0 9.3e-07 28.7 0.0 1.5 2 0 0 2 2 2 1 Transposase DDE domain HTH_Tnp_4 PF13613.6 EFA81391.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease SpoIIID PF12116.8 EFA81391.1 - 0.044 13.9 0.0 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 Stage III sporulation protein D Trp_repressor PF01371.19 EFA81391.1 - 0.058 13.5 0.0 8.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Trp repressor protein HTH_23 PF13384.6 EFA81391.1 - 0.095 12.5 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain Rad9 PF04139.13 EFA81392.1 - 1.6e-51 175.2 5.2 1.6e-51 175.2 5.2 2.0 2 0 0 2 2 2 1 Rad9 PCNA_N PF00705.18 EFA81392.1 - 3.6e-05 23.5 1.4 0.0006 19.5 0.2 2.8 3 0 0 3 3 3 1 Proliferating cell nuclear antigen, N-terminal domain TFIIA PF03153.13 EFA81392.1 - 0.0049 16.9 28.9 0.0049 16.9 28.9 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Pannexin_like PF12534.8 EFA81392.1 - 9.8 5.1 18.0 0.032 13.3 5.4 2.5 2 1 0 2 2 2 0 Pannexin-like TM region of LRRC8 EMP70 PF02990.16 EFA81393.1 - 1.2e-108 364.0 17.3 1.2e-108 364.0 17.3 1.5 1 1 0 1 1 1 1 Endomembrane protein 70 DUF5373 PF17343.2 EFA81393.1 - 0.77 9.6 11.1 0.039 13.8 3.7 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5373) Ank_2 PF12796.7 EFA81394.1 - 1.3e-13 51.3 0.0 8.4e-06 26.3 0.0 4.5 4 2 1 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81394.1 - 5.5e-13 49.2 2.1 0.0052 17.3 0.0 6.1 7 1 0 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81394.1 - 3.1e-10 40.1 0.0 0.075 13.4 0.0 5.8 4 2 4 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81394.1 - 9.9e-05 22.5 2.7 43 5.2 0.0 7.6 8 1 1 9 9 9 0 Ankyrin repeat DUF3447 PF11929.8 EFA81394.1 - 0.0032 17.4 3.9 1.7 8.7 0.0 4.9 2 2 2 5 5 5 1 Domain of unknown function (DUF3447) FBA_2 PF07735.17 EFA81394.1 - 0.016 15.3 0.5 0.51 10.5 0.1 2.9 2 0 0 2 2 2 0 F-box associated 7tm_2 PF00002.24 EFA81396.1 - 0.0008 18.8 8.9 0.00097 18.5 8.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Frizzled PF01534.17 EFA81396.1 - 0.019 14.0 12.1 0.025 13.6 12.1 1.1 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region DUF2304 PF10066.9 EFA81396.1 - 1.4 9.2 13.8 2.6 8.3 1.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Ocular_alb PF02101.15 EFA81396.1 - 5.3 5.9 11.2 1.4 7.8 8.0 1.6 1 1 1 2 2 2 0 Ocular albinism type 1 protein Adaptin_N PF01602.20 EFA81397.1 - 5.2e-56 190.3 16.1 5.2e-56 190.3 16.1 2.3 2 1 0 2 2 2 1 Adaptin N terminal region AP4E_app_platf PF14807.6 EFA81397.1 - 6.4e-24 84.2 0.3 2.8e-23 82.2 0.0 2.3 2 0 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.7 EFA81397.1 - 9.4e-08 32.3 1.9 3.2e-07 30.5 0.1 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Coatomer_b_Cpla PF14806.6 EFA81397.1 - 6.2e-06 26.2 0.1 3.1e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform HEAT_EZ PF13513.6 EFA81397.1 - 0.00012 22.4 0.3 0.55 10.8 0.0 3.7 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 EFA81397.1 - 0.0029 18.0 2.7 0.015 15.7 0.3 3.0 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EFA81397.1 - 0.048 13.9 0.1 23 5.6 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat SPG48 PF14764.6 EFA81397.1 - 0.22 12.0 1.7 22 5.6 0.1 3.0 2 0 0 2 2 2 0 AP-5 complex subunit, vesicle trafficking EB PF01683.18 EFA81398.1 - 0.0017 18.6 10.6 0.0017 18.6 10.6 4.8 1 1 2 3 3 3 1 EB module DCP2 PF05026.13 EFA81400.1 - 2.1e-29 101.7 4.6 9.1e-29 99.6 4.6 2.2 1 0 0 1 1 1 1 Dcp2, box A domain SET PF00856.28 EFA81400.1 - 8.1e-15 55.6 7.0 6.2e-14 52.7 0.0 3.2 3 0 0 3 3 3 1 SET domain NUDIX PF00293.28 EFA81400.1 - 5.8e-13 49.0 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain Rubis-subs-bind PF09273.11 EFA81400.1 - 1.7e-05 25.5 1.0 4.8e-05 24.1 1.0 1.8 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Sigma70_r4 PF04545.16 EFA81400.1 - 0.025 14.1 0.1 0.16 11.5 0.1 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 CBP_CCPA PF17040.5 EFA81400.1 - 0.34 11.5 2.9 0.53 10.9 0.2 2.5 2 0 0 2 2 2 0 Cellulose-complementing protein A RNA_pol_Rbc25 PF08292.12 EFA81400.1 - 0.99 9.6 3.7 4.3 7.6 3.7 2.1 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DNase_II PF03265.15 EFA81401.1 - 2.5e-21 76.3 18.1 1.4e-15 57.4 4.1 4.5 3 2 1 4 4 4 3 Deoxyribonuclease II DUF4806 PF16064.5 EFA81401.1 - 0.32 11.3 2.5 0.33 11.3 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) DNase_II PF03265.15 EFA81403.1 - 1.7e-34 119.6 3.3 2e-33 116.0 3.3 2.2 1 1 0 1 1 1 1 Deoxyribonuclease II Ank_4 PF13637.6 EFA81404.1 - 1.1e-13 51.4 1.1 6.7e-06 26.5 0.0 5.1 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81404.1 - 3.6e-09 37.1 1.6 0.0028 18.2 0.1 4.3 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81404.1 - 1.6e-06 28.3 1.3 3.8 8.0 0.0 6.6 3 2 4 8 8 8 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81404.1 - 9.2e-06 25.6 1.5 82 4.3 0.0 7.6 9 0 0 9 9 9 0 Ankyrin repeat DNase_II PF03265.15 EFA81405.1 - 3.8e-36 125.0 5.0 8.8e-21 74.5 0.3 2.3 1 1 0 2 2 2 2 Deoxyribonuclease II Ank_4 PF13637.6 EFA81406.1 - 9.8e-14 51.5 0.9 7.2e-06 26.5 0.0 5.1 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81406.1 - 2.9e-09 37.4 1.5 0.0017 18.9 0.1 4.2 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81406.1 - 9e-07 29.1 1.2 3.8 8.0 0.0 6.6 3 2 5 8 8 8 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81406.1 - 1e-05 25.5 1.5 82 4.3 0.0 7.6 9 0 0 9 9 9 0 Ankyrin repeat DNase_II PF03265.15 EFA81407.1 - 3.6e-45 154.7 7.3 1e-44 153.1 7.3 1.7 1 1 0 1 1 1 1 Deoxyribonuclease II Ank_4 PF13637.6 EFA81408.1 - 1.8e-13 50.7 0.7 4.9e-06 27.0 0.2 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81408.1 - 1.7e-09 37.8 0.5 0.012 15.9 0.0 4.3 1 1 4 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81408.1 - 2.8e-09 37.4 0.2 2.5e-07 31.2 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81408.1 - 1.6e-05 24.9 0.3 3.2 8.6 0.1 4.5 3 1 1 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EFA81409.1 - 2.3e-12 47.2 0.1 2.9e-06 27.7 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81409.1 - 1e-08 35.6 0.2 0.0068 17.0 0.1 3.2 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81409.1 - 1.9e-08 33.9 0.8 0.25 12.0 0.0 6.7 7 0 0 7 7 7 1 Ankyrin repeat Ank_5 PF13857.6 EFA81409.1 - 0.00013 22.2 0.1 6.8 7.1 0.0 4.2 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81410.1 - 1.1e-16 61.1 5.7 6.8e-05 23.4 0.1 3.8 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81410.1 - 5.8e-15 55.5 5.9 0.00037 21.0 0.0 4.8 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81410.1 - 4.9e-13 49.0 3.5 0.22 11.9 0.0 6.7 3 3 4 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81410.1 - 1.4e-07 31.2 3.0 9 7.2 0.0 7.6 7 1 1 8 8 8 1 Ankyrin repeat DUF1540 PF07561.11 EFA81410.1 - 0.083 13.2 0.7 4.1 7.8 0.1 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1540) zf-B_box PF00643.24 EFA81411.1 - 3.7e-05 23.8 5.0 6.4e-05 23.0 5.0 1.4 1 0 0 1 1 1 1 B-box zinc finger LAGLIDADG_1 PF00961.19 EFA81411.1 - 0.99 10.4 8.9 1.4 9.9 8.5 1.5 1 1 0 1 1 1 0 LAGLIDADG endonuclease PIF1 PF05970.14 EFA81412.1 - 1.1e-57 195.9 2.8 1.1e-57 195.9 2.8 3.6 3 1 0 3 3 3 1 PIF1-like helicase AAA_30 PF13604.6 EFA81412.1 - 7.9e-23 81.2 0.0 2e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA81412.1 - 3.3e-12 46.9 0.0 8.9e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA81412.1 - 0.00029 21.1 0.1 0.0017 18.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFA81412.1 - 0.0055 17.1 0.1 0.064 13.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFA81412.1 - 0.017 15.0 2.3 0.042 13.8 0.0 2.6 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFA81412.1 - 0.017 15.5 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain UvrD_C_2 PF13538.6 EFA81412.1 - 0.019 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Mg_chelatase PF01078.21 EFA81412.1 - 0.075 12.4 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Helicase_RecD PF05127.14 EFA81412.1 - 0.13 12.1 0.1 0.13 12.1 0.1 3.2 3 1 0 3 3 3 0 Helicase Ank_2 PF12796.7 EFA81413.1 - 1.1e-09 38.7 0.6 3.4e-06 27.6 0.2 4.3 3 2 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81413.1 - 4e-06 27.3 6.1 0.016 15.7 0.0 4.9 6 0 0 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81413.1 - 3.1e-05 24.0 3.4 13 6.8 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFA81413.1 - 0.024 14.9 15.5 0.43 11.0 0.1 6.1 4 1 2 6 6 6 0 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA81413.1 - 0.042 13.8 0.2 16 5.5 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF5049) TPR_2 PF07719.17 EFA81414.1 - 0.00027 20.8 0.2 0.5 10.6 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81414.1 - 0.0035 17.6 0.1 4.1 7.8 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA81414.1 - 0.006 16.4 3.5 0.26 11.2 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat SUIM_assoc PF16619.5 EFA81414.1 - 0.034 14.2 22.9 0.092 12.8 0.2 3.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TPR_8 PF13181.6 EFA81414.1 - 0.18 12.1 2.4 21 5.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PRIMA1 PF16101.5 EFA81414.1 - 2.6 8.1 8.2 6 6.9 8.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TPR_10 PF13374.6 EFA81414.1 - 6.5 6.8 5.9 1.2e+02 2.8 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat HECT PF00632.25 EFA81416.1 - 2.5e-63 214.4 2.9 9.8e-62 209.2 1.0 3.3 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 EFA81416.1 - 2.5e-17 63.1 0.3 8.1e-17 61.4 0.3 2.0 1 0 0 1 1 1 1 SPRY domain PH PF00169.29 EFA81416.1 - 1.5e-16 60.8 0.1 7.5e-16 58.5 0.1 2.4 1 0 0 1 1 1 1 PH domain CUB PF00431.20 EFA81416.1 - 1.1e-07 32.1 0.0 0.0062 16.9 0.0 3.6 3 0 0 3 3 3 2 CUB domain PH_9 PF15410.6 EFA81416.1 - 1.2e-07 32.1 0.2 4e-07 30.4 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EFA81416.1 - 0.0052 17.0 0.0 0.018 15.3 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Serum_albumin PF00273.20 EFA81416.1 - 0.1 12.4 0.0 1 9.1 0.1 2.4 2 0 0 2 2 2 0 Serum albumin family Methyltransf_16 PF10294.9 EFA81417.1 - 7.8e-14 51.8 0.0 1.2e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Ank_3 PF13606.6 EFA81418.1 - 0.0026 18.1 0.0 14 6.7 0.0 5.0 4 0 0 4 4 4 2 Ankyrin repeat Herpes_UL73 PF03554.13 EFA81419.1 - 8 6.5 8.6 5.3 7.1 3.1 2.3 1 1 1 2 2 2 0 UL73 viral envelope glycoprotein Ank_3 PF13606.6 EFA81420.1 - 0.0094 16.4 0.0 13 6.7 0.0 4.9 3 0 0 3 3 3 1 Ankyrin repeat GRAM PF02893.20 EFA81421.1 - 3.4e-29 101.0 2.8 2.2e-17 63.0 0.3 3.3 2 0 0 2 2 2 2 GRAM domain C2 PF00168.30 EFA81421.1 - 3.4e-17 62.6 0.7 2.5e-09 37.4 0.0 3.4 3 1 1 4 4 4 2 C2 domain bPH_3 PF14470.6 EFA81421.1 - 0.011 16.0 2.0 0.029 14.7 0.4 2.7 2 0 0 2 2 2 0 Bacterial PH domain ubiquitin PF00240.23 EFA81421.1 - 0.02 14.6 0.0 0.16 11.7 0.0 2.7 2 0 0 2 2 2 0 Ubiquitin family DUF2541 PF10807.8 EFA81421.1 - 0.021 14.9 0.1 0.071 13.2 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2541) POB3_N PF17292.2 EFA81421.1 - 0.059 13.8 0.1 0.26 11.7 0.1 2.2 2 0 0 2 2 2 0 POB3-like N-terminal PH domain CENP-B_dimeris PF09026.10 EFA81421.1 - 0.16 12.4 5.5 0.55 10.7 5.5 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4974 PF16344.5 EFA81421.1 - 0.17 11.9 10.5 2.4 8.2 0.4 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4974) Membr_traf_MHD PF10540.9 EFA81421.1 - 1.6 8.9 10.2 0.17 12.1 0.2 3.8 3 1 0 3 3 3 0 Munc13 (mammalian uncoordinated) homology domain DUF3689 PF12463.8 EFA81422.1 - 2e-24 86.5 12.7 2e-24 86.5 12.7 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF3689) FNIP PF05725.12 EFA81423.1 - 1.8e-30 104.8 28.0 3.7e-08 33.4 0.1 8.0 3 2 4 8 8 8 8 FNIP Repeat F-box_5 PF18511.1 EFA81423.1 - 0.0065 16.0 0.2 0.014 14.9 0.2 1.5 1 0 0 1 1 1 1 F-box FNIP PF05725.12 EFA81424.1 - 6.7e-45 151.0 90.1 7.7e-12 45.2 0.4 21.5 14 7 7 23 23 23 15 FNIP Repeat F-box_5 PF18511.1 EFA81424.1 - 8.4e-11 41.3 5.7 0.023 14.2 0.1 3.5 3 0 0 3 3 3 3 F-box F-box-like PF12937.7 EFA81424.1 - 1.4e-06 28.1 6.6 0.25 11.3 0.2 4.0 3 0 0 3 3 3 3 F-box-like TPR_17 PF13431.6 EFA81425.1 - 2.7e-39 130.7 9.1 2.1e-07 30.8 0.1 8.4 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81425.1 - 9.4e-11 41.2 26.0 0.032 13.9 0.1 7.8 8 0 0 8 8 8 5 TPR repeat DUF1153 PF06627.11 EFA81425.1 - 0.13 12.4 0.1 57 3.9 0.0 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF1153) TPR_8 PF13181.6 EFA81425.1 - 0.18 12.1 14.8 27 5.3 0.0 7.6 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA81425.1 - 1.8 8.6 5.6 6.9 6.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat FNIP PF05725.12 EFA81426.1 - 2.4e-28 98.0 20.0 5e-10 39.4 0.1 9.3 7 2 2 9 9 9 7 FNIP Repeat zf-UBR PF02207.20 EFA81427.1 - 5.8e-09 36.0 10.6 5.8e-09 36.0 10.6 3.5 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) Mem_trans PF03547.18 EFA81427.1 - 0.026 12.9 2.2 1.2 7.4 0.2 2.2 2 0 0 2 2 2 0 Membrane transport protein DUF5490 PF17593.2 EFA81427.1 - 0.075 13.1 0.3 0.27 11.3 0.3 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5490) Nop14 PF04147.12 EFA81427.1 - 0.43 8.7 36.1 1.2 7.2 5.0 2.6 2 0 0 2 2 2 0 Nop14-like family UPF0242 PF06785.11 EFA81428.1 - 0.018 15.1 8.1 0.022 14.8 8.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 EFA81428.1 - 0.075 12.1 6.4 0.086 11.9 6.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 EFA81428.1 - 0.43 10.4 8.3 1.2 8.9 8.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF5082 PF16888.5 EFA81428.1 - 1.8 8.8 15.6 0.86 9.9 0.8 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) Swi5 PF07061.11 EFA81428.1 - 1.9 8.6 9.5 2.4 8.3 4.8 2.3 2 0 0 2 2 2 0 Swi5 YabA PF06156.13 EFA81428.1 - 2 9.1 9.1 7.4 7.3 9.1 1.9 1 1 0 1 1 1 0 Initiation control protein YabA FMO-like PF00743.19 EFA81429.1 - 1.9e-51 175.1 0.5 7.5e-38 130.2 0.3 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFA81429.1 - 5.7e-17 61.9 4.4 9.7e-15 54.6 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA81429.1 - 7.7e-15 54.9 0.0 3.5e-12 46.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFA81429.1 - 3.4e-13 49.4 4.5 5.6e-11 42.2 0.4 3.6 4 0 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFA81429.1 - 2.6e-08 33.9 0.0 0.0034 17.0 0.0 3.1 3 0 0 3 3 3 3 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFA81429.1 - 1.2e-05 25.4 0.0 7.6e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFA81429.1 - 1.4e-05 25.3 0.0 4.3e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFA81429.1 - 0.0079 16.7 0.0 0.62 10.7 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFA81429.1 - 0.044 13.1 0.0 0.091 12.1 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase GARS_N PF02844.15 EFA81429.1 - 0.068 14.0 0.0 0.16 12.8 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain Hydrolase_3 PF08282.12 EFA81430.1 - 5.8e-61 206.4 0.2 6.5e-61 206.3 0.2 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EFA81430.1 - 1.7e-15 57.2 1.1 1.6e-09 37.7 0.1 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EFA81430.1 - 7.5e-10 39.4 0.4 0.0014 19.0 0.0 3.2 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA81430.1 - 1.2e-06 29.0 1.5 0.018 15.5 0.0 3.2 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EFA81430.1 - 0.0011 19.0 0.1 0.0061 16.6 0.1 2.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 EFA81430.1 - 0.0075 15.4 0.1 0.45 9.6 0.0 2.1 2 0 0 2 2 2 1 Trehalose-phosphatase HAD_2 PF13419.6 EFA81430.1 - 0.027 14.5 1.3 2.9 7.9 0.0 2.9 3 1 1 4 4 4 0 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EFA81430.1 - 0.033 13.8 0.2 15 5.1 0.0 2.8 2 1 1 3 3 3 0 HAD superfamily, subfamily IIIB (Acid phosphatase) AAA PF00004.29 EFA81431.1 - 5.2e-51 172.5 0.0 3.6e-42 143.9 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) Ribosomal_L17 PF01196.19 EFA81431.1 - 3.5e-30 104.8 0.5 1.1e-29 103.2 0.5 2.0 1 0 0 1 1 1 1 Ribosomal protein L17 Bromodomain PF00439.25 EFA81431.1 - 8.2e-15 54.6 0.6 2.7e-14 53.0 0.6 1.9 1 0 0 1 1 1 1 Bromodomain AAA_lid_3 PF17862.1 EFA81431.1 - 4.1e-07 29.7 0.1 1.1e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFA81431.1 - 2.1e-05 25.0 1.8 0.0004 20.8 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.17 EFA81431.1 - 2.2e-05 24.2 0.0 0.00014 21.6 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 EFA81431.1 - 0.0066 17.0 0.0 0.0066 17.0 0.0 5.2 5 1 0 5 5 2 1 AAA domain AAA_14 PF13173.6 EFA81431.1 - 0.0079 16.2 0.0 0.11 12.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFA81431.1 - 0.01 15.8 0.1 0.11 12.6 0.1 2.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFA81431.1 - 0.023 14.4 0.0 0.076 12.8 0.0 1.9 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 EFA81431.1 - 0.032 14.4 0.3 4.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 EFA81431.1 - 0.036 13.8 0.0 1.5 8.5 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFA81431.1 - 0.044 13.2 0.0 0.13 11.6 0.0 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EFA81431.1 - 0.091 13.0 6.8 0.15 12.3 0.4 3.9 3 1 0 3 3 2 0 AAA domain ABC_tran PF00005.27 EFA81431.1 - 0.1 13.1 0.0 0.1 13.1 0.0 5.3 3 2 0 3 3 1 0 ABC transporter AAA_11 PF13086.6 EFA81431.1 - 1.3 8.8 0.0 1.3 8.8 0.0 7.8 4 2 1 5 5 3 0 AAA domain Methyltransf_4 PF02390.17 EFA81434.1 - 3.2e-36 124.4 0.0 3.2e-36 124.4 0.0 3.0 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_31 PF13847.6 EFA81434.1 - 2.5e-05 24.1 0.0 8.6e-05 22.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA81434.1 - 0.00049 20.8 0.0 0.0021 18.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA81434.1 - 0.02 15.6 0.0 0.02 15.6 0.0 4.8 2 1 2 4 4 4 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFA81434.1 - 0.029 15.0 0.0 0.1 13.3 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain FmrO PF07091.11 EFA81434.1 - 0.14 11.6 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_32 PF13679.6 EFA81434.1 - 0.26 11.3 0.0 0.26 11.3 0.0 3.4 1 1 1 2 2 2 0 Methyltransferase domain TruB_N PF01509.18 EFA81436.1 - 1.3e-25 90.5 0.2 4.7e-12 46.5 0.1 2.4 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EFA81436.1 - 5.2e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 1 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PseudoU_synth_2 PF00849.22 EFA81436.1 - 0.08 13.0 0.0 0.13 12.3 0.0 1.4 1 1 0 1 1 1 0 RNA pseudouridylate synthase DUF3439 PF11921.8 EFA81437.1 - 5.6 7.0 7.0 16 5.5 7.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) BRCT_2 PF16589.5 EFA81438.1 - 2.6e-07 30.9 0.0 5.1e-05 23.6 0.0 3.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA81438.1 - 9.3e-06 25.9 2.0 2.6e-05 24.5 0.0 2.9 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFA81438.1 - 0.0032 17.3 1.9 0.0056 16.5 0.0 2.5 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain Drc1-Sld2 PF11719.8 EFA81439.1 - 0.0026 17.4 7.4 0.0029 17.2 7.4 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein Nop14 PF04147.12 EFA81439.1 - 0.023 12.9 14.0 0.026 12.8 14.0 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EFA81439.1 - 0.025 14.0 12.3 0.026 13.9 12.3 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFA81439.1 - 0.05 11.9 10.5 0.057 11.7 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 EFA81439.1 - 0.6 8.6 12.7 0.77 8.2 12.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 EFA81439.1 - 2.2 7.5 13.1 2.9 7.2 13.1 1.2 1 0 0 1 1 1 0 BUD22 Spt5_N PF11942.8 EFA81439.1 - 2.6 9.1 25.9 1.6 9.8 24.0 1.7 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Rho_N PF07498.12 EFA81441.1 - 0.00019 21.3 0.6 0.00041 20.2 0.6 1.6 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain DUF3439 PF11921.8 EFA81441.1 - 9.1 6.3 7.8 25 4.9 7.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rho_N PF07498.12 EFA81442.1 - 0.001 19.0 0.6 0.0025 17.7 0.6 1.7 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain Mrx7 PF10906.8 EFA81442.1 - 0.12 12.6 2.8 43 4.5 0.0 4.1 4 0 0 4 4 4 0 MIOREX complex component 7 Dicty_REP PF05086.12 EFA81444.1 - 3.6 5.4 6.4 3.6 5.5 6.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EFA81444.1 - 5 5.1 9.7 5.8 4.9 9.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Rho_N PF07498.12 EFA81445.1 - 0.0014 18.5 0.3 0.0024 17.7 0.3 1.4 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain DUF4518 PF15008.6 EFA81445.1 - 0.015 14.5 0.6 0.016 14.4 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) DUF2207 PF09972.9 EFA81446.1 - 0.0049 15.7 2.5 0.0049 15.7 2.5 1.9 1 1 1 2 2 2 1 Predicted membrane protein (DUF2207) DUF4133 PF13571.6 EFA81446.1 - 0.013 15.9 1.0 0.013 15.9 1.0 2.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4133) DUF2070 PF09843.9 EFA81446.1 - 0.3 9.3 6.3 0.36 9.1 6.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Baculo_11_kDa PF06143.11 EFA81446.1 - 0.5 10.0 0.0 0.5 10.0 0.0 3.1 2 1 1 3 3 3 0 Baculovirus 11 kDa family TMEM72 PF16054.5 EFA81446.1 - 0.79 9.4 6.7 1 9.0 1.7 2.2 1 1 1 2 2 2 0 Transmembrane protein family 72 DUF805 PF05656.14 EFA81446.1 - 1.6 9.1 5.5 2.6 8.5 3.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF805) Ndc1_Nup PF09531.10 EFA81446.1 - 2.1 7.0 8.7 3.3 6.3 8.0 1.6 1 1 1 2 2 2 0 Nucleoporin protein Ndc1-Nup Dynamin_N PF00350.23 EFA81448.1 - 3.1e-23 82.7 12.9 4.1e-12 46.5 0.0 4.2 3 2 1 4 4 4 2 Dynamin family MMR_HSR1 PF01926.23 EFA81448.1 - 9.2e-13 48.3 0.1 2.3e-11 43.8 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA81448.1 - 3.1e-05 23.6 0.1 0.067 12.7 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFA81448.1 - 4.8e-05 23.0 0.6 0.00013 21.6 0.0 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EFA81448.1 - 0.002 18.3 2.4 0.0037 17.5 0.0 2.7 3 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFA81448.1 - 0.0034 16.8 0.5 0.0034 16.8 0.5 3.2 2 2 0 2 2 2 1 AIG1 family Ras PF00071.22 EFA81448.1 - 0.015 14.9 0.1 0.12 12.0 0.1 2.3 1 1 0 1 1 1 0 Ras family Septin PF00735.18 EFA81448.1 - 0.016 14.5 3.2 0.21 10.9 0.0 3.2 3 0 0 3 3 3 0 Septin ATP_bind_1 PF03029.17 EFA81448.1 - 0.031 14.0 2.2 1.2 8.8 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 EFA81448.1 - 0.056 12.5 0.1 0.15 11.1 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein F-box-like PF12937.7 EFA81449.1 - 7.7e-08 32.1 0.3 1.6e-07 31.1 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA81449.1 - 3.8e-05 23.4 1.3 0.00021 21.1 1.3 2.3 1 1 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EFA81449.1 - 1.6 9.0 18.9 2.1 8.6 0.5 5.2 5 0 0 5 5 5 0 Leucine Rich repeat partial_CstF PF15861.5 EFA81450.1 - 0.12 12.2 0.3 7 6.5 0.0 3.0 3 0 0 3 3 3 0 Partial cleavage stimulation factor domain AAA_22 PF13401.6 EFA81451.1 - 9.9e-10 38.8 0.2 0.44 10.8 0.0 5.2 5 0 0 5 5 5 3 AAA domain AAA_7 PF12775.7 EFA81451.1 - 3.3e-07 30.0 7.3 0.069 12.7 0.1 5.2 5 0 0 5 5 5 3 P-loop containing dynein motor region AAA PF00004.29 EFA81451.1 - 1.7e-06 28.5 7.5 1.8e-05 25.2 0.0 5.5 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA81451.1 - 0.00048 20.5 0.2 4.6 7.6 0.2 4.3 2 1 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 EFA81451.1 - 0.0043 16.2 0.1 0.011 14.8 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF5343 PF17278.2 EFA81451.1 - 0.046 13.8 2.1 5.8 7.0 0.6 3.5 2 0 0 2 2 2 0 Family of unknown function (DUF5343) Myosin_tail_1 PF01576.19 EFA81453.1 - 0.03 12.1 1.6 0.046 11.5 1.6 1.1 1 0 0 1 1 1 0 Myosin tail Epimerase PF01370.21 EFA81455.1 - 8.6e-15 54.8 0.2 1.6e-14 54.0 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFA81455.1 - 7.9e-13 48.5 0.3 1e-12 48.1 0.3 1.2 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFA81455.1 - 1.2e-12 47.6 0.1 4.9e-12 45.6 0.1 1.8 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EFA81455.1 - 2.4e-12 46.5 0.0 3.1e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFA81455.1 - 7.1e-08 32.6 0.0 9.6e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFA81455.1 - 1.9e-07 30.9 0.2 1.2e-05 25.1 0.1 2.2 2 0 0 2 2 2 1 NmrA-like family RmlD_sub_bind PF04321.17 EFA81455.1 - 0.00042 19.5 0.5 0.00092 18.4 0.5 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Actin PF00022.19 EFA81456.1 - 4.8e-152 506.3 0.0 1.5e-151 504.6 0.0 1.6 1 1 0 1 1 1 1 Actin GATA PF00320.27 EFA81457.1 - 6.4e-16 57.7 4.9 2.1e-15 56.0 4.9 2.0 1 0 0 1 1 1 1 GATA zinc finger Myosin_head PF00063.21 EFA81458.1 - 1.9e-273 908.8 5.2 2.4e-273 908.4 5.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFA81458.1 - 1.4e-39 135.7 5.2 1.6e-39 135.5 3.3 1.9 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.6 EFA81458.1 - 8.7e-16 57.5 0.0 4.9e-15 55.1 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EFA81458.1 - 1.3e-15 56.7 0.1 2.9e-15 55.6 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA81458.1 - 1.4e-11 43.9 0.0 3.4e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain AAA_16 PF13191.6 EFA81458.1 - 0.0017 18.8 0.0 0.0041 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EFA81458.1 - 0.079 13.5 0.3 0.26 11.8 0.3 1.9 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 EFA81458.1 - 0.095 12.0 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Hpr_kinase_C PF07475.12 EFA81458.1 - 0.1 12.1 1.8 0.75 9.3 0.0 2.6 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 EFA81458.1 - 0.12 12.7 0.0 0.45 10.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFA81458.1 - 0.13 12.9 0.1 0.42 11.2 0.0 2.0 2 0 0 2 2 1 0 AAA domain PCMT PF01135.19 EFA81459.1 - 1.1e-28 100.4 0.0 2.8e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) BTB PF00651.31 EFA81459.1 - 2.8e-24 85.5 6.3 2.2e-15 56.8 0.1 4.1 3 1 1 4 4 4 2 BTB/POZ domain Methyltransf_31 PF13847.6 EFA81459.1 - 1.8e-07 31.0 0.6 7.7e-07 29.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.13 EFA81459.1 - 5.2e-06 26.1 0.0 1.6e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Histone methylation protein DOT1 BACK PF07707.15 EFA81459.1 - 0.002 18.2 0.8 0.002 18.2 0.8 2.6 3 0 0 3 3 3 1 BTB And C-terminal Kelch Methyltransf_25 PF13649.6 EFA81459.1 - 0.012 16.3 0.0 0.14 12.8 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFA81459.1 - 0.021 14.2 0.0 0.051 12.9 0.0 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Myticin-prepro PF10690.9 EFA81459.1 - 0.026 14.8 0.2 0.074 13.3 0.2 1.8 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel CNOT11 PF10155.9 EFA81459.1 - 0.091 12.9 2.4 0.11 12.6 0.5 2.1 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 11 Methyltransf_12 PF08242.12 EFA81459.1 - 0.097 13.4 0.0 0.34 11.7 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain DUF3689 PF12463.8 EFA81460.1 - 8e-17 61.5 3.0 2.2e-14 53.5 3.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3689) DUF1492 PF07374.11 EFA81460.1 - 0.012 15.7 0.6 0.37 11.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1492) Acetyltransf_1 PF00583.25 EFA81461.1 - 5.6e-09 36.3 0.0 3.9e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA81461.1 - 3.7e-05 24.1 0.0 7.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA81461.1 - 0.00022 21.1 0.0 0.00052 19.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFA81461.1 - 0.0011 18.6 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA81461.1 - 0.0077 16.9 0.0 0.02 15.6 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FBA_3 PF08268.12 EFA81461.1 - 0.033 14.1 0.0 0.43 10.5 0.0 2.2 2 0 0 2 2 2 0 F-box associated domain FR47 PF08445.10 EFA81461.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Ubiquitin_5 PF18037.1 EFA81461.1 - 0.063 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Ank_2 PF12796.7 EFA81462.1 - 5.2e-28 97.5 17.8 2.2e-06 28.1 0.2 7.5 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81462.1 - 9.8e-27 92.7 13.6 0.0057 17.0 0.1 13.8 5 2 10 15 15 15 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA81462.1 - 3.2e-25 88.1 14.6 0.0014 19.2 0.1 10.3 5 4 7 12 12 12 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81462.1 - 2.3e-12 45.9 7.2 44 5.1 0.0 13.6 16 0 0 16 16 14 0 Ankyrin repeat DUF3447 PF11929.8 EFA81462.1 - 0.0027 17.6 7.0 4.5 7.3 0.0 5.9 4 2 1 6 6 6 1 Domain of unknown function (DUF3447) Ndc80_HEC PF03801.13 EFA81462.1 - 0.0028 17.3 0.1 0.079 12.6 0.0 3.0 3 0 0 3 3 3 1 HEC/Ndc80p family Ank PF00023.30 EFA81462.1 - 0.023 15.1 0.7 2.4e+02 2.4 0.0 6.4 6 4 3 9 9 8 0 Ankyrin repeat Phage_tail_X PF05489.12 EFA81462.1 - 0.079 12.6 0.4 22 4.8 0.0 3.4 2 1 1 3 3 3 0 Phage Tail Protein X FBD PF08387.10 EFA81462.1 - 0.1 12.5 1.3 40 4.2 0.0 4.9 6 0 0 6 6 6 0 FBD DUF4411 PF14367.6 EFA81462.1 - 0.11 12.4 0.6 6.2 6.7 0.0 3.8 3 2 2 5 5 5 0 Domain of unknown function (DUF4411) DUF249 PF03158.13 EFA81462.1 - 0.14 11.8 9.1 5 6.8 0.0 5.2 3 1 3 7 7 7 0 Multigene family 530 protein DUF839 PF05787.13 EFA81462.1 - 0.29 10.3 2.4 2.3 7.3 0.5 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF839) LPD13 PF18825.1 EFA81462.1 - 0.3 10.9 5.0 9.6 6.0 0.1 3.5 5 0 0 5 5 5 0 Large polyvalent protein-associated domain 13 PSRT PF07636.11 EFA81462.1 - 0.37 10.5 1.2 0.5 10.1 0.0 1.7 2 0 0 2 2 2 0 PSRT Tir_receptor_C PF07489.11 EFA81463.1 - 3.6 7.5 10.9 4.1 7.3 10.9 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Med13_C PF06333.12 EFA81463.1 - 8.1 5.6 10.9 9.3 5.4 10.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Ras PF00071.22 EFA81464.1 - 1.3e-50 171.1 0.0 1.6e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA81464.1 - 2.6e-21 76.1 0.0 3.9e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA81464.1 - 1.3e-07 31.3 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA81464.1 - 0.00075 19.1 0.0 0.0047 16.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ANAPC5 PF12862.7 EFA81465.1 - 5.5e-07 29.6 0.4 8.1e-05 22.6 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 ANAPC3 PF12895.7 EFA81465.1 - 0.00021 21.4 5.8 0.27 11.5 0.3 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EFA81465.1 - 0.00047 19.6 0.0 0.011 15.1 0.0 2.2 1 1 0 2 2 2 1 MalT-like TPR region TPR_12 PF13424.6 EFA81465.1 - 0.002 18.4 1.1 5.5 7.4 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA81465.1 - 0.0085 16.1 0.0 5.4 7.3 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81465.1 - 0.026 14.6 1.4 11 6.4 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81465.1 - 0.028 15.2 0.7 15 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt5_N PF11942.8 EFA81465.1 - 0.035 15.1 1.6 0.035 15.1 1.6 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal TPR_8 PF13181.6 EFA81465.1 - 0.066 13.5 0.9 42 4.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4611 PF15387.6 EFA81465.1 - 0.29 11.4 4.3 14 6.0 2.5 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) TatD_DNase PF01026.21 EFA81466.1 - 2.1e-55 187.9 0.0 3.1e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase Cyt-b5 PF00173.28 EFA81466.1 - 9.5e-12 44.9 0.1 1.9e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Amidohydro_2 PF04909.14 EFA81466.1 - 0.014 15.2 0.0 0.026 14.3 0.0 1.6 1 1 0 1 1 1 0 Amidohydrolase Gemini_AL1_M PF08283.11 EFA81466.1 - 0.026 14.6 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 Geminivirus rep protein central domain Spt20 PF12090.8 EFA81466.1 - 0.036 13.7 2.8 0.06 13.0 2.8 1.3 1 0 0 1 1 1 0 Spt20 family RTC PF01137.21 EFA81467.1 - 4.9e-58 195.9 0.0 5.7e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EFA81467.1 - 2.8e-35 121.0 0.0 4e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DDHD PF02862.17 EFA81468.1 - 0.12 12.5 14.1 2.3 8.3 12.6 2.3 2 0 0 2 2 2 0 DDHD domain Med26_M PF15694.5 EFA81468.1 - 3.2 7.7 29.9 0.22 11.6 1.4 2.2 2 0 0 2 2 2 0 Mediator complex subunit 26 middle domain TMEM144 PF07857.12 EFA81469.1 - 0.00041 19.4 0.5 0.00068 18.7 0.5 1.4 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters DEAD PF00270.29 EFA81470.1 - 9.4e-42 142.7 1.4 6.6e-41 140.0 0.0 2.5 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81470.1 - 3.8e-32 110.9 0.3 1.6e-31 108.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Methyltransf_25 PF13649.6 EFA81470.1 - 7.7e-07 29.7 0.0 3.4e-06 27.7 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA81470.1 - 2e-05 24.5 0.0 2e-05 24.5 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA81470.1 - 4.6e-05 24.1 7.4 0.00014 22.5 0.0 3.9 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA81470.1 - 0.0012 19.5 0.0 0.0041 17.7 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain EPL1 PF10513.9 EFA81470.1 - 0.086 13.2 21.8 1.4 9.3 2.3 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like SecA_DEAD PF07517.14 EFA81470.1 - 0.23 10.7 5.6 1.1 8.5 5.6 2.1 1 1 0 1 1 1 0 SecA DEAD-like domain Methyltransf_32 PF13679.6 EFA81470.1 - 1.2 9.1 0.0 1.2 9.1 0.0 3.5 3 0 0 3 3 3 0 Methyltransferase domain DDHD PF02862.17 EFA81470.1 - 1.6 8.8 12.6 4 7.5 0.3 2.4 2 0 0 2 2 2 0 DDHD domain Rsa3 PF14615.6 EFA81472.1 - 0.2 11.3 1.5 0.24 11.0 0.1 1.9 2 0 0 2 2 2 0 Ribosome-assembly protein 3 Ferritin PF00210.24 EFA81473.1 - 0.048 13.6 1.5 0.053 13.5 1.5 1.0 1 0 0 1 1 1 0 Ferritin-like domain ApoO PF09769.9 EFA81473.1 - 0.049 13.6 0.0 0.056 13.4 0.0 1.1 1 0 0 1 1 1 0 Apolipoprotein O Prominin PF05478.11 EFA81473.1 - 0.054 11.5 0.0 0.063 11.2 0.0 1.0 1 0 0 1 1 1 0 Prominin Apolipoprotein PF01442.18 EFA81473.1 - 0.054 13.4 0.2 0.066 13.1 0.2 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain FH2 PF02181.23 EFA81473.1 - 0.071 12.2 0.5 0.082 12.0 0.5 1.0 1 0 0 1 1 1 0 Formin Homology 2 Domain Gp-FAR-1 PF05823.12 EFA81473.1 - 0.1 13.0 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ApoLp-III PF07464.11 EFA81473.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.7 EFA81473.1 - 0.15 12.7 0.1 0.23 12.0 0.1 1.5 1 1 0 1 1 1 0 YtxH-like protein EGF_2 PF07974.13 EFA81474.1 - 7.6e-07 29.4 48.4 0.033 14.6 10.8 3.8 3 0 0 3 3 3 3 EGF-like domain TRP PF06011.12 EFA81474.1 - 0.0024 16.7 34.5 0.0051 15.6 28.1 3.5 1 1 1 2 2 2 1 Transient receptor potential (TRP) ion channel EGF_Tenascin PF18720.1 EFA81474.1 - 0.21 11.6 42.4 0.022 14.8 5.3 4.4 4 1 0 4 4 4 0 Tenascin EGF domain GRAM PF02893.20 EFA81475.1 - 8.7e-44 148.1 13.0 6.2e-20 71.2 0.0 6.0 5 1 0 5 5 5 4 GRAM domain Glyco_transf_28 PF03033.20 EFA81475.1 - 5.3e-26 91.3 0.0 1e-25 90.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 EFA81475.1 - 6.7e-15 55.5 1.1 3.1e-14 53.3 1.1 2.2 1 0 0 1 1 1 1 PH domain FYVE PF01363.21 EFA81475.1 - 2.9e-12 46.5 7.3 5.5e-12 45.6 7.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger UDPGT PF00201.18 EFA81475.1 - 6.7e-08 31.8 0.0 1.2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFA81475.1 - 0.00044 20.3 0.0 0.0011 18.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain bPH_3 PF14470.6 EFA81475.1 - 0.059 13.7 0.0 0.27 11.6 0.0 2.2 1 0 0 1 1 1 0 Bacterial PH domain PH_9 PF15410.6 EFA81475.1 - 0.074 13.4 0.2 0.18 12.1 0.2 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain SspB PF04386.13 EFA81475.1 - 0.12 12.3 0.1 0.63 9.9 0.0 2.2 2 0 0 2 2 2 0 Stringent starvation protein B zinc_ribbon_4 PF13717.6 EFA81475.1 - 0.14 12.1 4.6 0.4 10.6 4.6 1.8 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 EFA81475.1 - 0.15 11.8 5.5 0.056 13.2 2.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain FYVE_2 PF02318.16 EFA81475.1 - 0.29 11.4 7.5 0.63 10.3 7.5 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger IBR PF01485.21 EFA81475.1 - 0.49 10.7 4.5 1.3 9.3 4.5 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-AN1 PF01428.16 EFA81475.1 - 0.87 9.8 9.2 3.6 7.8 9.2 2.0 1 1 1 2 2 2 0 AN1-like Zinc finger C1_4 PF07975.12 EFA81475.1 - 0.89 9.8 4.7 2.9 8.2 4.7 2.0 1 0 0 1 1 1 0 TFIIH C1-like domain zinc_ribbon_10 PF10058.9 EFA81475.1 - 1.8 8.3 4.9 0.37 10.5 0.8 2.0 1 1 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein PH_11 PF15413.6 EFA81475.1 - 3 8.3 9.0 0.14 12.6 1.7 2.6 2 1 0 2 2 1 0 Pleckstrin homology domain DZR PF12773.7 EFA81475.1 - 6.2 6.9 7.2 23 5.1 7.3 1.9 1 1 0 1 1 1 0 Double zinc ribbon ABC2_membrane_3 PF12698.7 EFA81476.1 - 3.2e-30 105.4 30.4 4.5e-30 104.9 30.4 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 EFA81476.1 - 1.7e-29 103.0 0.0 3.3e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA81476.1 - 9.3e-08 32.2 0.4 4e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane PF01061.24 EFA81476.1 - 1.3e-06 28.0 16.7 1.3e-06 28.0 16.7 1.8 2 0 0 2 2 2 1 ABC-2 type transporter SMC_N PF02463.19 EFA81476.1 - 0.00014 21.3 0.2 0.019 14.4 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA81476.1 - 0.028 14.2 0.2 0.067 12.9 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFA81476.1 - 0.031 14.8 1.7 0.033 14.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EFA81476.1 - 0.047 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EFA81476.1 - 0.16 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 EFA81478.1 - 1.7e-74 250.5 0.7 2.7e-74 249.8 0.7 1.3 1 0 0 1 1 1 1 Protein kinase domain SIP1 PF04938.12 EFA81478.1 - 1.3e-67 227.7 1.2 2.3e-67 226.9 1.2 1.4 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Pkinase_Tyr PF07714.17 EFA81478.1 - 9.1e-38 130.0 0.1 1.5e-37 129.3 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFA81478.1 - 7.4e-08 31.7 1.1 7.4e-08 31.7 1.1 1.8 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EFA81478.1 - 4.8e-06 26.1 0.0 8.7e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFA81478.1 - 4.3e-05 22.5 0.7 0.00018 20.4 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 EFA81478.1 - 0.00091 18.6 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFA81478.1 - 0.0013 18.3 1.6 0.003 17.2 1.2 1.7 2 0 0 2 2 2 1 RIO1 family Spt20 PF12090.8 EFA81478.1 - 0.0024 17.5 0.2 0.0024 17.5 0.2 2.4 3 0 0 3 3 3 1 Spt20 family APH PF01636.23 EFA81478.1 - 0.017 15.1 0.8 0.036 14.0 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_C PF00433.24 EFA81478.1 - 0.03 15.0 0.5 0.17 12.6 0.5 2.4 1 0 0 1 1 1 0 Protein kinase C terminal domain Ammonium_transp PF00909.21 EFA81479.1 - 1.8e-110 369.4 26.8 2e-110 369.2 26.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family BT1 PF03092.16 EFA81479.1 - 0.0042 15.4 1.1 0.012 13.9 1.1 1.8 1 0 0 1 1 1 1 BT1 family Aldose_epim PF01263.20 EFA81480.1 - 1.1e-45 156.3 0.1 1.4e-45 155.9 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Pkinase PF00069.25 EFA81481.1 - 1.4e-44 152.5 1.9 1.9e-44 152.0 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain Ribonuc_2-5A PF06479.12 EFA81481.1 - 1.8e-38 131.6 0.0 4.4e-38 130.3 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 EFA81481.1 - 1.1e-26 93.7 0.0 2.3e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA81481.1 - 3.6e-07 29.8 0.0 3.6e-07 29.8 0.0 1.6 2 0 0 2 2 1 1 Kinase-like PQQ_2 PF13360.6 EFA81481.1 - 0.00066 19.3 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 PQQ-like domain Rav1p_C PF12234.8 EFA81481.1 - 0.0045 15.5 2.3 0.0066 14.9 2.3 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal SR-25 PF10500.9 EFA81481.1 - 0.0048 16.5 13.6 0.18 11.4 2.6 2.5 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein FAM176 PF14851.6 EFA81481.1 - 0.038 13.6 0.9 0.11 12.2 0.9 1.7 1 0 0 1 1 1 0 FAM176 family Neur_chan_memb PF02932.16 EFA81481.1 - 0.12 12.4 1.9 0.24 11.4 1.9 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FHIPEP PF00771.20 EFA81481.1 - 0.14 10.6 2.2 0.24 9.8 2.2 1.3 1 0 0 1 1 1 0 FHIPEP family APH PF01636.23 EFA81481.1 - 0.19 11.6 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA81481.1 - 0.23 10.2 10.1 1.1 7.9 10.1 1.9 1 1 0 1 1 1 0 Fungal protein kinase Presenilin PF01080.17 EFA81481.1 - 0.38 9.5 7.1 0.69 8.6 7.1 1.4 1 0 0 1 1 1 0 Presenilin WBP-1 PF11669.8 EFA81481.1 - 0.47 11.1 3.7 1.3 9.6 0.1 2.5 2 0 0 2 2 2 0 WW domain-binding protein 1 OAD_gamma PF04277.13 EFA81481.1 - 0.5 11.0 1.2 3 8.5 0.8 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ctr PF04145.15 EFA81481.1 - 1.9 9.1 5.2 1.3 9.6 1.2 2.5 3 1 0 3 3 2 0 Ctr copper transporter family CLN3 PF02487.17 EFA81481.1 - 3.4 6.6 5.0 1.2 8.1 1.9 1.7 2 0 0 2 2 2 0 CLN3 protein DUF3464 PF11947.8 EFA81481.1 - 4.7 6.9 10.0 13 5.5 10.0 1.7 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 EFA81481.1 - 9.4 6.3 9.0 20 5.2 9.0 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AAT PF03417.16 EFA81482.1 - 9.8e-07 28.7 0.0 5.8e-06 26.2 0.0 2.2 2 1 0 2 2 2 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase CYYR1 PF10873.8 EFA81483.1 - 0.014 15.8 6.3 0.014 15.8 6.3 1.4 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Cadherin_C_2 PF16492.5 EFA81483.1 - 0.038 14.7 2.1 0.082 13.7 0.2 2.1 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal RCR PF12273.8 EFA81483.1 - 0.063 13.9 1.6 0.13 12.9 1.6 1.5 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red SKG6 PF08693.10 EFA81483.1 - 1.1 8.8 4.7 2.7 7.5 0.7 2.6 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF3336 PF11815.8 EFA81484.1 - 2.3e-37 127.8 0.6 4.5e-37 126.9 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EFA81484.1 - 0.00028 21.1 0.0 0.00061 20.0 0.0 1.6 1 1 0 1 1 1 1 Patatin-like phospholipase DUF2139 PF09910.9 EFA81484.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2139) Adipogenin PF15202.6 EFA81484.1 - 3.9 7.6 10.9 36 4.5 10.8 2.4 1 1 0 1 1 1 0 Adipogenin Sec20 PF03908.13 EFA81485.1 - 5.5e-16 58.3 5.2 5.5e-16 58.3 5.2 4.1 4 1 1 5 5 5 1 Sec20 Kelch_6 PF13964.6 EFA81485.1 - 1.7e-06 28.1 0.1 0.085 13.2 0.0 3.7 3 0 0 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA81485.1 - 0.00069 19.7 6.4 0.0013 18.8 6.4 1.5 1 0 0 1 1 1 1 B-box zinc finger nsp8 PF08717.10 EFA81485.1 - 0.0071 16.3 2.4 0.0071 16.3 2.4 2.0 2 0 0 2 2 2 1 nsp8 replicase Strep_SA_rep PF06696.11 EFA81485.1 - 0.16 12.0 1.0 0.33 11.0 1.0 1.5 1 0 0 1 1 1 0 Streptococcal surface antigen repeat Josephin PF02099.17 EFA81486.1 - 1.1e-21 77.6 1.4 1e-20 74.5 1.4 2.0 1 1 0 1 1 1 1 Josephin SAPIS-gp6 PF16722.5 EFA81486.1 - 0.02 15.3 1.7 2.1 8.8 0.0 3.2 3 0 0 3 3 3 0 Pathogenicity island protein gp6 in Staphylococcus TauE PF01925.19 EFA81487.1 - 1.7e-24 86.8 25.1 6.9e-22 78.2 25.0 2.4 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE EB PF01683.18 EFA81487.1 - 1.7 9.0 10.5 3.3 8.1 10.5 1.5 1 0 0 1 1 1 0 EB module DUF4131 PF13567.6 EFA81487.1 - 9.8 5.8 12.8 23 4.6 2.0 3.9 3 1 0 4 4 4 0 Domain of unknown function (DUF4131) Ank_2 PF12796.7 EFA81489.1 - 1.6e-07 31.8 0.2 0.017 15.7 0.0 4.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81489.1 - 0.00048 20.4 0.4 1.5 9.6 0.0 5.8 6 0 0 6 6 6 1 Ankyrin repeat Ank_4 PF13637.6 EFA81489.1 - 0.0017 18.9 1.4 12 6.6 0.0 4.9 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Aa_trans PF01490.18 EFA81490.1 - 2.6e-53 181.2 23.1 3.1e-53 181.0 23.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EF-hand_5 PF13202.6 EFA81492.1 - 5.9e-13 47.7 0.0 0.00022 20.6 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFA81492.1 - 3.7e-12 45.1 0.0 0.0054 16.6 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EFA81492.1 - 2.5e-11 42.3 0.0 0.00059 19.2 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EFA81492.1 - 2.6e-11 43.8 0.0 8.7e-08 32.5 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA81492.1 - 7.9e-06 25.6 0.2 0.00025 20.8 0.0 3.1 3 1 1 4 4 4 1 EF-hand domain pair Ribosomal_L12 PF00542.19 EFA81493.1 - 1.3e-16 60.7 4.3 2.5e-16 59.8 4.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EFA81493.1 - 8.7e-07 28.5 13.4 8.7e-07 28.5 13.4 3.2 3 1 0 3 3 3 2 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EFA81493.1 - 0.016 15.8 4.5 0.024 15.2 0.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein SpoVIF PF14069.6 EFA81493.1 - 0.044 13.6 2.1 0.086 12.6 0.2 2.1 2 0 0 2 2 2 0 Stage VI sporulation protein F Aldedh PF00171.22 EFA81494.1 - 6e-166 552.5 0.0 7.7e-166 552.2 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3487 PF11990.8 EFA81494.1 - 0.03 14.2 0.7 0.17 11.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) MscL PF01741.18 EFA81494.1 - 0.033 14.5 4.6 0.63 10.3 2.3 2.7 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL TMEM154 PF15102.6 EFA81494.1 - 0.22 11.5 4.5 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 TMEM154 protein family SIT PF15330.6 EFA81494.1 - 0.9 10.0 3.3 15 6.0 0.7 3.3 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT Zn_clus PF00172.18 EFA81495.1 - 2.4e-06 27.6 9.7 4.1e-06 26.8 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_3 PF08447.12 EFA81495.1 - 0.11 12.8 0.0 0.4 11.0 0.0 2.0 1 0 0 1 1 1 0 PAS fold PH_3 PF14593.6 EFA81498.1 - 1.3e-15 57.4 0.0 8.1e-15 54.8 0.0 2.5 1 0 0 1 1 1 1 PH domain PH PF00169.29 EFA81498.1 - 5.9e-07 30.0 0.8 3.3e-06 27.6 0.1 2.7 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 EFA81498.1 - 0.042 14.1 0.0 0.25 11.7 0.0 2.4 1 0 0 1 1 1 0 Pleckstrin homology domain A1_Propeptide PF07966.12 EFA81498.1 - 0.087 12.7 1.7 1.1 9.2 0.0 3.1 3 0 0 3 3 3 0 A1 Propeptide Suf PF05843.14 EFA81499.1 - 0.01 15.8 6.5 0.015 15.3 6.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4636 PF15468.6 EFA81499.1 - 0.012 15.3 5.2 0.75 9.4 1.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) EOS1 PF12326.8 EFA81499.1 - 0.1 12.5 3.8 0.17 11.8 3.8 1.3 1 0 0 1 1 1 0 N-glycosylation protein RP-C_C PF11800.8 EFA81499.1 - 8.1 6.5 6.5 0.41 10.7 0.9 1.7 2 0 0 2 2 2 0 Replication protein C C-terminal region TFIIS_M PF07500.14 EFA81500.1 - 1.3e-16 61.0 0.4 1.3e-16 61.0 0.4 1.9 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Med26 PF08711.11 EFA81500.1 - 1.5e-09 37.7 1.7 1.1e-08 35.0 2.6 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Ku_C PF03730.14 EFA81500.1 - 1.6 9.5 12.8 0.12 13.1 4.1 2.5 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm TFIIS_C PF01096.18 EFA81501.1 - 4.4e-19 68.1 8.2 7.5e-19 67.3 7.8 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) zinc_ribbon_12 PF11331.8 EFA81501.1 - 0.12 12.2 3.1 3.7 7.4 0.2 2.5 2 0 0 2 2 2 0 Probable zinc-ribbon domain DUF4379 PF14311.6 EFA81501.1 - 0.5 10.8 4.1 0.4 11.1 1.2 2.1 2 0 0 2 2 2 0 Probable Zinc-ribbon domain C1_4 PF07975.12 EFA81501.1 - 0.53 10.6 5.7 0.84 9.9 1.5 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain Thioredoxin PF00085.20 EFA81502.1 - 0.0011 18.9 0.5 0.0013 18.7 0.5 1.2 1 0 0 1 1 1 1 Thioredoxin Stevor PF17410.2 EFA81503.1 - 0.00087 18.9 1.1 0.00087 18.9 1.1 1.8 2 1 0 2 2 2 1 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 EFA81503.1 - 0.0022 17.9 0.5 0.0022 17.9 0.5 2.3 2 1 0 2 2 2 1 TMEM154 protein family DUF2569 PF10754.9 EFA81503.1 - 0.0068 16.9 0.4 0.0068 16.9 0.4 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF2569) Uroplakin_II PF07353.12 EFA81503.1 - 0.024 14.1 0.2 0.06 12.9 0.2 1.7 1 0 0 1 1 1 0 Uroplakin II Protocadherin PF08374.11 EFA81503.1 - 0.024 14.6 1.6 0.044 13.8 1.6 1.4 1 0 0 1 1 1 0 Protocadherin Sigma_reg_N PF13800.6 EFA81503.1 - 0.038 14.3 17.8 0.44 10.9 4.2 2.7 2 0 0 2 2 2 0 Sigma factor regulator N-terminal IL4Ra_N PF09238.10 EFA81503.1 - 0.067 13.5 1.1 0.14 12.5 0.9 1.6 1 1 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal Orf78 PF06024.12 EFA81503.1 - 0.07 13.4 0.3 0.07 13.4 0.3 2.7 2 1 1 3 3 3 0 Orf78 (ac78) Shisa PF13908.6 EFA81503.1 - 0.073 13.3 0.5 0.13 12.4 0.5 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ASFV_J13L PF05568.11 EFA81503.1 - 0.13 12.1 4.6 1.1 9.0 1.2 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein MAP17 PF15807.5 EFA81503.1 - 0.18 12.0 1.7 0.36 11.0 1.3 1.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EphA2_TM PF14575.6 EFA81503.1 - 0.45 11.4 7.6 0.82 10.6 5.1 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TPR_1 PF00515.28 EFA81504.1 - 2.6e-36 122.0 4.8 2.8e-07 30.1 0.1 10.4 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81504.1 - 7.2e-33 110.0 0.5 5.6e-06 26.1 0.1 10.1 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81504.1 - 2.2e-15 56.1 5.9 0.025 14.2 0.1 8.1 7 1 1 8 8 8 3 TPR repeat TPR_8 PF13181.6 EFA81504.1 - 4.3e-14 51.5 4.7 0.00019 21.4 0.0 8.7 9 2 2 11 11 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA81504.1 - 1.2e-12 48.3 0.0 0.00014 22.4 0.1 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81504.1 - 1.7e-12 47.4 4.9 0.07 13.4 0.2 6.6 3 2 4 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFA81504.1 - 2.3e-10 40.1 8.1 0.0084 16.4 0.0 8.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFA81504.1 - 2.5e-10 40.4 0.3 0.019 15.1 0.1 5.0 3 1 1 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA81504.1 - 1.9e-08 34.2 2.9 0.27 11.4 0.0 4.9 4 0 0 4 4 4 3 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 EFA81504.1 - 2.4e-08 34.1 0.6 3.5 8.7 0.1 6.5 4 2 4 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA81504.1 - 5.8e-08 32.9 4.0 0.12 13.1 0.2 7.1 8 0 0 8 8 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA81504.1 - 3.2e-07 30.5 3.0 0.23 11.7 0.1 4.8 3 1 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFA81504.1 - 1.2e-05 24.9 1.1 0.75 10.0 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA81504.1 - 1.7e-05 25.3 2.0 1.7 9.2 0.0 5.9 4 2 3 7 7 7 2 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFA81504.1 - 0.0007 19.6 2.2 0.072 13.1 0.0 3.4 3 0 0 3 3 3 1 Putative TPR-like repeat TPR_20 PF14561.6 EFA81504.1 - 0.041 14.2 0.7 1.7 9.1 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA81504.1 - 0.053 13.4 0.3 0.52 10.3 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat MRI PF15325.6 EFA81504.1 - 0.13 13.4 1.2 0.27 12.4 1.2 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection Melibiase_2 PF16499.5 EFA81505.1 - 4.5e-70 236.0 5.2 7.5e-70 235.3 5.2 1.4 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EFA81505.1 - 4.1e-19 68.4 0.2 1.4e-18 66.7 0.1 2.0 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EFA81505.1 - 6.7e-07 28.6 0.0 1.9e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Melibiase Melibiase_2_C PF17450.2 EFA81505.1 - 0.0023 18.1 0.6 0.0071 16.6 0.0 2.2 2 0 0 2 2 2 1 Alpha galactosidase A C-terminal beta sandwich domain DUF4407 PF14362.6 EFA81505.1 - 2 7.7 7.5 2.7 7.3 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliD_N PF02465.18 EFA81505.1 - 8.7 7.1 18.1 0.93 10.2 7.4 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Melibiase_2 PF16499.5 EFA81506.1 - 1e-74 251.3 4.4 1.4e-74 250.8 4.4 1.2 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EFA81506.1 - 2.2e-21 75.7 0.4 6.5e-21 74.2 0.2 1.9 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EFA81506.1 - 0.00084 18.4 0.0 0.0015 17.5 0.0 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_30C PF17189.4 EFA81506.1 - 0.026 14.7 0.0 0.054 13.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain Melibiase_2_C PF17450.2 EFA81506.1 - 0.058 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain Radical_SAM PF04055.21 EFA81507.1 - 5.1e-32 111.6 0.1 1.9e-31 109.7 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily UPF0004 PF00919.20 EFA81507.1 - 8.8e-31 105.9 0.1 1.9e-30 104.8 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 EFA81507.1 - 4.3e-07 29.8 0.0 8.7e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 TRAM domain TRAM_2 PF18693.1 EFA81507.1 - 0.16 12.1 0.2 1 9.6 0.2 2.2 1 1 0 1 1 1 0 TRAM domain Amidase PF01425.21 EFA81508.1 - 5e-133 444.3 0.1 5.7e-133 444.2 0.1 1.0 1 0 0 1 1 1 1 Amidase Claudin_2 PF13903.6 EFA81509.1 - 0.23 11.2 0.1 0.33 10.7 0.1 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction RTC PF01137.21 EFA81510.1 - 8.4e-81 270.4 0.1 1e-80 270.1 0.1 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EFA81510.1 - 9.7e-19 67.8 0.0 1.8e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain BP28CT PF08146.12 EFA81511.1 - 0.042 13.7 0.2 0.13 12.1 0.0 1.8 2 1 0 2 2 2 0 BP28CT (NUC211) domain Vac14_Fab1_bd PF12755.7 EFA81511.1 - 0.062 13.9 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region DUF2997 PF11211.8 EFA81511.1 - 0.13 12.1 0.1 0.48 10.3 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) U3snoRNP10 PF12397.8 EFA81512.1 - 2.2e-18 66.7 4.7 2.2e-18 66.7 4.7 6.3 5 1 1 6 6 6 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 EFA81512.1 - 0.0022 18.1 6.0 1 9.8 0.2 4.9 5 0 0 5 5 5 2 HEAT repeat BRF1 PF07741.13 EFA81512.1 - 0.055 13.8 1.0 0.23 11.8 1.0 2.0 1 0 0 1 1 1 0 Brf1-like TBP-binding domain HEAT_2 PF13646.6 EFA81512.1 - 0.62 10.5 4.4 19 5.7 0.1 4.8 5 0 0 5 5 5 0 HEAT repeats HEAT_EZ PF13513.6 EFA81512.1 - 2.8 8.6 4.0 43 4.8 0.2 4.4 6 0 0 6 6 6 0 HEAT-like repeat DNA_primase_S PF01896.19 EFA81513.1 - 9.4e-40 136.5 0.1 1.9e-39 135.5 0.1 1.5 1 0 0 1 1 1 1 DNA primase small subunit Ribosomal_L1 PF00687.21 EFA81514.1 - 3.2e-44 151.1 4.4 3.8e-44 150.9 4.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Fib_alpha PF08702.10 EFA81514.1 - 0.23 11.6 6.7 0.87 9.8 1.8 2.6 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family CLU PF13236.6 EFA81515.1 - 9.6e-58 195.6 0.0 1.8e-57 194.7 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA81515.1 - 0.00028 21.0 1.9 0.0013 18.8 1.2 2.2 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TFIIA PF03153.13 EFA81515.1 - 0.13 12.3 25.0 0.21 11.5 25.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM154 PF15102.6 EFA81517.1 - 5.4e-05 23.1 0.2 5.4e-05 23.1 0.2 4.9 4 1 1 5 5 5 2 TMEM154 protein family Stevor PF17410.2 EFA81517.1 - 0.00037 20.2 7.7 0.046 13.3 0.4 2.8 2 0 0 2 2 2 2 Subtelomeric Variable Open Reading frame Protocadherin PF08374.11 EFA81517.1 - 0.00061 19.8 6.3 0.33 10.9 0.5 2.9 2 0 0 2 2 2 2 Protocadherin COX2_TM PF02790.15 EFA81517.1 - 0.0012 18.9 4.2 0.87 9.8 0.2 3.4 3 0 0 3 3 3 2 Cytochrome C oxidase subunit II, transmembrane domain Promethin PF16015.5 EFA81517.1 - 0.0018 18.2 2.4 0.29 11.1 0.1 2.8 2 0 0 2 2 2 1 Promethin EphA2_TM PF14575.6 EFA81517.1 - 0.0064 17.4 10.7 0.58 11.1 0.3 3.1 3 0 0 3 3 3 2 Ephrin type-A receptor 2 transmembrane domain DUF2569 PF10754.9 EFA81517.1 - 0.0092 16.4 15.7 0.014 15.8 0.6 3.8 4 1 0 4 4 3 2 Protein of unknown function (DUF2569) IL4Ra_N PF09238.10 EFA81517.1 - 0.015 15.6 0.3 0.035 14.4 0.3 1.6 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal Tmemb_14 PF03647.13 EFA81517.1 - 0.035 14.8 1.3 7.4 7.4 0.1 2.9 3 0 0 3 3 3 0 Transmembrane proteins 14C MLANA PF14991.6 EFA81517.1 - 0.079 13.2 4.9 4.6 7.5 0.2 3.1 3 0 0 3 3 3 0 Protein melan-A Sigma_reg_N PF13800.6 EFA81517.1 - 0.092 13.0 26.2 1.4 9.2 2.2 4.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal MAP17 PF15807.5 EFA81517.1 - 0.12 12.6 5.2 1.1 9.5 0.6 2.7 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Orf78 PF06024.12 EFA81517.1 - 0.18 12.1 11.4 0.58 10.5 0.1 3.7 3 1 1 4 4 4 0 Orf78 (ac78) Phage_holin_3_6 PF07332.11 EFA81517.1 - 0.2 11.7 3.5 12 5.9 0.1 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III 7tm_3 PF00003.22 EFA81517.1 - 0.38 10.4 16.0 0.34 10.6 8.4 3.5 3 1 0 3 3 3 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF2615 PF11027.8 EFA81517.1 - 0.64 10.2 4.5 30 4.8 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2615) Shisa PF13908.6 EFA81517.1 - 1.2 9.3 24.3 0.3 11.3 0.2 4.3 3 1 1 4 4 4 0 Wnt and FGF inhibitory regulator DUF2663 PF10864.8 EFA81517.1 - 1.4 9.4 4.5 23 5.4 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2663) DUF2500 PF10694.9 EFA81517.1 - 1.4 9.5 7.9 3 8.4 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) AT_hook PF02178.19 EFA81517.1 - 2.1 8.5 6.7 0.59 10.2 2.8 2.2 2 0 0 2 2 2 0 AT hook motif ASFV_J13L PF05568.11 EFA81517.1 - 3.5 7.3 17.2 4.7 6.9 1.1 3.6 3 0 0 3 3 3 0 African swine fever virus J13L protein ECSCR PF15820.5 EFA81517.1 - 4.6 7.1 22.7 3.7 7.4 4.4 3.8 3 1 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator DUF3149 PF11346.8 EFA81517.1 - 6.6 6.4 18.2 1.1 9.0 1.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3149) RIFIN PF02009.16 EFA81517.1 - 10 5.9 23.2 0.2 11.5 2.0 3.0 2 1 0 3 3 3 0 Rifin TMEM154 PF15102.6 EFA81518.1 - 0.0018 18.2 0.1 0.0018 18.2 0.1 2.4 2 1 0 2 2 2 1 TMEM154 protein family Shisa PF13908.6 EFA81518.1 - 0.0024 18.1 0.2 0.0054 17.0 0.2 1.6 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator IL4Ra_N PF09238.10 EFA81518.1 - 0.011 16.0 0.3 0.022 15.1 0.3 1.6 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal DUF2569 PF10754.9 EFA81518.1 - 0.016 15.7 1.0 0.016 15.7 1.0 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF2569) DUF4448 PF14610.6 EFA81518.1 - 0.064 13.0 1.0 0.089 12.6 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) TIG PF01833.24 EFA81518.1 - 0.85 9.7 11.9 0.15 12.2 0.7 3.0 2 1 0 3 3 3 0 IPT/TIG domain DUF3377 PF11857.8 EFA81518.1 - 1.1 9.3 5.4 0.46 10.4 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Sigma_reg_N PF13800.6 EFA81518.1 - 2.5 8.5 16.1 6.7 7.1 5.5 2.7 2 0 0 2 2 2 0 Sigma factor regulator N-terminal EphA2_TM PF14575.6 EFA81518.1 - 2.9 8.9 5.9 5.2 8.0 3.7 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF3827 PF12877.7 EFA81518.1 - 5.1 5.4 8.8 8.5 4.6 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CTP_transf_like PF01467.26 EFA81519.1 - 2.3e-05 24.6 0.0 4.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like Citrate_synt PF00285.21 EFA81520.1 - 1.6e-109 366.3 0.0 1.8e-109 366.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DENN PF02141.21 EFA81521.1 - 1.7e-32 112.8 9.4 4.1e-28 98.6 1.0 2.7 2 0 0 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 EFA81521.1 - 2.8e-08 34.4 0.2 9.6e-08 32.7 0.2 2.0 1 0 0 1 1 1 1 uDENN domain SPA PF08616.10 EFA81521.1 - 0.00025 21.0 1.5 0.00061 19.7 1.5 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EFA81521.1 - 0.001 17.9 2.0 0.001 17.9 2.0 2.8 2 1 1 3 3 3 1 Transport protein Avl9 DUF3439 PF11921.8 EFA81521.1 - 0.005 16.8 8.2 0.01 15.8 8.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) MIT PF04212.18 EFA81522.1 - 1.6e-07 31.3 1.0 4.8e-07 29.8 1.0 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF1824 PF08854.10 EFA81522.1 - 0.14 12.1 3.0 0.11 12.4 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1824) NRBF2_MIT PF17169.4 EFA81522.1 - 0.42 10.9 2.4 0.39 11.0 0.7 1.8 2 0 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 FNIP PF05725.12 EFA81523.1 - 3.4e-17 62.3 19.2 1.6e-05 25.0 0.0 7.2 6 3 3 9 9 9 6 FNIP Repeat F-box_5 PF18511.1 EFA81523.1 - 9e-06 25.2 0.6 1.6e-05 24.4 0.6 1.3 1 0 0 1 1 1 1 F-box Glyco_hydro_43 PF04616.14 EFA81523.1 - 0.11 11.8 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 Macoilin PF09726.9 EFA81525.1 - 1.3 7.5 11.3 1.4 7.3 11.3 1.0 1 0 0 1 1 1 0 Macoilin family FAM220 PF15487.6 EFA81525.1 - 4 7.0 9.7 5.3 6.6 9.7 1.1 1 0 0 1 1 1 0 FAM220 family Zip PF02535.22 EFA81525.1 - 4.9 6.3 4.9 4.9 6.3 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Apt1 PF10351.9 EFA81525.1 - 9.4 5.0 11.8 9.8 4.9 11.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Uma2 PF05685.12 EFA81526.1 - 0.0064 16.1 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease Rap_GAP PF02145.15 EFA81527.1 - 7e-31 107.2 0.2 7e-31 107.2 0.2 1.9 2 0 0 2 2 2 1 Rap/ran-GAP Roughex PF06020.11 EFA81527.1 - 2 7.4 8.4 4.3 6.3 8.4 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Ank_2 PF12796.7 EFA81528.1 - 3.8e-11 43.4 0.7 3.3e-07 30.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81528.1 - 8.7e-11 42.1 0.7 2.9e-05 24.5 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81528.1 - 6.9e-09 35.2 1.1 0.035 14.6 0.0 6.5 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EFA81528.1 - 1.6e-06 28.3 1.3 0.15 12.4 0.0 4.7 4 2 3 7 7 7 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA81528.1 - 0.14 12.7 0.0 2.8 8.6 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 EFA81529.1 - 3.4e-06 27.5 1.2 0.06 14.0 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81529.1 - 0.00076 19.7 2.6 61 4.7 0.0 5.7 6 0 0 6 6 6 0 Ankyrin repeat Mitochondr_Som1 PF11093.8 EFA81529.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial export protein Som1 DUF4419 PF14388.6 EFA81530.1 - 1.4e-95 320.3 1.9 1.8e-95 319.9 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Ank_2 PF12796.7 EFA81531.1 - 4.4e-11 43.2 2.4 7e-08 33.0 0.0 3.5 2 1 2 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81531.1 - 3.2e-10 40.3 3.2 6.7e-05 23.4 0.1 5.0 3 3 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81531.1 - 3.7e-09 36.1 2.1 0.026 15.1 0.0 7.0 6 1 1 7 7 7 1 Ankyrin repeat Ank_5 PF13857.6 EFA81531.1 - 2.1e-08 34.3 0.3 0.021 15.1 0.0 4.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA81531.1 - 0.011 16.1 0.0 0.2 12.2 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 EFA81532.1 - 5e-12 46.1 1.6 2.7e-05 24.6 0.1 5.0 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81532.1 - 2.5e-11 44.0 0.6 7.8e-08 32.8 0.0 3.3 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81532.1 - 1.4e-09 37.3 5.1 0.035 14.6 0.0 7.4 10 0 0 10 10 10 3 Ankyrin repeat Ank_5 PF13857.6 EFA81532.1 - 4.3e-07 30.1 0.8 0.13 12.7 0.0 4.5 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA81532.1 - 0.1 13.1 0.0 2.9 8.5 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat Ank_2 PF12796.7 EFA81533.1 - 1.8e-12 47.7 0.3 4.4e-07 30.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81533.1 - 1.9e-09 37.0 0.6 0.97 10.2 0.0 6.8 7 1 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EFA81533.1 - 5.2e-08 33.3 2.0 0.0048 17.4 0.0 5.0 3 3 3 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81533.1 - 2.9e-05 24.2 0.7 2 8.8 0.1 5.2 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA81533.1 - 0.03 14.8 0.0 9.6 6.8 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat Ank_2 PF12796.7 EFA81534.1 - 3.7e-10 40.2 0.0 1.4e-07 31.9 0.0 3.6 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81534.1 - 6.7e-09 36.1 0.6 0.022 15.3 0.0 6.2 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81534.1 - 2.3e-08 33.6 0.6 7 7.6 0.0 7.1 8 0 0 8 8 8 2 Ankyrin repeat Ank_5 PF13857.6 EFA81534.1 - 1e-05 25.7 0.2 0.46 10.9 0.0 4.8 3 1 1 4 4 4 1 Ankyrin repeats (many copies) DUF768 PF05589.11 EFA81534.1 - 0.0059 16.6 0.6 1.2 9.2 0.0 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF768) ENTH PF01417.20 EFA81534.1 - 0.14 12.2 0.1 6.7 6.8 0.0 2.9 2 1 0 2 2 2 0 ENTH domain Brix PF04427.18 EFA81535.1 - 6.4e-33 114.5 2.2 1.4e-32 113.3 0.1 2.3 2 0 0 2 2 2 1 Brix domain Sua5_yciO_yrdC PF01300.18 EFA81535.1 - 1.1e-12 47.8 0.0 2.1e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EFA81535.1 - 1.4e-12 48.3 0.0 2.9e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Pkinase PF00069.25 EFA81536.1 - 8.1e-74 248.3 0.0 8.1e-74 248.3 0.0 2.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81536.1 - 4.9e-51 173.5 0.0 1.3e-50 172.1 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFA81536.1 - 0.00052 19.4 0.1 0.0016 17.8 0.1 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFA81536.1 - 0.035 13.7 0.1 0.035 13.7 0.1 2.1 2 0 0 2 2 2 0 RIO1 family VF530 PF09905.9 EFA81536.1 - 0.13 12.5 0.1 0.39 10.9 0.1 1.8 1 0 0 1 1 1 0 DNA-binding protein VF530 TfuA PF07812.12 EFA81536.1 - 0.14 11.9 0.8 0.45 10.3 0.2 2.1 2 0 0 2 2 2 0 TfuA-like protein GNT-I PF03071.15 EFA81537.1 - 2e-76 257.5 6.7 2.6e-76 257.1 6.7 1.0 1 0 0 1 1 1 1 GNT-I family Med29 PF11568.8 EFA81537.1 - 0.011 15.9 2.8 0.025 14.8 0.5 2.1 2 0 0 2 2 2 0 Mediator complex subunit 29 Glyco_tranf_2_3 PF13641.6 EFA81537.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 TPR_MLP1_2 PF07926.12 EFA81537.1 - 1.6 8.8 9.0 0.38 10.8 5.7 1.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF848 PF05852.11 EFA81537.1 - 3.5 7.7 6.1 1.4 9.0 2.7 2.0 3 0 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) RNase_PH PF01138.21 EFA81538.1 - 8.6e-19 68.3 0.0 8.6e-19 68.3 0.0 2.8 3 1 1 4 4 4 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFA81538.1 - 6.2e-10 39.0 0.1 6.2e-10 39.0 0.1 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 SWI-SNF_Ssr4 PF08549.10 EFA81538.1 - 0.013 14.1 22.2 0.017 13.8 22.2 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RTP801_C PF07809.11 EFA81538.1 - 0.078 12.9 1.4 0.11 12.5 0.2 1.9 2 0 0 2 2 2 0 RTP801 C-terminal region PAP1 PF08601.10 EFA81538.1 - 0.48 10.1 24.5 0.7 9.6 24.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 VPS9 PF02204.18 EFA81540.1 - 1.3e-12 47.8 0.2 3.6e-12 46.4 0.2 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain BAR PF03114.18 EFA81540.1 - 0.0025 17.5 3.6 0.14 11.8 0.0 2.6 2 1 0 2 2 2 1 BAR domain Sigma54_activ_2 PF14532.6 EFA81540.1 - 0.25 11.5 2.0 0.34 11.0 0.4 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain PfkB PF00294.24 EFA81541.1 - 1.5e-13 50.8 0.0 8.5e-13 48.3 0.0 2.0 2 0 0 2 2 2 1 pfkB family carbohydrate kinase IBR PF01485.21 EFA81542.1 - 4.2e-22 78.1 41.0 2e-13 50.3 6.2 3.8 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFA81542.1 - 1.3e-05 25.4 9.9 1.3e-05 25.4 9.9 3.7 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA81542.1 - 0.00074 19.3 40.3 0.0012 18.7 7.8 4.0 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) CDC27 PF09507.10 EFA81542.1 - 0.0017 17.9 12.6 0.0017 17.9 12.6 3.0 3 1 0 3 3 3 1 DNA polymerase subunit Cdc27 zf-C3HC4 PF00097.25 EFA81542.1 - 0.0026 17.6 8.6 0.0026 17.6 8.6 4.2 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA81542.1 - 0.0051 16.7 10.2 0.0051 16.7 10.2 3.8 3 0 0 3 3 3 1 zinc-RING finger domain Mucin PF01456.17 EFA81542.1 - 0.063 13.3 28.3 0.13 12.3 4.8 3.7 3 0 0 3 3 3 0 Mucin-like glycoprotein PhnA_Zn_Ribbon PF08274.12 EFA81542.1 - 0.3 11.1 14.2 0.091 12.7 0.4 3.1 2 1 0 2 2 2 0 PhnA Zinc-Ribbon DUF3439 PF11921.8 EFA81542.1 - 0.53 10.3 26.0 1 9.4 3.6 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Treacle PF03546.14 EFA81542.1 - 5.9 5.6 27.3 0.53 9.1 8.2 3.0 2 1 0 2 2 2 0 Treacher Collins syndrome protein Treacle Dus PF01207.17 EFA81543.1 - 5.5e-77 258.9 0.0 7.2e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) EST1 PF10374.9 EFA81543.1 - 0.00035 21.2 0.8 0.00059 20.5 0.8 1.3 1 0 0 1 1 1 1 Telomerase activating protein Est1 ThiG PF05690.14 EFA81543.1 - 0.0014 18.0 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EFA81543.1 - 0.025 14.0 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein NMO PF03060.15 EFA81543.1 - 0.049 13.0 0.0 0.099 12.0 0.0 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase G3P_antiterm PF04309.12 EFA81543.1 - 0.11 12.0 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator DUF1168 PF06658.12 EFA81543.1 - 1.7 8.4 6.4 3 7.7 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PH_3 PF14593.6 EFA81544.1 - 9.6e-10 38.5 0.3 1.5e-09 37.9 0.3 1.2 1 0 0 1 1 1 1 PH domain PH PF00169.29 EFA81544.1 - 1.7e-09 38.1 0.7 2.5e-09 37.6 0.7 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA81544.1 - 5.2 7.5 6.0 84 3.7 6.0 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain Lipase_GDSL PF00657.22 EFA81546.1 - 2.5e-06 27.6 0.2 6.6e-06 26.2 0.2 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase MukB PF04310.12 EFA81546.1 - 0.12 12.2 0.2 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 MukB N-terminal Myb_DNA-binding PF00249.31 EFA81547.1 - 5.2e-11 42.6 0.1 9.1e-11 41.8 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFA81547.1 - 0.0022 17.9 0.1 0.0022 17.9 0.1 4.1 3 1 0 3 3 3 1 Myb DNA-binding like 4F5 PF04419.14 EFA81548.1 - 6.9e-05 23.6 4.1 6.9e-05 23.6 4.1 2.4 2 1 0 2 2 2 1 4F5 protein family CH PF00307.31 EFA81549.1 - 2e-17 63.3 0.0 6.3e-17 61.7 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA81549.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain PAS_10 PF13596.6 EFA81549.1 - 0.065 13.8 0.6 1.7 9.2 0.6 3.6 1 0 0 1 1 1 0 PAS domain SdrD_B PF17210.3 EFA81550.1 - 2.7e-09 37.2 1.1 0.00021 21.5 0.0 3.1 1 1 2 3 3 3 2 SdrD B-like domain DUF2141 PF09912.9 EFA81550.1 - 0.18 11.7 0.9 2 8.4 0.0 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2141) Peptidase_S10 PF00450.22 EFA81551.1 - 4.4e-102 342.6 2.0 5.5e-102 342.3 2.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase LapA_dom PF06305.11 EFA81551.1 - 2.4 8.0 4.6 1.2 9.0 1.6 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain UQ_con PF00179.26 EFA81552.1 - 9e-39 132.3 0.1 1.2e-38 132.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme NAM-associated PF14303.6 EFA81552.1 - 0.23 12.2 5.1 0.32 11.7 5.1 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain RWD PF05773.22 EFA81552.1 - 0.32 11.3 3.7 0.23 11.8 0.8 2.2 1 1 1 2 2 2 0 RWD domain Cwf_Cwc_15 PF04889.12 EFA81552.1 - 1 9.1 11.6 1.3 8.7 11.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TPR_1 PF00515.28 EFA81553.1 - 8.5e-06 25.4 0.2 2e-05 24.2 0.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81553.1 - 5.4e-05 23.0 0.1 0.00014 21.7 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA81553.1 - 0.0046 17.0 0.6 0.0097 16.0 0.6 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 EFA81553.1 - 0.0089 16.7 0.0 0.016 15.8 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA81553.1 - 0.025 14.8 0.1 0.074 13.3 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81553.1 - 0.049 13.9 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA81553.1 - 0.059 13.4 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA81553.1 - 0.11 12.9 0.7 9.2 6.9 0.3 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA81553.1 - 0.13 12.6 1.3 0.24 11.7 0.6 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-RING_2 PF13639.6 EFA81554.1 - 3.4e-11 43.3 6.8 3.4e-11 43.3 6.8 2.3 2 0 0 2 2 2 1 Ring finger domain zinc_ribbon_9 PF14369.6 EFA81554.1 - 4.5e-10 39.6 4.7 4.5e-10 39.6 4.7 2.1 2 0 0 2 2 2 1 zinc-ribbon zf-RING_11 PF17123.5 EFA81554.1 - 3.2e-08 33.2 2.7 3.2e-08 33.2 2.7 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFA81554.1 - 1.6e-07 31.1 7.1 1.6e-07 31.1 7.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA81554.1 - 2.7e-05 24.1 2.4 2.7e-05 24.1 2.4 2.7 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA81554.1 - 3.4e-05 23.7 13.8 0.00014 21.8 4.1 2.4 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA81554.1 - 5.2e-05 23.0 7.1 5.2e-05 23.0 7.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA81554.1 - 7.8e-05 22.9 9.8 7.8e-05 22.9 9.8 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain HypA PF01155.19 EFA81554.1 - 0.00014 21.9 8.4 0.0061 16.6 0.5 2.5 2 1 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_3 PF13920.6 EFA81554.1 - 0.00022 21.0 11.6 0.00031 20.6 3.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA81554.1 - 0.00073 19.3 4.0 0.00073 19.3 4.0 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFA81554.1 - 0.0033 17.4 2.5 0.0033 17.4 2.5 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFA81554.1 - 0.0036 16.9 3.4 0.0036 16.9 3.4 1.8 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type ANAPC_CDC26 PF10471.9 EFA81554.1 - 0.0085 16.9 11.8 0.16 12.8 4.3 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 zf-HC5HC2H_2 PF13832.6 EFA81554.1 - 0.038 14.1 1.0 0.1 12.7 0.3 2.0 1 1 0 1 1 1 0 PHD-zinc-finger like domain zinc_ribbon_16 PF17034.5 EFA81554.1 - 0.054 13.7 2.7 0.14 12.3 0.4 2.5 2 0 0 2 2 2 0 Zinc-ribbon like family Ndc1_Nup PF09531.10 EFA81554.1 - 0.11 11.1 2.0 0.14 10.8 2.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DZR PF12773.7 EFA81554.1 - 0.16 12.0 6.3 3.7 7.7 0.5 2.8 2 1 0 2 2 2 0 Double zinc ribbon Rad50_zn_hook PF04423.14 EFA81554.1 - 0.18 11.6 9.2 0.57 10.1 0.2 2.8 3 0 0 3 3 2 0 Rad50 zinc hook motif zf-RING_6 PF14835.6 EFA81554.1 - 0.18 11.7 3.3 0.28 11.1 0.4 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Prok-RING_1 PF14446.6 EFA81554.1 - 0.32 10.9 14.5 2.1 8.3 1.3 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zinc-ribbons_6 PF07191.12 EFA81554.1 - 0.64 10.0 14.2 0.63 10.1 3.2 3.0 2 1 1 3 3 3 0 zinc-ribbons zf-C2HE PF16278.5 EFA81554.1 - 7.7 7.1 10.5 0.36 11.3 0.3 3.3 2 1 2 4 4 3 0 C2HE / C2H2 / C2HC zinc-binding finger A2L_zn_ribbon PF08792.10 EFA81554.1 - 9.9 6.0 11.7 0.46 10.3 2.0 2.7 3 0 0 3 3 2 0 A2L zinc ribbon domain PB1 PF00564.24 EFA81555.1 - 4.4e-06 26.5 0.1 7.3e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 PB1 domain NTPase_I-T PF01931.18 EFA81556.1 - 4.5e-51 172.9 0.0 5.2e-51 172.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 Peptidase_C1 PF00112.23 EFA81557.1 - 3.8e-65 220.0 7.6 5e-65 219.6 7.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA81557.1 - 7.9e-14 51.8 1.7 1.5e-13 51.0 1.7 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA81557.1 - 1.9e-07 30.3 0.2 0.00086 18.2 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Thioredoxin PF00085.20 EFA81558.1 - 8.1e-23 80.4 0.0 5.6e-22 77.7 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 EFA81558.1 - 0.00081 19.4 1.8 0.0012 18.8 1.2 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EFA81558.1 - 0.0012 19.2 0.0 0.0045 17.4 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin-like domain DUF3150 PF11348.8 EFA81559.1 - 0.19 11.0 4.8 0.25 10.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) DUF4047 PF13256.6 EFA81559.1 - 0.81 9.9 16.2 1.9 8.7 3.5 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4047) DUF1128 PF06569.11 EFA81559.1 - 2.1 8.4 11.0 0.2 11.7 1.3 3.9 4 1 0 4 4 4 0 Protein of unknown function (DUF1128) DUF2120 PF09893.9 EFA81559.1 - 2.3 8.3 7.0 0.59 10.2 2.2 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) TPR_1 PF00515.28 EFA81560.1 - 1.3e-53 176.8 25.0 7.8e-08 31.8 0.0 9.7 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81560.1 - 3.5e-42 139.1 25.0 3.2e-05 23.7 0.0 9.7 9 1 1 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFA81560.1 - 2.3e-34 114.7 26.5 0.00023 21.1 0.0 10.5 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_17 PF13431.6 EFA81560.1 - 2.2e-26 90.3 17.8 0.00016 21.8 0.0 10.4 10 1 1 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81560.1 - 6.4e-24 82.6 0.3 0.012 16.4 0.0 8.5 4 3 4 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81560.1 - 6.7e-22 77.6 15.7 9.1e-06 25.9 1.3 7.0 2 2 4 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 EFA81560.1 - 2.1e-20 73.0 0.5 2.5e-05 24.8 0.0 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFA81560.1 - 6.4e-20 71.4 2.1 0.00032 21.2 0.1 6.6 3 1 3 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81560.1 - 2.6e-15 55.8 28.4 9.1e-05 22.1 0.6 9.1 5 3 4 9 9 9 3 TPR repeat TPR_6 PF13174.6 EFA81560.1 - 4.1e-15 55.3 15.7 0.14 12.9 0.0 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFA81560.1 - 1e-12 47.1 12.1 0.16 12.0 0.0 9.1 8 1 1 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA81560.1 - 4.2e-12 46.1 7.5 5.9e-06 26.4 0.7 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFA81560.1 - 4.4e-10 39.5 0.9 0.017 15.2 0.1 5.8 2 2 5 7 7 7 3 Tetratricopeptide repeat ChAPs PF09295.10 EFA81560.1 - 0.0013 17.8 0.5 0.054 12.5 0.0 3.1 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 EFA81560.1 - 0.72 9.8 8.2 9.9 6.2 0.2 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat BSD PF03909.17 EFA81561.1 - 0.0004 20.3 0.1 0.0004 20.3 0.1 2.1 2 0 0 2 2 2 1 BSD domain DDT PF02791.17 EFA81561.1 - 0.0046 17.2 0.2 0.012 15.9 0.2 1.7 1 0 0 1 1 1 1 DDT domain PGA2 PF07543.12 EFA81561.1 - 6.4 6.8 20.5 0.65 10.0 12.2 2.9 2 0 0 2 2 2 0 Protein trafficking PGA2 SLAIN PF15301.6 EFA81561.1 - 9.3 5.4 17.4 0.068 12.4 5.5 2.7 3 0 0 3 3 3 0 SLAIN motif-containing family Mito_carr PF00153.27 EFA81562.1 - 5.5e-66 218.5 7.0 1.9e-22 79.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RAP1 PF07218.11 EFA81562.1 - 0.014 13.7 0.0 0.021 13.1 0.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Serine_protease PF18405.1 EFA81562.1 - 0.25 10.5 3.0 3.8 6.6 0.0 3.3 2 1 0 3 3 3 0 Gammaproteobacterial serine protease Proteasome PF00227.26 EFA81563.1 - 1.7e-30 105.9 0.0 2.1e-30 105.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Pex16 PF08610.10 EFA81564.1 - 1.6e-37 129.4 0.0 3e-34 118.6 0.0 2.3 1 1 1 2 2 2 2 Peroxisomal membrane protein (Pex16) DUF4820 PF16091.5 EFA81564.1 - 1.3 8.3 3.8 2.1 7.6 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Spt20 PF12090.8 EFA81564.1 - 7.5 6.1 14.5 12 5.4 14.5 1.2 1 0 0 1 1 1 0 Spt20 family Mito_carr PF00153.27 EFA81565.1 - 7.8e-69 227.7 4.2 2.1e-22 78.9 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein 2OG-FeII_Oxy_2 PF13532.6 EFA81566.1 - 2e-28 100.0 0.0 3.1e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIE2_ALG10 PF04922.12 EFA81567.1 - 8.7e-74 249.2 20.5 6.1e-49 167.3 16.9 2.4 1 1 1 2 2 2 2 DIE2/ALG10 family Ank_2 PF12796.7 EFA81567.1 - 0.078 13.6 0.0 1.6 9.4 0.0 2.6 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) TPR_17 PF13431.6 EFA81568.1 - 5.5e-99 317.7 16.0 1.6e-11 43.7 0.0 9.2 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81568.1 - 2.6e-18 65.4 16.8 0.4 10.4 0.1 9.0 9 0 0 9 9 9 8 TPR repeat Anth_Ig PF05587.13 EFA81568.1 - 5e-09 36.4 10.9 12 6.2 0.0 7.9 8 0 0 8 8 8 0 Anthrax receptor extracellular domain P22_CoatProtein PF11651.8 EFA81568.1 - 1e-06 27.7 1.2 0.4 9.2 0.0 5.7 1 1 6 7 7 7 1 P22 coat protein - gene protein 5 Lyx_isomer PF07385.12 EFA81568.1 - 2.5e-06 26.9 1.4 18 4.5 0.0 6.9 2 2 6 8 8 8 0 D-lyxose isomerase YjzC PF14168.6 EFA81568.1 - 1.8e-05 25.0 0.1 12 6.4 0.0 6.4 4 3 5 9 9 9 1 YjzC-like protein DUF3048_C PF17479.2 EFA81568.1 - 0.00019 21.8 5.6 10 6.5 0.7 5.9 2 1 2 5 5 5 1 Protein of unknown function (DUF3048) C-terminal domain DUF1344 PF07076.11 EFA81568.1 - 0.00032 20.6 8.1 14 5.7 0.0 7.7 9 0 0 9 9 9 0 Protein of unknown function (DUF1344) NleF_casp_inhib PF16809.5 EFA81568.1 - 0.00053 19.9 6.6 19 5.2 0.0 6.8 5 3 2 8 8 8 0 NleF caspase inhibitor DUF3255 PF11631.8 EFA81568.1 - 0.017 15.0 10.1 21 5.0 0.0 6.8 1 1 7 8 8 8 0 Protein of unknown function (DUF3255) CNOT1_CAF1_bind PF16415.5 EFA81568.1 - 0.021 14.2 8.4 0.28 10.6 0.2 3.2 1 1 2 3 3 3 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain MIT_C PF16565.5 EFA81568.1 - 0.11 12.5 2.4 5.3 7.0 0.1 3.6 1 1 1 3 3 3 0 Phospholipase D-like domain at C-terminus of MIT TPR_2 PF07719.17 EFA81568.1 - 0.96 9.7 11.1 2.3e+02 2.3 0.0 8.0 10 0 0 10 10 9 0 Tetratricopeptide repeat Sgf11_N PF18519.1 EFA81568.1 - 1.9 8.1 15.3 16 5.1 0.2 5.6 5 0 0 5 5 5 0 SAGA-associated factor 11 N-terminal domain gerPA PF10676.9 EFA81568.1 - 5.2 7.4 25.8 20 5.5 0.7 6.6 6 1 1 7 7 7 0 Spore germination protein gerPA/gerPF DUF4470 PF14737.6 EFA81570.1 - 3.7e-10 39.8 0.0 1.2e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) TPR_2 PF07719.17 EFA81570.1 - 1.3e-06 28.0 4.4 0.00015 21.6 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA81570.1 - 5.7e-06 25.9 6.9 4.5e-05 23.1 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81570.1 - 2.2e-05 24.0 0.8 0.00012 21.7 0.0 2.3 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 EFA81570.1 - 0.00024 21.5 0.4 0.0018 18.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81570.1 - 0.065 14.1 0.0 0.35 11.8 0.0 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA81570.1 - 0.068 13.4 0.3 0.23 11.7 0.3 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 GerD PF17898.1 EFA81570.1 - 0.073 13.0 2.5 14 5.6 0.0 3.0 3 0 0 3 3 3 0 Spore germination GerD central core domain TPR_17 PF13431.6 EFA81570.1 - 0.11 13.0 0.5 0.97 10.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA81570.1 - 0.16 12.3 1.3 2.3 8.7 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81570.1 - 0.61 10.4 1.9 3.7 7.9 0.5 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat UCH PF00443.29 EFA81571.1 - 4.2e-69 232.9 0.0 3.4e-68 229.9 0.0 2.4 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFA81571.1 - 4.6e-21 75.2 0.0 4.6e-21 75.2 0.0 4.1 4 0 0 4 4 4 1 DUSP domain Cullin_binding PF03556.15 EFA81572.1 - 9.8e-29 100.2 0.8 1.9e-28 99.3 0.8 1.5 1 0 0 1 1 1 1 Cullin binding DUF4521 PF15021.6 EFA81572.1 - 0.0081 16.1 5.4 0.022 14.7 3.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4521) Macoilin PF09726.9 EFA81572.1 - 0.06 11.9 7.0 0.066 11.8 7.0 1.1 1 0 0 1 1 1 0 Macoilin family ORC6 PF05460.13 EFA81572.1 - 0.19 10.9 8.2 0.27 10.5 8.2 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ndc1_Nup PF09531.10 EFA81572.1 - 0.65 8.6 4.0 0.83 8.3 4.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFA81572.1 - 1.5 7.5 7.6 1.9 7.1 7.6 1.1 1 0 0 1 1 1 0 Presenilin CCDC106 PF15794.5 EFA81572.1 - 3.4 7.3 8.3 5.3 6.7 8.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 HMA PF00403.26 EFA81573.1 - 1.6e-14 54.0 0.9 2e-14 53.8 0.9 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Fer2_BFD PF04324.15 EFA81573.1 - 0.044 14.1 0.1 0.13 12.6 0.0 1.7 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain DUF1677 PF07911.13 EFA81573.1 - 0.07 13.5 0.0 0.08 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1677) Mo25 PF08569.11 EFA81574.1 - 1.8e-89 300.4 16.7 9.3e-50 169.8 0.6 3.0 2 1 1 3 3 3 3 Mo25-like Metallophos PF00149.28 EFA81575.1 - 8.8e-09 36.2 0.1 6.6e-08 33.3 0.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA81575.1 - 0.00016 21.9 0.0 0.00063 20.0 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PIG-P PF08510.12 EFA81575.1 - 0.76 9.7 12.4 0.075 13.0 4.5 2.9 2 1 1 3 3 3 0 PIG-P MYT1 PF08474.11 EFA81576.1 - 0.1 12.5 4.0 0.14 12.1 4.0 1.1 1 0 0 1 1 1 0 Myelin transcription factor 1 PBP1_TM PF14812.6 EFA81576.1 - 0.75 10.2 6.9 1.2 9.5 6.9 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GST_C_3 PF14497.6 EFA81579.1 - 5.3e-16 58.6 0.0 8.1e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA81579.1 - 0.00079 19.7 0.0 0.0049 17.2 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA81579.1 - 0.00081 19.6 0.1 0.0023 18.1 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA81579.1 - 0.042 13.7 0.0 0.085 12.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Noc2 PF03715.13 EFA81580.1 - 6.9e-103 344.0 5.4 1.5e-102 342.9 3.2 2.2 2 0 0 2 2 2 1 Noc2p family C2 PF00168.30 EFA81581.1 - 1.9e-06 28.1 0.1 4.4e-06 26.9 0.1 1.7 1 1 0 1 1 1 1 C2 domain YceD PF02620.17 EFA81586.1 - 8.8 6.5 11.0 55 3.9 11.0 2.4 1 1 0 1 1 1 0 Large ribosomal RNA subunit accumulation protein YceD WD40 PF00400.32 EFA81587.1 - 2.8e-17 62.7 15.6 1.9e-05 25.3 0.9 7.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA81587.1 - 1e-07 32.1 5.9 0.05 13.9 0.4 5.8 6 2 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA81587.1 - 0.00076 18.9 13.5 0.00084 18.8 0.1 4.3 5 0 0 5 5 5 2 WD40-like domain Ras PF00071.22 EFA81588.1 - 4e-21 75.3 0.6 4.4e-19 68.6 0.4 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFA81588.1 - 1.4e-15 57.6 0.6 1.2e-14 54.6 0.2 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA81588.1 - 1.4e-09 37.7 0.7 7.3e-07 28.8 0.1 2.4 2 1 1 3 3 3 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA81588.1 - 1.1e-06 28.6 0.1 2e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA81588.1 - 0.013 15.0 1.1 0.038 13.5 0.1 2.3 3 0 0 3 3 3 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EFA81588.1 - 0.015 15.4 0.0 0.04 14.0 0.0 1.9 1 0 0 1 1 1 0 Dynamin family RsgA_GTPase PF03193.16 EFA81588.1 - 0.026 14.4 0.0 0.52 10.2 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase Septin PF00735.18 EFA81588.1 - 0.039 13.2 0.0 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 Septin YIF1 PF03878.15 EFA81589.1 - 1.6e-78 263.6 8.5 1.6e-78 263.6 8.5 1.8 2 0 0 2 2 2 1 YIF1 Yip1 PF04893.17 EFA81589.1 - 6.3e-05 22.8 4.7 6.3e-05 22.8 4.7 1.6 2 0 0 2 2 2 1 Yip1 domain DUF4718 PF15842.5 EFA81589.1 - 0.0059 16.4 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4718) ubiquitin PF00240.23 EFA81590.1 - 2.1e-27 94.6 0.2 2.3e-27 94.5 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA81590.1 - 4.3e-17 61.7 0.2 4.7e-17 61.6 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA81590.1 - 1.1e-05 25.8 0.1 3.3e-05 24.2 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA81590.1 - 0.00017 21.4 0.0 0.0002 21.2 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain PAP2 PF01569.21 EFA81591.1 - 2e-24 85.9 2.4 2e-24 85.9 2.4 1.5 2 0 0 2 2 2 1 PAP2 superfamily BLF1 PF17752.1 EFA81591.1 - 0.04 13.2 0.1 0.059 12.7 0.1 1.2 1 0 0 1 1 1 0 Burkholderia lethal factor 1 GIDA PF01134.22 EFA81592.1 - 1.6e-156 521.4 0.8 3.8e-156 520.1 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EFA81592.1 - 1e-65 221.9 0.1 1.6e-65 221.2 0.1 1.3 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 EFA81592.1 - 1.8e-05 24.3 1.3 3.1e-05 23.5 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFA81592.1 - 5.5e-05 22.5 3.0 0.00025 20.4 3.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EFA81592.1 - 0.00092 18.6 1.6 0.0083 15.4 0.6 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EFA81592.1 - 0.0026 16.5 4.1 0.23 10.1 1.2 2.8 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 EFA81592.1 - 0.063 12.4 6.6 0.014 14.5 2.4 1.9 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 EFA81592.1 - 0.3 9.9 3.2 7.5 5.3 0.8 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EFA81592.1 - 0.31 10.0 1.7 1 8.3 1.7 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein DUF4331 PF14224.6 EFA81593.1 - 0.0023 17.2 0.1 0.0054 16.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4331) ETRAMP PF09716.10 EFA81593.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SurA_N_3 PF13624.6 EFA81593.1 - 0.15 11.8 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 SurA N-terminal domain RCC1 PF00415.18 EFA81594.1 - 2.2e-75 249.1 25.5 1.9e-15 57.2 0.1 9.8 9 1 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA81594.1 - 8.7e-40 133.8 40.3 6.9e-08 32.1 0.7 8.2 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat tRNA-synt_1b PF00579.25 EFA81595.1 - 4.8e-63 213.2 0.1 6e-63 212.9 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Macoilin PF09726.9 EFA81596.1 - 1 7.8 14.2 1.5 7.3 14.2 1.2 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 EFA81596.1 - 1.4 8.1 13.4 2.1 7.4 13.4 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Cytomega_UL20A PF05984.12 EFA81596.1 - 6.4 7.1 11.7 0.084 13.2 2.3 2.5 1 1 1 2 2 2 0 Cytomegalovirus UL20A protein DUF4639 PF15479.6 EFA81596.1 - 8.2 5.3 12.4 12 4.7 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) PRP38 PF03371.15 EFA81597.1 - 7.4e-37 126.9 0.0 2.1e-27 96.1 0.0 2.4 1 1 1 2 2 2 2 PRP38 family PH PF00169.29 EFA81598.1 - 1.1e-19 70.9 3.6 4.9e-19 68.8 2.7 2.3 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 EFA81598.1 - 2.5e-10 40.7 2.8 7e-10 39.3 2.8 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EFA81598.1 - 0.0005 20.1 0.9 1.1 9.3 0.1 2.5 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EFA81598.1 - 0.0044 17.4 2.7 0.023 15.0 2.7 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFA81598.1 - 0.0052 17.0 1.2 2.1 8.7 0.4 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain PH_2 PF08458.10 EFA81598.1 - 0.0056 17.0 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 Plant pleckstrin homology-like region DUF2393 PF09624.10 EFA81598.1 - 0.0081 16.2 0.2 0.015 15.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2393) PH_13 PF16652.5 EFA81598.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Wzt_C PF14524.6 EFA81599.1 - 0.0016 18.5 0.0 0.0023 18.0 0.0 1.2 1 0 0 1 1 1 1 Wzt C-terminal domain Pox_I5 PF04713.12 EFA81599.1 - 0.087 12.9 0.7 0.16 12.0 0.7 1.4 1 0 0 1 1 1 0 Poxvirus protein I5 SapB_2 PF03489.17 EFA81599.1 - 0.1 12.7 2.2 7.9 6.7 0.1 3.1 3 0 0 3 3 3 0 Saposin-like type B, region 2 Y_Y_Y PF07495.13 EFA81600.1 - 0.024 14.6 0.3 1.6 8.8 0.0 3.4 3 0 0 3 3 3 0 Y_Y_Y domain Podoplanin PF05808.11 EFA81600.1 - 0.11 12.6 0.1 0.11 12.6 0.1 4.6 3 1 1 4 4 4 0 Podoplanin DUF3338 PF11819.8 EFA81601.1 - 0.73 9.8 9.1 0.11 12.4 1.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF3338) Kinesin PF00225.23 EFA81602.1 - 5.5e-111 370.7 3.0 5.5e-111 370.7 3.0 2.3 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFA81602.1 - 9.9e-26 90.5 3.2 1.1e-25 90.3 0.7 2.4 2 0 0 2 2 2 1 Microtubule binding IstB_IS21 PF01695.17 EFA81602.1 - 0.0075 16.0 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Peptidase_M8 PF01457.16 EFA81603.1 - 1.6e-142 476.0 24.8 5.9e-73 246.3 12.3 4.9 3 2 0 3 3 3 3 Leishmanolysin ID PF18543.1 EFA81603.1 - 0.088 12.8 2.7 5.8 7.0 0.4 2.5 2 0 0 2 2 2 0 Intracellular delivery domain Peptidase_M8 PF01457.16 EFA81604.1 - 2.1e-68 231.3 4.6 3.7e-68 230.5 4.6 1.3 1 1 0 1 1 1 1 Leishmanolysin DUF4953 PF16313.5 EFA81604.1 - 0.0095 15.2 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 1 Met-zincin HIRA_B PF09453.10 EFA81605.1 - 0.0022 17.8 0.6 0.0052 16.6 0.6 1.6 1 0 0 1 1 1 1 HIRA B motif Arf PF00025.21 EFA81606.1 - 1.7e-41 141.5 0.0 2.2e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFA81606.1 - 2.6e-16 59.7 0.0 1.8e-15 56.9 0.0 1.8 1 1 1 2 2 2 1 Ras family Roc PF08477.13 EFA81606.1 - 1e-13 51.6 0.0 1.7e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFA81606.1 - 8.5e-09 35.0 0.4 1e-05 24.9 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFA81606.1 - 1e-07 31.6 0.0 2.2e-07 30.5 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFA81606.1 - 1e-06 28.3 0.0 1.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFA81606.1 - 2.3e-06 27.7 0.1 1.1e-05 25.5 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA81606.1 - 0.00046 19.8 0.0 0.013 15.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EFA81606.1 - 0.057 13.2 0.0 2.5 7.8 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EFA81606.1 - 0.072 12.6 0.2 7 6.2 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B TniB PF05621.11 EFA81606.1 - 0.092 12.1 0.0 0.7 9.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein NOG1 PF06858.14 EFA81606.1 - 0.11 12.3 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) RasGAP PF00616.19 EFA81607.1 - 6.8e-30 104.3 0.1 2e-23 83.2 0.1 4.1 2 2 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase Fzo_mitofusin PF04799.13 EFA81607.1 - 7.8 6.0 12.6 2.8 7.5 2.4 2.7 2 0 0 2 2 2 0 fzo-like conserved region Pkinase PF00069.25 EFA81608.1 - 4.6e-66 222.9 0.0 7.3e-66 222.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81608.1 - 8.8e-53 179.2 0.0 1.3e-52 178.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA81608.1 - 1.6e-07 30.5 0.0 3.7e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Mst1_SARAH PF11629.8 EFA81608.1 - 0.087 12.9 3.2 0.2 11.8 3.2 1.6 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 MMR_HSR1 PF01926.23 EFA81609.1 - 2.5e-09 37.2 0.1 2.5e-09 37.2 0.1 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA81609.1 - 2.7e-08 33.4 0.1 2.7e-08 33.4 0.1 2.2 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFA81609.1 - 1.5e-05 25.0 0.3 1.5e-05 25.0 0.3 2.7 2 1 1 3 3 3 1 RsgA GTPase Phage_HK97_TLTM PF06120.11 EFA81609.1 - 0.0085 15.3 12.5 0.014 14.6 12.5 1.4 1 0 0 1 1 1 1 Tail length tape measure protein ABC_tran PF00005.27 EFA81609.1 - 0.015 15.8 0.0 0.015 15.8 0.0 2.5 2 1 0 2 2 2 0 ABC transporter FeoB_N PF02421.18 EFA81609.1 - 0.018 14.6 1.8 0.02 14.4 0.1 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.6 EFA81609.1 - 0.041 14.3 0.2 0.095 13.1 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain IFNGR1 PF07140.11 EFA81609.1 - 0.045 13.8 0.2 0.045 13.8 0.2 2.2 2 1 0 2 2 2 0 Interferon gamma receptor (IFNGR1) RNA_helicase PF00910.22 EFA81609.1 - 0.055 13.9 0.1 0.055 13.9 0.1 2.5 4 0 0 4 4 2 0 RNA helicase TagA PF12561.8 EFA81609.1 - 0.067 13.6 0.4 0.13 12.7 0.4 1.5 1 1 0 1 1 1 0 ToxR activated gene A lipoprotein domain DUF2730 PF10805.8 EFA81609.1 - 0.1 12.7 10.1 0.1 12.7 3.5 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF2730) AAA_22 PF13401.6 EFA81609.1 - 0.12 12.6 2.9 0.14 12.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 EFA81609.1 - 0.18 11.4 8.8 0.23 11.0 8.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_17 PF13207.6 EFA81609.1 - 0.25 11.8 0.0 0.25 11.8 0.0 3.6 2 1 2 4 4 4 0 AAA domain RPA_C PF08784.11 EFA81609.1 - 0.27 11.9 7.3 0.55 10.9 7.3 1.5 1 0 0 1 1 1 0 Replication protein A C terminal AAA_23 PF13476.6 EFA81609.1 - 0.28 11.6 17.8 1.7 9.1 17.8 2.2 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFA81609.1 - 0.29 10.9 0.1 0.29 10.9 0.1 3.3 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EFA81609.1 - 0.31 11.1 18.1 0.24 11.5 0.4 3.4 2 2 1 3 3 3 0 Dynamin family AAA PF00004.29 EFA81609.1 - 0.35 11.3 0.0 0.35 11.3 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Jnk-SapK_ap_N PF09744.9 EFA81609.1 - 0.37 11.0 22.5 0.22 11.7 20.5 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 AAA_18 PF13238.6 EFA81609.1 - 0.41 11.2 0.0 0.41 11.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 EFA81609.1 - 0.52 9.9 5.1 5.6 6.5 0.1 3.2 1 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain LMBR1 PF04791.16 EFA81609.1 - 1.5 7.6 5.4 1.8 7.4 5.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF745 PF05335.13 EFA81609.1 - 1.9 8.2 19.2 3.2 7.4 19.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CLP1_P PF16575.5 EFA81609.1 - 4.3 7.1 7.1 1.3 8.8 0.1 3.0 2 2 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Tox-ODYAM1 PF15642.6 EFA81609.1 - 5.3 5.9 13.5 2 7.3 10.8 1.6 1 1 1 2 2 2 0 Toxin in Odyssella and Amoebophilus DUF4407 PF14362.6 EFA81609.1 - 8.6 5.6 13.9 13 5.1 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EFA81609.1 - 8.9 7.0 12.5 5.3 7.7 6.9 2.6 2 0 0 2 2 2 0 SlyX MMR_HSR1 PF01926.23 EFA81610.1 - 9.4e-09 35.4 0.1 9.4e-09 35.4 0.1 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA81610.1 - 1.9e-08 33.9 0.3 1.9e-08 33.9 0.3 2.4 1 1 2 3 3 3 1 AIG1 family RsgA_GTPase PF03193.16 EFA81610.1 - 1.9e-05 24.6 0.7 1.9e-05 24.6 0.7 2.7 3 0 0 3 3 3 1 RsgA GTPase FeoB_N PF02421.18 EFA81610.1 - 0.00032 20.3 0.9 0.0019 17.7 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B ABC_tran PF00005.27 EFA81610.1 - 0.0064 17.0 0.0 0.0064 17.0 0.0 2.4 2 1 0 2 2 1 1 ABC transporter AAA PF00004.29 EFA81610.1 - 0.0073 16.7 0.2 0.0073 16.7 0.2 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 EFA81610.1 - 0.0094 15.7 5.2 0.9 9.3 0.2 3.0 2 1 1 3 3 3 2 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 EFA81610.1 - 0.019 15.4 5.7 0.037 14.4 0.1 2.9 1 1 2 3 3 3 0 AAA domain AAA_18 PF13238.6 EFA81610.1 - 0.02 15.5 2.4 0.19 12.3 0.0 3.0 2 1 1 3 3 3 0 AAA domain RNA_helicase PF00910.22 EFA81610.1 - 0.021 15.2 2.6 0.061 13.7 0.1 2.6 3 0 0 3 3 3 0 RNA helicase AAA_16 PF13191.6 EFA81610.1 - 0.034 14.5 0.7 0.39 11.1 0.4 2.5 1 1 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 EFA81610.1 - 0.067 12.2 0.1 0.067 12.2 0.1 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EFA81610.1 - 0.079 13.0 10.1 1.5 8.9 0.1 3.5 2 1 2 4 4 4 0 Dynamin family AAA_33 PF13671.6 EFA81610.1 - 0.14 12.4 6.3 2.8 8.1 1.6 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFA81610.1 - 0.51 10.6 0.1 0.51 10.6 0.1 2.5 2 1 1 3 3 3 0 AAA domain GTP_EFTU PF00009.27 EFA81610.1 - 0.77 9.3 6.4 23 4.4 5.7 3.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 EFA81610.1 - 1.1 9.8 12.7 2.6 8.5 12.7 1.7 1 1 0 1 1 1 0 AAA domain DUF719 PF05334.13 EFA81610.1 - 1.2 9.3 0.0 1.2 9.3 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF719) Pkinase PF00069.25 EFA81611.1 - 6.2e-60 202.8 1.6 5.2e-59 199.8 0.0 3.0 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81611.1 - 5.8e-29 101.1 0.0 4.8e-23 81.8 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase PH PF00169.29 EFA81611.1 - 9.4e-20 71.1 0.5 6.9e-19 68.3 0.0 2.8 2 0 0 2 2 2 1 PH domain PX PF00787.24 EFA81611.1 - 1.8e-18 66.5 0.6 7.3e-18 64.6 0.6 2.1 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.6 EFA81611.1 - 4.6e-06 26.1 0.0 0.00089 18.7 0.0 2.7 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EFA81611.1 - 0.00095 19.2 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family PH_13 PF16652.5 EFA81611.1 - 0.025 14.4 0.2 0.025 14.4 0.2 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain Complex1_LYR PF05347.15 EFA81612.1 - 2.3e-10 40.4 0.0 3e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFA81612.1 - 5.7e-05 23.8 0.1 6.1e-05 23.7 0.1 1.0 1 0 0 1 1 1 1 Complex1_LYR-like Vps35 PF03635.17 EFA81613.1 - 3.5e-259 862.2 26.4 4.1e-259 862.0 26.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 ATP_bind_2 PF03668.15 EFA81613.1 - 0.047 13.0 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family YmgB PF10798.8 EFA81613.1 - 0.13 12.1 1.4 1.6 8.6 0.1 3.1 1 1 1 2 2 2 0 Biofilm development protein YmgB/AriR Cyclin_C_2 PF16899.5 EFA81614.1 - 1.1e-12 48.3 0.0 2.6e-12 47.0 0.0 1.6 2 0 0 2 2 2 1 Cyclin C-terminal domain ARA70 PF12489.8 EFA81614.1 - 0.16 12.1 5.9 0.17 12.1 1.0 2.3 2 1 0 2 2 2 0 Nuclear coactivator tRNA-synt_1g PF09334.11 EFA81615.1 - 2.3e-155 517.2 0.1 3.1e-155 516.8 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA_bind PF01588.20 EFA81615.1 - 3.3e-19 68.8 0.4 7.1e-19 67.7 0.4 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain tRNA-synt_1 PF00133.22 EFA81615.1 - 3.6e-09 35.4 2.2 3.5e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFA81615.1 - 0.00011 22.2 0.1 0.0002 21.3 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zinc-ribbons_6 PF07191.12 EFA81615.1 - 0.12 12.4 4.5 0.22 11.5 4.5 1.4 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.7 EFA81615.1 - 5 7.2 8.2 27 4.9 8.2 2.1 1 1 0 1 1 1 0 Double zinc ribbon CBM49 PF09478.10 EFA81616.1 - 1.9e-12 47.3 1.1 2.6e-12 46.9 1.1 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 PT PF04886.12 EFA81616.1 - 2.2e-08 33.5 8.2 2.2e-08 33.5 8.2 3.6 4 0 0 4 4 4 1 PT repeat AF-4 PF05110.13 EFA81617.1 - 0.00013 20.2 6.5 0.00025 19.3 6.5 1.4 1 0 0 1 1 1 1 AF-4 proto-oncoprotein DUF3430 PF11912.8 EFA81618.1 - 6.6e-17 62.3 21.0 2.2e-10 40.9 4.6 4.4 3 1 2 5 5 5 2 Protein of unknown function (DUF3430) Ribonuc_red_sm PF00268.21 EFA81619.1 - 6.6e-63 212.8 9.5 3.7e-60 203.8 6.5 2.3 2 0 0 2 2 2 2 Ribonucleotide reductase, small chain GDPD PF03009.17 EFA81619.1 - 1.7e-50 172.2 0.1 3.7e-50 171.0 0.1 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family HEAT_2 PF13646.6 EFA81619.1 - 1.5e-27 95.8 5.7 2.1e-13 50.5 0.2 2.9 2 0 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 EFA81619.1 - 7.1e-23 78.9 0.7 0.0001 22.7 0.0 6.5 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat CBM_20 PF00686.19 EFA81619.1 - 5.5e-18 64.7 0.9 1.1e-17 63.7 0.2 1.8 2 0 0 2 2 2 1 Starch binding domain HEAT PF02985.22 EFA81619.1 - 9.8e-10 37.9 1.9 0.042 14.1 0.1 5.3 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 EFA81619.1 - 6.8e-05 23.3 1.2 0.52 10.9 0.1 3.6 3 0 0 3 3 3 1 HEAT-like repeat Arm PF00514.23 EFA81619.1 - 0.026 14.6 0.2 6.9 6.9 0.0 2.9 2 1 0 2 2 2 0 Armadillo/beta-catenin-like repeat DUF4744 PF15918.5 EFA81619.1 - 0.046 14.6 0.1 0.17 12.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) Cnd1 PF12717.7 EFA81619.1 - 0.3 11.1 4.0 1.9 8.5 0.0 3.9 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 DnaJ_C PF01556.18 EFA81620.1 - 3.6e-37 127.7 0.8 4.8e-37 127.3 0.8 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFA81620.1 - 1.9e-28 98.3 3.2 3.5e-28 97.5 3.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFA81620.1 - 7e-15 55.1 17.0 1.6e-14 54.0 17.0 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFA81620.1 - 2e-10 40.5 15.3 3.8e-05 23.6 3.2 2.6 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EFA81620.1 - 0.0004 20.4 10.5 0.045 13.8 2.5 2.5 1 1 1 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 EFA81620.1 - 0.0015 18.2 3.3 0.27 10.9 0.2 2.4 2 0 0 2 2 2 2 Thaumarchaeal output domain 1 TFIIS_C PF01096.18 EFA81620.1 - 0.067 13.0 0.3 0.067 13.0 0.3 3.9 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.6 EFA81620.1 - 0.088 13.2 9.2 0.18 12.2 1.6 3.2 1 1 2 3 3 3 0 Restriction alleviation protein Lar DZR PF12773.7 EFA81620.1 - 0.81 9.8 13.5 2.4 8.2 9.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 EFA81620.1 - 0.95 9.5 11.3 2.4 8.2 5.9 3.0 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zinc-ribbons_6 PF07191.12 EFA81620.1 - 1.1 9.3 10.0 26 4.9 1.4 2.6 1 1 1 2 2 2 0 zinc-ribbons zinc_ribbon_9 PF14369.6 EFA81620.1 - 3.1 8.1 12.2 11 6.4 0.1 4.2 3 1 0 3 3 3 0 zinc-ribbon zf-C4_Topoisom PF01396.19 EFA81620.1 - 6.6 6.6 9.4 30 4.5 0.1 3.7 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Cytochrom_c3_2 PF14537.6 EFA81620.1 - 7.2 7.2 9.5 1.2e+02 3.2 1.7 2.7 1 1 1 2 2 2 0 Cytochrome c3 COesterase PF00135.28 EFA81621.1 - 5.2e-100 335.7 0.0 5.2e-100 335.7 0.0 4.0 2 2 1 3 3 3 1 Carboxylesterase family Neugrin PF06413.11 EFA81621.1 - 7.9e-11 42.4 0.9 7.9e-11 42.4 0.9 3.0 3 0 0 3 3 3 1 Neugrin MRP-L20 PF12824.7 EFA81621.1 - 0.00012 22.3 5.0 0.00021 21.5 2.9 2.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Abhydrolase_3 PF07859.13 EFA81621.1 - 0.00017 21.5 0.1 0.00054 19.9 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Beta_helix PF13229.6 EFA81622.1 - 6.7e-45 152.8 56.7 1.8e-19 70.1 17.6 3.4 1 1 2 3 3 3 3 Right handed beta helix region NosD PF05048.13 EFA81622.1 - 1.1e-28 100.2 61.3 8.4e-14 51.4 16.9 3.6 1 1 2 3 3 3 3 Periplasmic copper-binding protein (NosD) zf-UBR PF02207.20 EFA81622.1 - 5.2e-08 32.9 14.2 1.7e-07 31.3 14.2 1.9 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) F-box PF00646.33 EFA81622.1 - 1.4e-06 28.0 0.3 3.2e-06 26.9 0.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA81622.1 - 0.012 15.5 0.1 0.028 14.3 0.1 1.6 1 0 0 1 1 1 0 F-box-like Peptidase_M41 PF01434.18 EFA81624.1 - 1.1e-45 155.9 0.3 1.1e-45 155.9 0.3 2.3 2 1 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EFA81624.1 - 1.4e-43 148.5 0.0 3.7e-41 140.6 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EFA81624.1 - 7.5e-12 45.5 0.2 0.00024 21.3 0.0 4.1 2 2 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA81624.1 - 1e-09 38.2 2.3 5e-06 26.2 0.0 3.6 3 1 1 4 4 4 2 Ras family AAA_lid_3 PF17862.1 EFA81624.1 - 2.6e-09 36.7 0.0 7e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFA81624.1 - 4.6e-07 30.4 0.0 0.018 15.4 0.0 3.4 2 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFA81624.1 - 1.7e-05 25.1 0.5 0.49 10.7 0.1 4.2 3 1 0 4 4 3 1 AAA domain MMR_HSR1 PF01926.23 EFA81624.1 - 2.7e-05 24.2 2.3 0.0024 17.9 0.4 3.9 3 1 1 4 4 4 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EFA81624.1 - 4.2e-05 23.4 0.4 0.63 9.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain Arf PF00025.21 EFA81624.1 - 5.4e-05 22.7 0.1 0.16 11.4 0.1 3.0 2 1 1 3 3 3 2 ADP-ribosylation factor family AAA_5 PF07728.14 EFA81624.1 - 6.8e-05 22.9 0.0 0.00072 19.6 0.0 2.7 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFA81624.1 - 6.8e-05 22.5 0.2 0.51 9.8 0.0 3.3 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 EFA81624.1 - 0.00016 21.7 0.0 0.2 11.7 0.0 3.2 3 0 0 3 3 2 1 AAA domain GTP_EFTU PF00009.27 EFA81624.1 - 0.00031 20.3 0.1 1 8.8 0.0 3.3 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain RuvB_N PF05496.12 EFA81624.1 - 0.00051 19.8 0.0 0.002 17.9 0.0 2.0 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain FeoB_N PF02421.18 EFA81624.1 - 0.00084 18.9 0.5 0.022 14.3 0.1 2.9 3 0 0 3 3 2 1 Ferrous iron transport protein B AAA_2 PF07724.14 EFA81624.1 - 0.0016 18.6 0.0 0.45 10.6 0.0 3.0 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EFA81624.1 - 0.0018 18.0 0.0 0.13 11.9 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain TniB PF05621.11 EFA81624.1 - 0.0018 17.7 0.0 0.22 10.9 0.0 3.4 3 0 0 3 3 3 1 Bacterial TniB protein RNA_helicase PF00910.22 EFA81624.1 - 0.0019 18.6 0.0 1.4 9.3 0.0 3.3 2 1 0 2 2 2 1 RNA helicase ATPase PF06745.13 EFA81624.1 - 0.0025 17.2 0.1 0.4 10.0 0.0 3.3 3 0 0 3 3 3 1 KaiC AAA_18 PF13238.6 EFA81624.1 - 0.0025 18.4 0.6 1.3 9.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 EFA81624.1 - 0.0034 16.6 0.0 0.0075 15.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain RsgA_GTPase PF03193.16 EFA81624.1 - 0.0036 17.2 0.0 1.9 8.4 0.0 3.5 3 0 0 3 3 3 1 RsgA GTPase Holin_BhlA PF10960.8 EFA81624.1 - 0.0058 16.6 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 BhlA holin family PduV-EutP PF10662.9 EFA81624.1 - 0.0063 16.3 0.0 1.6 8.5 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 EFA81624.1 - 0.0093 15.7 0.0 0.23 11.2 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein SecA_DEAD PF07517.14 EFA81624.1 - 0.011 15.0 0.3 0.23 10.7 0.2 2.4 1 1 0 2 2 2 0 SecA DEAD-like domain TsaE PF02367.17 EFA81624.1 - 0.011 15.7 0.0 0.13 12.2 0.0 2.5 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRPRB PF09439.10 EFA81624.1 - 0.016 14.6 1.2 0.59 9.5 0.0 3.6 3 1 0 3 3 3 0 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.12 EFA81624.1 - 0.026 13.8 0.0 0.078 12.3 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.21 EFA81624.1 - 0.05 13.0 0.1 0.14 11.5 0.1 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DEAD PF00270.29 EFA81624.1 - 0.072 12.9 0.4 2.9 7.6 0.0 2.8 3 0 0 3 3 2 0 DEAD/DEAH box helicase Herpes_U59 PF04529.12 EFA81624.1 - 0.12 11.5 0.7 0.38 9.7 0.1 1.9 2 0 0 2 2 2 0 Herpesvirus U59 protein NACHT PF05729.12 EFA81624.1 - 0.18 11.7 0.5 0.85 9.5 0.1 2.3 3 0 0 3 3 2 0 NACHT domain Dynamin_N PF00350.23 EFA81624.1 - 0.19 11.8 4.1 0.35 10.9 0.0 3.2 3 1 1 4 4 3 0 Dynamin family PDCD2_C PF04194.13 EFA81624.1 - 0.45 10.6 4.4 0.078 13.0 0.3 1.7 2 0 0 2 2 1 0 Programmed cell death protein 2, C-terminal putative domain ABC_tran PF00005.27 EFA81624.1 - 0.54 10.8 4.8 4.3 7.9 0.1 3.6 3 1 1 4 4 3 0 ABC transporter DNA_pol_A PF00476.20 EFA81626.1 - 3.2e-99 332.5 0.7 3.2e-99 332.5 0.7 1.8 2 0 0 2 2 2 1 DNA polymerase family A DUF4684 PF15736.5 EFA81626.1 - 1.8 7.1 3.7 2.9 6.5 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4684) CSRNP_N PF16019.5 EFA81626.1 - 3.7 7.4 22.8 0.31 10.9 4.3 3.4 3 0 0 3 3 3 0 Cysteine/serine-rich nuclear protein N-terminus BTB PF00651.31 EFA81627.1 - 2.7e-19 69.4 2.0 1.1e-14 54.7 0.4 2.8 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 EFA81627.1 - 4e-11 42.9 2.5 1.2e-08 35.0 0.8 3.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch F5_F8_type_C PF00754.25 EFA81627.1 - 0.052 13.7 0.0 0.096 12.8 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain PWWP PF00855.17 EFA81628.1 - 6.2e-14 52.2 1.1 6.2e-14 52.2 1.1 3.8 4 2 0 4 4 4 1 PWWP domain VPS9 PF02204.18 EFA81629.1 - 2.8e-25 88.5 2.7 1.8e-24 85.9 0.8 2.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EFA81629.1 - 1.8e-05 24.9 1.5 0.00013 22.3 1.5 2.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) KIX PF02172.16 EFA81629.1 - 0.0016 18.7 0.0 0.005 17.1 0.0 1.8 1 0 0 1 1 1 1 KIX domain FUN14 PF04930.15 EFA81629.1 - 0.32 11.4 0.1 0.32 11.4 0.1 2.3 2 0 0 2 2 2 0 FUN14 family DUF641 PF04859.12 EFA81629.1 - 0.64 10.4 8.1 0.099 13.0 2.7 2.6 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) DUF2203 PF09969.9 EFA81629.1 - 3.1 8.6 6.1 9.3 7.0 0.0 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Ribosomal_S15 PF00312.22 EFA81630.1 - 9e-26 89.9 2.5 2.1e-25 88.7 2.5 1.7 1 0 0 1 1 1 1 Ribosomal protein S15 DUF1461 PF07314.11 EFA81630.1 - 0.11 12.4 0.4 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) Ribophorin_II PF05817.14 EFA81631.1 - 3.1e-139 465.4 9.4 3.6e-139 465.2 9.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Phage_sheath_1N PF17481.2 EFA81631.1 - 0.43 11.1 2.5 2.3 8.7 2.5 2.2 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain PhyH PF05721.13 EFA81632.1 - 3.9e-08 33.8 0.1 7.9e-05 23.0 0.1 3.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFA81632.1 - 0.022 13.6 0.1 0.074 11.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EFA81632.1 - 0.073 13.5 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Ank_2 PF12796.7 EFA81633.1 - 8.4e-30 103.2 11.8 2.9e-05 24.5 0.0 6.5 2 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81633.1 - 2.2e-27 94.7 17.1 3e-05 24.2 0.0 12.1 4 4 8 13 13 13 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA81633.1 - 5.7e-27 93.8 11.5 0.00041 20.9 0.0 9.3 6 1 2 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81633.1 - 1.6e-20 71.0 8.6 1.9 9.3 0.0 13.2 13 1 1 14 14 14 6 Ankyrin repeat Ank PF00023.30 EFA81633.1 - 0.029 14.8 0.3 56 4.4 0.0 5.3 5 0 0 5 5 5 0 Ankyrin repeat DUF3447 PF11929.8 EFA81633.1 - 0.3 11.1 29.1 0.12 12.3 0.8 7.1 4 2 3 7 7 7 0 Domain of unknown function (DUF3447) PhaG_MnhG_YufB PF03334.14 EFA81634.1 - 4 7.8 10.7 0.17 12.1 3.0 2.6 3 1 0 3 3 3 0 Na+/H+ antiporter subunit Mito_carr PF00153.27 EFA81635.1 - 3.7e-71 235.1 0.8 8.9e-25 86.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4199 PF13858.6 EFA81635.1 - 0.23 11.8 2.0 0.31 11.4 0.6 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) TPR_1 PF00515.28 EFA81636.1 - 1.3e-22 78.6 22.5 1.9e-05 24.3 1.2 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81636.1 - 1.2e-21 75.0 16.3 0.00051 19.9 0.6 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFA81636.1 - 3.7e-11 43.2 10.2 0.00021 21.5 1.3 5.1 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA81636.1 - 7.7e-09 36.1 1.8 0.18 12.4 0.0 3.6 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFA81636.1 - 2.9e-07 30.9 3.9 0.0011 19.4 0.0 4.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA81636.1 - 1.7e-06 27.8 21.6 1.4 9.3 0.2 7.1 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81636.1 - 9.4e-06 26.0 0.8 4.5 8.3 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFA81636.1 - 1.9e-05 24.4 7.0 1.5 8.8 0.2 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA81636.1 - 2.9e-05 23.6 20.8 0.0093 15.6 1.5 5.2 4 1 1 5 5 5 3 TPR repeat SHNi-TPR PF10516.9 EFA81636.1 - 0.0011 18.3 3.2 0.055 12.9 0.2 4.2 5 1 0 5 5 5 1 SHNi-TPR DUF3856 PF12968.7 EFA81636.1 - 0.022 14.9 3.0 10 6.2 0.0 3.5 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) DUF3439 PF11921.8 EFA81636.1 - 0.12 12.3 6.4 0.29 11.1 6.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TPR_7 PF13176.6 EFA81636.1 - 0.13 12.4 6.6 54 4.2 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 EFA81636.1 - 0.51 10.4 16.0 0.37 10.9 1.9 4.5 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_20 PF14561.6 EFA81636.1 - 0.78 10.1 5.3 2.6 8.4 0.5 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA81636.1 - 1.4 9.5 18.5 2.2 8.8 0.1 5.2 6 0 0 6 6 4 0 Tetratricopeptide repeat DUF3300 PF11737.8 EFA81636.1 - 5 6.6 14.1 0.025 14.1 4.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) Dynactin_p22 PF07426.11 EFA81637.1 - 3.3e-20 72.6 14.6 3.5e-20 72.5 9.9 2.3 1 1 0 2 2 2 1 Dynactin subunit p22 Med2 PF11214.8 EFA81637.1 - 0.00049 20.2 6.1 0.12 12.5 1.4 2.5 2 0 0 2 2 2 2 Mediator complex subunit 2 Holin_BhlA PF10960.8 EFA81637.1 - 0.0016 18.3 0.8 0.0042 17.0 0.2 2.1 2 0 0 2 2 2 1 BhlA holin family EST1 PF10374.9 EFA81637.1 - 0.023 15.3 0.2 0.023 15.3 0.2 2.5 2 1 1 3 3 3 0 Telomerase activating protein Est1 Pyrophosphatase PF00719.19 EFA81637.1 - 0.078 12.8 0.4 0.84 9.4 0.1 2.1 2 0 0 2 2 2 0 Inorganic pyrophosphatase DASH_Dam1 PF08653.10 EFA81637.1 - 0.56 10.0 3.3 0.58 10.0 0.1 2.6 3 0 0 3 3 3 0 DASH complex subunit Dam1 bZIP_1 PF00170.21 EFA81637.1 - 0.74 10.0 5.6 2 8.6 0.2 3.3 4 0 0 4 4 4 0 bZIP transcription factor Muted PF14942.6 EFA81637.1 - 0.77 10.1 8.2 0.17 12.3 0.7 2.6 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein Arm-DNA-bind_5 PF17293.2 EFA81637.1 - 1.1 9.7 6.5 1.8 9.1 1.9 3.1 2 1 1 3 3 3 0 Arm DNA-binding domain PCRF PF03462.18 EFA81637.1 - 2.4 8.0 4.5 1.3 8.8 0.8 2.2 1 1 1 2 2 2 0 PCRF domain UPF0203 PF05254.12 EFA81638.1 - 1.9e-16 60.0 9.7 2.4e-16 59.7 9.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 EFA81638.1 - 0.0017 18.7 2.8 0.0041 17.4 2.8 1.5 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CX9C PF16860.5 EFA81638.1 - 0.0051 16.8 0.9 0.0051 16.8 0.9 2.6 2 1 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF4125 PF13526.6 EFA81638.1 - 0.0092 15.6 1.0 0.011 15.3 0.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4125) APC1_C PF18122.1 EFA81638.1 - 0.031 14.2 0.5 0.062 13.2 0.2 1.6 1 1 1 2 2 2 0 Anaphase-promoting complex sub unit 1 C-terminal domain Cmc1 PF08583.10 EFA81638.1 - 0.034 14.2 4.4 2.1 8.4 0.3 2.4 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like RINGv PF12906.7 EFA81638.1 - 0.073 13.2 2.6 0.17 12.0 2.6 1.8 1 1 0 1 1 1 0 RING-variant domain Ank_2 PF12796.7 EFA81639.1 - 2.5e-32 111.3 7.7 5.8e-07 30.0 0.1 5.1 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81639.1 - 1.6e-23 82.7 4.9 7.5e-05 23.2 0.0 7.9 4 2 5 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81639.1 - 2.3e-21 73.6 8.0 0.11 13.2 0.0 11.2 9 3 3 12 12 12 6 Ankyrin repeat Ank_5 PF13857.6 EFA81639.1 - 8.1e-20 70.6 6.3 0.00017 21.8 0.0 8.9 3 3 7 10 10 10 5 Ankyrin repeats (many copies) Ank PF00023.30 EFA81639.1 - 5.8e-08 32.8 4.4 8.6 7.0 0.3 7.9 4 3 1 5 5 5 2 Ankyrin repeat DUF5049 PF16468.5 EFA81639.1 - 0.008 16.1 0.1 30 4.6 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF5049) Ank_2 PF12796.7 EFA81640.1 - 2.3e-115 377.4 28.8 1.8e-19 70.1 0.1 8.0 3 1 5 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81640.1 - 8.4e-82 268.6 12.1 1.4e-12 47.8 0.0 11.5 3 2 7 11 11 11 11 Ankyrin repeats (many copies) Sec7 PF01369.20 EFA81640.1 - 4.3e-72 241.7 1.8 1.3e-71 240.1 1.8 1.8 1 0 0 1 1 1 1 Sec7 domain Ank_5 PF13857.6 EFA81640.1 - 1.3e-71 235.7 14.2 4.1e-11 42.9 0.0 12.2 1 1 13 14 14 14 14 Ankyrin repeats (many copies) Ank PF00023.30 EFA81640.1 - 1.6e-71 233.8 27.0 1.1e-05 25.6 0.0 15.9 16 0 0 16 16 16 13 Ankyrin repeat Ank_3 PF13606.6 EFA81640.1 - 3.8e-71 226.5 11.7 0.00012 22.3 0.0 15.5 15 0 0 15 15 15 14 Ankyrin repeat PH PF00169.29 EFA81640.1 - 5.7e-24 84.6 2.1 1.1e-23 83.7 0.3 2.5 2 0 0 2 2 2 1 PH domain zf-B_box PF00643.24 EFA81640.1 - 2.7e-08 33.8 5.0 7.2e-08 32.5 5.0 1.7 1 0 0 1 1 1 1 B-box zinc finger PH_11 PF15413.6 EFA81640.1 - 2.5e-05 24.6 0.3 2.5e-05 24.6 0.3 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EFA81640.1 - 0.027 14.7 0.0 0.93 9.8 0.0 3.6 4 0 0 4 4 4 0 Pleckstrin homology domain PH_6 PF15406.6 EFA81640.1 - 0.043 14.1 0.0 1.4 9.2 0.0 3.0 1 1 1 2 2 2 0 Pleckstrin homology domain Eapp_C PF10238.9 EFA81640.1 - 0.045 13.8 19.4 0.21 11.7 19.4 2.1 1 1 0 1 1 1 0 E2F-associated phosphoprotein IBR PF01485.21 EFA81640.1 - 0.068 13.4 3.6 0.21 11.8 3.6 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF2052 PF09747.9 EFA81640.1 - 0.38 10.9 25.2 0.017 15.2 17.9 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Mem_trans PF03547.18 EFA81640.1 - 0.49 8.7 2.7 0.82 8.0 2.7 1.4 1 0 0 1 1 1 0 Membrane transport protein CLN3 PF02487.17 EFA81640.1 - 1.4 7.8 3.6 3.4 6.6 3.6 1.6 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 EFA81640.1 - 2.4 7.8 6.6 5.9 6.6 6.6 1.7 1 0 0 1 1 1 0 Connexin Abhydrolase_1 PF00561.20 EFA81642.1 - 3.5e-13 49.8 0.3 2.4e-10 40.5 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA81642.1 - 2.8e-08 33.3 0.0 2e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydro_lipase PF04083.16 EFA81642.1 - 7.4e-08 31.9 0.0 2.2e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region FSH1 PF03959.13 EFA81642.1 - 0.011 15.4 0.1 0.13 11.9 0.1 2.0 2 0 0 2 2 2 0 Serine hydrolase (FSH1) UBX PF00789.20 EFA81643.1 - 3.1e-11 43.3 0.1 9e-11 41.8 0.0 1.7 2 0 0 2 2 2 1 UBX domain Kinesin_assoc PF16183.5 EFA81643.1 - 3.8 7.6 10.5 19 5.4 0.2 2.8 2 0 0 2 2 2 0 Kinesin-associated Macoilin PF09726.9 EFA81643.1 - 4.7 5.6 27.2 0.13 10.8 14.6 2.1 2 0 0 2 2 2 0 Macoilin family Methyltransf_25 PF13649.6 EFA81644.1 - 2.5e-06 28.1 0.0 6e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA81644.1 - 0.00045 20.1 0.0 0.0027 17.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA81644.1 - 0.00089 19.9 0.0 0.0024 18.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EFA81644.1 - 0.0016 17.9 0.0 0.0032 16.9 0.0 1.6 1 0 0 1 1 1 1 Tellurite resistance protein TehB Rhodanese PF00581.20 EFA81644.1 - 0.0052 17.3 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_31 PF13847.6 EFA81644.1 - 0.01 15.7 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF3825 PF12873.7 EFA81644.1 - 0.088 12.3 0.0 0.58 9.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3825) PrmA PF06325.13 EFA81644.1 - 0.1 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFA81644.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain adh_short_C2 PF13561.6 EFA81645.1 - 3.2e-64 216.7 0.2 4.1e-64 216.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFA81645.1 - 9.7e-54 181.8 0.8 1.2e-53 181.5 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFA81645.1 - 1.1e-10 41.7 0.4 2e-10 40.9 0.4 1.4 1 1 0 1 1 1 1 KR domain DUF5507 PF17612.2 EFA81645.1 - 0.004 16.9 0.7 0.0069 16.1 0.7 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF5507) AAA_31 PF13614.6 EFA81645.1 - 0.0045 16.9 0.3 0.011 15.7 0.2 1.6 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EFA81645.1 - 0.0066 16.5 0.2 0.014 15.4 0.2 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain THF_DHG_CYH_C PF02882.19 EFA81645.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 EFA81645.1 - 0.06 12.8 0.1 0.076 12.5 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 EFA81645.1 - 0.12 12.8 0.1 0.3 11.6 0.1 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding SLC35F PF06027.12 EFA81646.1 - 6.9e-101 337.7 31.4 6.9e-101 337.7 31.4 1.4 2 0 0 2 2 2 1 Solute carrier family 35 CRT-like PF08627.10 EFA81646.1 - 9.2e-10 38.0 16.5 9.2e-10 38.0 16.5 2.6 2 1 1 3 3 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EFA81646.1 - 4.1e-09 36.7 42.2 3.7e-07 30.4 16.1 2.7 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 EFA81646.1 - 5.7e-05 22.5 28.2 0.00015 21.1 28.2 1.6 1 1 0 1 1 1 1 UAA transporter family Mg_trans_NIPA PF05653.14 EFA81646.1 - 0.0032 16.6 19.7 0.012 14.7 5.7 2.8 2 1 0 3 3 3 2 Magnesium transporter NIPA DAD PF02109.16 EFA81646.1 - 0.015 15.6 1.7 0.052 13.9 1.7 2.0 1 0 0 1 1 1 0 DAD family EGF PF00008.27 EFA81646.1 - 0.026 14.8 3.0 0.026 14.8 3.0 2.0 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 EFA81646.1 - 0.055 13.6 5.6 0.11 12.7 5.6 1.4 1 0 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.13 EFA81646.1 - 0.14 12.6 7.8 0.32 11.4 7.8 1.6 1 0 0 1 1 1 0 EGF-like domain LRIF1 PF15741.5 EFA81646.1 - 0.28 9.7 4.6 0.37 9.3 4.6 1.1 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Pex24p PF06398.11 EFA81646.1 - 1.7 7.6 7.1 9 5.2 0.0 2.4 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin DUF5383 PF17355.2 EFA81646.1 - 1.7 9.0 0.0 1.7 9.0 0.0 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5383) YfhO PF09586.10 EFA81646.1 - 3.7 5.7 23.4 0.075 11.3 2.4 2.4 3 0 0 3 3 3 0 Bacterial membrane protein YfhO Chlam_PMP PF02415.17 EFA81647.1 - 0.0057 17.1 0.4 11 6.7 0.0 3.6 3 0 0 3 3 3 2 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat PCI PF01399.27 EFA81648.1 - 3e-13 50.2 0.6 3e-13 50.2 0.6 2.7 3 0 0 3 3 3 1 PCI domain eIF3m_C_helix PF18005.1 EFA81648.1 - 2.9e-10 39.7 1.8 2.9e-10 39.7 1.8 1.9 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix RraB PF06877.11 EFA81648.1 - 0.15 12.8 0.6 0.84 10.4 0.2 2.4 2 0 0 2 2 2 0 Regulator of ribonuclease activity B FNIP PF05725.12 EFA81649.1 - 6.1e-08 32.7 10.5 0.077 13.2 1.5 6.4 4 2 1 5 5 5 3 FNIP Repeat ubiquitin PF00240.23 EFA81649.1 - 1.2e-06 28.2 0.0 3e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family F-box_5 PF18511.1 EFA81649.1 - 0.00022 20.7 0.1 0.00056 19.4 0.1 1.6 1 0 0 1 1 1 1 F-box UBX PF00789.20 EFA81651.1 - 5e-14 52.3 0.3 4.8e-13 49.1 0.0 2.5 2 0 0 2 2 2 1 UBX domain MCD PF05292.11 EFA81651.1 - 1.8 8.1 12.0 4.9 6.6 2.5 2.5 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain GST_C_3 PF14497.6 EFA81652.1 - 1.6e-17 63.5 0.0 3.1e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA81652.1 - 8.3e-07 29.3 0.0 1.4e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA81652.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA81652.1 - 0.025 14.6 0.0 0.066 13.3 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DEAD PF00270.29 EFA81654.1 - 5.3e-14 52.4 0.0 2.2e-13 50.4 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81654.1 - 1.2e-11 44.9 0.1 1.2e-11 44.9 0.1 4.3 5 1 0 5 5 5 1 Helicase conserved C-terminal domain MarR PF01047.22 EFA81654.1 - 0.083 12.8 0.0 0.27 11.2 0.0 1.9 1 0 0 1 1 1 0 MarR family Tom22 PF04281.13 EFA81654.1 - 2.7 7.8 0.0 2.7 7.8 0.0 3.7 4 2 0 4 4 4 0 Mitochondrial import receptor subunit Tom22 Peptidase_M41 PF01434.18 EFA81655.1 - 1.6e-56 191.2 1.7 4.4e-56 189.8 1.7 1.8 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFA81655.1 - 5.8e-45 153.0 0.3 3.5e-42 144.0 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA81655.1 - 8.7e-08 31.8 0.0 1.9e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFA81655.1 - 2.5e-05 24.3 0.3 0.00037 20.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFA81655.1 - 9.8e-05 21.7 0.0 0.00022 20.6 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EFA81655.1 - 0.00013 22.3 0.0 0.018 15.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EFA81655.1 - 0.00029 21.0 0.0 0.002 18.3 0.0 2.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFA81655.1 - 0.00034 20.4 0.0 0.00099 18.9 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFA81655.1 - 0.00041 20.8 0.0 0.011 16.2 0.0 2.6 1 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EFA81655.1 - 0.00053 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EFA81655.1 - 0.0011 19.5 0.0 0.0011 19.5 0.0 3.9 4 1 0 4 4 3 1 AAA domain AAA_14 PF13173.6 EFA81655.1 - 0.0032 17.5 0.0 0.056 13.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EFA81655.1 - 0.0054 16.9 0.5 0.028 14.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFA81655.1 - 0.0054 16.1 0.1 0.015 14.7 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EFA81655.1 - 0.014 14.7 0.1 0.12 11.6 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 EFA81655.1 - 0.016 14.8 0.2 0.091 12.3 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFA81655.1 - 0.044 13.5 0.0 0.13 12.0 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF5496 PF17600.2 EFA81655.1 - 0.047 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5496) AAA_24 PF13479.6 EFA81655.1 - 0.05 13.3 0.7 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFA81655.1 - 0.058 13.6 0.0 0.058 13.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain HD_4 PF13328.6 EFA81655.1 - 0.077 12.7 0.4 0.17 11.6 0.1 1.7 2 0 0 2 2 1 0 HD domain AAA_25 PF13481.6 EFA81655.1 - 0.084 12.4 0.0 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA81655.1 - 0.29 11.6 0.0 0.29 11.6 0.0 3.9 3 1 0 3 3 2 0 ABC transporter AAA_17 PF13207.6 EFA81655.1 - 1 9.8 0.0 1 9.8 0.0 2.9 4 0 0 4 4 2 0 AAA domain Cytidylate_kin PF02224.18 EFA81655.1 - 1.7 8.3 5.9 35 4.0 0.0 3.3 3 0 0 3 3 3 0 Cytidylate kinase Peptidase_M8 PF01457.16 EFA81656.1 - 2.3e-36 125.6 0.1 4.8e-35 121.2 0.1 2.3 1 1 0 1 1 1 1 Leishmanolysin RhoGEF PF00621.20 EFA81657.1 - 1.3e-38 133.0 0.9 1.3e-38 133.0 0.9 2.1 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EFA81657.1 - 0.0025 18.3 0.2 0.0088 16.5 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EFA81657.1 - 0.0041 16.9 2.9 0.21 11.4 1.1 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_16 PF17838.1 EFA81657.1 - 0.012 15.5 0.2 0.025 14.4 0.2 1.5 1 0 0 1 1 1 0 PH domain Tubulin PF00091.25 EFA81658.1 - 1.1e-35 123.6 0.4 1.1e-35 123.6 0.4 3.0 2 1 1 3 3 3 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 EFA81658.1 - 9.8e-31 105.9 0.7 2.9e-30 104.4 0.7 1.9 1 0 0 1 1 1 1 FtsZ family, C-terminal domain NatB_MDM20 PF09797.9 EFA81659.1 - 1e-24 87.2 0.4 1e-24 87.2 0.4 2.3 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 EFA81659.1 - 2.2e-05 24.9 3.5 0.00089 19.7 0.7 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA81659.1 - 0.00025 20.7 2.0 0.037 13.8 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81659.1 - 0.0011 18.9 1.8 0.23 11.7 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA81659.1 - 0.0021 18.3 8.2 0.014 15.6 0.6 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFA81659.1 - 0.0039 17.3 1.6 0.34 11.3 0.7 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81659.1 - 0.0051 17.5 0.0 11 7.2 0.0 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA81659.1 - 0.016 15.2 0.9 1.3 9.2 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat Blo-t-5 PF11642.8 EFA81659.1 - 0.017 15.1 0.5 0.077 13.0 0.5 2.2 1 0 0 1 1 1 0 Mite allergen Blo t 5 NTF2 PF02136.20 EFA81659.1 - 0.018 15.6 1.5 0.61 10.7 0.1 3.3 3 0 0 3 3 3 0 Nuclear transport factor 2 (NTF2) domain TPR_12 PF13424.6 EFA81659.1 - 0.056 13.7 1.0 4.2 7.7 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA81659.1 - 0.071 13.8 3.1 13 6.7 0.3 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF3546 PF12066.8 EFA81659.1 - 0.47 10.7 4.8 0.5 10.6 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3546) PAP_central PF04928.17 EFA81659.1 - 4.4 6.2 6.5 2 7.3 0.2 2.6 2 1 0 2 2 2 0 Poly(A) polymerase central domain zf-CSL PF05207.13 EFA81660.1 - 4.2e-22 77.6 1.5 7.6e-22 76.8 1.5 1.4 1 0 0 1 1 1 1 CSL zinc finger zf-RING_7 PF02591.15 EFA81660.1 - 0.071 13.3 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 C4-type zinc ribbon domain FSA_C PF10479.9 EFA81660.1 - 2.9 5.9 6.2 3.6 5.6 6.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ribosomal_L35p PF01632.19 EFA81661.1 - 0.00019 21.9 0.7 0.00036 21.0 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L35 DUF287 PF03384.14 EFA81662.1 - 0.064 13.7 0.1 0.12 12.8 0.1 1.4 1 0 0 1 1 1 0 Drosophila protein of unknown function, DUF287 Turandot PF07240.11 EFA81662.1 - 0.15 12.0 0.9 8.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot EF-hand_6 PF13405.6 EFA81663.1 - 1.6e-18 64.9 7.9 0.00021 20.9 0.1 5.0 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 EFA81663.1 - 1.6e-17 63.7 8.7 1.8e-08 34.7 0.7 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFA81663.1 - 3.7e-17 60.5 9.8 8.8e-05 21.8 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFA81663.1 - 7.8e-09 35.3 7.9 0.00021 21.1 0.1 4.3 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA81663.1 - 1.1e-06 27.9 14.2 0.0022 17.4 0.2 4.7 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EFA81663.1 - 1.3e-05 25.5 2.6 0.0032 17.8 0.3 3.5 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFA81663.1 - 0.0086 16.0 3.3 0.13 12.2 0.0 2.9 1 1 3 4 4 4 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EFA81663.1 - 0.029 14.3 1.3 12 5.8 0.0 3.1 1 1 2 3 3 3 0 Caleosin related protein ABC2_membrane_3 PF12698.7 EFA81663.1 - 0.068 12.3 3.1 0.077 12.1 3.1 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein Ank_2 PF12796.7 EFA81664.1 - 6.7e-35 119.5 13.8 3.4e-06 27.6 1.6 8.5 3 1 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81664.1 - 2.3e-33 114.2 18.4 0.0011 19.5 0.0 12.7 10 3 4 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81664.1 - 2.5e-23 79.6 6.4 0.7 10.6 0.0 15.8 17 2 2 19 19 19 5 Ankyrin repeat Ank_5 PF13857.6 EFA81664.1 - 5.8e-19 67.9 12.9 0.026 14.9 0.5 13.3 7 5 10 17 17 17 7 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA81664.1 - 0.0035 17.2 0.0 8.5 6.4 0.0 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF5049) DUF3447 PF11929.8 EFA81664.1 - 0.022 14.7 10.0 3.9 7.5 0.1 5.3 5 1 1 6 6 6 0 Domain of unknown function (DUF3447) Ank PF00023.30 EFA81664.1 - 0.21 12.1 0.9 5e+02 1.4 0.1 5.7 5 1 0 5 5 5 0 Ankyrin repeat CBM49 PF09478.10 EFA81665.1 - 1.5e-16 60.4 0.4 2.7e-16 59.6 0.4 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 EFA81665.1 - 0.026 14.8 0.1 0.043 14.1 0.1 1.4 1 1 0 1 1 1 0 Cellulose binding domain Pur_ac_phosph_N PF16656.5 EFA81665.1 - 0.034 14.7 0.3 0.064 13.8 0.3 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Zip PF02535.22 EFA81666.1 - 7.3e-31 107.6 26.0 2.6e-29 102.5 26.0 2.7 1 1 0 1 1 1 1 ZIP Zinc transporter SR-25 PF10500.9 EFA81666.1 - 0.00043 20.0 13.6 0.00043 20.0 13.6 1.8 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein TamB PF04357.13 EFA81666.1 - 0.00088 18.6 0.4 0.00088 18.6 0.4 1.4 2 0 0 2 2 2 1 TamB, inner membrane protein subunit of TAM complex DUF3446 PF11928.8 EFA81666.1 - 0.024 14.9 6.7 0.024 14.9 6.7 2.1 2 0 0 2 2 2 0 Early growth response N-terminal domain ESSS PF10183.9 EFA81666.1 - 0.11 12.7 0.6 0.21 11.8 0.6 1.4 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Myc_N PF01056.18 EFA81666.1 - 0.84 9.5 11.4 0.64 9.9 6.9 2.0 2 0 0 2 2 2 0 Myc amino-terminal region DUF2796 PF10986.8 EFA81666.1 - 1.3 8.9 12.5 5.7 6.9 8.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) Shisa PF13908.6 EFA81666.1 - 6.3 7.0 8.0 1.2 9.4 1.8 2.6 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator Cation_efflux PF01545.21 EFA81667.1 - 3.2e-31 108.6 12.8 3.9e-24 85.5 2.0 2.3 1 1 1 2 2 2 2 Cation efflux family NAP PF00956.18 EFA81668.1 - 2.3e-48 164.7 1.9 4.3e-48 163.8 1.9 1.5 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Homeodomain PF00046.29 EFA81668.1 - 2.6e-05 24.0 0.1 0.00013 21.7 0.1 2.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EFA81668.1 - 0.00091 19.1 0.0 0.0024 17.7 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain BRCA2 PF00634.18 EFA81668.1 - 0.13 12.0 0.2 0.34 10.6 0.2 1.8 1 0 0 1 1 1 0 BRCA2 repeat PHM7_cyt PF14703.6 EFA81668.1 - 0.15 12.2 1.1 1 9.5 0.0 2.7 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter CdvA PF18822.1 EFA81668.1 - 0.42 10.4 2.5 13 5.6 0.7 2.8 2 1 0 2 2 2 0 CdvA-like coiled-coil domain PBP1_TM PF14812.6 EFA81668.1 - 3.4 8.1 11.3 0.22 11.9 3.2 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YfhD PF14151.6 EFA81668.1 - 3.5 7.9 5.8 40 4.5 0.0 2.7 2 0 0 2 2 2 0 YfhD-like protein Mucin PF01456.17 EFA81669.1 - 6.2 6.8 20.2 1 9.4 15.4 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein Pkinase PF00069.25 EFA81670.1 - 1.2e-73 247.8 0.0 1.4e-73 247.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81670.1 - 1.1e-28 100.2 0.0 1.6e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA81670.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DnaJ PF00226.31 EFA81671.1 - 1.1e-23 83.1 1.3 1.1e-23 83.1 1.3 3.7 4 0 0 4 4 4 1 DnaJ domain zf-C2H2_jaz PF12171.8 EFA81671.1 - 3e-08 33.7 13.4 1.9e-07 31.2 2.4 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFA81671.1 - 2.5e-05 24.5 13.7 0.024 15.0 0.2 3.5 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EFA81671.1 - 5.5e-05 23.7 6.6 0.14 13.1 0.6 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger DUF2256 PF10013.9 EFA81671.1 - 0.002 18.2 0.6 0.16 12.1 0.0 2.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2 PF00096.26 EFA81671.1 - 0.0022 18.3 10.7 0.12 12.9 1.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type Actino_peptide PF14408.6 EFA81671.1 - 0.053 13.6 1.2 0.17 12.0 1.2 1.9 1 0 0 1 1 1 0 Ribosomally synthesised peptide in actinomycetes zf-met PF12874.7 EFA81671.1 - 0.95 9.9 7.8 0.06 13.8 1.8 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type C1_4 PF07975.12 EFA81671.1 - 1.4 9.2 4.4 3.6 7.9 0.8 2.8 2 0 0 2 2 2 0 TFIIH C1-like domain zf-UBR PF02207.20 EFA81672.1 - 1.6e-17 63.4 8.5 1.6e-17 63.4 8.5 3.2 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) REPA_OB_2 PF16900.5 EFA81672.1 - 7.1e-06 25.9 0.0 2.5e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EFA81672.1 - 0.00023 21.1 0.1 0.00081 19.3 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain DUF3885 PF13021.6 EFA81672.1 - 0.23 11.6 1.2 3.2 7.9 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) NSP2-B_epitope PF14757.6 EFA81672.1 - 0.26 10.9 2.1 0.55 9.9 2.1 1.4 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein Ras PF00071.22 EFA81673.1 - 4e-50 169.6 0.1 4.5e-50 169.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA81673.1 - 2.3e-29 102.1 0.1 4e-29 101.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA81673.1 - 1e-20 73.9 0.0 1.2e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA81673.1 - 1.7e-08 34.1 0.1 2.3e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA81673.1 - 1.2e-05 25.4 0.0 2.5e-05 24.3 0.0 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA81673.1 - 4.8e-05 23.0 0.1 0.00074 19.1 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFA81673.1 - 0.0021 17.5 0.0 0.0048 16.3 0.0 1.5 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EFA81673.1 - 0.0045 16.7 0.4 0.016 14.9 0.2 1.9 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFA81673.1 - 0.013 15.6 0.1 0.043 13.9 0.0 1.8 1 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFA81673.1 - 0.051 13.6 0.0 0.096 12.7 0.0 1.4 1 1 0 1 1 1 0 Dynamin family G-alpha PF00503.20 EFA81673.1 - 0.061 12.5 1.9 6 5.9 0.1 2.9 2 1 1 3 3 3 0 G-protein alpha subunit AAA_22 PF13401.6 EFA81673.1 - 0.07 13.4 0.0 0.12 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFA81673.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Thioredoxin PF00085.20 EFA81674.1 - 7.2e-27 93.4 0.1 8.5e-27 93.2 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFA81674.1 - 3.4e-10 40.3 0.2 1.5e-08 35.0 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EFA81674.1 - 7.4e-05 22.5 0.0 8.5e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFA81674.1 - 0.00012 22.3 0.0 0.005 17.1 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like DIM1 PF02966.16 EFA81674.1 - 0.0027 17.5 0.0 0.0043 16.8 0.0 1.4 1 1 0 1 1 1 1 Mitosis protein DIM1 HyaE PF07449.11 EFA81674.1 - 0.0028 17.6 0.0 0.0053 16.7 0.0 1.6 1 1 0 1 1 1 1 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 EFA81674.1 - 0.004 17.1 0.0 0.0049 16.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_3 PF13192.6 EFA81674.1 - 0.017 15.1 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_7 PF13899.6 EFA81674.1 - 0.019 15.1 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like NADH_4Fe-4S PF10589.9 EFA81674.1 - 0.046 13.8 0.0 0.096 12.8 0.0 1.5 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Redoxin PF08534.10 EFA81674.1 - 0.084 12.6 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Redoxin OST3_OST6 PF04756.13 EFA81674.1 - 0.085 12.2 0.0 0.098 12.0 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 EFA81674.1 - 0.15 12.3 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin TraF PF13728.6 EFA81674.1 - 0.17 11.7 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Exo_endo_phos PF03372.23 EFA81675.1 - 3.4e-09 36.5 0.0 0.00039 20.0 0.0 2.2 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family UQ_con PF00179.26 EFA81677.1 - 8.1e-38 129.2 0.1 1.9e-37 128.0 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme YL1 PF05764.13 EFA81677.1 - 0.0004 20.6 17.9 0.0006 20.0 17.9 1.3 1 0 0 1 1 1 1 YL1 nuclear protein SDA1 PF05285.12 EFA81677.1 - 0.019 14.4 26.7 0.026 14.0 26.7 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFA81677.1 - 0.032 12.5 19.4 0.042 12.1 19.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SOG2 PF10428.9 EFA81677.1 - 0.062 12.5 15.5 0.086 12.0 15.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Prok-E2_B PF14461.6 EFA81677.1 - 0.13 11.9 1.4 0.15 11.7 0.0 1.9 2 1 0 2 2 2 0 Prokaryotic E2 family B TFIIF_alpha PF05793.12 EFA81677.1 - 1.2 7.6 33.1 1.4 7.4 33.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2547 PF10818.8 EFA81677.1 - 2.6 9.0 0.0 2.6 9.0 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2547) UQ_con PF00179.26 EFA81678.1 - 0.044 13.4 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme P16-Arc PF04699.14 EFA81679.1 - 1.5e-36 126.1 0.1 1.6e-36 126.0 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 EFA81679.1 - 0.0048 17.2 0.0 0.0073 16.6 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ArsD PF06953.11 EFA81679.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD Nop10p PF04135.12 EFA81681.1 - 4.8e-16 58.5 0.3 7.1e-16 58.0 0.3 1.2 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family CBS PF00571.28 EFA81682.1 - 5.4e-07 30.0 3.9 0.18 12.3 0.0 3.4 3 0 0 3 3 3 3 CBS domain Ribosomal_L29 PF00831.23 EFA81683.1 - 1.8e-14 53.4 3.4 1.8e-14 53.4 3.4 2.0 2 0 0 2 2 2 1 Ribosomal L29 protein DUF2508 PF10704.9 EFA81683.1 - 0.045 13.9 1.7 0.045 13.9 1.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Snapin_Pallidin PF14712.6 EFA81683.1 - 0.1 13.0 5.9 0.18 12.2 2.3 2.1 1 1 1 2 2 2 0 Snapin/Pallidin Ins_P5_2-kin PF06090.12 EFA81684.1 - 2e-94 316.8 0.6 2.5e-94 316.4 0.6 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF2369 PF10179.9 EFA81684.1 - 0.053 13.9 0.4 0.25 11.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) CCDC-167 PF15188.6 EFA81684.1 - 0.1 13.0 1.5 0.34 11.3 1.5 1.9 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DCP1 PF06058.13 EFA81684.1 - 0.29 11.1 3.6 0.24 11.3 1.2 2.0 2 0 0 2 2 2 0 Dcp1-like decapping family Kinesin PF00225.23 EFA81685.1 - 3.9e-108 361.3 0.4 3.9e-108 361.3 0.4 3.0 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFA81685.1 - 6.1e-28 97.6 3.4 1.3e-27 96.6 0.1 3.4 3 0 0 3 3 3 1 Microtubule binding PHAT PF09246.10 EFA81685.1 - 0.01 15.6 0.1 0.041 13.7 0.1 2.1 1 0 0 1 1 1 0 PHAT AAA_22 PF13401.6 EFA81685.1 - 0.089 13.1 0.7 0.87 9.9 0.0 3.0 2 1 1 3 3 3 0 AAA domain Ac76 PF05814.11 EFA81685.1 - 0.28 11.2 3.5 1.6 8.8 0.4 3.1 2 0 0 2 2 2 0 Orf76 (Ac76) MetOD2 PF18548.1 EFA81685.1 - 6.3 7.0 11.4 22 5.2 2.6 4.3 2 2 0 2 2 2 0 Metanogen output domain 2 GPP34 PF05719.11 EFA81686.1 - 1.6e-10 41.4 0.0 1.8e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) DUF1943 PF09172.11 EFA81686.1 - 0.0062 15.8 0.0 0.009 15.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) GLTT PF01744.20 EFA81686.1 - 0.49 10.2 2.1 0.34 10.7 0.3 1.6 2 0 0 2 2 2 0 GLTT repeat (6 copies) WD40 PF00400.32 EFA81688.1 - 2e-15 56.9 1.7 0.00031 21.5 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat F-box-like PF12937.7 EFA81688.1 - 6.3e-11 42.0 0.0 1.4e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA81688.1 - 1.1e-08 34.7 0.1 3.5e-08 33.1 0.1 1.9 1 0 0 1 1 1 1 F-box domain START PF01852.19 EFA81688.1 - 1.1e-05 25.0 0.0 3.6e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 START domain F-box_4 PF15966.5 EFA81688.1 - 0.029 14.3 0.0 0.11 12.4 0.0 2.0 1 0 0 1 1 1 0 F-box DUF4829 PF16111.5 EFA81688.1 - 3.7 8.4 12.9 2.9 8.7 9.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4829) Ima1_N PF09779.9 EFA81689.1 - 8.2e-23 81.8 12.6 8.2e-23 81.8 12.6 2.5 3 1 0 3 3 3 1 Ima1 N-terminal domain DUF2719 PF10891.8 EFA81689.1 - 0.00079 19.3 0.4 0.071 13.0 0.2 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2719) zinc-ribbon_6 PF10005.9 EFA81689.1 - 3.8 8.2 7.3 1.3 9.8 0.9 2.4 1 1 1 2 2 2 0 zinc-ribbon domain Cas_CXXC_CXXC PF09706.10 EFA81689.1 - 4.1 7.7 11.4 0.8 10.0 1.6 3.5 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_CXXC_CXXC) CAP PF00188.26 EFA81691.1 - 8.9e-16 58.9 0.0 1.1e-15 58.6 0.0 1.0 1 0 0 1 1 1 1 Cysteine-rich secretory protein family NTF2 PF02136.20 EFA81691.1 - 0.13 12.8 0.0 0.16 12.5 0.0 1.2 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain XPC-binding PF09280.11 EFA81692.1 - 5.8e-21 74.0 8.9 8.5e-21 73.4 8.9 1.3 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 EFA81692.1 - 8.7e-06 25.5 0.2 1.8e-05 24.5 0.2 1.6 1 0 0 1 1 1 1 UBA/TS-N domain MCM_N PF14551.6 EFA81692.1 - 0.011 16.3 0.1 0.017 15.7 0.1 1.5 1 1 0 1 1 1 0 MCM N-terminal domain GlnE PF03710.15 EFA81692.1 - 0.022 14.2 0.2 0.027 13.9 0.2 1.1 1 0 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase ubiquitin PF00240.23 EFA81693.1 - 1.1e-16 60.3 0.2 1.7e-16 59.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EFA81693.1 - 6.7e-13 48.2 1.1 1.9e-12 46.8 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain CUE PF02845.16 EFA81693.1 - 0.0011 18.7 0.1 0.0035 17.0 0.0 1.9 2 0 0 2 2 2 1 CUE domain Rad60-SLD PF11976.8 EFA81693.1 - 0.0011 18.8 0.3 0.0011 18.8 0.3 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Hamartin PF04388.12 EFA81693.1 - 0.032 12.9 6.4 0.03 13.0 6.4 1.1 1 0 0 1 1 1 0 Hamartin protein Ubiquitin_5 PF18037.1 EFA81693.1 - 0.037 14.4 0.2 0.064 13.6 0.2 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA81693.1 - 0.059 13.5 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Med13_C PF06333.12 EFA81693.1 - 0.061 12.6 7.5 0.065 12.5 7.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain UBA_2 PF08587.11 EFA81693.1 - 0.079 13.1 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) UBA_3 PF09288.10 EFA81693.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Med3 PF11593.8 EFA81693.1 - 0.58 9.3 16.3 0.85 8.7 16.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PRCC PF10253.9 EFA81693.1 - 0.7 10.6 6.7 1 10.1 6.7 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF3123 PF11321.8 EFA81693.1 - 3 8.5 13.4 0.17 12.6 4.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3123) Pex14_N PF04695.13 EFA81693.1 - 9.9 6.8 15.6 55 4.4 12.5 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Thioredoxin PF00085.20 EFA81694.1 - 9.3e-11 41.6 0.0 1.6e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Cornichon PF03311.14 EFA81694.1 - 0.00024 21.4 0.1 0.00024 21.4 0.1 2.4 1 1 1 2 2 2 1 Cornichon protein EF_TS PF00889.19 EFA81695.1 - 3.8e-37 127.9 0.0 8.6e-35 120.2 0.0 2.3 1 1 0 1 1 1 1 Elongation factor TS ABC_sub_bind PF04392.12 EFA81695.1 - 0.0033 16.7 0.1 0.0058 15.9 0.1 1.3 1 0 0 1 1 1 1 ABC transporter substrate binding protein AvrM-A PF18241.1 EFA81695.1 - 0.0067 16.8 1.9 0.026 14.9 0.2 2.1 2 0 0 2 2 2 1 Flax-rust effector AvrM-A UBA PF00627.31 EFA81695.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain HBS1_N PF08938.10 EFA81695.1 - 0.024 14.9 0.2 0.12 12.7 0.0 2.1 2 0 0 2 2 2 0 HBS1 N-terminus TPR_12 PF13424.6 EFA81696.1 - 5.2e-28 97.1 3.2 1e-07 32.2 0.0 5.2 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 EFA81696.1 - 1.8e-09 37.1 1.5 2.3 8.2 0.2 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA81696.1 - 9.9e-06 25.1 4.0 0.0025 17.3 1.1 2.7 3 0 0 3 3 3 2 MalT-like TPR region TPR_19 PF14559.6 EFA81696.1 - 1.5e-05 25.4 3.4 0.76 10.3 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA81696.1 - 0.0009 19.0 2.5 5.7 6.9 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA81696.1 - 0.00094 19.8 0.9 6.8 7.8 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA81696.1 - 0.0056 16.6 2.3 2.7 8.2 0.0 4.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81696.1 - 0.0099 15.9 5.5 3.4 8.0 0.0 5.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA81696.1 - 0.015 15.5 9.4 0.9 9.9 0.4 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA81696.1 - 0.057 13.8 5.3 0.29 11.6 0.4 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat SIT PF15330.6 EFA81696.1 - 1.1 9.7 5.4 3.3 8.2 1.2 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT RRM_1 PF00076.22 EFA81697.1 - 2.3e-30 104.2 0.1 3.4e-17 62.0 0.0 4.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA81697.1 - 1.4e-06 28.1 0.0 0.042 13.7 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EFA81697.1 - 4.8e-05 23.4 0.0 0.21 11.7 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif Spo7_2_N PF15407.6 EFA81697.1 - 0.037 13.7 0.0 3.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Sporulation protein family 7 Smg4_UPF3 PF03467.15 EFA81697.1 - 0.048 13.7 2.3 0.83 9.6 0.0 3.1 3 0 0 3 3 3 0 Smg-4/UPF3 family Band_3_cyto PF07565.13 EFA81697.1 - 1.1 9.1 4.9 2.5 7.8 4.9 1.6 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FGE-sulfatase PF03781.16 EFA81698.1 - 0.021 14.4 3.7 0.043 13.4 3.7 1.5 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 ALAD PF00490.21 EFA81698.1 - 0.19 10.9 2.1 0.27 10.4 2.1 1.2 1 0 0 1 1 1 0 Delta-aminolevulinic acid dehydratase GIDA_assoc PF13932.6 EFA81698.1 - 0.4 10.9 9.0 0.64 10.2 9.0 1.3 1 0 0 1 1 1 0 GidA associated domain Exonuc_VII_L PF02601.15 EFA81698.1 - 0.8 9.2 13.5 1.1 8.8 13.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Glyco_transf_41 PF13844.6 EFA81698.1 - 6.1 5.1 13.3 8.5 4.7 13.3 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 41 Zip PF02535.22 EFA81699.1 - 0.024 13.9 2.3 0.024 13.9 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RRN3 PF05327.11 EFA81699.1 - 0.062 11.8 2.9 0.067 11.7 2.9 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 dsRBD2 PF17842.1 EFA81699.1 - 0.12 12.6 4.7 0.16 12.1 4.7 1.2 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Tim54 PF11711.8 EFA81699.1 - 0.14 10.9 4.8 0.16 10.7 4.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5580 PF17743.1 EFA81699.1 - 0.14 10.7 6.3 0.16 10.4 6.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) FAM176 PF14851.6 EFA81699.1 - 1.2 8.8 4.8 1.9 8.1 4.8 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EFA81699.1 - 2 6.6 7.9 2.3 6.4 7.9 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 EFA81699.1 - 2.2 7.0 9.4 2.6 6.7 9.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ceramidase_alk PF04734.13 EFA81700.1 - 3.3e-222 738.6 0.0 3.9e-222 738.4 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EFA81700.1 - 1.1e-46 158.8 0.2 2.1e-46 157.9 0.2 1.5 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal CBM49 PF09478.10 EFA81701.1 - 2.3e-17 63.0 0.6 3.2e-17 62.6 0.6 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 EFA81701.1 - 0.049 14.0 0.6 0.13 12.6 0.5 1.7 1 1 1 2 2 2 0 Cellulose binding domain DUF5335 PF17269.2 EFA81702.1 - 0.096 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5335) RNA_lig_T4_1 PF09511.10 EFA81703.1 - 2.3e-38 132.3 0.1 3.1e-38 131.8 0.1 1.2 1 0 0 1 1 1 1 RNA ligase HmuY PF14064.6 EFA81703.1 - 0.13 12.4 0.0 3 8.1 0.0 2.3 1 1 0 1 1 1 0 HmuY protein VHP PF02209.19 EFA81704.1 - 9.2e-15 54.4 0.9 9.2e-15 54.4 0.9 3.0 3 0 0 3 3 3 1 Villin headpiece domain CLTH PF10607.9 EFA81705.1 - 2.3e-37 128.1 2.4 3.1e-37 127.7 2.4 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EFA81705.1 - 2.9e-10 39.7 0.7 6.5e-10 38.6 0.2 1.9 2 0 0 2 2 2 1 LisH SR-25 PF10500.9 EFA81705.1 - 0.39 10.3 8.2 0.68 9.5 8.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CRCB PF02537.15 EFA81706.1 - 2.7e-17 62.9 5.9 3.4e-17 62.5 5.9 1.1 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) GtrA PF04138.14 EFA81706.1 - 0.011 16.0 7.2 0.26 11.5 0.7 2.1 1 1 1 2 2 2 0 GtrA-like protein DUF1761 PF08570.10 EFA81706.1 - 0.032 14.5 3.2 0.074 13.3 3.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1761) RRN3 PF05327.11 EFA81706.1 - 0.035 12.7 1.9 0.044 12.3 1.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF456 PF04306.13 EFA81706.1 - 0.037 14.3 4.7 0.072 13.4 4.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF456) FAM176 PF14851.6 EFA81706.1 - 0.16 11.6 6.4 7.5 6.2 0.0 2.2 2 0 0 2 2 2 0 FAM176 family ABC2_membrane_5 PF13346.6 EFA81706.1 - 1 8.9 11.4 1.2 8.6 11.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein MIP PF00230.20 EFA81707.1 - 1.8e-48 165.3 14.1 9.8e-33 113.8 6.2 2.0 2 0 0 2 2 2 2 Major intrinsic protein PalH PF08733.10 EFA81707.1 - 0.019 14.0 0.3 0.031 13.3 0.3 1.3 1 0 0 1 1 1 0 PalH/RIM21 DUF2721 PF11026.8 EFA81707.1 - 0.1 12.5 0.0 0.1 12.5 0.0 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) Oxidored_q3 PF00499.20 EFA81707.1 - 0.48 10.1 9.5 0.73 9.5 6.0 2.5 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Patatin PF01734.22 EFA81708.1 - 3.2e-17 63.4 1.7 6.3e-17 62.4 1.7 1.5 1 1 0 1 1 1 1 Patatin-like phospholipase CBM49 PF09478.10 EFA81709.1 - 2.7e-17 62.8 0.4 3.7e-17 62.4 0.4 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 EFA81709.1 - 0.047 14.0 0.4 0.12 12.6 0.4 1.7 1 1 1 2 2 2 0 Cellulose binding domain Voltage_CLC PF00654.20 EFA81710.1 - 1.1e-109 366.9 20.4 1.1e-109 366.9 20.4 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EFA81710.1 - 2.5e-20 72.7 0.1 3.8e-09 36.8 0.0 2.8 2 0 0 2 2 2 2 CBS domain B277 PF17623.2 EFA81710.1 - 0.067 12.3 0.4 0.41 9.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function WAP PF00095.21 EFA81711.1 - 0.072 13.5 13.7 0.16 12.4 13.7 1.6 1 1 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' MatE PF01554.18 EFA81712.1 - 5.6e-61 204.9 33.7 5.7e-34 117.1 8.2 2.6 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 EFA81712.1 - 0.00025 21.1 11.0 0.00025 21.1 11.0 4.2 3 2 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain DUF1419 PF07215.11 EFA81712.1 - 0.015 15.4 0.1 0.033 14.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1419) WSS_VP PF12175.8 EFA81712.1 - 1.8 8.0 4.9 0.42 10.1 0.8 2.0 2 1 1 3 3 3 0 White spot syndrome virus structural envelope protein VP HATPase_c PF02518.26 EFA81713.1 - 1.8e-30 105.7 0.3 3.8e-30 104.7 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA81713.1 - 2.3e-23 82.5 0.0 5.5e-22 78.0 0.0 2.9 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 EFA81713.1 - 2.7e-14 52.9 0.0 7.2e-14 51.6 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EFA81713.1 - 0.00032 20.7 0.0 0.001 19.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain Tox-SHH PF15652.6 EFA81713.1 - 0.031 15.2 1.6 0.15 13.0 1.6 2.2 1 0 0 1 1 1 0 HNH/Endo VII superfamily toxin with a SHH signature TFB6 PF17110.5 EFA81713.1 - 0.56 9.9 4.2 1.9 8.2 0.0 2.8 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Longin PF13774.6 EFA81715.1 - 8.6e-23 80.2 1.1 1.5e-22 79.4 1.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EFA81715.1 - 1.3e-15 56.9 0.1 2.4e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Synaptobrevin Methyltransf_10 PF05971.12 EFA81716.1 - 3.4e-67 226.9 1.3 8.7e-66 222.3 1.3 2.7 1 1 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EFA81716.1 - 1.5e-10 40.9 0.0 3.4e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFA81716.1 - 2.2e-06 27.3 0.0 4.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFA81716.1 - 0.00092 19.0 0.0 0.0036 17.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 EFA81716.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.7 EFA81716.1 - 0.058 13.3 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EFA81716.1 - 0.11 13.2 0.0 0.25 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFA81716.1 - 2.6 8.8 0.0 2.6 8.8 0.0 3.5 3 0 0 3 3 3 0 Methyltransferase domain HA2 PF04408.23 EFA81717.1 - 1e-27 96.6 0.0 1e-27 96.6 0.0 5.7 5 3 0 5 5 5 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA81717.1 - 1.6e-17 63.6 0.1 4.9e-17 62.1 0.1 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFA81717.1 - 2.5e-09 37.5 4.1 2.8e-08 34.1 0.0 3.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA81717.1 - 1.5e-06 28.1 2.5 1.9e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA81717.1 - 0.0004 20.7 1.4 0.0035 17.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain YL1 PF05764.13 EFA81717.1 - 0.017 15.2 1.2 0.017 15.2 1.2 6.3 4 2 1 5 5 5 0 YL1 nuclear protein G0-G1_switch_2 PF15103.6 EFA81717.1 - 0.02 15.3 0.0 0.02 15.3 0.0 5.7 5 1 1 6 6 6 0 G0/G1 switch protein 2 DUF3439 PF11921.8 EFA81717.1 - 0.24 11.4 8.3 0.77 9.7 8.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AAA_23 PF13476.6 EFA81717.1 - 0.36 11.3 0.0 0.36 11.3 0.0 6.7 4 1 0 5 5 5 0 AAA domain Ras PF00071.22 EFA81718.1 - 5.7e-57 191.8 1.3 7.4e-57 191.5 1.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA81718.1 - 1.3e-35 122.2 0.3 2.5e-35 121.3 0.3 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA81718.1 - 3.8e-21 75.3 0.5 4.6e-21 75.0 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA81718.1 - 9e-08 31.7 0.4 1.1e-07 31.5 0.4 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFA81718.1 - 7.9e-06 25.4 2.7 5e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFA81718.1 - 2.2e-05 24.1 0.4 0.0055 16.3 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA81718.1 - 0.00064 19.8 0.2 0.002 18.2 0.2 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EFA81718.1 - 0.0012 18.3 0.0 0.0024 17.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA PF00004.29 EFA81718.1 - 0.0024 18.3 0.0 0.0087 16.5 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFA81718.1 - 0.0062 16.5 0.2 3.9 7.4 0.0 2.5 1 1 1 3 3 3 2 RsgA GTPase AAA_24 PF13479.6 EFA81718.1 - 0.0063 16.3 0.1 0.012 15.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFA81718.1 - 0.0068 15.9 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region G-alpha PF00503.20 EFA81718.1 - 0.007 15.6 0.6 0.22 10.7 0.0 2.6 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.9 EFA81718.1 - 0.017 14.8 0.2 0.2 11.4 0.2 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation YwhD PF08741.10 EFA81718.1 - 0.033 13.9 0.1 0.059 13.1 0.1 1.4 1 0 0 1 1 1 0 YwhD family AAA_16 PF13191.6 EFA81718.1 - 0.077 13.4 0.0 0.14 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain CD36 PF01130.21 EFA81719.1 - 2.7e-61 207.5 14.4 4.9e-42 144.0 1.7 2.3 2 0 0 2 2 2 2 CD36 family RasGAP PF00616.19 EFA81719.1 - 8.5e-50 169.4 6.2 2.9e-49 167.6 4.1 2.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFA81719.1 - 1.8e-19 70.3 7.6 1.8e-19 70.3 7.6 2.3 2 0 0 2 2 2 1 RasGAP C-terminus MCM_N PF14551.6 EFA81719.1 - 0.065 13.8 0.4 0.29 11.7 0.4 2.1 1 0 0 1 1 1 0 MCM N-terminal domain TPR_1 PF00515.28 EFA81720.1 - 4e-14 51.7 11.1 3e-06 26.8 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA81720.1 - 6.2e-14 50.9 8.0 0.00017 21.4 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA81720.1 - 8.4e-08 31.8 4.9 0.00055 19.9 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat zf-C3HC4 PF00097.25 EFA81720.1 - 7.4e-06 25.7 19.5 2.2e-05 24.2 19.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 EFA81720.1 - 1.1e-05 25.6 5.4 0.0015 18.8 1.6 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA81720.1 - 1.3e-05 25.2 5.6 0.0023 18.2 0.4 4.0 3 2 0 3 3 2 2 Tetratricopeptide repeat zf-C3HC4_2 PF13923.6 EFA81720.1 - 1.6e-05 24.6 19.8 3.9e-05 23.4 19.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) NARP1 PF12569.8 EFA81720.1 - 4.5e-05 22.6 0.3 4.5e-05 22.6 0.3 1.8 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 zf-RING_5 PF14634.6 EFA81720.1 - 8.2e-05 22.5 18.6 0.00026 20.9 18.6 1.9 1 0 0 1 1 1 1 zinc-RING finger domain TPR_19 PF14559.6 EFA81720.1 - 0.00011 22.6 0.2 0.0017 18.8 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat zf-C3HC4_3 PF13920.6 EFA81720.1 - 0.00015 21.6 14.8 0.00015 21.6 14.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) ANAPC3 PF12895.7 EFA81720.1 - 0.00067 19.8 4.8 0.0016 18.6 3.9 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFA81720.1 - 0.00076 19.1 7.3 0.1 12.3 1.9 3.5 1 1 2 3 3 3 1 TPR repeat zf-RING_2 PF13639.6 EFA81720.1 - 0.0012 19.1 19.0 0.0033 17.7 19.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA81720.1 - 0.0023 17.9 16.9 0.0059 16.6 15.6 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFA81720.1 - 0.1 12.8 20.5 0.31 11.2 20.5 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Menin PF05053.13 EFA81720.1 - 0.13 10.6 16.0 0.2 10.0 16.0 1.3 1 0 0 1 1 1 0 Menin zf-RING_6 PF14835.6 EFA81720.1 - 0.2 11.5 10.4 0.39 10.6 10.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Lin-8 PF03353.15 EFA81720.1 - 0.75 9.3 28.2 0.39 10.2 4.7 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist TPR_6 PF13174.6 EFA81720.1 - 0.85 10.4 5.4 14 6.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Prok-RING_4 PF14447.6 EFA81720.1 - 1.3 8.9 20.2 61 3.6 0.5 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Zn-C2H2_12 PF18112.1 EFA81720.1 - 2.1 8.9 10.3 6.3 7.4 2.4 3.1 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain SR-25 PF10500.9 EFA81720.1 - 5 6.7 25.3 0.21 11.2 19.8 1.5 2 0 0 2 2 1 0 Nuclear RNA-splicing-associated protein RasGAP PF00616.19 EFA81721.1 - 2.6e-12 46.9 0.9 2.8e-08 33.7 0.0 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase Curto_V3 PF07436.11 EFA81722.1 - 0.056 13.8 0.8 0.21 12.0 0.3 1.9 2 0 0 2 2 2 0 Curtovirus V3 protein IL1_propep PF02394.16 EFA81722.1 - 0.085 13.8 2.0 0.29 12.1 0.1 2.0 2 0 0 2 2 2 0 Interleukin-1 propeptide CH PF00307.31 EFA81723.1 - 8.5e-41 138.5 16.9 2.1e-17 63.3 0.3 6.0 6 0 0 6 6 6 3 Calponin homology (CH) domain CH_2 PF06294.11 EFA81723.1 - 2.2e-05 24.5 0.0 0.002 18.2 0.0 4.0 2 0 0 2 2 2 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFA81723.1 - 8.2e-05 22.4 2.6 0.00029 20.6 0.1 3.1 3 0 0 3 3 3 1 CAMSAP CH domain Gp_dh_C PF02800.20 EFA81723.1 - 0.11 12.0 2.7 0.46 10.1 0.2 2.9 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain MtrB PF05440.12 EFA81723.1 - 5.7 7.4 5.3 3.9 8.0 0.4 3.4 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B zf-RING_UBOX PF13445.6 EFA81724.1 - 2.3e-09 37.1 8.3 2.3e-09 37.1 8.3 3.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA81724.1 - 3.7e-09 36.3 10.5 3.7e-09 36.3 10.5 3.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA81724.1 - 4.1e-08 32.9 10.5 4.1e-08 32.9 10.5 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFA81724.1 - 4.8e-07 29.8 12.0 4.8e-07 29.8 12.0 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFA81724.1 - 8.5e-07 28.8 12.4 8.5e-07 28.8 12.4 3.2 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA81724.1 - 3.8e-06 27.1 10.0 3.8e-06 27.1 10.0 3.7 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFA81724.1 - 1.3e-05 25.0 11.1 1.3e-05 25.0 11.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA81724.1 - 0.0051 16.6 12.4 0.0051 16.6 12.4 4.0 3 2 1 4 4 4 1 Prokaryotic RING finger family 4 XPG_N PF00752.17 EFA81725.1 - 0.0029 18.0 0.1 0.012 16.0 0.1 2.1 1 1 0 1 1 1 1 XPG N-terminal domain Tex_N PF09371.10 EFA81725.1 - 0.077 12.7 0.9 0.17 11.6 0.9 1.5 1 0 0 1 1 1 0 Tex-like protein N-terminal domain DDE_Tnp_1_7 PF13843.6 EFA81726.1 - 2.3e-27 96.3 1.0 3.5e-27 95.6 1.0 1.2 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1 PF01609.21 EFA81726.1 - 0.0057 16.3 0.0 0.02 14.5 0.0 1.9 1 0 0 1 1 1 1 Transposase DDE domain RPN2_C PF18004.1 EFA81726.1 - 0.0059 16.5 0.4 0.013 15.5 0.4 1.5 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4558 PF15104.6 EFA81726.1 - 0.22 11.6 9.0 2.1 8.5 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) XPG_N PF00752.17 EFA81727.1 - 0.00055 20.4 0.0 0.0016 18.9 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EFA81727.1 - 0.0073 15.8 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.18 EFA81727.1 - 0.016 15.6 0.0 0.035 14.5 0.0 1.6 1 0 0 1 1 1 0 XPG I-region PPR_2 PF13041.6 EFA81728.1 - 0.00029 21.0 3.6 1.2 9.4 0.1 5.4 5 0 0 5 5 5 2 PPR repeat family CNOT11 PF10155.9 EFA81728.1 - 0.011 15.9 1.9 1.2 9.3 0.0 3.8 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 DDRGK PF09756.9 EFA81729.1 - 1.7e-58 197.3 34.5 1.7e-58 197.3 34.5 1.9 2 0 0 2 2 2 1 DDRGK domain RecQ_Zn_bind PF16124.5 EFA81729.1 - 8.7 7.2 8.9 1.7 9.4 2.0 3.0 1 1 1 2 2 2 0 RecQ zinc-binding SRI PF08236.11 EFA81730.1 - 1.7e-07 31.3 10.3 1.7e-07 31.3 10.3 4.2 5 2 0 5 5 5 1 SRI (Set2 Rpb1 interacting) domain Y_phosphatase3 PF13350.6 EFA81731.1 - 4.4e-05 23.6 0.1 0.00018 21.5 0.0 2.0 2 0 0 2 2 2 1 Tyrosine phosphatase family Oxysterol_BP PF01237.18 EFA81732.1 - 1.3e-52 178.9 5.7 6.5e-47 160.1 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein DUF3128 PF11326.8 EFA81732.1 - 1.3 9.4 3.3 0.77 10.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3128) 7tm_3 PF00003.22 EFA81733.1 - 1.6e-40 139.3 25.1 1.6e-40 139.3 25.1 1.5 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA81733.1 - 7.6e-26 90.8 2.8 1.2e-25 90.1 2.8 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like Syndecan PF01034.20 EFA81733.1 - 8.3 6.4 9.4 0.24 11.3 1.6 2.6 2 0 0 2 2 2 0 Syndecan domain RRP7 PF12923.7 EFA81734.1 - 1.5e-27 96.1 17.4 1.5e-27 96.1 17.4 4.9 3 1 0 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Coilin_N PF15862.5 EFA81734.1 - 0.12 12.2 0.1 0.12 12.2 0.1 6.1 4 2 3 7 7 7 0 Coilin N-terminus SR-25 PF10500.9 EFA81735.1 - 5.5e-15 55.6 81.1 5.5e-15 55.6 81.1 3.0 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein HIT PF01230.23 EFA81736.1 - 1.4e-23 83.4 0.0 1.6e-23 83.2 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFA81736.1 - 2.3e-17 63.5 0.0 2.6e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CDH PF02611.15 EFA81736.1 - 0.01 15.5 0.2 0.016 14.8 0.2 1.5 1 1 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase Pescadillo_N PF06732.11 EFA81738.1 - 1.5e-110 369.1 9.1 1.5e-110 369.1 9.1 2.2 2 1 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EFA81738.1 - 5.5e-11 42.7 1.5 9.5e-11 42.0 0.1 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA81738.1 - 3.6e-05 24.1 0.0 0.00023 21.5 0.0 2.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFA81738.1 - 0.033 14.5 0.6 0.16 12.3 0.0 2.6 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Syntaxin PF00804.25 EFA81739.1 - 3.4e-42 144.4 9.8 3.4e-42 144.4 9.8 1.9 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 EFA81739.1 - 9.6e-14 51.1 2.3 2.3e-13 49.9 2.3 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 EFA81739.1 - 0.00023 21.5 7.6 0.00023 21.5 7.6 2.4 2 1 0 2 2 2 1 Syntaxin-like protein OppC_N PF12911.7 EFA81739.1 - 0.042 13.8 0.4 0.08 12.9 0.4 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C VitD-bind_III PF09164.10 EFA81739.1 - 0.077 13.0 1.4 0.21 11.6 0.2 2.1 2 0 0 2 2 2 0 Vitamin D binding protein, domain III FlaC_arch PF05377.11 EFA81739.1 - 0.29 11.5 8.0 14 6.2 0.0 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) V-SNARE PF05008.15 EFA81739.1 - 1.2 9.6 11.0 3.7 8.0 0.2 3.5 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Tup_N PF08581.10 EFA81739.1 - 5 7.5 13.6 6.2 7.2 5.0 3.4 3 1 0 3 3 3 0 Tup N-terminal PRKG1_interact PF15898.5 EFA81739.1 - 5.1 8.1 11.3 2.8 8.9 6.8 2.6 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Peptidase_C1 PF00112.23 EFA81740.1 - 1.6e-77 260.5 10.5 3.5e-77 259.4 10.5 1.6 1 1 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA81740.1 - 6.8e-16 58.5 3.2 1.2e-15 57.7 3.2 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA81740.1 - 0.00059 18.7 4.6 0.099 11.4 0.1 2.6 2 1 1 3 3 3 2 Peptidase C1-like family DUF148 PF02520.17 EFA81740.1 - 0.1 12.8 0.2 0.17 12.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 FtsJ PF01728.19 EFA81741.1 - 5.4e-07 29.9 0.0 1.7e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase Porin_OmpL1 PF11389.8 EFA81741.1 - 0.024 13.9 0.4 0.044 13.0 0.4 1.4 1 1 0 1 1 1 0 Leptospira porin protein OmpL1 Swi5 PF07061.11 EFA81742.1 - 6.1e-20 71.1 5.2 8.8e-20 70.6 5.2 1.2 1 0 0 1 1 1 1 Swi5 IFT57 PF10498.9 EFA81742.1 - 0.00045 19.3 1.7 0.00048 19.2 1.7 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 ERM PF00769.19 EFA81742.1 - 0.011 15.5 4.4 0.014 15.2 4.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ApoLp-III PF07464.11 EFA81742.1 - 0.014 15.5 1.0 0.032 14.3 0.6 1.8 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) E2F_CC-MB PF16421.5 EFA81742.1 - 0.019 15.3 2.2 0.023 15.0 1.2 1.6 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain DUF4164 PF13747.6 EFA81742.1 - 0.022 15.0 0.5 0.031 14.6 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DUF4988 PF16378.5 EFA81742.1 - 0.074 12.7 2.6 0.091 12.4 1.0 1.9 1 1 1 2 2 2 0 Domain of unknown function Osmo_CC PF08946.10 EFA81742.1 - 0.089 13.1 1.3 0.089 13.1 1.3 2.0 1 1 1 2 2 2 0 Osmosensory transporter coiled coil DUF2397 PF09660.10 EFA81742.1 - 0.15 10.9 0.0 0.18 10.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) Spc24 PF08286.11 EFA81742.1 - 0.66 10.3 7.9 0.18 12.1 3.9 1.9 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 DUF1283 PF06932.11 EFA81742.1 - 1.4 9.2 5.6 1.3 9.2 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1283) DUF2951 PF11166.8 EFA81742.1 - 2.8 8.2 11.5 3.1 8.1 2.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) ubiquitin PF00240.23 EFA81743.1 - 3.4e-29 100.4 0.3 5.7e-29 99.7 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EFA81743.1 - 5.3e-23 80.9 1.6 5.3e-23 80.9 1.6 1.7 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EFA81743.1 - 4.6e-12 45.6 0.1 8.5e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA81743.1 - 6e-05 23.4 0.1 0.00029 21.2 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA81743.1 - 0.0048 17.0 0.1 0.0098 16.0 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFA81743.1 - 0.0082 16.5 0.6 0.017 15.4 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 EFA81743.1 - 0.0095 16.5 0.2 0.013 16.1 0.2 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 EFA81743.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain IBR PF01485.21 EFA81743.1 - 0.018 15.2 0.2 0.033 14.4 0.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain G6PD_C PF02781.16 EFA81744.1 - 5.8e-112 373.6 0.0 9.1e-112 373.0 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EFA81744.1 - 2.8e-56 190.9 0.0 4.4e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Bromodomain PF00439.25 EFA81745.1 - 7.3e-20 70.8 0.0 1.9e-19 69.5 0.0 1.8 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 EFA81745.1 - 1.1e-05 25.2 1.1 1.1e-05 25.2 1.1 2.4 3 0 0 3 3 3 1 PHD-finger PHD_2 PF13831.6 EFA81745.1 - 0.00067 19.2 1.8 0.00067 19.2 1.8 2.0 2 0 0 2 2 2 1 PHD-finger Exonuc_VII_L PF02601.15 EFA81745.1 - 0.18 11.4 8.9 0.03 13.9 5.2 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit AAA_23 PF13476.6 EFA81745.1 - 1.5 9.3 10.2 0.47 10.9 3.1 2.4 2 0 0 2 2 2 0 AAA domain PCMT PF01135.19 EFA81746.1 - 1.9e-64 217.3 0.1 2.4e-64 217.0 0.1 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFA81746.1 - 1.8e-08 34.4 0.1 2.4e-08 33.9 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA81746.1 - 6.6e-06 26.7 0.0 1.4e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA81746.1 - 2.6e-05 23.8 0.2 3.6e-05 23.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EFA81746.1 - 3.7e-05 23.6 0.0 5.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA81746.1 - 0.00015 21.3 0.2 0.0004 20.0 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFA81746.1 - 0.00039 20.4 0.1 0.00068 19.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EFA81746.1 - 0.001 19.2 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.7 EFA81746.1 - 0.0011 18.9 0.1 0.0023 17.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA81746.1 - 0.0013 19.3 0.0 0.0026 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA81746.1 - 0.0014 18.0 0.0 0.0023 17.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Morc6_S5 PF17942.1 EFA81746.1 - 0.0014 18.6 0.0 0.0067 16.5 0.0 1.9 2 0 0 2 2 2 1 Morc6 ribosomal protein S5 domain 2-like Fibrillarin PF01269.17 EFA81746.1 - 0.002 17.3 0.1 0.0046 16.1 0.1 1.6 2 0 0 2 2 2 1 Fibrillarin Methyltransf_16 PF10294.9 EFA81746.1 - 0.014 15.2 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 EFA81746.1 - 0.026 15.6 0.0 0.046 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 EFA81746.1 - 0.028 14.1 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_3 PF01596.17 EFA81746.1 - 0.041 13.0 0.0 0.083 12.1 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase CMAS PF02353.20 EFA81746.1 - 0.049 12.9 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase V_cholerae_RfbT PF05575.11 EFA81746.1 - 0.082 12.2 0.1 0.16 11.2 0.0 1.4 2 0 0 2 2 2 0 Vibrio cholerae RfbT protein MIP PF00230.20 EFA81747.1 - 1.9e-21 76.8 6.4 2.9e-21 76.2 6.4 1.2 1 0 0 1 1 1 1 Major intrinsic protein Exo_endo_phos PF03372.23 EFA81747.1 - 1.3e-06 28.2 0.1 3.3e-06 26.8 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GDYXXLXY PF14345.6 EFA81747.1 - 0.076 12.8 0.4 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 GDYXXLXY protein Exo_endo_phos_2 PF14529.6 EFA81747.1 - 0.73 9.7 6.0 0.76 9.6 0.7 3.3 3 1 0 3 3 3 0 Endonuclease-reverse transcriptase MIP PF00230.20 EFA81749.1 - 7.2e-20 71.7 4.6 9.7e-20 71.2 4.6 1.1 1 0 0 1 1 1 1 Major intrinsic protein SNRNP27 PF08648.12 EFA81749.1 - 0.051 13.7 0.8 0.14 12.2 0.8 1.7 1 0 0 1 1 1 0 U4/U6.U5 small nuclear ribonucleoproteins Asp5 PF17000.5 EFA81749.1 - 0.15 12.2 5.1 11 6.2 0.0 2.8 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 Peptidase_C1 PF00112.23 EFA81750.1 - 5e-61 206.6 1.6 8.2e-61 205.9 1.6 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA81750.1 - 9.4e-15 54.8 1.9 1.7e-14 54.0 1.9 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) EGF_2 PF07974.13 EFA81751.1 - 2.5e-09 37.3 53.6 0.0058 17.0 12.3 3.4 2 1 1 3 3 3 3 EGF-like domain EGF_Tenascin PF18720.1 EFA81751.1 - 0.00044 20.2 8.6 0.00044 20.2 8.6 3.4 3 0 0 3 3 3 1 Tenascin EGF domain RIFIN PF02009.16 EFA81751.1 - 0.26 11.2 1.9 0.51 10.2 1.9 1.5 1 0 0 1 1 1 0 Rifin PQQ_3 PF13570.6 EFA81751.1 - 0.51 10.9 7.2 1.2 9.7 0.0 4.0 4 1 0 4 4 4 0 PQQ-like domain Sporozoite_P67 PF05642.11 EFA81751.1 - 1.4 6.9 13.1 2 6.4 13.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen hEGF PF12661.7 EFA81751.1 - 3.8 8.3 46.1 0.34 11.6 6.0 3.8 3 0 0 3 3 3 0 Human growth factor-like EGF Laminin_EGF PF00053.24 EFA81751.1 - 6.3 7.0 45.7 1.3 9.2 10.0 3.3 1 1 2 3 3 3 0 Laminin EGF domain polyprenyl_synt PF00348.17 EFA81752.1 - 6.3e-71 238.4 0.5 1e-70 237.7 0.0 1.5 2 0 0 2 2 2 1 Polyprenyl synthetase Tipalpha PF16753.5 EFA81752.1 - 0.55 10.1 4.1 1 9.2 3.0 2.0 3 0 0 3 3 3 0 TNF-alpha-Inducing protein of Helicobacter PGAP1 PF07819.13 EFA81753.1 - 1.7e-70 237.3 0.0 3.1e-70 236.5 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFA81753.1 - 0.024 15.2 0.0 0.044 14.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA81753.1 - 0.03 13.6 0.0 0.064 12.5 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 EFA81753.1 - 0.079 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EFA81753.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Tmpp129 PF10272.9 EFA81754.1 - 1.7e-07 30.9 13.4 3.3e-07 30.0 13.4 1.6 1 0 0 1 1 1 1 Putative transmembrane protein precursor HypF_C PF17788.1 EFA81754.1 - 3.9 8.2 6.7 0.61 10.8 1.0 2.6 3 0 0 3 3 3 0 HypF Kae1-like domain CUE PF02845.16 EFA81755.1 - 1e-06 28.3 0.0 2.2e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 CUE domain USP8_dimer PF08969.11 EFA81756.1 - 0.035 14.3 0.1 0.035 14.3 0.1 2.1 3 0 0 3 3 3 0 USP8 dimerisation domain EF-hand_13 PF17958.1 EFA81756.1 - 0.048 13.5 0.2 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain PLDc_2 PF13091.6 EFA81758.1 - 1.4e-09 37.9 0.0 4.8e-05 23.3 0.0 2.9 2 1 1 3 3 3 2 PLD-like domain PLDc PF00614.22 EFA81758.1 - 1.6e-08 34.4 0.2 0.00083 19.4 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif FNIP PF05725.12 EFA81759.1 - 6.2e-29 99.9 7.9 1.2e-10 41.3 0.0 6.3 5 1 0 5 5 5 4 FNIP Repeat LRR_4 PF12799.7 EFA81759.1 - 3.1 8.4 21.8 4.6 7.8 0.1 7.1 7 3 1 8 8 8 0 Leucine Rich repeats (2 copies) Tecti-min-caps PF09300.10 EFA81761.1 - 0.00062 19.8 13.6 18 5.5 0.3 8.3 1 1 10 11 11 11 1 Tectiviridae, minor capsid SH3_5 PF08460.10 EFA81761.1 - 0.025 14.7 62.3 2.2 8.5 0.6 11.3 2 2 11 13 13 13 0 Bacterial SH3 domain Phage_30_3 PF08010.11 EFA81761.1 - 0.072 12.9 35.2 2.8 7.8 0.3 9.1 1 1 6 10 10 10 0 Bacteriophage protein GP30.3 CAMP_factor PF07373.11 EFA81761.1 - 6.5 6.3 7.7 73 2.9 0.1 5.7 8 4 3 11 11 11 0 CAMP factor (Cfa) Peptidase_S10 PF00450.22 EFA81762.1 - 1.6e-101 340.7 1.8 2.3e-101 340.2 1.8 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase WD40 PF00400.32 EFA81763.1 - 2.3e-43 145.3 31.5 1.7e-05 25.5 0.0 11.7 11 0 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA81763.1 - 1e-16 61.0 10.7 0.00021 21.5 0.1 7.8 4 2 4 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain DUF4062 PF13271.6 EFA81763.1 - 1.6e-13 50.8 0.0 4.6e-13 49.4 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) AAA_16 PF13191.6 EFA81763.1 - 4.8e-08 33.6 0.0 4.7e-07 30.3 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFA81763.1 - 1.1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain APAF1_C PF17908.1 EFA81763.1 - 1.7e-07 31.3 0.2 4.1e-06 26.8 0.2 3.0 2 1 0 2 2 1 1 APAF-1 helical domain AAA_22 PF13401.6 EFA81763.1 - 1.6e-06 28.4 0.0 5.1e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain eIF2A PF08662.11 EFA81763.1 - 7e-06 26.0 5.6 2.4 8.0 0.0 5.2 3 2 3 6 6 6 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFA81763.1 - 1.7e-05 24.3 5.6 0.0049 16.2 1.9 2.6 1 1 1 2 2 2 2 WD40-like domain PQQ PF01011.21 EFA81763.1 - 0.00065 19.5 2.2 2.2 8.4 0.4 4.8 5 0 0 5 5 5 1 PQQ enzyme repeat AAA PF00004.29 EFA81763.1 - 0.0013 19.1 0.0 0.0068 16.8 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFA81763.1 - 0.0081 16.5 0.0 1.4 9.4 0.0 3.3 3 0 0 3 3 3 1 RNA helicase Sigma54_activ_2 PF14532.6 EFA81763.1 - 0.047 13.8 0.3 1.3 9.1 0.1 3.1 3 1 0 3 3 3 0 Sigma-54 interaction domain BBS2_Mid PF14783.6 EFA81763.1 - 0.18 11.8 0.6 20 5.3 0.0 4.2 4 2 2 6 6 6 0 Ciliary BBSome complex subunit 2, middle region Peptidase_M23 PF01551.22 EFA81763.1 - 0.28 11.4 2.0 1.7 8.9 0.1 3.1 3 0 0 3 3 3 0 Peptidase family M23 Asp PF00026.23 EFA81764.1 - 0.011 15.1 0.5 0.07 12.5 0.0 2.1 2 1 0 2 2 2 0 Eukaryotic aspartyl protease Spp-24 PF07448.11 EFA81764.1 - 0.088 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain PH PF00169.29 EFA81765.1 - 1.8e-17 63.8 0.7 3.9e-17 62.7 0.4 1.7 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA81765.1 - 1.4e-06 28.4 0.2 2.6e-06 27.6 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFA81765.1 - 3.2e-06 27.5 2.0 2.5e-05 24.6 2.0 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EFA81765.1 - 9.4e-06 25.7 0.1 1.9e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 EFA81765.1 - 0.0044 17.3 0.1 0.034 14.4 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain DUF4003 PF13170.6 EFA81765.1 - 0.017 14.5 0.1 0.024 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) PH_9 PF15410.6 EFA81765.1 - 0.024 15.0 0.9 0.38 11.1 0.9 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 EFA81765.1 - 0.078 12.8 0.2 0.2 11.5 0.1 1.7 2 0 0 2 2 2 0 PH domain DEAD PF00270.29 EFA81766.1 - 4.6e-53 179.6 0.0 7.3e-53 178.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81766.1 - 3.5e-32 111.1 0.2 1.4e-29 102.7 0.1 3.1 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA81766.1 - 4.1e-06 26.9 0.0 8e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFA81766.1 - 0.051 12.9 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit TM1586_NiRdase PF14512.6 EFA81766.1 - 0.081 12.5 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative TM nitroreductase Clathrin PF00637.20 EFA81766.1 - 0.2 11.5 0.0 0.37 10.6 0.0 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS 7tm_3 PF00003.22 EFA81767.1 - 3.9e-20 72.6 34.5 1.9e-11 44.1 11.8 3.1 2 1 1 3 3 3 2 7 transmembrane sweet-taste receptor of 3 GCPR Med19 PF10278.9 EFA81768.1 - 5.3 6.9 29.2 26 4.7 18.4 3.2 1 1 1 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Methyltransf_2 PF00891.18 EFA81770.1 - 2.7e-31 108.5 0.1 3.5e-31 108.1 0.1 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA81770.1 - 6.7e-07 29.2 0.1 1.4e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.6 EFA81770.1 - 0.0085 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DTW PF03942.15 EFA81771.1 - 8.9e-41 139.8 3.6 1.9e-40 138.7 3.6 1.4 1 1 0 1 1 1 1 DTW domain Ribo_biogen_C PF04034.13 EFA81771.1 - 0.012 15.3 0.0 0.52 10.0 0.0 2.4 2 0 0 2 2 2 0 Ribosome biogenesis protein, C-terminal ssDNA-exonuc_C PF10141.9 EFA81771.1 - 0.085 12.5 2.5 0.1 12.2 0.5 2.1 1 1 1 2 2 2 0 Single-strand DNA-specific exonuclease, C terminal domain Secretin_N_2 PF07655.13 EFA81771.1 - 0.3 11.7 27.1 0.3 11.7 5.8 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain CPSase_L_D2 PF02786.17 EFA81772.1 - 3.3e-116 386.2 0.2 2.9e-85 285.1 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EFA81772.1 - 1.2e-47 161.0 0.0 4.7e-47 159.0 0.0 2.1 2 0 0 2 2 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 EFA81772.1 - 1.6e-44 151.5 0.0 4.6e-44 150.0 0.0 1.9 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 EFA81772.1 - 2.1e-43 148.3 0.0 5.6e-43 146.9 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EFA81772.1 - 1.2e-40 138.7 0.2 1.2e-40 138.7 0.2 2.4 3 0 0 3 3 3 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EFA81772.1 - 2.2e-32 112.3 0.1 7.2e-32 110.6 0.1 2.0 2 0 0 2 2 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Dala_Dala_lig_C PF07478.13 EFA81772.1 - 1.4e-23 83.5 1.0 5.2e-12 45.7 0.2 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFA81772.1 - 2e-18 66.5 0.1 9.9e-11 41.5 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 EFA81772.1 - 6.3e-14 51.9 0.0 3.5e-13 49.5 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain Amidohydro_1 PF01979.20 EFA81772.1 - 4.5e-11 42.6 0.9 2.6e-10 40.1 0.9 2.2 1 1 0 1 1 1 1 Amidohydrolase family ATPgrasp_Ter PF15632.6 EFA81772.1 - 5.8e-11 42.3 0.0 6e-05 22.8 0.0 2.9 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EFA81772.1 - 1.1e-10 41.8 0.7 2.7e-05 24.2 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 EFA81772.1 - 0.00031 20.6 0.2 0.56 9.9 0.1 2.7 1 1 1 2 2 2 2 Peptidase C26 GARS_A PF01071.19 EFA81772.1 - 0.00039 20.3 0.0 0.018 14.9 0.0 2.6 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DHOase PF12890.7 EFA81772.1 - 0.08 12.9 0.2 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Dihydro-orotase-like BRCT PF00533.26 EFA81773.1 - 4.2e-37 126.4 17.8 1.9e-09 37.8 0.2 8.1 8 1 0 8 8 8 6 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA81773.1 - 4.1e-34 116.8 9.6 3.5e-07 30.5 0.1 6.8 5 1 1 6 6 6 6 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFA81773.1 - 4.7e-31 106.5 5.9 7.2e-18 64.3 0.0 6.1 7 0 0 7 7 7 4 twin BRCT domain LIG3_BRCT PF16759.5 EFA81773.1 - 2.5e-15 56.5 1.6 0.2 11.9 0.0 7.7 7 1 0 7 7 7 5 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EFA81773.1 - 5.1e-12 45.6 1.7 2.1e-05 24.3 0.0 6.0 6 0 0 6 6 6 2 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EFA81773.1 - 1.5e-09 37.8 0.3 0.0021 18.1 0.1 5.3 6 0 0 6 6 6 2 BRCA1 C Terminus (BRCT) domain RL11D PF11088.8 EFA81773.1 - 0.1 12.9 0.0 0.46 10.8 0.0 2.1 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 RasGEF_N PF00618.20 EFA81773.1 - 0.18 12.1 1.1 1.6 9.0 0.0 3.1 3 0 0 3 3 3 0 RasGEF N-terminal motif MPP6 PF10175.9 EFA81773.1 - 2.1 8.9 6.4 24 5.4 1.2 2.9 2 0 0 2 2 2 0 M-phase phosphoprotein 6 V-ATPase_C PF03223.15 EFA81774.1 - 4.9e-117 391.5 10.3 5.8e-117 391.2 10.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C IL2 PF00715.17 EFA81774.1 - 0.052 13.5 2.4 1.3 9.0 0.0 3.2 3 1 0 3 3 3 0 Interleukin 2 Ank_2 PF12796.7 EFA81775.1 - 1.9e-26 92.4 4.8 5e-10 39.8 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81775.1 - 1.9e-24 85.7 0.9 2.3e-12 47.1 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA81775.1 - 1.5e-22 79.0 8.4 3.6e-07 30.3 0.1 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EFA81775.1 - 2.2e-22 76.7 3.3 6.7e-05 23.0 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFA81775.1 - 1.1e-21 76.6 2.3 5e-09 36.2 0.1 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) RE_NgoBV PF09564.10 EFA81775.1 - 0.69 9.3 3.9 2.3 7.6 0.3 2.8 3 0 0 3 3 3 0 NgoBV restriction endonuclease MCM PF00493.23 EFA81776.1 - 7e-104 345.8 0.3 1.4e-103 344.9 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EFA81776.1 - 1.1e-35 122.2 0.1 2.1e-35 121.3 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFA81776.1 - 6.4e-28 97.0 0.8 1.4e-27 95.9 0.8 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFA81776.1 - 5.9e-18 65.4 4.8 1.3e-17 64.2 4.8 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFA81776.1 - 2e-06 27.3 0.0 0.0011 18.3 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA81776.1 - 1.7e-05 24.8 0.0 3.8e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFA81776.1 - 0.00024 20.9 0.0 0.00092 19.1 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFA81776.1 - 0.042 13.5 0.1 0.28 10.9 0.1 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 EFA81776.1 - 0.17 12.5 0.2 1.4 9.6 0.2 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal ABC_tran PF00005.27 EFA81777.1 - 6.5e-47 159.5 0.5 3e-22 79.6 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EFA81777.1 - 1.4e-34 119.7 60.1 3.7e-20 72.3 24.6 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EFA81777.1 - 9.3e-20 71.6 1.8 2.8e-07 30.6 0.0 4.1 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA81777.1 - 8.9e-06 25.3 0.1 0.11 12.0 0.0 3.0 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFA81777.1 - 0.0001 22.1 0.1 0.33 10.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EFA81777.1 - 0.00014 22.3 0.4 0.012 16.0 0.0 3.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EFA81777.1 - 0.00065 19.4 1.5 0.16 11.6 0.2 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 EFA81777.1 - 0.0014 18.9 0.0 2.1 8.6 0.0 3.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EFA81777.1 - 0.0015 18.3 0.0 0.99 9.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFA81777.1 - 0.0063 16.4 0.3 0.58 10.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EFA81777.1 - 0.071 12.9 2.6 0.77 9.5 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFA81777.1 - 0.099 13.1 3.0 3.4 8.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFA81777.1 - 0.11 12.6 0.2 20 5.3 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 EFA81777.1 - 0.77 9.8 3.2 7 6.7 0.6 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain Zip PF02535.22 EFA81779.1 - 0.82 8.8 4.8 1.2 8.3 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter IMUP PF15761.5 EFA81779.1 - 2 9.1 12.1 3.7 8.3 12.1 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 EFA81779.1 - 2.8 7.5 23.5 1.4 8.4 21.4 1.4 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein XRCC4 PF06632.12 EFA81779.1 - 4.4 6.0 13.3 6.4 5.5 13.3 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 GMC_oxred_N PF00732.19 EFA81780.1 - 2.5e-43 148.6 0.0 4.2e-43 147.8 0.0 1.4 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA81780.1 - 4.3e-27 95.4 0.0 7.3e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EFA81780.1 - 0.029 13.6 0.0 0.15 11.3 0.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA81780.1 - 0.09 12.3 0.0 0.77 9.3 0.0 2.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFA81780.1 - 0.11 11.7 0.0 14 4.8 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Steroid_dh PF02544.16 EFA81781.1 - 4.2e-39 133.9 1.8 4.2e-39 133.9 1.8 1.8 3 0 0 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EFA81781.1 - 9.6e-07 28.6 3.4 1.4e-06 28.0 3.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EFA81781.1 - 6e-05 23.4 2.5 0.0002 21.7 2.5 1.8 1 1 0 1 1 1 1 Phospholipid methyltransferase ubiquitin PF00240.23 EFA81781.1 - 0.0036 17.0 0.2 0.009 15.7 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin family ICMT PF04140.14 EFA81781.1 - 0.078 13.4 1.0 0.16 12.4 0.4 1.9 1 1 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Orai-1 PF07856.12 EFA81781.1 - 0.27 10.9 2.6 0.34 10.6 1.5 1.7 1 1 0 1 1 1 0 Mediator of CRAC channel activity Peptidase_M48 PF01435.18 EFA81782.1 - 3e-22 79.3 0.1 2.9e-14 53.3 0.0 3.0 2 1 1 3 3 3 2 Peptidase family M48 Peptidase_M48_N PF16491.5 EFA81782.1 - 1.3e-14 54.6 16.0 1.5e-07 31.5 0.7 2.6 2 0 0 2 2 2 2 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M56 PF05569.11 EFA81782.1 - 0.00023 20.5 2.5 0.00047 19.5 0.7 2.3 2 1 0 2 2 2 1 BlaR1 peptidase M56 DUF1634 PF07843.11 EFA81782.1 - 0.089 12.9 1.2 0.34 11.0 0.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1634) zf-DBF PF07535.12 EFA81783.1 - 2.2e-18 66.1 3.4 2.2e-18 66.1 3.4 2.8 3 0 0 3 3 3 1 DBF zinc finger Peptidase_M24 PF00557.24 EFA81784.1 - 1.4e-37 129.4 0.3 2.1e-37 128.8 0.3 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 DDHD PF02862.17 EFA81784.1 - 0.017 15.3 4.1 0.029 14.5 4.1 1.3 1 0 0 1 1 1 0 DDHD domain NST1 PF13945.6 EFA81784.1 - 0.09 12.9 9.4 0.15 12.2 9.4 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator YL1 PF05764.13 EFA81784.1 - 0.14 12.2 13.1 0.21 11.7 13.1 1.1 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 EFA81784.1 - 0.26 9.5 6.6 0.36 9.1 6.6 1.2 1 0 0 1 1 1 0 CDC45-like protein SOG2 PF10428.9 EFA81784.1 - 0.44 9.7 5.4 0.67 9.1 5.4 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4778 PF16008.5 EFA81784.1 - 1.1 9.3 4.2 1.5 8.8 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) TFIIF_alpha PF05793.12 EFA81784.1 - 1.8 7.0 17.3 2.6 6.5 17.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mitofilin PF09731.9 EFA81784.1 - 1.9 7.2 12.6 2.6 6.8 12.6 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF913 PF06025.12 EFA81784.1 - 3.2 6.6 6.5 53 2.6 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Apt1 PF10351.9 EFA81784.1 - 4.1 6.1 8.2 6.1 5.6 8.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain GST_C_3 PF14497.6 EFA81785.1 - 3.6e-19 68.8 0.1 6.3e-19 68.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA81785.1 - 6.1e-08 32.9 0.0 1.2e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA81785.1 - 3.1e-06 27.3 0.0 4.3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA81785.1 - 0.0013 18.7 0.0 0.0038 17.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain E1-E2_ATPase PF00122.20 EFA81786.1 - 1.5e-50 171.3 3.9 1.5e-50 171.3 3.9 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFA81786.1 - 4.3e-47 161.1 0.2 6.6e-47 160.5 0.2 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFA81786.1 - 1.2e-22 80.1 0.1 1.8e-10 41.1 0.0 2.9 2 0 0 2 2 2 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EFA81786.1 - 0.00041 20.2 5.5 0.00095 19.0 0.7 3.3 3 1 1 4 4 4 1 haloacid dehalogenase-like hydrolase Ank_4 PF13637.6 EFA81787.1 - 2.4e-21 75.8 8.3 0.00011 22.7 0.2 7.5 5 3 2 7 7 7 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81787.1 - 2.1e-19 69.9 4.4 2.1e-05 25.0 0.0 5.5 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81787.1 - 1.1e-11 43.9 4.8 0.023 15.2 0.0 8.7 9 0 0 9 9 9 2 Ankyrin repeat Ank_5 PF13857.6 EFA81787.1 - 9.9e-06 25.7 8.2 1.4 9.3 0.1 6.4 4 1 4 8 8 8 3 Ankyrin repeats (many copies) Evr1_Alr PF04777.13 EFA81787.1 - 0.016 15.6 1.0 0.062 13.8 1.0 2.0 1 0 0 1 1 1 0 Erv1 / Alr family HA2 PF04408.23 EFA81788.1 - 2.1e-21 76.3 0.0 2.1e-21 76.3 0.0 5.3 3 1 0 3 3 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA81788.1 - 4e-14 52.7 0.0 9.2e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFA81788.1 - 4e-13 49.7 0.0 1.1e-12 48.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA81788.1 - 1.6e-06 28.0 0.0 4.3e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA81788.1 - 1.6e-05 25.2 0.0 4.8e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA81788.1 - 0.00016 22.1 0.0 0.00044 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA81788.1 - 0.00046 20.0 0.0 0.00097 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFA81788.1 - 0.018 14.4 0.0 0.047 13.0 0.0 1.6 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 EFA81788.1 - 0.027 14.1 0.0 0.062 12.9 0.0 1.7 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EFA81788.1 - 0.048 13.7 0.1 0.43 10.6 0.1 2.6 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFA81788.1 - 0.063 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.14 EFA81788.1 - 0.063 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_23 PF13476.6 EFA81788.1 - 0.077 13.5 0.0 0.077 13.5 0.0 5.1 3 1 0 4 4 2 0 AAA domain ABC_tran PF00005.27 EFA81788.1 - 0.12 12.9 0.0 0.12 12.9 0.0 2.9 3 1 0 3 3 1 0 ABC transporter NUDIX PF00293.28 EFA81789.1 - 1.3e-19 70.5 0.0 2.3e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Ac76 PF05814.11 EFA81789.1 - 0.037 14.0 1.6 0.076 13.0 1.6 1.5 1 0 0 1 1 1 0 Orf76 (Ac76) MFS_1 PF07690.16 EFA81790.1 - 1.3e-38 132.8 14.1 1.3e-38 132.8 14.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily BTB PF00651.31 EFA81791.1 - 4.6e-17 62.3 0.0 9.5e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EFA81791.1 - 2.2e-06 27.7 0.6 6e-06 26.3 0.1 2.1 3 0 0 3 3 3 1 BTB And C-terminal Kelch GMC_oxred_N PF00732.19 EFA81792.1 - 2e-42 145.6 0.1 5.1e-42 144.3 0.1 1.6 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA81792.1 - 6.3e-25 88.4 0.0 9.5e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFA81792.1 - 0.045 12.8 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.14 EFA81792.1 - 0.082 12.1 0.0 0.22 10.7 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EFA81792.1 - 0.12 12.7 0.2 0.39 11.0 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain DAO PF01266.24 EFA81792.1 - 0.12 11.9 0.0 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA81792.1 - 0.14 12.4 0.1 0.42 10.9 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FNIP PF05725.12 EFA81793.1 - 4.2e-72 238.1 59.2 5.2e-14 52.1 0.5 8.6 5 2 5 10 10 10 10 FNIP Repeat Pkinase PF00069.25 EFA81793.1 - 1.1e-31 110.2 1.4 6e-31 107.8 1.4 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81793.1 - 1.4e-14 54.1 0.6 2.5e-14 53.2 0.6 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA81793.1 - 0.00075 19.5 0.0 0.011 15.6 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Syntaxin_2 PF14523.6 EFA81795.1 - 6.9e-07 29.6 5.2 1.3e-06 28.7 1.5 2.2 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EFA81795.1 - 3.1e-06 27.1 0.4 5.8e-06 26.2 0.4 1.4 1 0 0 1 1 1 1 SNARE domain IL31 PF15209.6 EFA81795.1 - 0.00049 19.9 1.9 0.0038 17.0 0.2 2.2 2 0 0 2 2 2 1 Interleukin 31 Rx_N PF18052.1 EFA81795.1 - 0.022 15.0 0.9 4.3 7.7 0.3 2.2 2 0 0 2 2 2 0 Rx N-terminal domain LolA_2 PF16584.5 EFA81795.1 - 0.056 13.3 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Acetyltransf_18 PF18014.1 EFA81795.1 - 0.11 12.3 0.1 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain ABC_tran_CTD PF16326.5 EFA81795.1 - 0.24 11.7 2.5 0.29 11.4 0.3 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain Flagellin_N PF00669.20 EFA81795.1 - 0.86 9.7 4.6 2.7 8.1 0.4 2.6 3 0 0 3 3 3 0 Bacterial flagellin N-terminal helical region Ank_2 PF12796.7 EFA81796.1 - 3.9e-25 88.2 9.7 1.4e-08 35.2 0.1 7.0 2 1 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81796.1 - 5.3e-25 87.5 8.8 0.00029 21.3 0.0 9.8 7 2 5 12 12 12 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81796.1 - 2.9e-20 70.2 7.5 0.14 12.8 0.0 13.0 12 2 2 14 14 14 2 Ankyrin repeat Ank_5 PF13857.6 EFA81796.1 - 6.1e-18 64.7 14.2 0.56 10.6 0.0 11.8 5 3 8 13 13 13 6 Ankyrin repeats (many copies) Ank PF00023.30 EFA81796.1 - 0.0021 18.4 4.2 0.11 13.0 0.0 5.7 8 0 0 8 8 8 1 Ankyrin repeat LANC_like PF05147.13 EFA81797.1 - 2.2e-57 194.3 3.2 3.8e-57 193.5 3.2 1.3 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Resolvase PF00239.21 EFA81800.1 - 1.1e-06 28.8 0.1 3.7e-05 23.9 0.0 2.5 2 0 0 2 2 2 1 Resolvase, N terminal domain DUF3446 PF11928.8 EFA81800.1 - 0.00016 21.9 3.5 0.00041 20.6 3.5 1.7 1 0 0 1 1 1 1 Early growth response N-terminal domain SR-25 PF10500.9 EFA81800.1 - 0.7 9.5 15.3 1.1 8.9 15.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HSBP1 PF06825.12 EFA81800.1 - 8 6.4 9.0 0.3 11.0 0.7 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 EFP PF01132.20 EFA81801.1 - 0.0053 16.8 0.0 0.0085 16.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain MIT_C PF16565.5 EFA81801.1 - 0.033 14.2 0.7 0.11 12.5 0.2 1.8 1 1 1 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT FPP PF05911.11 EFA81803.1 - 3.5e-06 25.6 24.1 4.7e-06 25.1 24.1 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 EFA81803.1 - 6e-06 25.4 21.8 6e-06 25.4 21.8 2.2 1 1 1 2 2 2 1 Spc7 kinetochore protein Cast PF10174.9 EFA81803.1 - 1.5e-05 23.4 24.3 2.1e-05 23.0 24.3 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone HrpB7 PF09486.10 EFA81803.1 - 0.0014 19.1 10.4 0.0014 19.1 10.4 2.1 2 1 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) GAS PF13851.6 EFA81803.1 - 0.0027 17.1 25.1 0.0027 17.1 25.1 2.8 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EFA81803.1 - 0.0029 17.7 27.3 0.015 15.3 9.0 3.2 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.11 EFA81803.1 - 0.0042 16.0 20.8 0.0059 15.5 20.8 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2203 PF09969.9 EFA81803.1 - 0.0042 17.8 14.2 0.082 13.6 3.4 2.8 2 1 1 3 3 3 2 Uncharacterized conserved protein (DUF2203) TMF_TATA_bd PF12325.8 EFA81803.1 - 0.0045 17.2 10.2 0.0045 17.2 10.2 2.9 2 1 1 3 3 3 1 TATA element modulatory factor 1 TATA binding TolA_bind_tri PF16331.5 EFA81803.1 - 0.0048 17.0 8.1 0.0091 16.1 0.6 3.2 3 0 0 3 3 3 1 TolA binding protein trimerisation ADIP PF11559.8 EFA81803.1 - 0.0092 16.1 17.0 0.0092 16.1 17.0 3.2 1 1 2 3 3 2 1 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EFA81803.1 - 0.0098 15.9 11.5 0.0098 15.9 11.5 2.7 2 1 1 3 3 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 EFA81803.1 - 0.011 16.2 18.5 0.011 16.2 18.5 2.6 1 1 1 2 2 2 0 Fez1 Flagellin_C PF00700.21 EFA81803.1 - 0.013 15.8 9.5 0.17 12.3 0.7 3.9 2 1 2 4 4 4 0 Bacterial flagellin C-terminal helical region WEMBL PF05701.11 EFA81803.1 - 0.016 13.9 21.1 0.028 13.1 21.1 1.4 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF4686 PF15742.5 EFA81803.1 - 0.018 14.2 29.3 0.31 10.1 13.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) Tropomyosin PF00261.20 EFA81803.1 - 0.023 14.0 28.0 0.086 12.2 6.4 2.8 2 1 1 3 3 3 0 Tropomyosin NBP1 PF08537.10 EFA81803.1 - 0.029 13.8 29.0 0.014 14.8 12.3 2.9 1 1 2 3 3 3 0 Fungal Nap binding protein NBP1 MtrG PF04210.13 EFA81803.1 - 0.056 13.3 4.3 1.8 8.5 0.1 3.8 1 1 4 5 5 5 0 Tetrahydromethanopterin S-methyltransferase, subunit G FliJ PF02050.16 EFA81803.1 - 0.067 13.4 14.9 0.1 12.8 0.8 3.0 2 1 1 3 3 3 0 Flagellar FliJ protein DUF745 PF05335.13 EFA81803.1 - 0.072 12.8 20.6 0.016 14.9 15.1 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF1192 PF06698.11 EFA81803.1 - 0.077 13.1 6.8 0.11 12.6 2.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) V-SNARE_C PF12352.8 EFA81803.1 - 0.1 12.9 11.0 3 8.2 0.2 4.5 2 1 2 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus DUF3552 PF12072.8 EFA81803.1 - 0.12 11.8 26.7 0.026 13.9 12.3 2.6 2 1 1 3 3 2 0 Domain of unknown function (DUF3552) Bcr-Abl_Oligo PF09036.10 EFA81803.1 - 0.13 12.3 5.0 16 5.5 1.4 3.5 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain COG2 PF06148.11 EFA81803.1 - 0.14 12.2 13.4 0.074 13.1 4.7 2.6 2 1 1 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TBCA PF02970.16 EFA81803.1 - 0.16 12.3 20.9 0.86 10.0 9.8 3.2 2 1 2 4 4 3 0 Tubulin binding cofactor A Sugarporin_N PF11471.8 EFA81803.1 - 0.19 11.7 7.9 0.9 9.5 1.3 3.6 2 1 0 3 3 3 0 Maltoporin periplasmic N-terminal extension Exonuc_VII_L PF02601.15 EFA81803.1 - 0.22 11.1 27.3 41 3.6 27.2 2.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit HIP1_clath_bdg PF16515.5 EFA81803.1 - 0.22 12.2 26.5 0.52 10.9 6.5 3.4 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DHR10 PF18595.1 EFA81803.1 - 0.22 11.6 29.4 0.089 12.8 9.9 3.0 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 EFA81803.1 - 0.24 11.8 13.1 4.1 7.9 3.3 4.7 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Filament PF00038.21 EFA81803.1 - 0.24 10.9 23.3 0.82 9.2 3.0 2.5 1 1 1 2 2 2 0 Intermediate filament protein Lebercilin PF15619.6 EFA81803.1 - 0.34 10.5 32.0 0.078 12.6 13.4 3.6 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.12 EFA81803.1 - 0.37 11.1 18.0 0.6 10.4 3.5 2.8 2 1 1 3 3 2 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.12 EFA81803.1 - 0.39 10.8 21.6 0.11 12.5 4.4 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EFA81803.1 - 0.45 10.5 25.4 0.31 11.1 7.0 3.3 1 1 1 3 3 3 0 Laminin Domain II THOC7 PF05615.13 EFA81803.1 - 0.85 9.9 22.9 4.6 7.5 4.5 3.4 1 1 1 2 2 2 0 Tho complex subunit 7 APG6_N PF17675.1 EFA81803.1 - 1.1 9.8 29.6 0.15 12.5 22.7 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region Tropomyosin_1 PF12718.7 EFA81803.1 - 1.6 8.9 32.0 0.28 11.3 26.2 2.6 2 1 0 2 2 1 0 Tropomyosin like SecD-TM1 PF13721.6 EFA81803.1 - 1.8 9.0 8.0 6.7 7.2 1.1 2.7 1 1 1 2 2 2 0 SecD export protein N-terminal TM region UPF0184 PF03670.13 EFA81803.1 - 1.9 9.0 12.3 4.9 7.6 0.4 3.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) DUF4407 PF14362.6 EFA81803.1 - 1.9 7.8 21.0 5.4 6.3 21.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Syntaxin-6_N PF09177.11 EFA81803.1 - 1.9 9.1 21.1 0.2 12.3 7.9 3.4 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Cluap1 PF10234.9 EFA81803.1 - 2 7.7 28.2 2.7 7.3 8.7 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 Exonuc_VII_S PF02609.16 EFA81803.1 - 2.5 8.2 5.7 10 6.3 2.3 3.1 2 2 1 3 3 3 0 Exonuclease VII small subunit DUF2730 PF10805.8 EFA81803.1 - 2.7 8.1 17.4 7 6.8 6.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) NPV_P10 PF05531.12 EFA81803.1 - 2.7 8.5 23.8 4.8 7.7 2.9 4.1 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Sec2p PF06428.11 EFA81803.1 - 2.9 7.9 31.8 0.27 11.2 4.1 4.2 2 1 2 4 4 4 0 GDP/GTP exchange factor Sec2p HMMR_N PF15905.5 EFA81803.1 - 3.8 6.9 30.6 15 4.9 30.5 1.9 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF3450 PF11932.8 EFA81803.1 - 4.8 6.4 20.2 2.1 7.6 4.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Pro_Al_protease PF02983.14 EFA81803.1 - 4.9 7.3 21.4 1.8e+04 -11.1 21.4 4.8 1 1 0 1 1 0 0 Alpha-lytic protease prodomain PEARLI-4 PF05278.12 EFA81803.1 - 6.1 6.4 16.8 8.8 5.8 7.0 2.6 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) IFT57 PF10498.9 EFA81803.1 - 6.9 5.5 27.6 0.12 11.3 10.9 2.9 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 Uso1_p115_C PF04871.13 EFA81803.1 - 7 7.0 33.2 11 6.4 9.6 3.2 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region V_ATPase_I PF01496.19 EFA81803.1 - 7.1 4.4 20.5 0.56 8.1 14.1 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family LRRFIP PF09738.9 EFA81803.1 - 9.4 5.6 29.2 0.33 10.4 7.0 2.7 1 1 1 2 2 2 0 LRRFIP family Elf1 PF05129.13 EFA81805.1 - 0.0029 17.6 0.8 0.051 13.6 0.2 2.4 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like DUF3439 PF11921.8 EFA81805.1 - 0.093 12.7 3.9 0.21 11.5 3.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CLP1_P PF16575.5 EFA81806.1 - 4.5e-41 140.7 0.1 2.3e-40 138.4 0.0 2.0 1 1 1 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Peptidase_C48 PF02902.19 EFA81807.1 - 5.1e-18 65.7 0.2 8.7e-18 65.0 0.2 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Amidohydro_3 PF07969.11 EFA81808.1 - 2.3e-18 66.9 0.6 3e-10 40.2 0.0 2.5 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 EFA81808.1 - 3.9e-17 62.6 0.3 7.4e-14 51.8 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family SHOCT PF09851.9 EFA81808.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Short C-terminal domain DJ-1_PfpI PF01965.24 EFA81809.1 - 3.2e-43 147.4 0.0 3.8e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family UDPGT PF00201.18 EFA81809.1 - 0.11 11.2 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Pkinase_Tyr PF07714.17 EFA81810.1 - 1.3e-63 214.7 0.0 2.7e-63 213.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA81810.1 - 2e-52 178.2 0.0 4.9e-52 176.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 EFA81810.1 - 8.1e-20 70.3 30.6 8e-13 48.0 8.1 3.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFA81810.1 - 4.4e-17 61.9 26.8 4.4e-09 36.5 5.9 5.8 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) APH PF01636.23 EFA81810.1 - 5.3e-05 23.3 5.5 0.00046 20.2 0.2 3.2 3 0 0 3 3 3 1 Phosphotransferase enzyme family LRR_6 PF13516.6 EFA81810.1 - 0.0054 16.7 18.9 0.036 14.1 0.1 5.6 5 0 0 5 5 5 1 Leucine Rich repeat zf-CCCH PF00642.24 EFA81812.1 - 1.8e-07 30.9 8.4 0.00011 22.0 1.5 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA81812.1 - 1.7e-06 27.9 19.9 0.0047 16.9 7.0 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EFA81812.1 - 4.8e-05 23.1 12.2 0.013 15.3 0.9 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EFA81812.1 - 0.00064 20.1 14.8 0.0083 16.6 5.0 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EFA81812.1 - 0.011 16.4 12.4 0.023 15.4 2.5 4.8 4 1 1 5 5 5 0 Torus domain PIP49_N PF14875.6 EFA81812.1 - 0.073 12.9 0.6 0.25 11.2 0.6 1.9 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 zf-CCCH_3 PF15663.5 EFA81812.1 - 0.22 11.7 11.3 0.9 9.8 0.1 4.0 4 1 0 4 4 4 0 Zinc-finger containing family TIG PF01833.24 EFA81813.1 - 0.034 14.2 1.5 0.05 13.7 1.5 1.2 1 0 0 1 1 1 0 IPT/TIG domain Cadherin_3 PF16184.5 EFA81813.1 - 0.086 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Cadherin-like RasGEF PF00617.19 EFA81814.1 - 3.5e-15 56.7 0.4 5.6e-15 56.0 0.0 1.5 2 0 0 2 2 2 1 RasGEF domain Orthoreo_P17 PF07272.11 EFA81814.1 - 0.14 12.2 0.9 0.43 10.6 0.1 2.0 2 0 0 2 2 2 0 Orthoreovirus P17 protein Foie-gras_1 PF11817.8 EFA81814.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Foie gras liver health family 1 DUF2353 PF09789.9 EFA81815.1 - 0.0002 20.8 9.7 0.00027 20.4 9.7 1.3 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) GldM_N PF12081.8 EFA81815.1 - 0.0031 17.6 3.7 0.0041 17.2 3.7 1.3 1 0 0 1 1 1 1 GldM N-terminal domain DUF5344 PF17279.2 EFA81815.1 - 0.048 14.2 3.3 0.048 14.2 3.3 2.0 1 1 0 2 2 2 0 Family of unknown function (DUF5344) SYCE1 PF15233.6 EFA81815.1 - 0.059 13.4 9.2 0.076 13.1 9.2 1.2 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 Par3_HAL_N_term PF12053.8 EFA81815.1 - 0.11 12.7 5.4 0.26 11.5 5.4 1.6 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins KIP1 PF07765.12 EFA81815.1 - 0.13 12.4 12.1 0.094 12.9 1.4 3.1 2 1 1 3 3 3 0 KIP1-like protein APG6_N PF17675.1 EFA81815.1 - 0.18 12.3 11.3 0.26 11.8 11.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region YtxH PF12732.7 EFA81815.1 - 0.27 11.8 2.3 0.84 10.2 2.3 2.0 1 1 0 1 1 1 0 YtxH-like protein Gp-FAR-1 PF05823.12 EFA81815.1 - 0.42 11.0 6.6 1.5 9.2 6.6 1.9 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CENP-H PF05837.12 EFA81815.1 - 2.5 8.6 10.1 10 6.6 8.0 2.2 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DNA_topoisoIV PF00521.20 EFA81815.1 - 3 6.6 9.9 3.3 6.5 9.9 1.0 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A adh_short PF00106.25 EFA81816.1 - 1.1e-43 149.0 0.0 1.8e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA81816.1 - 1.5e-33 116.3 0.0 2e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA81816.1 - 5.8e-07 29.6 0.0 9.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA81816.1 - 0.00017 21.2 0.1 0.00038 20.0 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EFA81816.1 - 0.0064 15.9 0.0 0.0091 15.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 EFA81816.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Pkinase PF00069.25 EFA81817.1 - 2.9e-75 253.0 0.0 2.9e-75 253.0 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81817.1 - 8.3e-34 117.0 0.0 1.6e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA81817.1 - 2.6e-06 27.0 0.0 2.6e-06 27.0 0.0 1.8 2 1 0 2 2 2 1 Kinase-like DSPc PF00782.20 EFA81818.1 - 3.6e-08 33.3 0.0 1.1e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFA81818.1 - 0.0063 16.5 0.0 0.0094 15.9 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFA81818.1 - 0.018 14.6 0.1 0.036 13.6 0.0 1.5 2 0 0 2 2 2 0 Protein-tyrosine phosphatase C2 PF00168.30 EFA81819.1 - 1.8e-12 47.4 0.1 2.7e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 C2 domain Ank_2 PF12796.7 EFA81820.1 - 4.3e-12 46.4 6.4 0.00064 20.3 0.2 4.7 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81820.1 - 3.5e-09 36.7 0.8 0.27 11.6 0.0 6.2 4 1 4 8 8 8 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA81820.1 - 3.3e-07 30.7 4.5 0.12 13.0 0.0 6.3 2 1 5 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81820.1 - 1.8e-05 24.8 0.0 3.8 8.4 0.0 6.3 8 0 0 8 8 8 2 Ankyrin repeat Ank_2 PF12796.7 EFA81821.1 - 1.4e-20 73.7 6.6 2.2e-05 25.0 0.0 5.5 2 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81821.1 - 7e-14 51.7 12.7 0.017 15.5 0.0 8.9 5 3 5 10 10 10 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA81821.1 - 6.5e-12 45.7 10.2 0.00016 22.1 0.0 8.4 5 3 3 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81821.1 - 9.2e-11 41.0 11.0 0.046 14.3 0.0 9.2 11 0 0 11 11 11 3 Ankyrin repeat Ank PF00023.30 EFA81821.1 - 0.05 14.1 2.4 2.2e+02 2.5 0.0 6.1 7 1 0 7 7 7 0 Ankyrin repeat DUF3447 PF11929.8 EFA81821.1 - 0.26 11.3 16.0 5.6 7.0 0.1 5.5 4 2 2 6 6 6 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA81824.1 - 2.3e-22 79.3 2.2 0.00083 19.9 0.1 5.9 2 1 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81824.1 - 6.9e-19 68.0 8.7 0.0011 19.5 0.1 8.7 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81824.1 - 1.5e-14 52.7 3.5 1 10.1 0.0 10.2 11 0 0 11 11 11 4 Ankyrin repeat Ank_5 PF13857.6 EFA81824.1 - 1e-13 51.2 9.8 0.017 15.5 0.0 8.2 4 2 5 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EFA81824.1 - 0.4 11.2 2.3 19 5.9 0.2 4.5 5 2 1 6 6 6 0 Ankyrin repeat FNIP PF05725.12 EFA81825.1 - 5.5e-09 36.1 0.0 1.3e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 FNIP Repeat F-box PF00646.33 EFA81825.1 - 8.2e-07 28.8 0.4 1.6e-06 27.9 0.4 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA81825.1 - 6.5e-05 22.8 0.5 0.00012 21.9 0.5 1.4 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA81825.1 - 0.0082 15.7 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 F-box PRKCSH_1 PF13015.6 EFA81825.1 - 0.054 13.2 0.1 0.11 12.2 0.1 1.5 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein RCC1 PF00415.18 EFA81827.1 - 2.3e-69 229.8 15.9 1.6e-13 51.1 0.9 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.25 EFA81827.1 - 5.8e-53 180.4 0.6 1.8e-52 178.8 0.6 1.8 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 EFA81827.1 - 2.5e-41 141.8 0.1 2.1e-40 138.8 0.1 2.6 1 1 0 1 1 1 1 Protein kinase domain RCC1_2 PF13540.6 EFA81827.1 - 1e-30 104.8 32.1 8.1e-08 31.9 0.3 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 EFA81827.1 - 1.4e-28 99.9 0.2 6.5e-28 97.7 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFA81827.1 - 0.00017 21.0 0.1 0.00034 20.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA81827.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ELO PF01151.18 EFA81828.1 - 2.5e-11 43.6 3.8 3e-11 43.3 3.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family PhoLip_ATPase_C PF16212.5 EFA81829.1 - 4.5e-10 39.7 9.6 5.7e-10 39.4 9.6 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_C PF16212.5 EFA81830.1 - 1.1e-40 139.9 1.3 1.1e-40 139.9 1.3 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EFA81830.1 - 6.7e-14 51.8 0.0 2.2e-12 46.9 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFA81830.1 - 1.1e-07 31.6 0.1 1.1e-07 31.6 0.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFA81830.1 - 1.4e-07 32.1 0.0 0.00082 19.7 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA81830.1 - 0.011 15.5 1.0 0.011 15.5 1.0 4.1 3 2 1 4 4 4 0 haloacid dehalogenase-like hydrolase SBDS_C PF09377.10 EFA81831.1 - 7.7e-37 125.9 2.9 1.4e-36 125.0 0.2 2.4 3 0 0 3 3 3 1 SBDS protein C-terminal domain SBDS PF01172.18 EFA81831.1 - 1e-31 108.8 0.5 2e-31 107.9 0.5 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein PhoLip_ATPase_N PF16209.5 EFA81831.1 - 3.9e-11 42.5 3.3 7.8e-11 41.5 3.3 1.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal CLTH PF10607.9 EFA81832.1 - 1.4e-19 70.5 13.0 2.6e-18 66.3 13.0 2.4 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain CAMP_factor PF07373.11 EFA81832.1 - 0.00041 20.0 1.9 0.00082 19.0 1.9 1.5 1 0 0 1 1 1 1 CAMP factor (Cfa) FapA PF03961.13 EFA81832.1 - 0.0007 18.3 6.9 0.0011 17.7 6.9 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A Mitofilin PF09731.9 EFA81832.1 - 0.00071 18.5 5.5 0.00094 18.1 5.5 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein TPR_MLP1_2 PF07926.12 EFA81832.1 - 0.0028 17.7 7.8 0.0091 16.1 7.8 1.8 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein DASH_Dad1 PF08649.10 EFA81832.1 - 0.0052 16.9 5.9 0.52 10.5 0.1 3.4 3 0 0 3 3 3 2 DASH complex subunit Dad1 ACCA PF03255.14 EFA81832.1 - 0.0087 15.9 4.1 0.02 14.8 4.1 1.5 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit U-box PF04564.15 EFA81832.1 - 0.019 15.1 1.3 0.2 11.9 0.0 2.8 2 0 0 2 2 2 0 U-box domain CLZ PF16526.5 EFA81832.1 - 0.026 14.9 4.6 0.026 14.9 4.6 2.2 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels LisH PF08513.11 EFA81832.1 - 0.032 14.2 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 LisH DUF883 PF05957.13 EFA81832.1 - 0.058 14.0 1.0 0.13 12.9 1.0 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF1840 PF08895.11 EFA81832.1 - 0.17 12.3 1.6 0.42 11.0 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) COG2 PF06148.11 EFA81832.1 - 0.18 11.9 5.8 0.68 10.0 5.8 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 OmpH PF03938.14 EFA81832.1 - 0.27 11.5 6.9 0.16 12.3 2.9 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Focal_AT PF03623.13 EFA81832.1 - 0.46 10.5 5.5 0.29 11.1 1.1 2.5 1 1 1 2 2 2 0 Focal adhesion targeting region Fzo_mitofusin PF04799.13 EFA81832.1 - 0.65 9.5 8.2 1.8 8.1 2.3 2.3 1 1 1 2 2 2 0 fzo-like conserved region DegS PF05384.11 EFA81832.1 - 0.9 9.0 10.6 3.6 7.1 4.8 2.2 1 1 1 2 2 2 0 Sensor protein DegS DUF2120 PF09893.9 EFA81832.1 - 0.96 9.6 4.7 4.1 7.5 3.9 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Frigida PF07899.11 EFA81832.1 - 1 8.6 9.8 3.1 7.0 7.8 2.1 2 0 0 2 2 2 0 Frigida-like protein CHD5 PF04420.14 EFA81832.1 - 1 9.2 4.0 1.9 8.4 4.0 1.3 1 0 0 1 1 1 0 CHD5-like protein GrpE PF01025.19 EFA81832.1 - 1.1 8.9 10.8 6.1 6.5 10.7 2.1 1 1 0 1 1 1 0 GrpE FGGY_C PF02782.16 EFA81833.1 - 0.041 13.6 0.6 0.084 12.6 0.6 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Vps36-NZF-N PF16988.5 EFA81834.1 - 0.002 17.5 0.3 0.005 16.2 0.3 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain ZZ PF00569.17 EFA81834.1 - 0.014 15.2 3.0 0.03 14.1 3.0 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type LSM PF01423.22 EFA81835.1 - 8e-20 70.3 0.0 1e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA81835.1 - 0.06 13.5 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain SapB_1 PF05184.15 EFA81836.1 - 1.1e-19 70.1 12.1 3.1e-13 49.4 0.4 2.7 3 0 0 3 3 3 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA81836.1 - 2.3e-08 34.0 0.7 7.6e-08 32.3 0.7 2.0 1 0 0 1 1 1 1 Saposin-like type B, region 2 DUF5332 PF17266.2 EFA81836.1 - 4 7.1 9.4 5.3 6.7 0.7 3.1 2 1 0 3 3 3 0 Family of unknown function (DUF5332) Melibiase_2 PF16499.5 EFA81837.1 - 2.8e-99 331.9 2.1 4e-99 331.4 2.1 1.2 1 0 0 1 1 1 1 Alpha galactosidase A DUF393 PF04134.12 EFA81837.1 - 3e-25 89.7 0.1 3e-25 89.7 0.1 2.3 3 0 0 3 3 1 1 Protein of unknown function, DUF393 Melibiase_C PF17801.1 EFA81837.1 - 2.6e-18 65.8 0.0 6.9e-18 64.5 0.0 1.8 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 EFA81837.1 - 1.3e-07 31.8 0.2 4.6e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase PF02065.18 EFA81837.1 - 5e-05 22.4 0.0 9.2e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Melibiase E7 PF00527.18 EFA81837.1 - 0.0056 16.8 0.4 0.011 15.9 0.4 1.4 1 0 0 1 1 1 1 E7 protein, Early protein DUF2722 PF10846.8 EFA81837.1 - 0.047 12.6 7.1 0.066 12.2 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Hormone_3 PF00159.18 EFA81837.1 - 0.059 13.5 0.1 0.19 11.8 0.0 1.9 2 0 0 2 2 1 0 Pancreatic hormone peptide DUF4799 PF16056.5 EFA81837.1 - 0.081 12.1 1.1 0.12 11.5 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) DUF4834 PF16118.5 EFA81837.1 - 0.49 11.4 2.5 0.7 10.9 1.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 EFA81837.1 - 8.2 6.0 17.4 13 5.3 17.4 1.2 1 0 0 1 1 1 0 Spt20 family Ank_4 PF13637.6 EFA81838.1 - 1.2e-18 67.1 2.3 0.00037 21.0 0.0 8.9 8 2 2 10 10 10 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81838.1 - 2e-18 66.2 7.1 0.0029 17.9 0.1 10.6 6 3 6 12 12 12 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81838.1 - 8.1e-18 64.8 5.8 0.00036 21.1 0.0 6.2 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA81838.1 - 8.8e-14 50.3 3.6 6.4 7.7 0.0 11.7 11 1 1 12 12 12 2 Ankyrin repeat DEP PF00610.21 EFA81838.1 - 0.0062 16.6 2.1 68 3.6 0.1 5.5 6 1 0 6 6 6 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ank PF00023.30 EFA81838.1 - 0.045 14.2 0.0 13 6.4 0.0 4.9 5 1 1 6 6 6 0 Ankyrin repeat PPR_long PF17177.4 EFA81838.1 - 0.081 12.3 0.5 0.23 10.8 0.1 1.9 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP MDM31_MDM32 PF08118.11 EFA81839.1 - 6e-85 285.9 21.1 7.4e-46 156.9 0.1 4.2 3 2 1 4 4 4 3 Yeast mitochondrial distribution and morphology (MDM) proteins LIM PF00412.22 EFA81840.1 - 4.6e-12 46.0 7.8 6.4e-12 45.5 7.8 1.2 1 0 0 1 1 1 1 LIM domain C1_1 PF00130.22 EFA81840.1 - 0.011 15.6 7.5 0.12 12.3 2.3 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4428 PF14471.6 EFA81840.1 - 0.12 12.3 4.8 0.73 9.8 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) TNFR_c6 PF00020.18 EFA81840.1 - 5.8 7.4 12.2 1.4 9.4 2.1 3.2 2 1 1 3 3 3 0 TNFR/NGFR cysteine-rich region Sld5 PF05916.11 EFA81841.1 - 1.2e-07 32.1 0.0 2e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein DNA_primase_lrg PF04104.14 EFA81842.1 - 2.3e-68 230.5 0.1 3.7e-68 229.8 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Exonuc_VII_S PF02609.16 EFA81843.1 - 0.058 13.5 1.1 1.2 9.3 0.1 2.5 2 0 0 2 2 2 0 Exonuclease VII small subunit Bromodomain PF00439.25 EFA81845.1 - 8.3e-22 77.1 0.6 8.3e-22 77.1 0.6 2.2 3 0 0 3 3 3 1 Bromodomain DUF953 PF06110.11 EFA81846.1 - 5.6e-19 67.9 0.0 6.2e-19 67.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 EFA81846.1 - 0.00027 20.9 0.3 0.00065 19.6 0.3 1.7 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EFA81846.1 - 0.019 14.7 0.3 0.025 14.3 0.3 1.5 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.6 EFA81846.1 - 0.13 12.4 0.1 0.4 10.9 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like Ank_2 PF12796.7 EFA81847.1 - 4.6e-25 88.0 0.5 0.00087 19.8 0.0 6.1 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81847.1 - 4.6e-20 71.4 8.7 0.012 15.9 0.0 9.6 5 4 5 10 10 10 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA81847.1 - 1.4e-18 67.0 11.1 0.0019 18.7 0.1 8.7 6 2 3 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81847.1 - 2.3e-14 52.1 6.7 1.4 9.7 0.0 12.9 12 3 3 15 15 15 2 Ankyrin repeat Ank PF00023.30 EFA81847.1 - 0.019 15.4 0.8 98 3.7 0.0 6.1 8 1 0 8 8 8 0 Ankyrin repeat DUF1843 PF08898.10 EFA81847.1 - 0.1 13.1 0.0 78 3.9 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) ABC_membrane PF00664.23 EFA81848.1 - 5.1e-108 360.9 24.6 2.8e-63 214.1 6.7 3.3 2 1 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EFA81848.1 - 1.3e-68 229.8 0.1 8.1e-35 120.3 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA81848.1 - 7.1e-18 64.9 0.1 1.3e-06 28.1 0.0 4.0 3 2 2 5 5 5 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EFA81848.1 - 2.2e-07 30.1 0.3 0.0057 15.5 0.0 2.6 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EFA81848.1 - 9.6e-06 25.3 1.6 0.041 13.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA81848.1 - 1.3e-05 25.6 0.0 0.062 13.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFA81848.1 - 3.3e-05 23.8 0.0 0.15 12.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 EFA81848.1 - 6.9e-05 23.0 3.6 0.23 11.7 0.3 4.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 EFA81848.1 - 0.00011 21.6 0.2 0.059 12.6 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin APS_kinase PF01583.20 EFA81848.1 - 0.00018 21.5 0.1 0.38 10.6 0.0 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_22 PF13401.6 EFA81848.1 - 0.00048 20.4 2.3 0.92 9.8 0.1 3.5 2 2 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFA81848.1 - 0.00061 19.6 0.4 0.8 9.4 0.0 3.2 2 2 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EFA81848.1 - 0.0013 18.7 1.2 11 5.7 0.0 4.1 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA81848.1 - 0.0041 16.9 6.0 0.094 12.4 0.1 2.9 3 0 0 3 3 3 2 AAA ATPase domain G-alpha PF00503.20 EFA81848.1 - 0.013 14.6 0.1 4.6 6.3 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.6 EFA81848.1 - 0.019 15.5 0.0 5.7 7.5 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFA81848.1 - 0.022 14.3 0.0 4 6.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region GPDPase_memb PF10110.9 EFA81848.1 - 0.023 13.5 0.2 0.023 13.5 0.2 2.1 2 0 0 2 2 2 0 Membrane domain of glycerophosphoryl diester phosphodiesterase ATP-synt_ab PF00006.25 EFA81848.1 - 0.038 13.6 0.5 13 5.3 0.0 3.2 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.14 EFA81848.1 - 0.091 12.8 0.2 29 4.6 0.0 3.7 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) PRK PF00485.18 EFA81848.1 - 0.11 12.2 0.0 5 6.8 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_25 PF13481.6 EFA81848.1 - 0.14 11.7 0.1 8.3 5.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain DUF2057 PF09829.9 EFA81848.1 - 0.14 12.3 0.2 25 5.0 0.0 2.8 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2057) DNA_pol_A_exo1 PF01612.20 EFA81849.1 - 2.1e-15 56.9 0.0 5.5e-15 55.5 0.0 1.7 2 0 0 2 2 2 1 3'-5' exonuclease Sigma_1_2 PF03084.14 EFA81849.1 - 0.17 11.2 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 Reoviral Sigma1/Sigma2 family Vps54_N PF10475.9 EFA81850.1 - 2.4e-67 227.3 12.8 4.6e-42 144.3 3.7 3.0 2 1 1 3 3 3 2 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EFA81850.1 - 5.7e-62 209.5 0.9 5.7e-62 209.5 0.9 3.2 4 1 0 4 4 4 1 Protein of unknown function C-terminus (DUF2451) Vps54 PF07928.12 EFA81850.1 - 0.0094 16.4 6.1 0.096 13.1 0.4 4.5 5 0 0 5 5 5 1 Vps54-like protein Pal1 PF08316.11 EFA81850.1 - 0.15 12.8 1.2 0.42 11.4 1.2 1.8 1 0 0 1 1 1 0 Pal1 cell morphology protein ESM4 PF15952.5 EFA81850.1 - 0.33 11.4 7.4 0.97 9.8 7.4 1.7 1 0 0 1 1 1 0 Enhancer of split M4 family PBP1_TM PF14812.6 EFA81850.1 - 1.1 9.6 9.2 2.4 8.6 9.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF913 PF06025.12 EFA81850.1 - 1.1 8.1 8.1 3.2 6.6 8.1 1.7 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Aminotran_1_2 PF00155.21 EFA81851.1 - 5.8e-68 229.7 0.0 6.5e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFA81851.1 - 1e-07 31.3 0.0 1.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFA81851.1 - 1.5e-05 23.7 0.0 2.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFA81851.1 - 0.00011 21.6 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EFA81851.1 - 0.0022 17.3 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.7 EFA81851.1 - 0.18 10.6 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase DEAD PF00270.29 EFA81852.1 - 4.1e-43 147.2 0.6 9.5e-43 146.0 0.6 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81852.1 - 2.5e-28 98.7 6.0 2.1e-27 95.6 0.3 3.6 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA81852.1 - 1.1e-07 32.1 0.0 1.1e-07 32.1 0.0 3.8 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DUF1664 PF07889.12 EFA81854.1 - 0.012 15.6 4.9 0.052 13.6 1.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SesA PF17107.5 EFA81854.1 - 0.045 13.9 1.2 0.17 12.1 1.0 2.0 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Baculo_PEP_C PF04513.12 EFA81854.1 - 0.067 13.2 9.8 0.078 13.0 6.3 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1451 PF07295.11 EFA81854.1 - 0.17 11.9 6.3 1.7 8.7 2.5 2.1 1 1 1 2 2 2 0 Zinc-ribbon containing domain MRP-S27 PF10037.9 EFA81854.1 - 0.21 10.4 7.5 0.25 10.1 7.5 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 RP-C_C PF11800.8 EFA81854.1 - 3.3 7.7 6.8 9.6 6.2 6.8 1.8 1 1 0 1 1 1 0 Replication protein C C-terminal region SAPIS-gp6 PF16722.5 EFA81854.1 - 4.8 7.6 12.2 39 4.8 8.0 2.9 2 1 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus DUF1748 PF08520.10 EFA81855.1 - 3.5e-09 36.4 0.0 4.8e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) DHHC PF01529.20 EFA81856.1 - 1.3e-12 48.0 34.5 3e-10 40.3 18.3 3.2 2 1 1 3 3 3 2 DHHC palmitoyltransferase PIP5K PF01504.18 EFA81856.1 - 0.032 13.5 0.3 0.05 12.8 0.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4834 PF16118.5 EFA81856.1 - 0.14 13.2 0.3 0.42 11.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Menin PF05053.13 EFA81856.1 - 0.24 9.7 0.9 0.28 9.5 0.9 1.1 1 0 0 1 1 1 0 Menin Tim44 PF04280.15 EFA81857.1 - 1.2e-05 25.5 0.0 2.6e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 EFA81857.1 - 0.0006 18.9 0.2 0.0009 18.4 0.2 1.2 1 0 0 1 1 1 1 MBA1-like protein DUF4317 PF14199.6 EFA81857.1 - 0.0019 17.4 0.6 0.0025 17.0 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4317) ABC_tran PF00005.27 EFA81858.1 - 0.055 14.0 0.2 0.11 13.0 0.2 1.5 1 0 0 1 1 1 0 ABC transporter Dicty_REP PF05086.12 EFA81858.1 - 0.074 11.0 0.1 0.093 10.7 0.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PRK PF00485.18 EFA81858.1 - 1.3 8.8 3.5 2.3 7.9 2.1 2.1 2 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family O-antigen_lig PF13425.6 EFA81860.1 - 0.014 14.3 0.2 0.014 14.2 0.2 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein HisK_sensor PF18698.1 EFA81860.1 - 0.26 11.7 4.8 0.39 11.1 4.8 1.3 1 1 0 1 1 1 0 Histidine kinase sensor domain NTP_transferase PF00483.23 EFA81861.1 - 4e-07 29.9 0.0 7e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase Baculo_p24 PF05073.12 EFA81861.1 - 0.00034 20.4 0.7 0.00058 19.7 0.1 1.7 2 0 0 2 2 2 1 Baculovirus P24 capsid protein Hexapep PF00132.24 EFA81861.1 - 0.001 18.7 10.8 0.081 12.7 2.4 3.4 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFA81861.1 - 0.039 14.3 0.0 0.06 13.7 0.0 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain CHASE9 PF17153.4 EFA81861.1 - 0.22 11.7 2.9 1.2 9.3 0.4 2.6 1 1 0 2 2 2 0 Periplasmic sensor domain, extracellular Hexapep_2 PF14602.6 EFA81861.1 - 1 9.2 12.2 4.8 7.0 1.1 3.7 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase NUDIX PF00293.28 EFA81862.1 - 2.1e-23 82.8 0.1 2.8e-23 82.4 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain AFG1_ATPase PF03969.16 EFA81863.1 - 3.1e-66 223.7 0.0 4.2e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 AFG1-like ATPase PEPcase PF00311.17 EFA81863.1 - 1.2e-08 33.6 1.0 1.7e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate carboxylase AAA_16 PF13191.6 EFA81863.1 - 0.00091 19.6 0.0 0.14 12.6 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain SAS4 PF15460.6 EFA81863.1 - 0.026 14.6 0.8 0.51 10.5 0.0 2.4 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 AAA PF00004.29 EFA81863.1 - 0.035 14.5 0.0 0.3 11.5 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 EFA81863.1 - 0.058 13.2 0.1 0.16 11.7 0.1 1.7 1 1 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 EFA81863.1 - 0.17 11.7 1.4 1.2 9.0 0.0 2.5 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea DUF3439 PF11921.8 EFA81863.1 - 0.65 10.0 6.4 1.1 9.2 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Cupin_8 PF13621.6 EFA81864.1 - 1e-67 228.5 0.0 1.3e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain cobW PF02492.19 EFA81865.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Agenet PF05641.12 EFA81866.1 - 0.073 13.6 0.2 1.6 9.2 0.1 2.3 2 0 0 2 2 2 0 Agenet domain P_gingi_FimA PF06321.11 EFA81866.1 - 0.1 12.7 6.7 0.58 10.3 0.9 2.2 2 0 0 2 2 2 0 Major fimbrial subunit protein (FimA) HSDR_N_2 PF13588.6 EFA81866.1 - 0.11 12.4 0.7 0.7 9.9 0.6 2.1 1 1 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF3439 PF11921.8 EFA81866.1 - 8 6.5 12.1 14 5.7 12.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Barstar PF01337.18 EFA81867.1 - 1.6e-14 53.7 0.2 2.1e-14 53.3 0.2 1.2 1 0 0 1 1 1 1 Barstar (barnase inhibitor) Resolvase PF00239.21 EFA81867.1 - 0.038 14.1 0.0 0.047 13.8 0.0 1.1 1 0 0 1 1 1 0 Resolvase, N terminal domain NAAA-beta PF15508.6 EFA81867.1 - 0.12 12.6 0.0 0.73 10.2 0.0 2.0 1 1 1 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase PEPcase PF00311.17 EFA81868.1 - 8.1e-272 903.9 0.0 1.1e-271 903.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 EFA81868.1 - 8.1e-05 21.3 0.0 0.00023 19.8 0.0 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate carboxylase MIP PF00230.20 EFA81869.1 - 5.2e-27 95.0 8.9 6e-27 94.8 8.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF3938 PF13074.6 EFA81869.1 - 0.028 14.7 0.3 0.066 13.5 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3938) TRAM_LAG1_CLN8 PF03798.16 EFA81871.1 - 1.4e-06 28.2 20.2 0.00081 19.2 0.7 3.5 2 1 2 4 4 4 3 TLC domain TIG PF01833.24 EFA81872.1 - 1.4e-09 37.8 13.0 0.00013 21.9 1.1 3.4 2 2 2 4 4 4 2 IPT/TIG domain SH3_6 PF12913.7 EFA81872.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) DUF485 PF04341.12 EFA81872.1 - 0.13 12.2 0.5 0.26 11.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Peptidase_M8 PF01457.16 EFA81873.1 - 1.2e-102 344.3 0.5 1.7e-102 343.8 0.5 1.1 1 0 0 1 1 1 1 Leishmanolysin TIG PF01833.24 EFA81873.1 - 5.3e-05 23.2 0.2 0.00018 21.5 0.2 2.0 1 0 0 1 1 1 1 IPT/TIG domain DUF4834 PF16118.5 EFA81873.1 - 0.024 15.6 2.5 7.7 7.5 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Tmemb_185A PF10269.9 EFA81873.1 - 0.035 13.8 0.1 0.062 13.0 0.1 1.4 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein DUF4079 PF13301.6 EFA81873.1 - 0.064 13.4 0.0 0.98 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) EphA2_TM PF14575.6 EFA81873.1 - 0.13 13.2 0.2 4.6 8.2 0.1 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain OSTbeta PF15048.6 EFA81873.1 - 0.25 11.5 0.6 3.2 7.9 0.1 2.2 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Peptidase_C26 PF07722.13 EFA81874.1 - 1.1e-19 71.1 0.0 2.7e-19 69.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 EFA81874.1 - 2.7e-09 37.0 0.0 4.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I PRP3 PF08572.10 EFA81874.1 - 0.29 10.9 0.0 0.36 10.5 0.0 1.1 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) YEATS PF03366.16 EFA81875.1 - 4.5e-28 97.0 0.2 1e-27 95.9 0.1 1.7 2 0 0 2 2 2 1 YEATS family FliD_N PF02465.18 EFA81875.1 - 0.17 12.6 20.4 0.042 14.5 16.3 1.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3439 PF11921.8 EFA81875.1 - 0.34 10.9 6.6 0.7 9.9 6.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Hydin_ADK PF17213.3 EFA81875.1 - 0.68 10.2 7.9 1 9.6 7.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain UAA PF08449.11 EFA81876.1 - 2.1e-66 224.2 21.0 2.7e-66 223.9 21.0 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFA81876.1 - 5.9e-11 42.7 21.6 9.4e-06 25.8 11.4 3.0 3 0 0 3 3 3 2 EamA-like transporter family TPT PF03151.16 EFA81876.1 - 0.0019 17.6 6.3 0.0019 17.6 6.3 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family Epimerase PF01370.21 EFA81877.1 - 2.1e-06 27.4 0.1 3.5e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA81877.1 - 0.00014 21.8 0.1 0.0021 18.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EFA81877.1 - 0.0012 18.4 0.3 0.0019 17.8 0.3 1.4 1 1 0 1 1 1 1 NmrA-like family Varsurf_PPLC PF03490.13 EFA81877.1 - 0.15 12.0 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 Variant-surface-glycoprotein phospholipase C Peptidase_M20 PF01546.28 EFA81878.1 - 2e-27 96.2 0.0 1.9e-14 53.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA81878.1 - 3.9e-12 46.0 0.0 7e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFA81878.1 - 0.037 13.7 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 Peptidase family M28 MRP-L20 PF12824.7 EFA81879.1 - 0.00065 19.9 0.3 0.00065 19.9 0.3 2.4 2 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 Myb_DNA-binding PF00249.31 EFA81880.1 - 1.2e-14 54.3 0.7 1e-07 32.0 0.0 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain CBM49 PF09478.10 EFA81881.1 - 1.5e-37 127.8 15.6 1.2e-19 70.4 1.8 2.5 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 DUF4106 PF13388.6 EFA81881.1 - 0.014 14.7 14.9 0.032 13.5 14.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) DNA_ligase_A_M PF01068.21 EFA81882.1 - 7.8e-52 175.9 0.4 7.8e-52 175.9 0.4 3.3 4 0 0 4 4 4 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFA81882.1 - 5.2e-40 137.6 0.7 5.2e-40 137.6 0.7 2.8 4 0 0 4 4 4 1 DNA ligase N terminus BRCT_2 PF16589.5 EFA81882.1 - 2.9e-17 62.8 6.2 1.2e-08 35.2 0.0 3.4 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 EFA81882.1 - 3.6e-17 62.8 0.0 1.1e-16 61.2 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_IV PF11411.8 EFA81882.1 - 2.6e-14 53.0 1.6 2.6e-14 53.0 1.6 1.9 2 0 0 2 2 2 1 DNA ligase IV BRCT PF00533.26 EFA81882.1 - 4.7e-13 49.3 3.8 1.2e-08 35.2 0.2 3.9 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 EFA81882.1 - 9.5e-09 35.8 0.3 9.5e-09 35.8 0.3 2.8 3 0 0 3 3 3 1 RNA ligase mRNA_cap_enzyme PF01331.19 EFA81882.1 - 2.3e-05 24.3 0.5 0.0011 18.8 0.5 2.9 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain Ribosomal_60s PF00428.19 EFA81882.1 - 0.069 13.8 1.3 0.17 12.5 1.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein CobT PF06213.12 EFA81882.1 - 3.4 7.0 14.8 7.5 5.9 14.8 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Aminopep PF10023.9 EFA81883.1 - 0.033 13.6 0.5 0.064 12.6 0.5 1.4 1 0 0 1 1 1 0 Putative aminopeptidase F-box-like PF12937.7 EFA81883.1 - 0.065 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 F-box-like Helicase_RecD PF05127.14 EFA81883.1 - 0.12 12.2 0.2 0.41 10.5 0.2 1.9 1 0 0 1 1 1 0 Helicase HeH PF12949.7 EFA81883.1 - 0.81 9.5 2.8 13 5.6 0.1 2.8 3 0 0 3 3 3 0 HeH/LEM domain 7TM_GPCR_Sru PF10322.9 EFA81884.1 - 0.029 13.7 0.1 0.049 12.9 0.1 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sru Methyltransf_2 PF00891.18 EFA81885.1 - 3.9e-18 65.5 0.0 5.6e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EFA81885.1 - 0.0016 18.3 0.1 0.011 15.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.9 EFA81885.1 - 0.0092 15.7 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase SgrR_N PF12793.7 EFA81885.1 - 0.022 15.0 0.0 0.059 13.6 0.0 1.7 1 0 0 1 1 1 0 Sugar transport-related sRNA regulator N-term HTH_27 PF13463.6 EFA81885.1 - 0.046 14.2 0.0 0.093 13.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Rrf2 PF02082.20 EFA81885.1 - 0.073 13.4 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator LRR_6 PF13516.6 EFA81886.1 - 4.9e-30 101.0 36.1 3.4e-06 26.7 0.4 11.0 11 0 0 11 11 11 8 Leucine Rich repeat LRR_1 PF00560.33 EFA81886.1 - 0.00011 22.2 11.7 2.6 8.9 0.1 7.9 9 1 0 9 9 9 1 Leucine Rich Repeat F-box-like PF12937.7 EFA81886.1 - 0.071 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 EFA81886.1 - 0.097 13.1 32.4 0.15 12.5 1.5 7.2 5 3 3 8 8 8 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA81886.1 - 5.4 6.9 32.7 10 5.9 1.4 8.1 2 2 6 8 8 8 0 Leucine rich repeat Actin PF00022.19 EFA81888.1 - 4.8e-152 506.3 0.0 1.5e-151 504.6 0.0 1.6 1 1 0 1 1 1 1 Actin Ank_2 PF12796.7 EFA81889.1 - 1.1e-29 102.8 2.1 6.3e-08 33.1 0.1 6.0 4 2 3 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81889.1 - 5.8e-29 100.1 6.8 7.7e-07 29.5 0.0 8.6 4 3 6 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81889.1 - 4.1e-26 90.7 6.9 0.00019 21.7 0.4 9.8 4 3 6 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81889.1 - 4e-19 66.7 0.4 2.7 8.8 0.0 11.6 11 1 2 13 13 12 3 Ankyrin repeat VHP PF02209.19 EFA81889.1 - 3.8e-12 46.1 1.4 6.6e-12 45.3 1.4 1.4 1 0 0 1 1 1 1 Villin headpiece domain DUF3447 PF11929.8 EFA81889.1 - 3.8e-05 23.5 1.7 11 6.0 0.0 5.3 4 2 1 5 5 5 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA81889.1 - 0.007 16.8 0.1 1.5e+02 3.1 0.0 5.9 4 2 3 7 7 6 0 Ankyrin repeat DUF4411 PF14367.6 EFA81889.1 - 0.011 15.6 2.4 3.7 7.4 0.0 4.0 3 1 2 5 5 5 0 Domain of unknown function (DUF4411) HOIP-UBA PF16678.5 EFA81889.1 - 0.03 14.3 1.0 24 4.9 0.0 3.9 4 0 0 4 4 4 0 HOIP UBA domain pair FBD PF08387.10 EFA81889.1 - 0.086 12.7 0.7 56 3.7 0.0 4.1 5 0 0 5 5 4 0 FBD DEP PF00610.21 EFA81889.1 - 0.93 9.6 4.7 1e+02 3.1 0.0 4.8 5 1 1 6 6 6 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) tRNA-synt_1c PF00749.21 EFA81890.1 - 3.1e-96 322.0 0.2 5.3e-96 321.2 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFA81890.1 - 6.5e-34 117.3 0.4 6.5e-34 117.3 0.4 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C PF00043.25 EFA81890.1 - 2.4e-06 27.7 0.0 7.4e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA81890.1 - 7.9e-05 22.8 0.2 0.00087 19.4 0.1 2.7 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA81890.1 - 0.016 15.2 0.0 0.041 13.9 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SH3_2 PF07653.17 EFA81891.1 - 4.4e-10 39.1 0.0 6.5e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFA81891.1 - 2.5e-08 33.6 0.0 5e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA81891.1 - 1.4e-05 24.5 0.1 1.4e-05 24.5 0.1 1.7 2 0 0 2 2 2 1 SH3 domain adh_short PF00106.25 EFA81892.1 - 6.3e-52 175.9 0.6 8.1e-52 175.5 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA81892.1 - 1.2e-33 116.6 0.1 1.6e-33 116.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA81892.1 - 7.7e-11 42.2 1.8 2.8e-10 40.4 1.8 1.8 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFA81892.1 - 0.00035 19.8 0.1 0.00046 19.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Pyr_redox_2 PF07992.14 EFA81892.1 - 0.00078 18.8 0.1 0.0012 18.2 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EFA81892.1 - 0.0024 17.3 0.0 0.0037 16.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 EFA81892.1 - 0.0038 17.9 0.1 0.0089 16.7 0.1 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Epimerase PF01370.21 EFA81892.1 - 0.0061 16.0 0.1 0.087 12.3 0.0 2.4 2 1 1 3 3 3 1 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 EFA81892.1 - 0.014 16.0 0.1 0.029 14.9 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RmlD_sub_bind PF04321.17 EFA81892.1 - 0.024 13.7 0.3 0.04 13.0 0.3 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain 3HCDH_N PF02737.18 EFA81892.1 - 0.076 12.9 2.1 0.1 12.4 1.1 1.8 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FNIP PF05725.12 EFA81893.1 - 0.13 12.4 4.1 4.4 7.5 1.1 4.1 2 1 0 2 2 2 0 FNIP Repeat DUF3557 PF12078.8 EFA81893.1 - 0.18 11.7 7.1 0.045 13.7 2.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3557) UPF0086 PF01868.16 EFA81896.1 - 4.8e-15 55.2 0.1 8.8e-15 54.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Methyltransf_15 PF09445.10 EFA81897.1 - 4e-41 140.3 0.0 9.5e-41 139.1 0.0 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EFA81897.1 - 4.4e-06 27.3 0.0 1e-05 26.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EFA81897.1 - 4.7e-06 26.4 0.1 1.3e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_5 PF01795.19 EFA81897.1 - 0.00088 18.9 0.7 0.0016 18.0 0.0 1.7 2 0 0 2 2 2 1 MraW methylase family Methyltransf_31 PF13847.6 EFA81897.1 - 0.002 18.0 2.0 0.0097 15.7 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 EFA81897.1 - 0.0059 16.3 0.7 0.029 14.0 0.1 2.3 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 EFA81897.1 - 0.0069 17.0 0.0 0.018 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA81897.1 - 0.026 14.1 0.1 0.075 12.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_18 PF12847.7 EFA81897.1 - 0.099 12.6 0.1 0.099 12.6 0.1 2.1 3 0 0 3 3 3 0 Methyltransferase domain CDO_I PF05995.12 EFA81898.1 - 8.7e-25 87.0 0.0 1.6e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Cysteine dioxygenase type I Nucleoporin_C PF03177.14 EFA81899.1 - 8.2e-16 57.9 22.6 8.2e-16 57.9 22.6 2.4 2 1 0 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal Epimerase PF01370.21 EFA81899.1 - 6.3e-14 52.0 0.0 1.5e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA81899.1 - 2e-09 37.0 0.0 3.7e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EFA81899.1 - 0.00016 21.2 0.0 0.0021 17.5 0.0 2.2 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFA81899.1 - 0.0039 16.4 0.1 0.013 14.7 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein bZIP_1 PF00170.21 EFA81900.1 - 7.9e-07 29.1 14.5 0.053 13.6 0.7 3.5 3 0 0 3 3 3 3 bZIP transcription factor FlaC_arch PF05377.11 EFA81900.1 - 0.00013 22.3 13.4 0.048 14.1 0.9 3.6 2 1 1 3 3 3 2 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.8 EFA81900.1 - 0.0094 15.9 16.6 0.22 11.5 2.9 3.3 3 0 0 3 3 3 2 TATA element modulatory factor 1 DNA binding Rho_Binding PF08912.11 EFA81900.1 - 0.063 14.1 2.9 0.063 14.1 2.9 3.8 3 1 0 3 3 3 0 Rho Binding DUF5305 PF17231.2 EFA81900.1 - 0.079 12.4 3.3 0.93 8.8 1.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5305) GAS PF13851.6 EFA81900.1 - 0.11 11.8 27.2 0.15 11.4 6.0 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3877 PF12993.7 EFA81900.1 - 0.48 10.3 4.0 0.64 9.9 3.6 1.4 1 1 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) HALZ PF02183.18 EFA81900.1 - 0.7 10.2 14.5 0.47 10.7 0.8 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper XhlA PF10779.9 EFA81900.1 - 1.2 9.4 11.4 2.2 8.5 1.9 2.8 3 0 0 3 3 2 0 Haemolysin XhlA DivIVA PF05103.13 EFA81900.1 - 1.6 8.8 16.6 1.2 9.3 2.2 2.8 2 1 0 2 2 2 0 DivIVA protein SlyX PF04102.12 EFA81900.1 - 1.7 9.3 19.4 3.5 8.3 0.9 3.7 2 1 1 3 3 3 0 SlyX bZIP_2 PF07716.15 EFA81900.1 - 2.2 8.4 26.0 0.83 9.8 2.3 4.2 4 1 0 4 4 4 0 Basic region leucine zipper PRKG1_interact PF15898.5 EFA81900.1 - 2.3 9.2 26.1 3.3 8.7 4.6 3.2 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain RPW8 PF05659.11 EFA81900.1 - 2.7 7.7 8.8 6.8 6.4 1.8 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Prefoldin PF02996.17 EFA81900.1 - 3.1 7.8 14.9 4.8 7.1 4.3 3.2 3 0 0 3 3 3 0 Prefoldin subunit LRRFIP PF09738.9 EFA81900.1 - 3.4 7.0 24.6 0.63 9.5 4.7 2.7 1 1 1 2 2 2 0 LRRFIP family FUSC PF04632.12 EFA81900.1 - 3.7 6.0 5.3 4.4 5.7 5.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family HlyD_2 PF12700.7 EFA81900.1 - 4.3 6.0 11.8 7 5.3 11.4 1.5 1 1 0 1 1 1 0 HlyD family secretion protein Csm1_N PF18504.1 EFA81900.1 - 4.8 7.6 26.9 9.1 6.7 5.4 4.4 2 1 2 4 4 4 0 Csm1 N-terminal domain Cep57_CLD_2 PF14197.6 EFA81900.1 - 5 7.3 19.6 1.4 9.0 8.3 2.8 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 BLOC1_2 PF10046.9 EFA81900.1 - 5.4 7.4 15.3 12 6.2 3.0 3.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0242 PF06785.11 EFA81900.1 - 6.3 6.9 30.2 1.4 9.0 11.8 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 EFA81900.1 - 6.6 7.4 22.5 67 4.2 9.8 3.2 1 1 1 2 2 2 0 Initiation control protein YabA G10 PF01125.17 EFA81900.1 - 6.6 6.5 8.5 3.6 7.3 1.0 2.2 1 1 1 2 2 2 0 G10 protein Cnn_1N PF07989.11 EFA81900.1 - 7.4 6.8 20.5 77 3.6 4.1 3.1 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 EFA81900.1 - 7.9 6.3 21.3 10 5.9 1.7 3.5 2 1 1 3 3 3 0 Septum formation initiator Phosphodiest PF01663.22 EFA81901.1 - 4.2e-68 230.5 5.9 4.3e-67 227.2 5.9 2.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFA81901.1 - 5.6e-06 26.0 9.2 6.5e-05 22.5 0.4 4.1 3 1 0 3 3 3 2 Sulfatase DUF4083 PF13314.6 EFA81901.1 - 0.021 14.8 0.3 0.095 12.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) DUF1501 PF07394.12 EFA81901.1 - 0.072 12.1 0.0 0.072 12.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) PfkB PF00294.24 EFA81902.1 - 3.4e-65 220.3 0.7 4e-65 220.1 0.7 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EFA81902.1 - 0.027 13.8 0.0 0.063 12.6 0.0 1.6 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase SprA-related PF12118.8 EFA81903.1 - 0.00034 19.9 18.8 0.0004 19.6 18.8 1.1 1 0 0 1 1 1 1 SprA-related family AF-4 PF05110.13 EFA81903.1 - 0.028 12.5 31.3 0.026 12.6 31.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein VIR_N PF15912.5 EFA81903.1 - 0.051 13.2 18.9 0.069 12.7 18.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Borrelia_P83 PF05262.11 EFA81903.1 - 0.052 12.0 30.9 0.05 12.1 30.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SAPS PF04499.15 EFA81903.1 - 0.18 10.5 15.5 0.19 10.5 15.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC27 PF09507.10 EFA81903.1 - 0.5 9.7 46.3 0.57 9.5 46.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Endostatin PF06482.11 EFA81903.1 - 3.4 7.1 13.0 4.8 6.6 13.0 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin IPK PF03770.16 EFA81904.1 - 4.8e-43 147.3 0.7 5.3e-42 143.9 0.7 2.3 1 1 0 1 1 1 1 Inositol polyphosphate kinase FAD_binding_2 PF00890.24 EFA81905.1 - 3.1e-08 33.1 0.4 2.5e-05 23.6 1.3 2.2 1 1 1 2 2 2 2 FAD binding domain DAO PF01266.24 EFA81905.1 - 1.2e-07 31.7 0.0 5.2e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EFA81905.1 - 1.2e-06 28.0 0.0 3.7e-06 26.4 0.1 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EFA81905.1 - 1.9e-06 28.0 0.0 5.9e-06 26.4 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFA81905.1 - 2.4e-05 24.4 0.1 5.5e-05 23.2 0.1 1.7 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EFA81905.1 - 4.9e-05 22.2 0.2 8.3e-05 21.5 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EFA81905.1 - 5.2e-05 23.7 0.1 0.22 12.1 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA81905.1 - 7.8e-05 22.0 0.1 0.00022 20.6 0.2 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA81905.1 - 0.0002 20.6 0.3 0.0003 20.0 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EFA81905.1 - 0.00098 18.5 0.1 0.0014 17.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFA81905.1 - 0.0017 17.6 0.1 0.0027 17.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EFA81905.1 - 0.0018 17.2 0.2 0.088 11.6 0.3 2.3 2 0 0 2 2 2 1 Tryptophan halogenase K_oxygenase PF13434.6 EFA81905.1 - 0.0035 16.6 0.0 0.0052 16.0 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EFA81905.1 - 0.0051 16.2 0.1 0.0081 15.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase PRMT5 PF05185.16 EFA81905.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase GIDA PF01134.22 EFA81905.1 - 0.19 10.8 0.2 0.28 10.2 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Tom7 PF08038.12 EFA81905.1 - 0.43 10.3 1.4 1 9.1 1.4 1.6 1 0 0 1 1 1 0 TOM7 family PPR_3 PF13812.6 EFA81906.1 - 2.8e-08 33.7 0.2 9e-08 32.1 0.2 1.9 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EFA81906.1 - 0.00025 21.2 0.0 0.0006 20.0 0.0 1.7 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 EFA81906.1 - 0.067 13.5 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 PPR repeat Integrase_H2C2 PF17921.1 EFA81907.1 - 2.7e-07 30.6 1.6 4.4e-07 29.9 0.8 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain FliG_M PF14841.6 EFA81907.1 - 0.081 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 FliG middle domain DNA_ligase_A_N PF04675.14 EFA81907.1 - 0.084 13.2 3.2 0.059 13.7 1.0 1.8 2 0 0 2 2 2 0 DNA ligase N terminus zf-H2C2 PF09337.10 EFA81907.1 - 0.16 12.2 0.1 0.33 11.2 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger Occludin_ELL PF07303.13 EFA81907.1 - 3.1 8.6 11.6 0.089 13.5 2.5 2.8 3 0 0 3 3 3 0 Occludin homology domain DUF3450 PF11932.8 EFA81907.1 - 4.3 6.6 10.1 0.067 12.5 2.9 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) SR-25 PF10500.9 EFA81907.1 - 5.3 6.6 30.2 3 7.4 8.9 2.7 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein TIG PF01833.24 EFA81908.1 - 1.1e-74 246.5 177.2 3.3e-12 46.3 6.1 19.7 14 3 3 17 17 17 12 IPT/TIG domain DNase_II PF03265.15 EFA81908.1 - 2.7e-37 128.8 0.8 9.3e-37 127.0 0.8 2.1 1 0 0 1 1 1 1 Deoxyribonuclease II G_glu_transpept PF01019.21 EFA81909.1 - 9.3e-76 255.6 0.0 1.4e-46 159.4 0.0 2.0 2 0 0 2 2 2 2 Gamma-glutamyltranspeptidase EamA PF00892.20 EFA81910.1 - 4.1e-15 56.2 39.7 7.5e-07 29.4 17.5 3.1 3 0 0 3 3 3 3 EamA-like transporter family SLC35F PF06027.12 EFA81910.1 - 1e-05 25.2 18.8 1e-05 25.2 18.8 1.5 2 0 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 EFA81910.1 - 3.1e-05 23.3 5.2 3.1e-05 23.3 5.2 2.7 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport TPT PF03151.16 EFA81910.1 - 0.0024 17.3 13.4 0.0024 17.3 13.4 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.6 EFA81910.1 - 0.0073 15.9 11.9 0.01 15.5 9.9 2.2 2 1 1 3 3 3 1 Putative multidrug resistance efflux transporter Scs3p PF10261.9 EFA81910.1 - 0.063 12.8 0.0 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2976 PF11190.8 EFA81910.1 - 0.45 10.3 4.5 12 5.7 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) WD40 PF00400.32 EFA81911.1 - 2e-30 104.3 14.6 8.8e-07 29.5 0.2 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Alpha_kinase PF02816.18 EFA81911.1 - 1.2e-18 67.9 0.3 3.7e-18 66.3 0.1 2.0 1 1 1 2 2 2 1 Alpha-kinase family Nup160 PF11715.8 EFA81911.1 - 1.2e-06 27.5 6.4 0.098 11.3 0.0 4.7 2 2 3 5 5 5 4 Nucleoporin Nup120/160 YmzC PF14157.6 EFA81911.1 - 0.00022 21.3 0.2 0.21 11.7 0.0 4.2 4 0 0 4 4 4 1 YmzC-like protein WD40_like PF17005.5 EFA81911.1 - 0.0015 17.9 1.6 0.014 14.7 0.7 2.6 1 1 1 2 2 2 1 WD40-like domain HPS3_N PF14761.6 EFA81911.1 - 0.035 13.6 0.0 32 3.9 0.0 3.2 1 1 2 3 3 3 0 Hermansky-Pudlak syndrome 3 DUF1353 PF07087.11 EFA81911.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) Ogr_Delta PF04606.12 EFA81912.1 - 0.13 12.2 1.0 0.23 11.5 1.0 1.4 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger Ion_trans PF00520.31 EFA81913.1 - 1.6e-38 132.3 64.5 1.7e-24 86.4 33.2 3.0 3 0 0 3 3 3 2 Ion transport protein EF-hand_1 PF00036.32 EFA81913.1 - 4.6e-06 25.8 0.1 0.0091 15.5 0.1 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA81913.1 - 5.8e-06 25.8 0.3 0.088 12.8 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain TFIIA PF03153.13 EFA81913.1 - 4.2e-05 23.7 33.1 4.2e-05 23.7 33.1 4.6 3 2 1 4 4 4 1 Transcription factor IIA, alpha/beta subunit EF-hand_7 PF13499.6 EFA81913.1 - 5.1e-05 23.6 0.0 0.00016 22.1 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EFA81913.1 - 0.0022 17.8 0.3 0.0099 15.7 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair Myb_DNA-binding PF00249.31 EFA81915.1 - 9.8e-10 38.5 0.2 2.1e-09 37.4 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain G_glu_transpept PF01019.21 EFA81916.1 - 4.8e-126 421.5 0.0 5.6e-126 421.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase CRAL_TRIO PF00650.20 EFA81917.1 - 9.6e-41 139.1 0.1 1.2e-40 138.8 0.1 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFA81917.1 - 7.4e-06 26.2 0.1 1.1e-05 25.6 0.1 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Epimerase PF01370.21 EFA81918.1 - 5.5e-12 45.7 0.1 7.1e-05 22.4 0.0 2.4 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFA81918.1 - 6.2e-07 29.2 0.1 1.5e-06 27.9 0.1 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EFA81918.1 - 8.9e-06 25.7 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFA81918.1 - 0.00043 19.8 0.1 0.001 18.6 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase 3HCDH_N PF02737.18 EFA81918.1 - 0.0023 17.9 0.0 0.07 13.0 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EFA81918.1 - 0.0034 16.8 0.0 0.36 10.2 0.0 2.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 EFA81918.1 - 0.0088 16.0 0.1 0.05 13.6 0.0 2.1 2 1 0 2 2 2 1 Zinc-binding dehydrogenase DapB_N PF01113.20 EFA81918.1 - 0.018 15.2 0.2 0.033 14.3 0.2 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 EFA81918.1 - 0.02 14.0 0.0 0.047 12.8 0.0 1.9 1 1 0 1 1 1 0 RmlD substrate binding domain DFP PF04127.15 EFA81918.1 - 0.024 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_2 PF03446.15 EFA81918.1 - 0.03 14.5 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 EFA81918.1 - 0.052 13.8 0.1 0.094 13.0 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Glu_dehyd_C PF16912.5 EFA81918.1 - 0.092 12.2 0.0 0.17 11.3 0.0 1.5 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus F420_oxidored PF03807.17 EFA81918.1 - 0.11 13.0 0.1 0.28 11.8 0.1 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DXP_reductoisom PF02670.16 EFA81918.1 - 0.14 12.9 0.1 0.71 10.6 0.0 2.1 1 1 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DEAD PF00270.29 EFA81919.1 - 6.3e-35 120.5 0.1 6.3e-35 120.5 0.1 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA81919.1 - 5.1e-28 97.6 3.5 8.3e-28 97.0 0.2 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF2052 PF09747.9 EFA81919.1 - 0.0093 16.1 4.3 0.0093 16.1 4.3 5.6 4 1 1 5 5 5 1 Coiled-coil domain containing protein (DUF2052) Peroxin-13_N PF04088.13 EFA81919.1 - 0.031 14.6 0.0 0.031 14.6 0.0 5.0 4 1 0 4 4 4 0 Peroxin 13, N-terminal region SID-1_RNA_chan PF13965.6 EFA81919.1 - 1.9 6.8 14.1 3.5 5.9 0.1 2.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PWWP PF00855.17 EFA81920.1 - 1.7e-13 50.7 0.6 1.7e-13 50.7 0.6 3.2 4 0 0 4 4 4 1 PWWP domain UQ_con PF00179.26 EFA81921.1 - 1.4e-35 122.0 0.0 2e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme FAM199X PF15814.5 EFA81921.1 - 0.12 11.4 8.8 0.16 11.0 8.8 1.1 1 0 0 1 1 1 0 Protein family FAM199X Med3 PF11593.8 EFA81921.1 - 2.5 7.2 15.7 3.3 6.8 15.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Herpes_capsid PF06112.11 EFA81921.1 - 5.1 7.1 14.1 7.5 6.6 14.1 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SR-25 PF10500.9 EFA81921.1 - 6.6 6.3 17.2 9.6 5.7 17.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein adh_short PF00106.25 EFA81922.1 - 2e-48 164.4 0.1 2.9e-48 163.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA81922.1 - 1e-36 126.7 0.0 1.3e-36 126.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA81922.1 - 2.9e-12 46.9 0.0 4.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA81922.1 - 0.00018 21.0 0.2 0.00087 18.8 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFA81922.1 - 0.0052 16.2 0.1 0.018 14.4 0.1 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 EFA81922.1 - 0.042 13.8 0.1 0.09 12.8 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Glutaredoxin PF00462.24 EFA81923.1 - 0.00096 19.3 0.0 0.0019 18.4 0.0 1.6 1 1 0 1 1 1 1 Glutaredoxin MctB PF11382.8 EFA81923.1 - 0.2 11.3 0.0 0.26 11.0 0.0 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB Methyltransf_2 PF00891.18 EFA81924.1 - 1.5e-37 129.0 0.0 1.8e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain RINT1_TIP1 PF04437.13 EFA81924.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 RINT-1 / TIP-1 family Rrf2 PF02082.20 EFA81924.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator DUF1415 PF07209.12 EFA81925.1 - 0.0058 16.4 0.2 0.0058 16.4 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1415) IFT20 PF14931.6 EFA81925.1 - 0.28 11.4 10.1 0.2 11.8 5.3 2.7 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 DUF5423 PF17461.2 EFA81925.1 - 3 6.6 10.0 4.5 6.0 10.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) DUF4446 PF14584.6 EFA81925.1 - 5.8 6.9 11.0 0.19 11.7 0.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) Presenilin PF01080.17 EFA81925.1 - 7.9 5.1 6.7 12 4.5 6.7 1.3 1 0 0 1 1 1 0 Presenilin RWP-RK PF02042.15 EFA81927.1 - 6.1e-06 26.1 0.1 1.3e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 RWP-RK domain HTH_psq PF05225.16 EFA81927.1 - 0.024 14.4 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_8 PF02954.19 EFA81927.1 - 0.037 13.8 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family ArfGap PF01412.18 EFA81928.1 - 4.2e-29 101.0 0.2 4.2e-29 101.0 0.2 3.8 4 0 0 4 4 4 1 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.12 EFA81928.1 - 0.012 15.1 1.3 0.012 15.1 1.3 3.2 3 1 0 3 3 3 0 TFIIB zinc-binding zf-TRAF PF02176.18 EFA81928.1 - 0.029 15.1 7.5 0.089 13.5 4.4 2.4 1 1 1 2 2 2 0 TRAF-type zinc finger zf_UBZ PF18439.1 EFA81928.1 - 1.5 8.5 10.2 17 5.1 0.0 5.2 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger C1_1 PF00130.22 EFA81928.1 - 1.7 8.6 15.0 0.7 9.8 0.2 3.1 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Snf7 PF03357.21 EFA81929.1 - 2.3e-36 125.0 21.2 3e-36 124.6 21.2 1.2 1 0 0 1 1 1 1 Snf7 GhoS PF11080.8 EFA81929.1 - 0.036 14.1 1.1 0.069 13.1 0.2 2.0 2 0 0 2 2 2 0 Endoribonuclease GhoS DUF5082 PF16888.5 EFA81929.1 - 1.1 9.6 13.7 0.62 10.3 8.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) HrpB7 PF09486.10 EFA81929.1 - 3.6 7.9 12.0 0.31 11.4 1.8 2.7 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) CENP-Q PF13094.6 EFA81929.1 - 5.6 7.1 22.0 0.038 14.2 11.6 2.3 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit adh_short PF00106.25 EFA81930.1 - 4.9e-49 166.5 0.1 6.2e-49 166.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA81930.1 - 1.5e-37 129.4 0.0 1.9e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA81930.1 - 8.6e-13 48.6 0.0 1.3e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA81930.1 - 0.00017 21.1 0.1 0.00061 19.3 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA81930.1 - 0.025 13.7 0.1 0.037 13.1 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain DUF1776 PF08643.10 EFA81930.1 - 0.086 12.2 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Acetyltransf_3 PF13302.7 EFA81931.1 - 1.3e-16 61.5 0.0 1.5e-16 61.3 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA81931.1 - 0.0041 17.1 0.0 0.0078 16.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EFA81931.1 - 0.098 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase_Tyr PF07714.17 EFA81932.1 - 1.4e-30 106.5 0.0 3e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA81932.1 - 1.3e-23 83.7 0.0 4.4e-23 82.0 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Acetyltransf_1 PF00583.25 EFA81932.1 - 2.4e-09 37.5 0.0 5.6e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA81932.1 - 3.1e-08 33.9 0.0 7.1e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA81932.1 - 4.6e-07 29.8 0.0 1.2e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Arm PF00514.23 EFA81932.1 - 3.1e-05 23.8 0.2 0.0027 17.7 0.1 3.5 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat FR47 PF08445.10 EFA81932.1 - 0.0001 22.2 0.0 0.00036 20.4 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein HEAT_2 PF13646.6 EFA81932.1 - 0.024 15.0 0.0 0.15 12.4 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats PB1 PF00564.24 EFA81933.1 - 3.9e-14 52.3 0.0 6.6e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Pkinase PF00069.25 EFA81934.1 - 7.5e-46 156.6 0.1 2.1e-45 155.1 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81934.1 - 3.4e-21 75.7 0.0 1.4e-20 73.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase GREB1 PF15782.5 EFA81934.1 - 0.11 9.6 11.6 0.15 9.2 11.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4746 PF15928.5 EFA81934.1 - 0.47 9.8 6.8 0.75 9.2 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Lin-8 PF03353.15 EFA81934.1 - 3.8 7.0 12.9 6.9 6.1 12.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Pkinase_fungal PF17667.1 EFA81934.1 - 4.7 5.9 5.6 17 4.1 0.2 2.2 2 0 0 2 2 2 0 Fungal protein kinase SRP-alpha_N PF04086.13 EFA81934.1 - 6.7 6.5 14.0 13 5.6 14.0 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ank_4 PF13637.6 EFA81936.1 - 2.2e-28 98.2 3.7 0.00099 19.6 0.0 10.8 9 2 3 12 12 12 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA81936.1 - 1.2e-26 93.1 3.7 3.9e-05 24.2 0.1 6.8 2 2 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA81936.1 - 2e-18 66.2 4.3 1 9.7 0.0 10.7 5 4 5 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81936.1 - 1.7e-12 46.3 0.9 20 6.2 0.0 11.2 12 1 1 13 13 13 1 Ankyrin repeat DUF1843 PF08898.10 EFA81936.1 - 0.0042 17.6 0.0 1 9.9 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF1843) CCDC23 PF15674.5 EFA81937.1 - 0.014 15.3 0.6 0.031 14.3 0.6 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 23 Colicin_Pyocin PF01320.18 EFA81937.1 - 0.071 13.2 0.4 2.5 8.3 0.0 2.9 3 0 0 3 3 3 0 Colicin immunity protein / pyocin immunity protein Sel1 PF08238.12 EFA81938.1 - 2.8e-43 145.4 44.8 0.00013 22.5 0.0 11.7 11 0 0 11 11 11 11 Sel1 repeat Dapper PF15268.6 EFA81938.1 - 0.05 12.5 20.0 0.069 12.0 20.0 1.2 1 0 0 1 1 1 0 Dapper Mem_trans PF03547.18 EFA81938.1 - 0.18 10.2 0.3 0.31 9.4 0.1 1.7 2 0 0 2 2 2 0 Membrane transport protein Selenoprotein_S PF06936.11 EFA81938.1 - 5 6.9 20.9 14 5.4 20.9 1.7 1 0 0 1 1 1 0 Selenoprotein S (SelS) Ndc1_Nup PF09531.10 EFA81938.1 - 8.4 5.0 15.7 13 4.3 15.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MFS_Mycoplasma PF07672.13 EFA81938.1 - 9.7 5.4 6.8 1.5 8.0 2.3 2.0 2 0 0 2 2 2 0 Mycoplasma MFS transporter PP2C PF00481.21 EFA81940.1 - 8.8e-50 169.7 0.0 8.8e-50 169.7 0.0 2.6 3 1 0 3 3 3 1 Protein phosphatase 2C Thioesterase PF00975.20 EFA81940.1 - 0.0016 18.6 0.8 0.0031 17.6 0.8 1.5 1 0 0 1 1 1 1 Thioesterase domain LMBR1 PF04791.16 EFA81940.1 - 0.0016 17.5 4.6 0.0016 17.5 4.6 1.9 2 0 0 2 2 2 1 LMBR1-like membrane protein SpoIIE PF07228.12 EFA81940.1 - 0.0016 18.4 0.0 0.49 10.3 0.0 2.6 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PrgI PF12666.7 EFA81940.1 - 0.068 13.9 2.6 0.14 12.9 2.6 1.5 1 0 0 1 1 1 0 PrgI family protein DUF16 PF01519.16 EFA81940.1 - 3 8.4 14.2 0.51 10.9 4.5 2.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 Atg14 PF10186.9 EFA81940.1 - 4 6.4 21.3 2.5 7.1 18.9 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 VSG_B PF13206.6 EFA81940.1 - 4.1 6.6 14.5 6.9 5.8 14.5 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain Thioredoxin PF00085.20 EFA81941.1 - 0.036 14.0 0.1 0.086 12.8 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin TORC_C PF12886.7 EFA81943.1 - 0.2 12.3 1.9 1.5 9.4 0.7 2.9 2 1 1 3 3 3 0 Transducer of regulated CREB activity, C terminus TPALS PF18178.1 EFA81943.1 - 3.2 7.1 9.6 0.27 10.6 2.6 2.3 1 1 0 2 2 2 0 TIR- and PNP-associating SLOG family Pkinase PF00069.25 EFA81944.1 - 7.6e-72 241.8 0.0 1.2e-71 241.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA81944.1 - 8e-49 166.2 0.0 1.2e-48 165.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA81944.1 - 1.4e-05 24.5 0.0 2.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFA81944.1 - 0.00095 18.0 0.0 0.00095 18.0 0.0 2.2 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFA81944.1 - 0.043 12.8 0.0 0.23 10.3 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain FSA_C PF10479.9 EFA81944.1 - 1.9 6.5 13.4 2.7 6.0 13.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CNDH2_C PF16858.5 EFA81944.1 - 5.2 6.8 9.8 2.9 7.7 0.8 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term GATA PF00320.27 EFA81945.1 - 0.0028 17.2 1.7 0.0055 16.3 1.7 1.6 1 0 0 1 1 1 1 GATA zinc finger CX9C PF16860.5 EFA81945.1 - 0.016 15.2 0.2 0.037 14.0 0.2 1.6 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, AT_hook PF02178.19 EFA81945.1 - 0.49 10.4 7.4 0.82 9.8 7.4 1.4 1 0 0 1 1 1 0 AT hook motif VWA PF00092.28 EFA81946.1 - 2.6e-12 47.3 0.0 4.3e-11 43.4 0.0 3.2 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA81946.1 - 8e-06 26.5 0.0 9.4e-05 23.0 0.0 3.1 1 0 0 1 1 1 1 von Willebrand factor type A domain F-box-like PF12937.7 EFA81946.1 - 0.00086 19.2 0.2 0.0029 17.4 0.2 1.8 1 0 0 1 1 1 1 F-box-like Med25_VWA PF11265.8 EFA81946.1 - 0.0049 16.7 0.0 0.016 15.1 0.0 1.8 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A F-box PF00646.33 EFA81946.1 - 0.15 11.9 1.2 0.56 10.2 0.2 2.5 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EFA81947.1 - 2.8e-07 30.3 0.7 2.8e-07 30.3 0.7 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA81947.1 - 5.7e-05 22.9 0.8 0.00024 20.9 0.8 2.1 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFA81947.1 - 0.0034 17.3 0.1 0.0085 16.0 0.1 1.7 1 0 0 1 1 1 1 F-box Spt20 PF12090.8 EFA81948.1 - 0.008 15.8 17.8 0.01 15.4 17.8 1.2 1 0 0 1 1 1 1 Spt20 family DUF1827 PF08860.10 EFA81948.1 - 0.024 14.9 1.6 0.024 14.9 1.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1827) MtlR PF05068.12 EFA81948.1 - 0.15 12.1 4.3 0.21 11.6 4.3 1.2 1 0 0 1 1 1 0 Mannitol repressor CNOT1_HEAT PF16418.5 EFA81948.1 - 0.43 10.7 6.6 0.66 10.0 5.6 1.7 1 1 1 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat ABC2_membrane_3 PF12698.7 EFA81948.1 - 4.6 6.2 9.3 5 6.1 9.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein SUIM_assoc PF16619.5 EFA81948.1 - 7.3 6.7 17.3 10 6.3 17.3 1.6 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Androgen_recep PF02166.16 EFA81948.1 - 9.3 5.0 9.1 10 4.8 9.1 1.1 1 0 0 1 1 1 0 Androgen receptor Activator_LAG-3 PF11498.8 EFA81949.1 - 7.3e-06 25.2 24.0 7.3e-06 25.2 24.0 6.2 4 1 1 5 5 5 1 Transcriptional activator LAG-3 Myb_DNA-binding PF00249.31 EFA81950.1 - 2.1e-06 27.8 0.2 7e-06 26.1 0.2 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Transformer PF06495.11 EFA81950.1 - 0.018 15.1 39.9 0.03 14.4 31.1 2.1 2 0 0 2 2 2 0 Fruit fly transformer protein Myb_DNA-bind_6 PF13921.6 EFA81950.1 - 0.02 15.1 0.3 0.058 13.7 0.3 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain CobT PF06213.12 EFA81950.1 - 0.22 10.9 19.6 0.24 10.7 4.9 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 EFA81950.1 - 4.6 6.9 18.2 2.4 7.8 2.5 2.5 2 0 0 2 2 2 0 FAM176 family Cdh1_DBD_1 PF18196.1 EFA81950.1 - 4.8 7.5 15.6 0.077 13.3 3.0 2.6 2 1 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 C2 PF00168.30 EFA81951.1 - 9.2e-17 61.2 0.2 2e-16 60.1 0.2 1.6 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 EFA81951.1 - 0.025 14.8 1.0 0.12 12.6 0.0 2.7 2 0 0 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain SPT16 PF08644.11 EFA81951.1 - 0.86 9.8 6.3 1.4 9.1 1.7 3.5 4 0 0 4 4 4 0 FACT complex subunit (SPT16/CDC68) PALP PF00291.25 EFA81952.1 - 1.3e-62 211.9 0.0 1.8e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Med25_VWA PF11265.8 EFA81952.1 - 3.6e-15 56.4 0.0 3.6e-15 56.4 0.0 3.0 3 0 0 3 3 3 1 Mediator complex subunit 25 von Willebrand factor type A ACP_syn_III_C PF08541.10 EFA81952.1 - 0.35 11.1 1.7 1.2 9.4 0.1 2.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal zf-ANAPC11 PF12861.7 EFA81953.1 - 1.8e-36 124.1 16.5 2.4e-36 123.7 16.5 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFA81953.1 - 6.5e-23 80.8 16.6 1.2e-22 79.9 16.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFA81953.1 - 1e-05 25.8 22.0 3.4e-05 24.1 19.7 2.4 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA81953.1 - 0.0004 20.2 9.1 0.0004 20.2 9.1 2.4 1 1 1 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA81953.1 - 0.013 15.5 9.2 0.037 14.1 9.3 1.7 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA81953.1 - 0.013 15.3 19.4 0.027 14.4 17.6 2.5 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EFA81953.1 - 0.021 14.7 5.8 0.039 13.8 5.8 1.6 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF5318 PF17249.2 EFA81953.1 - 0.039 13.7 1.4 0.49 10.2 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5318) Zn_ribbon_17 PF17120.5 EFA81953.1 - 0.62 9.7 18.8 5.2 6.8 17.6 2.4 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EFA81953.1 - 0.88 9.6 17.7 2.5 8.2 16.2 2.4 1 1 1 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.8 EFA81953.1 - 1.2 9.4 14.5 7.3 6.9 14.5 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_11 PF17123.5 EFA81953.1 - 7.4 6.4 14.9 52 3.7 14.9 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING-like PF08746.11 EFA81953.1 - 9.8 6.6 18.5 3.5 8.0 14.3 2.4 1 1 1 2 2 2 0 RING-like domain MIF4G PF02854.19 EFA81954.1 - 3.9e-25 88.7 4.9 1.1e-24 87.2 4.9 1.8 1 0 0 1 1 1 1 MIF4G domain VWA_3 PF13768.6 EFA81954.1 - 5e-21 75.3 0.0 1.3e-20 73.9 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain MA3 PF02847.17 EFA81954.1 - 2.8e-14 53.1 0.2 2.3e-13 50.1 0.2 2.4 1 1 0 1 1 1 1 MA3 domain VWA_2 PF13519.6 EFA81954.1 - 5e-13 49.6 0.0 3.3e-12 47.0 0.0 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFA81954.1 - 3.7e-10 40.3 0.0 1.6e-09 38.3 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VIT PF08487.10 EFA81954.1 - 5.7e-09 36.2 0.1 4.3e-08 33.3 0.1 2.3 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain PAM2 PF07145.15 EFA81954.1 - 0.33 10.7 6.8 0.38 10.5 2.5 2.8 2 0 0 2 2 2 0 Ataxin-2 C-terminal region NIF PF03031.18 EFA81955.1 - 2.8e-52 176.6 1.6 4e-52 176.1 1.6 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF4506 PF14958.6 EFA81956.1 - 2.7e-10 39.9 5.3 6.5e-10 38.7 5.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4506) DUF3340 PF11818.8 EFA81956.1 - 0.22 11.7 5.5 0.54 10.4 5.3 1.9 1 1 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) Nop16 PF09420.10 EFA81957.1 - 4.1e-14 53.1 14.0 2.4e-10 40.8 1.2 3.3 2 1 1 3 3 3 2 Ribosome biogenesis protein Nop16 TLV_coat PF00429.19 EFA81957.1 - 0.011 14.4 4.1 0.014 14.1 4.1 1.3 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) BCS1_N PF08740.11 EFA81958.1 - 2.4e-47 161.3 1.5 2.4e-47 161.3 1.5 2.0 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EFA81958.1 - 1.1e-15 58.2 0.0 3.7e-14 53.3 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA81958.1 - 0.00018 22.0 0.0 0.00056 20.3 0.0 1.8 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EFA81958.1 - 0.00048 19.4 0.0 0.00091 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 EFA81958.1 - 0.0058 16.5 0.3 0.014 15.2 0.3 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFA81958.1 - 0.0064 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 EFA81958.1 - 0.0067 16.8 0.0 0.017 15.5 0.0 1.8 1 1 0 1 1 1 1 RNA helicase PPV_E1_C PF00519.17 EFA81958.1 - 0.0068 15.3 0.0 0.077 11.8 0.0 2.0 2 0 0 2 2 2 1 Papillomavirus helicase ABC_tran PF00005.27 EFA81958.1 - 0.0094 16.5 0.2 0.026 15.1 0.2 1.7 1 1 0 1 1 1 1 ABC transporter AAA_25 PF13481.6 EFA81958.1 - 0.014 15.0 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFA81958.1 - 0.028 15.0 0.0 0.054 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Pex14_N PF04695.13 EFA81958.1 - 0.038 14.6 0.8 0.071 13.8 0.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_7 PF12775.7 EFA81958.1 - 0.038 13.5 0.0 0.083 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EFA81958.1 - 0.048 13.8 0.4 0.14 12.3 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFA81958.1 - 0.05 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFA81958.1 - 0.058 13.4 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFA81958.1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EFA81958.1 - 0.071 12.4 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 EFA81958.1 - 0.075 13.3 0.1 0.3 11.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain THUMP PF02926.17 EFA81959.1 - 1e-09 38.7 4.5 2.9e-09 37.2 4.5 1.8 1 0 0 1 1 1 1 THUMP domain FNIP PF05725.12 EFA81959.1 - 1.9e-07 31.2 19.3 0.04 14.1 0.0 7.5 6 2 2 8 8 8 3 FNIP Repeat F-box PF00646.33 EFA81959.1 - 0.0047 16.8 0.1 0.017 15.0 0.1 2.0 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EFA81959.1 - 0.089 12.4 0.3 0.18 11.4 0.3 1.4 1 0 0 1 1 1 0 F-box LRR_8 PF13855.6 EFA81959.1 - 0.1 12.4 4.2 2.7 7.8 0.0 4.3 3 1 2 5 5 5 0 Leucine rich repeat DUF5504 PF17608.2 EFA81960.1 - 0.042 14.0 2.4 0.12 12.4 0.9 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5504) DUF1240 PF06836.12 EFA81960.1 - 0.73 10.4 4.4 1.5 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) PEN-2 PF10251.9 EFA81961.1 - 5.3 7.5 7.7 3.8 8.0 0.7 2.5 2 0 0 2 2 2 0 Presenilin enhancer-2 subunit of gamma secretase TIG PF01833.24 EFA81962.1 - 8.1e-30 102.7 68.4 3.5e-08 33.4 5.6 11.4 11 0 0 11 11 11 7 IPT/TIG domain DNase_II PF03265.15 EFA81962.1 - 3e-24 85.9 6.6 4e-23 82.2 6.6 2.8 1 1 0 1 1 1 1 Deoxyribonuclease II SdrD_B PF17210.3 EFA81962.1 - 1.4e-13 51.0 0.8 3.4e-07 30.5 0.0 4.1 3 0 0 3 3 3 3 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA81962.1 - 0.0036 17.6 1.2 0.017 15.4 0.1 2.9 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain DUF3823 PF12866.7 EFA81962.1 - 0.059 13.7 0.1 0.3 11.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3823) N-terminal domain RRM_1 PF00076.22 EFA81963.1 - 0.00047 19.9 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAP_alpha PF03896.16 EFA81963.1 - 0.24 10.6 4.6 0.36 10.0 4.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit LMBR1 PF04791.16 EFA81965.1 - 3.7e-58 197.7 36.9 2.5e-49 168.6 11.3 3.5 2 1 2 4 4 4 3 LMBR1-like membrane protein Orf78 PF06024.12 EFA81965.1 - 0.037 14.3 0.7 0.037 14.3 0.7 3.4 3 0 0 3 3 3 0 Orf78 (ac78) GvpG PF05120.12 EFA81965.1 - 0.15 12.1 0.4 0.31 11.1 0.4 1.5 1 0 0 1 1 1 0 Gas vesicle protein G Methyltransf_12 PF08242.12 EFA81965.1 - 0.86 10.4 3.1 1.1 10.1 0.2 2.3 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.19 EFA81966.1 - 1e-46 159.3 0.0 1.4e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EFA81966.1 - 0.0025 17.6 0.0 0.12 12.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA81966.1 - 0.0068 17.1 0.0 0.031 15.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain GCD14 PF08704.10 EFA81966.1 - 0.035 13.8 0.1 0.95 9.1 0.0 2.5 1 1 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EFA81966.1 - 0.057 13.2 0.0 0.34 10.6 0.0 1.9 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EFA81966.1 - 0.068 12.5 0.0 0.17 11.2 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family SAP30_Sin3_bdg PF13867.6 EFA81966.1 - 0.086 13.2 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 TraY PF05509.11 EFA81966.1 - 1.5 8.9 4.5 3.9 7.6 4.0 1.9 2 0 0 2 2 2 0 TraY domain Pkinase_Tyr PF07714.17 EFA81967.1 - 8.9e-67 225.1 0.0 1.1e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA81967.1 - 9.1e-57 192.4 0.0 1.2e-56 192.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFA81967.1 - 0.00082 19.4 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFA81967.1 - 0.021 13.8 0.1 0.076 11.9 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain Sporozoite_P67 PF05642.11 EFA81967.1 - 0.089 10.9 7.5 0.12 10.4 7.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NICE-3 PF07406.11 EFA81967.1 - 0.15 12.0 0.3 0.59 10.1 0.1 1.8 2 0 0 2 2 2 0 NICE-3 protein PrgI PF12666.7 EFA81967.1 - 0.17 12.6 0.1 0.44 11.3 0.1 1.6 1 0 0 1 1 1 0 PrgI family protein PGBA_N PF15436.6 EFA81967.1 - 0.19 11.4 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA N-terminal Kinase-like PF14531.6 EFA81967.1 - 0.2 10.9 0.0 0.42 9.9 0.0 1.4 2 0 0 2 2 2 0 Kinase-like Pkinase_Tyr PF07714.17 EFA81968.1 - 1.4e-62 211.3 0.0 1.7e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA81968.1 - 6.6e-58 196.1 0.0 8.8e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFA81968.1 - 1.2e-05 25.4 0.2 4.4e-05 23.5 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFA81968.1 - 0.016 14.1 0.1 0.066 12.2 0.1 1.8 2 0 0 2 2 2 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EFA81968.1 - 0.042 12.6 0.0 0.058 12.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 EFA81968.1 - 0.068 12.2 1.4 0.1 11.6 0.1 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 Bact_lectin PF18483.1 EFA81969.1 - 1.5e-22 80.6 0.1 1.5e-22 80.6 0.1 3.0 2 1 0 2 2 2 1 Bacterial lectin Lectin_leg-like PF03388.13 EFA81969.1 - 1.6e-06 27.7 2.7 1.9e-06 27.4 0.1 2.4 2 1 0 2 2 2 1 Legume-like lectin family Ank_2 PF12796.7 EFA81970.1 - 4.2e-26 91.4 14.0 1.4e-05 25.6 0.1 6.7 1 1 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81970.1 - 3.4e-24 84.9 14.1 8.2e-05 23.1 0.3 9.0 7 2 2 9 9 9 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81970.1 - 8.9e-23 80.1 5.0 0.0021 18.4 0.1 10.6 5 4 6 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81970.1 - 2.6e-12 45.8 13.5 4 8.3 0.1 12.6 12 3 3 15 15 15 2 Ankyrin repeat DUF5049 PF16468.5 EFA81970.1 - 3.2e-06 26.9 0.1 39 4.3 0.0 7.0 5 1 1 6 6 6 0 Domain of unknown function (DUF5049) IL8 PF00048.20 EFA81970.1 - 0.063 13.4 0.1 96 3.2 0.0 4.6 5 1 0 5 5 5 0 Small cytokines (intecrine/chemokine), interleukin-8 like Phage_coat PF09063.10 EFA81970.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Phage PP7 coat protein Bact_lectin PF18483.1 EFA81971.1 - 5e-24 85.4 0.1 5e-24 85.4 0.1 3.0 3 0 0 3 3 3 1 Bacterial lectin Secretin_N_2 PF07655.13 EFA81971.1 - 0.87 10.2 18.0 3 8.4 18.0 1.9 1 0 0 1 1 1 0 Secretin N-terminal domain DAG_kinase_N PF14513.6 EFA81971.1 - 2.8 8.1 10.9 0.96 9.6 0.5 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Transglut_core PF01841.19 EFA81972.1 - 3.3e-14 53.3 0.1 1e-13 51.7 0.0 1.9 2 0 0 2 2 2 1 Transglutaminase-like superfamily UCH PF00443.29 EFA81974.1 - 7.3e-46 156.7 1.0 9e-46 156.4 1.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA81974.1 - 3e-18 66.5 0.8 4.1e-18 66.0 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFA81974.1 - 6e-12 45.2 0.4 2.3e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EFA81974.1 - 0.027 14.3 0.1 0.074 12.9 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Peptidase_C98 PF15499.6 EFA81974.1 - 0.075 12.5 0.7 0.58 9.6 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Asp PF00026.23 EFA81975.1 - 2.2e-114 382.1 2.6 2.6e-114 381.9 2.6 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFA81975.1 - 1.5e-13 51.4 2.8 1.1e-11 45.3 2.8 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFA81975.1 - 0.0072 16.9 0.3 0.053 14.2 0.0 2.6 3 1 0 3 3 3 1 Aspartyl protease TAXi_C PF14541.6 EFA81975.1 - 0.0086 15.9 0.0 0.034 13.9 0.0 1.9 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EFA81975.1 - 0.027 15.0 0.0 0.097 13.2 0.0 1.9 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease LRR_4 PF12799.7 EFA81979.1 - 0.15 12.6 33.5 0.74 10.3 2.4 7.3 7 2 3 10 10 10 0 Leucine Rich repeats (2 copies) zf-MYND PF01753.18 EFA81980.1 - 6.4e-08 32.6 14.1 1.5e-07 31.4 14.1 1.7 1 0 0 1 1 1 1 MYND finger DUF4642 PF15484.6 EFA81980.1 - 0.04 14.2 17.4 0.044 14.0 5.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4642) BSP_II PF05432.11 EFA81980.1 - 2.9 7.5 28.3 0.08 12.6 19.4 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PTPRCAP PF15713.5 EFA81980.1 - 3 8.1 20.0 0.18 12.1 12.0 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Tankyrase_bdg_C PF15327.6 EFA81980.1 - 8.8 6.8 16.0 0.76 10.2 7.3 2.6 2 0 0 2 2 2 0 Tankyrase binding protein C terminal domain BK_channel_a PF03493.18 EFA81981.1 - 1.4e-22 79.7 0.2 2.1e-21 75.9 0.1 2.8 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 EFA81981.1 - 4.1e-14 52.3 4.8 1.2e-13 50.8 4.8 1.8 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 EFA81981.1 - 1.2e-08 34.5 16.1 1.2e-08 34.5 16.1 3.3 3 1 0 3 3 3 1 Ion transport protein Castor_Poll_mid PF06241.12 EFA81981.1 - 2.1e-06 27.7 0.9 0.009 16.0 0.3 2.9 2 1 0 2 2 2 2 Castor and Pollux, part of voltage-gated ion channel TrkA_N PF02254.18 EFA81981.1 - 5.4e-06 26.6 0.0 0.00038 20.7 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain Menin PF05053.13 EFA81981.1 - 1.1 7.5 8.0 1.8 6.8 8.0 1.2 1 0 0 1 1 1 0 Menin FtsX PF02687.21 EFA81982.1 - 0.019 15.4 1.5 0.93 10.0 0.1 2.2 2 0 0 2 2 2 0 FtsX-like permease family ABC2_membrane PF01061.24 EFA81982.1 - 0.088 12.2 2.2 0.16 11.3 0.1 2.0 2 0 0 2 2 2 0 ABC-2 type transporter DUF3139 PF11337.8 EFA81982.1 - 0.15 12.8 3.0 0.29 11.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Kei1 PF08552.11 EFA81982.1 - 0.18 11.7 1.8 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2500 PF10694.9 EFA81982.1 - 0.35 11.4 0.1 0.35 11.4 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) ABC2_membrane_3 PF12698.7 EFA81982.1 - 0.49 9.4 3.8 1.5 7.8 0.6 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein Ctr PF04145.15 EFA81982.1 - 0.56 10.8 0.0 0.56 10.8 0.0 2.8 3 0 0 3 3 3 0 Ctr copper transporter family OppC_N PF12911.7 EFA81982.1 - 0.99 9.4 0.0 0.99 9.4 0.0 2.9 3 1 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C FAM176 PF14851.6 EFA81982.1 - 1 9.0 0.0 1 9.0 0.0 3.0 2 1 1 3 3 3 0 FAM176 family DUF4834 PF16118.5 EFA81982.1 - 3.2 8.8 7.7 4.4 8.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Roughex PF06020.11 EFA81983.1 - 4.3 6.3 8.3 5.6 6.0 1.9 2.4 2 0 0 2 2 2 0 Drosophila roughex protein Dicty_REP PF05086.12 EFA81984.1 - 0.073 11.1 6.3 0.092 10.7 6.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AMP-binding PF00501.28 EFA81985.1 - 3.6e-46 157.6 0.0 5e-34 117.6 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme ZZ PF00569.17 EFA81985.1 - 0.59 10.0 8.6 1.2 9.0 8.6 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Ank_2 PF12796.7 EFA81986.1 - 3.7e-43 146.0 9.5 7.3e-07 29.7 0.0 9.4 7 1 2 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA81986.1 - 7.6e-36 122.0 16.8 0.0066 17.0 0.0 15.1 11 3 4 15 15 15 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA81986.1 - 4.5e-29 100.1 24.4 0.0082 16.4 0.0 17.3 9 4 10 19 19 19 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA81986.1 - 8.6e-23 78.0 22.1 0.29 11.8 0.0 19.4 24 0 0 24 24 24 5 Ankyrin repeat DUF3447 PF11929.8 EFA81986.1 - 0.0086 16.0 30.9 0.93 9.5 0.5 9.3 7 2 4 11 11 11 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA81986.1 - 0.014 15.9 6.0 6.8 7.3 0.0 7.0 9 1 0 9 9 9 0 Ankyrin repeat DUF4028 PF13220.6 EFA81986.1 - 0.33 10.7 2.4 2.5 8.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4028) DSPc PF00782.20 EFA81987.1 - 2.7e-20 72.5 0.4 1.2e-14 54.3 0.0 5.5 6 0 0 6 6 6 2 Dual specificity phosphatase, catalytic domain Androgen_recep PF02166.16 EFA81987.1 - 0.18 10.6 3.5 2.9 6.6 0.1 2.1 2 0 0 2 2 2 0 Androgen receptor SUIM_assoc PF16619.5 EFA81987.1 - 0.88 9.7 17.0 0.35 11.0 1.3 3.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TRAF_BIRC3_bd PF16673.5 EFA81988.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain ADIP PF11559.8 EFA81988.1 - 0.019 15.1 0.1 0.023 14.8 0.1 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Scramblase PF03803.15 EFA81988.1 - 0.27 10.5 2.2 0.34 10.2 2.0 1.3 1 1 0 1 1 1 0 Scramblase Mago_nashi PF02792.14 EFA81989.1 - 4.8e-25 88.3 3.0 3e-23 82.5 3.0 2.1 1 1 0 1 1 1 1 Mago nashi protein DUF2500 PF10694.9 EFA81990.1 - 0.52 10.8 0.0 0.52 10.8 0.0 4.1 4 2 0 4 4 4 0 Protein of unknown function (DUF2500) TRAM_LAG1_CLN8 PF03798.16 EFA81991.1 - 1.7e-31 109.5 19.4 2.7e-31 108.8 19.4 1.3 1 0 0 1 1 1 1 TLC domain RhoGEF PF00621.20 EFA81992.1 - 1.1e-45 156.1 4.5 1.1e-45 156.1 4.5 3.9 3 2 0 3 3 3 1 RhoGEF domain PX PF00787.24 EFA81992.1 - 2e-18 66.4 1.3 2e-18 66.4 1.3 3.8 4 0 0 4 4 4 1 PX domain ATG_C PF09333.11 EFA81993.1 - 3.4e-36 123.5 1.4 4.3e-36 123.1 0.5 1.6 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 EFA81994.1 - 3.3e-12 46.5 0.0 3.3e-12 46.5 0.0 4.0 4 0 0 4 4 4 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 EFA81994.1 - 1.7e-10 40.8 0.1 1.7e-10 40.8 0.1 5.0 6 0 0 6 6 6 1 Autophagy-related protein 2 CAD motif Pex26 PF07163.12 EFA81994.1 - 8.2 5.6 10.7 3.4 6.9 1.5 3.1 3 0 0 3 3 3 0 Pex26 protein Macoilin PF09726.9 EFA81995.1 - 0.043 12.4 19.0 0.052 12.1 19.0 1.1 1 0 0 1 1 1 0 Macoilin family Nuc_deoxyri_tr3 PF11071.8 EFA81995.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase YtoQ Presenilin PF01080.17 EFA81995.1 - 4 6.1 9.4 5 5.8 9.4 1.2 1 0 0 1 1 1 0 Presenilin UNC-50 PF05216.13 EFA81996.1 - 2.6e-58 197.2 18.8 3.2e-58 196.9 18.8 1.0 1 0 0 1 1 1 1 UNC-50 family DUF1474 PF07342.11 EFA81996.1 - 0.021 15.4 0.1 0.034 14.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) Orf78 PF06024.12 EFA81996.1 - 0.089 13.1 2.1 1.5 9.1 0.3 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Peptidase_U4 PF03419.13 EFA81996.1 - 0.29 10.4 7.5 0.42 9.8 7.5 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA FtsX PF02687.21 EFA81996.1 - 2.3 8.8 10.9 0.097 13.1 2.6 2.2 1 1 1 2 2 2 0 FtsX-like permease family DENN PF02141.21 EFA81997.1 - 8.6e-24 84.5 16.3 3.2e-23 82.7 0.8 4.5 4 0 0 4 4 4 2 DENN (AEX-3) domain uDENN PF03456.18 EFA81997.1 - 0.00024 21.8 0.0 0.0012 19.5 0.0 2.4 1 0 0 1 1 1 1 uDENN domain GlcNAc PF11397.8 EFA81998.1 - 2.9e-89 300.0 0.5 5.3e-76 256.4 0.2 2.4 1 1 1 2 2 2 2 Glycosyltransferase (GlcNAc) GATA PF00320.27 EFA81998.1 - 1.9e-14 52.9 5.3 5.3e-14 51.5 5.3 1.8 1 0 0 1 1 1 1 GATA zinc finger HNOB PF07700.15 EFA81998.1 - 0.12 12.4 0.4 2.8 7.9 0.1 2.5 2 0 0 2 2 2 0 Haem-NO-binding TolA_bind_tri PF16331.5 EFA81998.1 - 0.14 12.2 6.7 0.43 10.7 0.0 3.2 2 0 0 2 2 2 0 TolA binding protein trimerisation RNA_ligase PF09414.10 EFA81999.1 - 3.6e-22 79.4 0.1 1.2e-21 77.7 0.1 1.7 2 0 0 2 2 2 1 RNA ligase tRNA-synt_1g PF09334.11 EFA82000.1 - 3.1e-100 335.7 0.1 1.3e-99 333.6 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFA82000.1 - 1.6e-19 69.6 1.4 5.5e-11 41.4 0.4 3.4 3 1 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EFA82000.1 - 1.9e-06 27.5 0.0 0.022 14.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EFA82000.1 - 0.00015 21.7 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 EFA82000.1 - 0.025 13.5 0.1 0.23 10.4 0.0 2.4 2 1 0 2 2 2 0 tRNA synthetases class I (K) PP1 PF07430.11 EFA82000.1 - 0.1 12.6 0.4 0.59 10.2 0.1 2.1 2 0 0 2 2 2 0 Phloem filament protein PP1 cystatin-like domain EGF_2 PF07974.13 EFA82001.1 - 8.3e-05 22.9 8.9 0.00018 21.8 8.9 1.6 1 0 0 1 1 1 1 EGF-like domain DUF4845 PF16137.5 EFA82001.1 - 0.05 14.5 0.0 12 6.8 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4845) EGF_Tenascin PF18720.1 EFA82001.1 - 0.65 10.1 4.2 2 8.6 4.2 1.8 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 EFA82001.1 - 6.9 7.5 8.1 17 6.2 8.1 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.13 EFA82002.1 - 6.9e-05 23.1 12.5 0.00014 22.1 12.5 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA82002.1 - 0.18 11.9 5.9 0.44 10.7 5.9 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF_alliinase PF04863.13 EFA82002.1 - 0.62 10.5 2.8 1.2 9.5 2.8 1.4 1 0 0 1 1 1 0 Alliinase EGF-like domain Laminin_EGF PF00053.24 EFA82002.1 - 1.3 9.2 9.7 3 8.0 9.7 1.6 1 0 0 1 1 1 0 Laminin EGF domain ABC2_membrane PF01061.24 EFA82003.1 - 1.2e-78 263.3 56.5 2.9e-44 151.0 21.6 2.5 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EFA82003.1 - 6.9e-37 127.0 0.0 4.4e-18 66.1 0.0 2.8 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EFA82003.1 - 4.5e-29 100.2 2.4 2.8e-21 75.2 0.1 3.2 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EFA82003.1 - 8.4e-09 35.9 0.0 2.1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EFA82003.1 - 7.7e-07 29.2 0.2 0.00011 22.1 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase ABC2_membrane_3 PF12698.7 EFA82003.1 - 4.9e-06 25.9 22.7 4.9e-06 25.9 22.7 3.5 2 2 1 3 3 3 2 ABC-2 family transporter protein AAA_29 PF13555.6 EFA82003.1 - 1.8e-05 24.4 0.8 0.0069 16.1 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFA82003.1 - 3.3e-05 23.9 0.0 0.095 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFA82003.1 - 0.00038 20.7 0.0 0.4 10.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA82003.1 - 0.00044 20.7 0.0 0.42 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EFA82003.1 - 0.0061 16.2 0.1 0.049 13.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA82003.1 - 0.0063 16.3 0.6 2.2 8.0 0.2 3.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EFA82003.1 - 0.013 16.1 0.0 0.77 10.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFA82003.1 - 0.026 14.4 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EFA82003.1 - 0.04 14.0 0.0 4.7 7.3 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA PF00004.29 EFA82003.1 - 0.061 13.7 0.1 7.4 7.0 0.1 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EFA82003.1 - 0.065 12.5 0.0 2.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 EFA82003.1 - 0.077 13.2 0.0 0.63 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFA82003.1 - 0.084 12.5 0.2 0.49 10.0 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EFA82003.1 - 0.52 10.5 2.4 0.61 10.3 0.3 2.3 3 0 0 3 3 1 0 AAA domain PhyH PF05721.13 EFA82004.1 - 2e-31 109.9 0.0 2.4e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EFA82004.1 - 0.005 17.2 0.0 0.0093 16.4 0.0 1.5 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 EFA82004.1 - 0.029 15.3 0.0 0.12 13.2 0.0 2.0 2 1 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily HD PF01966.22 EFA82005.1 - 6.5e-06 26.4 0.0 8.7e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 HD domain MIOX PF05153.15 EFA82005.1 - 2.7e-05 23.9 0.1 3.8e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Myo-inositol oxygenase HD_4 PF13328.6 EFA82005.1 - 4e-05 23.4 1.5 0.00023 20.9 1.5 2.1 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 EFA82005.1 - 0.00029 20.4 0.1 0.0005 19.6 0.1 1.5 1 0 0 1 1 1 1 HDOD domain GYF PF02213.16 EFA82005.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 GYF domain Macoilin PF09726.9 EFA82006.1 - 0.00044 19.0 31.4 0.00044 19.0 31.4 3.3 1 1 2 3 3 3 2 Macoilin family TFIID_30kDa PF03540.13 EFA82007.1 - 1.5e-16 60.0 0.0 2.3e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit SOG2 PF10428.9 EFA82007.1 - 0.1 11.8 18.7 0.11 11.7 18.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIF_alpha PF05793.12 EFA82007.1 - 0.49 8.9 20.9 0.5 8.9 20.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 EFA82007.1 - 0.66 8.5 16.6 0.73 8.3 16.6 1.2 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 EFA82007.1 - 0.87 7.9 15.7 1.4 7.2 15.7 1.4 1 1 0 1 1 1 0 Menin DUF2981 PF11200.8 EFA82007.1 - 1 9.0 5.0 1.2 8.8 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SAPS PF04499.15 EFA82007.1 - 1.1 7.9 7.5 1.3 7.7 7.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PT PF04886.12 EFA82008.1 - 0.00073 19.0 18.0 0.013 15.0 9.5 3.2 2 1 0 2 2 2 2 PT repeat DUF5638 PF18688.1 EFA82009.1 - 0.32 11.3 0.1 0.32 11.3 0.1 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5638) Ank_2 PF12796.7 EFA82011.1 - 4.2e-28 97.8 1.0 1.1e-14 54.8 0.2 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82011.1 - 4.6e-21 74.9 1.8 1.2e-05 25.8 0.0 5.4 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82011.1 - 1.6e-20 71.0 0.4 0.0031 17.9 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EFA82011.1 - 5.2e-14 52.0 5.7 0.0098 16.3 0.0 6.1 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EFA82011.1 - 0.0024 18.1 30.9 0.015 15.6 0.0 6.6 5 2 3 8 8 8 5 Ankyrin repeats (many copies) AT_hook PF02178.19 EFA82011.1 - 7.9 6.7 12.4 0.7 10.0 6.8 2.4 2 0 0 2 2 2 0 AT hook motif adh_short PF00106.25 EFA82012.1 - 7.2e-47 159.4 0.3 1e-46 158.9 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA82012.1 - 3e-34 118.6 0.2 3.8e-34 118.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA82012.1 - 8.9e-15 55.1 0.0 1.2e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA82012.1 - 0.00042 19.9 0.8 0.0073 15.8 0.9 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA82012.1 - 0.0009 19.2 0.3 0.0018 18.2 0.1 1.6 2 0 0 2 2 2 1 NAD(P)H-binding ADH_zinc_N PF00107.26 EFA82012.1 - 0.0011 19.0 0.1 0.003 17.6 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase RmlD_sub_bind PF04321.17 EFA82012.1 - 0.062 12.4 0.1 0.095 11.8 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short PF00106.25 EFA82013.1 - 5.7e-47 159.7 0.1 7.6e-47 159.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA82013.1 - 8.5e-34 117.1 0.0 1.1e-33 116.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA82013.1 - 2.2e-09 37.5 0.0 3.3e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EFA82013.1 - 0.0015 18.5 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 EFA82013.1 - 0.021 14.3 0.2 0.062 12.7 0.2 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family UPF0556 PF10572.9 EFA82014.1 - 1.1e-08 34.7 0.0 1.4e-08 34.3 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family UPF0556 Vps36_ESCRT-II PF11605.8 EFA82014.1 - 0.048 13.9 0.2 0.15 12.3 0.1 1.7 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 B-block_TFIIIC PF04182.12 EFA82015.1 - 3.8e-14 52.6 2.9 1e-11 44.8 0.1 4.5 4 0 0 4 4 4 2 B-block binding subunit of TFIIIC BUD22 PF09073.10 EFA82015.1 - 9.3e-05 21.9 26.9 9.3e-05 21.9 26.9 4.9 4 1 0 4 4 4 1 BUD22 Methyltransf_16 PF10294.9 EFA82016.1 - 8.4e-25 87.5 1.9 3.6e-15 56.1 0.0 2.1 1 1 1 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 EFA82016.1 - 1.1e-06 28.6 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA82016.1 - 0.00087 20.0 0.1 0.01 16.5 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFA82016.1 - 0.029 14.0 0.2 3.7 7.1 0.4 2.1 1 1 1 2 2 2 0 Nodulation protein S (NodS) Methyltransf_25 PF13649.6 EFA82016.1 - 0.031 15.0 0.0 1.2 9.9 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFA82016.1 - 0.052 14.2 0.0 1.2 9.8 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EFA82016.1 - 0.056 13.2 0.3 0.091 12.6 0.3 1.6 1 1 0 1 1 1 0 Methyltransferase domain Roughex PF06020.11 EFA82017.1 - 0.0044 16.2 1.7 0.0049 16.0 1.7 1.1 1 0 0 1 1 1 1 Drosophila roughex protein Homeodomain PF00046.29 EFA82017.1 - 0.012 15.4 0.1 0.023 14.5 0.1 1.4 1 0 0 1 1 1 0 Homeodomain F-protein PF00469.20 EFA82017.1 - 0.014 15.0 1.3 0.019 14.6 1.3 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef NPH-II PF12011.8 EFA82017.1 - 0.069 13.0 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 RNA helicase NPH-II FAM176 PF14851.6 EFA82017.1 - 0.51 10.0 3.8 0.79 9.4 3.8 1.2 1 0 0 1 1 1 0 FAM176 family DGF-1_C PF11040.8 EFA82017.1 - 1 9.4 6.2 1.3 9.0 4.4 2.1 1 1 1 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus NINJA_B PF16136.5 EFA82017.1 - 1.8 9.0 5.8 3 8.3 5.8 1.3 1 0 0 1 1 1 0 Putative nuclear localisation signal Presenilin PF01080.17 EFA82017.1 - 5.4 5.7 4.7 6.8 5.3 4.7 1.1 1 0 0 1 1 1 0 Presenilin zf-4CXXC_R1 PF10497.9 EFA82018.1 - 1.2e-10 41.5 14.7 1.2e-10 41.5 14.7 2.4 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 PWWP PF00855.17 EFA82018.1 - 1.6e-09 38.0 0.8 5.1e-09 36.4 0.0 2.3 2 0 0 2 2 2 1 PWWP domain JmjC PF02373.22 EFA82018.1 - 3e-07 30.9 0.0 3e-07 30.9 0.0 3.4 3 0 0 3 3 3 1 JmjC domain, hydroxylase DnaJ PF00226.31 EFA82019.1 - 7.3e-16 58.1 1.2 1.3e-15 57.2 0.0 2.1 2 0 0 2 2 1 1 DnaJ domain Zip PF02535.22 EFA82019.1 - 0.00079 18.7 1.6 0.12 11.6 0.1 2.3 2 0 0 2 2 2 1 ZIP Zinc transporter Connexin PF00029.19 EFA82019.1 - 0.0014 18.5 2.3 0.49 10.1 0.2 2.3 2 0 0 2 2 2 2 Connexin Tim54 PF11711.8 EFA82019.1 - 0.0048 15.7 0.5 0.0048 15.7 0.5 2.3 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 EFA82019.1 - 0.0052 15.8 2.8 0.06 12.3 1.1 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) SpoIIIAH PF12685.7 EFA82019.1 - 0.0058 16.5 8.4 0.041 13.7 1.5 2.6 3 0 0 3 3 3 1 SpoIIIAH-like protein CLN3 PF02487.17 EFA82019.1 - 0.006 15.7 0.9 0.36 9.8 0.0 2.2 2 0 0 2 2 2 1 CLN3 protein DUF2052 PF09747.9 EFA82019.1 - 0.0065 16.6 14.9 0.1 12.8 6.3 2.5 3 0 0 3 3 2 2 Coiled-coil domain containing protein (DUF2052) Mlh1_C PF16413.5 EFA82019.1 - 0.015 14.6 2.5 0.39 10.1 0.4 2.5 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus EMC3_TMCO1 PF01956.16 EFA82019.1 - 0.026 14.3 2.5 0.058 13.1 2.5 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Nop14 PF04147.12 EFA82019.1 - 0.037 12.3 23.6 0.044 12.0 18.2 2.1 2 0 0 2 2 2 0 Nop14-like family Peroxin-13_N PF04088.13 EFA82019.1 - 0.044 14.1 0.4 0.044 14.1 0.4 2.9 3 1 0 3 3 2 0 Peroxin 13, N-terminal region PEX11 PF05648.14 EFA82019.1 - 0.059 12.8 0.3 0.059 12.8 0.3 2.2 2 1 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Pex14_N PF04695.13 EFA82019.1 - 0.067 13.9 3.8 1.5 9.5 0.3 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EIIBC-GUT_N PF03612.14 EFA82019.1 - 0.1 12.4 4.9 1.6 8.4 0.5 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus GNAT_acetyltr_2 PF13718.6 EFA82019.1 - 0.12 11.7 7.3 0.46 9.8 0.2 2.3 2 0 0 2 2 2 0 GNAT acetyltransferase 2 CSG2 PF16965.5 EFA82019.1 - 0.24 10.3 2.4 7.8 5.3 0.3 2.2 2 0 0 2 2 2 0 Ceramide synthase regulator V_ATPase_I PF01496.19 EFA82019.1 - 0.39 8.6 10.7 0.35 8.7 0.3 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF3292 PF11696.8 EFA82019.1 - 0.48 8.7 4.0 3 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) CNDH2_C PF16858.5 EFA82019.1 - 0.7 9.7 16.0 1.7 8.5 7.4 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RXT2_N PF08595.11 EFA82019.1 - 0.88 9.6 27.4 0.22 11.5 0.2 2.7 3 0 0 3 3 2 0 RXT2-like, N-terminal DUF4834 PF16118.5 EFA82019.1 - 1.1 10.3 15.3 0.3 12.1 1.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) G0-G1_switch_2 PF15103.6 EFA82019.1 - 1.3 9.5 6.8 0.27 11.7 0.3 2.4 2 0 0 2 2 2 0 G0/G1 switch protein 2 PPL5 PF18168.1 EFA82019.1 - 1.3 8.3 8.0 5.4 6.2 2.7 2.3 2 0 0 2 2 2 0 Prim-pol family 5 Vfa1 PF08432.10 EFA82019.1 - 1.4 9.2 20.7 0.046 14.0 3.7 2.5 3 0 0 3 3 2 0 AAA-ATPase Vps4-associated protein 1 Sigma70_ner PF04546.13 EFA82019.1 - 1.5 8.7 19.4 9.1 6.1 0.2 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region GCD14 PF08704.10 EFA82019.1 - 2.3 7.8 6.0 4 7.0 0.4 2.3 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit RR_TM4-6 PF06459.12 EFA82019.1 - 3.3 7.4 15.6 0.15 11.9 1.5 2.4 3 0 0 3 3 2 0 Ryanodine Receptor TM 4-6 Bcl-2_BAD PF10514.9 EFA82019.1 - 3.4 8.1 7.4 0.11 12.9 0.7 1.8 2 0 0 2 2 1 0 Pro-apoptotic Bcl-2 protein, BAD CPSF100_C PF13299.6 EFA82019.1 - 3.8 7.7 14.8 1.5 9.0 0.2 2.6 3 0 0 3 3 2 0 Cleavage and polyadenylation factor 2 C-terminal Ferlin_C PF16165.5 EFA82019.1 - 3.9 7.4 6.9 1.2 9.1 0.2 2.4 2 0 0 2 2 2 0 Ferlin C-terminus CobT PF06213.12 EFA82019.1 - 4 6.7 28.3 2.5 7.4 16.9 2.5 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT FAM150 PF15129.6 EFA82019.1 - 4.4 7.5 9.8 4.7 7.4 0.6 2.6 2 0 0 2 2 2 0 FAM150 family MRNIP PF15749.5 EFA82019.1 - 5.5 7.8 21.7 0.24 12.1 0.8 3.0 3 0 0 3 3 3 0 MRN-interacting protein TRAP_alpha PF03896.16 EFA82019.1 - 5.7 6.0 16.5 8.1 5.6 12.3 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.10 EFA82019.1 - 7 5.9 27.1 2.1 7.6 0.4 2.3 3 0 0 3 3 2 0 BUD22 Afi1 PF07792.12 EFA82019.1 - 7.3 7.1 21.6 5.6 7.4 0.4 2.9 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 EFA82019.1 - 7.4 4.7 23.3 16 3.6 0.1 2.2 2 0 0 2 2 2 0 CDC45-like protein PI3K_1B_p101 PF10486.9 EFA82019.1 - 8.3 4.0 9.9 1.3 6.7 3.1 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Kelch_6 PF13964.6 EFA82020.1 - 2.2e-20 72.1 6.1 1.2e-10 41.2 0.1 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFA82020.1 - 0.0055 16.3 0.1 0.056 13.0 0.0 2.5 2 0 0 2 2 2 1 Kelch motif zf-B_box PF00643.24 EFA82020.1 - 0.04 14.1 16.3 0.11 12.7 16.3 1.7 1 0 0 1 1 1 0 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82020.1 - 0.046 14.1 0.2 0.14 12.6 0.2 1.8 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Kelch_2 PF07646.15 EFA82020.1 - 0.3 11.1 1.1 2.3 8.3 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Vps52 PF04129.12 EFA82021.1 - 3.6e-76 257.0 21.4 9.1e-76 255.6 21.4 1.5 1 1 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EFA82021.1 - 0.87 7.9 14.8 0.72 8.2 10.6 2.4 2 1 0 2 2 2 0 Exocyst complex component Sec3 Kelch_6 PF13964.6 EFA82022.1 - 1.7e-18 66.2 6.4 1.9e-11 43.8 0.2 5.2 4 1 1 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA82022.1 - 0.00081 19.5 10.9 0.0021 18.2 10.9 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA82022.1 - 0.0042 16.6 0.4 0.039 13.5 0.0 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EFA82022.1 - 0.011 15.7 2.7 0.57 10.2 0.2 4.0 4 0 0 4 4 4 0 Galactose oxidase, central domain Saccharop_dh_N PF04455.12 EFA82022.1 - 0.016 15.6 0.2 0.065 13.7 0.2 2.0 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Hfq PF17209.3 EFA82022.1 - 0.027 14.1 0.2 0.089 12.4 0.2 1.9 1 0 0 1 1 1 0 Hfq protein DUF1217 PF06748.12 EFA82022.1 - 0.046 13.8 2.9 0.063 13.3 1.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1217) Kelch_2 PF07646.15 EFA82022.1 - 0.11 12.5 1.9 0.38 10.8 0.2 2.8 3 0 0 3 3 3 0 Kelch motif zf-piccolo PF05715.13 EFA82022.1 - 0.22 11.7 2.4 0.53 10.5 2.4 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger CREPT PF16566.5 EFA82022.1 - 0.39 10.9 6.9 0.14 12.4 1.5 2.5 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3958 PF13125.6 EFA82022.1 - 1.9 8.7 9.2 0.3 11.3 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Hce2 PF14856.6 EFA82023.1 - 0.065 13.5 2.0 0.15 12.4 0.8 1.8 1 1 1 2 2 2 0 Pathogen effector; putative necrosis-inducing factor TRAM_LAG1_CLN8 PF03798.16 EFA82024.1 - 3.3e-19 69.4 16.1 5e-19 68.8 16.1 1.3 1 0 0 1 1 1 1 TLC domain Ribonuc_P_40 PF08584.11 EFA82025.1 - 2.7e-49 168.0 3.4 8.7e-37 126.9 0.0 2.7 2 1 1 3 3 3 2 Ribonuclease P 40kDa (Rpp40) subunit Mtc PF03820.17 EFA82025.1 - 0.6 9.1 2.7 0.86 8.6 2.7 1.2 1 0 0 1 1 1 0 Tricarboxylate carrier Hemocyanin_M PF00372.19 EFA82026.1 - 1.8e-38 132.3 0.0 2.9e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Hemocyanin, copper containing domain Hemocyanin_C PF03723.14 EFA82026.1 - 2.5e-21 76.1 0.0 4.1e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Hemocyanin, ig-like domain Tyrosinase PF00264.20 EFA82026.1 - 0.0017 18.7 0.1 0.0041 17.4 0.1 1.6 1 0 0 1 1 1 1 Common central domain of tyrosinase Kelch_6 PF13964.6 EFA82028.1 - 1.9e-17 62.9 4.6 2.8e-10 40.1 0.1 4.8 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA82028.1 - 0.0025 17.9 7.9 0.0057 16.8 7.9 1.6 1 0 0 1 1 1 1 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82028.1 - 0.015 15.6 0.1 0.064 13.7 0.1 2.1 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Kelch_1 PF01344.25 EFA82028.1 - 0.018 14.6 0.0 0.11 12.1 0.0 2.3 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA82028.1 - 0.039 14.0 3.8 4.4 7.4 0.0 4.8 5 0 0 5 5 5 0 Galactose oxidase, central domain CREPT PF16566.5 EFA82028.1 - 0.96 9.6 6.3 0.19 11.9 1.3 2.2 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3958 PF13125.6 EFA82028.1 - 3.6 7.8 9.2 0.31 11.2 4.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Kelch_6 PF13964.6 EFA82030.1 - 7.1e-19 67.4 9.2 3.1e-11 43.1 0.1 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA82030.1 - 0.00037 20.0 0.4 0.027 14.0 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EFA82030.1 - 0.0011 18.9 1.5 0.51 10.4 0.1 3.9 3 0 0 3 3 3 1 Galactose oxidase, central domain zf-B_box PF00643.24 EFA82030.1 - 0.024 14.8 13.9 0.048 13.8 13.9 1.5 1 0 0 1 1 1 0 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82030.1 - 0.03 14.7 0.6 0.084 13.3 0.2 2.0 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region Kelch_2 PF07646.15 EFA82030.1 - 0.031 14.3 0.4 0.5 10.4 0.1 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 EFA82030.1 - 0.048 14.0 0.1 14 6.1 0.0 3.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA82030.1 - 0.063 13.3 0.6 0.24 11.5 0.6 2.0 1 0 0 1 1 1 0 Kelch motif S6PP_C PF08472.10 EFA82030.1 - 0.092 12.6 0.1 0.26 11.2 0.1 1.8 1 0 0 1 1 1 0 Sucrose-6-phosphate phosphohydrolase C-terminal NHL PF01436.21 EFA82030.1 - 0.75 10.0 2.9 6.2 7.1 0.0 2.9 3 0 0 3 3 3 0 NHL repeat Peptidase_M1 PF01433.20 EFA82031.1 - 3.4e-76 255.6 0.8 6.9e-76 254.6 0.8 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFA82031.1 - 6.6e-75 252.6 0.5 1.1e-74 251.8 0.0 1.6 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFA82031.1 - 2e-56 191.1 0.0 3.4e-56 190.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M48 PF01435.18 EFA82031.1 - 0.16 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M48 FNIP PF05725.12 EFA82033.1 - 2.7e-23 81.9 30.9 0.0002 21.5 0.1 9.1 7 1 2 10 10 10 9 FNIP Repeat Kelch_6 PF13964.6 EFA82034.1 - 5.5e-16 58.2 4.8 4.1e-11 42.8 0.1 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA82034.1 - 0.0015 18.1 0.2 0.011 15.4 0.0 2.4 2 0 0 2 2 2 1 Kelch motif DUF1217 PF06748.12 EFA82034.1 - 0.0027 17.8 1.4 0.0057 16.7 1.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1217) Saccharop_dh_N PF04455.12 EFA82034.1 - 0.015 15.7 0.2 0.059 13.8 0.2 2.0 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Kelch_4 PF13418.6 EFA82034.1 - 0.026 14.5 0.8 0.51 10.4 0.1 3.3 4 0 0 4 4 4 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA82034.1 - 0.047 13.8 13.3 0.11 12.7 13.3 1.5 1 0 0 1 1 1 0 B-box zinc finger Kelch_2 PF07646.15 EFA82034.1 - 0.075 13.1 0.1 0.37 10.8 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 EFA82034.1 - 0.14 12.1 2.1 0.19 11.8 0.6 2.0 2 0 0 2 2 2 0 Kelch motif BRCT PF00533.26 EFA82035.1 - 8e-09 35.8 1.1 8e-09 35.8 1.1 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA82035.1 - 1.4e-05 25.4 3.1 1.9e-05 25.0 0.4 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFA82035.1 - 0.0002 21.2 0.4 0.0012 18.7 0.1 2.3 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 EFA82035.1 - 0.0061 16.8 0.1 0.0061 16.8 0.1 2.6 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain Kelch_6 PF13964.6 EFA82036.1 - 6.8e-16 57.9 3.6 3.6e-10 39.8 0.1 4.8 4 1 1 5 5 5 2 Kelch motif Kelch_4 PF13418.6 EFA82036.1 - 0.00091 19.2 1.4 1.7 8.7 0.2 4.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA82036.1 - 0.0058 16.2 0.3 0.031 13.8 0.1 2.4 3 0 0 3 3 3 1 Kelch motif UPF0449 PF15136.6 EFA82036.1 - 0.18 12.3 1.0 0.62 10.6 1.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Kelch_2 PF07646.15 EFA82036.1 - 0.45 10.6 1.9 2.5 8.2 1.9 2.4 1 1 0 1 1 1 0 Kelch motif Col_cuticle_N PF01484.17 EFA82036.1 - 0.59 10.3 8.5 0.19 11.8 0.6 3.2 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain F-box_5 PF18511.1 EFA82037.1 - 0.15 11.7 0.2 0.5 10.0 0.1 1.9 2 0 0 2 2 2 0 F-box SH3_1 PF00018.28 EFA82039.1 - 6e-14 51.4 0.1 6e-14 51.4 0.1 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EFA82039.1 - 2.4e-10 40.1 0.1 4.7e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA82039.1 - 2e-08 33.8 0.0 3.2e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain DUF4905 PF16248.5 EFA82040.1 - 0.092 12.7 0.3 1.9 8.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4905) Uma2 PF05685.12 EFA82041.1 - 1.1e-10 41.4 0.0 1.5e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease DDE_Tnp_1_7 PF13843.6 EFA82042.1 - 1.9e-102 343.2 2.9 2.4e-102 342.9 2.9 1.1 1 0 0 1 1 1 1 Transposase IS4 SAP PF02037.27 EFA82042.1 - 0.057 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 SAP domain Kelch_6 PF13964.6 EFA82045.1 - 0.001 19.3 1.1 0.097 13.0 0.0 3.0 2 2 1 3 3 3 2 Kelch motif DUF3430 PF11912.8 EFA82046.1 - 0.036 14.1 31.4 0.15 12.1 31.5 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3430) Kelch_6 PF13964.6 EFA82048.1 - 1.3e-15 57.1 2.5 6.4e-10 39.0 0.1 3.7 2 1 1 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA82048.1 - 0.0082 16.3 10.3 0.019 15.1 10.3 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA82048.1 - 0.0099 15.4 0.1 0.027 14.1 0.1 1.7 1 0 0 1 1 1 1 Kelch motif Saccharop_dh_N PF04455.12 EFA82048.1 - 0.01 16.2 0.6 0.036 14.5 0.6 2.0 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Kelch_4 PF13418.6 EFA82048.1 - 0.079 13.0 0.1 1 9.4 0.1 2.7 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA82048.1 - 0.092 12.8 0.8 0.31 11.1 0.8 1.9 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 EFA82050.1 - 7.6e-16 57.8 6.1 1.9e-10 40.7 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA82050.1 - 1.2e-05 24.7 1.2 0.0012 18.4 0.2 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 EFA82050.1 - 0.005 16.8 2.1 0.22 11.6 0.1 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain zf-B_box PF00643.24 EFA82050.1 - 0.038 14.1 13.7 0.096 12.9 13.7 1.6 1 0 0 1 1 1 0 B-box zinc finger Kelch_2 PF07646.15 EFA82050.1 - 0.078 13.0 0.1 0.33 11.0 0.1 2.1 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 EFA82050.1 - 1.8 8.6 6.6 0.16 12.0 0.7 2.4 2 0 0 2 2 2 0 Kelch motif DUF4637 PF15470.6 EFA82050.1 - 1.9 8.2 4.3 3.2 7.5 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) ORC2 PF04084.14 EFA82051.1 - 2.5e-76 256.8 7.9 3.8e-76 256.1 7.9 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 CENP-B_dimeris PF09026.10 EFA82051.1 - 0.0038 17.6 5.2 0.19 12.1 0.0 2.6 2 0 0 2 2 2 2 Centromere protein B dimerisation domain PLDc_2 PF13091.6 EFA82052.1 - 4.7e-16 58.9 0.0 2e-07 31.0 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFA82052.1 - 1.8e-06 27.9 0.1 0.13 12.4 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif DUF4711 PF15829.5 EFA82052.1 - 0.41 10.6 0.0 0.41 10.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4711) Glycophorin_A PF01102.18 EFA82053.1 - 0.078 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Glycophorin A eIF2_C PF09173.11 EFA82054.1 - 3.2e-26 91.4 0.2 6.6e-26 90.4 0.2 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EFA82054.1 - 2.4e-14 53.4 0.3 7.1e-11 42.0 0.1 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFA82054.1 - 2e-08 34.5 0.1 7.5e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 EFA82054.1 - 0.0013 18.7 0.1 0.004 17.1 0.1 1.9 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EFA82054.1 - 0.002 18.0 2.5 0.0026 17.7 0.3 2.1 3 0 0 3 3 3 1 RsgA GTPase Kelch_6 PF13964.6 EFA82058.1 - 0.00045 20.4 0.3 0.21 12.0 0.0 2.7 1 1 1 2 2 2 2 Kelch motif DUF3958 PF13125.6 EFA82059.1 - 0.0095 16.1 2.9 0.017 15.3 2.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3958) Alpha-2-MRAP_C PF06401.11 EFA82059.1 - 0.011 15.7 4.8 0.011 15.7 4.8 1.7 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain TMEM95 PF15203.6 EFA82059.1 - 0.11 12.2 0.5 0.15 11.7 0.5 1.3 1 0 0 1 1 1 0 TMEM95 family AAA_11 PF13086.6 EFA82059.1 - 0.34 10.7 3.6 0.39 10.5 3.6 1.0 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 EFA82059.1 - 2 8.6 10.5 2.8 8.1 10.5 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family GRIP PF01465.20 EFA82060.1 - 0.008 16.1 0.0 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 GRIP domain SAM_PNT PF02198.16 EFA82062.1 - 2.3e-06 27.5 0.1 5e-06 26.4 0.1 1.5 1 1 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PHB_depo_C PF06850.11 EFA82062.1 - 0.16 11.4 0.0 14 5.1 0.0 2.1 2 0 0 2 2 2 0 PHB de-polymerase C-terminus Kelch_6 PF13964.6 EFA82063.1 - 2e-13 50.1 11.4 7.7e-07 29.2 0.2 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFA82063.1 - 0.00015 21.2 2.0 0.02 14.4 0.0 3.3 3 0 0 3 3 3 1 Kelch motif zf-B_box PF00643.24 EFA82063.1 - 0.001 19.2 11.4 0.0023 18.1 11.4 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA82063.1 - 0.014 15.4 5.5 2.5 8.2 0.2 4.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Saccharop_dh_N PF04455.12 EFA82063.1 - 0.046 14.1 0.6 0.15 12.5 0.1 2.1 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region Kelch_2 PF07646.15 EFA82063.1 - 0.13 12.3 0.3 1.7 8.7 0.1 2.8 2 0 0 2 2 2 0 Kelch motif DUF489 PF04356.12 EFA82063.1 - 1.5 8.8 4.5 2.2 8.3 2.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Aldolase_II PF00596.21 EFA82064.1 - 1.8e-10 41.1 0.0 2.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain NP1-WLL PF11733.8 EFA82064.1 - 0.22 11.3 0.1 0.73 9.6 0.0 1.7 1 1 1 2 2 2 0 Non-capsid protein NP1 DUF1811 PF08838.10 EFA82065.1 - 0.11 12.7 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) DEAD PF00270.29 EFA82065.1 - 0.13 12.0 0.1 0.52 10.0 0.0 1.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase Kelch_6 PF13964.6 EFA82066.1 - 2.3e-16 59.4 3.2 7.9e-08 32.3 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFA82066.1 - 0.0001 21.8 1.2 0.023 14.3 0.0 3.3 3 0 0 3 3 3 1 Kelch motif zf-B_box PF00643.24 EFA82066.1 - 0.0029 17.7 12.3 0.0061 16.7 12.3 1.5 1 0 0 1 1 1 1 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82066.1 - 0.019 15.4 0.2 0.076 13.4 0.2 2.0 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region DUF1217 PF06748.12 EFA82066.1 - 0.029 14.4 3.3 0.048 13.7 2.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) Kelch_4 PF13418.6 EFA82066.1 - 0.065 13.2 4.9 20 5.3 0.2 4.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA82066.1 - 0.15 12.0 4.5 1.8 8.7 0.6 3.0 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 EFA82066.1 - 0.18 11.8 1.3 2.5 8.2 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Ribosomal_S4e PF00900.20 EFA82068.1 - 0.039 13.9 0.1 0.053 13.4 0.1 1.3 1 0 0 1 1 1 0 Ribosomal family S4e Ank_2 PF12796.7 EFA82070.1 - 4.6e-27 94.4 10.0 2.6e-06 27.9 0.8 6.0 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA82070.1 - 1.1e-21 76.6 10.2 0.06 13.7 0.1 10.8 4 3 7 11 11 11 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA82070.1 - 6.9e-21 74.3 9.4 0.055 14.1 0.0 8.9 4 3 5 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82070.1 - 1.5e-14 52.6 12.7 1.2 9.9 0.0 10.9 10 2 2 12 12 12 4 Ankyrin repeat DUF5049 PF16468.5 EFA82070.1 - 0.0048 16.8 0.2 8.6 6.4 0.1 4.4 6 0 0 6 6 6 1 Domain of unknown function (DUF5049) DUF3447 PF11929.8 EFA82070.1 - 0.0092 15.9 12.3 1.2 9.1 0.0 4.9 4 2 1 5 5 5 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA82070.1 - 0.42 11.1 1.4 6.4e+02 1.1 0.0 5.9 7 1 0 7 7 7 0 Ankyrin repeat Kelch_6 PF13964.6 EFA82071.1 - 3.9e-15 55.5 8.1 5.4e-09 36.0 0.2 4.6 3 1 2 5 5 5 2 Kelch motif DUF1217 PF06748.12 EFA82071.1 - 0.0024 17.9 2.8 0.0055 16.8 2.5 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1217) zf-B_box PF00643.24 EFA82071.1 - 0.0051 16.9 10.8 0.011 15.8 10.8 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA82071.1 - 0.016 14.8 0.8 0.068 12.8 0.1 2.5 2 0 0 2 2 2 0 Kelch motif Saccharop_dh_N PF04455.12 EFA82071.1 - 0.026 14.9 1.1 0.082 13.3 0.2 2.3 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region Hfq PF17209.3 EFA82071.1 - 0.041 13.5 0.3 0.11 12.2 0.3 1.6 1 0 0 1 1 1 0 Hfq protein Kelch_4 PF13418.6 EFA82071.1 - 0.058 13.4 0.6 2.6 8.1 0.4 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Pox_D5 PF03288.16 EFA82072.1 - 0.11 13.0 0.2 0.12 12.8 0.2 1.1 1 0 0 1 1 1 0 Poxvirus D5 protein-like Kelch_6 PF13964.6 EFA82074.1 - 9.2e-15 54.3 3.9 3e-09 36.8 0.1 4.3 4 0 0 4 4 4 2 Kelch motif zf-B_box PF00643.24 EFA82074.1 - 0.00054 20.1 10.5 0.0012 18.9 10.5 1.5 1 0 0 1 1 1 1 B-box zinc finger DUF1217 PF06748.12 EFA82074.1 - 0.0056 16.7 2.4 0.0056 16.7 2.4 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1217) Saccharop_dh_N PF04455.12 EFA82074.1 - 0.0075 16.7 0.7 0.02 15.3 0.1 2.0 2 0 0 2 2 2 1 LOR/SDH bifunctional enzyme conserved region Kelch_1 PF01344.25 EFA82074.1 - 0.047 13.3 0.3 0.17 11.5 0.3 1.9 1 0 0 1 1 1 0 Kelch motif Kelch_2 PF07646.15 EFA82074.1 - 0.13 12.3 0.1 0.89 9.6 0.1 2.4 1 0 0 1 1 1 0 Kelch motif DUF3439 PF11921.8 EFA82074.1 - 0.57 10.2 7.1 1 9.4 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) DUF3958 PF13125.6 EFA82074.1 - 0.92 9.7 7.5 0.31 11.3 3.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) RNA_pol_Rpb2_6 PF00562.28 EFA82075.1 - 1.1e-121 406.6 0.0 1.5e-121 406.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFA82075.1 - 1.8e-51 174.5 0.3 2.7e-51 174.0 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EFA82075.1 - 7.8e-32 109.5 0.9 1.6e-31 108.5 0.2 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EFA82075.1 - 1.5e-25 89.3 0.4 3.6e-25 88.0 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EFA82075.1 - 7.7e-25 87.6 0.5 1.4e-24 86.8 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EFA82075.1 - 9.9e-20 70.5 0.0 2e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EFA82075.1 - 4.7e-09 36.7 4.0 6.1e-09 36.3 1.5 2.5 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 5 TFIIA PF03153.13 EFA82076.1 - 4.1e-49 168.7 13.2 1.7e-26 94.2 7.6 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 EFA82076.1 - 6.1 5.4 7.7 7.9 5.0 7.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_C50 PF03568.17 EFA82077.1 - 1.3e-74 251.7 1.1 1.3e-74 251.7 1.1 5.0 6 1 0 6 6 6 1 Peptidase family C50 TPR_2 PF07719.17 EFA82077.1 - 6.5e-07 29.0 4.2 0.16 12.2 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA82077.1 - 8.8e-06 25.9 5.0 0.0017 18.6 0.3 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat CHAT PF12770.7 EFA82077.1 - 1.4e-05 24.7 0.0 6.3e-05 22.5 0.0 2.0 1 1 1 2 2 2 1 CHAT domain IQCJ-SCHIP1 PF15157.6 EFA82077.1 - 0.0073 16.2 3.0 0.048 13.5 3.0 2.5 1 0 0 1 1 1 1 Fusion protein IQCJ-SCHIP1 with IQ-like motif TPR_1 PF00515.28 EFA82077.1 - 0.013 15.3 4.5 1.5 8.8 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TRAP_alpha PF03896.16 EFA82077.1 - 0.35 10.0 10.9 1 8.5 10.9 1.7 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TPR_8 PF13181.6 EFA82077.1 - 0.39 11.0 11.2 25 5.4 0.1 5.3 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA82077.1 - 1 9.5 7.1 40 4.5 0.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat SUIM_assoc PF16619.5 EFA82077.1 - 1.3 9.2 16.6 0.039 14.0 3.6 3.7 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 FYDLN_acid PF09538.10 EFA82077.1 - 4.8 7.9 19.6 4.3 8.1 14.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Kelch_6 PF13964.6 EFA82078.1 - 3.2e-16 59.0 7.8 2e-09 37.4 0.1 5.0 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA82078.1 - 0.022 14.9 16.1 0.054 13.7 16.1 1.6 1 0 0 1 1 1 0 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82078.1 - 0.028 14.8 0.5 0.11 13.0 0.1 2.2 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region Kelch_4 PF13418.6 EFA82078.1 - 0.039 14.0 2.8 1.4 9.0 0.1 3.7 4 0 0 4 4 4 0 Galactose oxidase, central domain DUF1217 PF06748.12 EFA82078.1 - 0.043 13.9 2.7 0.053 13.6 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1217) Kelch_1 PF01344.25 EFA82078.1 - 0.054 13.1 0.3 0.31 10.7 0.0 2.5 3 0 0 3 3 3 0 Kelch motif Cep57_CLD PF14073.6 EFA82078.1 - 0.074 13.1 2.8 0.18 11.8 2.8 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 GM_CSF PF01109.17 EFA82078.1 - 0.3 11.2 6.2 0.07 13.3 0.5 2.8 1 1 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor Kelch_6 PF13964.6 EFA82079.1 - 1.5e-07 31.5 4.7 0.0009 19.4 0.1 3.8 3 1 1 4 4 4 2 Kelch motif OLF PF02191.16 EFA82079.1 - 0.0042 16.6 4.4 0.045 13.3 0.9 2.4 1 1 1 2 2 2 2 Olfactomedin-like domain zf-B_box PF00643.24 EFA82080.1 - 0.7 10.1 20.2 0.11 12.6 16.1 1.8 2 0 0 2 2 2 0 B-box zinc finger DUF1217 PF06748.12 EFA82080.1 - 1.2 9.1 6.5 0.47 10.5 0.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1217) Kelch_6 PF13964.6 EFA82081.1 - 2.2e-18 65.8 2.0 2.4e-10 40.3 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EFA82081.1 - 0.008 16.2 1.9 0.99 9.5 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA82081.1 - 0.018 14.6 0.0 0.068 12.8 0.0 2.0 1 0 0 1 1 1 0 Kelch motif zf-B_box PF00643.24 EFA82081.1 - 0.11 12.7 14.1 0.24 11.6 14.1 1.5 1 0 0 1 1 1 0 B-box zinc finger NHL PF01436.21 EFA82081.1 - 0.33 11.1 1.8 33 4.8 0.1 2.8 3 0 0 3 3 3 0 NHL repeat TFIIE-A_C PF11521.8 EFA82082.1 - 0.29 11.4 3.3 0.32 11.3 3.3 1.0 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Kelch_6 PF13964.6 EFA82083.1 - 1.5e-14 53.7 5.4 2.7e-09 37.0 0.1 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA82083.1 - 0.0017 17.9 0.1 0.013 15.1 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 EFA82083.1 - 0.013 15.5 0.1 1.1 9.3 0.0 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA82083.1 - 0.05 13.8 15.3 0.15 12.2 15.3 1.8 1 0 0 1 1 1 0 B-box zinc finger Kelch_2 PF07646.15 EFA82083.1 - 0.059 13.4 0.6 0.27 11.3 0.2 2.4 2 0 0 2 2 2 0 Kelch motif GM_CSF PF01109.17 EFA82083.1 - 0.076 13.2 0.2 0.076 13.2 0.2 2.3 2 1 1 3 3 3 0 Granulocyte-macrophage colony-stimulating factor DUF1217 PF06748.12 EFA82083.1 - 0.22 11.5 4.4 0.052 13.6 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1217) Kelch_6 PF13964.6 EFA82086.1 - 8.7e-15 54.4 3.7 5.4e-09 36.0 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA82086.1 - 0.0037 16.8 0.0 0.014 14.9 0.0 2.0 2 0 0 2 2 2 1 Kelch motif Saccharop_dh_N PF04455.12 EFA82086.1 - 0.01 16.2 0.1 0.035 14.5 0.1 1.9 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region DUF1217 PF06748.12 EFA82086.1 - 0.017 15.2 2.0 0.025 14.6 1.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) zf-B_box PF00643.24 EFA82086.1 - 0.017 15.2 12.1 0.017 15.2 12.1 1.9 2 0 0 2 2 2 0 B-box zinc finger NHL PF01436.21 EFA82086.1 - 2.5 8.3 7.3 0.93 9.7 0.2 3.0 3 0 0 3 3 3 0 NHL repeat Kelch_6 PF13964.6 EFA82087.1 - 2.9e-15 55.9 4.8 5.9e-10 39.1 0.0 4.8 5 0 0 5 5 5 2 Kelch motif DUF1217 PF06748.12 EFA82087.1 - 0.0074 16.3 3.5 0.016 15.3 2.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1217) Saccharop_dh_N PF04455.12 EFA82087.1 - 0.0085 16.5 0.1 0.037 14.4 0.1 2.1 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Kelch_1 PF01344.25 EFA82087.1 - 0.0091 15.6 0.1 0.093 12.3 0.0 2.5 2 0 0 2 2 2 1 Kelch motif zf-B_box PF00643.24 EFA82087.1 - 0.012 15.8 14.1 0.012 15.8 14.1 2.2 2 0 0 2 2 2 0 B-box zinc finger EGF_2 PF07974.13 EFA82088.1 - 0.0031 17.9 10.8 0.0031 17.9 10.8 1.9 2 0 0 2 2 2 1 EGF-like domain EGF_Tenascin PF18720.1 EFA82088.1 - 0.0033 17.4 7.7 0.0072 16.4 7.7 1.5 1 0 0 1 1 1 1 Tenascin EGF domain VSP PF03302.13 EFA82088.1 - 0.028 13.3 0.3 0.05 12.5 0.3 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein MHC2-interact PF09307.10 EFA82088.1 - 0.11 12.5 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 CLIP, MHC2 interacting EGF PF00008.27 EFA82088.1 - 0.39 11.1 9.3 0.82 10.0 9.3 1.6 1 0 0 1 1 1 0 EGF-like domain 7tm_1 PF00001.21 EFA82090.1 - 0.02 14.2 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF1599 PF07659.11 EFA82090.1 - 0.17 12.4 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 Nucleotide modification associated domain 1 EGF_2 PF07974.13 EFA82091.1 - 0.00016 21.9 10.2 0.00037 20.8 10.2 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA82091.1 - 0.031 14.3 4.9 0.064 13.3 4.9 1.5 1 0 0 1 1 1 0 Tenascin EGF domain GREB1 PF15782.5 EFA82091.1 - 0.45 7.6 17.0 0.61 7.1 17.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer EGF PF00008.27 EFA82091.1 - 1.9 8.9 9.5 4 7.8 9.5 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA82092.1 - 0.00018 21.8 10.2 0.00035 20.9 10.2 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA82092.1 - 0.029 14.4 4.9 0.06 13.4 4.9 1.5 1 0 0 1 1 1 0 Tenascin EGF domain CBM49 PF09478.10 EFA82092.1 - 0.34 11.3 0.1 0.34 11.3 0.1 3.8 4 0 0 4 4 4 0 Carbohydrate binding domain CBM49 FAM199X PF15814.5 EFA82092.1 - 0.95 8.5 4.6 2.1 7.3 4.6 1.5 1 0 0 1 1 1 0 Protein family FAM199X EGF PF00008.27 EFA82092.1 - 1.9 8.9 9.5 3.7 7.9 9.5 1.5 1 0 0 1 1 1 0 EGF-like domain Tcf25 PF04910.14 EFA82093.1 - 9.4e-85 284.8 1.8 9.4e-85 284.8 1.8 1.9 2 0 0 2 2 2 1 Transcriptional repressor TCF25 DLIC PF05783.11 EFA82094.1 - 4.4 6.0 6.0 5.8 5.6 6.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) MtN3_slv PF03083.16 EFA82095.1 - 1.2e-12 47.7 13.7 2.4e-12 46.7 4.0 2.7 3 1 0 3 3 3 2 Sugar efflux transporter for intercellular exchange Prefoldin PF02996.17 EFA82096.1 - 5.8e-22 77.8 1.6 1.6e-21 76.4 0.5 1.9 1 1 1 2 2 2 1 Prefoldin subunit CdvA PF18822.1 EFA82096.1 - 0.014 15.2 1.8 0.23 11.3 0.3 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain CK2S PF15011.6 EFA82096.1 - 0.019 14.9 0.1 0.08 12.8 0.0 1.8 2 0 0 2 2 2 0 Casein Kinase 2 substrate SIMPL PF04402.14 EFA82096.1 - 0.07 13.6 1.4 0.088 13.2 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF541) Coiled PF05710.12 EFA82097.1 - 0.022 15.6 6.8 0.025 15.4 6.8 1.1 1 0 0 1 1 1 0 Coiled coil DUF1731 PF08338.11 EFA82098.1 - 2.5e-16 59.2 0.0 2.9e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) SLT PF01464.20 EFA82099.1 - 3.7e-11 42.7 0.0 5.9e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Lys PF00062.20 EFA82099.1 - 0.00073 19.8 3.2 0.007 16.6 3.2 2.0 1 1 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family PALP PF00291.25 EFA82100.1 - 3.5e-74 249.9 0.1 4e-74 249.7 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Actin PF00022.19 EFA82101.1 - 2.6e-125 418.2 0.0 1.5e-124 415.8 0.0 1.8 1 1 0 1 1 1 1 Actin Actin_micro PF17003.5 EFA82101.1 - 0.029 13.6 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 Putative actin-like family Ribosomal_S7e PF01251.18 EFA82102.1 - 5.2e-78 261.0 6.0 6e-78 260.8 6.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Kelch_6 PF13964.6 EFA82103.1 - 2.4e-15 56.2 6.1 2.4e-09 37.1 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA82103.1 - 0.0018 17.8 0.1 0.0093 15.5 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Saccharop_dh_N PF04455.12 EFA82103.1 - 0.024 15.1 0.1 0.091 13.2 0.1 2.1 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Kelch_4 PF13418.6 EFA82103.1 - 0.029 14.4 0.6 1.4 9.0 0.1 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA82103.1 - 0.031 14.4 14.9 0.092 12.9 14.9 1.7 1 0 0 1 1 1 0 B-box zinc finger DUF1217 PF06748.12 EFA82103.1 - 0.051 13.6 0.7 0.12 12.4 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) Kelch_5 PF13854.6 EFA82103.1 - 0.3 11.1 1.4 0.64 10.1 0.4 2.2 2 0 0 2 2 2 0 Kelch motif Acyl_transf_1 PF00698.21 EFA82104.1 - 2.3e-19 70.1 0.0 3.2e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain SRP1_TIP1 PF00660.17 EFA82104.1 - 0.063 13.3 0.8 34 4.6 0.0 3.4 3 0 0 3 3 3 0 Seripauperin and TIP1 family Kelch_6 PF13964.6 EFA82105.1 - 8.4e-15 54.5 7.4 4e-10 39.6 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA82105.1 - 0.0032 17.0 0.3 0.024 14.2 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Saccharop_dh_N PF04455.12 EFA82105.1 - 0.004 17.5 0.2 0.0097 16.3 0.2 1.6 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region DUF1217 PF06748.12 EFA82105.1 - 0.077 13.0 3.9 0.079 13.0 1.0 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1217) Kelch_4 PF13418.6 EFA82105.1 - 0.76 9.8 2.4 5 7.2 0.1 3.5 4 0 0 4 4 4 0 Galactose oxidase, central domain Pkinase PF00069.25 EFA82107.1 - 1e-77 261.1 0.0 1.2e-77 260.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82107.1 - 2.1e-34 119.0 0.0 3.2e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFA82107.1 - 1.1e-08 34.4 0.0 2.1e-07 30.2 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFA82107.1 - 0.00034 20.6 0.0 0.0052 16.7 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFA82107.1 - 0.00083 18.5 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EFA82107.1 - 0.0022 17.4 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFA82107.1 - 0.01 15.2 0.1 0.11 11.8 0.0 2.3 1 1 1 2 2 2 0 Kinase-like FTA2 PF13095.6 EFA82107.1 - 0.091 12.4 0.2 0.78 9.3 0.1 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DIM PF08194.12 EFA82109.1 - 0.48 10.7 1.9 0.89 9.8 1.9 1.4 1 0 0 1 1 1 0 DIM protein TatD_DNase PF01026.21 EFA82111.1 - 2.6e-48 164.6 0.1 3.1e-48 164.4 0.1 1.0 1 0 0 1 1 1 1 TatD related DNase XYPPX PF02162.17 EFA82112.1 - 0.0045 16.8 18.1 0.0045 16.8 18.1 3.4 3 0 0 3 3 3 2 XYPPX repeat (two copies) DnaJ_CXXCXGXG PF00684.19 EFA82112.1 - 0.25 11.7 16.4 1.4 9.3 16.2 2.2 1 1 0 1 1 1 0 DnaJ central domain Anti-TRAP PF15777.5 EFA82112.1 - 1.1 9.3 11.1 0.55 10.2 4.3 2.4 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Kelch_6 PF13964.6 EFA82113.1 - 4.6e-17 61.6 2.6 2.4e-10 40.3 0.0 4.1 3 0 0 3 3 3 2 Kelch motif Saccharop_dh_N PF04455.12 EFA82113.1 - 0.0034 17.7 2.0 0.077 13.4 0.1 2.7 2 0 0 2 2 2 1 LOR/SDH bifunctional enzyme conserved region zf-B_box PF00643.24 EFA82113.1 - 0.0076 16.4 8.7 0.0076 16.4 8.7 1.9 2 0 0 2 2 2 1 B-box zinc finger DUF3958 PF13125.6 EFA82113.1 - 0.016 15.4 5.6 0.079 13.2 5.6 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) Kelch_1 PF01344.25 EFA82113.1 - 0.033 13.8 0.0 0.13 11.9 0.0 2.0 1 0 0 1 1 1 0 Kelch motif zf-C3HC4 PF00097.25 EFA82113.1 - 0.042 13.7 9.1 0.13 12.1 9.1 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Nup54 PF13874.6 EFA82113.1 - 0.17 12.0 4.3 0.4 10.8 4.1 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Tipalpha PF16753.5 EFA82113.1 - 0.23 11.3 8.9 0.29 11.0 6.7 2.3 1 1 1 2 2 2 0 TNF-alpha-Inducing protein of Helicobacter zf-RING_5 PF14634.6 EFA82113.1 - 0.24 11.4 8.3 0.58 10.2 8.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain DUF4407 PF14362.6 EFA82113.1 - 0.26 10.6 3.2 0.45 9.8 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CobU PF02283.16 EFA82113.1 - 0.5 9.9 3.1 0.37 10.3 0.9 1.9 2 1 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Kelch_6 PF13964.6 EFA82114.1 - 4.8e-16 58.4 4.4 7.6e-09 35.5 0.0 4.9 6 0 0 6 6 6 2 Kelch motif zf-B_box PF00643.24 EFA82114.1 - 0.0078 16.4 13.4 0.021 15.0 13.4 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA82114.1 - 0.0093 15.5 0.1 0.054 13.1 0.0 2.4 2 0 0 2 2 2 1 Kelch motif NHL PF01436.21 EFA82114.1 - 0.069 13.2 3.3 0.78 9.9 0.2 3.4 3 0 0 3 3 3 0 NHL repeat Kelch_2 PF07646.15 EFA82114.1 - 0.085 12.9 0.1 0.91 9.6 0.0 2.8 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 EFA82114.1 - 0.26 11.3 7.8 4.4 7.4 0.1 3.7 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF4637 PF15470.6 EFA82114.1 - 0.45 10.2 4.0 0.98 9.1 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF2076 PF09849.9 EFA82115.1 - 0.032 14.3 6.9 0.035 14.2 6.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SNF2_N PF00176.23 EFA82116.1 - 1.1e-30 106.6 0.0 1.1e-28 100.0 0.0 3.2 2 1 1 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA82116.1 - 2.5e-15 56.8 1.1 9.5e-15 54.9 1.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SR-25 PF10500.9 EFA82116.1 - 0.0032 17.1 4.1 0.0032 17.1 4.1 2.5 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Apc15p PF05841.11 EFA82116.1 - 0.029 15.2 0.9 0.029 15.2 0.9 5.1 5 1 0 6 6 6 0 Apc15p protein FTA2 PF13095.6 EFA82116.1 - 0.43 10.2 7.4 4.3 6.9 0.6 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 7tm_3 PF00003.22 EFA82117.1 - 2.9e-39 135.2 17.6 2.9e-39 135.2 17.6 1.4 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA82117.1 - 2.8e-13 49.5 0.4 4.1e-13 49.0 0.4 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like LRR_4 PF12799.7 EFA82119.1 - 1.5e-17 63.4 25.8 8.5e-09 35.6 1.3 4.4 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA82119.1 - 1.7e-17 62.9 26.6 3.5e-08 33.1 1.4 4.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 EFA82119.1 - 4.1e-10 39.4 13.2 4.3e-05 23.1 1.7 2.9 1 1 2 3 3 3 2 Leucine-rich repeat Syntaxin_2 PF14523.6 EFA82119.1 - 0.00047 20.5 5.5 0.069 13.5 0.3 2.8 2 1 0 2 2 2 2 Syntaxin-like protein LRR_1 PF00560.33 EFA82119.1 - 0.013 15.9 17.4 0.73 10.6 0.1 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat DUF5624 PF18538.1 EFA82119.1 - 0.014 15.5 0.4 0.049 13.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) LRR_6 PF13516.6 EFA82119.1 - 0.023 14.7 12.5 7.5 6.9 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich repeat EXOSC1 PF10447.9 EFA82119.1 - 0.13 12.9 0.0 0.32 11.6 0.0 1.6 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 LRR_2 PF07723.13 EFA82119.1 - 0.63 10.8 2.9 5.7 7.8 0.1 3.1 3 0 0 3 3 3 0 Leucine Rich Repeat Epimerase PF01370.21 EFA82120.1 - 3.8e-14 52.8 0.0 4.3e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA82120.1 - 2.7e-12 46.3 0.0 3.3e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFA82120.1 - 2.2e-08 34.2 0.0 2.4e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFA82120.1 - 2.3e-07 30.5 0.0 4.6e-07 29.5 0.0 1.5 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFA82120.1 - 3.4e-07 29.7 0.2 0.019 14.1 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EFA82120.1 - 7.5e-07 28.6 0.0 1.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFA82120.1 - 5.5e-06 25.7 0.0 8.9e-06 25.0 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 EFA82120.1 - 2.1e-05 24.2 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EFA82120.1 - 9e-05 22.5 0.0 0.00015 21.7 0.0 1.4 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EFA82120.1 - 0.0032 16.9 0.0 0.0058 16.1 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase HydF_tetramer PF18133.1 EFA82120.1 - 0.014 15.2 0.1 0.02 14.7 0.1 1.2 1 0 0 1 1 1 0 Hydrogen maturase F tetramerization domain Sacchrp_dh_NADP PF03435.18 EFA82120.1 - 0.024 14.9 0.0 0.031 14.6 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EFA82120.1 - 0.034 14.6 0.0 0.046 14.1 0.0 1.2 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 EFA82120.1 - 0.037 14.1 0.2 0.19 11.8 0.2 1.9 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFA82120.1 - 0.078 13.2 0.0 0.095 12.9 0.0 1.1 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFA82120.1 - 0.11 13.1 0.0 0.19 12.4 0.0 1.5 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UCH PF00443.29 EFA82122.1 - 2.7e-39 135.2 6.2 2.7e-39 135.2 6.2 4.3 4 1 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA82122.1 - 4.9e-22 78.9 5.8 4.9e-22 78.9 5.8 4.1 4 2 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase Cnd1 PF12717.7 EFA82122.1 - 0.11 12.5 0.1 0.11 12.5 0.1 3.7 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 EGF_2 PF07974.13 EFA82123.1 - 0.5 10.8 14.2 1.1 9.7 14.2 1.6 1 0 0 1 1 1 0 EGF-like domain PH PF00169.29 EFA82124.1 - 1.3e-13 51.3 4.9 2.2e-13 50.6 0.4 3.6 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 EFA82124.1 - 0.00011 22.6 0.5 0.00011 22.6 0.5 3.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EFA82124.1 - 0.00042 20.5 0.2 0.0014 18.9 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain TIG PF01833.24 EFA82124.1 - 0.00074 19.5 1.9 0.00074 19.5 1.9 5.1 5 1 0 5 5 5 1 IPT/TIG domain EGF_2 PF07974.13 EFA82124.1 - 0.97 9.9 14.2 2 8.8 14.2 1.6 1 0 0 1 1 1 0 EGF-like domain RasGAP PF00616.19 EFA82125.1 - 1.7e-32 112.9 4.3 3.9e-29 101.9 0.0 4.2 3 1 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EFA82125.1 - 3.6e-20 72.5 1.1 2.2e-19 70.0 0.5 2.8 3 0 0 3 3 3 1 Divergent CRAL/TRIO domain TBK1_CCD1 PF18394.1 EFA82125.1 - 0.0074 15.9 7.1 0.29 10.6 0.1 3.6 3 1 1 4 4 4 2 TANK-binding kinase 1 coiled-coil domain 1 MOR2-PAG1_C PF14225.6 EFA82125.1 - 0.049 13.5 0.2 0.049 13.5 0.2 3.5 3 0 0 3 3 3 0 Cell morphogenesis C-terminal HEAT PF02985.22 EFA82125.1 - 0.093 13.0 2.5 4.5 7.8 0.1 4.6 3 0 0 3 3 3 0 HEAT repeat eIF-5_eIF-2B PF01873.17 EFA82125.1 - 0.11 12.3 0.0 0.62 10.0 0.0 2.3 1 0 0 1 1 1 0 Domain found in IF2B/IF5 UQ_con PF00179.26 EFA82126.1 - 7.8e-47 158.4 1.9 1.4e-46 157.6 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFA82126.1 - 0.0017 18.1 0.0 0.0028 17.4 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFA82126.1 - 0.0057 16.9 1.1 0.011 16.0 1.0 1.8 1 1 0 1 1 1 1 RWD domain RhoGEF PF00621.20 EFA82128.1 - 1.3e-44 152.6 0.2 1.3e-44 152.6 0.2 2.5 3 1 0 3 3 3 1 RhoGEF domain Acetyltransf_10 PF13673.7 EFA82130.1 - 2e-15 56.8 0.1 2.4e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA82130.1 - 9.4e-07 29.2 0.3 1.3e-06 28.8 0.3 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA82130.1 - 1.6e-05 25.1 0.2 1.8e-05 24.9 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PanZ PF12568.8 EFA82130.1 - 0.038 13.7 0.0 0.05 13.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ FR47 PF08445.10 EFA82130.1 - 0.068 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein DUF5432 PF17497.2 EFA82131.1 - 0.42 10.7 1.8 12 6.1 0.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5432) SKICH PF17751.1 EFA82132.1 - 1.3e-16 61.0 1.7 1.6e-05 25.4 0.1 3.9 3 0 0 3 3 3 3 SKICH domain HECW_N PF16562.5 EFA82132.1 - 8.3e-13 48.2 0.3 4.3e-05 23.3 0.0 3.6 3 0 0 3 3 3 3 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 FNIP PF05725.12 EFA82132.1 - 1.1e-10 41.5 32.2 3e-07 30.5 0.3 6.5 6 1 2 8 8 8 5 FNIP Repeat FNIP PF05725.12 EFA82133.1 - 1.7e-27 95.3 51.6 2.7e-08 33.9 0.1 10.5 10 2 1 11 11 11 7 FNIP Repeat F-box_5 PF18511.1 EFA82133.1 - 0.044 13.3 0.3 0.41 10.2 0.0 2.5 3 0 0 3 3 3 0 F-box FNIP PF05725.12 EFA82134.1 - 4.8e-08 33.0 3.2 0.0009 19.4 0.0 4.8 1 1 4 5 5 5 5 FNIP Repeat OHCU_decarbox PF09349.10 EFA82135.1 - 1.3e-36 126.5 0.0 1.9e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 OHCU decarboxylase Amidohydro_1 PF01979.20 EFA82135.1 - 2.9e-06 26.9 0.0 6.7e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFA82135.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family EcKinase PF02958.20 EFA82136.1 - 1.6e-08 34.2 0.0 0.0081 15.5 0.0 3.5 3 1 0 3 3 3 3 Ecdysteroid kinase DUF1679 PF07914.11 EFA82136.1 - 1.1e-05 24.5 0.1 0.046 12.6 0.0 2.7 4 0 0 4 4 4 2 Protein of unknown function (DUF1679) APH PF01636.23 EFA82136.1 - 5.2e-05 23.3 0.1 0.00015 21.8 0.1 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Ank_2 PF12796.7 EFA82137.1 - 2.9e-38 130.3 11.4 4.8e-10 39.9 0.0 7.8 4 2 2 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA82137.1 - 6.6e-29 99.6 4.8 6e-05 23.2 0.0 9.8 7 3 3 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82137.1 - 5.8e-24 81.6 8.8 0.00091 19.5 0.0 11.7 13 0 0 13 13 13 5 Ankyrin repeat Ank_4 PF13637.6 EFA82137.1 - 1.4e-21 76.5 6.6 8.2e-06 26.3 0.0 8.5 7 2 1 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EFA82137.1 - 1.7e-21 75.6 5.9 0.00052 20.4 0.0 7.6 8 1 1 9 9 9 5 Ankyrin repeat CGI-121 PF08617.10 EFA82137.1 - 0.16 12.1 4.8 0.16 12.1 0.1 3.2 4 0 0 4 4 4 0 Kinase binding protein CGI-121 Baculo_PEP_C PF04513.12 EFA82137.1 - 1.4 8.9 6.5 2.5 8.1 4.6 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SecA_DEAD PF07517.14 EFA82138.1 - 2.3e-51 174.8 0.7 3.9e-51 174.1 0.0 1.7 2 0 0 2 2 2 1 SecA DEAD-like domain SecA_PP_bind PF01043.20 EFA82138.1 - 3.2e-08 34.2 0.2 1.8e-07 31.8 0.2 2.4 1 0 0 1 1 1 1 SecA preprotein cross-linking domain Ank_4 PF13637.6 EFA82138.1 - 0.00019 21.9 0.2 0.04 14.5 0.1 3.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA82138.1 - 0.00022 21.7 0.0 0.012 16.2 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Helicase_C PF00271.31 EFA82138.1 - 0.00066 20.0 1.7 0.0032 17.8 0.1 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Ank_5 PF13857.6 EFA82138.1 - 0.0036 17.6 0.2 0.14 12.5 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82138.1 - 0.0037 17.6 0.5 0.35 11.6 0.1 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFA82138.1 - 0.011 16.1 0.0 1.6 9.3 0.1 3.5 2 0 0 2 2 2 0 Ankyrin repeat RRM_1 PF00076.22 EFA82140.1 - 6.6e-18 64.3 0.1 8.7e-09 35.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) R3H PF01424.22 EFA82140.1 - 6e-12 45.4 0.0 1.2e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 R3H domain SUZ-C PF12901.7 EFA82140.1 - 1.8e-05 24.6 0.1 5.5e-05 23.1 0.1 1.9 1 0 0 1 1 1 1 SUZ-C motif Limkain-b1 PF11608.8 EFA82140.1 - 0.0034 17.4 0.2 0.46 10.6 0.1 3.0 2 1 0 2 2 2 1 Limkain b1 Nup35_RRM_2 PF14605.6 EFA82140.1 - 0.017 15.1 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 EFA82140.1 - 0.043 13.8 0.0 14 5.8 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Amelogenin PF02948.15 EFA82140.1 - 0.29 11.8 1.6 0.39 11.3 0.1 1.9 2 0 0 2 2 2 0 Amelogenin Carbpep_Y_N PF05388.11 EFA82140.1 - 1.7 9.2 5.7 6.1 7.4 5.7 1.9 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide PRESAN PF09687.10 EFA82142.1 - 0.0051 17.4 2.1 0.0094 16.5 2.1 1.3 1 0 0 1 1 1 1 Plasmodium RESA N-terminal MecA PF05389.12 EFA82142.1 - 0.29 10.7 14.0 0.5 10.0 1.5 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) SSP160 PF06933.11 EFA82142.1 - 2 6.5 11.5 3.1 5.9 11.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Cyt-b5 PF00173.28 EFA82144.1 - 4.3e-23 81.2 0.1 6.2e-23 80.7 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain COX2-transmemb PF09125.10 EFA82144.1 - 0.059 13.2 1.0 0.11 12.3 1.0 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane SET PF00856.28 EFA82146.1 - 5.5e-09 36.6 2.2 1.9e-07 31.6 0.7 2.9 2 1 0 2 2 2 1 SET domain Myc_N PF01056.18 EFA82146.1 - 0.0059 16.5 1.8 0.0091 15.9 1.8 1.2 1 0 0 1 1 1 1 Myc amino-terminal region NOA36 PF06524.12 EFA82146.1 - 0.028 13.7 11.1 0.043 13.2 11.1 1.2 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 EFA82146.1 - 0.23 10.7 2.3 0.3 10.2 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 EFA82146.1 - 0.29 10.8 5.2 0.67 9.6 5.2 1.5 1 0 0 1 1 1 0 FAM176 family RNA_pol_3_Rpc31 PF11705.8 EFA82146.1 - 2.5 8.3 10.5 5 7.3 10.5 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2730 PF10805.8 EFA82148.1 - 0.0061 16.6 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2730) Flg_hook PF02120.16 EFA82149.1 - 0.043 13.7 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK PCI PF01399.27 EFA82150.1 - 1.5e-25 89.7 1.8 1.5e-25 89.7 1.8 2.3 2 1 0 2 2 2 1 PCI domain DUF4611 PF15387.6 EFA82151.1 - 5.6 7.3 8.2 10 6.4 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) YL1 PF05764.13 EFA82151.1 - 5.8 6.9 8.1 5.8 7.0 8.1 1.1 1 0 0 1 1 1 0 YL1 nuclear protein CHCH PF06747.13 EFA82152.1 - 9.9e-07 28.7 5.1 1.5e-06 28.2 5.1 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EFA82152.1 - 0.0015 18.5 4.4 0.0026 17.7 4.4 1.4 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 EFA82152.1 - 0.02 15.2 4.3 0.041 14.2 4.3 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 EFA82152.1 - 0.17 12.1 3.2 0.53 10.6 3.2 1.8 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb COX17 PF05051.13 EFA82152.1 - 0.28 11.6 3.2 2.5 8.5 2.6 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Sterol_MT_C PF08498.10 EFA82153.1 - 3.6e-21 75.2 0.0 6.3e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EFA82153.1 - 3.2e-16 59.7 0.0 6.5e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFA82153.1 - 4.4e-15 55.7 0.0 6.5e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EFA82153.1 - 1.7e-14 54.3 0.0 3.9e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA82153.1 - 1.1e-13 51.3 0.0 1.7e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA82153.1 - 8.6e-12 45.2 0.0 1.3e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA82153.1 - 1.8e-06 28.6 0.0 4.5e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA82153.1 - 3.3e-05 23.3 0.0 5.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EFA82153.1 - 4e-05 23.5 0.0 7.2e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 EFA82153.1 - 0.023 14.7 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 EFA82153.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_9 PF08003.11 EFA82153.1 - 0.091 11.7 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MBOAT_2 PF13813.6 EFA82153.1 - 0.095 13.0 0.1 11 6.4 0.0 2.4 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family MTS PF05175.14 EFA82153.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_15 PF09445.10 EFA82153.1 - 0.17 11.4 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RRM_1 PF00076.22 EFA82154.1 - 3.5e-14 52.3 0.1 5.7e-14 51.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 EFA82154.1 - 0.077 13.0 0.0 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Glyco_hydro_35 PF01301.19 EFA82155.1 - 4.4e-101 338.6 1.2 5.9e-101 338.2 1.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EFA82155.1 - 9.6e-11 41.6 0.1 5e-10 39.3 0.1 1.9 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 EFA82155.1 - 0.00013 22.5 8.8 0.0052 17.3 0.1 3.6 4 0 0 4 4 4 2 Beta-galactosidase jelly roll domain Cellulase PF00150.18 EFA82155.1 - 0.064 12.7 0.1 0.2 11.0 0.0 1.9 3 0 0 3 3 3 0 Cellulase (glycosyl hydrolase family 5) DUF2465 PF10239.9 EFA82156.1 - 2e-36 125.9 2.6 2.7e-36 125.5 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) EF-hand_4 PF12763.7 EFA82156.1 - 0.032 14.2 1.9 0.092 12.7 1.9 1.9 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Aim21 PF11489.8 EFA82157.1 - 0.13 11.2 8.7 0.18 10.7 8.7 1.1 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 21 Mucin PF01456.17 EFA82157.1 - 2.5 8.1 24.5 1.5 8.8 7.6 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Ank_2 PF12796.7 EFA82158.1 - 1.8e-21 76.5 3.4 3e-06 27.7 0.0 6.4 3 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA82158.1 - 1.1e-17 63.8 7.6 0.21 11.9 0.0 9.3 6 3 3 9 9 9 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA82158.1 - 5.7e-17 61.8 6.3 0.0008 19.9 0.0 8.5 7 3 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82158.1 - 5.2e-14 51.0 6.5 0.2 12.3 0.1 11.5 12 1 1 13 13 13 2 Ankyrin repeat DUF3447 PF11929.8 EFA82158.1 - 0.027 14.4 13.9 2.1 8.3 0.3 5.5 5 1 1 6 6 6 0 Domain of unknown function (DUF3447) PYRIN PF02758.16 EFA82158.1 - 0.033 14.3 0.1 1.5 9.0 0.1 2.9 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain FNIP PF05725.12 EFA82159.1 - 6.2e-20 71.1 2.6 7.7e-09 35.6 0.1 7.2 5 2 4 9 9 9 4 FNIP Repeat DUF4834 PF16118.5 EFA82159.1 - 0.02 15.8 0.6 0.04 14.9 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CENP-B_dimeris PF09026.10 EFA82159.1 - 3.6 8.0 7.9 0.36 11.3 3.0 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Arf PF00025.21 EFA82160.1 - 2.1e-42 144.5 1.3 2.2e-34 118.4 1.9 3.3 1 1 1 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EFA82160.1 - 1.5e-06 28.5 0.5 5.2e-06 26.7 0.0 2.3 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA82160.1 - 0.00013 21.6 0.4 0.00034 20.2 0.4 1.8 1 1 0 1 1 1 1 Ras family NACHT PF05729.12 EFA82160.1 - 0.0013 18.7 0.1 0.04 13.8 0.1 2.3 1 1 0 1 1 1 1 NACHT domain SRPRB PF09439.10 EFA82160.1 - 0.0027 17.2 0.0 0.014 14.8 0.0 2.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EFA82160.1 - 0.006 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFA82160.1 - 0.048 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EFA82160.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EFA82160.1 - 0.26 11.5 1.2 2.3 8.5 0.2 2.7 2 1 0 2 2 2 0 AAA domain Pkinase_fungal PF17667.1 EFA82161.1 - 4.1 6.1 10.4 0.44 9.3 2.1 2.3 2 0 0 2 2 2 0 Fungal protein kinase Helicase_C PF00271.31 EFA82162.1 - 7.5e-12 45.6 0.5 2.9e-11 43.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFA82162.1 - 0.00077 18.3 0.3 0.0015 17.3 0.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Mucin PF01456.17 EFA82162.1 - 2.2 8.3 11.9 4.2 7.3 11.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Ank_2 PF12796.7 EFA82163.1 - 5.4e-44 148.7 22.1 2.4e-08 34.5 0.6 9.1 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Pyr_redox_2 PF07992.14 EFA82163.1 - 2.5e-36 125.4 0.0 2.5e-36 125.4 0.0 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ank_4 PF13637.6 EFA82163.1 - 3.6e-30 103.9 20.9 0.00017 22.1 0.0 12.3 6 3 7 13 13 13 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA82163.1 - 6.9e-26 90.0 16.4 0.31 11.4 0.0 15.5 6 5 9 15 15 15 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82163.1 - 8.3e-17 59.6 15.9 10 7.0 0.0 15.3 15 2 2 17 17 15 0 Ankyrin repeat Pyr_redox PF00070.27 EFA82163.1 - 1e-14 54.8 0.4 3.5e-10 40.3 0.0 3.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFA82163.1 - 3.3e-05 23.2 0.0 3.3e-05 23.2 0.0 4.1 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFA82163.1 - 0.00017 21.3 0.1 0.7 9.4 0.1 3.4 4 0 0 4 4 4 2 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EFA82163.1 - 0.0013 19.1 2.0 0.24 11.9 0.0 4.2 3 0 0 3 3 3 1 Putative NAD(P)-binding Fez1 PF06818.15 EFA82163.1 - 0.0053 17.2 21.1 0.0053 17.2 21.1 6.7 3 2 3 6 6 4 1 Fez1 ApbA PF02558.16 EFA82163.1 - 0.0091 15.7 0.0 4.4 6.9 0.0 3.6 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EFA82163.1 - 0.011 16.0 0.8 3.5 7.9 0.1 3.3 3 0 0 3 3 2 0 TrkA-N domain NAD_binding_8 PF13450.6 EFA82163.1 - 0.011 15.9 0.0 2.7 8.3 0.0 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FANCI_S2 PF14676.6 EFA82163.1 - 0.013 15.8 0.2 0.013 15.8 0.2 2.8 2 0 0 2 2 1 0 FANCI solenoid 2 Lycopene_cycl PF05834.12 EFA82163.1 - 0.018 14.1 2.5 1.4 7.9 0.0 3.3 3 1 1 4 4 4 0 Lycopene cyclase protein DUF5049 PF16468.5 EFA82163.1 - 0.02 14.8 3.8 6.2 6.8 0.1 4.8 5 1 1 6 6 5 0 Domain of unknown function (DUF5049) Sacchrp_dh_NADP PF03435.18 EFA82163.1 - 0.032 14.5 4.9 0.25 11.6 0.0 4.4 4 0 0 4 4 4 0 Saccharopine dehydrogenase NADP binding domain Ank PF00023.30 EFA82163.1 - 0.074 13.5 8.3 36 5.1 0.0 7.4 7 2 2 9 9 7 0 Ankyrin repeat FlxA PF14282.6 EFA82163.1 - 0.11 12.5 0.1 0.11 12.5 0.1 10.4 6 3 3 10 10 7 0 FlxA-like protein FAD_binding_3 PF01494.19 EFA82163.1 - 0.12 11.6 3.3 0.21 10.8 0.0 2.8 3 0 0 3 3 3 0 FAD binding domain Phostensin_N PF13916.6 EFA82164.1 - 0.037 14.4 1.1 0.037 14.4 1.1 6.5 6 1 0 6 6 6 0 PP1-regulatory protein, Phostensin N-terminal NAR2 PF16974.5 EFA82165.1 - 0.25 10.7 4.1 0.31 10.4 4.1 1.1 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory NST1 PF13945.6 EFA82165.1 - 0.31 11.1 15.3 0.4 10.8 15.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator ALMT PF11744.8 EFA82165.1 - 9.5 4.9 8.5 11 4.8 8.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF5024 PF16427.5 EFA82166.1 - 1 9.8 4.4 1.4 9.3 0.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5024) LPMO_10 PF03067.15 EFA82167.1 - 1.8e-29 103.8 0.3 1.8e-29 103.8 0.3 1.4 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading TMEM154 PF15102.6 EFA82167.1 - 0.078 12.9 8.7 0.15 12.0 8.7 1.5 1 0 0 1 1 1 0 TMEM154 protein family DUF908 PF06012.12 EFA82167.1 - 0.2 11.1 6.0 0.28 10.5 6.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) PALP PF00291.25 EFA82169.1 - 8e-82 275.0 0.0 4.6e-75 252.7 0.1 4.0 3 1 0 3 3 3 2 Pyridoxal-phosphate dependent enzyme ACT_5 PF13710.6 EFA82169.1 - 0.011 15.6 0.1 0.045 13.6 0.1 2.0 2 0 0 2 2 2 0 ACT domain ACT_4 PF13291.6 EFA82169.1 - 0.04 14.5 0.1 0.04 14.5 0.1 3.2 3 0 0 3 3 3 0 ACT domain DUF4805 PF16063.5 EFA82169.1 - 0.78 9.0 10.5 1.6 8.0 10.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) NST1 PF13945.6 EFA82169.1 - 8.6 6.4 9.2 21 5.1 9.2 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator Ribonuclease_T2 PF00445.18 EFA82171.1 - 6e-51 173.3 1.2 7e-51 173.0 1.2 1.0 1 0 0 1 1 1 1 Ribonuclease T2 family TFIIA PF03153.13 EFA82172.1 - 0.00038 20.6 40.4 0.0005 20.2 40.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 EFA82172.1 - 0.2 9.9 34.6 0.25 9.6 34.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ORC6 PF05460.13 EFA82172.1 - 0.22 10.7 21.7 0.35 10.1 21.7 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Raftlin PF15250.6 EFA82172.1 - 0.34 9.6 15.1 0.5 9.0 15.1 1.3 1 0 0 1 1 1 0 Raftlin Dicty_REP PF05086.12 EFA82172.1 - 0.61 8.0 15.5 1 7.3 15.5 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hid1 PF12722.7 EFA82172.1 - 0.73 7.9 19.8 0.98 7.5 19.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 EFA82172.1 - 1.2 7.7 25.0 2 7.0 25.0 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mitofilin PF09731.9 EFA82172.1 - 1.3 7.8 28.1 1.9 7.2 28.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Asp-B-Hydro_N PF05279.11 EFA82172.1 - 1.5 8.8 13.4 2.3 8.2 13.4 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Plasmodium_Vir PF05795.11 EFA82172.1 - 2.6 7.4 12.6 4.5 6.6 9.6 2.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein GREB1 PF15782.5 EFA82172.1 - 6.9 3.7 25.2 8.8 3.3 25.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 EFA82172.1 - 7.4 5.2 21.6 11 4.6 21.6 1.4 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 EFA82172.1 - 9.6 5.7 28.5 20 4.6 28.5 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CBM49 PF09478.10 EFA82173.1 - 2.9e-18 66.0 1.4 4.7e-18 65.3 0.5 1.8 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 COG4 PF08318.12 EFA82174.1 - 1.1e-46 159.4 18.1 2e-46 158.7 18.1 1.4 1 0 0 1 1 1 1 COG4 transport protein zf-C4H2 PF10146.9 EFA82174.1 - 2.4 8.4 22.2 0.019 15.3 3.3 2.9 3 0 0 3 3 3 0 Zinc finger-containing protein SUIM_assoc PF16619.5 EFA82174.1 - 3.8 7.7 14.2 6.1 7.0 0.9 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RRM_1 PF00076.22 EFA82175.1 - 2.9e-35 119.9 1.2 4.6e-19 68.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA82175.1 - 1.6e-06 27.7 0.0 3.8e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EFA82175.1 - 0.00013 22.3 0.2 1.1 9.5 0.0 3.2 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EFA82175.1 - 0.0028 17.7 0.2 0.41 10.8 0.0 3.1 3 1 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 EFA82175.1 - 0.0057 16.5 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 1 Occluded RNA-recognition motif OB_RNB PF08206.11 EFA82175.1 - 0.022 14.4 0.0 5.1 6.9 0.0 2.6 2 0 0 2 2 2 0 Ribonuclease B OB domain DbpA PF03880.15 EFA82175.1 - 0.066 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 DbpA RNA binding domain Hid1 PF12722.7 EFA82175.1 - 5.5 5.0 6.3 7.1 4.6 6.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LIM PF00412.22 EFA82176.1 - 9.8e-25 86.6 34.9 9.3e-10 38.6 6.5 4.6 4 1 0 4 4 4 3 LIM domain ATP-synt PF00231.19 EFA82176.1 - 1.4 8.6 3.7 0.66 9.7 0.9 1.9 3 0 0 3 3 3 0 ATP synthase Claudin_2 PF13903.6 EFA82177.1 - 0.011 15.6 2.5 0.011 15.6 2.5 2.9 1 1 3 4 4 4 0 PMP-22/EMP/MP20/Claudin tight junction PNTB PF02233.16 EFA82177.1 - 0.11 11.4 2.7 0.36 9.7 0.8 2.1 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit DUF2721 PF11026.8 EFA82177.1 - 0.63 9.9 19.2 0.084 12.8 0.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) DUF996 PF06195.13 EFA82178.1 - 0.0064 16.8 1.5 0.0064 16.8 1.5 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF996) W2 PF02020.18 EFA82178.1 - 0.092 12.9 0.2 0.14 12.3 0.2 1.3 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon FtsH_ext PF06480.15 EFA82178.1 - 2.4 8.6 5.7 1.7 9.0 0.3 2.6 2 1 0 2 2 2 0 FtsH Extracellular HMG_box PF00505.19 EFA82179.1 - 3e-18 66.0 1.9 3e-18 66.0 1.9 2.3 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFA82179.1 - 5.6e-14 52.5 1.1 5.6e-14 52.5 1.1 2.5 2 2 0 2 2 2 1 HMG-box domain YABBY PF04690.13 EFA82179.1 - 7.4 7.1 14.1 0.7 10.4 9.1 1.7 1 1 1 2 2 2 0 YABBY protein UQ_con PF00179.26 EFA82181.1 - 9.9e-35 119.2 0.1 4.6e-27 94.4 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme UEV PF05743.13 EFA82181.1 - 0.00019 21.3 0.6 0.0013 18.6 0.0 2.6 2 1 0 2 2 2 1 UEV domain RWD PF05773.22 EFA82181.1 - 0.011 16.1 0.0 1.1 9.6 0.0 3.1 2 0 0 2 2 2 0 RWD domain COG5 PF10392.9 EFA82182.1 - 2e-29 102.4 5.0 2e-29 102.4 5.0 4.0 3 1 0 4 4 4 1 Golgi transport complex subunit 5 COG2 PF06148.11 EFA82182.1 - 7.5e-10 39.0 5.2 7.5e-10 39.0 5.2 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EFA82182.1 - 1.9e-06 27.9 4.9 8.9e-06 25.7 4.9 2.3 1 0 0 1 1 1 1 Vps51/Vps67 Sec8_exocyst PF04048.14 EFA82182.1 - 0.0034 17.3 5.0 0.0034 17.3 5.0 2.7 3 1 0 3 3 3 1 Sec8 exocyst complex component specific domain Occludin_ELL PF07303.13 EFA82182.1 - 0.2 12.4 6.3 35 5.2 4.3 3.5 2 1 1 3 3 3 0 Occludin homology domain TMF_TATA_bd PF12325.8 EFA82182.1 - 2.9 8.1 8.1 0.3 11.3 1.9 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Pyr_redox_2 PF07992.14 EFA82184.1 - 6.1e-41 140.6 0.1 9.8e-41 139.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA82184.1 - 1.3e-18 67.3 2.2 2.3e-13 50.5 0.4 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA82184.1 - 3e-12 46.4 1.7 1.5e-09 37.5 0.2 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA82184.1 - 1.1e-08 35.0 0.8 4.9e-05 23.1 0.0 3.3 3 1 1 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFA82184.1 - 5.3e-07 29.1 0.2 0.0021 17.3 0.0 2.7 1 1 2 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFA82184.1 - 7.3e-06 26.1 0.2 0.0074 16.5 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFA82184.1 - 1.5e-05 24.3 0.1 0.32 10.0 0.0 3.3 3 1 1 4 4 4 2 Lycopene cyclase protein ApbA PF02558.16 EFA82184.1 - 1.8e-05 24.4 1.0 0.011 15.4 0.1 2.9 2 2 0 2 2 2 2 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EFA82184.1 - 2e-05 24.0 0.0 0.015 14.5 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain NAD_binding_7 PF13241.6 EFA82184.1 - 2.7e-05 24.5 2.9 0.15 12.5 0.0 3.3 3 1 0 3 3 3 2 Putative NAD(P)-binding HI0933_like PF03486.14 EFA82184.1 - 7e-05 21.7 0.4 0.48 9.1 0.0 3.2 3 0 0 3 3 3 2 HI0933-like protein TrkA_N PF02254.18 EFA82184.1 - 0.00053 20.2 1.9 0.26 11.6 0.1 2.9 2 0 0 2 2 2 2 TrkA-N domain Trp_halogenase PF04820.14 EFA82184.1 - 0.00084 18.3 0.8 0.032 13.1 0.0 2.2 2 0 0 2 2 2 1 Tryptophan halogenase AlaDh_PNT_C PF01262.21 EFA82184.1 - 0.0013 18.1 0.3 0.18 11.0 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 EFA82184.1 - 0.0027 17.8 0.5 0.75 9.9 0.1 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EFA82184.1 - 0.0058 16.5 0.9 1 9.2 0.2 2.6 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 EFA82184.1 - 0.013 14.8 0.4 0.31 10.2 0.1 2.3 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EFA82184.1 - 0.014 14.6 0.7 0.87 8.6 0.0 2.7 3 0 0 3 3 3 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 EFA82184.1 - 0.014 15.6 1.7 3.6 7.8 0.1 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF1188 PF06690.11 EFA82184.1 - 0.023 14.3 0.9 0.18 11.3 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1188) NAD_binding_9 PF13454.6 EFA82184.1 - 0.024 14.6 3.7 3.4 7.7 0.0 3.4 3 1 1 4 4 4 0 FAD-NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 EFA82184.1 - 0.049 13.6 0.1 3.3 7.7 0.0 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 EFA82184.1 - 0.099 12.2 3.5 2.7 7.5 0.3 2.5 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.21 EFA82184.1 - 0.13 11.5 1.0 1.2 8.4 0.0 2.4 2 0 0 2 2 2 0 ThiF family DUF3710 PF12502.8 EFA82184.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3710) CBM49 PF09478.10 EFA82185.1 - 2.9e-18 66.0 1.4 4.7e-18 65.3 0.5 1.8 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 Xpo1 PF08389.12 EFA82186.1 - 0.054 13.5 3.9 3.4 7.7 0.4 2.7 2 1 0 2 2 2 0 Exportin 1-like protein DUF1786 PF08735.10 EFA82187.1 - 0.11 11.7 0.1 0.14 11.4 0.1 1.1 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) DUF3430 PF11912.8 EFA82188.1 - 3e-17 63.4 26.7 3.6e-17 63.1 26.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) nec1 PF10379.9 EFA82188.1 - 0.09 12.3 3.4 0.096 12.2 0.9 1.8 1 1 1 2 2 2 0 Virulence protein nec1 Vps52 PF04129.12 EFA82190.1 - 1.1e-36 126.7 32.6 5.7e-18 64.9 13.6 4.3 2 1 2 4 4 4 3 Vps52 / Sac2 family Sec3_C PF09763.9 EFA82190.1 - 3.7e-06 25.7 16.2 2.6e-05 22.9 9.7 3.8 3 1 1 4 4 3 2 Exocyst complex component Sec3 Atg14 PF10186.9 EFA82190.1 - 0.015 14.4 9.3 0.031 13.4 9.3 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 EFA82190.1 - 0.21 10.9 6.1 0.53 9.6 6.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C4H2 PF10146.9 EFA82190.1 - 0.46 10.7 11.2 4.1 7.6 6.9 2.5 2 0 0 2 2 2 0 Zinc finger-containing protein OmpH PF03938.14 EFA82190.1 - 0.57 10.5 20.8 0.029 14.7 12.8 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 EFA82190.1 - 0.95 9.0 13.9 0.61 9.6 8.7 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit FUSC PF04632.12 EFA82190.1 - 1.6 7.1 2.9 2.5 6.6 2.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GLTP PF08718.11 EFA82190.1 - 2.3 8.5 7.0 13 6.1 7.0 2.4 1 1 0 1 1 1 0 Glycolipid transfer protein (GLTP) COG2 PF06148.11 EFA82190.1 - 3.6 7.7 24.0 0.59 10.2 5.9 3.7 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 EFA82190.1 - 4.3 6.1 27.3 0.36 9.6 17.0 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.8 EFA82190.1 - 5.1 6.3 20.0 0.2 10.9 14.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DegT_DnrJ_EryC1 PF01041.17 EFA82190.1 - 5.2 6.3 6.2 14 4.9 5.8 1.8 1 1 1 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family zf-ZPR1 PF03367.13 EFA82190.1 - 8.1 6.3 10.9 18 5.1 0.1 3.3 3 1 1 4 4 4 0 ZPR1 zinc-finger domain DUF2046 PF09755.9 EFA82191.1 - 5.7e-25 88.2 58.6 3e-22 79.2 30.4 2.3 1 1 1 2 2 2 2 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 EFA82191.1 - 0.0021 18.3 12.3 0.0021 18.3 12.3 2.3 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) MetW PF07021.12 EFA82191.1 - 0.1 12.2 3.8 0.35 10.5 2.3 2.1 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW tRNA-synt_2c PF01411.19 EFA82192.1 - 7.1e-117 391.2 0.0 3.4e-94 316.4 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFA82192.1 - 6.3e-17 61.4 0.3 1.4e-16 60.3 0.3 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EFA82192.1 - 1.3e-05 25.7 1.1 1.3e-05 25.7 1.1 2.1 2 0 0 2 2 2 1 DHHA1 domain Tropomyosin_1 PF12718.7 EFA82192.1 - 0.19 11.9 3.9 1.2 9.3 0.5 2.3 2 0 0 2 2 2 0 Tropomyosin like Nucleoporin_FG PF13634.6 EFA82193.1 - 4.1e-07 30.8 76.8 4.9e-05 24.1 38.8 6.7 2 2 3 5 5 5 2 Nucleoporin FG repeat region RPW8 PF05659.11 EFA82193.1 - 0.022 14.4 0.7 1.1 9.0 0.1 2.5 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 IFT57 PF10498.9 EFA82193.1 - 0.18 10.7 4.4 0.75 8.7 0.4 2.3 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 ABC_membrane PF00664.23 EFA82194.1 - 1.6e-54 185.5 37.9 7e-32 111.2 12.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA82194.1 - 2.4e-50 170.6 0.0 2.7e-27 95.9 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA82194.1 - 3.3e-10 39.8 7.2 5.5e-05 22.7 0.1 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFA82194.1 - 4.7e-05 23.4 1.0 0.0045 16.9 0.1 2.6 3 0 0 3 3 2 1 RsgA GTPase AAA_23 PF13476.6 EFA82194.1 - 0.00014 22.4 6.6 0.0084 16.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EFA82194.1 - 0.00019 21.5 5.5 0.057 13.5 0.2 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA82194.1 - 0.00063 19.4 1.0 1.5 8.7 0.1 3.2 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EFA82194.1 - 0.0012 18.7 10.2 0.06 13.1 0.0 4.6 5 0 0 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFA82194.1 - 0.0021 18.4 0.0 0.1 13.0 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EFA82194.1 - 0.0023 17.5 0.2 1.9 8.0 0.1 2.3 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 EFA82194.1 - 0.0055 16.4 0.0 2.6 7.6 0.0 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 EFA82194.1 - 0.041 13.4 1.0 2.5 7.6 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 EFA82194.1 - 0.042 14.1 2.5 2.6 8.3 0.3 2.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFA82194.1 - 0.052 14.0 1.8 0.42 11.0 0.0 3.0 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EFA82194.1 - 0.069 12.3 2.1 3.3 6.8 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.12 EFA82194.1 - 0.24 10.7 0.9 4.2 6.6 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EFA82194.1 - 1.1 9.1 4.4 62 3.4 0.0 3.4 3 0 0 3 3 3 0 NTPase cobW PF02492.19 EFA82194.1 - 1.9 8.0 4.3 1.6 8.3 0.4 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EFA82194.1 - 8.1 6.5 6.5 1.7 8.7 1.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_15 PF13175.6 EFA82194.1 - 9.4 5.8 12.3 0.82 9.3 0.3 3.3 3 0 0 3 3 3 0 AAA ATPase domain ILEI PF15711.5 EFA82196.1 - 8.4e-65 215.3 22.3 3.5e-14 53.0 0.9 6.8 6 0 0 6 6 6 6 Interleukin-like EMT inducer Laminin_G_3 PF13385.6 EFA82196.1 - 2.2e-12 47.4 3.0 2.2e-12 47.4 3.0 3.6 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EFA82196.1 - 0.0063 17.1 0.0 0.02 15.5 0.0 1.9 1 0 0 1 1 1 1 Laminin G domain Lactonase PF10282.9 EFA82196.1 - 2.1 7.5 5.8 2.2 7.4 0.4 3.4 5 0 0 5 5 5 0 Lactonase, 7-bladed beta-propeller ILEI PF15711.5 EFA82197.1 - 5.1e-59 196.7 14.0 3.8e-17 62.5 0.1 5.7 5 0 0 5 5 5 5 Interleukin-like EMT inducer rve PF00665.26 EFA82198.1 - 9.1e-19 67.8 0.0 1.6e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EFA82198.1 - 8.4e-11 41.6 1.4 1.9e-10 40.5 1.4 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 EFA82198.1 - 0.021 14.6 0.1 0.048 13.4 0.1 1.7 1 0 0 1 1 1 0 Integrase core domain DUF5341 PF17276.2 EFA82198.1 - 0.61 10.2 5.5 0.19 11.9 1.4 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5341) TPR_20 PF14561.6 EFA82199.1 - 1.6e-25 89.2 0.4 1.9e-24 85.8 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Thioredoxin PF00085.20 EFA82199.1 - 1.3e-13 50.8 0.1 3.9e-13 49.3 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin ANAPC3 PF12895.7 EFA82199.1 - 2.2e-06 27.8 0.2 0.038 14.2 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Thioredoxin_6 PF13848.6 EFA82199.1 - 0.0003 20.8 0.0 0.0007 19.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain TPR_19 PF14559.6 EFA82199.1 - 0.00054 20.4 1.7 0.33 11.5 0.6 3.1 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA82199.1 - 0.0032 18.0 0.3 0.66 10.7 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA82199.1 - 0.0057 16.7 0.3 0.48 10.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA82199.1 - 0.0067 16.1 0.4 0.49 10.1 0.1 2.5 2 0 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 EFA82199.1 - 0.012 15.8 2.2 0.4 11.0 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat OST3_OST6 PF04756.13 EFA82199.1 - 0.018 14.4 0.0 0.043 13.2 0.0 1.6 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family Alkyl_sulf_dimr PF14863.6 EFA82199.1 - 0.054 14.0 0.1 7.4 7.0 0.1 2.7 1 1 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_16 PF13432.6 EFA82199.1 - 0.072 13.7 0.0 1.6 9.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA82199.1 - 0.1 13.5 0.0 14 6.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat SR-25 PF10500.9 EFA82199.1 - 0.79 9.3 5.7 1.3 8.6 5.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TMF_TATA_bd PF12325.8 EFA82199.1 - 9.3 6.5 8.8 4.4 7.6 3.3 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding VSP PF03302.13 EFA82200.1 - 0.36 9.6 2.5 0.21 10.4 0.5 1.5 2 0 0 2 2 2 0 Giardia variant-specific surface protein Coilin_N PF15862.5 EFA82201.1 - 4.2e-22 78.5 5.6 4.2e-22 78.5 5.6 5.9 3 1 3 6 6 6 2 Coilin N-terminus CBS PF00571.28 EFA82202.1 - 2.5e-26 91.9 2.6 1.1e-08 35.4 0.0 4.2 4 0 0 4 4 4 4 CBS domain EamA PF00892.20 EFA82203.1 - 3.1e-30 105.1 35.7 1.2e-16 61.2 14.6 2.2 2 0 0 2 2 2 2 EamA-like transporter family JAKMIP_CC3 PF16034.5 EFA82203.1 - 0.19 11.7 0.1 0.31 11.0 0.1 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain TMEM234 PF10639.9 EFA82203.1 - 1.3 9.1 8.1 2.1 8.4 1.0 3.3 3 0 0 3 3 3 0 Putative transmembrane family 234 DDHD PF02862.17 EFA82204.1 - 1.5e-32 113.5 0.1 1.5e-32 113.5 0.1 2.4 2 1 0 2 2 2 1 DDHD domain DUF676 PF05057.14 EFA82204.1 - 0.038 13.5 0.1 0.17 11.3 0.0 2.0 2 0 0 2 2 2 0 Putative serine esterase (DUF676) SpoVR PF04293.13 EFA82204.1 - 0.048 12.4 0.3 0.082 11.6 0.3 1.3 1 0 0 1 1 1 0 SpoVR like protein LIDHydrolase PF10230.9 EFA82204.1 - 0.066 12.8 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EFA82204.1 - 0.09 12.0 0.0 1.4 8.2 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 CUE PF02845.16 EFA82206.1 - 1.2e-07 31.2 0.1 1.2e-07 31.2 0.1 2.1 2 0 0 2 2 1 1 CUE domain zf-RING_2 PF13639.6 EFA82206.1 - 2.7e-07 30.8 4.6 2.7e-07 30.8 4.6 1.8 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA82206.1 - 2.3e-05 24.3 0.6 5.9e-05 23.0 0.6 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EFA82206.1 - 2.7e-05 23.8 0.6 7.6e-05 22.4 0.6 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFA82206.1 - 7.8e-05 22.4 5.4 0.00016 21.5 5.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA82206.1 - 0.00018 21.3 1.9 0.00037 20.3 1.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA82206.1 - 0.0019 18.1 3.2 0.0019 18.1 3.2 2.0 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFA82206.1 - 0.002 18.0 2.8 0.0048 16.7 2.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFA82206.1 - 0.0066 16.7 11.2 0.016 15.5 7.9 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFA82206.1 - 0.0067 16.3 5.1 0.019 14.8 5.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) G2BR PF18442.1 EFA82206.1 - 0.1 12.2 2.5 0.19 11.4 2.5 1.4 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) Macoilin PF09726.9 EFA82206.1 - 2.1 6.8 26.1 3.4 6.1 26.1 1.2 1 0 0 1 1 1 0 Macoilin family zf-C3H2C3 PF17122.5 EFA82206.1 - 2.3 8.3 7.3 0.26 11.4 2.4 2.0 2 0 0 2 2 2 0 Zinc-finger PNISR PF15996.5 EFA82206.1 - 7.8 6.7 14.2 15 5.8 14.2 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Pkinase PF00069.25 EFA82207.1 - 6.7e-75 251.8 0.0 8.6e-75 251.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82207.1 - 8e-45 153.1 0.0 1.1e-44 152.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA82207.1 - 1.4e-08 34.4 0.0 1.2e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.9 EFA82207.1 - 0.061 12.8 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EFA82207.1 - 0.075 12.0 0.0 0.14 11.0 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EFA82207.1 - 0.099 12.3 0.1 1.8 8.2 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 EFA82207.1 - 0.22 10.6 0.0 0.45 9.5 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Ras PF00071.22 EFA82208.1 - 1.1e-46 158.4 0.0 1.3e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82208.1 - 6.4e-30 103.8 0.0 9.8e-30 103.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82208.1 - 2e-16 59.9 0.0 2.6e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA82208.1 - 2.2e-07 30.5 0.0 2.8e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFA82208.1 - 1.8e-05 24.3 0.0 0.00019 21.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFA82208.1 - 0.0082 15.9 0.1 0.95 9.2 0.0 2.3 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFA82208.1 - 0.025 14.0 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DLIC PF05783.11 EFA82208.1 - 0.026 13.4 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) RsgA_GTPase PF03193.16 EFA82208.1 - 0.035 14.0 0.1 0.094 12.6 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase GSH-S_ATP PF02955.16 EFA82209.1 - 1.3e-08 34.5 0.0 2.6e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 EFA82209.1 - 0.035 14.1 0.1 0.08 13.0 0.1 1.6 1 0 0 1 1 1 0 ATP-grasp domain Glutaredoxin PF00462.24 EFA82210.1 - 2.4e-18 66.1 0.1 1.2e-17 63.9 0.0 2.2 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin PF00085.20 EFA82210.1 - 7.9e-16 57.9 0.1 1.6e-15 56.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFA82210.1 - 6.7e-05 23.1 0.2 0.0023 18.2 0.0 2.7 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFA82210.1 - 0.0015 18.9 0.3 0.027 14.9 0.1 2.7 2 2 1 3 3 3 1 Thioredoxin-like domain DIM1 PF02966.16 EFA82210.1 - 0.015 15.1 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 Phosducin PF02114.16 EFA82210.1 - 0.069 12.1 0.1 0.18 10.7 0.0 1.6 2 0 0 2 2 2 0 Phosducin RINGv PF12906.7 EFA82211.1 - 0.044 13.9 0.6 0.44 10.7 0.1 2.1 2 0 0 2 2 2 0 RING-variant domain Cbl_N2 PF02761.14 EFA82212.1 - 4.3e-23 81.8 4.1 1.5e-22 80.1 4.1 1.9 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain zf-C3HC4_3 PF13920.6 EFA82212.1 - 5.3e-14 51.8 11.0 9.2e-14 51.0 11.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SH2 PF00017.24 EFA82212.1 - 6.1e-09 35.8 0.1 3.9e-08 33.3 0.0 2.5 2 0 0 2 2 2 1 SH2 domain Prok-RING_4 PF14447.6 EFA82212.1 - 0.00014 21.6 12.3 0.00029 20.6 12.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Cbl_N3 PF02762.14 EFA82212.1 - 0.0023 17.8 0.1 0.034 14.0 0.0 2.6 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, SH2-like domain zf-RING_5 PF14634.6 EFA82212.1 - 0.086 12.8 12.4 0.16 12.0 12.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EFA82212.1 - 0.28 11.5 12.5 0.71 10.2 12.5 1.7 1 0 0 1 1 1 0 Ring finger domain DUF3439 PF11921.8 EFA82212.1 - 0.75 9.8 5.3 2.5 8.1 5.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AAA_11 PF13086.6 EFA82214.1 - 1.4e-72 244.7 5.5 5.3e-35 121.5 0.0 3.2 2 1 1 3 3 3 2 AAA domain AAA_12 PF13087.6 EFA82214.1 - 4.2e-59 199.5 0.0 2.2e-58 197.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA82214.1 - 3.5e-10 39.9 0.0 0.00041 20.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFA82214.1 - 6.8e-09 36.2 0.4 0.0024 18.2 0.2 2.9 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EFA82214.1 - 1.5e-08 34.7 0.0 0.0073 16.1 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 EFA82214.1 - 0.0013 18.4 3.2 0.46 10.0 0.0 3.5 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EFA82214.1 - 0.0058 16.9 0.1 0.063 13.6 0.0 2.8 4 0 0 4 4 4 1 AAA domain PhoH PF02562.16 EFA82214.1 - 0.011 15.1 0.0 0.27 10.6 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 EFA82214.1 - 0.021 15.2 0.1 0.068 13.5 0.1 1.9 1 0 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.9 EFA82214.1 - 0.028 13.7 6.3 0.57 9.4 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EFA82214.1 - 0.03 13.7 0.0 0.058 12.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EFA82214.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DHO_dh PF01180.21 EFA82215.1 - 1.4e-33 116.4 0.0 5.2e-33 114.5 0.0 2.0 3 0 0 3 3 3 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.6 EFA82215.1 - 3.2e-33 113.8 0.4 3.2e-33 113.8 0.4 2.7 2 2 1 3 3 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.6 EFA82215.1 - 2.1e-23 82.2 12.9 2.1e-23 82.2 12.9 3.9 4 1 0 4 4 4 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.14 EFA82215.1 - 5.1e-12 45.6 0.0 8.6e-10 38.3 0.0 1.8 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Dus PF01207.17 EFA82215.1 - 6.4e-07 28.8 0.0 2.2e-06 27.0 0.1 1.8 3 0 0 3 3 3 1 Dihydrouridine synthase (Dus) NAD_binding_8 PF13450.6 EFA82215.1 - 5.7e-06 26.5 0.0 1.7e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFA82215.1 - 1.7e-05 25.3 0.1 0.39 11.3 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_2 PF12797.7 EFA82215.1 - 4.6e-05 23.3 34.0 0.0058 16.7 2.9 5.2 5 0 0 5 5 5 3 4Fe-4S binding domain Fer4_6 PF12837.7 EFA82215.1 - 5.1e-05 23.2 33.4 7.7e-05 22.6 1.8 4.9 5 0 0 5 5 4 3 4Fe-4S binding domain Pyr_redox_3 PF13738.6 EFA82215.1 - 9.7e-05 21.8 0.0 0.23 10.7 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 EFA82215.1 - 0.00019 21.9 11.1 0.00019 21.9 11.1 3.7 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4 PF00037.27 EFA82215.1 - 0.0005 19.8 14.1 0.0019 17.9 2.3 4.9 5 0 0 5 5 5 2 4Fe-4S binding domain Fer4_10 PF13237.6 EFA82215.1 - 0.0013 18.8 10.9 0.0013 18.8 10.9 3.9 3 2 1 4 4 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFA82215.1 - 0.0017 18.5 10.9 0.0017 18.5 10.9 3.4 4 0 0 4 4 2 2 4Fe-4S dicluster domain NAD_binding_9 PF13454.6 EFA82215.1 - 0.034 14.2 0.0 0.62 10.0 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 EFA82215.1 - 0.035 13.7 0.1 0.08 12.5 0.1 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Fer4_17 PF13534.6 EFA82215.1 - 0.037 14.6 21.8 0.1 13.2 0.8 4.3 4 0 0 4 4 3 0 4Fe-4S dicluster domain GIDA PF01134.22 EFA82215.1 - 0.11 11.6 0.2 0.64 9.0 0.0 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A Fer4_15 PF13459.6 EFA82215.1 - 1.8 9.4 11.3 4.3 8.1 0.8 3.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_22 PF17179.4 EFA82215.1 - 1.9 9.4 14.5 4 8.3 0.2 4.2 4 0 0 4 4 3 0 4Fe-4S dicluster domain cNMPbd_u2 PF16643.5 EFA82216.1 - 0.12 12.9 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 Unstructured region on cNMP-binding protein CH PF00307.31 EFA82217.1 - 3.1e-40 136.8 18.6 6.8e-23 80.9 0.1 5.1 4 0 0 4 4 4 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA82217.1 - 4.4e-09 36.0 1.7 5.3e-06 26.2 0.0 3.6 3 0 0 3 3 3 2 CAMSAP CH domain DUF745 PF05335.13 EFA82217.1 - 0.005 16.6 1.6 0.005 16.6 1.6 10.3 2 1 9 12 12 12 1 Protein of unknown function (DUF745) DUF4083 PF13314.6 EFA82217.1 - 0.09 12.7 0.9 1.4 8.9 0.9 3.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) CH_2 PF06294.11 EFA82217.1 - 0.35 11.0 12.2 2 8.6 0.0 5.0 5 0 0 5 5 5 0 CH-like domain in sperm protein UQ_con PF00179.26 EFA82218.1 - 9.5e-46 154.9 0.0 1.1e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFA82218.1 - 0.0011 18.7 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B ERG4_ERG24 PF01222.17 EFA82219.1 - 1.1e-128 429.7 16.7 1.3e-128 429.5 16.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Cpn60_TCP1 PF00118.24 EFA82220.1 - 8.3e-105 351.2 6.7 4.8e-103 345.4 6.7 2.1 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mito_carr PF00153.27 EFA82220.1 - 7.3e-50 166.9 4.8 1.6e-19 69.6 0.2 3.6 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_S28e PF01200.18 EFA82220.1 - 3.3e-21 75.0 0.1 7.5e-21 73.9 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S28e UPF0154 PF03672.13 EFA82220.1 - 0.058 13.4 0.2 0.17 12.0 0.2 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Sporozoite_P67 PF05642.11 EFA82221.1 - 0.036 12.2 9.8 0.042 11.9 9.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PAP1 PF08601.10 EFA82221.1 - 1.3 8.6 10.8 1.8 8.2 10.8 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Pex14_N PF04695.13 EFA82221.1 - 3 8.5 6.9 5 7.8 6.9 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MGC-24 PF05283.11 EFA82221.1 - 5.7 7.4 15.3 17 5.8 15.3 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 EFA82221.1 - 7.6 4.5 17.5 10 4.1 17.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF515 PF04415.12 EFA82221.1 - 8.9 4.6 14.2 11 4.3 14.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) TBCC PF07986.12 EFA82222.1 - 1.3e-23 83.0 6.2 2.8e-21 75.5 6.2 2.6 1 1 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EFA82222.1 - 1.3e-05 25.6 8.7 1.3e-05 25.6 8.7 2.0 2 0 0 2 2 2 1 Tubulin-specific chaperone C N-terminal domain TMPIT PF07851.13 EFA82222.1 - 0.64 9.2 7.9 0.84 8.8 7.3 1.5 1 1 0 1 1 1 0 TMPIT-like protein Polo_box_3 PF18544.1 EFA82222.1 - 3.3 8.4 5.6 1.5 9.5 1.8 2.4 2 2 1 3 3 3 0 Polo box domain DUF948 PF06103.11 EFA82222.1 - 4 7.8 6.7 1 9.7 0.4 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF659 PF04937.15 EFA82223.1 - 1.2e-07 31.7 0.9 2.3e-07 30.8 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) PAXX PF15384.6 EFA82223.1 - 0.0023 17.7 0.0 0.0056 16.4 0.0 1.7 1 0 0 1 1 1 1 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Dimer_Tnp_hAT PF05699.14 EFA82224.1 - 1.8e-16 59.7 0.4 3.8e-16 58.7 0.4 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-B_box PF00643.24 EFA82225.1 - 7.8e-05 22.7 7.5 0.00024 21.2 7.5 1.9 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA82225.1 - 0.0059 16.9 4.9 0.094 13.0 0.2 3.7 3 1 0 3 3 3 1 Kelch motif ParBc_2 PF08857.11 EFA82225.1 - 0.029 14.5 1.5 0.032 14.3 0.3 1.9 1 1 1 2 2 2 0 Putative ParB-like nuclease YcgR PF07317.12 EFA82225.1 - 0.29 11.0 4.6 0.3 11.0 0.1 3.0 3 1 0 4 4 4 0 Flagellar regulator YcgR TPR_19 PF14559.6 EFA82226.1 - 0.12 12.9 3.6 1.2 9.7 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 EFA82228.1 - 2.4e-57 194.2 0.1 3.1e-57 193.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA82228.1 - 1.3e-48 165.7 0.0 1.9e-48 165.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 EFA82228.1 - 2.3e-11 43.9 0.2 7.8e-11 42.3 0.2 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA82228.1 - 3.5e-08 33.4 0.1 1.6e-07 31.3 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Haspin_kinase PF12330.8 EFA82228.1 - 2e-05 23.7 0.0 0.012 14.5 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain Ank_3 PF13606.6 EFA82228.1 - 3.7e-05 23.8 0.0 0.00079 19.7 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EFA82228.1 - 9.9e-05 22.9 0.0 0.00034 21.2 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82228.1 - 0.00012 22.6 0.2 0.027 15.0 0.0 3.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA82228.1 - 0.0036 17.7 0.1 0.013 15.9 0.0 2.0 2 0 0 2 2 1 1 Ankyrin repeat FTA2 PF13095.6 EFA82228.1 - 0.0078 15.9 0.2 0.12 12.0 0.2 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Ank_5 PF13857.6 EFA82228.1 - 0.011 16.0 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) RIO1 PF01163.22 EFA82228.1 - 0.013 15.1 0.2 0.044 13.4 0.2 1.7 1 1 1 2 2 2 0 RIO1 family APH PF01636.23 EFA82228.1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Hpr_kinase_N PF02603.16 EFA82228.1 - 0.02 14.9 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase N terminus Xol-1_N PF09108.10 EFA82228.1 - 0.38 10.6 1.6 0.84 9.5 0.5 1.9 1 1 0 2 2 2 0 Switch protein XOL-1, N-terminal Methyltransf_4 PF02390.17 EFA82229.1 - 7.8e-26 90.6 0.0 7.8e-26 90.6 0.0 2.9 2 1 0 2 2 2 1 Putative methyltransferase PPR_2 PF13041.6 EFA82229.1 - 1.7e-14 53.7 7.6 4.2e-07 30.0 0.5 3.9 2 2 2 4 4 4 4 PPR repeat family PPR PF01535.20 EFA82229.1 - 4e-08 33.0 5.5 0.018 15.3 0.1 4.2 3 1 0 3 3 3 2 PPR repeat PPR_long PF17177.4 EFA82229.1 - 3.1e-06 26.7 0.6 7.7e-06 25.4 0.6 1.6 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EFA82229.1 - 4e-05 23.6 8.0 0.00079 19.5 0.1 3.2 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFA82229.1 - 0.00053 19.6 2.3 4.4 7.1 0.1 3.4 3 0 0 3 3 3 3 PPR repeat COX5A PF02284.16 EFA82229.1 - 0.0036 17.3 2.8 1.2 9.2 0.1 3.1 2 1 1 3 3 3 2 Cytochrome c oxidase subunit Va Hamartin PF04388.12 EFA82229.1 - 3.8 6.1 31.7 0.14 10.8 23.0 2.1 2 0 0 2 2 2 0 Hamartin protein LSM PF01423.22 EFA82230.1 - 1.3e-18 66.5 0.0 1.4e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA82230.1 - 0.036 14.2 0.0 0.044 13.9 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM14 PF12701.7 EFA82230.1 - 0.14 12.3 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 Scd6-like Sm domain mRNA_decap_C PF16741.5 EFA82230.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus Pex2_Pex12 PF04757.14 EFA82231.1 - 8.6e-51 172.7 8.5 1.3e-50 172.1 8.5 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 EFA82231.1 - 5.1e-05 23.0 4.4 7.9e-05 22.4 4.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA82231.1 - 0.00048 19.9 6.6 0.0008 19.2 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA82231.1 - 0.004 17.5 6.4 0.0067 16.7 6.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA82231.1 - 0.0073 16.2 6.4 0.014 15.2 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA82231.1 - 0.16 12.0 9.7 0.32 11.1 9.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFA82231.1 - 0.26 11.5 8.2 0.46 10.7 8.2 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Nfu_N PF08712.11 EFA82232.1 - 1.5e-29 101.8 0.0 3.6e-29 100.7 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EFA82232.1 - 4.6e-24 84.4 0.0 6.8e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain DEP PF00610.21 EFA82233.1 - 8.4e-06 25.8 0.0 2.7e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) NUDE_C PF04880.13 EFA82233.1 - 2.1 8.8 22.3 0.29 11.6 12.7 2.8 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region NMD3 PF04981.13 EFA82234.1 - 6.3e-80 268.1 6.6 1e-79 267.5 6.6 1.3 1 0 0 1 1 1 1 NMD3 family GP63 PF17471.2 EFA82234.1 - 0.11 12.7 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 Gene product 63 DUF1289 PF06945.13 EFA82234.1 - 0.28 11.0 2.5 7.9 6.4 1.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) KIND PF16474.5 EFA82234.1 - 0.33 10.8 13.6 2.1 8.2 11.4 2.3 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain Pkinase PF00069.25 EFA82235.1 - 2.7e-53 181.0 0.0 4.5e-53 180.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82235.1 - 4.3e-50 170.4 0.0 7e-50 169.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA82235.1 - 0.00032 19.6 2.9 0.00037 19.4 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFA82235.1 - 0.0097 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3860 PF12976.7 EFA82235.1 - 0.014 15.4 0.0 0.037 14.0 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) Menin PF05053.13 EFA82235.1 - 0.53 8.6 6.6 0.77 8.1 6.6 1.2 1 0 0 1 1 1 0 Menin Zip PF02535.22 EFA82235.1 - 9.3 5.4 6.8 14 4.8 6.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SapB_1 PF05184.15 EFA82236.1 - 8.3e-06 25.7 4.6 8.3e-06 25.7 4.6 2.2 2 0 0 2 2 2 1 Saposin-like type B, region 1 Argos PF11581.8 EFA82236.1 - 0.057 13.5 2.1 0.14 12.2 2.1 1.7 1 1 0 1 1 1 0 Antagonist of EGFR signalling, Argos Arrestin_N PF00339.29 EFA82237.1 - 0.003 17.6 0.0 0.003 17.6 0.0 2.7 4 0 0 4 4 4 1 Arrestin (or S-antigen), N-terminal domain Suf PF05843.14 EFA82237.1 - 1.2 9.0 20.4 0.75 9.7 6.6 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SRF-TF PF00319.18 EFA82238.1 - 4e-12 45.4 0.6 7.6e-12 44.5 0.6 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Myb_DNA-binding PF00249.31 EFA82239.1 - 2.4e-19 69.3 1.6 6.9e-15 55.0 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA82239.1 - 9.8e-18 64.2 4.0 1.1e-11 44.9 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFA82239.1 - 0.0008 19.3 0.1 0.0041 17.0 0.0 2.0 2 0 0 2 2 2 1 Myb DNA-binding like SLIDE PF09111.10 EFA82239.1 - 0.095 12.7 0.3 0.45 10.5 0.0 2.0 1 1 1 2 2 2 0 SLIDE SANT_DAMP1_like PF16282.5 EFA82239.1 - 0.37 11.0 3.2 0.64 10.2 0.2 2.3 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 Mif2_N PF15624.6 EFA82239.1 - 2.5 8.8 9.8 4.1 8.1 9.8 1.2 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal TPR_12 PF13424.6 EFA82240.1 - 1.7e-05 25.0 3.4 0.091 13.1 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA82240.1 - 0.00045 19.9 1.2 0.0062 16.3 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA82240.1 - 0.014 15.4 0.9 0.11 12.6 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat T3SSipB PF16535.5 EFA82240.1 - 1.2 9.6 6.8 0.53 10.8 0.5 3.0 3 0 0 3 3 3 0 Type III cell invasion protein SipB TPR_1 PF00515.28 EFA82241.1 - 1.4e-06 27.9 0.0 5.5e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA82241.1 - 2.2e-06 27.3 0.0 3.1e-05 23.8 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA82241.1 - 4.4e-05 23.9 4.7 0.0031 18.0 0.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA82241.1 - 5.3e-05 23.1 0.0 0.032 14.4 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFA82241.1 - 0.0014 18.7 0.1 0.023 14.9 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA82241.1 - 0.0046 16.6 0.1 0.021 14.5 0.0 2.1 2 0 0 2 2 2 1 TPR repeat TPR_7 PF13176.6 EFA82241.1 - 0.029 14.4 0.1 3.6 7.8 0.0 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA82241.1 - 0.032 15.0 0.0 0.81 10.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFA82241.1 - 0.086 13.5 0.0 0.42 11.3 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA82241.1 - 0.13 13.0 0.0 11 6.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TFIIA PF03153.13 EFA82241.1 - 3.8 7.4 41.8 1 9.3 3.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RED_N PF07808.13 EFA82241.1 - 6.2 6.3 7.7 2.2 7.8 2.6 2.3 2 0 0 2 2 2 0 RED-like protein N-terminal region Spt20 PF12090.8 EFA82241.1 - 6.3 6.3 39.7 0.82 9.2 9.4 3.5 3 0 0 3 3 3 0 Spt20 family zf-RING_5 PF14634.6 EFA82242.1 - 4.2e-05 23.4 2.8 0.00014 21.7 2.8 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA82242.1 - 0.00014 22.1 4.9 0.00014 22.1 4.9 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA82242.1 - 0.0015 18.5 2.8 0.0059 16.6 2.8 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA82242.1 - 0.0023 17.7 3.8 0.006 16.4 3.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA82242.1 - 0.024 14.5 2.7 0.045 13.6 2.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Secretin_N_2 PF07655.13 EFA82243.1 - 1.4 9.5 14.7 3.3 8.3 14.7 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Pkinase PF00069.25 EFA82244.1 - 1.6e-62 211.3 0.0 4.4e-61 206.6 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82244.1 - 2.9e-45 154.6 0.0 1.5e-44 152.2 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA82244.1 - 0.00026 20.4 0.0 0.00026 20.4 0.0 2.2 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 EFA82244.1 - 0.00045 20.2 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA82244.1 - 0.0049 15.7 0.0 0.0049 15.7 0.0 3.1 3 0 0 3 3 3 1 Fungal protein kinase FTA2 PF13095.6 EFA82244.1 - 0.66 9.6 5.4 1.4 8.5 0.0 2.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF5345 PF17280.2 EFA82244.1 - 9.1 6.3 8.2 24 5.0 8.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5345) PHD PF00628.29 EFA82246.1 - 2.8e-11 43.1 27.9 2.1e-05 24.3 6.7 3.7 3 0 0 3 3 3 3 PHD-finger Glyco_transf_49 PF13896.6 EFA82247.1 - 4.9e-49 167.5 1.7 1.4e-40 139.7 0.7 2.1 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 EFA82247.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 EFA82247.1 - 0.04 14.4 0.2 0.1 13.2 0.2 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 SASRP1 PF15160.6 EFA82248.1 - 0.023 14.4 0.9 0.032 13.9 0.9 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 Pkinase PF00069.25 EFA82250.1 - 6.8e-67 225.6 0.1 1.5e-59 201.5 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82250.1 - 5.2e-33 114.4 0.0 8.6e-33 113.7 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFA82250.1 - 2.1e-06 27.2 0.1 3.1e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFA82250.1 - 0.0061 15.9 0.0 0.56 9.5 0.0 2.2 1 1 0 2 2 2 2 Kinase-like RIO1 PF01163.22 EFA82250.1 - 0.017 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFA82250.1 - 0.22 11.4 0.0 0.51 10.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family SNF2_N PF00176.23 EFA82251.1 - 7.3e-67 225.6 1.7 7.3e-67 225.6 1.7 2.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 EFA82251.1 - 1.3e-45 155.0 13.5 1.3e-45 155.0 13.5 7.1 6 1 1 7 7 7 1 DNA-binding domain Helicase_C PF00271.31 EFA82251.1 - 5.5e-19 68.5 0.0 4e-18 65.8 0.0 2.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Mur_ligase_M PF08245.12 EFA82253.1 - 1.1e-06 28.8 2.7 4e-05 23.7 0.0 3.4 2 1 1 3 3 3 2 Mur ligase middle domain BRAP2 PF07576.12 EFA82254.1 - 1.1e-33 115.4 0.2 3.1e-33 114.0 0.2 1.8 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EFA82254.1 - 2e-19 69.7 5.6 5.6e-19 68.2 5.6 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EFA82254.1 - 4.4e-09 36.5 10.3 4.4e-09 36.5 10.3 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA82254.1 - 4.8e-07 29.5 9.5 4.8e-07 29.5 9.5 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA82254.1 - 1.9e-06 28.1 6.2 1.9e-06 28.1 6.2 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFA82254.1 - 6.1e-05 23.0 5.7 6.1e-05 23.0 5.7 2.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA82254.1 - 0.0001 22.1 8.4 0.0001 22.1 8.4 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA82254.1 - 0.00022 20.9 5.7 0.00085 19.0 5.7 2.1 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EFA82254.1 - 0.00024 21.0 7.9 0.00024 21.0 7.9 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFA82254.1 - 0.0017 18.2 7.2 0.0017 18.2 7.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EFA82254.1 - 0.0026 17.5 3.1 0.0026 17.5 3.1 2.1 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EFA82254.1 - 0.006 16.6 6.6 0.006 16.6 6.6 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UBP_var PF17807.1 EFA82254.1 - 0.0093 15.7 1.8 0.015 15.1 0.6 1.9 2 0 0 2 2 2 1 Variant UBP zinc finger PHF5 PF03660.14 EFA82254.1 - 0.9 9.8 13.5 0.48 10.7 9.7 2.6 2 1 1 3 3 3 0 PHF5-like protein DUF4407 PF14362.6 EFA82254.1 - 5.6 6.2 7.9 8.9 5.6 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliD_N PF02465.18 EFA82254.1 - 10 6.9 9.4 1.1 10.0 1.1 2.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4460 PF14687.6 EFA82255.1 - 1.1e-27 96.2 0.2 1.1e-27 96.2 0.2 2.8 3 1 0 3 3 3 1 Domain of unknown function (DUF4460) DUF4461 PF14688.6 EFA82255.1 - 6.9e-09 35.9 7.1 1.7e-07 31.4 7.1 3.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4461) Phage_Arf PF17585.2 EFA82255.1 - 3.1 7.8 6.1 0.15 12.0 0.4 1.8 2 0 0 2 2 2 0 Accessory recombination function protein Ank_2 PF12796.7 EFA82256.1 - 5e-17 62.3 9.3 1e-05 26.0 0.1 7.8 4 3 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82256.1 - 1.6e-12 47.7 3.8 0.06 13.9 0.0 8.2 8 1 1 9 9 9 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82256.1 - 1e-06 28.6 2.4 33 5.5 0.0 9.1 11 0 0 11 11 11 0 Ankyrin repeat Ank_5 PF13857.6 EFA82256.1 - 6e-06 26.4 3.4 1.2 9.5 0.1 6.4 7 0 0 7 7 7 1 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA82256.1 - 0.0013 18.6 18.5 1.6 8.7 0.0 6.8 4 2 3 7 7 7 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA82256.1 - 0.096 13.2 0.7 16 6.1 0.0 4.2 4 1 0 4 4 4 0 Ankyrin repeat CNOT11 PF10155.9 EFA82257.1 - 0.089 13.0 1.1 9.9 6.3 0.0 4.0 2 1 1 3 3 3 0 CCR4-NOT transcription complex subunit 11 TFCD_C PF12612.8 EFA82257.1 - 3.4 7.5 5.1 35 4.1 0.0 4.8 6 0 0 6 6 6 0 Tubulin folding cofactor D C terminal zf-MYND PF01753.18 EFA82258.1 - 4.3e-09 36.3 9.1 7.9e-09 35.5 9.1 1.5 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EFA82258.1 - 0.81 10.0 8.9 1.5 9.2 8.9 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding FliD_N PF02465.18 EFA82258.1 - 2.9 8.7 13.2 0.21 12.3 7.2 2.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Pterin_4a PF01329.19 EFA82258.1 - 4 7.7 8.5 5.5 7.2 3.8 3.2 2 1 1 3 3 3 0 Pterin 4 alpha carbinolamine dehydratase zf-RING_5 PF14634.6 EFA82259.1 - 1.2e-10 41.1 16.6 2.8e-10 40.0 16.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFA82259.1 - 1.8e-05 25.0 15.4 1.8e-05 25.0 15.4 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFA82259.1 - 0.00043 20.1 12.1 0.00043 20.1 12.1 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA82259.1 - 0.00099 18.9 14.2 0.00099 18.9 14.2 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Filament PF00038.21 EFA82259.1 - 0.0012 18.5 10.3 0.0018 17.9 10.3 1.2 1 0 0 1 1 1 1 Intermediate filament protein DUF641 PF04859.12 EFA82259.1 - 0.0045 17.3 5.0 0.0093 16.3 5.0 1.5 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) zf-P11 PF03854.14 EFA82259.1 - 0.0059 16.3 9.5 0.012 15.3 9.5 1.5 1 0 0 1 1 1 1 P-11 zinc finger Prok-RING_4 PF14447.6 EFA82259.1 - 0.015 15.2 12.6 0.015 15.2 12.6 2.2 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 DUF1664 PF07889.12 EFA82259.1 - 0.019 15.0 3.8 0.036 14.1 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2264 PF10022.9 EFA82259.1 - 0.053 12.6 0.3 0.094 11.8 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2264) Fib_alpha PF08702.10 EFA82259.1 - 0.077 13.2 9.9 0.029 14.6 5.8 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family zinc-ribbons_6 PF07191.12 EFA82259.1 - 0.081 12.9 9.3 0.22 11.5 9.3 1.8 1 0 0 1 1 1 0 zinc-ribbons DUF4407 PF14362.6 EFA82259.1 - 0.11 11.8 1.0 0.2 11.0 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 EFA82259.1 - 0.11 11.7 8.0 0.21 10.9 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 EFA82259.1 - 0.16 12.2 8.2 0.27 11.5 8.2 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 IFT20 PF14931.6 EFA82259.1 - 0.17 12.0 8.4 0.38 10.9 8.4 1.5 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF1272 PF06906.11 EFA82259.1 - 0.18 11.9 10.0 0.4 10.8 10.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_6 PF14835.6 EFA82259.1 - 0.34 10.8 5.6 0.63 9.9 5.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein OrfB_IS605 PF01385.19 EFA82259.1 - 0.43 10.8 5.1 0.89 9.8 5.1 1.6 1 1 0 1 1 1 0 Probable transposase zf-C3HC4 PF00097.25 EFA82259.1 - 0.54 10.2 19.5 0.1 12.5 15.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FapA PF03961.13 EFA82259.1 - 0.79 8.3 5.9 1.3 7.6 5.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-RING_UBOX PF13445.6 EFA82259.1 - 1.3 9.1 10.0 0.55 10.3 6.0 2.4 1 1 1 2 2 2 0 RING-type zinc-finger TMPIT PF07851.13 EFA82259.1 - 2.9 7.0 11.0 0.086 12.1 4.9 1.5 2 0 0 2 2 2 0 TMPIT-like protein zf-rbx1 PF12678.7 EFA82259.1 - 3.2 8.1 17.9 0.59 10.5 13.8 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 EFA82259.1 - 7.7 6.5 9.8 80 3.2 9.0 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Peptidase_M16_C PF05193.21 EFA82260.1 - 8.5e-17 61.8 0.8 6e-14 52.5 0.1 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFA82260.1 - 2.4e-11 43.8 8.0 7.9e-10 38.9 0.0 4.3 4 1 1 5 5 5 2 Insulinase (Peptidase family M16) Sec23_trunk PF04811.15 EFA82261.1 - 3.5e-21 75.9 0.1 5.7e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 EFA82261.1 - 3.2e-06 27.1 2.0 7.1e-06 26.0 2.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EFA82261.1 - 4.3e-05 24.2 0.1 0.00013 22.6 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain RR_TM4-6 PF06459.12 EFA82262.1 - 0.0012 18.7 17.1 0.0015 18.4 17.1 1.0 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 EFA82262.1 - 0.058 14.1 26.3 0.091 13.4 26.3 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4746 PF15928.5 EFA82262.1 - 0.069 12.6 8.6 0.08 12.4 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIA PF03153.13 EFA82262.1 - 0.085 12.8 44.7 0.11 12.4 44.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 EFA82262.1 - 0.089 10.7 16.7 0.091 10.7 16.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 EFA82262.1 - 0.13 11.0 16.4 0.14 10.9 16.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 EFA82262.1 - 0.16 10.8 14.8 0.18 10.6 14.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein LicD PF04991.13 EFA82262.1 - 0.25 11.4 9.2 0.32 11.1 9.2 1.1 1 0 0 1 1 1 0 LicD family DUF572 PF04502.13 EFA82262.1 - 0.33 10.5 18.0 0.39 10.3 18.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Exonuc_VII_L PF02601.15 EFA82262.1 - 0.34 10.4 19.8 0.35 10.4 19.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pal1 PF08316.11 EFA82262.1 - 0.4 11.5 10.8 0.5 11.1 10.8 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein SLC12 PF03522.15 EFA82262.1 - 0.59 9.1 20.3 0.62 9.0 20.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Endostatin PF06482.11 EFA82262.1 - 0.72 9.3 20.0 0.83 9.1 20.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Cellulose_synt PF03552.14 EFA82262.1 - 0.73 8.2 7.3 0.76 8.2 7.3 1.0 1 0 0 1 1 1 0 Cellulose synthase Radical_SAM_N PF08497.10 EFA82262.1 - 0.74 9.0 9.5 0.81 8.9 9.5 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal Neur_chan_memb PF02932.16 EFA82262.1 - 0.76 9.8 16.2 1.1 9.3 16.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF-3_zeta PF05091.12 EFA82262.1 - 0.89 8.5 23.9 1 8.2 23.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 EFA82262.1 - 1 9.3 14.8 1.3 9.0 14.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 EFA82262.1 - 1.2 7.8 24.8 1.4 7.6 24.8 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 EFA82262.1 - 1.6 7.0 9.5 1.6 7.0 9.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BORG_CEP PF14957.6 EFA82262.1 - 1.8 9.8 13.0 2.6 9.2 13.0 1.4 1 0 0 1 1 1 0 Cdc42 effector Gti1_Pac2 PF09729.9 EFA82262.1 - 2.2 8.3 20.2 3.4 7.7 20.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family FAM222A PF15258.6 EFA82262.1 - 3.4 6.7 35.1 3.9 6.5 35.1 1.1 1 0 0 1 1 1 0 Protein family of FAM222A Hid1 PF12722.7 EFA82262.1 - 4.1 5.4 22.3 4.2 5.4 22.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 EFA82262.1 - 4.2 6.5 11.2 4.6 6.3 11.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 EFA82262.1 - 5.1 4.1 22.4 5 4.1 22.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Band_3_cyto PF07565.13 EFA82262.1 - 5.5 6.7 20.1 6.6 6.4 20.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF853 PF05872.12 EFA82262.1 - 5.6 5.4 15.8 6.4 5.2 15.8 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Serinc PF03348.15 EFA82262.1 - 6.2 5.6 9.2 7.2 5.4 9.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S64 PF08192.11 EFA82262.1 - 6.4 5.1 22.8 7.5 4.9 22.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 Gastrin PF00918.17 EFA82262.1 - 6.4 7.8 18.1 10 7.1 18.1 1.3 1 0 0 1 1 1 0 Gastrin/cholecystokinin family PAT1 PF09770.9 EFA82262.1 - 6.5 4.9 38.0 9.1 4.4 38.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Glyco_transf_41 PF13844.6 EFA82262.1 - 9.4 4.5 14.6 9.7 4.5 14.6 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 Peptidase_M3 PF01432.20 EFA82263.1 - 8.5e-95 318.7 2.1 7.1e-84 282.7 1.9 2.1 2 0 0 2 2 2 2 Peptidase family M3 Peptidase_M50B PF13398.6 EFA82263.1 - 0.24 11.0 1.7 0.54 9.9 1.7 1.5 1 0 0 1 1 1 0 Peptidase M50B-like ABC_tran PF00005.27 EFA82264.1 - 1.7e-29 103.1 0.2 3.6e-29 102.0 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA82264.1 - 1.1e-18 67.4 36.9 1.1e-18 67.4 36.9 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA82264.1 - 5.2e-13 49.5 0.1 1.2e-07 31.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFA82264.1 - 0.0059 17.1 0.2 0.0059 17.1 0.2 1.7 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EFA82264.1 - 0.0097 15.6 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_29 PF13555.6 EFA82264.1 - 0.14 11.9 0.2 0.33 10.7 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane PF01061.24 EFA82264.1 - 0.24 10.8 33.9 0.036 13.5 29.4 1.8 1 1 0 1 1 1 0 ABC-2 type transporter ABC2_membrane_2 PF12679.7 EFA82264.1 - 0.66 9.2 19.6 1.5 8.0 19.6 1.6 1 0 0 1 1 1 0 ABC-2 family transporter protein STATa_Ig PF18214.1 EFA82265.1 - 2.1e-46 156.9 0.6 2.1e-46 156.9 0.6 2.2 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain Dict-STAT-coil PF09267.10 EFA82265.1 - 2.2e-45 153.7 14.6 2.2e-45 153.7 14.6 2.8 3 0 0 3 3 3 1 Dictyostelium STAT, coiled coil EF-hand_12 PF17901.1 EFA82265.1 - 8e-42 141.6 4.8 8e-42 141.6 4.8 2.6 2 0 0 2 2 2 1 EF-hand fold domain SH2 PF00017.24 EFA82265.1 - 6.8e-09 35.7 0.0 2e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Cbl_N3 PF02762.14 EFA82265.1 - 0.016 15.0 0.0 0.06 13.2 0.0 1.9 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Presenilin PF01080.17 EFA82265.1 - 4.3 6.0 7.7 5.9 5.6 7.7 1.2 1 0 0 1 1 1 0 Presenilin Kelch_6 PF13964.6 EFA82266.1 - 1.1e-14 54.1 1.9 3.1e-05 24.1 0.0 5.8 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFA82266.1 - 8.1e-06 25.3 1.1 0.29 10.8 0.3 4.5 4 0 0 4 4 4 1 Kelch motif zf-B_box PF00643.24 EFA82266.1 - 0.0001 22.3 7.6 0.00024 21.2 7.6 1.6 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA82266.1 - 0.00062 19.7 8.2 2.7 8.1 0.1 5.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA82266.1 - 0.003 17.5 1.1 0.51 10.4 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 EFA82266.1 - 0.29 11.2 9.3 0.48 10.5 0.7 3.4 3 0 0 3 3 3 0 Kelch motif TIG PF01833.24 EFA82267.1 - 3.3e-16 59.1 39.8 1.9e-05 24.7 5.1 7.3 7 0 0 7 7 7 5 IPT/TIG domain EGF_2 PF07974.13 EFA82267.1 - 0.0062 16.9 8.7 0.021 15.2 8.7 1.9 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EFA82267.1 - 0.57 10.9 8.8 0.16 12.7 4.6 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF PhyH PF05721.13 EFA82268.1 - 1.2e-29 104.1 0.2 1.6e-29 103.7 0.2 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) SLX9 PF15341.6 EFA82269.1 - 1.8e-20 73.7 15.7 1.8e-20 73.7 15.7 2.5 3 0 0 3 3 3 1 Ribosome biogenesis protein SLX9 BNIP2 PF12496.8 EFA82269.1 - 0.3 11.5 6.6 0.052 14.0 2.2 2.1 2 1 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 PRP1_N PF06424.12 EFA82269.1 - 4.2 7.8 22.3 0.59 10.5 16.4 2.5 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal HlyIII PF03006.20 EFA82270.1 - 5.8e-15 55.6 5.4 7.4e-15 55.3 5.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related LRRC37AB_C PF14914.6 EFA82270.1 - 0.89 9.5 6.2 1.5 8.8 6.2 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain RRM_1 PF00076.22 EFA82271.1 - 0.00017 21.3 0.0 0.00031 20.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 EFA82271.1 - 0.004 17.0 0.0 0.0081 16.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) Peptidase_S64 PF08192.11 EFA82271.1 - 7.7 4.9 21.3 11 4.4 21.3 1.3 1 0 0 1 1 1 0 Peptidase family S64 CH PF00307.31 EFA82272.1 - 9.8e-14 51.5 0.0 9.8e-14 51.5 0.0 3.8 4 0 0 4 4 4 1 Calponin homology (CH) domain Adeno_E1B_55K_N PF04623.12 EFA82272.1 - 0.073 13.8 4.0 0.18 12.6 4.0 1.6 1 0 0 1 1 1 0 Adenovirus E1B protein N-terminus DUF4730 PF15873.5 EFA82273.1 - 4.3e-06 26.9 0.1 4.9e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4730) MgtE PF01769.16 EFA82273.1 - 0.06 13.7 2.9 0.068 13.5 2.9 1.0 1 0 0 1 1 1 0 Divalent cation transporter DUF4750 PF15938.5 EFA82273.1 - 0.08 12.6 1.8 0.13 12.0 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) Ank_4 PF13637.6 EFA82274.1 - 1.8e-21 76.2 5.7 7.5e-06 26.4 0.0 6.1 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA82274.1 - 4.3e-18 65.7 1.9 1.6e-05 25.4 0.2 4.3 2 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA82274.1 - 1e-11 44.8 14.7 0.049 14.0 0.0 7.8 5 1 4 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82274.1 - 7e-10 38.3 4.9 5.5 7.9 0.0 9.2 10 0 0 10 10 10 2 Ankyrin repeat DUF249 PF03158.13 EFA82274.1 - 0.68 9.6 3.4 5.5 6.7 0.1 3.6 3 1 1 4 4 4 0 Multigene family 530 protein zf-C2H2_6 PF13912.6 EFA82276.1 - 0.12 12.4 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger EGF_2 PF07974.13 EFA82277.1 - 0.00037 20.8 11.8 0.00082 19.7 11.8 1.6 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA82277.1 - 0.08 13.3 9.6 0.21 11.9 9.6 1.8 1 0 0 1 1 1 0 EGF-like domain SKG6 PF08693.10 EFA82277.1 - 0.74 9.3 4.0 1.5 8.3 4.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LapA_dom PF06305.11 EFA82277.1 - 2.4 8.0 3.9 0.6 10.0 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Mito_carr PF00153.27 EFA82278.1 - 2.8e-64 213.1 1.9 1.9e-20 72.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFA82278.1 - 0.00036 19.8 0.4 0.0089 15.2 0.0 3.0 3 1 1 4 4 4 1 Gammaproteobacterial serine protease CRAL_TRIO PF00650.20 EFA82279.1 - 1.4e-45 154.9 0.0 1.8e-45 154.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFA82279.1 - 5.1e-10 39.4 1.0 1.2e-09 38.2 1.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFA82279.1 - 2.5e-06 27.7 0.1 3.8e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Peptidase_M50 PF02163.22 EFA82280.1 - 3.3e-15 56.1 0.1 3e-13 49.7 0.1 2.7 1 1 0 1 1 1 1 Peptidase family M50 DUF3013 PF11217.8 EFA82280.1 - 0.053 13.4 0.2 0.098 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3013) FAA_hydrolase PF01557.18 EFA82281.1 - 5.2e-61 206.1 0.0 6.1e-61 205.9 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family KH_2 PF07650.17 EFA82281.1 - 0.027 14.3 0.2 0.052 13.4 0.2 1.5 1 0 0 1 1 1 0 KH domain UQ_con PF00179.26 EFA82283.1 - 3.3e-19 68.9 0.1 4e-19 68.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ank_4 PF13637.6 EFA82284.1 - 9.7e-34 115.3 9.4 1.1e-11 45.0 0.3 4.9 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA82284.1 - 5.1e-30 103.9 4.8 4.4e-18 65.7 0.4 3.9 3 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFA82284.1 - 8.2e-28 95.6 7.5 3.9e-08 33.4 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFA82284.1 - 8.7e-27 90.2 2.0 1.7e-05 24.8 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFA82284.1 - 3.6e-24 84.5 3.0 1.3e-08 34.9 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Bromodomain PF00439.25 EFA82284.1 - 5.6e-21 74.4 0.2 1.5e-20 73.0 0.2 1.8 1 0 0 1 1 1 1 Bromodomain BTB PF00651.31 EFA82284.1 - 8.8e-21 74.2 0.9 2.5e-20 72.8 0.9 1.8 1 0 0 1 1 1 1 BTB/POZ domain BET PF17035.5 EFA82284.1 - 9.6e-11 41.7 3.2 9.6e-11 41.7 3.2 2.3 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation DUF908 PF06012.12 EFA82284.1 - 0.019 14.4 32.1 0.021 14.2 3.2 3.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF908) PRCC PF10253.9 EFA82284.1 - 0.76 10.5 45.1 0.38 11.5 2.0 3.2 3 0 0 3 3 3 0 Mitotic checkpoint regulator, MAD2B-interacting Macoilin PF09726.9 EFA82284.1 - 4 5.9 34.2 0.66 8.5 3.3 3.1 3 0 0 3 3 3 0 Macoilin family BRCT PF00533.26 EFA82285.1 - 9.1e-11 42.0 0.2 8.1e-08 32.5 0.2 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA82285.1 - 5.5e-10 39.5 0.3 0.00073 19.9 0.0 3.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RAMA PF18755.1 EFA82285.1 - 8.1e-10 39.1 0.0 2.6e-09 37.4 0.0 1.9 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated PTCB-BRCT PF12738.7 EFA82285.1 - 9.7e-06 25.4 0.1 2.8e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 EFA82285.1 - 0.14 12.1 2.8 0.33 10.8 0.0 3.0 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain Homeobox_KN PF05920.11 EFA82286.1 - 1.3e-06 28.1 0.1 3.2e-06 26.9 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFA82286.1 - 0.00052 19.8 0.9 0.00052 19.8 0.9 2.0 2 0 0 2 2 2 1 Homeodomain Spore_coat_CotO PF14153.6 EFA82286.1 - 0.32 10.9 21.2 0.5 10.3 0.8 2.5 1 1 1 2 2 2 0 Spore coat protein CotO PA14 PF07691.12 EFA82287.1 - 3.8e-12 46.2 0.0 6e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 PA14 domain NUC205 PF08168.11 EFA82287.1 - 0.014 14.9 64.4 0.31 10.6 1.9 8.8 8 1 0 8 8 8 0 NUC205 domain COX6B PF02297.17 EFA82288.1 - 0.018 15.3 2.9 0.19 12.0 0.9 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb DUF725 PF05267.12 EFA82288.1 - 0.025 14.5 0.1 0.032 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF725) PEN-2 PF10251.9 EFA82289.1 - 1.6e-26 92.5 6.9 1.9e-26 92.3 6.9 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Med18 PF09637.10 EFA82291.1 - 2.5e-06 27.5 0.9 2.9e-06 27.3 0.9 1.3 1 1 0 1 1 1 1 Med18 protein bHLH-MYC_N PF14215.6 EFA82291.1 - 0.069 13.4 0.3 0.1 12.9 0.3 1.4 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal Endotoxin_N PF03945.14 EFA82292.1 - 2.8e-25 89.4 1.3 4.7e-25 88.6 1.3 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Endotoxin_N PF03945.14 EFA82293.1 - 3.2e-35 121.9 1.2 5.4e-35 121.1 1.2 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain Amidase02_C PF12123.8 EFA82293.1 - 0.013 15.1 0.4 1.8 8.3 0.0 2.7 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase Ge1_WD40 PF16529.5 EFA82293.1 - 0.025 13.6 0.4 0.041 12.8 0.4 1.2 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Carb_bind PF10645.9 EFA82294.1 - 0.19 11.9 16.7 0.2 11.9 13.4 2.4 1 1 1 2 2 2 0 Carbohydrate binding Integrin_alpha PF00357.20 EFA82294.1 - 0.5 10.5 5.1 13 6.1 0.4 2.6 2 0 0 2 2 2 0 Integrin alpha cytoplasmic region IGFL PF14653.6 EFA82294.1 - 1.1 9.2 10.6 1.1 9.3 2.0 2.1 1 1 1 2 2 2 0 Insulin growth factor-like family 5_nucleotid PF05761.14 EFA82296.1 - 4.3e-147 490.7 5.0 5.9e-147 490.3 5.0 1.2 1 0 0 1 1 1 1 5' nucleotidase family DUF2229 PF09989.9 EFA82296.1 - 0.12 12.0 0.1 8.2 6.0 0.0 2.5 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Ank_2 PF12796.7 EFA82297.1 - 6e-38 129.3 10.6 3.2e-14 53.3 0.7 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 EFA82297.1 - 4.9e-28 97.9 5.2 4.9e-28 97.9 5.2 2.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_3 PF13606.6 EFA82297.1 - 1.8e-26 89.3 2.6 3.6e-05 23.8 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EFA82297.1 - 9.6e-26 89.8 2.8 1.4e-11 44.7 0.3 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA82297.1 - 1.7e-24 85.1 5.4 0.00064 20.1 0.1 5.5 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EFA82297.1 - 5.5e-24 83.9 5.2 1.5e-06 28.3 0.1 5.2 3 2 2 5 5 5 4 Ankyrin repeats (many copies) zf-B_box PF00643.24 EFA82298.1 - 0.0064 16.6 8.5 0.011 15.8 8.5 1.4 1 0 0 1 1 1 1 B-box zinc finger PTS_IIA PF02255.16 EFA82298.1 - 0.091 12.8 1.6 0.18 11.9 1.6 1.5 1 1 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit BTB PF00651.31 EFA82299.1 - 2.5e-13 50.2 0.7 5.6e-13 49.1 0.7 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EFA82299.1 - 7.2e-06 26.0 0.2 0.017 15.2 0.1 2.8 2 1 0 2 2 2 2 BTB And C-terminal Kelch zf-B_box PF00643.24 EFA82300.1 - 0.006 16.7 13.4 0.0098 16.0 13.4 1.4 1 0 0 1 1 1 1 B-box zinc finger ArfGap PF01412.18 EFA82300.1 - 0.24 11.5 9.2 0.44 10.6 9.1 1.4 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf DUF4407 PF14362.6 EFA82301.1 - 0.038 13.3 4.1 0.12 11.7 3.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ETRAMP PF09716.10 EFA82301.1 - 0.039 14.0 0.7 0.039 14.0 0.7 5.3 4 1 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) SpoIIIAH PF12685.7 EFA82301.1 - 0.098 12.5 29.8 0.37 10.6 0.2 3.4 3 0 0 3 3 3 0 SpoIIIAH-like protein Sec62 PF03839.16 EFA82301.1 - 0.34 10.4 11.4 3.6 7.0 9.4 3.1 3 0 0 3 3 3 0 Translocation protein Sec62 Zip PF02535.22 EFA82301.1 - 0.39 9.9 7.6 0.46 9.6 5.2 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EFA82301.1 - 1.9 8.5 12.1 15 5.6 12.7 2.0 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SprA-related PF12118.8 EFA82301.1 - 4.2 6.4 23.9 0.035 13.2 13.3 2.5 3 0 0 3 3 3 0 SprA-related family pXO2-72 PF17443.2 EFA82302.1 - 0.2 11.9 3.8 0.93 9.8 0.2 2.8 2 0 0 2 2 2 0 Uncharacterized protein pXO2-72 APG6_N PF17675.1 EFA82302.1 - 1.9 9.0 0.0 1.9 9.0 0.0 6.6 4 1 1 6 6 6 0 Apg6 coiled-coil region DUF202 PF02656.15 EFA82303.1 - 2.4e-11 43.9 4.9 3.8e-11 43.3 4.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF202) DUF2207 PF09972.9 EFA82303.1 - 0.0017 17.2 0.0 0.0019 17.1 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) TGF_beta_GS PF08515.12 EFA82303.1 - 0.047 13.2 2.7 0.047 13.2 2.7 2.4 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif DUF4366 PF14283.6 EFA82303.1 - 0.052 13.6 0.1 4.3 7.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF3720 PF12517.8 EFA82303.1 - 0.29 12.1 2.8 0.56 11.2 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) Serglycin PF04360.12 EFA82303.1 - 1 9.3 7.6 1.9 8.4 2.1 2.2 1 1 1 2 2 2 0 Serglycin SR-25 PF10500.9 EFA82303.1 - 2 7.9 16.0 3.9 7.0 16.0 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein PhoLip_ATPase_C PF16212.5 EFA82304.1 - 2.4e-68 230.6 29.2 2.4e-68 230.6 29.2 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA82304.1 - 5.2e-14 51.7 3.0 5.2e-14 51.7 3.0 2.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFA82304.1 - 1.7e-12 48.1 0.0 2.7e-06 27.8 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA82304.1 - 1.6e-11 44.1 0.0 3.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFA82304.1 - 3e-06 26.9 1.9 3e-06 26.9 1.9 3.4 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFA82304.1 - 0.0014 18.4 0.2 0.012 15.3 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA82304.1 - 0.11 12.9 0.0 1.9 8.9 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase TPR_2 PF07719.17 EFA82305.1 - 7.8e-17 60.0 5.3 0.0039 17.2 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFA82305.1 - 1e-16 59.9 6.0 0.00049 19.8 0.6 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFA82305.1 - 7.1e-10 38.9 4.6 0.29 12.0 0.1 6.2 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA82305.1 - 1.3e-08 34.4 0.1 0.00039 20.0 0.0 3.1 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.6 EFA82305.1 - 1.7e-08 35.0 0.5 0.00039 21.0 0.1 4.2 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA82305.1 - 9.3e-08 31.7 1.4 2.9 8.3 0.4 5.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA82305.1 - 2.1e-07 30.8 2.2 0.083 13.3 0.1 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFA82305.1 - 2.1e-06 27.8 4.3 1.2e-05 25.3 0.4 3.7 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA82305.1 - 4e-05 23.8 7.5 0.54 10.6 0.2 5.0 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA82305.1 - 6.1e-05 23.4 0.2 0.94 10.0 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFA82305.1 - 0.0001 21.7 0.1 0.62 9.2 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA82305.1 - 0.00098 19.0 1.9 0.5 10.5 0.0 5.3 6 1 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA82305.1 - 0.013 15.7 0.3 0.013 15.7 0.3 3.5 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFA82305.1 - 0.34 10.8 8.4 15 5.6 0.6 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2828 PF11443.8 EFA82306.1 - 0.0033 15.6 1.1 0.0034 15.6 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) GATA PF00320.27 EFA82306.1 - 0.15 11.7 0.3 0.15 11.7 0.3 2.3 2 0 0 2 2 2 0 GATA zinc finger Roughex PF06020.11 EFA82306.1 - 0.36 9.9 3.5 0.42 9.7 3.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein MPM1 PF17234.2 EFA82306.1 - 0.79 10.0 15.5 0.21 11.8 12.0 1.7 1 1 1 2 2 2 0 Mitochondrial peculiar membrane protein 1 Presenilin PF01080.17 EFA82306.1 - 0.85 8.3 4.6 1 8.0 4.6 1.2 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.13 EFA82306.1 - 1.8 7.3 9.6 2.4 6.9 9.6 1.3 1 1 0 1 1 1 0 Otopetrin tRNA-synt_1 PF00133.22 EFA82307.1 - 5.9e-175 583.0 0.1 9.7e-175 582.3 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFA82307.1 - 5.3e-22 78.4 0.2 1e-21 77.5 0.2 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFA82307.1 - 3.8e-21 75.3 0.0 1.8e-13 50.0 0.0 3.6 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFA82307.1 - 0.00045 19.6 0.4 1.7 8.0 0.0 3.5 2 1 1 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 EFA82307.1 - 0.00051 19.6 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 zf-FPG_IleRS PF06827.14 EFA82307.1 - 0.03 14.2 8.3 0.064 13.1 8.3 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS BACK PF07707.15 EFA82308.1 - 5.5e-05 23.2 0.1 0.15 12.2 0.0 2.2 2 0 0 2 2 2 2 BTB And C-terminal Kelch RT_RNaseH PF17917.1 EFA82309.1 - 1.2e-12 48.1 0.0 1.8e-06 28.2 0.0 2.5 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase TIG PF01833.24 EFA82309.1 - 7.5e-11 42.0 55.6 7.5e-06 25.9 6.0 5.8 5 0 0 5 5 5 4 IPT/TIG domain RT_RNaseH_2 PF17919.1 EFA82309.1 - 1.4e-10 41.1 0.0 2.9e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-B_box PF00643.24 EFA82310.1 - 0.00038 20.5 3.0 0.00038 20.5 3.0 1.6 2 0 0 2 2 2 1 B-box zinc finger ArfGap PF01412.18 EFA82310.1 - 0.16 12.0 4.4 0.25 11.4 4.4 1.5 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf BLI1 PF17324.2 EFA82311.1 - 2.4 8.8 9.4 0.42 11.3 5.2 1.8 2 0 0 2 2 2 0 BLOC-1 interactor 1 HTH_WhiA PF02650.14 EFA82312.1 - 0.06 13.7 0.0 0.065 13.6 0.0 1.1 1 0 0 1 1 1 0 WhiA C-terminal HTH domain Gag_p17 PF00540.18 EFA82313.1 - 0.058 13.4 0.4 0.071 13.1 0.4 1.1 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) Androgen_recep PF02166.16 EFA82313.1 - 0.074 11.9 2.6 0.08 11.8 2.6 1.1 1 0 0 1 1 1 0 Androgen receptor N2227 PF07942.12 EFA82314.1 - 1.5e-18 67.0 0.0 2.7e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 N2227-like protein Sigma70_ner PF04546.13 EFA82314.1 - 0.093 12.6 1.1 0.4 10.5 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region N2227 PF07942.12 EFA82315.1 - 1.5e-16 60.4 0.6 1.7e-16 60.2 0.6 1.0 1 0 0 1 1 1 1 N2227-like protein NADH-UOR_E PF16514.5 EFA82315.1 - 0.02 15.2 0.1 0.04 14.2 0.1 1.5 1 0 0 1 1 1 0 putative NADH-ubiquinone oxidoreductase chain E Methyltransf_11 PF08241.12 EFA82315.1 - 0.027 15.1 0.0 0.045 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFA82315.1 - 0.041 14.6 0.0 0.079 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EFA82315.1 - 0.13 13.0 0.0 0.26 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cyclin PF08613.11 EFA82316.1 - 0.00021 21.7 0.1 0.00036 20.9 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFA82316.1 - 0.0038 17.0 0.1 0.0062 16.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain GATA PF00320.27 EFA82317.1 - 0.013 15.1 0.3 0.018 14.6 0.3 1.3 1 0 0 1 1 1 0 GATA zinc finger Cyclin_N PF00134.23 EFA82318.1 - 0.0014 18.3 0.2 0.0029 17.4 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF4214 PF13946.6 EFA82318.1 - 0.0021 18.1 0.2 0.0041 17.1 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4214) Cyclin PF08613.11 EFA82318.1 - 0.96 9.8 5.0 0.19 12.1 1.5 1.7 2 0 0 2 2 2 0 Cyclin PBECR3 PF18812.1 EFA82318.1 - 2.6 8.0 6.5 0.32 11.0 1.3 2.2 2 1 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 TIG PF01833.24 EFA82320.1 - 6.8e-18 64.5 58.8 3.8e-05 23.7 6.0 6.4 5 1 1 6 6 6 6 IPT/TIG domain IL6Ra-bind PF09240.10 EFA82320.1 - 0.0017 18.7 0.8 0.86 10.1 0.0 3.7 4 0 0 4 4 4 1 Interleukin-6 receptor alpha chain, binding TIG PF01833.24 EFA82321.1 - 1.2e-09 38.0 52.5 1e-05 25.5 4.4 5.5 5 0 0 5 5 5 5 IPT/TIG domain BACK PF07707.15 EFA82322.1 - 0.0014 18.7 0.0 1.1 9.3 0.0 2.6 2 0 0 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.31 EFA82322.1 - 0.0054 17.0 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Cyclin_N PF00134.23 EFA82325.1 - 2.6e-05 24.0 0.3 3.7e-05 23.5 0.3 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain GDPD PF03009.17 EFA82325.1 - 0.15 11.8 0.3 0.19 11.4 0.3 1.2 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family FYVE_2 PF02318.16 EFA82326.1 - 0.0041 17.3 9.7 0.011 16.0 4.1 2.6 2 1 1 3 3 3 1 FYVE-type zinc finger DUF4710 PF15828.5 EFA82326.1 - 0.03 14.4 0.4 0.047 13.8 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) zf-B_box PF00643.24 EFA82326.1 - 0.04 14.1 9.6 0.072 13.3 9.6 1.4 1 0 0 1 1 1 0 B-box zinc finger DUF3763 PF12592.8 EFA82326.1 - 0.071 13.2 0.2 0.071 13.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3763) zf-RING_2 PF13639.6 EFA82326.1 - 3.5 8.0 9.0 6.5 7.2 9.0 1.5 1 0 0 1 1 1 0 Ring finger domain DUF4637 PF15470.6 EFA82326.1 - 5.2 6.8 8.3 0.39 10.4 2.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Dicty_REP PF05086.12 EFA82327.1 - 0.17 9.8 14.7 0.22 9.4 14.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 EFA82327.1 - 1.5 8.8 32.9 0.2 11.6 20.4 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein GATA PF00320.27 EFA82328.1 - 2.8e-07 30.0 2.7 5.3e-07 29.1 2.7 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EFA82328.1 - 0.056 13.0 0.5 0.15 11.6 0.5 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding Stevor PF17410.2 EFA82330.1 - 0.058 12.9 1.3 0.1 12.1 1.3 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DDE_3 PF13358.6 EFA82331.1 - 1.1e-06 28.4 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS240 PF13610.6 EFA82331.1 - 0.0088 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 DDE domain RVT_1 PF00078.27 EFA82332.1 - 0.0013 18.3 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MARVEL PF01284.23 EFA82335.1 - 0.57 10.2 6.0 1.8 8.6 6.0 1.9 1 1 0 1 1 1 0 Membrane-associating domain zf-NF-X1 PF01422.17 EFA82337.1 - 0.0002 21.3 13.5 0.0002 21.3 13.5 15.2 14 1 1 15 15 15 10 NF-X1 type zinc finger Vps53_N PF04100.12 EFA82338.1 - 3.7e-112 375.1 11.9 5.7e-112 374.4 11.9 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 EFA82338.1 - 8.1e-12 45.0 8.4 8.1e-12 45.0 8.4 2.0 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex Sec6 PF06046.13 EFA82338.1 - 1e-06 27.4 8.0 0.0004 18.9 0.5 3.3 2 2 0 2 2 2 2 Exocyst complex component Sec6 COG5 PF10392.9 EFA82338.1 - 1.8e-05 24.9 4.3 0.00042 20.5 2.7 3.2 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Spc7 PF08317.11 EFA82338.1 - 0.0021 17.0 6.0 0.0021 17.0 6.0 2.0 2 1 1 3 3 3 1 Spc7 kinetochore protein COG7 PF10191.9 EFA82338.1 - 0.0027 16.0 7.0 0.023 12.9 0.0 2.6 2 1 0 2 2 2 1 Golgi complex component 7 (COG7) XhlA PF10779.9 EFA82338.1 - 0.0032 17.6 3.6 0.0032 17.6 3.6 4.0 5 0 0 5 5 5 1 Haemolysin XhlA COG2 PF06148.11 EFA82338.1 - 0.025 14.7 7.0 0.67 10.1 5.7 3.2 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CEP63 PF17045.5 EFA82338.1 - 0.025 14.5 5.2 0.067 13.1 5.2 1.7 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa SAM_1 PF00536.30 EFA82338.1 - 0.034 14.6 0.3 0.23 11.9 0.1 2.3 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Cnl2_NKP2 PF09447.10 EFA82338.1 - 0.081 13.1 1.6 0.22 11.7 0.1 2.4 2 0 0 2 2 2 0 Cnl2/NKP2 family protein RAM PF15320.6 EFA82338.1 - 4.5 8.0 7.6 6.5 7.4 0.0 2.5 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein Vps51 PF08700.11 EFA82338.1 - 5.7 7.1 7.1 7.5 6.7 0.1 4.0 4 1 0 4 4 4 0 Vps51/Vps67 SLAC1 PF03595.17 EFA82339.1 - 1.6e-06 27.6 12.3 2e-06 27.3 12.3 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF645 PF04875.12 EFA82339.1 - 1.1 9.4 4.9 2.2 8.4 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF645 Vpu PF00558.19 EFA82339.1 - 4.3 7.2 5.5 1.5 8.6 1.0 2.0 2 0 0 2 2 2 0 Vpu protein DUF3561 PF12084.8 EFA82339.1 - 6 6.9 13.0 0.78 9.8 4.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3561) RRN3 PF05327.11 EFA82340.1 - 0.09 11.3 4.5 0.13 10.8 4.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DbpA PF03880.15 EFA82341.1 - 0.045 13.8 0.0 0.27 11.2 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain F-box-like PF12937.7 EFA82341.1 - 0.23 11.4 3.5 0.2 11.6 1.1 2.3 2 0 0 2 2 2 0 F-box-like RuvB_C PF05491.13 EFA82342.1 - 0.0093 15.8 0.0 0.056 13.3 0.0 2.5 2 0 0 2 2 2 1 RuvB C-terminal winged helix domain TPR_2 PF07719.17 EFA82342.1 - 0.012 15.7 4.1 0.032 14.3 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DEAD PF00270.29 EFA82342.1 - 0.029 14.1 0.2 0.19 11.5 0.1 2.6 3 0 0 3 3 3 0 DEAD/DEAH box helicase Mucin PF01456.17 EFA82342.1 - 4.4 7.3 12.3 12 5.9 12.3 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein Cyclin PF08613.11 EFA82344.1 - 0.00028 21.3 0.1 0.00042 20.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin RIO1 PF01163.22 EFA82344.1 - 0.081 12.5 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 RIO1 family TIG PF01833.24 EFA82345.1 - 1.4e-14 53.9 41.5 2.8e-06 27.3 4.5 5.4 4 1 1 5 5 5 5 IPT/TIG domain Cyclin_N PF00134.23 EFA82346.1 - 0.00081 19.1 1.0 0.0014 18.4 1.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain LRR_8 PF13855.6 EFA82347.1 - 4e-14 52.1 42.8 5.9e-09 35.6 7.3 3.8 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFA82347.1 - 6e-05 23.3 42.3 0.0019 18.6 4.4 5.0 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) DUF4813 PF16072.5 EFA82347.1 - 0.48 10.0 9.5 0.52 9.9 8.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4813) LRR_6 PF13516.6 EFA82347.1 - 0.99 9.6 20.1 2.5 8.4 1.0 5.5 5 0 0 5 5 5 0 Leucine Rich repeat Abhydrolase_1 PF00561.20 EFA82348.1 - 1.1e-21 77.7 0.2 3.1e-17 63.1 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA82348.1 - 2.9e-13 50.9 0.0 4.6e-13 50.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA82348.1 - 0.00056 19.2 0.0 0.0043 16.3 0.0 2.2 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Esterase PF00756.20 EFA82348.1 - 0.0012 18.6 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 EFA82348.1 - 0.0027 17.5 0.1 0.0077 16.0 0.1 1.8 1 1 0 1 1 1 1 PGAP1-like protein Lipase PF00151.19 EFA82348.1 - 0.0062 15.9 4.6 0.0099 15.2 0.2 2.3 2 1 0 2 2 2 1 Lipase Thioesterase PF00975.20 EFA82348.1 - 0.013 15.6 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain BAAT_C PF08840.11 EFA82348.1 - 0.017 15.0 5.1 0.035 14.0 0.0 2.8 2 1 1 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.25 EFA82348.1 - 0.14 12.1 0.1 0.71 9.7 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 3) Pet20 PF08692.10 EFA82348.1 - 5 7.8 7.5 14 6.4 0.3 3.1 3 0 0 3 3 3 0 Mitochondrial protein Pet20 TIG PF01833.24 EFA82349.1 - 1.6e-15 56.9 50.0 1.4e-05 25.0 3.2 6.3 5 2 1 6 6 6 5 IPT/TIG domain DUF2236 PF09995.9 EFA82350.1 - 6.2e-06 26.6 0.0 9.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Cass2 PF14526.6 EFA82350.1 - 0.18 12.0 2.6 0.41 10.8 0.9 2.4 2 0 0 2 2 2 0 Integron-associated effector binding protein DUF2236 PF09995.9 EFA82351.1 - 8.4e-06 26.1 0.0 1.2e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) MMS1_N PF10433.9 EFA82352.1 - 3e-88 296.6 4.9 1.6e-56 191.9 3.4 2.4 1 1 1 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFA82352.1 - 3e-68 230.5 0.2 8.1e-66 222.5 0.0 2.9 3 0 0 3 3 3 2 CPSF A subunit region WD40 PF00400.32 EFA82353.1 - 2.4e-14 53.5 10.4 1.1e-05 26.1 0.1 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA82353.1 - 8.8e-10 38.8 0.6 0.23 11.8 0.0 4.5 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PIEZO PF15917.5 EFA82353.1 - 1.2 8.6 13.4 0.97 8.9 8.3 2.3 2 0 0 2 2 2 0 Piezo Band_3_cyto PF07565.13 EFA82353.1 - 1.5 8.6 6.9 0.38 10.5 2.2 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Endonuc_Holl PF10107.9 EFA82353.1 - 1.8 8.4 10.5 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase DUF1911 PF08929.10 EFA82353.1 - 2.1 9.2 7.0 17 6.2 3.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) Presenilin PF01080.17 EFA82353.1 - 4.7 5.9 8.2 0.13 11.0 2.1 1.6 2 0 0 2 2 2 0 Presenilin DUF2054 PF10218.9 EFA82354.1 - 3.2e-42 143.8 20.1 5.3e-42 143.0 20.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) ubiquitin PF00240.23 EFA82355.1 - 7.4e-12 44.8 1.5 1.7e-10 40.5 0.1 2.8 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.8 EFA82355.1 - 1.2e-05 25.0 0.3 0.00017 21.3 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFA82355.1 - 0.0082 16.2 0.1 0.097 12.8 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like SpoVIF PF14069.6 EFA82355.1 - 0.038 13.8 0.4 0.57 10.0 0.0 2.6 2 1 0 2 2 2 0 Stage VI sporulation protein F Ubiquitin_5 PF18037.1 EFA82355.1 - 0.1 13.0 0.3 0.22 11.9 0.1 1.7 2 0 0 2 2 2 0 Ubiquitin-like domain Lig_C PF18330.1 EFA82355.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region zf-RING_2 PF13639.6 EFA82356.1 - 9.9e-10 38.6 7.2 1.7e-09 37.9 7.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFA82356.1 - 2.2e-08 34.2 3.7 9.8e-08 32.2 3.7 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA82356.1 - 8.1e-07 28.8 4.7 1.3e-06 28.1 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA82356.1 - 9.8e-07 28.7 2.2 1.2e-06 28.5 1.0 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA82356.1 - 1.6e-06 27.9 5.7 2.9e-06 27.0 5.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA82356.1 - 6.8e-06 25.8 4.8 1.3e-05 24.9 4.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFA82356.1 - 1.3e-05 24.9 6.6 2.4e-05 24.1 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA82356.1 - 9.4e-05 22.3 4.4 0.00022 21.1 4.4 1.6 1 1 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFA82356.1 - 0.00017 21.2 3.4 0.0003 20.4 3.4 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EFA82356.1 - 0.0018 18.3 3.4 0.0061 16.6 3.4 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EFA82356.1 - 0.021 15.0 2.3 0.059 13.5 2.5 1.7 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 EFA82356.1 - 0.12 12.7 5.2 0.24 11.7 5.2 1.6 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EFA82356.1 - 0.71 10.0 6.6 1.6 8.9 6.6 1.6 1 0 0 1 1 1 0 RING-variant domain Hamartin PF04388.12 EFA82356.1 - 0.78 8.3 34.3 1.1 7.8 34.3 1.2 1 0 0 1 1 1 0 Hamartin protein zf-RING_11 PF17123.5 EFA82356.1 - 1.5 8.6 7.7 0.096 12.5 2.3 1.8 2 0 0 2 2 2 0 RING-like zinc finger DUF1284 PF06935.11 EFA82356.1 - 1.9 8.9 5.2 2.6 8.5 1.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) TFIIA PF03153.13 EFA82356.1 - 2.4 8.1 63.2 4.5 7.2 63.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit POPLD PF08170.12 EFA82357.1 - 6.6 7.2 7.3 36 4.8 7.3 2.4 1 0 0 1 1 1 0 POPLD (NUC188) domain Kinesin PF00225.23 EFA82358.1 - 1.7e-90 303.3 3.0 2.2e-90 303.0 3.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFA82358.1 - 4.1e-24 85.2 0.4 9.4e-20 71.1 0.0 2.4 1 1 0 2 2 2 2 Microtubule binding AdoHcyase_NAD PF00670.21 EFA82358.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TPK_B1_binding PF04265.14 EFA82359.1 - 0.012 15.3 1.0 0.012 15.3 1.0 2.5 3 0 0 3 3 3 0 Thiamin pyrophosphokinase, vitamin B1 binding domain CAGE1 PF15066.6 EFA82360.1 - 0.041 12.6 2.4 0.061 12.0 2.4 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family DUF2178 PF09946.9 EFA82360.1 - 0.29 11.3 2.1 0.29 11.3 0.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2178) Ras PF00071.22 EFA82361.1 - 7.8e-59 197.9 0.1 9e-59 197.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82361.1 - 9e-21 74.3 0.0 1.3e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82361.1 - 2.9e-09 36.6 0.0 3.5e-09 36.4 0.0 1.2 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA82361.1 - 2.1e-06 27.4 0.2 1.6e-05 24.6 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA82361.1 - 8.3e-05 22.6 0.0 0.00015 21.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA82361.1 - 0.00027 20.9 0.2 0.68 9.8 0.2 2.4 1 1 2 3 3 3 2 RsgA GTPase ATP_bind_1 PF03029.17 EFA82361.1 - 0.0063 16.3 0.9 0.066 13.0 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 EFA82361.1 - 0.017 14.4 0.1 0.047 13.0 0.0 1.7 2 0 0 2 2 2 0 Septin DnaJ PF00226.31 EFA82362.1 - 0.0001 22.4 1.6 0.0003 20.9 0.1 2.4 2 1 0 2 2 2 1 DnaJ domain Atg14 PF10186.9 EFA82362.1 - 0.031 13.4 17.3 0.032 13.3 17.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FNIP PF05725.12 EFA82363.1 - 3.4e-47 158.4 28.0 9.1e-12 45.0 0.0 7.2 6 1 0 6 6 6 6 FNIP Repeat LRR_1 PF00560.33 EFA82363.1 - 0.66 10.7 3.7 7.1 7.6 0.1 4.4 4 1 0 4 4 4 0 Leucine Rich Repeat PH_4 PF15404.6 EFA82364.1 - 0.12 12.2 2.6 0.13 12.1 1.0 1.9 1 1 1 2 2 2 0 Pleckstrin homology domain BRICHOS PF04089.14 EFA82364.1 - 0.16 12.2 2.7 0.25 11.6 0.7 1.9 2 0 0 2 2 2 0 BRICHOS domain DUF2572 PF10833.8 EFA82364.1 - 0.23 11.2 9.1 0.31 10.8 3.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2572) GSDH PF07995.11 EFA82367.1 - 0.0002 20.8 0.0 0.0012 18.3 0.0 2.1 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase NHL PF01436.21 EFA82367.1 - 0.16 12.1 1.7 0.5 10.5 0.1 2.8 3 0 0 3 3 3 0 NHL repeat Dicty_CTDC PF00526.18 EFA82368.1 - 4e-16 58.6 177.4 2.6e-07 30.4 10.5 15.1 14 1 0 14 14 14 8 Dictyostelium (slime mold) repeat PA14 PF07691.12 EFA82368.1 - 2.4e-10 40.4 0.1 4.9e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 PA14 domain Integrin_b_cyt PF08725.11 EFA82368.1 - 0.035 13.8 0.1 0.068 12.9 0.1 1.5 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain DUF5643 PF18705.1 EFA82368.1 - 0.12 12.3 1.3 0.55 10.2 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5643) SNARE_assoc PF09335.11 EFA82369.1 - 5.4e-28 97.9 3.9 5.4e-28 97.9 3.9 2.3 2 1 1 3 3 3 1 SNARE associated Golgi protein YrhC PF14143.6 EFA82369.1 - 0.005 16.9 4.9 0.072 13.2 0.2 3.5 3 0 0 3 3 3 1 YrhC-like protein Podoplanin PF05808.11 EFA82369.1 - 0.034 14.3 0.0 0.034 14.3 0.0 2.2 3 0 0 3 3 3 0 Podoplanin Protocadherin PF08374.11 EFA82369.1 - 0.045 13.7 1.6 0.045 13.7 0.2 1.7 2 0 0 2 2 2 0 Protocadherin DUF1772 PF08592.11 EFA82369.1 - 0.045 14.1 1.8 2.2 8.6 0.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) BPD_transp_1 PF00528.22 EFA82369.1 - 0.49 10.1 20.0 0.17 11.6 13.8 2.1 1 1 0 2 2 2 0 Binding-protein-dependent transport system inner membrane component Phage_holin_3_6 PF07332.11 EFA82369.1 - 0.52 10.4 17.3 0.088 12.9 5.9 3.1 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF996 PF06195.13 EFA82369.1 - 0.74 10.1 20.0 1 9.7 7.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF996) EphA2_TM PF14575.6 EFA82369.1 - 1.5 9.8 0.0 1.5 9.8 0.0 3.2 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain ATG16 PF08614.11 EFA82370.1 - 1.3e-46 159.4 23.6 1.7e-46 159.0 23.6 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) WD40 PF00400.32 EFA82370.1 - 2.3e-35 120.0 24.3 5.8e-08 33.3 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA82370.1 - 4.8e-13 49.2 2.2 0.029 14.7 0.0 5.5 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA82370.1 - 4e-05 23.1 7.8 0.00078 18.8 0.0 3.6 5 0 0 5 5 5 2 WD40-like domain KASH_CCD PF14662.6 EFA82370.1 - 0.0076 16.1 10.7 0.0076 16.1 10.7 3.1 1 1 2 3 3 3 1 Coiled-coil region of CCDC155 or KASH PALB2_WD40 PF16756.5 EFA82370.1 - 0.13 11.1 7.1 1 8.2 0.1 3.9 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain MscS_porin PF12795.7 EFA82370.1 - 0.73 9.3 19.6 0.44 10.0 17.6 1.5 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain PD40 PF07676.12 EFA82370.1 - 1.2 9.2 2.9 2.6 8.1 0.1 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF4407 PF14362.6 EFA82370.1 - 8.5 5.6 12.9 1.5e+02 1.5 12.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) SPA PF08616.10 EFA82373.1 - 8.9e-06 25.6 0.0 2.1e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EFA82373.1 - 0.041 14.4 0.0 0.041 14.4 0.0 2.9 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FtsJ PF01728.19 EFA82374.1 - 2.3e-63 213.5 0.0 2.9e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EFA82374.1 - 0.02 14.5 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_12 PF08242.12 EFA82374.1 - 0.1 13.4 5.3 7.3 7.4 3.4 2.5 2 1 0 2 2 2 0 Methyltransferase domain Nop25 PF09805.9 EFA82375.1 - 2.8e-12 47.3 55.5 1.6e-11 44.9 45.4 3.0 2 1 0 2 2 2 1 Nucleolar protein 12 (25kDa) DUF4611 PF15387.6 EFA82375.1 - 0.13 12.5 19.5 0.33 11.2 2.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PI3K_1B_p101 PF10486.9 EFA82375.1 - 0.14 9.9 17.0 0.16 9.7 17.0 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF3012 PF11216.8 EFA82375.1 - 0.37 10.9 0.1 0.37 10.9 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3012) CENP-B_dimeris PF09026.10 EFA82375.1 - 3.8 8.0 23.0 11 6.4 12.8 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain BING4CT PF08149.11 EFA82376.1 - 1.9e-13 50.0 0.1 3.3e-12 46.0 0.0 3.0 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.32 EFA82376.1 - 0.0016 19.2 0.0 0.077 13.9 0.0 2.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA82376.1 - 0.048 13.9 0.0 6.2 7.2 0.0 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain EpoR_lig-bind PF09067.10 EFA82377.1 - 0.053 13.7 7.9 0.087 13.0 7.9 1.4 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding RWP-RK PF02042.15 EFA82378.1 - 1.1e-24 86.2 0.1 1.9e-24 85.4 0.1 1.4 1 0 0 1 1 1 1 RWP-RK domain GREB1 PF15782.5 EFA82378.1 - 0.00044 17.6 23.1 0.00058 17.2 23.1 1.1 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer HTH_17 PF12728.7 EFA82378.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4665 PF15679.5 EFA82378.1 - 0.18 12.4 0.4 0.18 12.4 0.4 3.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4665) LAP1C PF05609.12 EFA82378.1 - 2.4 7.2 26.3 4.3 6.3 26.3 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 EFA82378.1 - 5 5.6 27.6 6.7 5.1 27.6 1.1 1 0 0 1 1 1 0 Macoilin family Plasmodium_Vir PF05795.11 EFA82378.1 - 7.4 5.9 14.2 1.2 8.5 10.3 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein R3H-assoc PF13902.6 EFA82379.1 - 6.4e-21 75.1 1.4 1e-20 74.5 1.4 1.3 1 0 0 1 1 1 1 R3H-associated N-terminal domain CTK3_C PF12350.8 EFA82379.1 - 0.1 12.7 0.4 3.5 7.9 0.1 2.6 3 0 0 3 3 3 0 CTD kinase subunit gamma CTK3 C-terminus Methyltransf_2 PF00891.18 EFA82380.1 - 1.7e-40 138.5 0.0 2.2e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA82380.1 - 1.5e-10 40.9 0.0 1.2e-09 38.0 0.0 2.3 2 1 1 3 3 3 1 Dimerisation domain Methyltransf_12 PF08242.12 EFA82380.1 - 0.011 16.4 0.2 0.1 13.3 0.2 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFA82380.1 - 0.038 14.0 0.0 0.097 12.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EFA82380.1 - 0.045 14.5 0.0 0.12 13.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EFA82380.1 - 0.094 12.3 0.1 0.31 10.6 0.1 1.9 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW FdhD-NarQ PF02634.15 EFA82381.1 - 0.16 11.6 0.2 0.22 11.2 0.2 1.1 1 0 0 1 1 1 0 FdhD/NarQ family HisKA_7TM PF16927.5 EFA82382.1 - 9.8e-05 22.5 4.2 0.00014 22.0 4.2 1.2 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase RICTOR_M PF14666.6 EFA82382.1 - 0.029 14.1 0.6 0.085 12.6 0.2 1.9 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain TIG PF01833.24 EFA82383.1 - 2.6e-09 37.1 44.4 7.9e-06 25.9 6.5 5.2 5 1 0 5 5 5 4 IPT/TIG domain CBM_X2 PF03442.14 EFA82383.1 - 6.1 7.0 7.8 24 5.1 0.4 3.8 3 1 0 3 3 3 0 Carbohydrate binding domain X2 zinc_ribbon_16 PF17034.5 EFA82384.1 - 1.3e-20 73.9 15.5 3e-20 72.7 15.5 1.7 1 0 0 1 1 1 1 Zinc-ribbon like family eIF2A PF08662.11 EFA82384.1 - 6.4e-06 26.2 0.3 0.64 9.9 0.0 3.9 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EFA82384.1 - 0.016 16.1 12.9 0.048 14.5 0.1 6.2 6 1 0 6 6 6 0 WD domain, G-beta repeat Dabb PF07876.12 EFA82385.1 - 9e-15 55.1 0.0 1.1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain SLAM PF06214.11 EFA82385.1 - 0.0043 17.1 0.4 0.0055 16.7 0.4 1.2 1 0 0 1 1 1 1 Signaling lymphocytic activation molecule (SLAM) protein Lep_receptor_Ig PF06328.11 EFA82385.1 - 0.025 14.5 1.1 5.3 7.1 0.0 2.2 1 1 1 2 2 2 0 Ig-like C2-type domain BUD22 PF09073.10 EFA82387.1 - 3.7 6.8 14.2 4.3 6.6 14.2 1.1 1 0 0 1 1 1 0 BUD22 TIG PF01833.24 EFA82389.1 - 0.00072 19.6 20.6 0.0069 16.4 2.9 3.3 4 1 0 4 4 4 2 IPT/TIG domain dCache_3 PF14827.6 EFA82389.1 - 0.024 14.3 0.2 0.041 13.5 0.2 1.3 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase DUF4397 PF14344.6 EFA82389.1 - 0.2 12.4 6.3 0.16 12.8 1.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4397) DUF5128 PF17170.4 EFA82390.1 - 0.00055 19.2 2.3 0.0041 16.3 1.8 2.0 1 1 1 2 2 2 2 6-bladed beta-propeller OLF PF02191.16 EFA82390.1 - 0.046 13.2 0.2 3.1 7.3 0.1 2.1 1 1 1 2 2 2 0 Olfactomedin-like domain TIG PF01833.24 EFA82390.1 - 0.35 11.0 10.0 1.4 9.0 1.3 3.1 2 2 0 2 2 2 0 IPT/TIG domain Inhibitor_I29 PF08246.12 EFA82391.1 - 7.9e-12 45.4 0.4 1.7e-11 44.4 0.4 1.6 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Podoplanin PF05808.11 EFA82391.1 - 0.025 14.7 0.1 0.053 13.6 0.1 1.5 1 0 0 1 1 1 0 Podoplanin Gmx_para_CXXCG PF09535.10 EFA82391.1 - 0.19 10.9 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) Peptidase_C1 PF00112.23 EFA82392.1 - 3.5e-47 161.3 6.1 5.9e-47 160.6 6.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease CAP PF00188.26 EFA82392.1 - 3.7e-05 24.6 1.6 3.7e-05 24.6 1.6 2.4 3 1 0 3 3 3 1 Cysteine-rich secretory protein family Peptidase_C1_2 PF03051.15 EFA82392.1 - 9e-05 21.4 0.7 0.15 10.8 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Peptidase_C39_2 PF13529.6 EFA82392.1 - 0.017 15.7 2.2 0.018 15.6 0.2 2.0 2 0 0 2 2 2 0 Peptidase_C39 like family Trypan_PARP PF05887.11 EFA82392.1 - 0.14 12.1 1.9 0.28 11.2 1.9 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ibs_toxin PF13956.6 EFA82392.1 - 0.78 9.8 3.2 1.5 8.9 3.2 1.5 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system AAA_16 PF13191.6 EFA82394.1 - 2.2e-06 28.2 0.0 5.7e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EFA82394.1 - 0.00018 21.8 0.0 0.00043 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA82394.1 - 0.00031 21.0 0.2 0.0041 17.4 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA82394.1 - 0.072 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFA82394.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2457 PF10446.9 EFA82396.1 - 0.0015 17.7 5.4 0.0015 17.7 5.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) FAM176 PF14851.6 EFA82396.1 - 0.012 15.3 4.7 0.026 14.2 4.7 1.6 1 1 0 1 1 1 0 FAM176 family PBP1_TM PF14812.6 EFA82396.1 - 0.017 15.5 15.2 0.017 15.5 15.2 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TRAP_alpha PF03896.16 EFA82396.1 - 0.03 13.5 0.8 0.035 13.3 0.8 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 EFA82396.1 - 0.46 9.7 14.2 0.55 9.5 14.2 1.1 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 EFA82396.1 - 0.66 9.3 7.8 0.69 9.3 7.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 EFA82396.1 - 1.8 6.8 11.8 2 6.6 11.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFA82396.1 - 4.2 5.4 12.6 4.7 5.3 12.6 1.0 1 0 0 1 1 1 0 Nop14-like family OAD_gamma PF04277.13 EFA82396.1 - 5.6 7.6 4.9 3.1 8.4 0.1 2.1 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain TIG PF01833.24 EFA82398.1 - 0.0039 17.2 1.5 0.0088 16.1 1.5 1.7 1 1 0 1 1 1 1 IPT/TIG domain Retrotrans_gag PF03732.17 EFA82400.1 - 4e-07 30.2 0.0 4.4e-06 26.9 0.0 2.5 2 0 0 2 2 2 1 Retrotransposon gag protein MJ1316 PF04457.12 EFA82401.1 - 9.1e-09 35.9 0.8 3.5e-08 34.1 0.1 2.4 3 1 0 3 3 3 1 MJ1316 RNA cyclic group end recognition domain Drf_GBD PF06371.13 EFA82401.1 - 2.5 7.6 11.1 1.3 8.6 8.7 1.7 1 1 1 2 2 2 0 Diaphanous GTPase-binding Domain TFIIA PF03153.13 EFA82401.1 - 2.8 7.8 20.8 3.9 7.4 20.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Claudin_2 PF13903.6 EFA82402.1 - 0.053 13.3 0.2 0.09 12.5 0.2 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction GP41 PF00517.17 EFA82402.1 - 0.11 12.4 2.4 0.17 11.7 1.9 1.4 1 1 0 1 1 1 0 Retroviral envelope protein RseC_MucC PF04246.12 EFA82402.1 - 0.19 11.7 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC TIG PF01833.24 EFA82403.1 - 0.00046 20.2 5.1 0.00046 20.2 5.1 2.7 2 0 0 2 2 2 1 IPT/TIG domain EB PF01683.18 EFA82403.1 - 0.057 13.7 7.4 0.14 12.4 6.1 2.2 2 0 0 2 2 2 0 EB module LapA_dom PF06305.11 EFA82403.1 - 0.16 11.8 0.5 0.42 10.4 0.5 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EGF_2 PF07974.13 EFA82403.1 - 0.44 11.0 17.3 1.4 9.3 17.3 1.9 1 0 0 1 1 1 0 EGF-like domain TAF4 PF05236.14 EFA82404.1 - 1.1e-33 117.3 7.6 1.1e-33 117.3 7.6 6.7 5 1 2 7 7 7 1 Transcription initiation factor TFIID component TAF4 family Pkinase PF00069.25 EFA82405.1 - 1.4e-78 263.9 0.0 2.8e-78 262.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82405.1 - 1.3e-31 109.8 0.0 2.7e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EFA82405.1 - 4.2e-12 46.2 9.7 2.3e-10 40.7 7.9 2.9 2 1 0 2 2 2 1 FHA domain Kinase-like PF14531.6 EFA82405.1 - 3.6e-09 36.3 0.0 3.1e-08 33.3 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Yop-YscD_cpl PF16697.5 EFA82405.1 - 6.1e-05 23.3 0.5 0.00025 21.3 0.2 2.2 2 1 1 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 EFA82405.1 - 0.00054 19.4 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Nucleo_P87 PF07267.11 EFA82405.1 - 1.5 7.6 16.2 2.5 6.9 16.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 BAT2_N PF07001.11 EFA82405.1 - 2.5 8.5 0.0 2.5 8.5 0.0 3.8 3 1 0 3 3 3 0 BAT2 N-terminus ADH_N PF08240.12 EFA82406.1 - 1.2e-26 92.7 7.2 1.2e-26 92.7 7.2 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFA82406.1 - 5.8e-16 58.7 0.0 8.9e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA82406.1 - 0.00083 20.4 0.0 0.0051 17.9 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Oxidored_nitro PF00148.19 EFA82406.1 - 0.04 12.6 0.0 0.058 12.1 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase AlaDh_PNT_C PF01262.21 EFA82406.1 - 0.043 13.1 0.2 0.079 12.2 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 EFA82406.1 - 0.049 13.4 0.1 0.07 12.8 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 EFA82406.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain VMA21 PF09446.10 EFA82407.1 - 1.3e-16 60.4 3.5 1.9e-16 59.9 3.5 1.3 1 0 0 1 1 1 1 VMA21-like domain CCDC-167 PF15188.6 EFA82407.1 - 9.1e-05 22.7 2.4 0.00011 22.5 1.0 1.8 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 167 DHHC PF01529.20 EFA82407.1 - 0.018 15.2 1.3 0.031 14.4 1.3 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase LAGLIDADG_2 PF03161.13 EFA82407.1 - 0.065 13.3 2.2 0.094 12.7 1.5 1.6 1 1 0 1 1 1 0 LAGLIDADG DNA endonuclease family KIAA1430 PF13879.6 EFA82407.1 - 0.092 13.5 15.7 0.14 13.0 15.7 1.3 1 0 0 1 1 1 0 KIAA1430 homologue SLC12 PF03522.15 EFA82407.1 - 0.15 11.1 10.2 0.16 11.0 10.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF334 PF03904.13 EFA82407.1 - 0.17 11.4 10.2 0.22 11.0 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF334) FCP1_C PF09309.10 EFA82407.1 - 0.91 9.3 12.8 1.1 9.0 12.8 1.1 1 0 0 1 1 1 0 FCP1, C-terminal Neur_chan_memb PF02932.16 EFA82407.1 - 1.9 8.5 5.8 2.6 8.0 5.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 EFA82407.1 - 7.2 5.9 11.7 0.15 11.4 5.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 EFA82407.1 - 9.6 6.1 12.8 15 5.5 12.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SUIM_assoc PF16619.5 EFA82408.1 - 0.0015 18.5 1.0 0.004 17.2 0.1 2.2 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF3958 PF13125.6 EFA82408.1 - 0.012 15.9 1.0 0.012 15.9 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) YtxH PF12732.7 EFA82408.1 - 0.064 13.8 2.0 0.28 11.8 2.0 2.1 1 1 1 2 2 2 0 YtxH-like protein Glt_symporter PF03616.14 EFA82408.1 - 0.24 10.0 0.0 0.41 9.3 0.0 1.3 1 0 0 1 1 1 0 Sodium/glutamate symporter AI-2E_transport PF01594.16 EFA82410.1 - 3.1 6.9 5.8 12 5.0 0.6 2.4 2 0 0 2 2 2 0 AI-2E family transporter ABC2_membrane PF01061.24 EFA82411.1 - 1.5e-34 119.3 23.2 1.5e-34 119.3 23.2 2.0 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 EFA82411.1 - 8.9e-26 91.0 0.1 1.9e-25 90.0 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 EFA82411.1 - 6.5e-10 39.3 0.3 7.4e-06 26.0 0.4 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA82411.1 - 4.6e-05 23.0 0.0 0.0035 16.8 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EFA82411.1 - 0.00071 18.8 21.3 0.00071 18.8 21.3 2.8 2 1 0 3 3 3 1 ABC-2 family transporter protein AAA_18 PF13238.6 EFA82411.1 - 0.00087 19.8 0.2 0.0052 17.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFA82411.1 - 0.001 19.0 0.0 0.0024 17.8 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFA82411.1 - 0.0029 17.3 0.2 0.0078 15.9 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA82411.1 - 0.0084 16.4 0.0 0.026 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA82411.1 - 0.036 14.5 0.0 0.061 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EFA82411.1 - 0.059 12.5 0.1 0.099 11.8 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 EFA82411.1 - 0.069 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EFA82411.1 - 0.074 12.8 0.2 0.49 10.1 0.1 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family P53_C PF11619.8 EFA82411.1 - 0.083 13.0 0.1 0.47 10.5 0.0 2.1 2 0 0 2 2 2 0 Transcription factor P53 - C terminal domain AAA_23 PF13476.6 EFA82411.1 - 0.1 13.1 1.2 0.22 12.0 0.1 1.9 2 0 0 2 2 2 0 AAA domain DUF2070 PF09843.9 EFA82411.1 - 0.12 10.6 15.9 0.18 10.0 15.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) cobW PF02492.19 EFA82411.1 - 0.13 11.9 0.1 0.24 11.0 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EFA82411.1 - 0.13 11.3 0.1 0.25 10.3 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 EFA82411.1 - 0.18 12.0 0.2 0.31 11.3 0.2 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFA82411.1 - 1.8 8.3 5.2 2.4 7.9 0.1 3.0 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Pkinase_Tyr PF07714.17 EFA82412.1 - 3.4e-48 164.2 0.0 2.8e-46 157.9 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA82412.1 - 3.4e-42 144.6 0.0 8.3e-39 133.5 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain COR PF16095.5 EFA82412.1 - 6.6e-31 107.6 3.0 1.2e-22 80.6 0.1 3.1 3 0 0 3 3 3 2 C-terminal of Roc, COR, domain DEP PF00610.21 EFA82412.1 - 7.4e-31 106.0 1.6 8.8e-18 64.1 1.6 2.9 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Roc PF08477.13 EFA82412.1 - 1.3e-12 48.0 2.0 1.6e-07 31.5 0.0 3.1 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 EFA82412.1 - 6.2e-10 38.7 22.2 1.2e-06 28.1 6.2 3.8 2 1 1 3 3 3 2 Leucine rich repeat Ras PF00071.22 EFA82412.1 - 0.0002 21.0 0.3 0.47 10.0 0.0 2.5 2 0 0 2 2 2 2 Ras family LRR_1 PF00560.33 EFA82412.1 - 4.9 8.1 18.8 1.5 9.6 3.2 6.5 5 1 0 5 5 5 0 Leucine Rich Repeat WD40 PF00400.32 EFA82413.1 - 2.3e-14 53.5 1.7 0.0016 19.2 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA82413.1 - 2.7e-06 27.6 0.2 0.13 12.6 0.0 4.2 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA82413.1 - 0.00042 19.4 0.3 0.05 12.5 0.1 2.8 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein MecA PF05389.12 EFA82413.1 - 0.11 12.1 3.1 0.21 11.2 3.1 1.4 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) CobT PF06213.12 EFA82413.1 - 0.35 10.2 7.1 0.52 9.6 7.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NICE-3 PF07406.11 EFA82414.1 - 5.9e-05 23.1 0.1 0.00013 22.0 0.1 1.6 1 0 0 1 1 1 1 NICE-3 protein ECSCR PF15820.5 EFA82414.1 - 0.011 15.6 0.3 0.34 10.8 0.2 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator N1221 PF07923.13 EFA82414.1 - 0.017 14.4 0.1 0.031 13.5 0.1 1.4 1 0 0 1 1 1 0 N1221-like protein DUF4129 PF13559.6 EFA82414.1 - 0.16 12.2 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Pex24p PF06398.11 EFA82414.1 - 0.17 10.9 5.3 0.26 10.2 3.3 2.0 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Y_phosphatase PF00102.27 EFA82415.1 - 2.8e-05 23.8 2.0 7.7e-05 22.4 0.0 2.5 3 0 0 3 3 3 1 Protein-tyrosine phosphatase PH PF00169.29 EFA82415.1 - 3.7e-05 24.2 0.6 7.5e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 PH domain Y_phosphatase3 PF13350.6 EFA82415.1 - 0.0004 20.4 0.0 0.00099 19.1 0.0 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EFA82415.1 - 0.0005 19.9 0.0 0.0005 19.9 0.0 2.9 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFA82415.1 - 0.015 15.5 0.1 0.056 13.6 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate CDKN3 PF05706.12 EFA82415.1 - 0.043 13.5 0.1 0.079 12.6 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PH_2 PF08458.10 EFA82415.1 - 0.1 13.0 0.1 0.27 11.6 0.1 1.7 1 0 0 1 1 1 0 Plant pleckstrin homology-like region APG5 PF04106.12 EFA82416.1 - 2.4e-57 194.2 3.5 3.1e-57 193.8 3.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 Orf78 PF06024.12 EFA82416.1 - 0.66 10.3 8.2 0.78 10.1 6.2 2.1 2 0 0 2 2 2 0 Orf78 (ac78) tRNA-synt_1d PF00750.19 EFA82417.1 - 1.4e-70 237.9 0.0 1.8e-68 231.0 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFA82417.1 - 9.2e-20 71.0 0.0 2e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFA82417.1 - 0.019 15.6 0.4 0.3 11.7 0.1 2.9 3 0 0 3 3 3 0 Arginyl tRNA synthetase N terminal domain DHHC PF01529.20 EFA82418.1 - 5.3e-35 120.4 5.9 5.3e-35 120.4 5.9 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase Solute_trans_a PF03619.16 EFA82418.1 - 0.0012 18.4 4.3 0.005 16.4 4.4 1.8 1 1 0 1 1 1 1 Organic solute transporter Ostalpha Pex24p PF06398.11 EFA82418.1 - 0.47 9.4 8.6 0.12 11.3 0.9 2.8 2 1 1 3 3 3 0 Integral peroxisomal membrane peroxin Kelch_6 PF13964.6 EFA82420.1 - 2.4e-15 56.2 0.8 4.7e-08 33.0 0.1 3.8 2 1 1 3 3 3 2 Kelch motif zf-B_box PF00643.24 EFA82420.1 - 0.025 14.7 9.6 0.059 13.5 9.6 1.6 1 0 0 1 1 1 0 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82420.1 - 0.029 14.7 0.1 0.12 12.8 0.1 2.1 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region Kelch_1 PF01344.25 EFA82420.1 - 0.064 12.9 0.0 0.33 10.6 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 EFA82420.1 - 0.12 12.4 0.4 2.3 8.3 0.1 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain PQQ PF01011.21 EFA82420.1 - 0.13 12.2 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat Kelch_5 PF13854.6 EFA82420.1 - 0.15 12.1 1.4 0.52 10.4 0.4 2.4 2 0 0 2 2 2 0 Kelch motif Mit_KHE1 PF10173.9 EFA82420.1 - 0.18 11.9 4.8 0.39 10.8 4.8 1.5 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Med9 PF07544.13 EFA82420.1 - 0.45 10.6 6.8 0.47 10.6 1.7 2.7 1 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UPF0449 PF15136.6 EFA82420.1 - 8.9 6.9 7.5 1.4 9.4 2.5 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DDE_Tnp_4 PF13359.6 EFA82421.1 - 1.2e-09 38.1 0.0 1.6e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease TIG PF01833.24 EFA82422.1 - 4.4e-14 52.3 19.8 5.4e-05 23.2 0.5 4.4 3 1 1 4 4 4 4 IPT/TIG domain KH_5 PF13184.6 EFA82424.1 - 0.02 15.0 0.0 0.032 14.3 0.0 1.4 1 1 0 1 1 1 0 NusA-like KH domain Ydr279_N PF17745.1 EFA82425.1 - 0.06 13.6 0.0 0.089 13.1 0.0 1.2 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain DAP3 PF10236.9 EFA82426.1 - 0.022 14.0 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_10 PF12846.7 EFA82426.1 - 0.064 12.2 0.0 0.16 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 EFA82426.1 - 0.16 12.3 0.0 4.4 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain FtsJ PF01728.19 EFA82427.1 - 2e-09 37.8 0.0 5e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase TIG PF01833.24 EFA82427.1 - 0.0085 16.2 6.5 0.0085 16.2 6.5 3.0 2 0 0 2 2 2 1 IPT/TIG domain Orf78 PF06024.12 EFA82427.1 - 1.1 9.6 9.7 0.41 11.0 3.5 2.7 2 0 0 2 2 2 0 Orf78 (ac78) CLU PF13236.6 EFA82428.1 - 1e-35 123.6 0.0 1e-35 123.6 0.0 2.8 2 0 0 2 2 2 1 Clustered mitochondria SRPRB PF09439.10 EFA82428.1 - 6.5e-32 110.4 0.0 3.9e-31 107.9 0.0 2.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit UQ_con PF00179.26 EFA82428.1 - 2.4e-26 92.1 0.0 8.1e-26 90.3 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Arf PF00025.21 EFA82428.1 - 2.1e-15 56.6 0.0 7.6e-15 54.8 0.0 2.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA82428.1 - 5.9e-05 23.3 0.0 0.00036 20.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase zf_CCCH_4 PF18345.1 EFA82428.1 - 0.00041 20.3 6.0 0.0014 18.6 6.0 2.0 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 EFA82428.1 - 0.0023 18.6 5.4 0.0023 18.6 5.4 3.6 2 1 1 3 3 3 1 Torus domain zf-CCCH PF00642.24 EFA82428.1 - 0.017 15.0 3.5 0.051 13.5 3.5 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFA82428.1 - 0.036 13.9 4.5 0.085 12.7 4.5 1.7 1 0 0 1 1 1 0 CCCH-type zinc finger AAA_12 PF13087.6 EFA82429.1 - 2.6e-56 190.4 0.1 1e-55 188.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFA82429.1 - 3.9e-39 135.0 2.5 1.8e-22 80.4 0.3 4.1 3 1 1 4 4 4 2 AAA domain AAA_19 PF13245.6 EFA82429.1 - 2.9e-11 43.9 0.3 8.9e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA82429.1 - 1.5e-08 34.6 0.0 1.2e-07 31.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain SUIM_assoc PF16619.5 EFA82429.1 - 6.5e-05 22.9 4.0 8.3 6.6 0.0 3.6 3 2 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 DUF2075 PF09848.9 EFA82429.1 - 0.0022 17.3 0.0 0.0022 17.3 0.0 4.1 4 1 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EFA82429.1 - 0.0055 17.0 0.2 0.028 14.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA82429.1 - 0.082 13.5 0.1 0.36 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFA82429.1 - 0.13 11.7 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TPR_17 PF13431.6 EFA82432.1 - 8.3e-87 279.5 20.9 1.5e-12 46.9 0.0 8.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA82432.1 - 7.7e-15 54.3 30.0 0.048 13.4 0.3 8.2 8 0 0 8 8 8 7 TPR repeat Anth_Ig PF05587.13 EFA82432.1 - 9.2e-08 32.3 6.8 8.6 6.7 0.0 7.0 7 0 0 7 7 7 3 Anthrax receptor extracellular domain DUF2155 PF09923.9 EFA82432.1 - 0.00068 19.8 1.0 51 4.2 0.0 5.4 3 1 3 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2155) DUF1153 PF06627.11 EFA82432.1 - 0.0048 17.0 0.4 30 4.9 0.0 6.4 10 0 0 10 10 10 0 Protein of unknown function (DUF1153) Ntox46 PF15538.6 EFA82432.1 - 0.0077 16.2 0.8 6.4 6.7 0.0 3.7 1 1 3 4 4 4 1 Bacterial toxin 46 TPR_2 PF07719.17 EFA82432.1 - 0.022 14.9 16.5 73 3.9 0.1 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat Glyoxalase_2 PF12681.7 EFA82432.1 - 0.13 12.2 0.3 2.7 8.0 0.0 3.0 4 0 0 4 4 4 0 Glyoxalase-like domain NleF_casp_inhib PF16809.5 EFA82432.1 - 0.14 12.1 8.2 47 3.9 0.1 6.2 3 3 3 6 6 6 0 NleF caspase inhibitor TPR_1 PF00515.28 EFA82432.1 - 1.8 8.5 28.9 97 3.0 0.1 10.3 11 0 0 11 11 11 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 EFA82433.1 - 1.7e-62 211.1 0.0 2.2e-62 210.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA82433.1 - 5.7e-54 183.2 0.0 1e-53 182.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFA82433.1 - 3e-05 23.0 0.8 5.5e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFA82433.1 - 0.00091 18.3 0.2 0.00091 18.3 0.2 2.9 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFA82433.1 - 0.0016 18.5 0.4 0.0027 17.6 0.4 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFA82433.1 - 0.0069 16.0 0.0 1.4 8.5 0.0 2.5 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Filamin PF00630.19 EFA82434.1 - 0.0015 19.4 0.0 0.0016 19.3 0.0 1.1 1 0 0 1 1 1 1 Filamin/ABP280 repeat Y_Y_Y PF07495.13 EFA82434.1 - 0.059 13.3 0.0 0.068 13.1 0.0 1.1 1 0 0 1 1 1 0 Y_Y_Y domain DUF3244 PF11589.8 EFA82434.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) DUF3713 PF12506.8 EFA82435.1 - 0.021 15.1 0.0 0.024 15.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) Atx10homo_assoc PF09759.9 EFA82436.1 - 1.5e-17 63.4 0.1 1.8e-17 63.2 0.1 1.1 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Atx10homo_assoc PF09759.9 EFA82437.1 - 0.012 15.6 0.1 0.012 15.6 0.1 5.0 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain DUF3430 PF11912.8 EFA82438.1 - 1.8e-29 103.3 22.9 2.3e-29 103.0 22.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) Kelch_6 PF13964.6 EFA82439.1 - 4.8e-06 26.7 2.0 0.081 13.3 0.1 4.9 5 1 0 5 5 5 2 Kelch motif OLF PF02191.16 EFA82439.1 - 0.012 15.2 1.6 0.13 11.8 1.6 2.1 1 1 0 1 1 1 0 Olfactomedin-like domain zf-B_box PF00643.24 EFA82440.1 - 0.005 17.0 9.9 0.013 15.6 9.9 1.6 1 0 0 1 1 1 1 B-box zinc finger zf-UBP PF02148.19 EFA82440.1 - 1.1 9.6 8.0 1.1 9.6 4.9 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein UPF0449 PF15136.6 EFA82440.1 - 1.2 9.6 12.8 0.34 11.4 2.9 2.7 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF3958 PF13125.6 EFA82440.1 - 1.9 8.7 12.3 0.14 12.4 6.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3958) Phosducin PF02114.16 EFA82441.1 - 2.6e-23 82.3 3.7 4.1e-20 71.8 4.0 2.2 1 1 1 2 2 2 2 Phosducin EF-1_beta_acid PF10587.9 EFA82441.1 - 0.0032 17.9 8.8 0.0032 17.9 8.8 3.2 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Glyco_hydro_47 PF01532.20 EFA82442.1 - 5.7e-143 477.1 0.0 6.7e-143 476.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 EFA82442.1 - 0.0032 16.8 0.9 1.3 8.1 0.0 3.1 3 1 0 3 3 3 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_76 PF03663.14 EFA82442.1 - 0.0068 16.0 1.3 4.1 6.8 0.0 3.6 2 1 0 3 3 3 1 Glycosyl hydrolase family 76 XAP5 PF04921.14 EFA82443.1 - 2e-82 276.8 16.5 2e-82 276.8 16.5 2.3 1 1 1 2 2 2 1 XAP5, circadian clock regulator Macoilin PF09726.9 EFA82443.1 - 5 5.6 24.4 6.3 5.2 24.4 1.1 1 0 0 1 1 1 0 Macoilin family N6-adenineMlase PF10237.9 EFA82444.1 - 9.2e-45 152.3 1.7 1.1e-44 152.0 1.7 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 EFA82444.1 - 0.0092 15.6 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DUF43 PF01861.16 EFA82444.1 - 0.033 13.4 0.0 0.049 12.8 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Cofilin_ADF PF00241.20 EFA82445.1 - 9.6e-22 77.0 0.1 1.2e-21 76.8 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein zf-B_box PF00643.24 EFA82446.1 - 0.0075 16.4 12.1 0.02 15.0 12.1 1.7 1 0 0 1 1 1 1 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82446.1 - 0.022 15.2 2.3 0.028 14.8 0.1 2.3 3 0 0 3 3 3 0 LOR/SDH bifunctional enzyme conserved region SlyX PF04102.12 EFA82446.1 - 2.9 8.6 8.8 0.42 11.3 2.5 2.9 2 1 1 3 3 3 0 SlyX Fzo_mitofusin PF04799.13 EFA82446.1 - 4.5 6.8 10.0 0.96 9.0 0.9 3.0 2 1 1 3 3 3 0 fzo-like conserved region Piezo_RRas_bdg PF12166.8 EFA82447.1 - 3.6e-100 336.2 2.1 3.6e-100 336.2 2.1 5.3 6 0 0 6 6 3 1 Piezo non-specific cation channel, R-Ras-binding domain Ras PF00071.22 EFA82447.1 - 1.4e-31 109.3 0.0 4.2e-31 107.7 0.0 1.9 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82447.1 - 5.9e-20 71.7 1.1 1.6e-19 70.3 0.0 2.5 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase CH PF00307.31 EFA82447.1 - 1.2e-15 57.6 0.0 1.2e-14 54.4 0.0 2.7 2 0 0 2 2 2 1 Calponin homology (CH) domain Arf PF00025.21 EFA82447.1 - 4.3e-14 52.4 0.0 1.2e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 ADP-ribosylation factor family SUIM_assoc PF16619.5 EFA82447.1 - 2.9e-09 36.9 10.4 2.7e-05 24.1 0.0 6.2 4 1 1 5 5 5 2 Unstructured region C-term to UIM in Ataxin3 MMR_HSR1 PF01926.23 EFA82447.1 - 6.7e-05 22.9 0.3 0.00058 19.9 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA82447.1 - 0.0096 15.4 0.0 0.036 13.5 0.0 2.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DZR PF12773.7 EFA82447.1 - 0.087 12.9 0.3 0.21 11.6 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EFA82447.1 - 0.16 11.8 3.1 0.38 10.5 3.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain CCAP PF11105.8 EFA82447.1 - 0.44 10.5 2.6 1.6 8.7 2.6 2.0 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a GTA_holin_3TM PF11351.8 EFA82447.1 - 2.4 8.7 4.8 12 6.5 4.8 2.2 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release zf-AN1 PF01428.16 EFA82448.1 - 8.6e-13 48.2 21.0 3.2e-11 43.2 8.6 3.1 3 0 0 3 3 3 2 AN1-like Zinc finger UBX PF00789.20 EFA82448.1 - 7.4e-11 42.1 0.1 1.7e-10 41.0 0.1 1.6 1 0 0 1 1 1 1 UBX domain Transp_Tc5_C PF04236.15 EFA82448.1 - 0.013 15.9 5.5 0.013 15.9 5.5 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain XAP5 PF04921.14 EFA82448.1 - 0.049 13.4 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator IBR PF01485.21 EFA82448.1 - 7.5 6.9 14.8 6.4 7.1 12.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-B_box PF00643.24 EFA82449.1 - 0.00034 20.7 8.8 0.00096 19.3 8.8 1.7 1 0 0 1 1 1 1 B-box zinc finger Cep57_CLD PF14073.6 EFA82449.1 - 0.36 10.8 8.0 0.032 14.3 2.5 2.0 2 1 0 2 2 2 0 Centrosome localisation domain of Cep57 DUF3958 PF13125.6 EFA82449.1 - 0.68 10.2 10.4 0.11 12.8 4.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3958) Med9 PF07544.13 EFA82449.1 - 1 9.5 8.3 0.12 12.5 1.8 2.7 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 UPF0449 PF15136.6 EFA82449.1 - 2.5 8.6 10.1 0.34 11.4 2.5 2.6 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 zf-UBP PF02148.19 EFA82449.1 - 2.6 8.4 8.5 4.4 7.7 5.3 2.4 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Kelch_6 PF13964.6 EFA82450.1 - 0.00012 22.3 0.3 0.01 16.1 0.0 3.4 4 0 0 4 4 4 1 Kelch motif OLF PF02191.16 EFA82450.1 - 0.019 14.5 0.3 0.071 12.6 0.3 2.0 1 1 0 1 1 1 0 Olfactomedin-like domain FAM72 PF14976.6 EFA82450.1 - 0.04 14.1 0.3 1.6 8.9 0.0 2.2 1 1 1 2 2 2 0 FAM72 protein CBM_14 PF01607.24 EFA82451.1 - 9.3e-08 32.1 8.7 9.3e-08 32.1 8.7 1.9 1 1 1 2 2 2 1 Chitin binding Peritrophin-A domain Glucosamine_iso PF01182.20 EFA82452.1 - 4.1e-20 72.6 0.0 5.5e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF2985 PF11204.8 EFA82453.1 - 0.063 13.4 0.8 0.063 13.4 0.8 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2985) Actin PF00022.19 EFA82454.1 - 7.1e-124 413.5 0.0 1.8e-123 412.2 0.0 1.6 1 1 0 1 1 1 1 Actin Ist1 PF03398.14 EFA82454.1 - 3e-42 144.3 1.4 4.4e-42 143.8 1.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Filamin PF00630.19 EFA82454.1 - 2.8e-39 134.1 0.9 2.3e-20 73.3 0.1 2.7 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 EFA82454.1 - 2.1e-07 31.1 8.5 0.00022 21.5 1.1 3.2 3 1 1 4 4 4 2 Invasin, domain 3 VDE PF07137.11 EFA82458.1 - 0.2 11.1 0.2 0.31 10.5 0.2 1.3 1 0 0 1 1 1 0 VDE lipocalin domain Meth_synt_2 PF01717.18 EFA82459.1 - 1.7e-152 507.3 0.0 5.5e-142 472.8 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EFA82459.1 - 8.5e-107 357.3 0.4 2.9e-100 335.8 0.1 3.8 3 1 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain Thioredoxin_6 PF13848.6 EFA82459.1 - 0.028 14.4 1.4 6.9 6.5 0.0 3.3 4 0 0 4 4 4 0 Thioredoxin-like domain Integrase_H2C2 PF17921.1 EFA82460.1 - 0.0072 16.4 1.4 0.014 15.5 1.4 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Kelch_6 PF13964.6 EFA82461.1 - 0.0012 19.0 0.1 0.01 16.1 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Saccharop_dh_N PF04455.12 EFA82461.1 - 0.0077 16.6 0.4 0.026 14.9 0.4 1.9 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region zf-B_box PF00643.24 EFA82461.1 - 2 8.6 15.6 5.4 7.3 15.6 1.8 1 0 0 1 1 1 0 B-box zinc finger FNIP PF05725.12 EFA82462.1 - 7.4e-18 64.4 5.6 3.6e-06 27.1 0.1 5.3 1 1 4 6 6 6 5 FNIP Repeat BTB_3 PF16017.5 EFA82462.1 - 0.12 12.4 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 BTB/POZ domain Coiled PF05710.12 EFA82463.1 - 0.061 14.2 1.6 0.067 14.0 1.6 1.3 1 1 0 1 1 1 0 Coiled coil WD40 PF00400.32 EFA82464.1 - 1.4e-26 92.2 15.3 2e-07 31.6 0.3 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA82464.1 - 3.1e-17 62.6 4.0 7.6e-06 26.1 0.0 5.3 5 1 0 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA82464.1 - 4e-08 32.6 2.4 0.0018 17.3 0.3 2.9 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein OSCP PF00213.18 EFA82464.1 - 0.00014 22.0 0.1 0.016 15.3 0.0 2.6 1 1 1 2 2 2 1 ATP synthase delta (OSCP) subunit Nsp1_C PF05064.13 EFA82464.1 - 0.017 15.0 3.0 0.051 13.4 3.0 1.8 1 0 0 1 1 1 0 Nsp1-like C-terminal region ssDBP_DBD PF18361.1 EFA82464.1 - 0.11 12.6 0.3 0.49 10.5 0.0 2.1 2 0 0 2 2 2 0 Single stranded DNA-binding protein ss DNA binding domain FlaC_arch PF05377.11 EFA82464.1 - 0.33 11.4 5.8 0.12 12.8 2.0 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 EFA82464.1 - 0.66 9.8 4.0 1.5 8.7 4.0 1.5 1 0 0 1 1 1 0 Septum formation initiator Striatin PF08232.12 EFA82464.1 - 8.4 7.0 15.6 17 6.0 13.8 2.2 1 1 1 2 2 2 0 Striatin family AAA_16 PF13191.6 EFA82465.1 - 3.2e-07 30.9 0.0 8.1e-07 29.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EFA82465.1 - 0.00013 22.3 0.0 0.00026 21.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Meth_synt_1 PF08267.12 EFA82465.1 - 0.00056 19.5 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 Cobalamin-independent synthase, N-terminal domain AAA_22 PF13401.6 EFA82465.1 - 0.00097 19.4 0.1 0.0099 16.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EFA82465.1 - 0.075 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_30 PF13604.6 EFA82465.1 - 0.085 12.6 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain zf-LSD1 PF06943.12 EFA82466.1 - 0.0075 16.1 6.0 0.79 9.6 0.2 3.1 3 0 0 3 3 3 2 LSD1 zinc finger SAM_PNT PF02198.16 EFA82467.1 - 0.0017 18.3 2.7 1.1 9.2 0.0 2.9 2 1 1 3 3 3 2 Sterile alpha motif (SAM)/Pointed domain Retrotrans_gag PF03732.17 EFA82468.1 - 3.8e-07 30.3 0.0 9e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein Kelch_6 PF13964.6 EFA82469.1 - 1.7e-14 53.5 5.8 1.6e-09 37.7 0.2 4.5 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA82469.1 - 0.011 15.8 11.1 0.026 14.7 11.1 1.6 1 0 0 1 1 1 0 B-box zinc finger Kelch_1 PF01344.25 EFA82469.1 - 0.02 14.5 0.0 0.067 12.8 0.0 2.0 1 0 0 1 1 1 0 Kelch motif FAD-SLDH PF12318.8 EFA82469.1 - 0.15 12.1 0.3 0.29 11.2 0.3 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase PsaD PF02531.16 EFA82470.1 - 0.081 12.5 0.2 0.2 11.2 0.2 1.6 1 0 0 1 1 1 0 PsaD TIG PF01833.24 EFA82472.1 - 3.2e-07 30.3 41.0 0.00017 21.6 2.8 5.4 4 1 0 5 5 5 3 IPT/TIG domain CTXphi_pIII-N1 PF16710.5 EFA82472.1 - 0.22 11.7 1.5 3.1 8.0 0.1 2.5 2 0 0 2 2 2 0 N-terminal N1 domain of Vibrio phage CTXphi pIII DUF1533 PF07550.11 EFA82472.1 - 0.41 10.6 13.2 2.3 8.2 2.9 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1533) CBM_X2 PF03442.14 EFA82472.1 - 6.8 6.9 13.7 6 7.1 0.0 4.7 5 1 0 5 5 5 0 Carbohydrate binding domain X2 Kelch_6 PF13964.6 EFA82473.1 - 2.2e-07 30.9 3.0 0.00027 21.1 0.1 4.6 5 1 0 5 5 5 1 Kelch motif NHL PF01436.21 EFA82473.1 - 0.0072 16.3 0.3 0.38 10.9 0.0 2.4 2 0 0 2 2 2 1 NHL repeat OLF PF02191.16 EFA82473.1 - 0.011 15.3 7.2 0.058 12.9 1.9 2.1 1 1 1 2 2 2 0 Olfactomedin-like domain DUF3470 PF11953.8 EFA82474.1 - 0.093 12.7 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3470) Interferon PF00143.19 EFA82474.1 - 2.4 8.3 13.5 0.083 13.1 5.9 2.3 2 2 0 2 2 2 0 Interferon alpha/beta domain SPP PF06550.11 EFA82475.1 - 0.061 12.8 0.6 0.088 12.3 0.6 1.2 1 0 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease Xpo1 PF08389.12 EFA82475.1 - 0.44 10.6 3.9 2.1 8.4 0.6 2.7 2 1 0 2 2 2 0 Exportin 1-like protein Kelch_6 PF13964.6 EFA82476.1 - 9.1e-14 51.2 6.4 2.3e-07 30.8 0.1 4.7 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA82476.1 - 0.00019 21.5 7.8 0.00042 20.4 7.8 1.5 1 0 0 1 1 1 1 B-box zinc finger Saccharop_dh_N PF04455.12 EFA82476.1 - 0.0071 16.7 0.4 0.026 14.9 0.4 2.0 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Kelch_6 PF13964.6 EFA82478.1 - 6.3e-06 26.3 3.6 0.015 15.6 0.0 4.9 5 1 0 5 5 5 1 Kelch motif DUF1419 PF07215.11 EFA82478.1 - 0.0036 17.4 0.5 0.78 9.9 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1419) OLF PF02191.16 EFA82478.1 - 0.023 14.2 4.5 0.025 14.1 0.3 2.2 1 1 1 2 2 2 0 Olfactomedin-like domain NHL PF01436.21 EFA82478.1 - 0.044 13.8 0.2 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 NHL repeat zf-B_box PF00643.24 EFA82479.1 - 0.026 14.7 12.4 0.026 14.7 12.4 2.0 2 0 0 2 2 2 0 B-box zinc finger zf-UBP PF02148.19 EFA82479.1 - 0.51 10.7 8.3 1.3 9.4 5.2 2.5 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein HOOK PF05622.12 EFA82480.1 - 9.9e-53 179.3 121.7 3.7e-28 98.1 23.5 4.0 1 1 3 4 4 4 4 HOOK protein CH PF00307.31 EFA82480.1 - 0.0033 17.6 0.1 0.0033 17.6 0.1 3.7 3 1 0 3 3 3 1 Calponin homology (CH) domain ATG16 PF08614.11 EFA82480.1 - 0.0064 16.7 18.1 0.0064 16.7 18.1 5.6 3 2 2 5 5 5 2 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EFA82480.1 - 0.0081 16.2 22.5 0.0081 16.2 22.5 6.9 2 2 4 6 6 6 2 TPR/MLP1/MLP2-like protein CH_2 PF06294.11 EFA82480.1 - 0.12 12.6 0.1 0.12 12.6 0.1 3.4 3 0 0 3 3 3 0 CH-like domain in sperm protein AAA_13 PF13166.6 EFA82480.1 - 0.61 8.7 87.3 0.039 12.6 41.0 3.3 1 1 2 3 3 3 0 AAA domain CobU PF02283.16 EFA82480.1 - 1.4 8.5 9.8 0.3 10.6 4.5 2.7 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Leu_zip PF15294.6 EFA82480.1 - 1.9 7.9 100.9 0.022 14.3 10.3 4.3 3 1 1 4 4 4 0 Leucine zipper DAO PF01266.24 EFA82481.1 - 2.4e-49 168.8 0.0 3.1e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EFA82481.1 - 1.4e-38 131.6 0.6 5.1e-38 129.8 0.1 2.2 3 0 0 3 3 3 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EFA82481.1 - 2.1e-10 40.3 0.9 0.00033 19.9 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 EFA82481.1 - 3.9e-06 26.2 0.3 0.029 13.5 0.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFA82481.1 - 9e-06 25.3 0.5 0.0067 15.8 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFA82481.1 - 0.0051 16.1 0.2 0.033 13.4 0.2 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFA82481.1 - 0.0065 15.8 1.1 0.1 11.9 1.0 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFA82481.1 - 0.014 15.6 0.4 0.047 13.9 0.3 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFA82481.1 - 0.055 12.2 0.1 0.096 11.4 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein DUF433 PF04255.14 EFA82481.1 - 0.21 11.5 0.3 0.76 9.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF433) SAM_MT PF04445.13 EFA82482.1 - 4.9e-49 166.8 0.1 1e-48 165.8 0.1 1.5 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase SOBP PF15279.6 EFA82482.1 - 0.074 13.6 3.9 0.13 12.8 3.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Peptidase_S66 PF02016.15 EFA82482.1 - 0.19 11.8 0.3 1.7 8.8 0.0 2.8 4 0 0 4 4 4 0 LD-carboxypeptidase N-terminal domain CCDC50_N PF15295.6 EFA82482.1 - 0.86 9.8 15.3 0.044 13.9 8.8 2.2 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus HSP20 PF00011.21 EFA82484.1 - 2e-09 37.5 7.3 3.2e-05 24.0 0.0 3.7 2 1 2 4 4 4 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA82484.1 - 0.048 13.2 0.0 0.17 11.5 0.0 2.0 1 1 0 1 1 1 0 HSP20-like domain found in ArsA Hid1 PF12722.7 EFA82484.1 - 0.2 9.8 26.9 0.25 9.5 26.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pantoate_ligase PF02569.15 EFA82485.1 - 2.3e-92 309.0 0.1 2.6e-92 308.8 0.1 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase 5_nucleotid PF05761.14 EFA82485.1 - 0.11 11.3 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family ubiquitin PF00240.23 EFA82486.1 - 7.7e-186 602.3 36.4 1.5e-32 111.2 0.6 6.9 6 1 1 7 7 7 6 Ubiquitin family Rad60-SLD PF11976.8 EFA82486.1 - 9.1e-86 281.7 31.3 1e-14 54.1 0.6 6.3 6 1 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA82486.1 - 5.1e-28 97.4 16.0 0.0012 19.3 0.1 8.0 6 6 0 6 6 6 5 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA82486.1 - 3.5e-20 72.2 12.6 0.074 13.4 0.1 6.1 5 1 1 6 6 6 6 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA82486.1 - 1.4e-19 70.3 3.4 0.36 10.9 0.0 6.9 6 4 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFA82486.1 - 5.5e-19 67.9 10.6 0.1 12.5 0.0 6.3 6 0 0 6 6 6 6 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFA82486.1 - 4.7e-17 62.4 3.3 0.84 10.2 0.0 6.2 1 1 2 6 6 6 5 DUF2407 ubiquitin-like domain DUF2870 PF11069.8 EFA82486.1 - 5.6e-09 36.3 0.0 48 4.4 0.0 6.8 6 0 0 6 6 6 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EFA82486.1 - 1.1e-07 31.5 3.8 2.9 7.2 0.0 4.8 5 0 0 5 5 5 4 RNA methyltransferase Ubiquitin_4 PF18036.1 EFA82486.1 - 3.8e-07 30.0 32.4 41 4.3 0.0 10.9 11 0 0 11 11 11 0 Ubiquitin-like domain DUF969 PF06149.12 EFA82486.1 - 5.3e-07 29.3 0.1 15 4.9 0.0 5.8 5 1 1 6 6 6 0 Protein of unknown function (DUF969) Big_3_3 PF13750.6 EFA82486.1 - 1.3e-06 28.1 0.1 23 4.6 0.0 5.2 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 3) UDP-g_GGTase PF06427.11 EFA82486.1 - 2.7e-06 27.5 8.4 12 6.1 0.1 5.8 6 0 0 6 6 6 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF3861 PF12977.7 EFA82486.1 - 3.4e-05 23.9 3.9 59 3.9 0.0 5.6 6 0 0 6 6 6 0 Domain of Unknown Function with PDB structure (DUF3861) ORF11CD3 PF10549.9 EFA82486.1 - 5.3e-05 23.2 1.5 1.5e+02 2.6 0.0 7.0 11 0 0 11 11 6 0 ORF11CD3 domain DUF3435 PF11917.8 EFA82486.1 - 0.00011 21.3 1.1 37 3.1 0.0 5.1 5 0 0 5 5 5 0 Protein of unknown function (DUF3435) Big_7 PF17957.1 EFA82486.1 - 0.00015 22.5 0.1 1.8e+02 3.0 0.0 5.0 5 0 0 5 5 5 0 Bacterial Ig domain Corona_NS2A PF05213.12 EFA82486.1 - 0.00049 19.5 0.1 74 2.6 0.0 4.8 5 0 0 5 5 5 0 Coronavirus NS2A protein ACT_5 PF13710.6 EFA82486.1 - 0.0011 18.8 5.7 67 3.4 0.0 5.2 5 0 0 5 5 5 0 ACT domain YcgR_2 PF12945.7 EFA82486.1 - 0.0017 18.5 10.3 48 4.2 0.1 5.3 5 0 0 5 5 5 0 Flagellar protein YcgR Imm12 PF15560.6 EFA82486.1 - 0.006 16.5 3.6 1.2e+02 2.6 0.0 4.9 5 0 0 5 5 5 0 Immunity protein 12 NEAT PF05031.12 EFA82486.1 - 0.053 14.1 8.2 41 4.8 0.6 4.6 2 1 3 5 5 5 0 Iron Transport-associated domain Glyco_tran_WecB PF03808.13 EFA82486.1 - 0.16 11.9 0.0 3.4e+02 1.1 0.0 4.2 5 0 0 5 5 5 0 Glycosyl transferase WecB/TagA/CpsF family ProRS-C_2 PF09181.10 EFA82486.1 - 6 7.1 9.1 3.1e+02 1.6 0.1 4.8 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal Choline_transpo PF04515.12 EFA82487.1 - 1.8e-101 339.6 38.6 1.8e-101 339.6 38.6 2.7 3 0 0 3 3 3 1 Plasma-membrane choline transporter NIPSNAP PF07978.13 EFA82488.1 - 2.5e-47 159.3 0.5 2.2e-22 79.2 0.1 2.1 2 0 0 2 2 2 2 NIPSNAP EGF_2 PF07974.13 EFA82489.1 - 0.36 11.2 14.0 0.71 10.3 14.0 1.5 1 0 0 1 1 1 0 EGF-like domain vWA-TerF-like PF10138.9 EFA82490.1 - 5.5e-10 39.7 0.0 7.2e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.6 EFA82490.1 - 2.5e-06 27.5 0.0 3.9e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFA82490.1 - 4.3e-06 27.1 0.0 5.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA82490.1 - 2.5e-05 24.9 0.0 4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DHO_dh PF01180.21 EFA82491.1 - 8e-20 71.2 0.0 2.9e-16 59.5 0.0 2.0 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Dus PF01207.17 EFA82491.1 - 5.8e-05 22.3 0.2 0.00063 18.9 0.1 2.0 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 EFA82491.1 - 0.037 13.0 0.0 0.26 10.3 0.0 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase DUF2052 PF09747.9 EFA82492.1 - 0.58 10.2 15.5 0.18 11.9 11.3 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Peptidase_S30 PF01577.16 EFA82492.1 - 0.7 9.5 15.0 0.074 12.7 10.8 1.5 2 0 0 2 2 2 0 Potyvirus P1 protease Mitofilin PF09731.9 EFA82492.1 - 8.8 5.0 21.0 11 4.7 21.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein MEKHLA PF08670.11 EFA82493.1 - 0.14 12.1 0.3 0.52 10.2 0.1 2.0 2 0 0 2 2 2 0 MEKHLA domain zf-B_box PF00643.24 EFA82494.1 - 0.047 13.8 12.8 0.13 12.4 12.8 1.8 1 0 0 1 1 1 0 B-box zinc finger IBR PF01485.21 EFA82494.1 - 1.6 9.0 8.1 4 7.7 8.1 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DAP3 PF10236.9 EFA82495.1 - 0.011 14.9 0.0 0.027 13.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 EFA82495.1 - 0.018 15.4 0.3 0.061 13.7 0.0 2.1 2 0 0 2 2 2 0 RNA helicase DUF2075 PF09848.9 EFA82495.1 - 0.093 12.0 0.0 0.093 12.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Peroxin-3 PF04882.12 EFA82495.1 - 5.9 5.8 9.0 9 5.2 9.0 1.2 1 0 0 1 1 1 0 Peroxin-3 LPD11 PF18824.1 EFA82496.1 - 0.012 15.6 0.2 0.039 14.0 0.2 1.9 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 11 RT_RNaseH PF17917.1 EFA82497.1 - 2.1e-28 98.6 0.0 1.3e-27 96.2 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA82497.1 - 6.7e-28 96.7 0.0 1.7e-27 95.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EFA82497.1 - 1.7e-14 53.6 0.0 3.8e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 EFA82497.1 - 9.4e-14 51.5 0.1 1.9e-13 50.4 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EFA82497.1 - 2.4e-13 50.3 0.0 5.1e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 EFA82497.1 - 0.04 13.7 0.2 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain Ras PF00071.22 EFA82501.1 - 1.4e-40 138.6 0.0 1.7e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82501.1 - 1e-29 103.2 0.1 1.7e-29 102.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82501.1 - 3e-12 46.3 0.1 4e-12 45.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA82501.1 - 9.2e-07 28.4 0.0 1.4e-05 24.6 0.0 2.0 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFA82501.1 - 0.00055 19.4 0.0 0.00081 18.9 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 EFA82501.1 - 0.0012 18.9 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain GTP_EFTU PF00009.27 EFA82501.1 - 0.0035 16.9 0.3 0.043 13.3 0.0 2.3 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA82501.1 - 0.0059 16.7 0.0 0.0093 16.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EFA82501.1 - 0.0087 15.5 0.0 0.024 14.1 0.0 1.7 2 0 0 2 2 2 1 Bacterial TniB protein ATP_bind_1 PF03029.17 EFA82501.1 - 0.02 14.7 0.2 0.075 12.8 0.1 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EFA82501.1 - 0.058 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFA82501.1 - 0.069 12.9 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_pol_Rbc25 PF08292.12 EFA82502.1 - 8.4e-33 113.4 0.4 8.4e-33 113.4 0.4 2.1 2 0 0 2 2 2 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EFA82502.1 - 5.3e-11 42.7 0.0 8.5e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 NOA36 PF06524.12 EFA82502.1 - 4.9 6.4 10.2 6.1 6.1 10.2 1.2 1 0 0 1 1 1 0 NOA36 protein Lactamase_B_6 PF16661.5 EFA82503.1 - 4e-55 186.3 0.0 7.8e-55 185.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EFA82503.1 - 1.5e-16 61.1 7.1 2.4e-13 50.6 0.0 3.4 3 1 1 4 4 4 2 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EFA82503.1 - 3.9e-15 56.1 0.0 9.5e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EFA82503.1 - 3.5e-08 33.3 0.0 1.1e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EFA82503.1 - 0.0011 19.0 0.0 0.0028 17.7 0.0 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFA82503.1 - 0.013 15.0 0.0 0.028 13.9 0.0 1.5 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Thioredox_DsbH PF03190.15 EFA82504.1 - 1.4e-75 252.7 0.1 7.7e-75 250.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EFA82504.1 - 1.2e-08 35.0 0.0 2.5e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like C5-epim_C PF06662.13 EFA82504.1 - 2.4e-06 27.2 0.3 0.079 12.5 0.0 2.9 2 0 0 2 2 2 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 EFA82504.1 - 0.0014 17.8 0.6 0.32 10.0 0.0 2.8 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 AAA_5 PF07728.14 EFA82505.1 - 8.1e-07 29.1 0.0 0.00035 20.6 0.0 3.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) IBR PF01485.21 EFA82505.1 - 8.1e-06 26.0 20.1 0.00016 21.8 6.5 3.0 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain AAA_22 PF13401.6 EFA82505.1 - 0.0021 18.3 0.0 1.3 9.3 0.0 3.4 2 0 0 2 2 2 1 AAA domain AAA_6 PF12774.7 EFA82505.1 - 0.003 16.6 0.0 0.0089 15.0 0.0 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA PF00004.29 EFA82505.1 - 0.0035 17.8 0.4 0.036 14.5 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DUF1281 PF06924.11 EFA82505.1 - 0.032 13.8 0.4 11 5.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1281) ATP-synt_ab PF00006.25 EFA82505.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.7 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ABC_tran PF00005.27 EFA82505.1 - 0.17 12.4 0.9 17 5.9 0.0 3.6 3 0 0 3 3 3 0 ABC transporter DUF5389 PF17364.2 EFA82507.1 - 0.044 13.8 1.1 0.063 13.3 1.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5389) Tetraspanin PF00335.20 EFA82507.1 - 0.06 13.0 4.1 0.081 12.6 4.1 1.1 1 0 0 1 1 1 0 Tetraspanin family UL45 PF05473.12 EFA82507.1 - 1.7 8.2 4.7 10 5.7 4.7 1.9 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like FixH PF05751.11 EFA82507.1 - 4.9 7.2 9.9 3.9 7.5 1.9 2.2 2 0 0 2 2 2 0 FixH Elongin_A PF06881.11 EFA82509.1 - 3.6e-14 53.1 0.7 4.5e-14 52.8 0.7 1.1 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Retrotran_gag_2 PF14223.6 EFA82509.1 - 0.06 13.0 0.9 2.2 7.9 0.3 2.1 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type AMP-binding PF00501.28 EFA82510.1 - 1.7e-88 297.1 0.0 2.1e-88 296.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA82510.1 - 2.9e-20 73.0 0.0 1.5e-19 70.7 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EFA82510.1 - 2.3e-19 69.1 1.0 2.3e-19 69.1 1.0 2.1 2 1 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus FAM104 PF15434.6 EFA82510.1 - 3.6 8.2 12.1 6.5 7.4 12.1 1.3 1 0 0 1 1 1 0 Family 104 AAA PF00004.29 EFA82511.1 - 2.2e-41 141.4 0.0 3.6e-41 140.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA82511.1 - 4.7e-08 32.7 0.1 8.8e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFA82511.1 - 4.8e-08 32.8 0.4 1e-07 31.8 0.4 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EFA82511.1 - 7.3e-06 26.3 0.3 0.0024 18.1 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFA82511.1 - 2.5e-05 24.5 0.0 5.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EFA82511.1 - 3.1e-05 23.3 0.0 5.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EFA82511.1 - 0.00016 21.7 1.0 0.0011 19.0 0.3 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA82511.1 - 0.00037 20.9 0.1 0.0035 17.7 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFA82511.1 - 0.00082 19.1 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 EFA82511.1 - 0.004 16.4 0.0 0.73 9.0 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain ATPase PF06745.13 EFA82511.1 - 0.0051 16.2 0.1 0.29 10.4 0.1 2.3 1 1 1 2 2 2 1 KaiC RNA_helicase PF00910.22 EFA82511.1 - 0.014 15.8 0.0 0.043 14.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 EFA82511.1 - 0.016 15.0 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 EFA82511.1 - 0.017 15.0 0.0 0.08 12.8 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EFA82511.1 - 0.019 14.2 0.1 0.043 13.0 0.0 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain Sigma54_activat PF00158.26 EFA82511.1 - 0.026 14.3 0.1 0.13 12.0 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain NACHT PF05729.12 EFA82511.1 - 0.026 14.4 0.1 0.22 11.4 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_25 PF13481.6 EFA82511.1 - 0.033 13.8 0.4 1 8.9 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 EFA82511.1 - 0.04 14.1 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFA82511.1 - 0.046 13.5 0.2 0.12 12.0 0.2 1.9 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 EFA82511.1 - 0.046 13.2 0.1 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein TsaE PF02367.17 EFA82511.1 - 0.066 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EFA82511.1 - 0.078 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EFA82511.1 - 0.079 13.0 0.1 0.64 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFA82511.1 - 0.089 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFA82511.1 - 0.1 12.1 0.0 0.27 10.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 EFA82511.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Voltage_CLC PF00654.20 EFA82512.1 - 8.4e-102 341.0 22.8 8.7e-102 341.0 15.3 2.1 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 EFA82512.1 - 5.2e-16 58.8 0.4 4.9e-07 30.1 0.0 3.0 3 0 0 3 3 3 2 CBS domain LAT PF15234.6 EFA82513.1 - 0.095 12.4 0.1 0.095 12.4 0.1 1.9 3 0 0 3 3 3 0 Linker for activation of T-cells Beta_helix PF13229.6 EFA82514.1 - 2.3e-06 27.5 22.6 2.3e-06 27.5 22.6 3.6 2 1 2 4 4 4 3 Right handed beta helix region PH PF00169.29 EFA82515.1 - 1.2e-29 102.9 8.4 1.4e-15 57.7 0.6 3.1 3 0 0 3 3 3 2 PH domain LIM PF00412.22 EFA82515.1 - 5.4e-25 87.4 31.8 1.2e-12 47.9 3.6 3.5 3 0 0 3 3 3 3 LIM domain PH_11 PF15413.6 EFA82515.1 - 3.3e-08 33.9 21.3 3.8e-05 24.0 4.4 4.7 4 2 0 4 4 4 2 Pleckstrin homology domain PH_9 PF15410.6 EFA82515.1 - 6e-08 33.1 1.2 0.028 14.8 0.0 3.7 2 1 1 3 3 3 3 Pleckstrin homology domain PH_8 PF15409.6 EFA82515.1 - 0.001 19.3 0.0 0.0036 17.5 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 EFA82515.1 - 0.032 14.1 0.1 0.51 10.1 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Stc1 PF12898.7 EFA82515.1 - 0.097 13.2 0.3 0.097 13.2 0.3 4.0 1 1 3 4 4 4 0 Stc1 domain FUR PF01475.19 EFA82515.1 - 1 9.5 9.2 10 6.3 1.5 3.3 3 0 0 3 3 3 0 Ferric uptake regulator family SL4P PF17618.2 EFA82516.1 - 0.072 13.1 4.3 0.2 11.7 1.7 2.5 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein Transket_pyr PF02779.24 EFA82517.1 - 3.1e-66 222.5 0.0 5.7e-66 221.6 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EFA82517.1 - 8.7e-66 221.9 0.0 1.2e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EFA82517.1 - 9.3e-48 161.8 0.0 1.7e-47 160.9 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EFA82517.1 - 1.5e-16 59.7 1.4 1.5e-16 59.7 1.4 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus GEMIN8 PF15348.6 EFA82518.1 - 7.9 6.7 37.6 8.4 6.6 20.2 2.6 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Esterase PF00756.20 EFA82519.1 - 4.7e-48 164.0 0.0 5.5e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EFA82519.1 - 0.00028 20.4 0.0 0.0004 19.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFA82519.1 - 0.013 14.8 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EFA82519.1 - 0.037 12.9 0.0 0.063 12.2 0.0 1.4 1 1 0 1 1 1 0 Chlorophyllase enzyme Esterase_phd PF10503.9 EFA82519.1 - 0.076 12.5 0.0 0.78 9.2 0.0 2.0 2 0 0 2 2 2 0 Esterase PHB depolymerase Semialdhyde_dhC PF02774.18 EFA82520.1 - 1.4e-31 110.0 0.0 2.4e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EFA82520.1 - 4.4e-29 101.4 0.0 7.7e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 EFA82520.1 - 0.0019 18.9 1.0 0.006 17.3 0.0 2.3 3 0 0 3 3 3 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sacchrp_dh_NADP PF03435.18 EFA82520.1 - 0.0027 17.9 0.2 0.016 15.5 0.0 2.3 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 EFA82520.1 - 0.0031 17.6 0.0 0.0063 16.6 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.20 EFA82520.1 - 0.035 13.7 0.1 0.098 12.2 0.0 1.7 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Tmemb_cc2 PF10267.9 EFA82520.1 - 0.16 11.1 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein PigN PF04987.14 EFA82521.1 - 1.6e-121 406.4 42.1 2.8e-121 405.6 42.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EFA82521.1 - 2.6e-09 37.2 0.1 5.8e-08 32.7 0.1 2.1 1 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFA82521.1 - 1.9e-06 27.5 0.0 3.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EFA82521.1 - 0.0015 17.9 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF2116 PF09889.9 EFA82521.1 - 0.49 10.4 2.9 9.6 6.3 0.6 3.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Myb_Cef PF11831.8 EFA82522.1 - 1.4e-41 142.6 13.4 1.4e-41 142.6 13.4 3.3 3 1 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EFA82522.1 - 4.4e-21 74.8 5.3 1.4e-10 41.2 0.8 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA82522.1 - 7.4e-18 64.6 3.4 1.6e-12 47.5 2.9 3.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFA82522.1 - 0.0017 18.5 2.4 0.28 11.4 0.1 2.8 2 0 0 2 2 2 2 SANT/Myb-like domain of DAMP1 Cytochrom_B562 PF07361.11 EFA82522.1 - 4 8.2 14.8 0.18 12.5 3.1 3.8 2 1 1 3 3 3 0 Cytochrome b562 GYF PF02213.16 EFA82523.1 - 8.5e-17 60.6 0.4 8.5e-17 60.6 0.4 2.6 3 0 0 3 3 3 1 GYF domain Glycos_transf_2 PF00535.26 EFA82524.1 - 4.2e-24 85.3 0.0 8.8e-24 84.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFA82524.1 - 5.9e-13 49.2 0.0 9.7e-13 48.5 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFA82524.1 - 2e-11 43.9 0.1 4.6e-11 42.7 0.1 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EFA82524.1 - 3.1e-05 23.6 0.3 5.9e-05 22.6 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_trans_2_3 PF13632.6 EFA82524.1 - 0.0085 16.0 1.3 0.061 13.2 1.3 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 MGAT2 PF05060.14 EFA82524.1 - 0.028 13.5 0.6 0.34 9.9 0.7 2.0 2 0 0 2 2 2 0 N-acetylglucosaminyltransferase II (MGAT2) RINGv PF12906.7 EFA82525.1 - 5.9e-14 51.9 6.2 1e-13 51.1 6.2 1.4 1 0 0 1 1 1 1 RING-variant domain DUF2722 PF10846.8 EFA82525.1 - 0.003 16.6 0.8 0.003 16.6 0.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Tim54 PF11711.8 EFA82525.1 - 0.0034 16.2 0.1 0.38 9.5 0.0 2.3 2 0 0 2 2 2 2 Inner membrane protein import complex subunit Tim54 Pex14_N PF04695.13 EFA82525.1 - 0.029 15.0 7.7 2.7 8.7 5.6 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-RING_2 PF13639.6 EFA82525.1 - 0.038 14.3 6.2 0.072 13.4 6.2 1.5 1 0 0 1 1 1 0 Ring finger domain DUF4834 PF16118.5 EFA82525.1 - 0.13 13.3 0.0 0.13 13.3 0.0 5.9 7 1 0 7 7 7 0 Domain of unknown function (DUF4834) SARAF PF06682.12 EFA82525.1 - 0.16 11.6 3.2 6 6.4 0.0 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S24 PF00717.23 EFA82526.1 - 1.3e-07 31.5 0.3 2e-07 30.8 0.3 1.4 1 0 0 1 1 1 1 Peptidase S24-like Vps26 PF03643.15 EFA82527.1 - 3.1e-44 151.0 0.2 4.1e-44 150.7 0.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EFA82527.1 - 1.4e-06 28.4 0.2 1.2e-05 25.5 0.1 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Ependymin PF00811.18 EFA82528.1 - 1.8e-07 31.4 0.9 3.5e-07 30.5 0.9 1.4 1 0 0 1 1 1 1 Ependymin ketoacyl-synt PF00109.26 EFA82529.1 - 1.1e-69 234.8 0.0 1.7e-69 234.3 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA82529.1 - 1.2e-54 186.0 0.0 1.8e-54 185.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA82529.1 - 1.1e-34 119.0 0.1 2.4e-34 117.9 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA82529.1 - 2.2e-33 115.7 0.0 6.3e-32 110.9 0.0 2.8 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 EFA82529.1 - 3.3e-23 82.4 0.0 1.3e-22 80.4 0.0 1.8 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA82529.1 - 1.4e-15 57.7 0.0 3.9e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA82529.1 - 5e-15 56.0 0.0 2.6e-14 53.8 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA82529.1 - 1.2e-11 44.5 0.0 7.2e-09 35.4 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EFA82529.1 - 1.7e-08 35.6 0.0 4.3e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFA82529.1 - 3e-07 30.4 0.0 8.6e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EFA82529.1 - 4.7e-07 29.8 0.0 1.7e-06 28.0 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFA82529.1 - 5.7e-06 26.1 0.0 1.6e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_25 PF13649.6 EFA82529.1 - 1.6e-05 25.5 0.0 0.00013 22.6 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA82529.1 - 3.6e-05 24.3 0.0 0.00018 22.1 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA82529.1 - 0.00074 19.3 0.1 0.0042 16.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EFA82529.1 - 0.0012 19.1 0.1 0.005 17.2 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 EFA82529.1 - 0.0023 17.7 0.0 0.007 16.1 0.0 1.8 1 0 0 1 1 1 1 Lysine methyltransferase DUF938 PF06080.12 EFA82529.1 - 0.0053 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Thiolase_N PF00108.23 EFA82529.1 - 0.016 14.6 0.0 0.048 13.0 0.0 1.7 2 0 0 2 2 2 0 Thiolase, N-terminal domain ADH_N PF08240.12 EFA82529.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain MarB PF13999.6 EFA82530.1 - 0.076 12.9 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 MarB protein Papilloma_E5A PF05776.12 EFA82531.1 - 1.3 9.5 6.2 1.9 8.9 6.0 1.4 1 1 0 1 1 1 0 Papillomavirus E5A protein RVT_1 PF00078.27 EFA82532.1 - 0.00084 18.9 0.0 0.0032 17.0 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFA82533.1 - 0.014 16.2 1.2 0.065 14.1 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger NinG PF05766.12 EFA82533.1 - 0.077 12.9 0.6 0.11 12.4 0.6 1.2 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein ketoacyl-synt PF00109.26 EFA82534.1 - 1.1e-69 234.9 0.0 1.6e-69 234.3 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA82534.1 - 1.2e-52 179.4 0.0 1.8e-52 178.8 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA82534.1 - 4.6e-35 120.2 0.1 1e-34 119.0 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA82534.1 - 5e-34 117.8 0.0 1.4e-32 113.1 0.0 2.8 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 EFA82534.1 - 1.3e-22 80.4 0.0 5.4e-22 78.4 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA82534.1 - 7.6e-16 58.6 0.1 1.9e-15 57.3 0.1 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA82534.1 - 8.7e-15 55.3 0.0 3.8e-14 53.2 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA82534.1 - 4.6e-10 39.3 0.0 1.4e-07 31.1 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 EFA82534.1 - 1.1e-07 31.9 0.0 3.5e-07 30.2 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFA82534.1 - 4.3e-07 29.9 0.0 1.2e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EFA82534.1 - 1.1e-06 29.7 0.0 3.3e-06 28.2 0.0 1.8 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EFA82534.1 - 3.1e-05 24.6 0.0 0.00041 21.0 0.0 3.0 3 1 1 4 4 2 1 Methyltransferase domain adh_short_C2 PF13561.6 EFA82534.1 - 3.6e-05 23.4 0.0 9.5e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_11 PF08241.12 EFA82534.1 - 0.00013 22.5 0.0 0.00073 20.1 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain PP-binding PF00550.25 EFA82534.1 - 0.0013 19.1 0.1 0.005 17.2 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 EFA82534.1 - 0.0053 16.6 0.1 0.033 14.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain DUF938 PF06080.12 EFA82534.1 - 0.0056 16.5 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 EFA82534.1 - 0.014 15.2 0.0 0.045 13.5 0.0 1.9 1 0 0 1 1 1 0 Lysine methyltransferase Thiolase_N PF00108.23 EFA82534.1 - 0.015 14.6 0.0 0.048 13.0 0.0 1.7 2 0 0 2 2 2 0 Thiolase, N-terminal domain ADH_N PF08240.12 EFA82534.1 - 0.023 14.6 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DUF3231 PF11553.8 EFA82535.1 - 0.033 13.8 0.1 0.11 12.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3231) zf-primase PF09329.11 EFA82536.1 - 3e-05 23.8 5.4 0.069 13.0 1.4 3.0 1 1 1 2 2 2 2 Primase zinc finger RELT PF12606.8 EFA82536.1 - 2.1 7.4 5.0 0.89 8.6 0.3 2.5 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 PRELI PF04707.14 EFA82537.1 - 7.2e-48 162.4 0.0 1.3e-47 161.6 0.0 1.3 1 0 0 1 1 1 1 PRELI-like family Baculo_PEP_C PF04513.12 EFA82537.1 - 3.7e-05 23.8 1.3 7.1e-05 22.9 1.3 1.5 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Peptidase_S46 PF10459.9 EFA82537.1 - 0.00036 19.3 2.4 0.00047 18.9 2.4 1.1 1 0 0 1 1 1 1 Peptidase S46 ApoLp-III PF07464.11 EFA82537.1 - 0.00077 19.6 4.8 0.0013 18.8 4.8 1.3 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) CHAD PF05235.14 EFA82537.1 - 0.0013 18.8 1.2 0.0017 18.3 1.2 1.1 1 0 0 1 1 1 1 CHAD domain DLP_helical PF18709.1 EFA82537.1 - 0.005 16.1 3.2 0.0074 15.5 3.2 1.3 1 0 0 1 1 1 1 Dynamin-like helical domain Golgin_A5 PF09787.9 EFA82537.1 - 0.0078 15.7 3.9 0.011 15.3 3.9 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 V_ATPase_I PF01496.19 EFA82537.1 - 0.0098 13.9 1.8 0.012 13.6 1.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family YkyA PF10368.9 EFA82537.1 - 0.02 14.6 9.6 0.039 13.6 9.6 1.4 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Phasin PF05597.11 EFA82537.1 - 0.028 14.4 5.7 0.37 10.8 6.1 2.0 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3584 PF12128.8 EFA82537.1 - 0.036 11.6 7.3 0.044 11.3 7.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Exonuc_VII_L PF02601.15 EFA82537.1 - 0.038 13.6 1.1 0.047 13.2 1.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 EFA82537.1 - 0.052 12.9 2.8 0.078 12.3 2.8 1.3 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 EFA82537.1 - 0.058 12.7 4.8 0.076 12.4 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4735 PF15882.5 EFA82537.1 - 0.067 12.6 0.2 0.093 12.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) PIN_8 PF18476.1 EFA82537.1 - 0.07 13.0 3.5 0.1 12.4 3.5 1.2 1 0 0 1 1 1 0 PIN like domain DUF4634 PF15465.6 EFA82537.1 - 0.073 13.4 1.6 0.3 11.4 0.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4634) CdvA PF18822.1 EFA82537.1 - 0.08 12.8 8.8 1.4 8.8 3.7 2.3 1 1 1 2 2 2 0 CdvA-like coiled-coil domain NusB PF01029.18 EFA82537.1 - 0.1 12.9 2.4 0.16 12.2 2.0 1.5 1 1 0 1 1 1 0 NusB family MRP-S26 PF14943.6 EFA82537.1 - 0.19 11.6 9.9 0.37 10.7 9.7 1.5 1 1 1 2 2 2 0 Mitochondrial ribosome subunit S26 DUF1664 PF07889.12 EFA82537.1 - 0.7 9.9 6.3 8 6.5 3.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Phage_Mu_Gam PF07352.12 EFA82537.1 - 0.75 9.7 9.2 7.2 6.5 4.1 2.3 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein DUF883 PF05957.13 EFA82537.1 - 0.78 10.4 6.5 1 10.0 1.5 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Fzo_mitofusin PF04799.13 EFA82537.1 - 1.1 8.7 5.2 32 4.0 4.5 2.3 1 1 1 2 2 2 0 fzo-like conserved region Fib_alpha PF08702.10 EFA82537.1 - 1.6 8.9 5.1 4.8 7.4 4.9 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1640 PF07798.11 EFA82537.1 - 1.8 8.6 9.4 6.9 6.7 9.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) ACCA PF03255.14 EFA82537.1 - 4 7.3 7.3 4.3 7.2 0.3 2.2 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DEAD PF00270.29 EFA82538.1 - 3.7e-16 59.4 0.0 9.7e-16 58.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase COesterase PF00135.28 EFA82538.1 - 3.4e-12 46.0 0.4 1.1e-11 44.3 0.4 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA82538.1 - 5.4e-11 42.8 0.0 1.3e-10 41.5 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF915 PF06028.11 EFA82538.1 - 0.00014 21.3 0.0 0.00029 20.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase2 PF12740.7 EFA82538.1 - 0.00015 20.7 0.1 0.00045 19.2 0.1 1.7 2 0 0 2 2 2 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 EFA82538.1 - 0.00018 22.2 0.0 0.00032 21.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA82538.1 - 0.00065 19.0 2.0 0.038 13.2 0.4 2.6 2 1 0 2 2 2 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EFA82538.1 - 0.0013 18.3 0.1 0.0025 17.3 0.1 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.15 EFA82538.1 - 0.0034 16.6 0.0 0.0071 15.6 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase FSH1 PF03959.13 EFA82538.1 - 0.0038 16.9 0.1 0.011 15.3 0.0 1.8 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Thioesterase PF00975.20 EFA82538.1 - 0.0065 16.6 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 EFA82538.1 - 0.0068 15.9 0.1 0.035 13.6 0.1 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF900 PF05990.12 EFA82538.1 - 0.013 15.0 0.0 0.078 12.5 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) CMS1 PF14617.6 EFA82538.1 - 0.04 13.2 0.0 0.093 12.1 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit LIDHydrolase PF10230.9 EFA82538.1 - 0.074 12.6 0.4 0.17 11.4 0.1 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase PGAP1 PF07819.13 EFA82538.1 - 0.12 12.1 0.1 0.12 12.1 0.1 1.7 2 0 0 2 2 2 0 PGAP1-like protein Abhydrolase_1 PF00561.20 EFA82538.1 - 0.77 9.3 2.3 2.7 7.6 1.4 2.2 1 1 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_M16 PF00675.20 EFA82539.1 - 5.5e-12 45.9 0.0 1.4e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFA82539.1 - 3.4e-08 33.7 0.0 3e-07 30.6 0.0 2.4 2 0 0 2 2 2 1 Peptidase M16 inactive domain DUF859 PF05895.12 EFA82539.1 - 0.013 14.1 0.1 0.02 13.4 0.1 1.2 1 0 0 1 1 1 0 Siphovirus protein of unknown function (DUF859) RXT2_N PF08595.11 EFA82539.1 - 0.71 9.9 10.3 1.4 8.9 10.3 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 EFA82539.1 - 0.73 9.5 7.8 1.4 8.6 7.8 1.4 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 EFA82539.1 - 0.87 9.3 14.1 1.5 8.5 14.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CobT PF06213.12 EFA82539.1 - 0.95 8.8 12.6 1.6 8.0 12.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 EFA82539.1 - 1.4 8.3 14.3 2 7.8 14.3 1.1 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 EFA82539.1 - 2.3 8.1 6.8 4.4 7.2 6.8 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 EFA82539.1 - 2.5 6.2 16.6 4.1 5.5 16.6 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EFA82539.1 - 2.6 7.3 15.7 5 6.4 15.7 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EFA82539.1 - 2.8 6.1 12.3 5.7 5.1 12.3 1.4 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 EFA82539.1 - 3 6.9 19.7 4.7 6.3 19.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 EFA82539.1 - 4.4 7.1 14.9 8.6 6.1 14.9 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 EFA82539.1 - 7.2 4.6 22.3 11 3.9 22.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Rad1 PF02144.16 EFA82540.1 - 0.0024 17.0 0.2 0.0024 17.0 0.2 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 SID-1_RNA_chan PF13965.6 EFA82541.1 - 5.1e-51 173.8 23.9 9.4e-37 126.7 14.1 3.5 1 1 1 3 3 3 2 dsRNA-gated channel SID-1 Macoilin PF09726.9 EFA82541.1 - 0.67 8.4 10.2 0.89 8.0 10.2 1.2 1 0 0 1 1 1 0 Macoilin family Imm68 PF15583.6 EFA82542.1 - 0.077 13.2 0.5 2.4 8.3 0.0 2.7 2 1 0 2 2 2 0 Immunity protein 68 MAP65_ASE1 PF03999.12 EFA82542.1 - 0.11 11.2 0.6 0.12 11.0 0.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ATP-synt_ab PF00006.25 EFA82543.1 - 1.4e-107 358.2 0.0 2.2e-107 357.5 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EFA82543.1 - 5.2e-42 142.5 0.1 1.4e-41 141.1 0.0 1.8 2 0 0 2 2 2 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EFA82543.1 - 4.9e-17 62.2 1.9 8.1e-16 58.3 1.1 3.2 3 0 0 3 3 3 1 ATP synthase alpha/beta family, beta-barrel domain Abhydrolase_2 PF02230.16 EFA82545.1 - 5.5e-23 81.9 0.1 9.6e-21 74.6 0.1 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 EFA82545.1 - 0.043 13.4 0.0 0.32 10.5 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EFA82546.1 - 3.3e-52 177.4 0.2 7e-52 176.4 0.2 1.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EFA82546.1 - 2e-07 30.9 0.5 0.00072 19.3 0.7 2.8 2 1 0 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 EFA82546.1 - 1.7e-06 27.9 0.0 1.3e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EFA82546.1 - 2.4e-05 23.9 0.2 0.00025 20.6 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFA82546.1 - 0.0002 20.7 0.1 3.7 6.7 0.1 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA82546.1 - 0.0012 19.4 0.0 0.0056 17.3 0.0 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EFA82546.1 - 0.0094 16.0 0.0 0.039 14.1 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein DLH PF01738.18 EFA82546.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family PP-binding PF00550.25 EFA82546.1 - 0.025 14.9 0.0 0.042 14.2 0.0 1.4 1 0 0 1 1 1 0 Phosphopantetheine attachment site Abhydrolase_3 PF07859.13 EFA82546.1 - 0.037 13.9 0.0 0.069 13.0 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold DNA_pol_A_exo1 PF01612.20 EFA82548.1 - 1.1e-08 34.9 0.0 2.3e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease DUF913 PF06025.12 EFA82548.1 - 2.3 7.1 10.5 4.6 6.1 5.7 2.6 2 1 0 2 2 2 0 Domain of Unknown Function (DUF913) COesterase PF00135.28 EFA82549.1 - 1.7e-10 40.4 0.0 4.1e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA82549.1 - 9.4e-08 32.2 0.0 1.1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA82549.1 - 0.00013 21.5 0.0 0.00027 20.5 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFA82549.1 - 0.00036 20.3 0.1 0.042 13.5 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA82549.1 - 0.0038 16.5 0.0 0.98 8.6 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EFA82549.1 - 0.081 12.8 0.1 4.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Palmitoyl protein thioesterase BPA_C PF18040.1 EFA82551.1 - 0.00036 20.4 0.0 0.00054 19.8 0.0 1.4 1 0 0 1 1 1 1 beta porphyranase A C-terminal DUF1851 PF08906.11 EFA82551.1 - 0.018 15.0 0.0 0.38 10.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1851) zf-C2H2_9 PF16293.5 EFA82552.1 - 0.76 9.7 9.1 0.75 9.7 1.0 3.7 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) Phos_pyr_kin PF08543.12 EFA82554.1 - 1.4e-13 50.8 0.0 1.8e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EFA82554.1 - 9.3e-07 28.4 0.1 5e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase DUF1279 PF06916.13 EFA82555.1 - 7.1e-20 71.4 0.7 7.1e-20 71.4 0.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Ndc1_Nup PF09531.10 EFA82555.1 - 0.0037 16.0 1.2 0.0037 16.0 1.2 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFA82555.1 - 0.03 13.1 2.2 0.031 13.0 2.2 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 EFA82555.1 - 0.043 13.8 2.7 0.056 13.4 2.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SprA-related PF12118.8 EFA82555.1 - 0.21 10.7 13.5 0.26 10.4 13.5 1.1 1 0 0 1 1 1 0 SprA-related family GNAT_acetyltr_2 PF13718.6 EFA82555.1 - 0.43 9.9 5.0 0.34 10.3 3.4 1.5 1 1 1 2 2 2 0 GNAT acetyltransferase 2 TFIIA PF03153.13 EFA82555.1 - 0.67 9.9 21.1 0.82 9.6 21.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ALMT PF11744.8 EFA82555.1 - 2 7.2 6.7 2.8 6.7 6.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2407_C PF13373.6 EFA82555.1 - 2.3 8.4 6.7 1.5 9.0 3.6 2.1 1 1 1 2 2 2 0 DUF2407 C-terminal domain adh_short PF00106.25 EFA82556.1 - 5.1e-47 159.9 0.1 9.1e-47 159.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA82556.1 - 6.9e-34 117.4 0.0 1e-33 116.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ank_2 PF12796.7 EFA82556.1 - 1.4e-15 57.6 0.0 3.7e-06 27.4 0.0 3.5 2 1 2 4 4 3 3 Ankyrin repeats (3 copies) KR PF08659.10 EFA82556.1 - 4.2e-13 49.6 0.0 8e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Ank_4 PF13637.6 EFA82556.1 - 5.7e-10 39.5 0.0 0.023 15.3 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82556.1 - 0.00012 22.2 0.2 19 6.2 0.0 5.8 3 2 2 5 5 5 0 Ankyrin repeat DUF1776 PF08643.10 EFA82556.1 - 0.00015 21.3 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Ank_5 PF13857.6 EFA82556.1 - 0.00022 21.5 0.0 1.8 9.0 0.0 4.6 2 2 3 5 5 5 2 Ankyrin repeats (many copies) NAD_binding_10 PF13460.6 EFA82556.1 - 0.00029 20.8 0.1 0.00053 19.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFA82556.1 - 0.00032 20.2 0.4 0.0017 17.9 0.4 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA82556.1 - 0.008 15.3 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain ADH_zinc_N PF00107.26 EFA82556.1 - 0.09 12.8 0.1 0.29 11.1 0.1 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase ATP-sulfurylase PF01747.17 EFA82557.1 - 1.4e-81 273.0 0.0 2e-81 272.5 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EFA82557.1 - 5.6e-60 201.8 0.0 9.7e-60 201.0 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EFA82557.1 - 3.8e-47 159.9 0.0 5.6e-47 159.4 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_29 PF13555.6 EFA82557.1 - 9.4e-05 22.1 0.0 0.00022 20.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain CbiA PF01656.23 EFA82557.1 - 0.00054 20.0 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 EFA82557.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFA82557.1 - 0.0012 18.6 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFA82557.1 - 0.0029 16.9 0.0 0.0056 16.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EFA82557.1 - 0.0039 17.6 0.0 0.0068 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 EFA82557.1 - 0.004 16.6 0.0 0.0062 16.0 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 CPT PF07931.12 EFA82557.1 - 0.0052 16.6 0.0 4.1 7.2 0.0 2.3 2 0 0 2 2 2 2 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 EFA82557.1 - 0.0052 17.3 0.0 0.01 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFA82557.1 - 0.0068 16.9 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 EFA82557.1 - 0.026 14.8 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFA82557.1 - 0.033 14.1 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase T2SSE PF00437.20 EFA82557.1 - 0.05 12.6 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ParA PF10609.9 EFA82557.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase AAA_22 PF13401.6 EFA82557.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFA82557.1 - 0.12 12.9 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EFA82557.1 - 0.15 11.1 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 EFA82557.1 - 0.16 12.4 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EFA82557.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Sod_Cu PF00080.20 EFA82558.1 - 4.7e-16 59.2 0.3 8.7e-16 58.4 0.3 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PTEN_C2 PF10409.9 EFA82559.1 - 1.7e-16 60.2 2.6 3.9e-14 52.6 0.3 2.5 2 0 0 2 2 2 2 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EFA82559.1 - 5.8e-06 26.2 2.0 8.1e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFA82559.1 - 1.7e-05 25.0 0.0 4.8e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFA82559.1 - 0.00019 21.1 0.0 0.00045 19.9 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFA82559.1 - 0.0002 21.4 0.0 0.00036 20.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family CDKN3 PF05706.12 EFA82559.1 - 0.0018 18.0 0.1 0.0032 17.2 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DUF4692 PF15763.5 EFA82559.1 - 3.4 8.1 17.3 0.63 10.5 6.2 2.3 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Ank_2 PF12796.7 EFA82560.1 - 1.2e-20 73.9 4.2 3.4e-08 34.0 0.1 4.4 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82560.1 - 3.9e-19 68.7 3.4 0.0071 16.9 0.1 5.4 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82560.1 - 1.2e-13 49.9 1.6 0.32 11.7 0.0 8.3 7 1 2 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EFA82560.1 - 3.1e-13 49.6 6.4 0.0004 20.6 0.0 6.8 4 2 4 8 8 8 3 Ankyrin repeats (many copies) Dna2 PF08696.11 EFA82561.1 - 3.9e-55 186.8 3.6 4.4e-54 183.4 0.0 3.2 3 0 0 3 3 3 1 DNA replication factor Dna2 AAA_12 PF13087.6 EFA82561.1 - 3.4e-54 183.5 0.3 3.4e-54 183.5 0.3 2.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFA82561.1 - 2.9e-24 86.3 0.0 3e-17 63.3 0.0 4.9 3 2 1 4 4 4 2 AAA domain AAA_30 PF13604.6 EFA82561.1 - 1.1e-12 48.1 0.0 2e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA82561.1 - 7.6e-10 39.3 0.0 1.8e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EFA82561.1 - 0.00024 21.0 0.1 0.0022 17.9 0.0 2.6 2 0 0 2 2 2 1 Helicase Viral_helicase1 PF01443.18 EFA82561.1 - 0.00076 19.3 10.4 0.19 11.4 0.1 5.4 5 1 0 5 5 5 2 Viral (Superfamily 1) RNA helicase PRP3 PF08572.10 EFA82562.1 - 0.002 17.9 3.2 0.002 17.9 3.2 1.7 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF2722 PF10846.8 EFA82562.1 - 0.0021 17.1 1.3 0.0027 16.8 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) HA70_C PF17993.1 EFA82562.1 - 0.03 14.4 0.8 0.06 13.4 0.8 1.5 1 0 0 1 1 1 0 Haemagglutinin 70 C-terminal domain Gaa1 PF04114.14 EFA82562.1 - 0.061 12.3 0.1 0.081 11.9 0.1 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component MMgT PF10270.9 EFA82562.1 - 0.08 13.3 0.1 0.2 12.0 0.1 1.6 1 1 0 1 1 1 0 Membrane magnesium transporter NADH_dhqG_C PF09326.11 EFA82562.1 - 0.16 12.7 0.1 0.16 12.7 0.1 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal CAP PF00188.26 EFA82564.1 - 1.1e-14 55.3 0.0 1.6e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family RP853 PF17542.2 EFA82564.1 - 0.0051 16.0 0.2 0.0079 15.4 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized RP853 DIM PF08194.12 EFA82565.1 - 0.22 11.8 1.1 0.41 10.9 1.1 1.4 1 0 0 1 1 1 0 DIM protein Kelch_1 PF01344.25 EFA82566.1 - 5.6e-35 118.7 8.4 2.6e-10 39.7 0.1 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFA82566.1 - 5e-29 99.6 7.0 4.6e-07 29.9 0.0 6.5 3 2 3 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFA82566.1 - 2.2e-26 91.6 1.5 3.3e-07 30.2 0.0 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA82566.1 - 5.6e-20 70.5 4.4 0.0069 16.3 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFA82566.1 - 1.3e-17 63.6 1.0 0.00013 22.2 0.0 6.8 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA82566.1 - 2.1e-09 37.1 11.8 0.0034 17.3 0.4 4.9 5 0 0 5 5 5 3 Kelch motif DUF4047 PF13256.6 EFA82566.1 - 0.014 15.5 0.8 0.058 13.6 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Sds3 PF08598.11 EFA82566.1 - 0.23 11.4 5.4 0.42 10.6 5.4 1.4 1 0 0 1 1 1 0 Sds3-like R3H-assoc PF13902.6 EFA82566.1 - 0.53 10.7 3.0 0.31 11.4 0.7 1.7 2 0 0 2 2 2 0 R3H-associated N-terminal domain BSD PF03909.17 EFA82567.1 - 2.7e-08 33.7 2.3 7.7e-08 32.2 2.3 1.8 1 0 0 1 1 1 1 BSD domain Prp19 PF08606.11 EFA82568.1 - 1.3e-34 118.0 2.0 2.6e-34 117.0 2.0 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 EFA82568.1 - 9.4e-27 92.7 14.8 7.1e-07 29.8 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA82568.1 - 4e-13 49.5 1.6 0.13 12.6 0.0 4.9 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA82568.1 - 2.5e-11 43.8 5.0 5.4e-05 23.2 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFA82568.1 - 0.0048 16.3 3.7 1 8.7 0.0 3.2 2 1 0 3 3 3 1 WD40-like domain Str_synth PF03088.16 EFA82568.1 - 0.037 14.2 0.2 0.3 11.2 0.0 2.6 3 0 0 3 3 3 0 Strictosidine synthase SGL PF08450.12 EFA82568.1 - 0.039 13.5 0.3 0.65 9.5 0.0 2.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region zf-Nse PF11789.8 EFA82568.1 - 0.11 12.3 0.0 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit PMBR PF09373.10 EFA82568.1 - 0.14 12.3 0.0 13 6.2 0.0 2.6 2 0 0 2 2 2 0 Pseudomurein-binding repeat Cofilin_ADF PF00241.20 EFA82569.1 - 5.4e-20 71.4 0.0 6.3e-20 71.2 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF1926 PF09095.11 EFA82569.1 - 0.096 12.3 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1926) zf-C3HC4_3 PF13920.6 EFA82570.1 - 5.7e-08 32.5 4.1 1.8e-07 30.9 4.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_2 PF12796.7 EFA82570.1 - 1.2e-07 32.2 0.0 1.2e-07 32.2 0.0 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82570.1 - 3.3e-06 27.5 0.0 1e-05 26.0 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82570.1 - 3.1e-05 24.0 0.0 0.0092 16.4 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFA82570.1 - 0.00013 22.2 0.0 0.00013 22.2 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA82570.1 - 0.002 18.5 0.0 0.011 16.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Prok-RING_4 PF14447.6 EFA82570.1 - 0.093 12.6 5.3 0.29 11.0 5.3 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 COesterase PF00135.28 EFA82571.1 - 4.7e-14 52.1 0.1 2e-13 50.0 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA82571.1 - 1.6e-13 51.0 0.0 2.4e-13 50.4 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFA82571.1 - 2.6e-06 26.5 0.0 3.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 EFA82571.1 - 0.0001 21.3 0.0 0.00015 20.8 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 EFA82571.1 - 0.00011 22.9 0.0 0.00021 21.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA82571.1 - 0.00056 19.3 1.1 0.033 13.4 0.4 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 EFA82571.1 - 0.00087 18.5 0.0 0.00099 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) FSH1 PF03959.13 EFA82571.1 - 0.0009 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EFA82571.1 - 0.0027 17.2 0.1 1.1 8.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFA82571.1 - 0.019 14.6 0.3 1.9 8.0 0.0 2.7 3 0 0 3 3 3 0 alpha/beta hydrolase fold DUF676 PF05057.14 EFA82571.1 - 0.027 14.0 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Thioesterase PF00975.20 EFA82571.1 - 0.04 14.0 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain DUF915 PF06028.11 EFA82571.1 - 0.071 12.4 0.1 0.11 11.8 0.1 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF900 PF05990.12 EFA82571.1 - 0.16 11.4 0.0 0.67 9.4 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EFA82571.1 - 0.18 11.5 0.8 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein COesterase PF00135.28 EFA82572.1 - 5.2e-16 58.6 0.1 3.9e-15 55.7 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA82572.1 - 4.9e-14 52.7 0.0 6e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFA82572.1 - 8.4e-08 31.5 0.4 1.1e-07 31.1 0.4 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 EFA82572.1 - 3.1e-06 26.3 0.3 1.5e-05 24.1 0.3 2.0 1 1 0 1 1 1 1 Chlorophyllase enzyme DUF1749 PF08538.10 EFA82572.1 - 9.3e-06 24.9 0.1 1.6e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EFA82572.1 - 2.8e-05 24.8 0.0 4.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA82572.1 - 0.00038 19.8 0.6 0.15 11.3 0.3 2.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EFA82572.1 - 0.00047 19.3 0.5 0.00075 18.6 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase Abhydrolase_1 PF00561.20 EFA82572.1 - 0.00063 19.5 0.8 0.33 10.5 0.3 2.5 2 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA82572.1 - 0.0012 18.4 0.1 0.24 10.8 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF676 PF05057.14 EFA82572.1 - 0.0022 17.6 0.0 0.0036 16.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF900 PF05990.12 EFA82572.1 - 0.005 16.4 0.0 0.02 14.4 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) FSH1 PF03959.13 EFA82572.1 - 0.0072 16.0 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) PAF-AH_p_II PF03403.13 EFA82572.1 - 0.016 13.7 0.0 0.12 10.9 0.0 1.9 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II LIDHydrolase PF10230.9 EFA82572.1 - 0.016 14.7 0.2 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Thioesterase PF00975.20 EFA82572.1 - 0.018 15.2 0.1 0.035 14.2 0.1 1.5 1 0 0 1 1 1 0 Thioesterase domain DUF915 PF06028.11 EFA82572.1 - 0.018 14.4 0.2 0.029 13.7 0.2 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S10 PF00450.22 EFA82572.1 - 0.03 13.7 0.2 0.75 9.1 0.1 2.1 2 0 0 2 2 2 0 Serine carboxypeptidase DLH PF01738.18 EFA82572.1 - 0.066 12.8 0.0 4.8 6.7 0.0 2.8 2 1 0 2 2 2 0 Dienelactone hydrolase family PGAP1 PF07819.13 EFA82572.1 - 0.13 12.0 0.7 0.28 10.9 0.6 1.7 1 1 0 1 1 1 0 PGAP1-like protein COesterase PF00135.28 EFA82573.1 - 2.3e-15 56.5 0.1 7.7e-15 54.7 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA82573.1 - 1.4e-12 48.0 0.0 3e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Band_7 PF01145.25 EFA82573.1 - 5.5e-07 29.8 2.2 5.5e-07 29.8 2.2 2.3 2 1 1 3 3 3 1 SPFH domain / Band 7 family Hydrolase_4 PF12146.8 EFA82573.1 - 5.6e-07 29.1 0.8 0.0029 16.9 0.1 3.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 DUF1749 PF08538.10 EFA82573.1 - 8.8e-05 21.7 0.6 0.00024 20.3 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) Say1_Mug180 PF10340.9 EFA82573.1 - 0.00034 19.6 0.1 0.0011 17.9 0.1 1.8 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EFA82573.1 - 0.00084 18.9 0.1 0.0017 17.9 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF915 PF06028.11 EFA82573.1 - 0.0048 16.3 0.4 0.0048 16.3 0.4 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Band_7_1 PF13421.6 EFA82573.1 - 0.013 15.3 0.3 0.043 13.5 0.3 1.9 2 0 0 2 2 2 0 SPFH domain-Band 7 family Abhydrolase_1 PF00561.20 EFA82573.1 - 0.015 15.0 0.4 0.032 13.9 0.4 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA82573.1 - 0.023 15.3 0.0 0.041 14.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EFA82573.1 - 0.04 14.0 0.5 0.084 13.0 0.0 1.7 2 0 0 2 2 2 0 Thioesterase domain Catalase PF00199.19 EFA82574.1 - 6.8e-196 650.9 0.0 7.9e-196 650.6 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EFA82574.1 - 3.2e-24 84.9 0.0 7.6e-24 83.7 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive TMF_TATA_bd PF12325.8 EFA82575.1 - 3.1e-30 104.7 14.3 3.1e-30 104.7 14.3 8.6 3 2 4 7 7 7 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EFA82575.1 - 2.7e-17 62.5 14.1 2.7e-17 62.5 14.1 12.1 7 3 3 10 10 10 2 TATA element modulatory factor 1 DNA binding EF-hand_6 PF13405.6 EFA82575.1 - 8.2e-15 53.4 2.1 0.0017 18.1 0.0 5.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EFA82575.1 - 1.8e-14 52.1 3.8 0.00014 21.1 0.0 4.1 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFA82575.1 - 1.8e-12 47.5 2.1 4.1e-07 30.3 0.4 4.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA82575.1 - 1.6e-11 43.1 6.5 0.0018 17.7 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFA82575.1 - 0.00043 20.1 3.6 0.69 9.8 0.0 3.9 2 1 1 3 3 3 2 EF-hand domain pair Rtf2 PF04641.12 EFA82576.1 - 1.6e-68 231.0 11.7 2.4e-68 230.4 11.7 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 EFA82576.1 - 0.0014 18.4 0.4 0.0028 17.5 0.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFA82576.1 - 0.0063 16.8 0.4 0.013 15.8 0.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFA82576.1 - 0.021 14.8 0.8 0.039 13.9 0.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFA82576.1 - 0.022 14.7 0.4 0.066 13.3 0.4 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFA82576.1 - 0.087 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA82576.1 - 0.099 12.4 1.3 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 RING-like zinc finger DUF3439 PF11921.8 EFA82576.1 - 0.11 12.4 8.9 0.25 11.3 8.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-C3HC4_2 PF13923.6 EFA82576.1 - 0.31 10.9 3.0 0.24 11.3 0.9 2.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4718 PF15842.5 EFA82576.1 - 0.55 10.0 15.6 1.4 8.7 15.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4718) CPL PF08144.11 EFA82577.1 - 3.5e-16 59.8 0.9 1.2e-12 48.4 0.0 3.7 2 2 0 2 2 2 2 CPL (NUC119) domain SAC3 PF12209.8 EFA82577.1 - 0.0022 18.1 5.5 1.7 8.9 0.1 4.9 3 1 2 5 5 5 1 Leucine permease transcriptional regulator helical domain PUF PF00806.19 EFA82577.1 - 0.0058 16.3 0.2 0.59 9.9 0.1 4.2 5 0 0 5 5 5 1 Pumilio-family RNA binding repeat CDC45 PF02724.14 EFA82577.1 - 0.015 13.7 15.0 0.023 13.0 15.0 1.3 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EFA82577.1 - 0.085 13.0 24.3 0.17 12.0 24.3 1.5 1 0 0 1 1 1 0 YL1 nuclear protein TIG PF01833.24 EFA82578.1 - 1.2e-15 57.3 30.6 2.2e-07 30.9 1.3 6.6 4 1 2 6 6 6 4 IPT/TIG domain Lectin_C PF00059.21 EFA82578.1 - 2.7e-05 24.9 0.1 0.019 15.7 0.1 3.2 3 0 0 3 3 3 2 Lectin C-type domain TIG PF01833.24 EFA82579.1 - 2.7e-07 30.6 15.0 0.00068 19.7 2.8 4.5 4 1 0 4 4 4 3 IPT/TIG domain EGF_2 PF07974.13 EFA82579.1 - 0.00018 21.8 10.0 0.00046 20.5 10.0 1.7 1 0 0 1 1 1 1 EGF-like domain DUF4428 PF14471.6 EFA82579.1 - 0.051 13.5 0.2 0.16 11.9 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Laminin_EGF PF00053.24 EFA82579.1 - 2.5 8.3 9.3 7 6.9 9.3 1.7 1 0 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.13 EFA82580.1 - 1.1e-07 32.1 30.0 0.00054 20.3 10.8 2.8 2 0 0 2 2 2 2 EGF-like domain Laminin_EGF PF00053.24 EFA82580.1 - 0.0041 17.2 25.4 0.22 11.7 7.2 2.5 2 0 0 2 2 2 2 Laminin EGF domain MgpC PF05220.12 EFA82580.1 - 0.046 13.1 2.3 0.093 12.0 0.6 2.2 2 0 0 2 2 2 0 MgpC protein precursor EGF_2 PF07974.13 EFA82581.1 - 0.00014 22.2 10.8 0.00032 21.0 10.8 1.6 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 EFA82581.1 - 0.2 11.8 9.1 0.52 10.5 9.1 1.7 1 0 0 1 1 1 0 Laminin EGF domain EGF_alliinase PF04863.13 EFA82581.1 - 0.29 11.6 8.1 1.9 8.9 6.4 2.5 2 0 0 2 2 2 0 Alliinase EGF-like domain hEGF PF12661.7 EFA82581.1 - 1.5 9.5 5.9 5.8 7.7 5.9 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 EFA82581.1 - 2.9 8.3 10.6 0.38 11.1 5.8 2.0 2 0 0 2 2 2 0 EGF-like domain RhoGEF PF00621.20 EFA82582.1 - 1.1e-47 162.6 6.6 1.1e-47 162.6 6.6 3.8 4 0 0 4 4 4 1 RhoGEF domain IQ PF00612.27 EFA82582.1 - 5.9e-05 22.5 0.5 0.00015 21.3 0.5 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif PH PF00169.29 EFA82582.1 - 0.00011 22.6 0.0 0.00011 22.6 0.0 2.5 2 1 1 3 3 3 1 PH domain IQ_SEC7_PH PF16453.5 EFA82582.1 - 0.00097 19.1 0.1 0.00097 19.1 0.1 2.8 3 0 0 3 3 3 1 PH domain DUF2701 PF10857.8 EFA82582.1 - 0.023 14.7 0.3 0.07 13.2 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) Zip PF02535.22 EFA82582.1 - 0.54 9.4 1.7 1.2 8.3 1.7 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter PepSY_TM_like_2 PF16357.5 EFA82582.1 - 0.76 9.7 4.5 0.25 11.3 0.3 2.3 2 0 0 2 2 2 0 Putative PepSY_TM-like Connexin PF00029.19 EFA82582.1 - 3 7.5 8.9 0.16 11.7 1.8 2.1 2 0 0 2 2 2 0 Connexin Phage_Gp23 PF10669.9 EFA82582.1 - 8 6.8 18.5 0.08 13.3 8.5 2.9 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) Pkinase PF00069.25 EFA82583.1 - 3.8e-20 72.4 4.5 1.3e-19 70.6 4.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82583.1 - 2.4e-09 36.9 0.4 6.4e-09 35.5 0.4 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA82583.1 - 0.00044 19.7 0.0 0.0008 18.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH PF00169.29 EFA82585.1 - 2.4e-09 37.6 11.6 8.1e-06 26.3 1.1 3.4 2 1 0 3 3 3 2 PH domain PH_8 PF15409.6 EFA82585.1 - 9.7e-06 25.8 2.2 0.0032 17.7 0.1 3.4 3 0 0 3 3 3 2 Pleckstrin homology domain Androgen_recep PF02166.16 EFA82585.1 - 0.071 11.9 2.0 0.13 11.0 2.0 1.3 1 0 0 1 1 1 0 Androgen receptor PH_11 PF15413.6 EFA82585.1 - 0.26 11.7 21.1 0.043 14.2 8.5 4.6 3 1 0 3 3 3 0 Pleckstrin homology domain TIG PF01833.24 EFA82586.1 - 5.7e-47 157.7 70.1 8.2e-12 45.0 0.7 13.0 13 0 0 13 13 13 11 IPT/TIG domain DNase_II PF03265.15 EFA82586.1 - 4.4e-35 121.5 2.7 3.4e-34 118.6 2.7 2.3 1 1 0 1 1 1 1 Deoxyribonuclease II Ank_2 PF12796.7 EFA82587.1 - 6.5e-06 26.6 1.7 0.031 14.9 0.3 3.2 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA82587.1 - 1.7e-05 25.0 0.6 4.3 7.8 0.0 5.0 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA82587.1 - 0.00011 22.7 1.1 1.1 9.9 0.0 4.4 3 3 2 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82587.1 - 0.00021 21.4 1.2 5.3 7.9 0.0 5.7 5 1 2 7 7 7 1 Ankyrin repeat DED PF01335.21 EFA82587.1 - 0.099 13.0 0.1 2.9 8.3 0.0 3.2 3 2 0 3 3 3 0 Death effector domain N_BRCA1_IG PF16158.5 EFA82588.1 - 1.5e-28 99.5 0.0 3.2e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 EFA82588.1 - 4.7e-15 55.3 0.1 9.3e-15 54.3 0.1 1.5 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.17 EFA82588.1 - 3.4e-11 42.8 6.3 6.8e-11 41.8 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type PSCyt2 PF07583.11 EFA82588.1 - 8e-05 22.7 0.3 0.00014 21.9 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1549) C1_2 PF03107.16 EFA82588.1 - 0.00091 19.5 7.4 0.0022 18.2 7.4 1.6 1 0 0 1 1 1 1 C1 domain ARF7EP_C PF14949.6 EFA82588.1 - 0.022 15.3 2.0 0.043 14.4 2.0 1.4 1 0 0 1 1 1 0 ARF7 effector protein C-terminus DUF3795 PF12675.7 EFA82588.1 - 1.9 9.0 7.8 4.8 7.7 7.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) VWA_3 PF13768.6 EFA82589.1 - 3.2e-25 88.9 0.0 1.1e-24 87.1 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VIT PF08487.10 EFA82589.1 - 3.5e-25 88.4 0.2 1.1e-24 86.8 0.2 2.0 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EFA82589.1 - 7.3e-15 55.6 1.3 1.2e-14 54.9 0.1 2.0 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA82589.1 - 5.1e-12 46.4 0.1 5.7e-11 43.0 0.0 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EFA82589.1 - 0.00031 20.9 0.3 0.00066 19.8 0.0 1.7 2 0 0 2 2 2 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 EFA82589.1 - 0.0026 17.2 0.0 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CobT_C PF11775.8 EFA82589.1 - 0.0027 17.4 0.0 0.0048 16.6 0.0 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT VWA domain VIT_2 PF13757.6 EFA82589.1 - 0.013 15.3 0.1 0.029 14.2 0.1 1.6 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain CsgE PF10627.9 EFA82589.1 - 0.051 13.8 0.2 0.15 12.3 0.2 1.8 1 0 0 1 1 1 0 Curli assembly protein CsgE DUF2201 PF09967.9 EFA82589.1 - 0.091 12.9 0.0 0.29 11.3 0.0 1.9 1 0 0 1 1 1 0 VWA-like domain (DUF2201) UQ_con PF00179.26 EFA82590.1 - 7.4e-17 61.3 0.1 7.4e-17 61.3 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme CPP1-like PF11833.8 EFA82590.1 - 0.0022 17.7 0.7 0.0038 16.9 0.7 1.3 1 0 0 1 1 1 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like TMEM154 PF15102.6 EFA82590.1 - 0.0059 16.5 0.3 0.0091 15.9 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family OmpH PF03938.14 EFA82590.1 - 0.012 15.9 9.0 0.012 15.9 9.0 1.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ORC_WH_C PF18137.1 EFA82590.1 - 0.026 14.6 0.1 0.042 13.9 0.1 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Orf78 PF06024.12 EFA82590.1 - 0.032 14.5 0.4 0.057 13.7 0.4 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Adhesin_E PF16747.5 EFA82590.1 - 0.2 11.7 1.7 0.37 10.8 1.7 1.5 1 1 0 1 1 1 0 Surface-adhesin protein E DUF4199 PF13858.6 EFA82590.1 - 0.32 11.4 2.5 0.35 11.3 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Androgen_recep PF02166.16 EFA82590.1 - 1 8.1 8.7 1.4 7.7 8.7 1.1 1 0 0 1 1 1 0 Androgen receptor Ank_2 PF12796.7 EFA82591.1 - 3.6e-60 200.5 5.1 7.6e-15 55.3 0.0 4.7 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) GDPD PF03009.17 EFA82591.1 - 7.1e-55 186.5 0.0 1.5e-54 185.4 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_4 PF13637.6 EFA82591.1 - 4e-39 132.5 0.9 1.8e-08 34.7 0.0 6.5 2 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA82591.1 - 1.9e-26 91.8 0.2 0.00042 20.6 0.0 6.8 3 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82591.1 - 3.4e-25 85.3 2.7 0.079 13.6 0.0 8.9 8 0 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 EFA82591.1 - 7.1e-23 80.0 0.0 0.0072 16.7 0.0 7.2 6 0 0 6 6 6 6 Ankyrin repeat CBM_20 PF00686.19 EFA82591.1 - 3.3e-17 62.2 0.0 1.1e-16 60.5 0.0 1.9 1 0 0 1 1 1 1 Starch binding domain SPX PF03105.19 EFA82591.1 - 0.0013 18.7 14.5 0.032 14.1 0.0 4.3 4 1 1 5 5 5 2 SPX domain PRP3 PF08572.10 EFA82592.1 - 0.0003 20.6 2.0 0.00035 20.4 2.0 1.1 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF2722 PF10846.8 EFA82592.1 - 0.00075 18.6 0.9 0.00075 18.6 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Gaa1 PF04114.14 EFA82592.1 - 0.02 13.9 0.1 0.036 13.1 0.1 1.3 1 1 0 1 1 1 0 Gaa1-like, GPI transamidase component Agenet PF05641.12 EFA82592.1 - 0.038 14.5 1.6 0.68 10.4 0.9 2.4 2 1 0 2 2 2 0 Agenet domain MMgT PF10270.9 EFA82592.1 - 0.057 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Membrane magnesium transporter Dimer_Tnp_hAT PF05699.14 EFA82593.1 - 1.9e-10 40.4 0.3 6.5e-10 38.7 0.3 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF1360 PF07098.11 EFA82594.1 - 0.15 12.0 2.7 0.25 11.3 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) SET PF00856.28 EFA82595.1 - 5.3e-16 59.5 0.1 1.6e-15 57.9 0.1 1.8 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.17 EFA82595.1 - 7.9e-07 28.7 0.1 0.17 12.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA82595.1 - 1.7e-05 24.4 0.5 0.07 13.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA82595.1 - 0.00022 21.2 0.0 0.041 14.1 0.0 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA82595.1 - 0.00076 20.1 0.0 0.0064 17.1 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat zf-MYND PF01753.18 EFA82595.1 - 0.0014 18.7 4.3 0.0016 18.5 1.0 2.6 2 0 0 2 2 2 1 MYND finger GlcV_C_terminal PF17847.1 EFA82595.1 - 0.051 14.0 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Glucose ABC transporter C-terminal domain FKS1_dom1 PF14288.6 EFA82595.1 - 0.058 13.7 0.1 0.15 12.4 0.1 1.8 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 TPR_11 PF13414.6 EFA82595.1 - 0.15 11.8 0.2 7.8 6.3 0.2 3.0 3 0 0 3 3 3 0 TPR repeat TPR_14 PF13428.6 EFA82595.1 - 0.16 12.8 0.0 8.5 7.5 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA82595.1 - 0.17 12.4 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 EFA82596.1 - 4.2e-12 44.7 3.3 4.5e-05 22.7 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFA82596.1 - 4e-10 40.0 1.0 5.6e-10 39.5 0.3 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFA82596.1 - 4.7e-09 35.5 1.3 1.2e-05 24.9 0.2 2.5 1 1 1 2 2 2 2 EF-hand domain EF-hand_9 PF14658.6 EFA82596.1 - 0.00084 19.6 0.3 0.0014 18.9 0.0 1.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EFA82596.1 - 0.0015 18.3 0.7 0.0035 17.2 0.7 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFA82596.1 - 0.0064 15.9 2.1 0.1 12.2 0.1 2.7 3 0 0 3 3 3 1 EF hand Dockerin_1 PF00404.18 EFA82596.1 - 0.028 14.6 0.4 0.15 12.3 0.4 2.2 1 1 0 1 1 1 0 Dockerin type I domain Glyco_hydro_7 PF00840.20 EFA82597.1 - 4.5e-148 493.6 14.0 5e-148 493.4 14.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 PAS_8 PF13188.7 EFA82597.1 - 0.098 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 PAS domain Kinesin PF00225.23 EFA82598.1 - 5.8e-101 337.7 1.9 5.8e-101 337.7 1.9 4.1 4 1 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EFA82598.1 - 7.9e-20 71.3 0.2 7.9e-20 71.3 0.2 3.9 3 2 0 3 3 3 1 Microtubule binding WD40 PF00400.32 EFA82598.1 - 2.3e-17 63.0 11.4 7.4e-05 23.4 0.3 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat TPR_17 PF13431.6 EFA82599.1 - 8.6e-137 436.1 17.4 1.6e-10 40.6 0.0 15.1 14 1 1 15 15 15 14 Tetratricopeptide repeat TPR_11 PF13414.6 EFA82599.1 - 5e-22 77.3 23.9 0.047 13.4 0.0 13.8 15 0 0 15 15 15 9 TPR repeat DUF1153 PF06627.11 EFA82599.1 - 2.1e-06 27.8 0.3 91 3.3 0.0 9.2 12 0 0 12 12 12 0 Protein of unknown function (DUF1153) Anth_Ig PF05587.13 EFA82599.1 - 2.3e-06 27.8 13.2 15 5.9 0.0 10.5 12 0 0 12 12 12 1 Anthrax receptor extracellular domain preSET_CXC PF18264.1 EFA82599.1 - 0.0006 20.2 8.0 32 5.1 0.0 9.4 12 0 0 12 12 12 0 CXC domain PT-HINT PF07591.11 EFA82599.1 - 0.015 15.5 0.0 1 9.6 0.0 3.1 3 0 0 3 3 3 0 Pretoxin HINT domain UME PF08064.13 EFA82599.1 - 0.071 13.0 3.8 2.6 8.0 0.0 5.4 8 2 1 9 9 9 0 UME (NUC010) domain TPR_2 PF07719.17 EFA82599.1 - 0.26 11.5 11.0 6 7.2 0.1 8.2 11 0 0 11 11 11 0 Tetratricopeptide repeat SFTA2 PF15210.6 EFA82599.1 - 0.57 10.2 7.3 21 5.1 0.1 5.5 6 0 0 6 6 6 0 Surfactant-associated protein 2 E3_UbLigase_R4 PF13764.6 EFA82601.1 - 0 1030.9 1.2 0 1030.9 1.2 3.2 3 1 1 4 4 4 2 E3 ubiquitin-protein ligase UBR4 ZZ PF00569.17 EFA82601.1 - 2.4e-11 43.3 5.9 2.4e-11 43.3 5.9 3.7 2 1 0 2 2 2 1 Zinc finger, ZZ type UIM PF02809.20 EFA82601.1 - 0.0085 15.9 1.7 0.027 14.4 1.7 1.9 1 0 0 1 1 1 1 Ubiquitin interaction motif Suv3_N PF18114.1 EFA82601.1 - 0.078 13.1 1.1 0.46 10.6 1.1 2.4 1 0 0 1 1 1 0 Suv3 helical N-terminal domain ARL2_Bind_BART PF11527.8 EFA82601.1 - 6 7.0 7.5 18 5.5 0.4 4.3 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART MAD PF05557.13 EFA82602.1 - 1.7e-52 178.8 78.4 7.7e-37 127.0 2.9 3.2 2 1 1 3 3 3 2 Mitotic checkpoint protein MscS_porin PF12795.7 EFA82602.1 - 0.00026 20.6 3.8 0.00026 20.6 3.8 4.5 3 1 1 4 4 4 2 Mechanosensitive ion channel porin domain Arteri_nucleo PF01481.16 EFA82602.1 - 0.25 11.7 2.2 12 6.2 0.0 3.7 4 0 0 4 4 4 0 Arterivirus nucleocapsid protein TrbI_Ftype PF09677.10 EFA82602.1 - 0.93 9.8 3.2 1.7 9.0 0.1 2.9 3 0 0 3 3 3 0 Type-F conjugative transfer system protein (TrbI_Ftype) TPR_MLP1_2 PF07926.12 EFA82602.1 - 2.9 8.0 74.6 0.023 14.8 5.7 7.4 2 1 5 7 7 7 0 TPR/MLP1/MLP2-like protein PNP_UDP_1 PF01048.20 EFA82603.1 - 3.1e-30 105.1 0.1 3.7e-30 104.9 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily ERCC4 PF02732.15 EFA82604.1 - 1.8e-13 51.0 2.9 7.1e-13 49.1 0.0 3.4 4 0 0 4 4 4 1 ERCC4 domain MCM_bind PF09739.9 EFA82604.1 - 0.12 10.9 18.9 0.1 11.0 0.1 2.2 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor CRM1_repeat_2 PF18784.1 EFA82604.1 - 0.15 11.7 0.6 0.41 10.3 0.1 2.0 2 0 0 2 2 2 0 CRM1 / Exportin repeat 2 RPOL_N PF14700.6 EFA82604.1 - 7.5 5.8 15.9 0.041 13.3 4.7 2.6 3 0 0 3 3 3 0 DNA-directed RNA polymerase N-terminal LRR_4 PF12799.7 EFA82606.1 - 3.7e-32 109.8 48.2 9.3e-08 32.3 1.2 7.3 5 2 0 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA82606.1 - 8e-28 96.0 38.0 2.2e-10 40.2 0.8 5.6 2 1 4 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 EFA82606.1 - 7.1e-21 74.5 25.5 1.6e-08 34.3 2.1 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 EFA82606.1 - 4.3e-06 26.3 26.2 0.042 13.9 0.4 8.2 9 0 0 9 9 9 2 Leucine Rich repeat Ploopntkinase2 PF18747.1 EFA82606.1 - 0.07 12.4 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase2 LRR_2 PF07723.13 EFA82606.1 - 0.23 12.2 0.8 80 4.1 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_1 PF00560.33 EFA82606.1 - 2.1 9.2 38.6 5.5 7.9 0.1 10.4 12 1 0 12 12 12 0 Leucine Rich Repeat E2F_TDP PF02319.20 EFA82607.1 - 1.9e-16 59.8 0.5 5.1e-07 29.7 0.0 2.6 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain DUF2981 PF11200.8 EFA82609.1 - 0.16 11.7 2.5 0.17 11.6 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Vps51 PF08700.11 EFA82610.1 - 5.9e-12 45.5 3.0 5.9e-12 45.5 3.0 2.8 2 0 0 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 EFA82610.1 - 0.019 15.2 2.1 0.019 15.2 2.1 5.1 7 1 0 7 7 7 0 Golgi transport complex subunit 5 AKNA PF12443.8 EFA82610.1 - 0.083 13.5 3.7 0.78 10.4 0.5 3.2 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF1664 PF07889.12 EFA82610.1 - 1.1 9.3 5.1 3.8 7.6 1.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) LCM PF04072.14 EFA82611.1 - 1.1e-33 116.7 0.0 1.8e-33 116.1 0.0 1.4 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase LCM PF04072.14 EFA82612.1 - 1e-67 227.7 0.0 1.2e-32 113.3 0.0 2.4 2 1 0 2 2 2 2 Leucine carboxyl methyltransferase HTH_27 PF13463.6 EFA82612.1 - 0.092 13.2 0.0 7.3 7.2 0.0 2.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain ProRS-C_2 PF09181.10 EFA82612.1 - 0.21 11.7 2.9 10 6.3 0.1 2.9 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Spt46 PF17734.1 EFA82612.1 - 0.27 11.0 2.1 17 5.1 0.2 2.4 2 0 0 2 2 2 0 Spermatogenesis-associated protein 46 DUF4767 PF15983.5 EFA82612.1 - 0.39 11.0 3.0 19 5.5 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4767) IF2_N PF04760.15 EFA82612.1 - 1.7 8.5 6.4 36 4.3 0.2 4.4 4 0 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region Proteasome PF00227.26 EFA82613.1 - 8.2e-57 191.8 0.0 1.9e-56 190.6 0.0 1.5 1 1 1 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA82613.1 - 2.6e-09 36.6 0.1 1.7e-08 34.0 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature YozE_SAM_like PF06855.12 EFA82615.1 - 0.067 13.4 0.5 0.25 11.6 0.0 2.2 3 0 0 3 3 3 0 YozE SAM-like fold SPAN PF02510.14 EFA82615.1 - 0.15 11.2 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Surface presentation of antigens protein Glyco_hydro_18 PF00704.28 EFA82616.1 - 1.5e-63 215.5 0.2 2e-63 215.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_C54 PF03416.19 EFA82617.1 - 1.5e-44 152.5 1.7 3.3e-27 95.6 1.0 3.8 1 1 1 2 2 2 2 Peptidase family C54 DUF4279 PF14106.6 EFA82617.1 - 0.048 13.9 0.1 5.3 7.3 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) Mucin PF01456.17 EFA82617.1 - 0.25 11.3 5.8 0.058 13.4 0.9 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein TBCA PF02970.16 EFA82617.1 - 2.4 8.6 6.3 0.48 10.8 0.2 2.8 3 0 0 3 3 3 0 Tubulin binding cofactor A HeLo PF14479.6 EFA82617.1 - 8 6.2 11.3 0.16 11.8 3.1 2.2 2 1 0 2 2 2 0 Prion-inhibition and propagation Ribosomal_L9_N PF01281.19 EFA82618.1 - 1.3e-15 56.7 0.0 2.1e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 EFA82618.1 - 0.00011 22.5 0.2 0.00022 21.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, C-terminal domain ABA_GPCR PF12430.8 EFA82619.1 - 2.5e-19 69.7 5.1 2.8e-19 69.6 5.1 1.0 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor RICTOR_V PF14668.6 EFA82620.1 - 0.0016 18.7 0.4 0.0034 17.6 0.4 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 SLAC1 PF03595.17 EFA82620.1 - 0.0085 15.4 9.0 0.0095 15.2 9.0 1.2 1 0 0 1 1 1 1 Voltage-dependent anion channel Tmpp129 PF10272.9 EFA82620.1 - 0.055 12.8 4.3 0.072 12.4 4.3 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor TssN PF17555.2 EFA82620.1 - 0.24 10.8 14.0 0.3 10.5 14.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN Rhodanese PF00581.20 EFA82621.1 - 2.2e-15 57.1 0.0 7.2e-15 55.4 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain Draxin PF15550.6 EFA82622.1 - 0.012 15.5 6.6 0.02 14.7 6.6 1.3 1 0 0 1 1 1 0 Draxin Ndc1_Nup PF09531.10 EFA82622.1 - 0.058 12.1 5.6 0.084 11.5 5.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Atg8 PF02991.16 EFA82622.1 - 0.093 12.9 0.1 0.39 10.9 0.0 2.1 1 1 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like Menin PF05053.13 EFA82622.1 - 0.36 9.1 8.1 0.51 8.6 8.1 1.1 1 0 0 1 1 1 0 Menin FSA_C PF10479.9 EFA82622.1 - 0.98 7.5 13.4 1.5 6.9 13.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus NST1 PF13945.6 EFA82622.1 - 1.7 8.7 18.2 3.8 7.6 18.2 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF3439 PF11921.8 EFA82622.1 - 4.9 7.2 12.3 9.8 6.2 12.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ATP_bind_1 PF03029.17 EFA82623.1 - 0.031 14.1 0.6 0.049 13.4 0.6 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Ank_2 PF12796.7 EFA82623.1 - 0.085 13.5 0.2 0.6 10.7 0.0 2.4 3 1 0 3 3 3 0 Ankyrin repeats (3 copies) LolB PF03550.14 EFA82623.1 - 0.15 12.1 0.0 1.4 9.0 0.0 2.1 2 0 0 2 2 2 0 Outer membrane lipoprotein LolB DUF3447 PF11929.8 EFA82624.1 - 0.0001 22.2 0.1 0.0033 17.3 0.1 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3447) TIM PF00121.18 EFA82625.1 - 1.2e-88 296.7 0.3 1.3e-88 296.5 0.3 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Qua1 PF16274.5 EFA82626.1 - 0.039 13.8 1.9 0.082 12.8 0.7 2.2 2 0 0 2 2 2 0 Qua1 domain DUF4790 PF16037.5 EFA82626.1 - 0.043 14.3 1.9 0.085 13.3 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4790) TIG PF01833.24 EFA82627.1 - 6.1e-156 506.9 389.2 2.1e-13 50.1 5.9 30.3 28 2 0 29 29 29 26 IPT/TIG domain Qn_am_d_aIII PF09099.10 EFA82627.1 - 8.6e-06 26.1 24.6 0.29 11.5 0.1 12.1 14 0 0 14 14 14 3 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Arf PF00025.21 EFA82627.1 - 0.0016 17.9 0.0 0.0035 16.8 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family FlbT PF07378.11 EFA82627.1 - 1.3 9.1 4.4 89 3.2 0.2 3.5 3 0 0 3 3 3 0 Flagellar protein FlbT SdrD_B PF17210.3 EFA82628.1 - 3.7e-05 23.9 0.4 0.0049 17.1 0.1 3.0 2 0 0 2 2 2 2 SdrD B-like domain DiSB-ORF2_chro PF16506.5 EFA82628.1 - 0.13 12.3 0.5 49 4.0 0.1 3.5 3 0 0 3 3 3 0 Putative virion glycoprotein of insect viruses DUF2380 PF09533.10 EFA82630.1 - 0.023 14.3 0.4 0.061 13.0 0.0 1.8 2 0 0 2 2 2 0 Predicted lipoprotein of unknown function (DUF2380) F-box-like PF12937.7 EFA82630.1 - 2.2 8.2 6.5 9.4 6.2 4.3 3.1 2 1 0 2 2 2 0 F-box-like Kelch_5 PF13854.6 EFA82631.1 - 2.1e-14 53.1 8.9 1.2e-05 25.2 0.0 5.7 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EFA82631.1 - 9.3e-14 50.7 8.5 2.4e-06 27.0 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EFA82631.1 - 1.4e-12 47.4 10.8 7.2e-06 26.1 0.0 5.1 5 1 1 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EFA82631.1 - 2.7e-12 46.5 12.7 1e-05 25.4 0.0 6.1 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA82631.1 - 2.4e-09 37.2 9.5 4.3e-08 33.2 0.1 5.4 4 1 0 4 4 4 1 Galactose oxidase, central domain F-box-like PF12937.7 EFA82631.1 - 2.6e-07 30.4 3.1 6.1e-07 29.2 3.1 1.6 1 0 0 1 1 1 1 F-box-like Kelch_2 PF07646.15 EFA82631.1 - 3.6e-07 29.9 9.6 0.0083 16.1 0.0 5.3 5 1 0 5 5 5 2 Kelch motif Spt20 PF12090.8 EFA82631.1 - 0.0002 21.1 17.6 0.0002 21.1 17.6 3.1 2 1 0 2 2 1 1 Spt20 family TFIIA PF03153.13 EFA82631.1 - 0.00046 20.3 10.6 0.00046 20.3 10.6 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit F-box PF00646.33 EFA82631.1 - 0.0032 17.3 2.7 0.0076 16.1 2.7 1.7 1 0 0 1 1 1 1 F-box domain DUF4770 PF15994.5 EFA82631.1 - 0.0067 16.7 3.0 0.0067 16.7 3.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4770) DUF4746 PF15928.5 EFA82631.1 - 0.011 15.2 2.3 0.018 14.5 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CSG2 PF16965.5 EFA82631.1 - 0.17 10.8 1.9 0.38 9.6 1.9 1.5 1 0 0 1 1 1 0 Ceramide synthase regulator TMEM51 PF15345.6 EFA82631.1 - 0.29 10.9 10.0 0.75 9.6 10.0 1.6 1 0 0 1 1 1 0 Transmembrane protein 51 RP-C_C PF11800.8 EFA82631.1 - 1.4 9.0 11.9 0.97 9.5 5.4 2.5 3 0 0 3 3 3 0 Replication protein C C-terminal region CLN3 PF02487.17 EFA82631.1 - 1.6 7.7 7.1 0.2 10.7 2.9 1.6 2 0 0 2 2 2 0 CLN3 protein ORC_WH_C PF18137.1 EFA82631.1 - 2.1 8.4 11.5 1.2 9.2 3.9 2.3 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Neur_chan_memb PF02932.16 EFA82631.1 - 6.3 6.8 8.6 0.46 10.5 2.0 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 EFA82631.1 - 9.7 4.9 12.4 0.075 11.9 2.5 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Glycos_transf_1 PF00534.20 EFA82633.1 - 8.2e-23 80.8 0.1 1.8e-22 79.7 0.1 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 EFA82633.1 - 4.4e-22 79.2 0.0 9.4e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glyco_trans_1_4 PF13692.6 EFA82633.1 - 5.9e-14 52.7 0.0 1.1e-13 51.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFA82633.1 - 0.00014 22.2 0.4 0.00051 20.4 0.1 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF1129 PF06570.11 EFA82633.1 - 0.0029 17.1 6.0 0.0086 15.6 6.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) Glyco_tran_WecB PF03808.13 EFA82633.1 - 0.19 11.7 0.3 9.1 6.2 0.0 2.7 3 0 0 3 3 3 0 Glycosyl transferase WecB/TagA/CpsF family Clc-like PF07062.12 EFA82633.1 - 0.33 10.4 3.7 0.58 9.6 3.7 1.3 1 0 0 1 1 1 0 Clc-like DUF2207 PF09972.9 EFA82633.1 - 9.4 4.9 11.9 14 4.3 9.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ank_4 PF13637.6 EFA82634.1 - 0.027 15.1 0.0 0.038 14.6 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82634.1 - 0.11 13.1 0.0 0.28 11.9 0.0 1.7 2 0 0 2 2 2 0 Ankyrin repeat TIG PF01833.24 EFA82635.1 - 5e-45 151.5 67.9 1.4e-12 47.5 1.2 12.6 13 1 1 14 14 14 8 IPT/TIG domain DNase_II PF03265.15 EFA82635.1 - 4e-34 118.4 4.4 5.6e-33 114.6 4.4 2.5 1 1 0 1 1 1 1 Deoxyribonuclease II DnaJ PF00226.31 EFA82636.1 - 0.00057 20.0 0.0 0.0019 18.3 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain SMC_hinge PF06470.13 EFA82636.1 - 0.061 13.6 0.0 0.24 11.7 0.0 2.1 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain MATH PF00917.26 EFA82638.1 - 5.2e-16 58.8 0.6 9.7e-16 57.9 0.6 1.4 1 0 0 1 1 1 1 MATH domain USP7_ICP0_bdg PF12436.8 EFA82639.1 - 3.6e-63 213.1 2.5 6.5e-63 212.2 2.5 1.4 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EFA82639.1 - 5.4e-52 176.5 4.0 8e-52 175.9 0.8 2.8 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 EFA82639.1 - 9.4e-34 117.1 0.6 2.7e-33 115.5 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA82639.1 - 6.9e-12 45.6 0.0 2.8e-11 43.6 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFA82639.1 - 0.0062 16.3 1.4 26 4.7 0.0 4.5 5 0 0 5 5 5 2 Ubiquitin family YukD PF08817.10 EFA82639.1 - 0.096 13.4 0.0 0.27 12.0 0.0 1.8 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD SdrD_B PF17210.3 EFA82640.1 - 0.0013 18.9 0.0 0.0045 17.2 0.0 2.0 1 0 0 1 1 1 1 SdrD B-like domain TIG PF01833.24 EFA82641.1 - 6.8e-183 593.3 452.3 2.1e-13 50.2 6.0 33.8 31 2 0 32 32 32 30 IPT/TIG domain Qn_am_d_aIII PF09099.10 EFA82641.1 - 0.00011 22.5 27.5 4 7.9 0.1 14.0 17 0 0 17 17 17 2 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Ras PF00071.22 EFA82642.1 - 2.8e-39 134.3 0.3 9e-39 132.7 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFA82642.1 - 3.8e-20 72.3 0.0 1.2e-19 70.7 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82642.1 - 8.1e-11 41.7 0.6 1.8e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.18 EFA82642.1 - 1.4e-06 27.9 0.0 5.3e-06 26.1 0.0 2.0 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFA82642.1 - 0.0022 18.1 0.0 0.016 15.2 0.0 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-B_box PF00643.24 EFA82642.1 - 0.02 15.1 12.9 0.034 14.3 12.9 1.4 1 0 0 1 1 1 0 B-box zinc finger zf-UBP PF02148.19 EFA82642.1 - 0.43 11.0 5.8 1.2 9.5 5.8 1.8 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein PYST-C1 PF09690.10 EFA82643.1 - 0.057 13.2 1.5 0.076 12.8 1.5 1.3 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) Coiled PF05710.12 EFA82643.1 - 0.32 11.9 5.1 0.44 11.4 5.1 1.2 1 0 0 1 1 1 0 Coiled coil Ras PF00071.22 EFA82644.1 - 1.3e-38 132.1 0.1 3.6e-38 130.7 0.1 1.8 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82644.1 - 3.5e-21 75.6 1.7 4.2e-21 75.4 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82644.1 - 2.8e-10 39.9 0.0 7.7e-10 38.5 0.0 1.7 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA82644.1 - 0.0018 18.2 1.3 1.1 9.1 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase zf-B_box PF00643.24 EFA82644.1 - 0.044 13.9 13.1 0.079 13.1 13.1 1.4 1 0 0 1 1 1 0 B-box zinc finger Vps53_N PF04100.12 EFA82645.1 - 0.011 14.8 0.1 0.011 14.8 0.1 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal PYST-C1 PF09690.10 EFA82645.1 - 0.033 13.9 2.0 0.046 13.5 2.0 1.2 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) UBX PF00789.20 EFA82647.1 - 2.9e-13 49.8 0.0 5.6e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EFA82647.1 - 4.7e-10 39.1 0.3 1e-09 38.0 0.3 1.6 1 0 0 1 1 1 1 UBA-like domain Serglycin PF04360.12 EFA82647.1 - 0.014 15.4 1.1 0.025 14.6 1.1 1.4 1 0 0 1 1 1 0 Serglycin TAP_C PF03943.13 EFA82647.1 - 0.072 12.7 0.1 0.21 11.3 0.1 1.7 1 0 0 1 1 1 0 TAP C-terminal domain DUF4746 PF15928.5 EFA82647.1 - 1.3 8.4 8.5 2.8 7.3 8.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MatB PF16449.5 EFA82648.1 - 0.092 12.5 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Fimbrillin MatB CH PF00307.31 EFA82649.1 - 1.2e-83 276.5 1.4 8.1e-21 74.2 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.32 EFA82649.1 - 2.7e-14 51.6 0.4 8.5e-06 25.0 0.5 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFA82649.1 - 1.7e-11 44.4 0.2 5.8e-11 42.7 0.1 2.0 2 0 0 2 2 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFA82649.1 - 3.6e-11 42.0 1.3 9.5e-06 24.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFA82649.1 - 4.6e-11 42.4 0.6 1.7e-10 40.5 0.4 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA82649.1 - 1.5e-10 40.1 0.2 1.5e-05 24.6 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain CAMSAP_CH PF11971.8 EFA82649.1 - 0.004 16.9 0.0 2.6 7.9 0.0 3.3 4 0 0 4 4 4 1 CAMSAP CH domain SPARC_Ca_bdg PF10591.9 EFA82649.1 - 0.019 15.2 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFA82649.1 - 0.058 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_4 PF12763.7 EFA82649.1 - 0.092 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand CH_2 PF06294.11 EFA82649.1 - 0.13 12.4 0.0 11 6.2 0.0 2.9 3 0 0 3 3 3 0 CH-like domain in sperm protein CBM49 PF09478.10 EFA82651.1 - 1.1e-15 57.7 0.1 3.8e-15 56.0 0.1 1.9 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 AAA PF00004.29 EFA82651.1 - 0.0019 18.7 0.0 0.0034 17.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PikAIV_N PF18605.1 EFA82652.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Ank_4 PF13637.6 EFA82653.1 - 1.2e-21 76.7 6.8 1.4e-05 25.6 0.1 8.5 7 1 1 8 8 8 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA82653.1 - 2.7e-20 72.7 5.7 5.7e-07 30.0 0.1 5.9 2 2 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA82653.1 - 2.5e-10 40.4 2.8 0.22 11.9 0.0 7.0 5 1 4 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82653.1 - 3.6e-09 36.1 4.6 14 6.7 0.0 10.4 12 1 1 13 13 13 1 Ankyrin repeat Rbsn PF11464.8 EFA82653.1 - 0.37 10.5 1.9 5.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Rabenosyn Rab binding domain CBM49 PF09478.10 EFA82654.1 - 1.4e-16 60.5 0.1 1.9e-16 60.1 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 HEAT PF02985.22 EFA82655.1 - 0.0024 18.0 0.4 1.4 9.3 0.0 4.0 4 0 0 4 4 4 2 HEAT repeat RL10P_insert PF17777.1 EFA82656.1 - 1.7e-18 66.3 0.0 2.6e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EFA82656.1 - 5.1e-14 52.2 0.0 8.1e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Skp1 PF01466.19 EFA82657.1 - 1e-29 102.3 1.5 1e-29 102.3 1.5 1.8 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EFA82657.1 - 1.5e-25 89.1 3.2 3.7e-24 84.7 2.0 2.8 2 1 0 2 2 2 1 Skp1 family, tetramerisation domain DUF3135 PF11333.8 EFA82658.1 - 0.16 12.2 0.1 2.9 8.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) DUF4211 PF13926.6 EFA82659.1 - 8e-31 107.0 1.1 8e-31 107.0 1.1 4.2 5 0 0 5 5 5 1 Domain of unknown function (DUF4211) BUD22 PF09073.10 EFA82659.1 - 0.0035 16.8 22.5 0.0035 16.8 22.5 6.0 4 2 1 5 5 5 1 BUD22 FNIP PF05725.12 EFA82660.1 - 5e-13 49.0 36.5 8.2e-06 25.9 0.7 7.4 6 1 0 7 7 7 5 FNIP Repeat Sacchrp_dh_C PF16653.5 EFA82660.1 - 0.023 14.8 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain RepA1_leader PF08048.12 EFA82662.1 - 0.075 13.3 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 Tap RepA1 leader peptide Y_Y_Y PF07495.13 EFA82662.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Y_Y_Y domain Ank_2 PF12796.7 EFA82663.1 - 7e-21 74.6 10.3 2.7e-08 34.3 0.7 5.2 2 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82663.1 - 1.7e-16 60.3 11.5 0.00026 21.5 0.1 6.8 4 3 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82663.1 - 9e-15 53.3 5.6 2.3 9.0 0.0 9.0 8 1 1 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EFA82663.1 - 1.6e-13 50.5 12.2 0.018 15.4 0.1 8.5 3 3 7 10 10 10 4 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA82663.1 - 2.7e-06 27.2 2.8 0.26 11.2 0.0 4.9 3 1 2 5 5 5 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA82663.1 - 0.0047 17.3 5.3 64 4.3 0.0 6.0 4 1 2 6 6 6 0 Ankyrin repeat RhoGEF PF00621.20 EFA82665.1 - 7.1e-33 114.4 0.2 7.1e-33 114.4 0.2 2.8 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EFA82665.1 - 4.6e-06 27.1 0.1 1.8e-05 25.2 0.1 2.1 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 EFA82665.1 - 0.0019 18.1 0.0 0.0063 16.4 0.0 1.9 2 0 0 2 2 2 1 PH domain IQ PF00612.27 EFA82665.1 - 0.0045 16.7 2.8 0.01 15.6 2.8 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif PH_13 PF16652.5 EFA82665.1 - 0.005 16.7 0.5 0.005 16.7 0.5 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain Remorin_C PF03763.13 EFA82665.1 - 2 8.3 8.0 0.3 11.0 3.4 2.0 2 0 0 2 2 2 0 Remorin, C-terminal region YjeF_N PF03853.15 EFA82667.1 - 6.6e-35 120.5 0.0 9.7e-35 120.0 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus Trypsin_2 PF13365.6 EFA82668.1 - 1.2e-33 117.2 0.0 2.7e-20 73.8 0.2 2.7 2 1 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.26 EFA82668.1 - 1.1e-06 28.6 3.6 1.9e-05 24.6 0.5 3.7 3 2 0 3 3 3 1 Trypsin Peptidase_S46 PF10459.9 EFA82668.1 - 0.00028 19.7 2.4 0.4 9.3 0.0 3.1 3 0 0 3 3 3 3 Peptidase S46 FNIP PF05725.12 EFA82669.1 - 2.1e-17 63.0 27.4 4.2e-11 42.8 0.1 7.8 7 1 2 9 9 9 4 FNIP Repeat F-box-like PF12937.7 EFA82669.1 - 0.021 14.7 1.4 0.041 13.8 0.3 2.1 2 0 0 2 2 2 0 F-box-like F-box_5 PF18511.1 EFA82669.1 - 0.034 13.7 0.1 0.081 12.5 0.1 1.6 1 0 0 1 1 1 0 F-box SapB_2 PF03489.17 EFA82670.1 - 3e-57 190.4 24.9 5.6e-12 45.6 0.8 6.0 5 0 0 5 5 5 5 Saposin-like type B, region 2 SapB_1 PF05184.15 EFA82670.1 - 2.6e-45 151.9 32.4 2.8e-10 40.0 0.9 6.3 6 0 0 6 6 6 5 Saposin-like type B, region 1 A_thal_3526 PF09713.10 EFA82670.1 - 0.00042 20.5 2.9 2 8.7 0.1 4.8 5 0 0 5 5 5 1 Plant protein 1589 of unknown function (A_thal_3526) B5 PF03484.15 EFA82670.1 - 0.097 13.0 0.2 8.7 6.7 0.0 3.3 3 0 0 3 3 3 0 tRNA synthetase B5 domain Prion_bPrPp PF11587.8 EFA82670.1 - 0.17 11.7 19.8 1.4 8.8 0.6 5.3 5 0 0 5 5 5 0 Major prion protein bPrPp - N terminal Picorna_P3A PF06363.11 EFA82670.1 - 0.46 10.4 3.7 5.9 6.8 0.0 4.0 5 0 0 5 5 5 0 Picornaviridae P3A protein RNA_POL_M_15KD PF02150.16 EFA82670.1 - 2.8 7.9 13.3 13 5.7 0.1 5.0 5 0 0 5 5 5 0 RNA polymerases M/15 Kd subunit CBM49 PF09478.10 EFA82672.1 - 3.3e-05 24.1 0.5 6.4e-05 23.2 0.5 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Band_7 PF01145.25 EFA82673.1 - 1.9e-06 28.0 0.9 1.9e-06 28.0 0.9 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EFA82673.1 - 0.0031 17.3 0.1 0.0053 16.5 0.1 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family DUF4407 PF14362.6 EFA82673.1 - 1.7 7.9 11.7 2.9 7.2 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V-ATPase_G_2 PF16999.5 EFA82673.1 - 4.5 7.7 13.7 1.7 9.1 10.2 2.1 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit SH3_1 PF00018.28 EFA82674.1 - 1.5e-19 69.4 0.3 4.5e-11 42.2 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EFA82674.1 - 1.6e-19 69.3 0.0 1.8e-11 43.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 EFA82674.1 - 2.1e-19 69.1 0.0 7.8e-09 35.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain AMP-binding PF00501.28 EFA82675.1 - 3.1e-78 263.3 0.0 4.1e-78 262.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA82675.1 - 1.9e-22 80.0 0.1 3.7e-22 79.1 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EFA82675.1 - 1.3e-15 57.0 2.4 2.3e-15 56.2 2.4 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Tau95 PF09734.9 EFA82677.1 - 4.4e-30 105.3 0.3 4.4e-30 105.3 0.3 4.2 4 1 0 4 4 4 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EFA82677.1 - 4.1e-24 85.2 9.4 4.1e-24 85.2 9.4 4.1 3 2 0 3 3 3 1 Tau95 Triple barrel domain DUF4320 PF14208.6 EFA82677.1 - 0.14 12.2 2.9 0.89 9.6 2.9 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) SR-25 PF10500.9 EFA82677.1 - 2.8 7.5 48.2 0.098 12.3 11.0 4.2 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein RRM_1 PF00076.22 EFA82678.1 - 8.4e-29 99.2 0.4 4.5e-13 48.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA82678.1 - 5.3e-09 35.8 0.0 1e-05 25.3 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif zf-C3HC4_3 PF13920.6 EFA82678.1 - 0.0066 16.3 5.4 0.011 15.5 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_7 PF16367.5 EFA82678.1 - 0.026 14.7 0.6 1.1 9.4 0.0 3.2 3 0 0 3 3 3 0 RNA recognition motif zf-RING_5 PF14634.6 EFA82678.1 - 0.085 12.8 3.7 0.22 11.5 3.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA82678.1 - 0.14 12.1 5.8 0.31 11.0 5.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SPT6_acidic PF14632.6 EFA82679.1 - 0.0055 17.3 17.3 0.0055 17.3 17.3 3.5 4 0 0 4 4 4 1 Acidic N-terminal SPT6 Macoilin PF09726.9 EFA82679.1 - 0.01 14.5 30.3 0.012 14.2 30.3 1.0 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 EFA82679.1 - 0.074 10.8 19.4 0.084 10.6 19.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SWI-SNF_Ssr4 PF08549.10 EFA82679.1 - 0.37 9.4 16.5 0.4 9.3 16.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SRP-alpha_N PF04086.13 EFA82679.1 - 0.6 10.0 31.9 0.89 9.4 31.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal ketoacyl-synt PF00109.26 EFA82680.1 - 2.7e-69 233.5 0.0 9e-69 231.9 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA82680.1 - 2.7e-52 178.3 0.0 4e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA82680.1 - 1.5e-34 118.6 0.0 3.2e-34 117.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA82680.1 - 2.1e-33 115.7 0.0 6.1e-32 111.0 0.0 2.5 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFA82680.1 - 1.1e-32 113.4 0.0 2.8e-32 112.2 0.0 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA82680.1 - 2.8e-12 47.1 0.1 9.1e-12 45.4 0.1 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFA82680.1 - 1.9e-11 43.8 0.0 1.2e-09 37.9 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EFA82680.1 - 5.6e-09 37.1 0.0 1.7e-07 32.4 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFA82680.1 - 3e-08 33.7 0.0 1.5e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFA82680.1 - 7.6e-07 28.9 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_12 PF08242.12 EFA82680.1 - 0.0015 19.3 0.1 0.016 16.0 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Thiolase_N PF00108.23 EFA82680.1 - 0.0077 15.6 0.0 0.19 11.0 0.0 2.8 3 0 0 3 3 3 1 Thiolase, N-terminal domain ADH_N PF08240.12 EFA82680.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain ubiquitin PF00240.23 EFA82681.1 - 8.1e-13 47.9 0.0 1e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA82681.1 - 0.00063 19.5 0.0 0.00075 19.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFA82681.1 - 0.0051 16.9 0.0 0.011 15.9 0.0 1.6 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFA82681.1 - 0.0077 16.8 0.0 0.0089 16.6 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain VPS13 PF16908.5 EFA82682.1 - 4.9e-27 95.3 6.8 7.5e-24 84.8 0.4 3.8 3 0 0 3 3 3 3 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 EFA82683.1 - 1.8e-48 165.3 7.8 6.1e-45 153.7 0.8 4.3 3 2 1 4 4 4 3 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 EFA82683.1 - 9.6e-48 162.3 2.4 9.6e-48 162.3 2.4 3.4 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 EFA82683.1 - 9.7e-06 25.9 0.0 3.5e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain bPH_3 PF14470.6 EFA82683.1 - 0.017 15.5 1.1 0.074 13.4 0.2 2.7 2 0 0 2 2 2 0 Bacterial PH domain CS PF04969.16 EFA82684.1 - 1.6e-13 51.4 1.7 3e-13 50.6 1.7 1.4 1 0 0 1 1 1 1 CS domain Band_7 PF01145.25 EFA82685.1 - 2.3e-34 118.9 2.8 3.3e-34 118.4 2.8 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EFA82685.1 - 0.029 14.1 0.3 0.052 13.3 0.3 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family COX17 PF05051.13 EFA82686.1 - 0.0075 16.6 0.2 0.5 10.8 0.1 2.1 2 0 0 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 EFA82686.1 - 0.0075 16.4 1.7 0.86 9.8 0.1 2.2 2 0 0 2 2 2 2 CHCH domain COX6B PF02297.17 EFA82686.1 - 0.016 15.4 0.3 0.02 15.1 0.3 1.2 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EFA82686.1 - 0.055 13.5 4.1 0.063 13.3 1.3 2.0 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EFA82686.1 - 0.26 11.3 5.1 3.9 7.6 5.1 2.0 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Peptidase_M16_C PF05193.21 EFA82687.1 - 9.4e-24 84.4 0.1 4.3e-23 82.3 0.0 2.0 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFA82687.1 - 2.5e-18 66.5 0.6 6.1e-18 65.2 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Ins_allergen_rp PF06757.13 EFA82687.1 - 0.011 15.7 0.4 0.03 14.3 0.1 1.9 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification CH PF00307.31 EFA82688.1 - 1.7e-46 156.9 2.9 4.2e-24 84.8 0.0 3.3 4 0 0 4 4 4 2 Calponin homology (CH) domain Spectrin PF00435.21 EFA82688.1 - 7.3e-29 100.3 30.0 5.4e-10 39.7 4.3 4.7 4 0 0 4 4 4 4 Spectrin repeat GNT-I PF03071.15 EFA82688.1 - 3.1e-19 69.1 6.0 1.3e-18 67.0 6.0 2.1 1 1 0 1 1 1 1 GNT-I family CAMSAP_CH PF11971.8 EFA82688.1 - 6.9e-10 38.6 2.7 1.2e-07 31.4 0.0 3.8 4 0 0 4 4 4 1 CAMSAP CH domain EFhand_Ca_insen PF08726.10 EFA82688.1 - 2.5e-08 33.9 0.6 1.4e-07 31.5 0.1 2.7 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CH_2 PF06294.11 EFA82688.1 - 2.7e-05 24.2 2.5 0.22 11.6 0.0 4.3 5 0 0 5 5 5 2 CH-like domain in sperm protein EF-hand_6 PF13405.6 EFA82688.1 - 6.3e-05 22.6 0.0 0.0097 15.8 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EFA82688.1 - 0.00037 20.9 0.1 0.0024 18.3 0.1 2.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFA82688.1 - 0.035 13.6 0.0 0.19 11.4 0.0 2.4 1 0 0 1 1 1 0 EF hand PDEase_I PF00233.19 EFA82689.1 - 2.2e-58 197.8 6.4 5.2e-58 196.6 6.4 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF1764 PF08576.10 EFA82689.1 - 0.35 11.8 8.0 0.67 10.9 8.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Mem_trans PF03547.18 EFA82689.1 - 0.41 9.0 4.0 0.6 8.4 4.0 1.1 1 0 0 1 1 1 0 Membrane transport protein Macoilin PF09726.9 EFA82689.1 - 4.2 5.8 17.1 5.6 5.4 17.1 1.1 1 0 0 1 1 1 0 Macoilin family NST1 PF13945.6 EFA82689.1 - 7.4 6.6 23.0 15 5.6 23.0 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator HATPase_c PF02518.26 EFA82690.1 - 6.6e-33 113.6 0.1 1.9e-32 112.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA82690.1 - 1.2e-23 83.4 1.1 5.2e-21 74.9 0.1 3.1 3 0 0 3 3 3 2 Response regulator receiver domain HisKA PF00512.25 EFA82690.1 - 1.2e-18 66.9 0.0 2.8e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EFA82690.1 - 3.4e-09 36.9 0.0 1e-08 35.4 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 EFA82690.1 - 1.4e-05 25.3 0.0 3.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold tRNA-Thr_ED PF08915.11 EFA82690.1 - 0.0003 20.8 0.1 0.00073 19.6 0.1 1.6 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase HATPase_c_3 PF13589.6 EFA82690.1 - 0.008 16.0 0.0 0.034 14.0 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 EFA82690.1 - 0.015 15.3 0.0 0.058 13.4 0.0 2.0 1 0 0 1 1 1 0 PAS domain Zip PF02535.22 EFA82691.1 - 1e-48 166.3 15.3 7.4e-39 133.9 6.5 2.2 1 1 1 2 2 2 2 ZIP Zinc transporter DUF4407 PF14362.6 EFA82691.1 - 0.24 10.7 0.6 0.47 9.8 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_holin_5_2 PF16079.5 EFA82691.1 - 9.7 6.6 11.1 7 7.1 0.4 3.4 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V C2 PF00168.30 EFA82692.1 - 9.3e-07 29.1 0.0 2e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 C2 domain MSV199 PF10553.9 EFA82693.1 - 0.022 15.0 0.1 0.034 14.4 0.1 1.3 1 0 0 1 1 1 0 MSV199 domain CBS PF00571.28 EFA82694.1 - 7.8e-22 77.5 1.9 2.1e-12 47.3 0.2 2.2 2 0 0 2 2 2 2 CBS domain CBM49 PF09478.10 EFA82696.1 - 1.2e-16 60.8 0.1 1.6e-16 60.4 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 FYVE PF01363.21 EFA82697.1 - 0.012 15.7 9.0 0.014 15.5 7.0 2.2 2 0 0 2 2 2 0 FYVE zinc finger Gp138_N PF18352.1 EFA82697.1 - 0.027 14.5 0.0 0.065 13.3 0.0 1.7 1 0 0 1 1 1 0 Phage protein Gp138 N-terminal domain C1_1 PF00130.22 EFA82697.1 - 0.65 9.9 5.8 0.39 10.6 2.5 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 EFA82697.1 - 9.9 6.3 8.1 22 5.2 2.7 2.8 2 1 1 3 3 3 0 Double zinc ribbon Ras PF00071.22 EFA82698.1 - 2.6e-53 179.9 0.0 3e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82698.1 - 5.8e-22 78.2 0.0 8.3e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82698.1 - 1.1e-10 41.3 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA82698.1 - 1.8e-05 24.4 0.0 5.8e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain CBM49 PF09478.10 EFA82699.1 - 1.2e-16 60.8 0.1 1.6e-16 60.4 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Ras PF00071.22 EFA82700.1 - 4.5e-37 127.2 0.1 5.6e-37 126.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82700.1 - 4.1e-12 46.4 0.1 1.1e-11 45.0 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82700.1 - 0.0017 17.8 0.4 0.0038 16.7 0.4 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 EFA82700.1 - 0.08 12.7 0.3 2.6 7.7 0.0 2.2 1 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFA82700.1 - 0.089 13.1 1.5 7.8 6.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain CBM49 PF09478.10 EFA82701.1 - 2.3e-14 53.5 0.1 3.1e-14 53.0 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 HMG_box PF00505.19 EFA82702.1 - 0.098 13.1 0.0 13 6.3 0.0 2.7 2 0 0 2 2 2 0 HMG (high mobility group) box Ank_2 PF12796.7 EFA82703.1 - 5e-28 97.5 3.7 1.2e-06 29.0 0.1 7.3 4 1 4 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82703.1 - 1e-23 83.4 6.9 1.5e-05 25.4 0.1 9.0 8 2 2 10 10 10 5 Ankyrin repeats (many copies) UQ_con PF00179.26 EFA82703.1 - 1.1e-15 57.6 0.2 2.1e-15 56.6 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ank_5 PF13857.6 EFA82703.1 - 1.2e-13 51.0 2.4 0.59 10.5 0.0 9.4 6 2 5 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82703.1 - 4.9e-12 44.9 2.3 18 6.3 0.1 11.8 12 1 1 13 13 13 1 Ankyrin repeat PNK3P PF08645.11 EFA82704.1 - 9.3e-33 113.2 5.1 2.6e-17 63.0 0.0 3.0 2 1 1 3 3 3 2 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EFA82704.1 - 3e-20 72.9 0.7 1.8e-17 63.9 0.3 3.0 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 EFA82704.1 - 3.1e-07 30.1 9.4 4.1e-05 23.2 1.3 3.0 2 1 1 3 3 3 2 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 EFA82704.1 - 8.2e-05 22.0 0.7 0.085 12.1 0.3 2.8 2 1 1 3 3 3 2 Zeta toxin 6PF2K PF01591.18 EFA82704.1 - 0.0016 17.8 0.5 0.23 10.8 0.0 2.5 1 1 1 2 2 2 1 6-phosphofructo-2-kinase BSP_II PF05432.11 EFA82704.1 - 0.0027 17.5 20.8 0.0044 16.8 20.8 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Hydrolase_6 PF13344.6 EFA82704.1 - 0.029 14.5 0.0 2.4 8.3 0.0 2.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TFX_C PF14601.6 EFA82704.1 - 0.03 14.3 0.1 0.089 12.8 0.1 1.8 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Put_Phosphatase PF06888.12 EFA82704.1 - 0.093 12.1 0.2 8.3 5.7 0.0 3.0 2 1 1 3 3 3 0 Putative Phosphatase Tli4_N PF18443.1 EFA82704.1 - 0.57 10.5 3.5 0.86 10.0 0.2 2.7 2 1 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain PRAS PF15798.5 EFA82704.1 - 0.84 10.2 9.7 1.1 9.9 6.9 2.4 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 NOA36 PF06524.12 EFA82704.1 - 3.3 6.9 9.7 1 8.6 4.0 2.2 2 0 0 2 2 2 0 NOA36 protein DUF4551 PF15087.6 EFA82704.1 - 6.1 5.6 8.6 9.3 5.0 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DNA_pol_phi PF04931.13 EFA82704.1 - 6.3 4.8 14.3 9 4.3 14.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ecl1 PF12855.7 EFA82704.1 - 7 7.8 7.5 4.4 8.4 5.5 1.6 2 0 0 2 2 1 0 ECL1/2/3 zinc binding proteins Usp PF00582.26 EFA82704.1 - 8.4 6.9 0.0 8.4 6.9 0.0 3.2 2 1 0 2 2 1 0 Universal stress protein family Cyclin_N PF00134.23 EFA82706.1 - 5.1e-09 36.0 0.0 7e-06 25.8 0.0 3.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFA82706.1 - 0.0013 18.8 0.0 0.0013 18.8 0.0 4.6 4 2 1 5 5 5 1 Cyclin, C-terminal domain MFS_1 PF07690.16 EFA82707.1 - 1.1e-30 106.8 16.8 1.6e-30 106.2 16.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA82707.1 - 2.9e-08 33.0 5.8 2.9e-08 33.0 5.8 3.0 2 1 0 3 3 3 2 Sugar (and other) transporter TMEM192 PF14802.6 EFA82707.1 - 0.012 14.7 1.2 0.93 8.5 0.0 2.7 3 0 0 3 3 3 0 TMEM192 family MFS_1 PF07690.16 EFA82708.1 - 2.4e-40 138.5 28.0 1.6e-26 93.1 15.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA82708.1 - 7.7e-10 38.2 23.0 1.2e-07 31.0 23.1 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 EFA82708.1 - 1.5e-07 30.4 2.1 1.5e-07 30.4 2.1 2.8 2 1 0 3 3 3 1 MFS/sugar transport protein Nodulin-like PF06813.13 EFA82708.1 - 0.0067 15.9 1.4 0.0067 15.9 1.4 2.1 3 0 0 3 3 3 1 Nodulin-like MFS_1 PF07690.16 EFA82709.1 - 1.2e-27 96.8 44.5 3.9e-20 72.1 24.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA82709.1 - 0.081 11.8 29.3 0.11 11.3 15.2 2.5 2 1 0 2 2 2 0 Sugar (and other) transporter MFS_1 PF07690.16 EFA82710.1 - 3.2e-26 92.1 19.9 4.4e-26 91.6 19.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA82710.1 - 2.6e-06 26.6 34.0 1.4e-05 24.2 33.3 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter Opy2 PF09463.10 EFA82711.1 - 0.41 11.0 42.0 0.28 11.6 7.3 4.8 2 2 2 4 4 4 0 Opy2 protein MAPEG PF01124.18 EFA82713.1 - 1.6e-25 89.5 0.4 1.8e-25 89.3 0.4 1.0 1 0 0 1 1 1 1 MAPEG family MAPEG PF01124.18 EFA82714.1 - 7.6e-24 84.1 0.8 8.8e-24 83.9 0.8 1.0 1 0 0 1 1 1 1 MAPEG family MAPEG PF01124.18 EFA82715.1 - 1.7e-25 89.4 0.1 1.9e-25 89.2 0.1 1.0 1 0 0 1 1 1 1 MAPEG family DUF846 PF05832.12 EFA82716.1 - 1.1e-51 174.5 12.5 2e-51 173.7 12.5 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF3430 PF11912.8 EFA82716.1 - 1.1e-23 84.5 12.3 2e-23 83.5 12.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) DUF3053 PF11254.8 EFA82718.1 - 0.22 11.1 1.2 0.35 10.4 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) ALMT PF11744.8 EFA82718.1 - 0.54 9.0 4.0 0.9 8.3 4.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Macoilin PF09726.9 EFA82718.1 - 0.56 8.7 6.7 0.85 8.1 6.7 1.2 1 0 0 1 1 1 0 Macoilin family IL10 PF00726.17 EFA82720.1 - 0.076 12.5 0.1 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Interleukin 10 7TMR-DISM_7TM PF07695.11 EFA82721.1 - 4.9 7.0 10.6 1.2 9.0 5.5 2.1 2 0 0 2 2 2 0 7TM diverse intracellular signalling Tho2 PF11262.8 EFA82722.1 - 3.6e-81 272.7 9.8 3.6e-81 272.7 9.8 6.4 3 2 4 7 7 7 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 EFA82722.1 - 7e-68 229.8 19.9 1.1e-48 166.4 11.9 7.1 3 2 2 5 5 5 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 EFA82722.1 - 1.9e-26 91.9 0.1 1.3e-25 89.2 0.1 2.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit GxGYxYP_C PF14323.6 EFA82722.1 - 2.1 8.1 4.8 1 9.2 0.0 2.6 2 0 0 2 2 2 0 GxGYxYP putative glycoside hydrolase C-terminal domain Cyclin PF08613.11 EFA82724.1 - 1.9e-14 54.4 0.1 2.3e-14 54.0 0.1 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFA82724.1 - 0.0017 18.1 0.0 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Thioredoxin_6 PF13848.6 EFA82724.1 - 0.038 13.9 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Imm15 PF15561.6 EFA82724.1 - 0.092 13.0 0.3 0.16 12.2 0.1 1.5 1 1 1 2 2 2 0 Immunity protein 15 DUF417 PF04224.12 EFA82725.1 - 0.018 14.6 1.7 0.03 13.9 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF417 Wzz PF02706.15 EFA82725.1 - 0.04 14.2 2.7 0.33 11.3 1.5 2.4 2 0 0 2 2 2 0 Chain length determinant protein DUF4131 PF13567.6 EFA82725.1 - 0.15 11.7 1.6 0.38 10.4 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Gram_pos_anchor PF00746.21 EFA82725.1 - 0.21 11.5 10.1 0.21 11.6 0.5 3.2 3 0 0 3 3 3 0 LPXTG cell wall anchor motif LRR19-TM PF15176.6 EFA82725.1 - 0.76 9.8 3.4 31 4.7 0.1 3.0 2 1 1 3 3 3 0 Leucine-rich repeat family 19 TM domain Comm PF15957.5 EFA82725.1 - 6.3 7.2 0.0 6.3 7.2 0.0 3.0 3 1 0 3 3 3 0 Commissureless Creatinase_N_2 PF16189.5 EFA82726.1 - 4.9e-50 169.8 0.0 1.4e-49 168.3 0.0 1.7 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EFA82726.1 - 8.8e-42 143.2 0.2 1.2e-41 142.7 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EFA82726.1 - 2.7e-25 89.5 0.1 8.4e-20 71.8 0.1 2.3 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EFA82726.1 - 1.1e-20 73.4 0.0 3.8e-20 71.7 0.0 2.0 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Cu-oxidase PF00394.22 EFA82727.1 - 0.033 14.3 0.0 0.036 14.2 0.0 1.1 1 0 0 1 1 1 0 Multicopper oxidase LRR_9 PF14580.6 EFA82728.1 - 1.8e-09 37.4 1.3 6.7e-09 35.5 1.3 1.9 1 0 0 1 1 1 1 Leucine-rich repeat CG-1 PF03859.16 EFA82728.1 - 0.16 11.8 0.1 0.16 11.8 0.1 3.3 3 1 0 3 3 3 0 CG-1 domain Telomere_reg-2 PF10193.9 EFA82729.1 - 3.9e-27 94.9 0.2 3.9e-27 94.9 0.2 4.1 5 0 0 5 5 5 1 Telomere length regulation protein Dicty_CTDC PF00526.18 EFA82732.1 - 1.4e-19 69.7 361.2 8.2e-09 35.2 8.4 25.0 21 7 2 23 23 23 15 Dictyostelium (slime mold) repeat XS PF03468.14 EFA82732.1 - 0.095 13.0 0.2 0.2 12.0 0.2 1.4 1 0 0 1 1 1 0 XS domain Phytochelatin PF05023.14 EFA82733.1 - 2.7e-13 49.7 0.1 2.7e-13 49.7 0.1 2.3 2 0 0 2 2 2 1 Phytochelatin synthase TFIIA PF03153.13 EFA82733.1 - 0.65 9.9 20.5 0.73 9.8 20.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 EFA82733.1 - 0.68 9.9 15.0 0.92 9.5 15.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Kinesin_assoc PF16183.5 EFA82733.1 - 0.71 10.0 4.8 1.2 9.2 4.8 1.3 1 0 0 1 1 1 0 Kinesin-associated LMBR1 PF04791.16 EFA82733.1 - 1.5 7.7 7.2 1.6 7.5 7.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Presenilin PF01080.17 EFA82733.1 - 1.5 7.5 11.1 1.6 7.4 11.1 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 EFA82733.1 - 2.1 8.4 14.3 2.8 8.0 14.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CxxCxxCC PF03692.15 EFA82733.1 - 3.5 8.4 9.8 8.6 7.1 9.9 1.7 1 1 0 1 1 1 0 Putative zinc- or iron-chelating domain ALMT PF11744.8 EFA82733.1 - 4.9 5.9 11.1 6.9 5.4 11.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Mpv17_PMP22 PF04117.12 EFA82735.1 - 0.0056 16.9 0.3 0.011 15.9 0.3 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family PetN PF03742.14 EFA82735.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 PetN DUF2722 PF10846.8 EFA82737.1 - 0.0036 16.3 5.8 0.0043 16.1 5.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF5335 PF17269.2 EFA82737.1 - 0.026 14.4 0.2 0.039 13.8 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5335) Fcf1 PF04900.12 EFA82738.1 - 1.6e-11 44.4 0.1 1.6e-11 44.4 0.1 1.9 2 0 0 2 2 2 1 Fcf1 DUF3439 PF11921.8 EFA82738.1 - 0.0055 16.7 4.1 0.013 15.4 4.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Nop14 PF04147.12 EFA82738.1 - 0.055 11.7 32.6 0.079 11.2 32.6 1.1 1 0 0 1 1 1 0 Nop14-like family AJAP1_PANP_C PF15298.6 EFA82738.1 - 0.26 11.5 7.0 0.47 10.6 7.0 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Sporozoite_P67 PF05642.11 EFA82738.1 - 1.5 6.8 18.2 2.1 6.3 18.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDK2AP PF09806.9 EFA82738.1 - 2.4 8.2 17.8 0.57 10.2 10.6 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein TFIIF_alpha PF05793.12 EFA82738.1 - 4.2 5.9 42.7 7.2 5.1 42.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SSP160 PF06933.11 EFA82738.1 - 7.4 4.6 11.6 15 3.6 11.6 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dishevelled PF02377.15 EFA82738.1 - 9.1 6.7 24.1 0.25 11.8 17.3 1.8 2 0 0 2 2 2 0 Dishevelled specific domain Glycos_transf_1 PF00534.20 EFA82739.1 - 1.9e-38 131.7 0.0 3.1e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA82739.1 - 5.2e-17 62.5 0.0 8.2e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFA82739.1 - 1.4e-14 54.5 0.0 1.4e-14 54.5 0.0 2.6 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EFA82739.1 - 4.2e-05 23.9 0.0 0.0001 22.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Methyltransf_31 PF13847.6 EFA82740.1 - 5.1e-07 29.6 0.3 4.6e-06 26.5 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFA82740.1 - 2.9e-06 27.0 0.1 0.00026 20.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 EFA82740.1 - 3.9e-06 26.5 0.0 7.9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EFA82740.1 - 0.00017 22.3 0.1 0.00084 20.0 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA82740.1 - 0.00056 19.8 0.0 0.0019 18.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFA82740.1 - 0.0047 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFA82740.1 - 0.03 14.1 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 EFA82740.1 - 0.04 13.9 0.4 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFA82740.1 - 0.043 14.6 0.0 0.043 14.6 0.0 4.0 3 2 0 3 3 3 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFA82740.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family LRR_6 PF13516.6 EFA82741.1 - 3.1e-45 148.4 16.5 5.3e-07 29.2 0.4 9.3 9 0 0 9 9 9 9 Leucine Rich repeat LRR_1 PF00560.33 EFA82741.1 - 0.00025 21.2 10.5 18 6.3 0.1 7.8 8 2 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.7 EFA82741.1 - 1.5 9.3 35.6 2.2 8.8 1.8 6.7 2 2 4 6 6 6 0 Leucine Rich repeats (2 copies) Helicase_C_2 PF13307.6 EFA82742.1 - 1.4e-55 188.1 0.0 4.8e-55 186.4 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFA82742.1 - 2.1e-48 164.2 0.6 5.4e-48 162.9 0.6 1.7 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 EFA82742.1 - 0.0045 16.8 3.9 0.052 13.3 2.1 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase CENP-B_dimeris PF09026.10 EFA82742.1 - 0.01 16.2 11.2 0.31 11.5 10.5 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain HBB PF06777.11 EFA82742.1 - 0.13 12.0 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Helical and beta-bridge domain Mg_chelatase PF01078.21 EFA82742.1 - 0.41 10.0 2.4 0.34 10.3 0.1 2.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Mucin PF01456.17 EFA82742.1 - 0.93 9.5 19.6 3.3 7.7 19.6 1.9 1 0 0 1 1 1 0 Mucin-like glycoprotein ResIII PF04851.15 EFA82742.1 - 2.2 8.2 24.2 0.02 14.9 6.1 3.7 3 1 0 4 4 4 0 Type III restriction enzyme, res subunit Cwf_Cwc_15 PF04889.12 EFA82742.1 - 6.9 6.3 26.6 10 5.8 18.8 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein HMG_box PF00505.19 EFA82743.1 - 0.086 13.3 0.5 25 5.4 0.0 3.2 3 1 1 4 4 4 0 HMG (high mobility group) box HTH_Tnp_4 PF13613.6 EFA82744.1 - 4.8e-10 39.0 0.1 8.5e-10 38.2 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_4 PF13359.6 EFA82744.1 - 3.2e-09 36.7 0.1 6.9e-09 35.6 0.1 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Pox_Ag35 PF03286.14 EFA82744.1 - 0.0027 17.5 8.2 0.0027 17.5 8.2 2.1 2 0 0 2 2 2 1 Pox virus Ag35 surface protein Tim54 PF11711.8 EFA82744.1 - 0.0048 15.7 4.5 0.0048 15.7 4.5 1.8 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 RNA_pol_3_Rpc31 PF11705.8 EFA82744.1 - 0.012 15.9 7.6 0.012 15.9 7.6 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 EFA82744.1 - 0.014 15.8 4.7 0.035 14.5 4.7 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PPP4R2 PF09184.11 EFA82744.1 - 0.021 14.4 21.1 0.018 14.6 5.1 3.1 3 0 0 3 3 3 0 PPP4R2 S-antigen PF05756.11 EFA82744.1 - 0.022 15.1 7.8 0.063 13.7 7.8 1.8 1 0 0 1 1 1 0 S-antigen protein SID-1_RNA_chan PF13965.6 EFA82744.1 - 0.027 12.9 7.3 0.013 14.0 4.1 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CNDH2_N PF06278.11 EFA82744.1 - 0.028 14.6 9.0 0.044 14.0 3.8 2.9 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Connexin PF00029.19 EFA82744.1 - 0.031 14.0 1.7 0.076 12.8 1.7 1.6 1 0 0 1 1 1 0 Connexin Ureide_permease PF07168.11 EFA82744.1 - 0.06 12.1 0.5 0.12 11.1 0.5 1.4 1 0 0 1 1 1 0 Ureide permease CCDC53 PF10152.9 EFA82744.1 - 0.099 13.1 11.4 1.1 9.6 4.5 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex PBP1_TM PF14812.6 EFA82744.1 - 0.11 12.8 11.9 0.11 12.8 6.2 2.8 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Serinc PF03348.15 EFA82744.1 - 0.27 10.1 2.9 0.49 9.3 2.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 EFA82744.1 - 1.3 8.0 8.2 0.056 12.5 2.0 1.7 2 0 0 2 2 2 0 CLN3 protein DNA_pol_phi PF04931.13 EFA82744.1 - 1.5 6.8 17.0 2.6 6.0 17.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF913 PF06025.12 EFA82744.1 - 2.6 6.9 8.4 0.24 10.3 2.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4611 PF15387.6 EFA82744.1 - 3.2 8.0 17.2 5.1 7.4 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3464 PF11947.8 EFA82744.1 - 5.6 6.7 6.6 21 4.9 6.6 1.9 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 FAM176 PF14851.6 EFA82744.1 - 8.4 6.0 16.7 0.34 10.6 9.0 2.3 2 0 0 2 2 2 0 FAM176 family Ank_2 PF12796.7 EFA82745.1 - 8.8e-24 83.9 15.3 5.4e-08 33.3 0.4 7.9 4 3 7 11 11 11 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82745.1 - 4.2e-18 65.5 14.1 0.00014 22.3 0.0 9.2 10 1 1 11 11 11 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA82745.1 - 4.5e-15 55.5 10.7 0.086 13.2 0.0 9.4 4 2 6 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82745.1 - 2.9e-08 33.3 18.5 1 10.1 0.0 11.7 14 0 0 14 14 14 2 Ankyrin repeat Ank PF00023.30 EFA82745.1 - 0.0015 18.9 1.8 1.6 9.3 0.0 4.9 6 0 0 6 6 6 1 Ankyrin repeat CTK3 PF12243.8 EFA82745.1 - 0.076 13.0 1.1 0.7 9.9 0.0 3.0 3 0 0 3 3 3 0 CTD kinase subunit gamma CTK3 EGF_2 PF07974.13 EFA82747.1 - 0.0012 19.1 12.0 0.0012 19.1 12.0 1.9 2 0 0 2 2 2 1 EGF-like domain CBM49 PF09478.10 EFA82748.1 - 8.1e-15 54.9 0.2 1.8e-14 53.8 0.2 1.6 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Cnd1 PF12717.7 EFA82748.1 - 4.5e-05 23.5 4.6 0.00012 22.2 0.1 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFA82748.1 - 0.002 18.2 0.0 0.71 10.3 0.0 3.2 2 0 0 2 2 2 1 HEAT repeat HEAT_2 PF13646.6 EFA82748.1 - 0.0023 18.3 0.0 0.0078 16.6 0.0 1.9 2 0 0 2 2 2 1 HEAT repeats DUF3894 PF13033.6 EFA82748.1 - 0.11 12.6 0.5 0.22 11.6 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3894) MAGE PF01454.19 EFA82749.1 - 9.8e-37 126.7 0.1 9.8e-37 126.7 0.1 2.0 2 0 0 2 2 2 1 MAGE family DUF3439 PF11921.8 EFA82749.1 - 0.017 15.1 2.4 0.032 14.2 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF1154 PF06631.11 EFA82749.1 - 0.056 13.5 0.3 0.12 12.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) SSP160 PF06933.11 EFA82749.1 - 0.34 9.1 6.5 0.53 8.4 6.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Nop14 PF04147.12 EFA82749.1 - 1.1 7.4 11.6 0.26 9.5 2.4 2.1 2 0 0 2 2 2 0 Nop14-like family CDC45 PF02724.14 EFA82749.1 - 1.9 6.7 9.3 1.1 7.4 3.2 2.1 2 0 0 2 2 2 0 CDC45-like protein SCP2 PF02036.17 EFA82750.1 - 1.9e-54 182.4 1.6 6.9e-28 97.1 0.3 2.1 2 0 0 2 2 2 2 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EFA82750.1 - 1.1e-13 51.5 0.1 1.2e-06 28.9 0.1 2.2 2 0 0 2 2 2 2 Alkyl sulfatase C-terminal PHA_gran_rgn PF09650.10 EFA82750.1 - 0.03 14.6 0.1 2.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) HMA PF00403.26 EFA82750.1 - 0.25 11.8 1.2 33 5.0 0.1 2.8 3 0 0 3 3 3 0 Heavy-metal-associated domain FNIP PF05725.12 EFA82751.1 - 7.1e-53 176.5 22.8 3.8e-10 39.8 0.0 7.6 3 2 6 10 10 10 9 FNIP Repeat Nucleoporin_FG PF13634.6 EFA82751.1 - 0.18 12.6 68.6 0.25 12.2 23.8 4.4 1 1 2 3 3 3 0 Nucleoporin FG repeat region PHD PF00628.29 EFA82752.1 - 1.9e-05 24.5 19.2 0.0003 20.6 4.9 3.7 3 0 0 3 3 3 2 PHD-finger PHD_4 PF16866.5 EFA82752.1 - 3.4 7.8 15.2 0.1 12.7 6.8 3.0 2 1 0 2 2 2 0 PHD-finger PHD_2 PF13831.6 EFA82752.1 - 8.2 6.1 16.4 0.042 13.4 4.3 2.9 2 1 1 3 3 3 0 PHD-finger EGF_2 PF07974.13 EFA82753.1 - 0.00023 21.5 21.1 0.0029 17.9 9.6 2.8 2 0 0 2 2 2 2 EGF-like domain Laminin_EGF PF00053.24 EFA82753.1 - 0.051 13.7 15.0 0.22 11.7 3.6 2.8 1 1 1 2 2 2 0 Laminin EGF domain EGF PF00008.27 EFA82753.1 - 3.7 7.9 15.5 8.4 6.8 2.4 2.8 2 0 0 2 2 2 0 EGF-like domain Diphthamide_syn PF01866.17 EFA82754.1 - 2e-89 300.0 10.3 4.1e-87 292.5 10.3 2.2 1 1 0 1 1 1 1 Putative diphthamide synthesis protein COPI_assoc PF08507.10 EFA82755.1 - 0.00041 20.4 0.2 0.00041 20.4 0.2 2.4 1 1 1 2 2 2 1 COPI associated protein DJ-1_PfpI PF01965.24 EFA82756.1 - 3.2e-14 53.1 0.0 8.2e-13 48.5 0.0 2.1 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EFA82756.1 - 9.8e-07 28.7 0.0 4.5e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 ThiJ/PfpI family-like HGTP_anticodon PF03129.20 EFA82757.1 - 9.7e-23 80.1 0.0 2.4e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFA82757.1 - 5e-11 42.9 0.0 1.3e-10 41.6 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SasG_E PF17041.5 EFA82757.1 - 0.17 11.9 0.1 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 E domain Med3 PF11593.8 EFA82760.1 - 0.082 12.1 41.3 0.056 12.6 22.6 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal zf-UDP PF14569.6 EFA82760.1 - 0.16 12.1 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding RING-finger Ldh_1_C PF02866.18 EFA82761.1 - 1.8e-33 115.8 0.6 2.6e-33 115.3 0.1 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFA82761.1 - 4.6e-33 114.3 0.4 7.2e-33 113.6 0.4 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain SET PF00856.28 EFA82762.1 - 9.9e-12 45.6 4.5 9.9e-12 45.6 4.5 2.2 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EFA82762.1 - 1.1e-05 26.1 0.1 2.4e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Secretin_N_2 PF07655.13 EFA82762.1 - 0.62 10.7 47.5 0.39 11.3 21.7 3.5 3 0 0 3 3 3 0 Secretin N-terminal domain Folate_carrier PF01770.18 EFA82762.1 - 1.4 7.5 7.4 0.45 9.2 0.9 2.4 2 0 0 2 2 2 0 Reduced folate carrier AMP-binding PF00501.28 EFA82763.1 - 1.3e-45 155.8 0.0 1.9e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ZZ PF00569.17 EFA82763.1 - 0.069 13.0 8.9 0.16 11.8 8.9 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type MFS_1 PF07690.16 EFA82764.1 - 1.3e-06 27.6 23.1 1.3e-06 27.6 23.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily SCO1-SenC PF02630.14 EFA82766.1 - 6.7e-46 155.5 0.0 1.6e-45 154.3 0.0 1.7 2 0 0 2 2 2 1 SCO1/SenC Thioredoxin_8 PF13905.6 EFA82766.1 - 0.0005 20.4 0.0 0.0005 20.4 0.0 1.9 2 0 0 2 2 1 1 Thioredoxin-like DUF4366 PF14283.6 EFA82766.1 - 0.0086 16.1 0.1 0.015 15.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) AhpC-TSA PF00578.21 EFA82766.1 - 0.012 15.5 0.0 0.031 14.2 0.0 1.7 1 1 0 1 1 1 0 AhpC/TSA family MAP70 PF07058.11 EFA82766.1 - 0.045 12.5 4.5 0.063 12.0 4.5 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Connexin PF00029.19 EFA82766.1 - 0.045 13.5 1.1 0.065 13.0 1.1 1.2 1 0 0 1 1 1 0 Connexin ETRAMP PF09716.10 EFA82766.1 - 0.059 13.4 0.2 0.14 12.2 0.2 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Peroxin-13_N PF04088.13 EFA82766.1 - 0.08 13.2 0.6 0.27 11.5 0.4 2.0 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Thioredoxin_2 PF13098.6 EFA82766.1 - 0.13 12.7 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Zip PF02535.22 EFA82766.1 - 0.13 11.4 1.1 0.18 11.0 1.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CrgA PF06781.12 EFA82766.1 - 0.16 12.1 0.1 0.35 10.9 0.1 1.6 1 1 0 1 1 1 0 Cell division protein CrgA Presenilin PF01080.17 EFA82766.1 - 0.27 9.9 4.0 0.36 9.5 4.0 1.2 1 0 0 1 1 1 0 Presenilin Apc15p PF05841.11 EFA82766.1 - 0.45 11.3 15.1 1.3 9.9 15.1 1.8 1 1 0 1 1 1 0 Apc15p protein EIIBC-GUT_N PF03612.14 EFA82766.1 - 0.64 9.7 3.2 0.98 9.1 2.3 1.7 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Menin PF05053.13 EFA82766.1 - 1.2 7.4 5.4 1.7 6.9 5.4 1.1 1 0 0 1 1 1 0 Menin CSG2 PF16965.5 EFA82766.1 - 1.7 7.5 4.5 2.3 7.1 4.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4834 PF16118.5 EFA82766.1 - 2.8 9.0 7.8 5.2 8.1 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4580 PF15162.6 EFA82767.1 - 0.0033 17.0 1.4 0.005 16.4 1.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4580) MmgE_PrpD PF03972.14 EFA82768.1 - 8.7e-141 469.4 0.0 9.8e-141 469.3 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family ketoacyl-synt PF00109.26 EFA82769.1 - 1.7e-68 231.0 0.0 3.1e-68 230.1 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA82769.1 - 7.2e-44 150.6 0.0 1.1e-43 150.0 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFA82769.1 - 5.5e-33 114.4 0.2 1.6e-32 112.9 0.1 1.9 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFA82769.1 - 8.2e-23 81.1 0.0 1.3e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EFA82769.1 - 3e-18 66.0 0.0 7.5e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFA82769.1 - 2e-13 50.7 0.0 6.3e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EFA82769.1 - 1.5e-10 41.3 0.0 3.6e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.6 EFA82769.1 - 1.2e-07 32.9 0.0 4e-07 31.1 0.0 1.9 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Thiolase_N PF00108.23 EFA82769.1 - 7e-05 22.3 0.2 0.00021 20.8 0.1 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain ADH_N PF08240.12 EFA82769.1 - 0.00039 20.3 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFA82769.1 - 0.11 12.4 0.0 0.42 10.6 0.0 1.9 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_2 PF00891.18 EFA82770.1 - 3.7e-45 153.8 0.0 4.9e-45 153.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA82770.1 - 0.0023 17.9 0.0 0.0049 16.8 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain Trns_repr_metal PF02583.17 EFA82770.1 - 0.087 13.2 0.0 5.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor ketoacyl-synt PF00109.26 EFA82771.1 - 1.4e-68 231.3 0.0 2.5e-68 230.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA82771.1 - 3.4e-45 154.9 0.0 5.2e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFA82771.1 - 1.3e-31 110.0 0.3 2.9e-31 108.8 0.1 1.8 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFA82771.1 - 9.8e-23 80.8 0.0 1.5e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EFA82771.1 - 3.1e-18 65.9 0.0 7.6e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFA82771.1 - 4.9e-13 49.5 0.0 1.5e-12 48.0 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EFA82771.1 - 3e-10 40.3 0.0 7.3e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.6 EFA82771.1 - 5.3e-08 34.0 0.0 2e-07 32.2 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Thiolase_N PF00108.23 EFA82771.1 - 6.7e-05 22.4 0.3 0.00019 20.9 0.3 1.7 1 1 0 1 1 1 1 Thiolase, N-terminal domain ADH_N PF08240.12 EFA82771.1 - 0.00025 20.9 0.0 0.00066 19.5 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFA82771.1 - 0.0066 16.4 0.0 0.025 14.6 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF676 PF05057.14 EFA82772.1 - 9.9e-38 129.8 0.1 9.9e-38 129.8 0.1 1.9 2 0 0 2 2 2 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 EFA82772.1 - 9.5e-11 42.1 0.0 5.9e-10 39.6 0.0 2.5 1 0 0 1 1 1 1 Protein FAM135 Palm_thioest PF02089.15 EFA82772.1 - 9.4e-08 32.2 0.0 9.4e-08 32.2 0.0 2.6 2 2 1 3 3 3 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EFA82772.1 - 2.3e-06 27.5 0.5 2.3e-06 27.5 0.5 3.1 3 1 0 3 3 3 1 PGAP1-like protein DUF915 PF06028.11 EFA82772.1 - 0.00011 21.6 0.0 0.00011 21.6 0.0 2.9 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 EFA82772.1 - 0.035 14.0 1.0 0.077 12.9 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) VCBS PF13517.6 EFA82773.1 - 4.7e-20 72.0 23.8 7.4e-08 32.9 0.9 6.6 5 2 2 7 7 7 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFA82773.1 - 1e-18 67.1 18.6 0.00057 20.0 0.7 6.5 6 0 0 6 6 6 6 FG-GAP repeat Itfg2 PF15907.5 EFA82773.1 - 1.9e-06 27.2 5.6 1.6 7.7 0.0 6.0 6 1 0 7 7 7 4 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 EFA82773.1 - 2.1e-06 27.7 1.7 0.34 11.0 0.0 6.0 7 0 0 7 7 7 1 Ciliary BBSome complex subunit 2, middle region PQQ PF01011.21 EFA82773.1 - 0.0006 19.6 0.1 0.35 10.9 0.0 4.4 4 0 0 4 4 4 1 PQQ enzyme repeat PliI PF16743.5 EFA82773.1 - 0.013 15.2 4.7 12 5.6 0.1 4.6 5 0 0 5 5 5 0 Periplasmic lysozyme inhibitor of I-type lysozyme TcdB_toxin_midN PF12256.8 EFA82773.1 - 0.022 14.1 4.4 7.1 6.0 0.0 5.2 6 0 0 6 6 6 0 Insecticide toxin TcdB middle/N-terminal region PARP PF00644.20 EFA82774.1 - 5.4e-69 231.7 0.0 1.7e-68 230.1 0.0 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFA82774.1 - 6.8e-40 136.3 3.4 1.5e-39 135.2 3.4 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PADR1 PF08063.12 EFA82774.1 - 1.6e-17 63.0 1.2 3.8e-17 61.8 1.2 1.7 1 0 0 1 1 1 1 PADR1 (NUC008) domain zf-PARP PF00645.18 EFA82774.1 - 3.4e-14 53.5 10.9 4.8e-14 53.0 3.2 3.5 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 EFA82774.1 - 5.7e-14 51.9 0.1 1.5e-13 50.6 0.1 1.8 1 0 0 1 1 1 1 WGR domain BSP_II PF05432.11 EFA82774.1 - 0.0027 17.4 3.2 0.0027 17.4 3.2 2.2 3 0 0 3 3 3 1 Bone sialoprotein II (BSP-II) BRCT_2 PF16589.5 EFA82774.1 - 0.016 15.6 0.1 0.1 13.0 0.0 2.3 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Rrp44_CSD1 PF17216.3 EFA82774.1 - 0.031 14.0 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Rrp44-like cold shock domain IspD PF01128.19 EFA82774.1 - 0.057 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ORC_WH_C PF18137.1 EFA82774.1 - 0.13 12.4 1.5 0.35 10.9 1.5 1.7 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal CAC1F_C PF16885.5 EFA82774.1 - 0.33 10.6 4.1 0.88 9.2 4.1 1.6 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CobT PF06213.12 EFA82774.1 - 0.42 9.9 6.0 0.85 9.0 6.0 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT eIF-3c_N PF05470.12 EFA82774.1 - 0.82 7.9 7.7 0.055 11.8 1.8 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 EFA82774.1 - 1.2 7.2 9.6 2.2 6.3 9.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EFA82774.1 - 2.1 6.5 5.8 3.8 5.7 5.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Kelch_4 PF13418.6 EFA82776.1 - 6.7e-18 64.4 1.9 8.4e-07 28.9 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA82776.1 - 3.1e-14 52.6 5.6 8.6e-05 22.4 0.0 5.5 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFA82776.1 - 2.1e-07 30.4 0.8 0.049 13.2 0.0 4.2 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 EFA82776.1 - 3.4e-07 30.4 2.6 0.37 11.1 0.0 6.1 7 0 0 7 7 7 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA82776.1 - 2.2e-06 27.8 4.4 0.59 10.5 0.0 5.6 5 1 1 6 6 6 2 Kelch motif Kelch_2 PF07646.15 EFA82776.1 - 0.00011 22.0 2.9 3.1 7.9 0.1 4.0 3 0 0 3 3 3 2 Kelch motif DUF1764 PF08576.10 EFA82776.1 - 0.25 12.2 2.3 0.44 11.5 2.3 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3446 PF11928.8 EFA82776.1 - 1 9.7 18.3 0.21 11.9 4.7 2.7 1 1 1 2 2 2 0 Early growth response N-terminal domain Pex14_N PF04695.13 EFA82776.1 - 4.6 7.9 9.9 7.3 7.2 9.9 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 EFA82776.1 - 9.3 4.9 6.9 12 4.5 6.9 1.1 1 0 0 1 1 1 0 Presenilin EMP24_GP25L PF01105.24 EFA82777.1 - 1.4e-38 132.6 1.0 1.6e-38 132.5 1.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RskA PF10099.9 EFA82778.1 - 0.024 14.9 6.0 0.83 9.9 1.9 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF1689 PF07954.11 EFA82778.1 - 0.037 14.4 1.3 0.037 14.4 1.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1689) Imm42 PF15593.6 EFA82778.1 - 0.91 10.0 4.9 0.52 10.8 0.6 2.4 2 0 0 2 2 2 0 Immunity protein 42 Gln-synt_C-ter PF18318.1 EFA82778.1 - 0.99 9.3 5.2 0.13 12.2 0.4 2.0 2 0 0 2 2 2 0 Glutamine synthetase C-terminal domain CTP_transf_like PF01467.26 EFA82779.1 - 3.7e-20 72.6 0.0 4.9e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF4535 PF15054.6 EFA82780.1 - 0.16 11.7 0.4 0.35 10.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) HEAT_EZ PF13513.6 EFA82781.1 - 2.6e-17 62.9 0.0 9.2e-06 26.1 0.0 7.7 8 0 0 8 8 8 3 HEAT-like repeat Importin_rep_4 PF18808.1 EFA82781.1 - 1.1e-15 57.7 3.1 3.4e-14 52.9 0.1 4.4 3 1 1 4 4 4 1 Importin repeat HEAT PF02985.22 EFA82781.1 - 1.6e-13 49.7 7.4 0.012 15.8 0.1 9.1 10 0 0 10 10 10 2 HEAT repeat HEAT_2 PF13646.6 EFA82781.1 - 2.9e-07 30.8 0.0 4.4 7.8 0.0 5.5 5 1 1 6 6 6 4 HEAT repeats Vac14_Fab1_bd PF12755.7 EFA82781.1 - 4.4e-07 30.4 5.6 0.0016 19.0 0.0 6.8 7 1 1 8 8 8 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 EFA82781.1 - 0.0013 18.5 4.8 2.2 8.0 0.0 4.7 5 0 0 5 5 5 2 rRNA processing/ribosome biogenesis MMS19_C PF12460.8 EFA82781.1 - 0.0014 17.8 7.4 0.4 9.7 0.0 6.0 5 1 0 5 5 5 1 RNAPII transcription regulator C-terminal Arm PF00514.23 EFA82781.1 - 0.04 14.0 0.1 4.1 7.6 0.0 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 EFA82781.1 - 0.05 13.8 0.5 5 7.5 0.0 4.0 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 CLASP_N PF12348.8 EFA82781.1 - 0.11 12.0 0.6 10 5.6 0.0 4.1 4 1 2 6 6 6 0 CLASP N terminal Peptidase_M22 PF00814.25 EFA82782.1 - 1.2e-33 117.0 0.0 1.4e-33 116.7 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family YycC PF14174.6 EFA82782.1 - 0.048 13.5 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 YycC-like protein Peptidase_M22 PF00814.25 EFA82783.1 - 2.9e-09 37.0 0.0 3.9e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family Ras PF00071.22 EFA82784.1 - 8.5e-48 162.0 0.0 9.9e-48 161.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA82784.1 - 1.3e-28 99.6 0.0 2.2e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA82784.1 - 4.4e-10 39.3 0.0 5.7e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EFA82784.1 - 0.00068 20.0 0.0 0.04 14.3 0.0 2.4 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 EFA82784.1 - 0.012 15.7 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA82784.1 - 0.027 14.0 0.1 0.15 11.6 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EFA82784.1 - 0.028 14.2 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFA82784.1 - 0.074 13.1 0.1 0.25 11.4 0.1 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFA82784.1 - 0.083 12.4 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 EFA82784.1 - 0.1 11.9 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA82784.1 - 0.12 11.5 0.5 1.3 8.1 0.1 2.4 2 1 1 3 3 3 0 G-protein alpha subunit RsgA_GTPase PF03193.16 EFA82784.1 - 0.12 12.2 0.0 0.91 9.4 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase ArgoMid PF16487.5 EFA82784.1 - 0.13 12.5 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Mid domain of argonaute AAA_33 PF13671.6 EFA82784.1 - 0.22 11.7 0.1 0.38 10.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA82784.1 - 0.24 11.7 0.0 0.34 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EFA82784.1 - 0.27 10.4 0.1 0.82 8.8 0.1 1.7 2 0 0 2 2 2 0 NB-ARC domain Med14 PF08638.11 EFA82785.1 - 2.6e-22 79.2 3.1 2.6e-22 79.2 3.1 3.5 5 0 0 5 5 5 1 Mediator complex subunit MED14 Med15 PF09606.10 EFA82785.1 - 0.1 11.3 31.2 0.065 11.9 8.3 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Lipl32 PF12103.8 EFA82785.1 - 0.46 10.1 5.1 0.13 12.0 1.4 1.9 2 0 0 2 2 2 0 Surface lipoprotein of Spirochaetales order Androgen_recep PF02166.16 EFA82785.1 - 1.2 7.9 27.9 1.9 7.3 10.4 2.2 2 0 0 2 2 2 0 Androgen receptor DUF1151 PF06625.11 EFA82786.1 - 0.0012 18.7 2.2 0.0019 18.1 2.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1151) Corazonin PF17308.2 EFA82786.1 - 0.0031 17.9 5.3 0.0042 17.5 5.3 1.3 1 0 0 1 1 1 1 Pro-corazonin KAP PF05804.12 EFA82786.1 - 0.011 14.0 1.8 0.011 13.9 1.8 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) Mucin PF01456.17 EFA82786.1 - 0.23 11.4 14.4 0.3 11.1 14.4 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4834 PF16118.5 EFA82786.1 - 0.3 12.1 2.6 0.36 11.8 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3439 PF11921.8 EFA82786.1 - 0.56 10.2 9.7 0.94 9.4 9.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Tir_receptor_C PF07489.11 EFA82786.1 - 5.9 6.8 14.7 7.9 6.4 14.7 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus RRN3 PF05327.11 EFA82787.1 - 1.5e-37 129.4 1.2 1.5e-37 129.4 1.2 3.2 2 2 1 3 3 3 1 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.12 EFA82787.1 - 0.37 10.2 22.0 0.71 9.2 22.0 1.4 1 0 0 1 1 1 0 SDA1 DUF2151 PF10221.9 EFA82787.1 - 0.51 8.9 4.2 0.79 8.3 4.2 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator SURF2 PF05477.11 EFA82787.1 - 0.59 9.8 6.8 1.2 8.8 6.8 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SAPS PF04499.15 EFA82787.1 - 0.85 8.3 6.5 1.3 7.7 6.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 EFA82787.1 - 5.3 6.3 20.2 9.9 5.4 20.2 1.4 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EFA82787.1 - 6.6 4.8 23.9 13 3.9 23.9 1.4 1 0 0 1 1 1 0 Nop14-like family DUF4820 PF16091.5 EFA82787.1 - 9 5.6 7.1 4.4 6.6 4.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Sigma70_ner PF04546.13 EFA82787.1 - 9.6 6.0 18.5 4 7.3 15.6 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region GTP_EFTU PF00009.27 EFA82788.1 - 9.2e-55 185.2 0.0 1.3e-54 184.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFA82788.1 - 4.8e-23 81.6 0.2 1.1e-22 80.4 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFA82788.1 - 4.8e-15 55.7 3.6 1.1e-14 54.6 3.6 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFA82788.1 - 9.1e-06 25.7 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Acetyltransf_3 PF13302.7 EFA82789.1 - 1.4e-10 42.0 0.0 2.5e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA82789.1 - 1.6e-06 28.4 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EFA82789.1 - 0.00098 19.3 0.2 0.0017 18.5 0.2 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EFA82789.1 - 0.068 12.7 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 GNAT acetyltransferase ketoacyl-synt PF00109.26 EFA82790.1 - 1.1e-69 234.8 0.0 1.6e-69 234.3 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA82790.1 - 1.1e-53 182.9 0.0 1.6e-53 182.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFA82790.1 - 8.3e-33 113.8 0.1 6e-32 111.0 0.0 2.4 3 0 0 3 3 3 1 KR domain Ketoacyl-synt_C PF02801.22 EFA82790.1 - 9.3e-31 106.3 0.2 2.2e-30 105.1 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EFA82790.1 - 9.2e-24 84.2 0.0 2.4e-23 82.9 0.0 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 EFA82790.1 - 1.8e-16 60.7 0.0 1e-15 58.3 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain adh_short PF00106.25 EFA82790.1 - 9.7e-13 48.0 0.0 2.5e-10 40.1 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 EFA82790.1 - 3.9e-09 36.6 0.0 1.4e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EFA82790.1 - 6.1e-09 35.9 0.0 1.9e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA82790.1 - 2e-07 31.6 0.0 3.2e-06 27.7 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA82790.1 - 9.8e-07 29.3 0.0 7.7e-06 26.5 0.0 2.7 3 0 0 3 3 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EFA82790.1 - 2.1e-06 27.5 0.0 5.3e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFA82790.1 - 6.7e-05 22.7 0.1 0.0012 18.7 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EFA82790.1 - 0.00014 23.0 0.0 0.00034 21.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA82790.1 - 0.0033 17.3 0.0 0.0068 16.3 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EFA82790.1 - 0.0036 17.6 0.1 0.02 15.3 0.0 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site DUF938 PF06080.12 EFA82790.1 - 0.0037 17.1 0.0 0.0091 15.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 EFA82790.1 - 0.0041 16.9 0.1 0.013 15.3 0.0 1.9 2 0 0 2 2 1 1 Lysine methyltransferase Thiolase_N PF00108.23 EFA82790.1 - 0.025 14.0 0.0 0.066 12.6 0.0 1.7 2 0 0 2 2 2 0 Thiolase, N-terminal domain DXP_reductoisom PF02670.16 EFA82790.1 - 0.17 12.6 0.3 0.9 10.3 0.0 2.4 3 0 0 3 3 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase ABC_tran PF00005.27 EFA82791.1 - 1.1e-26 94.0 0.0 1.7e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA82791.1 - 3.3e-06 27.2 0.9 0.0012 18.8 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFA82791.1 - 0.00013 22.4 0.1 0.0002 21.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFA82791.1 - 0.00044 20.2 0.0 0.0011 18.8 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase SbcCD_C PF13558.6 EFA82791.1 - 0.0076 16.5 0.2 0.16 12.2 0.2 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EFA82791.1 - 0.013 14.9 0.2 0.13 11.7 0.2 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain T6SS_VipA PF05591.12 EFA82791.1 - 0.018 14.9 0.1 0.034 13.9 0.1 1.4 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 RuvB_N PF05496.12 EFA82791.1 - 0.042 13.6 0.0 0.077 12.7 0.0 1.5 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EFA82791.1 - 0.071 13.0 0.4 4.4 7.2 0.1 2.3 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 EFA82791.1 - 0.087 12.6 0.0 0.76 9.5 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_29 PF13555.6 EFA82791.1 - 0.18 11.6 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Tfb2 PF03849.14 EFA82792.1 - 1.1e-110 370.0 10.6 1.3e-110 369.7 10.6 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EFA82792.1 - 1.5e-23 83.0 0.4 3.6e-23 81.8 0.4 1.7 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain DUF3627 PF12299.8 EFA82792.1 - 0.063 13.4 0.5 9 6.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3627) DUF3381 PF11861.8 EFA82792.1 - 0.097 12.5 0.5 0.6 9.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) APG6 PF04111.12 EFA82794.1 - 1.1e-06 28.7 2.1 1.1e-06 28.7 2.1 1.6 2 0 0 2 2 2 1 Apg6 BARA domain DUF4698 PF15769.5 EFA82794.1 - 1.2 8.1 7.3 1.3 8.0 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Presenilin PF01080.17 EFA82794.1 - 4.1 6.1 8.9 4.7 5.9 8.9 1.0 1 0 0 1 1 1 0 Presenilin TCP PF03634.13 EFA82794.1 - 8.2 7.0 10.5 10 6.7 10.5 1.1 1 0 0 1 1 1 0 TCP family transcription factor APG6_N PF17675.1 EFA82795.1 - 0.052 14.1 0.3 0.052 14.1 0.3 3.0 3 0 0 3 3 3 0 Apg6 coiled-coil region Thioredoxin PF00085.20 EFA82796.1 - 0.077 13.0 1.0 0.8 9.7 0.3 2.6 2 1 0 2 2 2 0 Thioredoxin YfhE PF14152.6 EFA82796.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 YfhE-like protein FeS_assembly_P PF01883.19 EFA82798.1 - 7.3e-09 35.7 0.0 1.1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein DUF86 PF01934.17 EFA82798.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF86 HEAT PF02985.22 EFA82799.1 - 1.3e-44 146.4 30.9 0.0015 18.6 0.1 23.4 25 0 0 25 25 24 10 HEAT repeat HEAT_EZ PF13513.6 EFA82799.1 - 1.5e-40 137.1 26.1 0.00011 22.6 0.0 17.9 17 2 2 19 19 17 8 HEAT-like repeat HEAT_2 PF13646.6 EFA82799.1 - 2.7e-33 114.2 7.4 0.00015 22.1 0.0 14.5 10 4 4 14 14 14 8 HEAT repeats Vac14_Fab1_bd PF12755.7 EFA82799.1 - 2.1e-20 73.1 0.0 0.0029 18.2 0.0 9.9 7 2 2 9 9 9 4 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFA82799.1 - 1.4e-14 54.2 13.0 0.0095 15.5 0.0 8.6 8 0 0 8 8 8 3 CLASP N terminal Cnd1 PF12717.7 EFA82799.1 - 6.3e-14 52.3 28.2 0.0098 15.9 0.1 12.3 11 4 2 13 13 13 3 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 EFA82799.1 - 7.5e-13 48.2 10.9 3.2e-05 23.2 0.0 7.4 5 2 0 6 6 6 3 Interferon-related developmental regulator (IFRD) UME PF08064.13 EFA82799.1 - 4.9e-09 36.0 4.2 0.026 14.4 0.0 7.5 7 1 0 7 7 7 2 UME (NUC010) domain DUF3437 PF11919.8 EFA82799.1 - 1.2e-07 31.6 3.8 3.5 7.6 0.0 7.1 6 0 0 6 6 6 2 Domain of unknown function (DUF3437) TAF6_C PF07571.13 EFA82799.1 - 3.7e-05 24.0 5.3 3.5 8.0 0.0 6.6 6 1 0 7 7 6 1 TAF6 C-terminal HEAT repeat domain Arm PF00514.23 EFA82799.1 - 0.00026 20.9 5.5 17 5.7 0.1 7.1 7 0 0 7 7 6 0 Armadillo/beta-catenin-like repeat ParcG PF10274.9 EFA82799.1 - 0.0044 17.2 23.4 17 5.5 0.0 9.8 7 4 3 10 10 10 0 Parkin co-regulated protein NUC173 PF08161.12 EFA82799.1 - 0.0052 16.5 4.3 2.5 7.7 0.0 5.7 6 0 0 6 6 6 1 NUC173 domain RNA_pol_Rpc4 PF05132.14 EFA82799.1 - 0.016 15.6 3.4 1.1 9.6 0.0 2.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 EFA82799.1 - 0.099 12.8 9.0 2.4 8.3 0.9 2.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal HEAT_PBS PF03130.16 EFA82799.1 - 1.4 9.8 9.8 1.7e+02 3.3 0.0 7.5 8 0 0 8 8 5 0 PBS lyase HEAT-like repeat Pinin_SDK_memA PF04696.13 EFA82799.1 - 2.7 8.1 26.7 6.7 6.8 13.1 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region DUF4746 PF15928.5 EFA82799.1 - 4 6.8 19.4 0.2 11.0 3.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) tRNA-synt_2c PF01411.19 EFA82800.1 - 4.4e-201 669.2 0.0 5.7e-201 668.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 EFA82800.1 - 4.8e-17 62.7 0.5 4.8e-17 62.7 0.5 2.1 2 0 0 2 2 2 1 DHHA1 domain tRNA_SAD PF07973.14 EFA82800.1 - 5e-14 52.1 0.0 1.7e-13 50.4 0.0 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain PALP PF00291.25 EFA82801.1 - 2.8e-63 214.1 0.1 3.5e-63 213.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme YAcAr PF10686.9 EFA82801.1 - 0.064 13.2 0.1 0.69 9.9 0.1 2.6 3 0 0 3 3 3 0 YspA, cpYpsA-related SLOG family AIRC PF00731.20 EFA82801.1 - 0.086 12.4 0.3 0.42 10.2 0.0 2.2 2 1 0 2 2 2 0 AIR carboxylase DUF3439 PF11921.8 EFA82801.1 - 0.59 10.1 9.9 12 5.9 8.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Phospholip_B PF04916.13 EFA82802.1 - 6.3e-156 520.1 16.7 9e-156 519.5 16.7 1.2 1 0 0 1 1 1 1 Phospholipase B DUF3021 PF11457.8 EFA82802.1 - 0.88 9.9 9.2 2 8.8 9.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) ELMO_CED12 PF04727.13 EFA82803.1 - 1.5e-44 152.2 0.0 3.3e-44 151.1 0.0 1.6 1 0 0 1 1 1 1 ELMO/CED-12 family Kri1 PF05178.12 EFA82803.1 - 0.12 12.9 1.2 1.2 9.8 0.0 2.5 2 1 0 2 2 2 0 KRI1-like family RA PF00788.23 EFA82804.1 - 0.14 12.8 0.0 0.22 12.2 0.0 1.5 1 1 0 1 1 1 0 Ras association (RalGDS/AF-6) domain F-box PF00646.33 EFA82807.1 - 6e-11 41.9 5.0 6.1e-11 41.9 3.2 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFA82807.1 - 3.3e-10 39.7 3.2 7.3e-10 38.6 3.2 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFA82807.1 - 0.0032 17.3 0.3 0.0081 16.0 0.3 1.7 1 0 0 1 1 1 1 F-box PRANC PF09372.10 EFA82807.1 - 0.14 12.5 2.9 0.35 11.2 0.0 2.9 3 0 0 3 3 3 0 PRANC domain DUF4034 PF13226.6 EFA82808.1 - 0.39 10.0 8.0 0.81 9.0 8.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4034) DUF4199 PF13858.6 EFA82808.1 - 1.7 9.0 2.8 5.9 7.3 2.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Cons_hypoth698 PF03601.14 EFA82810.1 - 4.1e-31 108.0 6.2 5.8e-31 107.5 6.2 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 698 PPTA PF01239.22 EFA82811.1 - 2e-42 141.8 9.0 6.5e-10 38.4 0.2 5.8 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat HECT_2 PF09814.9 EFA82811.1 - 3.4e-23 82.1 8.1 5.3e-23 81.5 8.1 1.2 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Yippee-Mis18 PF03226.14 EFA82811.1 - 0.14 12.4 2.2 0.13 12.5 0.4 1.9 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Cnn_1N PF07989.11 EFA82811.1 - 0.53 10.5 4.7 1.3 9.2 4.7 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Raptor_N PF14538.6 EFA82813.1 - 8.1e-72 240.0 0.0 2.3e-71 238.5 0.0 1.8 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EFA82813.1 - 1.6e-11 44.5 6.4 1.7 9.7 0.0 7.4 7 0 0 7 7 7 3 WD domain, G-beta repeat HEAT PF02985.22 EFA82813.1 - 3e-09 36.3 4.4 0.03 14.6 0.1 6.1 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EFA82813.1 - 1.8e-05 24.8 0.0 0.00071 19.6 0.0 3.5 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA82813.1 - 8.2e-05 22.9 0.1 0.0025 18.2 0.0 2.9 2 1 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 EFA82813.1 - 0.0051 17.3 0.2 0.69 10.5 0.0 2.8 2 0 0 2 2 2 1 HEAT-like repeat Helitron_like_N PF14214.6 EFA82813.1 - 1.2 9.3 4.5 1.5 9.0 1.4 2.2 1 1 1 2 2 2 0 Helitron helicase-like domain at N-terminus LigB PF02900.18 EFA82814.1 - 1.6e-38 132.3 0.0 2e-38 132.0 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DUF758 PF05527.11 EFA82815.1 - 2.5e-35 122.1 2.2 3.9e-35 121.5 2.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF758) PH PF00169.29 EFA82815.1 - 1.1e-07 32.3 0.0 2.2e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 PH domain p450 PF00067.22 EFA82815.1 - 0.007 15.2 0.0 0.011 14.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_S20p PF01649.18 EFA82815.1 - 0.013 16.1 1.6 0.067 13.8 1.5 2.2 2 0 0 2 2 2 0 Ribosomal protein S20 PH_9 PF15410.6 EFA82815.1 - 0.014 15.8 0.8 0.073 13.4 0.6 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain DUF2715 PF10895.8 EFA82816.1 - 3.8e-09 36.4 43.2 0.00047 19.8 11.6 4.4 1 1 2 3 3 3 3 Domain of unknown function (DUF2715) MspA PF09203.11 EFA82816.1 - 3.8e-08 33.4 38.8 1.8e+04 -15.9 38.8 5.2 1 1 0 1 1 1 0 MspA PorP_SprF PF11751.8 EFA82816.1 - 9.3e-06 25.4 8.6 0.23 11.0 3.8 4.2 1 1 1 2 2 2 2 Type IX secretion system membrane protein PorP/SprF OMP_b-brl_2 PF13568.6 EFA82816.1 - 0.0021 18.1 36.7 18 5.3 5.6 7.8 1 1 2 3 3 3 2 Outer membrane protein beta-barrel domain Dicty_spore_N PF04562.12 EFA82817.1 - 2.3e-29 102.4 21.5 2.6e-29 102.2 21.5 1.0 1 0 0 1 1 1 1 Dictyostelium spore coat protein, N terminus HPHLAWLY PF14925.6 EFA82818.1 - 0.11 11.1 0.0 0.13 10.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function UFC1 PF08694.11 EFA82819.1 - 1.4 8.6 3.5 1.2 8.8 0.2 2.6 2 0 0 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 CinA_KH PF18146.1 EFA82819.1 - 1.6 8.9 5.8 4.9 7.4 0.3 4.0 2 1 1 3 3 3 0 Damage-inducible protein CinA KH domain NRN1 PF15056.6 EFA82819.1 - 4.8 7.4 7.5 1.9 8.6 0.2 3.9 2 1 3 5 5 5 0 Neuritin protein family Snf7 PF03357.21 EFA82820.1 - 8.2e-39 133.0 15.9 1.1e-38 132.6 15.9 1.0 1 0 0 1 1 1 1 Snf7 DUF1319 PF07028.11 EFA82820.1 - 0.00045 20.4 0.7 0.0011 19.2 0.2 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1319) Hydantoinase_B PF02538.14 EFA82820.1 - 0.0022 16.5 0.7 0.0027 16.2 0.7 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase RE_Bsp6I PF09504.10 EFA82820.1 - 0.0032 17.1 0.3 0.0063 16.1 0.2 1.5 1 1 0 1 1 1 1 Bsp6I restriction endonuclease Spc7 PF08317.11 EFA82820.1 - 0.0064 15.4 6.4 0.0081 15.1 6.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DNA_photolyase PF00875.18 EFA82820.1 - 0.025 14.6 0.2 0.037 14.0 0.2 1.2 1 0 0 1 1 1 0 DNA photolyase YvbH_ext PF11724.8 EFA82820.1 - 0.039 14.3 1.2 0.066 13.5 0.2 1.9 2 0 0 2 2 2 0 YvbH-like oligomerisation region LAT2 PF15703.5 EFA82820.1 - 0.042 13.7 2.8 0.061 13.2 2.8 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells family member 2 Endotoxin_N PF03945.14 EFA82820.1 - 0.049 13.3 2.6 0.11 12.2 2.6 1.5 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain TSC22 PF01166.18 EFA82820.1 - 0.19 12.0 2.6 11 6.5 0.1 2.9 3 1 0 3 3 3 0 TSC-22/dip/bun family Glutaredoxin PF00462.24 EFA82820.1 - 0.23 11.7 0.9 0.54 10.5 0.1 2.1 2 1 0 2 2 2 0 Glutaredoxin DUF848 PF05852.11 EFA82820.1 - 0.51 10.5 7.1 0.68 10.0 5.0 2.0 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) SlyX PF04102.12 EFA82820.1 - 4.5 8.0 12.8 8.9 7.0 0.0 3.6 2 1 0 3 3 3 0 SlyX Ribosomal_60s PF00428.19 EFA82821.1 - 4.3e-23 81.7 10.8 5.1e-23 81.5 10.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein BUD22 PF09073.10 EFA82821.1 - 0.005 16.2 0.4 0.0052 16.2 0.4 1.0 1 0 0 1 1 1 1 BUD22 AMP-binding PF00501.28 EFA82821.1 - 0.082 11.5 0.8 0.095 11.3 0.8 1.0 1 0 0 1 1 1 0 AMP-binding enzyme DUF3824 PF12868.7 EFA82821.1 - 0.098 13.3 4.6 0.17 12.6 4.6 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PepSY_2 PF13670.6 EFA82821.1 - 0.11 12.5 5.6 0.68 10.0 3.9 2.1 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain SpoVR PF04293.13 EFA82821.1 - 0.13 10.9 0.1 0.14 10.8 0.1 1.1 1 0 0 1 1 1 0 SpoVR like protein Proteasome PF00227.26 EFA82822.1 - 3.8e-13 49.3 0.0 7.8e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit Ndc1_Nup PF09531.10 EFA82822.1 - 0.051 12.3 7.6 0.079 11.6 7.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Med13_C PF06333.12 EFA82822.1 - 0.22 10.7 5.3 0.35 10.1 5.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Dapper PF15268.6 EFA82822.1 - 0.64 8.8 20.4 0.83 8.4 20.4 1.1 1 0 0 1 1 1 0 Dapper Presenilin PF01080.17 EFA82822.1 - 2.3 6.9 24.3 0.069 11.9 18.3 1.4 2 0 0 2 2 2 0 Presenilin Tmemb_14 PF03647.13 EFA82824.1 - 1.5e-24 86.5 12.2 1.7e-24 86.4 12.2 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C ABC2_membrane_3 PF12698.7 EFA82824.1 - 0.01 15.0 8.2 0.014 14.5 8.2 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein MerC PF03203.14 EFA82824.1 - 0.067 13.7 5.0 0.16 12.4 5.0 1.7 1 1 0 1 1 1 0 MerC mercury resistance protein CPP1-like PF11833.8 EFA82824.1 - 0.31 10.7 3.2 0.4 10.3 3.2 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Antimicrobial10 PF08105.11 EFA82824.1 - 0.66 10.1 3.4 2.1 8.5 0.1 2.6 1 1 1 2 2 2 0 Metchnikowin family Chromo PF00385.24 EFA82825.1 - 5.9e-12 45.3 1.3 5.9e-12 45.3 1.3 2.7 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain ABC2_membrane_2 PF12679.7 EFA82825.1 - 0.71 9.1 2.6 1.1 8.4 2.6 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein ANAPC8 PF04049.13 EFA82826.1 - 8.5e-26 90.7 1.6 8.5e-26 90.7 1.6 2.5 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 EFA82826.1 - 1.3e-23 81.8 33.1 1.4e-05 24.7 0.3 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFA82826.1 - 2.7e-19 67.7 37.4 0.0038 17.2 0.1 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 EFA82826.1 - 2.1e-16 58.7 33.3 0.0019 18.2 0.1 9.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFA82826.1 - 7.6e-13 48.1 12.3 0.054 14.3 0.1 7.6 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFA82826.1 - 3.9e-11 43.3 17.2 0.13 12.7 0.1 7.3 5 2 2 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFA82826.1 - 1.2e-10 41.6 23.1 0.00021 21.5 4.6 6.3 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFA82826.1 - 3.7e-09 36.0 18.2 0.0086 16.0 0.1 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA82826.1 - 1.1e-08 35.6 12.7 0.00017 22.1 0.1 6.6 5 1 1 7 7 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA82826.1 - 4e-07 30.0 7.6 0.0025 17.8 0.0 3.6 4 0 0 4 4 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EFA82826.1 - 5e-07 29.3 0.9 5e-07 29.3 0.9 5.3 5 1 1 6 6 6 2 TPR repeat zf-B_box PF00643.24 EFA82826.1 - 6.4e-07 29.4 10.3 1.4e-06 28.3 10.3 1.6 1 0 0 1 1 1 1 B-box zinc finger ANAPC3 PF12895.7 EFA82826.1 - 2.9e-05 24.2 38.1 0.0063 16.7 3.3 6.9 3 2 4 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFA82826.1 - 0.00024 20.9 14.5 1.6 8.7 0.0 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA82826.1 - 0.0019 18.4 19.3 0.12 12.8 0.1 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat DUF4508 PF14969.6 EFA82826.1 - 0.062 13.6 0.4 30 5.0 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4508) BTAD PF03704.17 EFA82826.1 - 0.3 11.5 3.4 0.26 11.7 0.3 2.5 3 0 0 3 3 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 EFA82826.1 - 4.9 8.0 24.5 28 5.6 0.0 8.4 9 1 1 10 10 10 0 Tetratricopeptide repeat BTB PF00651.31 EFA82827.1 - 8.6e-11 42.0 0.5 2.7e-10 40.5 0.5 1.9 1 0 0 1 1 1 1 BTB/POZ domain SPT2 PF08243.11 EFA82828.1 - 9.2e-20 71.2 30.5 9.2e-20 71.2 30.5 5.3 4 2 0 5 5 5 1 SPT2 chromatin protein F5_F8_type_C PF00754.25 EFA82829.1 - 1e-15 57.9 1.5 1.3e-15 57.7 1.5 1.1 1 0 0 1 1 1 1 F5/8 type C domain Arrestin_C PF02752.22 EFA82830.1 - 8.4e-16 58.6 0.1 3.9e-15 56.5 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain C2 PF00168.30 EFA82830.1 - 5.6e-15 55.5 0.1 1.3e-14 54.4 0.1 1.6 1 0 0 1 1 1 1 C2 domain SAM_1 PF00536.30 EFA82830.1 - 4.8e-12 46.1 1.4 5e-12 46.1 0.1 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA82830.1 - 9.3e-08 32.1 0.2 3e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Arrestin_N PF00339.29 EFA82830.1 - 9.4e-06 25.7 0.3 0.62 10.1 0.0 3.2 2 1 1 3 3 3 3 Arrestin (or S-antigen), N-terminal domain SAM_PNT PF02198.16 EFA82830.1 - 0.0013 18.7 0.1 0.0087 16.0 0.0 2.1 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Trs65 PF12735.7 EFA82830.1 - 0.0048 16.4 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Glyco_hydro_66 PF13199.6 EFA82830.1 - 0.072 11.7 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Fibrillarin PF01269.17 EFA82831.1 - 4.5e-99 330.2 0.1 5.2e-99 329.9 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EFA82831.1 - 0.00053 19.7 0.0 0.00081 19.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EFA82831.1 - 0.088 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EFA82831.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Na_Ca_ex PF01699.24 EFA82832.1 - 1.7e-09 37.8 27.9 3e-06 27.3 9.0 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein TFIIA PF03153.13 EFA82832.1 - 0.13 12.2 28.9 0.18 11.8 28.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3492 PF11997.8 EFA82832.1 - 4.5 6.9 6.4 1.2 8.8 2.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3492) ATAD4 PF15321.6 EFA82832.1 - 7.2 8.0 17.9 0.68 11.3 4.2 2.8 1 1 1 2 2 2 0 ATPase family AAA domain containing 4 SH3_2 PF07653.17 EFA82833.1 - 2.9e-13 49.3 0.0 4.5e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFA82833.1 - 1.8e-12 46.9 0.2 2.6e-12 46.4 0.2 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA82833.1 - 1.5e-10 40.5 0.2 2.2e-10 40.0 0.2 1.3 1 0 0 1 1 1 1 SH3 domain zinc_ribbon_2 PF13240.6 EFA82833.1 - 0.0019 17.8 4.2 0.0034 17.0 4.2 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EFA82833.1 - 0.0066 16.5 1.8 0.012 15.6 1.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-C3HC4_3 PF13920.6 EFA82833.1 - 0.023 14.5 1.2 0.038 13.9 1.2 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_L44 PF00935.19 EFA82834.1 - 1.5e-32 111.9 11.8 2.8e-32 111.0 11.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L44 PelD_GGDEF PF16963.5 EFA82835.1 - 0.061 13.1 0.5 0.089 12.6 0.5 1.3 1 0 0 1 1 1 0 PelD GGDEF domain CemA PF03040.14 EFA82835.1 - 0.21 11.5 1.6 0.26 11.2 1.5 1.3 1 1 0 1 1 1 0 CemA family TMF_DNA_bd PF12329.8 EFA82835.1 - 7.4 6.7 9.9 6.5 6.8 1.3 3.0 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Tetraspanin PF00335.20 EFA82836.1 - 5.9e-27 94.9 12.6 1.1e-26 93.9 12.6 1.4 1 0 0 1 1 1 1 Tetraspanin family Abhydrolase_1 PF00561.20 EFA82836.1 - 8.9e-20 71.4 0.9 1.8e-19 70.4 0.0 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA82836.1 - 1.5e-15 58.4 0.0 2.2e-15 57.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA82836.1 - 7e-13 48.4 0.0 1.2e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 FNIP PF05725.12 EFA82836.1 - 1.3e-07 31.7 10.9 0.00015 21.9 0.4 4.1 4 0 0 4 4 4 2 FNIP Repeat Ndr PF03096.14 EFA82836.1 - 0.049 12.3 0.0 0.13 10.9 0.0 1.6 1 0 0 1 1 1 0 Ndr family MSV199 PF10553.9 EFA82836.1 - 0.14 12.4 5.9 0.045 14.0 2.1 2.0 2 0 0 2 2 2 0 MSV199 domain HAD_2 PF13419.6 EFA82838.1 - 1.8e-14 54.2 1.5 4.4e-12 46.4 0.0 2.6 2 1 0 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFA82838.1 - 8.1e-11 42.6 0.0 2.2e-07 31.4 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA82838.1 - 4.5e-05 23.9 0.4 0.00074 20.0 0.4 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFA82838.1 - 0.00063 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like S6PP PF05116.13 EFA82838.1 - 0.00068 19.2 0.0 0.0018 17.8 0.0 1.7 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Acid_PPase PF12689.7 EFA82838.1 - 0.019 14.8 0.0 0.33 10.8 0.0 2.5 2 1 1 3 3 3 0 Acid Phosphatase Hydrolase_3 PF08282.12 EFA82838.1 - 0.029 14.1 1.5 4.4 6.9 0.0 3.1 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 EFA82838.1 - 0.048 13.3 0.0 6.3 6.4 0.0 2.5 3 0 0 3 3 3 0 Mitochondrial PGP phosphatase Abhydrolase_2 PF02230.16 EFA82839.1 - 0.00017 21.5 0.0 0.1 12.4 0.0 3.0 4 0 0 4 4 4 2 Phospholipase/Carboxylesterase Esterase_phd PF10503.9 EFA82839.1 - 0.014 14.9 0.9 3.4 7.1 0.1 3.6 3 1 1 4 4 4 0 Esterase PHB depolymerase Hydrolase_4 PF12146.8 EFA82839.1 - 0.044 13.1 0.0 1.5 8.1 0.0 2.6 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Arb2 PF09757.9 EFA82839.1 - 0.16 11.1 0.0 0.33 10.1 0.0 1.5 1 0 0 1 1 1 0 Arb2 domain DNA_topoisoIV PF00521.20 EFA82840.1 - 8e-107 357.8 18.6 8.4e-85 285.2 0.0 2.6 1 1 1 2 2 2 2 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFA82840.1 - 1.5e-46 157.8 2.3 1.5e-46 157.8 2.3 2.9 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFA82840.1 - 3.5e-24 85.2 1.7 1.1e-23 83.6 1.7 1.9 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EFA82840.1 - 1.1e-13 51.7 0.0 3e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EFA82840.1 - 5.1e-06 26.6 0.1 7.5e-05 22.9 0.0 3.0 2 0 0 2 2 2 1 Toprim domain PerC PF06069.11 EFA82840.1 - 0.0062 16.8 0.0 1.2 9.4 0.0 3.2 2 0 0 2 2 2 1 PerC transcriptional activator PARP PF00644.20 EFA82841.1 - 1.5e-15 57.3 1.7 2e-13 50.4 0.5 2.5 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain RelB PF04221.12 EFA82841.1 - 0.098 12.6 0.0 0.35 10.9 0.0 1.9 2 0 0 2 2 2 0 RelB antitoxin HSA PF07529.13 EFA82843.1 - 1.4 9.3 5.7 1.6 9.1 0.1 3.7 3 0 0 3 3 3 0 HSA BRCT_2 PF16589.5 EFA82844.1 - 0.00061 20.2 0.2 0.0065 16.9 0.0 3.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain DUF4277 PF14104.6 EFA82844.1 - 0.029 14.7 0.3 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4277) Glyco_hydro_10 PF00331.20 EFA82845.1 - 0.001 18.3 0.2 0.034 13.3 0.2 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 10 Glyco_hydro_39 PF01229.17 EFA82845.1 - 0.0034 16.0 0.0 0.0054 15.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 HMA PF00403.26 EFA82846.1 - 3.3e-05 24.2 0.1 0.00016 22.1 0.0 2.2 2 0 0 2 2 2 1 Heavy-metal-associated domain Arm_2 PF04826.13 EFA82846.1 - 4.2e-05 23.1 4.1 4.2e-05 23.1 4.1 1.6 2 0 0 2 2 2 1 Armadillo-like Arm PF00514.23 EFA82846.1 - 0.00015 21.6 0.0 0.00044 20.2 0.0 1.8 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Cornichon PF03311.14 EFA82847.1 - 1.3e-10 41.6 2.5 1.6e-10 41.3 2.5 1.1 1 0 0 1 1 1 1 Cornichon protein Amastin PF07344.11 EFA82847.1 - 0.0071 16.2 0.0 0.0076 16.1 0.0 1.1 1 0 0 1 1 1 1 Amastin surface glycoprotein adh_short PF00106.25 EFA82848.1 - 9e-41 139.5 0.7 1.6e-32 112.5 0.7 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA82848.1 - 2.3e-31 109.1 0.2 6.8e-24 84.7 0.3 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA82848.1 - 3.5e-09 36.8 0.1 6.4e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA82848.1 - 1.4e-06 28.0 0.4 7.3e-06 25.6 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFA82848.1 - 0.00049 19.6 0.6 0.0021 17.5 0.1 2.1 2 1 1 3 3 3 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFA82848.1 - 0.031 14.6 2.0 0.18 12.1 0.2 2.6 3 1 1 4 4 4 0 Saccharopine dehydrogenase NADP binding domain ORC3_N PF07034.11 EFA82849.1 - 1.2e-24 87.0 10.8 8.6e-24 84.2 0.2 3.5 3 0 0 3 3 3 2 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EFA82849.1 - 5.9e-11 42.6 0.0 5.9e-11 42.6 0.0 5.5 4 2 0 4 4 4 1 Origin recognition complex winged helix C-terminal CBM49 PF09478.10 EFA82850.1 - 1.1e-16 60.9 0.2 1.5e-16 60.4 0.2 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 D123 PF07065.14 EFA82851.1 - 1.3e-92 310.3 12.6 1.7e-92 309.8 12.6 1.1 1 0 0 1 1 1 1 D123 R2K_2 PF18299.1 EFA82851.1 - 0.041 13.8 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 NOA36 PF06524.12 EFA82851.1 - 1.1 8.6 10.8 1.6 8.0 10.8 1.2 1 0 0 1 1 1 0 NOA36 protein PfkB PF00294.24 EFA82852.1 - 7.3e-48 163.4 1.1 9e-48 163.1 1.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Sulfotransfer_1 PF00685.27 EFA82853.1 - 1.3e-16 60.9 0.1 4.2e-16 59.2 0.1 1.8 1 1 0 1 1 1 1 Sulfotransferase domain Glyco_trans_1_4 PF13692.6 EFA82853.1 - 2.4e-12 47.4 0.0 5.9e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EFA82853.1 - 3.3e-12 46.3 0.0 6.7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFA82853.1 - 1.1e-08 35.3 0.5 6.5e-08 32.8 0.1 2.5 3 0 0 3 3 3 1 Glycosyltransferase Family 4 Sulfotransfer_3 PF13469.6 EFA82853.1 - 1.9e-08 35.0 0.8 3.2e-05 24.4 0.8 3.2 1 1 0 1 1 1 1 Sulfotransferase family Glyco_transf_5 PF08323.11 EFA82853.1 - 7.4e-06 25.8 0.1 2.2e-05 24.3 0.1 1.8 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 EFA82853.1 - 2.9e-05 24.6 0.0 0.00011 22.7 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain DIOX_N PF14226.6 EFA82854.1 - 1.3e-08 35.6 0.0 3e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal PM0188 PF11477.8 EFA82854.1 - 0.012 14.8 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Sialyltransferase PMO188 Gln-synt_C PF00120.24 EFA82855.1 - 2e-245 813.0 0.0 3.4e-83 279.5 0.0 3.1 3 0 0 3 3 3 3 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 EFA82855.1 - 0.00045 20.0 0.0 0.011 15.6 0.0 3.0 3 1 0 3 3 3 1 Glutamine synthetase N-terminal domain GCS2 PF04107.13 EFA82855.1 - 0.083 12.2 0.0 7.7 5.8 0.0 3.4 3 1 1 4 4 4 0 Glutamate-cysteine ligase family 2(GCS2) Oxysterol_BP PF01237.18 EFA82858.1 - 1.6e-49 168.8 10.4 5.9e-47 160.3 10.4 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein FAM60A PF15396.6 EFA82858.1 - 1 9.3 6.6 10 6.1 0.2 2.6 2 1 0 2 2 2 0 Protein Family FAM60A VIT PF08487.10 EFA82859.1 - 2.5e-40 137.1 0.0 6.4e-40 135.8 0.0 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain PARP PF00644.20 EFA82859.1 - 6.9e-28 97.6 1.8 5.1e-27 94.7 1.8 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain 14-3-3 PF00244.20 EFA82859.1 - 7.5e-22 77.9 4.4 7.5e-22 77.9 4.4 2.3 2 0 0 2 2 2 1 14-3-3 protein VWA_3 PF13768.6 EFA82859.1 - 5.1e-17 62.2 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EFA82859.1 - 3.3e-13 49.3 0.0 7.9e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EFA82859.1 - 5.3e-12 46.3 0.0 1.7e-11 44.7 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA82859.1 - 1.9e-09 38.2 0.0 8.5e-09 36.0 0.0 2.3 1 0 0 1 1 1 1 von Willebrand factor type A domain BRCT PF00533.26 EFA82859.1 - 0.00015 22.1 0.0 0.00048 20.5 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA82859.1 - 0.027 14.9 2.6 0.035 14.5 0.1 2.6 3 0 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain PUF PF00806.19 EFA82860.1 - 1.2e-06 27.9 1.6 0.0089 15.7 0.0 4.3 4 0 0 4 4 4 2 Pumilio-family RNA binding repeat zf-CCHC PF00098.23 EFA82861.1 - 1.3e-39 132.5 39.4 1.1e-07 31.6 2.5 5.7 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_3 PF13917.6 EFA82861.1 - 7.6e-07 29.0 23.5 0.65 10.0 0.7 5.4 3 1 2 5 5 5 5 Zinc knuckle zf-CCHC_2 PF13696.6 EFA82861.1 - 0.0013 18.5 38.2 1.2 9.0 1.0 5.6 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_4 PF14392.6 EFA82861.1 - 0.21 11.3 25.7 7.9 6.3 0.5 5.3 5 0 0 5 5 5 0 Zinc knuckle TRAF6_Z2 PF18048.1 EFA82861.1 - 1.3 9.2 25.2 20 5.4 0.4 5.9 6 0 0 6 6 6 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_assoc PF16606.5 EFA82861.1 - 5.2 7.3 18.2 8.4 6.7 2.2 4.3 2 2 2 4 4 4 0 Unstructured conserved, between two C2H2-type zinc-fingers HRM PF02793.22 EFA82861.1 - 7 7.0 16.1 10 6.5 1.3 3.4 2 1 1 3 3 3 0 Hormone receptor domain zf-CCHC_5 PF14787.6 EFA82861.1 - 8.7 6.1 28.0 25 4.7 0.7 5.5 5 0 0 5 5 5 0 GAG-polyprotein viral zinc-finger SRP19 PF01922.17 EFA82862.1 - 1.1e-27 96.8 0.0 1.6e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein CTV_P23 PF04808.12 EFA82863.1 - 0.085 12.4 0.6 0.083 12.4 0.6 1.0 1 0 0 1 1 1 0 Citrus tristeza virus (CTV) P23 protein DUF4013 PF13197.6 EFA82864.1 - 0.001 18.9 3.5 0.0013 18.5 3.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4013) DUF2970 PF11174.8 EFA82864.1 - 0.0046 16.8 0.6 0.0046 16.8 0.6 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2970) Lys_export PF03956.13 EFA82864.1 - 0.0047 16.5 0.5 0.0056 16.2 0.5 1.1 1 0 0 1 1 1 1 Lysine exporter LysO DUF2207 PF09972.9 EFA82864.1 - 0.024 13.4 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MIG-14_Wnt-bd PF06664.12 EFA82864.1 - 0.024 13.8 2.0 0.031 13.5 2.0 1.1 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion EphA2_TM PF14575.6 EFA82864.1 - 0.036 15.0 0.0 0.45 11.4 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Cytomega_TRL10 PF06084.11 EFA82864.1 - 0.13 12.2 1.8 0.27 11.3 0.2 2.0 1 1 1 2 2 2 0 Cytomegalovirus TRL10 protein ODV-E18 PF10717.9 EFA82864.1 - 3.8 7.4 6.4 1.2 9.1 2.6 2.1 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Sigma_reg_N PF13800.6 EFA82864.1 - 6.7 7.1 8.7 1.6 9.1 2.8 2.3 2 1 0 2 2 2 0 Sigma factor regulator N-terminal Pkinase PF00069.25 EFA82865.1 - 3.2e-49 167.7 0.7 3.2e-49 167.7 0.7 3.6 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82865.1 - 2.9e-20 72.7 6.7 6.5e-19 68.2 0.2 3.9 3 1 0 3 3 3 2 Protein tyrosine kinase FKBP_C PF00254.28 EFA82866.1 - 2.9e-33 114.1 0.0 3.6e-33 113.7 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_C PF00254.28 EFA82867.1 - 5.3e-12 45.9 0.0 5.7e-12 45.8 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_C PF00254.28 EFA82868.1 - 7.3e-18 64.7 0.0 8.3e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_C PF00254.28 EFA82869.1 - 3e-33 114.0 0.1 3.5e-33 113.8 0.1 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_C PF00254.28 EFA82870.1 - 1.7e-19 69.9 0.0 4.7e-19 68.5 0.0 1.8 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Epimerase PF01370.21 EFA82871.1 - 2.5e-19 69.7 0.3 2.7e-11 43.4 0.0 2.4 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFA82871.1 - 1.5e-12 47.3 0.3 2.3e-05 23.7 0.1 3.2 2 1 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EFA82871.1 - 2.4e-12 46.5 2.4 1.4e-07 30.9 0.0 3.1 2 1 1 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFA82871.1 - 7.3e-12 45.3 1.8 0.018 14.5 0.0 4.1 3 1 0 3 3 3 3 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFA82871.1 - 1.3e-06 27.8 0.1 0.00029 20.0 0.0 2.9 2 1 0 2 2 2 1 RmlD substrate binding domain CDC45 PF02724.14 EFA82871.1 - 0.0072 14.7 0.3 0.0085 14.4 0.3 1.1 1 0 0 1 1 1 1 CDC45-like protein NAD_binding_10 PF13460.6 EFA82871.1 - 0.016 15.1 0.1 5.2 6.9 0.0 2.9 4 0 0 4 4 4 0 NAD(P)H-binding Macoilin PF09726.9 EFA82871.1 - 0.04 12.5 5.5 0.068 11.7 5.5 1.3 1 0 0 1 1 1 0 Macoilin family TEX19 PF15553.6 EFA82871.1 - 0.23 11.4 0.1 0.41 10.6 0.1 1.3 1 0 0 1 1 1 0 Testis-expressed protein 19 Presenilin PF01080.17 EFA82871.1 - 0.37 9.5 1.9 0.63 8.7 1.9 1.3 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.10 EFA82871.1 - 1 8.6 10.3 1.5 8.1 10.3 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EFA82871.1 - 2.3 6.3 6.3 3.3 5.8 6.3 1.1 1 0 0 1 1 1 0 Nop14-like family Menin PF05053.13 EFA82871.1 - 7.1 4.9 8.3 11 4.2 8.3 1.2 1 0 0 1 1 1 0 Menin DUF4871 PF16167.5 EFA82875.1 - 0.019 15.0 1.8 0.025 14.6 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4871) SecB PF02556.14 EFA82875.1 - 0.039 13.8 0.3 0.045 13.6 0.3 1.1 1 0 0 1 1 1 0 Preprotein translocase subunit SecB ATP11 PF06644.11 EFA82875.1 - 0.07 12.9 2.1 0.073 12.9 2.1 1.0 1 0 0 1 1 1 0 ATP11 protein Miga PF10265.9 EFA82875.1 - 0.23 10.4 2.9 0.24 10.4 2.9 1.0 1 0 0 1 1 1 0 Mitoguardin BRCT_2 PF16589.5 EFA82876.1 - 0.00017 21.9 3.8 0.001 19.4 0.0 3.9 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain Yop-YscD_cpl PF16697.5 EFA82876.1 - 0.18 12.1 0.0 0.45 10.9 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain THF_DHG_CYH_C PF02882.19 EFA82877.1 - 5.2e-71 237.1 4.2 9.3e-71 236.3 4.2 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EFA82877.1 - 5e-36 123.5 0.5 8.1e-36 122.8 0.5 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 EFA82877.1 - 0.002 17.1 0.3 0.0028 16.6 0.3 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Nepo_coat_N PF03689.15 EFA82877.1 - 0.15 12.0 0.1 6.5 6.8 0.1 2.4 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Med13_C PF06333.12 EFA82878.1 - 0.0004 19.8 3.8 0.00046 19.6 3.8 1.1 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain zf-BED PF02892.15 EFA82878.1 - 0.0009 19.2 2.3 0.0017 18.3 2.3 1.4 1 0 0 1 1 1 1 BED zinc finger Xpo1 PF08389.12 EFA82882.1 - 6.8e-40 136.5 1.7 6.8e-40 136.5 1.7 5.3 6 1 0 6 6 6 1 Exportin 1-like protein TFIIA PF03153.13 EFA82883.1 - 0.1 12.6 35.9 0.12 12.4 35.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 EFA82883.1 - 0.35 10.2 22.2 0.46 9.8 22.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) L_lactis_ph-MCP PF06673.11 EFA82883.1 - 3.6 6.5 9.6 5.8 5.8 9.6 1.3 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein Asp-B-Hydro_N PF05279.11 EFA82883.1 - 8.6 6.3 27.0 11 6.0 27.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TRAP-gamma PF07074.12 EFA82884.1 - 1.1e-30 106.4 12.0 1.3e-30 106.2 12.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF3487 PF11990.8 EFA82884.1 - 1.2 9.0 4.4 0.27 11.1 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) SpoIIM PF01944.17 EFA82884.1 - 5.1 7.1 13.9 0.31 11.1 2.5 2.0 1 1 1 2 2 2 0 Stage II sporulation protein M MCM_bind PF09739.9 EFA82885.1 - 1.3e-126 423.5 22.8 3.3e-102 342.9 15.5 2.1 1 1 1 2 2 2 2 Mini-chromosome maintenance replisome factor FNIP PF05725.12 EFA82885.1 - 2.9e-41 139.4 8.3 6.8e-11 42.2 0.0 7.6 6 2 1 7 7 7 5 FNIP Repeat Presenilin PF01080.17 EFA82885.1 - 0.46 9.2 9.0 0.85 8.3 9.0 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EFA82885.1 - 5.6 5.4 18.7 0.079 11.5 11.4 1.5 2 0 0 2 2 2 0 Macoilin family VASt PF16016.5 EFA82887.1 - 7.3e-16 58.9 0.5 7.3e-16 58.9 0.5 2.3 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain CBM49 PF09478.10 EFA82887.1 - 1.1e-11 44.8 0.0 3.7e-11 43.2 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Macoilin PF09726.9 EFA82887.1 - 0.03 12.9 27.2 0.053 12.1 27.2 1.3 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 EFA82887.1 - 0.53 9.6 9.6 13 5.1 7.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Mucin PF01456.17 EFA82887.1 - 1.4 8.9 6.5 6.4 6.8 6.1 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein Androgen_recep PF02166.16 EFA82887.1 - 8.6 5.1 13.9 2.7 6.8 5.6 2.1 2 0 0 2 2 2 0 Androgen receptor Myb_DNA-bind_6 PF13921.6 EFA82888.1 - 2.9e-13 49.8 5.9 9.8e-12 44.9 5.6 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFA82888.1 - 1.2e-10 41.4 1.9 1.2e-05 25.4 0.2 3.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFA82888.1 - 0.005 17.0 2.6 0.084 13.1 0.3 2.7 1 1 1 2 2 2 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_5 PF13873.6 EFA82888.1 - 0.33 11.0 7.2 13 6.0 0.0 4.1 2 1 2 4 4 4 0 Myb/SANT-like DNA-binding domain Ank_2 PF12796.7 EFA82890.1 - 2.1e-15 57.1 3.9 3.4e-07 30.8 0.0 5.7 2 2 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82890.1 - 2.5e-12 47.0 4.7 0.037 14.6 0.0 7.7 5 2 3 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82890.1 - 1.2e-09 37.5 0.2 6.8 7.6 0.0 9.2 10 0 0 10 10 10 1 Ankyrin repeat Ank_5 PF13857.6 EFA82890.1 - 1.5e-08 34.7 0.2 0.16 12.3 0.0 6.2 6 2 2 8 8 8 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA82890.1 - 0.0038 17.6 2.8 63 4.3 0.0 5.6 5 1 1 6 6 6 0 Ankyrin repeat DUF3447 PF11929.8 EFA82890.1 - 0.023 14.6 2.0 8.4 6.4 0.6 4.3 5 1 0 5 5 5 0 Domain of unknown function (DUF3447) G-alpha PF00503.20 EFA82892.1 - 9.2e-103 344.1 10.6 1.1e-102 343.8 10.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA82892.1 - 1.3e-13 50.8 0.6 3.9e-09 36.2 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA82892.1 - 0.007 16.4 0.1 3.1 7.9 0.0 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase Roc PF08477.13 EFA82892.1 - 0.018 15.2 0.0 8.2 6.7 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA82892.1 - 0.025 14.0 0.1 2.1 7.7 0.0 2.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Importin_rep_6 PF18829.1 EFA82892.1 - 0.05 13.7 1.9 0.11 12.7 0.1 2.3 2 1 0 3 3 3 0 Importin repeat 6 MCM PF00493.23 EFA82892.1 - 0.072 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain GTP_EFTU PF00009.27 EFA82892.1 - 0.083 12.4 0.5 0.37 10.3 0.3 2.2 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain PIF1 PF05970.14 EFA82893.1 - 1.3e-51 175.9 0.2 7.6e-36 124.0 0.0 3.7 2 2 2 4 4 3 2 PIF1-like helicase AAA_30 PF13604.6 EFA82893.1 - 1.2e-16 61.0 0.0 6.3e-16 58.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain U-box PF04564.15 EFA82893.1 - 3.5e-13 49.5 0.8 2.1e-12 47.0 0.1 2.8 2 0 0 2 2 2 1 U-box domain AAA_19 PF13245.6 EFA82893.1 - 3.3e-09 37.2 0.0 8e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFA82893.1 - 3.7e-06 27.4 0.0 1e-05 26.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFA82893.1 - 3.3e-05 23.9 1.1 0.00085 19.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFA82893.1 - 9e-05 22.3 0.3 0.0011 18.8 0.0 2.7 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_7 PF12775.7 EFA82893.1 - 0.00018 21.0 0.1 0.00047 19.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EFA82893.1 - 0.00028 20.7 4.9 0.081 12.7 0.1 3.8 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EFA82893.1 - 0.00038 20.9 0.0 0.00082 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFA82893.1 - 0.00054 20.3 0.0 0.0019 18.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFA82893.1 - 0.0015 17.7 0.1 0.0027 16.8 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.15 EFA82893.1 - 0.0015 18.4 0.4 0.054 13.4 0.2 2.5 2 0 0 2 2 2 1 NTPase AAA_24 PF13479.6 EFA82893.1 - 0.0025 17.5 0.0 0.0082 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFA82893.1 - 0.012 15.6 0.1 0.012 15.6 0.1 3.5 3 2 0 3 3 2 0 ATPase domain predominantly from Archaea UvrD_C_2 PF13538.6 EFA82893.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_33 PF13671.6 EFA82893.1 - 0.22 11.7 0.8 1.8 8.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA82893.1 - 0.24 11.9 0.1 0.24 11.9 0.1 4.0 4 1 0 4 4 3 0 ABC transporter Helicase_RecD PF05127.14 EFA82893.1 - 0.24 11.2 5.0 1.1 9.1 0.1 3.3 2 1 0 2 2 2 0 Helicase Phage_Gp23 PF10669.9 EFA82893.1 - 0.29 11.5 3.1 1.2 9.5 3.1 2.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) TFIIA PF03153.13 EFA82894.1 - 0.0063 16.6 35.7 0.0076 16.3 35.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SOG2 PF10428.9 EFA82894.1 - 0.035 13.3 26.3 0.044 13.0 26.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF5600 PF18150.1 EFA82894.1 - 0.05 14.2 0.2 0.17 12.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5600) Hid1 PF12722.7 EFA82894.1 - 0.12 10.5 16.2 0.14 10.3 16.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF966 PF06136.13 EFA82894.1 - 0.28 10.9 18.0 0.34 10.6 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Macoilin PF09726.9 EFA82894.1 - 3.7 6.0 15.4 4.3 5.8 15.4 1.1 1 0 0 1 1 1 0 Macoilin family DEAD PF00270.29 EFA82896.1 - 1.4e-40 139.0 0.0 3.6e-40 137.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA82896.1 - 3.1e-28 98.3 0.0 1.5e-26 92.9 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFA82896.1 - 0.11 12.8 0.1 0.49 10.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain Clat_adaptor_s PF01217.20 EFA82899.1 - 8.2e-35 119.8 4.7 1.4e-34 119.1 4.7 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Profilin PF00235.19 EFA82900.1 - 2.1e-08 34.5 0.0 2.6e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Profilin BRCT PF00533.26 EFA82901.1 - 2e-05 24.8 0.1 8.9e-05 22.8 0.1 2.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA82901.1 - 5.1e-05 23.6 0.0 0.0003 21.1 0.0 2.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFA82901.1 - 0.00054 19.8 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain RRM_1 PF00076.22 EFA82901.1 - 0.0081 16.0 0.6 0.035 13.9 0.6 2.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA82901.1 - 0.01 15.8 0.5 0.025 14.6 0.3 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DNA_ligase_A_M PF01068.21 EFA82903.1 - 0.018 14.7 0.5 0.027 14.1 0.2 1.5 1 1 0 1 1 1 0 ATP dependent DNA ligase domain TPR_17 PF13431.6 EFA82904.1 - 2.9e-110 353.0 5.1 2.3e-10 40.1 0.0 10.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_11 PF13414.6 EFA82904.1 - 1.9e-13 49.8 22.6 0.26 11.0 0.1 9.7 10 0 0 10 10 10 5 TPR repeat NleF_casp_inhib PF16809.5 EFA82904.1 - 2.6e-06 27.4 4.4 20 5.1 0.0 7.5 2 2 7 9 9 9 0 NleF caspase inhibitor Lyx_isomer PF07385.12 EFA82904.1 - 0.00014 21.2 8.5 22 4.2 0.0 7.8 2 2 6 9 9 9 0 D-lyxose isomerase Glyco_hydro_61 PF03443.14 EFA82904.1 - 0.00038 20.4 8.1 54 3.6 0.4 7.3 4 2 3 7 7 7 0 Glycosyl hydrolase family 61 Anth_Ig PF05587.13 EFA82904.1 - 0.002 18.4 11.3 40 4.6 0.0 7.3 9 0 0 9 9 9 0 Anthrax receptor extracellular domain Ntox46 PF15538.6 EFA82904.1 - 0.0021 18.1 3.9 40 4.1 0.0 6.0 2 1 6 8 8 8 0 Bacterial toxin 46 PLAT PF01477.23 EFA82904.1 - 0.0024 18.4 1.8 68 4.1 0.0 5.0 1 1 4 6 6 6 0 PLAT/LH2 domain DUF3431 PF11913.8 EFA82904.1 - 0.0025 17.6 1.2 15 5.3 0.0 3.8 1 1 4 5 5 5 0 Protein of unknown function (DUF3431) Tudor_RapA PF18337.1 EFA82904.1 - 0.011 15.9 7.5 12 6.2 0.0 6.9 8 0 0 8 8 8 0 RapA N-terminal Tudor like domain DUF1153 PF06627.11 EFA82904.1 - 0.015 15.4 0.0 60 3.9 0.0 5.8 9 0 0 9 9 9 0 Protein of unknown function (DUF1153) Str_synth PF03088.16 EFA82904.1 - 0.038 14.1 0.5 14 5.9 0.0 4.8 5 3 1 6 6 6 0 Strictosidine synthase FANCI_HD1 PF14679.6 EFA82904.1 - 0.049 13.6 0.0 3.5e+02 1.3 0.0 5.3 6 1 1 7 7 7 0 FANCI helical domain 1 P22_CoatProtein PF11651.8 EFA82904.1 - 0.088 11.4 0.4 7.8 5.0 0.0 3.8 2 1 5 7 7 7 0 P22 coat protein - gene protein 5 DUF1344 PF07076.11 EFA82904.1 - 0.52 10.2 6.1 6.8 6.7 0.0 5.4 9 0 0 9 9 9 0 Protein of unknown function (DUF1344) DUF775 PF05603.12 EFA82905.1 - 0.16 11.5 1.7 0.44 10.0 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF775) Mer2 PF09074.10 EFA82905.1 - 0.37 10.6 7.6 1.7 8.4 0.5 2.0 1 1 1 2 2 2 0 Mer2 Asp-B-Hydro_N PF05279.11 EFA82905.1 - 0.7 9.9 9.0 0.78 9.8 9.0 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AAA_11 PF13086.6 EFA82905.1 - 1.5 8.6 8.8 1.7 8.4 8.8 1.1 1 0 0 1 1 1 0 AAA domain Fzo_mitofusin PF04799.13 EFA82905.1 - 6.4 6.3 8.5 1.8 8.1 2.5 2.0 1 1 1 2 2 2 0 fzo-like conserved region FAM25 PF15825.5 EFA82906.1 - 0.34 11.3 8.6 5.4 7.4 8.6 2.3 1 1 0 1 1 1 0 FAM25 family CAP_N PF01213.19 EFA82907.1 - 3.6e-100 335.5 1.6 5.1e-100 335.0 1.6 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EFA82907.1 - 8.4e-64 213.9 8.7 1.2e-63 213.5 8.7 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EFA82907.1 - 0.00015 21.5 5.8 0.0011 18.7 5.7 2.1 1 1 0 1 1 1 1 Tubulin binding cofactor C Hemerythrin PF01814.23 EFA82907.1 - 0.12 13.0 0.1 0.87 10.2 0.0 2.1 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain VIR_N PF15912.5 EFA82907.1 - 0.69 9.5 4.2 1.1 8.7 4.2 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Tetraspanin PF00335.20 EFA82908.1 - 0.15 11.7 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 Tetraspanin family Peptidase_M16 PF00675.20 EFA82909.1 - 2.3e-53 180.2 0.1 4e-53 179.4 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFA82909.1 - 4e-32 111.7 0.0 1.3e-31 110.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 EFA82909.1 - 0.012 14.7 0.1 0.019 14.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase M16C associated RhoGAP PF00620.27 EFA82910.1 - 6.3e-34 117.0 1.6 1.6e-33 115.7 0.3 2.4 2 0 0 2 2 2 1 RhoGAP domain RhoGEF PF00621.20 EFA82910.1 - 5.9e-32 111.4 3.2 6.1e-32 111.3 0.4 2.5 3 0 0 3 3 3 1 RhoGEF domain SdrD_B PF17210.3 EFA82910.1 - 2.8e-07 30.7 0.1 2.8e-07 30.7 0.1 2.4 3 0 0 3 3 3 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA82910.1 - 0.0011 19.2 0.0 0.0042 17.3 0.0 2.0 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain PH PF00169.29 EFA82910.1 - 0.0035 17.8 1.7 0.0083 16.6 0.4 2.3 2 0 0 2 2 2 1 PH domain IQ PF00612.27 EFA82910.1 - 0.032 14.0 0.3 0.083 12.7 0.3 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Roughex PF06020.11 EFA82910.1 - 0.48 9.5 3.4 1.4 7.9 1.9 2.3 2 0 0 2 2 2 0 Drosophila roughex protein DUF3381 PF11861.8 EFA82910.1 - 3.2 7.5 7.0 1.3 8.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DEAD PF00270.29 EFA82911.1 - 4.6e-46 156.8 0.0 9.4e-46 155.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA82911.1 - 4.2e-26 91.5 0.0 2.8e-25 88.8 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFA82911.1 - 3.4e-19 68.8 0.4 5.8e-19 68.1 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Macoilin PF09726.9 EFA82911.1 - 0.035 12.7 7.0 0.046 12.3 7.0 1.1 1 0 0 1 1 1 0 Macoilin family PNPase PF03726.14 EFA82911.1 - 1.2 9.7 5.5 1.1 9.8 3.1 2.2 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF3439 PF11921.8 EFA82911.1 - 5.9 6.9 12.8 14 5.7 12.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TIG PF01833.24 EFA82912.1 - 3.1e-18 65.6 35.7 3.9e-06 26.9 4.5 5.7 5 1 1 6 6 6 5 IPT/TIG domain DUF3290 PF11694.8 EFA82912.1 - 0.0017 18.3 4.9 0.17 11.8 0.1 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3290) CD20 PF04103.15 EFA82912.1 - 0.0031 17.6 0.2 0.023 14.8 0.0 2.5 3 0 0 3 3 3 1 CD20-like family DNA_pol3_a_NII PF11490.8 EFA82912.1 - 0.0064 16.4 0.3 0.019 14.9 0.3 1.8 1 0 0 1 1 1 1 DNA polymerase III polC-type N-terminus II Pex24p PF06398.11 EFA82913.1 - 0.00081 18.5 1.9 0.00097 18.2 1.9 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Pex14_N PF04695.13 EFA82913.1 - 0.032 14.9 1.3 0.052 14.2 1.3 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RIC3 PF15361.6 EFA82913.1 - 0.035 14.5 0.1 0.052 13.9 0.1 1.4 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF2722 PF10846.8 EFA82913.1 - 2.9 6.7 12.6 3.6 6.4 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Hexapep PF00132.24 EFA82914.1 - 7.5e-05 22.3 3.6 1.3 8.9 0.1 4.1 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) DFRP_C PF16543.5 EFA82915.1 - 2.1e-21 76.2 7.2 2.1e-21 76.2 7.2 4.8 3 2 1 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 EFA82915.1 - 2.8e-06 27.0 8.9 8.2e-06 25.5 1.1 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EFA82915.1 - 6.8e-06 25.9 0.8 6.8e-06 25.9 0.8 3.0 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA82915.1 - 9.7e-06 25.5 6.0 9.7e-06 25.5 6.0 3.2 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 EFA82915.1 - 5.3e-05 23.9 18.1 8.1e-05 23.3 5.2 4.0 2 1 1 3 3 3 2 Torus domain zf-CCCH_3 PF15663.5 EFA82915.1 - 0.021 15.0 0.3 0.021 15.0 0.3 3.2 2 1 0 3 3 3 0 Zinc-finger containing family YL1 PF05764.13 EFA82915.1 - 0.025 14.7 0.6 0.025 14.7 0.6 3.8 2 1 0 3 3 3 0 YL1 nuclear protein zf-CCCH_2 PF14608.6 EFA82915.1 - 0.27 11.8 12.7 0.96 10.0 5.0 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger MaoC_dehydratas PF01575.19 EFA82916.1 - 3.3e-31 107.4 0.0 6.3e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EFA82916.1 - 3.5e-06 27.2 0.0 0.00021 21.4 0.0 2.6 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase HgmA PF04209.13 EFA82917.1 - 1.9e-214 712.1 0.1 2.2e-214 711.9 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase PhoR PF11808.8 EFA82918.1 - 0.31 11.5 7.3 0.28 11.6 4.8 2.2 1 1 1 2 2 2 0 Phosphate regulon sensor protein PhoR Mucin PF01456.17 EFA82918.1 - 6.4 6.8 20.8 0.095 12.7 4.2 2.7 3 0 0 3 3 3 0 Mucin-like glycoprotein Ceramidase_alk PF04734.13 EFA82919.1 - 8.4e-215 714.2 0.0 1e-214 713.9 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EFA82919.1 - 8.7e-44 149.4 0.1 1.3e-43 148.8 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Peptidase_M20 PF01546.28 EFA82919.1 - 4.5e-37 127.8 0.0 8.7e-37 126.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA82919.1 - 1.2e-11 44.4 0.0 2.5e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain zf-HIT PF04438.16 EFA82920.1 - 4.4e-07 29.7 12.3 6.8e-07 29.0 12.3 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 EFA82920.1 - 0.0008 19.5 10.3 0.0012 18.8 10.3 1.3 1 0 0 1 1 1 1 MYND finger RE_AlwI PF09491.10 EFA82920.1 - 0.00096 18.1 7.8 0.0011 17.9 7.8 1.0 1 0 0 1 1 1 1 AlwI restriction endonuclease Secretin_N_2 PF07655.13 EFA82920.1 - 0.017 15.6 10.1 0.028 14.9 10.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain CEBP_ZZ PF16366.5 EFA82920.1 - 0.028 14.6 5.1 0.045 14.0 5.1 1.3 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Pyridoxal_deC PF00282.19 EFA82921.1 - 4.2e-17 61.9 0.0 8e-17 61.0 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EFA82921.1 - 1.9e-14 53.4 0.3 1.1e-13 51.0 0.3 2.1 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFA82921.1 - 4.1e-08 32.8 0.3 9.8e-06 25.0 0.1 2.7 3 0 0 3 3 3 2 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EFA82921.1 - 0.00043 19.7 0.4 0.00078 18.8 0.4 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SCO1-SenC PF02630.14 EFA82921.1 - 0.12 12.3 1.1 0.45 10.4 0.5 2.1 2 0 0 2 2 2 0 SCO1/SenC DUF3439 PF11921.8 EFA82921.1 - 0.55 10.2 6.1 1.2 9.1 6.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AAA_7 PF12775.7 EFA82922.1 - 1.3e-08 34.5 3.4 0.0065 16.0 0.1 5.2 4 1 0 4 4 4 2 P-loop containing dynein motor region AAA PF00004.29 EFA82922.1 - 7.5e-08 32.9 3.0 6.4e-06 26.6 0.0 5.0 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFA82922.1 - 0.00011 22.5 0.0 2.3 8.5 0.0 4.5 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EFA82922.1 - 0.0034 17.4 0.0 34 4.4 0.0 4.7 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA82922.1 - 0.014 15.8 0.0 8.9 6.7 0.0 4.1 4 0 0 4 4 4 0 AAA ATPase domain THP2 PF09432.10 EFA82922.1 - 0.016 15.2 7.0 0.38 10.8 0.6 4.7 4 0 0 4 4 4 0 Tho complex subunit THP2 T2SSE PF00437.20 EFA82922.1 - 0.025 13.7 0.1 0.37 9.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein ABC_tran PF00005.27 EFA82922.1 - 0.3 11.6 4.9 6.7 7.2 0.0 4.5 5 0 0 5 5 5 0 ABC transporter DUF5347 PF17282.2 EFA82922.1 - 0.35 11.2 7.1 14 6.1 0.0 5.4 4 0 0 4 4 4 0 Family of unknown function (DUF5347) UCH PF00443.29 EFA82923.1 - 3.4e-05 23.5 1.8 3.4e-05 23.5 1.8 2.4 2 1 1 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Metallothio_PEC PF02068.16 EFA82924.1 - 0.00061 20.1 33.0 0.0044 17.3 33.0 1.9 1 1 0 1 1 1 1 Plant PEC family metallothionein Metallothio_2 PF01439.18 EFA82924.1 - 0.0056 17.5 32.7 0.28 12.1 13.2 2.0 2 0 0 2 2 2 2 Metallothionein Metallothio_Euk PF12749.7 EFA82924.1 - 1.2 9.4 33.6 1.7 8.9 33.6 1.3 1 0 0 1 1 1 0 Eukaryotic metallothionein HA2 PF04408.23 EFA82926.1 - 1.3e-23 83.4 0.0 1.3e-23 83.4 0.0 4.9 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA82926.1 - 2.1e-23 82.5 0.1 5.4e-23 81.2 0.1 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFA82926.1 - 1.3e-12 48.0 0.0 3.9e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA82926.1 - 1.4e-06 28.2 0.0 3.4e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase PWI PF01480.17 EFA82926.1 - 6.6e-06 26.4 0.0 2.3e-05 24.6 0.0 2.0 2 0 0 2 2 1 1 PWI domain AAA_30 PF13604.6 EFA82926.1 - 5.7e-05 22.9 0.0 0.00013 21.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA82926.1 - 9.4e-05 22.7 0.0 0.00035 20.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA82926.1 - 0.00014 22.2 0.0 0.00038 20.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFA82926.1 - 0.0015 17.6 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.14 EFA82926.1 - 0.0035 17.3 0.0 0.0066 16.4 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain SRP54 PF00448.22 EFA82926.1 - 0.014 15.1 0.2 0.072 12.7 0.1 2.3 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain Helicase_RecD PF05127.14 EFA82926.1 - 0.057 13.3 0.4 0.35 10.7 0.0 2.6 3 0 0 3 3 3 0 Helicase Ank_2 PF12796.7 EFA82927.1 - 1.2e-15 57.8 6.1 4.4e-05 24.0 0.1 5.7 1 1 6 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82927.1 - 4.6e-14 52.6 7.3 0.00011 22.6 0.0 8.1 4 1 5 9 9 9 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA82927.1 - 2.3e-11 43.7 2.2 0.025 14.9 0.0 8.1 7 4 3 10 10 10 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82927.1 - 3.1e-09 36.3 7.6 8 7.4 0.0 10.1 12 0 0 12 12 12 2 Ankyrin repeat Peptidase_M48 PF01435.18 EFA82928.1 - 1.1e-35 123.2 0.0 2.3e-35 122.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M48 UPF0444 PF15475.6 EFA82928.1 - 0.36 11.1 0.1 0.36 11.1 0.1 1.7 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Macoilin PF09726.9 EFA82928.1 - 1.4 7.4 14.9 1.8 7.0 14.9 1.1 1 0 0 1 1 1 0 Macoilin family WD40 PF00400.32 EFA82929.1 - 1.4e-09 38.4 13.4 0.084 13.8 0.1 8.0 8 0 0 8 8 8 4 WD domain, G-beta repeat Bap31 PF05529.12 EFA82930.1 - 1.6e-23 83.1 3.8 2.8e-23 82.3 3.8 1.4 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EFA82930.1 - 5.8e-06 26.2 12.6 5.8e-06 26.2 12.6 2.1 1 1 1 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain UPF0242 PF06785.11 EFA82930.1 - 0.0035 17.5 5.3 0.0055 16.8 5.3 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus 7TM_GPCR_Srt PF10321.9 EFA82930.1 - 0.0093 15.0 1.8 0.013 14.5 1.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt YabA PF06156.13 EFA82930.1 - 0.018 15.6 7.2 0.034 14.8 7.2 1.4 1 0 0 1 1 1 0 Initiation control protein YabA WD40_alt PF14077.6 EFA82930.1 - 0.019 14.8 1.9 0.039 13.8 1.9 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Colicin_V PF02674.16 EFA82930.1 - 0.041 13.8 1.6 0.075 13.0 1.6 1.4 1 0 0 1 1 1 0 Colicin V production protein PHR PF08005.12 EFA82930.1 - 0.079 13.6 1.2 0.18 12.5 0.7 1.7 1 1 1 2 2 2 0 PHR domain DUF2935 PF11155.8 EFA82930.1 - 0.14 12.5 2.8 0.21 11.9 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) HALZ PF02183.18 EFA82930.1 - 0.22 11.8 9.0 4.1 7.7 0.2 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper DivIC PF04977.15 EFA82930.1 - 8.5 6.2 9.8 71 3.3 9.9 2.4 1 1 0 1 1 1 0 Septum formation initiator TGT PF01702.18 EFA82931.1 - 3.2e-80 269.9 0.2 5e-80 269.3 0.2 1.2 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase zf-Di19 PF05605.12 EFA82931.1 - 5.1e-19 68.3 1.0 5.1e-19 68.3 1.0 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.17 EFA82931.1 - 0.00039 20.2 2.7 0.00039 20.2 2.7 3.2 4 0 0 4 4 4 1 Zinc finger, ZZ type Di19_C PF14571.6 EFA82931.1 - 0.016 15.7 2.5 0.016 15.7 2.5 3.9 2 1 1 3 3 2 0 Stress-induced protein Di19, C-terminal HTH_10 PF04967.12 EFA82931.1 - 0.03 14.1 0.1 3.2 7.6 0.0 3.1 3 0 0 3 3 3 0 HTH DNA binding domain zf-H2C2_2 PF13465.6 EFA82931.1 - 1.1 9.8 6.9 16 6.2 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zinc_ribbon_10 PF10058.9 EFA82931.1 - 1.4 8.7 5.0 15 5.4 0.1 3.3 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein STAT_bind PF02864.15 EFA82931.1 - 3.2 8.3 11.2 0.63 10.6 5.5 2.7 3 0 0 3 3 2 0 STAT protein, DNA binding domain Menin PF05053.13 EFA82931.1 - 4.5 5.5 14.9 7.6 4.8 14.9 1.3 1 0 0 1 1 1 0 Menin Elf1 PF05129.13 EFA82931.1 - 6.4 6.9 8.9 0.93 9.6 0.4 3.2 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like CDC45 PF02724.14 EFA82931.1 - 9.3 4.4 21.7 1.7 6.8 6.4 2.3 2 0 0 2 2 2 0 CDC45-like protein TIP120 PF08623.10 EFA82933.1 - 8.7e-55 185.0 14.2 4.9e-53 179.3 0.1 5.9 8 0 0 8 8 8 2 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 EFA82933.1 - 3.3e-14 53.0 0.1 0.056 14.0 0.0 9.0 9 0 0 9 9 8 2 HEAT-like repeat HEAT PF02985.22 EFA82933.1 - 6.6e-13 47.7 10.7 2.3 8.7 0.1 11.3 12 0 0 12 12 12 3 HEAT repeat HEAT_2 PF13646.6 EFA82933.1 - 5e-11 42.8 6.2 0.025 15.0 0.0 6.8 7 0 0 7 7 7 3 HEAT repeats Cnd1 PF12717.7 EFA82933.1 - 1.5e-09 38.1 35.5 0.0088 16.1 0.0 9.0 4 2 1 7 7 7 3 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EFA82933.1 - 2.1e-05 24.5 5.2 0.13 12.2 0.0 6.2 5 3 0 6 6 6 1 Domain of unknown function (DUF3385) ParcG PF10274.9 EFA82933.1 - 0.00056 20.1 16.5 0.022 14.9 0.1 7.2 5 3 0 6 6 6 1 Parkin co-regulated protein TAF6_C PF07571.13 EFA82933.1 - 0.0022 18.3 0.6 0.13 12.6 0.1 3.8 3 1 0 3 3 2 1 TAF6 C-terminal HEAT repeat domain UME PF08064.13 EFA82933.1 - 0.0023 17.8 8.7 37 4.3 0.0 7.5 8 1 0 8 8 7 0 UME (NUC010) domain DUF4924 PF16271.5 EFA82933.1 - 0.023 14.7 0.1 0.16 12.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4924) RRN3 PF05327.11 EFA82933.1 - 0.042 12.4 3.1 0.14 10.6 3.1 1.9 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Condensin2nSMC PF12422.8 EFA82933.1 - 0.06 13.5 1.0 6.5 6.9 0.0 4.1 3 1 1 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit RTP1_C1 PF10363.9 EFA82933.1 - 0.1 12.7 14.1 0.58 10.4 0.3 6.5 6 2 2 8 8 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Telomere_reg-2 PF10193.9 EFA82933.1 - 0.22 12.0 10.1 0.54 10.7 0.5 5.1 5 0 0 5 5 4 0 Telomere length regulation protein TFIIA PF03153.13 EFA82933.1 - 0.85 9.6 4.7 1.8 8.5 4.7 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arm PF00514.23 EFA82933.1 - 1.9 8.7 10.3 29 4.9 0.1 6.1 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Astro_capsid_p PF12226.8 EFA82933.1 - 1.9 7.5 9.2 3.5 6.7 9.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein V-ATPase_H_C PF11698.8 EFA82933.1 - 4.3 7.5 16.0 5.8 7.0 0.2 6.8 7 2 3 10 10 10 0 V-ATPase subunit H tRNA-synt_His PF13393.6 EFA82934.1 - 6.8e-47 160.2 0.0 9.4e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EFA82934.1 - 3.5e-11 43.1 0.0 8.5e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EFA82934.1 - 0.0011 18.2 0.0 0.0089 15.1 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) HGTP_anticodon2 PF12745.7 EFA82934.1 - 0.0029 17.2 0.1 0.006 16.1 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2b PF00587.25 EFA82934.1 - 0.0052 16.8 0.0 0.028 14.4 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SET PF00856.28 EFA82935.1 - 3e-10 40.7 5.8 6.7e-10 39.6 5.8 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 EFA82935.1 - 0.0034 17.4 10.4 0.0034 17.4 10.4 2.3 3 0 0 3 3 3 1 MYND finger DUF2256 PF10013.9 EFA82935.1 - 2.8 8.1 9.7 2.2 8.5 4.8 2.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zinc_ribbon_12 PF11331.8 EFA82935.1 - 3.3 7.6 10.2 0.32 10.8 3.4 2.5 2 0 0 2 2 2 0 Probable zinc-ribbon domain CEBP_ZZ PF16366.5 EFA82935.1 - 8.5 6.7 19.9 1.8 8.9 6.2 3.2 2 1 1 3 3 3 0 Cytoplasmic polyadenylation element-binding protein ZZ domain ChaC PF04752.12 EFA82936.1 - 2.1e-51 174.5 0.0 8.9e-51 172.5 0.0 1.9 2 0 0 2 2 2 1 ChaC-like protein Sulfotransfer_1 PF00685.27 EFA82936.1 - 7e-18 65.1 1.0 3e-17 63.0 1.0 1.9 1 1 0 1 1 1 1 Sulfotransferase domain PUA PF01472.20 EFA82936.1 - 2.4e-16 59.4 0.1 4.1e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 PUA domain Sulfotransfer_3 PF13469.6 EFA82936.1 - 1.5e-14 54.9 0.4 0.00027 21.4 0.0 3.6 2 1 1 3 3 3 3 Sulfotransferase family DUF3024 PF11225.8 EFA82936.1 - 0.048 13.9 1.2 8.2 6.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) Myb_CC_LHEQLE PF14379.6 EFA82936.1 - 0.081 12.7 1.1 0.19 11.5 1.1 1.5 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif Proteasome PF00227.26 EFA82937.1 - 8.8e-46 155.8 0.5 1.1e-45 155.5 0.5 1.1 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_S5 PF00333.20 EFA82938.1 - 5e-29 100.1 2.8 8.7e-29 99.3 2.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFA82938.1 - 1.6e-24 85.1 0.1 2.9e-24 84.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EFA82938.1 - 9.3 6.9 16.0 21 5.7 16.0 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Colicin PF01024.19 EFA82941.1 - 0.59 10.0 3.2 1.2 9.0 3.2 1.5 1 0 0 1 1 1 0 Colicin pore forming domain Cpn60_TCP1 PF00118.24 EFA82942.1 - 1.2e-91 307.8 6.0 1.2e-90 304.5 6.0 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PAP_RNA-bind PF04926.15 EFA82942.1 - 0.31 10.7 2.7 0.67 9.6 2.7 1.5 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain Phage_holin_3_6 PF07332.11 EFA82944.1 - 1.7 8.7 14.1 0.33 11.0 9.7 1.9 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III BacteriocIIc_cy PF12173.8 EFA82944.1 - 4.5 7.6 11.1 8 6.8 11.1 1.4 1 0 0 1 1 1 0 Bacteriocin class IIc cyclic gassericin A-like Pkinase PF00069.25 EFA82945.1 - 1.4e-74 250.8 0.0 1.9e-74 250.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82945.1 - 3.9e-32 111.5 0.0 5.2e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EFA82945.1 - 5.2e-15 55.5 0.7 1e-14 54.6 0.1 1.9 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.6 EFA82945.1 - 3.7e-13 49.4 0.0 8.3e-13 48.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Yop-YscD_cpl PF16697.5 EFA82945.1 - 4.8e-07 30.0 0.0 1.4e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Haspin_kinase PF12330.8 EFA82945.1 - 6.4e-05 22.1 0.8 0.00017 20.6 0.2 1.9 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFA82945.1 - 0.00026 21.0 0.1 0.0019 18.2 0.1 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA82945.1 - 0.0022 17.4 0.1 0.0035 16.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FHA_2 PF17913.1 EFA82945.1 - 0.011 16.0 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 FHA domain YukC PF10140.9 EFA82945.1 - 0.039 12.8 0.1 0.06 12.2 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Pkinase PF00069.25 EFA82946.1 - 2.7e-55 187.6 0.1 6.2e-55 186.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA82946.1 - 4.3e-21 75.4 0.0 1e-20 74.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFA82946.1 - 0.004 17.1 0.0 0.0061 16.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA82946.1 - 0.049 13.0 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LCM PF04072.14 EFA82947.1 - 2.7e-29 102.4 0.0 5.9e-29 101.3 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase MA3 PF02847.17 EFA82948.1 - 2.3e-28 98.5 2.1 4e-28 97.7 1.4 1.8 2 0 0 2 2 2 1 MA3 domain ATP-grasp_2 PF08442.10 EFA82949.1 - 8.3e-77 257.3 0.8 1.2e-76 256.7 0.2 1.6 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EFA82949.1 - 1.1e-25 90.3 2.1 1.7e-25 89.6 2.1 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EFA82949.1 - 4.2e-09 36.2 0.0 8.7e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFA82949.1 - 7.6e-05 22.6 0.8 0.0012 18.6 0.0 2.6 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Succ_CoA_lig PF13607.6 EFA82949.1 - 0.026 14.3 0.4 0.97 9.2 0.2 2.3 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain DUF4288 PF14119.6 EFA82949.1 - 0.069 13.6 0.1 1.3 9.5 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4288) RasGEF PF00617.19 EFA82950.1 - 1e-50 172.4 1.8 1e-50 172.4 1.8 2.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFA82950.1 - 3.8e-15 56.0 3.4 3.8e-15 56.0 3.4 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif AATF-Che1 PF13339.6 EFA82950.1 - 1.5 9.5 6.5 14 6.4 0.2 3.0 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor Peptidase_C1 PF00112.23 EFA82951.1 - 1.5e-58 198.5 8.7 1.5e-58 198.5 8.7 2.2 2 0 0 2 2 2 1 Papain family cysteine protease Ank_2 PF12796.7 EFA82951.1 - 1.6e-28 99.1 20.9 5.2e-07 30.2 0.1 10.0 4 3 6 10 10 10 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82951.1 - 1.6e-26 92.3 22.8 4.9e-05 23.8 0.3 14.1 12 4 3 15 15 15 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA82951.1 - 3.6e-19 68.6 11.7 0.025 14.9 0.0 14.0 8 4 10 18 18 18 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82951.1 - 1.5e-10 40.4 14.3 3.4 8.5 0.0 13.5 18 0 0 18 18 18 3 Ankyrin repeat DUF3447 PF11929.8 EFA82951.1 - 0.0012 18.7 32.8 0.22 11.5 1.2 8.4 5 2 4 10 10 10 4 Domain of unknown function (DUF3447) DUF1843 PF08898.10 EFA82951.1 - 0.0028 18.1 0.0 71 4.0 0.0 5.3 6 0 0 6 6 6 0 Domain of unknown function (DUF1843) Ank PF00023.30 EFA82951.1 - 0.0045 17.4 0.3 50 4.6 0.0 6.2 7 0 0 7 7 7 0 Ankyrin repeat Plasmod_dom_1 PF09715.10 EFA82951.1 - 2.8 8.1 7.5 5.9 7.0 0.1 5.2 4 1 0 4 4 4 0 Plasmodium protein of unknown function (Plasmod_dom_1) Thioredoxin PF00085.20 EFA82952.1 - 3.6e-16 59.0 0.0 4.2e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFA82952.1 - 0.0018 18.7 0.1 0.013 15.9 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EFA82952.1 - 0.0079 16.1 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFA82952.1 - 0.054 13.2 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.6 EFA82952.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like GDP_Man_Dehyd PF16363.5 EFA82953.1 - 1.2e-28 100.6 0.0 1.3e-28 100.3 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA82953.1 - 3.2e-28 98.8 0.0 3.9e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA82953.1 - 1.2e-14 54.0 0.0 1.8e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFA82953.1 - 3.9e-11 42.6 0.0 6.8e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFA82953.1 - 7.1e-07 28.6 0.0 1.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EFA82953.1 - 0.00028 21.1 0.1 0.00069 19.9 0.1 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 EFA82953.1 - 0.00051 19.3 0.0 0.68 9.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EFA82953.1 - 0.0033 16.9 0.0 0.0051 16.3 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFA82953.1 - 0.0053 16.7 0.1 0.011 15.6 0.1 1.6 1 1 0 1 1 1 1 KR domain DUF1188 PF06690.11 EFA82953.1 - 0.074 12.6 0.2 0.1 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) Pet100 PF09803.9 EFA82954.1 - 1.9e-08 34.7 0.2 1.9e-08 34.7 0.2 2.4 1 1 1 2 2 2 1 Pet100 Vir_act_alpha_C PF10400.9 EFA82954.1 - 0.067 13.9 4.6 0.12 13.1 4.6 1.4 1 0 0 1 1 1 0 Virulence activator alpha C-term DUF1828 PF08861.10 EFA82954.1 - 0.069 13.4 2.4 0.11 12.8 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF1828 Pex26 PF07163.12 EFA82954.1 - 3.4 6.9 7.8 4.4 6.5 7.8 1.3 1 1 0 1 1 1 0 Pex26 protein DHFR_1 PF00186.19 EFA82955.1 - 1.2e-39 135.6 0.0 1.8e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 Dihydrofolate reductase Intein_splicing PF14890.6 EFA82955.1 - 0.0067 16.4 0.1 0.0079 16.1 0.1 1.2 1 0 0 1 1 1 1 Intein splicing domain Patatin PF01734.22 EFA82956.1 - 3.1e-12 47.1 0.2 2.4e-11 44.2 0.2 2.5 1 1 0 1 1 1 1 Patatin-like phospholipase PH PF00169.29 EFA82956.1 - 2.6e-09 37.5 4.7 5.8e-09 36.4 4.7 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA82956.1 - 0.0082 16.5 8.2 0.023 15.1 8.2 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain FERM_C PF09380.10 EFA82956.1 - 0.047 14.1 1.5 0.14 12.6 1.5 1.7 1 0 0 1 1 1 0 FERM C-terminal PH-like domain Cullin PF00888.22 EFA82957.1 - 2.3e-160 535.2 37.0 1.1e-131 440.5 19.1 2.8 2 1 1 3 3 3 2 Cullin family Cullin_Nedd8 PF10557.9 EFA82957.1 - 8.5e-11 41.7 0.7 8.5e-11 41.7 0.7 4.0 4 0 0 4 4 4 1 Cullin protein neddylation domain Ank_2 PF12796.7 EFA82957.1 - 0.00021 21.8 0.0 0.00071 20.1 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Calici_coat_C PF08435.11 EFA82957.1 - 0.66 9.4 4.1 4.2 6.8 0.0 2.5 2 0 0 2 2 2 0 Calicivirus coat protein C-terminal Ank_2 PF12796.7 EFA82958.1 - 1.1e-17 64.4 8.1 1.8e-06 28.4 0.1 3.7 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA82958.1 - 6.1e-15 55.4 4.2 0.0066 17.0 0.1 6.0 2 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA82958.1 - 1e-13 50.1 0.4 0.53 11.0 0.0 6.9 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EFA82958.1 - 6.4e-13 48.7 3.2 0.093 13.1 0.1 7.8 3 2 6 9 9 9 5 Ankyrin repeats (many copies) Ank PF00023.30 EFA82958.1 - 0.012 16.0 1.6 43 4.8 0.2 4.9 3 1 1 4 4 4 0 Ankyrin repeat Shigella_OspC PF06128.11 EFA82958.1 - 0.035 13.8 3.7 1.2 8.9 0.2 2.7 1 1 0 2 2 2 0 Shigella flexneri OspC protein RNB PF00773.19 EFA82959.1 - 3.8e-96 322.3 0.0 6.6e-96 321.5 0.0 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EFA82959.1 - 6.7e-18 64.5 0.0 1.5e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 EFA82959.1 - 1.4e-14 54.0 0.0 3.5e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain PIN_4 PF13638.6 EFA82959.1 - 5.9e-14 52.5 2.3 1.6e-13 51.1 2.3 1.8 1 0 0 1 1 1 1 PIN domain Rrp44_S1 PF17215.3 EFA82959.1 - 7.4e-11 41.9 0.1 1.7e-10 40.7 0.1 1.6 1 0 0 1 1 1 1 S1 domain CSD2 PF17876.1 EFA82959.1 - 2.8e-10 40.2 0.0 4.3e-05 23.6 0.0 3.0 2 0 0 2 2 2 2 Cold shock domain Dis3l2_C_term PF17877.1 EFA82959.1 - 0.0076 16.6 0.0 0.023 15.0 0.0 1.9 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Glyco_hydro_18 PF00704.28 EFA82960.1 - 1.4e-52 179.4 3.6 2.6e-52 178.5 3.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFA82960.1 - 1.1e-08 35.0 0.0 0.0026 17.8 0.0 3.3 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.19 EFA82960.1 - 2.3e-08 34.4 9.4 2.3e-08 34.4 9.4 4.2 4 0 0 4 4 4 1 Chitin recognition protein DUF4298 PF14131.6 EFA82961.1 - 0.044 13.8 0.2 0.14 12.1 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4298) SNF2_N PF00176.23 EFA82962.1 - 5.7e-29 100.9 0.1 1.1e-28 99.9 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 EFA82962.1 - 8.1e-05 22.5 0.0 0.00022 21.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA82963.1 - 2.6e-19 69.6 0.1 1e-18 67.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFA82963.1 - 6.8e-07 28.3 11.2 1.9e-06 26.9 9.3 2.4 2 1 0 2 2 2 1 SNF2 family N-terminal domain HDA2-3 PF11496.8 EFA82963.1 - 0.00088 18.5 9.4 0.3 10.2 1.2 3.4 2 2 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 Myc_N PF01056.18 EFA82963.1 - 0.024 14.6 4.3 0.035 14.0 4.3 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF913 PF06025.12 EFA82963.1 - 0.35 9.8 5.1 0.63 9.0 5.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PGA2 PF07543.12 EFA82963.1 - 0.64 10.0 13.2 1.4 8.9 13.2 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Indigoidine_A PF04227.12 EFA82965.1 - 2.2e-120 401.4 0.6 4.2e-120 400.5 0.6 1.5 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EFA82965.1 - 2e-31 109.5 0.1 7.5e-31 107.5 0.1 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase SNAP PF14938.6 EFA82966.1 - 4e-09 36.3 2.5 3.2e-08 33.4 2.3 2.1 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFA82966.1 - 1.1e-05 25.6 1.6 0.024 14.9 0.1 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA82966.1 - 1.4e-05 24.8 4.4 0.0008 19.3 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA82966.1 - 0.0025 17.6 0.1 0.0025 17.6 0.1 3.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA82966.1 - 0.0027 17.8 0.3 0.0027 17.8 0.3 3.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA82966.1 - 0.0059 16.5 0.2 0.33 11.1 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA82966.1 - 0.06 13.6 2.0 0.34 11.2 0.1 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SRP_TPR_like PF17004.5 EFA82966.1 - 0.082 12.9 1.4 1.5 8.8 0.6 2.7 2 1 0 2 2 2 0 Putative TPR-like repeat TPR_16 PF13432.6 EFA82966.1 - 0.11 13.1 0.0 2.3 8.9 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Clat_adaptor_s PF01217.20 EFA82967.1 - 2.1e-26 92.5 5.5 4.3e-17 62.4 2.8 2.0 1 1 1 2 2 2 2 Clathrin adaptor complex small chain MRG PF05712.13 EFA82967.1 - 0.083 12.2 0.2 0.1 11.9 0.2 1.1 1 0 0 1 1 1 0 MRG FMO-like PF00743.19 EFA82968.1 - 4.1e-63 213.6 0.0 4.6e-42 144.1 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFA82968.1 - 1.9e-26 93.1 0.0 2.5e-23 82.8 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA82968.1 - 5.5e-12 45.5 0.0 7.6e-11 41.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFA82968.1 - 3.1e-11 43.0 0.5 1.2e-10 41.1 0.0 2.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFA82968.1 - 4.2e-07 29.9 0.0 0.0019 17.8 0.1 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFA82968.1 - 1.1e-06 28.7 0.0 0.00029 20.9 0.1 3.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFA82968.1 - 0.00019 21.6 0.0 0.00042 20.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFA82968.1 - 0.00021 20.2 0.0 0.0012 17.6 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EFA82968.1 - 0.0035 16.8 0.0 0.0055 16.1 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFA82968.1 - 0.034 13.2 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EFA82968.1 - 0.11 11.5 0.4 0.91 8.5 0.4 2.0 1 1 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EFA82968.1 - 0.17 11.1 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Y_phosphatase PF00102.27 EFA82970.1 - 1.7e-68 230.7 4.4 3.5e-67 226.4 4.4 2.3 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFA82970.1 - 1.4e-05 24.9 0.2 1.4e-05 24.9 0.2 2.8 2 2 2 4 4 4 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFA82970.1 - 1.5e-05 25.2 0.3 0.00019 21.6 0.0 2.6 1 1 1 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFA82970.1 - 0.0013 18.7 0.0 0.0025 17.8 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Yeast-kill-tox PF09207.11 EFA82970.1 - 1.3 9.7 4.3 6.5 7.5 0.1 2.6 3 0 0 3 3 3 0 Yeast killer toxin AAA_25 PF13481.6 EFA82972.1 - 8.1e-22 77.7 0.0 1.4e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EFA82972.1 - 4.6e-09 36.0 0.2 2e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Toprim_2 PF13155.6 EFA82972.1 - 1.8e-07 31.5 0.0 7.4e-07 29.5 0.0 2.1 1 0 0 1 1 1 1 Toprim-like AAA_22 PF13401.6 EFA82972.1 - 2.1e-06 28.1 0.2 8.8e-06 26.0 0.2 2.0 1 1 0 1 1 1 1 AAA domain Toprim_4 PF13662.6 EFA82972.1 - 7.7e-06 26.3 0.0 0.0001 22.7 0.0 2.5 2 0 0 2 2 2 1 Toprim domain ATPase PF06745.13 EFA82972.1 - 0.00049 19.5 0.1 0.00088 18.7 0.1 1.3 1 0 0 1 1 1 1 KaiC AAA_16 PF13191.6 EFA82972.1 - 0.00055 20.3 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFA82972.1 - 0.0033 17.4 0.4 0.015 15.2 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EFA82972.1 - 0.012 15.3 1.2 0.2 11.4 0.1 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 EFA82972.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2188 PF09954.9 EFA82972.1 - 0.012 15.7 0.0 0.033 14.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) AAA PF00004.29 EFA82972.1 - 0.022 15.2 0.4 0.21 12.0 0.0 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFA82972.1 - 0.042 14.4 0.0 0.042 14.4 0.0 2.3 2 1 0 2 2 1 0 ABC transporter IstB_IS21 PF01695.17 EFA82972.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.22 EFA82972.1 - 0.1 11.8 0.0 0.25 10.5 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 EFA82972.1 - 0.12 12.3 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 EFA82972.1 - 0.17 12.2 0.3 0.34 11.1 0.3 1.7 1 1 0 1 1 1 0 AAA domain Ank_2 PF12796.7 EFA82973.1 - 0.00036 21.1 0.1 0.0012 19.4 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA82973.1 - 0.022 15.2 0.0 0.82 10.4 0.0 3.2 2 0 0 2 2 2 0 Ankyrin repeat RMI1_N PF08585.12 EFA82974.1 - 0.2 11.4 4.1 0.37 10.5 4.1 1.4 1 0 0 1 1 1 0 RecQ mediated genome instability protein ALMT PF11744.8 EFA82974.1 - 0.46 9.2 10.2 0.68 8.7 10.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DASH_Spc19 PF08287.11 EFA82974.1 - 2.3 8.1 9.6 4.1 7.3 9.6 1.3 1 0 0 1 1 1 0 Spc19 Cmc1 PF08583.10 EFA82975.1 - 0.091 12.8 8.1 0.62 10.1 4.3 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CLPTM1 PF05602.12 EFA82976.1 - 5.8e-129 430.9 13.4 7.5e-129 430.5 13.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EFA82976.1 - 0.00019 21.1 2.5 0.4 10.5 0.3 3.2 2 1 0 2 2 2 2 PQ loop repeat SelP_N PF04592.14 EFA82976.1 - 0.22 10.9 14.7 0.4 10.0 14.7 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MtN3_slv PF03083.16 EFA82976.1 - 1 9.4 10.4 0.17 12.0 1.7 3.3 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange PDZ_3 PF17815.1 EFA82977.1 - 2.5e-40 137.7 0.1 4.4e-40 136.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 EFA82977.1 - 4.3e-22 79.6 0.1 7.2e-22 78.9 0.1 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA82977.1 - 8.2e-15 55.2 0.0 1.7e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 EFA82977.1 - 8e-10 38.9 0.0 1.1e-07 32.1 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EFA82977.1 - 1.6e-06 27.9 0.4 0.015 15.1 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 EFA82977.1 - 6.3e-06 26.5 0.4 0.0017 18.7 0.0 2.6 2 0 0 2 2 2 1 PDZ domain Haem_bd PF14376.6 EFA82977.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Haem-binding domain CW_binding_1 PF01473.20 EFA82977.1 - 0.31 11.5 0.7 0.98 9.9 0.7 1.8 1 0 0 1 1 1 0 Putative cell wall binding repeat HSF_DNA-bind PF00447.17 EFA82978.1 - 3.4e-26 91.7 1.6 3.4e-26 91.7 1.6 4.0 4 1 0 4 4 4 1 HSF-type DNA-binding ZapB PF06005.12 EFA82978.1 - 0.0026 18.2 0.6 0.0026 18.2 0.6 6.3 4 1 2 6 6 6 1 Cell division protein ZapB Histone PF00125.24 EFA82979.1 - 7.2e-48 162.3 1.7 8.6e-48 162.0 1.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFA82979.1 - 0.00074 19.6 0.2 0.0015 18.7 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFA82979.1 - 0.0015 18.8 0.0 0.0025 18.2 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBS PF00571.28 EFA82980.1 - 1.3e-29 102.4 5.8 2.1e-10 40.9 0.2 4.2 4 0 0 4 4 4 4 CBS domain ATP-synt_C PF00137.21 EFA82981.1 - 7.1e-29 99.9 36.3 2e-18 66.5 15.8 2.2 2 0 0 2 2 2 2 ATP synthase subunit C ATP-synt_C PF00137.21 EFA82982.1 - 4.6e-29 100.5 30.1 1.6e-14 54.0 10.4 2.3 2 0 0 2 2 2 2 ATP synthase subunit C SLATT_5 PF18160.1 EFA82982.1 - 0.053 12.8 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Oxidored_q2 PF00420.24 EFA82982.1 - 0.11 12.1 0.1 0.11 12.1 0.1 2.4 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L AAA PF00004.29 EFA82983.1 - 3e-59 199.2 0.0 1.4e-42 145.3 0.0 3.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EFA82983.1 - 1.9e-25 89.1 4.4 6.5e-25 87.4 4.4 2.0 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.6 EFA82983.1 - 2.8e-12 47.4 0.2 3e-05 24.5 0.0 3.6 2 1 1 3 3 3 2 AAA ATPase domain Mg_chelatase PF01078.21 EFA82983.1 - 9.9e-09 34.9 0.6 0.012 14.9 0.1 3.5 4 0 0 4 4 3 2 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EFA82983.1 - 1.4e-08 34.8 0.0 0.0015 18.5 0.0 3.2 3 0 0 3 3 3 2 NACHT domain IstB_IS21 PF01695.17 EFA82983.1 - 2.1e-07 30.9 0.0 0.016 15.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_5 PF07728.14 EFA82983.1 - 2.1e-07 31.0 0.3 0.0086 16.1 0.0 3.3 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFA82983.1 - 2.4e-07 31.1 0.2 0.071 13.4 0.0 3.8 3 1 1 4 4 3 2 AAA domain AAA_2 PF07724.14 EFA82983.1 - 4.8e-07 30.0 0.0 0.037 14.1 0.0 3.3 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) PEX-2N PF09263.10 EFA82983.1 - 5.8e-07 29.7 0.0 5.2e-06 26.7 0.0 2.6 2 1 0 2 2 2 1 Peroxisome biogenesis factor 1, N-terminal AAA_14 PF13173.6 EFA82983.1 - 6.4e-07 29.5 0.1 0.044 13.8 0.0 3.7 3 0 0 3 3 3 2 AAA domain TIP49 PF06068.13 EFA82983.1 - 2.3e-06 27.1 0.5 0.073 12.3 0.1 2.9 3 0 0 3 3 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 EFA82983.1 - 2.8e-06 27.7 0.0 0.048 14.1 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_lid_3 PF17862.1 EFA82983.1 - 3e-06 26.9 0.1 8.6e-06 25.5 0.0 1.8 2 0 0 2 2 1 1 AAA+ lid domain RuvB_N PF05496.12 EFA82983.1 - 6.3e-06 26.0 0.0 0.00053 19.8 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EFA82983.1 - 9.9e-06 25.3 0.1 0.08 12.5 0.0 2.8 3 0 0 3 3 3 2 AAA domain CDC48_2 PF02933.17 EFA82983.1 - 4.2e-05 23.2 0.1 0.0001 22.0 0.1 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 ATPase_2 PF01637.18 EFA82983.1 - 8.3e-05 22.6 1.4 0.15 11.9 0.0 3.2 3 0 0 3 3 2 2 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 EFA82983.1 - 0.00029 20.6 0.0 0.065 12.9 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 EFA82983.1 - 0.00035 20.8 0.6 0.22 11.7 0.0 3.1 3 0 0 3 3 2 1 AAA domain T2SSE PF00437.20 EFA82983.1 - 0.00037 19.7 0.1 0.038 13.0 0.1 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_28 PF13521.6 EFA82983.1 - 0.00053 20.3 2.0 0.41 10.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EFA82983.1 - 0.00063 20.3 16.3 0.00064 20.3 0.0 5.0 5 2 0 5 5 4 2 AAA domain Rad17 PF03215.15 EFA82983.1 - 0.00084 19.3 3.0 0.01 15.7 0.0 3.4 3 0 0 3 3 2 1 Rad17 P-loop domain CDC48_N PF02359.18 EFA82983.1 - 0.0014 18.8 0.1 4.2 7.6 0.0 3.0 2 0 0 2 2 2 2 Cell division protein 48 (CDC48), N-terminal domain TsaE PF02367.17 EFA82983.1 - 0.0014 18.6 0.1 0.32 11.0 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EFA82983.1 - 0.0021 18.5 2.8 0.15 12.4 0.0 3.8 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EFA82983.1 - 0.0067 15.9 0.2 1.9 7.9 0.1 2.6 2 0 0 2 2 2 1 PhoH-like protein NB-ARC PF00931.22 EFA82983.1 - 0.0091 15.2 0.0 1.7 7.7 0.0 2.9 2 0 0 2 2 2 1 NB-ARC domain AAA_29 PF13555.6 EFA82983.1 - 0.0096 15.7 0.4 0.96 9.2 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFA82983.1 - 0.012 14.9 0.0 4.2 6.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.6 EFA82983.1 - 0.013 15.2 4.1 0.53 10.0 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EFA82983.1 - 0.02 14.4 4.1 3.4 7.1 0.0 3.2 3 0 0 3 3 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EFA82983.1 - 0.039 13.9 0.1 2.8 7.8 0.0 2.8 2 0 0 2 2 2 0 NTPase Molydop_binding PF01568.21 EFA82983.1 - 0.041 13.9 0.0 0.36 10.9 0.1 2.6 2 1 1 3 3 2 0 Molydopterin dinucleotide binding domain ABC_tran PF00005.27 EFA82983.1 - 0.064 13.8 14.2 0.64 10.5 0.0 4.8 5 0 0 5 5 4 0 ABC transporter ATPase PF06745.13 EFA82983.1 - 0.07 12.5 2.1 7.8 5.8 0.0 3.2 3 0 0 3 3 3 0 KaiC AAA_3 PF07726.11 EFA82983.1 - 0.12 12.2 0.0 4.5 7.1 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FNIP PF05725.12 EFA82984.1 - 1.6e-25 89.0 24.9 1.1e-07 31.9 0.8 8.4 4 2 5 9 9 9 8 FNIP Repeat LRR_6 PF13516.6 EFA82984.1 - 0.03 14.4 2.4 0.86 9.8 0.0 3.4 4 0 0 4 4 4 0 Leucine Rich repeat F-box-like PF12937.7 EFA82984.1 - 0.035 14.0 0.7 0.081 12.8 0.7 1.6 1 0 0 1 1 1 0 F-box-like LRR_1 PF00560.33 EFA82984.1 - 1 10.2 5.3 37 5.4 0.1 4.8 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 EFA82984.1 - 1.7 9.2 15.2 3.4 8.2 0.2 5.0 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) DIM1 PF02966.16 EFA82985.1 - 0.032 14.0 0.3 0.032 14.0 0.3 1.0 1 0 0 1 1 1 0 Mitosis protein DIM1 DUF1769 PF08588.10 EFA82985.1 - 0.18 12.0 0.0 0.27 11.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1769) Response_reg PF00072.24 EFA82986.1 - 2.5e-31 108.1 1.1 5.9e-22 77.9 0.0 2.7 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 EFA82986.1 - 7.5e-30 103.7 0.0 4.2e-29 101.3 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFA82986.1 - 8.6e-13 48.1 0.3 2.7e-12 46.6 0.3 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 EFA82986.1 - 0.0096 15.9 0.0 0.55 10.2 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain Costars PF14705.6 EFA82987.1 - 1.9e-27 95.2 0.4 2.1e-27 95.1 0.4 1.0 1 0 0 1 1 1 1 Costars Citrate_bind PF16114.5 EFA82987.1 - 0.08 12.4 0.1 0.088 12.3 0.1 1.0 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding Histone PF00125.24 EFA82988.1 - 2.3e-32 112.1 2.8 3e-31 108.5 2.8 2.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 FNIP PF05725.12 EFA82988.1 - 1.3e-11 44.5 1.8 2.7e-07 30.7 0.0 3.8 1 1 2 3 3 3 3 FNIP Repeat CENP-S PF15630.6 EFA82988.1 - 0.0081 16.5 0.1 0.017 15.5 0.1 1.5 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EFA82988.1 - 0.023 14.8 0.0 0.069 13.3 0.0 1.9 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Myb_DNA-binding PF00249.31 EFA82989.1 - 1.5e-20 73.1 1.9 1.2e-09 38.2 0.4 3.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain DnaJ PF00226.31 EFA82989.1 - 1.9e-18 66.3 1.1 6.1e-18 64.7 0.0 2.6 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.6 EFA82989.1 - 8.1e-08 32.4 5.4 0.0006 20.0 0.2 3.6 4 0 0 4 4 4 2 Myb-like DNA-binding domain DUF1115 PF06544.12 EFA82990.1 - 0.003 17.7 1.9 0.0037 17.4 1.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) Serinc PF03348.15 EFA82990.1 - 0.068 12.1 3.7 0.079 11.9 3.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM176 PF14851.6 EFA82990.1 - 0.26 10.9 4.3 0.33 10.6 4.3 1.1 1 0 0 1 1 1 0 FAM176 family DUF4834 PF16118.5 EFA82990.1 - 0.42 11.6 8.7 0.77 10.8 8.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) HCO3_cotransp PF00955.21 EFA82990.1 - 1.1 8.0 4.6 1.2 7.9 4.6 1.0 1 0 0 1 1 1 0 HCO3- transporter family Presenilin PF01080.17 EFA82990.1 - 6.7 5.4 11.8 8 5.1 11.8 1.1 1 0 0 1 1 1 0 Presenilin Cyclin_N PF00134.23 EFA82991.1 - 3.9e-15 55.7 2.9 3.9e-15 55.7 2.9 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFA82991.1 - 0.0044 17.1 0.1 1.7 8.8 0.0 2.7 2 1 0 2 2 2 2 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 EFA82991.1 - 0.0065 16.8 0.1 0.064 13.7 0.0 2.5 2 1 1 3 3 3 1 Cyclin C-terminal domain Big_3_2 PF12245.8 EFA82992.1 - 0.0046 17.2 0.1 0.0087 16.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial Ig-like domain PapG_C PF03628.13 EFA82992.1 - 0.13 12.1 0.1 0.35 10.8 0.1 1.7 1 0 0 1 1 1 0 PapG chaperone-binding domain Pro-kuma_activ PF09286.11 EFA82993.1 - 2.4e-31 108.9 0.1 3.7e-31 108.3 0.1 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFA82993.1 - 2e-06 27.3 1.2 3.3e-06 26.6 1.2 1.4 1 0 0 1 1 1 1 Subtilase family FNIP PF05725.12 EFA82994.1 - 3.2e-47 158.4 43.1 1.1e-09 38.3 0.8 12.2 4 3 9 14 14 14 13 FNIP Repeat RR_TM4-6 PF06459.12 EFA82995.1 - 0.086 12.7 13.1 0.13 12.0 13.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XRN_M PF17846.1 EFA82995.1 - 0.11 11.4 7.6 0.15 11.0 7.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Hydin_ADK PF17213.3 EFA82995.1 - 0.3 11.3 5.3 0.37 11.0 5.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain TraV PF09676.10 EFA82995.1 - 0.5 11.4 8.7 0.65 11.0 8.7 1.3 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) PA26 PF04636.13 EFA82995.1 - 0.58 9.0 6.8 0.7 8.8 6.8 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CCSAP PF15748.5 EFA82995.1 - 0.59 10.3 19.7 0.71 10.0 19.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Efg1 PF10153.9 EFA82995.1 - 0.7 10.3 18.3 0.081 13.3 14.1 1.6 2 0 0 2 2 2 0 rRNA-processing protein Efg1 ALMT PF11744.8 EFA82995.1 - 1.2 7.9 5.2 1.4 7.7 5.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 EFA82995.1 - 1.3 7.8 12.7 1.5 7.5 12.7 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 EFA82995.1 - 1.3 7.1 8.4 1.3 7.0 8.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Atg14 PF10186.9 EFA82995.1 - 2.1 7.4 12.5 2.8 7.0 12.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CDC45 PF02724.14 EFA82995.1 - 3.4 5.9 15.9 3.6 5.7 15.9 1.1 1 0 0 1 1 1 0 CDC45-like protein FancD2 PF14631.6 EFA82995.1 - 4.6 4.5 11.5 6.4 4.0 11.5 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Calcipressin PF04847.12 EFA82996.1 - 4.6e-08 33.0 0.9 6.3e-08 32.6 0.5 1.5 1 1 0 1 1 1 1 Calcipressin Pex14_N PF04695.13 EFA82997.1 - 0.011 16.3 0.3 0.012 16.3 0.3 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3285 PF11688.8 EFA82997.1 - 1.2 9.1 4.0 2.8 7.9 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) IQ PF00612.27 EFA82998.1 - 4.7e-08 32.1 5.6 0.0033 17.1 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif EGF_2 PF07974.13 EFA82998.1 - 0.0021 18.4 13.4 0.0039 17.5 13.4 1.5 1 0 0 1 1 1 1 EGF-like domain DUF3844 PF12955.7 EFA82998.1 - 1.1 9.4 5.8 2.8 8.1 1.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) DUF2616 PF11077.8 EFA82999.1 - 0.097 12.4 9.4 0.19 11.4 8.3 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2616) Peptidase_C1 PF00112.23 EFA83000.1 - 5.6e-73 245.6 6.9 7.8e-61 205.9 1.0 2.3 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFA83000.1 - 6.3e-06 25.2 0.1 0.0043 15.9 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 EFA83000.1 - 0.02 15.3 0.0 0.056 13.9 0.0 1.8 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) ELO PF01151.18 EFA83001.1 - 1.1e-57 195.5 31.7 2e-56 191.3 31.7 2.0 1 1 0 1 1 1 1 GNS1/SUR4 family Ank_4 PF13637.6 EFA83002.1 - 1.3e-13 51.1 0.0 1e-07 32.4 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83002.1 - 6.2e-13 48.7 0.0 8.3e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83002.1 - 8.2e-10 39.1 0.0 1.1e-09 38.7 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA83002.1 - 3e-07 30.2 0.0 1.1e-06 28.5 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFA83002.1 - 3.6e-07 30.3 0.1 8.7e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat FNIP PF05725.12 EFA83003.1 - 2.6e-32 110.7 31.8 1.1e-11 44.7 0.5 9.0 5 2 5 11 11 11 8 FNIP Repeat FNIP PF05725.12 EFA83004.1 - 8e-30 102.7 25.8 1.2e-07 31.8 0.1 9.1 4 3 5 9 9 9 7 FNIP Repeat F-box_5 PF18511.1 EFA83004.1 - 1.3e-05 24.6 0.2 0.00015 21.2 0.2 2.2 2 0 0 2 2 2 1 F-box FNIP PF05725.12 EFA83005.1 - 3.1e-48 161.7 22.8 1.4e-10 41.2 1.2 7.7 7 0 0 7 7 7 6 FNIP Repeat F-box_5 PF18511.1 EFA83005.1 - 0.012 15.2 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 F-box FANCI_S1 PF14675.6 EFA83006.1 - 3e-25 89.1 9.2 1.3e-24 87.0 7.4 3.0 1 1 0 1 1 1 1 FANCI solenoid 1 FANCI_S4 PF14678.6 EFA83006.1 - 4.9e-18 65.2 8.5 3.4e-12 46.0 2.3 4.5 4 2 2 6 6 6 2 FANCI solenoid 4 DUF3452 PF11934.8 EFA83006.1 - 0.0084 15.7 1.5 0.0084 15.7 1.5 3.7 4 1 0 4 4 4 1 Domain of unknown function (DUF3452) SelK_SelG PF10961.8 EFA83006.1 - 4.4 8.0 7.1 28 5.4 0.0 3.7 4 0 0 4 4 4 0 Selenoprotein SelK_SelG DUF481 PF04338.12 EFA83007.1 - 0.032 14.3 0.8 0.085 12.9 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF481 RabGAP-TBC PF00566.18 EFA83008.1 - 5.9e-25 88.2 1.6 8.9e-25 87.6 0.4 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain zf-B_box PF00643.24 EFA83008.1 - 0.00012 22.2 5.6 0.00012 22.2 5.6 1.8 2 0 0 2 2 2 1 B-box zinc finger T4SS PF07996.11 EFA83008.1 - 0.041 14.3 0.1 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion system proteins ArfGap PF01412.18 EFA83008.1 - 0.066 13.3 1.8 0.15 12.1 1.8 1.6 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf zf-C3HC4_3 PF13920.6 EFA83008.1 - 2.4 8.1 8.5 0.18 11.7 3.6 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Kri1_C PF12936.7 EFA83009.1 - 1.3e-25 89.4 1.1 1.3e-25 89.4 1.1 5.3 6 2 2 8 8 8 1 KRI1-like family C-terminal NUC153 PF08159.12 EFA83010.1 - 9.9e-08 31.7 0.7 2.3e-07 30.5 0.7 1.7 1 0 0 1 1 1 1 NUC153 domain GEN1_C PF18380.1 EFA83010.1 - 1.1 10.1 4.5 3.3 8.7 4.5 1.7 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain ANAPC4_WD40 PF12894.7 EFA83011.1 - 2.3e-08 34.2 4.3 0.0014 18.9 0.1 5.1 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA83011.1 - 1.1e-07 32.4 13.4 0.00075 20.3 0.4 6.4 7 0 0 7 7 7 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 EFA83011.1 - 0.013 15.5 1.0 3.7 7.6 0.0 3.2 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Glyco_hydro_38N PF01074.22 EFA83012.1 - 2.3e-76 257.0 0.8 2.3e-76 257.0 0.8 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFA83012.1 - 2.7e-19 70.1 2.7 2.9e-19 70.0 0.4 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFA83012.1 - 5.7e-13 48.8 0.1 1.3e-12 47.7 0.1 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EFA83012.1 - 2.4e-09 37.2 0.4 6.5e-09 35.8 0.4 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Phospholip_B PF04916.13 EFA83013.1 - 4.8e-160 533.6 9.6 5.7e-160 533.4 9.6 1.0 1 0 0 1 1 1 1 Phospholipase B TLD PF07534.16 EFA83014.1 - 1.8e-37 128.7 2.4 1.8e-37 128.7 2.4 2.7 2 0 0 2 2 2 1 TLD LysM PF01476.20 EFA83014.1 - 0.0005 20.1 0.1 0.0021 18.1 0.1 2.1 1 0 0 1 1 1 1 LysM domain Amidase PF01425.21 EFA83014.1 - 0.0079 15.2 0.2 0.026 13.5 0.0 1.9 2 0 0 2 2 2 1 Amidase DUF4436 PF14494.6 EFA83014.1 - 0.088 12.1 0.0 0.26 10.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) SDA1 PF05285.12 EFA83014.1 - 4.1 6.7 29.1 0.28 10.6 17.8 3.2 3 0 0 3 3 3 0 SDA1 Methyltransf_12 PF08242.12 EFA83015.1 - 1.2 9.9 3.5 4 8.2 0.4 3.2 3 0 0 3 3 3 0 Methyltransferase domain Secretin_N_2 PF07655.13 EFA83015.1 - 3 8.4 17.0 2.1 8.9 9.7 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain Fcf2 PF08698.11 EFA83016.1 - 3.2e-21 75.5 4.6 1.3e-20 73.6 1.2 2.5 2 0 0 2 2 2 2 Fcf2 pre-rRNA processing Pkinase PF00069.25 EFA83017.1 - 4.9e-65 219.5 0.1 7.6e-65 218.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83017.1 - 5.5e-42 143.8 0.0 8.6e-42 143.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA83017.1 - 5.3e-08 32.5 0.0 1e-06 28.3 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFA83017.1 - 0.00039 19.3 0.8 0.00063 18.6 0.1 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFA83017.1 - 0.004 16.5 0.1 0.0067 15.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3429 PF11911.8 EFA83018.1 - 0.011 16.0 0.1 0.17 12.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3429) Zn_clus PF00172.18 EFA83019.1 - 6.4e-05 23.0 12.5 6.4e-05 23.0 12.5 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Complex1_LYR PF05347.15 EFA83021.1 - 4.7e-07 29.7 0.3 5.5e-07 29.5 0.3 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) SRP40_C PF05022.12 EFA83022.1 - 1.9e-15 57.5 4.5 1.9e-15 57.5 4.5 5.3 6 1 0 6 6 6 1 SRP40, C-terminal domain Glyco_tranf_2_4 PF13704.6 EFA83023.1 - 0.029 14.9 0.0 0.05 14.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Arm PF00514.23 EFA83025.1 - 1.7e-24 85.0 1.5 5.9e-11 42.0 0.2 5.7 5 1 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFA83025.1 - 1.1e-06 29.0 0.0 1.8e-05 25.1 0.0 2.8 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 EFA83025.1 - 5.7e-06 26.1 0.0 0.022 15.0 0.0 4.5 5 0 0 5 5 5 1 HEAT repeat RICTOR_V PF14668.6 EFA83025.1 - 0.00024 21.3 3.8 0.18 12.1 0.0 4.3 4 1 2 6 6 6 2 Rapamycin-insensitive companion of mTOR, domain 5 Rcd1 PF04078.13 EFA83025.1 - 0.0023 17.3 6.4 0.011 15.1 0.1 3.2 2 1 1 3 3 3 1 Cell differentiation family, Rcd1-like Proteasom_PSMB PF10508.9 EFA83025.1 - 0.0064 15.1 2.6 0.0085 14.6 0.9 1.9 1 1 0 2 2 2 1 Proteasome non-ATPase 26S subunit HEAT_2 PF13646.6 EFA83025.1 - 0.029 14.7 0.0 1.6 9.2 0.0 3.0 2 1 1 3 3 3 0 HEAT repeats FPL PF09758.9 EFA83025.1 - 0.038 14.0 5.9 0.13 12.3 2.1 3.0 1 1 1 2 2 2 0 Uncharacterised conserved protein AMP-binding PF00501.28 EFA83027.1 - 1e-55 189.1 0.0 1.7e-55 188.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Hyccin PF09790.9 EFA83027.1 - 3.8e-40 138.0 8.3 7e-40 137.1 8.3 1.5 1 0 0 1 1 1 1 Hyccin C1_2 PF03107.16 EFA83027.1 - 0.21 11.9 6.6 0.47 10.8 4.8 2.4 2 0 0 2 2 2 0 C1 domain DSPc PF00782.20 EFA83028.1 - 7.7e-29 100.2 0.0 1.1e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFA83028.1 - 6.5e-05 23.1 0.0 9.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFA83028.1 - 0.00017 21.2 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFA83028.1 - 0.14 12.1 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF1877 PF08974.10 EFA83028.1 - 0.2 11.8 0.0 0.3 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) VIR_N PF15912.5 EFA83029.1 - 0.14 11.7 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal CSN8_PSD8_EIF3K PF10075.9 EFA83030.1 - 1.2e-20 73.9 0.5 1.2e-20 73.9 0.5 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF3242 PF11586.8 EFA83030.1 - 0.03 14.1 0.5 0.1 12.4 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3242) PCI PF01399.27 EFA83030.1 - 0.032 14.7 1.1 0.053 14.0 0.1 1.8 2 0 0 2 2 2 0 PCI domain Response_reg PF00072.24 EFA83031.1 - 9.2e-22 77.3 1.9 8.1e-21 74.3 0.9 2.5 2 0 0 2 2 2 1 Response regulator receiver domain LRR_6 PF13516.6 EFA83031.1 - 3.6e-12 45.3 19.1 0.0096 15.9 0.1 7.6 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 EFA83031.1 - 3.7e-07 29.8 16.1 0.00013 21.6 0.1 4.9 3 1 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFA83031.1 - 1.1e-05 25.7 4.7 0.0032 17.8 0.0 6.1 5 2 2 7 7 7 5 Leucine Rich repeats (2 copies) Miff PF05644.11 EFA83031.1 - 0.092 12.4 10.3 0.17 11.5 10.3 1.4 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Presenilin PF01080.17 EFA83031.1 - 0.79 8.4 14.5 1.2 7.8 14.5 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 EFA83031.1 - 4 7.3 13.2 8.8 6.2 13.2 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UCH PF00443.29 EFA83032.1 - 6.9e-45 153.5 0.0 1e-44 153.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EFA83032.1 - 6.8e-20 70.6 0.0 3.1e-19 68.5 0.0 2.0 2 0 0 2 2 2 1 Variant UBP zinc finger UBA PF00627.31 EFA83032.1 - 2.9e-17 62.2 5.5 1.7e-09 37.3 1.0 3.0 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.19 EFA83032.1 - 1.6e-15 57.2 0.0 7.9e-15 54.9 0.0 2.2 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EFA83032.1 - 3.2e-13 50.0 0.1 1.3e-05 24.9 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 EFA83032.1 - 0.33 10.8 1.6 3.3 7.6 0.1 2.5 2 0 0 2 2 2 0 UBA-like domain Acyltransferase PF01553.21 EFA83033.1 - 8.5e-18 64.3 0.1 1.3e-17 63.7 0.1 1.3 1 0 0 1 1 1 1 Acyltransferase Lambda_Kil PF06301.11 EFA83033.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage lambda Kil protein Glyco_hydro_38N PF01074.22 EFA83034.1 - 1.7e-45 155.6 0.1 2.6e-45 155.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Pentapeptide PF00805.22 EFA83034.1 - 6.8e-42 140.6 37.1 3.4e-13 48.9 5.0 4.8 3 2 2 5 5 5 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFA83034.1 - 5.9e-24 84.0 4.6 1.1e-12 47.9 0.5 3.1 2 0 0 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFA83034.1 - 1.7e-17 63.3 7.3 5.5e-08 32.8 2.1 5.4 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFA83034.1 - 3.9e-17 62.4 0.0 1.3e-16 60.7 0.0 2.0 1 0 0 1 1 1 1 BTB/POZ domain KHA PF11834.8 EFA83034.1 - 4.3e-13 49.1 0.0 9.2e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel Alpha-mann_mid PF09261.11 EFA83034.1 - 6.8e-10 39.0 0.0 2.4e-09 37.2 0.1 1.9 2 0 0 2 2 2 1 Alpha mannosidase middle domain BTB_3 PF16017.5 EFA83034.1 - 0.00068 19.7 0.0 0.0024 18.0 0.0 2.0 1 0 0 1 1 1 1 BTB/POZ domain DRMBL PF07522.14 EFA83034.1 - 0.086 13.0 0.0 6.1 7.1 0.0 3.0 2 0 0 2 2 2 0 DNA repair metallo-beta-lactamase Glyco_transf_22 PF03901.17 EFA83035.1 - 3.1e-14 53.0 7.9 4.5e-14 52.5 7.9 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Ly49 PF08391.10 EFA83035.1 - 0.044 14.2 0.9 0.066 13.6 0.2 1.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region SelP_N PF04592.14 EFA83035.1 - 1.9 7.9 12.8 3 7.2 12.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Glyco_transf_22 PF03901.17 EFA83037.1 - 7.5e-10 38.6 0.3 9.1e-10 38.3 0.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Menin PF05053.13 EFA83037.1 - 0.036 12.4 3.8 0.04 12.3 3.8 1.0 1 0 0 1 1 1 0 Menin Serinc PF03348.15 EFA83037.1 - 0.13 11.1 0.2 0.17 10.8 0.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Macoilin PF09726.9 EFA83037.1 - 0.9 8.0 4.8 1.1 7.8 4.8 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EFA83037.1 - 6.1 5.5 5.6 0.7 8.6 1.9 1.4 2 0 0 2 2 2 0 Presenilin JAB PF01398.21 EFA83038.1 - 2.5e-34 117.8 2.3 3.9e-34 117.1 0.1 2.1 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EFA83038.1 - 2e-16 60.6 1.0 4.4e-16 59.6 1.0 1.6 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EFA83038.1 - 4.3e-06 26.5 0.3 4e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EFA83038.1 - 0.025 14.6 1.2 0.026 14.6 0.1 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) Myb_DNA-bind_6 PF13921.6 EFA83039.1 - 0.0056 16.9 0.7 0.02 15.1 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-C2H2 PF00096.26 EFA83039.1 - 0.082 13.4 1.9 0.19 12.3 0.4 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Myb_DNA-binding PF00249.31 EFA83039.1 - 0.097 12.9 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF3740 PF12548.8 EFA83039.1 - 0.16 12.4 5.8 1.5 9.3 0.1 2.8 3 0 0 3 3 3 0 Sulfatase protein SANT_DAMP1_like PF16282.5 EFA83039.1 - 0.16 12.2 0.1 0.36 11.0 0.1 1.5 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 TFIIA PF03153.13 EFA83039.1 - 0.17 11.9 49.6 0.17 11.9 18.8 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 EFA83040.1 - 4.7e-35 121.2 0.0 6.6e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83040.1 - 2.4e-19 69.6 0.0 3.6e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA83040.1 - 0.0094 15.3 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Dicty_CTDC PF00526.18 EFA83041.1 - 4.3e-50 167.2 172.6 1.2e-09 37.9 12.8 13.8 12 2 2 14 14 14 12 Dictyostelium (slime mold) repeat eIF-1a PF01176.19 EFA83042.1 - 1.1e-20 73.2 0.0 1.8e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 XRCC4 PF06632.12 EFA83043.1 - 6.2e-21 74.6 7.7 1.7e-15 56.7 6.2 2.1 2 0 0 2 2 2 2 DNA double-strand break repair and V(D)J recombination protein XRCC4 ZapB PF06005.12 EFA83043.1 - 0.0085 16.5 4.0 0.0085 16.5 4.0 2.0 2 1 0 2 2 2 1 Cell division protein ZapB CENP-F_leu_zip PF10473.9 EFA83043.1 - 0.0093 16.0 2.5 0.017 15.1 2.5 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3206 PF11472.8 EFA83043.1 - 0.015 15.2 2.8 2.9 7.9 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3206) HALZ PF02183.18 EFA83043.1 - 0.026 14.7 1.4 0.026 14.7 1.4 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper Prp19 PF08606.11 EFA83043.1 - 0.027 14.5 2.3 0.087 12.8 2.3 1.9 1 1 0 1 1 1 0 Prp19/Pso4-like bZIP_1 PF00170.21 EFA83043.1 - 0.057 13.5 0.6 0.15 12.2 0.3 1.8 1 1 0 1 1 1 0 bZIP transcription factor DUF3450 PF11932.8 EFA83043.1 - 0.13 11.6 2.8 0.21 10.9 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Rootletin PF15035.6 EFA83043.1 - 0.19 11.7 5.1 0.14 12.2 3.6 1.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DivIC PF04977.15 EFA83043.1 - 0.29 10.9 3.1 0.66 9.8 3.1 1.5 1 0 0 1 1 1 0 Septum formation initiator DRE2_N PF16803.5 EFA83043.1 - 4 7.7 7.4 0.81 9.9 2.2 2.2 1 1 1 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus 6PGD PF00393.19 EFA83044.1 - 6.8e-127 422.8 0.0 8.1e-127 422.5 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFA83044.1 - 3.1e-53 180.2 0.1 4.4e-53 179.7 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EFA83044.1 - 0.0055 16.8 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase HpuA PF16960.5 EFA83044.1 - 0.17 11.0 1.5 0.33 10.1 0.5 1.9 2 0 0 2 2 2 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter TPP_enzyme_N PF02776.18 EFA83045.1 - 5.7e-48 162.8 0.0 1.7e-47 161.3 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EFA83045.1 - 1.6e-23 83.2 0.0 8.8e-23 80.8 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFA83045.1 - 1.6e-17 63.6 0.0 5e-17 61.9 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain MgsA_C PF12002.8 EFA83046.1 - 4e-56 189.5 0.1 4e-56 189.5 0.1 2.2 2 0 0 2 2 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EFA83046.1 - 1.5e-24 86.2 0.1 1.7e-23 82.7 0.1 2.7 2 0 0 2 2 2 1 AAA C-terminal domain AAA PF00004.29 EFA83046.1 - 1.4e-14 54.6 0.0 3.6e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFA83046.1 - 1.8e-11 44.0 0.0 8.3e-11 41.9 0.0 1.9 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFA83046.1 - 2.1e-07 31.0 0.0 5.8e-06 26.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFA83046.1 - 1e-06 29.2 0.2 0.0007 20.0 0.0 2.6 2 1 1 3 3 2 2 AAA ATPase domain AAA_14 PF13173.6 EFA83046.1 - 1.1e-06 28.8 0.4 3.4e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EFA83046.1 - 5.1e-06 26.3 0.0 0.00011 22.0 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_2 PF07724.14 EFA83046.1 - 7.3e-06 26.2 0.0 0.00046 20.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 EFA83046.1 - 0.00016 21.8 0.0 0.00042 20.5 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFA83046.1 - 0.00032 20.2 0.1 0.28 10.6 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EFA83046.1 - 0.00063 20.0 0.2 0.099 12.9 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA83046.1 - 0.005 17.4 0.0 0.005 17.4 0.0 2.8 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.13 EFA83046.1 - 0.0051 16.1 0.0 0.0096 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 EFA83046.1 - 0.0066 16.2 0.4 0.025 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFA83046.1 - 0.011 16.1 0.3 4.2 7.7 0.1 2.6 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 EFA83046.1 - 0.014 15.9 0.3 0.089 13.2 0.0 2.3 2 1 1 3 3 2 0 AAA domain AAA_33 PF13671.6 EFA83046.1 - 0.02 15.0 0.0 0.044 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFA83046.1 - 0.025 13.9 0.0 0.049 12.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 EFA83046.1 - 0.033 14.7 1.0 0.12 12.9 0.0 2.4 2 1 0 2 2 2 0 ABC transporter NB-ARC PF00931.22 EFA83046.1 - 0.036 13.2 0.0 0.073 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 EFA83046.1 - 0.044 13.5 0.0 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFA83046.1 - 0.096 12.4 0.0 0.57 9.9 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 EFA83046.1 - 0.19 11.5 0.1 0.19 11.5 0.1 2.6 3 1 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Kelch_6 PF13964.6 EFA83048.1 - 5.5e-13 48.7 2.9 1.4e-06 28.3 0.1 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 EFA83048.1 - 0.011 15.7 2.1 5.2 7.2 0.1 3.5 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA83048.1 - 0.031 14.3 2.7 0.46 10.5 0.0 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA83048.1 - 0.1 12.6 1.9 9.1 6.4 0.0 3.8 3 1 0 3 3 3 0 Kelch motif zf-B_box PF00643.24 EFA83048.1 - 0.3 11.3 13.2 0.72 10.1 13.2 1.6 1 0 0 1 1 1 0 B-box zinc finger Kelch_1 PF01344.25 EFA83048.1 - 5.8 6.6 10.7 0.8 9.3 0.2 3.9 4 1 0 4 4 4 0 Kelch motif MIEAP PF16026.5 EFA83048.1 - 8.1 6.6 7.8 3.3 7.9 3.2 2.2 2 0 0 2 2 2 0 Mitochondria-eating protein SVWC PF15430.6 EFA83049.1 - 3.9e-07 30.2 7.5 5.5e-07 29.8 7.5 1.3 1 0 0 1 1 1 1 Single domain von Willebrand factor type C ETRAMP PF09716.10 EFA83049.1 - 0.03 14.4 0.1 0.034 14.2 0.1 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) GDP_Man_Dehyd PF16363.5 EFA83050.1 - 1.8e-06 27.6 0.1 0.005 16.3 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFA83050.1 - 2.2e-06 27.3 0.1 0.00016 21.2 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EFA83050.1 - 7.2e-05 22.7 1.6 0.081 12.8 0.0 2.6 2 1 1 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 EFA83050.1 - 0.00048 19.6 0.1 0.00079 18.9 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EFA83050.1 - 0.0012 18.7 0.0 0.0021 17.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_2 PF03446.15 EFA83050.1 - 0.0026 18.0 0.0 0.0054 16.9 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DFP PF04127.15 EFA83050.1 - 0.0037 17.1 0.3 0.012 15.5 0.0 1.8 2 0 0 2 2 2 1 DNA / pantothenate metabolism flavoprotein NmrA PF05368.13 EFA83050.1 - 0.0044 16.6 0.5 0.047 13.2 0.1 2.2 2 0 0 2 2 2 1 NmrA-like family TrkA_N PF02254.18 EFA83050.1 - 0.0061 16.8 0.3 0.014 15.6 0.3 1.6 1 0 0 1 1 1 1 TrkA-N domain ADH_zinc_N PF00107.26 EFA83050.1 - 0.054 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Rotamase PF00639.21 EFA83051.1 - 1e-24 87.3 0.1 1.7e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EFA83051.1 - 1.2e-21 77.3 0.1 2.1e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain FHA PF00498.26 EFA83051.1 - 2.6e-19 69.3 0.2 2.8e-18 66.0 0.0 2.2 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EFA83051.1 - 3.4e-07 30.5 0.3 2.4e-06 27.8 0.0 2.3 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain Rotamase_2 PF13145.6 EFA83051.1 - 0.01 16.7 0.0 0.015 16.1 0.0 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain ABC_tran_CTD PF16326.5 EFA83053.1 - 0.0094 16.2 1.8 0.0098 16.1 0.4 1.7 2 0 0 2 2 2 1 ABC transporter C-terminal domain MSA-2c PF12238.8 EFA83053.1 - 0.014 15.4 4.4 0.014 15.4 4.4 2.2 1 1 1 2 2 2 0 Merozoite surface antigen 2c Lipoprotein_2 PF00921.17 EFA83053.1 - 0.024 14.2 8.3 0.027 14.0 8.3 1.0 1 0 0 1 1 1 0 Borrelia lipoprotein Fib_alpha PF08702.10 EFA83053.1 - 0.025 14.7 4.1 0.34 11.1 3.3 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Tht1 PF04163.12 EFA83053.1 - 0.032 13.0 0.2 0.038 12.8 0.2 1.0 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein PAS_10 PF13596.6 EFA83053.1 - 0.12 13.0 0.8 0.2 12.3 0.5 1.5 1 1 1 2 2 2 0 PAS domain Paralemmin PF03285.15 EFA83053.1 - 0.17 11.5 7.5 0.15 11.6 6.1 1.6 1 1 0 1 1 1 0 Paralemmin MIS13 PF08202.11 EFA83053.1 - 0.2 10.9 3.3 0.26 10.5 3.3 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family BMFP PF04380.13 EFA83053.1 - 0.25 11.8 2.4 11 6.5 0.1 3.1 2 1 1 3 3 3 0 Membrane fusogenic activity DUF1690 PF07956.11 EFA83053.1 - 0.45 10.9 5.2 8.7 6.8 1.5 2.2 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Dicty_REP PF05086.12 EFA83053.1 - 0.74 7.7 11.5 0.87 7.5 11.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein GET2 PF08690.10 EFA83053.1 - 1.1 8.9 8.1 1.3 8.6 8.1 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 MSP1_C PF07462.11 EFA83053.1 - 2.3 6.8 7.1 2.5 6.7 7.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus CBP_CCPA PF17040.5 EFA83053.1 - 7.7 7.1 12.1 0.086 13.4 1.1 2.1 1 1 1 2 2 2 0 Cellulose-complementing protein A DIM1 PF02966.16 EFA83054.1 - 9.5e-65 216.4 0.3 1.1e-64 216.2 0.3 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EFA83054.1 - 0.00078 19.4 0.1 0.0011 18.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Myb_DNA-binding PF00249.31 EFA83055.1 - 2.8e-12 46.6 0.0 1.8e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 EFA83055.1 - 1.4e-09 37.6 6.7 2.8e-09 36.7 6.7 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 EFA83055.1 - 7e-09 35.9 0.1 2.6e-08 34.1 0.1 2.0 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 EFA83055.1 - 0.00033 20.8 0.0 0.0013 18.9 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain YqcI_YcgG PF08892.11 EFA83055.1 - 0.013 15.3 0.3 0.028 14.2 0.3 1.5 1 0 0 1 1 1 0 YqcI/YcgG family C1_2 PF03107.16 EFA83055.1 - 0.019 15.3 5.7 0.042 14.2 5.7 1.5 1 0 0 1 1 1 0 C1 domain Patatin PF01734.22 EFA83055.1 - 2.4 8.3 9.6 0.88 9.7 1.4 2.5 2 0 0 2 2 2 0 Patatin-like phospholipase HD_3 PF13023.6 EFA83056.1 - 1.3e-45 155.3 0.1 1.5e-45 155.0 0.1 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EFA83056.1 - 2.1e-15 57.0 0.1 2.5e-15 56.7 0.1 1.1 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EFA83056.1 - 2.2e-06 27.9 0.0 3.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 HD domain APAF1_C PF17908.1 EFA83056.1 - 0.046 13.7 0.4 0.22 11.5 0.2 1.9 1 1 1 2 2 2 0 APAF-1 helical domain PH PF00169.29 EFA83057.1 - 7.8e-13 48.8 0.1 2.7e-12 47.1 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EFA83057.1 - 0.002 18.6 0.8 0.12 12.8 0.8 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain DUF1689 PF07954.11 EFA83058.1 - 0.078 13.4 0.0 0.095 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) zf-C2H2_jaz PF12171.8 EFA83059.1 - 1.9e-10 40.7 2.6 1.9e-10 40.7 2.6 1.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFA83059.1 - 9.8e-05 22.6 1.4 0.00022 21.5 1.4 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 EFA83059.1 - 0.0058 16.4 1.4 0.017 14.8 1.4 1.8 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_2 PF12756.7 EFA83059.1 - 0.0071 16.7 0.7 0.0095 16.3 0.2 1.5 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFA83059.1 - 0.15 12.5 1.4 0.29 11.7 1.4 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type CBF PF03914.17 EFA83060.1 - 3e-31 108.8 0.2 3e-31 108.8 0.2 2.4 2 1 0 2 2 2 1 CBF/Mak21 family DUF1512 PF07431.12 EFA83060.1 - 0.22 10.5 3.4 0.44 9.5 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) Terminase_3C PF17288.2 EFA83060.1 - 0.37 11.2 5.4 0.24 11.8 3.0 2.0 2 0 0 2 2 2 0 Terminase RNAseH like domain Pur_ac_phosph_N PF16656.5 EFA83061.1 - 6e-20 71.6 1.0 1.3e-19 70.5 0.4 1.9 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EFA83061.1 - 1.4e-18 68.1 4.1 2.2e-18 67.5 4.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFA83061.1 - 4.2e-16 59.6 0.1 9.3e-16 58.4 0.1 1.6 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Kelch_6 PF13964.6 EFA83062.1 - 0.0054 17.0 0.2 0.0088 16.3 0.2 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 EFA83063.1 - 3e-06 27.3 0.2 1.1e-05 25.6 0.0 2.1 2 0 0 2 2 2 1 Kelch motif zf-B_box PF00643.24 EFA83063.1 - 0.0035 17.5 12.4 0.0087 16.2 12.4 1.6 1 0 0 1 1 1 1 B-box zinc finger Nup54 PF13874.6 EFA83063.1 - 0.026 14.6 1.0 0.048 13.8 1.0 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Kelch_4 PF13418.6 EFA83063.1 - 0.068 13.2 0.4 0.28 11.2 0.1 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA83063.1 - 0.071 12.7 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 Kelch motif Jnk-SapK_ap_N PF09744.9 EFA83063.1 - 0.09 13.0 0.9 0.19 12.0 0.9 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 CytadhesinP1 PF12378.8 EFA83063.1 - 0.65 10.2 0.1 0.65 10.2 0.1 3.5 3 0 0 3 3 3 0 Trypsin-sensitive surface-exposed protein Uso1_p115_C PF04871.13 EFA83063.1 - 2 8.8 5.2 1.2 9.6 2.8 1.8 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region COMM_domain PF07258.14 EFA83064.1 - 6.3e-18 64.7 0.2 1.1e-17 64.0 0.2 1.3 1 0 0 1 1 1 1 COMM domain Phage_CRI PF05144.14 EFA83064.1 - 0.065 12.6 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Phage replication protein CRI SRP_TPR_like PF17004.5 EFA83065.1 - 5.9e-17 61.8 21.3 2e-15 56.8 6.9 4.0 3 1 1 4 4 4 2 Putative TPR-like repeat SRP72 PF08492.12 EFA83065.1 - 1.1e-12 48.2 8.0 1.1e-12 48.2 8.0 2.9 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EFA83065.1 - 9.9e-11 42.0 9.3 0.0027 18.2 0.7 5.9 6 1 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA83065.1 - 2.5e-10 40.5 27.5 2.2e-07 31.0 7.1 6.3 2 2 5 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EFA83065.1 - 5.3e-09 35.5 25.7 0.12 12.3 0.0 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA83065.1 - 2.9e-08 33.2 22.9 0.18 12.0 0.3 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFA83065.1 - 6e-08 32.8 7.5 0.53 11.0 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat PPR PF01535.20 EFA83065.1 - 9e-06 25.6 1.8 1.8 9.0 0.0 6.7 7 0 0 7 7 7 1 PPR repeat TPR_7 PF13176.6 EFA83065.1 - 1.4e-05 24.7 8.6 1.2 9.3 0.0 6.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA83065.1 - 8.8e-05 22.7 12.2 1.5 9.2 2.3 6.8 7 2 0 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA83065.1 - 9.9e-05 22.3 25.1 2.9 8.3 0.0 7.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EFA83065.1 - 0.00058 19.3 4.9 0.18 11.1 0.4 3.8 2 1 0 3 3 3 1 MalT-like TPR region TPR_16 PF13432.6 EFA83065.1 - 0.0025 18.4 0.0 3.1 8.5 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFA83065.1 - 0.024 14.3 0.3 2.9 7.5 0.0 3.8 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) ketoacyl-synt PF00109.26 EFA83065.1 - 0.038 13.6 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain DUF4810 PF16068.5 EFA83065.1 - 0.6 10.7 0.0 0.6 10.7 0.0 4.3 5 3 0 5 5 5 0 Domain of unknown function (DUF4810) AMP-binding PF00501.28 EFA83066.1 - 7.5e-17 61.0 0.0 1.5e-16 60.0 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme Terminase_3C PF17288.2 EFA83066.1 - 0.12 12.8 0.2 0.45 10.9 0.1 2.0 2 0 0 2 2 2 0 Terminase RNAseH like domain Kelch_6 PF13964.6 EFA83068.1 - 1.8e-10 40.7 5.5 0.00013 22.1 0.1 5.2 5 1 1 6 6 6 2 Kelch motif Kelch_4 PF13418.6 EFA83068.1 - 0.071 13.1 0.1 2.4 8.3 0.0 3.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA83068.1 - 0.24 11.0 0.9 11 5.7 0.0 3.3 4 0 0 4 4 4 0 Kelch motif A_thal_3526 PF09713.10 EFA83070.1 - 4.6e-19 68.4 0.4 9.2e-19 67.4 0.4 1.5 1 0 0 1 1 1 1 Plant protein 1589 of unknown function (A_thal_3526) TMEM151 PF14857.6 EFA83070.1 - 4 6.3 7.1 20 4.0 7.0 2.0 1 1 0 1 1 1 0 TMEM151 family RNase_P_Rpp14 PF01900.19 EFA83071.1 - 1.4e-20 73.4 0.4 2e-20 72.9 0.4 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family Presenilin PF01080.17 EFA83071.1 - 0.00081 18.3 4.1 0.001 17.9 4.1 1.2 1 0 0 1 1 1 1 Presenilin Neur_chan_memb PF02932.16 EFA83071.1 - 8.5 6.4 7.1 11 6.0 7.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LIM PF00412.22 EFA83072.1 - 3.4e-10 40.0 10.7 5.2e-10 39.4 10.7 1.3 1 0 0 1 1 1 1 LIM domain Gaa1 PF04114.14 EFA83073.1 - 6.1e-44 150.9 16.8 6.1e-44 150.9 16.8 2.3 2 1 0 2 2 2 1 Gaa1-like, GPI transamidase component WD40 PF00400.32 EFA83074.1 - 6.5e-09 36.3 0.6 0.0033 18.2 0.1 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83074.1 - 0.056 13.7 0.1 4.3 7.7 0.0 2.7 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain FAM176 PF14851.6 EFA83074.1 - 2.1 8.0 7.7 13 5.4 5.3 2.2 2 0 0 2 2 2 0 FAM176 family SET PF00856.28 EFA83075.1 - 5.8e-10 39.8 4.6 5.8e-10 39.8 4.6 2.3 2 1 0 2 2 2 1 SET domain Cep57_CLD_2 PF14197.6 EFA83075.1 - 0.0099 15.9 0.1 0.025 14.6 0.1 1.7 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 Ribosomal_L31e PF01198.19 EFA83075.1 - 0.018 15.3 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L31e CTU2 PF10288.9 EFA83075.1 - 0.91 9.8 11.9 0.18 12.1 4.4 2.6 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF4282 PF14110.6 EFA83077.1 - 1.2e-15 58.0 8.4 1.5e-15 57.7 8.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4282) WD40 PF00400.32 EFA83078.1 - 7.6e-24 83.5 2.4 5.4e-06 27.0 0.0 6.8 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83078.1 - 9.6e-14 51.5 0.0 0.035 14.4 0.0 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFA83078.1 - 0.00011 22.1 0.9 0.45 10.4 1.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFA83078.1 - 0.00045 19.3 0.3 0.3 10.0 0.0 3.0 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EFA83078.1 - 0.005 15.2 0.0 0.02 13.2 0.0 1.8 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 EFA83078.1 - 0.022 13.4 0.8 1.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFA83078.1 - 0.04 12.4 0.0 0.13 10.8 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ank_2 PF12796.7 EFA83080.1 - 3.8e-34 117.1 28.8 3e-05 24.5 0.2 9.7 2 2 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83080.1 - 4.4e-30 103.7 24.4 5e-05 23.8 0.0 12.0 8 3 6 14 14 14 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83080.1 - 2.7e-24 84.9 17.2 0.18 12.2 0.1 16.0 7 4 11 18 18 18 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83080.1 - 3.5e-18 63.8 21.0 8.7 7.3 0.0 18.3 19 1 2 21 21 21 2 Ankyrin repeat DUF5049 PF16468.5 EFA83080.1 - 0.00033 20.5 7.1 11 6.0 0.0 7.6 7 2 2 9 9 9 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA83080.1 - 0.014 15.9 9.7 65 4.2 0.0 8.4 10 0 0 10 10 10 0 Ankyrin repeat Ank_2 PF12796.7 EFA83081.1 - 2.9e-20 72.6 0.0 5.6e-14 52.5 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83081.1 - 1.1e-19 70.5 0.3 1.2e-06 28.9 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83081.1 - 3.4e-14 52.7 0.0 3.7e-08 33.5 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA83081.1 - 6e-10 39.1 0.2 0.0006 20.2 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EFA83081.1 - 2.5e-09 36.6 0.0 8.8e-05 22.6 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat MOZ_SAS PF01853.18 EFA83082.1 - 1.6e-52 177.8 0.0 1.9e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 EFA83082.1 - 0.014 15.8 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA83082.1 - 0.027 14.5 0.0 0.092 12.7 0.0 1.8 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_1 PF00583.25 EFA83082.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family CNP_C_terminal PF17839.1 EFA83082.1 - 0.2 12.4 0.0 0.28 12.0 0.0 1.2 1 0 0 1 1 1 0 C-terminal domain of cyclic nucleotide phosphodiesterase Tudor-knot PF11717.8 EFA83083.1 - 9.7e-20 70.2 0.9 1.6e-19 69.5 0.9 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 EFA83083.1 - 0.0077 16.1 0.5 0.12 12.4 0.2 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain zf-MYST PF17772.1 EFA83083.1 - 0.071 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 MYST family zinc finger domain Mito_carr PF00153.27 EFA83084.1 - 1.2e-52 175.7 4.5 8.8e-18 64.0 0.7 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_13 PF17958.1 EFA83088.1 - 2.1e-06 27.5 0.0 4.3e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain Pox_P35 PF03213.14 EFA83088.1 - 0.012 14.8 2.2 0.016 14.5 2.2 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein GW PF13457.6 EFA83088.1 - 0.029 15.0 1.2 0.087 13.4 0.0 2.3 2 0 0 2 2 2 0 GW (Gly-Tryp) dipeptide domain INTAP PF16617.5 EFA83088.1 - 0.096 13.0 0.5 1 9.8 0.3 2.2 2 0 0 2 2 2 0 Intersectin and clathrin adaptor AP2 binding region LRR_8 PF13855.6 EFA83089.1 - 1.3e-28 98.6 52.9 1.4e-07 31.1 0.4 6.4 5 2 0 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFA83089.1 - 7.3e-13 48.5 81.9 0.00016 22.0 4.6 9.0 9 1 1 10 10 7 6 Leucine Rich repeats (2 copies) V_ATPase_I PF01496.19 EFA83089.1 - 0.0013 16.7 4.2 0.0013 16.7 4.2 2.4 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family EPL1 PF10513.9 EFA83089.1 - 0.012 16.0 9.1 0.012 16.0 9.1 3.8 2 1 0 2 2 1 0 Enhancer of polycomb-like DUF5327 PF17261.2 EFA83089.1 - 0.016 15.9 16.6 0.016 15.9 16.6 3.4 3 1 0 3 3 2 0 Family of unknown function (DUF5327) Tim54 PF11711.8 EFA83089.1 - 0.18 10.5 20.4 0.018 13.8 4.3 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4746 PF15928.5 EFA83089.1 - 0.55 9.6 15.5 0.072 12.5 5.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Vfa1 PF08432.10 EFA83089.1 - 2.1 8.6 30.1 1.3 9.3 11.0 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2052 PF09747.9 EFA83089.1 - 4.3 7.4 23.2 5 7.2 11.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4637 PF15470.6 EFA83089.1 - 5.9 6.6 15.8 0.79 9.4 2.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Connexin PF00029.19 EFA83089.1 - 7.4 6.3 20.0 0.21 11.3 6.5 2.4 2 0 0 2 2 2 0 Connexin LRR_1 PF00560.33 EFA83089.1 - 8.7 7.3 54.6 12 6.9 0.5 12.7 11 1 1 12 12 11 0 Leucine Rich Repeat ABC2_membrane_2 PF12679.7 EFA83090.1 - 0.0014 18.0 5.2 0.0014 18.0 5.2 2.1 2 1 1 3 3 3 1 ABC-2 family transporter protein DUF3302 PF11742.8 EFA83090.1 - 1 9.5 5.6 0.25 11.5 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) Orf78 PF06024.12 EFA83090.1 - 2 8.8 0.0 2 8.8 0.0 4.2 4 2 1 5 5 5 0 Orf78 (ac78) DUF92 PF01940.16 EFA83091.1 - 8.1e-79 264.4 3.1 1.1e-78 264.0 3.1 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 EI24 PF07264.11 EFA83091.1 - 0.0035 17.6 1.2 0.0035 17.6 1.2 2.2 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) DUF1345 PF07077.11 EFA83091.1 - 0.008 15.9 1.3 0.012 15.4 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1345) Peptidase_M56 PF05569.11 EFA83091.1 - 0.023 13.9 0.6 0.032 13.4 0.6 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 BCD PF15461.6 EFA83091.1 - 0.042 13.3 1.7 0.076 12.5 1.7 1.4 1 0 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase CbtA PF09490.10 EFA83091.1 - 0.073 12.8 0.0 0.073 12.8 0.0 2.4 2 1 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) DUF4131 PF13567.6 EFA83091.1 - 0.54 9.9 4.1 4.9 6.8 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) DUF4064 PF13273.6 EFA83091.1 - 1.8 8.9 16.2 0.076 13.3 0.7 3.9 4 1 0 4 4 4 0 Protein of unknown function (DUF4064) Tmemb_14 PF03647.13 EFA83091.1 - 2.3 9.0 12.0 1.1 10.0 0.1 3.9 2 2 1 3 3 3 0 Transmembrane proteins 14C Cpn60_TCP1 PF00118.24 EFA83092.1 - 4.2e-149 497.3 13.2 5.5e-149 496.9 13.2 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dus PF01207.17 EFA83092.1 - 2.1e-59 201.2 0.1 3.7e-59 200.3 0.1 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 EFA83092.1 - 0.02 14.2 1.7 0.034 13.5 0.1 2.2 3 1 0 3 3 3 0 Thiamine monophosphate synthase FYVE PF01363.21 EFA83092.1 - 0.048 13.8 0.5 0.14 12.3 0.5 1.8 1 0 0 1 1 1 0 FYVE zinc finger AAA_23 PF13476.6 EFA83093.1 - 0.0014 19.1 3.8 0.1 13.1 0.1 2.8 2 1 0 2 2 2 2 AAA domain DUF3801 PF12687.7 EFA83093.1 - 0.0033 17.5 1.7 0.0054 16.8 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3801) AAA_16 PF13191.6 EFA83093.1 - 0.0055 17.1 0.0 0.01 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain TERB2 PF15101.6 EFA83093.1 - 0.015 15.4 2.9 0.026 14.6 2.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 AAA_19 PF13245.6 EFA83093.1 - 0.046 14.0 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFA83093.1 - 0.08 13.2 0.0 0.33 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain Bac_DnaA PF00308.18 EFA83093.1 - 0.093 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein RPN2_C PF18004.1 EFA83093.1 - 0.85 9.5 7.2 1.7 8.5 7.2 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain 7tm_3 PF00003.22 EFA83094.1 - 5e-43 147.5 25.0 5e-43 147.5 25.0 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 EFA83094.1 - 1.5e-39 136.1 0.0 3.1e-39 135.1 0.0 1.5 1 0 0 1 1 1 1 Receptor family ligand binding region Lipase_3 PF01764.25 EFA83094.1 - 2e-21 76.4 0.0 5.5e-21 74.9 0.0 1.8 1 0 0 1 1 1 1 Lipase (class 3) Peripla_BP_6 PF13458.6 EFA83094.1 - 7.3e-13 48.9 0.1 1.3e-12 48.1 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Ank_4 PF13637.6 EFA83095.1 - 1.2e-37 127.8 30.3 9e-05 23.0 0.3 12.7 9 3 4 14 14 14 11 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83095.1 - 3.9e-34 117.1 33.4 2.4e-06 28.0 0.2 10.5 4 3 6 11 11 11 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83095.1 - 2.1e-25 88.4 30.7 0.0044 17.3 0.1 15.4 6 4 11 17 17 17 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83095.1 - 2.3e-15 55.2 24.2 14 6.7 0.0 16.9 18 2 2 20 20 20 6 Ankyrin repeat Ank PF00023.30 EFA83095.1 - 0.0012 19.1 10.0 1.4e+02 3.1 0.0 9.6 8 3 0 8 8 8 0 Ankyrin repeat DUF5049 PF16468.5 EFA83095.1 - 0.049 13.5 5.8 29 4.7 0.0 7.0 7 1 1 8 8 8 0 Domain of unknown function (DUF5049) HEAT PF02985.22 EFA83096.1 - 1.5e-09 37.3 0.4 0.032 14.5 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EFA83096.1 - 0.0018 18.7 0.1 32 5.2 0.0 5.7 7 0 0 7 7 7 1 HEAT-like repeat HEAT_2 PF13646.6 EFA83096.1 - 0.018 15.4 0.0 25 5.4 0.0 5.0 5 0 0 5 5 5 0 HEAT repeats DUF4516 PF14990.6 EFA83096.1 - 0.12 12.2 0.1 0.36 10.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4516) Cnd1 PF12717.7 EFA83096.1 - 2.2 8.3 5.4 8 6.5 0.1 4.5 6 0 0 6 6 6 0 non-SMC mitotic condensation complex subunit 1 RhoGEF PF00621.20 EFA83098.1 - 2.4e-33 115.9 5.1 4.1e-33 115.2 5.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PRTP PF01366.18 EFA83098.1 - 0.079 11.0 0.2 0.13 10.3 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Chorein_N PF12624.7 EFA83100.1 - 9.9e-21 74.0 1.8 9.9e-21 74.0 1.8 3.7 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 Ribosomal_60s PF00428.19 EFA83100.1 - 0.0033 18.0 1.8 0.0058 17.2 0.1 2.4 2 0 0 2 2 2 1 60s Acidic ribosomal protein Chalcone_2 PF16035.5 EFA83100.1 - 0.012 15.4 5.4 1.4 8.7 0.2 3.0 2 0 0 2 2 2 0 Chalcone isomerase like HDV_ag PF01517.18 EFA83100.1 - 1.5 8.5 8.4 0.079 12.8 2.2 2.0 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen Golgin_A5 PF09787.9 EFA83100.1 - 3.6 6.9 23.4 0.06 12.8 12.5 2.9 3 0 0 3 3 3 0 Golgin subfamily A member 5 Meth_synt_2 PF01717.18 EFA83101.1 - 1.1e-13 51.2 0.0 6.5e-13 48.7 0.0 2.0 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain FAD_binding_3 PF01494.19 EFA83102.1 - 1.8e-22 80.1 0.0 4.6e-11 42.6 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.14 EFA83102.1 - 3.8e-08 32.6 0.1 0.0073 15.2 0.0 3.3 4 0 0 4 4 4 3 Tryptophan halogenase SE PF08491.10 EFA83102.1 - 1e-07 31.3 0.1 1.8e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EFA83102.1 - 1.3e-05 24.6 0.1 0.00084 18.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA83102.1 - 3.9e-05 22.9 0.7 0.0021 17.2 0.6 2.8 2 1 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EFA83102.1 - 0.00018 21.2 0.1 0.0012 18.5 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA83102.1 - 0.013 15.7 0.2 0.033 14.4 0.2 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFA83102.1 - 0.017 15.1 0.2 0.63 10.0 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EFA83102.1 - 0.027 15.0 0.0 0.088 13.4 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFA83102.1 - 0.029 13.1 1.8 0.56 8.8 0.2 2.2 2 0 0 2 2 2 0 HI0933-like protein Presenilin PF01080.17 EFA83103.1 - 1.2e-110 370.0 11.4 1.2e-110 370.0 11.4 2.1 2 0 0 2 2 2 1 Presenilin TIG PF01833.24 EFA83103.1 - 1e-59 198.6 70.3 2.6e-12 46.6 1.3 11.9 11 1 0 11 11 11 9 IPT/TIG domain DNase_II PF03265.15 EFA83103.1 - 8e-30 104.2 0.4 8e-30 104.2 0.4 3.2 2 1 0 2 2 2 1 Deoxyribonuclease II PPC PF04151.15 EFA83103.1 - 1 10.5 6.3 1 10.5 0.0 3.8 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain Ly49 PF08391.10 EFA83104.1 - 0.0081 16.5 0.6 0.0099 16.2 0.6 1.1 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Med12 PF09497.10 EFA83105.1 - 0.084 13.2 0.1 20 5.6 0.0 2.8 3 0 0 3 3 3 0 Transcription mediator complex subunit Med12 DUF4745 PF15923.5 EFA83105.1 - 6.3 6.8 9.0 1.6 8.7 4.8 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4745) FNIP PF05725.12 EFA83106.1 - 1.2e-34 118.2 41.4 2.1e-09 37.4 0.2 9.3 8 1 2 10 10 10 8 FNIP Repeat F-box-like PF12937.7 EFA83106.1 - 0.0027 17.6 0.2 0.0064 16.4 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA83106.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 F-box HORMA PF02301.18 EFA83107.1 - 1.2e-22 80.6 0.3 2.7e-22 79.4 0.3 1.5 1 1 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 EFA83107.1 - 0.00012 21.9 0.4 0.00083 19.2 0.4 2.2 1 1 0 1 1 1 1 Bacterial HORMA domain 2 IMPa_N_2 PF18650.1 EFA83107.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Immunomodulating metalloprotease N-terminal domain ATG101 PF07855.12 EFA83107.1 - 0.04 13.9 0.1 0.67 9.9 0.1 2.1 1 1 0 1 1 1 0 Autophagy-related protein 101 DUF4538 PF15061.6 EFA83108.1 - 0.15 11.8 2.7 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) FAD_binding_3 PF01494.19 EFA83109.1 - 1.4e-22 80.5 0.0 2.3e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFA83109.1 - 7.5e-05 22.9 0.0 0.00016 21.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EFA83109.1 - 0.0078 15.3 0.0 0.07 12.2 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EFA83109.1 - 0.008 15.4 0.0 0.074 12.3 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_S25 PF03297.15 EFA83109.1 - 0.39 11.0 1.8 24 5.2 0.1 3.2 3 1 0 3 3 3 0 S25 ribosomal protein PCRF PF03462.18 EFA83110.1 - 1.6e-58 197.8 0.8 1.6e-58 197.8 0.8 1.8 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EFA83110.1 - 7.3e-39 132.3 2.8 7.3e-39 132.3 2.8 2.6 2 1 0 2 2 2 1 RF-1 domain Njmu-R1 PF15053.6 EFA83111.1 - 1.1e-28 100.4 7.8 8.6e-26 90.9 3.4 3.2 3 0 0 3 3 3 3 Mjmu-R1-like protein family FNIP PF05725.12 EFA83112.1 - 1.3e-19 70.0 13.1 7e-12 45.3 0.1 4.1 3 1 0 3 3 3 2 FNIP Repeat F-box_5 PF18511.1 EFA83112.1 - 3.7e-05 23.2 0.0 6.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA83112.1 - 0.0037 17.1 0.0 0.008 16.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like Promethin PF16015.5 EFA83113.1 - 0.35 10.8 9.1 1.2 9.1 9.1 2.0 1 0 0 1 1 1 0 Promethin DDE_Tnp_1_7 PF13843.6 EFA83114.1 - 0.0051 16.2 0.0 0.0051 16.2 0.0 1.0 1 0 0 1 1 1 1 Transposase IS4 Peptidase_C48 PF02902.19 EFA83115.1 - 0.00033 20.6 5.2 0.0012 18.7 0.2 3.4 2 1 1 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain Syntaxin_2 PF14523.6 EFA83115.1 - 0.068 13.6 2.4 0.39 11.1 1.8 2.4 2 0 0 2 2 2 0 Syntaxin-like protein CENP-B_dimeris PF09026.10 EFA83115.1 - 0.073 13.5 7.0 0.065 13.6 4.9 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Fzo_mitofusin PF04799.13 EFA83115.1 - 0.093 12.3 2.6 0.18 11.4 2.6 1.4 1 0 0 1 1 1 0 fzo-like conserved region PBC PF03792.13 EFA83115.1 - 0.18 11.5 5.2 0.094 12.5 1.3 2.6 2 1 0 2 2 2 0 PBC domain YMF19 PF02326.15 EFA83116.1 - 0.39 11.5 3.7 23 5.8 0.2 2.7 2 0 0 2 2 2 0 Plant ATP synthase F0 AtuA PF07287.11 EFA83117.1 - 3.9e-81 272.5 0.0 5e-81 272.1 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Metallophos PF00149.28 EFA83118.1 - 2.1e-36 126.4 0.1 3.1e-36 125.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA83118.1 - 0.081 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain RabGAP-TBC PF00566.18 EFA83119.1 - 4.6e-29 101.6 1.3 1.2e-28 100.3 1.3 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF962 PF06127.11 EFA83119.1 - 0.031 14.4 0.2 0.11 12.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF962) ANAPC4_WD40 PF12894.7 EFA83120.1 - 8.5e-10 38.8 0.2 0.12 12.7 0.0 4.4 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA83120.1 - 1.8e-09 38.0 7.2 0.056 14.3 0.1 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat GRASP55_65 PF04495.14 EFA83120.1 - 0.024 14.9 0.1 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain Dicty_REP PF05086.12 EFA83120.1 - 0.035 12.1 17.1 0.055 11.5 17.1 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Macoilin PF09726.9 EFA83120.1 - 0.8 8.2 11.7 1 7.8 11.7 1.1 1 0 0 1 1 1 0 Macoilin family MAP65_ASE1 PF03999.12 EFA83120.1 - 1.3 7.7 18.2 1.7 7.2 18.2 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Hamartin PF04388.12 EFA83120.1 - 2.3 6.8 15.2 3.1 6.4 15.2 1.1 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 EFA83120.1 - 2.6 7.2 23.2 3.9 6.6 23.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4551 PF15087.6 EFA83120.1 - 5.1 5.8 11.0 7 5.4 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ank_4 PF13637.6 EFA83121.1 - 1.7e-24 85.8 14.7 0.001 19.6 0.1 9.6 8 2 3 11 11 11 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83121.1 - 3.8e-24 85.1 7.0 1.8e-05 25.2 0.1 5.7 1 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA83121.1 - 6.2e-17 60.0 6.4 19 6.3 0.0 13.2 10 3 4 14 14 14 3 Ankyrin repeat Ank_5 PF13857.6 EFA83121.1 - 4.9e-15 55.4 13.2 0.99 9.8 0.1 11.2 5 2 7 12 12 12 7 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA83121.1 - 0.00032 20.5 8.6 0.28 10.9 1.0 4.3 2 1 2 4 4 4 2 Multigene family 530 protein DUF3447 PF11929.8 EFA83121.1 - 0.0061 16.5 13.7 1.4 8.9 0.1 6.0 2 2 4 7 7 7 2 Domain of unknown function (DUF3447) Kelch_6 PF13964.6 EFA83122.1 - 1e-10 41.5 6.3 0.00048 20.3 0.1 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EFA83122.1 - 0.0041 17.1 6.1 3.2 7.9 0.0 4.9 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA83122.1 - 0.0055 16.6 0.7 4.8 7.3 0.2 3.6 3 0 0 3 3 3 1 Kelch motif zf-B_box PF00643.24 EFA83122.1 - 0.0082 16.3 11.8 0.023 14.8 11.8 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_5 PF13854.6 EFA83122.1 - 0.049 13.6 3.4 2.1 8.4 0.3 3.6 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 EFA83122.1 - 0.093 12.3 8.6 0.43 10.2 0.1 4.3 4 1 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 EFA83122.1 - 0.29 11.5 1.3 1.4e+02 3.0 0.0 4.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Promethin PF16015.5 EFA83123.1 - 0.78 9.7 5.9 2.1 8.3 5.9 1.8 1 0 0 1 1 1 0 Promethin PYNP_C PF07831.13 EFA83124.1 - 0.14 11.8 0.0 0.38 10.4 0.0 1.7 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain FNIP PF05725.12 EFA83125.1 - 1.9e-58 194.4 29.0 1.8e-16 60.0 1.2 9.6 6 3 4 10 10 10 8 FNIP Repeat LRR_5 PF13306.6 EFA83125.1 - 0.18 11.7 6.4 0.51 10.3 0.0 3.8 3 2 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) F-box-like PF12937.7 EFA83126.1 - 0.00032 20.5 0.2 0.00063 19.6 0.2 1.5 1 0 0 1 1 1 1 F-box-like DUF1986 PF09342.11 EFA83126.1 - 0.099 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) PP_kinase_C PF13090.6 EFA83127.1 - 5.3e-63 211.6 0.0 1.1e-62 210.5 0.0 1.6 1 0 0 1 1 1 1 Polyphosphate kinase C-terminal domain 2 PP_kinase PF02503.17 EFA83127.1 - 6.9e-63 211.9 1.6 1.4e-62 210.9 1.6 1.5 1 0 0 1 1 1 1 Polyphosphate kinase middle domain PP_kinase_C_1 PF17941.1 EFA83127.1 - 2.4e-59 199.6 0.4 1.6e-58 196.9 0.1 2.2 1 1 1 2 2 2 1 Polyphosphate kinase C-terminal domain 1 PP_kinase_N PF13089.6 EFA83127.1 - 8.7e-19 67.8 0.5 2.8e-18 66.2 0.5 2.0 1 0 0 1 1 1 1 Polyphosphate kinase N-terminal domain PLDc_2 PF13091.6 EFA83127.1 - 1e-07 31.9 0.0 0.0032 17.4 0.0 3.0 2 1 0 2 2 2 2 PLD-like domain DUF2053 PF09767.9 EFA83128.1 - 6.1e-45 153.2 3.4 1.2e-44 152.3 3.4 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) SF1-HH PF16275.5 EFA83129.1 - 5.9e-37 126.5 1.3 5.9e-37 126.5 1.3 3.2 3 1 0 3 3 3 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EFA83129.1 - 2.9e-10 39.8 0.1 6.8e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 KH domain Mob1_phocein PF03637.17 EFA83130.1 - 1.4e-73 246.5 0.0 1.7e-73 246.2 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family Mito_carr PF00153.27 EFA83131.1 - 1.1e-72 240.1 2.8 4.5e-26 90.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein FNIP PF05725.12 EFA83132.1 - 1.6e-39 133.8 44.6 1.8e-14 53.6 1.6 9.6 9 3 1 10 10 10 7 FNIP Repeat F-box-like PF12937.7 EFA83132.1 - 0.0019 18.1 0.4 0.0042 16.9 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA83132.1 - 0.019 14.5 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 F-box HCBP_related PF06594.11 EFA83132.1 - 0.74 9.8 7.1 0.11 12.5 1.2 2.6 3 0 0 3 3 3 0 Haemolysin-type calcium binding protein related domain LRR_1 PF00560.33 EFA83132.1 - 1.7 9.5 4.8 22 6.1 0.2 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat zinc_ribbon_6 PF14599.6 EFA83133.1 - 3e-21 75.2 1.6 3e-21 75.2 1.6 4.4 2 1 2 5 5 3 1 Zinc-ribbon zf-CHY PF05495.12 EFA83133.1 - 5.6e-19 68.4 22.7 5.6e-19 68.4 22.7 3.9 3 1 0 3 3 2 1 CHY zinc finger zf-RING_2 PF13639.6 EFA83133.1 - 1.1e-10 41.6 5.8 1.1e-10 41.6 5.8 5.6 4 2 1 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 EFA83133.1 - 3.8e-08 33.1 4.7 3.8e-08 33.1 4.7 6.1 2 1 3 5 5 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA83133.1 - 2e-07 30.7 4.4 2e-07 30.7 4.4 5.9 3 2 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA83133.1 - 2.1e-06 27.5 6.4 2.1e-06 27.5 6.4 5.3 5 4 0 5 5 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA83133.1 - 3.6e-06 26.9 1.5 3.6e-06 26.9 1.5 5.0 5 2 0 5 5 5 1 RING-type zinc-finger zf-RING_4 PF14570.6 EFA83133.1 - 7.6e-05 22.4 2.1 7.6e-05 22.4 2.1 5.1 2 1 3 5 5 2 1 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EFA83133.1 - 0.00025 20.7 1.4 0.00025 20.7 1.4 4.4 5 1 0 5 5 3 1 RING-like zinc finger Prok-RING_1 PF14446.6 EFA83133.1 - 0.013 15.4 0.2 0.013 15.4 0.2 6.7 7 3 2 9 9 7 0 Prokaryotic RING finger family 1 Prothymosin PF03247.14 EFA83133.1 - 0.93 10.0 28.8 1.5 9.3 28.8 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family PPP4R2 PF09184.11 EFA83133.1 - 4.7 6.7 19.2 7 6.1 19.2 1.2 1 0 0 1 1 1 0 PPP4R2 DrsE_2 PF13686.6 EFA83134.1 - 0.025 14.5 0.5 0.036 14.0 0.5 1.2 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family Androgen_recep PF02166.16 EFA83134.1 - 4.1 6.1 11.2 4.9 5.9 11.2 1.1 1 0 0 1 1 1 0 Androgen receptor SUIM_assoc PF16619.5 EFA83134.1 - 5.8 7.1 16.6 2.1 8.4 13.0 2.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Apolipoprotein PF01442.18 EFA83136.1 - 1.7e-25 90.0 42.8 6.6e-08 32.6 0.8 6.1 3 2 2 5 5 5 5 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EFA83136.1 - 1.2e-06 29.0 38.0 0.16 12.6 5.2 8.4 3 2 6 9 9 9 4 Bacterial protein of unknown function (DUF883) DUF1640 PF07798.11 EFA83136.1 - 0.00013 22.1 43.5 0.0049 16.9 4.0 6.5 3 2 2 5 5 5 4 Protein of unknown function (DUF1640) ApoLp-III PF07464.11 EFA83136.1 - 0.0003 20.9 58.8 0.13 12.4 2.2 7.1 3 3 4 7 7 7 6 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 EFA83136.1 - 0.0019 18.3 27.8 3.9 7.5 0.1 7.0 3 2 5 8 8 8 4 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 EFA83136.1 - 0.0065 17.0 75.2 0.66 10.5 5.8 10.0 5 3 1 6 6 4 4 YtxH-like protein ApoO PF09769.9 EFA83136.1 - 0.075 13.0 14.9 46 4.0 0.1 7.8 3 3 2 5 5 5 0 Apolipoprotein O Prominin PF05478.11 EFA83136.1 - 0.16 9.9 33.2 0.9 7.4 1.2 4.4 3 1 1 4 4 4 0 Prominin MbeD_MobD PF04899.12 EFA83136.1 - 2 8.6 5.4 2.2 8.4 1.2 3.2 3 0 0 3 3 2 0 MbeD/MobD like DUF2379 PF09543.10 EFA83136.1 - 2.2 8.5 5.8 2 8.6 2.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2379) Exonuc_VII_L PF02601.15 EFA83136.1 - 9.9 5.6 39.3 5 6.6 10.0 4.9 3 2 0 4 4 4 0 Exonuclease VII, large subunit Ras PF00071.22 EFA83137.1 - 2.2e-60 202.9 0.1 2.6e-60 202.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA83137.1 - 1.6e-19 70.2 0.0 2.4e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83137.1 - 1.2e-10 41.1 0.0 1.5e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA83137.1 - 1e-06 28.4 0.2 4e-06 26.5 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA83137.1 - 2.9e-05 24.0 0.0 0.052 13.5 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EFA83137.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EFA83137.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region zf-CCHC PF00098.23 EFA83138.1 - 0.00021 21.2 11.8 0.025 14.6 2.7 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EFA83138.1 - 0.0053 16.5 4.6 0.5 10.1 1.1 2.4 2 0 0 2 2 2 2 Zinc knuckle Mad3_BUB1_II PF08171.11 EFA83138.1 - 0.022 14.9 0.2 0.022 14.9 0.2 2.4 2 0 0 2 2 2 0 Mad3/BUB1 homology region 2 GHL6 PF14871.6 EFA83138.1 - 0.059 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Herp-Cyclin PF09241.10 EFA83138.1 - 0.094 13.4 0.8 0.31 11.7 0.2 2.3 2 0 0 2 2 2 0 Herpesviridae viral cyclin DUF3716 PF12511.8 EFA83138.1 - 0.17 11.9 6.7 0.36 10.9 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Gon7 PF08738.10 EFA83138.1 - 0.63 10.1 10.8 0.53 10.4 6.4 2.7 2 1 0 2 2 2 0 Gon7 family Menin PF05053.13 EFA83138.1 - 2.1 6.6 10.3 3.5 5.9 10.3 1.2 1 0 0 1 1 1 0 Menin zf-CCHC_2 PF13696.6 EFA83138.1 - 3.2 7.7 13.3 0.036 13.9 2.7 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 EFA83138.1 - 3.7 7.4 11.9 0.21 11.4 3.4 2.5 2 0 0 2 2 2 0 C2H2 zinc-finger CBM49 PF09478.10 EFA83139.1 - 7.1e-18 64.7 0.2 1e-17 64.2 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 SIR4_SID PF16991.5 EFA83140.1 - 7.1 6.7 14.2 8.8 6.4 13.9 1.3 1 1 0 1 1 1 0 Sir4 SID domain DUF740 PF05340.12 EFA83140.1 - 9.5 4.8 14.4 9.8 4.8 14.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) CDC45 PF02724.14 EFA83140.1 - 9.9 4.3 19.1 10 4.2 19.1 1.0 1 0 0 1 1 1 0 CDC45-like protein NADH_B2 PF14813.6 EFA83141.1 - 1.1e-05 25.1 3.1 1.3e-05 24.8 3.1 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Pkinase PF00069.25 EFA83142.1 - 1.3e-66 224.7 0.0 1.3e-66 224.7 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83142.1 - 1.6e-46 158.7 0.0 1.6e-46 158.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 EFA83142.1 - 9.1e-16 58.0 0.1 9.8e-15 54.7 0.1 3.0 1 0 0 1 1 1 1 P21-Rho-binding domain VPS9 PF02204.18 EFA83142.1 - 4.3e-15 55.8 0.3 1.5e-14 54.0 0.3 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Pkinase_fungal PF17667.1 EFA83142.1 - 0.00011 21.1 0.0 0.00011 21.1 0.0 4.3 4 1 0 4 4 4 1 Fungal protein kinase PH PF00169.29 EFA83142.1 - 0.0041 17.6 0.0 0.017 15.6 0.0 2.1 1 0 0 1 1 1 1 PH domain Kelch_6 PF13964.6 EFA83143.1 - 3.2e-15 55.8 0.8 1.1e-07 31.9 0.0 4.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFA83143.1 - 0.0048 16.4 0.5 0.18 11.5 0.0 3.0 3 1 0 3 3 3 1 Kelch motif zf-B_box PF00643.24 EFA83143.1 - 0.015 15.4 5.9 0.042 14.0 5.9 1.7 1 0 0 1 1 1 0 B-box zinc finger Kelch_5 PF13854.6 EFA83143.1 - 0.027 14.5 1.2 17 5.5 0.1 3.5 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA83143.1 - 0.086 12.9 4.7 7 6.7 0.2 4.3 4 1 0 4 4 4 0 Galactose oxidase, central domain ArfGap PF01412.18 EFA83143.1 - 0.18 11.9 6.7 0.041 14.0 2.1 2.3 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Kelch_2 PF07646.15 EFA83143.1 - 0.21 11.6 2.3 1.6 8.9 0.1 3.2 4 0 0 4 4 4 0 Kelch motif Inhibitor_I69 PF13734.6 EFA83143.1 - 0.29 11.6 5.1 0.17 12.3 0.5 2.8 3 0 0 3 3 3 0 Spi protease inhibitor Ribosomal_L18A PF01775.17 EFA83144.1 - 9e-50 167.8 2.1 1.2e-49 167.4 2.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Urb2 PF10441.9 EFA83145.1 - 2.6e-16 60.2 0.8 2.6e-16 60.2 0.8 5.2 6 2 0 6 6 6 2 Urb2/Npa2 family CSN8_PSD8_EIF3K PF10075.9 EFA83146.1 - 0.031 14.3 0.4 0.034 14.1 0.4 1.1 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family Acetyltransf_9 PF13527.7 EFA83147.1 - 0.00045 20.3 0.0 0.0045 17.1 0.0 2.4 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Flavodoxin_1 PF00258.25 EFA83147.1 - 0.0024 18.1 0.0 0.0036 17.5 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin CN_hydrolase PF00795.22 EFA83148.1 - 1.1e-41 142.9 0.0 1.6e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EFA83148.1 - 6.2e-26 91.0 0.0 1.2e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 NAD synthase EF-hand_1 PF00036.32 EFA83149.1 - 2e-12 45.7 0.4 2.1e-06 26.9 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFA83149.1 - 4.7e-12 46.2 0.1 1.4e-11 44.7 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair WWE PF02825.20 EFA83149.1 - 1.1e-11 45.1 0.9 4.4e-11 43.2 0.9 2.2 1 0 0 1 1 1 1 WWE domain EF-hand_6 PF13405.6 EFA83149.1 - 4.7e-10 38.6 0.1 4.3e-06 26.2 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFA83149.1 - 6e-09 35.6 0.0 4.4e-05 23.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair ubiquitin PF00240.23 EFA83149.1 - 8.3e-08 31.9 0.1 2.4e-07 30.4 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin family VWA_2 PF13519.6 EFA83149.1 - 6.2e-07 30.0 0.0 2e-06 28.4 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain EF-hand_5 PF13202.6 EFA83149.1 - 1.5e-06 27.4 0.1 3.1e-05 23.2 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 EFA83149.1 - 0.00033 20.9 0.0 0.00088 19.6 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain Rad60-SLD PF11976.8 EFA83149.1 - 0.00072 19.3 0.7 0.0063 16.3 0.2 2.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like YL1 PF05764.13 EFA83149.1 - 0.0033 17.6 10.2 0.0033 17.6 10.2 2.1 2 0 0 2 2 2 1 YL1 nuclear protein CDC45 PF02724.14 EFA83149.1 - 0.0071 14.7 7.1 0.012 14.0 7.1 1.2 1 0 0 1 1 1 1 CDC45-like protein VWA_3 PF13768.6 EFA83149.1 - 0.048 13.6 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain UN_NPL4 PF11543.8 EFA83149.1 - 0.084 13.4 1.4 5.5 7.5 0.1 2.9 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 EF-hand_14 PF17959.1 EFA83149.1 - 0.087 13.2 0.0 0.32 11.3 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain Spt5_N PF11942.8 EFA83149.1 - 0.092 13.7 10.8 0.26 12.3 10.8 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Presenilin PF01080.17 EFA83149.1 - 0.12 11.1 1.3 0.23 10.2 1.3 1.4 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 EFA83149.1 - 0.19 10.5 4.6 0.36 9.6 4.6 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CENP-B_dimeris PF09026.10 EFA83149.1 - 0.63 10.5 6.7 2 8.9 6.7 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4598 PF15370.6 EFA83149.1 - 1.1 9.7 8.3 2.9 8.4 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) PBP1_TM PF14812.6 EFA83149.1 - 2 8.8 6.1 6.2 7.3 6.1 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PTPRCAP PF15713.5 EFA83149.1 - 6 7.1 11.5 17 5.7 11.5 1.7 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated ATP-synt_ab PF00006.25 EFA83150.1 - 2.9e-68 229.7 0.0 4.2e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFA83150.1 - 1.8e-10 41.2 0.3 3.3e-10 40.3 0.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Rad10 PF03834.14 EFA83150.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Fmp27_SW PF10305.9 EFA83151.1 - 0.1 13.3 2.8 0.26 12.0 0.2 2.4 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain DNA_pol_B PF00136.21 EFA83152.1 - 3.5e-99 332.6 1.2 3.5e-99 332.6 1.2 2.6 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFA83152.1 - 5.3e-19 68.5 1.4 3.5e-12 46.1 0.4 2.8 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain Pkinase PF00069.25 EFA83153.1 - 1.3e-39 136.1 0.0 3.8e-38 131.4 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83153.1 - 2.8e-26 92.4 0.0 3.8e-24 85.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFA83153.1 - 2.4e-05 23.8 0.0 3.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EFA83153.1 - 0.0019 17.9 0.0 0.45 10.1 0.0 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 EFA83153.1 - 0.046 12.8 0.0 0.067 12.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EFA83153.1 - 0.19 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_membrane PF00664.23 EFA83154.1 - 1.4e-64 218.4 32.9 2.3e-30 106.2 16.4 3.6 2 1 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EFA83154.1 - 1.1e-51 175.0 0.2 1.7e-27 96.6 0.0 2.9 2 0 0 2 2 2 2 ABC transporter His_Phos_2 PF00328.22 EFA83154.1 - 2.3e-21 76.6 0.1 4e-21 75.8 0.1 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MTABC_N PF16185.5 EFA83154.1 - 9.5e-09 35.1 10.8 2.1e-08 34.0 7.6 2.7 2 0 0 2 2 2 1 Mitochondrial ABC-transporter N-terminal five TM region SMC_N PF02463.19 EFA83154.1 - 2.5e-07 30.4 6.0 0.044 13.2 0.2 4.4 2 2 1 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFA83154.1 - 6.3e-07 29.5 0.1 0.039 14.0 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA83154.1 - 1.8e-05 24.7 0.2 0.012 15.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFA83154.1 - 3.9e-05 23.3 0.3 0.55 10.0 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA83154.1 - 0.00011 22.7 0.5 0.13 12.7 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_7 PF12775.7 EFA83154.1 - 0.0023 17.5 0.1 0.31 10.5 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region CDC45 PF02724.14 EFA83154.1 - 0.0028 16.1 1.5 0.0044 15.4 1.5 1.2 1 0 0 1 1 1 1 CDC45-like protein Zeta_toxin PF06414.12 EFA83154.1 - 0.0094 15.2 0.2 4.1 6.6 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin Roc PF08477.13 EFA83154.1 - 0.031 14.5 0.1 15 5.9 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFA83154.1 - 0.046 13.3 1.2 1.9 8.0 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EFA83154.1 - 0.063 13.0 0.1 2.6 7.7 0.0 3.2 2 1 1 3 3 3 0 AAA domain AAA_33 PF13671.6 EFA83154.1 - 0.077 13.1 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFA83154.1 - 0.088 13.1 5.1 7.3 6.9 0.1 3.4 3 1 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EFA83154.1 - 0.11 12.6 13.6 4.7 7.2 9.3 3.4 2 1 0 2 2 2 0 Dynamin family AAA_12 PF13087.6 EFA83154.1 - 0.11 12.1 1.5 1.9 8.1 0.6 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFA83154.1 - 0.15 12.6 2.2 6.7 7.3 0.0 3.6 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 EFA83154.1 - 0.15 11.9 0.3 3.2 7.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain MeaB PF03308.16 EFA83154.1 - 0.17 10.9 0.3 17 4.3 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB COX7a PF02238.15 EFA83154.1 - 0.32 11.4 2.3 2.5 8.6 2.3 2.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII DUF87 PF01935.17 EFA83154.1 - 1.1 9.3 12.3 1.3 9.0 0.1 3.2 3 0 0 3 3 2 0 Helicase HerA, central domain Macoilin PF09726.9 EFA83154.1 - 4.1 5.8 13.6 6.3 5.2 13.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF295 PF03478.18 EFA83155.1 - 1.7 8.3 4.1 3.1 7.4 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF295) NAP PF00956.18 EFA83157.1 - 3e-12 46.3 23.9 1.4e-09 37.5 10.9 2.7 1 1 2 3 3 3 2 Nucleosome assembly protein (NAP) PBP1_TM PF14812.6 EFA83157.1 - 0.55 10.6 10.2 1.3 9.5 5.5 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EXS PF03124.14 EFA83158.1 - 1.3e-66 225.2 16.3 5.8e-58 196.8 11.9 2.2 1 1 1 2 2 2 2 EXS family SPX PF03105.19 EFA83158.1 - 5.7e-33 115.4 21.4 4.1e-19 69.8 15.7 2.3 1 1 1 2 2 2 2 SPX domain TFIIA PF03153.13 EFA83158.1 - 0.0011 19.1 26.0 0.0018 18.4 26.0 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2464 PF10240.9 EFA83158.1 - 0.45 10.0 7.6 0.87 9.1 7.6 1.4 1 0 0 1 1 1 0 Multivesicular body subunit 12 PAT1 PF09770.9 EFA83158.1 - 0.73 8.0 24.7 1.1 7.5 24.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 EFA83158.1 - 3.8 7.5 6.3 7.3 6.6 6.3 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM76 PF16046.5 EFA83158.1 - 9 5.5 13.3 17 4.6 13.3 1.4 1 0 0 1 1 1 0 FAM76 protein Nop52 PF05997.12 EFA83159.1 - 1.5e-51 175.3 2.4 1.5e-51 175.3 2.4 1.8 2 0 0 2 2 2 1 Nucleolar protein,Nop52 TAN PF11640.8 EFA83159.1 - 0.047 13.8 0.6 0.13 12.4 0.0 2.1 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Nop14 PF04147.12 EFA83159.1 - 0.64 8.2 41.5 1.3 7.1 41.5 1.5 1 0 0 1 1 1 0 Nop14-like family FAM163 PF15069.6 EFA83159.1 - 5.6 7.4 7.8 16 5.9 7.8 1.8 1 0 0 1 1 1 0 FAM163 family zf-B_box PF00643.24 EFA83160.1 - 0.00081 19.5 10.5 0.0016 18.6 10.5 1.5 1 0 0 1 1 1 1 B-box zinc finger Diphtheria_C PF02763.14 EFA83160.1 - 5 6.7 6.9 1.8 8.2 0.5 2.7 3 0 0 3 3 3 0 Diphtheria toxin, C domain Chlam_PMP PF02415.17 EFA83161.1 - 0.033 14.7 82.3 0.039 14.4 0.8 11.5 13 0 0 13 13 13 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat CAF1C_H4-bd PF12265.8 EFA83162.1 - 3.3e-20 72.1 0.2 3.6e-19 68.8 0.1 2.6 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFA83162.1 - 1.7e-14 54.0 12.9 8.6e-06 26.4 0.1 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83162.1 - 4.8e-07 30.0 1.0 0.0032 17.7 0.2 3.6 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Dynactin_p62 PF05502.13 EFA83163.1 - 1.2e-32 113.3 38.0 1.4e-32 113.2 33.9 3.1 2 1 0 2 2 2 1 Dynactin p62 family Forkhead_N PF08430.12 EFA83163.1 - 1.9 9.1 14.4 0.35 11.5 10.6 1.7 2 0 0 2 2 2 0 Forkhead N-terminal region IMUP PF15761.5 EFA83163.1 - 2.4 8.9 10.9 7.6 7.3 10.9 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein Fe-S_biosyn PF01521.20 EFA83164.1 - 4.8e-18 65.4 0.1 6.3e-18 65.0 0.1 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Kelch_6 PF13964.6 EFA83165.1 - 8.2e-09 35.4 0.7 0.00065 19.9 0.0 5.1 5 1 0 5 5 5 1 Kelch motif zf-B_box PF00643.24 EFA83165.1 - 0.00042 20.4 11.4 0.001 19.2 11.4 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA83165.1 - 0.0014 18.9 0.0 0.018 15.4 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA83165.1 - 0.031 14.2 0.9 0.1 12.6 0.2 2.2 2 0 0 2 2 2 0 Kelch motif Bin3 PF06859.12 EFA83165.1 - 0.93 10.2 3.6 0.54 10.9 0.2 2.3 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) Secretin_N_2 PF07655.13 EFA83165.1 - 1.2 9.7 20.1 0.45 11.1 16.2 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Orf78 PF06024.12 EFA83165.1 - 9 6.7 8.9 25 5.2 8.9 1.7 1 0 0 1 1 1 0 Orf78 (ac78) Kelch_6 PF13964.6 EFA83166.1 - 9.2e-07 28.9 3.9 0.0011 19.1 0.0 5.1 6 1 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 EFA83166.1 - 0.0072 15.9 4.1 0.029 14.0 0.0 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 EFA83166.1 - 0.12 12.7 0.3 1.3 9.4 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA83166.1 - 1.2 9.3 16.7 0.17 12.0 12.4 1.8 2 0 0 2 2 2 0 B-box zinc finger Kelch_4 PF13418.6 EFA83166.1 - 2.1 8.4 4.7 4.2 7.5 0.1 3.2 3 1 0 3 3 3 0 Galactose oxidase, central domain PTPA PF03095.15 EFA83167.1 - 3.7e-20 72.6 0.0 5.3e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Ras PF00071.22 EFA83169.1 - 2.8e-57 192.8 0.0 3.3e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA83169.1 - 1.9e-24 86.2 0.0 2.8e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83169.1 - 9.7e-09 34.9 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA83169.1 - 0.00028 20.5 0.0 0.00072 19.2 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Es2 PF09751.9 EFA83171.1 - 1.1e-67 229.7 32.3 2.9e-41 142.6 11.0 3.0 2 1 1 3 3 3 2 Nuclear protein Es2 Kelch_6 PF13964.6 EFA83173.1 - 3.8e-07 30.2 0.2 8.9e-05 22.6 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 EFA83173.1 - 0.00039 19.9 0.3 0.054 13.1 0.0 3.2 3 0 0 3 3 3 1 Kelch motif EF-hand_10 PF14788.6 EFA83173.1 - 0.077 12.9 0.5 0.25 11.2 0.5 1.9 1 0 0 1 1 1 0 EF hand zf-B_box PF00643.24 EFA83173.1 - 0.11 12.7 13.2 0.22 11.7 13.2 1.5 1 0 0 1 1 1 0 B-box zinc finger Syntaxin-6_N PF09177.11 EFA83173.1 - 1.4 9.5 6.4 1 9.9 3.4 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4637 PF15470.6 EFA83173.1 - 2.2 8.0 8.2 0.18 11.5 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) zf-Sec23_Sec24 PF04810.15 EFA83173.1 - 2.8 8.1 7.3 2.9 8.0 5.5 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DEAD PF00270.29 EFA83174.1 - 1.4e-43 148.7 0.2 4.8e-43 147.0 0.2 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 EFA83174.1 - 6.9e-15 55.0 0.1 1.9e-14 53.6 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) AAA_22 PF13401.6 EFA83174.1 - 0.018 15.3 0.1 0.64 10.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 EFA83174.1 - 0.021 14.4 0.0 0.021 14.4 0.0 3.2 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain RhoGAP PF00620.27 EFA83175.1 - 5.8e-37 126.9 1.3 1.4e-36 125.6 0.0 2.2 2 1 0 2 2 2 1 RhoGAP domain C2 PF00168.30 EFA83175.1 - 4.5e-21 75.1 0.0 8.4e-20 71.0 0.0 2.7 3 0 0 3 3 3 1 C2 domain PH PF00169.29 EFA83175.1 - 6.2e-11 42.7 0.5 6.2e-11 42.7 0.5 2.3 3 0 0 3 3 3 1 PH domain PH_3 PF14593.6 EFA83175.1 - 1.7e-08 34.5 1.8 1.8e-08 34.4 0.2 1.9 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EFA83175.1 - 0.003 17.9 0.0 0.014 15.7 0.0 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain Nod1 PF17114.5 EFA83175.1 - 0.032 14.4 0.8 0.092 12.9 0.1 2.0 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 PH_2 PF08458.10 EFA83175.1 - 0.041 14.2 0.2 0.13 12.6 0.2 1.9 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Peptidase_C1 PF00112.23 EFA83177.1 - 3.3e-48 164.7 1.0 4.3e-48 164.3 1.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFA83177.1 - 0.093 11.5 0.5 0.36 9.5 0.1 1.9 2 0 0 2 2 2 0 Peptidase C1-like family hEGF PF12661.7 EFA83177.1 - 0.33 11.7 6.8 2.2 9.0 1.9 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.13 EFA83177.1 - 4.6 7.7 10.6 5.3 7.5 1.5 2.5 2 0 0 2 2 2 0 EGF-like domain DUF5355 PF17306.2 EFA83178.1 - 0.062 12.3 0.7 0.07 12.2 0.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5355) Pheromone PF08015.11 EFA83179.1 - 7.8 7.6 12.9 6.3 7.9 3.8 2.8 2 1 0 2 2 2 0 Fungal mating-type pheromone PI3K_1B_p101 PF10486.9 EFA83180.1 - 6.2e-06 24.3 0.6 6.2e-06 24.3 0.6 3.7 2 2 1 3 3 3 2 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Hemerythrin PF01814.23 EFA83182.1 - 2e-11 44.6 2.6 4e-11 43.6 2.6 1.5 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Bromodomain PF00439.25 EFA83182.1 - 1.2e-07 31.6 4.2 2.9e-07 30.4 2.9 2.3 2 0 0 2 2 2 1 Bromodomain ADK PF00406.22 EFA83182.1 - 1.6e-07 31.6 0.4 8.8e-07 29.1 0.4 2.3 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFA83182.1 - 7.8e-07 29.6 0.3 1.2e-05 25.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA83182.1 - 0.07 13.7 2.6 0.11 13.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFA83182.1 - 0.69 10.4 0.0 0.69 10.4 0.0 3.4 4 0 0 4 4 4 0 ABC transporter Mod_r PF07200.13 EFA83184.1 - 1.7e-25 89.8 13.0 3.2e-25 88.9 13.0 1.5 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Macoilin PF09726.9 EFA83184.1 - 2e-05 23.4 15.1 2.6e-05 23.0 15.1 1.1 1 0 0 1 1 1 1 Macoilin family KxDL PF10241.9 EFA83184.1 - 4.1e-05 23.8 6.1 0.00046 20.4 1.8 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein T3SSipB PF16535.5 EFA83184.1 - 0.014 15.9 1.7 0.041 14.4 1.8 1.6 1 1 0 1 1 1 0 Type III cell invasion protein SipB Cluap1 PF10234.9 EFA83184.1 - 0.084 12.3 5.4 0.15 11.4 5.4 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 SARAF PF06682.12 EFA83184.1 - 0.59 9.7 8.7 1.1 8.9 8.7 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Menin PF05053.13 EFA83184.1 - 0.61 8.4 6.7 0.95 7.7 6.7 1.3 1 0 0 1 1 1 0 Menin TMPIT PF07851.13 EFA83184.1 - 1.7 7.8 3.6 3.2 6.9 3.6 1.4 1 0 0 1 1 1 0 TMPIT-like protein Tmemb_55A PF09788.9 EFA83184.1 - 5.4 6.0 5.0 9.7 5.2 5.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 55A APG6_N PF17675.1 EFA83184.1 - 5.4 7.5 12.4 1.9 9.0 9.0 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Gag_p12 PF01141.18 EFA83184.1 - 7.5 7.0 10.6 26 5.2 5.8 3.0 2 1 1 3 3 3 0 Gag polyprotein, inner coat protein p12 DUF4238 PF14022.6 EFA83185.1 - 0.043 13.3 0.1 0.046 13.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) WD40 PF00400.32 EFA83186.1 - 8.6e-38 127.7 17.5 3.3e-09 37.2 0.4 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83186.1 - 1.2e-13 51.1 0.2 8.9e-05 22.7 0.1 4.7 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA83186.1 - 2.7e-05 23.1 1.6 0.04 12.6 0.4 3.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFA83186.1 - 0.00018 20.6 0.2 0.18 10.7 0.0 3.7 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EFA83186.1 - 0.033 14.7 2.9 9.5 6.9 0.8 4.1 4 1 0 4 4 4 0 PQQ-like domain DUF1513 PF07433.11 EFA83186.1 - 0.034 13.2 0.0 0.76 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Glyoxal_oxid_N PF07250.11 EFA83186.1 - 0.06 12.5 0.1 0.15 11.2 0.1 1.6 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus VanY PF02557.17 EFA83187.1 - 0.029 14.2 0.1 0.052 13.3 0.1 1.5 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase IL11 PF07400.11 EFA83187.1 - 0.038 13.6 0.0 0.077 12.6 0.0 1.5 1 0 0 1 1 1 0 Interleukin 11 RT_RNaseH_2 PF17919.1 EFA83190.1 - 0.00015 21.8 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA83190.1 - 0.0078 16.5 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase CENP-B_dimeris PF09026.10 EFA83190.1 - 0.23 11.9 4.6 0.39 11.1 4.6 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Integrase_H2C2 PF17921.1 EFA83192.1 - 7.7e-12 45.1 1.2 1.9e-11 43.9 1.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EFA83192.1 - 8.5e-12 45.3 0.1 2.3e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain DUF2787 PF10980.8 EFA83192.1 - 0.003 17.8 0.2 0.0099 16.1 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2787) MLVIN_C PF18697.1 EFA83192.1 - 0.039 14.0 0.0 0.19 11.8 0.0 2.3 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF308 PF03729.13 EFA83195.1 - 0.00017 21.8 5.3 0.00017 21.8 5.3 2.1 1 1 1 2 2 2 1 Short repeat of unknown function (DUF308) DUF2464 PF10240.9 EFA83195.1 - 0.1 12.2 1.2 0.15 11.6 1.2 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF4400 PF14348.6 EFA83195.1 - 0.39 10.2 5.2 0.19 11.2 2.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4400) DUF3040 PF11239.8 EFA83195.1 - 0.67 10.3 3.7 7 7.0 3.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) DUF3671 PF12420.8 EFA83195.1 - 0.99 9.5 4.7 16 5.6 4.7 2.2 1 1 0 1 1 1 0 Protein of unknown function TssN PF17555.2 EFA83195.1 - 1.7 7.9 8.8 3 7.2 8.8 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF202 PF02656.15 EFA83195.1 - 2.1 8.9 6.9 0.84 10.1 3.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF2417 PF10329.9 EFA83195.1 - 4.8 6.5 8.0 0.81 9.1 2.8 2.1 1 1 1 2 2 2 0 Region of unknown function (DUF2417) DHHC PF01529.20 EFA83195.1 - 9.3 6.4 12.2 5.6 7.1 3.9 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase Tetraspanin PF00335.20 EFA83195.1 - 9.8 5.8 17.1 26 4.4 17.1 1.8 1 1 0 1 1 1 0 Tetraspanin family SK_channel PF03530.14 EFA83196.1 - 0.0053 16.7 1.6 0.0053 16.7 1.6 2.6 4 0 0 4 4 4 1 Calcium-activated SK potassium channel Pox_A14 PF05767.12 EFA83196.1 - 0.033 14.4 1.7 0.13 12.4 0.9 2.5 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 FSH1 PF03959.13 EFA83197.1 - 5.3e-49 166.8 0.6 2.6e-48 164.5 0.6 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Rotavirus_VP1 PF12289.8 EFA83197.1 - 0.036 13.1 0.0 0.052 12.6 0.0 1.1 1 0 0 1 1 1 0 Rotavirus VP1 C-terminal domain Esterase_phd PF10503.9 EFA83197.1 - 0.18 11.3 0.0 0.26 10.7 0.0 1.6 1 1 0 1 1 1 0 Esterase PHB depolymerase FAD_binding_4 PF01565.23 EFA83198.1 - 4.1e-25 88.1 0.5 6.4e-25 87.5 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFA83198.1 - 1e-12 47.9 2.7 2.5e-12 46.7 2.7 1.7 1 0 0 1 1 1 1 Berberine and berberine like IBR PF01485.21 EFA83199.1 - 9.2e-18 64.2 35.8 6.3e-12 45.5 4.6 3.7 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFA83199.1 - 0.00041 20.6 3.3 0.00041 20.6 3.3 3.9 3 2 1 4 4 4 1 Ring finger domain Imm70 PF15601.6 EFA83199.1 - 0.0035 16.9 0.7 0.011 15.3 0.7 1.8 1 0 0 1 1 1 1 Immunity protein 70 zf-C3HC4 PF00097.25 EFA83199.1 - 0.0063 16.4 3.1 0.0063 16.4 3.1 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA83199.1 - 0.014 15.3 2.7 0.014 15.3 2.7 4.4 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA83199.1 - 0.025 14.3 2.0 0.025 14.3 2.0 2.9 2 0 0 2 2 2 0 RING-like zinc finger Mago-bind PF09282.10 EFA83200.1 - 4.6e-15 55.2 0.3 1e-14 54.1 0.3 1.6 1 0 0 1 1 1 1 Mago binding DZR PF12773.7 EFA83201.1 - 2.6e-05 24.1 2.0 4.5e-05 23.4 2.0 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EFA83201.1 - 2.7e-05 23.7 2.6 5.3e-05 22.8 2.6 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 EFA83201.1 - 0.0016 17.8 2.8 0.0027 17.0 2.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EFA83201.1 - 0.0092 16.7 0.6 0.0092 16.7 0.6 2.0 2 0 0 2 2 2 1 zinc-ribbon family Nudix_N_2 PF14803.6 EFA83201.1 - 0.016 15.2 4.0 0.57 10.1 0.2 2.5 2 0 0 2 2 2 0 Nudix N-terminal Apc15p PF05841.11 EFA83201.1 - 0.02 15.7 2.5 0.02 15.7 2.5 2.2 2 0 0 2 2 2 0 Apc15p protein EIIBC-GUT_N PF03612.14 EFA83201.1 - 0.028 14.1 3.0 0.028 14.1 3.0 1.9 1 1 1 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 EFA83201.1 - 2.5 6.7 8.0 3.1 6.5 8.0 1.1 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 EFA83201.1 - 6.2 6.2 11.8 9.3 5.6 11.8 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF755 PF05501.11 EFA83201.1 - 8.7 6.6 30.5 0.44 10.8 6.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Lipocalin_4 PF13648.6 EFA83202.1 - 0.21 12.6 1.1 0.58 11.1 0.0 2.2 2 0 0 2 2 2 0 Lipocalin-like domain FH2 PF02181.23 EFA83204.1 - 1.5e-73 248.0 2.6 1.5e-73 248.0 2.6 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFA83204.1 - 3.3e-32 111.7 5.7 3.3e-32 111.7 5.7 2.1 1 1 1 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EFA83204.1 - 0.0001 21.9 1.0 0.0001 21.9 1.0 2.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain RB_A PF01858.17 EFA83206.1 - 1.4e-27 96.8 10.1 4.7e-26 91.8 0.4 3.9 3 1 1 4 4 4 2 Retinoblastoma-associated protein A domain RB_B PF01857.20 EFA83206.1 - 8.1e-15 55.0 1.6 8.1e-15 55.0 1.6 3.2 3 1 0 3 3 3 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 EFA83206.1 - 1.4e-11 44.1 0.5 1.4e-11 44.1 0.5 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF3452) DUF366 PF04017.12 EFA83206.1 - 0.074 12.5 4.5 0.056 12.9 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF366) Wx5_PLAF3D7 PF09688.10 EFA83206.1 - 7 6.6 15.1 0.41 10.7 8.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) Antimicrobial18 PF08130.11 EFA83207.1 - 0.14 12.3 1.8 0.33 11.1 1.8 1.7 1 1 0 1 1 1 0 Type A lantibiotic family SR-25 PF10500.9 EFA83208.1 - 1.7 8.2 12.4 1.6 8.3 12.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 EFA83208.1 - 2.4 6.5 5.3 2.1 6.7 5.3 1.0 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF5009 PF16401.5 EFA83209.1 - 3e-08 33.5 1.8 1.1e-07 31.7 0.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5009) DUF1624 PF07786.12 EFA83209.1 - 0.0038 16.8 4.7 0.0038 16.8 4.7 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1624) DUF3439 PF11921.8 EFA83209.1 - 1.8 8.5 14.4 0.75 9.8 2.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Mob1_phocein PF03637.17 EFA83210.1 - 5.3e-82 273.9 0.1 6.4e-82 273.6 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family WD40 PF00400.32 EFA83211.1 - 2.1e-11 44.1 9.8 0.00028 21.6 0.5 5.1 4 1 0 4 4 4 3 WD domain, G-beta repeat WD40_like PF17005.5 EFA83211.1 - 3.6e-06 26.5 4.4 1.4e-05 24.6 4.4 2.0 1 1 0 1 1 1 1 WD40-like domain Det1 PF09737.9 EFA83211.1 - 0.16 11.0 3.1 0.092 11.8 0.8 1.7 2 0 0 2 2 2 0 De-etiolated protein 1 Det1 zf-C4H2 PF10146.9 EFA83212.1 - 6e-10 39.8 15.0 6e-10 39.8 15.0 2.0 2 0 0 2 2 2 1 Zinc finger-containing protein AAA PF00004.29 EFA83212.1 - 0.17 12.3 2.1 0.26 11.7 1.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PP2C_C PF07830.13 EFA83212.1 - 7.4 7.1 8.7 0.65 10.5 0.4 3.0 3 1 0 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain Ribosomal_S17 PF00366.20 EFA83213.1 - 2.1e-18 66.2 4.8 3.7e-18 65.4 4.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 TMEM51 PF15345.6 EFA83214.1 - 0.011 15.6 10.3 0.011 15.6 10.3 3.9 2 2 2 4 4 4 0 Transmembrane protein 51 Enolase_N PF03952.16 EFA83214.1 - 0.019 15.1 0.6 0.058 13.6 0.4 2.0 2 0 0 2 2 2 0 Enolase, N-terminal domain ERM PF00769.19 EFA83214.1 - 1.1 9.0 33.9 0.04 13.7 26.1 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Metallophos PF00149.28 EFA83215.1 - 4.1e-19 69.9 8.7 1.3e-18 68.3 8.7 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFA83215.1 - 2.1e-17 63.4 1.9 2.1e-17 63.4 1.9 2.3 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFA83215.1 - 1.7e-16 60.8 1.0 5.1e-16 59.3 0.2 2.3 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C DUF4756 PF15948.5 EFA83215.1 - 0.21 11.4 0.0 2.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4756) Pkinase PF00069.25 EFA83217.1 - 9.6e-69 231.7 1.2 1.3e-68 231.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83217.1 - 3.4e-36 124.9 0.0 9.5e-36 123.4 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1768 PF08719.11 EFA83217.1 - 1.2e-31 110.1 0.0 1.2e-31 110.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1768) Ank_2 PF12796.7 EFA83217.1 - 1e-14 54.9 0.2 0.046 14.3 0.0 4.8 3 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83217.1 - 2.6e-12 47.0 5.8 0.00037 21.0 0.0 6.2 5 2 1 6 6 6 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83217.1 - 7.6e-10 38.9 0.3 0.025 14.9 0.0 6.0 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83217.1 - 4.3e-06 26.7 4.8 3.2 8.6 0.0 7.5 10 1 1 11 11 8 1 Ankyrin repeat APH PF01636.23 EFA83217.1 - 0.059 13.3 0.0 0.29 11.0 0.0 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family SOG2 PF10428.9 EFA83217.1 - 0.065 12.4 19.4 0.11 11.7 19.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 EFA83217.1 - 0.12 12.3 24.6 0.2 11.6 24.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IDEAL PF08858.10 EFA83217.1 - 0.49 10.2 0.0 0.49 10.2 0.0 2.7 3 0 0 3 3 3 0 IDEAL domain PAT1 PF09770.9 EFA83217.1 - 6.9 4.8 20.3 10 4.2 20.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RRM_1 PF00076.22 EFA83219.1 - 2.4e-18 65.7 0.1 4.5e-18 64.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EFA83219.1 - 0.0071 16.2 0.0 0.026 14.3 0.0 2.1 1 1 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RL PF17797.1 EFA83219.1 - 0.047 13.7 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 RL domain G10 PF01125.17 EFA83219.1 - 0.05 13.4 0.2 0.072 12.9 0.2 1.3 1 0 0 1 1 1 0 G10 protein Nup35_RRM_2 PF14605.6 EFA83219.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PRKG1_interact PF15898.5 EFA83219.1 - 0.65 10.9 8.0 1.2 10.1 8.0 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain PA26 PF04636.13 EFA83219.1 - 2.1 7.2 4.1 2.8 6.8 4.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RhoGAP PF00620.27 EFA83220.1 - 0.038 13.8 1.8 0.053 13.4 0.3 2.0 2 0 0 2 2 2 0 RhoGAP domain FTP PF07504.13 EFA83220.1 - 0.13 12.1 0.3 0.33 10.8 0.0 1.9 2 0 0 2 2 2 0 Fungalysin/Thermolysin Propeptide Motif Macro PF01661.21 EFA83220.1 - 0.17 11.9 0.1 0.72 9.9 0.1 2.1 2 0 0 2 2 2 0 Macro domain Transferase PF02458.15 EFA83221.1 - 0.0002 20.1 0.0 0.00096 17.9 0.0 1.8 1 1 0 1 1 1 1 Transferase family CBM_14 PF01607.24 EFA83222.1 - 2.5e-08 34.0 3.3 2.5e-08 34.0 3.3 1.8 1 1 1 2 2 2 1 Chitin binding Peritrophin-A domain Epsilon_antitox PF08998.11 EFA83223.1 - 0.00099 19.3 0.1 0.0013 18.9 0.1 1.3 1 0 0 1 1 1 1 Bacterial epsilon antitoxin DUF3113 PF11310.8 EFA83223.1 - 0.067 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) Fmp27_SW PF10305.9 EFA83223.1 - 0.12 13.1 0.3 0.22 12.3 0.3 1.6 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Methyltransf_32 PF13679.6 EFA83224.1 - 1.8e-26 93.0 19.9 2.9e-15 56.6 7.8 3.1 2 1 1 3 3 3 2 Methyltransferase domain TFIIA PF03153.13 EFA83224.1 - 3e-05 24.2 24.1 4.1e-05 23.8 16.4 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Methyltransf_25 PF13649.6 EFA83224.1 - 6.4e-05 23.6 0.0 0.00035 21.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA83224.1 - 0.0011 18.8 5.7 0.0011 18.8 5.7 2.1 2 1 0 2 2 2 1 Methyltransferase domain CDC45 PF02724.14 EFA83224.1 - 0.0011 17.3 9.2 0.0011 17.3 9.2 1.7 2 0 0 2 2 2 1 CDC45-like protein Methyltransf_11 PF08241.12 EFA83224.1 - 0.0012 19.4 0.0 0.064 13.9 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain Spt20 PF12090.8 EFA83224.1 - 0.0051 16.4 27.9 0.0051 16.4 27.9 3.1 3 0 0 3 3 3 2 Spt20 family SpoIIP PF07454.11 EFA83224.1 - 0.008 15.7 10.4 0.008 15.7 10.4 2.4 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) PCMT PF01135.19 EFA83224.1 - 0.026 14.3 0.0 0.026 14.3 0.0 2.2 3 0 0 3 3 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EFA83224.1 - 0.053 13.1 0.0 0.64 9.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EFA83224.1 - 0.08 12.3 0.1 0.2 11.0 0.1 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RNA_pol_Rpc4 PF05132.14 EFA83224.1 - 0.21 12.0 13.3 0.04 14.4 8.2 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF913 PF06025.12 EFA83224.1 - 0.25 10.3 9.4 0.11 11.5 6.1 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) POX PF07526.11 EFA83224.1 - 0.31 11.6 16.6 0.14 12.8 10.9 2.8 3 0 0 3 3 3 0 Associated with HOX Pex14_N PF04695.13 EFA83224.1 - 0.31 11.7 25.3 0.033 14.9 7.5 2.7 3 0 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2052 PF09747.9 EFA83224.1 - 0.55 10.3 23.9 0.25 11.5 18.8 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Rtf2 PF04641.12 EFA83224.1 - 0.59 9.4 21.0 0.14 11.5 16.2 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 EFA83224.1 - 0.71 9.7 24.4 0.22 11.3 19.0 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 EFA83224.1 - 0.83 8.6 21.4 0.013 14.5 11.3 2.4 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF5308 PF17233.2 EFA83224.1 - 1 9.5 9.1 0.34 11.1 3.9 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5308) DUF4228 PF14009.6 EFA83224.1 - 1.1 9.7 10.4 1.1 9.6 7.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) AAA_11 PF13086.6 EFA83224.1 - 1.1 9.0 20.0 0.3 10.8 14.0 2.2 2 0 0 2 2 2 0 AAA domain BORG_CEP PF14957.6 EFA83224.1 - 1.3 10.2 13.0 0.61 11.2 7.8 2.8 3 0 0 3 3 2 0 Cdc42 effector GAGA_bind PF06217.12 EFA83224.1 - 1.5 9.1 17.5 0.44 10.8 11.9 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family DUF702 PF05142.12 EFA83224.1 - 1.8 9.1 16.1 0.79 10.2 10.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Mitofilin PF09731.9 EFA83224.1 - 2.5 6.9 29.5 0.18 10.6 22.3 2.3 3 0 0 3 3 3 0 Mitochondrial inner membrane protein Zip PF02535.22 EFA83224.1 - 3.5 6.8 8.1 1.1 8.3 4.8 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 EFA83224.1 - 4.9 5.7 17.0 11 4.6 14.0 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Exonuc_VII_L PF02601.15 EFA83224.1 - 6.7 6.2 18.6 11 5.5 14.7 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Z1 PF10593.9 EFA83224.1 - 6.8 6.1 13.7 2.5 7.5 9.4 2.3 2 0 0 2 2 2 0 Z1 domain MMR1 PF08505.10 EFA83224.1 - 6.8 6.9 28.8 0.65 10.2 16.9 2.8 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein PPL5 PF18168.1 EFA83224.1 - 8 5.7 13.0 2.2 7.5 8.2 2.1 2 0 0 2 2 2 0 Prim-pol family 5 DDRGK PF09756.9 EFA83224.1 - 9.2 5.8 34.9 0.4 10.2 25.9 2.2 2 0 0 2 2 2 0 DDRGK domain FAM176 PF14851.6 EFA83224.1 - 9.7 5.8 18.3 4 7.1 12.5 2.7 3 0 0 3 3 3 0 FAM176 family DAGK_acc PF00609.19 EFA83225.1 - 7.4e-50 169.4 0.0 1.5e-49 168.4 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EFA83225.1 - 1.7e-25 89.0 0.0 3.3e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain CRT-like PF08627.10 EFA83226.1 - 6.2e-155 515.2 24.4 7.1e-155 515.0 24.4 1.0 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 EFA83226.1 - 1.4e-09 37.9 7.9 1.4e-09 37.9 7.9 2.2 2 0 0 2 2 2 1 Solute carrier family 35 EamA PF00892.20 EFA83226.1 - 0.00095 19.4 9.4 0.00095 19.4 9.4 3.3 3 0 0 3 3 3 1 EamA-like transporter family HlyIII PF03006.20 EFA83226.1 - 3.9 7.1 13.7 0.28 10.9 7.3 2.0 2 0 0 2 2 2 0 Haemolysin-III related Autophagy_N PF03986.13 EFA83227.1 - 7.2e-42 142.6 1.7 7.2e-42 142.6 1.7 2.2 1 1 1 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EFA83227.1 - 9.6e-23 80.5 0.6 2.7e-22 79.1 0.6 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EFA83227.1 - 3.4e-13 48.9 3.9 3.4e-13 48.9 3.9 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein C-terminal PNISR PF15996.5 EFA83227.1 - 0.47 10.7 7.1 0.69 10.2 7.1 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Med13_C PF06333.12 EFA83227.1 - 3.9 6.7 7.5 5.4 6.2 7.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Macoilin PF09726.9 EFA83227.1 - 4.4 5.7 9.0 22 3.4 6.4 2.1 2 0 0 2 2 2 0 Macoilin family Menin PF05053.13 EFA83227.1 - 8.1 4.7 7.3 11 4.3 7.3 1.2 1 0 0 1 1 1 0 Menin DUF1908 PF08926.11 EFA83230.1 - 0.021 13.9 0.4 0.034 13.2 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) EF-hand_7 PF13499.6 EFA83231.1 - 1.3e-23 83.3 7.1 4.6e-14 52.6 1.0 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFA83231.1 - 2.5e-21 73.7 10.4 2.9e-06 26.7 0.0 4.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 EFA83231.1 - 2.9e-21 73.4 16.6 1.4e-06 27.5 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 EFA83231.1 - 3.1e-16 58.0 12.7 1.5e-06 27.4 1.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EFA83231.1 - 1.8e-13 50.1 15.9 9e-05 22.2 2.0 4.4 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA83231.1 - 4.5e-06 27.0 0.9 0.055 13.8 0.1 3.1 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_2 PF09068.11 EFA83231.1 - 0.024 14.8 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 EF hand Knl1_RWD_C PF18210.1 EFA83231.1 - 0.069 13.6 0.0 1.9 9.0 0.0 2.6 3 0 0 3 3 3 0 Knl1 RWD C-terminal domain Caleosin PF05042.13 EFA83231.1 - 0.11 12.4 2.6 21 5.0 0.9 3.7 1 1 1 2 2 2 0 Caleosin related protein EF-hand_4 PF12763.7 EFA83231.1 - 0.19 11.7 1.5 0.9 9.5 0.0 2.5 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand GCV_T PF01571.21 EFA83234.1 - 1.2e-05 24.8 0.0 4.6e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Aminomethyltransferase folate-binding domain IES5 PF17335.2 EFA83234.1 - 0.018 15.3 0.5 0.11 12.7 0.0 2.3 3 0 0 3 3 3 0 Ino80 complex subunit 5 Coiled PF05710.12 EFA83235.1 - 0.3 11.9 28.5 0.93 10.4 28.5 1.9 1 1 0 1 1 1 0 Coiled coil NUDIX PF00293.28 EFA83236.1 - 1.2e-09 38.3 0.0 1.8e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF3027 PF11228.8 EFA83236.1 - 0.093 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) RPN7 PF10602.9 EFA83237.1 - 2.9e-54 183.4 1.4 4e-54 182.9 1.4 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFA83237.1 - 3e-17 63.0 2.0 6.9e-17 61.9 0.1 2.4 2 0 0 2 2 2 1 PCI domain MRP-L46 PF11788.8 EFA83237.1 - 0.054 14.2 1.3 0.12 13.2 1.3 1.6 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 Epimerase PF01370.21 EFA83238.1 - 2.2e-55 187.8 0.0 3e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family SelK_SelG PF10961.8 EFA83238.1 - 1.5e-18 67.2 1.8 4e-18 65.8 1.8 1.7 1 0 0 1 1 1 1 Selenoprotein SelK_SelG GDP_Man_Dehyd PF16363.5 EFA83238.1 - 2.9e-13 49.9 3.8 3.9e-12 46.2 0.1 2.2 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFA83238.1 - 1.5e-06 27.5 1.1 3.5e-05 23.1 0.0 2.4 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFA83238.1 - 0.00022 20.4 2.6 0.0014 17.7 2.6 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFA83238.1 - 0.0003 20.0 0.0 0.0005 19.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EFA83238.1 - 0.042 13.0 1.2 0.37 9.9 0.0 2.2 1 1 0 2 2 2 0 Male sterility protein SPX PF03105.19 EFA83239.1 - 1.5e-17 64.6 11.2 2.9e-09 37.3 0.3 3.2 1 1 2 3 3 3 3 SPX domain EF-hand_1 PF00036.32 EFA83239.1 - 0.0054 16.2 0.0 1.7 8.4 0.0 2.9 3 0 0 3 3 3 2 EF hand DUF3907 PF13047.6 EFA83239.1 - 0.011 15.7 0.2 0.018 15.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) Nsp1_C PF05064.13 EFA83239.1 - 0.016 15.0 0.5 0.035 13.9 0.5 1.7 1 1 0 1 1 1 0 Nsp1-like C-terminal region PBP_like_2 PF12849.7 EFA83239.1 - 0.029 14.1 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 PBP superfamily domain DUF1874 PF08960.10 EFA83239.1 - 0.035 14.2 0.3 0.25 11.5 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1874) DUF4460 PF14687.6 EFA83240.1 - 6.1e-07 29.5 0.2 6.1e-07 29.5 0.2 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4460) TFIIA PF03153.13 EFA83240.1 - 7.5 6.4 53.9 0.49 10.3 43.7 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA PF00004.29 EFA83241.1 - 4.8e-45 153.2 0.1 1.7e-44 151.5 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA83241.1 - 9.3e-11 41.4 0.0 2.7e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFA83241.1 - 8.6e-09 35.5 0.1 2.4e-08 34.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_ID_OB PF16450.5 EFA83241.1 - 2.4e-08 33.8 0.1 7.6e-08 32.2 0.0 1.9 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EFA83241.1 - 1.4e-07 32.1 0.3 4.8e-05 23.8 0.0 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 EFA83241.1 - 2.2e-07 31.1 0.0 4.7e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFA83241.1 - 3.5e-05 24.1 2.0 0.0067 16.7 0.1 3.2 2 2 1 3 3 3 1 AAA domain RuvB_N PF05496.12 EFA83241.1 - 6.2e-05 22.8 0.0 0.00021 21.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EFA83241.1 - 8.3e-05 21.9 0.0 0.00015 21.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EFA83241.1 - 0.00033 21.2 0.0 0.001 19.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFA83241.1 - 0.00043 19.6 0.0 0.00074 18.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_28 PF13521.6 EFA83241.1 - 0.00071 19.8 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFA83241.1 - 0.0013 18.7 0.1 0.0094 16.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFA83241.1 - 0.0014 19.0 0.0 0.004 17.5 0.0 1.9 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 EFA83241.1 - 0.0015 18.3 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFA83241.1 - 0.0015 17.9 0.0 0.0035 16.8 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EFA83241.1 - 0.0016 18.2 0.1 0.12 12.1 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain TsaE PF02367.17 EFA83241.1 - 0.0041 17.1 0.0 0.0087 16.1 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFA83241.1 - 0.0053 16.3 0.1 0.041 13.4 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region NTPase_1 PF03266.15 EFA83241.1 - 0.008 16.1 0.0 0.096 12.6 0.0 2.4 2 0 0 2 2 2 1 NTPase AAA_33 PF13671.6 EFA83241.1 - 0.009 16.2 0.0 0.019 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFA83241.1 - 0.0091 15.6 0.6 0.035 13.7 0.1 1.9 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EFA83241.1 - 0.011 15.4 0.1 0.027 14.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFA83241.1 - 0.012 15.5 0.1 0.069 13.1 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_3 PF07726.11 EFA83241.1 - 0.013 15.3 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EFA83241.1 - 0.014 14.6 0.6 0.4 9.8 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain AAA_30 PF13604.6 EFA83241.1 - 0.017 14.9 0.1 0.036 13.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFA83241.1 - 0.02 14.3 0.1 1.4 8.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Parvo_NS1 PF01057.17 EFA83241.1 - 0.02 14.0 0.0 0.044 12.9 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 EFA83241.1 - 0.073 12.4 0.8 0.47 9.7 0.0 2.4 3 0 0 3 3 3 0 KaiC ABC_tran PF00005.27 EFA83241.1 - 0.13 12.7 0.2 0.78 10.2 0.0 2.4 2 2 0 2 2 2 0 ABC transporter DUF1640 PF07798.11 EFA83242.1 - 0.031 14.3 6.5 0.053 13.6 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF573 PF04504.14 EFA83242.1 - 0.27 11.9 5.9 6.2 7.5 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF573 Cyclin PF08613.11 EFA83243.1 - 1.2e-05 25.7 0.1 1.2e-05 25.7 0.1 1.6 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFA83243.1 - 0.0027 17.4 0.4 0.0027 17.4 0.4 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Snapin_Pallidin PF14712.6 EFA83244.1 - 0.0014 19.0 0.2 0.0014 19.0 0.2 2.3 2 0 0 2 2 2 1 Snapin/Pallidin DUF5542 PF17696.1 EFA83244.1 - 0.17 12.0 0.7 0.31 11.2 0.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5542) MRPL52 PF18699.1 EFA83244.1 - 0.72 10.1 9.0 8.4 6.7 4.7 2.4 2 0 0 2 2 2 0 Mitoribosomal protein mL52 Band_3_cyto PF07565.13 EFA83244.1 - 2.5 7.8 8.9 3.1 7.5 8.6 1.3 1 1 0 1 1 1 0 Band 3 cytoplasmic domain SMC_N PF02463.19 EFA83245.1 - 1.5e-18 67.1 20.6 1.7e-17 63.6 20.6 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFA83245.1 - 6.4e-15 56.2 20.6 6.4e-15 56.2 20.6 5.3 3 3 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EFA83245.1 - 9.2e-13 48.6 15.4 9.2e-13 48.6 15.4 3.6 3 1 0 3 3 3 1 AAA ATPase domain AAA_13 PF13166.6 EFA83245.1 - 0.00097 17.9 10.0 0.00097 17.9 10.0 5.0 4 3 0 4 4 4 2 AAA domain AAA_29 PF13555.6 EFA83245.1 - 0.001 18.8 0.0 0.0028 17.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFA83245.1 - 0.0044 16.9 0.2 0.38 10.5 0.4 3.1 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF1192 PF06698.11 EFA83245.1 - 0.08 13.0 0.3 0.08 13.0 0.3 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) SlyX PF04102.12 EFA83245.1 - 3.6 8.3 28.0 1.3 9.7 2.9 5.4 3 2 1 4 4 4 0 SlyX RsgA_GTPase PF03193.16 EFA83245.1 - 6.7 6.6 7.2 1.7 8.6 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase ZapB PF06005.12 EFA83246.1 - 0.00045 20.6 1.8 0.00045 20.6 1.8 1.6 2 0 0 2 2 2 1 Cell division protein ZapB Cnn_1N PF07989.11 EFA83246.1 - 0.00052 20.1 0.7 0.0008 19.5 0.7 1.4 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 DivIC PF04977.15 EFA83246.1 - 0.0023 17.6 1.3 0.0049 16.6 1.3 1.5 1 0 0 1 1 1 1 Septum formation initiator GAS PF13851.6 EFA83246.1 - 0.0024 17.2 0.4 0.0024 17.2 0.4 1.4 2 0 0 2 2 1 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EFA83246.1 - 0.0026 16.7 2.3 0.003 16.5 2.3 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 EFA83246.1 - 0.0027 17.9 2.5 0.0036 17.5 2.5 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF1640 PF07798.11 EFA83246.1 - 0.0029 17.7 0.2 0.004 17.2 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) TMF_DNA_bd PF12329.8 EFA83246.1 - 0.0051 16.8 3.4 0.011 15.7 3.4 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding HALZ PF02183.18 EFA83246.1 - 0.0053 17.0 0.4 0.011 16.0 0.4 1.5 1 1 0 1 1 1 1 Homeobox associated leucine zipper Csm1_N PF18504.1 EFA83246.1 - 0.0057 17.0 1.0 0.011 16.1 1.0 1.5 1 0 0 1 1 1 1 Csm1 N-terminal domain Prefoldin PF02996.17 EFA83246.1 - 0.0068 16.3 0.9 0.0068 16.3 0.9 1.8 2 1 0 2 2 2 1 Prefoldin subunit DivIVA PF05103.13 EFA83246.1 - 0.011 15.8 1.0 0.02 15.0 1.0 1.4 1 0 0 1 1 1 0 DivIVA protein Uso1_p115_C PF04871.13 EFA83246.1 - 0.014 15.7 1.3 0.026 14.9 1.3 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_1 PF00170.21 EFA83246.1 - 0.017 15.2 1.4 0.038 14.1 1.4 1.6 1 0 0 1 1 1 0 bZIP transcription factor DUF1664 PF07889.12 EFA83246.1 - 0.019 15.0 0.9 0.032 14.2 0.8 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HOOK PF05622.12 EFA83246.1 - 0.02 13.1 0.4 0.027 12.7 0.4 1.2 1 0 0 1 1 1 0 HOOK protein MbeD_MobD PF04899.12 EFA83246.1 - 0.02 15.0 0.3 0.034 14.3 0.3 1.3 1 0 0 1 1 1 0 MbeD/MobD like DUF4201 PF13870.6 EFA83246.1 - 0.021 14.6 0.6 0.035 13.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF5395 PF17373.2 EFA83246.1 - 0.033 14.8 0.0 0.05 14.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5395) Spc24 PF08286.11 EFA83246.1 - 0.034 14.4 0.2 0.054 13.7 0.2 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Snapin_Pallidin PF14712.6 EFA83246.1 - 0.035 14.5 0.4 0.062 13.7 0.4 1.4 1 0 0 1 1 1 0 Snapin/Pallidin SKA2 PF16740.5 EFA83246.1 - 0.036 13.8 0.7 0.054 13.3 0.7 1.3 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Ax_dynein_light PF10211.9 EFA83246.1 - 0.039 13.9 1.1 0.052 13.5 1.1 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain CdvA PF18822.1 EFA83246.1 - 0.044 13.6 3.5 0.067 13.0 1.3 2.0 1 1 1 2 2 2 0 CdvA-like coiled-coil domain FAD-SLDH PF12318.8 EFA83246.1 - 0.052 13.6 0.1 0.078 13.0 0.1 1.2 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase Caldesmon PF02029.15 EFA83246.1 - 0.069 11.9 0.2 0.085 11.6 0.2 1.1 1 0 0 1 1 1 0 Caldesmon Syntaxin-6_N PF09177.11 EFA83246.1 - 0.085 13.4 0.3 0.11 13.0 0.3 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal PRKG1_interact PF15898.5 EFA83246.1 - 0.089 13.7 3.8 0.093 13.6 1.1 1.9 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Matrilin_ccoil PF10393.9 EFA83246.1 - 0.1 12.5 0.7 0.18 11.7 0.7 1.5 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin BLOC1_2 PF10046.9 EFA83246.1 - 0.11 12.8 2.7 0.2 12.0 1.1 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 EFA83246.1 - 0.11 13.0 4.7 0.19 12.2 4.7 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region Occludin_ELL PF07303.13 EFA83246.1 - 0.11 13.2 0.4 1.6 9.5 0.2 2.1 2 0 0 2 2 2 0 Occludin homology domain Mto2_bdg PF12808.7 EFA83246.1 - 0.12 12.7 2.1 9.3 6.6 0.2 2.2 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region JIP_LZII PF16471.5 EFA83246.1 - 0.17 12.1 2.8 0.64 10.2 2.6 1.9 1 1 1 2 2 1 0 JNK-interacting protein leucine zipper II bZIP_2 PF07716.15 EFA83246.1 - 0.17 12.0 2.7 0.33 11.1 2.7 1.5 1 0 0 1 1 1 0 Basic region leucine zipper SlyX PF04102.12 EFA83246.1 - 0.21 12.2 1.1 0.39 11.4 1.1 1.4 1 0 0 1 1 1 0 SlyX FlaC_arch PF05377.11 EFA83246.1 - 0.21 12.0 2.2 0.66 10.4 0.4 2.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Swi5 PF07061.11 EFA83246.1 - 0.24 11.5 3.1 0.69 10.0 1.8 2.1 2 0 0 2 2 2 0 Swi5 CTP_transf_1 PF01148.20 EFA83247.1 - 2e-65 221.2 24.7 3e-65 220.6 24.7 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family DUF423 PF04241.15 EFA83247.1 - 7.7 6.8 8.3 1.1 9.5 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF423) Glyco_hydro_3 PF00933.21 EFA83248.1 - 1.3e-61 208.7 0.0 1.9e-61 208.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFA83248.1 - 1.7e-46 158.8 0.0 2.7e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFA83248.1 - 4.3e-11 42.8 0.0 7.6e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain TIG PF01833.24 EFA83249.1 - 1.6e-19 69.7 45.2 5.2e-05 23.2 2.1 9.0 8 0 0 8 8 8 7 IPT/TIG domain EGF_2 PF07974.13 EFA83249.1 - 6.9e-06 26.3 33.5 0.009 16.4 12.3 2.6 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EFA83249.1 - 0.014 16.0 24.4 0.67 10.7 7.6 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFA83249.1 - 0.027 14.8 24.7 0.45 10.9 9.3 2.6 2 0 0 2 2 2 0 EGF-like domain RuvA_N PF01330.21 EFA83249.1 - 0.062 13.4 0.4 80 3.4 0.0 4.8 4 0 0 4 4 4 0 RuvA N terminal domain PP1 PF07430.11 EFA83249.1 - 0.11 12.5 0.0 0.46 10.6 0.0 2.0 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain Lectin_C PF00059.21 EFA83249.1 - 0.14 12.9 10.5 0.031 15.0 0.9 3.4 3 0 0 3 3 3 0 Lectin C-type domain EGF_Tenascin PF18720.1 EFA83249.1 - 0.5 10.5 24.9 1 9.5 8.1 3.1 2 0 0 2 2 2 0 Tenascin EGF domain DUF3658 PF12395.8 EFA83250.1 - 0.007 16.3 1.8 0.028 14.3 1.8 2.1 1 0 0 1 1 1 1 Protein of unknown function GAS2 PF02187.17 EFA83250.1 - 0.0077 16.3 2.4 0.021 14.9 0.0 2.9 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain RNase_J_C PF17770.1 EFA83251.1 - 0.038 15.0 0.3 0.047 14.7 0.3 1.1 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain RET_CLD4 PF17813.1 EFA83251.1 - 0.038 14.3 0.1 0.044 14.1 0.1 1.1 1 0 0 1 1 1 0 RET Cadherin like domain 4 GLTP PF08718.11 EFA83251.1 - 0.089 13.1 0.2 0.092 13.0 0.2 1.0 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) E2F_TDP PF02319.20 EFA83252.1 - 5.2e-27 93.7 3.0 8.7e-14 51.3 0.2 2.6 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain Herpes_UL52 PF03121.15 EFA83252.1 - 0.0013 18.7 1.0 0.0041 17.0 1.0 1.9 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase DSPc PF00782.20 EFA83253.1 - 8.9e-26 90.3 0.0 8.9e-26 90.3 0.0 3.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Gelsolin PF00626.22 EFA83253.1 - 1.1e-09 38.0 2.2 0.0058 16.5 0.0 4.8 4 0 0 4 4 4 3 Gelsolin repeat CDKN3 PF05706.12 EFA83253.1 - 0.0015 18.2 0.2 0.0045 16.7 0.1 1.9 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) TFIIA PF03153.13 EFA83254.1 - 0.0098 15.9 4.8 0.0098 15.9 4.8 2.0 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 EFA83254.1 - 0.025 14.3 3.9 0.038 13.7 3.9 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3439 PF11921.8 EFA83254.1 - 0.093 12.7 1.2 0.19 11.7 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2722 PF10846.8 EFA83254.1 - 0.12 11.3 15.7 0.41 9.5 15.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4973 PF16343.5 EFA83254.1 - 0.13 12.4 0.2 0.13 12.4 0.2 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4973) TerB_C PF15615.6 EFA83254.1 - 0.58 10.4 4.7 1.4 9.2 1.9 2.3 2 1 0 2 2 2 0 TerB-C domain MctB PF11382.8 EFA83254.1 - 1.8 8.2 5.7 2.6 7.7 2.7 2.0 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB DUF2681 PF10883.8 EFA83255.1 - 0.00066 20.0 2.7 0.0018 18.6 2.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) Ofd1_CTDD PF10637.9 EFA83255.1 - 0.015 14.7 3.8 0.033 13.5 3.8 1.5 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term DUF4271 PF14093.6 EFA83255.1 - 0.034 14.1 0.1 0.034 14.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) Uteroglobin PF01099.17 EFA83255.1 - 8.2 6.8 9.5 1.8 9.0 0.1 3.2 2 1 0 2 2 2 0 Uteroglobin family Ge1_WD40 PF16529.5 EFA83256.1 - 3.5e-09 36.1 0.0 7.2e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein TAN PF11640.8 EFA83256.1 - 0.056 13.6 2.5 0.12 12.5 1.4 2.2 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair IP_trans PF02121.18 EFA83257.1 - 1.7e-113 378.2 0.1 2.1e-113 378.0 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Sec7 PF01369.20 EFA83259.1 - 4.2e-53 179.7 3.2 4.2e-53 179.7 3.2 3.0 2 1 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EFA83259.1 - 1.3e-30 106.3 0.9 1.3e-30 106.3 0.9 4.9 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EFA83259.1 - 1.3e-29 101.8 1.4 1.3e-29 101.8 1.4 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) DCB PF16213.5 EFA83259.1 - 4.8e-25 88.2 13.8 1.1e-24 87.0 0.3 4.9 4 1 0 5 5 5 2 Dimerisation and cyclophilin-binding domain of Mon2 DUF737 PF05300.11 EFA83259.1 - 0.37 11.1 12.9 1.3 9.3 6.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF737) Epimerase PF01370.21 EFA83260.1 - 3e-11 43.3 0.2 8.2e-11 41.8 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFA83260.1 - 1.7e-06 27.8 0.6 0.0035 16.9 0.2 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EFA83260.1 - 6.5e-06 26.1 0.0 8.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EFA83260.1 - 8.7e-05 22.8 0.3 0.00019 21.7 0.3 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 EFA83260.1 - 0.0028 17.1 0.1 0.0049 16.4 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EFA83260.1 - 0.0077 15.7 0.3 0.15 11.5 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 EFA83260.1 - 0.021 14.8 0.2 0.049 13.6 0.2 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 EFA83260.1 - 0.024 14.8 0.0 0.056 13.6 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFA83260.1 - 0.065 13.8 0.1 0.17 12.5 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent adh_short_C2 PF13561.6 EFA83260.1 - 0.12 12.0 0.2 0.19 11.3 0.2 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 EFA83260.1 - 0.4 10.5 1.5 1.1 9.2 0.3 2.0 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CTP_synth_N PF06418.14 EFA83261.1 - 2.7e-125 417.0 0.1 3.6e-125 416.6 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EFA83261.1 - 7.8e-56 188.9 0.0 1.3e-55 188.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFA83261.1 - 0.00045 20.0 0.1 0.01 15.6 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 UcrQ PF02939.16 EFA83262.1 - 8.5e-13 48.0 0.4 1.1e-12 47.6 0.3 1.3 1 1 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EFA83262.1 - 2.2e-07 31.2 0.0 3.1e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 LRR_6 PF13516.6 EFA83264.1 - 2.5e-15 55.1 47.0 0.0079 16.2 0.0 12.0 11 0 0 11 11 11 8 Leucine Rich repeat LRR_9 PF14580.6 EFA83264.1 - 0.026 14.0 2.0 0.034 13.7 0.6 2.0 2 0 0 2 2 2 0 Leucine-rich repeat BORCS8 PF10167.9 EFA83266.1 - 1.5e-34 118.3 5.0 1.5e-34 118.3 5.0 2.1 2 0 0 2 2 2 1 BLOC-1-related complex sub-unit 8 Nre_C PF04895.12 EFA83266.1 - 0.27 11.1 0.7 0.94 9.4 0.0 2.2 2 0 0 2 2 2 0 Archaeal Nre, C-terminal Glyoxalase_2 PF12681.7 EFA83266.1 - 2.5 8.0 6.2 0.35 10.8 1.4 2.0 2 1 0 2 2 2 0 Glyoxalase-like domain Apolipoprotein PF01442.18 EFA83269.1 - 1.6e-22 80.3 52.1 7.2e-12 45.6 21.6 3.6 1 1 2 3 3 3 3 Apolipoprotein A1/A4/E domain YtxH PF12732.7 EFA83269.1 - 1e-14 54.8 98.2 0.00065 20.2 7.5 8.9 2 1 4 6 6 5 5 YtxH-like protein DUF883 PF05957.13 EFA83269.1 - 1.3e-12 48.2 56.0 0.012 16.2 0.5 7.7 1 1 8 9 9 9 9 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 EFA83269.1 - 1.5e-10 41.4 66.7 0.00078 19.6 7.7 4.5 1 1 4 5 5 5 5 Apolipophorin-III precursor (apoLp-III) Synuclein PF01387.17 EFA83269.1 - 4.2e-07 30.3 66.9 0.023 14.9 3.8 6.9 2 2 5 7 7 7 6 Synuclein Prominin PF05478.11 EFA83269.1 - 0.006 14.6 37.8 0.1 10.6 17.6 3.2 1 1 2 3 3 3 2 Prominin ApoO PF09769.9 EFA83269.1 - 0.008 16.1 20.1 7.4 6.5 0.7 6.3 1 1 4 6 6 6 2 Apolipoprotein O DUF1451 PF07295.11 EFA83269.1 - 0.011 15.8 57.0 0.29 11.2 6.4 6.0 1 1 5 6 6 6 0 Zinc-ribbon containing domain Syntaxin_2 PF14523.6 EFA83269.1 - 0.18 12.2 47.1 1.7 9.1 1.3 7.3 1 1 6 7 7 7 0 Syntaxin-like protein DUF842 PF05811.13 EFA83269.1 - 0.22 11.2 35.4 0.39 10.4 6.6 4.8 1 1 3 4 4 3 0 Eukaryotic protein of unknown function (DUF842) Exonuc_VII_L PF02601.15 EFA83269.1 - 0.35 10.4 40.7 5.9 6.4 10.3 3.4 1 1 2 3 3 3 0 Exonuclease VII, large subunit Perilipin PF03036.16 EFA83269.1 - 0.72 8.8 48.9 2.4 7.1 10.9 4.1 1 1 2 3 3 3 0 Perilipin family DUF5330 PF17264.2 EFA83269.1 - 3.2 7.8 9.6 15 5.7 0.2 5.6 3 1 3 7 7 7 0 Family of unknown function (DUF5330) Baculo_PEP_C PF04513.12 EFA83269.1 - 3.3 7.7 15.4 22 5.1 0.1 4.8 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Myosin-VI_CBD PF16521.5 EFA83269.1 - 5.6 7.0 13.0 11 6.1 0.3 4.5 1 1 3 4 4 4 0 Myosin VI cargo binding domain Condensin2nSMC PF12422.8 EFA83269.1 - 6 7.0 6.5 3.1 8.0 0.4 3.3 2 2 2 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit DEAD PF00270.29 EFA83270.1 - 3.4e-52 176.7 0.0 1.1e-51 175.1 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA83270.1 - 4.3e-23 81.8 0.1 4.3e-23 81.8 0.1 3.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EFA83270.1 - 7.7e-12 45.3 9.9 7.7e-12 45.3 9.9 4.9 5 2 0 5 5 5 1 DBP10CT (NUC160) domain DNA_pol3_chi PF04364.13 EFA83270.1 - 0.067 13.4 0.0 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase III chi subunit, HolC AAA_22 PF13401.6 EFA83270.1 - 0.11 12.8 2.5 0.2 11.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain Dynein_IC2 PF11540.8 EFA83270.1 - 0.19 11.7 1.9 0.55 10.2 0.1 2.4 2 0 0 2 2 2 0 Cytoplasmic dynein 1 intermediate chain 2 Peptidase_M66 PF10462.9 EFA83271.1 - 1.7e-81 273.5 0.5 2.4e-81 273.1 0.5 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.6 EFA83271.1 - 0.0097 16.4 0.1 0.019 15.5 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EFA83271.1 - 0.022 14.6 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Matrixin Reprolysin_5 PF13688.6 EFA83271.1 - 0.034 14.3 0.1 0.056 13.6 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Metallopep PF12044.8 EFA83271.1 - 0.11 11.0 0.3 0.17 10.4 0.3 1.1 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_4 PF13583.6 EFA83271.1 - 0.29 10.7 2.4 0.33 10.5 0.9 1.6 1 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like E7 PF00527.18 EFA83274.1 - 0.12 12.5 0.1 0.12 12.5 0.1 3.5 2 1 0 2 2 2 0 E7 protein, Early protein DUF5090 PF17009.5 EFA83275.1 - 1.7 8.5 7.3 0.15 12.0 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5090) Hydrolase_4 PF12146.8 EFA83276.1 - 4.3e-17 62.2 0.0 2.3e-12 46.7 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA83276.1 - 1.6e-07 31.3 0.0 1.6e-07 31.3 0.0 3.1 3 1 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EFA83276.1 - 7.5e-07 29.0 6.4 0.0016 18.1 0.0 3.1 3 0 0 3 3 3 2 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 EFA83276.1 - 0.0004 20.1 1.1 0.00084 19.1 0.0 2.0 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EFA83276.1 - 0.013 16.1 0.0 0.031 14.9 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFA83276.1 - 0.017 14.6 3.2 0.027 14.0 0.2 2.4 2 1 0 2 2 2 0 Prolyl oligopeptidase family Mcm10 PF09332.11 EFA83276.1 - 0.45 9.9 11.4 0.64 9.4 11.4 1.3 1 0 0 1 1 1 0 Mcm10 replication factor SUIM_assoc PF16619.5 EFA83276.1 - 0.93 9.6 23.1 7.1e+02 0.4 23.1 3.4 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Androgen_recep PF02166.16 EFA83276.1 - 4.3 6.1 18.7 6.3 5.5 18.7 1.1 1 0 0 1 1 1 0 Androgen receptor RPN13_C PF16550.5 EFA83277.1 - 1e-20 74.0 0.1 1.8e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 EFA83277.1 - 2.3e-20 72.9 0.1 4e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor MSP1_C PF07462.11 EFA83277.1 - 0.041 12.6 3.2 0.056 12.1 3.2 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Mucin PF01456.17 EFA83277.1 - 1.8 8.6 22.4 3.3 7.7 22.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 EFA83277.1 - 3.1 8.2 11.1 6 7.3 11.1 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin ubiquitin PF00240.23 EFA83278.1 - 1.8e-12 46.8 0.3 2.8e-12 46.2 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA83278.1 - 3.3e-05 23.6 0.4 4.8e-05 23.1 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFA83278.1 - 0.062 13.9 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain IL1 PF00340.19 EFA83278.1 - 0.072 12.8 0.3 0.19 11.4 0.1 1.7 1 1 1 2 2 2 0 Interleukin-1 / 18 Rad60-SLD_2 PF13881.6 EFA83278.1 - 0.075 13.1 0.0 0.12 12.5 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Aminotran_1_2 PF00155.21 EFA83279.1 - 8.2e-53 179.8 0.0 9.7e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFA83279.1 - 0.0018 17.3 0.0 0.0026 16.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFA83279.1 - 0.0042 16.4 0.0 0.0064 15.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EFA83279.1 - 0.022 13.3 0.0 0.036 12.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFA83279.1 - 0.16 11.2 0.0 0.34 10.1 0.0 1.4 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_C48 PF02902.19 EFA83280.1 - 2.4e-34 119.1 1.5 2.4e-34 119.1 1.5 2.0 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain p450 PF00067.22 EFA83281.1 - 3.5e-81 273.3 0.1 4.3e-81 273.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 EFhand_Ca_insen PF08726.10 EFA83281.1 - 0.076 13.1 0.0 2.6 8.2 0.0 2.7 3 0 0 3 3 3 0 Ca2+ insensitive EF hand p450 PF00067.22 EFA83282.1 - 5.5e-59 200.1 0.0 6.7e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EFA83283.1 - 1.8e-18 66.6 0.1 2e-18 66.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 RCC1 PF00415.18 EFA83284.1 - 3.4e-87 286.9 15.1 3.5e-14 53.2 0.2 7.9 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA83284.1 - 9.6e-48 159.1 26.0 2.3e-07 30.4 0.1 7.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFA83284.1 - 1.8e-23 82.9 7.0 5e-15 55.7 0.5 3.4 3 0 0 3 3 3 2 BTB/POZ domain Hira PF07569.11 EFA83284.1 - 0.043 13.5 0.2 25 4.5 0.0 4.0 4 1 0 4 4 4 0 TUP1-like enhancer of split GAD-like PF08887.11 EFA83284.1 - 0.061 13.1 0.1 3 7.7 0.0 3.6 4 0 0 4 4 4 0 GAD-like domain COesterase PF00135.28 EFA83285.1 - 6e-85 286.0 1.4 1.5e-34 119.7 0.0 3.0 1 1 2 3 3 3 3 Carboxylesterase family R2K_3 PF14243.6 EFA83286.1 - 0.048 13.7 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 COesterase PF00135.28 EFA83287.1 - 1.3e-73 248.7 0.0 1.8e-73 248.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA83287.1 - 7.2e-06 26.0 0.1 6.9e-05 22.8 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFA83288.1 - 1e-23 84.0 1.5 1.2e-23 83.8 1.5 1.0 1 0 0 1 1 1 1 Carboxylesterase family R2K_3 PF14243.6 EFA83289.1 - 0.0091 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EFA83289.1 - 0.025 14.4 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 PIP5K PF01504.18 EFA83290.1 - 8.4e-20 71.1 1.6 8.4e-20 71.1 1.6 2.6 3 0 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF2229 PF09989.9 EFA83290.1 - 0.024 14.3 0.2 0.024 14.3 0.2 2.1 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Exonuc_VII_L PF02601.15 EFA83290.1 - 0.054 13.1 11.7 0.41 10.2 1.5 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit AAA_23 PF13476.6 EFA83290.1 - 0.057 13.9 14.2 0.066 13.7 3.8 2.4 2 0 0 2 2 2 0 AAA domain Cwf_Cwc_15 PF04889.12 EFA83290.1 - 0.12 12.1 21.1 0.22 11.2 5.3 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF3365 PF11845.8 EFA83290.1 - 0.31 11.4 5.1 3.4 8.0 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) EMC3_TMCO1 PF01956.16 EFA83290.1 - 0.36 10.6 13.6 0.84 9.4 5.8 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF4407 PF14362.6 EFA83290.1 - 1.3 8.4 15.6 0.74 9.1 5.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 EFA83290.1 - 2.8 8.0 26.1 0.91 9.6 3.8 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Complex1_LYR_2 PF13233.6 EFA83290.1 - 4.1 8.2 14.8 2.5 8.9 6.1 2.6 2 0 0 2 2 2 0 Complex1_LYR-like Maf1 PF09174.10 EFA83290.1 - 7.4 6.7 10.1 1.5 8.9 0.8 2.7 2 0 0 2 2 2 0 Maf1 regulator BTB_2 PF02214.22 EFA83292.1 - 4.9e-21 74.9 0.2 1.3e-20 73.5 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 EFA83292.1 - 2.8e-12 46.7 0.0 1e-11 44.8 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain DUF4378 PF14309.6 EFA83292.1 - 0.015 15.7 0.0 0.025 14.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) Secretin_N_2 PF07655.13 EFA83292.1 - 0.019 15.5 2.2 0.019 15.5 2.2 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Phage_connect_1 PF05135.13 EFA83292.1 - 0.091 13.3 2.5 8.7 6.9 0.4 3.2 3 0 0 3 3 3 0 Phage gp6-like head-tail connector protein Surp PF01805.20 EFA83293.1 - 1.1e-06 28.5 0.0 1.1e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 Surp module Smg4_UPF3 PF03467.15 EFA83294.1 - 8.8e-17 61.7 1.0 1.2e-16 61.2 1.0 1.1 1 0 0 1 1 1 1 Smg-4/UPF3 family zf-MYND PF01753.18 EFA83295.1 - 1.4e-06 28.3 5.9 3.5e-06 27.0 5.9 1.8 1 0 0 1 1 1 1 MYND finger Meleagrin PF08189.11 EFA83295.1 - 0.16 11.7 4.4 0.37 10.5 0.3 2.9 3 0 0 3 3 3 0 Meleagrin/Cygnin family Tnp_zf-ribbon_2 PF13842.6 EFA83295.1 - 2.7 8.9 6.6 25 5.8 2.2 2.7 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon AAA_23 PF13476.6 EFA83296.1 - 0.0025 18.3 14.9 0.0028 18.2 14.9 1.1 1 0 0 1 1 1 1 AAA domain DUF1690 PF07956.11 EFA83296.1 - 0.007 16.8 13.3 0.0081 16.6 13.3 1.2 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Caudo_TAP PF02413.17 EFA83296.1 - 0.02 15.0 12.1 0.38 10.9 0.2 2.1 1 1 1 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK FlxA PF14282.6 EFA83296.1 - 0.061 13.3 4.4 0.061 13.3 4.4 2.1 1 1 1 2 2 2 0 FlxA-like protein DUF724 PF05266.14 EFA83296.1 - 0.077 12.8 15.9 0.1 12.4 15.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Ran-binding PF05508.11 EFA83296.1 - 0.095 11.7 7.3 0.12 11.3 7.3 1.1 1 0 0 1 1 1 0 RanGTP-binding protein DUF3573 PF12097.8 EFA83296.1 - 0.12 11.2 0.8 0.11 11.2 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Casc1_N PF15927.5 EFA83296.1 - 0.2 11.3 16.8 0.24 11.1 16.8 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Allexi_40kDa PF05549.11 EFA83296.1 - 0.22 11.0 5.5 0.22 11.0 5.5 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF262 PF03235.14 EFA83296.1 - 0.22 11.7 9.9 0.25 11.5 9.9 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF262 Selenoprotein_S PF06936.11 EFA83296.1 - 0.36 10.6 13.3 0.43 10.4 13.3 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) V_ATPase_I PF01496.19 EFA83296.1 - 0.41 8.5 9.7 0.41 8.5 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 EFA83296.1 - 0.53 8.8 14.1 0.56 8.7 14.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A RAP1 PF07218.11 EFA83296.1 - 0.59 8.3 13.9 0.67 8.2 13.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4407 PF14362.6 EFA83296.1 - 0.81 9.0 7.3 0.9 8.8 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1266 PF06889.11 EFA83296.1 - 0.97 9.5 6.9 1.2 9.2 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) HSP70 PF00012.20 EFA83296.1 - 1.1 7.4 18.1 1.2 7.2 18.1 1.0 1 0 0 1 1 1 0 Hsp70 protein PBP_sp32 PF07222.12 EFA83296.1 - 1.4 8.3 8.5 1.6 8.1 8.5 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PPL5 PF18168.1 EFA83296.1 - 2.2 7.5 11.2 2.3 7.4 11.2 1.0 1 0 0 1 1 1 0 Prim-pol family 5 WDCP PF15390.6 EFA83296.1 - 2.3 6.5 8.9 2.4 6.5 8.9 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Exonuc_VII_L PF02601.15 EFA83296.1 - 2.7 7.5 10.4 2.9 7.4 10.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALMT PF11744.8 EFA83296.1 - 3.7 6.3 7.4 3.8 6.2 7.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Connexin PF00029.19 EFA83296.1 - 4.2 7.1 8.0 4.5 6.9 8.0 1.1 1 0 0 1 1 1 0 Connexin CLN3 PF02487.17 EFA83296.1 - 4.2 6.3 5.8 4.3 6.3 5.8 1.0 1 0 0 1 1 1 0 CLN3 protein SlyX PF04102.12 EFA83296.1 - 5.4 7.7 8.8 0.54 10.9 1.1 2.4 2 1 0 2 2 2 0 SlyX Csm1_N PF18504.1 EFA83296.1 - 5.4 7.4 22.0 0.25 11.7 8.2 2.8 1 1 1 2 2 2 0 Csm1 N-terminal domain Atg14 PF10186.9 EFA83296.1 - 5.9 5.9 14.5 6.8 5.7 14.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IATP PF04568.12 EFA83296.1 - 6.7 7.2 23.8 0.075 13.5 10.0 3.0 1 1 2 3 3 2 0 Mitochondrial ATPase inhibitor, IATP AAA_11 PF13086.6 EFA83296.1 - 6.8 6.4 12.6 6.5 6.4 12.6 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 EFA83296.1 - 6.9 5.3 8.9 7 5.3 8.9 1.0 1 0 0 1 1 1 0 Presenilin eIF-1a PF01176.19 EFA83297.1 - 2.6e-12 46.3 0.1 3.8e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 NOA36 PF06524.12 EFA83297.1 - 0.43 9.9 13.4 0.48 9.7 13.4 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EFA83297.1 - 0.43 10.3 13.3 0.59 9.8 13.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SURF2 PF05477.11 EFA83297.1 - 3.4 7.3 8.9 3.9 7.1 8.9 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) YL1 PF05764.13 EFA83297.1 - 6.4 6.8 13.5 8.2 6.5 13.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein SDA1 PF05285.12 EFA83297.1 - 6.9 6.0 15.0 8.6 5.7 15.0 1.2 1 0 0 1 1 1 0 SDA1 Amidohydro_1 PF01979.20 EFA83299.1 - 4.1e-71 240.1 0.0 4.8e-71 239.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFA83299.1 - 1.2e-09 38.2 0.0 0.0004 20.0 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Kelch_6 PF13964.6 EFA83300.1 - 8.3e-08 32.2 7.2 0.0055 16.9 0.0 5.1 5 0 0 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA83300.1 - 7.5e-06 26.0 5.4 1.4e-05 25.1 5.4 1.4 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA83300.1 - 0.00034 20.8 0.1 15 6.1 0.0 4.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Cep57_CLD PF14073.6 EFA83300.1 - 0.022 14.8 1.1 0.051 13.6 1.1 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 SBBP PF06739.11 EFA83300.1 - 0.15 12.1 0.3 0.15 12.1 0.3 2.9 2 1 0 2 2 2 0 Beta-propeller repeat UN_NPL4 PF11543.8 EFA83300.1 - 0.99 9.9 5.6 4.6 7.8 0.2 4.0 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 DUF5074 PF16819.5 EFA83300.1 - 2 8.5 10.1 6.2 6.9 0.0 4.3 3 1 2 5 5 5 0 Domain of unknown function (DUF5074) Kelch_6 PF13964.6 EFA83301.1 - 1.3e-09 38.0 3.0 0.014 15.7 0.0 5.0 6 0 0 6 6 6 2 Kelch motif zf-B_box PF00643.24 EFA83301.1 - 0.00026 21.1 10.4 0.00048 20.2 10.4 1.4 1 0 0 1 1 1 1 B-box zinc finger Cep57_CLD PF14073.6 EFA83301.1 - 0.0038 17.3 0.5 0.0038 17.3 0.5 1.9 2 0 0 2 2 2 1 Centrosome localisation domain of Cep57 Kelch_3 PF13415.6 EFA83301.1 - 0.0076 16.5 0.2 2.8 8.3 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain SBBP PF06739.11 EFA83301.1 - 0.024 14.6 6.2 0.15 12.1 0.3 3.4 2 0 0 2 2 2 0 Beta-propeller repeat Kelch_4 PF13418.6 EFA83301.1 - 0.43 10.6 8.3 21 5.2 0.0 4.6 5 0 0 5 5 5 0 Galactose oxidase, central domain HSDR_N_2 PF13588.6 EFA83301.1 - 1.6 8.7 7.4 0.28 11.2 0.3 2.8 3 0 0 3 3 3 0 Type I restriction enzyme R protein N terminus (HSDR_N) APG6_N PF17675.1 EFA83301.1 - 6 7.4 8.1 0.57 10.7 1.8 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region ArfGap PF01412.18 EFA83301.1 - 6.7 6.8 13.3 0.49 10.5 6.9 2.4 2 1 1 3 3 3 0 Putative GTPase activating protein for Arf Hydrolase_3 PF08282.12 EFA83302.1 - 6.5e-63 212.8 0.1 7.4e-63 212.7 0.1 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EFA83302.1 - 8.1e-11 41.9 0.0 2.8e-05 23.8 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EFA83302.1 - 0.00011 22.6 0.1 0.00066 20.0 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA83302.1 - 0.004 17.6 0.1 1.2 9.5 0.0 2.5 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Defensin_2 PF01097.18 EFA83302.1 - 0.016 15.1 0.2 0.042 13.8 0.2 1.7 1 0 0 1 1 1 0 Arthropod defensin HAD_2 PF13419.6 EFA83302.1 - 0.088 12.9 0.0 3.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF2207 PF09972.9 EFA83303.1 - 9.4e-05 21.4 1.9 0.00013 20.9 1.9 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Band_3_cyto PF07565.13 EFA83303.1 - 0.0049 16.7 1.9 0.0049 16.7 1.9 1.5 2 0 0 2 2 2 1 Band 3 cytoplasmic domain TFIIA PF03153.13 EFA83303.1 - 0.04 13.9 25.7 0.048 13.7 25.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ODV-E18 PF10717.9 EFA83303.1 - 0.19 11.6 5.0 0.24 11.3 3.0 2.2 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Membralin PF09746.9 EFA83303.1 - 0.51 9.3 6.1 0.83 8.6 6.1 1.3 1 0 0 1 1 1 0 Tumour-associated protein vATP-synt_AC39 PF01992.16 EFA83304.1 - 7.7e-120 400.4 1.4 8.6e-120 400.3 1.4 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit MRNIP PF15749.5 EFA83305.1 - 1.4e-25 90.1 10.8 1.4e-25 90.1 10.8 6.1 2 1 1 3 3 3 1 MRN-interacting protein TraB PF01963.17 EFA83306.1 - 1.1e-13 51.8 4.3 3e-06 27.3 0.0 2.8 2 1 0 2 2 2 2 TraB family PAS_10 PF13596.6 EFA83306.1 - 0.016 15.8 0.8 1.1 9.8 0.2 2.5 2 0 0 2 2 2 0 PAS domain RVP PF00077.20 EFA83306.1 - 0.12 12.8 0.0 0.36 11.2 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease CD36 PF01130.21 EFA83308.1 - 2.1e-42 145.2 1.5 7.8e-21 74.1 0.0 2.3 2 0 0 2 2 2 2 CD36 family Prominin PF05478.11 EFA83308.1 - 0.00053 18.1 0.0 0.00076 17.6 0.0 1.1 1 0 0 1 1 1 1 Prominin Aldo_ket_red PF00248.21 EFA83309.1 - 2.9e-43 148.1 0.1 1.4e-42 145.9 0.1 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family DDDD PF10161.9 EFA83309.1 - 0.0059 16.3 0.3 0.066 13.0 0.0 2.4 2 1 1 3 3 3 1 Putative mitochondrial precursor protein adh_short PF00106.25 EFA83310.1 - 5.7e-32 110.7 0.0 8.1e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA83310.1 - 3.1e-22 79.3 0.0 4.2e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA83310.1 - 0.00023 21.2 0.0 0.00041 20.3 0.0 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFA83310.1 - 0.032 14.1 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EFA83310.1 - 0.079 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding tRNA_anti-like PF12869.7 EFA83310.1 - 0.1 12.2 0.0 0.3 10.7 0.0 1.8 2 0 0 2 2 2 0 tRNA_anti-like UBX PF00789.20 EFA83311.1 - 8.6e-14 51.5 0.5 2.3e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 UBX domain TAF4 PF05236.14 EFA83311.1 - 1.5e-05 24.9 0.6 2.1e-05 24.4 0.6 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family ubiquitin PF00240.23 EFA83311.1 - 0.0011 18.7 0.0 0.12 12.2 0.0 3.2 3 0 0 3 3 3 1 Ubiquitin family Use1 PF09753.9 EFA83311.1 - 0.0071 16.1 6.8 0.014 15.2 6.8 1.4 1 0 0 1 1 1 1 Membrane fusion protein Use1 Ubiquitin_2 PF14560.6 EFA83311.1 - 0.051 14.0 0.2 0.64 10.5 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFA83311.1 - 0.89 9.4 0.0 0.89 9.4 0.0 2.5 2 1 0 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain THOC2_N PF16134.5 EFA83311.1 - 1.4 7.5 8.4 2.1 6.8 8.4 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Presenilin PF01080.17 EFA83311.1 - 6.3 5.4 5.0 11 4.7 5.0 1.3 1 0 0 1 1 1 0 Presenilin IPPT PF01715.17 EFA83312.1 - 5.7e-42 144.1 0.6 5.7e-42 144.1 0.6 2.4 2 1 0 2 2 2 1 IPP transferase zf-C2H2_jaz PF12171.8 EFA83312.1 - 1.2e-06 28.6 2.3 2.6e-06 27.6 2.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFA83312.1 - 5.4e-05 23.4 1.6 0.00013 22.2 1.6 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type IPT PF01745.16 EFA83312.1 - 0.00019 20.9 0.0 0.00045 19.7 0.0 1.6 1 0 0 1 1 1 1 Isopentenyl transferase DUF3381 PF11861.8 EFA83312.1 - 0.0089 15.8 14.1 0.0089 15.8 14.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3381) AAA_18 PF13238.6 EFA83312.1 - 0.012 16.1 0.0 0.012 16.1 0.0 3.5 3 2 0 3 3 3 0 AAA domain Hpr_kinase_C PF07475.12 EFA83312.1 - 0.022 14.3 0.1 0.022 14.3 0.1 2.0 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Ploopntkinase3 PF18751.1 EFA83312.1 - 0.049 13.5 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Cytidylate_kin PF02224.18 EFA83312.1 - 0.067 12.9 5.6 1.6 8.4 1.5 2.6 2 1 0 2 2 2 0 Cytidylate kinase AAA_33 PF13671.6 EFA83312.1 - 0.096 12.8 13.7 0.046 13.9 1.7 3.3 3 1 0 3 3 3 0 AAA domain MAS20 PF02064.15 EFA83312.1 - 0.097 12.8 0.1 0.097 12.8 0.1 3.2 3 0 0 3 3 3 0 MAS20 protein import receptor Hydin_ADK PF17213.3 EFA83312.1 - 0.29 11.4 0.1 0.29 11.4 0.1 3.7 3 1 0 3 3 2 0 Hydin Adenylate kinase-like domain CTU2 PF10288.9 EFA83312.1 - 0.4 10.9 17.7 1.4 9.2 13.4 2.9 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C2H2_2 PF12756.7 EFA83312.1 - 1.2 9.5 9.9 0.24 11.8 5.0 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Ribosomal_S11 PF00411.19 EFA83313.1 - 2.9e-44 150.0 1.9 3.8e-44 149.6 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 VASt PF16016.5 EFA83314.1 - 2.3e-11 44.3 0.4 2.3e-11 44.3 0.4 2.9 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain Trypan_PARP PF05887.11 EFA83314.1 - 0.23 11.5 1.2 0.38 10.7 1.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RNase_Zc3h12a PF11977.8 EFA83315.1 - 2.5e-26 92.3 1.3 4.1e-26 91.6 0.0 2.0 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain DUF5615 PF18480.1 EFA83315.1 - 0.057 13.2 0.1 0.17 11.7 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) Ribosomal_60s PF00428.19 EFA83315.1 - 0.5 11.0 7.2 0.15 12.7 0.8 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Mucin PF01456.17 EFA83315.1 - 2.4 8.1 8.3 1.8 8.5 2.2 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein fn3_6 PF17766.1 EFA83316.1 - 0.067 13.4 0.0 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 Fibronectin type-III domain Glyco_hydro_18 PF00704.28 EFA83317.1 - 0.00075 19.3 0.2 0.0013 18.6 0.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 7tm_3 PF00003.22 EFA83318.1 - 1.2e-39 136.4 24.7 1.8e-39 135.9 24.7 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA83318.1 - 7.8e-11 41.5 1.8 1.2e-10 40.9 1.8 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like DMT_YdcZ PF04657.13 EFA83318.1 - 0.0022 18.3 0.9 0.0022 18.3 0.9 2.8 2 1 1 3 3 3 1 Putative inner membrane exporter, YdcZ Trypan_PARP PF05887.11 EFA83318.1 - 0.67 9.9 8.7 1.2 9.1 8.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RhoGAP PF00620.27 EFA83321.1 - 4.8e-18 65.4 0.1 1.1e-17 64.3 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain DUF3439 PF11921.8 EFA83321.1 - 0.49 10.4 6.9 1.6 8.7 2.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) FtsH_ext PF06480.15 EFA83321.1 - 5.5 7.4 10.8 3.2 8.1 1.7 3.7 3 0 0 3 3 3 0 FtsH Extracellular EF-hand_6 PF13405.6 EFA83322.1 - 1.1e-09 37.5 3.4 0.0078 16.1 0.0 4.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EFA83322.1 - 1.5e-09 36.7 2.6 0.013 15.0 0.0 4.0 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFA83322.1 - 1.3e-08 35.1 3.8 3.7e-05 24.1 0.7 3.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA83322.1 - 5.4e-06 26.1 1.1 0.00078 19.2 1.1 3.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 EFA83322.1 - 0.00099 19.4 0.1 0.26 11.7 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain UBA PF00627.31 EFA83322.1 - 0.026 14.4 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain FSA_C PF10479.9 EFA83322.1 - 0.35 8.9 10.4 0.51 8.4 10.4 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 EFA83322.1 - 0.39 8.9 19.8 0.7 8.0 19.8 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 zf-RING_4 PF14570.6 EFA83322.1 - 0.81 9.5 3.1 2 8.3 3.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TFIIF_alpha PF05793.12 EFA83322.1 - 9.4 4.7 24.6 17 3.8 24.6 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM91_C PF14648.6 EFA83323.1 - 5e-138 460.5 2.4 3.4e-112 375.4 0.0 2.7 2 1 1 3 3 3 2 FAM91 C-terminus FAM91_N PF14647.6 EFA83323.1 - 1.6e-120 402.1 2.8 2.3e-120 401.6 2.8 1.2 1 0 0 1 1 1 1 FAM91 N-terminus SUIM_assoc PF16619.5 EFA83323.1 - 0.0016 18.5 0.5 0.0044 17.0 0.5 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Na_trans_assoc PF06512.13 EFA83323.1 - 0.037 14.3 0.1 0.069 13.4 0.1 1.4 1 0 0 1 1 1 0 Sodium ion transport-associated Methyltransf_25 PF13649.6 EFA83324.1 - 1.3e-10 41.8 0.1 5.6e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EFA83324.1 - 1.7e-10 40.8 0.1 2.8e-10 40.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFA83324.1 - 1.9e-09 37.5 0.1 4e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA83324.1 - 2.2e-08 34.6 0.0 7.4e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFA83324.1 - 2.1e-07 30.2 0.1 2.9e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 EFA83324.1 - 2.3e-07 30.8 0.0 1.2e-06 28.4 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EFA83324.1 - 1.6e-05 24.4 0.0 2.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EFA83324.1 - 4.3e-05 23.1 0.1 6.8e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EFA83324.1 - 0.00015 22.4 0.0 0.00043 21.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EFA83324.1 - 0.00018 21.4 0.0 0.00031 20.6 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.7 EFA83324.1 - 0.00053 19.9 0.1 0.00094 19.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EFA83324.1 - 0.00065 19.5 0.2 0.0011 18.8 0.2 1.3 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 EFA83324.1 - 0.0013 18.8 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 EFA83324.1 - 0.002 17.9 0.0 0.0037 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 EFA83324.1 - 0.01 15.3 2.1 0.083 12.3 0.2 2.9 1 1 1 3 3 3 0 Tellurite resistance protein TehB Ubie_methyltran PF01209.18 EFA83324.1 - 0.017 14.4 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EFA83324.1 - 0.077 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EFA83324.1 - 0.16 11.4 0.2 0.3 10.5 0.2 1.5 1 0 0 1 1 1 0 Putative methyltransferase PRKCSH_1 PF13015.6 EFA83326.1 - 2.4e-07 30.6 0.3 1.4e-06 28.1 0.1 2.0 1 1 1 2 2 2 1 Glucosidase II beta subunit-like protein DUF5553 PF17707.1 EFA83327.1 - 0.23 10.8 2.5 0.37 10.2 2.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5553) UL73_N PF12522.8 EFA83327.1 - 4.3 7.2 6.9 8 6.3 6.9 1.4 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein N terminal adh_short PF00106.25 EFA83328.1 - 1.3e-39 135.7 0.0 2e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA83328.1 - 4.8e-19 68.8 0.0 6.4e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA83328.1 - 5.1e-09 36.3 0.2 1.5e-08 34.8 0.2 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA83328.1 - 0.014 14.8 0.0 0.17 11.3 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFA83328.1 - 0.02 14.0 0.1 0.032 13.4 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Methyltr_RsmB-F PF01189.17 EFA83328.1 - 0.082 12.5 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Lactamase_B_6 PF16661.5 EFA83329.1 - 3.6e-15 55.9 2.9 6.2e-14 51.9 0.7 2.7 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EFA83329.1 - 5.8e-07 29.0 1.7 4.1e-06 26.2 0.4 2.6 2 1 0 2 2 2 1 Putative beta-lactamase-like family Beta-Casp PF10996.8 EFA83329.1 - 2.8e-06 27.6 0.0 7.7e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Peptidase_M24 PF00557.24 EFA83330.1 - 5.3e-57 192.9 0.1 7e-57 192.5 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFA83330.1 - 1.3e-33 115.4 0.0 2.2e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF2097 PF09870.9 EFA83330.1 - 0.23 11.7 1.6 1.5 9.1 0.1 2.9 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2097) Histone PF00125.24 EFA83331.1 - 2.3e-52 176.8 1.9 2.5e-52 176.7 1.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFA83331.1 - 2.9e-05 24.1 0.4 5.9e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFA83331.1 - 4.7e-05 23.7 0.0 7.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EFA83331.1 - 0.00086 19.9 0.4 0.0011 19.5 0.4 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain GlpM PF06942.12 EFA83332.1 - 0.025 15.0 0.9 0.052 14.0 0.9 1.5 1 0 0 1 1 1 0 GlpM protein CLP1_N PF16573.5 EFA83332.1 - 0.045 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 N-terminal beta-sandwich domain of polyadenylation factor TPR_17 PF13431.6 EFA83333.1 - 4e-37 123.9 6.5 4.5e-09 36.1 0.0 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat DUF1153 PF06627.11 EFA83333.1 - 0.0024 18.0 0.4 24 5.1 0.0 4.9 6 0 0 6 6 6 1 Protein of unknown function (DUF1153) Anth_Ig PF05587.13 EFA83333.1 - 0.048 14.0 0.7 44 4.5 0.0 3.8 4 0 0 4 4 4 0 Anthrax receptor extracellular domain TPR_11 PF13414.6 EFA83333.1 - 0.052 13.2 12.0 4.3 7.1 0.0 5.2 6 0 0 6 6 6 0 TPR repeat YjzC PF14168.6 EFA83333.1 - 0.056 13.8 0.0 24 5.4 0.0 3.7 3 1 0 3 3 3 0 YjzC-like protein DUF3255 PF11631.8 EFA83333.1 - 0.075 12.9 0.2 2.5 8.0 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3255) RNase_PH_C PF03725.15 EFA83333.1 - 1.4 9.0 5.0 16 5.6 0.2 3.8 3 2 1 4 4 4 0 3' exoribonuclease family, domain 2 CS PF04969.16 EFA83334.1 - 2.3e-17 63.8 0.2 3.4e-17 63.2 0.2 1.3 1 0 0 1 1 1 1 CS domain Vps55 PF04133.14 EFA83335.1 - 1.2e-35 122.0 8.2 1.4e-35 121.8 8.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Ank_2 PF12796.7 EFA83336.1 - 8.7e-23 80.7 5.7 3.9e-06 27.3 0.0 6.2 2 2 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83336.1 - 7.2e-19 67.9 10.3 7.4e-05 23.2 0.1 9.8 6 4 4 10 10 10 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83336.1 - 1.4e-12 46.6 2.3 29 5.7 0.0 11.6 12 2 2 14 14 14 0 Ankyrin repeat Ank_5 PF13857.6 EFA83336.1 - 5.3e-12 45.7 4.7 0.015 15.6 0.0 10.2 7 4 4 11 11 11 1 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA83336.1 - 0.0009 19.1 7.5 0.2 11.7 0.1 5.4 4 3 2 6 6 6 1 Domain of unknown function (DUF3447) DUF1529 PF07485.11 EFA83336.1 - 0.027 14.4 0.4 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1259) DUF2789 PF10982.8 EFA83336.1 - 0.047 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) GPCR_chapero_1 PF11904.8 EFA83336.1 - 0.054 12.9 0.0 1.1 8.6 0.0 2.1 1 1 0 2 2 2 0 GPCR-chaperone PYST-C1 PF09690.10 EFA83336.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) Ank_2 PF12796.7 EFA83337.1 - 2e-22 79.5 12.4 2.7e-05 24.7 0.3 6.1 1 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83337.1 - 3.4e-17 62.6 11.7 0.00037 21.0 0.4 8.6 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83337.1 - 9.1e-14 51.4 12.8 0.25 11.7 0.1 10.5 5 3 6 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83337.1 - 2.6e-11 42.7 7.9 18 6.3 0.0 11.1 12 1 1 13 13 13 2 Ankyrin repeat DUF5049 PF16468.5 EFA83337.1 - 0.092 12.7 0.4 29 4.7 0.0 4.6 4 3 1 5 5 5 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFA83337.1 - 0.21 12.1 0.6 2.2e+02 2.6 0.0 5.2 4 3 0 4 4 4 0 Ankyrin repeat Tma16 PF11176.8 EFA83338.1 - 8.8e-33 113.2 6.4 1.1e-32 112.9 6.4 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 DUF1106 PF06523.11 EFA83338.1 - 0.039 14.0 0.1 0.072 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) HK97-gp10_like PF04883.12 EFA83338.1 - 0.45 11.5 2.9 28 5.8 2.9 2.4 1 1 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component Ribosomal_L28e PF01778.17 EFA83339.1 - 2.1e-31 109.0 2.2 2.1e-31 109.0 2.2 1.4 1 1 0 1 1 1 1 Ribosomal L28e protein family Profilin PF00235.19 EFA83340.1 - 7.7e-41 139.3 0.2 8.5e-41 139.2 0.2 1.0 1 0 0 1 1 1 1 Profilin DUF1027 PF06265.11 EFA83340.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) T6SS_HCP PF05638.12 EFA83341.1 - 7.8e-06 26.3 0.1 1.5e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp DUF61 PF01886.16 EFA83341.1 - 0.059 13.4 0.4 0.16 12.0 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF61 HepII_C PF18675.1 EFA83341.1 - 0.12 12.5 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 Heparinase II C-terminal domain Glyoxalase PF00903.25 EFA83342.1 - 6.7e-22 78.0 0.0 7.7e-22 77.8 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFA83342.1 - 2.7e-08 34.1 0.0 9.3e-08 32.3 0.0 1.7 1 1 1 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EFA83342.1 - 8.3e-05 23.3 0.0 0.00019 22.2 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain CppA_N PF14506.6 EFA83342.1 - 0.002 18.2 0.0 0.0035 17.4 0.0 1.4 1 0 0 1 1 1 1 CppA N-terminal Glyoxalase_2 PF12681.7 EFA83342.1 - 0.0047 16.9 0.0 0.017 15.0 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EFA83342.1 - 0.17 12.0 0.0 20 5.2 0.0 2.1 1 1 0 2 2 2 0 Glyoxalase-like domain MitMem_reg PF13012.6 EFA83343.1 - 3e-26 92.0 1.6 5.8e-26 91.1 1.6 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFA83343.1 - 9.4e-22 77.2 0.1 4.1e-21 75.1 0.0 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RRM_1 PF00076.22 EFA83344.1 - 1.2e-26 92.3 0.0 1.5e-13 50.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Surp PF01805.20 EFA83344.1 - 3.9e-19 68.4 0.6 3.9e-19 68.4 0.6 2.8 4 0 0 4 4 4 1 Surp module RRM_occluded PF16842.5 EFA83344.1 - 2.7e-06 27.1 0.0 0.01 15.7 0.0 2.7 2 0 0 2 2 2 2 Occluded RNA-recognition motif CTD_bind PF04818.13 EFA83344.1 - 4.9e-06 27.3 0.1 1.7e-05 25.6 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_3 PF08777.11 EFA83344.1 - 0.00052 20.0 5.2 0.031 14.3 0.0 3.3 3 0 0 3 3 3 2 RNA binding motif DUF4523 PF15023.6 EFA83344.1 - 0.0078 16.1 5.9 0.17 11.7 0.0 3.5 3 1 0 3 3 3 1 Protein of unknown function (DUF4523) Presenilin PF01080.17 EFA83344.1 - 1.3 7.7 24.2 1.8 7.2 1.8 2.3 2 0 0 2 2 2 0 Presenilin CCSAP PF15748.5 EFA83344.1 - 1.5 8.9 29.9 0.53 10.4 18.1 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Tetraspanin PF00335.20 EFA83345.1 - 0.23 11.1 10.1 0.63 9.7 10.2 1.7 1 1 1 2 2 2 0 Tetraspanin family SLC3A2_N PF16028.5 EFA83345.1 - 1.4 8.5 4.6 0.79 9.3 2.2 1.8 1 1 1 2 2 2 0 Solute carrier family 3 member 2 N-terminus SUR7 PF06687.12 EFA83345.1 - 2.2 7.9 8.1 3.2 7.3 8.0 1.4 1 1 0 1 1 1 0 SUR7/PalI family zf-H2C2_2 PF13465.6 EFA83346.1 - 0.011 16.1 0.3 0.11 13.0 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.26 EFA83346.1 - 0.027 14.9 0.1 0.055 13.9 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Streptin-Immun PF11083.8 EFA83346.1 - 0.029 14.8 0.6 0.11 12.9 0.1 2.1 1 1 0 1 1 1 0 Lantibiotic streptin immunity protein zf-Di19 PF05605.12 EFA83346.1 - 0.049 13.9 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EFA83346.1 - 0.061 14.2 0.1 0.2 12.6 0.1 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger Myb_DNA-binding PF00249.31 EFA83346.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain FH2 PF02181.23 EFA83348.1 - 4.6e-82 276.1 7.7 4.6e-82 276.1 7.7 2.7 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFA83348.1 - 4.3e-38 130.9 0.5 4.3e-38 130.9 0.5 3.8 4 0 0 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EFA83348.1 - 7.2e-37 126.8 3.5 7.2e-37 126.8 3.5 3.6 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain C2 PF00168.30 EFA83348.1 - 3.2e-17 62.7 1.2 7e-17 61.6 0.6 1.9 2 0 0 2 2 2 1 C2 domain PI3K_C2 PF00792.24 EFA83348.1 - 0.00098 19.1 0.1 0.0028 17.6 0.1 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 CC2D2AN-C2 PF15625.6 EFA83348.1 - 0.01 15.6 0.1 0.027 14.2 0.1 1.7 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain Sigma54_CBD PF04963.13 EFA83348.1 - 0.015 15.2 2.3 0.023 14.6 0.4 2.3 2 0 0 2 2 2 0 Sigma-54 factor, core binding domain DUF489 PF04356.12 EFA83348.1 - 0.4 10.7 7.2 0.38 10.7 0.9 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF489) DUF4865 PF16157.5 EFA83348.1 - 1.2 9.1 5.0 1.2 9.1 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4865) DUF3464 PF11947.8 EFA83348.1 - 9 6.0 6.4 27 4.5 6.4 1.8 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 U-box PF04564.15 EFA83349.1 - 4.6e-16 58.8 0.6 1.5e-15 57.1 0.1 2.2 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 EFA83349.1 - 0.14 12.0 0.1 9.5 6.1 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit ThrE PF06738.12 EFA83350.1 - 1.9e-62 210.8 23.5 5.2e-53 179.9 2.2 2.4 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EFA83350.1 - 2.6e-08 34.0 32.0 5.7e-07 29.7 12.9 2.6 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE TruB_C_2 PF16198.5 EFA83350.1 - 0.032 14.4 0.0 0.032 14.4 0.0 2.3 2 1 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain MRP-L28 PF09812.9 EFA83350.1 - 0.13 12.4 10.7 0.26 11.4 10.7 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Activator_LAG-3 PF11498.8 EFA83350.1 - 1.8 7.5 35.7 3 6.7 35.7 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3573 PF12097.8 EFA83350.1 - 2.3 6.9 8.4 4.3 6.0 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) IFRD PF05004.13 EFA83351.1 - 1.3e-21 77.1 22.6 2.5e-20 72.8 22.6 2.2 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) SDA1 PF05285.12 EFA83351.1 - 0.0034 16.9 18.7 0.0052 16.3 18.7 1.4 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 EFA83351.1 - 0.065 11.4 22.4 0.099 10.8 22.4 1.3 1 0 0 1 1 1 0 Nop14-like family SID-1_RNA_chan PF13965.6 EFA83351.1 - 0.31 9.4 1.9 0.49 8.7 1.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MAS20 PF02064.15 EFA83351.1 - 0.33 11.1 6.7 1.1 9.3 6.7 1.9 1 0 0 1 1 1 0 MAS20 protein import receptor CDC45 PF02724.14 EFA83351.1 - 0.42 8.9 13.5 0.66 8.2 13.5 1.4 1 0 0 1 1 1 0 CDC45-like protein LON_substr_bdg PF02190.16 EFA83351.1 - 1.1 9.1 11.7 0.26 11.1 0.4 3.0 2 2 1 3 3 3 0 ATP-dependent protease La (LON) substrate-binding domain GEMIN8 PF15348.6 EFA83351.1 - 1.7 8.9 17.1 0.22 11.8 10.9 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 PDDEXK_6 PF04720.12 EFA83351.1 - 2.5 8.0 11.3 4.6 7.1 10.4 1.9 1 1 0 1 1 1 0 PDDEXK-like family of unknown function FRQ PF09421.10 EFA83351.1 - 6.3 4.7 13.2 9.4 4.1 13.2 1.2 1 0 0 1 1 1 0 Frequency clock protein RPA43_OB PF17875.1 EFA83351.1 - 7.9 7.1 7.4 20 5.8 7.4 1.7 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I CBS PF00571.28 EFA83352.1 - 1e-28 99.5 4.7 5.8e-10 39.5 0.0 4.3 4 0 0 4 4 4 4 CBS domain DUF3908 PF13048.6 EFA83352.1 - 0.0036 17.6 3.0 0.45 10.8 0.4 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF3908) HTH_47 PF16221.5 EFA83352.1 - 0.17 11.5 0.0 0.65 9.6 0.0 2.0 2 0 0 2 2 2 0 winged helix-turn-helix DENN PF02141.21 EFA83353.1 - 3.1e-39 134.9 2.8 3.1e-39 134.9 2.8 2.9 3 0 0 3 3 3 1 DENN (AEX-3) domain uDENN PF03456.18 EFA83353.1 - 0.00015 22.4 0.1 0.00015 22.4 0.1 3.3 3 0 0 3 3 3 1 uDENN domain DUF2340 PF10209.9 EFA83354.1 - 4e-27 95.1 6.1 5.6e-26 91.3 6.1 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) LIN37 PF15306.6 EFA83355.1 - 0.0081 16.4 7.7 0.0081 16.4 7.7 3.6 2 1 0 2 2 2 1 LIN37 RNA_pol_3_Rpc31 PF11705.8 EFA83356.1 - 3.2e-11 43.9 33.2 8e-11 42.6 32.9 1.7 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 EFA83356.1 - 0.037 12.3 18.8 0.05 11.8 18.8 1.1 1 0 0 1 1 1 0 Nop14-like family Mis14 PF08641.12 EFA83356.1 - 0.1 12.9 11.3 0.44 10.8 4.5 2.7 3 0 0 3 3 3 0 Kinetochore protein Mis14 like V_ATPase_I PF01496.19 EFA83356.1 - 2.1 6.2 4.7 2.6 5.9 4.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Metallophos PF00149.28 EFA83357.1 - 1.5e-16 61.5 0.5 3.1e-16 60.5 0.5 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA83357.1 - 4e-09 36.9 0.0 5.8e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EFA83357.1 - 0.011 15.1 0.0 0.061 12.6 0.0 2.1 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Snf7 PF03357.21 EFA83358.1 - 1.1e-36 126.1 25.1 1.6e-36 125.5 25.1 1.3 1 0 0 1 1 1 1 Snf7 Rad52_Rad22 PF04098.15 EFA83359.1 - 1.5e-30 106.1 0.3 1.5e-30 106.1 0.3 2.3 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein Mucin PF01456.17 EFA83359.1 - 1.3 9.0 13.8 3 7.8 13.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4407 PF14362.6 EFA83359.1 - 1.8 7.9 7.8 3.8 6.8 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_2 PF07719.17 EFA83360.1 - 1.4e-09 37.3 0.1 0.0029 17.6 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA83360.1 - 1.9e-08 33.8 0.5 0.0012 18.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat SET PF00856.28 EFA83360.1 - 4e-07 30.6 0.0 1.7e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 SET domain TPR_8 PF13181.6 EFA83360.1 - 0.00016 21.6 0.2 0.063 13.5 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA83360.1 - 0.0012 19.5 0.0 0.11 13.4 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA83360.1 - 0.0033 18.0 0.0 0.022 15.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83360.1 - 0.0059 16.3 0.2 3.7 7.3 0.0 2.5 2 0 0 2 2 2 2 TPR repeat Fis1_TPR_C PF14853.6 EFA83360.1 - 0.086 12.9 0.2 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 EFA83360.1 - 0.19 12.2 0.0 7.5 7.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4624 PF15417.6 EFA83361.1 - 0.0065 16.3 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4624) RRM_1 PF00076.22 EFA83362.1 - 2.1e-24 85.1 0.1 1.3e-12 47.3 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 EFA83362.1 - 3.6e-11 42.9 0.0 0.0002 21.3 0.0 2.4 2 0 0 2 2 2 2 DbpA RNA binding domain RRM_occluded PF16842.5 EFA83362.1 - 9.7e-07 28.6 0.0 4e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif RNA_bind PF08675.11 EFA83362.1 - 0.076 13.0 0.0 17 5.6 0.0 2.3 2 0 0 2 2 2 0 RNA binding domain RRM_5 PF13893.6 EFA83362.1 - 0.11 12.2 0.0 0.68 9.5 0.0 2.0 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pirin PF02678.16 EFA83363.1 - 2.2e-36 124.1 0.2 5.4e-36 122.8 0.1 1.7 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 EFA83363.1 - 1.8e-29 102.1 0.0 5.4e-29 100.6 0.0 1.8 2 0 0 2 2 2 1 Pirin C-terminal cupin domain KOW PF00467.29 EFA83363.1 - 0.0009 19.1 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 KOW motif Cupin_2 PF07883.11 EFA83363.1 - 0.12 12.2 0.4 3.7 7.3 0.1 2.3 2 0 0 2 2 2 0 Cupin domain EF-hand_7 PF13499.6 EFA83364.1 - 1.3e-11 44.8 0.0 1.8e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EFA83364.1 - 1.1e-10 41.2 0.5 1.2e-06 28.3 0.0 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFA83364.1 - 3.1e-10 38.9 0.4 0.0004 19.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA83364.1 - 4.2e-08 32.5 0.0 0.00021 21.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFA83364.1 - 4.2e-07 29.2 0.5 0.00053 19.4 0.2 2.3 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 EFA83364.1 - 0.06 13.7 0.0 0.12 12.7 0.0 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region MIP PF00230.20 EFA83365.1 - 1.3e-39 136.2 7.0 1.8e-39 135.8 7.0 1.2 1 0 0 1 1 1 1 Major intrinsic protein Pro_isomerase PF00160.21 EFA83366.1 - 2.8e-52 177.2 0.5 4.3e-52 176.6 0.5 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 EFA83366.1 - 1.8e-20 71.8 20.5 3.7e-08 32.8 1.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA83366.1 - 1.2e-15 56.2 14.5 4.2e-06 26.4 0.3 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA83366.1 - 8.3e-13 47.5 15.2 1.6e-05 24.7 0.8 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFA83366.1 - 2e-12 46.2 0.7 0.00057 19.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83366.1 - 3.6e-11 42.6 10.2 0.00035 20.2 0.1 3.4 2 1 1 3 3 3 3 TPR repeat TPR_12 PF13424.6 EFA83366.1 - 2.6e-10 40.5 2.6 0.00017 21.8 0.4 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFA83366.1 - 9.8e-08 32.2 6.0 0.0086 16.7 0.1 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFA83366.1 - 0.0002 21.5 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 EFA83366.1 - 0.00024 21.1 3.2 0.86 9.7 0.1 3.4 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EFA83366.1 - 0.00035 21.1 0.1 0.32 11.9 0.4 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA83366.1 - 0.00076 19.5 5.2 0.62 10.2 0.1 3.1 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 EFA83366.1 - 0.0012 19.4 0.2 0.89 10.3 0.8 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA83366.1 - 0.0017 18.6 0.1 0.0017 18.6 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 EFA83366.1 - 0.0048 17.2 3.2 0.37 11.1 0.0 2.6 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA83366.1 - 0.0051 17.3 6.2 0.019 15.5 1.9 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 EFA83366.1 - 0.013 15.4 0.0 0.052 13.6 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3808 PF10300.9 EFA83366.1 - 0.025 13.3 1.7 0.11 11.2 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3808) Casc1_N PF15927.5 EFA83366.1 - 0.027 14.2 2.0 0.04 13.6 2.0 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus ANAPC3 PF12895.7 EFA83366.1 - 0.043 14.1 10.9 0.37 11.1 2.5 3.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFA83366.1 - 0.087 12.7 2.6 7.7 6.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat PknG_TPR PF16918.5 EFA83366.1 - 0.098 11.4 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat FKBP_N PF01346.18 EFA83366.1 - 0.55 11.2 7.7 11 7.1 0.4 2.9 3 0 0 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase F420_oxidored PF03807.17 EFA83367.1 - 8.1e-15 55.2 1.3 1.3e-14 54.5 1.3 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFA83367.1 - 3.4e-06 27.3 0.8 3.4e-05 24.1 0.6 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 EFA83367.1 - 8.7e-06 25.6 0.3 1.8e-05 24.6 0.3 1.4 1 0 0 1 1 1 1 Rossmann-like domain Shikimate_DH PF01488.20 EFA83367.1 - 0.00022 21.3 0.0 0.00034 20.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFA83367.1 - 0.0026 17.2 0.1 0.0038 16.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EFA83367.1 - 0.0031 18.0 2.6 0.0093 16.4 1.7 2.1 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EFA83367.1 - 0.0057 16.6 0.5 0.084 12.8 0.5 2.1 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NmrA PF05368.13 EFA83367.1 - 0.031 13.8 0.2 0.066 12.8 0.2 1.6 1 0 0 1 1 1 0 NmrA-like family IlvN PF07991.12 EFA83367.1 - 0.033 13.7 0.3 0.051 13.1 0.3 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 EFA83367.1 - 0.042 13.9 1.0 0.071 13.2 1.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FKBP_C PF00254.28 EFA83368.1 - 4.2e-21 75.1 0.0 1.5e-20 73.3 0.0 2.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase OGG_N PF07934.12 EFA83368.1 - 3.5e-15 56.1 0.2 3.5e-15 56.1 0.2 2.7 2 1 0 2 2 1 1 8-oxoguanine DNA glycosylase, N-terminal domain ABM PF03992.16 EFA83368.1 - 4.4e-14 52.3 0.2 1.4e-13 50.7 0.0 2.0 2 0 0 2 2 1 1 Antibiotic biosynthesis monooxygenase TPR_1 PF00515.28 EFA83368.1 - 2.2e-13 49.4 8.8 7.1e-07 28.8 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA83368.1 - 8e-10 38.1 5.2 9.9e-07 28.4 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA83368.1 - 1.3e-06 28.2 7.8 4.9e-05 23.2 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA83368.1 - 0.00019 21.6 1.0 0.001 19.3 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Adaptin_binding PF10199.9 EFA83368.1 - 0.00057 20.5 0.0 0.0025 18.4 0.0 2.2 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 TPR_11 PF13414.6 EFA83368.1 - 0.0029 17.3 1.8 0.035 13.8 0.1 2.8 2 1 1 3 3 3 1 TPR repeat Myc_N PF01056.18 EFA83368.1 - 0.0038 17.2 5.2 0.0055 16.6 4.6 1.5 2 0 0 2 2 2 1 Myc amino-terminal region TPR_7 PF13176.6 EFA83368.1 - 0.0052 16.7 1.1 0.81 9.9 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA83368.1 - 0.0067 16.9 0.0 0.016 15.7 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat HHH PF00633.23 EFA83368.1 - 0.0078 16.0 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif TPR_15 PF13429.6 EFA83368.1 - 0.011 14.9 0.0 0.027 13.7 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA83368.1 - 0.013 16.1 0.6 0.17 12.6 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFA83368.1 - 0.014 16.1 0.0 0.073 13.9 0.0 2.2 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA83368.1 - 0.015 15.7 2.4 0.034 14.5 0.1 2.9 4 0 0 4 4 2 0 Tetratricopeptide repeat DDHD PF02862.17 EFA83368.1 - 0.088 13.0 5.6 0.18 12.0 3.0 2.2 2 0 0 2 2 2 0 DDHD domain TPR_9 PF13371.6 EFA83368.1 - 0.17 12.0 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA83368.1 - 0.6 10.4 4.4 1.1 9.6 0.2 2.5 1 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SID-1_RNA_chan PF13965.6 EFA83368.1 - 0.71 8.2 2.9 1.1 7.6 2.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SOBP PF15279.6 EFA83368.1 - 1 9.9 4.3 2.4 8.7 4.3 1.6 1 0 0 1 1 1 0 Sine oculis-binding protein PBP1_TM PF14812.6 EFA83368.1 - 1 9.8 7.8 2.4 8.6 7.8 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mucin PF01456.17 EFA83368.1 - 1.7 8.7 15.0 4 7.4 15.0 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 EFA83368.1 - 4.9 5.0 24.5 1.4 6.8 17.7 2.3 3 0 0 3 3 3 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 EFA83368.1 - 7.9 5.1 11.2 14 4.3 11.2 1.3 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 EFA83368.1 - 9.5 5.5 10.7 0.39 10.0 4.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Thioredox_DsbH PF03190.15 EFA83370.1 - 0.067 13.2 0.0 0.09 12.7 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF255 Kelch_6 PF13964.6 EFA83372.1 - 2e-15 56.5 6.4 5.8e-10 39.1 0.1 4.9 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA83372.1 - 0.0018 17.8 0.1 0.015 14.9 0.0 2.5 3 0 0 3 3 3 1 Kelch motif zf-B_box PF00643.24 EFA83372.1 - 0.002 18.2 9.9 0.0066 16.6 9.9 1.8 1 0 0 1 1 1 1 B-box zinc finger Kelch_2 PF07646.15 EFA83372.1 - 0.0086 16.0 0.1 0.031 14.3 0.1 2.0 1 0 0 1 1 1 1 Kelch motif Saccharop_dh_N PF04455.12 EFA83372.1 - 0.13 12.7 2.2 0.15 12.5 0.5 2.0 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region Nup54 PF13874.6 EFA83372.1 - 0.23 11.6 1.7 0.52 10.4 1.7 1.7 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Mgm101p PF06420.12 EFA83373.1 - 2.9e-75 251.5 0.0 4.6e-75 250.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 baeRF_family12 PF18856.1 EFA83373.1 - 0.21 12.2 0.2 22 5.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 IMUP PF15761.5 EFA83373.1 - 1.3 9.8 5.9 1.3 9.8 0.9 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 EFA83373.1 - 9.6 5.7 9.6 7 6.2 0.7 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein dUTPase PF00692.19 EFA83374.1 - 2.4e-08 33.7 0.0 1.1e-07 31.6 0.0 1.7 1 1 1 2 2 2 1 dUTPase ABC_tran PF00005.27 EFA83375.1 - 2e-27 96.4 0.2 4.9e-27 95.1 0.0 1.8 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 EFA83375.1 - 3.9e-05 23.6 0.5 0.0037 17.2 0.1 2.6 3 0 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EFA83375.1 - 0.00099 19.5 0.0 0.0021 18.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EFA83375.1 - 0.0037 17.1 4.9 0.055 13.3 0.2 2.9 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFA83375.1 - 0.0037 17.8 0.1 0.008 16.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFA83375.1 - 0.0075 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFA83375.1 - 0.021 14.5 0.1 0.056 13.2 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EFA83375.1 - 0.024 14.9 0.2 0.059 13.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFA83375.1 - 0.039 13.5 0.3 0.071 12.7 0.2 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFA83375.1 - 0.064 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 EFA83375.1 - 0.08 13.4 0.3 0.22 11.9 0.1 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RecA PF00154.21 EFA83375.1 - 0.085 12.3 0.3 0.63 9.5 0.1 2.4 2 1 1 3 3 3 0 recA bacterial DNA recombination protein cobW PF02492.19 EFA83375.1 - 0.12 11.9 0.4 0.28 10.8 0.2 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EFA83375.1 - 0.13 12.5 0.3 0.2 11.9 0.3 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EFA83375.1 - 0.14 11.7 0.8 6.2 6.3 0.1 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 EFA83375.1 - 0.28 11.1 2.0 0.44 10.4 0.2 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EFA83375.1 - 0.43 11.1 7.5 0.048 14.2 1.3 2.2 1 1 1 2 2 2 0 AAA domain ABC2_membrane PF01061.24 EFA83376.1 - 2.4e-07 30.4 0.4 3.1e-07 30.0 0.4 1.2 1 0 0 1 1 1 1 ABC-2 type transporter STATa_Ig PF18214.1 EFA83377.1 - 2.2e-48 163.3 1.7 2.2e-48 163.3 1.7 2.7 3 0 0 3 3 3 1 STATa Immunoglobulin-like domain EF-hand_12 PF17901.1 EFA83377.1 - 2.5e-39 133.6 1.5 2.5e-39 133.6 1.5 3.0 3 0 0 3 3 3 1 EF-hand fold domain Dict-STAT-coil PF09267.10 EFA83377.1 - 3.3e-37 127.3 17.0 3.3e-37 127.3 17.0 4.8 3 1 1 4 4 4 1 Dictyostelium STAT, coiled coil SH2 PF00017.24 EFA83377.1 - 1.1e-11 44.6 0.0 7.7e-11 41.9 0.0 2.5 2 0 0 2 2 2 1 SH2 domain FeoA PF04023.14 EFA83378.1 - 0.03 14.6 0.0 0.047 13.9 0.0 1.3 1 0 0 1 1 1 0 FeoA domain STAT2_C PF12188.8 EFA83378.1 - 0.071 13.0 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal Dickkopf_N PF04706.12 EFA83379.1 - 0.029 14.9 8.9 0.029 14.9 8.9 7.2 1 1 7 8 8 8 0 Dickkopf N-terminal cysteine-rich region Big_2 PF02368.18 EFA83379.1 - 0.21 11.5 1.5 0.38 10.7 1.5 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) IU_nuc_hydro PF01156.19 EFA83380.1 - 1.7e-19 70.5 0.0 2.2e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase WAP PF00095.21 EFA83381.1 - 0.00043 20.6 16.6 0.0011 19.3 16.6 1.7 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' RPN1_RPN2_N PF17781.1 EFA83382.1 - 1.5e-116 389.1 3.4 2e-116 388.7 3.4 1.2 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EFA83382.1 - 6.1e-30 103.0 0.0 1.3e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EFA83382.1 - 9.9e-27 92.0 17.3 0.0013 19.0 0.8 10.2 11 0 0 11 11 11 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFA83382.1 - 4.7e-08 33.3 0.1 0.0017 18.7 0.0 3.9 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EFA83382.1 - 6.6e-05 22.8 0.1 1.9 8.9 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat Utp13 PF08625.11 EFA83382.1 - 0.15 11.9 0.5 0.5 10.3 0.1 2.1 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain Macoilin PF09726.9 EFA83382.1 - 0.38 9.3 3.3 0.49 8.9 3.3 1.1 1 0 0 1 1 1 0 Macoilin family CarboxypepD_reg PF13620.6 EFA83384.1 - 5.6e-44 148.3 8.6 2e-07 31.2 0.2 9.7 10 0 0 10 10 10 8 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 EFA83384.1 - 5.2e-21 75.0 15.2 0.013 15.7 0.0 10.0 10 0 0 10 10 10 6 SdrD B-like domain CarbopepD_reg_2 PF13715.6 EFA83384.1 - 6.5e-19 67.7 17.0 7e-05 22.7 0.1 8.6 10 0 0 10 10 10 5 CarboxypepD_reg-like domain DUF2012 PF09430.10 EFA83384.1 - 4.5e-10 39.7 0.2 0.28 11.3 0.0 6.7 6 1 0 6 6 6 2 Protein of unknown function (DUF2012) SpaA PF17802.1 EFA83384.1 - 2.4e-07 31.0 5.1 0.33 11.3 0.0 7.7 7 1 0 7 7 7 2 Prealbumin-like fold domain MetallophosN PF16371.5 EFA83384.1 - 8.1e-05 22.8 2.8 0.011 16.0 0.2 4.9 5 0 0 5 5 5 1 N terminal of Calcineurin-like phosphoesterase fn3_3 PF14686.6 EFA83384.1 - 8.4e-05 22.3 0.7 0.2 11.5 0.0 5.2 5 1 0 6 6 6 1 Polysaccharide lyase family 4, domain II bMG3 PF11974.8 EFA83384.1 - 0.00083 19.3 2.3 0.24 11.4 0.0 4.9 6 0 0 6 6 6 1 Bacterial alpha-2-macroglobulin MG3 domain DUF2846 PF11008.8 EFA83384.1 - 0.001 19.0 0.1 2 8.5 0.0 5.1 5 0 0 5 5 5 1 Protein of unknown function (DUF2846) Big_6 PF17936.1 EFA83384.1 - 0.15 12.4 2.0 21 5.5 0.0 4.9 4 0 0 4 4 4 0 Bacterial Ig domain Big_3_5 PF16640.5 EFA83384.1 - 1.6 9.0 7.7 9.6 6.5 0.0 4.8 6 0 0 6 6 5 0 Bacterial Ig-like domain (group 3) HSP20 PF00011.21 EFA83385.1 - 1.2e-17 63.9 2.1 9.8e-11 41.7 0.9 2.2 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA83385.1 - 3e-08 33.1 0.0 1.7e-07 30.7 0.0 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFA83385.1 - 0.00077 20.4 1.5 0.013 16.5 0.1 2.3 2 0 0 2 2 2 1 CS domain FKBP26_C PF18046.1 EFA83385.1 - 0.0082 16.2 0.5 0.017 15.2 0.2 1.7 2 0 0 2 2 2 1 FKBP26_C-terminal DUF4193 PF13834.6 EFA83385.1 - 3.4 8.2 6.8 5.2 7.6 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) Sperm_Ag_HE2 PF05324.13 EFA83386.1 - 0.053 14.0 0.1 0.083 13.4 0.1 1.4 1 0 0 1 1 1 0 Sperm antigen HE2 HSP20 PF00011.21 EFA83387.1 - 1.6e-16 60.3 2.2 1.2e-09 38.2 0.9 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA83387.1 - 3.2e-08 33.0 0.1 1.8e-07 30.6 0.1 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFA83387.1 - 0.0023 18.9 0.8 0.012 16.6 0.1 2.2 2 0 0 2 2 2 1 CS domain FKBP26_C PF18046.1 EFA83387.1 - 0.0086 16.2 0.5 0.017 15.2 0.2 1.6 2 0 0 2 2 2 1 FKBP26_C-terminal CDC45 PF02724.14 EFA83387.1 - 0.26 9.5 8.0 0.25 9.6 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 EFA83387.1 - 1.2 8.3 2.4 1.4 8.0 2.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EFA83387.1 - 2.7 6.7 5.4 2.7 6.7 5.4 1.1 1 0 0 1 1 1 0 Presenilin FAINT PF04385.15 EFA83388.1 - 0.0087 16.1 1.3 0.01 15.9 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function, DUF529 HSP20 PF00011.21 EFA83390.1 - 2.6e-16 59.6 1.7 2.2e-09 37.4 0.7 2.4 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA83390.1 - 2.2e-08 33.5 0.1 3.4e-07 29.7 0.1 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFA83390.1 - 0.0062 17.5 4.4 0.049 14.7 2.3 2.6 1 1 1 2 2 2 1 CS domain FKBP26_C PF18046.1 EFA83390.1 - 0.0075 16.4 0.4 0.018 15.1 0.2 1.7 2 0 0 2 2 2 1 FKBP26_C-terminal TIG PF01833.24 EFA83392.1 - 2e-50 168.8 163.8 2.6e-11 43.4 6.2 17.2 17 0 0 17 17 17 12 IPT/TIG domain DNase_II PF03265.15 EFA83392.1 - 1.7e-25 90.0 0.2 1.7e-25 90.0 0.2 3.6 3 1 0 3 3 3 1 Deoxyribonuclease II SdrD_B PF17210.3 EFA83392.1 - 2.2e-09 37.5 4.7 5.7e-08 33.0 0.1 4.0 4 0 0 4 4 4 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA83392.1 - 2.9e-06 27.4 2.4 0.00028 21.1 0.0 3.9 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFA83392.1 - 0.015 15.3 0.0 0.069 13.2 0.0 2.1 1 0 0 1 1 1 0 CarboxypepD_reg-like domain DNase_II PF03265.15 EFA83393.1 - 9e-14 51.5 0.4 1.1e-13 51.2 0.4 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II Endotoxin_N PF03945.14 EFA83396.1 - 0.0021 17.8 0.8 0.005 16.6 0.0 2.0 2 0 0 2 2 2 1 delta endotoxin, N-terminal domain MMR1 PF08505.10 EFA83397.1 - 0.53 10.5 21.3 0.74 10.0 21.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Radial_spoke PF04712.12 EFA83397.1 - 0.65 8.9 15.2 0.85 8.5 15.2 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein DAG_kinase_N PF14513.6 EFA83397.1 - 1 9.6 19.7 1.5 9.0 19.7 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Spt20 PF12090.8 EFA83397.1 - 1.1 8.9 27.8 1.4 8.5 27.8 1.3 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 EFA83397.1 - 2 7.1 23.8 2.3 6.9 23.8 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EFA83397.1 - 2.3 7.2 25.5 2.8 6.9 25.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MCM_bind PF09739.9 EFA83397.1 - 2.8 6.3 23.6 3.4 6.0 23.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SUFU_C PF12470.8 EFA83397.1 - 2.9 7.9 10.3 4.2 7.4 10.3 1.3 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain Membralin PF09746.9 EFA83397.1 - 4.3 6.3 13.7 4.5 6.2 13.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 EFA83397.1 - 4.7 5.9 18.4 5.7 5.6 18.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM10 PF12519.8 EFA83397.1 - 6.4 5.5 19.1 7 5.4 19.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GREB1 PF15782.5 EFA83397.1 - 6.5 3.7 14.8 6.7 3.7 14.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Band_3_cyto PF07565.13 EFA83397.1 - 9.5 5.9 15.8 13 5.5 15.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2370 PF10176.9 EFA83397.1 - 9.7 5.8 9.2 14 5.3 9.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4825 PF16107.5 EFA83398.1 - 0.04 14.0 0.3 0.08 13.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) Comm PF15957.5 EFA83399.1 - 0.18 12.2 2.4 0.3 11.5 0.2 2.3 2 0 0 2 2 2 0 Commissureless AAA_2 PF07724.14 EFA83400.1 - 5.6e-05 23.3 0.0 0.00014 22.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFA83400.1 - 0.00038 20.9 0.0 0.00088 19.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA83400.1 - 0.005 17.2 0.1 1.3 9.4 0.1 2.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EFA83400.1 - 0.0054 16.7 0.1 0.9 9.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFA83400.1 - 0.0083 16.4 1.0 0.21 11.9 0.2 2.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA83400.1 - 0.0093 16.5 0.2 0.064 13.8 0.2 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFA83400.1 - 0.025 14.3 0.0 2.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EFA83400.1 - 0.038 14.0 1.0 0.11 12.5 0.0 2.3 3 1 0 3 3 3 0 AAA domain AAA_24 PF13479.6 EFA83400.1 - 0.061 13.0 0.0 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain HSP20 PF00011.21 EFA83401.1 - 2e-17 63.2 0.0 2.3e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family GH114_assoc PF14741.6 EFA83401.1 - 0.038 14.2 0.0 3.4 7.9 0.0 2.0 2 0 0 2 2 2 0 N-terminal glycosyl-hydrolase-114-associated domain FKBP26_C PF18046.1 EFA83401.1 - 0.1 12.7 0.1 1.6 8.9 0.0 2.1 2 0 0 2 2 2 0 FKBP26_C-terminal TFIIB PF00382.19 EFA83402.1 - 9e-19 67.3 0.1 5.1e-11 42.5 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EFA83402.1 - 1.5e-13 50.0 2.2 2.7e-13 49.2 2.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 EFA83402.1 - 0.00052 20.1 1.6 0.56 10.3 0.0 2.7 2 1 1 3 3 3 2 Cyclin, C-terminal domain A2L_zn_ribbon PF08792.10 EFA83402.1 - 0.015 15.0 1.6 3 7.6 0.1 2.6 2 0 0 2 2 2 0 A2L zinc ribbon domain CHASE9 PF17153.4 EFA83402.1 - 0.047 13.8 0.2 0.22 11.7 0.1 2.0 2 0 0 2 2 2 0 Periplasmic sensor domain, extracellular zf-ribbon_3 PF13248.6 EFA83402.1 - 2.5 7.6 5.0 6.6 6.3 0.1 2.7 3 0 0 3 3 3 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 EFA83402.1 - 2.5 8.0 5.3 28 4.7 0.2 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit DNA_RNApol_7kD PF03604.13 EFA83402.1 - 9.4 6.0 6.7 1.4 8.7 2.3 1.9 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Pribosyltran PF00156.27 EFA83403.1 - 3.5e-16 59.1 0.0 5.4e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFA83403.1 - 7.6e-05 22.2 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_3 PF15610.6 EFA83403.1 - 0.017 14.3 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 PRTase ComF-like AAA_28 PF13521.6 EFA83404.1 - 3e-32 112.1 0.0 3.5e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain Bromodomain PF00439.25 EFA83405.1 - 3e-21 75.3 1.5 1.1e-18 67.1 0.0 3.1 2 1 1 3 3 3 2 Bromodomain BET PF17035.5 EFA83405.1 - 5e-17 61.8 0.2 5e-17 61.8 0.2 3.2 3 0 0 3 3 3 1 Bromodomain extra-terminal - transcription regulation AHD PF17793.1 EFA83405.1 - 0.13 12.0 1.4 0.34 10.8 0.1 2.3 2 0 0 2 2 2 0 ANC1 homology domain (AHD) AAA_18 PF13238.6 EFA83406.1 - 2.7e-30 105.6 0.9 4.2e-30 105.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFA83406.1 - 5.8e-10 39.6 0.0 8.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 EFA83406.1 - 2.6e-08 34.0 1.9 4.2e-08 33.3 1.4 1.7 1 1 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EFA83406.1 - 0.0003 20.5 0.1 0.28 10.8 0.1 2.4 2 1 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 EFA83406.1 - 0.00034 20.8 0.1 0.0019 18.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA83406.1 - 0.054 13.8 0.4 0.11 12.8 0.3 1.9 1 1 0 1 1 1 0 AAA domain SKI PF01202.22 EFA83406.1 - 0.068 13.3 0.7 0.88 9.7 0.3 2.3 2 0 0 2 2 2 0 Shikimate kinase TsaE PF02367.17 EFA83406.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EFA83406.1 - 0.16 12.4 0.5 4 7.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA83406.1 - 8.6 6.9 8.2 25 5.4 8.2 1.9 1 1 0 1 1 1 0 ABC transporter Kelch_1 PF01344.25 EFA83407.1 - 4.9e-21 74.0 0.2 2.1e-06 27.2 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFA83407.1 - 3.4e-18 65.4 0.1 0.00043 20.2 0.0 4.3 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA83407.1 - 2.5e-17 62.5 0.5 6.4e-05 23.1 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EFA83407.1 - 5.5e-15 55.0 0.1 1.8e-05 24.6 0.0 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EFA83407.1 - 1.3e-14 53.5 0.7 0.012 15.6 0.0 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 EFA83407.1 - 1.1e-13 51.1 0.5 0.00025 21.2 0.0 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain MnmE_helical PF12631.7 EFA83409.1 - 6.2e-51 173.5 1.9 9.3e-51 172.9 1.9 1.3 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EFA83409.1 - 1.1e-38 132.1 0.0 2.7e-38 130.8 0.0 1.7 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EFA83409.1 - 1.7e-18 66.7 1.9 1.9e-18 66.6 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA83409.1 - 5e-06 26.1 0.2 1.3e-05 24.8 0.1 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA83409.1 - 1.4e-05 25.1 0.4 0.014 15.3 0.0 2.9 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFA83409.1 - 3.5e-05 23.4 0.1 0.0043 16.6 0.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFA83409.1 - 4e-05 23.7 0.1 0.0003 20.9 0.1 2.4 1 1 0 1 1 1 1 Dynamin family cobW PF02492.19 EFA83409.1 - 0.00029 20.5 0.1 0.011 15.4 0.1 2.4 1 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EFA83409.1 - 0.0023 18.4 1.9 0.012 16.1 0.5 2.8 1 1 1 2 2 2 1 ABC transporter AAA_28 PF13521.6 EFA83409.1 - 0.063 13.5 0.0 0.24 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFA83409.1 - 0.11 12.9 0.0 0.72 10.3 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFA83409.1 - 0.3 11.6 1.6 0.99 10.0 0.0 2.5 2 1 0 3 3 2 0 AAA domain HSP70 PF00012.20 EFA83410.1 - 5.9e-263 873.5 8.4 6.7e-263 873.3 8.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFA83410.1 - 1e-14 54.1 0.3 2.1e-13 49.8 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EFA83410.1 - 0.0023 17.7 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EFA83410.1 - 0.01 15.2 0.1 0.022 14.0 0.1 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase zf-C3HC4_3 PF13920.6 EFA83412.1 - 8.6e-09 35.1 8.6 8.6e-09 35.1 8.6 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA83412.1 - 0.0068 16.2 7.8 0.031 14.1 7.8 2.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFA83412.1 - 0.072 13.1 9.6 0.31 11.0 9.6 2.2 1 0 0 1 1 1 0 zinc-RING finger domain VWC PF00093.18 EFA83413.1 - 0.49 10.7 19.4 0.89 9.9 4.9 2.2 2 0 0 2 2 2 0 von Willebrand factor type C domain TFA2_Winged_2 PF18121.1 EFA83414.1 - 3.7e-13 48.9 3.3 2.9e-12 46.1 0.1 2.9 3 1 0 3 3 3 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EFA83414.1 - 6e-10 39.3 1.2 1.2e-09 38.3 0.1 2.1 2 0 0 2 2 2 1 TFIIE beta subunit core domain E2F_TDP PF02319.20 EFA83414.1 - 0.00049 20.1 0.1 0.59 10.2 0.0 2.5 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain STAT_alpha PF01017.20 EFA83414.1 - 0.071 13.0 0.5 0.18 11.7 0.5 1.7 1 0 0 1 1 1 0 STAT protein, all-alpha domain Cadherin_C PF01049.17 EFA83416.1 - 0.029 14.7 0.2 0.036 14.4 0.2 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic region 7tm_3 PF00003.22 EFA83418.1 - 6.1e-27 94.9 18.9 7.2e-22 78.3 9.9 2.4 1 1 1 2 2 2 2 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA83418.1 - 1.9e-18 66.5 0.3 2.6e-18 66.0 0.3 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like MARVEL PF01284.23 EFA83418.1 - 0.9 9.6 11.9 0.023 14.7 3.0 2.6 1 1 1 2 2 2 0 Membrane-associating domain WD40 PF00400.32 EFA83419.1 - 2e-30 104.4 25.7 2.1e-07 31.5 1.3 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83419.1 - 6.6e-18 64.8 0.7 3.6e-07 30.4 0.0 4.8 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA83419.1 - 6.1e-08 31.8 6.9 0.0042 15.8 0.8 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFA83419.1 - 0.0001 21.4 2.4 0.23 10.4 0.1 3.6 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EFA83419.1 - 0.00012 21.2 1.2 0.053 12.4 0.4 2.9 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EFA83419.1 - 0.0014 17.4 0.8 1.1 8.0 0.0 3.3 1 1 3 4 4 4 2 Nup133 N terminal like PQQ PF01011.21 EFA83419.1 - 0.036 14.0 0.1 0.098 12.6 0.1 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 EFA83419.1 - 0.05 12.1 0.0 0.14 10.7 0.0 1.7 1 1 0 1 1 1 0 Cytochrome D1 heme domain Frtz PF11768.8 EFA83419.1 - 0.064 11.6 0.0 0.85 7.9 0.0 1.9 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz bZIP_1 PF00170.21 EFA83420.1 - 5.2e-14 52.1 8.8 5.2e-14 52.1 8.8 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFA83420.1 - 2.8e-06 27.3 7.8 2.8e-06 27.3 7.8 3.4 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFA83420.1 - 8.1e-05 23.1 12.1 8.1e-05 23.1 12.1 2.6 2 1 0 2 2 2 1 bZIP Maf transcription factor GAS PF13851.6 EFA83420.1 - 0.0078 15.6 9.3 0.0078 15.6 9.3 2.3 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EFA83420.1 - 0.046 13.9 25.5 0.043 14.0 16.9 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF2730 PF10805.8 EFA83420.1 - 0.097 12.8 2.1 0.27 11.3 1.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) SlyX PF04102.12 EFA83420.1 - 0.13 12.9 0.2 0.13 12.9 0.2 3.3 3 0 0 3 3 3 0 SlyX DUF3381 PF11861.8 EFA83420.1 - 0.38 10.5 17.3 0.24 11.2 10.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3381) OmpH PF03938.14 EFA83420.1 - 3.1 8.2 14.5 2.5 8.5 2.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Kelch_1 PF01344.25 EFA83421.1 - 2.2e-42 142.4 3.6 1.3e-09 37.5 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFA83421.1 - 2e-41 139.0 8.2 1.7e-09 37.6 0.0 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFA83421.1 - 3.1e-37 126.2 6.5 1.4e-09 38.0 0.0 6.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA83421.1 - 5.3e-34 115.7 6.1 1.5e-08 34.4 0.1 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EFA83421.1 - 1.2e-30 104.3 12.9 2.2e-06 27.4 0.1 7.0 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFA83421.1 - 3.4e-28 97.4 9.6 4.6e-05 23.3 0.0 6.5 6 1 0 6 6 6 5 Galactose oxidase, central domain F-box PF00646.33 EFA83421.1 - 2.4e-06 27.3 0.3 4.5e-06 26.4 0.3 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA83421.1 - 5.9e-05 22.9 0.3 0.00012 21.9 0.0 1.7 2 0 0 2 2 2 1 F-box-like Ribonuc_2-5A PF06479.12 EFA83422.1 - 0.0097 16.1 0.4 0.022 14.9 0.4 1.7 1 0 0 1 1 1 1 Ribonuclease 2-5A Ins_beta PF03488.14 EFA83422.1 - 8.7 6.4 6.6 36 4.5 0.2 2.4 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type ABC2_membrane PF01061.24 EFA83423.1 - 6.5e-56 189.1 58.8 3.1e-38 131.3 21.7 4.0 4 1 1 5 5 4 3 ABC-2 type transporter ABC_tran PF00005.27 EFA83423.1 - 1.1e-51 174.9 0.6 4.2e-26 92.1 0.1 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA83423.1 - 4.1e-10 39.5 1.2 9.9e-06 25.1 0.1 3.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFA83423.1 - 4.3e-10 40.2 0.1 0.00016 22.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFA83423.1 - 8.6e-09 35.5 0.0 0.004 17.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EFA83423.1 - 9.6e-08 32.2 2.1 0.12 12.2 0.0 4.6 2 2 2 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA83423.1 - 2e-07 30.6 0.4 0.0047 16.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 EFA83423.1 - 2.3e-07 31.4 4.4 0.0014 19.2 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 EFA83423.1 - 4.7e-07 29.6 0.0 0.018 14.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFA83423.1 - 5.1e-07 30.0 0.7 0.036 14.3 0.1 3.0 2 1 0 2 2 2 2 AAA domain AAA PF00004.29 EFA83423.1 - 8.7e-07 29.4 0.1 0.00041 20.8 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFA83423.1 - 1.3e-06 28.5 0.0 0.025 14.5 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain Zeta_toxin PF06414.12 EFA83423.1 - 1.8e-06 27.4 0.0 0.0054 16.0 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_23 PF13476.6 EFA83423.1 - 2.5e-06 28.2 0.9 0.047 14.2 0.0 2.9 3 1 0 3 3 2 2 AAA domain AAA_28 PF13521.6 EFA83423.1 - 2.6e-06 27.8 0.1 0.0097 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EFA83423.1 - 3.1e-06 27.4 0.1 0.09 12.9 0.1 2.7 2 0 0 2 2 2 2 AAA domain PDR_CDR PF06422.12 EFA83423.1 - 5.4e-06 26.2 2.8 0.00016 21.5 0.1 3.4 3 0 0 3 3 2 1 CDR ABC transporter RNA_helicase PF00910.22 EFA83423.1 - 6.8e-06 26.4 0.0 0.019 15.4 0.0 2.9 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 EFA83423.1 - 1.3e-05 25.2 1.3 0.0065 16.4 0.1 2.4 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 EFA83423.1 - 2.2e-05 24.5 0.1 0.0057 16.7 0.1 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EFA83423.1 - 3e-05 23.8 0.3 0.025 14.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFA83423.1 - 7.5e-05 22.8 0.1 0.61 10.1 0.0 3.0 2 1 0 2 2 2 2 AAA domain NB-ARC PF00931.22 EFA83423.1 - 0.00017 20.8 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_7 PF12775.7 EFA83423.1 - 0.00019 21.0 0.2 0.0083 15.7 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 EFA83423.1 - 0.00025 21.0 0.1 0.052 13.6 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 EFA83423.1 - 0.00028 20.9 0.5 1.1 9.4 0.0 3.1 3 1 0 3 3 2 2 50S ribosome-binding GTPase IstB_IS21 PF01695.17 EFA83423.1 - 0.00037 20.3 0.0 0.21 11.3 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein PDR_assoc PF08370.11 EFA83423.1 - 0.00037 20.2 4.8 0.0054 16.4 0.8 3.1 2 0 0 2 2 2 1 Plant PDR ABC transporter associated ATPase_2 PF01637.18 EFA83423.1 - 0.00075 19.5 0.0 0.19 11.6 0.0 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Roc PF08477.13 EFA83423.1 - 0.0015 18.8 0.1 2.9 8.1 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RuvB_N PF05496.12 EFA83423.1 - 0.0028 17.4 0.9 0.057 13.2 0.1 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain PduV-EutP PF10662.9 EFA83423.1 - 0.0028 17.4 1.3 0.14 11.9 0.4 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Ploopntkinase3 PF18751.1 EFA83423.1 - 0.0043 17.0 0.2 0.17 11.8 0.0 2.2 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 NTPase_1 PF03266.15 EFA83423.1 - 0.0044 16.9 0.3 2.5 8.0 0.0 3.5 3 0 0 3 3 3 1 NTPase DUF815 PF05673.13 EFA83423.1 - 0.005 16.0 0.4 0.031 13.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EFA83423.1 - 0.0068 16.7 0.6 0.043 14.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFA83423.1 - 0.013 15.2 3.9 0.72 9.5 0.3 2.9 3 1 0 3 3 3 0 AAA domain ECF-ribofla_trS PF07155.12 EFA83423.1 - 0.022 14.8 0.9 0.022 14.8 0.9 3.1 2 1 1 3 3 2 0 ECF-type riboflavin transporter, S component SRP54 PF00448.22 EFA83423.1 - 0.024 14.3 1.3 0.77 9.4 1.2 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 EFA83423.1 - 0.028 14.8 1.6 1.6 9.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFA83423.1 - 0.034 13.7 3.3 2 8.0 0.4 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 EFA83423.1 - 0.034 13.9 0.5 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MobB PF03205.14 EFA83423.1 - 0.038 13.9 0.4 0.83 9.5 0.1 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B G-alpha PF00503.20 EFA83423.1 - 0.072 12.2 2.5 0.92 8.6 0.8 2.6 2 1 0 2 2 2 0 G-protein alpha subunit T2SSE PF00437.20 EFA83423.1 - 0.073 12.1 0.1 2.4 7.2 0.0 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein MeaB PF03308.16 EFA83423.1 - 0.086 11.8 0.1 2 7.3 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Mg_chelatase PF01078.21 EFA83423.1 - 0.14 11.5 3.4 0.54 9.6 0.4 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF87 PF01935.17 EFA83423.1 - 0.14 12.2 0.6 15 5.6 0.1 2.7 2 1 0 2 2 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 EFA83423.1 - 0.19 12.0 0.1 3.5 7.9 0.0 2.9 3 0 0 3 3 2 0 Putative exonuclease SbcCD, C subunit Guanylate_kin PF00625.21 EFA83423.1 - 0.43 10.3 2.0 27 4.4 0.1 2.8 2 1 1 3 3 3 0 Guanylate kinase FAD_binding_3 PF01494.19 EFA83424.1 - 5.8e-21 75.1 0.2 5.4e-12 45.6 0.1 2.7 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EFA83424.1 - 1.8e-05 24.1 1.6 0.041 13.1 0.2 2.4 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFA83424.1 - 0.00042 20.5 0.0 0.00089 19.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EFA83424.1 - 0.0063 15.4 0.1 0.025 13.4 0.0 2.0 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox PF00070.27 EFA83424.1 - 0.012 16.1 0.2 0.16 12.5 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA83424.1 - 0.017 14.8 0.4 0.069 12.7 0.0 2.0 2 1 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFA83424.1 - 0.022 14.0 0.0 0.12 11.6 0.0 2.1 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFA83424.1 - 0.036 13.1 0.0 0.075 12.1 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 EFA83424.1 - 0.055 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFA83425.1 - 1.5e-17 63.9 0.3 5.9e-07 29.1 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain Pyr_redox_2 PF07992.14 EFA83425.1 - 1.5e-05 24.3 0.0 0.02 14.1 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA83425.1 - 0.00062 20.3 0.1 0.091 13.3 0.3 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFA83425.1 - 0.00073 19.7 0.3 0.0019 18.4 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA83425.1 - 0.02 14.5 0.0 0.038 13.6 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EFA83425.1 - 0.028 13.3 1.7 0.031 13.1 0.3 1.7 2 1 1 3 3 3 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EFA83425.1 - 0.037 13.3 0.4 6.5 5.9 0.9 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFA83425.1 - 0.095 11.8 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Lipase_3 PF01764.25 EFA83427.1 - 3.5e-30 104.7 0.0 4.8e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EFA83427.1 - 0.0016 19.1 0.0 0.002 18.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 EFA83427.1 - 0.0055 16.3 0.0 0.012 15.2 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_8 PF06259.12 EFA83427.1 - 0.008 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase PGAP1 PF07819.13 EFA83427.1 - 0.012 15.3 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Tmemb_55A PF09788.9 EFA83427.1 - 0.025 13.7 0.0 0.046 12.8 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 55A LRR_6 PF13516.6 EFA83428.1 - 4.8e-19 66.7 27.3 0.0071 16.3 0.1 9.1 9 0 0 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.33 EFA83428.1 - 3.9e-05 23.6 27.4 0.89 10.3 0.2 8.7 8 0 0 8 8 8 3 Leucine Rich Repeat LRR_4 PF12799.7 EFA83428.1 - 0.0031 17.9 1.2 0.0031 17.9 1.2 6.5 2 2 6 8 8 8 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA83428.1 - 0.64 9.8 32.6 0.075 12.8 4.4 7.2 4 1 2 6 6 6 0 Leucine rich repeat DUF2971 PF11185.8 EFA83428.1 - 9 7.5 8.5 30 5.9 8.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2971) zf-B_box PF00643.24 EFA83429.1 - 2.2e-06 27.7 9.4 5.9e-06 26.3 9.4 1.7 1 0 0 1 1 1 1 B-box zinc finger Tropomyosin_1 PF12718.7 EFA83429.1 - 0.025 14.7 2.6 0.055 13.6 2.6 1.5 1 0 0 1 1 1 0 Tropomyosin like RPW8 PF05659.11 EFA83429.1 - 0.047 13.4 0.9 0.15 11.8 0.9 1.8 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4457 PF14652.6 EFA83430.1 - 3.9e-133 443.7 22.4 1.7e-124 415.3 1.5 5.3 4 1 1 5 5 5 3 Domain of unknown function (DUF4457) Sad1_UNC PF07738.13 EFA83430.1 - 4.4e-05 23.5 0.2 0.28 11.2 0.0 3.4 3 0 0 3 3 3 2 Sad1 / UNC-like C-terminal GCK PF07802.11 EFA83431.1 - 0.0016 18.8 0.2 0.0025 18.2 0.2 1.2 1 0 0 1 1 1 1 GCK domain CHCH PF06747.13 EFA83431.1 - 0.053 13.7 1.1 0.082 13.1 1.1 1.3 1 0 0 1 1 1 0 CHCH domain Fumble PF03630.14 EFA83432.1 - 5.3e-129 430.1 3.6 9.1e-129 429.4 3.6 1.4 1 0 0 1 1 1 1 Fumble GTP_EFTU PF00009.27 EFA83433.1 - 3.2e-45 154.0 0.2 3.2e-45 154.0 0.2 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFA83433.1 - 2.7e-25 88.8 0.2 7e-25 87.5 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFA83433.1 - 3.1e-06 27.5 0.7 1e-05 25.8 0.3 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFA83433.1 - 7.4e-05 22.8 0.4 0.00082 19.4 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFA83433.1 - 0.024 13.8 0.0 0.12 11.5 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit HNF-1_N PF04814.13 EFA83433.1 - 0.024 15.2 1.2 0.05 14.2 1.2 1.5 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF2225 PF09986.9 EFA83433.1 - 0.062 13.0 0.1 9.9 5.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) ORC6 PF05460.13 EFA83433.1 - 0.13 11.5 3.7 0.2 10.9 3.7 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PAM2 PF07145.15 EFA83433.1 - 0.44 10.3 4.3 0.11 12.2 0.9 1.9 2 0 0 2 2 2 0 Ataxin-2 C-terminal region Dicty_REP PF05086.12 EFA83433.1 - 0.75 7.7 4.3 1.1 7.2 4.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DEC-1_N PF04625.13 EFA83433.1 - 2.8 6.9 14.5 5.1 6.0 14.5 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region FtsL PF04999.13 EFA83434.1 - 0.0066 16.4 0.1 0.013 15.5 0.1 1.4 1 0 0 1 1 1 1 Cell division protein FtsL TMEM154 PF15102.6 EFA83434.1 - 0.022 14.7 0.5 0.039 13.9 0.1 1.6 2 0 0 2 2 2 0 TMEM154 protein family MLANA PF14991.6 EFA83434.1 - 0.084 13.2 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein melan-A Tetraspanin PF00335.20 EFA83434.1 - 0.51 10.0 8.3 0.74 9.5 8.3 1.4 1 1 0 1 1 1 0 Tetraspanin family Lipase_3 PF01764.25 EFA83435.1 - 1.7e-31 109.0 0.0 2.4e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EFA83435.1 - 0.0041 16.4 0.0 0.0064 15.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 EFA83435.1 - 0.032 13.9 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Cutinase PF01083.22 EFA83435.1 - 0.058 13.4 0.9 0.2 11.6 0.9 1.9 1 1 0 1 1 1 0 Cutinase Abhydrolase_6 PF12697.7 EFA83435.1 - 0.092 13.3 0.0 0.13 12.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family SWIRM PF04433.17 EFA83436.1 - 1.5e-29 102.2 0.2 4.1e-29 100.8 0.2 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EFA83436.1 - 2.3e-21 75.5 2.5 2.3e-21 75.5 2.5 2.3 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EFA83436.1 - 1.1e-10 41.6 0.0 2e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA83436.1 - 3.6e-06 27.1 0.0 1.4e-05 25.3 0.0 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_3 PF16498.5 EFA83436.1 - 0.0091 16.2 0.5 0.0091 16.2 0.5 2.8 3 0 0 3 3 3 1 SWIRM-associated domain at the C-terminal NiFe-hyd_HybE PF11939.8 EFA83436.1 - 0.01 15.7 1.1 2.7 7.9 0.1 2.7 2 0 0 2 2 2 0 [NiFe]-hydrogenase assembly, chaperone, HybE HHH_4 PF14490.6 EFA83436.1 - 0.046 13.7 0.1 0.14 12.1 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix containing domain Menin PF05053.13 EFA83437.1 - 2.3 6.5 7.1 2.8 6.2 7.1 1.0 1 0 0 1 1 1 0 Menin GalKase_gal_bdg PF10509.9 EFA83438.1 - 1e-20 73.0 0.1 1.9e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 EFA83438.1 - 1.6e-14 54.0 0.0 5.5e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EFA83438.1 - 4.8e-11 42.7 0.2 1.3e-10 41.3 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain SH3_9 PF14604.6 EFA83439.1 - 1.2e-06 28.3 0.1 2.7e-06 27.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA83439.1 - 5.5e-06 25.9 1.4 9.4e-06 25.1 0.1 2.1 2 1 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EFA83439.1 - 3.6e-05 23.4 0.0 8.6e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain CS PF04969.16 EFA83439.1 - 0.0013 19.7 0.1 0.0064 17.5 0.1 2.3 2 1 0 2 2 2 1 CS domain Glutaminase PF04960.15 EFA83440.1 - 1.5e-19 70.2 0.6 2.6e-19 69.5 0.6 1.2 1 0 0 1 1 1 1 Glutaminase SH3_1 PF00018.28 EFA83440.1 - 5.6e-13 48.3 0.1 9.1e-13 47.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA83440.1 - 1.1e-12 47.4 0.1 1.8e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFA83440.1 - 1.6e-09 37.4 0.1 2.7e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain PCEMA1 PF07418.11 EFA83440.1 - 0.51 9.8 3.8 1.2 8.6 3.8 1.6 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Ras PF00071.22 EFA83441.1 - 2.9e-52 176.5 0.0 3.7e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA83441.1 - 1.3e-23 83.5 0.0 2.4e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83441.1 - 2e-11 43.7 0.0 2.7e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA83441.1 - 7.3e-06 25.7 0.1 4.3e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA83441.1 - 0.0081 16.2 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA83441.1 - 0.13 11.7 2.2 0.63 9.4 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit SR-25 PF10500.9 EFA83441.1 - 0.18 11.4 25.8 0.32 10.6 25.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SSP160 PF06933.11 EFA83441.1 - 0.29 9.3 17.6 0.37 8.9 17.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Herpes_pp85 PF04637.12 EFA83441.1 - 0.32 9.4 9.0 0.41 9.0 9.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Macoilin PF09726.9 EFA83441.1 - 0.44 9.1 12.2 0.45 9.0 12.2 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EFA83441.1 - 0.78 8.5 10.7 0.92 8.3 10.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Menin PF05053.13 EFA83441.1 - 0.8 8.0 6.5 0.88 7.9 6.5 1.1 1 0 0 1 1 1 0 Menin Bul1_C PF04426.12 EFA83441.1 - 0.96 8.8 6.2 1.7 8.0 6.2 1.3 1 0 0 1 1 1 0 Bul1 C terminus Sec3_C PF09763.9 EFA83441.1 - 1.5 7.1 6.0 1.7 6.9 6.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Herpes_capsid PF06112.11 EFA83441.1 - 2.1 8.4 16.7 3.1 7.8 16.7 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein RSRP PF17069.5 EFA83441.1 - 6.9 6.2 21.4 10 5.6 21.4 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 CCDC106 PF15794.5 EFA83441.1 - 7.6 6.2 16.8 11 5.7 16.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 FNIP PF05725.12 EFA83442.1 - 2.1e-87 287.1 55.9 1.4e-13 50.7 0.2 9.7 5 1 6 11 11 11 11 FNIP Repeat DUF1769 PF08588.10 EFA83442.1 - 2.2e-09 37.4 13.4 0.5 10.6 0.0 8.7 5 1 4 9 9 9 4 Protein of unknown function (DUF1769) zf-B_box PF00643.24 EFA83443.1 - 8.6e-05 22.6 11.5 0.00022 21.3 11.5 1.7 1 0 0 1 1 1 1 B-box zinc finger RP-C_C PF11800.8 EFA83443.1 - 0.0018 18.4 1.3 0.0029 17.7 1.3 1.4 1 0 0 1 1 1 1 Replication protein C C-terminal region RPW8 PF05659.11 EFA83443.1 - 0.0061 16.2 2.5 0.0086 15.8 1.1 2.0 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 Tropomyosin_1 PF12718.7 EFA83443.1 - 0.024 14.8 1.6 0.054 13.7 1.6 1.5 1 0 0 1 1 1 0 Tropomyosin like Kelch_6 PF13964.6 EFA83443.1 - 0.031 14.6 1.3 1.2 9.5 0.1 3.7 3 1 0 3 3 3 0 Kelch motif BLOC1_2 PF10046.9 EFA83443.1 - 0.035 14.4 2.0 0.44 10.9 0.2 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF241 PF03087.14 EFA83443.1 - 0.036 13.9 2.2 0.065 13.1 0.2 2.1 2 0 0 2 2 2 0 Arabidopsis protein of unknown function Prefoldin_2 PF01920.20 EFA83443.1 - 0.077 13.0 6.4 0.027 14.4 3.4 1.8 2 0 0 2 2 2 0 Prefoldin subunit Kelch_1 PF01344.25 EFA83443.1 - 0.16 11.6 0.1 1.1 8.9 0.1 2.5 1 1 0 1 1 1 0 Kelch motif DUF4988 PF16378.5 EFA83443.1 - 5.5 6.6 8.0 0.36 10.5 1.3 2.4 3 0 0 3 3 3 0 Domain of unknown function Kelch_6 PF13964.6 EFA83444.1 - 1.5e-07 31.5 4.1 0.00071 19.8 0.0 4.8 4 1 1 5 5 5 1 Kelch motif PQQ_3 PF13570.6 EFA83444.1 - 0.015 15.8 0.0 16 6.1 0.0 3.4 2 1 1 3 3 3 0 PQQ-like domain Kelch_1 PF01344.25 EFA83444.1 - 0.41 10.3 3.4 2 8.0 0.0 3.7 5 0 0 5 5 5 0 Kelch motif zf-B_box PF00643.24 EFA83445.1 - 1.1e-05 25.4 11.9 3e-05 24.1 11.9 1.7 1 0 0 1 1 1 1 B-box zinc finger RP-C_C PF11800.8 EFA83445.1 - 0.0005 20.2 1.3 0.00063 19.9 1.3 1.1 1 0 0 1 1 1 1 Replication protein C C-terminal region Tropomyosin_1 PF12718.7 EFA83445.1 - 0.00059 20.0 1.4 0.00059 20.0 1.4 1.8 2 0 0 2 2 2 1 Tropomyosin like RPW8 PF05659.11 EFA83445.1 - 0.0011 18.6 0.9 0.0026 17.4 0.9 1.6 1 0 0 1 1 1 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4988 PF16378.5 EFA83445.1 - 0.036 13.7 0.7 0.057 13.1 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function XhlA PF10779.9 EFA83445.1 - 0.043 14.0 0.4 0.043 14.0 0.4 2.1 2 0 0 2 2 2 0 Haemolysin XhlA Syntaxin PF00804.25 EFA83445.1 - 0.062 13.0 2.8 0.082 12.6 2.8 1.3 1 0 0 1 1 1 0 Syntaxin NPV_P10 PF05531.12 EFA83445.1 - 0.067 13.7 0.9 0.15 12.5 0.2 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin-18_N PF10496.9 EFA83445.1 - 0.12 12.6 0.4 0.12 12.6 0.4 2.3 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus MMPL PF03176.15 EFA83445.1 - 0.24 10.3 0.1 0.32 9.9 0.1 1.2 1 0 0 1 1 1 0 MMPL family Prefoldin_2 PF01920.20 EFA83445.1 - 0.43 10.6 6.7 0.066 13.2 2.3 1.8 2 0 0 2 2 2 0 Prefoldin subunit Tup_N PF08581.10 EFA83445.1 - 5.2 7.4 9.0 0.27 11.6 1.5 2.5 3 0 0 3 3 3 0 Tup N-terminal Ribosomal_S18 PF01084.20 EFA83446.1 - 5.3e-15 55.4 0.0 2.1e-14 53.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 NuiA PF07924.11 EFA83446.1 - 0.46 10.9 2.6 0.54 10.6 0.0 2.4 3 0 0 3 3 3 0 Nuclease A inhibitor-like protein Ras PF00071.22 EFA83447.1 - 3.7e-30 104.7 0.8 1.3e-29 102.9 0.8 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA83447.1 - 2.7e-19 69.5 0.1 2e-18 66.7 0.0 2.7 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ERCC4 PF02732.15 EFA83447.1 - 9.4e-10 38.9 1.2 9.4e-10 38.9 1.2 3.6 2 1 2 4 4 4 1 ERCC4 domain MMR_HSR1 PF01926.23 EFA83447.1 - 5e-08 33.0 0.8 2e-07 31.1 0.0 2.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase Arf PF00025.21 EFA83447.1 - 8.3e-05 22.1 0.0 0.00019 21.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 EFA83447.1 - 0.00054 20.4 0.0 0.021 15.2 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain MCM PF00493.23 EFA83447.1 - 0.0031 16.7 0.0 0.0084 15.2 0.0 1.7 1 0 0 1 1 1 1 MCM P-loop domain NPL4 PF05021.15 EFA83448.1 - 5.9e-25 88.3 0.9 8.4e-16 58.2 0.3 3.4 1 1 0 2 2 2 2 NPL4 family UN_NPL4 PF11543.8 EFA83448.1 - 9.1e-07 29.3 0.0 3.3e-06 27.5 0.0 2.0 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 JAB PF01398.21 EFA83448.1 - 1.4e-06 28.3 0.0 3.2e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease FlgH PF02107.16 EFA83448.1 - 0.081 12.5 4.6 0.21 11.2 4.6 1.6 1 0 0 1 1 1 0 Flagellar L-ring protein YukD PF08817.10 EFA83448.1 - 0.14 12.9 0.0 0.29 11.9 0.0 1.6 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Menin PF05053.13 EFA83448.1 - 2.9 6.2 14.4 0.24 9.7 4.5 2.1 2 0 0 2 2 2 0 Menin Utp14 PF04615.13 EFA83449.1 - 0.012 14.3 30.8 0.012 14.3 30.8 1.2 1 0 0 1 1 1 0 Utp14 protein Menin PF05053.13 EFA83449.1 - 1.7 6.9 21.3 2 6.7 21.3 1.3 1 0 0 1 1 1 0 Menin Trypan_PARP PF05887.11 EFA83449.1 - 4.4 7.3 13.4 1.4 8.9 10.5 1.7 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PTPA PF03095.15 EFA83451.1 - 4.1e-82 276.0 0.3 4e-77 259.6 0.0 2.0 1 1 1 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein Nyv1_N PF09426.10 EFA83452.1 - 0.22 11.5 2.9 0.28 11.2 2.9 1.2 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal HMG-CoA_red PF00368.18 EFA83453.1 - 1.2e-149 498.3 1.8 1.5e-149 498.0 1.8 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Herpes_DNAp_acc PF04929.12 EFA83453.1 - 0.41 9.6 4.7 0.68 8.9 4.7 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor WD40 PF00400.32 EFA83454.1 - 1.6e-27 95.1 19.3 9.1e-05 23.2 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83454.1 - 0.0002 21.6 0.1 0.24 11.7 0.0 3.4 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA83454.1 - 0.0018 18.3 0.4 0.16 12.0 0.1 3.7 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region F-box-like PF12937.7 EFA83454.1 - 0.0037 17.1 0.1 0.0071 16.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like WD40_like PF17005.5 EFA83454.1 - 0.092 12.1 13.6 0.1 11.9 1.2 3.3 4 1 0 4 4 4 0 WD40-like domain FAD_binding_2 PF00890.24 EFA83455.1 - 1.8e-125 419.3 2.8 2.4e-125 418.9 2.8 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EFA83455.1 - 3.3e-43 146.7 2.7 9.3e-43 145.3 2.7 1.8 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Chromosome_seg PF13889.6 EFA83455.1 - 1.1e-19 70.3 0.6 3.2e-19 68.8 0.6 1.8 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 EFA83455.1 - 2e-11 44.3 0.0 5.3e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Pyr_redox_2 PF07992.14 EFA83455.1 - 0.0026 17.1 1.9 0.0042 16.3 0.4 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFA83455.1 - 0.0034 16.6 0.2 0.47 9.7 0.1 2.7 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.19 EFA83455.1 - 0.0052 16.1 0.2 0.011 14.9 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFA83455.1 - 0.038 13.6 1.4 0.14 11.7 1.4 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFA83455.1 - 0.081 12.0 10.9 0.14 11.2 1.4 3.0 3 0 0 3 3 3 0 Glucose inhibited division protein A Phage_P2_GpE PF06528.12 EFA83455.1 - 0.15 11.6 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 Phage P2 GpE HI0933_like PF03486.14 EFA83455.1 - 5.2 5.7 10.7 0.73 8.5 0.3 2.6 2 0 0 2 2 2 0 HI0933-like protein OCD_Mu_crystall PF02423.15 EFA83456.1 - 1.3e-57 195.2 0.1 1.6e-57 194.9 0.1 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EFA83456.1 - 5.3e-06 26.5 0.1 8.7e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase B_lectin PF01453.24 EFA83457.1 - 0.0009 19.7 0.2 9.1 6.9 0.0 3.9 3 1 1 4 4 4 3 D-mannose binding lectin ACAS_N PF16177.5 EFA83458.1 - 0.035 14.0 5.0 0.063 13.2 0.4 2.7 2 0 0 2 2 2 0 Acetyl-coenzyme A synthetase N-terminus DUF5086 PF16985.5 EFA83458.1 - 0.066 13.1 0.7 0.26 11.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5086) DSHCT PF08148.12 EFA83459.1 - 1.9e-47 161.0 0.1 1.9e-47 161.0 0.1 2.3 2 0 0 2 2 2 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 EFA83459.1 - 2.5e-33 116.2 0.4 3.7e-32 112.3 0.4 2.6 1 1 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 EFA83459.1 - 1.9e-17 63.6 0.0 5.3e-17 62.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ski2_N PF17911.1 EFA83459.1 - 6e-15 55.2 0.1 6e-15 55.2 0.1 1.9 2 0 0 2 2 2 1 Ski2 N-terminal region Helicase_C PF00271.31 EFA83459.1 - 8.7e-06 26.1 0.0 4.8e-05 23.7 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain BSP_II PF05432.11 EFA83459.1 - 0.0037 17.0 18.4 0.007 16.1 18.4 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DUF4820 PF16091.5 EFA83459.1 - 1.1 8.6 7.8 2.5 7.4 7.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Nop14 PF04147.12 EFA83459.1 - 9.5 4.3 20.5 16 3.5 20.5 1.2 1 0 0 1 1 1 0 Nop14-like family Glyco_trans_2_3 PF13632.6 EFA83461.1 - 8.4e-23 81.3 0.1 8.4e-23 81.3 0.1 2.3 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 EFA83461.1 - 2e-20 72.9 20.3 7.3e-14 51.2 2.2 4.3 4 1 1 5 5 5 3 Cellulose synthase Glyco_tranf_2_3 PF13641.6 EFA83461.1 - 1.1e-16 61.5 0.0 3.6e-16 59.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFA83461.1 - 4.1e-11 43.0 0.0 2.9e-09 37.0 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EFA83461.1 - 1.4e-07 31.2 0.0 2.2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Prp31_C PF09785.9 EFA83461.1 - 0.22 12.5 5.4 0.27 12.2 0.3 2.6 2 0 0 2 2 2 0 Prp31 C terminal domain DUF4407 PF14362.6 EFA83463.1 - 0.0042 16.5 1.7 0.0067 15.8 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF3450 PF11932.8 EFA83463.1 - 0.0077 15.6 8.9 0.42 9.9 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) Sec34 PF04136.15 EFA83463.1 - 0.015 15.2 12.2 0.62 9.9 5.1 2.6 2 0 0 2 2 2 0 Sec34-like family RRM_3 PF08777.11 EFA83463.1 - 0.1 12.6 3.6 0.4 10.7 0.5 2.4 2 0 0 2 2 2 0 RNA binding motif Seryl_tRNA_N PF02403.22 EFA83463.1 - 0.25 11.6 11.7 0.083 13.1 1.3 3.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TSC22 PF01166.18 EFA83463.1 - 0.32 11.3 3.3 0.35 11.2 0.1 2.7 2 1 0 2 2 2 0 TSC-22/dip/bun family zf-C4H2 PF10146.9 EFA83463.1 - 0.72 10.1 9.8 1.4 9.2 9.8 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein bZIP_1 PF00170.21 EFA83463.1 - 1.5 8.9 17.4 4.1 7.6 0.3 3.9 4 0 0 4 4 4 0 bZIP transcription factor CENP-F_leu_zip PF10473.9 EFA83463.1 - 2.5 8.1 20.2 1 9.4 5.6 3.0 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YabA PF06156.13 EFA83463.1 - 6.1 7.5 14.1 0.13 12.9 0.7 3.2 2 1 1 3 3 3 0 Initiation control protein YabA APG6_N PF17675.1 EFA83463.1 - 9.6 6.7 23.9 0.067 13.7 2.0 3.0 1 1 1 3 3 3 0 Apg6 coiled-coil region PNTB PF02233.16 EFA83464.1 - 3.1e-166 553.9 22.4 3.1e-166 553.9 22.4 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EFA83464.1 - 1.1e-70 237.3 1.6 1.1e-70 237.3 1.6 2.8 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EFA83464.1 - 1.8e-44 151.4 0.0 4e-44 150.2 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EFA83464.1 - 4.2e-32 110.4 5.0 4.2e-32 110.4 5.0 4.2 4 1 0 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EFA83464.1 - 7.3e-05 22.2 0.8 0.61 9.4 0.1 3.7 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 EFA83464.1 - 0.00029 20.6 0.4 0.0012 18.5 0.4 2.2 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DUF3392 PF11872.8 EFA83464.1 - 0.082 13.2 1.9 0.4 11.0 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3392) DUF5401 PF17380.2 EFA83464.1 - 0.45 8.5 1.5 0.64 8.0 1.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Peptidase_S13 PF02113.15 EFA83466.1 - 7.4e-63 212.8 0.0 9e-63 212.5 0.0 1.0 1 0 0 1 1 1 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family BTB_2 PF02214.22 EFA83467.1 - 3.8e-14 52.8 0.0 1.1e-13 51.3 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide PF00805.22 EFA83467.1 - 5.1e-13 48.4 4.8 9.2e-07 28.4 0.8 2.6 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFA83467.1 - 1.6e-07 31.4 0.3 1.6e-07 31.4 0.3 2.3 3 0 0 3 3 3 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFA83467.1 - 0.00065 19.8 0.0 0.0028 17.8 0.0 2.2 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Mucin PF01456.17 EFA83467.1 - 2 8.4 12.5 0.55 10.2 3.7 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein HRDC PF00570.23 EFA83468.1 - 4.5e-16 58.6 0.0 8.4e-16 57.7 0.0 1.4 1 0 0 1 1 1 1 HRDC domain RQC PF09382.10 EFA83468.1 - 0.00088 19.0 0.0 0.0022 17.8 0.0 1.7 1 0 0 1 1 1 1 RQC domain TFIIF_alpha PF05793.12 EFA83468.1 - 0.051 12.2 12.8 0.073 11.7 12.8 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 EFA83468.1 - 0.31 10.4 12.0 0.43 9.9 12.0 1.3 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EFA83468.1 - 0.35 10.1 12.0 0.51 9.6 12.0 1.2 1 0 0 1 1 1 0 BUD22 DUF572 PF04502.13 EFA83468.1 - 0.56 9.8 9.4 1.1 8.8 9.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF3439 PF11921.8 EFA83468.1 - 8.8 6.3 12.3 3 7.8 9.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DEAD PF00270.29 EFA83470.1 - 5.1e-17 62.2 0.0 8.5e-15 55.0 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA83470.1 - 0.0021 18.4 1.9 0.005 17.2 0.2 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA83470.1 - 0.037 14.0 0.0 0.16 12.0 0.0 2.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit ColG_sub PF18496.1 EFA83470.1 - 0.095 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Collagenase G catalytic helper subdomain WH2 PF02205.20 EFA83471.1 - 6.4e-12 44.9 0.4 1.8e-11 43.5 0.4 1.9 1 0 0 1 1 1 1 WH2 motif SH3_1 PF00018.28 EFA83471.1 - 1.2e-07 31.3 0.0 1.8e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA83471.1 - 0.00024 20.9 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA83471.1 - 0.0037 16.9 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain HR1 PF02185.16 EFA83471.1 - 0.047 13.8 3.5 0.07 13.3 3.5 1.2 1 0 0 1 1 1 0 Hr1 repeat Pox_A_type_inc PF04508.12 EFA83471.1 - 0.36 10.8 0.8 7.1 6.7 0.1 2.2 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat DSPc PF00782.20 EFA83472.1 - 1.6e-26 92.7 2.1 7.7e-24 84.0 0.0 3.3 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EFA83472.1 - 0.0083 16.4 0.0 0.038 14.3 0.0 2.1 1 0 0 1 1 1 1 Rit1 DUSP-like domain ArsP_1 PF03773.13 EFA83472.1 - 0.26 10.4 0.2 0.59 9.2 0.2 1.5 1 0 0 1 1 1 0 Predicted permease V-SNARE PF05008.15 EFA83473.1 - 5.3e-12 45.9 3.7 5.3e-12 45.9 3.7 2.1 3 0 0 3 3 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EFA83473.1 - 1.2e-11 44.7 1.9 1.2e-11 44.7 1.9 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus SdrD_B PF17210.3 EFA83473.1 - 4e-06 27.0 0.0 1.2e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA83473.1 - 4.1e-05 23.8 0.0 0.00018 21.7 0.0 2.1 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4407 PF14362.6 EFA83473.1 - 0.0036 16.7 5.1 0.0061 16.0 5.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) GIT1_C PF12205.8 EFA83473.1 - 0.018 15.1 0.8 0.044 13.9 0.8 1.6 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Sec20 PF03908.13 EFA83473.1 - 0.05 13.5 2.3 0.16 11.9 0.2 2.7 2 0 0 2 2 2 0 Sec20 CarbopepD_reg_2 PF13715.6 EFA83473.1 - 0.058 13.4 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 CarboxypepD_reg-like domain GCN5L1 PF06320.13 EFA83473.1 - 0.093 12.9 3.4 0.3 11.2 3.0 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) Suppressor_APC PF11414.8 EFA83473.1 - 0.16 12.0 4.0 8.9 6.5 0.1 3.0 2 1 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein E2R135 PF11570.8 EFA83473.1 - 0.25 11.6 3.7 1.2 9.4 1.9 2.4 2 1 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF3573 PF12097.8 EFA83473.1 - 0.3 9.9 2.3 0.49 9.2 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) LRRC37AB_C PF14914.6 EFA83473.1 - 0.31 10.9 3.3 8.7 6.2 0.2 2.7 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain zf-C4H2 PF10146.9 EFA83473.1 - 0.77 10.0 5.9 1.4 9.2 5.9 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein EMC3_TMCO1 PF01956.16 EFA83473.1 - 1.1 9.0 8.0 0.087 12.6 0.6 2.8 3 1 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Laminin_II PF06009.12 EFA83473.1 - 2.6 8.1 6.8 18 5.4 0.1 3.1 1 1 2 3 3 3 0 Laminin Domain II DUF1664 PF07889.12 EFA83473.1 - 3 7.9 6.9 4 7.5 0.9 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 EFA83473.1 - 8.8 5.5 6.8 2.2 7.5 0.7 2.2 1 1 1 2 2 2 0 TMPIT-like protein GNAT_acetyltr_2 PF13718.6 EFA83474.1 - 2.1e-97 325.0 0.9 4.1e-97 324.0 0.0 2.0 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EFA83474.1 - 3.8e-73 246.1 4.8 8.3e-73 244.9 4.8 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EFA83474.1 - 3.6e-36 124.7 0.8 5.2e-33 114.4 0.0 3.6 3 0 0 3 3 3 2 Helicase DUF1726 PF08351.11 EFA83474.1 - 1e-32 111.9 0.7 3.2e-32 110.3 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) Acetyltransf_7 PF13508.7 EFA83474.1 - 0.0024 18.2 0.0 0.0069 16.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA83474.1 - 0.004 17.4 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Anophelin PF10731.9 EFA83474.1 - 0.075 12.9 0.6 0.26 11.2 0.6 1.9 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Tau95 PF09734.9 EFA83475.1 - 0.098 13.5 0.6 0.3 11.9 0.2 2.0 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Ank_2 PF12796.7 EFA83476.1 - 1.2e-23 83.4 3.6 7e-06 26.5 0.1 6.2 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83476.1 - 3.8e-22 78.4 10.8 6.1e-05 23.5 0.7 9.0 5 3 7 12 12 12 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83476.1 - 1.2e-17 63.7 7.0 0.00077 19.7 0.1 9.8 5 3 7 12 12 12 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83476.1 - 2.3e-15 55.2 3.6 0.77 10.5 0.0 11.5 12 2 2 14 14 14 2 Ankyrin repeat Ank PF00023.30 EFA83476.1 - 0.0068 16.8 0.1 49 4.6 0.0 5.8 4 2 0 4 4 4 0 Ankyrin repeat Pkinase PF00069.25 EFA83477.1 - 3.8e-77 259.2 0.1 8.4e-77 258.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83477.1 - 4.8e-40 137.5 0.0 8.9e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EFA83477.1 - 2.6e-06 27.1 0.1 7.2e-06 25.7 0.1 1.8 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EFA83477.1 - 3.7e-06 26.5 0.0 6.6e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like AdenylateSensor PF16579.5 EFA83477.1 - 4.4e-06 27.1 0.2 9.1e-05 22.9 0.2 2.7 1 1 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase RIO1 PF01163.22 EFA83477.1 - 0.0004 20.0 1.6 0.0029 17.2 0.2 2.0 1 1 1 2 2 2 1 RIO1 family APH PF01636.23 EFA83477.1 - 0.0049 16.8 0.1 0.23 11.4 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA83477.1 - 0.015 14.6 0.2 0.039 13.3 0.2 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFA83477.1 - 0.054 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC1 PF03109.16 EFA83477.1 - 0.056 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Tmemb_14 PF03647.13 EFA83478.1 - 3.7e-28 98.1 7.3 5e-28 97.7 7.3 1.2 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF4064 PF13273.6 EFA83478.1 - 0.028 14.7 2.0 0.032 14.5 1.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) Methyltr_RsmB-F PF01189.17 EFA83479.1 - 6.7e-45 153.2 0.0 1.2e-44 152.4 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EFA83479.1 - 3.1e-08 33.6 1.5 2.1e-07 30.9 0.0 2.7 3 1 1 4 4 4 1 Methyltransferase domain FtsJ PF01728.19 EFA83479.1 - 9.6e-08 32.3 0.1 2.2e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 FtsJ-like methyltransferase K1377 PF15352.6 EFA83479.1 - 0.0006 18.2 3.3 0.00083 17.8 3.3 1.1 1 0 0 1 1 1 1 Susceptibility to monomelic amyotrophy PCMT PF01135.19 EFA83479.1 - 0.0017 18.2 0.1 0.0086 15.8 0.0 2.2 3 0 0 3 3 3 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EFA83479.1 - 0.0028 18.7 0.0 0.023 15.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EFA83479.1 - 0.0037 16.9 0.0 0.88 9.1 0.0 3.0 3 0 0 3 3 3 1 RNA cap guanine-N2 methyltransferase Ubie_methyltran PF01209.18 EFA83479.1 - 0.005 16.2 0.4 0.048 13.0 0.0 2.6 4 0 0 4 4 4 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 EFA83479.1 - 0.0083 15.8 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical protein 95 DUF2431 PF10354.9 EFA83479.1 - 0.055 13.7 0.2 0.34 11.2 0.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF2431) Rad60-SLD PF11976.8 EFA83479.1 - 0.091 12.6 1.2 0.25 11.2 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like ANAPC4_WD40 PF12894.7 EFA83480.1 - 2.6e-08 34.0 1.0 2.8 8.3 0.0 5.3 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA83480.1 - 1.8e-07 31.7 0.3 0.00072 20.3 0.0 4.1 5 0 0 5 5 4 1 WD domain, G-beta repeat WD40_like PF17005.5 EFA83480.1 - 7.8e-05 22.1 0.2 0.16 11.3 0.1 2.4 2 0 0 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 EFA83480.1 - 0.006 16.6 6.2 0.96 9.5 0.0 4.0 2 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EFA83480.1 - 0.0073 15.0 0.0 0.095 11.3 0.0 2.5 2 1 0 3 3 3 1 Nucleoporin Nup120/160 Carbpep_Y_N PF05388.11 EFA83480.1 - 0.022 15.3 0.6 0.068 13.7 0.3 1.9 2 0 0 2 2 2 0 Carboxypeptidase Y pro-peptide CNDH2_C PF16858.5 EFA83480.1 - 0.094 12.6 17.1 0.17 11.7 17.1 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term FliO PF04347.13 EFA83480.1 - 0.18 12.1 0.6 0.93 9.8 0.1 2.3 2 0 0 2 2 2 0 Flagellar biosynthesis protein, FliO BUD22 PF09073.10 EFA83480.1 - 0.77 9.0 30.4 1.3 8.3 30.4 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EFA83480.1 - 3.6 5.7 29.6 8.8 4.5 29.6 1.5 1 1 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFA83480.1 - 6 4.9 36.4 8.4 4.5 36.4 1.1 1 0 0 1 1 1 0 Nop14-like family REPA_OB_2 PF16900.5 EFA83481.1 - 1.2e-05 25.1 0.6 1.2e-05 25.1 0.6 2.8 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EFA83481.1 - 1.6e-05 24.8 1.3 0.00017 21.5 0.2 2.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain POT1 PF02765.17 EFA83481.1 - 0.003 17.4 0.2 0.003 17.4 0.2 3.5 3 1 0 3 3 3 1 Telomeric single stranded DNA binding POT1/CDC13 SAP PF02037.27 EFA83481.1 - 0.0059 16.3 1.6 0.011 15.5 0.2 2.2 2 0 0 2 2 2 1 SAP domain Pkinase PF00069.25 EFA83482.1 - 1e-64 218.4 0.0 1e-64 218.4 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83482.1 - 1.7e-47 161.9 0.0 4.6e-47 160.5 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Proteasome PF00227.26 EFA83482.1 - 2.3e-31 108.8 0.0 6.3e-31 107.3 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit PBD PF00786.28 EFA83482.1 - 9.1e-09 35.5 0.4 9.1e-09 35.5 0.4 3.2 2 0 0 2 2 2 1 P21-Rho-binding domain C1_1 PF00130.22 EFA83482.1 - 8e-08 32.0 12.3 1.6e-07 31.1 12.3 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SBF2 PF12335.8 EFA83482.1 - 2.4e-07 30.6 0.5 2.4e-07 30.6 0.5 3.8 4 0 0 4 4 4 1 Myotubularin protein Acetyltransf_CG PF14542.6 EFA83482.1 - 0.1 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase NOA36 PF06524.12 EFA83486.1 - 0.18 11.1 4.9 0.16 11.2 4.9 1.1 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EFA83486.1 - 0.2 11.4 5.8 0.17 11.6 5.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein VPS9 PF02204.18 EFA83487.1 - 1.1e-10 41.6 0.1 2.2e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain BRCT_2 PF16589.5 EFA83490.1 - 0.0091 16.4 0.0 0.0091 16.4 0.0 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain YabA PF06156.13 EFA83491.1 - 0.0073 16.9 13.5 0.0073 16.9 13.5 4.8 1 1 3 4 4 4 1 Initiation control protein YabA Pex14_N PF04695.13 EFA83491.1 - 0.029 15.0 4.1 0.029 15.0 4.1 4.0 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_L29 PF00831.23 EFA83491.1 - 0.061 13.3 0.5 0.061 13.3 0.5 3.9 3 2 0 3 3 3 0 Ribosomal L29 protein CCDC154 PF15450.6 EFA83491.1 - 1 7.8 41.0 0.32 9.5 36.9 2.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 154 HOOK PF05622.12 EFA83491.1 - 3.2 5.8 47.0 4.5 5.3 45.9 1.7 1 1 0 1 1 1 0 HOOK protein ZapB PF06005.12 EFA83491.1 - 3.3 8.2 51.8 24 5.5 26.9 5.1 2 1 1 3 3 3 0 Cell division protein ZapB APG6_N PF17675.1 EFA83491.1 - 5.6 7.5 44.7 0.56 10.7 4.2 3.4 2 1 1 3 3 3 0 Apg6 coiled-coil region FOXP-CC PF16159.5 EFA83492.1 - 0.002 18.7 4.3 0.021 15.4 0.3 9.8 9 3 2 11 11 11 4 FOXP coiled-coil domain TRM13 PF05206.14 EFA83494.1 - 3.8e-64 216.7 13.4 3.8e-64 216.7 13.4 3.0 2 1 0 2 2 2 1 Methyltransferase TRM13 zf-U11-48K PF05253.12 EFA83494.1 - 7.3e-09 35.4 2.7 1.8e-08 34.1 2.7 1.8 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger zf-TRM13_CCCH PF11722.8 EFA83494.1 - 0.001 18.7 4.2 0.001 18.7 4.2 2.5 3 0 0 3 3 3 1 CCCH zinc finger in TRM13 protein Methyltransf_31 PF13847.6 EFA83494.1 - 0.026 14.3 1.4 0.073 12.9 0.8 2.1 2 0 0 2 2 2 0 Methyltransferase domain CPSF100_C PF13299.6 EFA83494.1 - 0.11 12.7 8.6 0.13 12.5 0.6 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TFIIF_alpha PF05793.12 EFA83494.1 - 0.24 9.9 25.9 0.73 8.4 7.6 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 EFA83494.1 - 3.4 6.3 9.2 1.1 8.0 0.9 2.1 2 0 0 2 2 2 0 Presenilin Auxin_canalis PF05703.11 EFA83494.1 - 4.3 7.2 6.1 21 4.9 2.0 2.5 2 0 0 2 2 2 0 Auxin canalisation DUF5523 PF17661.1 EFA83494.1 - 4.8 6.8 19.2 3.8 7.1 3.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Folliculin PF11704.8 EFA83494.1 - 7.1 6.5 8.2 0.54 10.1 1.4 2.3 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport HATPase_c PF02518.26 EFA83495.1 - 8.1e-29 100.4 0.4 1.9e-28 99.2 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFA83495.1 - 4.2e-23 81.6 0.1 1.1e-22 80.3 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain DHHC PF01529.20 EFA83495.1 - 2.3e-15 56.9 1.3 5.5e-15 55.7 0.2 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase PAS_8 PF13188.7 EFA83495.1 - 4.1e-08 33.1 0.0 0.12 12.5 0.0 4.3 4 0 0 4 4 4 2 PAS domain HisKA PF00512.25 EFA83495.1 - 1.5e-07 31.3 0.5 4e-07 30.0 0.1 2.0 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 EFA83495.1 - 3.7e-07 30.1 0.0 0.0094 15.9 0.0 3.9 4 0 0 4 4 4 2 PAS fold PAS_9 PF13426.7 EFA83495.1 - 6.2e-05 23.2 0.4 0.051 13.8 0.2 4.3 2 1 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EFA83495.1 - 0.0028 17.9 0.0 1.3 9.4 0.0 3.4 3 0 0 3 3 3 1 PAS fold SpoIIIAH PF12685.7 EFA83495.1 - 0.011 15.5 18.1 0.38 10.6 3.3 3.7 3 0 0 3 3 3 0 SpoIIIAH-like protein SID-1_RNA_chan PF13965.6 EFA83495.1 - 0.082 11.3 12.5 0.29 9.5 1.1 3.2 2 1 0 3 3 3 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 EFA83495.1 - 0.092 13.7 16.6 48 5.0 0.0 5.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Nop14 PF04147.12 EFA83495.1 - 0.17 10.1 9.9 1.3 7.1 4.3 2.5 2 0 0 2 2 2 0 Nop14-like family OAD_gamma PF04277.13 EFA83495.1 - 0.81 10.3 2.3 28 5.4 2.6 3.1 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Connexin PF00029.19 EFA83495.1 - 0.95 9.2 4.8 6 6.6 0.0 3.3 3 0 0 3 3 3 0 Connexin Afi1 PF07792.12 EFA83495.1 - 1.6 9.2 25.4 7 7.1 0.4 4.0 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Pex14_N PF04695.13 EFA83495.1 - 2 9.0 6.6 10 6.8 0.0 3.2 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAD_binding_1 PF00667.20 EFA83496.1 - 1.9e-62 210.8 0.0 5.4e-62 209.3 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 EFA83496.1 - 1.6e-30 106.2 0.0 3.1e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFA83496.1 - 2.1e-15 57.3 0.0 5e-15 56.1 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF2685 PF10886.8 EFA83496.1 - 0.085 13.1 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2685) RT_RNaseH_2 PF17919.1 EFA83497.1 - 4.9e-21 74.6 0.0 1.2e-20 73.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA83497.1 - 5e-20 71.7 0.0 1.5e-19 70.2 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Chromo PF00385.24 EFA83497.1 - 3.2e-10 39.7 1.8 1.4e-09 37.7 1.8 2.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EFA83497.1 - 4e-10 39.9 0.0 2.8e-09 37.2 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 EFA83497.1 - 1.6e-08 34.4 0.0 4.9e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRANC PF09372.10 EFA83497.1 - 0.029 14.7 7.2 0.059 13.7 0.4 4.1 2 1 1 3 3 3 0 PRANC domain DUF4805 PF16063.5 EFA83497.1 - 0.045 13.1 0.0 0.045 13.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) zf-CCHC PF00098.23 EFA83497.1 - 0.37 11.0 1.5 0.73 10.0 1.5 1.5 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.6 EFA83500.1 - 5.4e-05 23.8 0.1 0.0003 21.4 0.0 2.4 2 0 0 2 2 2 1 Aspartyl protease Retrotrans_gag PF03732.17 EFA83500.1 - 0.00011 22.4 0.1 0.00011 22.4 0.1 2.5 3 0 0 3 3 3 1 Retrotransposon gag protein gag-asp_proteas PF13975.6 EFA83500.1 - 0.027 15.0 1.0 0.14 12.7 0.0 2.8 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease Helicase_RecD PF05127.14 EFA83500.1 - 0.064 13.1 0.5 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 Helicase Agenet PF05641.12 EFA83501.1 - 0.0065 16.9 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 Agenet domain LBR_tudor PF09465.10 EFA83501.1 - 0.038 13.8 0.1 0.087 12.6 0.1 1.6 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain PCB_OB PF17092.5 EFA83501.1 - 0.16 12.7 0.0 0.32 11.8 0.0 1.4 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain Cornifin PF02389.15 EFA83504.1 - 9.9e-05 22.5 11.5 0.00016 21.9 11.5 1.2 1 0 0 1 1 1 1 Cornifin (SPRR) family RabGAP-TBC PF00566.18 EFA83505.1 - 2.2e-37 128.8 1.1 3.3e-37 128.2 1.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FNIP PF05725.12 EFA83506.1 - 5.1e-23 81.0 24.7 5.7e-07 29.6 0.1 6.5 7 0 0 7 7 7 4 FNIP Repeat F-box PF00646.33 EFA83506.1 - 0.012 15.4 0.1 0.012 15.4 0.1 2.8 3 0 0 3 3 3 0 F-box domain F-box-like PF12937.7 EFA83506.1 - 0.056 13.4 0.9 0.31 11.0 0.1 2.7 2 0 0 2 2 2 0 F-box-like 4HBT_2 PF13279.6 EFA83506.1 - 0.16 12.5 0.5 0.35 11.4 0.5 1.6 1 0 0 1 1 1 0 Thioesterase-like superfamily Kelch_6 PF13964.6 EFA83507.1 - 4.9e-11 42.5 12.2 2.3e-06 27.6 0.1 4.9 5 1 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFA83507.1 - 0.0023 17.5 0.1 0.0023 17.5 0.1 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 EFA83507.1 - 0.24 11.4 2.0 33 4.6 0.1 4.1 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA83507.1 - 0.68 10.3 4.8 14 6.1 0.0 4.1 3 1 0 3 3 3 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA83508.1 - 1.5e-06 28.2 11.3 2.5e-06 27.5 11.3 1.3 1 0 0 1 1 1 1 B-box zinc finger DUF5502 PF17606.2 EFA83508.1 - 0.052 14.2 2.2 0.052 14.2 2.2 2.3 2 1 1 3 3 3 0 Family of unknown function (DUF5502) YcaO_C PF18381.1 EFA83508.1 - 0.087 12.7 3.6 0.15 11.9 3.6 1.4 1 0 0 1 1 1 0 YcaO cyclodehydratase C-terminal domain DUF4451 PF14616.6 EFA83508.1 - 0.21 11.8 5.7 0.77 10.0 5.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) Tnp_zf-ribbon_2 PF13842.6 EFA83508.1 - 2 9.3 5.7 4.5 8.2 5.7 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon DFP PF04127.15 EFA83509.1 - 2.2e-18 66.7 0.0 4.5e-10 39.7 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein RabGAP-TBC PF00566.18 EFA83510.1 - 2.8e-21 76.2 8.3 3.9e-17 62.6 0.7 3.5 3 2 0 3 3 3 2 Rab-GTPase-TBC domain RRM_1 PF00076.22 EFA83511.1 - 3.3e-48 161.4 0.1 4e-21 74.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA83511.1 - 2.6e-06 27.2 0.0 0.005 16.7 0.0 3.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EFA83511.1 - 7.6e-05 22.8 0.0 0.11 12.7 0.0 3.0 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 EFA83511.1 - 0.0057 16.2 0.0 5.1 6.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 EFA83511.1 - 0.097 12.3 0.1 0.28 10.8 0.1 1.8 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Alpha_kinase PF02816.18 EFA83512.1 - 1.1e-47 162.5 0.2 1.3e-47 162.3 0.2 1.1 1 0 0 1 1 1 1 Alpha-kinase family DUF3510 PF12022.8 EFA83512.1 - 0.19 12.1 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) TIG PF01833.24 EFA83513.1 - 4e-65 215.9 79.2 2.8e-11 43.3 0.6 12.6 12 0 0 12 12 12 12 IPT/TIG domain DNase_II PF03265.15 EFA83513.1 - 5.6e-37 127.7 0.0 1.1e-23 84.0 1.5 2.4 2 0 0 2 2 2 2 Deoxyribonuclease II Kelch_6 PF13964.6 EFA83514.1 - 7.3e-07 29.2 0.8 7.3e-07 29.2 0.8 1.6 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EFA83514.1 - 0.002 18.1 0.3 0.0031 17.5 0.3 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 EFA83514.1 - 0.002 17.7 0.4 0.0033 17.0 0.4 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 EFA83514.1 - 0.0037 17.3 0.4 0.0063 16.5 0.4 1.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA83514.1 - 0.1 12.9 0.3 0.23 11.8 0.3 1.6 1 1 0 1 1 1 0 Galactose oxidase, central domain FumaraseC_C PF10415.9 EFA83516.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 Fumarase C C-terminus YMF19 PF02326.15 EFA83517.1 - 0.06 14.1 0.7 0.07 13.9 0.7 1.1 1 0 0 1 1 1 0 Plant ATP synthase F0 DUF347 PF03988.12 EFA83517.1 - 0.076 13.2 1.5 0.1 12.8 1.5 1.2 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) VWA_2 PF13519.6 EFA83518.1 - 7.2e-12 45.9 0.5 4.6e-11 43.3 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain Rad60-SLD PF11976.8 EFA83518.1 - 0.0064 16.3 0.5 0.015 15.1 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFA83518.1 - 0.1 12.4 1.7 0.23 11.2 1.7 1.6 1 0 0 1 1 1 0 Ubiquitin family THP2 PF09432.10 EFA83519.1 - 0.0082 16.2 2.8 0.0082 16.2 2.8 1.9 2 0 0 2 2 2 1 Tho complex subunit THP2 DUF3038 PF11237.8 EFA83519.1 - 0.027 14.5 0.6 0.046 13.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) WAP PF00095.21 EFA83520.1 - 1.2e-06 28.8 10.3 1.5e-06 28.5 10.3 1.1 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Nodulin_late PF07127.11 EFA83520.1 - 0.23 11.8 10.1 0.14 12.5 0.9 2.2 1 1 1 2 2 2 0 Late nodulin protein WAP PF00095.21 EFA83521.1 - 2.5e-05 24.6 13.1 3.6e-05 24.0 13.1 1.1 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Ank_2 PF12796.7 EFA83522.1 - 2.6e-19 69.6 1.2 3.7e-06 27.4 0.1 4.7 3 2 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83522.1 - 2.2e-10 40.6 1.0 0.4 11.1 0.1 6.3 2 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83522.1 - 2.9e-10 39.5 9.3 0.27 11.9 0.0 8.4 9 1 1 10 10 10 3 Ankyrin repeat Ank_4 PF13637.6 EFA83522.1 - 5.6e-10 39.5 2.9 0.04 14.5 0.0 6.4 3 2 3 7 7 7 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA83522.1 - 0.24 11.9 1.3 1.9e+02 2.7 0.0 4.7 4 1 1 5 5 5 0 Ankyrin repeat LMBR1 PF04791.16 EFA83522.1 - 0.24 10.3 10.3 0.57 9.0 10.3 1.6 1 0 0 1 1 1 0 LMBR1-like membrane protein Dicty_CTDC PF00526.18 EFA83523.1 - 6.4e-10 38.7 25.9 7.2e-06 25.8 0.7 3.1 3 0 0 3 3 3 2 Dictyostelium (slime mold) repeat CorA PF01544.18 EFA83523.1 - 0.0082 15.5 2.2 0.012 14.9 2.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein RhoGEF PF00621.20 EFA83524.1 - 5e-42 144.2 1.3 1.2e-41 143.0 1.3 1.7 1 0 0 1 1 1 1 RhoGEF domain SOG2 PF10428.9 EFA83524.1 - 0.0014 18.0 16.0 0.0019 17.5 16.0 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein PH PF00169.29 EFA83524.1 - 0.0067 16.9 0.0 0.026 15.0 0.0 2.2 1 0 0 1 1 1 1 PH domain IQ PF00612.27 EFA83524.1 - 0.22 11.4 1.2 0.4 10.6 1.2 1.5 1 0 0 1 1 1 0 IQ calmodulin-binding motif Macoilin PF09726.9 EFA83524.1 - 1.1 7.8 15.9 1.5 7.3 15.9 1.2 1 0 0 1 1 1 0 Macoilin family JAB PF01398.21 EFA83526.1 - 2.3e-34 117.9 0.4 5.1e-34 116.8 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFA83526.1 - 3.1e-10 40.5 0.9 6.2e-10 39.5 0.9 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EFA83526.1 - 1.3e-08 34.6 0.0 8.1e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EFA83526.1 - 0.028 14.4 1.0 0.15 12.1 0.0 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) C1_1 PF00130.22 EFA83527.1 - 0.0021 17.9 4.5 0.017 15.0 0.3 2.2 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 EFA83527.1 - 0.0037 17.2 9.1 0.1 12.6 9.1 2.1 1 1 0 1 1 1 1 Double zinc ribbon NinF PF05810.12 EFA83527.1 - 0.024 14.5 1.0 0.14 12.1 0.1 2.1 2 0 0 2 2 2 0 NinF protein zinc_ribbon_2 PF13240.6 EFA83527.1 - 0.064 13.0 6.6 9.8 6.0 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 EFA83527.1 - 0.092 12.4 5.1 1 9.0 0.4 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zf-ribbon_3 PF13248.6 EFA83527.1 - 0.28 10.6 11.7 0.57 9.7 0.3 3.1 3 0 0 3 3 3 0 zinc-ribbon domain Rpr2 PF04032.16 EFA83527.1 - 5.4 7.4 7.1 9.1 6.6 1.2 2.5 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ank_2 PF12796.7 EFA83528.1 - 0.00013 22.4 0.0 0.002 18.7 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA83528.1 - 0.001 19.4 0.2 2.6 8.9 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFA83528.1 - 0.0028 18.2 0.3 8.4 7.1 0.0 4.1 3 1 2 5 5 5 2 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA83528.1 - 0.0056 16.6 2.0 0.57 10.2 0.1 3.8 2 1 1 3 3 3 1 Domain of unknown function (DUF3447) Ank_5 PF13857.6 EFA83528.1 - 0.0062 16.8 0.1 2.9 8.3 0.0 4.5 5 1 1 6 6 6 1 Ankyrin repeats (many copies) DUF4116 PF13475.6 EFA83528.1 - 0.012 15.4 2.4 1.9 8.3 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4116) LisH PF08513.11 EFA83528.1 - 0.2 11.7 1.0 11 6.1 0.1 2.9 2 0 0 2 2 2 0 LisH Cupin_4 PF08007.12 EFA83529.1 - 1.3e-63 215.4 0.0 1.8e-63 215.0 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 EFA83529.1 - 4.2e-09 36.5 0.7 1.9e-07 31.1 0.1 2.7 2 1 0 2 2 2 1 Cupin-like domain Cupin_1 PF00190.22 EFA83529.1 - 0.00011 21.8 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EFA83529.1 - 0.00065 19.4 0.0 0.0099 15.6 0.0 2.7 2 0 0 2 2 2 1 Cupin domain PhyH PF05721.13 EFA83529.1 - 0.13 12.6 0.0 0.93 9.7 0.0 2.2 1 1 1 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) TFIIF_alpha PF05793.12 EFA83529.1 - 0.31 9.6 4.4 0.41 9.2 4.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4589 PF15252.6 EFA83529.1 - 0.4 10.6 3.9 0.69 9.9 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) Tim54 PF11711.8 EFA83529.1 - 1.8 7.2 4.0 2.6 6.7 4.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RhoGEF PF00621.20 EFA83530.1 - 2.1e-47 161.7 2.5 3.5e-47 161.0 2.5 1.4 1 0 0 1 1 1 1 RhoGEF domain PSI PF01437.25 EFA83532.1 - 0.00041 20.8 13.1 0.00086 19.8 13.1 1.6 1 0 0 1 1 1 1 Plexin repeat MLANA PF14991.6 EFA83532.1 - 0.00076 19.7 0.6 0.013 15.8 0.2 2.1 2 0 0 2 2 2 1 Protein melan-A Shisa PF13908.6 EFA83532.1 - 0.002 18.4 8.1 0.002 18.4 8.1 1.4 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Orthoreo_P10 PF07204.11 EFA83532.1 - 0.0027 17.6 3.2 0.0027 17.6 3.2 2.0 1 1 0 2 2 2 1 Orthoreovirus membrane fusion protein p10 FAM163 PF15069.6 EFA83532.1 - 0.011 16.2 2.2 0.025 15.0 0.1 2.0 2 0 0 2 2 2 0 FAM163 family TMEM72 PF16054.5 EFA83532.1 - 0.035 13.8 0.6 0.057 13.1 0.6 1.3 1 0 0 1 1 1 0 Transmembrane protein family 72 EphA2_TM PF14575.6 EFA83532.1 - 0.068 14.1 0.1 0.54 11.2 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain EVC2_like PF12297.8 EFA83532.1 - 0.087 11.5 0.1 0.13 10.9 0.1 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein TMEM132D_C PF15706.5 EFA83532.1 - 0.11 12.3 2.7 0.3 10.9 0.2 2.3 2 1 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term YccF PF03733.13 EFA83532.1 - 2.2 9.1 9.6 0.45 11.3 4.0 2.1 2 0 0 2 2 2 0 Inner membrane component domain Ank_2 PF12796.7 EFA83533.1 - 4.4e-20 72.1 16.9 3.2e-07 30.9 0.0 6.9 2 2 6 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83533.1 - 2e-13 50.5 12.3 0.0035 17.9 0.0 8.1 5 4 6 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83533.1 - 3.8e-12 45.2 6.1 13 6.7 0.0 11.6 9 2 2 11 11 11 1 Ankyrin repeat Ank_5 PF13857.6 EFA83533.1 - 1.8e-11 44.0 8.3 0.23 11.8 0.0 8.8 6 2 4 10 10 10 5 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA83533.1 - 0.0028 17.5 0.0 1.8 8.5 0.1 4.6 3 1 1 4 4 4 1 Domain of unknown function (DUF5049) DUF3368 PF11848.8 EFA83533.1 - 0.11 12.3 0.5 2.4 8.0 0.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) LIM PF00412.22 EFA83534.1 - 1.7e-58 194.7 40.6 1.9e-15 56.9 5.2 4.4 4 0 0 4 4 4 4 LIM domain WSD PF15613.6 EFA83534.1 - 0.28 11.7 0.5 5.7 7.5 0.0 2.7 3 0 0 3 3 3 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif CHDCT2 PF08074.11 EFA83534.1 - 4.3 7.5 9.9 0.18 12.0 1.2 2.7 2 1 2 4 4 4 0 CHDCT2 (NUC038) domain Ank_2 PF12796.7 EFA83535.1 - 6.4e-05 23.5 0.8 0.0066 17.0 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Leuk-A4-hydro_C PF09127.11 EFA83535.1 - 0.019 15.0 0.3 0.14 12.3 0.0 2.6 2 1 0 2 2 2 0 Leukotriene A4 hydrolase, C-terminal Ank_4 PF13637.6 EFA83535.1 - 0.027 15.0 1.0 1.1 9.9 0.0 3.7 4 1 0 4 4 4 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83535.1 - 0.11 12.8 0.2 29 5.1 0.0 3.3 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83536.1 - 0.0004 20.9 0.1 0.0074 16.9 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83536.1 - 0.0039 17.5 0.1 0.42 11.0 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83536.1 - 0.0062 17.0 0.8 18 6.3 0.1 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFA83536.1 - 0.16 12.6 0.4 13 6.5 0.0 3.6 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Vac14_Fab1_bd PF12755.7 EFA83537.1 - 0.6 10.7 3.4 1.3 9.7 0.6 2.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region FNIP PF05725.12 EFA83538.1 - 1.2e-13 51.0 45.2 8.7e-07 29.0 0.2 9.0 10 2 0 10 10 10 4 FNIP Repeat F-box_5 PF18511.1 EFA83538.1 - 4.9e-05 22.8 0.2 0.073 12.7 0.0 2.4 2 0 0 2 2 2 2 F-box rRNA_proc-arch PF13234.6 EFA83539.1 - 2.1e-67 227.9 1.9 2.1e-67 227.9 1.9 1.7 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 EFA83539.1 - 4.6e-50 169.5 0.7 2e-49 167.4 0.0 2.2 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EFA83539.1 - 4.6e-15 55.8 0.0 1.6e-14 54.1 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase NPR3 PF03666.13 EFA83539.1 - 1.4 7.7 11.9 2.5 6.8 11.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ICAP-1_inte_bdg PF10480.9 EFA83539.1 - 2.7 8.0 6.6 4.3 7.3 4.4 2.2 2 0 0 2 2 2 0 Beta-1 integrin binding protein FSA_C PF10479.9 EFA83539.1 - 6.2 4.8 7.9 9.7 4.2 7.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PPR PF01535.20 EFA83540.1 - 1.7e-06 27.9 0.5 6.1 7.3 0.0 6.0 6 0 0 6 6 6 2 PPR repeat TPR_8 PF13181.6 EFA83540.1 - 0.081 13.2 0.0 4.1 7.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR_3 PF13812.6 EFA83540.1 - 0.087 12.9 7.8 5 7.3 0.2 4.8 4 0 0 4 4 4 0 Pentatricopeptide repeat domain ECM11 PF15463.6 EFA83540.1 - 6.1 7.4 7.1 19 5.8 7.1 1.9 1 0 0 1 1 1 0 Extracellular mutant protein 11 BRCT_2 PF16589.5 EFA83541.1 - 4.1e-12 46.3 0.2 4.8e-07 30.1 0.2 3.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA83541.1 - 7e-08 32.8 2.5 0.0013 19.1 0.0 4.0 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFA83541.1 - 9.4e-06 25.4 0.1 9.4e-06 25.4 0.1 5.8 4 4 0 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain DUF3449 PF11931.8 EFA83541.1 - 0.19 11.5 0.0 0.19 11.5 0.0 8.5 2 1 2 4 4 4 0 Domain of unknown function (DUF3449) Kelch_6 PF13964.6 EFA83542.1 - 1.6e-11 44.1 2.0 0.026 14.8 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFA83542.1 - 0.00034 20.5 0.5 0.53 10.4 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFA83542.1 - 1.3 9.1 8.4 5.5 7.1 0.2 4.5 6 1 0 6 6 6 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA83542.1 - 1.8 8.7 6.8 21 5.2 0.1 4.3 4 0 0 4 4 4 0 Kelch motif DUF4813 PF16072.5 EFA83543.1 - 0.6 9.7 5.9 0.81 9.3 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) FNIP PF05725.12 EFA83544.1 - 2.1e-22 79.0 25.4 2.2e-13 50.1 0.0 8.4 8 1 0 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA83544.1 - 9.8e-05 21.8 0.2 0.00019 20.9 0.2 1.4 1 0 0 1 1 1 1 F-box FNIP PF05725.12 EFA83545.1 - 9.3e-22 76.9 96.0 1.9e-07 31.1 0.9 17.0 15 5 1 16 16 16 7 FNIP Repeat F-box_5 PF18511.1 EFA83545.1 - 0.0002 20.8 0.3 0.00059 19.4 0.3 1.7 1 0 0 1 1 1 1 F-box Glyco_hydro_65C PF03633.15 EFA83545.1 - 1.5 8.8 3.5 70 3.5 0.0 4.9 6 0 0 6 6 6 0 Glycosyl hydrolase family 65, C-terminal domain Cnl2_NKP2 PF09447.10 EFA83545.1 - 5 7.3 10.0 47 4.2 0.3 5.2 3 2 1 5 5 5 0 Cnl2/NKP2 family protein FNIP PF05725.12 EFA83546.1 - 2.3e-23 82.1 18.7 9e-10 38.6 0.0 7.2 6 1 1 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA83546.1 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA83546.1 - 0.085 12.8 0.1 0.23 11.4 0.1 1.9 1 0 0 1 1 1 0 F-box-like TP_methylase PF00590.20 EFA83547.1 - 2.2e-22 80.1 0.0 4.5e-22 79.0 0.0 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Cpn60_TCP1 PF00118.24 EFA83548.1 - 3e-148 494.5 6.0 4.3e-148 494.0 6.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PucR PF07905.11 EFA83548.1 - 0.0064 16.8 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Purine catabolism regulatory protein-like family DUF5125 PF17163.4 EFA83548.1 - 0.028 14.6 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5125) DUF356 PF04009.12 EFA83548.1 - 0.078 13.3 0.1 0.77 10.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF356) PrpR_N PF06506.11 EFA83548.1 - 6.9 6.2 7.9 0.48 10.0 0.1 2.9 5 0 0 5 5 5 0 Propionate catabolism activator Ras PF00071.22 EFA83549.1 - 3.8e-47 159.9 0.0 4.6e-47 159.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA83549.1 - 7.8e-21 74.5 0.0 1.1e-20 74.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83549.1 - 7.2e-06 25.6 0.0 9.4e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EFA83549.1 - 0.049 13.4 0.0 9.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EFA83549.1 - 0.067 12.7 0.0 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EFA83549.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase TAXi_N PF14543.6 EFA83550.1 - 6.8e-09 36.2 0.2 2.3e-08 34.5 0.1 1.7 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp PF00026.23 EFA83550.1 - 1.9e-07 30.8 0.1 2.9e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EFA83550.1 - 0.00073 20.1 0.0 0.43 11.3 0.0 2.7 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EFA83550.1 - 0.011 16.3 0.0 3.8 8.1 0.0 3.1 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease DUF3443 PF11925.8 EFA83550.1 - 0.072 11.9 0.0 0.2 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3443) CLP1_P PF16575.5 EFA83551.1 - 1.6e-59 200.8 0.0 2.3e-59 200.3 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 EFA83551.1 - 5.7e-31 107.3 0.0 1.2e-30 106.4 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 EFA83551.1 - 1.8e-26 92.2 0.0 3.6e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_24 PF13479.6 EFA83551.1 - 0.00054 19.7 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFA83551.1 - 0.0019 18.3 0.0 0.004 17.2 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 EFA83551.1 - 0.0089 16.1 0.0 0.026 14.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFA83551.1 - 0.016 15.8 0.0 0.036 14.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EFA83551.1 - 0.041 13.6 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EFA83551.1 - 0.061 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EFA83551.1 - 0.064 13.8 0.1 0.26 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EFA83551.1 - 0.21 10.6 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein EGF_2 PF07974.13 EFA83552.1 - 0.0022 18.3 11.6 0.0022 18.3 11.6 2.0 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EFA83552.1 - 1.6 9.1 10.5 4 7.8 10.5 1.7 1 0 0 1 1 1 0 EGF-like domain Toxin_2 PF00451.19 EFA83552.1 - 1.8 8.9 7.0 4.3 7.7 7.0 1.7 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 Abhydrolase_1 PF00561.20 EFA83554.1 - 2.3e-07 30.7 0.1 5.1e-07 29.6 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFA83554.1 - 3.4e-06 27.8 0.0 3.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BetaGal_dom2 PF10435.9 EFA83554.1 - 0.13 12.0 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Beta-galactosidase, domain 2 6PF2K PF01591.18 EFA83556.1 - 7.6e-65 218.3 0.1 1.2e-64 217.7 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFA83556.1 - 1.2e-20 74.0 3.0 2e-20 73.3 3.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFA83556.1 - 0.00047 20.3 0.0 0.00047 20.3 0.0 2.6 3 2 0 3 3 3 1 AAA domain AIP3 PF03915.13 EFA83556.1 - 0.0025 17.0 0.0 0.0025 17.0 0.0 2.8 2 1 1 3 3 3 1 Actin interacting protein 3 DUF1460 PF07313.12 EFA83556.1 - 0.026 13.9 0.1 0.17 11.2 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1460) KTI12 PF08433.10 EFA83556.1 - 0.062 12.7 0.0 0.062 12.7 0.0 2.1 3 0 0 3 3 3 0 Chromatin associated protein KTI12 Mg_chelatase PF01078.21 EFA83556.1 - 0.13 11.6 0.1 0.46 9.8 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SUIM_assoc PF16619.5 EFA83556.1 - 1.7 8.8 22.7 0.17 12.0 5.6 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ank_2 PF12796.7 EFA83559.1 - 1.8e-23 82.9 15.4 3.9e-07 30.6 0.5 7.9 2 2 7 9 9 9 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83559.1 - 4.7e-20 71.7 5.4 0.0064 17.1 0.3 10.3 9 2 1 10 10 10 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83559.1 - 8.1e-19 67.4 7.6 0.03 14.6 0.0 11.6 8 4 4 12 12 12 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83559.1 - 3.4e-15 54.6 3.6 4.7 8.1 0.0 12.5 14 1 1 15 15 15 2 Ankyrin repeat Vps23_core PF09454.10 EFA83559.1 - 0.018 15.0 2.0 3.7 7.6 0.2 4.0 5 0 0 5 5 5 0 Vps23 core domain NTP_transf_2 PF01909.23 EFA83561.1 - 2.1e-09 37.5 0.0 7.5e-09 35.8 0.0 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EFA83561.1 - 1.3e-08 34.9 2.1 2.6e-08 34.0 0.1 2.7 2 0 0 2 2 2 1 Cid1 family poly A polymerase DNA_pol_B_palm PF14792.6 EFA83561.1 - 0.036 14.3 0.0 0.14 12.3 0.0 2.0 1 0 0 1 1 1 0 DNA polymerase beta palm Polbeta PF18765.1 EFA83561.1 - 0.049 13.7 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Thioredoxin PF00085.20 EFA83562.1 - 2.3e-07 30.7 0.2 0.00031 20.7 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin DUF5505 PF17610.2 EFA83562.1 - 0.024 14.6 3.2 0.032 14.2 1.9 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5505) Asp_decarbox PF02261.16 EFA83562.1 - 0.03 14.3 0.5 0.057 13.4 0.5 1.4 1 0 0 1 1 1 0 Aspartate decarboxylase Phosducin PF02114.16 EFA83562.1 - 0.047 12.6 1.6 0.076 11.9 1.6 1.2 1 0 0 1 1 1 0 Phosducin DUF4012 PF13196.6 EFA83562.1 - 0.058 13.9 0.1 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4012) KH_dom-like PF14714.6 EFA83562.1 - 0.098 13.0 1.3 6.7 7.1 0.1 2.7 2 0 0 2 2 2 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal LCIB_C_CA PF18599.1 EFA83562.1 - 0.19 11.0 2.0 0.31 10.3 2.0 1.2 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases DUF3290 PF11694.8 EFA83562.1 - 0.38 10.7 8.5 0.28 11.2 4.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) G-patch_2 PF12656.7 EFA83563.1 - 6e-22 77.5 0.4 6e-22 77.5 0.4 3.1 2 0 0 2 2 2 1 G-patch domain KN17_SH3 PF18131.1 EFA83563.1 - 2.4e-13 50.0 0.3 6.5e-13 48.6 0.3 1.7 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain KOW PF00467.29 EFA83563.1 - 4.9e-08 32.7 0.7 0.013 15.5 0.0 4.0 3 0 0 3 3 3 2 KOW motif G-patch PF01585.23 EFA83563.1 - 1.8e-06 27.7 1.1 4.2e-06 26.6 1.1 1.7 1 0 0 1 1 1 1 G-patch domain DUF4537 PF15057.6 EFA83563.1 - 0.13 12.3 0.2 0.47 10.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) WD40 PF00400.32 EFA83564.1 - 2.5e-17 62.9 1.4 0.00048 20.9 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83564.1 - 2.9e-06 27.5 0.0 2.6 8.4 0.0 4.4 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA83564.1 - 0.00098 19.1 0.1 0.45 10.6 0.0 3.3 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Marek_SORF3 PF07153.11 EFA83564.1 - 0.078 12.3 0.0 0.12 11.7 0.0 1.4 1 1 0 1 1 1 0 Marek's disease-like virus SORF3 protein Hira PF07569.11 EFA83564.1 - 0.14 11.8 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 TUP1-like enhancer of split PH PF00169.29 EFA83566.1 - 3.8e-10 40.2 1.3 1.1e-09 38.7 1.3 1.8 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EFA83566.1 - 7e-05 22.9 2.0 8.6e-05 22.6 0.5 2.0 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA83566.1 - 8.1e-05 22.8 2.6 0.00018 21.7 2.6 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFA83566.1 - 0.00038 20.8 2.2 0.00038 20.8 2.2 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Utp12 PF04003.12 EFA83566.1 - 0.069 13.5 1.0 1.5 9.2 0.1 2.8 3 0 0 3 3 3 0 Dip2/Utp12 Family DUF956 PF06115.11 EFA83566.1 - 0.26 11.0 4.0 1 9.1 2.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF956) AAA_23 PF13476.6 EFA83566.1 - 3.8 7.9 10.3 0.2 12.1 3.2 2.2 2 1 0 2 2 2 0 AAA domain EF-hand_1 PF00036.32 EFA83567.1 - 1.2e-13 49.6 12.1 2.4e-08 32.9 1.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EFA83567.1 - 5.5e-12 44.6 12.3 5.3e-06 26.0 0.7 4.5 5 1 0 5 5 5 2 EF-hand domain EF-hand_5 PF13202.6 EFA83567.1 - 2.6e-08 33.0 13.0 6.1e-05 22.3 0.1 3.7 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EFA83567.1 - 2.6e-08 34.2 7.3 0.0012 19.3 6.0 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFA83567.1 - 1.7e-06 27.8 16.7 0.00017 21.3 4.2 4.0 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 EFA83567.1 - 0.00091 19.5 0.2 0.0041 17.4 0.2 2.0 1 1 0 1 1 1 1 EF-hand domain TerB PF05099.13 EFA83567.1 - 0.019 14.9 0.7 0.17 11.9 0.1 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB EF-hand_4 PF12763.7 EFA83567.1 - 0.021 14.8 2.7 0.057 13.4 0.6 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DHHA2 PF02833.14 EFA83567.1 - 0.021 15.0 0.6 0.035 14.3 0.6 1.6 1 1 0 1 1 1 0 DHHA2 domain SPARC_Ca_bdg PF10591.9 EFA83567.1 - 0.1 12.9 2.5 0.62 10.4 2.4 2.1 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region MecA_N PF05223.11 EFA83567.1 - 0.15 12.3 2.6 0.18 12.1 0.3 2.1 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain WYL_3 PF18488.1 EFA83567.1 - 0.16 12.3 3.5 0.6 10.5 0.3 2.6 2 0 0 2 2 2 0 WYL domain SANT_DAMP1_like PF16282.5 EFA83567.1 - 0.18 12.0 5.6 0.63 10.3 0.6 2.7 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 S_100 PF01023.19 EFA83567.1 - 0.36 10.6 9.3 0.9 9.3 0.3 3.7 3 2 0 3 3 3 0 S-100/ICaBP type calcium binding domain Kelch_6 PF13964.6 EFA83568.1 - 1.8e-16 59.7 1.6 1.1e-07 31.8 0.0 4.9 4 0 0 4 4 4 3 Kelch motif zf-B_box PF00643.24 EFA83568.1 - 1.6e-05 24.9 8.4 3.4e-05 23.9 8.4 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA83568.1 - 0.00013 21.9 0.3 0.028 14.4 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain DUF4637 PF15470.6 EFA83568.1 - 5.2 6.8 9.5 0.24 11.1 3.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Kelch_1 PF01344.25 EFA83568.1 - 8 6.1 12.0 0.94 9.1 0.9 4.2 5 1 0 5 5 5 0 Kelch motif Actin PF00022.19 EFA83569.1 - 4.8e-152 506.3 0.0 1.5e-151 504.6 0.0 1.6 1 1 0 1 1 1 1 Actin DHFR_1 PF00186.19 EFA83570.1 - 2e-45 154.4 0.2 4.4e-45 153.3 0.2 1.5 1 1 0 1 1 1 1 Dihydrofolate reductase Ank_2 PF12796.7 EFA83572.1 - 0.00063 20.3 0.0 0.01 16.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA83572.1 - 0.0075 16.7 0.1 18 6.3 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFA83572.1 - 0.01 16.4 0.2 17 6.1 0.0 4.2 4 1 1 5 5 5 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83572.1 - 0.029 14.7 0.0 8.6 6.8 0.0 4.1 4 1 1 5 5 5 0 Ankyrin repeats (many copies) DUF4116 PF13475.6 EFA83572.1 - 0.051 13.3 3.3 2.3 8.0 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4116) Arf PF00025.21 EFA83573.1 - 1.1e-49 168.3 0.0 1.4e-49 167.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFA83573.1 - 1.6e-11 44.0 0.1 2.6e-07 30.2 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFA83573.1 - 2.7e-08 34.1 0.0 4.8e-07 30.0 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA83573.1 - 4.2e-08 32.8 0.0 5.9e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA83573.1 - 1.8e-06 27.6 0.0 1.2e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFA83573.1 - 0.0011 19.1 0.0 0.011 15.8 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFA83573.1 - 0.097 12.0 0.0 1.3 8.3 0.0 2.0 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Actin PF00022.19 EFA83574.1 - 9.8e-114 380.1 0.0 7.6e-113 377.2 0.0 1.9 1 1 0 1 1 1 1 Actin SPRY PF00622.28 EFA83575.1 - 8.9e-09 35.5 0.3 8.9e-09 35.5 0.3 3.2 3 1 0 3 3 3 1 SPRY domain zf-Di19 PF05605.12 EFA83575.1 - 5.5e-08 33.0 13.2 3.6e-07 30.4 5.9 3.9 4 0 0 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_2 PF13639.6 EFA83575.1 - 8.5e-08 32.4 3.9 8.5e-08 32.4 3.9 3.6 2 1 2 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA83575.1 - 4.7e-06 26.3 3.7 4.7e-06 26.3 3.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA83575.1 - 9.4e-06 25.3 4.8 2.5e-05 23.9 4.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger FOXP-CC PF16159.5 EFA83575.1 - 0.0051 17.4 2.4 0.03 15.0 1.7 2.7 2 1 0 2 2 2 1 FOXP coiled-coil domain zf-RING_UBOX PF13445.6 EFA83575.1 - 0.0079 16.2 4.7 0.0079 16.2 4.7 3.1 4 0 0 4 4 3 1 RING-type zinc-finger zf-C2H2_9 PF16293.5 EFA83575.1 - 0.021 14.7 2.9 1.3 8.9 0.1 3.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) IBR PF01485.21 EFA83575.1 - 0.033 14.4 2.9 0.045 14.0 0.6 2.5 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain DZR PF12773.7 EFA83575.1 - 0.04 14.0 0.4 0.95 9.5 0.3 2.6 1 1 2 3 3 3 0 Double zinc ribbon zf-RING_5 PF14634.6 EFA83575.1 - 1.1 9.3 12.7 0.31 11.0 3.4 3.4 3 0 0 3 3 3 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA83575.1 - 2.6 8.0 16.1 0.22 11.4 4.0 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA83575.1 - 5.4 7.4 18.1 0.066 13.5 2.9 3.6 3 0 0 3 3 3 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA83575.1 - 8.9 6.3 15.7 1.6 8.7 2.3 3.6 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Metallophos PF00149.28 EFA83576.1 - 1.4e-38 133.4 0.1 1.9e-38 133.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EFA83576.1 - 0.14 11.7 0.0 0.21 11.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain CLU PF13236.6 EFA83577.1 - 2.3e-60 204.2 0.0 5.2e-60 203.0 0.0 1.7 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA83577.1 - 1.8e-07 31.4 0.0 1.8e-07 31.4 0.0 3.6 5 0 0 5 5 5 1 Translation initiation factor eIF3 subunit 135 TPR_17 PF13431.6 EFA83577.1 - 0.00015 21.9 3.8 0.42 11.1 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA83577.1 - 0.00061 19.7 1.9 0.14 12.4 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA83577.1 - 0.0012 18.6 2.1 0.14 12.0 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA83577.1 - 0.0079 16.3 0.1 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA83577.1 - 0.0099 16.6 0.1 0.15 12.9 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83577.1 - 0.029 14.0 0.0 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 TPR repeat SF1-HH PF16275.5 EFA83577.1 - 0.13 12.6 6.5 0.14 12.5 3.0 2.9 3 0 0 3 3 3 0 Splicing factor 1 helix-hairpin domain Coiled PF05710.12 EFA83578.1 - 6.5e-13 49.3 25.7 7.1e-13 49.2 25.7 1.0 1 0 0 1 1 1 1 Coiled coil Coiled PF05710.12 EFA83579.1 - 1.2e-12 48.5 18.1 1.4e-12 48.3 18.1 1.1 1 0 0 1 1 1 1 Coiled coil ABC_membrane PF00664.23 EFA83580.1 - 8e-127 422.6 24.5 7.5e-64 216.0 10.3 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA83580.1 - 5.2e-69 231.1 2.6 1.5e-33 116.2 0.0 3.1 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EFA83580.1 - 1e-16 61.0 0.0 7.3e-08 32.1 0.0 2.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EFA83580.1 - 2.3e-08 33.3 0.7 0.0012 17.7 0.1 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EFA83580.1 - 2.1e-06 27.8 0.0 0.049 13.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFA83580.1 - 8e-05 22.9 0.1 0.34 11.2 0.0 3.2 2 2 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 EFA83580.1 - 0.00038 20.6 4.2 1.5 9.1 0.1 4.3 3 2 0 3 3 2 2 Putative exonuclease SbcCD, C subunit SR-25 PF10500.9 EFA83580.1 - 0.00045 19.9 16.0 0.0009 18.9 16.0 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AAA_29 PF13555.6 EFA83580.1 - 0.00079 19.1 3.8 0.37 10.6 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA83580.1 - 0.0011 19.3 0.5 0.78 10.1 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EFA83580.1 - 0.0013 18.3 0.0 1 8.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF815 PF05673.13 EFA83580.1 - 0.013 14.6 0.0 2.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF1676 PF07898.13 EFA83580.1 - 0.017 15.2 0.7 0.056 13.5 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) IstB_IS21 PF01695.17 EFA83580.1 - 0.027 14.2 2.3 12 5.6 0.1 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein Roc PF08477.13 EFA83580.1 - 0.029 14.6 0.2 7.6 6.8 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EFA83580.1 - 0.034 14.1 0.2 29 4.6 0.0 3.8 4 1 0 4 4 4 0 AAA domain (dynein-related subfamily) YL1 PF05764.13 EFA83580.1 - 0.043 13.9 11.5 0.072 13.2 11.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Smg8_Smg9 PF10220.9 EFA83580.1 - 0.048 12.0 1.6 0.074 11.4 1.6 1.1 1 0 0 1 1 1 0 Smg8_Smg9 AAA_25 PF13481.6 EFA83580.1 - 0.071 12.7 0.1 8.4 5.9 0.0 2.9 3 0 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.23 EFA83580.1 - 0.088 12.9 0.2 44 4.2 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EFA83580.1 - 0.11 13.0 0.0 32 5.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain Cyclin PF08613.11 EFA83580.1 - 0.13 12.6 2.9 1.6 9.1 0.1 3.1 4 0 0 4 4 2 0 Cyclin LYRIC PF15686.5 EFA83580.1 - 0.18 11.4 7.8 0.32 10.5 7.8 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF4758 PF15950.5 EFA83580.1 - 0.51 10.7 6.5 2 8.8 0.1 3.6 4 0 0 4 4 4 0 Putative sperm flagellar membrane protein IMUP PF15761.5 EFA83580.1 - 0.59 10.9 14.8 1.2 9.8 14.8 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein PI3K_1B_p101 PF10486.9 EFA83580.1 - 0.78 7.4 4.0 1.2 6.9 4.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit U1snRNP70_N PF12220.8 EFA83580.1 - 1.1 9.9 9.3 0.64 10.7 6.4 2.1 2 0 0 2 2 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF2207 PF09972.9 EFA83580.1 - 1.5 7.5 17.4 0.28 9.9 0.2 3.5 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) THOC2_N PF16134.5 EFA83580.1 - 1.6 7.3 5.9 2.7 6.5 5.9 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus GET2 PF08690.10 EFA83580.1 - 3.3 7.3 8.4 0.11 12.2 1.7 1.8 2 0 0 2 2 1 0 GET complex subunit GET2 DUF3487 PF11990.8 EFA83580.1 - 3.4 7.6 15.3 6.5 6.7 3.4 4.7 5 0 0 5 5 4 0 Protein of unknown function (DUF3487) CCDC106 PF15794.5 EFA83580.1 - 5.7 6.6 12.6 13 5.4 12.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Macoilin PF09726.9 EFA83580.1 - 8.2 4.9 11.3 0.025 13.2 1.3 1.7 2 0 0 2 2 2 0 Macoilin family Cupin_8 PF13621.6 EFA83581.1 - 3.3e-28 99.1 0.0 4.8e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EFA83581.1 - 0.0031 17.9 0.0 0.018 15.4 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_1 PF00190.22 EFA83581.1 - 0.021 14.4 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Cupin RF-1 PF00472.20 EFA83582.1 - 1.1e-15 57.5 0.3 3.3e-15 56.1 0.3 1.7 1 0 0 1 1 1 1 RF-1 domain Kelch_6 PF13964.6 EFA83582.1 - 6.8e-13 48.4 8.9 5.8e-05 23.2 0.0 5.8 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EFA83582.1 - 0.00023 20.7 2.2 1.1 8.8 0.0 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EFA83582.1 - 0.005 16.8 3.9 2.2 8.4 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFA83582.1 - 0.0075 16.3 4.7 0.67 10.0 0.0 5.0 6 0 0 6 6 6 1 Galactose oxidase, central domain Choline_kin_N PF04428.14 EFA83582.1 - 0.026 14.2 0.1 0.061 13.0 0.1 1.6 1 0 0 1 1 1 0 Choline kinase N terminus DUF5618 PF18498.1 EFA83582.1 - 0.12 12.6 2.6 1 9.6 0.1 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5618) Kelch_3 PF13415.6 EFA83582.1 - 0.14 12.5 0.0 36 4.8 0.0 3.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA83583.1 - 1.2e-13 50.8 0.2 1.4e-05 25.2 0.0 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFA83583.1 - 7.3e-08 32.3 0.0 0.00081 19.4 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA83583.1 - 1.9e-07 30.6 2.2 0.00035 20.1 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFA83583.1 - 3.6e-05 23.9 0.1 0.016 15.5 0.0 2.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA83583.1 - 0.0001 22.1 0.4 1.3 9.1 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EFA83583.1 - 0.0025 17.7 0.1 0.68 10.0 0.1 2.8 2 0 0 2 2 2 1 Kelch motif Evr1_Alr PF04777.13 EFA83584.1 - 5e-29 100.7 2.3 9.1e-29 99.9 2.3 1.4 1 0 0 1 1 1 1 Erv1 / Alr family TM2 PF05154.16 EFA83585.1 - 4.3e-20 71.8 12.1 5.7e-20 71.4 12.1 1.1 1 0 0 1 1 1 1 TM2 domain AAA_33 PF13671.6 EFA83586.1 - 4.5e-31 107.9 0.0 6.4e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFA83586.1 - 0.00026 21.2 0.0 0.00036 20.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 EFA83586.1 - 0.00032 20.6 0.5 0.00032 20.6 0.5 1.5 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_18 PF13238.6 EFA83586.1 - 0.0012 19.4 0.1 0.0076 16.8 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA83586.1 - 0.096 13.1 0.0 0.2 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 EFA83586.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EFA83586.1 - 0.23 11.9 1.4 0.49 10.9 1.4 1.7 1 1 0 1 1 1 0 ABC transporter Coiled PF05710.12 EFA83587.1 - 1.6e-11 44.8 20.4 1.8e-11 44.7 20.4 1.0 1 0 0 1 1 1 1 Coiled coil DUF1754 PF08555.10 EFA83588.1 - 3.1e-07 31.1 19.0 4.5e-07 30.6 5.2 2.9 1 1 2 3 3 3 2 Eukaryotic family of unknown function (DUF1754) Coiled PF05710.12 EFA83588.1 - 0.24 12.2 11.2 0.59 11.0 11.1 1.8 2 0 0 2 2 2 0 Coiled coil Cir_N PF10197.9 EFA83589.1 - 5.3e-13 48.9 4.8 5.3e-13 48.9 4.8 3.5 3 1 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR RNA_polI_A34 PF08208.11 EFA83589.1 - 0.0038 17.3 3.6 0.0038 17.3 3.6 3.7 1 1 1 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 zf-CCHC_6 PF15288.6 EFA83589.1 - 0.01 15.7 0.1 0.025 14.4 0.1 1.6 1 0 0 1 1 1 0 Zinc knuckle HSP20 PF00011.21 EFA83591.1 - 0.003 17.7 0.1 0.011 15.9 0.1 2.0 1 1 0 1 1 1 1 Hsp20/alpha crystallin family MMR_HSR1 PF01926.23 EFA83591.1 - 0.079 13.0 0.1 0.21 11.7 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase DIOX_N PF14226.6 EFA83591.1 - 0.085 13.6 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal Thiol_cytolys_C PF17440.2 EFA83592.1 - 0.01 16.0 0.1 0.043 14.0 0.1 2.0 2 0 0 2 2 2 0 Thiol-activated cytolysin beta sandwich domain HEAT PF02985.22 EFA83593.1 - 4e-16 57.7 5.5 0.02 15.1 0.3 7.2 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.6 EFA83593.1 - 3.6e-13 49.7 0.0 0.1 13.1 0.0 6.8 6 1 0 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 EFA83593.1 - 2e-10 40.9 0.0 0.012 16.0 0.0 5.7 4 2 2 7 7 7 3 HEAT repeats Arm PF00514.23 EFA83593.1 - 0.00098 19.1 4.6 2.4 8.3 0.0 5.0 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat DUF445 PF04286.12 EFA83593.1 - 1.2 8.9 10.6 0.088 12.6 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF445) RP-C_C PF11800.8 EFA83593.1 - 4.5 7.3 19.9 1.5 8.9 1.7 2.9 3 0 0 3 3 3 0 Replication protein C C-terminal region SUIM_assoc PF16619.5 EFA83593.1 - 5.3 7.2 16.0 4.8 7.3 7.7 3.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 S-methyl_trans PF02574.16 EFA83594.1 - 0.018 14.9 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Homocysteine S-methyltransferase Actin PF00022.19 EFA83595.1 - 4.8e-152 506.3 0.0 1.5e-151 504.6 0.0 1.6 1 1 0 1 1 1 1 Actin VASt PF16016.5 EFA83596.1 - 7.8e-28 97.8 0.7 7.8e-28 97.8 0.7 3.3 3 1 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EFA83596.1 - 3.5e-12 46.2 0.4 8.9e-12 44.9 0.4 1.7 1 0 0 1 1 1 1 GRAM domain Ras PF00071.22 EFA83597.1 - 1e-55 187.7 0.2 1.3e-55 187.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA83597.1 - 1.3e-30 106.0 0.1 2.1e-30 105.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83597.1 - 5.3e-11 42.3 0.0 6.9e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA83597.1 - 0.00055 19.4 0.0 0.00063 19.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA83597.1 - 0.004 17.1 0.0 1.2 9.1 0.0 2.4 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA83597.1 - 0.011 15.8 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA83597.1 - 0.027 14.0 0.0 0.058 12.9 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Ribosomal_L37 PF08561.10 EFA83598.1 - 0.54 10.8 10.2 0.85 10.2 6.1 2.4 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L37 Proteasome PF00227.26 EFA83599.1 - 3.9e-53 179.8 0.1 1.2e-52 178.1 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EFA83599.1 - 1.7e-13 50.0 0.0 2.7e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5018 PF16410.5 EFA83599.1 - 0.032 12.9 0.0 0.047 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) DUF4916 PF16262.5 EFA83599.1 - 0.14 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4916) DMPK_coil PF08826.10 EFA83599.1 - 0.24 11.6 2.2 5 7.3 0.1 2.6 2 0 0 2 2 2 0 DMPK coiled coil domain like Rho_GDI PF02115.17 EFA83600.1 - 3e-57 193.5 0.5 3.3e-57 193.4 0.5 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Kelch_6 PF13964.6 EFA83601.1 - 3.6e-16 58.8 3.5 0.00018 21.6 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 EFA83601.1 - 3.4e-07 30.1 1.6 0.0029 17.6 0.0 4.9 4 2 1 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA83601.1 - 2.6e-05 23.7 2.4 0.51 10.0 0.1 4.2 4 0 0 4 4 4 2 Kelch motif zf-B_box PF00643.24 EFA83601.1 - 0.0061 16.7 13.4 0.014 15.6 13.4 1.6 1 0 0 1 1 1 1 B-box zinc finger HPS3_N PF14761.6 EFA83601.1 - 0.021 14.4 0.0 0.067 12.7 0.0 1.8 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 PspA_IM30 PF04012.12 EFA83601.1 - 0.024 14.2 0.5 0.041 13.5 0.5 1.3 1 0 0 1 1 1 0 PspA/IM30 family Kelch_2 PF07646.15 EFA83601.1 - 0.027 14.4 0.3 24 5.1 0.1 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 EFA83601.1 - 0.033 14.5 0.7 1.8 8.9 0.0 3.4 4 0 0 4 4 3 0 Galactose oxidase, central domain Cucumo_coat PF00760.18 EFA83601.1 - 0.066 12.9 0.0 2.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Cucumovirus coat protein Serine_rich PF08824.10 EFA83601.1 - 0.1 12.6 1.3 0.25 11.3 1.3 1.6 1 0 0 1 1 1 0 Serine rich protein interaction domain Reg_prop PF07494.11 EFA83601.1 - 0.22 11.8 1.0 1e+02 3.7 0.0 3.9 3 0 0 3 3 3 0 Two component regulator propeller IMUP PF15761.5 EFA83601.1 - 0.68 10.6 4.9 1.4 9.6 4.9 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Med9 PF07544.13 EFA83601.1 - 1.5 9.0 8.0 0.2 11.7 0.3 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Ssu72 PF04722.13 EFA83602.1 - 2.3e-73 245.8 0.0 2.9e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 Ssu72-like protein Sad1_UNC PF07738.13 EFA83603.1 - 2.4e-34 118.2 0.8 7.2e-34 116.6 0.0 2.2 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal CD99L2 PF12301.8 EFA83603.1 - 0.044 14.1 2.7 0.078 13.3 2.7 1.3 1 0 0 1 1 1 0 CD99 antigen like protein 2 Cytochrom_B562 PF07361.11 EFA83603.1 - 0.17 12.5 3.7 0.42 11.3 2.5 2.3 1 1 0 1 1 1 0 Cytochrome b562 NYD-SP28 PF14772.6 EFA83603.1 - 0.93 9.6 15.8 0.25 11.4 2.6 3.2 2 1 1 3 3 3 0 Sperm tail DDE_Tnp_1_3 PF13612.6 EFA83603.1 - 7.4 6.6 8.3 5 7.1 0.9 2.6 2 1 1 3 3 3 0 Transposase DDE domain Dickkopf_N PF04706.12 EFA83604.1 - 0.0094 16.4 13.7 0.0094 16.4 13.7 7.1 4 3 2 6 6 6 3 Dickkopf N-terminal cysteine-rich region Pro_dh PF01619.18 EFA83605.1 - 3.7e-74 249.9 0.0 3.7e-74 249.9 0.0 1.4 2 0 0 2 2 2 1 Proline dehydrogenase PEP_mutase PF13714.6 EFA83605.1 - 0.2 11.1 0.0 0.36 10.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase KTI12 PF08433.10 EFA83606.1 - 7.8e-83 278.1 1.4 7.8e-83 278.1 1.4 3.0 2 1 1 3 3 3 1 Chromatin associated protein KTI12 RRM_1 PF00076.22 EFA83606.1 - 7.9e-06 25.6 0.1 0.046 13.5 0.0 3.7 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_33 PF13671.6 EFA83606.1 - 7.6e-05 22.9 0.0 0.00031 20.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain BUD22 PF09073.10 EFA83606.1 - 0.29 10.4 15.3 0.41 9.9 15.3 1.2 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 EFA83606.1 - 4 6.1 14.1 6.1 5.5 14.1 1.2 1 0 0 1 1 1 0 Presenilin TrbI PF03743.14 EFA83606.1 - 4.3 7.1 8.2 4.2 7.2 6.3 1.9 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein CBM49 PF09478.10 EFA83608.1 - 9.8e-20 70.7 2.2 1.4e-19 70.1 2.2 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 DUF4352 PF11611.8 EFA83608.1 - 0.083 13.2 1.7 0.13 12.6 1.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4352) CBM_2 PF00553.19 EFA83608.1 - 0.2 12.0 3.8 0.4 11.0 3.8 1.6 1 1 0 1 1 1 0 Cellulose binding domain Ig_5 PF16681.5 EFA83609.1 - 0.054 13.9 7.3 0.077 13.4 1.8 3.1 2 1 1 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 EFA83609.1 - 0.25 11.6 7.1 0.12 12.6 1.9 3.1 4 0 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain SSP160 PF06933.11 EFA83609.1 - 2.8 6.0 18.6 4.1 5.5 18.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 EFA83609.1 - 4.3 7.3 29.3 8.3 6.4 29.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Ank_2 PF12796.7 EFA83611.1 - 0.015 15.9 3.5 0.3 11.7 0.3 4.1 3 1 0 3 3 3 0 Ankyrin repeats (3 copies) AMMECR1 PF01871.17 EFA83612.1 - 7.7e-47 159.0 0.0 9.5e-47 158.7 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 COX_ARM PF06481.14 EFA83612.1 - 0.12 12.3 0.6 0.42 10.6 0.0 1.9 2 0 0 2 2 2 0 COX Aromatic Rich Motif AIM24 PF01987.17 EFA83613.1 - 5.7e-56 189.5 0.7 8e-56 189.0 0.7 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Amidase PF01425.21 EFA83614.1 - 8.3e-93 311.8 0.0 1.2e-92 311.2 0.0 1.2 1 0 0 1 1 1 1 Amidase Ank_2 PF12796.7 EFA83615.1 - 3.9e-51 171.6 12.2 4e-13 49.8 1.2 5.5 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83615.1 - 1.4e-46 156.3 3.7 4.9e-11 42.9 0.0 6.8 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFA83615.1 - 3.9e-42 140.9 11.7 2.7e-07 30.7 0.1 9.0 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 EFA83615.1 - 7.4e-41 137.7 10.9 1.3e-09 38.1 0.0 9.3 2 1 7 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83615.1 - 3.3e-40 131.5 4.7 0.00033 20.9 0.0 9.6 9 0 0 9 9 9 7 Ankyrin repeat F-box-like PF12937.7 EFA83615.1 - 2.4e-09 36.9 0.0 5.3e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA83615.1 - 2.5e-08 33.6 0.5 5.2e-08 32.6 0.1 1.8 2 0 0 2 2 2 1 F-box domain DUF237 PF03072.14 EFA83615.1 - 7.2 6.7 8.7 2.1 8.4 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF237) RasGEF PF00617.19 EFA83616.1 - 6e-56 189.4 0.0 2.2e-55 187.6 0.0 2.1 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA83616.1 - 1.7e-30 105.4 2.0 1.7e-30 105.4 2.0 6.6 5 3 0 6 6 6 1 RasGEF N-terminal motif YhhN PF07947.14 EFA83617.1 - 1.2e-36 126.0 24.3 1.2e-36 126.0 24.3 1.5 1 1 0 1 1 1 1 YhhN family Lig_chan PF00060.26 EFA83617.1 - 8.4 6.2 11.6 5.3 6.9 8.8 2.3 2 1 0 2 2 2 0 Ligand-gated ion channel Strep_SA_rep PF06696.11 EFA83618.1 - 0.17 11.9 0.9 13 5.9 0.1 2.7 2 0 0 2 2 2 0 Streptococcal surface antigen repeat CLZ PF16526.5 EFA83619.1 - 0.13 12.7 0.1 0.24 11.8 0.1 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4140 PF13600.6 EFA83619.1 - 0.5 10.8 3.0 7.8 7.0 3.0 2.4 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) NOP19 PF10863.8 EFA83619.1 - 1.8 8.4 6.7 0.37 10.6 2.2 2.0 2 1 0 2 2 2 0 Nucleolar protein 19 Mito_fiss_reg PF05308.11 EFA83619.1 - 5.1 7.1 23.4 0.19 11.8 13.9 2.5 1 1 1 2 2 2 0 Mitochondrial fission regulator Kelch_5 PF13854.6 EFA83620.1 - 1.8e-44 149.1 5.3 1.2e-10 41.2 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFA83620.1 - 2.8e-42 142.5 13.4 2.4e-10 40.3 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA83620.1 - 7.7e-41 137.1 11.9 1.5e-08 34.6 0.4 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EFA83620.1 - 3.5e-38 128.2 19.5 1.6e-11 43.6 0.2 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EFA83620.1 - 4.9e-35 118.9 6.6 4.6e-09 35.7 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFA83620.1 - 7.5e-35 118.6 11.9 6.4e-07 29.5 0.3 7.3 7 0 0 7 7 7 5 Galactose oxidase, central domain SAM_2 PF07647.17 EFA83620.1 - 1.3e-12 47.7 0.8 2.6e-12 46.7 0.8 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFA83620.1 - 3e-12 46.8 0.5 5.3e-12 46.0 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Prefoldin PF02996.17 EFA83620.1 - 0.048 13.6 1.5 0.089 12.7 1.5 1.4 1 0 0 1 1 1 0 Prefoldin subunit Asp PF00026.23 EFA83620.1 - 0.078 12.4 0.1 11 5.4 0.0 3.1 3 1 0 3 3 3 0 Eukaryotic aspartyl protease TSC22 PF01166.18 EFA83620.1 - 0.093 13.1 0.9 4 7.8 0.2 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF3972 PF13118.6 EFA83620.1 - 0.31 11.5 4.7 0.45 11.0 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) LPP20 PF02169.16 EFA83620.1 - 3.5 8.0 7.8 0.23 11.8 1.0 2.2 2 0 0 2 2 2 0 LPP20 lipoprotein COMM_domain PF07258.14 EFA83620.1 - 4.9 7.3 10.1 19 5.5 0.0 3.5 3 0 0 3 3 3 0 COMM domain Rep_fac-A_C PF08646.10 EFA83621.1 - 1.3e-05 25.0 1.8 2.8e-05 23.9 1.1 2.0 2 0 0 2 2 2 1 Replication factor-A C terminal domain POT1PC PF16686.5 EFA83621.1 - 6.2e-05 22.9 1.8 0.01 15.7 0.2 3.2 2 1 1 3 3 3 1 ssDNA-binding domain of telomere protection protein tRNA_anti-codon PF01336.25 EFA83621.1 - 8.6e-05 22.5 0.8 3.9 7.5 0.0 3.5 3 0 0 3 3 3 3 OB-fold nucleic acid binding domain DUF3269 PF11673.8 EFA83621.1 - 0.0019 18.5 0.2 0.0068 16.7 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3269) ThiF PF00899.21 EFA83622.1 - 1.7e-67 227.4 0.0 3.3e-67 226.4 0.0 1.5 1 1 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EFA83622.1 - 6.8e-21 74.7 3.0 2.5e-20 72.9 1.8 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EFA83622.1 - 3.3e-06 27.2 9.0 0.00037 20.5 0.2 3.5 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 EFA83622.1 - 0.00028 21.0 0.0 0.00064 19.8 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EFA83622.1 - 0.0007 20.0 0.0 0.0021 18.5 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Ldh_1_N PF00056.23 EFA83622.1 - 0.018 15.1 1.2 0.18 11.9 0.1 2.5 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFA83622.1 - 0.023 13.8 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Pyr_redox PF00070.27 EFA83622.1 - 0.16 12.6 0.0 0.36 11.4 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SHMT PF00464.19 EFA83623.1 - 3.2e-184 612.2 0.0 3.7e-184 611.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 EFA83623.1 - 0.002 17.4 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Macro PF01661.21 EFA83623.1 - 0.037 14.1 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 Macro domain ABC2_membrane_3 PF12698.7 EFA83624.1 - 1.2e-33 116.7 25.3 1.7e-33 116.2 25.3 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 EFA83624.1 - 6.1e-24 85.1 0.0 1.9e-23 83.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EFA83624.1 - 1.8e-10 41.2 0.1 2.5e-07 30.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane PF01061.24 EFA83624.1 - 4.5e-06 26.2 16.6 4.5e-06 26.2 16.6 2.7 3 0 0 3 3 3 2 ABC-2 type transporter AAA_23 PF13476.6 EFA83624.1 - 7.9e-05 23.2 1.9 0.0042 17.6 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EFA83624.1 - 0.098 12.4 0.2 0.21 11.3 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 EFA83624.1 - 0.3 10.8 4.9 3 7.5 0.1 3.0 3 1 0 4 4 4 0 AAA ATPase domain Peptidase_M16_C PF05193.21 EFA83625.1 - 1.3e-26 93.7 0.0 3.2e-26 92.5 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFA83625.1 - 7.4e-24 84.4 0.3 1.6e-23 83.4 0.1 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) EGF_2 PF07974.13 EFA83627.1 - 3.4e-05 24.1 9.2 6.5e-05 23.2 9.2 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFA83627.1 - 4.3e-05 23.4 6.2 0.0001 22.3 6.2 1.6 1 0 0 1 1 1 1 Tenascin EGF domain EGF_alliinase PF04863.13 EFA83627.1 - 2.1 8.8 5.7 4.6 7.7 5.7 1.6 1 0 0 1 1 1 0 Alliinase EGF-like domain hEGF PF12661.7 EFA83627.1 - 6.2 7.6 9.1 18 6.1 9.1 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF FA_desaturase PF00487.24 EFA83628.1 - 0.0043 16.9 0.9 0.006 16.5 0.9 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Mito_carr PF00153.27 EFA83629.1 - 2.4e-66 219.7 5.2 4.7e-24 84.1 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PH PF00169.29 EFA83630.1 - 1.6e-05 25.4 1.1 6.4e-05 23.4 0.2 2.6 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 EFA83630.1 - 0.001 19.1 0.1 0.041 14.0 0.1 2.6 2 0 0 2 2 2 1 PH domain RGS PF00615.19 EFA83630.1 - 0.053 13.8 0.3 0.053 13.8 0.3 3.0 3 0 0 3 3 3 0 Regulator of G protein signaling domain DUF3439 PF11921.8 EFA83630.1 - 8.9 6.3 7.8 2.1 8.3 2.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) IF4E PF01652.18 EFA83631.1 - 3.3e-52 176.5 1.0 6.3e-52 175.6 0.6 1.6 2 0 0 2 2 2 1 Eukaryotic initiation factor 4E Tim54 PF11711.8 EFA83631.1 - 0.12 11.2 4.0 0.17 10.7 4.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Menin PF05053.13 EFA83631.1 - 2.7 6.3 8.2 3.7 5.8 8.2 1.1 1 0 0 1 1 1 0 Menin Malic_M PF03949.15 EFA83632.1 - 1.2e-103 345.9 0.1 1.6e-103 345.4 0.1 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFA83632.1 - 1.3e-68 230.4 0.0 4.2e-68 228.7 0.0 1.8 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain HHH_2 PF12826.7 EFA83632.1 - 0.14 12.3 0.2 1.9 8.6 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif Rcd1 PF04078.13 EFA83634.1 - 3.4e-92 308.4 11.9 4.7e-92 307.9 11.9 1.2 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DUF3446 PF11928.8 EFA83634.1 - 0.00083 19.6 1.3 0.0026 18.0 1.3 1.9 1 0 0 1 1 1 1 Early growth response N-terminal domain Ada3 PF10198.9 EFA83635.1 - 5.7e-12 45.9 12.7 5.7e-12 45.9 12.7 2.8 3 0 0 3 3 3 1 Histone acetyltransferases subunit 3 AT_hook PF02178.19 EFA83635.1 - 0.14 12.1 12.4 2.6 8.2 4.0 2.9 2 0 0 2 2 2 0 AT hook motif Dymeclin PF09742.9 EFA83636.1 - 5.3e-76 256.4 38.3 1.2e-75 255.2 37.6 1.7 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 EFA83636.1 - 0.0018 16.6 11.9 0.0018 16.6 11.9 3.4 3 1 1 4 4 4 3 High-temperature-induced dauer-formation protein Arf PF00025.21 EFA83637.1 - 8.2e-58 194.7 1.2 8.9e-58 194.6 1.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA83637.1 - 2.1e-13 50.5 0.1 2.9e-13 50.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFA83637.1 - 8e-13 48.3 3.7 3.5e-07 29.7 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFA83637.1 - 4.2e-10 39.5 0.1 5.1e-10 39.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFA83637.1 - 6e-10 38.9 0.0 7.1e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFA83637.1 - 1.2e-07 31.4 0.0 1.5e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFA83637.1 - 6.7e-07 29.4 0.0 9.1e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 EFA83637.1 - 0.0051 16.9 0.4 0.0063 16.5 0.4 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EFA83637.1 - 0.025 14.0 0.1 0.032 13.7 0.1 1.2 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 EFA83637.1 - 0.035 13.6 0.3 0.16 11.5 0.3 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF3522 PF12036.8 EFA83638.1 - 1.8e-46 158.8 8.7 1.8e-46 158.8 8.7 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3522) DUF4834 PF16118.5 EFA83638.1 - 0.042 14.8 0.8 0.042 14.8 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Secretin_N_2 PF07655.13 EFA83638.1 - 0.18 12.4 34.9 2 9.0 21.3 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Gti1_Pac2 PF09729.9 EFA83638.1 - 0.75 9.9 7.0 3.1 7.9 5.2 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family IU_nuc_hydro PF01156.19 EFA83639.1 - 6.1e-86 288.7 0.3 7.1e-86 288.5 0.3 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CBFD_NFYB_HMF PF00808.23 EFA83640.1 - 1.4e-15 57.3 0.1 2.8e-15 56.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFA83640.1 - 6.2e-06 26.6 3.3 7.6e-06 26.3 3.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 SDA1 PF05285.12 EFA83640.1 - 0.0054 16.2 16.5 0.0051 16.3 16.5 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 EFA83640.1 - 0.0086 14.4 14.8 0.0076 14.5 14.8 1.0 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 EFA83640.1 - 0.054 11.8 12.0 0.052 11.8 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EFA83640.1 - 0.13 12.4 17.1 0.15 12.2 17.1 1.1 1 0 0 1 1 1 0 YL1 nuclear protein RNA_pol_Rpc4 PF05132.14 EFA83640.1 - 0.55 10.6 5.6 0.66 10.4 5.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 BUD22 PF09073.10 EFA83640.1 - 0.65 9.3 16.1 0.75 9.1 16.1 1.2 1 0 0 1 1 1 0 BUD22 RPN2_C PF18004.1 EFA83640.1 - 1.1 9.1 13.0 1.7 8.6 13.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 EFA83640.1 - 1.2 7.1 24.0 1.4 7.0 24.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 EFA83640.1 - 1.5 7.9 13.9 1.9 7.6 13.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RRN3 PF05327.11 EFA83640.1 - 2.1 6.8 14.2 2.3 6.7 14.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 IFT57 PF10498.9 EFA83640.1 - 4 6.3 15.1 5.9 5.8 15.1 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Sporozoite_P67 PF05642.11 EFA83640.1 - 4.1 5.4 13.1 5.1 5.0 13.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3292 PF11696.8 EFA83640.1 - 6.2 5.1 8.8 7 4.9 8.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3245 PF11595.8 EFA83640.1 - 6.5 7.2 17.4 10 6.5 17.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Citrate_bind PF16114.5 EFA83641.1 - 9.4e-81 269.5 0.0 1.3e-80 269.1 0.0 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EFA83641.1 - 7.9e-15 55.0 0.0 1.4e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Gifsy-2 PF13856.6 EFA83641.1 - 0.086 13.2 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage LOH1CR12 PF10158.9 EFA83642.1 - 8.2e-05 22.6 0.4 8.2e-05 22.6 0.4 2.2 1 1 0 2 2 2 1 Tumour suppressor protein Folliculin PF11704.8 EFA83642.1 - 1.8 8.4 15.1 2 8.3 7.0 2.3 2 1 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF5345 PF17280.2 EFA83642.1 - 3.3 7.8 5.3 13 5.8 4.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5345) ANAPC_CDC26 PF10471.9 EFA83642.1 - 4.4 8.2 23.1 5.6 7.9 20.7 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 SID-1_RNA_chan PF13965.6 EFA83642.1 - 5.2 5.4 7.9 8.7 4.6 7.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DEAD PF00270.29 EFA83643.1 - 2.8e-40 138.0 1.5 9.9e-40 136.2 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA83643.1 - 1.7e-26 92.7 8.0 8.7e-26 90.5 1.0 3.4 4 1 0 4 4 4 2 Helicase conserved C-terminal domain PPP4R2 PF09184.11 EFA83643.1 - 0.0051 16.5 3.6 0.0051 16.5 3.6 3.3 2 1 0 2 2 2 1 PPP4R2 ANAPC15 PF15243.6 EFA83644.1 - 0.0034 17.7 6.0 0.007 16.7 6.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 15 Glyco_transf_22 PF03901.17 EFA83645.1 - 1.9e-71 241.5 33.0 2.7e-71 241.0 33.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF4419 PF14388.6 EFA83645.1 - 0.046 13.1 0.0 0.82 9.0 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4419) DAGAT PF03982.13 EFA83646.1 - 8.9e-108 359.7 0.0 1.1e-107 359.4 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Mannosyl_trans PF05007.13 EFA83647.1 - 2.7e-36 125.8 9.4 4.8e-36 124.9 9.4 1.4 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EFA83647.1 - 8e-12 44.9 15.4 1.1e-11 44.5 15.4 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EFA83647.1 - 3.7e-06 26.8 0.8 3.7e-06 26.8 0.8 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 87 AhpC-TSA_2 PF13911.6 EFA83647.1 - 0.067 13.3 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 AhpC/TSA antioxidant enzyme Sigma_reg_N PF13800.6 EFA83647.1 - 3.2 8.1 9.6 14 6.0 0.2 3.4 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF373 PF04123.13 EFA83648.1 - 4.5 6.6 12.6 2.9 7.2 3.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Membrane_bind PF14564.6 EFA83649.1 - 1.2e-34 119.1 0.1 2.7e-34 117.9 0.1 1.7 1 0 0 1 1 1 1 Membrane binding IMD PF08397.11 EFA83649.1 - 3.1e-17 62.7 7.2 4.2e-17 62.3 7.2 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_1 PF00018.28 EFA83649.1 - 7e-15 54.4 0.1 2.3e-14 52.7 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EFA83649.1 - 1.1e-12 47.6 0.0 2.5e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA83649.1 - 7.5e-10 38.4 0.0 2.6e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain BAR_3 PF16746.5 EFA83649.1 - 0.0029 17.4 9.9 0.0072 16.1 9.8 1.5 1 1 0 1 1 1 1 BAR domain of APPL family BAR PF03114.18 EFA83649.1 - 0.036 13.7 10.2 0.079 12.6 10.2 1.5 1 1 0 1 1 1 0 BAR domain SopE_GEF PF07487.13 EFA83649.1 - 0.065 13.3 1.3 0.15 12.1 1.3 1.6 1 0 0 1 1 1 0 SopE GEF domain Cytochrom_B562 PF07361.11 EFA83649.1 - 0.082 13.6 4.5 0.42 11.3 2.4 2.4 2 0 0 2 2 2 0 Cytochrome b562 Gp-FAR-1 PF05823.12 EFA83649.1 - 0.11 12.8 0.1 0.11 12.8 0.1 2.4 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Ferritin PF00210.24 EFA83649.1 - 0.26 11.2 4.4 12 5.8 4.4 2.4 1 1 1 2 2 2 0 Ferritin-like domain SNF2_N PF00176.23 EFA83651.1 - 3.6e-53 180.5 0.0 7e-53 179.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA83651.1 - 3.1e-15 56.5 0.0 1.2e-14 54.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA83651.1 - 2.5e-10 40.6 0.0 1.2e-09 38.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit FliW PF02623.15 EFA83651.1 - 0.1 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 FliW protein YlzJ PF14035.6 EFA83651.1 - 0.13 12.5 0.2 0.48 10.7 0.2 2.0 1 0 0 1 1 1 0 YlzJ-like protein Response_reg PF00072.24 EFA83652.1 - 1.1e-33 115.8 3.7 3.2e-28 98.1 0.9 3.6 3 0 0 3 3 3 3 Response regulator receiver domain HATPase_c PF02518.26 EFA83652.1 - 3.4e-28 98.4 0.0 1.1e-27 96.8 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFA83652.1 - 1e-16 60.7 3.5 1.5e-16 60.2 0.9 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EFA83652.1 - 1.5e-09 38.0 0.0 1.1e-08 35.2 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EFA83652.1 - 3.6e-08 33.6 0.0 7.2e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EFA83652.1 - 4.6e-06 26.8 0.0 1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EFA83652.1 - 0.00012 22.0 0.0 0.00032 20.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold DUF333 PF03891.15 EFA83654.1 - 8.2e-08 32.3 0.0 2.3e-07 30.9 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF333) zf-CCHC PF00098.23 EFA83657.1 - 9.2e-24 82.4 28.2 1e-06 28.5 0.5 4.1 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 EFA83657.1 - 7.9e-06 25.5 20.2 0.097 12.4 1.2 4.1 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 EFA83657.1 - 0.0063 16.3 1.1 0.0063 16.3 1.1 4.5 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_3 PF13917.6 EFA83657.1 - 0.15 12.0 23.9 0.27 11.3 0.5 4.1 1 1 3 4 4 4 0 Zinc knuckle zf-CCHC_5 PF14787.6 EFA83657.1 - 2.4 7.9 25.8 1.2 9.0 1.9 4.0 2 2 2 4 4 4 0 GAG-polyprotein viral zinc-finger Rpr2 PF04032.16 EFA83658.1 - 4.8e-10 39.6 1.2 4.8e-10 39.6 1.2 5.0 3 2 1 4 4 4 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain ER PF01133.17 EFA83659.1 - 3.1e-37 126.5 1.2 8.6e-37 125.1 1.2 1.8 1 0 0 1 1 1 1 Enhancer of rudimentary BAR PF03114.18 EFA83659.1 - 5.2e-18 65.6 9.0 1.1e-17 64.5 9.0 1.4 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EFA83659.1 - 2.2e-12 46.4 0.0 4.1e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA83659.1 - 2.6e-11 43.2 0.0 5.4e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA83659.1 - 7.3e-09 35.2 0.0 1.6e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Synaptonemal_3 PF15191.6 EFA83659.1 - 0.012 15.3 1.7 0.02 14.7 0.9 1.7 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 Fib_alpha PF08702.10 EFA83659.1 - 3.4 7.9 8.2 1.1 9.5 3.8 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DEAD PF00270.29 EFA83660.1 - 6.1e-45 153.1 0.1 1.6e-44 151.7 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA83660.1 - 1.8e-32 112.0 9.1 1.2e-29 102.8 0.1 3.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain AAA_19 PF13245.6 EFA83660.1 - 0.0022 18.3 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Methyltransf_2 PF00891.18 EFA83660.1 - 0.029 13.7 0.0 0.064 12.5 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain AAA_22 PF13401.6 EFA83660.1 - 0.12 12.6 1.1 1.1 9.5 1.1 2.5 1 1 0 1 1 1 0 AAA domain EGF_CA PF07645.15 EFA83661.1 - 5.1e-17 61.8 46.6 1.4e-08 34.8 9.6 7.3 7 0 0 7 7 7 3 Calcium-binding EGF domain cEGF PF12662.7 EFA83661.1 - 6.9e-10 38.7 31.7 6e-05 22.9 2.2 5.4 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF PF00008.27 EFA83661.1 - 1.2e-06 28.6 72.2 0.0014 18.9 10.6 6.6 5 1 0 5 5 5 4 EGF-like domain TIG PF01833.24 EFA83661.1 - 1.6e-05 24.9 1.4 1.6e-05 24.9 1.4 4.9 6 0 0 6 6 6 2 IPT/TIG domain EGF_2 PF07974.13 EFA83661.1 - 0.0011 19.3 76.2 0.0039 17.5 14.0 6.1 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.7 EFA83661.1 - 0.0015 19.1 21.5 0.003 18.1 11.0 7.1 5 1 0 5 5 5 3 Human growth factor-like EGF MDM10 PF12519.8 EFA83662.1 - 0.00079 18.4 0.3 0.0014 17.6 0.2 1.4 1 1 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Beta-lactamase PF00144.24 EFA83663.1 - 7.8e-27 94.4 1.4 2.2e-26 92.9 1.4 1.6 1 1 0 1 1 1 1 Beta-lactamase RabGAP-TBC PF00566.18 EFA83664.1 - 2.9e-14 53.3 23.1 8.7e-12 45.1 18.0 3.5 2 1 0 2 2 2 2 Rab-GTPase-TBC domain Lin-8 PF03353.15 EFA83664.1 - 0.042 13.4 2.9 0.057 13.0 2.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 EFA83664.1 - 0.49 8.9 11.5 0.65 8.5 11.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF4061 PF13270.6 EFA83665.1 - 3.5e-17 62.5 3.6 3.5e-17 62.5 3.6 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4061) BBS1 PF14779.6 EFA83665.1 - 0.1 12.0 3.0 0.74 9.2 0.4 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 Pkinase PF00069.25 EFA83666.1 - 2.4e-51 174.6 0.0 6.4e-51 173.2 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83666.1 - 2.5e-19 69.6 0.0 6.4e-18 65.0 0.0 3.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA83666.1 - 0.0019 18.1 0.1 0.0037 17.2 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA83666.1 - 0.003 16.9 0.0 0.006 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Cullin PF00888.22 EFA83667.1 - 2e-195 651.0 11.1 2.4e-195 650.7 11.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFA83667.1 - 8.8e-05 22.5 1.1 8.8e-05 22.5 1.1 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain Phage_TAC_12 PF12363.8 EFA83667.1 - 0.021 15.2 0.4 0.16 12.4 0.1 2.6 2 1 0 2 2 2 0 Phage tail assembly chaperone protein, TAC Post_transc_reg PF13797.6 EFA83667.1 - 0.13 12.1 3.0 15 5.5 0.0 3.4 3 0 0 3 3 3 0 Post-transcriptional regulator RhoGEF PF00621.20 EFA83668.1 - 4.9e-52 176.8 14.2 2e-47 161.8 7.3 3.2 3 0 0 3 3 3 2 RhoGEF domain RhoGAP PF00620.27 EFA83668.1 - 6.3e-44 149.5 0.4 9.8e-42 142.4 0.1 2.7 2 0 0 2 2 2 1 RhoGAP domain SH3_9 PF14604.6 EFA83668.1 - 6.4e-13 48.3 0.1 1.2e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA83668.1 - 6.4e-11 41.7 0.1 1.4e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA83668.1 - 1.3e-08 34.4 0.0 3.2e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 EFA83668.1 - 1.3e-05 25.6 0.5 4.3e-05 24.0 0.5 1.9 1 0 0 1 1 1 1 PH domain Baculo_LEF-11 PF06385.12 EFA83668.1 - 0.58 10.7 6.5 0.22 12.1 1.0 3.1 3 0 0 3 3 3 0 Baculovirus LEF-11 protein IBR PF01485.21 EFA83669.1 - 1.5e-07 31.6 35.6 9.4e-07 29.0 7.6 3.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain CUE PF02845.16 EFA83669.1 - 5.4e-06 26.0 2.7 7.6e-06 25.5 0.1 2.6 3 0 0 3 3 3 1 CUE domain zf-RING_UBOX PF13445.6 EFA83669.1 - 0.0002 21.3 6.6 0.0002 21.3 6.6 3.7 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFA83669.1 - 0.00047 19.9 4.2 0.00047 19.9 4.2 3.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA83669.1 - 0.0015 18.8 9.0 0.0015 18.8 9.0 4.1 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 EFA83669.1 - 0.0022 17.8 8.1 0.0022 17.8 8.1 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) UBA PF00627.31 EFA83669.1 - 0.027 14.4 0.1 0.082 12.8 0.1 1.9 1 0 0 1 1 1 0 UBA/TS-N domain Membrane_bind PF14564.6 EFA83670.1 - 0.036 14.5 1.7 0.091 13.2 0.7 2.2 1 1 1 2 2 2 0 Membrane binding ABC_tran PF00005.27 EFA83671.1 - 2e-27 96.4 0.0 3.7e-27 95.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA83671.1 - 4.8e-24 85.1 41.2 9.9e-24 84.1 39.3 2.2 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA83671.1 - 1e-12 48.5 0.2 2.2e-07 31.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane PF01061.24 EFA83671.1 - 0.00015 21.3 22.4 0.00015 21.3 22.4 2.4 2 0 0 2 2 2 1 ABC-2 type transporter AAA_23 PF13476.6 EFA83671.1 - 0.00023 21.8 0.0 0.00046 20.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFA83671.1 - 0.0014 18.4 0.1 0.3 10.8 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein SMC_N PF02463.19 EFA83671.1 - 0.0036 16.8 0.3 1.4 8.3 0.0 2.7 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFA83671.1 - 0.0043 16.8 0.0 0.19 11.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 EFA83671.1 - 0.008 16.1 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_27 PF13514.6 EFA83671.1 - 0.042 13.4 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane_2 PF12679.7 EFA83671.1 - 0.051 12.8 12.5 0.11 11.8 12.5 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein AAA_30 PF13604.6 EFA83671.1 - 0.056 13.1 0.1 0.23 11.2 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFA83671.1 - 0.12 12.1 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TSNR_N PF04705.12 EFA83671.1 - 0.16 12.1 0.0 0.46 10.6 0.0 1.7 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus AAA_lid_1 PF17857.1 EFA83672.1 - 1.5 9.1 7.6 0.79 10.0 0.6 3.6 3 1 1 4 4 4 0 AAA+ lid domain Ank_2 PF12796.7 EFA83673.1 - 1.9e-14 54.0 12.2 4.5e-09 36.8 0.2 3.2 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83673.1 - 1.8e-10 41.2 3.2 0.006 17.1 0.5 4.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83673.1 - 1.8e-09 37.0 0.3 0.0031 17.9 0.0 5.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFA83673.1 - 6.4e-09 35.9 2.8 3.4e-05 24.0 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA83673.1 - 4.7e-06 26.8 0.1 0.00011 22.5 0.0 3.2 4 0 0 4 4 4 1 Ankyrin repeat PDR_CDR PF06422.12 EFA83673.1 - 1.7 8.6 6.6 1.3 9.0 1.0 2.9 2 0 0 2 2 2 0 CDR ABC transporter TPR_17 PF13431.6 EFA83674.1 - 2.1e-130 416.1 45.8 1.8e-10 40.4 0.4 15.4 15 0 0 15 15 15 15 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83674.1 - 1.1e-24 85.8 55.6 0.0019 17.9 0.3 14.5 14 0 0 14 14 14 11 TPR repeat TPPII_N PF12583.8 EFA83674.1 - 0.023 15.3 0.2 0.2 12.2 0.0 2.6 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal TPR_8 PF13181.6 EFA83674.1 - 1.4 9.3 25.2 84 3.8 0.0 12.2 17 0 0 17 17 17 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA83674.1 - 2.1 8.3 32.5 7.9 6.5 0.2 9.6 10 0 0 10 10 10 0 Tetratricopeptide repeat TMEM131_like PF12371.8 EFA83674.1 - 3.6 7.9 9.3 21 5.4 0.1 6.0 5 2 2 7 7 7 0 Transmembrane protein 131-like Ank_2 PF12796.7 EFA83675.1 - 9.4e-27 93.4 0.2 3.9e-08 33.8 0.0 5.8 3 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83675.1 - 6e-24 84.1 3.7 7.8e-06 26.3 0.0 9.2 10 0 0 10 10 10 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83675.1 - 2.1e-22 78.9 4.3 0.00011 22.4 0.1 9.7 6 3 4 10 10 10 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83675.1 - 7.2e-17 59.8 0.5 0.0059 17.0 0.0 11.1 12 0 0 12 12 12 2 Ankyrin repeat DUF3447 PF11929.8 EFA83675.1 - 1.1e-07 31.7 4.3 1.8 8.6 2.5 6.1 4 2 1 6 6 6 3 Domain of unknown function (DUF3447) Ank PF00023.30 EFA83675.1 - 0.0018 18.6 0.2 1.1 9.9 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 EFA83676.1 - 7e-17 61.6 6.5 8.3e-05 23.1 0.2 8.1 6 4 0 6 6 6 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83676.1 - 1.2e-14 54.6 0.3 0.011 16.3 0.0 5.9 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83676.1 - 6.5e-12 45.4 0.9 0.38 11.1 0.0 7.3 6 1 2 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83676.1 - 2.1e-11 43.0 0.1 15 6.6 0.0 10.0 10 0 0 10 10 10 1 Ankyrin repeat DUF3447 PF11929.8 EFA83676.1 - 0.002 18.1 8.4 0.13 12.3 0.1 5.6 3 2 3 6 6 6 1 Domain of unknown function (DUF3447) Sdh5 PF03937.16 EFA83676.1 - 0.21 11.6 2.3 0.41 10.6 0.2 2.7 3 0 0 3 3 3 0 Flavinator of succinate dehydrogenase LRR_4 PF12799.7 EFA83677.1 - 0.018 15.5 0.5 0.018 15.5 0.5 4.1 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Colicin_immun PF09204.10 EFA83677.1 - 0.023 15.2 0.0 0.08 13.5 0.0 1.9 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity AKNA PF12443.8 EFA83677.1 - 0.11 13.2 0.0 0.37 11.5 0.0 1.8 2 0 0 2 2 2 0 AT-hook-containing transcription factor VASP_tetra PF08776.11 EFA83677.1 - 0.36 10.4 2.7 1 9.0 2.7 1.8 1 0 0 1 1 1 0 VASP tetramerisation domain Med20 PF08612.11 EFA83681.1 - 5.9e-23 81.4 0.0 8.7e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex BRCT PF00533.26 EFA83681.1 - 0.058 13.8 0.1 0.089 13.2 0.1 1.6 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Ank_4 PF13637.6 EFA83682.1 - 6.6e-16 58.5 2.3 0.011 16.3 0.1 8.6 6 2 4 10 10 10 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83682.1 - 2e-15 57.1 4.0 0.00018 22.0 0.1 6.4 3 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83682.1 - 2.9e-13 49.7 1.6 0.043 14.1 0.0 9.6 9 1 2 11 11 11 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83682.1 - 1.1e-10 40.7 2.6 3.3 8.6 0.0 10.0 11 0 0 11 11 11 3 Ankyrin repeat DUF3447 PF11929.8 EFA83682.1 - 0.16 12.0 0.2 0.16 12.0 0.2 4.9 4 1 3 7 7 7 0 Domain of unknown function (DUF3447) CwfJ_C_2 PF04676.14 EFA83683.1 - 5.7e-24 84.9 0.5 5.7e-24 84.9 0.5 4.1 5 0 0 5 5 5 2 Protein similar to CwfJ C-terminus 2 DUF3439 PF11921.8 EFA83683.1 - 0.61 10.1 11.4 1.4 8.9 6.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EFA83683.1 - 2.9 7.9 24.3 7.3 6.6 17.0 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein CSRNP_N PF16019.5 EFA83684.1 - 1.5 8.7 11.9 1.2 9.0 10.4 1.5 1 1 1 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus Tyrosinase PF00264.20 EFA83684.1 - 3.4 7.9 9.6 4.1 7.6 9.6 1.1 1 0 0 1 1 1 0 Common central domain of tyrosinase HIP1_clath_bdg PF16515.5 EFA83684.1 - 6 7.5 21.3 0.48 11.1 8.2 2.3 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Ank_2 PF12796.7 EFA83685.1 - 7.6e-23 80.9 3.3 0.0015 19.1 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83685.1 - 4.8e-21 74.8 6.4 0.00025 21.5 0.1 8.7 6 1 4 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA83685.1 - 7.4e-12 45.3 6.8 0.18 12.2 0.0 7.8 5 3 3 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83685.1 - 8.1e-07 28.9 8.1 42 5.2 0.0 10.5 13 0 0 13 13 13 0 Ankyrin repeat DUF4411 PF14367.6 EFA83685.1 - 0.00085 19.3 0.3 0.35 10.8 0.0 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4411) Apis_Csd PF11671.8 EFA83687.1 - 1.1 9.3 8.5 1.9 8.5 8.5 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein Ank_5 PF13857.6 EFA83689.1 - 7.4e-19 67.6 5.4 0.0031 17.8 0.0 8.6 2 1 5 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83689.1 - 2.4e-18 66.5 5.8 1.8e-06 28.4 0.3 5.2 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83689.1 - 9.4e-15 54.8 4.6 0.016 15.8 0.1 6.2 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83689.1 - 3.4e-13 48.5 1.3 6.4 7.7 0.0 9.3 9 1 1 10 10 10 2 Ankyrin repeat Ank PF00023.30 EFA83689.1 - 0.00049 20.4 1.8 42 4.8 0.0 5.7 5 1 1 6 6 6 0 Ankyrin repeat Ank_5 PF13857.6 EFA83691.1 - 2.2e-21 75.6 9.9 0.00034 20.8 0.1 8.8 2 2 7 9 9 9 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83691.1 - 6.2e-21 74.8 7.6 6.9e-07 29.8 0.4 4.3 1 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83691.1 - 8.6e-20 70.9 9.4 0.00073 20.1 0.2 5.7 3 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83691.1 - 4.4e-12 45.1 2.5 5.7 7.9 0.0 8.9 8 1 1 9 9 9 3 Ankyrin repeat Ank PF00023.30 EFA83691.1 - 0.00017 21.9 2.4 44 4.8 0.2 5.9 2 1 4 6 6 6 0 Ankyrin repeat Dickkopf_N PF04706.12 EFA83692.1 - 0.016 15.7 4.7 0.016 15.7 4.7 5.6 3 2 2 5 5 5 0 Dickkopf N-terminal cysteine-rich region FSAP_sig_propep PF03032.15 EFA83693.1 - 0.0031 17.5 0.3 0.0071 16.4 0.3 1.7 1 1 0 1 1 1 1 Frog skin active peptide family signal and propeptide DUF2547 PF10818.8 EFA83693.1 - 0.0063 17.4 2.0 0.0063 17.4 2.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2547) RP-C_C PF11800.8 EFA83693.1 - 0.014 15.5 0.1 0.017 15.3 0.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region SUIM_assoc PF16619.5 EFA83693.1 - 0.035 14.2 6.6 0.046 13.8 6.6 1.4 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 WBP-1 PF11669.8 EFA83693.1 - 0.07 13.8 0.1 0.12 13.0 0.1 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 Ctr PF04145.15 EFA83693.1 - 0.12 13.0 0.0 0.18 12.4 0.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Beta_helix PF13229.6 EFA83694.1 - 1.6e-07 31.3 51.7 0.00016 21.5 23.5 3.9 2 1 2 4 4 4 3 Right handed beta helix region Chlam_PMP PF02415.17 EFA83694.1 - 0.00021 21.5 65.4 0.04 14.4 0.6 10.4 10 0 0 10 10 10 8 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Kelch_6 PF13964.6 EFA83695.1 - 2.8e-18 65.5 3.0 7e-07 29.3 0.1 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFA83695.1 - 8.6e-06 25.2 1.7 0.0038 16.8 0.4 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 EFA83695.1 - 4.6e-05 23.4 0.2 0.62 10.1 0.0 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain DUF5074 PF16819.5 EFA83695.1 - 0.00017 21.6 1.2 0.49 10.5 0.0 3.4 2 1 1 3 3 3 1 Domain of unknown function (DUF5074) zf-B_box PF00643.24 EFA83695.1 - 0.00033 20.7 20.8 0.00033 20.7 20.8 2.7 3 0 0 3 3 3 1 B-box zinc finger DUF4106 PF13388.6 EFA83695.1 - 0.018 14.3 0.7 0.018 14.3 0.7 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4106) Mlf1IP PF10248.9 EFA83695.1 - 0.64 10.0 6.6 2.2 8.2 5.7 2.3 2 1 0 2 2 2 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein Forkhead_N PF08430.12 EFA83695.1 - 1.2 9.8 35.0 2 9.0 35.0 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region SVWC PF15430.6 EFA83696.1 - 2.6e-07 30.8 5.1 2.9e-07 30.6 5.1 1.1 1 0 0 1 1 1 1 Single domain von Willebrand factor type C zf-RING_2 PF13639.6 EFA83698.1 - 3.1e-08 33.8 17.1 3.1e-08 33.8 17.1 3.3 3 1 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EFA83698.1 - 2.5e-05 24.5 16.6 2.5e-05 24.5 16.6 3.1 3 1 0 3 3 3 1 RING-H2 zinc finger domain ZZ PF00569.17 EFA83698.1 - 0.00025 20.8 11.4 0.00025 20.8 11.4 3.5 4 0 0 4 4 4 2 Zinc finger, ZZ type zf-RING_11 PF17123.5 EFA83698.1 - 4.3 7.2 20.6 0.12 12.1 12.6 2.7 2 1 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EFA83698.1 - 9.2 6.4 17.0 0.99 9.5 11.4 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger FNIP PF05725.12 EFA83699.1 - 7.9e-06 25.9 16.6 4.2e-05 23.6 0.0 4.9 5 1 0 5 5 5 2 FNIP Repeat FNIP PF05725.12 EFA83700.1 - 2.1e-22 79.0 35.3 2.4e-07 30.8 0.1 7.9 7 2 0 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA83700.1 - 9.6e-06 25.1 0.4 3.6e-05 23.2 0.4 1.9 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 EFA83700.1 - 0.0029 17.5 1.4 0.0066 16.3 0.5 2.0 2 0 0 2 2 2 1 F-box-like Ank_2 PF12796.7 EFA83701.1 - 9.5e-25 87.0 5.6 2.5e-05 24.8 2.0 7.2 3 1 6 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83701.1 - 1.4e-14 54.2 4.6 0.071 13.7 0.1 8.7 6 3 1 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83701.1 - 1.2e-10 40.6 21.0 1.1 10.0 0.2 11.9 11 1 1 12 12 12 3 Ankyrin repeat Ank_5 PF13857.6 EFA83701.1 - 3.3e-09 36.8 15.2 0.12 12.7 0.4 8.0 7 2 3 10 10 10 5 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA83701.1 - 0.0033 17.3 0.0 2.9 7.9 0.0 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF5049) DUF3447 PF11929.8 EFA83701.1 - 0.5 10.4 13.1 3.8 7.5 0.3 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA83703.1 - 0.00074 20.0 0.1 0.036 14.6 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) TPR_17 PF13431.6 EFA83704.1 - 1.6e-136 435.3 13.7 4.8e-10 39.1 0.1 14.2 14 0 0 14 14 14 14 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83704.1 - 6.5e-30 102.5 30.9 0.00028 20.5 0.1 12.7 13 0 0 13 13 13 10 TPR repeat CNOT1_CAF1_bind PF16415.5 EFA83704.1 - 0.00075 19.0 3.8 1.3 8.3 0.0 3.8 3 1 0 4 4 4 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Anth_Ig PF05587.13 EFA83704.1 - 0.0018 18.5 5.4 61 4.0 0.0 7.7 9 0 0 9 9 9 0 Anthrax receptor extracellular domain NleF_casp_inhib PF16809.5 EFA83704.1 - 0.0067 16.3 0.6 1.1e+02 2.6 0.0 6.8 5 3 3 9 9 9 0 NleF caspase inhibitor FlbD PF06289.11 EFA83704.1 - 0.012 15.2 0.2 0.22 11.1 0.2 3.3 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins P22_CoatProtein PF11651.8 EFA83704.1 - 0.015 13.9 0.5 15 4.0 0.0 4.1 3 2 2 5 5 5 0 P22 coat protein - gene protein 5 TPR_2 PF07719.17 EFA83704.1 - 0.016 15.3 29.0 31 5.0 0.0 12.1 16 0 0 16 16 13 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA83704.1 - 0.026 14.3 35.9 18 5.3 0.0 13.7 18 0 0 18 18 18 0 Tetratricopeptide repeat WW_FCH_linker PF16623.5 EFA83704.1 - 1.8 9.4 15.7 34 5.3 0.0 7.1 7 4 3 10 10 10 0 Unstructured linker region between on GAS7 protein DUF1966 PF09260.11 EFA83704.1 - 2.4 8.5 6.0 18 5.7 0.1 4.4 5 1 1 6 6 6 0 Domain of unknown function (DUF1966) TPR_8 PF13181.6 EFA83704.1 - 2.7 8.4 24.8 91 3.7 0.0 11.6 15 0 0 15 15 15 0 Tetratricopeptide repeat Peptidase_M20 PF01546.28 EFA83705.1 - 1.9e-32 112.6 0.0 2.3e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA83705.1 - 1.2e-17 63.8 0.0 8.6e-17 61.0 0.0 2.3 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFA83705.1 - 0.0025 17.5 0.0 0.029 14.1 0.0 2.1 1 1 0 2 2 2 1 Peptidase family M28 CbiN PF02553.15 EFA83706.1 - 0.13 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Cobalt transport protein component CbiN p31comet PF06581.12 EFA83708.1 - 0.00026 20.2 0.0 0.00045 19.5 0.0 1.4 1 0 0 1 1 1 1 Mad1 and Cdc20-bound-Mad2 binding DUF3899 PF13038.6 EFA83708.1 - 0.32 11.5 1.7 1.7 9.2 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF218 PF02698.17 EFA83709.1 - 2.7e-20 72.7 0.0 5.5e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 DUF218 domain ODV-E18 PF10717.9 EFA83709.1 - 0.01 15.7 1.4 0.028 14.3 1.4 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 SpoIIIAH PF12685.7 EFA83709.1 - 0.026 14.3 1.1 0.05 13.4 1.1 1.6 1 1 0 1 1 1 0 SpoIIIAH-like protein AA_kinase PF00696.28 EFA83709.1 - 0.042 13.4 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Amino acid kinase family Methyltransf_18 PF12847.7 EFA83709.1 - 0.1 12.6 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.32 EFA83710.1 - 2e-13 50.6 12.5 8.4e-05 23.3 0.3 6.4 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83710.1 - 1.4e-08 34.9 0.0 0.0023 18.2 0.0 3.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA83710.1 - 0.015 14.6 0.0 0.78 9.0 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain PD40 PF07676.12 EFA83710.1 - 0.025 14.5 0.1 3.4 7.7 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EFA83710.1 - 0.083 11.4 0.0 0.14 10.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain Kinesin PF00225.23 EFA83711.1 - 3.4e-111 371.4 2.4 3.4e-111 371.4 2.4 3.1 2 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFA83711.1 - 6.8e-27 94.2 0.3 2.6e-26 92.4 0.3 2.1 1 0 0 1 1 1 1 Microtubule binding Peptidase_C1 PF00112.23 EFA83712.1 - 2.1e-68 230.7 7.0 3.1e-68 230.1 7.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA83712.1 - 1.2e-14 54.5 4.2 2.5e-14 53.5 4.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA83712.1 - 2.3e-05 23.4 1.0 0.019 13.8 0.2 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Ibs_toxin PF13956.6 EFA83712.1 - 0.038 14.0 2.6 0.076 13.0 2.6 1.5 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system Notch PF00066.17 EFA83712.1 - 0.038 14.4 5.2 0.11 13.0 5.2 1.7 1 0 0 1 1 1 0 LNR domain CLU PF13236.6 EFA83715.1 - 1.3e-58 198.4 0.6 4.1e-58 196.8 0.0 2.1 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA83715.1 - 6.2e-06 26.4 1.6 6.2e-06 26.4 1.6 4.0 3 2 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 DUF4080 PF13311.6 EFA83716.1 - 0.083 13.1 2.8 0.19 11.9 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) FNIP PF05725.12 EFA83721.1 - 1.3e-37 127.6 26.4 1.1e-09 38.3 0.2 10.1 8 3 1 10 10 10 7 FNIP Repeat F-box_5 PF18511.1 EFA83721.1 - 2.8e-05 23.6 0.5 6.1e-05 22.5 0.5 1.5 1 0 0 1 1 1 1 F-box PIG-L PF02585.17 EFA83722.1 - 2.3e-05 25.0 0.0 5.7e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 GlcNAc-PI de-N-acetylase E1_DerP2_DerF2 PF02221.15 EFA83723.1 - 1.3e-18 67.7 0.2 1.7e-18 67.3 0.2 1.1 1 0 0 1 1 1 1 ML domain DUF4625 PF15418.6 EFA83723.1 - 0.01 16.1 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) TRP_N PF14558.6 EFA83723.1 - 0.017 15.5 0.3 0.046 14.1 0.3 1.7 1 1 0 1 1 1 0 ML-like domain E1_DerP2_DerF2 PF02221.15 EFA83724.1 - 9e-25 87.7 0.4 1e-24 87.5 0.4 1.0 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EFA83724.1 - 2e-05 25.0 0.1 3.8e-05 24.1 0.1 1.4 1 1 0 1 1 1 1 ML-like domain Fungus-induced PF10917.8 EFA83724.1 - 0.015 15.6 1.3 0.11 12.8 0.4 2.4 3 0 0 3 3 3 0 Fungus-induced protein E1_DerP2_DerF2 PF02221.15 EFA83725.1 - 4.7e-19 69.2 0.2 5.6e-19 68.9 0.2 1.0 1 0 0 1 1 1 1 ML domain Gp5_C PF06715.12 EFA83725.1 - 0.067 13.4 1.0 0.067 13.4 1.0 2.0 1 1 0 1 1 1 0 Gp5 C-terminal repeat (3 copies) Complex1_LYR PF05347.15 EFA83726.1 - 0.00041 20.3 0.2 0.0005 20.1 0.2 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) E1_DerP2_DerF2 PF02221.15 EFA83728.1 - 9.1e-24 84.4 0.5 1e-23 84.3 0.5 1.0 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EFA83728.1 - 1.2e-05 25.6 0.2 2.3e-05 24.8 0.2 1.4 1 1 0 1 1 1 1 ML-like domain DUF4625 PF15418.6 EFA83728.1 - 0.044 14.0 0.0 0.088 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) Nop14 PF04147.12 EFA83729.1 - 0.24 9.6 6.2 0.36 9.0 6.2 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 EFA83729.1 - 0.26 10.9 1.7 0.51 10.0 1.7 1.4 1 0 0 1 1 1 0 FAM176 family AF-4 PF05110.13 EFA83729.1 - 1 7.4 13.7 1.4 6.9 13.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BUD22 PF09073.10 EFA83729.1 - 5 6.3 15.5 0.68 9.2 11.4 1.5 2 0 0 2 2 2 0 BUD22 GalP_UDP_tr_C PF02744.17 EFA83730.1 - 0.0027 17.4 0.0 0.0046 16.7 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain p450 PF00067.22 EFA83731.1 - 8.6e-95 318.2 0.4 1e-94 317.9 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 LCM PF04072.14 EFA83732.1 - 1.2e-09 38.4 0.0 1.7e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase LCM PF04072.14 EFA83733.1 - 3.2e-08 33.7 0.0 3.9e-07 30.2 0.0 2.0 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase DUF5127 PF17168.4 EFA83733.1 - 0.02 14.7 0.1 0.025 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5127) HTH_Tnp_4 PF13613.6 EFA83734.1 - 1.2e-06 28.1 0.5 2.7e-06 27.0 0.5 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease YL1 PF05764.13 EFA83734.1 - 0.001 19.3 3.0 0.0013 18.9 3.0 1.2 1 0 0 1 1 1 1 YL1 nuclear protein BUD22 PF09073.10 EFA83734.1 - 0.0018 17.7 3.3 0.002 17.5 3.3 1.1 1 0 0 1 1 1 1 BUD22 CDC45 PF02724.14 EFA83734.1 - 0.0077 14.6 7.2 0.0099 14.2 7.2 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 EFA83734.1 - 0.032 12.5 8.2 0.039 12.2 8.2 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EFA83734.1 - 0.084 12.9 5.7 0.2 11.7 5.7 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.11 EFA83734.1 - 0.12 10.9 3.6 0.16 10.5 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pes-10 PF07149.11 EFA83734.1 - 0.16 11.0 5.1 0.079 12.0 2.7 1.6 2 0 0 2 2 2 0 Pes-10 Spt5_N PF11942.8 EFA83734.1 - 0.42 11.6 12.0 0.81 10.7 12.0 1.5 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PI3K_1B_p101 PF10486.9 EFA83734.1 - 0.48 8.1 2.6 0.6 7.8 2.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sigma70_ner PF04546.13 EFA83734.1 - 0.51 10.2 5.7 0.36 10.7 4.2 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region Pox_RNA_Pol_19 PF05320.12 EFA83734.1 - 0.69 9.9 7.3 1.3 9.0 7.3 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit NOA36 PF06524.12 EFA83734.1 - 1.4 8.2 15.5 2.1 7.6 15.5 1.3 1 0 0 1 1 1 0 NOA36 protein eIF-3c_N PF05470.12 EFA83734.1 - 1.9 6.7 8.1 2.7 6.2 8.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 EFA83734.1 - 7.8 4.5 14.9 11 4.0 14.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi YqfQ PF14181.6 EFA83734.1 - 9.2 6.4 6.9 14 5.9 6.9 1.2 1 0 0 1 1 1 0 YqfQ-like protein CENP-B_dimeris PF09026.10 EFA83734.1 - 9.4 6.7 16.6 26 5.3 16.6 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ketoacyl-synt PF00109.26 EFA83735.1 - 5.4e-78 262.1 0.0 9.8e-78 261.2 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA83735.1 - 1.1e-52 179.6 0.0 1.6e-52 179.0 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFA83735.1 - 7.7e-40 136.7 0.1 5.1e-38 130.8 0.0 2.7 2 0 0 2 2 2 1 KR domain Ketoacyl-synt_C PF02801.22 EFA83735.1 - 3.5e-39 133.5 0.1 1.9e-38 131.1 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Chal_sti_synt_N PF00195.19 EFA83735.1 - 1.8e-36 125.7 0.0 3e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain PS-DH PF14765.6 EFA83735.1 - 4.2e-34 118.1 0.0 6.5e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Chal_sti_synt_C PF02797.15 EFA83735.1 - 3.9e-22 78.9 0.0 9.3e-22 77.6 0.0 1.7 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain KAsynt_C_assoc PF16197.5 EFA83735.1 - 6.4e-19 68.5 0.0 2e-18 66.9 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA83735.1 - 2.6e-13 50.5 0.0 9.8e-13 48.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain FAE1_CUT1_RppA PF08392.12 EFA83735.1 - 6.3e-10 38.8 0.0 1.6e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Methyltransf_23 PF13489.6 EFA83735.1 - 4.5e-09 36.3 0.0 1.1e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EFA83735.1 - 1.9e-08 35.4 0.0 6.2e-08 33.8 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.25 EFA83735.1 - 5.3e-07 29.9 0.0 1.4e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_25 PF13649.6 EFA83735.1 - 7.2e-07 29.8 0.0 6.9e-06 26.7 0.0 2.9 2 0 0 2 2 1 1 Methyltransferase domain adh_short PF00106.25 EFA83735.1 - 3.5e-06 26.6 0.1 0.00023 20.7 0.0 2.9 3 0 0 3 3 3 1 short chain dehydrogenase Thiolase_N PF00108.23 EFA83735.1 - 9.8e-06 25.1 0.2 9.8e-06 25.1 0.2 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 EFA83735.1 - 2.5e-05 24.8 0.0 0.00015 22.4 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EFA83735.1 - 6.9e-05 22.7 0.0 0.00016 21.4 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase ACP_syn_III_C PF08541.10 EFA83735.1 - 0.00021 21.4 0.0 0.00099 19.2 0.0 2.3 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ADH_N PF08240.12 EFA83735.1 - 0.00022 21.1 0.0 0.00053 19.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.6 EFA83735.1 - 0.0019 18.0 0.0 0.0055 16.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Semialdhyde_dh PF01118.24 EFA83735.1 - 0.0072 16.8 0.0 0.15 12.5 0.0 2.5 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain ACP_syn_III PF08545.10 EFA83735.1 - 0.0085 15.9 0.2 0.0085 15.9 0.2 2.7 3 0 0 3 3 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ubie_methyltran PF01209.18 EFA83735.1 - 0.024 14.0 0.0 0.054 12.8 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.17 EFA83735.1 - 0.13 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Piwi PF02171.17 EFA83736.1 - 1.6e-77 260.7 0.9 2.6e-77 260.1 0.9 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EFA83736.1 - 1.6e-13 50.7 0.8 3.3e-13 49.6 0.8 1.5 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 EFA83736.1 - 1.7e-05 25.5 1.4 3e-05 24.7 0.2 2.1 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EFA83736.1 - 8.2e-05 22.2 0.0 0.00036 20.1 0.0 2.1 2 0 0 2 2 2 1 Argonaute linker 1 domain CortBP2 PF09727.9 EFA83736.1 - 0.07 13.0 0.5 3.3 7.6 0.1 2.4 1 1 0 2 2 2 0 Cortactin-binding protein-2 Cofilin_ADF PF00241.20 EFA83737.1 - 1.8e-58 195.6 0.0 8e-19 67.6 0.0 3.1 3 0 0 3 3 3 3 Cofilin/tropomyosin-type actin-binding protein Pkinase_Tyr PF07714.17 EFA83738.1 - 2.1e-29 102.6 0.0 3.2e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA83738.1 - 6.3e-18 65.1 0.0 1.3e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kelch_3 PF13415.6 EFA83738.1 - 1.9e-09 37.5 1.0 0.00071 19.8 0.1 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain RGS PF00615.19 EFA83738.1 - 3.1e-09 37.1 0.0 1e-08 35.5 0.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kelch_6 PF13964.6 EFA83738.1 - 5.2e-08 32.9 0.6 0.028 14.7 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFA83738.1 - 1.3e-07 31.4 0.2 0.0026 17.7 0.0 3.0 2 0 0 2 2 2 2 Kelch motif COR PF16095.5 EFA83738.1 - 2.6e-05 24.1 0.0 0.00034 20.5 0.0 2.7 2 1 0 2 2 2 1 C-terminal of Roc, COR, domain Kelch_4 PF13418.6 EFA83738.1 - 2.7e-05 24.1 1.3 0.068 13.2 0.1 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA83738.1 - 0.0043 16.6 0.1 0.53 9.9 0.0 2.6 2 0 0 2 2 2 1 Kelch motif DUF4667 PF15700.5 EFA83738.1 - 3.7 7.6 8.9 43 4.1 9.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) LRR_8 PF13855.6 EFA83739.1 - 1.5e-30 104.8 32.1 1.1e-09 37.8 2.6 5.3 5 0 0 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFA83739.1 - 4.4e-27 93.7 47.3 1.5e-06 28.4 8.6 7.7 4 2 4 9 9 9 8 Leucine Rich repeats (2 copies) RhoGAP PF00620.27 EFA83739.1 - 2.3e-16 60.0 3.0 5.9e-16 58.7 3.0 1.7 1 0 0 1 1 1 1 RhoGAP domain LRR_9 PF14580.6 EFA83739.1 - 8.1e-10 38.5 19.0 1.5e-05 24.6 0.7 4.1 1 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 EFA83739.1 - 2.8e-08 33.2 28.6 0.34 11.6 0.1 10.5 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.6 EFA83739.1 - 1.5 9.1 39.5 1.2 9.4 0.8 9.2 11 0 0 11 11 11 0 Leucine Rich repeat ATP-synt_10 PF05176.14 EFA83740.1 - 1.5e-47 162.0 0.1 1.7e-47 161.9 0.1 1.0 1 0 0 1 1 1 1 ATP10 protein Mucin PF01456.17 EFA83741.1 - 0.012 15.6 26.2 0.012 15.6 26.2 4.2 4 0 0 4 4 4 0 Mucin-like glycoprotein tRNA-synt_1c PF00749.21 EFA83742.1 - 7e-114 379.9 0.0 1.1e-113 379.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFA83742.1 - 4.2e-52 176.5 0.1 1.5e-51 174.8 0.1 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 EFA83742.1 - 2.6e-45 154.3 1.4 4.5e-45 153.6 1.4 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 PF04557.15 EFA83742.1 - 1.5e-12 48.2 1.5 1.5e-12 48.2 1.5 2.2 3 0 0 3 3 3 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 CAP PF00188.26 EFA83743.1 - 1e-15 58.7 0.3 2.2e-15 57.6 0.3 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ank_2 PF12796.7 EFA83744.1 - 5.4e-11 42.9 0.2 0.13 12.8 0.0 6.1 3 3 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83744.1 - 1.6e-10 41.3 0.1 0.098 13.3 0.0 6.2 5 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83744.1 - 1e-07 31.6 2.9 7.9 7.4 0.0 8.9 9 0 0 9 9 9 1 Ankyrin repeat CRIC_ras_sig PF10534.9 EFA83744.1 - 0.014 15.5 0.4 0.054 13.7 0.0 2.1 2 0 0 2 2 2 0 Connector enhancer of kinase suppressor of ras Terpene_synth_C PF03936.16 EFA83745.1 - 0.0024 17.3 0.0 0.004 16.5 0.0 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain EGF_2 PF07974.13 EFA83747.1 - 0.082 13.3 1.7 0.33 11.4 1.7 2.0 1 0 0 1 1 1 0 EGF-like domain Chlam_PMP PF02415.17 EFA83747.1 - 0.21 12.2 56.3 0.55 10.8 3.1 10.8 10 0 0 10 10 10 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat MRP-S26 PF14943.6 EFA83747.1 - 2.7 7.9 11.8 0.1 12.5 5.8 1.8 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 RIBIOP_C PF04950.12 EFA83748.1 - 3.1e-86 289.4 0.3 3.1e-86 289.4 0.3 3.1 3 0 0 3 3 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFA83748.1 - 5.2e-31 106.6 0.0 5.2e-31 106.6 0.0 3.1 3 0 0 3 3 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EFA83748.1 - 5e-07 29.5 2.9 4.5e-05 23.1 0.0 3.8 2 1 0 3 3 3 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA83748.1 - 1.1e-05 25.5 0.2 0.00021 21.3 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EFA83748.1 - 4.4e-05 23.7 0.0 0.00016 21.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFA83748.1 - 0.0049 17.3 0.0 0.016 15.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFA83748.1 - 0.0053 17.0 0.0 0.019 15.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EFA83748.1 - 0.0056 16.4 0.0 0.015 15.0 0.0 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EFA83748.1 - 0.013 16.0 3.8 0.039 14.5 0.0 3.4 3 0 0 3 3 3 0 ABC transporter AAA_16 PF13191.6 EFA83748.1 - 0.049 14.0 0.0 0.049 14.0 0.0 2.5 3 0 0 3 3 2 0 AAA ATPase domain FeoB_N PF02421.18 EFA83748.1 - 0.079 12.5 0.1 0.46 10.0 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA83748.1 - 0.17 11.8 4.1 0.6 10.0 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase SecE PF00584.20 EFA83749.1 - 2.4e-16 59.4 0.1 2.7e-16 59.2 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CbtB PF09489.10 EFA83749.1 - 0.089 12.9 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Actin PF00022.19 EFA83750.1 - 3.2e-30 105.1 12.3 1.1e-28 100.0 0.0 3.9 2 2 1 3 3 3 2 Actin Actin_micro PF17003.5 EFA83750.1 - 1.6e-05 24.3 1.1 0.00042 19.6 0.3 4.2 3 2 0 3 3 3 2 Putative actin-like family TFIIA PF03153.13 EFA83750.1 - 3.9 7.4 44.1 3.5 7.5 1.6 2.9 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit UBA PF00627.31 EFA83751.1 - 2.2e-13 49.8 0.2 2.2e-13 49.8 0.2 1.7 2 0 0 2 2 2 1 UBA/TS-N domain UBA_3 PF09288.10 EFA83751.1 - 0.039 13.8 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain E3_UbLigase_EDD PF11547.8 EFA83751.1 - 0.062 13.0 1.9 0.062 13.0 0.3 1.8 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD TALPID3 PF15324.6 EFA83751.1 - 0.29 8.8 3.0 0.39 8.3 3.0 1.1 1 0 0 1 1 1 0 Hedgehog signalling target Peptidase_C1 PF00112.23 EFA83752.1 - 2.7e-44 151.8 0.1 5.1e-44 151.0 0.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA83752.1 - 1.9e-14 53.8 2.4 3.5e-14 53.0 2.4 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Mucin PF01456.17 EFA83752.1 - 4.5 7.3 27.2 1.6 8.7 18.9 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein MMM1 PF10296.9 EFA83753.1 - 4.7e-11 42.3 1.3 2.7e-06 26.7 0.5 2.6 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 PAP1 PF08601.10 EFA83753.1 - 2.9 7.5 15.5 4.7 6.8 15.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Ribosomal_S30 PF04758.14 EFA83754.1 - 1.1e-25 89.6 8.2 1.2e-25 89.4 8.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 DUF1640 PF07798.11 EFA83755.1 - 0.013 15.5 2.7 0.027 14.5 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) UbiA PF01040.18 EFA83756.1 - 4.3e-25 88.5 16.7 6e-25 88.0 16.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family EGF_2 PF07974.13 EFA83757.1 - 0.00068 20.0 10.8 0.0016 18.8 10.8 1.7 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA83757.1 - 0.31 11.4 8.9 0.74 10.2 8.9 1.7 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA83759.1 - 0.00079 19.7 11.4 0.0017 18.7 11.4 1.6 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA83759.1 - 1 9.7 9.5 2 8.8 9.5 1.4 1 0 0 1 1 1 0 EGF-like domain Glyco_hydro_18 PF00704.28 EFA83760.1 - 1.4e-43 149.8 0.9 1.8e-43 149.4 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Thioredoxin PF00085.20 EFA83762.1 - 0.0044 17.0 0.1 0.0058 16.6 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFA83762.1 - 0.047 14.1 0.1 0.064 13.7 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain EGF_2 PF07974.13 EFA83764.1 - 0.0032 17.8 12.3 0.006 16.9 12.3 1.5 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA83764.1 - 0.023 15.0 8.3 0.044 14.1 8.3 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFA83764.1 - 0.053 13.6 5.9 0.14 12.3 5.9 1.7 1 0 0 1 1 1 0 Tenascin EGF domain Sec1 PF00995.23 EFA83765.1 - 7.5e-114 382.0 14.1 9.7e-114 381.7 14.1 1.1 1 0 0 1 1 1 1 Sec1 family RasGEF PF00617.19 EFA83765.1 - 0.0091 16.2 0.5 0.029 14.6 0.5 1.8 1 0 0 1 1 1 1 RasGEF domain CMS1 PF14617.6 EFA83765.1 - 0.015 14.7 2.3 0.042 13.2 2.3 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit SUIM_assoc PF16619.5 EFA83765.1 - 4.7 7.4 15.5 4.7 7.4 6.6 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Nup54 PF13874.6 EFA83766.1 - 0.0022 18.1 5.3 0.0064 16.6 4.7 2.1 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 zf-B_box PF00643.24 EFA83766.1 - 0.0089 16.2 10.8 0.019 15.1 10.8 1.6 1 0 0 1 1 1 1 B-box zinc finger OmpH PF03938.14 EFA83766.1 - 0.012 16.0 3.5 0.012 16.0 3.5 1.9 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3150 PF11348.8 EFA83766.1 - 0.2 10.8 5.3 0.14 11.3 1.2 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3150) Fzo_mitofusin PF04799.13 EFA83766.1 - 1.7 8.1 6.5 2.7 7.5 4.7 2.2 1 1 1 2 2 2 0 fzo-like conserved region OmpH PF03938.14 EFA83767.1 - 0.00097 19.5 0.7 0.00097 19.5 0.7 1.7 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) zf-B_box PF00643.24 EFA83767.1 - 0.0027 17.8 8.8 0.007 16.5 8.8 1.7 1 0 0 1 1 1 1 B-box zinc finger Apolipoprotein PF01442.18 EFA83767.1 - 0.031 14.1 0.0 0.078 12.8 0.0 1.7 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF4279 PF14106.6 EFA83767.1 - 0.14 12.4 3.4 0.56 10.4 0.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4279) Fzo_mitofusin PF04799.13 EFA83767.1 - 0.45 10.0 6.9 0.12 11.9 3.4 1.8 2 0 0 2 2 2 0 fzo-like conserved region Nup54 PF13874.6 EFA83767.1 - 2 8.5 9.9 0.24 11.5 2.0 3.0 3 1 0 3 3 3 0 Nucleoporin complex subunit 54 Exonuc_VII_L PF02601.15 EFA83767.1 - 3 7.3 12.4 1.8 8.0 9.8 1.8 1 1 1 2 2 2 0 Exonuclease VII, large subunit DLP_helical PF18709.1 EFA83767.1 - 5 6.2 15.4 1.1 8.4 10.6 2.1 1 1 0 2 2 2 0 Dynamin-like helical domain RasGEF PF00617.19 EFA83768.1 - 2.3e-56 190.8 2.7 3.3e-56 190.3 2.7 1.2 1 0 0 1 1 1 1 RasGEF domain DUF962 PF06127.11 EFA83769.1 - 0.043 13.9 0.3 0.11 12.6 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF962) MotB_plug PF13677.6 EFA83769.1 - 4.3 7.0 4.8 0.96 9.1 0.9 1.9 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB DUF5379 PF17350.2 EFA83770.1 - 0.042 14.1 1.1 0.21 11.9 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5379) FidL_like PF15941.5 EFA83770.1 - 0.1 13.1 1.1 1.3 9.5 0.1 2.1 2 0 0 2 2 2 0 FidL-like putative membrane protein Pkinase PF00069.25 EFA83771.1 - 4.7e-57 193.3 5.5 3.1e-39 134.9 0.0 2.8 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83771.1 - 1e-26 93.8 0.0 2.1e-15 56.7 0.0 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase FHA PF00498.26 EFA83771.1 - 1.1e-13 51.4 0.8 2.6e-13 50.1 0.0 2.1 2 0 0 2 2 2 1 FHA domain FHA_2 PF17913.1 EFA83771.1 - 0.0067 16.6 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 FHA domain MMR1 PF08505.10 EFA83771.1 - 0.22 11.8 20.9 0.41 10.9 20.9 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PUFD PF16553.5 EFA83771.1 - 0.27 11.4 3.4 0.85 9.8 3.4 1.8 1 0 0 1 1 1 0 BCORL-PCGF1-binding domain CCSAP PF15748.5 EFA83771.1 - 0.47 10.6 15.8 0.78 9.9 15.8 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Ndc1_Nup PF09531.10 EFA83771.1 - 5.2 5.6 8.6 7.9 5.0 8.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RCC1 PF00415.18 EFA83773.1 - 1.3e-44 150.5 4.8 1.2e-11 45.0 0.0 7.2 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA83773.1 - 4.6e-38 128.3 20.3 9.7e-10 38.0 0.3 6.5 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat CsgF PF10614.9 EFA83775.1 - 0.02 15.1 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 Type VIII secretion system (T8SS), CsgF protein CENP-S PF15630.6 EFA83776.1 - 2.2e-24 85.6 0.4 7.6e-24 83.9 0.4 2.0 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EFA83776.1 - 1.4e-06 28.3 1.2 3.7e-06 27.0 0.5 2.0 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold Dickkopf_N PF04706.12 EFA83778.1 - 0.0064 16.9 19.6 0.015 15.8 1.9 3.1 3 0 0 3 3 3 2 Dickkopf N-terminal cysteine-rich region DUF5332 PF17266.2 EFA83778.1 - 0.45 10.2 17.0 1.4 8.6 12.5 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5332) ATE_C PF04377.15 EFA83779.1 - 1.2e-46 158.6 3.9 1.2e-46 158.6 3.9 3.0 4 0 0 4 4 4 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EFA83779.1 - 4.4e-23 81.5 3.9 1.2e-22 80.0 3.9 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Mucin PF01456.17 EFA83779.1 - 0.55 10.2 18.0 0.092 12.7 11.6 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein P22_AR_C PF10548.9 EFA83780.1 - 0.018 15.2 0.1 0.072 13.3 0.0 2.0 2 0 0 2 2 2 0 P22AR C-terminal domain Vfa1 PF08432.10 EFA83781.1 - 0.0017 18.7 6.1 0.0032 17.8 6.1 1.5 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Indigoidine_A PF04227.12 EFA83781.1 - 0.033 13.6 0.6 0.058 12.7 0.6 1.3 1 0 0 1 1 1 0 Indigoidine synthase A like protein Orthopox_F14 PF06076.12 EFA83782.1 - 0.42 10.9 4.5 1.3 9.4 0.6 2.6 2 0 0 2 2 2 0 Orthopoxvirus F14 protein 4F5 PF04419.14 EFA83783.1 - 0.00022 22.0 6.8 0.00034 21.4 6.8 1.3 1 0 0 1 1 1 1 4F5 protein family zf-met PF12874.7 EFA83783.1 - 0.00068 19.9 1.9 0.0011 19.3 1.9 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-met2 PF12907.7 EFA83783.1 - 0.011 15.8 3.4 0.024 14.8 3.4 1.6 1 1 0 1 1 1 0 Zinc-binding zf-Di19 PF05605.12 EFA83783.1 - 0.15 12.3 2.1 0.28 11.5 2.1 1.4 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DHR-2 PF06920.13 EFA83784.1 - 4.1e-145 484.4 15.3 7.9e-145 483.5 15.3 1.4 1 0 0 1 1 1 1 Dock homology region 2 TyeA PF09059.10 EFA83784.1 - 0.015 15.4 0.1 0.04 14.0 0.1 1.7 1 0 0 1 1 1 0 TyeA DUF3398 PF11878.8 EFA83784.1 - 0.038 14.4 0.0 0.23 11.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3398) Acetyltransf_1 PF00583.25 EFA83785.1 - 2.8e-11 43.7 0.0 3.4e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA83785.1 - 1.6e-07 31.3 0.0 2.2e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA83785.1 - 2.3e-07 31.1 0.0 3.4e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA83785.1 - 2.7e-07 30.5 0.1 4.6e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein NMT PF01233.19 EFA83785.1 - 0.005 16.7 0.1 0.0082 16.0 0.1 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_CG PF14542.6 EFA83785.1 - 0.0069 16.5 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EFA83785.1 - 0.007 16.4 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA83785.1 - 0.01 16.5 0.0 0.012 16.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EFA83785.1 - 0.042 13.8 0.0 0.12 12.4 0.0 1.8 2 1 0 2 2 2 0 ESCO1/2 acetyl-transferase PanZ PF12568.8 EFA83785.1 - 0.056 13.2 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_15 PF17013.5 EFA83785.1 - 0.064 12.7 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase ECH_2 PF16113.5 EFA83786.1 - 6.3e-129 430.2 0.0 7.3e-129 430.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFA83786.1 - 6e-31 107.6 0.0 2.2e-29 102.5 0.0 2.1 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase FliG_N PF14842.6 EFA83786.1 - 0.0082 16.7 0.0 0.027 15.0 0.0 1.8 2 0 0 2 2 2 1 FliG N-terminal domain INTS2 PF14750.6 EFA83786.1 - 0.035 11.7 0.0 0.047 11.3 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 GlutR_dimer PF00745.20 EFA83786.1 - 0.08 13.4 0.2 4 8.0 0.0 3.1 4 0 0 4 4 4 0 Glutamyl-tRNAGlu reductase, dimerisation domain Amidohydro_2 PF04909.14 EFA83787.1 - 1.7e-11 44.4 0.0 3.1e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Lipase_3 PF01764.25 EFA83788.1 - 4.8e-27 94.6 0.0 7.1e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EFA83788.1 - 0.0035 18.0 0.0 0.0047 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 EFA83788.1 - 0.012 15.2 0.2 0.036 13.6 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) DUF676 PF05057.14 EFA83788.1 - 0.18 11.2 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) ArfGap PF01412.18 EFA83789.1 - 2.5e-28 98.5 0.1 2.5e-28 98.5 0.1 3.6 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EFA83789.1 - 0.0027 17.8 0.4 0.0075 16.4 0.4 1.8 1 0 0 1 1 1 1 B-box zinc finger AMP-binding PF00501.28 EFA83790.1 - 8e-91 304.7 0.0 1.5e-90 303.8 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme Peptidase_C1 PF00112.23 EFA83791.1 - 6.3e-57 193.1 3.6 1e-56 192.4 3.6 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA83791.1 - 1.9e-13 50.6 2.7 1.9e-13 50.6 2.7 2.4 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Beta-lactamase PF00144.24 EFA83792.1 - 2e-88 296.8 0.0 5.3e-44 150.8 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase Peptidase_S11 PF00768.20 EFA83792.1 - 0.0042 16.6 0.0 2.6 7.4 0.0 3.0 3 0 0 3 3 3 2 D-alanyl-D-alanine carboxypeptidase Ank_2 PF12796.7 EFA83793.1 - 0.00078 20.0 0.0 0.031 14.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) HTH_Tnp_1_2 PF13022.6 EFA83793.1 - 0.032 14.4 1.7 0.16 12.1 0.3 2.6 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase DUF3447 PF11929.8 EFA83793.1 - 2.9 7.9 9.9 2.7 8.0 0.5 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3447) Pkinase PF00069.25 EFA83794.1 - 1.7e-24 86.6 2.0 5.6e-24 84.9 2.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83794.1 - 5.9e-15 55.3 0.5 1.1e-14 54.3 0.5 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase ETRAMP PF09716.10 EFA83794.1 - 9.3 6.4 13.3 0.71 10.0 2.6 3.2 4 1 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) PHB_acc_N PF07879.11 EFA83795.1 - 0.14 12.3 2.3 9.3 6.4 0.5 2.5 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain DUF1768 PF08719.11 EFA83796.1 - 2.4e-29 102.7 0.2 2.7e-29 102.5 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Phage_30_3 PF08010.11 EFA83796.1 - 0.01 15.6 0.0 0.021 14.6 0.0 1.7 1 1 0 1 1 1 0 Bacteriophage protein GP30.3 LysM PF01476.20 EFA83798.1 - 6.9e-30 102.8 2.6 1.1e-06 28.5 0.0 4.2 4 0 0 4 4 4 4 LysM domain Copper-bind PF00127.20 EFA83798.1 - 2.4e-06 27.9 0.0 0.11 13.0 0.0 3.7 1 1 3 4 4 4 2 Copper binding proteins, plastocyanin/azurin family Prot_ATP_OB_N PF17758.1 EFA83798.1 - 0.002 17.7 0.0 17 5.2 0.0 4.2 4 0 0 4 4 4 1 Proteasomal ATPase OB N-terminal domain DUF5044 PF16447.5 EFA83798.1 - 0.0082 16.0 0.6 17 5.2 0.0 3.6 2 2 1 4 4 4 1 Domain of unknown function (DUF5044) Gp138_N PF18352.1 EFA83798.1 - 0.16 12.0 5.2 23 5.1 0.1 3.7 4 0 0 4 4 4 0 Phage protein Gp138 N-terminal domain PHZA_PHZB PF03284.13 EFA83798.1 - 2.2 7.9 6.0 30 4.2 0.1 3.6 4 0 0 4 4 4 0 Phenazine biosynthesis protein A/B NINJA_B PF16136.5 EFA83798.1 - 8.6 6.8 10.0 10 6.5 0.1 3.0 3 0 0 3 3 3 0 Putative nuclear localisation signal LysM PF01476.20 EFA83799.1 - 4.3e-15 55.5 0.0 2.7e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 LysM domain Copper-bind PF00127.20 EFA83799.1 - 0.035 14.5 0.0 0.56 10.7 0.0 2.0 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family DUF4379 PF14311.6 EFA83799.1 - 0.22 11.9 4.7 6.1 7.3 0.3 2.3 2 0 0 2 2 2 0 Probable Zinc-ribbon domain Cys_Knot_tox PF17486.2 EFA83799.1 - 0.47 10.7 5.5 3.5 7.9 0.6 2.4 2 0 0 2 2 2 0 Cystine knot toxins zf-B_box PF00643.24 EFA83800.1 - 1.6e-06 28.1 5.5 3e-06 27.3 5.5 1.4 1 0 0 1 1 1 1 B-box zinc finger DUF4194 PF13835.6 EFA83800.1 - 1.5 8.5 7.6 0.34 10.7 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4194) DUF406 PF04175.12 EFA83800.1 - 3.1 8.4 7.1 1.9 9.0 0.6 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF406) ECH_1 PF00378.20 EFA83801.1 - 2.3e-28 99.2 0.0 2.9e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFA83801.1 - 3.9e-12 46.3 0.0 4.9e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Kelch_6 PF13964.6 EFA83801.1 - 0.0014 18.8 0.1 0.0053 17.0 0.1 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EFA83801.1 - 0.18 11.8 2.2 1.3 9.1 0.2 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 EFA83801.1 - 0.4 10.7 3.0 1.6 8.8 0.5 3.0 2 1 0 2 2 2 0 Galactose oxidase, central domain RNA_pol_A_bac PF01000.26 EFA83802.1 - 1.1e-26 93.4 0.0 2.2e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFA83802.1 - 1.5e-24 85.2 0.0 3.1e-24 84.2 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 EFA83802.1 - 0.039 14.1 1.5 0.093 12.9 1.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain RNA_pol_L_2 PF13656.6 EFA83802.1 - 0.048 13.4 0.0 0.63 9.8 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_10 PF13237.6 EFA83802.1 - 0.062 13.4 1.1 0.16 12.1 1.1 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain DUF2284 PF10050.9 EFA83802.1 - 0.076 12.8 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) AAA PF00004.29 EFA83803.1 - 6.3e-17 62.2 0.0 1.2e-16 61.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EFA83803.1 - 4.5e-15 55.8 0.1 1.4e-14 54.3 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFA83803.1 - 1.1e-13 51.3 0.4 6.1e-10 39.1 0.0 2.9 2 1 1 3 3 3 2 DNA polymerase III, delta subunit Rad17 PF03215.15 EFA83803.1 - 4.5e-08 33.2 0.1 6.9e-07 29.4 0.0 2.4 2 1 0 2 2 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EFA83803.1 - 6.3e-06 26.4 0.0 1.4e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 EFA83803.1 - 2.9e-05 24.5 0.0 4.3e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EFA83803.1 - 4e-05 22.9 0.0 7.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFA83803.1 - 4.5e-05 23.8 0.0 0.028 14.7 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EFA83803.1 - 5.2e-05 22.8 0.0 9.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 EFA83803.1 - 0.00012 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFA83803.1 - 0.00012 21.8 0.0 0.00026 20.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EFA83803.1 - 0.00019 21.5 0.0 0.00044 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFA83803.1 - 0.00019 21.4 0.1 0.0011 18.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFA83803.1 - 0.00076 19.4 0.0 0.0017 18.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EFA83803.1 - 0.0011 18.8 0.0 0.0029 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFA83803.1 - 0.0019 17.9 0.0 0.0055 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EFA83803.1 - 0.0023 18.5 0.1 0.0039 17.7 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA83803.1 - 0.0026 18.1 0.0 0.031 14.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EFA83803.1 - 0.0032 17.2 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EFA83803.1 - 0.0037 17.8 0.0 0.012 16.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain DNA_pol3_delta PF06144.13 EFA83803.1 - 0.0066 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RNA_helicase PF00910.22 EFA83803.1 - 0.011 16.1 0.0 0.027 14.8 0.0 1.8 1 1 0 1 1 1 0 RNA helicase TniB PF05621.11 EFA83803.1 - 0.016 14.6 0.0 1.7 8.0 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 EFA83803.1 - 0.02 14.3 0.0 0.077 12.4 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFA83803.1 - 0.023 14.9 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFA83803.1 - 0.033 14.1 0.0 0.29 11.0 0.0 2.2 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea ResIII PF04851.15 EFA83803.1 - 0.048 13.7 0.0 0.35 10.8 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 EFA83803.1 - 0.056 14.0 0.0 0.15 12.5 0.0 1.9 2 1 0 2 2 1 0 ABC transporter Bac_DnaA PF00308.18 EFA83803.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.5 2 0 0 2 2 1 0 Bacterial dnaA protein TsaE PF02367.17 EFA83803.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFA83803.1 - 0.14 12.0 0.0 1.2 9.0 0.0 2.2 1 1 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 EFA83803.1 - 0.19 11.9 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ERG4_ERG24 PF01222.17 EFA83804.1 - 0.0079 15.0 0.6 0.012 14.4 0.6 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Clc-like PF07062.12 EFA83804.1 - 0.036 13.5 3.9 0.059 12.8 3.9 1.4 1 0 0 1 1 1 0 Clc-like OAD_gamma PF04277.13 EFA83804.1 - 0.066 13.8 0.3 1.3 9.6 0.0 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain ECSCR PF15820.5 EFA83804.1 - 0.96 9.3 7.3 0.99 9.3 0.4 2.5 2 1 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Tmemb_40 PF10160.9 EFA83804.1 - 2.6 7.4 11.4 0.037 13.5 3.8 1.6 2 0 0 2 2 2 0 Predicted membrane protein DUF1461 PF07314.11 EFA83804.1 - 4.8 7.0 9.7 1.8 8.5 3.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1461) Cation_ATPase_C PF00689.21 EFA83804.1 - 5.7 6.6 12.1 9.7 5.8 12.1 1.5 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus ubiquitin PF00240.23 EFA83805.1 - 1.4e-15 56.8 0.2 1.5e-15 56.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA83805.1 - 2e-07 30.7 0.5 2.2e-07 30.6 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2340 PF10209.9 EFA83805.1 - 0.016 15.6 1.2 0.02 15.4 1.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) Ubiquitin_4 PF18036.1 EFA83805.1 - 0.017 15.1 1.0 0.13 12.4 0.2 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain Peptidase_C1 PF00112.23 EFA83806.1 - 4.2e-60 203.5 2.9 6.1e-60 203.0 2.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA83806.1 - 2.9e-13 50.0 1.9 5e-13 49.3 1.9 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA83806.1 - 0.038 12.8 0.1 0.098 11.4 0.1 1.6 2 0 0 2 2 2 0 Peptidase C1-like family Peptidase_C13 PF01650.18 EFA83807.1 - 1.1e-39 136.6 0.1 1.8e-39 135.8 0.1 1.3 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 EFA83807.1 - 0.012 15.9 0.3 0.04 14.2 0.0 2.0 2 0 0 2 2 2 0 Mid domain of argonaute DUF2052 PF09747.9 EFA83808.1 - 0.56 10.3 15.9 0.088 12.9 8.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 EFA83808.1 - 1.9 7.8 14.6 0.072 12.5 7.7 1.9 2 0 0 2 2 2 0 SDA1 RPA43_OB PF17875.1 EFA83808.1 - 2 9.1 8.6 0.23 12.1 1.7 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DSPc PF00782.20 EFA83809.1 - 1.9e-30 105.4 0.1 2.7e-30 104.9 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA83809.1 - 0.00054 19.6 0.0 0.0009 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFA83809.1 - 0.01 16.0 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 EFA83809.1 - 0.034 13.8 0.1 0.056 13.1 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 EFA83809.1 - 0.055 13.1 0.1 0.092 12.3 0.1 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family SDA1 PF05285.12 EFA83810.1 - 5.4e-63 213.5 89.6 1.2e-34 120.4 28.2 3.2 2 1 1 3 3 3 3 SDA1 NUC130_3NT PF08158.12 EFA83810.1 - 5e-19 68.4 0.3 1.4e-18 66.9 0.3 1.9 1 0 0 1 1 1 1 NUC130/3NT domain WD40 PF00400.32 EFA83811.1 - 1.3e-13 51.2 7.7 3.9e-05 24.3 0.1 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Serglycin PF04360.12 EFA83811.1 - 0.004 17.1 0.9 0.004 17.1 0.9 2.4 2 0 0 2 2 2 1 Serglycin ETRAMP PF09716.10 EFA83811.1 - 0.19 11.8 3.5 0.4 10.8 0.7 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Alk_phosphatase PF00245.20 EFA83813.1 - 8.2e-88 295.1 1.2 1.2e-87 294.5 1.2 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EFA83813.1 - 6.1e-06 25.8 0.5 9e-06 25.2 0.5 1.5 1 1 0 1 1 1 1 Metalloenzyme superfamily Autoind_bind PF03472.15 EFA83813.1 - 0.032 13.7 0.0 2.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Autoinducer binding domain AAA_18 PF13238.6 EFA83814.1 - 2.6e-29 102.4 0.9 2.9e-29 102.2 0.2 1.4 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.6 EFA83814.1 - 9.7e-06 26.0 0.2 6.7e-05 23.3 0.0 2.2 1 1 1 2 2 2 1 AAA domain dNK PF01712.19 EFA83814.1 - 5.7e-05 23.1 6.5 0.067 13.0 3.4 2.1 1 1 0 2 2 2 2 Deoxynucleoside kinase AAA_28 PF13521.6 EFA83814.1 - 9.1e-05 22.8 0.5 0.00018 21.8 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFA83814.1 - 0.0004 20.6 0.1 0.21 11.8 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA PF00004.29 EFA83814.1 - 0.0011 19.4 0.0 0.0026 18.2 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EFA83814.1 - 0.0018 18.3 1.0 0.0069 16.4 1.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit RuvB_N PF05496.12 EFA83814.1 - 0.0066 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFA83814.1 - 0.014 15.7 0.3 0.044 14.0 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA83814.1 - 0.019 15.4 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ADK PF00406.22 EFA83814.1 - 0.021 15.0 1.2 2.7 8.1 0.0 2.8 1 1 1 2 2 2 0 Adenylate kinase SKI PF01202.22 EFA83814.1 - 0.021 15.0 1.9 0.17 12.0 1.9 2.2 1 1 0 1 1 1 0 Shikimate kinase AAA_5 PF07728.14 EFA83814.1 - 0.03 14.3 0.0 0.073 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EFA83814.1 - 0.033 14.5 0.2 0.038 14.3 0.2 1.6 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFA83814.1 - 0.036 14.0 0.8 0.14 12.1 0.1 2.1 1 1 1 2 2 2 0 NTPase AAA_24 PF13479.6 EFA83814.1 - 0.04 13.6 1.6 0.11 12.2 0.2 2.1 2 2 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFA83814.1 - 0.041 14.3 0.0 0.092 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.6 EFA83814.1 - 0.042 14.0 0.0 0.089 12.9 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EFA83814.1 - 0.074 12.8 0.0 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase PF06745.13 EFA83814.1 - 0.095 12.0 2.1 0.18 11.2 0.1 2.0 2 0 0 2 2 2 0 KaiC Zeta_toxin PF06414.12 EFA83814.1 - 0.1 11.9 0.3 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin T2SSE PF00437.20 EFA83814.1 - 0.19 10.7 0.1 0.19 10.7 0.1 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein zf-U1 PF06220.12 EFA83815.1 - 1.4e-19 69.5 3.6 1.9e-19 69.1 3.6 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.7 EFA83815.1 - 0.2 12.1 3.4 4.2 7.9 3.4 2.6 1 1 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFA83815.1 - 1.8 9.0 12.3 5.5 7.4 8.5 3.0 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding IBR PF01485.21 EFA83816.1 - 1.5e-10 41.2 38.2 6.7e-07 29.4 6.6 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFA83816.1 - 3.4e-06 26.8 3.0 3.4e-06 26.8 3.0 4.9 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA83816.1 - 3.6e-06 26.9 5.8 3.6e-06 26.9 5.8 4.1 4 1 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFA83816.1 - 0.00026 20.7 4.3 0.00026 20.7 4.3 5.3 5 1 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA83816.1 - 0.0048 17.2 7.8 0.0048 17.2 7.8 4.4 3 2 0 3 3 3 2 Ring finger domain zf-C3HC4_3 PF13920.6 EFA83816.1 - 0.011 15.5 5.4 0.011 15.5 5.4 4.9 3 2 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_S27e PF01667.17 EFA83816.1 - 6.5 6.5 8.6 25 4.7 0.1 3.1 2 0 0 2 2 2 0 Ribosomal protein S27 eIF2A PF08662.11 EFA83818.1 - 6.5e-62 208.9 0.1 1.8e-60 204.1 0.0 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Pyrophosphatase PF00719.19 EFA83819.1 - 4.1e-49 166.5 0.2 5e-49 166.2 0.2 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF3395 PF11875.8 EFA83820.1 - 2.7e-38 131.3 2.8 2.7e-38 131.3 2.8 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EFA83820.1 - 1.2e-21 76.6 3.0 2.7e-21 75.4 3.0 1.7 1 0 0 1 1 1 1 DnaJ domain Peptidase_S49 PF01343.18 EFA83821.1 - 4.8e-67 224.7 0.0 5.2e-43 146.6 0.0 2.7 3 0 0 3 3 3 2 Peptidase family S49 SDH_sah PF01972.16 EFA83821.1 - 0.0046 16.0 0.1 0.0085 15.1 0.1 1.4 1 0 0 1 1 1 1 Serine dehydrogenase proteinase DUF883 PF05957.13 EFA83821.1 - 0.017 15.7 0.0 0.22 12.2 0.0 2.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) CLP_protease PF00574.23 EFA83821.1 - 0.1 12.5 0.7 0.33 10.8 0.3 2.0 2 0 0 2 2 2 0 Clp protease SURF2 PF05477.11 EFA83822.1 - 2.6e-22 79.7 51.2 4e-20 72.5 51.2 2.4 1 1 0 1 1 1 1 Surfeit locus protein 2 (SURF2) RhoGAP PF00620.27 EFA83825.1 - 1.2e-31 109.6 0.3 3e-31 108.3 0.3 1.7 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.25 EFA83825.1 - 2.5e-18 66.4 0.1 1.5e-13 50.8 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83825.1 - 4.3e-11 42.6 0.0 7.1e-09 35.3 0.1 2.3 1 1 0 2 2 2 2 Protein tyrosine kinase PH PF00169.29 EFA83825.1 - 0.00068 20.1 0.6 0.0087 16.6 0.6 2.7 1 1 0 1 1 1 1 PH domain WD40 PF00400.32 EFA83826.1 - 4.5e-64 210.8 26.2 2.2e-09 37.8 0.8 9.1 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA83826.1 - 1.1e-23 83.3 3.3 0.00013 22.1 0.1 6.3 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EFA83826.1 - 7e-14 52.1 1.9 1.2e-13 51.3 1.9 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 EFA83826.1 - 9.7e-13 48.4 0.2 0.0046 16.9 0.0 4.2 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFA83826.1 - 6.4e-09 35.2 1.0 0.018 14.0 0.0 4.9 2 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFA83826.1 - 7.1e-08 31.5 2.8 0.64 8.6 0.0 4.8 4 1 1 5 5 5 4 Nucleoporin Nup120/160 Nbas_N PF15492.6 EFA83826.1 - 1.7e-05 24.3 0.3 0.086 12.2 0.0 3.9 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 EFA83826.1 - 0.00086 18.3 5.1 0.83 8.5 0.1 4.4 3 1 0 4 4 4 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 EFA83826.1 - 0.0032 16.9 0.0 8.9 5.5 0.0 3.6 4 0 0 4 4 4 1 WD40-like domain PD40 PF07676.12 EFA83826.1 - 0.0055 16.6 6.1 0.51 10.3 0.0 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 EFA83826.1 - 0.0097 15.0 0.1 0.81 8.7 0.0 2.4 2 0 0 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 EFA83826.1 - 0.018 13.6 0.0 0.29 9.6 0.0 2.5 2 1 1 3 3 3 0 Cytochrome D1 heme domain BBS2_Mid PF14783.6 EFA83826.1 - 0.11 12.5 0.0 16 5.6 0.0 3.5 4 0 0 4 4 3 0 Ciliary BBSome complex subunit 2, middle region Tim17 PF02466.19 EFA83827.1 - 9.7e-19 67.8 2.2 1.6e-18 67.1 1.9 1.5 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family MFS_MOT1 PF16983.5 EFA83827.1 - 0.052 13.9 0.2 0.1 13.0 0.2 1.6 1 1 0 1 1 1 0 Molybdate transporter of MFS superfamily EMP70 PF02990.16 EFA83828.1 - 1.5e-37 129.5 1.0 2.1e-25 89.4 0.5 2.2 2 0 0 2 2 2 2 Endomembrane protein 70 SelK_SelG PF10961.8 EFA83828.1 - 0.0084 16.7 0.6 0.0084 16.7 0.6 2.1 2 0 0 2 2 2 1 Selenoprotein SelK_SelG DUF3679 PF12438.8 EFA83828.1 - 0.41 10.4 2.5 0.76 9.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3679) FNIP PF05725.12 EFA83829.1 - 2.2e-33 114.2 26.5 1.1e-10 41.5 0.6 9.4 6 2 4 10 10 10 9 FNIP Repeat DUF1624 PF07786.12 EFA83830.1 - 1.9e-08 34.1 8.3 1.9e-08 34.1 8.3 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1624) DUF5009 PF16401.5 EFA83830.1 - 1.9e-06 27.6 1.0 1.9e-06 27.6 1.0 3.5 3 1 2 5 5 5 1 Domain of unknown function (DUF5009) Ank_4 PF13637.6 EFA83831.1 - 1.5e-16 60.5 5.2 0.0096 16.5 0.7 7.5 4 2 4 8 8 8 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83831.1 - 3.8e-14 53.0 1.8 0.0029 18.1 0.0 5.4 3 1 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83831.1 - 7.1e-13 48.5 2.1 0.17 12.2 0.0 7.5 5 1 3 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83831.1 - 3.2e-10 39.3 1.7 1.4 9.7 0.0 8.7 9 0 0 9 9 9 1 Ankyrin repeat DUF1843 PF08898.10 EFA83831.1 - 0.19 12.2 0.0 1.7 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Acyl_transf_1 PF00698.21 EFA83832.1 - 2e-30 106.4 0.2 4e-28 98.9 0.2 2.0 1 1 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 EFA83832.1 - 0.00081 19.2 0.1 0.0033 17.2 0.1 1.9 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Alba PF01918.21 EFA83832.1 - 0.09 12.6 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Alba Bac_surface_Ag PF01103.23 EFA83833.1 - 0.00042 19.9 0.1 0.00045 19.8 0.1 1.0 1 0 0 1 1 1 1 Surface antigen Pkinase PF00069.25 EFA83835.1 - 5.3e-65 219.4 0.1 8.2e-65 218.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA83835.1 - 1.3e-47 162.2 0.0 2e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA83835.1 - 6.6e-07 28.5 1.7 2.5e-06 26.5 1.7 1.9 1 1 0 1 1 1 1 Fungal protein kinase SH3_2 PF07653.17 EFA83835.1 - 6.1e-06 25.8 0.0 3.4e-05 23.4 0.0 2.3 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.28 EFA83835.1 - 6.6e-05 22.4 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Kinase-like PF14531.6 EFA83835.1 - 0.00012 21.5 0.0 0.001 18.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFA83835.1 - 0.0051 15.8 3.5 0.021 13.8 3.5 1.9 1 1 0 1 1 1 1 Haspin like kinase domain SH3_9 PF14604.6 EFA83835.1 - 0.0052 16.6 0.0 0.0097 15.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.23 EFA83835.1 - 0.0071 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFA83835.1 - 0.028 14.0 2.1 0.36 10.4 0.4 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFA83835.1 - 0.093 12.1 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Thymidylate_kin PF02223.17 EFA83836.1 - 2.8e-39 134.7 0.0 3.4e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase Myotub-related PF06602.14 EFA83837.1 - 3.2e-48 164.5 1.1 3.2e-48 164.5 1.1 2.3 2 1 1 3 3 3 1 Myotubularin-like phosphatase domain Ank_2 PF12796.7 EFA83838.1 - 4e-18 65.8 2.9 1.8e-09 38.1 0.2 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83838.1 - 6.7e-18 64.5 0.1 2.5e-05 24.4 0.0 4.2 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA83838.1 - 7e-16 58.4 1.6 0.012 16.2 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83838.1 - 9.9e-16 56.3 3.6 0.006 17.0 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EFA83838.1 - 7.6e-14 51.4 4.0 0.0016 18.8 0.2 5.4 5 0 0 5 5 5 3 Ankyrin repeat DUF3447 PF11929.8 EFA83838.1 - 0.0013 18.6 0.6 0.087 12.8 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3447) DUF2092 PF09865.9 EFA83838.1 - 0.0063 15.9 0.2 0.046 13.1 0.0 1.9 2 0 0 2 2 2 1 Predicted periplasmic protein (DUF2092) Glyco_hydro_18 PF00704.28 EFA83839.1 - 6.2e-63 213.4 6.4 7.8e-63 213.1 6.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DnaJ PF00226.31 EFA83840.1 - 1e-08 35.1 1.4 1.4e-08 34.7 1.4 1.2 1 0 0 1 1 1 1 DnaJ domain Holin_BhlA PF10960.8 EFA83840.1 - 0.039 13.9 0.1 0.9 9.6 0.4 2.1 2 0 0 2 2 2 0 BhlA holin family DUF4116 PF13475.6 EFA83841.1 - 0.13 12.1 2.2 1.1 9.0 0.1 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4116) Kelch_6 PF13964.6 EFA83843.1 - 4.7e-18 64.8 3.3 5.2e-06 26.5 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFA83843.1 - 4.5e-06 26.1 1.7 0.0003 20.3 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 EFA83843.1 - 1.1e-05 25.4 0.3 0.0008 19.4 0.1 3.0 2 1 0 2 2 2 1 Galactose oxidase, central domain SUIM_assoc PF16619.5 EFA83843.1 - 0.054 13.6 5.0 0.091 12.8 5.0 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Kelch_5 PF13854.6 EFA83843.1 - 0.65 10.1 11.0 0.59 10.2 0.2 4.1 4 0 0 4 4 4 0 Kelch motif PRANC PF09372.10 EFA83844.1 - 0.0083 16.4 4.6 0.015 15.6 1.5 3.1 1 1 1 2 2 2 1 PRANC domain FANCI_S2 PF14676.6 EFA83844.1 - 0.028 14.8 6.5 1.5 9.1 0.4 3.7 4 0 0 4 4 4 0 FANCI solenoid 2 DDE_Tnp_4 PF13359.6 EFA83845.1 - 0.0033 17.1 0.6 0.0047 16.6 0.4 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease KTI12 PF08433.10 EFA83846.1 - 2.4e-09 37.1 17.3 5.9e-05 22.6 10.3 3.4 2 2 1 3 3 3 2 Chromatin associated protein KTI12 PRANC PF09372.10 EFA83846.1 - 0.0019 18.5 4.6 0.0019 18.5 4.6 4.0 2 1 2 4 4 4 1 PRANC domain AAA_16 PF13191.6 EFA83846.1 - 0.033 14.6 0.1 0.87 9.9 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 EFA83846.1 - 0.054 13.5 0.6 0.054 13.5 0.6 3.0 2 1 2 4 4 4 0 AAA domain AAA_33 PF13671.6 EFA83846.1 - 0.24 11.6 0.1 0.24 11.6 0.1 2.4 3 2 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EFA83846.1 - 9.3 6.8 10.3 0.5 10.9 1.5 3.1 1 1 2 3 3 3 0 AAA domain V-SNARE_C PF12352.8 EFA83847.1 - 2.2e-07 31.0 1.4 2.2e-07 31.0 1.4 2.7 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFA83847.1 - 0.00013 21.8 1.6 0.00013 21.8 1.6 2.6 2 1 1 3 3 3 1 Sec20 DUF5089 PF17002.5 EFA83847.1 - 0.00093 19.1 1.4 0.00093 19.1 1.4 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF5089) MtrG PF04210.13 EFA83847.1 - 0.5 10.2 6.0 2 8.3 0.3 2.8 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF4140 PF13600.6 EFA83847.1 - 0.68 10.4 4.4 4.3 7.9 0.1 2.6 2 2 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) betaPIX_CC PF16523.5 EFA83847.1 - 2.1 8.2 13.0 0.89 9.4 4.1 2.8 2 2 0 2 2 2 0 betaPIX coiled coil DASH_Dam1 PF08653.10 EFA83847.1 - 3.9 7.4 8.0 5.3 6.9 0.4 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 Allexi_40kDa PF05549.11 EFA83847.1 - 5.7 6.4 12.4 4.6 6.7 4.6 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein PCRF PF03462.18 EFA83847.1 - 6.7 6.5 11.1 13 5.6 2.0 2.6 1 1 1 2 2 2 0 PCRF domain zf-RING_5 PF14634.6 EFA83848.1 - 2.7e-05 24.0 12.9 2.7e-05 24.0 12.9 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFA83848.1 - 0.0001 22.1 14.2 0.0001 22.1 14.2 2.6 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA83848.1 - 0.00014 21.6 14.3 0.00014 21.6 14.3 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA83848.1 - 0.00026 20.8 14.7 0.00026 20.8 14.7 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFA83848.1 - 0.0017 18.2 4.1 0.0017 18.2 4.1 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EFA83848.1 - 0.0021 18.3 14.3 0.0021 18.3 14.3 2.6 2 1 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA83848.1 - 0.003 17.6 8.0 0.003 17.6 8.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger U-box PF04564.15 EFA83848.1 - 0.05 13.8 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 U-box domain Cep57_CLD PF14073.6 EFA83848.1 - 0.059 13.4 10.5 0.082 12.9 10.5 1.1 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 Thiolase_N PF00108.23 EFA83849.1 - 1e-64 218.4 0.3 2.2e-64 217.3 0.3 1.5 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFA83849.1 - 8.7e-43 144.9 0.1 2e-42 143.7 0.1 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFA83849.1 - 0.00021 21.0 0.4 0.0027 17.3 0.2 2.6 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EFA83849.1 - 0.011 15.6 1.6 0.51 10.2 0.2 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ank_2 PF12796.7 EFA83850.1 - 1.8e-49 166.3 1.8 6.3e-11 42.7 0.0 5.5 4 2 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83850.1 - 2.6e-41 139.5 1.2 2.4e-06 28.0 0.0 10.5 3 3 8 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83850.1 - 5.4e-36 118.5 1.5 1.2e-06 28.3 0.0 11.1 12 0 0 12 12 12 6 Ankyrin repeat Ank_5 PF13857.6 EFA83850.1 - 1.4e-35 120.9 4.0 1.6e-10 41.0 0.0 7.0 7 1 2 9 9 9 4 Ankyrin repeats (many copies) Ank PF00023.30 EFA83850.1 - 6.5e-33 111.7 0.0 5.7e-05 23.4 0.0 9.8 10 1 0 10 10 10 4 Ankyrin repeat TTL PF03133.15 EFA83851.1 - 1.4e-23 83.5 4.4 1.6e-14 53.8 1.0 2.5 3 0 0 3 3 3 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFA83851.1 - 7.3e-09 35.3 0.0 0.00041 19.7 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFA83851.1 - 0.0034 16.7 0.0 0.0069 15.7 0.0 1.5 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp 5_nucleotid PF05761.14 EFA83853.1 - 9.9e-134 446.7 0.6 1.3e-133 446.3 0.6 1.0 1 0 0 1 1 1 1 5' nucleotidase family 5_nucleotid PF05761.14 EFA83854.1 - 1e-24 87.3 0.2 1e-24 87.3 0.2 1.0 1 0 0 1 1 1 1 5' nucleotidase family Coiled PF05710.12 EFA83856.1 - 0.0016 19.3 7.7 0.0018 19.0 7.7 1.1 1 0 0 1 1 1 1 Coiled coil GRP PF07172.11 EFA83856.1 - 0.36 11.6 29.1 0.57 10.9 29.1 1.3 1 0 0 1 1 1 0 Glycine rich protein family IBN_N PF03810.19 EFA83857.1 - 2.6e-07 30.4 3.9 2.6e-07 30.4 3.9 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 EFA83857.1 - 0.043 13.3 0.1 0.14 11.7 0.1 1.9 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat LysM PF01476.20 EFA83858.1 - 4.3e-31 106.7 7.7 0.00043 20.3 0.0 6.6 6 1 0 6 6 6 6 LysM domain DPBB_1 PF03330.18 EFA83858.1 - 2.8e-13 49.9 14.9 7.1e-13 48.6 0.0 5.7 4 2 2 6 6 6 1 Lytic transglycolase Prot_ATP_OB_N PF17758.1 EFA83858.1 - 1e-07 31.5 0.0 17 5.1 0.0 6.2 6 0 0 6 6 6 2 Proteasomal ATPase OB N-terminal domain Copper-bind PF00127.20 EFA83858.1 - 1.4e-05 25.5 0.0 17 5.9 0.0 5.0 4 1 1 5 5 5 1 Copper binding proteins, plastocyanin/azurin family Gp138_N PF18352.1 EFA83858.1 - 6.2e-05 23.0 10.8 16 5.7 0.0 6.2 6 0 0 6 6 6 2 Phage protein Gp138 N-terminal domain DUF4379 PF14311.6 EFA83858.1 - 3.2 8.2 31.5 13 6.2 0.6 5.9 6 0 0 6 6 6 0 Probable Zinc-ribbon domain FNIP PF05725.12 EFA83859.1 - 3.7e-15 55.8 14.4 9.4e-09 35.3 2.2 4.6 2 2 1 4 4 4 4 FNIP Repeat Kelch_6 PF13964.6 EFA83860.1 - 5.5e-10 39.2 7.4 2.1e-06 27.8 0.0 5.6 4 2 2 6 6 6 1 Kelch motif zf-B_box PF00643.24 EFA83860.1 - 9.2e-06 25.7 13.0 2.2e-05 24.5 13.0 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_5 PF13854.6 EFA83860.1 - 0.00027 20.8 1.7 0.39 10.7 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFA83860.1 - 0.00028 21.1 3.3 0.0066 16.7 0.0 3.4 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA83860.1 - 0.01 15.4 1.6 0.16 11.6 0.0 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 EFA83860.1 - 0.11 12.6 2.3 3.7 7.6 0.0 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA83860.1 - 0.15 12.1 0.1 1.9 8.6 0.0 3.0 2 0 0 2 2 2 0 Kelch motif ATP-grasp_2 PF08442.10 EFA83861.1 - 2.6e-75 252.4 1.4 4.4e-75 251.7 1.4 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EFA83861.1 - 2.8e-27 95.4 2.4 5.3e-27 94.5 2.4 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EFA83861.1 - 1.2e-10 41.2 0.5 2.1e-10 40.4 0.5 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFA83861.1 - 2.5e-05 24.2 0.6 5.7e-05 23.0 0.6 1.7 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp PF02222.22 EFA83861.1 - 0.036 13.6 0.0 0.081 12.5 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Peripla_BP_3 PF13377.6 EFA83861.1 - 0.056 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Periplasmic binding protein-like domain DAO_C PF16901.5 EFA83861.1 - 0.061 13.2 0.1 0.2 11.6 0.1 1.8 2 0 0 2 2 2 0 C-terminal domain of alpha-glycerophosphate oxidase RhoGEF PF00621.20 EFA83862.1 - 1e-49 169.3 3.5 3.6e-49 167.5 3.5 2.1 1 0 0 1 1 1 1 RhoGEF domain Arm PF00514.23 EFA83862.1 - 1.3e-25 88.5 9.2 2.2e-05 24.3 0.1 9.6 10 0 0 10 10 10 5 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 EFA83862.1 - 5.5e-12 45.7 18.3 0.00021 20.9 0.9 4.7 2 2 2 4 4 4 3 Armadillo-like KAP PF05804.12 EFA83862.1 - 5.9e-06 24.7 9.3 4.9e-05 21.7 2.2 4.4 3 2 1 5 5 5 2 Kinesin-associated protein (KAP) HEAT_EZ PF13513.6 EFA83862.1 - 0.0034 17.8 12.6 0.31 11.6 0.0 5.4 4 1 1 5 5 5 2 HEAT-like repeat HEAT PF02985.22 EFA83862.1 - 1.5 9.3 12.3 8.1 7.0 0.0 5.8 7 0 0 7 7 7 0 HEAT repeat RskA PF10099.9 EFA83862.1 - 6.9 6.9 9.6 83 3.4 9.7 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA MIR PF02815.19 EFA83863.1 - 5.4e-19 68.8 1.0 1.2e-15 57.8 0.2 2.5 1 1 1 2 2 2 2 MIR domain PilJ_C PF18223.1 EFA83863.1 - 0.056 14.0 0.0 0.18 12.3 0.0 1.9 2 0 0 2 2 2 0 Pili PilJ C-terminal domain GFA PF04828.14 EFA83865.1 - 0.0063 16.8 0.6 0.0063 16.8 0.6 1.8 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Phage_holin_3_6 PF07332.11 EFA83867.1 - 3.4 7.8 6.6 8.8 6.4 6.6 1.8 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RRP14 PF15459.6 EFA83870.1 - 0.16 12.6 3.2 0.31 11.7 3.2 1.4 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 PDEase_I PF00233.19 EFA83871.1 - 6e-53 180.0 4.0 6e-53 180.0 4.0 2.5 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.24 EFA83871.1 - 2.6e-25 88.8 1.1 5.3e-25 87.8 1.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain FliG_N PF14842.6 EFA83871.1 - 0.023 15.2 1.8 0.4 11.2 0.6 3.0 3 0 0 3 3 3 0 FliG N-terminal domain HD PF01966.22 EFA83871.1 - 0.056 13.7 1.5 0.21 11.8 0.0 2.3 2 1 0 2 2 2 0 HD domain CCDC24 PF15669.5 EFA83871.1 - 0.66 9.8 16.6 2.1 8.2 0.4 3.3 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 24 family RNB PF00773.19 EFA83872.1 - 2.7e-101 339.2 0.0 2.7e-101 339.2 0.0 2.1 3 0 0 3 3 3 1 RNB domain OB_Dis3 PF17849.1 EFA83872.1 - 1.6e-18 66.5 0.0 6.9e-18 64.5 0.0 2.2 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 EFA83872.1 - 2.6e-06 27.2 1.2 4e-06 26.6 0.1 1.9 2 0 0 2 2 2 1 Rrp44-like cold shock domain Dis3l2_C_term PF17877.1 EFA83872.1 - 3.8e-05 23.9 0.1 3.8e-05 23.9 0.1 4.2 4 0 0 4 4 4 1 DIS3-like exonuclease 2 C terminal DUF3439 PF11921.8 EFA83872.1 - 0.0065 16.4 1.2 0.0065 16.4 1.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) Rrp44_S1 PF17215.3 EFA83872.1 - 0.085 12.8 0.1 0.36 10.8 0.1 2.0 2 0 0 2 2 2 0 S1 domain SPRY PF00622.28 EFA83874.1 - 2.1e-14 53.7 3.0 9.9e-07 28.9 0.1 3.6 3 0 0 3 3 3 2 SPRY domain PHD PF00628.29 EFA83874.1 - 3.7e-06 26.7 5.2 8.5e-06 25.6 5.2 1.7 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EFA83874.1 - 0.0018 18.3 2.0 0.0076 16.3 2.0 2.1 1 0 0 1 1 1 1 PHD-finger Zn_ribbon_17 PF17120.5 EFA83874.1 - 0.016 14.8 0.9 0.036 13.7 0.9 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 EFA83874.1 - 0.98 9.4 6.7 0.2 11.6 2.8 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Senescence PF06911.12 EFA83875.1 - 1.5e-29 103.6 7.3 1.5e-29 103.6 7.3 2.5 3 0 0 3 3 3 1 Senescence-associated protein PH PF00169.29 EFA83875.1 - 2.7e-07 31.0 1.1 1.8e-06 28.4 0.0 2.9 3 0 0 3 3 3 1 PH domain CPSF_A PF03178.15 EFA83875.1 - 0.0091 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 CPSF A subunit region ketoacyl-synt PF00109.26 EFA83876.1 - 2.5e-73 246.8 0.0 4.3e-73 246.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain NAD_binding_4 PF07993.12 EFA83876.1 - 1.8e-50 171.5 0.0 5.9e-50 169.8 0.0 2.0 1 0 0 1 1 1 1 Male sterility protein Acyl_transf_1 PF00698.21 EFA83876.1 - 4e-45 154.7 0.0 1.1e-44 153.2 0.0 1.8 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA83876.1 - 6.6e-40 135.8 0.1 2.1e-39 134.2 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA83876.1 - 3.1e-34 118.4 0.0 3.3e-33 115.1 0.1 2.3 2 0 0 2 2 2 1 KR domain PseudoU_synth_2 PF00849.22 EFA83876.1 - 1.1e-26 93.9 0.1 1.1e-26 93.9 0.1 3.2 4 0 0 4 4 3 1 RNA pseudouridylate synthase PS-DH PF14765.6 EFA83876.1 - 2.1e-23 83.0 0.0 3.6e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA83876.1 - 4.3e-15 56.1 0.5 3.3e-14 53.3 0.2 2.8 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EFA83876.1 - 4.3e-10 40.8 0.0 1.9e-09 38.7 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Thiolase_N PF00108.23 EFA83876.1 - 7.8e-08 32.0 0.0 1.9e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain PP-binding PF00550.25 EFA83876.1 - 2.1e-07 31.2 0.0 1.1e-06 28.9 0.0 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EFA83876.1 - 1.6e-06 27.3 0.4 1.9e-05 23.8 0.4 2.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ADH_N PF08240.12 EFA83876.1 - 0.00013 21.8 0.0 0.00033 20.5 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 EFA83876.1 - 0.00014 21.4 0.0 0.00034 20.2 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 EFA83876.1 - 0.046 13.3 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Ca_bind_SSO6904 PF18249.1 EFA83876.1 - 0.15 12.4 2.6 0.45 10.9 0.2 3.3 3 0 0 3 3 2 0 Calcium binding protein SSO6904 Dimerisation2 PF16864.5 EFA83877.1 - 0.039 13.9 0.0 0.08 12.9 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain Ank_2 PF12796.7 EFA83878.1 - 0.016 15.8 0.0 4 8.1 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) zf-C3H1 PF10650.9 EFA83879.1 - 0.34 10.7 2.6 0.75 9.6 2.6 1.5 1 0 0 1 1 1 0 Putative zinc-finger domain Myotub-related PF06602.14 EFA83882.1 - 8.6e-139 462.4 0.1 8.6e-139 462.4 0.1 1.9 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain FERM_f0 PF16511.5 EFA83882.1 - 2.3e-18 66.2 4.1 6.4e-07 29.6 0.2 3.7 3 0 0 3 3 3 3 N-terminal or F0 domain of Talin-head FERM GRAM PF02893.20 EFA83882.1 - 6.9e-05 22.7 0.3 0.00025 20.9 0.3 2.0 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.20 EFA83882.1 - 0.00032 20.5 0.0 0.00032 20.5 0.0 2.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA83882.1 - 0.0013 18.4 0.0 0.0013 18.4 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFA83882.1 - 0.031 14.2 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family FERM_N PF09379.10 EFA83882.1 - 0.83 9.6 8.3 12 6.0 0.1 4.1 4 0 0 4 4 4 0 FERM N-terminal domain Solute_trans_a PF03619.16 EFA83883.1 - 3e-99 331.9 19.3 3.6e-99 331.6 19.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha COX7C PF02935.16 EFA83884.1 - 0.00047 20.4 0.0 0.00063 20.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Vinculin PF01044.19 EFA83885.1 - 4.2e-40 137.9 54.2 4.1e-18 65.1 24.1 4.7 1 1 2 4 4 4 4 Vinculin family SpoIIID PF12116.8 EFA83885.1 - 0.024 14.7 3.9 0.36 11.0 0.1 3.5 3 0 0 3 3 3 0 Stage III sporulation protein D DUF1110 PF06533.12 EFA83885.1 - 0.037 14.0 0.4 0.037 14.0 0.4 4.5 4 2 2 6 6 6 0 Protein of unknown function (DUF1110) P53_C PF11619.8 EFA83885.1 - 0.067 13.3 11.2 0.42 10.7 0.5 4.4 3 1 1 4 4 4 0 Transcription factor P53 - C terminal domain TSP_NTD PF17804.1 EFA83885.1 - 0.099 12.9 2.6 11 6.2 0.9 3.8 1 1 1 2 2 2 0 Tail specific protease N-terminal domain Cas_DxTHG PF09455.10 EFA83885.1 - 0.59 9.7 11.4 0.13 11.8 0.9 3.1 1 1 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family DUF948 PF06103.11 EFA83885.1 - 0.62 10.4 23.8 1.1 9.6 0.2 7.8 6 1 2 8 8 8 0 Bacterial protein of unknown function (DUF948) I_LWEQ PF01608.17 EFA83885.1 - 1.7 8.8 48.5 0.041 14.1 3.3 7.0 5 2 2 7 7 7 0 I/LWEQ domain Endotoxin_C2 PF18449.1 EFA83885.1 - 1.8 8.9 11.7 51 4.3 0.1 5.6 4 0 0 4 4 4 0 Delta endotoxin FUSC PF04632.12 EFA83885.1 - 4.5 5.7 15.1 0.64 8.5 4.2 2.5 2 1 0 2 2 2 0 Fusaric acid resistance protein family Syntaxin_2 PF14523.6 EFA83885.1 - 6.5 7.2 25.3 4 7.9 2.2 5.9 2 2 4 6 6 6 0 Syntaxin-like protein ALAD PF00490.21 EFA83886.1 - 2.8e-120 401.3 0.0 4.7e-120 400.5 0.0 1.3 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase GRAM PF02893.20 EFA83886.1 - 1.2e-14 54.1 0.3 2.8e-14 53.0 0.3 1.6 1 0 0 1 1 1 1 GRAM domain V-SNARE_C PF12352.8 EFA83886.1 - 4.1e-08 33.4 7.2 1.2e-06 28.7 1.3 2.7 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus SNARE PF05739.19 EFA83886.1 - 1.6e-05 24.8 5.5 0.00031 20.7 0.4 2.6 2 0 0 2 2 2 2 SNARE domain Perilipin PF03036.16 EFA83886.1 - 0.14 11.2 1.8 4.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Perilipin family DUF5089 PF17002.5 EFA83886.1 - 0.29 11.0 12.8 0.097 12.5 4.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) NPV_P10 PF05531.12 EFA83886.1 - 0.37 11.3 4.3 22 5.6 0.1 3.1 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EFA83886.1 - 0.49 10.5 3.9 12 6.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EFA83886.1 - 2.9 8.1 5.9 13 5.9 0.2 3.2 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.6 EFA83886.1 - 9.9 6.7 9.0 8.1 6.9 0.5 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Cpn60_TCP1 PF00118.24 EFA83887.1 - 6.9e-87 292.1 14.8 1.5e-86 291.0 14.8 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Hist_deacetyl PF00850.19 EFA83888.1 - 2.7e-90 302.9 0.0 4.5e-90 302.2 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain V-SNARE_C PF12352.8 EFA83888.1 - 0.0019 18.5 0.3 0.04 14.2 0.2 2.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Zn_Tnp_IS1 PF03811.13 EFA83888.1 - 0.024 14.4 2.4 0.047 13.4 2.4 1.5 1 0 0 1 1 1 0 InsA N-terminal domain Mod_r PF07200.13 EFA83888.1 - 0.044 13.9 0.9 0.17 12.0 0.9 2.1 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein RVT_1 PF00078.27 EFA83891.1 - 0.0031 17.1 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_C1 PF00112.23 EFA83892.1 - 2.2e-49 168.5 6.2 3.4e-49 167.9 6.2 1.3 1 0 0 1 1 1 1 Papain family cysteine protease CAP PF00188.26 EFA83892.1 - 6.4e-09 36.7 4.3 1.4e-08 35.6 4.3 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C1_2 PF03051.15 EFA83892.1 - 1.3e-05 24.2 2.0 0.003 16.4 0.3 2.5 3 0 0 3 3 3 2 Peptidase C1-like family LydB PF16084.5 EFA83892.1 - 0.021 14.6 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 LydA-holin antagonist MSA-2c PF12238.8 EFA83892.1 - 7.4 6.5 6.5 11 5.9 6.5 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c Inhibitor_I29 PF08246.12 EFA83893.1 - 2.8e-10 40.5 5.6 2.8e-10 40.5 5.6 2.8 2 2 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) PI3_PI4_kinase PF00454.27 EFA83895.1 - 5.6e-18 65.7 0.2 2.6e-11 43.8 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase Helicase_C_3 PF13625.6 EFA83895.1 - 0.069 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Helicase conserved C-terminal domain Nuf2 PF03800.14 EFA83896.1 - 0.0085 16.2 0.1 2.5 8.2 0.0 2.4 2 0 0 2 2 2 2 Nuf2 family DUF2552 PF10827.8 EFA83896.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2552) Ank_2 PF12796.7 EFA83897.1 - 1.5e-59 198.5 3.9 1.4e-14 54.4 0.1 5.2 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA83897.1 - 2.2e-39 133.4 0.1 9.3e-10 38.8 0.0 8.0 3 3 5 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83897.1 - 2.3e-38 125.8 0.2 1e-05 25.5 0.0 10.3 10 0 0 10 10 10 10 Ankyrin repeat Ank PF00023.30 EFA83897.1 - 5.1e-33 112.1 2.8 3.6e-06 27.2 0.1 10.1 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 EFA83897.1 - 1.8e-32 110.9 2.9 7.7e-07 29.3 0.0 8.8 1 1 8 10 10 10 9 Ankyrin repeats (many copies) DUF3898 PF13037.6 EFA83897.1 - 0.012 15.7 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3898) Defensin_2 PF01097.18 EFA83898.1 - 0.053 13.5 2.4 0.053 13.5 2.4 2.9 3 1 0 3 3 3 0 Arthropod defensin Peptidase_S8_N PF16361.5 EFA83900.1 - 0.034 14.6 0.0 0.044 14.3 0.0 1.1 1 0 0 1 1 1 0 N-terminal of Subtilase family Vezatin PF12632.7 EFA83901.1 - 1.7e-05 24.3 11.6 1.7e-05 24.3 11.6 2.7 3 1 1 4 4 4 1 Mysoin-binding motif of peroxisomes DUF4589 PF15252.6 EFA83901.1 - 0.019 15.0 1.4 0.019 15.0 1.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4589) TIR_2 PF13676.6 EFA83902.1 - 6.1e-19 68.8 0.2 5.4e-17 62.5 0.1 2.7 2 0 0 2 2 2 1 TIR domain RCC1_2 PF13540.6 EFA83902.1 - 8.1e-12 44.6 2.7 1.4e-06 27.9 0.1 3.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFA83902.1 - 4.2e-11 43.3 0.0 8.4e-06 26.3 0.0 3.7 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 EFA83902.1 - 2.6e-10 40.7 4.1 4.9e-06 27.0 0.5 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA83902.1 - 4e-08 33.4 2.6 0.0021 18.3 0.1 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA83902.1 - 4.9e-05 23.4 3.8 1.4 9.7 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFA83902.1 - 0.0001 22.6 2.7 0.0089 16.4 0.1 3.7 4 0 0 4 4 4 1 Ankyrin repeat TIR PF01582.20 EFA83902.1 - 0.00032 20.6 0.1 0.0016 18.2 0.0 2.1 2 0 0 2 2 2 1 TIR domain Ank_4 PF13637.6 EFA83902.1 - 0.0023 18.5 1.4 3.1 8.5 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) DUF2341 PF10102.9 EFA83902.1 - 0.066 13.8 1.2 0.36 11.5 1.2 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2341) DUF1863 PF08937.11 EFA83902.1 - 0.084 13.2 5.0 1.5 9.2 1.3 4.1 3 1 0 3 3 3 0 MTH538 TIR-like domain (DUF1863) Myb_DNA-binding PF00249.31 EFA83904.1 - 2.9e-30 104.2 3.8 1.5e-15 57.1 0.5 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA83904.1 - 2.6e-24 85.2 1.0 2.8e-16 59.5 0.2 3.4 2 1 1 3 3 3 2 Myb-like DNA-binding domain Adap_comp_sub PF00928.21 EFA83905.1 - 8.4e-87 290.9 0.1 1.2e-86 290.4 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family UQ_con PF00179.26 EFA83905.1 - 9.1e-49 164.7 0.1 1.6e-48 163.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Clat_adaptor_s PF01217.20 EFA83905.1 - 1.1e-09 38.4 1.5 1.9e-09 37.6 1.5 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EFA83905.1 - 0.053 13.0 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain LCM PF04072.14 EFA83906.1 - 2.6e-36 125.3 0.0 1.2e-35 123.2 0.0 2.2 3 1 0 3 3 3 1 Leucine carboxyl methyltransferase HopJ PF08888.11 EFA83907.1 - 0.023 14.9 0.0 0.032 14.5 0.0 1.3 1 1 0 1 1 1 0 HopJ type III effector protein LCM PF04072.14 EFA83909.1 - 8.2e-37 127.0 0.0 3e-36 125.1 0.0 2.1 3 1 0 3 3 3 1 Leucine carboxyl methyltransferase LCM PF04072.14 EFA83910.1 - 6.2e-37 127.4 0.0 5.1e-36 124.4 0.0 2.4 2 1 0 2 2 2 1 Leucine carboxyl methyltransferase TPR_14 PF13428.6 EFA83911.1 - 1.9e-16 59.3 3.5 0.64 11.0 0.2 9.1 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA83911.1 - 2.8e-07 31.1 1.2 0.00085 19.9 0.4 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA83911.1 - 4.9e-07 30.2 0.3 3 8.4 0.1 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat Suf PF05843.14 EFA83911.1 - 9.1e-07 29.1 37.8 0.002 18.2 0.2 6.4 5 2 0 5 5 5 3 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 EFA83911.1 - 1.8e-06 28.0 23.5 0.39 10.7 0.1 8.1 6 2 0 7 7 7 3 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 EFA83911.1 - 3.3e-06 27.3 12.8 0.24 11.7 0.1 5.2 6 1 1 7 7 4 3 Tetratricopeptide repeat TPR_15 PF13429.6 EFA83911.1 - 4.2e-06 26.2 15.7 0.097 11.9 0.2 5.6 4 3 2 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA83911.1 - 1.4e-05 24.9 11.4 0.68 10.2 0.1 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA83911.1 - 0.00054 20.0 10.3 0.23 11.8 0.2 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFA83911.1 - 0.021 14.7 6.8 0.31 11.0 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat SF3A3 PF16837.5 EFA83911.1 - 0.034 14.7 0.9 0.034 14.7 0.9 5.5 6 0 0 6 6 6 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 TPR_7 PF13176.6 EFA83911.1 - 0.039 14.0 6.0 0.56 10.4 0.1 5.2 5 1 0 5 5 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EFA83911.1 - 0.24 11.1 9.0 2.6 7.7 0.3 4.3 4 1 0 4 4 4 0 26S proteasome subunit RPN7 DUF2052 PF09747.9 EFA83911.1 - 0.42 10.7 12.2 0.87 9.7 12.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) HAT PF02184.16 EFA83911.1 - 1.2 9.2 12.4 1.2 9.2 0.1 5.9 7 0 0 7 7 5 0 HAT (Half-A-TPR) repeat TPR_1 PF00515.28 EFA83911.1 - 2.5 8.0 8.7 1.6 8.6 0.2 4.2 6 0 0 6 6 6 0 Tetratricopeptide repeat MMR_HSR1 PF01926.23 EFA83912.1 - 7.3e-12 45.4 0.2 1.8e-11 44.1 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA83912.1 - 5.4e-08 32.4 0.0 5.4e-08 32.4 0.0 1.8 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFA83912.1 - 1.1e-07 31.9 0.2 2.8e-07 30.6 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFA83912.1 - 8e-06 25.5 0.0 1.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 EFA83912.1 - 0.00047 20.7 1.8 0.0018 18.8 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 EFA83912.1 - 0.0011 19.5 0.6 0.39 11.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EFA83912.1 - 0.0021 18.5 2.0 0.0045 17.4 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFA83912.1 - 0.023 14.7 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PhoD PF09423.10 EFA83912.1 - 0.028 13.4 0.3 0.041 12.9 0.3 1.1 1 0 0 1 1 1 0 PhoD-like phosphatase YppF PF14178.6 EFA83912.1 - 0.037 13.9 1.7 6.1 6.8 0.0 2.9 3 0 0 3 3 3 0 YppF-like protein Dynamin_N PF00350.23 EFA83912.1 - 0.045 13.8 7.6 0.46 10.5 0.1 3.2 2 2 1 3 3 3 0 Dynamin family RNA_helicase PF00910.22 EFA83912.1 - 0.072 13.5 0.1 0.18 12.2 0.1 1.7 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 EFA83912.1 - 0.12 12.5 0.7 19 5.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFA83912.1 - 0.15 12.4 0.1 0.38 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain UPF0242 PF06785.11 EFA83912.1 - 0.3 11.2 10.2 0.41 10.7 10.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 EFA83912.1 - 0.91 10.2 6.8 0.75 10.5 4.6 1.9 1 1 1 2 2 2 0 Initiation control protein YabA AMP-binding PF00501.28 EFA83913.1 - 7.6e-59 199.4 0.0 1.1e-58 198.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFA83913.1 - 6.1e-57 192.7 0.0 9.8e-57 192.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFA83913.1 - 1.7e-09 37.5 0.0 3.2e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA83913.1 - 4.4e-06 25.9 0.3 1.6e-05 24.1 0.3 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFA83913.1 - 1.2e-05 24.9 0.1 2.2e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase PP-binding PF00550.25 EFA83913.1 - 5.5e-05 23.4 0.1 0.00012 22.3 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site RmlD_sub_bind PF04321.17 EFA83913.1 - 0.0013 17.8 0.3 0.0036 16.4 0.0 1.7 2 1 0 2 2 2 1 RmlD substrate binding domain Glyco_hydro_20 PF00728.22 EFA83914.1 - 4.7e-89 299.2 1.6 5.8e-89 298.9 1.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFA83914.1 - 4.5e-13 50.0 0.1 7.3e-12 46.1 0.1 2.5 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFA83914.1 - 0.00028 21.7 0.0 0.0006 20.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_20 PF00728.22 EFA83915.1 - 3.1e-82 276.8 0.7 4e-82 276.4 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFA83915.1 - 3.4e-11 44.0 1.2 1.7e-09 38.4 1.2 2.4 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFA83915.1 - 0.067 14.0 0.0 0.13 13.0 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 Pro_CA PF00484.19 EFA83917.1 - 7.1e-51 172.6 0.6 1.2e-50 171.9 0.0 1.6 2 0 0 2 2 2 1 Carbonic anhydrase DUF4727 PF15856.5 EFA83917.1 - 0.081 12.5 1.4 0.13 11.8 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4727) Foie-gras_1 PF11817.8 EFA83918.1 - 7.9e-38 130.5 0.5 1.6e-37 129.5 0.5 1.6 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun PF07919.12 EFA83918.1 - 1.4e-10 40.6 0.1 2.6e-07 29.8 0.0 2.6 2 0 0 2 2 2 2 Gryzun, putative trafficking through Golgi TRAPPC10 PF12584.8 EFA83918.1 - 0.00036 20.3 0.0 0.0076 16.0 0.0 2.6 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF5578 PF17741.1 EFA83918.1 - 0.0036 16.8 1.0 0.94 8.8 0.0 2.4 2 0 0 2 2 2 2 Family of unknown function (DUF5578) Gryzun-like PF12742.7 EFA83918.1 - 0.0049 16.9 0.0 0.017 15.1 0.0 2.0 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Ku_PK_bind PF08785.11 EFA83919.1 - 0.95 9.6 6.2 0.47 10.6 1.8 2.6 3 1 1 4 4 4 0 Ku C terminal domain like MatP_C PF17414.2 EFA83920.1 - 0.066 13.4 1.9 0.14 12.3 0.2 2.3 2 0 0 2 2 2 0 MatP C-terminal ribbon-helix-helix domain EMC3_TMCO1 PF01956.16 EFA83920.1 - 1.5 8.5 4.7 3.1 7.5 4.7 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like TMF_TATA_bd PF12325.8 EFA83920.1 - 8.3 6.7 14.1 0.33 11.2 0.7 2.9 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding MIF4G PF02854.19 EFA83921.1 - 1.6e-25 90.0 14.8 4.2e-25 88.6 7.4 2.9 2 0 0 2 2 2 2 MIF4G domain MCRS_N PF13325.6 EFA83922.1 - 3e-07 30.7 16.9 3.4e-06 27.2 13.4 3.7 2 1 0 2 2 2 1 N-terminal region of micro-spherule protein Phospholip_B PF04916.13 EFA83923.1 - 3.6e-164 547.3 5.3 4.5e-164 546.9 5.3 1.0 1 0 0 1 1 1 1 Phospholipase B Ras PF00071.22 EFA83924.1 - 2.1e-59 199.8 0.1 2.5e-59 199.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA83924.1 - 2.5e-33 114.9 0.1 4.5e-33 114.0 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83924.1 - 7.8e-13 48.3 0.0 1e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA83924.1 - 2.6e-05 24.3 0.1 6.7e-05 22.9 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFA83924.1 - 0.00017 21.2 0.1 0.006 16.1 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA83924.1 - 0.0011 18.4 0.0 0.0023 17.3 0.0 1.4 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFA83924.1 - 0.0013 18.6 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EFA83924.1 - 0.0064 15.9 0.0 0.021 14.2 0.0 1.8 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EFA83924.1 - 0.0086 15.8 0.1 0.03 14.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain RhoGAP PF00620.27 EFA83925.1 - 1.4e-34 119.2 0.2 3e-34 118.0 0.2 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EFA83925.1 - 3.4e-15 56.4 1.7 5.8e-07 30.0 0.0 3.2 2 1 1 3 3 3 2 PH domain ATP_bind_1 PF03029.17 EFA83927.1 - 3.6e-79 265.9 0.1 3.6e-79 265.9 0.1 1.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EFA83927.1 - 1.2e-07 31.5 0.1 0.00068 19.2 0.0 2.9 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 EFA83927.1 - 2.1e-07 30.5 0.0 0.00015 21.3 0.0 3.1 2 1 0 2 2 2 1 ADP-ribosylation factor family G-alpha PF00503.20 EFA83927.1 - 1.1e-05 24.8 0.2 1.1e-05 24.8 0.2 2.8 2 1 1 3 3 3 1 G-protein alpha subunit cobW PF02492.19 EFA83927.1 - 2.3e-05 24.1 0.0 0.061 12.9 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 EFA83927.1 - 0.00012 21.7 0.0 0.0056 16.2 0.0 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.6 EFA83927.1 - 0.00023 21.6 0.0 0.00044 20.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EFA83927.1 - 0.00057 19.9 0.0 0.0057 16.7 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EFA83927.1 - 0.0007 19.0 0.6 0.14 11.5 0.1 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 EFA83927.1 - 0.0012 18.8 2.0 0.4 10.6 0.0 3.2 4 0 0 4 4 3 1 RsgA GTPase NACHT PF05729.12 EFA83927.1 - 0.0015 18.5 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain SRP54 PF00448.22 EFA83927.1 - 0.0023 17.6 0.0 0.048 13.3 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EFA83927.1 - 0.0026 18.1 0.0 0.0071 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFA83927.1 - 0.0032 17.2 0.7 0.022 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFA83927.1 - 0.0035 16.6 0.5 0.0093 15.2 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 EFA83927.1 - 0.0039 16.9 0.0 0.0065 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.10 EFA83927.1 - 0.0044 16.5 0.0 0.19 11.2 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFA83927.1 - 0.0047 16.7 0.4 0.044 13.5 0.0 2.7 4 0 0 4 4 3 1 Ethanolamine utilisation - propanediol utilisation Pox_A32 PF04665.12 EFA83927.1 - 0.0053 16.2 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 Poxvirus A32 protein Zeta_toxin PF06414.12 EFA83927.1 - 0.0079 15.5 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin MeaB PF03308.16 EFA83927.1 - 0.0083 15.1 0.0 1.7 7.5 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EFA83927.1 - 0.0084 16.0 0.0 0.9 9.4 0.0 2.3 2 0 0 2 2 2 1 NTPase Roc PF08477.13 EFA83927.1 - 0.0088 16.2 0.0 0.11 12.7 0.0 2.7 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EFA83927.1 - 0.011 16.2 2.4 0.025 15.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFA83927.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA83927.1 - 0.019 15.5 0.4 0.19 12.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter KAP_NTPase PF07693.14 EFA83927.1 - 0.02 14.2 0.1 0.091 12.0 0.1 2.0 1 1 0 1 1 1 0 KAP family P-loop domain AAA_23 PF13476.6 EFA83927.1 - 0.029 14.9 7.1 4.4 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFA83927.1 - 0.03 14.3 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 EFA83927.1 - 0.057 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EFA83927.1 - 0.071 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 EFA83927.1 - 0.091 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFA83927.1 - 0.097 12.7 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFA83927.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFA83927.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 EFA83927.1 - 0.13 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein CSRNP_N PF16019.5 EFA83927.1 - 0.75 9.7 8.0 1.5 8.7 8.0 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus UPF0560 PF10577.9 EFA83927.1 - 1.7 7.1 9.9 2.3 6.6 9.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DTW PF03942.15 EFA83928.1 - 2.2e-22 79.8 0.0 4.7e-22 78.7 0.0 1.6 1 1 0 1 1 1 1 DTW domain zf-B_box PF00643.24 EFA83928.1 - 0.03 14.5 3.5 0.068 13.3 3.5 1.6 1 0 0 1 1 1 0 B-box zinc finger DisA-linker PF10635.9 EFA83929.1 - 0.0036 17.1 0.2 0.0054 16.5 0.2 1.3 1 0 0 1 1 1 1 DisA bacterial checkpoint controller linker region Ank_4 PF13637.6 EFA83930.1 - 7.2e-28 96.6 12.5 0.00096 19.7 0.1 10.6 8 4 1 9 9 9 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA83930.1 - 1.9e-26 92.4 5.8 2.1e-05 25.0 0.0 6.9 4 1 2 7 7 7 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA83930.1 - 4.4e-20 69.6 9.4 2.7 8.8 0.0 13.2 13 1 1 14 14 14 5 Ankyrin repeat Ank_5 PF13857.6 EFA83930.1 - 2.4e-16 59.6 9.3 2.8 8.3 0.0 11.8 8 4 5 13 13 13 5 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA83930.1 - 1e-10 41.4 8.4 0.023 14.6 0.0 6.3 4 2 2 6 6 6 3 Domain of unknown function (DUF3447) DUF249 PF03158.13 EFA83930.1 - 0.018 14.8 10.7 0.26 11.0 0.1 4.9 2 2 2 5 5 5 0 Multigene family 530 protein EF-hand_13 PF17958.1 EFA83933.1 - 3.4e-24 84.5 1.0 3.8e-22 77.9 0.1 3.8 3 1 1 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 EFA83933.1 - 9.4e-17 61.2 1.1 9.4e-17 61.2 1.1 3.5 4 1 1 5 5 5 1 EF-hand domain pair EF-hand_8 PF13833.6 EFA83933.1 - 0.0047 16.8 1.4 0.22 11.4 0.1 3.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EFA83933.1 - 0.017 15.0 3.3 0.84 9.7 0.3 3.8 4 0 0 4 4 4 0 EF-hand domain EF-hand_1 PF00036.32 EFA83933.1 - 0.038 13.5 5.9 0.76 9.5 0.1 4.5 5 1 1 6 6 6 0 EF hand Macoilin PF09726.9 EFA83933.1 - 0.14 10.6 12.0 0.21 10.1 12.0 1.1 1 0 0 1 1 1 0 Macoilin family STAT_bind PF02864.15 EFA83933.1 - 1.2 9.7 10.2 0.23 12.0 6.0 1.9 2 0 0 2 2 2 0 STAT protein, DNA binding domain SPARC_Ca_bdg PF10591.9 EFA83933.1 - 2.2 8.6 14.1 1.6 9.1 0.1 3.8 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region F_actin_bund_C PF18060.1 EFA83934.1 - 5e-20 71.4 3.7 1.1e-19 70.4 3.7 1.5 1 0 0 1 1 1 1 F actin bundling C terminal EF-hand_5 PF13202.6 EFA83934.1 - 0.03 13.8 0.0 0.081 12.5 0.0 1.7 1 0 0 1 1 1 0 EF hand PNK3P PF08645.11 EFA83935.1 - 1.5e-50 171.0 0.2 2.9e-50 170.1 0.0 1.6 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EFA83935.1 - 1.8e-16 60.6 0.1 9e-14 51.8 0.1 2.7 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFA83935.1 - 0.00016 21.0 0.1 0.022 14.0 0.1 2.6 2 1 1 3 3 3 1 Zeta toxin KTI12 PF08433.10 EFA83935.1 - 0.00066 19.2 0.2 0.22 10.9 0.1 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 Hydrolase_like PF13242.6 EFA83935.1 - 0.0048 16.9 0.0 0.023 14.8 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 EFA83935.1 - 0.026 14.6 1.2 2 8.5 0.0 3.3 3 1 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EFA83935.1 - 0.18 12.0 0.0 2.6 8.2 0.0 2.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Cpn60_TCP1 PF00118.24 EFA83936.1 - 4e-151 504.0 15.0 4.5e-151 503.8 15.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Adeno_IVa2 PF02456.15 EFA83936.1 - 0.054 12.3 0.2 0.09 11.6 0.2 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Peroxin-13_N PF04088.13 EFA83937.1 - 3.7e-19 69.5 2.1 3.7e-19 69.5 2.1 2.3 2 0 0 2 2 2 1 Peroxin 13, N-terminal region SH3_9 PF14604.6 EFA83937.1 - 4.5e-13 48.8 0.0 7.7e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA83937.1 - 2.8e-12 46.1 0.1 5.8e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA83937.1 - 8.8e-12 44.4 0.0 1.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain DUF3953 PF13129.6 EFA83937.1 - 0.25 11.1 2.0 0.53 10.1 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) DUF4834 PF16118.5 EFA83937.1 - 0.29 12.1 0.1 0.29 12.1 0.1 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Profilin PF00235.19 EFA83938.1 - 2e-44 150.9 0.0 2.2e-44 150.8 0.0 1.0 1 0 0 1 1 1 1 Profilin DGCR6 PF07324.11 EFA83939.1 - 0.00029 20.5 7.2 0.00029 20.5 7.2 4.4 5 1 0 5 5 5 1 DiGeorge syndrome critical region 6 (DGCR6) protein GRP PF07172.11 EFA83940.1 - 0.019 15.6 18.5 0.022 15.4 18.5 1.1 1 0 0 1 1 1 0 Glycine rich protein family adh_short PF00106.25 EFA83941.1 - 1.1e-32 113.0 0.2 2.1e-31 108.9 0.2 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA83941.1 - 4.3e-17 62.5 0.2 1.8e-15 57.1 0.2 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA83941.1 - 3.8e-08 33.4 0.0 7.2e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EFA83941.1 - 0.00092 19.5 0.1 0.012 15.9 0.1 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ISPD_C PF18706.1 EFA83941.1 - 0.0022 17.7 2.4 0.011 15.4 1.0 2.1 2 0 0 2 2 2 1 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain Epimerase PF01370.21 EFA83941.1 - 0.04 13.4 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_C32 PF05411.12 EFA83941.1 - 0.11 12.4 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 Equine arteritis virus putative proteinase Bot1p PF12298.8 EFA83942.1 - 2e-08 34.6 0.8 3.5e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein MRP-L20 PF12824.7 EFA83942.1 - 0.0054 16.9 1.4 0.019 15.1 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 Pes-10 PF07149.11 EFA83942.1 - 8.4 5.3 14.8 13 4.7 14.8 1.2 1 0 0 1 1 1 0 Pes-10 BSP_II PF05432.11 EFA83943.1 - 0.00086 19.1 13.5 0.00086 19.1 13.5 2.1 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) MCM_bind PF09739.9 EFA83943.1 - 0.0018 16.8 9.9 0.0018 16.8 9.9 1.7 2 0 0 2 2 2 1 Mini-chromosome maintenance replisome factor Pox_Ag35 PF03286.14 EFA83943.1 - 0.082 12.7 22.7 0.071 12.9 14.7 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 EFA83943.1 - 0.084 13.2 19.1 1.2 9.6 1.9 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spt5_N PF11942.8 EFA83943.1 - 0.096 13.7 20.8 0.17 12.9 8.3 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Merozoite_SPAM PF07133.11 EFA83943.1 - 0.15 12.0 34.7 0.65 10.0 4.8 2.3 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) CAC1F_C PF16885.5 EFA83943.1 - 0.18 11.4 15.8 0.15 11.7 14.6 1.4 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Paf1 PF03985.13 EFA83943.1 - 0.2 10.6 21.3 0.023 13.7 10.9 2.1 2 0 0 2 2 2 0 Paf1 DUF4746 PF15928.5 EFA83943.1 - 0.38 10.1 20.3 0.26 10.7 13.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) PRP38_assoc PF12871.7 EFA83943.1 - 0.49 11.0 15.8 0.4 11.3 7.7 2.4 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 PF14851.6 EFA83943.1 - 0.6 9.8 16.3 0.24 11.0 8.3 2.3 2 0 0 2 2 2 0 FAM176 family PIEZO PF15917.5 EFA83943.1 - 0.96 8.9 12.8 2.4 7.6 7.2 2.1 2 0 0 2 2 2 0 Piezo RR_TM4-6 PF06459.12 EFA83943.1 - 1.1 9.1 16.6 0.37 10.6 9.3 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 NOA36 PF06524.12 EFA83943.1 - 1.5 8.1 22.3 0.34 10.2 9.2 2.1 2 0 0 2 2 2 0 NOA36 protein Vfa1 PF08432.10 EFA83943.1 - 1.6 9.1 19.7 1.8 8.8 12.1 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PI3K_1B_p101 PF10486.9 EFA83943.1 - 2 6.1 10.8 0.33 8.7 4.4 2.0 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PH_BEACH PF14844.6 EFA83943.1 - 2.1 8.5 7.3 6.7 6.9 3.3 2.6 2 0 0 2 2 2 0 PH domain associated with Beige/BEACH CPSF100_C PF13299.6 EFA83943.1 - 3.8 7.7 20.3 0.045 13.9 8.2 2.4 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CENP-H PF05837.12 EFA83943.1 - 5.3 7.5 19.1 2.7 8.4 11.9 2.5 3 0 0 3 3 3 0 Centromere protein H (CENP-H) GEN1_C PF18380.1 EFA83943.1 - 5.5 7.9 18.5 16 6.5 12.0 2.5 2 1 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain FAM60A PF15396.6 EFA83943.1 - 9.2 6.2 12.8 5.5 6.9 7.3 2.1 2 0 0 2 2 2 0 Protein Family FAM60A DUF4637 PF15470.6 EFA83943.1 - 9.8 5.9 18.9 0.7 9.6 8.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) adh_short PF00106.25 EFA83944.1 - 5.6e-60 202.2 1.0 7.7e-30 103.8 0.7 3.6 2 2 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA83944.1 - 1.3e-36 126.3 0.1 7.2e-18 65.0 0.0 3.5 2 2 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA83944.1 - 1.1e-14 54.7 0.2 5.5e-07 29.7 0.1 2.3 2 0 0 2 2 2 2 KR domain Shikimate_DH PF01488.20 EFA83944.1 - 0.0015 18.6 1.1 3.1 7.9 0.2 3.3 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase ISPD_C PF18706.1 EFA83944.1 - 0.0093 15.6 1.0 0.036 13.7 0.8 2.1 2 0 0 2 2 2 1 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain Peptidase_C32 PF05411.12 EFA83944.1 - 0.038 13.9 0.0 2.6 8.0 0.0 2.9 3 0 0 3 3 3 0 Equine arteritis virus putative proteinase Baculo_LEF-11 PF06385.12 EFA83944.1 - 0.067 13.7 0.1 4.7 7.8 0.0 2.5 2 0 0 2 2 2 0 Baculovirus LEF-11 protein LMWPc PF01451.21 EFA83945.1 - 1e-31 110.3 0.0 1.3e-30 106.7 0.0 2.2 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Coiled PF05710.12 EFA83946.1 - 0.11 13.3 10.5 0.16 12.8 10.5 1.3 1 1 0 1 1 1 0 Coiled coil RabGAP-TBC PF00566.18 EFA83948.1 - 2.2e-20 73.3 4.6 2.5e-20 73.1 4.6 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain CCDC50_N PF15295.6 EFA83948.1 - 0.024 14.8 2.9 0.037 14.2 2.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus NUC PF18510.1 EFA83948.1 - 0.78 10.2 8.7 0.22 11.9 5.6 1.6 2 0 0 2 2 2 0 Nuclease domain LAGLIDADG_1 PF00961.19 EFA83948.1 - 1.2 10.2 7.9 0.62 11.1 5.8 1.6 2 0 0 2 2 2 0 LAGLIDADG endonuclease HisKA PF00512.25 EFA83949.1 - 5.5e-15 55.2 0.2 1.1e-14 54.2 0.2 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.26 EFA83949.1 - 3.1e-14 53.4 0.1 6.5e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RabGAP-TBC PF00566.18 EFA83949.1 - 1.8e-10 40.8 0.9 3.8e-10 39.8 0.9 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PAS_9 PF13426.7 EFA83949.1 - 0.012 15.8 1.4 0.024 14.9 0.1 2.2 2 0 0 2 2 2 0 PAS domain Response_reg PF00072.24 EFA83950.1 - 1.1e-20 73.9 0.1 1.3e-20 73.6 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Cob_adeno_trans PF01923.18 EFA83951.1 - 2.7e-51 173.9 0.0 3.2e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Ras PF00071.22 EFA83952.1 - 4.9e-26 91.3 0.0 1.1e-24 86.9 0.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA83952.1 - 8e-10 39.0 0.0 4.4e-07 30.1 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA83952.1 - 0.012 15.1 0.0 0.065 12.7 0.0 2.0 1 1 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA83952.1 - 0.038 13.5 0.0 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFA83952.1 - 0.12 12.5 0.1 1.3 9.1 0.1 2.1 1 1 0 2 2 2 0 50S ribosome-binding GTPase TPR_17 PF13431.6 EFA83953.1 - 9.5e-36 119.6 4.3 7.8e-08 32.2 0.0 8.5 8 1 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83953.1 - 5.1e-10 38.9 15.3 0.14 11.9 0.6 7.6 8 0 0 8 8 8 4 TPR repeat DUF1153 PF06627.11 EFA83953.1 - 0.015 15.4 0.2 87 3.3 0.0 4.9 6 0 0 6 6 6 0 Protein of unknown function (DUF1153) TPR_2 PF07719.17 EFA83953.1 - 0.051 13.7 4.2 45 4.5 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA83953.1 - 0.37 10.7 12.7 11 6.0 0.0 6.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA83953.1 - 3.9 7.9 6.6 1e+02 3.5 0.0 5.5 8 0 0 8 8 8 0 Tetratricopeptide repeat Nrap_D3 PF17404.2 EFA83954.1 - 3e-37 128.2 0.0 1e-36 126.5 0.0 2.0 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap PF03813.14 EFA83954.1 - 8.2e-34 116.8 7.9 5.8e-31 107.6 7.9 3.4 1 1 0 1 1 1 1 Nrap protein domain 1 Nrap_D5 PF17406.2 EFA83954.1 - 1.3e-32 112.8 10.4 1.7e-32 112.4 1.6 3.2 3 0 0 3 3 3 2 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 EFA83954.1 - 9e-27 93.7 6.9 2.3e-25 89.1 1.3 3.1 3 0 0 3 3 3 2 Nrap protein PAP/OAS-like domain Nrap_D4 PF17405.2 EFA83954.1 - 7.2e-25 87.6 0.9 2e-24 86.1 0.9 1.7 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D6 PF17407.2 EFA83954.1 - 1.4e-18 67.4 0.1 1.4e-18 67.4 0.1 3.4 4 1 0 4 4 4 1 Nrap protein domain 6 NESP55 PF06390.12 EFA83954.1 - 1.9 8.0 6.8 3.4 7.2 6.8 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF948 PF06103.11 EFA83955.1 - 0.023 14.9 0.8 0.051 13.8 0.8 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Csm1_N PF18504.1 EFA83955.1 - 0.066 13.6 2.0 0.16 12.4 2.0 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain TSC22 PF01166.18 EFA83955.1 - 0.61 10.4 8.0 1.1 9.6 0.6 3.4 2 1 1 3 3 3 0 TSC-22/dip/bun family SlyX PF04102.12 EFA83955.1 - 5.3 7.7 9.1 0.75 10.4 3.4 2.2 2 0 0 2 2 2 0 SlyX FAM76 PF16046.5 EFA83955.1 - 9.1 5.5 8.2 0.78 9.0 0.2 2.1 2 0 0 2 2 2 0 FAM76 protein Big_2 PF02368.18 EFA83956.1 - 1.4e-21 76.2 18.4 7.1e-06 25.8 0.0 9.5 12 0 0 12 12 12 4 Bacterial Ig-like domain (group 2) T2SS-T3SS_pil_N PF13629.6 EFA83956.1 - 0.0056 16.4 5.9 17 5.2 0.0 6.1 6 0 0 6 6 6 2 Pilus formation protein N terminal region BiPBP_C PF06832.12 EFA83956.1 - 0.021 14.9 0.0 0.99 9.5 0.0 3.0 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Glyco_hydro_49 PF03718.13 EFA83956.1 - 0.073 13.1 0.2 13 5.9 0.0 3.1 3 0 0 3 3 3 0 Glycosyl hydrolase family 49 Inhibitor_I42 PF09394.10 EFA83956.1 - 0.18 12.2 1.4 8 6.9 0.1 4.1 4 0 0 4 4 4 0 Chagasin family peptidase inhibitor I42 Glyco_transf_24 PF18404.1 EFA83957.1 - 1.2e-145 483.9 5.2 2.7e-145 482.8 5.2 1.6 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EFA83957.1 - 5.1e-43 147.9 9.7 5.4e-43 147.8 4.3 3.1 2 1 1 3 3 3 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EFA83957.1 - 8.6e-27 93.7 9.5 4.3e-25 88.2 3.4 3.7 3 0 0 3 3 3 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EFA83957.1 - 1.3e-22 80.0 0.0 3.4e-22 78.6 0.0 1.8 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_12 PF18400.1 EFA83957.1 - 4e-18 65.9 0.1 1.1e-17 64.5 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 EFA83957.1 - 5e-06 26.3 1.5 1.5e-05 24.7 1.5 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 8 Neurexophilin PF06312.12 EFA83957.1 - 0.089 12.2 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 Neurexophilin TssO PF17561.2 EFA83957.1 - 0.29 11.3 6.0 9.2 6.4 2.6 2.9 2 0 0 2 2 2 0 Type VI secretion system, TssO PTR2 PF00854.21 EFA83958.1 - 6.9e-98 328.1 10.2 6.9e-98 328.1 10.2 1.5 1 1 1 2 2 2 1 POT family DUF5080 PF16883.5 EFA83958.1 - 0.0039 17.3 1.0 0.0039 17.3 1.0 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF5080) DUF2919 PF11143.8 EFA83958.1 - 1.4 9.2 9.4 1.9 8.8 1.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2919) DUF4231 PF14015.6 EFA83958.1 - 4.2 7.9 12.1 9.7 6.7 0.3 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) TPR_1 PF00515.28 EFA83960.1 - 1.1e-19 69.4 7.1 7.6e-09 35.0 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA83960.1 - 3.6e-16 57.9 3.7 5.1e-07 29.3 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat RPAP3_C PF13877.6 EFA83960.1 - 4e-16 59.3 2.6 5.1e-16 59.0 0.7 2.2 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 TPR_8 PF13181.6 EFA83960.1 - 5.2e-11 41.8 2.9 3.3e-05 23.7 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA83960.1 - 1e-08 34.7 7.2 0.00086 18.9 0.5 3.5 3 1 1 4 4 4 3 TPR repeat TPR_12 PF13424.6 EFA83960.1 - 6.9e-06 26.3 1.6 0.05 13.9 0.2 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA83960.1 - 1.9e-05 24.3 0.2 0.0086 16.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA83960.1 - 2.4e-05 24.7 1.3 0.0043 17.6 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA83960.1 - 0.0004 21.0 0.0 0.062 14.1 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA83960.1 - 0.00043 20.9 0.1 0.22 12.2 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFA83960.1 - 0.00046 20.3 0.0 0.0095 16.1 0.0 2.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA83960.1 - 0.0014 18.9 9.9 0.54 10.8 0.0 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA83960.1 - 0.0019 18.7 1.0 1.1 9.8 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFA83960.1 - 0.0062 16.4 0.1 5.3 7.1 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 EFA83960.1 - 0.0064 16.5 6.4 1.1 9.4 0.1 3.5 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EFA83960.1 - 0.019 15.0 1.8 6.6 6.9 0.2 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EFA83960.1 - 1.5 9.1 7.4 1.5 9.1 5.3 2.2 2 1 1 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Kelch_6 PF13964.6 EFA83961.1 - 9.5e-09 35.2 6.8 0.11 12.8 0.5 4.9 4 0 0 4 4 4 3 Kelch motif zf-B_box PF00643.24 EFA83961.1 - 5.7e-07 29.6 4.9 1e-06 28.8 4.9 1.4 1 0 0 1 1 1 1 B-box zinc finger Kelch_2 PF07646.15 EFA83961.1 - 0.00014 21.7 3.1 1.2 9.3 0.1 4.6 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFA83961.1 - 0.0005 19.6 7.6 0.0039 16.7 0.2 4.0 5 0 0 5 5 5 1 Kelch motif zf-UBR PF02207.20 EFA83961.1 - 0.011 15.9 4.6 0.021 14.9 4.6 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF1668 PF07893.13 EFA83961.1 - 0.034 13.5 0.1 0.65 9.3 0.1 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1668) Rubella_E2 PF05749.11 EFA83961.1 - 0.12 11.8 2.3 0.24 10.9 2.3 1.5 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Kelch_4 PF13418.6 EFA83961.1 - 0.15 12.1 4.6 1 9.4 0.2 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain TolA_bind_tri PF16331.5 EFA83962.1 - 0.00039 20.4 50.5 0.037 14.1 13.1 6.7 3 2 3 6 6 6 3 TolA binding protein trimerisation DUF3800 PF12686.7 EFA83962.1 - 0.57 10.8 5.3 60 4.3 5.2 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) CVNH PF08881.10 EFA83962.1 - 1.4 9.6 5.6 0.76 10.5 0.6 2.4 2 0 0 2 2 2 0 CVNH domain Macoilin PF09726.9 EFA83963.1 - 2.6 6.5 35.2 3.7 6.0 35.2 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 EFA83963.1 - 3.7 7.5 25.0 4.9 7.0 25.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SNARE_assoc PF09335.11 EFA83965.1 - 4.7e-10 40.0 0.1 2.2e-08 34.6 0.2 2.6 2 0 0 2 2 2 1 SNARE associated Golgi protein Bac_export_2 PF01312.19 EFA83965.1 - 0.003 16.8 0.1 0.073 12.3 0.0 2.4 2 1 0 2 2 2 1 FlhB HrpN YscU SpaS Family Frigida PF07899.11 EFA83965.1 - 0.054 12.8 2.8 3.3 6.9 0.1 2.5 2 0 0 2 2 2 0 Frigida-like protein PRA1 PF03208.19 EFA83966.1 - 8.8e-28 96.7 4.8 1e-27 96.5 4.8 1.0 1 0 0 1 1 1 1 PRA1 family protein SdpI PF13630.6 EFA83966.1 - 9.1 6.5 9.9 2.5 8.3 2.0 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family GCP_N_terminal PF17681.1 EFA83967.1 - 1.6e-30 106.8 0.1 5.5e-30 105.0 0.0 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFA83967.1 - 0.0037 16.8 2.1 0.0074 15.8 0.8 2.2 2 1 0 2 2 2 1 Gamma tubulin complex component C-terminal Opy2 PF09463.10 EFA83968.1 - 0.44 10.9 43.4 0.3 11.4 8.2 4.9 2 2 2 4 4 4 0 Opy2 protein Methyltransf_16 PF10294.9 EFA83969.1 - 1.2e-25 90.3 1.6 2.6e-23 82.7 1.6 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFA83969.1 - 3.4e-07 30.3 0.0 4.5e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA83969.1 - 0.0017 19.0 0.1 0.019 15.7 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFA83969.1 - 0.0085 15.7 0.2 0.34 10.5 0.3 2.1 1 1 0 2 2 2 1 Nodulation protein S (NodS) Methyltransf_31 PF13847.6 EFA83969.1 - 0.0085 15.9 0.3 0.023 14.5 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA83969.1 - 0.019 15.7 0.0 1.3 9.8 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFA83969.1 - 0.021 15.4 0.0 0.49 11.1 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain DUF2706 PF10913.8 EFA83970.1 - 0.016 15.1 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) His_Phos_2 PF00328.22 EFA83971.1 - 3.1e-23 82.8 0.0 2.9e-22 79.6 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DWNN PF08783.11 EFA83972.1 - 6.4e-30 103.3 0.2 1.6e-29 102.0 0.2 1.7 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EFA83972.1 - 6.9e-09 35.4 12.3 6.9e-09 35.4 12.3 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-RING_2 PF13639.6 EFA83972.1 - 0.00011 22.5 12.9 0.00025 21.3 12.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-CCHC PF00098.23 EFA83972.1 - 0.00093 19.2 3.6 0.00093 19.2 3.6 2.6 3 0 0 3 3 3 1 Zinc knuckle zf-C3HC4 PF00097.25 EFA83972.1 - 0.24 11.3 14.8 0.56 10.1 14.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA83972.1 - 0.58 10.5 9.0 1.7 9.0 9.0 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFA83972.1 - 7.9 6.5 23.9 0.34 10.9 15.5 2.5 2 1 0 2 2 2 0 zinc-RING finger domain Guanylate_cyc_2 PF09778.9 EFA83974.1 - 1.4e-40 139.0 3.7 4e-21 75.3 0.0 3.1 2 1 0 3 3 3 3 Guanylylate cyclase Peptidase_C39_2 PF13529.6 EFA83974.1 - 3.1e-07 31.0 2.6 0.0051 17.4 0.1 3.3 1 1 1 2 2 2 2 Peptidase_C39 like family Peptidase_C39 PF03412.15 EFA83974.1 - 6.1e-06 26.1 0.1 0.0093 15.8 0.0 2.9 2 1 1 3 3 3 2 Peptidase C39 family Peptidase_C70 PF12385.8 EFA83974.1 - 0.00017 21.6 0.1 0.37 10.8 0.0 2.6 2 1 1 3 3 3 2 Papain-like cysteine protease AvrRpt2 Phytochelatin PF05023.14 EFA83974.1 - 0.024 13.8 0.1 0.055 12.7 0.0 1.6 2 0 0 2 2 2 0 Phytochelatin synthase BtrH_N PF14399.6 EFA83974.1 - 0.16 12.2 0.0 0.62 10.3 0.0 1.9 2 0 0 2 2 2 0 Butirosin biosynthesis protein H, N-terminal CAF1 PF04857.20 EFA83975.1 - 5.9e-18 65.1 0.5 1.5e-10 40.7 0.1 3.7 3 1 1 4 4 4 2 CAF1 family ribonuclease Mis12 PF05859.12 EFA83975.1 - 4.2e-17 62.5 2.4 9.4e-17 61.3 2.4 1.6 1 0 0 1 1 1 1 Mis12 protein SPX PF03105.19 EFA83975.1 - 8 6.3 27.6 6.5 6.6 8.8 2.4 2 0 0 2 2 2 0 SPX domain RRM_1 PF00076.22 EFA83976.1 - 2.3e-20 72.1 0.1 3.8e-20 71.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 EFA83976.1 - 1.1e-17 64.5 3.7 1.1e-17 64.5 3.7 2.8 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Pinin_SDK_memA PF04696.13 EFA83976.1 - 0.039 14.0 5.4 1.6 8.8 0.5 2.7 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region PHM7_cyt PF14703.6 EFA83976.1 - 0.043 14.0 0.3 0.18 12.0 0.3 2.0 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RRM_8 PF11835.8 EFA83976.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 RRM-like domain Usp PF00582.26 EFA83977.1 - 6.8e-16 59.0 0.1 2.2e-15 57.4 0.1 1.7 1 1 0 1 1 1 1 Universal stress protein family RNA_lig_T4_1 PF09511.10 EFA83977.1 - 0.048 13.5 0.1 0.055 13.3 0.1 1.2 1 0 0 1 1 1 0 RNA ligase Trp_syntA PF00290.20 EFA83977.1 - 0.091 11.6 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Tryptophan synthase alpha chain Clat_adaptor_s PF01217.20 EFA83978.1 - 8.6e-08 32.2 1.4 1.1e-07 31.9 1.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain NIF PF03031.18 EFA83980.1 - 4.6e-58 195.4 0.5 6.2e-58 195.0 0.5 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EFA83980.1 - 0.054 13.9 0.2 0.43 11.0 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase SR-25 PF10500.9 EFA83982.1 - 2.6 7.6 56.8 0.55 9.8 23.7 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Xpo1 PF08389.12 EFA83983.1 - 6.8e-18 65.2 3.4 6.8e-18 65.2 3.4 5.6 4 1 0 4 4 4 2 Exportin 1-like protein TFCD_C PF12612.8 EFA83983.1 - 0.0003 20.7 0.2 0.0012 18.7 0.2 2.1 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal DUF1722 PF08349.11 EFA83983.1 - 4.9 7.5 12.3 0.11 12.8 2.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) GST_C_3 PF14497.6 EFA83984.1 - 7.3e-21 74.2 0.0 1.1e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA83984.1 - 1.7e-07 31.3 0.0 3e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA83984.1 - 5.3e-06 26.7 0.0 1.1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF2264 PF10022.9 EFA83984.1 - 0.032 13.3 0.0 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) GST_N_3 PF13417.6 EFA83984.1 - 0.065 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA83985.1 - 1.5e-20 73.3 0.0 2e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA83985.1 - 3.2e-08 33.7 0.0 4.6e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA83985.1 - 7.1e-06 26.3 0.0 1.6e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF2264 PF10022.9 EFA83985.1 - 0.012 14.7 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) GST_C_6 PF17171.4 EFA83985.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Vac14_Fig4_bd PF11916.8 EFA83986.1 - 8.1e-70 234.1 10.4 1.2e-69 233.6 9.3 1.9 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EFA83986.1 - 4.3e-46 155.5 0.1 1.1e-41 141.3 0.0 4.8 3 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EFA83986.1 - 9.5e-10 37.9 4.2 0.013 15.7 0.0 7.1 8 0 0 8 8 8 1 HEAT repeat HEAT_EZ PF13513.6 EFA83986.1 - 4.3e-07 30.3 0.7 0.61 10.7 0.0 4.7 3 1 1 4 4 4 3 HEAT-like repeat Cnd1 PF12717.7 EFA83986.1 - 2.4e-06 27.7 7.1 0.038 14.0 0.0 4.5 2 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA83986.1 - 4.8e-05 23.7 0.0 0.28 11.6 0.0 4.2 4 0 0 4 4 4 1 HEAT repeats RTP1_C1 PF10363.9 EFA83986.1 - 0.00068 19.8 2.1 21 5.3 0.0 4.5 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.8 EFA83986.1 - 0.0067 16.4 1.3 2.8 7.8 0.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) Tam41_Mmp37 PF09139.11 EFA83986.1 - 0.024 14.1 2.0 0.15 11.5 0.0 2.7 3 0 0 3 3 3 0 Phosphatidate cytidylyltransferase, mitochondrial RasGEF_N_2 PF14663.6 EFA83986.1 - 0.053 13.9 0.6 7.9 6.9 0.0 3.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arf PF00025.21 EFA83987.1 - 3.1e-79 264.5 0.2 3.5e-79 264.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA83987.1 - 4e-15 56.1 0.0 5.8e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA83987.1 - 5.1e-15 55.4 0.0 5.9e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFA83987.1 - 2.8e-14 53.0 2.3 2e-10 40.4 0.7 2.6 2 1 1 3 3 3 2 G-protein alpha subunit Ras PF00071.22 EFA83987.1 - 1e-12 48.0 0.0 1.2e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFA83987.1 - 4.3e-12 45.9 0.0 5.3e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA83987.1 - 7.2e-06 26.1 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EFA83987.1 - 0.0071 15.7 0.6 0.023 14.0 0.3 1.8 1 1 1 2 2 2 1 6-phosphofructo-2-kinase UTP25 PF06862.12 EFA83988.1 - 6.1e-169 562.7 11.9 6.1e-169 562.7 11.9 2.1 3 0 0 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Pox_F16 PF04708.12 EFA83988.1 - 0.015 14.7 0.1 0.077 12.4 0.0 2.2 2 0 0 2 2 2 0 Poxvirus F16 protein CENP-H PF05837.12 EFA83989.1 - 0.014 15.8 3.1 0.014 15.8 3.1 4.2 5 0 0 5 5 5 0 Centromere protein H (CENP-H) Methyltransf_11 PF08241.12 EFA83990.1 - 7.1e-09 36.2 0.0 3.2e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA83990.1 - 2.3e-08 34.6 0.0 1.6e-07 31.9 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain PrmA PF06325.13 EFA83990.1 - 2.4e-08 33.7 0.6 5.4e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFA83990.1 - 6.7e-06 25.7 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.16 EFA83990.1 - 1.3e-05 25.1 0.0 2.4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.7 EFA83990.1 - 5.7e-05 23.1 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA83990.1 - 7.8e-05 23.4 1.3 0.00015 22.4 0.0 2.3 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA83990.1 - 0.00026 20.9 0.7 0.00081 19.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA83990.1 - 0.00065 19.5 0.0 0.0029 17.4 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 EFA83990.1 - 0.0014 18.1 0.1 0.0026 17.2 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 EFA83990.1 - 0.0085 15.1 0.0 0.0085 15.1 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Cons_hypoth95 PF03602.15 EFA83990.1 - 0.063 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PCMT PF01135.19 EFA83990.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Nha1_C PF08619.10 EFA83990.1 - 0.12 11.6 7.0 0.16 11.2 7.0 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Methyltransf_32 PF13679.6 EFA83990.1 - 0.12 12.3 0.1 0.12 12.3 0.1 2.4 3 0 0 3 3 3 0 Methyltransferase domain DOT1 PF08123.13 EFA83990.1 - 0.14 11.6 1.0 0.24 10.9 0.1 1.8 2 0 0 2 2 2 0 Histone methylation protein DOT1 PRP21_like_P PF12230.8 EFA83991.1 - 2.6e-48 164.8 12.7 2.6e-48 164.8 12.7 2.7 3 0 0 3 3 3 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EFA83991.1 - 3.9e-35 119.6 5.4 3.3e-17 62.2 0.7 2.5 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.23 EFA83991.1 - 5.9e-09 35.6 0.0 1.6e-08 34.2 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EFA83991.1 - 2.8e-05 24.5 1.0 7.2e-05 23.2 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain zf_UBZ PF18439.1 EFA83991.1 - 0.00043 19.8 0.9 0.0012 18.4 0.9 1.8 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger Pex14_N PF04695.13 EFA83991.1 - 0.019 15.6 29.1 0.15 12.7 7.1 3.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1644 PF07800.12 EFA83991.1 - 0.065 13.3 2.7 0.38 10.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Toprim_Crpt PF13342.6 EFA83991.1 - 0.25 11.4 2.3 5.1 7.2 0.0 3.0 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase LETM1 PF07766.13 EFA83991.1 - 4.3 6.6 9.6 0.034 13.5 1.1 1.8 2 0 0 2 2 2 0 LETM1-like protein IPU_b_solenoid PF18783.1 EFA83992.1 - 0.13 12.3 0.4 0.22 11.6 0.4 1.2 1 0 0 1 1 1 0 Isopullulanase beta-solenoid repeat PhyH PF05721.13 EFA83993.1 - 1e-05 25.9 0.0 0.0014 19.0 0.0 2.1 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Nic96 PF04097.14 EFA83994.1 - 3.7e-62 210.7 20.0 1.5e-61 208.6 9.9 3.4 2 1 1 3 3 3 2 Nup93/Nic96 DUF3600 PF12207.8 EFA83994.1 - 0.017 15.1 0.1 0.042 13.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3600) SR-25 PF10500.9 EFA83994.1 - 0.12 12.0 5.8 0.28 10.8 5.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein COX14 PF14880.6 EFA83997.1 - 2.1e-05 24.3 10.1 0.00076 19.3 10.1 2.1 1 1 0 1 1 1 1 Cytochrome oxidase c assembly LapA_dom PF06305.11 EFA83997.1 - 0.39 10.6 6.7 10 6.0 6.7 2.1 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Peptidase_M20 PF01546.28 EFA83998.1 - 1.1e-36 126.5 0.0 1.5e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA83998.1 - 1e-12 47.9 0.0 5.6e-12 45.6 0.0 2.0 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFA83998.1 - 1.9e-05 24.5 0.0 3.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 EFA83998.1 - 0.073 12.1 0.0 0.66 8.9 0.0 2.0 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase Cellulase PF00150.18 EFA83999.1 - 5.8e-30 104.7 1.9 1.3e-29 103.5 1.9 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ank_2 PF12796.7 EFA84000.1 - 1.1e-22 80.4 0.2 2e-13 50.7 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84000.1 - 1.9e-19 69.7 0.0 1.3e-05 25.6 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) HTH_9 PF08221.11 EFA84000.1 - 2.3e-17 62.8 0.1 2.3e-14 53.2 0.1 2.8 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain Ank PF00023.30 EFA84000.1 - 3.8e-15 55.6 1.9 0.0068 16.8 0.0 5.3 5 0 0 5 5 4 3 Ankyrin repeat Ank_5 PF13857.6 EFA84000.1 - 7e-14 51.7 0.1 0.0009 19.5 0.0 4.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84000.1 - 1.1e-12 46.9 1.6 0.015 15.8 0.0 5.3 6 0 0 6 6 4 3 Ankyrin repeat zinc_ribbon_2 PF13240.6 EFA84000.1 - 0.00027 20.6 3.5 0.00052 19.6 3.5 1.5 1 0 0 1 1 1 1 zinc-ribbon domain TFIIE_alpha PF02002.17 EFA84000.1 - 0.0004 20.2 3.4 0.0016 18.3 0.2 3.3 3 0 0 3 3 3 1 TFIIE alpha subunit RNA_pol_Rpc82 PF05645.13 EFA84000.1 - 0.00065 19.5 8.8 0.0091 15.8 7.5 3.1 2 1 0 2 2 2 1 RNA polymerase III subunit RPC82 DZR PF12773.7 EFA84000.1 - 0.0014 18.6 1.9 0.0036 17.3 1.9 1.6 1 0 0 1 1 1 1 Double zinc ribbon zf-NADH-PPase PF09297.11 EFA84000.1 - 0.0058 16.3 0.1 0.012 15.2 0.1 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_15 PF17032.5 EFA84000.1 - 0.018 15.8 1.4 0.094 13.5 0.7 2.4 2 0 0 2 2 2 0 zinc-ribbon family NOB1_Zn_bind PF08772.11 EFA84000.1 - 0.092 12.9 2.7 0.25 11.5 2.7 1.7 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Patatin PF01734.22 EFA84000.1 - 0.11 12.7 0.1 0.35 11.0 0.1 2.0 2 0 0 2 2 2 0 Patatin-like phospholipase Sel1 PF08238.12 EFA84001.1 - 6.2e-20 71.2 24.0 5.9e-08 33.1 0.0 8.5 9 0 0 9 9 9 6 Sel1 repeat TPR_2 PF07719.17 EFA84001.1 - 0.22 11.7 11.3 4.7 7.6 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84001.1 - 0.32 10.7 8.6 0.29 10.8 0.8 3.6 3 0 0 3 3 3 0 TPR repeat Mucin PF01456.17 EFA84001.1 - 0.51 10.3 21.1 0.93 9.5 21.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein COPI_C PF06957.11 EFA84003.1 - 2e-132 441.7 0.0 2.8e-132 441.3 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 EFA84003.1 - 2.2e-121 406.0 0.4 8.3e-121 404.1 0.1 2.0 2 1 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EFA84003.1 - 3.3e-45 151.1 11.4 3e-08 34.2 0.0 8.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA84003.1 - 7.4e-07 29.4 0.3 3.9 7.9 0.0 5.8 2 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA84003.1 - 0.014 14.1 6.4 0.25 10.0 0.1 3.6 1 1 3 4 4 4 0 Nucleoporin Nup120/160 zf-LSD1 PF06943.12 EFA84003.1 - 0.13 12.1 0.2 0.3 11.0 0.2 1.6 1 0 0 1 1 1 0 LSD1 zinc finger Pkinase_Tyr PF07714.17 EFA84004.1 - 1.3e-57 195.1 0.3 1.1e-55 188.7 0.0 2.6 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.25 EFA84004.1 - 2e-52 178.2 1.6 1.5e-51 175.3 0.0 2.7 3 1 0 3 3 3 1 Protein kinase domain TFIIA PF03153.13 EFA84004.1 - 0.00019 21.6 22.8 0.00023 21.3 22.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Haspin_kinase PF12330.8 EFA84004.1 - 0.00031 19.8 8.1 0.0027 16.7 8.1 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFA84004.1 - 0.00037 19.4 5.9 0.00053 18.9 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFA84004.1 - 0.016 14.5 0.0 0.016 14.5 0.0 1.8 2 1 0 2 2 2 0 Kinase-like APH PF01636.23 EFA84004.1 - 0.03 14.2 0.4 0.082 12.8 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFA84004.1 - 0.048 13.0 0.1 0.091 12.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Joubert PF15392.6 EFA84004.1 - 0.16 11.7 9.0 0.23 11.2 9.0 1.2 1 0 0 1 1 1 0 Joubert syndrome-associated WASH_WAHD PF11945.8 EFA84005.1 - 7e-55 186.6 1.3 9.2e-55 186.2 1.3 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex WH2 PF02205.20 EFA84005.1 - 8.2e-05 22.3 0.3 0.00019 21.2 0.3 1.6 1 0 0 1 1 1 1 WH2 motif CAF20 PF17052.5 EFA84005.1 - 0.066 13.4 1.2 0.13 12.5 1.2 1.4 1 0 0 1 1 1 0 Cap associated factor Phosducin PF02114.16 EFA84006.1 - 0.0004 19.4 0.0 0.00047 19.2 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin_8 PF13905.6 EFA84006.1 - 0.025 14.9 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin PF00085.20 EFA84006.1 - 0.039 14.0 0.2 0.05 13.6 0.2 1.2 1 0 0 1 1 1 0 Thioredoxin MerB PF03243.15 EFA84006.1 - 0.15 12.3 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Alkylmercury lyase Mito_carr PF00153.27 EFA84007.1 - 3.1e-74 245.0 5.8 2.2e-24 85.2 0.0 3.2 1 1 2 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EFA84007.1 - 1.5e-12 47.8 3.2 2.6e-12 47.0 3.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFA84007.1 - 2.5e-10 39.1 1.7 3e-05 23.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA84007.1 - 2.1e-09 36.6 1.7 2.2e-06 27.1 0.5 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFA84007.1 - 6.1e-06 26.0 2.9 0.015 15.1 0.3 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFA84007.1 - 0.0003 20.1 0.6 0.003 17.0 0.1 2.3 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 EFA84007.1 - 0.0034 17.7 0.4 0.0058 16.9 0.4 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 EFA84007.1 - 0.024 13.2 0.0 0.035 12.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) VPS13 PF16908.5 EFA84007.1 - 0.07 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal Serine_protease PF18405.1 EFA84007.1 - 0.95 8.6 4.5 2 7.5 0.1 3.3 3 1 0 4 4 4 0 Gammaproteobacterial serine protease WD40 PF00400.32 EFA84008.1 - 3.8e-23 81.3 19.3 1.3e-06 29.0 1.4 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA84008.1 - 2.7e-17 62.8 9.8 2e-07 31.2 0.5 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA84008.1 - 4.8e-07 29.1 5.2 0.0065 15.5 1.4 4.4 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFA84008.1 - 8e-05 22.6 3.5 0.0041 17.0 1.3 3.0 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EFA84008.1 - 0.0002 19.6 1.8 0.11 10.5 0.1 2.5 3 0 0 3 3 3 2 IKI3 family Ank_2 PF12796.7 EFA84009.1 - 1.2e-14 54.6 1.1 0.032 14.8 0.0 5.5 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84009.1 - 2.9e-08 33.3 2.4 29 5.7 0.0 9.0 11 1 0 11 11 11 1 Ankyrin repeat Ank_4 PF13637.6 EFA84009.1 - 6.2e-08 33.0 4.4 0.011 16.3 0.1 6.2 6 1 0 6 6 6 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84009.1 - 2.9e-06 27.5 0.8 0.58 10.6 0.0 6.4 5 2 2 7 7 7 1 Ankyrin repeats (many copies) MSV199 PF10553.9 EFA84009.1 - 0.055 13.7 4.5 0.057 13.7 0.5 2.7 2 0 0 2 2 2 0 MSV199 domain FH2 PF02181.23 EFA84011.1 - 5.4e-91 305.5 5.8 5.4e-91 305.5 5.8 2.4 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFA84011.1 - 1.5e-31 109.4 4.6 1.5e-31 109.4 4.6 2.7 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFA84011.1 - 7.5e-17 61.6 11.0 7.5e-17 61.6 11.0 2.4 2 1 0 2 2 2 1 Diaphanous FH3 Domain Auxin_canalis PF05703.11 EFA84011.1 - 0.57 10.1 9.2 0.082 12.8 4.7 1.9 2 0 0 2 2 2 0 Auxin canalisation IPU_b_solenoid PF18783.1 EFA84012.1 - 0.22 11.6 0.7 0.37 10.8 0.7 1.2 1 0 0 1 1 1 0 Isopullulanase beta-solenoid repeat Kelch_6 PF13964.6 EFA84014.1 - 1.8e-18 66.1 2.2 2e-08 34.2 0.0 4.6 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EFA84014.1 - 1.3e-05 24.7 0.2 0.0048 16.4 0.1 2.9 2 0 0 2 2 2 2 Kelch motif Snapin_Pallidin PF14712.6 EFA84014.1 - 0.0076 16.6 5.6 0.026 14.9 5.6 1.9 1 0 0 1 1 1 1 Snapin/Pallidin Kelch_4 PF13418.6 EFA84014.1 - 0.086 12.9 4.0 0.82 9.7 0.1 3.7 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA84014.1 - 0.11 12.6 7.4 0.35 10.9 0.1 3.6 3 0 0 3 3 3 0 Kelch motif zf-B_box PF00643.24 EFA84014.1 - 0.12 12.6 16.1 0.25 11.6 16.1 1.5 1 0 0 1 1 1 0 B-box zinc finger Apolipoprotein PF01442.18 EFA84014.1 - 0.12 12.3 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Rif1_N PF12231.8 EFA84015.1 - 6.2e-19 68.2 0.1 6.2e-19 68.2 0.1 2.1 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal RRP14 PF15459.6 EFA84015.1 - 0.63 10.7 9.3 3.1 8.5 9.3 2.3 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 DUF3446 PF11928.8 EFA84015.1 - 0.66 10.3 5.2 2.5 8.5 0.5 2.9 2 0 0 2 2 2 0 Early growth response N-terminal domain Rep_fac_C PF08542.11 EFA84017.1 - 1.6e-18 66.9 0.0 3.4e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFA84017.1 - 8.5e-14 51.7 0.0 4e-13 49.5 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EFA84017.1 - 4.2e-13 49.8 0.0 9.6e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFA84017.1 - 8.7e-08 32.3 0.1 6e-07 29.6 0.0 2.3 2 1 0 2 2 2 1 Rad17 P-loop domain ResIII PF04851.15 EFA84017.1 - 8.3e-06 25.9 0.1 0.023 14.7 0.0 2.7 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFA84017.1 - 7.9e-05 22.9 0.1 0.0015 18.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFA84017.1 - 0.00012 21.8 0.1 0.0014 18.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFA84017.1 - 0.00015 21.6 0.0 0.00045 20.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFA84017.1 - 0.0002 21.8 0.2 0.0017 18.7 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFA84017.1 - 0.00028 20.7 0.0 0.00049 19.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EFA84017.1 - 0.0012 18.3 0.0 0.0051 16.2 0.0 2.0 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 EFA84017.1 - 0.0019 18.5 0.0 0.0054 17.1 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_30 PF13604.6 EFA84017.1 - 0.0041 16.9 0.0 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EFA84017.1 - 0.012 15.3 0.3 0.16 11.7 0.0 2.4 2 1 1 3 3 3 0 DEAD/DEAH box helicase AAA_5 PF07728.14 EFA84017.1 - 0.019 14.9 0.2 0.18 11.8 0.2 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFA84017.1 - 0.024 13.8 0.0 0.067 12.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFA84017.1 - 0.025 14.1 0.0 0.08 12.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 EFA84017.1 - 0.026 14.0 0.0 0.39 10.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 EFA84017.1 - 0.038 14.3 0.5 0.38 11.1 0.2 2.7 1 1 1 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFA84017.1 - 0.071 13.0 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF1348 PF07080.11 EFA84018.1 - 3.1e-64 214.7 8.3 3.6e-64 214.5 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EFA84018.1 - 2.4e-05 24.9 0.4 3.3e-05 24.5 0.4 1.3 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFA84018.1 - 0.021 15.2 0.8 0.04 14.3 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) Ribosomal_60s PF00428.19 EFA84019.1 - 0.0012 19.4 0.4 0.0028 18.2 0.4 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein PAXIP1_C PF15364.6 EFA84019.1 - 0.025 14.9 3.2 0.025 14.9 3.2 2.5 2 1 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein PBP1_TM PF14812.6 EFA84019.1 - 0.038 14.4 11.5 0.52 10.7 4.0 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 EFA84019.1 - 0.39 10.4 6.4 0.57 9.8 1.2 2.2 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.14 EFA84019.1 - 5.7 6.7 7.9 2 8.1 0.5 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Astro_capsid_p PF12226.8 EFA84019.1 - 7.4 5.6 9.4 0.26 10.4 1.4 2.0 2 0 0 2 2 2 0 Turkey astrovirus capsid protein DDE_Tnp_4 PF13359.6 EFA84020.1 - 2.5e-22 79.3 0.0 3.5e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA84020.1 - 5.8e-05 22.8 0.2 0.00043 20.0 0.2 2.1 1 1 0 1 1 1 1 Transposase DDE domain OrfB_Zn_ribbon PF07282.11 EFA84021.1 - 5.6e-06 26.2 1.1 0.00063 19.6 0.1 2.5 2 0 0 2 2 2 2 Putative transposase DNA-binding domain DDHD PF02862.17 EFA84022.1 - 0.026 14.7 3.2 0.054 13.6 3.2 1.5 1 0 0 1 1 1 0 DDHD domain CxC6 PF18721.1 EFA84022.1 - 0.14 12.4 1.9 1.4 9.3 2.5 2.4 2 1 0 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases tRNA_synt_1c_R2 PF04557.15 EFA84022.1 - 0.46 11.4 21.0 1.2 10.1 21.0 1.7 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 FAM176 PF14851.6 EFA84022.1 - 1.7 8.3 10.9 3.5 7.3 10.9 1.4 1 0 0 1 1 1 0 FAM176 family ALMT PF11744.8 EFA84022.1 - 2.5 6.8 12.8 4.1 6.1 12.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Connexin PF00029.19 EFA84022.1 - 3.1 7.5 10.6 5.5 6.7 10.6 1.3 1 0 0 1 1 1 0 Connexin CobT PF06213.12 EFA84022.1 - 3.1 7.1 9.6 4.7 6.5 9.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Phage_Gp23 PF10669.9 EFA84022.1 - 3.4 8.0 19.4 8.3 6.8 16.0 2.7 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) O-antigen_lig PF13425.6 EFA84022.1 - 3.5 6.3 12.7 7.6 5.2 12.7 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2098 PF09871.9 EFA84022.1 - 5.6 7.4 11.7 18 5.8 11.7 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) DUF3915 PF13054.6 EFA84022.1 - 6.2 6.8 9.4 18 5.3 9.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) EIIBC-GUT_N PF03612.14 EFA84022.1 - 8.1 6.1 8.2 17 5.1 8.2 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Asn_synthase PF00733.21 EFA84024.1 - 5e-95 319.2 0.0 1.2e-91 308.1 0.0 2.2 1 1 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EFA84024.1 - 8.8e-41 138.7 0.0 2.8e-40 137.1 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFA84024.1 - 1.4e-30 106.2 0.0 2.7e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Ank_2 PF12796.7 EFA84024.1 - 4.5e-16 59.2 10.5 9.3e-10 39.0 1.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) DUF3700 PF12481.8 EFA84024.1 - 5.3e-15 55.5 0.1 1.3e-14 54.2 0.0 1.6 2 0 0 2 2 2 1 Aluminium induced protein Ank_5 PF13857.6 EFA84024.1 - 4.1e-13 49.3 0.2 6.9e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA84024.1 - 3e-12 46.8 3.5 4.6e-05 23.9 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA84024.1 - 3.6e-09 36.7 0.8 2.2e-05 24.7 0.2 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFA84024.1 - 6.5e-08 32.3 0.8 0.89 10.3 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeat DUF5470 PF17564.2 EFA84024.1 - 3 8.1 9.5 0.19 11.9 1.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5470) Pro_isomerase PF00160.21 EFA84025.1 - 1.6e-47 161.7 0.1 1.6e-47 161.7 0.1 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PRP1_N PF06424.12 EFA84027.1 - 7.7e-46 156.2 5.2 7.7e-46 156.2 5.2 2.0 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EFA84027.1 - 1.5e-32 109.5 10.2 0.0034 18.1 0.1 13.5 6 4 9 15 15 14 9 Tetratricopeptide repeat TPR_19 PF14559.6 EFA84027.1 - 1.1e-26 93.1 1.5 1.4e-06 28.8 0.0 8.8 8 2 0 8 8 8 5 Tetratricopeptide repeat Suf PF05843.14 EFA84027.1 - 5e-09 36.6 5.5 0.05 13.6 0.0 5.4 4 1 1 6 6 6 3 Suppressor of forked protein (Suf) TPR_2 PF07719.17 EFA84027.1 - 1.8e-07 30.7 3.5 25 5.3 0.0 8.5 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA84027.1 - 2.9e-07 30.2 6.6 1.6 9.2 0.0 8.9 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA84027.1 - 4.5e-06 26.7 11.4 8 7.1 0.0 9.5 9 2 2 11 11 10 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA84027.1 - 0.00013 22.5 1.4 4.2 8.1 0.0 5.3 5 1 1 6 6 4 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EFA84027.1 - 0.00074 18.7 0.3 0.00074 18.7 0.3 5.3 3 2 1 4 4 4 2 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 EFA84027.1 - 0.0048 17.4 8.3 24 5.9 0.0 7.5 10 0 0 10 10 6 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFA84027.1 - 0.0056 16.4 1.2 0.11 12.2 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat-like domain RuvA_C PF07499.13 EFA84027.1 - 0.042 14.3 3.4 0.59 10.6 0.9 3.1 2 0 0 2 2 2 0 RuvA, C-terminal domain TPR_9 PF13371.6 EFA84027.1 - 0.054 13.6 0.0 59 3.9 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EFA84027.1 - 0.12 12.4 0.0 0.12 12.4 0.0 3.0 4 0 0 4 4 2 0 U3 small nucleolar RNA-associated protein 6 UPF0184 PF03670.13 EFA84027.1 - 0.81 10.1 6.6 3.3 8.2 5.5 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Wzy_C_2 PF11846.8 EFA84027.1 - 2.6 8.0 5.1 1e+02 2.7 0.0 4.2 5 1 1 6 6 6 0 Virulence factor membrane-bound polymerase, C-terminal RapA_C PF12137.8 EFA84028.1 - 0.078 12.0 12.2 0.13 11.2 12.3 1.3 1 1 0 1 1 1 0 RNA polymerase recycling family C-terminal HECT PF00632.25 EFA84030.1 - 2.7e-98 329.3 1.2 7.9e-98 327.7 0.1 2.5 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 EFA84030.1 - 1.9e-49 169.0 8.3 1.9e-49 169.0 8.3 6.4 5 1 1 6 6 6 1 Domain of Unknown Function (DUF908) UBM PF14377.6 EFA84030.1 - 1.4e-26 91.1 18.5 6e-09 35.1 2.5 5.0 3 1 1 4 4 4 3 Ubiquitin binding region DUF913 PF06025.12 EFA84030.1 - 2.5e-14 53.0 7.8 2.4e-13 49.8 3.3 10.1 10 1 1 11 11 11 3 Domain of Unknown Function (DUF913) Spt20 PF12090.8 EFA84030.1 - 0.0008 19.1 8.8 0.0008 19.1 8.8 6.1 6 0 0 6 6 6 2 Spt20 family UBA PF00627.31 EFA84030.1 - 0.052 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain Peptidase_C97 PF05903.14 EFA84031.1 - 0.089 12.6 0.0 0.18 11.6 0.0 1.3 1 1 0 1 1 1 0 PPPDE putative peptidase domain Nic96 PF04097.14 EFA84032.1 - 0.34 9.3 0.5 0.42 9.0 0.5 1.0 1 0 0 1 1 1 0 Nup93/Nic96 Kelch_1 PF01344.25 EFA84034.1 - 2.8e-37 126.0 4.0 9.6e-07 28.3 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EFA84034.1 - 5.1e-35 118.9 6.1 9.6e-07 28.7 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFA84034.1 - 1.8e-30 104.7 19.4 6e-07 29.4 0.1 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA84034.1 - 6.1e-28 95.7 6.7 1.1e-05 25.2 0.2 6.9 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFA84034.1 - 3.3e-27 93.8 11.4 0.00021 21.4 0.0 6.6 5 1 1 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFA84034.1 - 7.3e-23 80.3 4.6 5.6e-08 32.9 0.1 5.9 5 0 0 5 5 5 3 Galactose oxidase, central domain F-box-like PF12937.7 EFA84034.1 - 1.7e-10 40.6 0.0 3.1e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA84034.1 - 7.2e-07 28.9 0.1 1.5e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 F-box domain EF-hand_6 PF13405.6 EFA84035.1 - 1.8e-18 64.8 15.1 0.00064 19.4 0.0 5.1 4 1 1 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 EFA84035.1 - 8.2e-17 59.4 18.2 0.001 18.5 0.1 4.8 4 1 1 5 5 5 4 EF hand EF-hand_7 PF13499.6 EFA84035.1 - 5e-15 55.7 13.1 2.6e-08 34.2 4.0 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA84035.1 - 9.1e-09 34.4 16.9 0.0015 18.0 0.5 5.0 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EFA84035.1 - 7.1e-06 26.3 5.2 0.0027 18.0 3.9 2.7 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 EFA84035.1 - 2.4e-05 24.1 12.9 0.087 12.7 2.2 4.3 3 2 1 4 4 4 3 EF-hand domain pair DapB_C PF05173.14 EFA84035.1 - 0.021 14.8 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus Polo_box_3 PF18544.1 EFA84035.1 - 0.05 14.2 1.5 0.086 13.5 1.4 1.6 1 1 0 1 1 1 0 Polo box domain Caleosin PF05042.13 EFA84035.1 - 0.2 11.6 5.5 10 6.0 0.9 3.4 1 1 3 4 4 4 0 Caleosin related protein TSP_NTD PF17804.1 EFA84035.1 - 1.4 9.1 9.0 4.1 7.6 5.5 2.1 1 1 1 2 2 2 0 Tail specific protease N-terminal domain Dockerin_1 PF00404.18 EFA84035.1 - 4.4 7.6 7.1 23 5.3 0.2 2.9 1 1 2 3 3 3 0 Dockerin type I domain MAPEG PF01124.18 EFA84036.1 - 2.3e-14 53.4 0.0 2.7e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 MAPEG family DUF2009 PF09418.10 EFA84037.1 - 1.5e-209 696.8 0.9 1.5e-209 696.8 0.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 EFA84037.1 - 2.5e-06 27.6 6.0 5e-06 26.6 6.0 1.5 1 0 0 1 1 1 1 B-box zinc finger zf-piccolo PF05715.13 EFA84037.1 - 0.046 13.9 3.1 0.12 12.5 3.1 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger Fez1 PF06818.15 EFA84037.1 - 0.11 13.0 2.9 0.53 10.7 0.1 2.4 2 0 0 2 2 2 0 Fez1 zf-C3HC4_3 PF13920.6 EFA84037.1 - 0.35 10.8 5.5 0.62 10.0 5.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3915 PF13054.6 EFA84037.1 - 8.8 6.3 10.9 0.93 9.5 5.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) ArsA_ATPase PF02374.15 EFA84038.1 - 9e-101 337.1 0.1 1.1e-100 336.8 0.1 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 EFA84038.1 - 1.2e-12 48.0 0.0 4e-12 46.3 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFA84038.1 - 1.8e-11 44.3 0.5 8.3e-11 42.1 0.0 2.3 2 2 0 2 2 2 1 AAA domain ParA PF10609.9 EFA84038.1 - 2.9e-07 30.2 1.3 0.00026 20.5 0.1 2.4 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 EFA84038.1 - 1.2e-05 24.9 0.1 2.1e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 EFA84038.1 - 7.2e-05 22.4 0.0 0.00017 21.1 0.0 1.6 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ NB-ARC PF00931.22 EFA84038.1 - 0.0011 18.3 0.0 0.002 17.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain SRP54 PF00448.22 EFA84038.1 - 0.0011 18.7 0.2 0.0036 17.0 0.1 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PhoH PF02562.16 EFA84038.1 - 0.031 13.7 0.1 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 EFA84038.1 - 0.032 13.8 0.1 0.088 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain NAF PF03822.14 EFA84038.1 - 0.039 14.1 0.1 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 NAF domain Zeta_toxin PF06414.12 EFA84038.1 - 0.13 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Methyltransf_2 PF00891.18 EFA84039.1 - 1.2e-38 132.5 0.0 1.6e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain PyrI PF01948.18 EFA84039.1 - 0.0038 17.5 0.7 0.0077 16.5 0.7 1.5 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain Dimerisation2 PF16864.5 EFA84039.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain PH PF00169.29 EFA84040.1 - 2.1e-06 28.2 0.1 5e-06 27.0 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFA84040.1 - 0.0003 21.0 0.1 0.00084 19.6 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain LysM PF01476.20 EFA84040.1 - 0.0048 16.9 0.2 0.011 15.7 0.2 1.7 1 0 0 1 1 1 1 LysM domain PH_11 PF15413.6 EFA84040.1 - 0.013 16.0 0.2 0.12 12.8 0.2 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain BTK PF00779.19 EFA84040.1 - 0.12 12.2 0.4 0.25 11.2 0.4 1.5 1 0 0 1 1 1 0 BTK motif Opiods_neuropep PF01160.18 EFA84040.1 - 0.12 12.4 0.9 0.28 11.3 0.9 1.6 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide CHORD PF04968.12 EFA84040.1 - 0.81 10.5 7.0 1.9 9.3 7.0 1.6 1 0 0 1 1 1 0 CHORD Utp13 PF08625.11 EFA84041.1 - 0.51 10.2 7.3 0.19 11.6 0.5 3.4 3 1 1 4 4 4 0 Utp13 specific WD40 associated domain TPR_8 PF13181.6 EFA84042.1 - 3.1e-15 55.1 7.6 0.0021 18.1 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFA84042.1 - 1.1e-14 53.3 4.0 0.00047 20.1 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFA84042.1 - 2.9e-14 52.3 1.8 0.00042 20.5 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA84042.1 - 4.5e-13 48.8 0.4 0.045 14.6 0.2 5.1 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA84042.1 - 3e-11 43.5 4.1 0.0018 18.6 0.0 4.3 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA84042.1 - 8.1e-11 42.3 3.8 0.00078 19.9 0.2 3.7 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA84042.1 - 1.3e-10 40.6 3.1 0.00078 19.2 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFA84042.1 - 8.2e-08 31.8 2.2 0.17 12.0 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 EFA84042.1 - 1.1e-07 32.1 0.3 5.8e-06 26.5 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA84042.1 - 4.1e-07 30.5 0.0 0.056 14.1 0.0 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA84042.1 - 1.3e-06 28.5 0.9 0.013 15.7 0.0 3.3 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFA84042.1 - 3.4e-05 23.6 0.6 0.083 12.8 0.0 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA84042.1 - 3.7e-05 24.1 2.6 1.1 10.0 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFA84042.1 - 0.00016 21.0 1.8 0.014 14.6 0.4 3.2 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84042.1 - 0.00037 20.1 3.0 0.12 12.0 0.3 4.0 4 1 1 5 5 4 1 TPR repeat TPR_3 PF07720.12 EFA84042.1 - 0.0011 18.9 1.2 3.2 7.8 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR PF01535.20 EFA84042.1 - 0.0013 18.9 0.4 1.3 9.5 0.0 4.1 4 0 0 4 4 4 1 PPR repeat Mad3_BUB1_I PF08311.12 EFA84042.1 - 0.0016 18.4 1.7 0.015 15.3 0.2 2.7 3 1 0 3 3 3 1 Mad3/BUB1 homology region 1 ChAPs PF09295.10 EFA84042.1 - 0.017 14.2 0.2 0.14 11.2 0.1 2.0 1 1 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.6 EFA84042.1 - 0.02 15.0 0.0 0.62 10.2 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat FAT PF02259.23 EFA84042.1 - 0.062 12.5 2.1 0.16 11.1 0.8 2.0 1 1 1 2 2 2 0 FAT domain PhoQ_Sensor PF08918.10 EFA84042.1 - 0.065 13.1 0.1 0.087 12.7 0.1 1.2 1 0 0 1 1 1 0 PhoQ Sensor Sel1 PF08238.12 EFA84042.1 - 0.23 12.2 5.2 29 5.5 0.0 4.1 4 0 0 4 4 4 0 Sel1 repeat DEAD PF00270.29 EFA84043.1 - 1.1e-36 126.3 0.5 3.9e-36 124.5 0.0 2.2 3 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA84043.1 - 1.8e-20 73.4 2.5 1.8e-20 73.3 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA84043.1 - 3e-10 40.4 2.1 1.4e-09 38.1 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EFA84043.1 - 0.00053 19.7 0.1 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 SWI2/SNF2 ATPase MCPsignal PF00015.21 EFA84043.1 - 0.072 12.9 0.2 0.47 10.3 0.1 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain AAA_22 PF13401.6 EFA84043.1 - 0.095 13.0 4.6 0.22 11.8 0.6 3.1 3 1 0 3 3 3 0 AAA domain Branch PF02485.21 EFA84044.1 - 8.1e-13 48.4 5.9 1.2e-12 47.9 5.9 1.3 1 0 0 1 1 1 1 Core-2/I-Branching enzyme hEGF PF12661.7 EFA84044.1 - 5.8 7.7 7.6 1.4 9.6 4.0 1.9 2 0 0 2 2 2 0 Human growth factor-like EGF Ribosomal_S8e PF01201.22 EFA84045.1 - 1e-46 158.5 8.2 1e-46 158.5 8.2 1.8 1 1 0 1 1 1 1 Ribosomal protein S8e zf-C2H2_2 PF12756.7 EFA84046.1 - 2.2e-34 117.8 16.5 2.9e-29 101.4 2.3 3.5 3 1 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFA84046.1 - 4.7e-10 39.5 4.7 8.6e-07 29.1 1.5 3.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFA84046.1 - 2e-08 34.4 8.0 2.3e-08 34.2 0.6 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EFA84046.1 - 0.00073 20.2 16.2 0.011 16.4 0.1 5.0 5 0 0 5 5 5 2 C2H2-type zinc finger DUF629 PF04780.12 EFA84046.1 - 0.036 12.6 0.1 0.036 12.6 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF629) zf-LYAR PF08790.11 EFA84046.1 - 0.04 13.8 2.4 0.37 10.7 0.3 2.9 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.6 EFA84046.1 - 0.072 13.1 0.3 0.072 13.1 0.3 2.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFA84046.1 - 0.16 12.5 0.5 0.16 12.5 0.5 4.7 5 0 0 5 5 5 0 Zinc finger, C2H2 type BolA PF01722.18 EFA84047.1 - 2e-13 50.4 0.0 2.2e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein Tmemb_170 PF10190.9 EFA84048.1 - 1.1e-29 103.0 12.6 1.2e-29 102.8 12.6 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 CRAL_TRIO PF00650.20 EFA84049.1 - 4.1e-34 117.6 0.0 8.1e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFA84049.1 - 3.1e-07 30.5 0.1 7.2e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain EMP24_GP25L PF01105.24 EFA84049.1 - 0.0019 18.2 1.0 0.0039 17.1 1.0 1.5 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CRAL_TRIO_2 PF13716.6 EFA84049.1 - 0.0024 18.0 0.0 0.005 17.0 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Mucin PF01456.17 EFA84049.1 - 0.0079 16.2 25.4 0.012 15.6 25.4 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Menin PF05053.13 EFA84049.1 - 0.59 8.4 5.4 0.8 8.0 5.4 1.1 1 0 0 1 1 1 0 Menin NST1 PF13945.6 EFA84049.1 - 1.8 8.6 10.2 3.2 7.8 10.2 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF3439 PF11921.8 EFA84049.1 - 2.3 8.2 11.5 4.4 7.3 11.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) GOLD_2 PF13897.6 EFA84049.1 - 2.5 8.6 10.0 1 9.9 0.1 3.2 2 1 1 3 3 3 0 Golgi-dynamics membrane-trafficking DUF4634 PF15465.6 EFA84049.1 - 2.9 8.2 7.6 1.7 8.9 5.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) Erf4 PF10256.9 EFA84050.1 - 1.3e-27 96.2 0.4 2.7e-27 95.2 0.4 1.5 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF1084 PF06454.11 EFA84051.1 - 4.5e-08 32.8 16.4 5.8e-08 32.5 16.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) EGF_2 PF07974.13 EFA84051.1 - 0.00027 21.2 10.9 0.00041 20.7 10.9 1.2 1 0 0 1 1 1 1 EGF-like domain Med27 PF11571.8 EFA84051.1 - 0.017 15.5 0.1 0.037 14.4 0.1 1.5 1 0 0 1 1 1 0 Mediator complex subunit 27 EB PF01683.18 EFA84051.1 - 0.18 12.1 3.2 0.32 11.3 3.2 1.3 1 0 0 1 1 1 0 EB module BSD PF03909.17 EFA84052.1 - 1.6e-12 47.2 0.7 4.2e-12 45.9 0.7 1.8 1 0 0 1 1 1 1 BSD domain BTV_NS2 PF04514.12 EFA84052.1 - 0.00051 19.0 10.5 0.00051 19.0 10.5 1.6 1 1 0 1 1 1 1 Bluetongue virus non-structural protein NS2 Endosulfine PF04667.17 EFA84053.1 - 1.1e-13 51.1 3.7 1.2e-13 51.0 3.7 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region DUF3552 PF12072.8 EFA84053.1 - 0.049 13.1 1.0 0.05 13.0 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Ank_2 PF12796.7 EFA84054.1 - 3.6e-31 107.6 4.6 1.2e-12 48.2 1.8 4.0 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84054.1 - 2.9e-30 100.9 3.7 6.2e-05 23.1 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EFA84054.1 - 3.4e-30 103.1 4.1 9e-07 29.1 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EFA84054.1 - 8.4e-27 93.2 2.4 2.4e-09 37.5 0.1 5.7 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84054.1 - 1.4e-24 85.8 10.5 6.7e-07 29.5 0.0 6.8 3 2 4 7 7 7 4 Ankyrin repeats (many copies) DUF1296 PF06972.11 EFA84054.1 - 0.0044 17.1 0.7 0.081 13.1 0.2 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1296) Methyltransf_16 PF10294.9 EFA84055.1 - 2.7e-12 46.7 0.0 3.5e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFA84055.1 - 9e-05 22.0 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFA84055.1 - 0.0013 18.3 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EFA84055.1 - 0.016 15.9 0.0 0.029 15.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EFA84055.1 - 0.059 13.0 0.0 0.098 12.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 EFA84055.1 - 0.067 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 EFA84055.1 - 0.071 12.9 0.2 0.75 9.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF938) TehB PF03848.14 EFA84055.1 - 0.092 12.2 0.1 0.19 11.1 0.1 1.5 1 1 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 EFA84055.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Apt1 PF10351.9 EFA84056.1 - 2.2 7.0 4.3 2.6 6.8 4.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 EFA84056.1 - 4.1 7.2 7.7 5.2 6.9 7.7 1.1 1 0 0 1 1 1 0 SPX domain TMEM223 PF14640.6 EFA84057.1 - 0.0081 16.3 0.2 0.0081 16.3 0.2 2.0 2 1 0 2 2 2 1 Transmembrane protein 223 Peptidase_C65 PF10275.9 EFA84057.1 - 0.026 14.0 4.1 3.8 6.9 2.8 2.2 2 0 0 2 2 2 0 Peptidase C65 Otubain Lsr2 PF11774.8 EFA84057.1 - 1.5 9.0 4.7 1.9 8.7 1.7 2.2 2 0 0 2 2 2 0 Lsr2 RasGAP_C PF03836.15 EFA84057.1 - 2.4 8.3 14.1 0.12 12.5 8.5 1.7 2 0 0 2 2 2 0 RasGAP C-terminus Mgr1 PF08602.10 EFA84057.1 - 4.3 6.1 11.1 0.99 8.2 6.0 2.0 2 0 0 2 2 2 0 Mgr1-like, i-AAA protease complex subunit Got1 PF04178.12 EFA84058.1 - 2e-31 108.7 20.2 2.6e-31 108.4 20.2 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF4064 PF13273.6 EFA84058.1 - 0.5 10.7 17.8 5.7 7.3 17.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) PMT_4TMC PF16192.5 EFA84058.1 - 1.6 8.2 13.4 36 3.9 13.4 2.0 1 1 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase SafA PF17073.5 EFA84058.1 - 2.7 8.0 6.2 1.4 8.9 4.0 1.7 1 1 1 2 2 2 0 Two-component-system connector protein DUF2070 PF09843.9 EFA84058.1 - 2.8 6.1 11.5 3.3 5.9 11.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Pox_A14 PF05767.12 EFA84058.1 - 3.1 8.0 11.0 0.097 12.8 2.2 2.3 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 RhoGEF PF00621.20 EFA84059.1 - 3e-11 43.9 1.5 6.5e-10 39.5 0.1 3.5 3 1 0 3 3 3 1 RhoGEF domain IQ_SEC7_PH PF16453.5 EFA84059.1 - 0.039 13.9 0.1 0.84 9.6 0.0 2.5 2 0 0 2 2 2 0 PH domain PH PF00169.29 EFA84059.1 - 0.094 13.2 1.2 3.3 8.3 0.6 3.2 2 1 0 2 2 2 0 PH domain PH_10 PF15411.6 EFA84059.1 - 1.5 9.1 7.0 0.5 10.6 0.1 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain KH_1 PF00013.29 EFA84060.1 - 3e-33 113.5 5.5 3.6e-16 58.7 0.6 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 EFA84060.1 - 1e-06 28.5 0.6 1e-05 25.3 0.2 2.6 2 0 0 2 2 2 1 KH domain SLS PF14611.6 EFA84060.1 - 1.7e-05 24.8 8.4 0.00096 19.0 1.1 3.1 2 1 1 3 3 3 2 Mitochondrial inner-membrane-bound regulator Ank_5 PF13857.6 EFA84060.1 - 0.00015 22.0 5.3 0.044 14.1 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeats (many copies) KH_2 PF07650.17 EFA84060.1 - 0.00039 20.2 8.6 0.066 13.0 0.5 3.1 2 1 0 2 2 2 2 KH domain Ank_4 PF13637.6 EFA84060.1 - 0.0043 17.6 0.0 0.93 10.2 0.0 2.7 1 1 2 3 3 3 1 Ankyrin repeats (many copies) FTO_NTD PF12933.7 EFA84060.1 - 0.007 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 FTO catalytic domain Ank_2 PF12796.7 EFA84060.1 - 0.01 16.4 0.0 0.25 11.9 0.0 2.5 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Nup88 PF10168.9 EFA84060.1 - 0.014 13.2 2.7 0.025 12.4 2.7 1.3 1 0 0 1 1 1 0 Nuclear pore component EMP24_GP25L PF01105.24 EFA84060.1 - 0.054 13.4 0.7 0.11 12.4 0.7 1.5 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD RNA_pol_Rpb6 PF01192.22 EFA84061.1 - 2.8e-14 52.8 0.1 4.4e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 O-antigen_lig PF13425.6 EFA84062.1 - 0.11 11.2 7.8 0.22 10.3 7.8 1.6 1 1 0 1 1 1 0 O-antigen ligase like membrane protein ISK_Channel PF02060.15 EFA84062.1 - 0.34 10.6 1.6 1.7 8.4 0.5 2.1 1 1 1 2 2 2 0 Slow voltage-gated potassium channel Acyltransferase PF01553.21 EFA84063.1 - 6.4e-21 74.4 0.0 1.2e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EFA84063.1 - 3.9e-18 65.3 0.1 9.5e-18 64.1 0.1 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus DUSP PF06337.12 EFA84063.1 - 3e-14 53.4 1.0 2.8e-13 50.3 0.1 2.5 2 0 0 2 2 2 1 DUSP domain BTB_2 PF02214.22 EFA84063.1 - 1.6e-13 50.8 0.1 1.1e-08 35.3 0.1 2.5 1 1 1 2 2 2 2 BTB/POZ domain DCP1 PF06058.13 EFA84063.1 - 0.0092 15.9 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 1 Dcp1-like decapping family Ribosomal_L13 PF00572.18 EFA84064.1 - 1e-47 161.5 0.2 1e-47 161.5 0.2 1.4 2 0 0 2 2 2 1 Ribosomal protein L13 Aldo_ket_red PF00248.21 EFA84065.1 - 7.8e-09 35.1 0.0 1.4e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Aldo/keto reductase family eIF-3_zeta PF05091.12 EFA84066.1 - 2.5e-162 541.5 9.7 3e-162 541.2 9.7 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 EFA84066.1 - 8.5e-05 22.2 0.0 0.0017 17.9 0.0 2.3 2 0 0 2 2 2 1 NMDA receptor-regulated gene protein 2 C-terminus NUFIP1 PF10453.9 EFA84067.1 - 1.7e-13 50.2 6.2 1.7e-13 50.2 6.2 6.3 7 2 0 7 7 7 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) SdrD_B PF17210.3 EFA84068.1 - 4.7e-242 786.9 58.2 3.6e-21 75.5 0.0 17.6 17 0 0 17 17 17 17 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA84068.1 - 1.2e-80 265.8 61.3 5.9e-07 29.7 0.8 19.0 20 0 0 20 20 20 16 Carboxypeptidase regulatory-like domain SpaA PF17802.1 EFA84068.1 - 2.3e-42 143.2 43.0 0.00032 20.9 0.5 16.5 15 1 1 16 16 16 12 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 EFA84068.1 - 1.6e-35 121.0 44.5 0.029 14.4 2.1 18.7 18 2 0 18 18 18 12 CarboxypepD_reg-like domain Dioxygenase_C PF00775.21 EFA84068.1 - 8.3e-08 31.9 14.3 6.3 6.2 0.0 9.1 10 0 0 10 10 10 4 Dioxygenase DUF2012 PF09430.10 EFA84068.1 - 6.9e-07 29.4 11.0 5.2 7.2 0.0 10.6 14 0 0 14 14 14 2 Protein of unknown function (DUF2012) MetallophosN PF16371.5 EFA84068.1 - 3.9e-06 27.0 31.8 0.49 10.7 0.1 11.6 14 0 0 14 14 14 3 N terminal of Calcineurin-like phosphoesterase DUF2606 PF10794.9 EFA84068.1 - 0.0015 18.3 0.0 19 5.0 0.0 6.3 8 0 0 8 8 8 1 Protein of unknown function (DUF2606) FtsX PF02687.21 EFA84069.1 - 7.4e-16 58.4 23.0 1.4e-10 41.5 8.2 6.0 6 1 0 6 6 6 2 FtsX-like permease family TMEM125 PF15109.6 EFA84069.1 - 0.065 13.6 0.1 0.35 11.2 0.1 2.3 1 0 0 1 1 1 0 TMEM125 protein family OAD_gamma PF04277.13 EFA84069.1 - 0.16 12.5 0.8 1.2 9.8 0.8 2.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FAM76 PF16046.5 EFA84070.1 - 4.8 6.5 7.9 8.6 5.6 7.9 1.4 1 0 0 1 1 1 0 FAM76 protein Med24_N PF11277.8 EFA84071.1 - 3.2e-08 32.1 24.1 6.1e-06 24.6 0.2 3.6 2 1 0 3 3 3 3 Mediator complex subunit 24 N-terminal Mucin PF01456.17 EFA84071.1 - 0.00098 19.1 22.3 0.00098 19.1 22.3 2.6 2 0 0 2 2 2 1 Mucin-like glycoprotein Pex2_Pex12 PF04757.14 EFA84071.1 - 1.1 8.9 13.1 1.7 8.2 0.3 4.0 2 1 1 3 3 3 0 Pex2 / Pex12 amino terminal region H_lectin PF09458.10 EFA84072.1 - 9.5e-23 80.2 0.1 3.1e-22 78.5 0.1 1.9 1 0 0 1 1 1 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA84072.1 - 1.8e-22 79.8 3.3 2.6e-22 79.3 3.3 1.2 1 0 0 1 1 1 1 F5/8 type C domain UQ_con PF00179.26 EFA84073.1 - 1.3e-29 102.7 0.2 2.4e-17 62.9 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme S-AdoMet_synt_C PF02773.16 EFA84075.1 - 3.5e-65 218.2 0.1 8.8e-65 216.9 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EFA84075.1 - 7.2e-48 161.8 0.0 1.5e-47 160.7 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EFA84075.1 - 5e-45 152.2 0.6 1.1e-44 151.1 0.6 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EFA84075.1 - 0.089 11.6 0.1 0.54 9.0 0.0 2.0 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Pkinase PF00069.25 EFA84076.1 - 1.9e-65 220.9 0.0 5.1e-65 219.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84076.1 - 2e-50 171.5 0.0 5e-50 170.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase GATA PF00320.27 EFA84076.1 - 1.1e-15 56.9 2.8 2.2e-15 56.0 2.8 1.5 1 0 0 1 1 1 1 GATA zinc finger Kinase-like PF14531.6 EFA84076.1 - 3.1e-05 23.4 0.0 0.083 12.2 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFA84076.1 - 0.0027 16.5 7.6 0.0027 16.5 7.6 2.2 1 1 1 2 2 2 1 Fungal protein kinase ABC1 PF03109.16 EFA84076.1 - 0.046 13.9 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 ABC1 family STPPase_N PF16891.5 EFA84076.1 - 0.12 12.8 0.4 26 5.3 0.0 2.5 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain NARP1 PF12569.8 EFA84076.1 - 0.43 9.4 13.7 0.81 8.5 13.7 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CobT PF06213.12 EFA84076.1 - 1.5 8.1 14.2 2.9 7.2 14.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDRGK PF09756.9 EFA84076.1 - 1.6 8.3 26.0 5.1 6.6 26.0 1.8 1 0 0 1 1 1 0 DDRGK domain CNDH2_C PF16858.5 EFA84076.1 - 2.6 7.9 18.1 0.23 11.3 11.9 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Peptidase_U57 PF05582.12 EFA84076.1 - 3.2 6.9 8.5 8.2 5.6 8.5 1.6 1 0 0 1 1 1 0 YabG peptidase U57 Eapp_C PF10238.9 EFA84076.1 - 4.2 7.4 10.8 0.55 10.3 5.6 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein Connexin PF00029.19 EFA84076.1 - 9.1 6.0 12.7 21 4.7 12.7 1.6 1 0 0 1 1 1 0 Connexin Peptidase_C12 PF01088.21 EFA84077.1 - 8.5e-59 198.8 0.1 8.5e-59 198.8 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 HORMA PF02301.18 EFA84078.1 - 6.5e-05 22.6 15.3 0.057 13.0 10.9 3.1 1 1 1 2 2 2 2 HORMA domain FdhE PF04216.12 EFA84078.1 - 0.081 12.8 1.0 0.11 12.3 1.0 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Presenilin PF01080.17 EFA84078.1 - 0.096 11.4 0.5 0.11 11.2 0.5 1.3 1 0 0 1 1 1 0 Presenilin NAM PF02365.15 EFA84079.1 - 0.0012 19.8 0.4 0.0012 19.8 0.4 2.1 2 0 0 2 2 2 1 No apical meristem (NAM) protein 3-HAO PF06052.12 EFA84080.1 - 6.1e-58 194.7 0.1 7.2e-58 194.5 0.1 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EFA84080.1 - 2.6e-05 23.8 0.0 3.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EFA84080.1 - 0.049 13.2 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Cupin AraC_binding PF02311.19 EFA84080.1 - 0.21 11.5 0.0 0.31 10.9 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain Pro-kuma_activ PF09286.11 EFA84081.1 - 2e-33 115.6 0.0 8e-33 113.7 0.0 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFA84081.1 - 2e-06 27.3 0.1 3.3e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Subtilase family GHMP_kinases_C PF08544.13 EFA84081.1 - 0.077 13.4 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 GHMP kinases C terminal ATP-synt_ab PF00006.25 EFA84082.1 - 2.2e-61 207.2 0.0 3.6e-61 206.5 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFA84082.1 - 2.1e-18 66.6 2.7 1.9e-16 60.4 2.7 2.7 1 1 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF885 PF05960.11 EFA84082.1 - 0.0059 16.3 1.6 0.0095 15.6 1.6 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) AAA PF00004.29 EFA84082.1 - 0.0066 16.9 0.0 0.092 13.2 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EFA84082.1 - 0.0082 15.3 1.5 0.019 14.2 0.3 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 EFA84082.1 - 0.019 15.3 0.0 0.057 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFA84082.1 - 0.022 14.7 0.4 0.069 13.1 0.2 1.9 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 EFA84082.1 - 0.042 13.8 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EFA84082.1 - 0.15 11.6 0.1 0.58 9.6 0.1 2.0 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFA84082.1 - 0.17 12.3 2.2 0.49 10.8 0.0 2.9 4 0 0 4 4 4 0 RNA helicase AAA_19 PF13245.6 EFA84082.1 - 0.18 12.1 0.7 0.46 10.8 0.2 1.9 2 0 0 2 2 2 0 AAA domain Arfaptin PF06456.13 EFA84082.1 - 0.27 10.8 5.0 0.74 9.3 2.0 2.3 2 0 0 2 2 2 0 Arfaptin-like domain ABC_tran PF00005.27 EFA84082.1 - 1.1 9.8 4.6 0.78 10.2 0.4 2.6 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 EFA84082.1 - 5 6.4 7.8 0.35 10.2 1.4 2.1 2 0 0 2 2 2 0 KaiC Oxidored_FMN PF00724.20 EFA84083.1 - 1.8e-47 162.3 0.0 2.2e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFA84083.1 - 0.074 12.1 0.1 0.47 9.5 0.0 2.0 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Mito_carr PF00153.27 EFA84084.1 - 4.7e-64 212.4 3.2 8.5e-21 73.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_S19 PF00203.21 EFA84085.1 - 5.5e-30 103.1 0.3 8.1e-30 102.5 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 HhH-GPD PF00730.25 EFA84085.1 - 0.15 12.5 0.0 0.16 12.4 0.0 1.1 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein HAD_2 PF13419.6 EFA84086.1 - 6.1e-10 39.5 0.1 8.3e-10 39.0 0.1 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFA84086.1 - 8.9e-09 35.9 0.0 2.2e-08 34.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFA84086.1 - 1.5e-07 31.4 0.0 2.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Acetyltransf_1 PF00583.25 EFA84087.1 - 5.9e-12 45.9 0.0 8.6e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA84087.1 - 2.7e-08 33.8 0.1 3.9e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA84087.1 - 2.7e-06 27.7 0.0 4.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA84087.1 - 3.6e-05 23.6 0.0 5.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein CAF1C_H4-bd PF12265.8 EFA84087.1 - 0.1 12.9 0.1 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex DUF4407 PF14362.6 EFA84088.1 - 0.077 12.3 7.0 1.3 8.3 6.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Nas2_N PF18265.1 EFA84089.1 - 2.4e-23 81.9 0.1 9.2e-23 80.0 0.0 2.1 2 0 0 2 2 2 1 Nas2 N_terminal domain Ras PF00071.22 EFA84089.1 - 2.8e-22 79.1 1.5 2.3e-15 56.6 0.3 3.1 2 1 0 2 2 2 2 Ras family Roc PF08477.13 EFA84089.1 - 1.5e-09 38.1 0.3 3.4e-06 27.3 0.1 3.8 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase PDZ_2 PF13180.6 EFA84089.1 - 0.00018 21.8 0.0 0.0014 19.0 0.0 2.4 2 1 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EFA84089.1 - 0.00048 19.9 0.0 0.0019 18.0 0.0 2.1 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EFA84089.1 - 0.003 17.9 0.0 0.011 16.0 0.0 2.0 1 0 0 1 1 1 1 PDZ domain CCDC24 PF15669.5 EFA84089.1 - 0.02 14.8 0.8 0.02 14.8 0.8 2.4 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 24 family Mucin PF01456.17 EFA84089.1 - 3.3 7.7 23.6 0.41 10.6 15.1 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein RRP14 PF15459.6 EFA84089.1 - 4.5 7.9 7.8 67 4.2 3.8 3.0 3 0 0 3 3 3 0 60S ribosome biogenesis protein Rrp14 RhoGEF PF00621.20 EFA84090.1 - 5.7e-07 29.9 14.1 0.024 14.9 1.2 4.1 3 1 1 4 4 4 3 RhoGEF domain zf_CCCH_4 PF18345.1 EFA84091.1 - 1.6e-06 28.0 19.6 0.0039 17.2 0.3 5.0 4 1 0 4 4 4 3 Zinc finger domain zf-CCCH PF00642.24 EFA84091.1 - 0.00016 21.5 24.2 0.0031 17.4 0.2 4.9 5 0 0 5 5 5 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DSPn PF14671.6 EFA84091.1 - 0.017 15.6 0.3 0.066 13.7 0.3 2.0 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half zf-CCCH_3 PF15663.5 EFA84091.1 - 0.021 15.0 2.1 0.021 15.0 2.1 3.5 3 1 1 4 4 4 0 Zinc-finger containing family zf-C3H1 PF10650.9 EFA84091.1 - 0.039 13.7 1.0 0.039 13.7 1.0 3.7 4 0 0 4 4 4 0 Putative zinc-finger domain Torus PF16131.5 EFA84091.1 - 0.13 12.9 0.3 0.13 12.9 0.3 5.4 2 1 2 5 5 5 0 Torus domain zf-CCCH_4 PF18044.1 EFA84091.1 - 9.6 6.1 25.7 0.35 10.7 0.3 4.9 4 2 0 4 4 4 0 CCCH-type zinc finger CLN3 PF02487.17 EFA84092.1 - 1.4e-49 169.2 18.9 2.4e-45 155.3 0.6 2.5 2 1 1 3 3 3 2 CLN3 protein Peptidase_M20 PF01546.28 EFA84092.1 - 2.8e-20 72.9 0.0 5.1e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA84092.1 - 1.6e-09 37.7 0.0 8.2e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 Peptidase dimerisation domain Potass_KdpF PF09604.10 EFA84092.1 - 0.46 10.5 4.5 1.5 8.9 4.5 1.9 1 0 0 1 1 1 0 F subunit of K+-transporting ATPase (Potass_KdpF) Glycos_transf_2 PF00535.26 EFA84093.1 - 5.9e-14 52.2 0.0 7.2e-07 29.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EFA84093.1 - 0.00068 19.2 0.2 0.37 10.2 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EFA84093.1 - 0.0088 16.5 0.0 0.12 12.9 0.0 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 CoA_binding PF02629.19 EFA84093.1 - 0.2 12.3 0.0 0.38 11.5 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain RhoGAP PF00620.27 EFA84094.1 - 2.2e-28 99.0 0.0 4.7e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain RPEL PF02755.15 EFA84094.1 - 0.0009 18.9 0.0 0.0009 18.9 0.0 2.1 2 0 0 2 2 2 1 RPEL repeat Nup84_Nup100 PF04121.13 EFA84095.1 - 2.2e-170 568.3 20.7 3.8e-170 567.5 20.7 1.3 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Mito_carr PF00153.27 EFA84095.1 - 0.16 11.9 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial carrier protein zf-B_box PF00643.24 EFA84096.1 - 2.3e-08 34.0 9.6 4.6e-08 33.1 9.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA84096.1 - 0.035 14.4 0.1 70 3.9 0.0 3.8 4 0 0 4 4 4 0 Kelch motif Ub-Mut7C PF14451.6 EFA84096.1 - 0.045 13.6 0.2 0.67 9.8 0.2 2.5 1 1 0 1 1 1 0 Mut7-C ubiquitin CCDC84 PF14968.6 EFA84096.1 - 1.1 8.8 8.2 1.7 8.2 8.2 1.3 1 0 0 1 1 1 0 Coiled coil protein 84 NARG2_C PF10505.9 EFA84097.1 - 2.2e-26 92.7 0.5 4.6e-26 91.7 0.5 1.4 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus zf-CCCH PF00642.24 EFA84097.1 - 0.24 11.4 0.3 0.5 10.3 0.3 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PAS_11 PF14598.6 EFA84097.1 - 0.25 11.5 5.5 0.062 13.4 1.1 2.3 3 0 0 3 3 3 0 PAS domain zf-CCCH_4 PF18044.1 EFA84097.1 - 0.27 11.1 2.5 0.56 10.1 2.5 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger GAGA_bind PF06217.12 EFA84097.1 - 0.45 10.7 22.4 0.077 13.3 1.6 3.6 3 1 1 4 4 4 0 GAGA binding protein-like family zf_CCCH_4 PF18345.1 EFA84097.1 - 2.9 8.1 4.2 7.8 6.7 4.2 1.8 1 0 0 1 1 1 0 Zinc finger domain Dynamin_N PF00350.23 EFA84098.1 - 2.2e-22 79.9 10.0 1.9e-21 76.8 0.0 3.2 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EFA84098.1 - 1.3e-06 28.4 0.1 0.035 14.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EFA84098.1 - 0.0014 19.0 1.7 0.056 13.8 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AIG1 PF04548.16 EFA84098.1 - 0.012 15.0 0.2 6.4 6.0 0.0 2.7 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 EFA84098.1 - 0.028 14.3 1.7 0.17 11.8 0.0 3.1 4 0 0 4 4 4 0 RsgA GTPase AAA_14 PF13173.6 EFA84098.1 - 0.029 14.4 0.4 1.8 8.6 0.0 3.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA84098.1 - 0.035 14.6 0.0 0.035 14.6 0.0 3.4 4 0 0 4 4 4 0 ABC transporter Ras PF00071.22 EFA84098.1 - 0.038 13.6 0.1 7.3 6.2 0.0 3.0 1 1 1 2 2 2 0 Ras family DUF4758 PF15950.5 EFA84098.1 - 0.046 14.1 0.5 0.26 11.6 0.5 2.3 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein AAA_29 PF13555.6 EFA84098.1 - 0.082 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EFA84098.1 - 0.095 12.9 0.0 0.61 10.3 0.0 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Hit1_C PF18268.1 EFA84098.1 - 0.11 12.7 0.1 4.8 7.4 0.1 2.7 2 0 0 2 2 2 0 Hit1 C-terminal COG2 PF06148.11 EFA84098.1 - 0.2 11.7 0.0 0.2 11.7 0.0 3.2 3 0 0 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA_23 PF13476.6 EFA84098.1 - 0.59 10.6 24.0 0.67 10.4 0.0 3.9 4 0 0 4 4 4 0 AAA domain HSP70 PF00012.20 EFA84098.1 - 2.6 6.1 12.5 0.13 10.4 6.4 1.9 2 0 0 2 2 2 0 Hsp70 protein APG6_N PF17675.1 EFA84098.1 - 3.2 8.3 28.4 7.2 7.2 11.1 3.6 3 1 0 3 3 3 0 Apg6 coiled-coil region U79_P34 PF03064.16 EFA84098.1 - 8 5.8 17.6 20 4.5 17.6 1.6 1 0 0 1 1 1 0 HSV U79 / HCMV P34 zf-CDGSH PF09360.10 EFA84101.1 - 6.8e-13 48.6 15.1 3.1e-06 27.3 6.1 4.0 3 1 0 3 3 3 2 Iron-binding zinc finger CDGSH type UDG PF03167.19 EFA84102.1 - 7e-22 78.1 0.0 1.2e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Caldesmon PF02029.15 EFA84102.1 - 0.058 12.1 27.9 0.074 11.8 27.9 1.1 1 0 0 1 1 1 0 Caldesmon SOBP PF15279.6 EFA84102.1 - 0.74 10.4 9.9 1.1 9.8 9.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein RhoGEF PF00621.20 EFA84103.1 - 6.5e-25 88.4 1.4 1.4e-24 87.4 0.1 2.1 2 1 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EFA84103.1 - 4.1e-18 65.3 12.1 7.6e-18 64.4 12.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EFA84103.1 - 9.3e-13 48.6 3.7 1.4e-12 48.1 0.4 2.6 3 0 0 3 3 3 1 PH domain IQ_SEC7_PH PF16453.5 EFA84103.1 - 3.2e-06 27.2 0.1 7e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 EFA84103.1 - 0.00089 19.1 1.2 0.026 14.4 0.0 2.6 2 1 1 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.6 EFA84103.1 - 0.012 15.8 0.3 0.055 13.6 0.3 2.1 1 1 0 1 1 1 0 PH domain PH_16 PF17838.1 EFA84103.1 - 0.032 14.1 0.4 0.47 10.3 0.4 2.3 1 1 0 1 1 1 0 PH domain RhoGEF PF00621.20 EFA84104.1 - 3.7e-12 46.9 1.3 6.1e-12 46.1 1.3 1.4 1 0 0 1 1 1 1 RhoGEF domain DIOX_N PF14226.6 EFA84105.1 - 3.1e-26 92.5 0.0 4.5e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFA84105.1 - 1.6e-23 83.1 0.0 2.7e-23 82.4 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Acetyltransf_1 PF00583.25 EFA84106.1 - 1.7e-17 63.8 0.0 2.1e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA84106.1 - 9.2e-10 38.8 0.0 1.4e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA84106.1 - 2.3e-08 34.0 0.0 3.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA84106.1 - 3.2e-06 27.8 0.0 4.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA84106.1 - 2.1e-05 24.4 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFA84106.1 - 0.00039 20.5 0.0 0.00071 19.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EFA84106.1 - 0.00058 19.9 0.0 0.018 15.1 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFA84106.1 - 0.0066 15.9 0.1 0.014 14.9 0.1 1.5 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_4 PF13420.7 EFA84106.1 - 0.012 15.7 0.0 0.085 13.0 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EFA84106.1 - 0.054 13.0 0.2 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 GNAT acetyltransferase Fer4_5 PF12801.7 EFA84106.1 - 0.17 11.8 2.4 0.31 11.0 2.4 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain CCER1 PF15482.6 EFA84107.1 - 0.0014 18.6 2.5 0.0017 18.3 2.5 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing glutamate-rich protein family 1 ISK_Channel PF02060.15 EFA84107.1 - 0.051 13.3 4.2 0.081 12.6 4.2 1.4 1 0 0 1 1 1 0 Slow voltage-gated potassium channel zf-B_box PF00643.24 EFA84108.1 - 1.6e-06 28.2 2.8 3.4e-06 27.1 2.8 1.6 1 0 0 1 1 1 1 B-box zinc finger DUF3573 PF12097.8 EFA84108.1 - 0.023 13.5 2.2 0.031 13.1 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF4164 PF13747.6 EFA84108.1 - 0.15 12.4 1.5 0.25 11.6 1.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) Mod_r PF07200.13 EFA84108.1 - 0.15 12.2 8.5 0.069 13.3 1.4 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TIG PF01833.24 EFA84109.1 - 3.4e-09 36.6 4.5 1.9e-07 31.1 1.7 8.9 9 1 0 10 10 10 4 IPT/TIG domain EGF_2 PF07974.13 EFA84109.1 - 4e-08 33.5 32.6 0.00042 20.6 7.3 3.0 3 0 0 3 3 3 2 EGF-like domain Lectin_C PF00059.21 EFA84109.1 - 7e-06 26.7 0.1 7e-06 26.7 0.1 3.4 2 1 0 2 2 2 1 Lectin C-type domain EB PF01683.18 EFA84109.1 - 0.011 16.0 18.9 0.18 12.1 3.9 2.7 2 0 0 2 2 2 0 EB module Plasmod_Pvs28 PF06247.11 EFA84109.1 - 7.3 7.0 11.4 27 5.2 3.1 3.4 2 0 0 2 2 2 0 Pvs28 EGF domain B_lectin PF01453.24 EFA84111.1 - 0.0049 17.4 0.7 2.7 8.6 0.6 2.3 1 1 1 2 2 2 2 D-mannose binding lectin DUF4559 PF15112.6 EFA84112.1 - 0.032 13.9 2.6 0.1 12.3 2.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) ApeC PF16977.5 EFA84112.1 - 0.087 12.8 0.8 2.6 8.0 0.2 2.2 2 0 0 2 2 2 0 C-terminal domain of apextrin Phytochelatin PF05023.14 EFA84112.1 - 0.12 11.6 1.7 0.29 10.3 1.9 1.5 2 0 0 2 2 2 0 Phytochelatin synthase Metallophos_2 PF12850.7 EFA84113.1 - 4.1e-23 82.4 0.4 5.4e-23 82.0 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFA84113.1 - 0.002 18.7 0.8 0.74 10.3 0.8 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3439 PF11921.8 EFA84115.1 - 2.3 8.2 6.4 0.34 10.9 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) NDUF_C2 PF06374.11 EFA84116.1 - 0.00028 21.0 0.0 0.00033 20.8 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) DUF2177 PF09945.9 EFA84116.1 - 0.11 12.6 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2177) ubiquitin PF00240.23 EFA84117.1 - 2.2e-56 187.5 5.4 3.5e-33 113.2 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFA84117.1 - 3.6e-26 90.8 7.3 4.3e-15 55.3 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA84117.1 - 5e-11 42.9 2.3 0.0002 21.7 0.1 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA84117.1 - 7.3e-07 29.5 1.8 0.013 15.8 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA84117.1 - 3.6e-06 26.8 0.6 0.03 14.2 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFA84117.1 - 0.00021 21.3 10.6 1.1 9.4 0.5 4.0 3 1 1 4 4 4 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA84117.1 - 0.00044 20.3 0.4 0.057 13.5 0.0 2.8 2 2 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.8 EFA84117.1 - 0.00085 19.5 0.1 0.022 15.0 0.0 2.1 2 0 0 2 2 2 1 TUG ubiquitin-like domain Big_3_3 PF13750.6 EFA84117.1 - 0.012 15.3 0.0 3.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Sde2_N_Ubi PF13019.6 EFA84117.1 - 0.014 15.2 0.0 0.39 10.5 0.0 2.0 1 1 1 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain DUF2407 PF10302.9 EFA84117.1 - 0.017 15.7 0.2 0.082 13.5 0.1 1.9 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain DUF5420 PF17457.2 EFA84117.1 - 0.036 13.9 0.6 0.28 11.1 0.3 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5420) APG12 PF04110.13 EFA84117.1 - 0.043 14.2 0.2 1.2 9.6 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 UN_NPL4 PF11543.8 EFA84117.1 - 0.045 14.2 0.9 0.36 11.3 0.2 2.2 2 1 0 2 2 2 0 Nuclear pore localisation protein NPL4 HEAT PF02985.22 EFA84118.1 - 0.00014 21.9 0.1 4 8.0 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat RTP1_C1 PF10363.9 EFA84118.1 - 0.00054 20.1 2.8 0.0033 17.6 0.1 3.3 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EFA84118.1 - 0.036 14.5 0.0 0.96 9.9 0.0 2.7 2 0 0 2 2 2 0 HEAT repeats SPX PF03105.19 EFA84118.1 - 0.51 10.2 47.0 0.0087 16.0 15.9 2.2 2 0 0 2 2 2 0 SPX domain Pkinase PF00069.25 EFA84119.1 - 9e-65 218.7 0.0 1.1e-64 218.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84119.1 - 8.3e-19 67.9 0.0 1.2e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA84119.1 - 5.5e-08 33.0 0.0 9.3e-07 29.0 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA84119.1 - 0.0029 16.4 0.2 0.012 14.4 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 EFA84119.1 - 0.03 13.9 0.4 0.06 12.9 0.4 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EFA84119.1 - 0.046 13.1 0.4 0.075 12.4 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 2OG-FeII_Oxy_2 PF13532.6 EFA84120.1 - 4.7e-46 157.5 0.1 1.2e-44 152.8 0.1 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Ras PF00071.22 EFA84120.1 - 2e-37 128.3 0.5 5.9e-37 126.8 0.5 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA84120.1 - 3.3e-22 79.0 0.3 8.6e-22 77.6 0.3 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA84120.1 - 1.1e-10 41.2 0.2 1.9e-10 40.4 0.2 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA84120.1 - 1.8e-05 24.4 1.2 4.8e-05 23.0 1.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SPC25 PF06703.11 EFA84120.1 - 0.024 14.4 0.7 0.024 14.4 0.7 1.8 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) SirB PF04247.12 EFA84120.1 - 0.026 14.6 0.9 0.056 13.5 0.9 1.5 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB Peptidase_U4 PF03419.13 EFA84120.1 - 0.076 12.3 2.5 0.16 11.2 2.5 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Sec23_trunk PF04811.15 EFA84122.1 - 7.8e-44 150.1 0.0 1.4e-43 149.2 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFA84122.1 - 3.7e-30 104.5 0.1 7.3e-30 103.6 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EFA84122.1 - 6.4e-24 83.8 0.1 1.1e-23 83.0 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EFA84122.1 - 2.4e-12 46.6 0.0 8e-12 44.9 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat GM_CSF PF01109.17 EFA84122.1 - 0.14 12.3 0.1 0.44 10.7 0.0 1.9 2 0 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor Bromodomain PF00439.25 EFA84123.1 - 2.5e-20 72.3 1.7 5.1e-20 71.3 1.7 1.5 1 0 0 1 1 1 1 Bromodomain Thioredoxin PF00085.20 EFA84124.1 - 8e-64 212.1 3.0 2.2e-31 107.9 0.2 2.8 2 0 0 2 2 2 2 Thioredoxin SNF2_N PF00176.23 EFA84124.1 - 1.5e-51 175.2 0.5 2.8e-51 174.3 0.1 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain ERp29 PF07749.12 EFA84124.1 - 7e-22 78.1 2.6 7e-22 78.1 2.6 2.4 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Helicase_C PF00271.31 EFA84124.1 - 8.5e-19 67.9 0.0 1.3e-17 64.1 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Thioredoxin_2 PF13098.6 EFA84124.1 - 2.2e-08 34.5 2.1 0.0088 16.5 0.1 3.5 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFA84124.1 - 7.2e-08 32.7 0.2 0.06 13.7 0.0 5.4 2 2 2 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EFA84124.1 - 6.6e-07 29.4 0.1 0.064 13.5 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like ResIII PF04851.15 EFA84124.1 - 6.6e-07 29.5 0.0 6.6e-07 29.5 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AhpC-TSA PF00578.21 EFA84124.1 - 3.7e-06 26.9 1.0 0.074 13.0 0.0 3.2 3 0 0 3 3 3 2 AhpC/TSA family DUF2439 PF10382.9 EFA84124.1 - 0.023 15.0 0.9 0.14 12.5 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) PA28_beta PF02252.18 EFA84125.1 - 4.5e-49 165.9 3.1 4.5e-49 165.9 3.1 1.4 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 EFA84125.1 - 0.0043 17.1 1.4 0.012 15.6 0.4 2.3 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit IF4E PF01652.18 EFA84126.1 - 5e-41 140.1 0.0 7.7e-41 139.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PHD PF00628.29 EFA84127.1 - 5.2e-22 77.5 39.7 2.6e-09 36.8 7.8 3.9 3 0 0 3 3 3 3 PHD-finger Myb_DNA-binding PF00249.31 EFA84127.1 - 4.2e-05 23.6 0.0 0.00027 21.1 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Mucin PF01456.17 EFA84127.1 - 0.00095 19.2 18.9 0.00095 19.2 18.9 4.5 4 0 0 4 4 4 2 Mucin-like glycoprotein Zf_RING PF16744.5 EFA84127.1 - 0.00097 19.2 16.9 0.19 11.9 1.8 4.2 3 1 0 3 3 3 2 KIAA1045 RING finger PHD_2 PF13831.6 EFA84127.1 - 0.0022 17.5 23.8 0.0061 16.1 0.7 3.8 3 0 0 3 3 3 2 PHD-finger EVE PF01878.18 EFA84127.1 - 0.0049 16.9 0.5 0.03 14.3 0.5 2.2 1 1 0 1 1 1 1 EVE domain Prok-RING_1 PF14446.6 EFA84127.1 - 0.0059 16.5 23.3 0.061 13.3 4.7 3.9 3 0 0 3 3 3 2 Prokaryotic RING finger family 1 Myb_DNA-bind_6 PF13921.6 EFA84127.1 - 0.0067 16.7 0.4 0.049 13.9 0.3 2.6 3 0 0 3 3 3 1 Myb-like DNA-binding domain zf-PHD-like PF15446.6 EFA84127.1 - 0.012 15.2 26.0 0.09 12.4 0.1 4.2 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 EFA84127.1 - 0.1 12.5 22.0 0.13 12.2 0.9 4.1 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TCP PF03634.13 EFA84127.1 - 1.2 9.7 0.0 1.2 9.7 0.0 8.1 7 3 1 8 8 6 0 TCP family transcription factor LPAM_1 PF08139.12 EFA84128.1 - 1.3 9.7 4.5 2.9 8.5 4.5 1.7 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site LIAS_N PF16881.5 EFA84129.1 - 3.6e-23 82.0 0.3 7.8e-23 81.0 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EFA84129.1 - 1.7e-12 48.1 0.0 2.9e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily BPL_LplA_LipB PF03099.19 EFA84130.1 - 1.9e-06 27.8 0.0 8.5e-06 25.7 0.0 2.0 2 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family FNIP PF05725.12 EFA84132.1 - 3.1e-61 203.3 41.0 1.5e-12 47.5 0.6 12.8 3 3 11 14 14 14 12 FNIP Repeat F-box-like PF12937.7 EFA84132.1 - 3.8e-06 26.7 0.1 1.1e-05 25.2 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA84132.1 - 0.00057 19.7 0.0 0.0027 17.5 0.0 2.3 1 0 0 1 1 1 1 F-box domain Rcd1 PF04078.13 EFA84133.1 - 1.8e-118 394.5 1.9 2.2e-118 394.3 1.9 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DUF3012 PF11216.8 EFA84135.1 - 0.088 12.9 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) FNIP PF05725.12 EFA84136.1 - 0.0011 19.1 1.2 0.0011 19.1 1.2 2.1 2 0 0 2 2 2 1 FNIP Repeat F-box PF00646.33 EFA84136.1 - 0.0017 18.2 2.0 0.0017 18.2 2.0 2.3 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EFA84136.1 - 0.0027 17.6 0.9 0.0027 17.6 0.9 2.6 3 0 0 3 3 3 1 F-box-like F-box_5 PF18511.1 EFA84136.1 - 0.084 12.5 0.1 0.22 11.1 0.1 1.8 1 0 0 1 1 1 0 F-box 7tm_2 PF00002.24 EFA84137.1 - 1.6e-26 93.1 15.9 2.1e-26 92.7 15.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EFA84137.1 - 4e-21 75.4 17.2 4.8e-21 75.2 17.2 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 EFA84137.1 - 2.4e-09 36.7 23.3 2.9e-06 26.6 8.7 2.5 1 1 1 3 3 3 2 Frizzled/Smoothened family membrane region Ocular_alb PF02101.15 EFA84137.1 - 1.4e-06 27.5 7.4 1.4e-06 27.5 7.4 2.1 2 1 0 3 3 3 1 Ocular albinism type 1 protein DUF1616 PF07760.11 EFA84137.1 - 0.52 9.7 3.3 1.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) MIR PF02815.19 EFA84138.1 - 0.28 11.0 5.1 0.49 10.2 5.1 1.3 1 0 0 1 1 1 0 MIR domain SR-25 PF10500.9 EFA84138.1 - 1.2 8.7 23.2 0.06 13.0 11.8 2.5 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein DUF3246 PF11596.8 EFA84138.1 - 1.4 8.3 6.4 3.6 7.0 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) FAM176 PF14851.6 EFA84138.1 - 4.8 6.8 6.7 2.8 7.6 3.3 2.2 2 0 0 2 2 2 0 FAM176 family DUF4611 PF15387.6 EFA84138.1 - 7.7 6.8 11.8 0.41 10.9 4.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) DUF3245 PF11595.8 EFA84138.1 - 8.5 6.8 10.6 1.1 9.8 4.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) MCM PF00493.23 EFA84139.1 - 3.6e-76 255.2 0.2 7.1e-76 254.2 0.2 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFA84139.1 - 1.4e-21 76.6 0.8 3.8e-21 75.2 0.8 1.7 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFA84139.1 - 1.7e-17 63.6 0.6 3.7e-17 62.5 0.6 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFA84139.1 - 2.9e-09 36.6 0.4 5.9e-06 25.8 0.1 2.7 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA84139.1 - 7.7e-08 32.4 0.3 2.2e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFA84139.1 - 0.00016 21.4 0.3 0.0011 18.7 0.3 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 EFA84139.1 - 0.00062 20.2 0.7 0.0027 18.1 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EFA84139.1 - 0.0015 18.3 1.4 0.0032 17.2 1.4 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EFA84139.1 - 0.0031 17.4 0.0 0.0069 16.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA84139.1 - 0.058 13.8 2.6 0.097 13.1 0.1 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_19 PF13245.6 EFA84139.1 - 0.18 12.2 3.1 0.89 9.9 0.1 2.9 2 1 0 2 2 2 0 AAA domain zf_UBZ PF18439.1 EFA84139.1 - 0.31 10.7 2.9 0.32 10.6 0.5 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Glyco_hydro_35 PF01301.19 EFA84140.1 - 2.1e-100 336.4 3.7 2.8e-100 336.0 3.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EFA84140.1 - 2.6e-09 36.9 6.8 8.5e-09 35.2 0.8 3.1 2 1 0 2 2 2 1 Beta-galactosidase GHD PF17834.1 EFA84140.1 - 3e-05 24.0 0.8 7.2e-05 22.8 0.8 1.6 1 0 0 1 1 1 1 Beta-sandwich domain in beta galactosidase MRP-S27 PF10037.9 EFA84140.1 - 0.0081 15.1 0.2 0.012 14.5 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 Ank_4 PF13637.6 EFA84141.1 - 1.3e-34 118.1 2.3 9.9e-05 22.8 0.0 9.6 7 1 0 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84141.1 - 1.1e-33 115.7 1.4 2.7e-07 31.1 0.0 6.8 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84141.1 - 5.3e-26 87.8 2.7 0.0061 17.0 0.0 12.7 10 2 3 13 13 13 5 Ankyrin repeat Ank_5 PF13857.6 EFA84141.1 - 5.7e-19 67.9 8.1 0.035 14.4 0.0 11.5 3 2 8 12 12 12 5 Ankyrin repeats (many copies) LSM PF01423.22 EFA84141.1 - 3.4e-12 45.9 2.2 3.6e-12 45.8 0.5 1.9 2 0 0 2 2 2 1 LSM domain DUF3447 PF11929.8 EFA84141.1 - 1.6e-08 34.4 8.7 0.87 9.6 0.1 6.5 4 2 2 6 6 6 4 Domain of unknown function (DUF3447) Ank PF00023.30 EFA84141.1 - 7.5e-06 26.2 0.0 4.7 7.8 0.0 6.5 5 2 1 6 6 6 1 Ankyrin repeat Ipi1_N PF12333.8 EFA84141.1 - 0.12 13.0 0.3 0.85 10.2 0.0 2.5 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation SNAPc19 PF15497.6 EFA84142.1 - 0.00023 21.5 2.8 0.00023 21.5 2.8 1.8 2 0 0 2 2 2 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Glyco_hydro_9 PF00759.19 EFA84143.1 - 4.3e-131 438.1 8.2 4.9e-131 437.9 8.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Lysine_decarbox PF03641.14 EFA84144.1 - 4.3e-40 136.9 0.0 5.5e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFA84144.1 - 1.1e-12 47.8 0.1 1.4e-12 47.5 0.1 1.1 1 0 0 1 1 1 1 SLOG cluster4 family Scramblase PF03803.15 EFA84145.1 - 1.8e-38 132.1 0.0 2.7e-38 131.5 0.0 1.3 1 1 0 1 1 1 1 Scramblase HSP20 PF00011.21 EFA84146.1 - 1.1e-21 76.9 0.1 1.7e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFA84146.1 - 5.7e-07 29.0 0.0 9.1e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA VCBS PF13517.6 EFA84147.1 - 5.2e-06 27.0 0.2 0.2 12.3 0.0 4.3 4 0 0 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFA84147.1 - 0.025 14.7 12.0 0.046 13.9 0.2 3.4 3 0 0 3 3 3 0 FG-GAP repeat Ribosomal_L13 PF00572.18 EFA84148.1 - 1.7e-11 44.5 0.0 1.6e-09 38.1 0.0 2.6 1 1 0 1 1 1 1 Ribosomal protein L13 tRNA_anti-codon PF01336.25 EFA84149.1 - 0.039 14.0 0.0 0.08 12.9 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain TusA PF01206.17 EFA84149.1 - 0.083 12.7 0.1 9.5 6.1 0.0 2.6 2 0 0 2 2 2 0 Sulfurtransferase TusA p450 PF00067.22 EFA84150.1 - 1.2e-92 311.1 0.0 1.8e-92 310.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 PhoLip_ATPase_C PF16212.5 EFA84150.1 - 1.5e-75 254.2 31.0 1.5e-75 254.2 31.0 3.6 3 1 1 4 4 4 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA84150.1 - 2e-17 62.6 5.8 1e-16 60.3 5.8 2.3 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Ricin_B_lectin PF00652.22 EFA84150.1 - 5e-10 39.7 9.1 1.1e-09 38.6 9.1 1.6 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DUF3472 PF11958.8 EFA84150.1 - 5.9e-09 36.6 3.3 1.7e-08 35.1 3.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3472) E1-E2_ATPase PF00122.20 EFA84150.1 - 1.5e-07 31.1 0.0 1.5e-07 31.1 0.0 3.0 4 1 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFA84150.1 - 4e-07 30.0 0.0 1.4e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA84150.1 - 4.6e-07 30.3 0.0 0.064 13.5 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA84150.1 - 0.052 13.3 0.1 0.052 13.3 0.1 2.6 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF5376 PF17346.2 EFA84150.1 - 0.54 10.6 5.5 2.5 8.4 3.5 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5376) Wx5_PLAF3D7 PF09688.10 EFA84151.1 - 0.49 10.4 3.3 1.1 9.3 3.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) UPF0220 PF05255.11 EFA84152.1 - 1.7e-32 112.3 2.4 1.9e-32 112.1 2.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) FA_desaturase PF00487.24 EFA84152.1 - 0.0094 15.8 1.9 0.92 9.3 0.1 2.1 1 1 0 2 2 2 2 Fatty acid desaturase DctQ PF04290.12 EFA84152.1 - 0.018 15.0 1.5 0.072 13.0 0.1 2.1 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Cation_ATPase_C PF00689.21 EFA84152.1 - 0.28 10.9 4.6 0.4 10.4 4.5 1.3 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF4731 PF15875.5 EFA84153.1 - 0.0012 19.0 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4731) EGF_2 PF07974.13 EFA84153.1 - 0.011 16.1 9.8 0.024 15.0 9.8 1.6 1 0 0 1 1 1 0 EGF-like domain Complex1_LYR_2 PF13233.6 EFA84154.1 - 9.3e-13 48.7 1.9 1.3e-12 48.3 1.9 1.4 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EFA84154.1 - 3.6e-06 26.9 0.7 6.6e-06 26.1 0.7 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) SNARE_assoc PF09335.11 EFA84155.1 - 1.5e-29 102.9 3.2 1.5e-29 102.9 3.2 2.7 3 0 0 3 3 3 1 SNARE associated Golgi protein GPI2 PF06432.11 EFA84155.1 - 0.24 10.8 7.1 0.49 9.8 0.1 2.9 2 1 1 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase DUF2613 PF11021.8 EFA84155.1 - 0.29 11.3 0.1 0.29 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) PhoLip_ATPase_C PF16212.5 EFA84155.1 - 0.59 9.8 14.9 0.056 13.2 4.3 2.3 2 1 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal NVEALA PF14055.6 EFA84155.1 - 0.97 9.5 3.1 0.82 9.7 0.7 2.1 2 0 0 2 2 2 0 NVEALA protein DUF2207 PF09972.9 EFA84155.1 - 1.2 7.9 12.8 1.5 7.5 4.4 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF2970 PF11174.8 EFA84155.1 - 4.8 7.1 10.4 1.1 9.2 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2970) Baculo_11_kDa PF06143.11 EFA84155.1 - 7.6 6.2 9.9 40 3.9 1.5 3.4 3 0 0 3 3 3 0 Baculovirus 11 kDa family Mob1_phocein PF03637.17 EFA84156.1 - 5.8e-79 264.0 0.2 6.8e-79 263.8 0.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family cNMP_binding PF00027.29 EFA84157.1 - 3.2e-15 55.9 1.0 9.9e-08 32.0 0.0 3.7 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Lactamase_B_2 PF12706.7 EFA84157.1 - 1.8e-09 37.4 0.0 4.8e-09 36.0 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFA84157.1 - 0.00021 21.3 0.7 0.00057 19.9 0.7 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily FSA_C PF10479.9 EFA84157.1 - 0.057 11.6 8.2 0.085 11.0 8.2 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Sporozoite_P67 PF05642.11 EFA84157.1 - 0.16 10.1 3.5 0.23 9.5 3.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Acetyltransf_1 PF00583.25 EFA84158.1 - 5.2e-18 65.4 0.1 6.8e-18 65.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EFA84158.1 - 1.7e-08 35.2 0.0 2.2e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA84158.1 - 1.3e-07 31.9 0.0 2.2e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA84158.1 - 4.9e-06 26.5 0.0 7.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA84158.1 - 1.1e-05 25.3 0.0 3.2e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_4 PF13420.7 EFA84158.1 - 0.0031 17.7 0.0 0.0069 16.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFA84158.1 - 0.045 13.8 0.0 0.096 12.8 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFA84158.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.3 1 1 0 1 1 1 0 Putative acetyl-transferase PH PF00169.29 EFA84159.1 - 1.5e-06 28.7 0.1 1.5e-06 28.7 0.1 2.6 2 1 1 3 3 3 1 PH domain PH_11 PF15413.6 EFA84159.1 - 0.016 15.6 0.0 0.016 15.6 0.0 3.6 4 0 0 4 4 4 0 Pleckstrin homology domain Macoilin PF09726.9 EFA84159.1 - 4.9 5.6 44.7 2.9 6.3 15.3 2.3 1 1 1 2 2 2 0 Macoilin family 2-oxoacid_dh PF00198.23 EFA84160.1 - 3e-71 239.6 0.0 4.5e-71 239.0 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 EFA84160.1 - 4.3e-10 39.8 0.0 1.1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain CM_1 PF07736.11 EFA84160.1 - 0.031 14.7 0.5 0.064 13.7 0.5 1.4 1 0 0 1 1 1 0 Chorismate mutase type I Tir_receptor_C PF07489.11 EFA84160.1 - 0.62 10.0 13.2 0.9 9.5 12.3 1.6 1 1 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus TPR_17 PF13431.6 EFA84161.1 - 0.0003 21.0 0.0 0.00053 20.2 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA84162.1 - 9e-60 194.9 27.7 3.6e-09 36.4 0.2 10.3 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84162.1 - 3.7e-14 52.1 28.4 0.23 11.2 0.2 8.8 9 0 0 9 9 9 6 TPR repeat Anth_Ig PF05587.13 EFA84162.1 - 0.00012 22.3 2.3 19 5.6 0.0 5.6 6 0 0 6 6 6 0 Anthrax receptor extracellular domain Lum_binding PF00677.17 EFA84162.1 - 0.00054 19.9 0.4 2.5 8.2 0.0 4.6 1 1 3 4 4 4 1 Lumazine binding domain TPR_2 PF07719.17 EFA84162.1 - 0.0046 17.0 10.7 65 4.0 0.0 8.7 10 0 0 10 10 10 0 Tetratricopeptide repeat Lyx_isomer PF07385.12 EFA84162.1 - 0.013 14.8 0.1 17 4.6 0.0 4.1 2 1 2 4 4 4 0 D-lyxose isomerase EF-hand_7 PF13499.6 EFA84162.1 - 0.029 14.8 0.0 0.17 12.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair TPR_14 PF13428.6 EFA84162.1 - 0.12 13.3 0.0 1.8e+02 3.4 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Lectin_C PF00059.21 EFA84162.1 - 0.33 11.7 4.4 7.5 7.3 0.2 4.0 2 2 3 5 5 5 0 Lectin C-type domain TPR_1 PF00515.28 EFA84162.1 - 0.87 9.5 21.2 38 4.3 0.1 9.4 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA84163.1 - 1.4e-13 50.2 4.9 0.00023 21.3 0.9 4.6 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84163.1 - 0.0073 16.0 2.7 0.98 9.2 0.3 3.3 3 0 0 3 3 3 2 TPR repeat DUF1153 PF06627.11 EFA84163.1 - 0.17 12.1 0.0 24 5.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1153) Mito_carr PF00153.27 EFA84164.1 - 1.7e-70 233.0 0.8 6.7e-28 96.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CBS PF00571.28 EFA84165.1 - 6e-20 71.4 6.0 7.8e-06 26.2 0.8 4.3 4 0 0 4 4 4 4 CBS domain adh_short_C2 PF13561.6 EFA84166.1 - 1.6e-44 152.2 0.0 2.7e-39 135.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFA84166.1 - 1.4e-41 142.2 0.0 6.2e-31 107.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EFA84166.1 - 3.9e-09 36.7 0.4 5e-08 33.1 0.4 2.0 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EFA84166.1 - 0.0046 16.3 0.1 0.028 13.8 0.0 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 EFA84166.1 - 0.0091 15.5 0.1 0.048 13.1 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_28 PF03033.20 EFA84166.1 - 0.083 12.9 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain AdoHcyase_NAD PF00670.21 EFA84166.1 - 0.1 12.7 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain CBS PF00571.28 EFA84167.1 - 8.5e-11 42.1 2.3 3e-06 27.6 0.3 3.7 4 0 0 4 4 4 2 CBS domain DHHA1 PF02272.19 EFA84167.1 - 2.5e-05 24.7 0.0 8.4e-05 23.0 0.0 2.0 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 EFA84167.1 - 6.6e-05 23.1 0.2 6.6e-05 23.1 0.2 2.4 2 0 0 2 2 2 1 DHH family PolyA_pol PF01743.20 EFA84167.1 - 0.0052 17.2 0.0 0.03 14.7 0.0 2.4 1 0 0 1 1 1 1 Poly A polymerase head domain Ank_2 PF12796.7 EFA84168.1 - 4.2e-22 78.5 12.7 8.7e-05 23.0 0.2 6.1 1 1 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84168.1 - 8.4e-21 74.1 12.8 0.0013 19.2 0.5 9.0 3 2 5 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84168.1 - 8.7e-16 57.8 14.9 0.028 14.7 0.1 9.8 6 3 5 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84168.1 - 7.6e-12 44.3 16.4 2.1 9.2 0.0 11.5 12 1 1 13 13 13 2 Ankyrin repeat DUF249 PF03158.13 EFA84168.1 - 0.017 14.8 14.0 0.052 13.3 1.3 4.9 2 1 3 6 6 6 0 Multigene family 530 protein Ank PF00023.30 EFA84168.1 - 3.2 8.3 6.2 6.4e+02 1.1 0.0 6.2 9 1 0 9 9 9 0 Ankyrin repeat Ank_2 PF12796.7 EFA84169.1 - 8.4e-35 119.2 14.9 7.3e-05 23.3 0.4 10.3 3 2 7 13 13 13 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84169.1 - 1.4e-30 105.3 21.0 0.0042 17.6 0.6 13.3 9 4 4 13 13 13 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84169.1 - 2.6e-22 78.6 21.5 0.0007 19.9 0.0 14.4 6 4 10 16 16 16 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84169.1 - 1.9e-19 67.7 21.6 2.4 9.0 0.0 19.2 21 0 0 21 21 21 3 Ankyrin repeat DUF5049 PF16468.5 EFA84169.1 - 0.0025 17.7 0.4 69 3.4 0.0 6.7 8 0 0 8 8 8 0 Domain of unknown function (DUF5049) TSLP PF15216.6 EFA84169.1 - 0.01 16.1 2.0 2.8 8.2 0.2 3.8 2 1 1 3 3 3 0 Thymic stromal lymphopoietin Ank PF00023.30 EFA84169.1 - 0.6 10.6 8.6 1.9e+02 2.8 0.1 6.8 6 2 0 6 6 6 0 Ankyrin repeat SAM_3 PF18016.1 EFA84169.1 - 4.6 7.1 5.3 13 5.7 0.0 3.9 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) TPR_17 PF13431.6 EFA84170.1 - 1.7e-50 165.8 19.2 1.4e-08 34.6 0.1 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84170.1 - 6.2e-16 57.8 32.1 0.029 14.0 0.1 8.7 9 0 0 9 9 9 6 TPR repeat DUF1153 PF06627.11 EFA84170.1 - 0.00018 21.5 0.7 65 3.8 0.0 6.4 8 0 0 8 8 8 0 Protein of unknown function (DUF1153) TPR_1 PF00515.28 EFA84170.1 - 0.033 14.0 19.4 23 5.0 0.0 9.4 11 0 0 11 11 11 0 Tetratricopeptide repeat P22_CoatProtein PF11651.8 EFA84170.1 - 0.042 12.5 0.1 19 3.7 0.0 3.2 1 1 3 4 4 4 0 P22 coat protein - gene protein 5 TPR_2 PF07719.17 EFA84170.1 - 0.1 12.8 7.9 41 4.6 0.1 6.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA84170.1 - 0.56 10.6 7.5 1.6e+02 2.9 0.1 6.7 7 1 1 9 9 9 0 Tetratricopeptide repeat Uma2 PF05685.12 EFA84171.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative restriction endonuclease DUF2034 PF10356.9 EFA84172.1 - 0.1 12.0 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) TPR_17 PF13431.6 EFA84174.1 - 2.9e-65 212.0 22.0 2.6e-09 36.8 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84174.1 - 7.3e-19 67.2 19.5 0.091 12.5 0.2 8.0 8 0 0 8 8 8 7 TPR repeat Anth_Ig PF05587.13 EFA84174.1 - 3.7e-06 27.2 5.6 16 5.8 0.0 6.9 8 0 0 8 8 8 2 Anthrax receptor extracellular domain Lum_binding PF00677.17 EFA84174.1 - 0.0091 16.0 0.7 6.7 6.8 0.1 4.0 1 1 1 2 2 2 1 Lumazine binding domain TPR_14 PF13428.6 EFA84174.1 - 0.013 16.2 0.0 7.8 7.6 0.0 3.9 6 0 0 6 6 6 0 Tetratricopeptide repeat EF-hand_7 PF13499.6 EFA84174.1 - 0.034 14.6 0.0 0.31 11.5 0.0 2.5 2 1 1 3 3 3 0 EF-hand domain pair Glyco_hydro_20 PF00728.22 EFA84174.1 - 0.053 12.9 0.2 0.089 12.2 0.2 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain TPR_2 PF07719.17 EFA84174.1 - 0.62 10.3 16.0 1.5e+02 2.9 0.0 9.0 10 0 0 10 10 10 0 Tetratricopeptide repeat Epiglycanin_TR PF05647.11 EFA84174.1 - 1 9.4 7.3 33 4.5 0.1 3.7 4 0 0 4 4 4 0 Tandem-repeating region of mucin, epiglycanin-like PWI PF01480.17 EFA84175.1 - 0.003 17.9 0.7 0.0072 16.6 0.7 1.7 1 0 0 1 1 1 1 PWI domain MHC2-interact PF09307.10 EFA84175.1 - 0.63 10.1 6.7 0.17 11.9 2.4 2.3 2 0 0 2 2 2 0 CLIP, MHC2 interacting SlyX PF04102.12 EFA84175.1 - 2.5 8.8 10.1 4.2 8.0 3.5 3.0 2 0 0 2 2 2 0 SlyX SapB_1 PF05184.15 EFA84175.1 - 6 7.0 6.5 1.1 9.3 0.3 2.9 3 0 0 3 3 3 0 Saposin-like type B, region 1 FERM_f0 PF16511.5 EFA84176.1 - 2.2e-26 91.9 6.3 1.9e-18 66.5 0.1 4.4 4 0 0 4 4 4 3 N-terminal or F0 domain of Talin-head FERM RhoGAP PF00620.27 EFA84176.1 - 7.1e-21 74.6 0.2 2.1e-20 73.1 0.2 1.8 1 0 0 1 1 1 1 RhoGAP domain Kindlin_2_N PF18124.1 EFA84176.1 - 3.3e-05 24.0 0.0 0.084 13.1 0.0 3.4 3 0 0 3 3 3 2 Kindlin-2 N-terminal domain TMPIT PF07851.13 EFA84177.1 - 0.0016 17.7 1.7 0.0019 17.5 1.7 1.1 1 0 0 1 1 1 1 TMPIT-like protein Syntaxin-6_N PF09177.11 EFA84177.1 - 0.047 14.2 0.1 0.093 13.3 0.1 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF4201 PF13870.6 EFA84177.1 - 0.085 12.6 0.0 0.085 12.6 0.0 2.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4201) TcdB_N PF12918.7 EFA84177.1 - 0.28 11.5 2.3 13 6.1 0.1 2.9 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain FAM176 PF14851.6 EFA84178.1 - 0.012 15.3 0.5 0.024 14.3 0.5 1.5 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 EFA84178.1 - 0.18 9.9 1.5 0.28 9.2 0.2 1.8 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Cwf_Cwc_15 PF04889.12 EFA84178.1 - 0.53 10.0 10.5 0.94 9.2 10.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein T3SS_needle_F PF09392.10 EFA84178.1 - 2.7 8.3 6.7 2.7 8.2 0.7 3.9 4 0 0 4 4 4 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF PBP1_TM PF14812.6 EFA84178.1 - 10 6.6 9.3 21 5.6 9.3 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ubiquitin PF00240.23 EFA84179.1 - 1.3e-52 175.4 4.2 1.6e-31 107.8 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFA84179.1 - 1.9e-20 72.4 5.5 5.1e-13 48.6 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA84179.1 - 1.2e-08 35.3 1.5 0.0083 16.6 0.1 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA84179.1 - 1.1e-07 32.2 1.3 0.0019 18.5 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA84179.1 - 0.00036 20.4 0.3 0.092 12.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA84179.1 - 0.0006 19.9 0.3 0.16 12.1 0.0 2.7 2 2 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFA84179.1 - 0.024 15.2 0.1 0.29 11.7 0.1 2.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFA84179.1 - 0.029 14.4 9.1 2.8 8.1 0.2 3.9 3 1 1 4 4 4 0 Ubiquitin-like domain DUF969 PF06149.12 EFA84179.1 - 0.034 13.6 0.0 0.8 9.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF969) HATPase_c PF02518.26 EFA84179.1 - 0.067 13.7 0.2 0.12 12.9 0.2 1.5 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WW_1 PF18507.1 EFA84179.1 - 0.21 11.3 0.4 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 WW domain Ank_2 PF12796.7 EFA84181.1 - 2.5e-05 24.8 0.2 0.14 12.8 0.1 3.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) RsbU_N PF08673.10 EFA84181.1 - 0.044 13.9 2.0 0.47 10.6 0.1 2.9 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain Ank_3 PF13606.6 EFA84181.1 - 0.097 13.3 0.0 40 5.2 0.0 4.1 3 0 0 3 3 3 0 Ankyrin repeat Lipase_3 PF01764.25 EFA84182.1 - 1.6e-11 44.3 0.0 6.3e-11 42.3 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) Roc PF08477.13 EFA84182.1 - 0.07 13.4 1.1 4.7 7.5 0.0 3.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFA84182.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.7 4 0 0 4 4 4 0 RsgA GTPase MMR_HSR1 PF01926.23 EFA84182.1 - 0.31 11.2 2.1 0.34 11.0 0.1 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase Acetyltransf_9 PF13527.7 EFA84183.1 - 0.00018 21.6 0.0 0.00073 19.6 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA84183.1 - 0.0002 21.6 0.0 0.0004 20.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family RPGR1_C PF18111.1 EFA84183.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.5 2 0 0 2 2 2 0 Retinitis pigmentosa G-protein regulator interacting C-terminal Dicty_CTDC PF00526.18 EFA84184.1 - 3.7e-41 138.6 176.2 3.4e-08 33.2 14.0 13.3 13 1 0 13 13 13 11 Dictyostelium (slime mold) repeat Pyr_redox_2 PF07992.14 EFA84185.1 - 1.2e-47 162.6 0.1 1.7e-47 162.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 EFA84185.1 - 6.2e-20 71.9 0.4 3.2e-13 50.2 0.0 4.1 3 2 1 4 4 4 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 EFA84185.1 - 7.1e-11 42.5 0.0 3.3e-09 37.2 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFA84185.1 - 8.1e-08 32.4 0.1 0.0033 17.4 0.0 3.9 3 1 1 4 4 4 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFA84185.1 - 3.5e-07 29.8 0.4 4.6e-05 22.8 0.1 2.5 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFA84185.1 - 4.1e-05 23.1 0.1 8.1e-05 22.1 0.1 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase K_oxygenase PF13434.6 EFA84185.1 - 0.00021 20.6 0.0 0.081 12.1 0.0 3.1 1 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 EFA84185.1 - 0.00078 19.9 0.0 0.045 14.2 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding DAO PF01266.24 EFA84185.1 - 0.0012 18.5 2.3 0.0043 16.7 0.0 2.8 4 0 0 4 4 4 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFA84185.1 - 0.0031 16.3 0.0 0.093 11.4 0.0 2.7 3 0 0 3 3 3 1 HI0933-like protein Trp_halogenase PF04820.14 EFA84185.1 - 0.03 13.2 0.1 12 4.6 0.0 3.1 3 0 0 3 3 3 0 Tryptophan halogenase Reductase_C PF14759.6 EFA84185.1 - 0.15 12.6 0.0 0.5 10.9 0.0 1.9 2 0 0 2 2 1 0 Reductase C-terminal Methyltransf_31 PF13847.6 EFA84186.1 - 3.2e-19 69.2 0.0 4.7e-19 68.7 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA84186.1 - 9.7e-19 67.8 0.0 3.5e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84186.1 - 2e-18 66.9 0.0 4.5e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84186.1 - 5.7e-16 59.1 0.0 2.3e-14 54.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA84186.1 - 6e-14 52.2 0.0 9.9e-14 51.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA84186.1 - 2.7e-09 36.7 0.0 4.3e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFA84186.1 - 0.00024 20.7 0.0 0.00057 19.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 EFA84186.1 - 0.0012 18.5 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 EFA84186.1 - 0.0016 18.2 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EFA84186.1 - 0.0043 16.4 0.0 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_29 PF03141.16 EFA84186.1 - 0.062 11.8 0.0 0.091 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 EFA84186.1 - 0.17 11.8 0.0 0.38 10.7 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Phosphodiest PF01663.22 EFA84187.1 - 9.1e-08 32.1 0.0 1.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Renin_r PF07850.14 EFA84187.1 - 0.018 15.7 0.1 0.059 14.0 0.1 1.9 1 0 0 1 1 1 0 Renin receptor-like protein RAB3GAP2_N PF14655.6 EFA84188.1 - 6.5e-134 447.3 0.2 6.5e-134 447.3 0.2 1.7 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Spt20 PF12090.8 EFA84188.1 - 0.00096 18.8 22.0 0.0099 15.5 3.9 2.5 2 0 0 2 2 2 2 Spt20 family UL42 PF17638.2 EFA84188.1 - 0.001 19.1 0.2 0.0026 17.7 0.2 1.6 1 0 0 1 1 1 1 HCMV UL42 RskA PF10099.9 EFA84188.1 - 0.062 13.6 0.2 0.062 13.6 0.2 2.6 3 0 0 3 3 3 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 EFA84188.1 - 0.11 13.5 13.1 3.5 8.7 0.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 EFA84188.1 - 0.12 11.1 12.7 0.44 9.2 1.5 2.1 2 0 0 2 2 2 0 Presenilin SLC12 PF03522.15 EFA84188.1 - 0.22 10.5 7.6 0.31 10.0 0.6 2.3 2 0 0 2 2 2 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 EFA84188.1 - 0.51 10.4 13.8 0.061 13.4 0.5 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Sporozoite_P67 PF05642.11 EFA84188.1 - 0.88 7.6 18.2 0.98 7.4 10.7 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen CPSF100_C PF13299.6 EFA84188.1 - 1.3 9.2 12.3 15 5.7 0.1 3.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Ras PF00071.22 EFA84191.1 - 2.7e-40 137.6 0.0 3.3e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA84191.1 - 5.3e-20 71.8 0.1 1.3e-19 70.5 0.0 1.7 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA84191.1 - 1.3e-06 28.0 0.0 1.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA84191.1 - 0.07 12.7 0.0 0.09 12.3 0.0 1.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Hydrolase_4 PF12146.8 EFA84193.1 - 1e-07 31.5 0.0 1.1e-06 28.2 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA84193.1 - 1.8e-07 31.1 0.0 3.6e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Spem1 PF15670.5 EFA84193.1 - 0.069 12.7 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Spermatid maturation protein 1 LIP PF03583.14 EFA84193.1 - 0.1 11.9 0.2 0.23 10.8 0.0 1.6 2 0 0 2 2 2 0 Secretory lipase Peptidase_S15 PF02129.18 EFA84193.1 - 0.25 10.9 0.1 0.63 9.6 0.1 1.5 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Ole-e-6 PF09253.10 EFA84194.1 - 0.0021 18.0 0.3 0.0023 17.9 0.3 1.1 1 0 0 1 1 1 1 Pollen allergen ole e 6 DUF4580 PF15162.6 EFA84195.1 - 0.046 13.3 0.5 0.16 11.5 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4580) Suppressor_APC PF11414.8 EFA84195.1 - 0.76 9.9 5.9 1.8 8.7 0.4 2.8 3 0 0 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein ABC2_membrane PF01061.24 EFA84196.1 - 4.1e-77 258.3 50.3 1e-43 149.2 21.5 3.5 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EFA84196.1 - 3.7e-42 144.1 0.0 2e-21 76.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFA84196.1 - 1.1e-09 38.6 0.9 0.12 12.1 0.0 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA84196.1 - 1.3e-05 25.2 0.1 0.0015 18.4 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EFA84196.1 - 1.5e-05 25.6 0.0 0.015 15.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA84196.1 - 2.3e-05 24.9 0.0 0.067 13.6 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EFA84196.1 - 0.0005 19.8 1.2 0.012 15.4 0.1 2.7 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EFA84196.1 - 0.0022 18.2 0.4 0.62 10.3 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFA84196.1 - 0.0033 17.6 0.0 0.3 11.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFA84196.1 - 0.0035 16.9 0.1 0.033 13.8 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFA84196.1 - 0.0042 17.4 0.0 0.46 10.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFA84196.1 - 0.0063 16.6 0.5 1 9.5 0.3 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_19 PF13245.6 EFA84196.1 - 0.014 15.8 0.3 0.56 10.5 0.0 3.1 2 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EFA84196.1 - 0.027 14.7 0.1 7.3 6.9 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 EFA84196.1 - 0.034 13.4 0.0 1.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 EFA84196.1 - 0.038 14.4 0.0 0.36 11.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.6 EFA84196.1 - 0.13 12.7 0.0 11 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 EFA84196.1 - 0.28 11.0 1.3 5 6.9 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.6 EFA84196.1 - 3.6 8.0 5.7 5.2 7.5 0.2 2.8 2 1 1 3 3 3 0 AAA domain Arm PF00514.23 EFA84197.1 - 9.2e-52 171.6 25.8 1.9e-07 30.9 0.0 14.1 14 0 0 14 14 14 10 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFA84197.1 - 3.4e-13 49.8 1.8 2.5e-05 24.6 0.5 6.6 7 1 1 8 8 8 2 HEAT-like repeat HEAT PF02985.22 EFA84197.1 - 2.2e-11 43.0 4.5 0.47 10.9 0.0 8.7 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 EFA84197.1 - 2.7e-11 43.7 0.1 0.00035 20.9 0.0 5.3 4 1 2 6 6 6 4 HEAT repeats Atx10homo_assoc PF09759.9 EFA84197.1 - 0.0036 17.3 14.9 0.069 13.2 0.1 6.4 6 2 2 8 8 8 3 Spinocerebellar ataxia type 10 protein domain DUF1981 PF09324.10 EFA84197.1 - 0.0091 15.8 1.5 0.24 11.3 0.1 3.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) V-ATPase_H_C PF11698.8 EFA84197.1 - 0.025 14.7 8.6 4.3 7.5 0.0 5.6 6 2 1 7 7 7 0 V-ATPase subunit H ubiquitin PF00240.23 EFA84198.1 - 4.7e-08 32.7 0.1 1.7e-07 30.9 0.1 2.1 1 0 0 1 1 1 1 Ubiquitin family VWA_2 PF13519.6 EFA84198.1 - 8.5e-07 29.6 0.0 3.4e-06 27.7 0.0 2.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Ras PF00071.22 EFA84198.1 - 0.00031 20.4 0.1 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 Ras family SSP160 PF06933.11 EFA84198.1 - 0.1 10.8 0.4 0.15 10.2 0.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Pkinase PF00069.25 EFA84199.1 - 1.7e-44 152.2 1.0 1.1e-43 149.5 1.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84199.1 - 8.5e-28 97.3 0.0 1.7e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2680 PF10925.8 EFA84199.1 - 2 8.5 10.6 0.12 12.4 2.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2680) Pkinase PF00069.25 EFA84200.1 - 1.9e-53 181.5 0.1 9.4e-53 179.3 0.1 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84200.1 - 2.1e-27 96.0 0.0 4.6e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA84200.1 - 0.0089 16.0 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family EF-hand_4 PF12763.7 EFA84200.1 - 0.027 14.4 0.1 0.11 12.4 0.1 2.1 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand MAD PF05557.13 EFA84200.1 - 0.13 10.6 44.5 0.015 13.7 39.9 1.7 2 0 0 2 2 2 0 Mitotic checkpoint protein PKcGMP_CC PF16808.5 EFA84200.1 - 0.98 9.3 27.7 0.46 10.4 0.9 5.0 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ADH_N PF08240.12 EFA84201.1 - 3.3e-23 81.6 3.5 8.1e-23 80.4 3.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFA84201.1 - 4.8e-21 75.1 0.2 8.9e-21 74.2 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA84201.1 - 0.0001 23.3 0.0 0.0002 22.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFA84201.1 - 0.00022 20.8 0.0 0.00064 19.3 0.0 1.7 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EFA84201.1 - 0.0016 17.8 0.6 0.0027 17.0 0.6 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EFA84201.1 - 0.003 17.2 0.1 0.0047 16.5 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IF-2B PF01008.17 EFA84203.1 - 1.1e-69 234.8 0.0 1.2e-69 234.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family CBM49 PF09478.10 EFA84204.1 - 3.9e-16 59.1 0.2 5.3e-16 58.7 0.2 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 SR-25 PF10500.9 EFA84205.1 - 0.81 9.2 7.2 0.84 9.2 7.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein dCMP_cyt_deam_1 PF00383.23 EFA84206.1 - 2.2e-17 62.8 0.4 2.6e-17 62.5 0.4 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EFA84206.1 - 4.4e-10 39.9 0.1 5.9e-08 33.0 0.0 2.0 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region DNA_pol_A_exo1 PF01612.20 EFA84207.1 - 3.4e-16 59.4 0.2 2.9e-09 36.9 0.0 2.8 2 1 1 3 3 3 2 3'-5' exonuclease Complex1_LYR PF05347.15 EFA84208.1 - 1.6e-08 34.5 0.4 3.3e-08 33.4 0.4 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 EFA84208.1 - 0.031 14.9 0.1 0.054 14.1 0.1 1.4 1 0 0 1 1 1 0 Complex1_LYR-like Glyco_hydro_20 PF00728.22 EFA84209.1 - 2.3e-85 287.1 4.0 8.7e-85 285.2 4.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain TPR_17 PF13431.6 EFA84209.1 - 2.9e-47 155.7 20.0 2.6e-08 33.7 0.1 8.8 8 0 0 8 8 8 8 Tetratricopeptide repeat Glycohydro_20b2 PF14845.6 EFA84209.1 - 2.1e-18 67.3 0.5 4.8e-17 62.9 0.1 3.1 2 1 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFA84209.1 - 2e-07 31.8 0.0 5.3e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 TPR_11 PF13414.6 EFA84209.1 - 2.3e-07 30.4 31.2 0.074 12.8 0.6 7.6 8 0 0 8 8 8 4 TPR repeat EF-hand_7 PF13499.6 EFA84209.1 - 0.068 13.6 0.0 0.42 11.1 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Anth_Ig PF05587.13 EFA84209.1 - 0.3 11.4 3.0 75 3.7 0.0 4.6 4 0 0 4 4 4 0 Anthrax receptor extracellular domain Epiglycanin_TR PF05647.11 EFA84209.1 - 0.76 9.7 3.3 65 3.6 0.4 3.6 3 0 0 3 3 3 0 Tandem-repeating region of mucin, epiglycanin-like TPR_17 PF13431.6 EFA84211.1 - 7.7e-69 223.3 8.2 1.3e-10 40.9 0.0 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84211.1 - 2.2e-12 46.5 19.6 0.00039 20.1 0.3 6.9 8 0 0 8 8 8 5 TPR repeat RAP80_UIM PF18282.1 EFA84211.1 - 1.7e-10 40.5 0.5 0.16 11.8 0.0 6.1 3 2 3 6 6 6 3 RAP80 N-terminal ubiquitin interaction motif Anth_Ig PF05587.13 EFA84211.1 - 0.0047 17.2 5.3 21 5.5 0.0 6.4 7 0 0 7 7 7 0 Anthrax receptor extracellular domain Lyx_isomer PF07385.12 EFA84211.1 - 0.0068 15.7 0.5 26 4.0 0.0 5.0 4 2 1 5 5 5 0 D-lyxose isomerase DUF3048_C PF17479.2 EFA84211.1 - 0.011 16.2 0.2 17 5.9 0.0 4.7 3 2 2 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain DUF4988 PF16378.5 EFA84211.1 - 0.015 15.0 10.7 7.7 6.1 0.1 5.7 3 3 2 6 6 6 0 Domain of unknown function TPR_8 PF13181.6 EFA84211.1 - 0.05 13.8 3.9 38 4.9 0.0 6.4 8 0 0 8 8 8 0 Tetratricopeptide repeat Nucleoplasmin PF03066.15 EFA84211.1 - 0.053 14.0 3.0 11 6.5 0.0 4.8 3 2 2 5 5 5 0 Nucleoplasmin/nucleophosmin domain Cadherin_5 PF17892.1 EFA84211.1 - 0.36 10.8 2.7 2.4 8.2 0.1 3.4 4 0 0 4 4 4 0 Cadherin-like domain Adeno_shaft PF00608.17 EFA84211.1 - 0.67 9.8 0.1 0.67 9.8 0.1 3.9 5 0 0 5 5 5 0 Adenoviral fibre protein (repeat/shaft region) FA_hydroxylase PF04116.13 EFA84212.1 - 2.2e-22 79.8 21.6 3.6e-22 79.1 21.6 1.3 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Beach PF02138.18 EFA84213.1 - 4.4e-116 387.1 3.4 7.2e-116 386.4 3.4 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EFA84213.1 - 1.5e-23 82.7 0.4 1.1e-22 80.0 0.1 2.8 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 EFA84213.1 - 2.4e-21 76.2 1.6 3.5e-20 72.4 1.6 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 EFA84213.1 - 1.5e-12 47.9 0.0 5e-12 46.2 0.0 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 EFA84213.1 - 7.8e-06 26.5 3.5 0.17 12.8 0.0 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat GRAM PF02893.20 EFA84213.1 - 0.0024 17.7 0.1 0.0078 16.1 0.1 1.9 1 0 0 1 1 1 1 GRAM domain RasGAP PF00616.19 EFA84214.1 - 7.1e-13 48.7 3.2 9.7e-11 41.8 0.4 2.9 3 1 0 3 3 3 2 GTPase-activator protein for Ras-like GTPase ADH_zinc_N PF00107.26 EFA84215.1 - 8.2e-26 90.5 0.5 1.5e-25 89.7 0.5 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA84215.1 - 9e-13 49.4 0.0 2.5e-12 48.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA84215.1 - 1.1e-10 41.3 0.0 4.3e-10 39.4 0.0 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFA84215.1 - 0.0031 16.8 0.2 0.0049 16.2 0.2 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EFA84215.1 - 0.0055 16.2 0.2 0.0099 15.4 0.2 1.5 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N_2 PF16884.5 EFA84215.1 - 0.038 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase PALP PF00291.25 EFA84215.1 - 0.052 13.0 0.2 0.083 12.3 0.2 1.4 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme PGM_PMM_I PF02878.16 EFA84215.1 - 0.057 13.1 0.2 0.85 9.3 0.0 2.2 1 1 1 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I HlyD PF00529.20 EFA84215.1 - 0.08 12.8 0.0 0.27 11.1 0.0 1.9 2 1 0 2 2 2 0 HlyD membrane-fusion protein of T1SS NTP_transf_7 PF07984.12 EFA84216.1 - 8.9e-24 84.3 18.1 4.3e-23 82.0 5.7 2.3 2 0 0 2 2 2 2 Nucleotidyltransferase DUF3139 PF11337.8 EFA84217.1 - 1.4 9.6 6.5 2.1 9.0 6.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) FERM_f0 PF16511.5 EFA84218.1 - 0.082 13.2 0.1 0.1 12.9 0.1 1.1 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM ABC_membrane PF00664.23 EFA84219.1 - 1.1e-12 48.2 15.1 3e-08 33.7 2.0 2.3 1 1 1 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA84219.1 - 8.2e-12 45.8 0.5 2.8e-11 44.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ECM11 PF15463.6 EFA84219.1 - 0.11 13.1 2.3 0.23 12.1 2.3 1.6 1 0 0 1 1 1 0 Extracellular mutant protein 11 Peptidase_C37 PF05416.12 EFA84219.1 - 4.3 5.7 5.2 6 5.3 5.2 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase WBS_methylT PF12589.8 EFA84220.1 - 6e-18 65.4 7.5 9.8e-18 64.7 7.5 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EFA84220.1 - 2.8e-10 40.7 0.0 5e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84220.1 - 1.3e-09 38.6 0.0 3.1e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA84220.1 - 0.00012 22.0 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84220.1 - 0.00021 22.0 0.0 0.00057 20.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 EFA84220.1 - 0.0018 18.0 0.1 0.68 9.6 0.0 2.1 2 0 0 2 2 2 2 DNA methylase Methyltransf_31 PF13847.6 EFA84220.1 - 0.0049 16.7 0.0 0.0075 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFA84220.1 - 0.0061 15.9 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EFA84220.1 - 0.03 13.7 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AdoMet_MTase PF07757.13 EFA84220.1 - 0.063 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Ras PF00071.22 EFA84221.1 - 4.3e-44 150.0 0.3 4.3e-23 81.7 0.2 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFA84221.1 - 2.4e-14 53.6 1.7 5e-06 26.7 0.0 3.4 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 EFA84221.1 - 8.7e-13 48.7 1.3 3e-12 47.0 1.3 2.0 1 0 0 1 1 1 1 PH domain Arf PF00025.21 EFA84221.1 - 4.6e-06 26.2 0.2 0.032 13.7 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family PH_6 PF15406.6 EFA84221.1 - 1.3e-05 25.4 0.0 3.7e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Coatomer_E PF04733.14 EFA84222.1 - 3.1e-92 309.1 4.1 3.5e-92 308.9 4.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EFA84222.1 - 1.6e-05 25.3 3.2 0.0094 16.4 0.0 3.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA84222.1 - 0.0094 16.2 0.2 3.4 8.0 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA84222.1 - 7.7 6.9 9.0 7.9 6.9 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat CCDC53 PF10152.9 EFA84223.1 - 1.1e-42 146.1 0.3 1.1e-42 146.1 0.3 3.6 2 2 0 2 2 2 1 Subunit CCDC53 of WASH complex CPSF100_C PF13299.6 EFA84223.1 - 2.1 8.5 5.1 0.32 11.2 0.9 1.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ubiquitin PF00240.23 EFA84224.1 - 3.7e-21 74.7 0.4 5.9e-21 74.0 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA84224.1 - 7.1e-09 35.4 0.3 1.3e-08 34.5 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EFA84224.1 - 1.7e-08 34.2 0.8 1.7e-08 34.2 0.8 2.8 2 0 0 2 2 2 1 UBA/TS-N domain Ubiquitin_5 PF18037.1 EFA84224.1 - 0.00012 22.4 0.1 0.00021 21.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Pik1 PF11522.8 EFA84224.1 - 0.0037 17.2 0.1 0.016 15.2 0.1 2.1 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 CUE PF02845.16 EFA84224.1 - 0.0051 16.5 0.1 0.017 14.8 0.1 2.0 1 0 0 1 1 1 1 CUE domain Ubiquitin_2 PF14560.6 EFA84224.1 - 0.0075 16.7 0.3 0.019 15.4 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain STI1 PF17830.1 EFA84224.1 - 0.0076 16.2 45.3 0.22 11.5 7.8 5.6 2 2 3 5 5 5 3 STI1 domain TBK1_ULD PF18396.1 EFA84224.1 - 0.0091 15.9 1.4 0.051 13.5 0.1 2.3 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFA84224.1 - 0.011 16.3 0.0 0.026 15.1 0.0 1.7 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain HOIP-UBA PF16678.5 EFA84224.1 - 0.015 15.3 0.0 0.038 14.0 0.0 1.7 1 0 0 1 1 1 0 HOIP UBA domain pair HECW1_helix PF18436.1 EFA84224.1 - 0.032 14.4 3.7 1.3 9.2 0.2 3.0 2 1 1 3 3 3 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 BSD PF03909.17 EFA84224.1 - 0.044 13.8 4.2 0.64 10.1 0.1 3.7 2 2 2 4 4 4 0 BSD domain Keratin_2_head PF16208.5 EFA84224.1 - 0.066 13.4 40.0 0.53 10.4 15.0 2.2 2 0 0 2 2 2 0 Keratin type II head RsmJ PF04378.13 EFA84224.1 - 0.097 11.9 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ RPN13_C PF16550.5 EFA84224.1 - 0.098 12.8 5.5 0.93 9.7 0.6 2.9 2 1 0 2 2 2 0 UCH-binding domain Elf4 PF07011.11 EFA84224.1 - 0.32 10.9 2.6 0.86 9.5 0.7 2.5 2 0 0 2 2 2 0 Early Flowering 4 domain DUF1180 PF06679.12 EFA84224.1 - 1.9 8.9 8.6 0.24 11.8 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) YlbD_coat PF14071.6 EFA84224.1 - 2.5 8.4 4.9 1.2 9.4 1.1 2.4 2 1 0 2 2 2 0 Putative coat protein Com_YlbF PF06133.11 EFA84224.1 - 2.9 8.5 10.8 1.7 9.3 0.3 3.7 3 2 1 4 4 3 0 Control of competence regulator ComK, YlbF/YmcA Peptidase_C39_2 PF13529.6 EFA84225.1 - 1.6e-13 51.4 0.2 3.9e-13 50.2 0.2 1.7 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFA84225.1 - 1.7e-12 47.5 0.0 2.9e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Peptidase_C39 PF03412.15 EFA84225.1 - 5.6e-09 35.9 0.0 1.6e-06 28.0 0.0 2.3 1 1 0 1 1 1 1 Peptidase C39 family Guanylate_cyc_2 PF09778.9 EFA84225.1 - 0.0021 17.5 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 2 Guanylylate cyclase DUF3335 PF11814.8 EFA84225.1 - 0.0056 16.2 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase_C39 like family Sugar_tr PF00083.24 EFA84226.1 - 1.3e-80 271.5 39.4 1.9e-79 267.7 39.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFA84226.1 - 4e-30 104.9 43.3 3.1e-29 102.0 35.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Rick_17kDa_Anti PF05433.15 EFA84226.1 - 0.23 11.4 6.2 0.69 9.8 6.2 1.9 1 0 0 1 1 1 0 Glycine zipper 2TM domain TMEM247 PF15444.6 EFA84226.1 - 2.5 8.1 4.2 2.8 7.9 2.9 1.6 1 1 0 1 1 1 0 Transmembrane protein 247 MFS_3 PF05977.13 EFA84226.1 - 4.3 5.6 21.5 0.46 8.8 10.9 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector PheRS_DBD1 PF18552.1 EFA84227.1 - 0.077 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 PheRS DNA binding domain 1 SpoVAC_SpoVAEB PF03862.13 EFA84228.1 - 4.1 7.7 12.6 2.6 8.4 4.7 3.1 2 1 0 2 2 2 0 SpoVAC/SpoVAEB sporulation membrane protein MutS_V PF00488.21 EFA84229.1 - 1.4e-70 237.2 0.1 2.5e-70 236.3 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFA84229.1 - 9e-32 110.8 3.3 9e-32 110.8 3.3 3.6 4 2 0 4 4 4 1 MutS domain III MutS_I PF01624.20 EFA84229.1 - 4e-28 97.9 0.2 1.2e-27 96.3 0.2 1.9 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EFA84229.1 - 7.4e-10 39.2 2.5 8.7e-09 35.8 2.5 3.0 1 1 0 1 1 1 1 MutS domain II NAGLU PF05089.12 EFA84230.1 - 6e-135 449.5 6.7 9.6e-135 448.8 6.7 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 EFA84230.1 - 8.3e-67 225.5 14.3 1.4e-66 224.8 14.3 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 EFA84230.1 - 1.8e-17 62.9 0.0 4.4e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain RNA_lig_T4_1 PF09511.10 EFA84232.1 - 5.5e-39 134.3 0.1 1.2e-38 133.1 0.1 1.6 1 0 0 1 1 1 1 RNA ligase Aminotran_1_2 PF00155.21 EFA84232.1 - 7.1e-24 84.6 0.0 1.4e-23 83.6 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II RNA_ligase PF09414.10 EFA84232.1 - 0.00013 22.3 0.0 0.00073 19.9 0.0 2.1 1 1 0 1 1 1 1 RNA ligase DegT_DnrJ_EryC1 PF01041.17 EFA84232.1 - 0.043 13.1 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Mlh1_C PF16413.5 EFA84233.1 - 1.6e-81 273.7 0.1 1.6e-81 273.7 0.1 2.1 2 0 0 2 2 2 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EFA84233.1 - 1.4e-23 82.8 0.1 1.6e-22 79.4 0.0 2.4 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFA84233.1 - 4e-11 42.9 3.8 4.1e-11 42.9 0.0 2.6 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFA84233.1 - 2.2e-06 28.2 0.0 5.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Menin PF05053.13 EFA84233.1 - 2.6 6.3 14.7 5.5 5.2 14.7 1.6 1 0 0 1 1 1 0 Menin Thioredoxin PF00085.20 EFA84237.1 - 0.0038 17.2 0.1 0.0049 16.8 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFA84237.1 - 0.016 15.7 0.1 0.019 15.4 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin PF00085.20 EFA84239.1 - 0.001 19.1 0.2 0.0012 18.8 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFA84239.1 - 0.022 15.2 0.1 0.027 14.9 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain Glutaredoxin PF00462.24 EFA84239.1 - 0.065 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Glutaredoxin Glyco_hydro_32N PF00251.20 EFA84240.1 - 0.052 13.1 0.5 0.085 12.4 0.2 1.5 1 1 1 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain SAM35 PF10806.8 EFA84240.1 - 0.052 13.8 0.3 0.074 13.3 0.1 1.4 2 0 0 2 2 2 0 SAM35, subunit of SAM coomplex PhoU_div PF01865.16 EFA84241.1 - 0.036 13.4 1.6 0.042 13.2 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF47 DUF4342 PF14242.6 EFA84242.1 - 1.2 9.2 3.5 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Coiled PF05710.12 EFA84244.1 - 4e-06 27.6 3.5 4.1e-06 27.5 3.5 1.2 1 0 0 1 1 1 1 Coiled coil TPR_17 PF13431.6 EFA84246.1 - 1.8e-51 168.9 12.5 4.2e-11 42.4 0.0 8.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84246.1 - 2.9e-14 52.5 18.0 0.0028 17.3 0.0 8.3 9 0 0 9 9 9 6 TPR repeat RNase_PH_C PF03725.15 EFA84246.1 - 0.0085 16.1 0.9 0.35 10.9 0.1 3.3 3 0 0 3 3 3 1 3' exoribonuclease family, domain 2 Acyl_CoA_thio PF02551.15 EFA84246.1 - 0.14 12.0 0.0 1.1 9.1 0.0 2.5 3 1 1 4 4 4 0 Acyl-CoA thioesterase TPR_8 PF13181.6 EFA84246.1 - 2.4 8.6 8.5 51 4.4 0.0 6.7 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFA84246.1 - 9.7 6.2 15.4 5.1 7.1 0.4 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat PAC2 PF09754.9 EFA84247.1 - 1.5e-23 83.9 0.0 2e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 PAC2 family STAS PF01740.21 EFA84247.1 - 0.013 15.2 0.0 0.02 14.5 0.0 1.5 1 1 0 1 1 1 0 STAS domain Glyco_transf_20 PF00982.21 EFA84249.1 - 9.1e-186 618.2 0.0 1.1e-185 617.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFA84249.1 - 4.9e-35 120.8 0.0 9.4e-35 119.8 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Glycos_transf_1 PF00534.20 EFA84249.1 - 0.00045 19.8 0.1 0.0037 16.8 0.1 2.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 HSCB_C PF07743.13 EFA84251.1 - 2.4e-19 69.6 3.3 5e-19 68.6 3.3 1.5 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EFA84251.1 - 2.6e-05 24.2 0.1 6.7e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain DUF3636 PF12331.8 EFA84251.1 - 0.023 14.5 6.9 0.03 14.2 5.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) Endonuclease_7 PF02945.15 EFA84251.1 - 0.04 13.8 1.1 0.1 12.5 1.1 1.6 1 0 0 1 1 1 0 Recombination endonuclease VII DZR PF12773.7 EFA84251.1 - 0.17 11.9 2.5 0.38 10.8 2.5 1.5 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 EFA84251.1 - 0.75 10.6 10.6 0.14 12.9 6.2 2.2 2 0 0 2 2 2 0 zinc-ribbon family HscB_4_cys PF18256.1 EFA84251.1 - 4.9 7.1 5.8 11 6.0 5.8 1.6 1 1 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif Shisa PF13908.6 EFA84252.1 - 0.056 13.7 0.1 0.057 13.7 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PP_M1 PF03012.14 EFA84252.1 - 0.11 12.1 1.3 0.12 11.9 1.3 1.0 1 0 0 1 1 1 0 Phosphoprotein FNIP PF05725.12 EFA84253.1 - 6e-49 164.0 6.0 1.5e-13 50.7 0.2 5.8 3 3 1 5 5 5 5 FNIP Repeat F-box_5 PF18511.1 EFA84253.1 - 0.0014 18.2 0.4 0.0026 17.3 0.4 1.5 1 0 0 1 1 1 1 F-box F-box PF00646.33 EFA84253.1 - 0.0049 16.7 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA84253.1 - 0.0069 16.3 0.8 0.015 15.2 0.8 1.5 1 0 0 1 1 1 1 F-box-like PNRC PF15365.6 EFA84253.1 - 0.88 9.5 5.9 2 8.4 5.9 1.6 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif AAA_25 PF13481.6 EFA84255.1 - 0.0012 18.4 0.0 1.5 8.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EFA84255.1 - 0.0036 16.7 0.0 2.7 7.3 0.0 2.5 3 0 0 3 3 3 2 KaiC DUF2075 PF09848.9 EFA84255.1 - 0.017 14.3 0.8 0.028 13.7 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 EFA84255.1 - 0.063 13.8 1.1 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 EFA84255.1 - 0.13 11.7 2.7 0.26 10.8 0.2 2.2 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Podoplanin PF05808.11 EFA84260.1 - 2.8e-07 30.8 0.0 2.8e-07 30.8 0.0 2.7 2 1 0 2 2 2 1 Podoplanin DUF4690 PF15756.5 EFA84260.1 - 0.0085 16.7 2.3 0.012 16.1 0.0 2.5 3 0 0 3 3 3 1 Small Novel Rich in Cartilage CYYR1 PF10873.8 EFA84260.1 - 0.021 15.3 0.0 0.065 13.7 0.0 1.8 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 EphA2_TM PF14575.6 EFA84260.1 - 0.15 13.0 0.1 0.47 11.4 0.1 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Podoplanin PF05808.11 EFA84263.1 - 4.4e-08 33.4 0.3 4.4e-08 33.4 0.3 2.3 2 1 0 2 2 2 1 Podoplanin DUF4690 PF15756.5 EFA84263.1 - 0.00078 20.0 0.2 0.0036 17.9 0.0 2.2 2 0 0 2 2 2 1 Small Novel Rich in Cartilage LRR_6 PF13516.6 EFA84263.1 - 0.28 11.3 2.9 8.9 6.7 0.1 3.8 3 0 0 3 3 3 0 Leucine Rich repeat Erp_C PF06780.11 EFA84264.1 - 0.0027 17.7 2.7 0.14 12.2 0.4 2.3 2 0 0 2 2 2 2 Erp protein C-terminus GvpG PF05120.12 EFA84265.1 - 0.026 14.5 1.4 0.061 13.3 0.5 2.1 2 1 0 2 2 2 0 Gas vesicle protein G EF-hand_5 PF13202.6 EFA84265.1 - 0.026 14.0 0.1 0.063 12.8 0.1 1.6 1 0 0 1 1 1 0 EF hand UBX PF00789.20 EFA84265.1 - 0.057 13.6 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 UBX domain Tropomyosin PF00261.20 EFA84265.1 - 0.13 11.6 5.8 0.04 13.3 2.4 1.8 2 0 0 2 2 2 0 Tropomyosin AAA_23 PF13476.6 EFA84265.1 - 2.6 8.5 18.0 0.35 11.3 7.2 2.1 1 1 0 2 2 2 0 AAA domain Acyltransferase PF01553.21 EFA84269.1 - 5.2e-17 61.7 0.0 9.4e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase YesK PF14150.6 EFA84269.1 - 0.013 15.7 0.6 0.031 14.5 0.6 1.7 1 0 0 1 1 1 0 YesK-like protein PROCT PF08084.11 EFA84269.1 - 0.013 15.4 0.4 0.2 11.6 0.1 2.4 2 0 0 2 2 2 0 PROCT (NUC072) domain Cytochrom_B_C PF00032.17 EFA84269.1 - 0.29 11.4 4.6 1.4 9.2 1.1 2.3 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Synaptobrevin PF00957.21 EFA84270.1 - 5.6e-23 80.6 4.9 6.7e-23 80.3 4.9 1.0 1 0 0 1 1 1 1 Synaptobrevin MG1 PF17790.1 EFA84270.1 - 0.036 14.5 0.9 0.042 14.3 0.9 1.1 1 0 0 1 1 1 0 Macroglobulin domain MG1 DUF3560 PF12083.8 EFA84270.1 - 0.065 13.4 0.2 0.08 13.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3560) HTH_psq PF05225.16 EFA84271.1 - 0.098 12.4 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain LMBR1 PF04791.16 EFA84271.1 - 0.63 8.9 3.7 0.9 8.4 3.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein NIF PF03031.18 EFA84272.1 - 9.2e-54 181.4 0.5 2.5e-53 180.0 0.5 1.8 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FSA_C PF10479.9 EFA84272.1 - 8.1 4.4 17.7 12 3.8 17.7 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus tRNA-synt_1b PF00579.25 EFA84273.1 - 4.5e-68 229.7 1.7 8.6e-68 228.8 1.7 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) zf-CDGSH PF09360.10 EFA84273.1 - 2.2e-07 31.0 0.7 2.2e-07 31.0 0.7 2.5 2 1 0 2 2 2 1 Iron-binding zinc finger CDGSH type VIT1 PF01988.19 EFA84274.1 - 6.6e-11 42.5 0.0 1.1e-10 41.8 0.0 1.4 1 1 0 1 1 1 1 VIT family Cation_efflux PF01545.21 EFA84274.1 - 0.0009 19.0 0.2 0.0013 18.6 0.2 1.1 1 0 0 1 1 1 1 Cation efflux family PGG PF13962.6 EFA84274.1 - 0.042 13.7 0.1 0.07 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function YqzM PF14141.6 EFA84274.1 - 0.4 10.8 2.3 7.8 6.6 0.3 2.6 2 0 0 2 2 2 0 YqzM-like protein Cyt-b5 PF00173.28 EFA84275.1 - 6.6e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Presenilin PF01080.17 EFA84275.1 - 0.11 11.2 6.1 0.13 11.0 6.1 1.1 1 0 0 1 1 1 0 Presenilin Paramyxo_ncap PF00973.19 EFA84275.1 - 0.91 8.4 7.2 1.2 7.9 7.2 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein TPX2 PF06886.11 EFA84275.1 - 3.3 8.0 12.5 1.2 9.4 0.6 2.5 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) Hydin_ADK PF17213.3 EFA84275.1 - 9.4 6.5 11.3 14 5.9 11.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Actin PF00022.19 EFA84276.1 - 6.1e-139 463.1 0.0 7e-139 462.9 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFA84276.1 - 0.00047 19.1 0.0 0.0081 15.0 0.0 2.2 2 1 0 2 2 2 1 MreB/Mbl protein Metallophos PF00149.28 EFA84277.1 - 3.5e-16 60.3 2.4 5.3e-16 59.7 2.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf-B_box PF00643.24 EFA84278.1 - 4.5e-09 36.3 10.6 9.4e-09 35.3 10.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Ub-Mut7C PF14451.6 EFA84278.1 - 0.15 12.0 0.2 0.74 9.7 0.2 2.2 1 1 0 1 1 1 0 Mut7-C ubiquitin Metallophos PF00149.28 EFA84279.1 - 1.1e-13 52.2 1.3 1.6e-13 51.6 1.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SNF2_N PF00176.23 EFA84280.1 - 5.6e-24 84.5 0.0 5.6e-24 84.5 0.0 2.3 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA84280.1 - 1.6e-12 47.7 0.0 9e-12 45.3 0.0 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-GRF PF06839.12 EFA84280.1 - 0.021 14.9 0.1 0.069 13.3 0.1 2.0 1 0 0 1 1 1 0 GRF zinc finger TMEM154 PF15102.6 EFA84281.1 - 3.3e-05 23.8 0.0 8.3e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 EFA84281.1 - 0.00042 20.3 1.4 0.00044 20.2 0.1 1.7 2 0 0 2 2 2 1 Rifin EphA2_TM PF14575.6 EFA84281.1 - 0.00043 21.1 0.1 0.0012 19.7 0.1 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain CBM_14 PF01607.24 EFA84281.1 - 0.0052 16.9 9.7 0.61 10.3 2.5 3.2 1 1 1 2 2 2 2 Chitin binding Peritrophin-A domain ASFV_J13L PF05568.11 EFA84281.1 - 0.0053 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 African swine fever virus J13L protein KCH PF16944.5 EFA84281.1 - 0.0091 15.8 0.4 0.018 14.8 0.4 1.4 1 0 0 1 1 1 1 Fungal potassium channel ECSCR PF15820.5 EFA84281.1 - 0.041 13.7 0.6 0.13 12.2 0.6 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator OAD_gamma PF04277.13 EFA84281.1 - 0.042 14.4 0.5 0.081 13.5 0.5 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4006 PF13179.6 EFA84281.1 - 0.045 13.7 0.3 0.15 12.0 0.3 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF4006) Orf78 PF06024.12 EFA84281.1 - 0.048 14.0 0.5 0.048 14.0 0.5 2.5 2 0 0 2 2 2 0 Orf78 (ac78) TRP PF06011.12 EFA84281.1 - 0.054 12.2 0.5 0.11 11.1 0.2 1.6 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel Protocadherin PF08374.11 EFA84281.1 - 0.065 13.2 0.6 0.12 12.4 0.6 1.4 1 0 0 1 1 1 0 Protocadherin DUF4736 PF15883.5 EFA84281.1 - 0.079 12.7 0.4 0.18 11.5 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) Neur_chan_memb PF02932.16 EFA84281.1 - 0.083 12.9 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4834 PF16118.5 EFA84281.1 - 0.091 13.7 8.9 1.3 10.0 8.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Baculo_11_kDa PF06143.11 EFA84281.1 - 0.097 12.3 1.8 0.31 10.7 1.8 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF5305 PF17231.2 EFA84281.1 - 0.11 11.9 2.5 0.094 12.1 0.5 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5305) SIT PF15330.6 EFA84281.1 - 0.11 12.9 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Peptidase_S49_N PF08496.10 EFA84281.1 - 0.2 11.7 1.4 0.22 11.6 0.1 1.7 2 0 0 2 2 1 0 Peptidase family S49 N-terminal HPS3_Mid PF14762.6 EFA84282.1 - 2.8e-33 115.2 9.0 2.8e-33 115.2 9.0 1.7 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.6 EFA84282.1 - 6.7e-29 100.9 0.1 1.3e-27 96.7 0.0 2.8 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3 HPS3_C PF14763.6 EFA84282.1 - 3.4e-05 23.4 0.9 0.00035 20.0 0.3 2.2 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3, C-terminal EPL1 PF10513.9 EFA84282.1 - 0.018 15.4 1.5 0.82 10.0 0.2 2.7 2 0 0 2 2 2 0 Enhancer of polycomb-like SUIM_assoc PF16619.5 EFA84282.1 - 0.024 14.7 5.4 1.7 8.8 0.7 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 EFA84282.1 - 1.2 9.1 12.1 0.91 9.5 3.6 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2547 PF10818.8 EFA84282.1 - 4.9 8.1 13.7 3.6 8.6 5.9 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2547) Ank_2 PF12796.7 EFA84283.1 - 2.7e-06 27.8 0.4 0.00035 21.1 0.2 2.2 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84283.1 - 3.3e-05 23.9 0.0 5.1 8.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFA84283.1 - 0.0004 20.9 0.1 0.045 14.3 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84283.1 - 0.00079 19.7 0.2 4.7 7.7 0.0 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Lipase_GDSL_3 PF14606.6 EFA84283.1 - 0.034 14.3 0.7 0.058 13.5 0.7 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF4798 PF16055.5 EFA84283.1 - 3.8 7.8 5.8 0.49 10.7 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4798) Ank_2 PF12796.7 EFA84284.1 - 7.9e-26 90.5 14.2 7.9e-07 29.6 0.1 8.1 2 2 7 10 10 10 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84284.1 - 3.9e-24 84.7 2.3 0.0071 16.9 0.0 10.8 7 4 3 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84284.1 - 9.7e-17 59.4 3.3 9.1 7.2 0.0 12.7 13 0 0 13 13 13 3 Ankyrin repeat Ank_5 PF13857.6 EFA84284.1 - 5.3e-14 52.1 6.9 2.8 8.4 0.0 11.0 7 4 6 13 13 13 5 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA84284.1 - 0.0021 18.0 19.8 2.2 8.3 0.1 6.7 5 3 3 8 8 8 3 Domain of unknown function (DUF3447) Asp_decarbox PF02261.16 EFA84284.1 - 0.019 14.9 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 Aspartate decarboxylase Colicin_V PF02674.16 EFA84285.1 - 0.13 12.2 11.2 0.054 13.5 4.5 2.3 1 1 0 2 2 2 0 Colicin V production protein HTH_23 PF13384.6 EFA84287.1 - 2.7e-08 33.4 0.0 2.7e-08 33.4 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain Sigma70_r4 PF04545.16 EFA84287.1 - 6.8e-06 25.5 0.3 4.8e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_28 PF13518.6 EFA84287.1 - 7.3e-06 26.0 0.0 1.9e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain CENP-B_N PF04218.13 EFA84287.1 - 1.7e-05 24.4 0.3 1.7e-05 24.4 0.3 2.4 2 1 1 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 EFA84287.1 - 0.00042 20.0 1.3 0.00073 19.2 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 EFA84287.1 - 0.00066 19.6 0.8 0.0015 18.5 0.0 2.1 3 1 0 3 3 3 1 Winged helix-turn helix HTH_33 PF13592.6 EFA84287.1 - 0.0023 17.5 0.0 0.0095 15.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix MarR PF01047.22 EFA84287.1 - 0.0032 17.3 0.5 1.2 9.1 0.0 2.4 2 0 0 2 2 2 2 MarR family HTH_Tnp_Tc3_2 PF01498.18 EFA84287.1 - 0.0035 17.5 1.7 0.027 14.7 0.5 2.4 2 1 0 2 2 2 1 Transposase GerE PF00196.19 EFA84287.1 - 0.0095 15.5 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_3 PF01381.22 EFA84287.1 - 0.011 15.8 0.1 0.052 13.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix HTH_Tnp_4 PF13613.6 EFA84287.1 - 0.03 14.1 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Peptidase_M28 PF04389.17 EFA84287.1 - 0.031 14.0 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M28 HTH_32 PF13565.6 EFA84287.1 - 0.049 14.2 0.7 0.22 12.2 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain Citrate_synt PF00285.21 EFA84289.1 - 4.1e-89 299.2 0.0 1.3e-85 287.7 0.0 2.0 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Phage_cap_E PF03864.15 EFA84289.1 - 0.074 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein E Glyoxalase_4 PF13669.6 EFA84290.1 - 2.8e-20 72.6 0.0 3.4e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 EFA84290.1 - 1.5e-10 41.4 0.0 1.6e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFA84290.1 - 3.4e-07 30.5 0.0 4.2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EFA84290.1 - 0.1 12.6 0.1 0.47 10.4 0.1 2.1 1 1 0 1 1 1 0 Glyoxalase-like domain DUF1338 PF07063.13 EFA84290.1 - 0.27 10.4 0.3 14 4.7 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1338) Peptidase_S9 PF00326.21 EFA84291.1 - 2.3e-38 131.8 0.0 7.5e-38 130.1 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFA84291.1 - 1.2e-10 41.1 0.0 3.4e-07 29.8 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFA84291.1 - 1.7e-08 34.6 0.0 5.3e-08 33.0 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EFA84291.1 - 2.1e-05 24.3 0.1 9e-05 22.2 0.2 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 EFA84291.1 - 0.00011 20.9 0.0 0.0029 16.3 0.0 3.0 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 EFA84291.1 - 0.00042 19.9 0.0 0.004 16.7 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EFA84291.1 - 0.00062 20.4 0.9 0.0011 19.7 0.9 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EFA84291.1 - 0.007 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EFA84291.1 - 0.038 13.6 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF2920 PF11144.8 EFA84291.1 - 0.096 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Tim17 PF02466.19 EFA84293.1 - 4.1e-12 46.5 8.4 5e-12 46.2 8.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family T-box_assoc PF16176.5 EFA84293.1 - 0.063 13.4 0.3 0.079 13.0 0.3 1.2 1 0 0 1 1 1 0 T-box transcription factor-associated Romo1 PF10247.9 EFA84293.1 - 1.1 9.7 13.2 0.14 12.6 1.4 3.0 2 1 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Gly-zipper_YMGG PF13441.6 EFA84293.1 - 7.9 6.3 15.8 0.67 9.7 8.1 2.3 2 0 0 2 2 2 0 YMGG-like Gly-zipper Ribosomal_L23 PF00276.20 EFA84294.1 - 2.6e-14 53.4 3.4 2.6e-14 53.4 3.4 3.1 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EFA84294.1 - 4e-13 49.4 8.8 4e-13 49.4 8.8 2.7 1 1 2 3 3 3 1 Ribosomal protein L23, N-terminal domain YihI PF04220.12 EFA84294.1 - 0.063 13.0 0.3 0.14 11.9 0.3 1.7 1 1 0 1 1 1 0 Der GTPase activator (YihI) MAP65_ASE1 PF03999.12 EFA84294.1 - 0.69 8.5 6.5 0.83 8.3 6.5 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) G-patch PF01585.23 EFA84295.1 - 3.8e-10 39.5 0.7 1.2e-09 37.9 0.7 1.9 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFA84295.1 - 0.0005 20.1 1.0 0.0005 20.1 1.0 5.2 5 0 0 5 5 5 1 G-patch domain Utp14 PF04615.13 EFA84295.1 - 1.8 7.0 69.0 2.4 6.6 69.0 1.1 1 0 0 1 1 1 0 Utp14 protein SEP PF08059.13 EFA84296.1 - 4.2e-25 88.1 0.0 1.2e-24 86.7 0.0 1.9 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 EFA84296.1 - 1.7e-13 50.2 0.1 2.9e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFA84296.1 - 1.8e-13 50.4 0.0 3.3e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 UBX domain Misat_Tub_SegII PF10644.9 EFA84296.1 - 0.078 13.3 0.7 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain Mucin PF01456.17 EFA84296.1 - 1.5 8.8 19.5 3.1 7.8 19.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein CMV_1a PF12467.8 EFA84296.1 - 2.2 8.6 5.8 4.9 7.5 5.8 1.5 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family UPF0560 PF10577.9 EFA84296.1 - 3.4 6.1 9.6 0.043 12.3 2.3 1.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 INTS5_C PF14838.6 EFA84297.1 - 9e-23 80.8 36.6 1.4e-22 80.1 0.6 2.9 3 0 0 3 3 3 2 Integrator complex subunit 5 C-terminus DUF1129 PF06570.11 EFA84298.1 - 0.041 13.4 0.1 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Ank_4 PF13637.6 EFA84299.1 - 6.5e-08 33.0 0.1 0.00017 22.1 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84299.1 - 3.9e-07 30.5 0.1 1.1e-06 29.1 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) F-box-like PF12937.7 EFA84299.1 - 6.7e-06 25.9 0.2 1.8e-05 24.5 0.2 1.8 1 0 0 1 1 1 1 F-box-like Ank_5 PF13857.6 EFA84299.1 - 1e-05 25.7 0.0 0.00023 21.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA84299.1 - 2.7e-05 24.4 0.1 0.014 15.8 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EFA84299.1 - 0.04 14.5 0.2 2.3 9.1 0.0 3.7 3 1 0 3 3 3 0 Ankyrin repeat T2SSS_2 PF16549.5 EFA84299.1 - 0.12 12.4 0.5 2 8.5 0.2 2.6 2 0 0 2 2 2 0 Type II secretion system (T2SS) pilotin, S protein Vinculin PF01044.19 EFA84300.1 - 2e-16 59.5 133.0 1.5e-10 40.0 44.0 7.7 3 3 1 4 4 4 2 Vinculin family F_actin_bind PF08919.10 EFA84300.1 - 0.004 17.2 2.6 0.004 17.2 2.6 10.9 12 1 1 13 13 13 3 F-actin binding GHMP_kinases_C PF08544.13 EFA84300.1 - 0.27 11.6 5.3 5.6 7.4 0.0 5.1 4 0 0 4 4 4 0 GHMP kinases C terminal DUF4363 PF14276.6 EFA84300.1 - 5.7 7.1 49.4 0.89 9.7 1.0 11.5 10 2 1 11 11 11 0 Domain of unknown function (DUF4363) CTD_bind PF04818.13 EFA84302.1 - 0.00055 20.7 1.3 0.00055 20.7 1.3 2.4 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Ndc1_Nup PF09531.10 EFA84302.1 - 0.015 14.0 14.6 0.018 13.8 14.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 EFA84302.1 - 1.3 7.3 48.2 1.5 7.0 48.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 EFA84302.1 - 3.7 6.2 26.8 5.3 5.7 26.8 1.3 1 0 0 1 1 1 0 Presenilin LSM PF01423.22 EFA84303.1 - 0.0046 16.6 0.0 0.0065 16.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA84303.1 - 0.018 15.2 0.2 0.03 14.4 0.1 1.6 1 1 1 2 2 2 0 Ataxin 2 SM domain Zn_peptidase_2 PF04298.12 EFA84305.1 - 6.8 6.0 11.3 0.67 9.3 0.5 2.7 1 1 1 3 3 3 0 Putative neutral zinc metallopeptidase Kelch_6 PF13964.6 EFA84306.1 - 4.2e-14 52.3 9.3 1e-07 32.0 0.4 5.2 4 1 1 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA84306.1 - 0.0003 20.9 10.5 0.00079 19.5 10.5 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_1 PF01344.25 EFA84306.1 - 0.36 10.5 4.6 1.1 8.9 0.4 3.2 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 EFA84306.1 - 4.4 7.4 9.4 20 5.3 1.0 4.3 5 0 0 5 5 5 0 Galactose oxidase, central domain Pkinase PF00069.25 EFA84307.1 - 1.6e-37 129.3 0.0 1.6e-37 129.3 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84307.1 - 6.6e-19 68.2 0.0 1.5e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Ribonuc_2-5A PF06479.12 EFA84307.1 - 8.3e-18 64.8 9.3 8.3e-18 64.8 9.3 2.4 2 0 0 2 2 2 1 Ribonuclease 2-5A Kdo PF06293.14 EFA84307.1 - 0.012 15.0 0.7 0.14 11.5 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA84307.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFA84308.1 - 4.8e-37 127.8 0.0 4.8e-37 127.8 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84308.1 - 5.8e-19 68.4 0.0 1.1e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ribonuc_2-5A PF06479.12 EFA84308.1 - 1.2e-17 64.3 6.0 4.1e-17 62.5 6.0 1.9 1 0 0 1 1 1 1 Ribonuclease 2-5A Kinase-like PF14531.6 EFA84308.1 - 0.014 14.8 0.0 0.032 13.6 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Macoilin PF09726.9 EFA84308.1 - 0.017 13.8 24.4 0.03 12.9 24.4 1.3 1 0 0 1 1 1 0 Macoilin family Kdo PF06293.14 EFA84308.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFA84308.1 - 0.096 12.6 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1387 PF07139.11 EFA84308.1 - 3.3 7.4 39.4 0.076 12.7 28.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1387) TFIIF_alpha PF05793.12 EFA84308.1 - 8.9 4.8 35.7 14 4.1 35.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Arf PF00025.21 EFA84311.1 - 2.1e-58 196.6 0.3 2.5e-58 196.4 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA84311.1 - 3.4e-13 49.8 0.0 4.6e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA84311.1 - 5.6e-12 45.5 0.0 6.8e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA84311.1 - 7.6e-12 45.1 0.0 8.3e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFA84311.1 - 3.4e-09 36.4 0.0 4.2e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA84311.1 - 8.1e-07 28.5 1.0 0.0018 17.5 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MeaB PF03308.16 EFA84311.1 - 8.6e-05 21.6 1.4 0.67 8.9 0.0 3.0 1 1 2 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 EFA84311.1 - 0.00016 21.7 0.2 0.3 11.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA84311.1 - 0.00028 20.9 0.1 0.00046 20.2 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EFA84311.1 - 0.014 15.6 0.2 0.12 12.5 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFA84311.1 - 0.016 14.7 0.1 0.027 14.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFA84311.1 - 0.039 13.3 0.1 0.067 12.6 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EFA84311.1 - 0.058 13.3 0.4 0.66 9.9 0.3 2.0 2 0 0 2 2 2 0 NTPase SRP54 PF00448.22 EFA84311.1 - 0.066 12.8 0.3 0.12 11.9 0.2 1.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Sigma54_activat PF00158.26 EFA84311.1 - 0.075 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EFA84311.1 - 0.09 12.5 0.5 0.44 10.3 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EFA84311.1 - 0.1 13.1 0.2 0.23 12.0 0.2 1.5 1 1 0 1 1 1 0 AAA domain EF-hand_1 PF00036.32 EFA84312.1 - 6.9e-17 59.7 3.4 1.7e-05 24.0 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFA84312.1 - 5.5e-15 53.9 1.3 0.00021 20.9 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EFA84312.1 - 3.7e-14 52.9 0.5 2.6e-07 31.0 0.2 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFA84312.1 - 1.2e-13 49.9 1.9 0.00018 20.8 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFA84312.1 - 4.9e-11 42.3 5.7 3.9e-06 26.6 0.1 3.6 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFA84312.1 - 3.2e-07 30.7 0.1 0.018 15.3 0.0 3.1 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFA84312.1 - 0.0016 18.7 0.1 0.0075 16.6 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 EFA84312.1 - 0.01 16.0 0.2 1.5 9.1 0.2 2.3 2 0 0 2 2 2 0 Dockerin type I domain EF-hand_4 PF12763.7 EFA84312.1 - 0.017 15.0 0.7 7.4 6.6 0.0 2.7 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EFA84312.1 - 0.084 12.8 0.8 2.4 8.1 0.0 2.7 2 0 0 2 2 2 0 EF hand Trehalase_Ca-bi PF07492.11 EFA84312.1 - 0.097 12.4 1.5 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Neutral trehalase Ca2+ binding domain DUF4964 PF16334.5 EFA84312.1 - 0.2 11.2 0.0 0.89 9.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4964) SprB PF13573.6 EFA84312.1 - 3.8 7.4 5.4 5.8 6.8 0.8 2.4 2 0 0 2 2 2 0 SprB repeat SANT_DAMP1_like PF16282.5 EFA84313.1 - 1.1e-27 96.0 5.4 4.2e-27 94.2 5.4 2.0 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 EFA84313.1 - 0.00071 19.7 0.0 0.0022 18.1 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain ADP_ribosyl_GH PF03747.14 EFA84314.1 - 1e-62 212.6 0.0 1.2e-62 212.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Sod_Ni PF09055.11 EFA84314.1 - 0.03 14.9 0.2 0.069 13.7 0.2 1.5 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase Rick_17kDa_Anti PF05433.15 EFA84314.1 - 0.11 12.4 0.3 0.23 11.3 0.3 1.6 1 0 0 1 1 1 0 Glycine zipper 2TM domain DUF2318 PF10080.9 EFA84315.1 - 0.00091 19.3 1.4 0.78 9.9 0.2 2.3 2 0 0 2 2 2 2 Predicted membrane protein (DUF2318) Ribosomal_L37ae PF01780.19 EFA84315.1 - 0.21 11.7 10.8 1.1 9.4 2.0 3.3 3 0 0 3 3 3 0 Ribosomal L37ae protein family zinc-ribbons_6 PF07191.12 EFA84315.1 - 0.36 10.8 8.7 3.3 7.8 1.6 2.3 2 0 0 2 2 2 0 zinc-ribbons FYVE PF01363.21 EFA84315.1 - 0.74 10.0 12.4 1.5 9.0 4.0 2.5 1 1 0 2 2 2 0 FYVE zinc finger Rpr2 PF04032.16 EFA84315.1 - 1.9 8.8 16.2 8 6.8 0.1 4.3 3 1 0 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain HypA PF01155.19 EFA84315.1 - 2.7 8.1 8.9 8.2 6.5 1.8 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 EFA84315.1 - 3 7.8 13.6 1.2 9.1 2.6 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain ADK_lid PF05191.14 EFA84315.1 - 6.1 6.9 7.3 20 5.2 0.0 3.8 4 0 0 4 4 4 0 Adenylate kinase, active site lid FYVE_2 PF02318.16 EFA84315.1 - 7.4 6.8 8.9 20 5.4 1.0 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger Prim_Zn_Ribbon PF08273.12 EFA84315.1 - 9.6 6.6 14.3 0.86 9.9 8.3 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF3767 PF12597.8 EFA84316.1 - 6.2e-13 48.4 0.0 8e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) ADH_zinc_N_2 PF13602.6 EFA84317.1 - 1.7e-18 67.9 0.0 3.8e-18 66.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFA84317.1 - 5.8e-07 29.5 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA84317.1 - 3.9e-06 26.7 0.0 6.9e-05 22.7 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Semialdhyde_dh PF01118.24 EFA84317.1 - 0.016 15.7 0.0 0.053 14.0 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Pigment_DH PF06324.11 EFA84317.1 - 0.034 14.2 0.6 0.095 12.8 0.6 1.8 1 1 0 1 1 1 0 Pigment-dispersing hormone (PDH) Uma2 PF05685.12 EFA84319.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative restriction endonuclease Mito_carr PF00153.27 EFA84322.1 - 3.7e-34 116.5 2.1 3.6e-16 58.8 0.0 3.0 2 1 0 2 2 2 2 Mitochondrial carrier protein Mito_carr PF00153.27 EFA84323.1 - 2.9e-51 171.3 3.4 9.8e-19 67.1 0.3 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein COG5 PF10392.9 EFA84323.1 - 0.00014 22.0 0.2 0.00045 20.4 0.2 1.9 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Sec5 PF15469.6 EFA84323.1 - 0.0017 18.2 9.5 0.0072 16.2 9.5 2.2 1 1 0 1 1 1 1 Exocyst complex component Sec5 Vps54_N PF10475.9 EFA84323.1 - 0.09 12.0 6.5 0.16 11.2 5.4 1.8 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Mitofilin PF09731.9 EFA84323.1 - 8.4 5.1 23.8 0.7 8.7 18.7 1.6 2 0 0 2 2 2 0 Mitochondrial inner membrane protein DUF1764 PF08576.10 EFA84323.1 - 9.4 7.2 24.4 1.5 9.7 0.4 3.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Sec15 PF04091.12 EFA84324.1 - 1.5e-47 162.6 9.9 1.7e-47 162.4 9.9 1.0 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like DUF4746 PF15928.5 EFA84326.1 - 0.022 14.2 2.5 0.022 14.2 2.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF4199 PF13858.6 EFA84327.1 - 0.017 15.5 1.1 0.022 15.2 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF1980 PF09323.10 EFA84327.1 - 0.69 9.8 3.3 0.72 9.7 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) Glyco_hydro_47 PF01532.20 EFA84328.1 - 9.6e-85 285.2 0.0 1.3e-84 284.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_47 PF01532.20 EFA84329.1 - 4.2e-12 45.7 1.4 5.5e-12 45.3 0.8 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 47 p450 PF00067.22 EFA84330.1 - 0.029 13.1 0.0 0.044 12.5 0.0 1.3 1 0 0 1 1 1 0 Cytochrome P450 p450 PF00067.22 EFA84331.1 - 6.6e-90 302.1 0.0 3.7e-83 279.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 CofC PF01983.16 EFA84331.1 - 0.096 11.8 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 Guanylyl transferase CofC like DUF2779 PF11074.8 EFA84333.1 - 0.003 18.0 1.4 0.015 15.7 0.2 2.2 1 1 1 2 2 2 1 Domain of unknown function(DUF2779) LepB_GAP_C PF18227.1 EFA84333.1 - 0.0069 16.9 0.1 0.029 14.9 0.1 2.2 2 0 0 2 2 2 1 LepB GAP domain C-terminal subdomain Stork_head PF10264.9 EFA84335.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain E3_UFM1_ligase PF09743.9 EFA84337.1 - 1.3e-102 343.1 10.2 4.6e-102 341.3 10.2 2.0 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 HTH_9 PF08221.11 EFA84337.1 - 0.04 14.0 0.0 0.18 11.9 0.0 2.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Arc_C PF18162.1 EFA84337.1 - 0.047 13.5 1.4 2.9 7.8 0.1 3.0 2 0 0 2 2 2 0 Arc C-lobe B-block_TFIIIC PF04182.12 EFA84337.1 - 0.052 13.7 0.9 2.3 8.4 0.1 3.3 2 1 0 2 2 2 0 B-block binding subunit of TFIIIC P5CR_dimer PF14748.6 EFA84338.1 - 2.4e-26 92.0 1.0 4.9e-26 91.0 1.0 1.6 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EFA84338.1 - 2.7e-16 59.9 0.8 7.3e-16 58.5 0.2 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EFA84338.1 - 0.00054 19.6 0.9 0.00054 19.6 0.9 2.6 2 1 0 2 2 2 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 EFA84338.1 - 0.00066 19.3 0.2 0.0014 18.3 0.2 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Sacchrp_dh_NADP PF03435.18 EFA84338.1 - 0.00081 19.7 0.1 0.00081 19.7 0.1 2.8 2 1 1 3 3 3 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EFA84338.1 - 0.0012 19.1 0.2 0.0024 18.0 0.2 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 EFA84338.1 - 0.0024 17.8 1.5 0.0088 16.0 1.5 2.0 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TFIIA PF03153.13 EFA84338.1 - 0.09 12.8 43.6 0.14 12.2 43.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC27 PF09507.10 EFA84338.1 - 0.26 10.6 43.8 0.38 10.1 43.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CCSAP PF15748.5 EFA84338.1 - 0.58 10.3 42.3 1.1 9.3 42.3 1.5 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SWI-SNF_Ssr4 PF08549.10 EFA84338.1 - 9.6 4.7 36.5 13 4.3 36.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Hamartin PF04388.12 EFA84338.1 - 9.9 4.7 31.3 16 4.0 31.3 1.3 1 0 0 1 1 1 0 Hamartin protein GRIP PF01465.20 EFA84339.1 - 0.00071 19.4 0.1 0.0024 17.8 0.1 2.0 1 0 0 1 1 1 1 GRIP domain YvrJ PF12841.7 EFA84339.1 - 3.4 7.3 4.5 15 5.2 0.5 3.9 2 0 0 2 2 2 0 YvrJ protein family NUC173 PF08161.12 EFA84340.1 - 9e-61 205.1 3.6 1.3e-60 204.6 0.7 2.8 2 0 0 2 2 2 1 NUC173 domain DUF3641 PF12345.8 EFA84340.1 - 0.019 15.0 0.3 0.065 13.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) DUF1827 PF08860.10 EFA84340.1 - 0.07 13.4 0.5 0.63 10.3 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1827) NatB_MDM20 PF09797.9 EFA84340.1 - 1.1 8.1 10.6 0.2 10.6 5.6 2.2 2 0 0 2 2 2 0 N-acetyltransferase B complex (NatB) non catalytic subunit Presenilin PF01080.17 EFA84341.1 - 2.6e-132 441.4 8.6 2.6e-132 441.4 8.6 2.3 1 1 1 2 2 2 1 Presenilin TMPIT PF07851.13 EFA84341.1 - 0.03 13.6 3.0 0.19 11.0 0.0 2.4 2 1 0 2 2 2 0 TMPIT-like protein Pex14_N PF04695.13 EFA84341.1 - 0.23 12.1 10.7 2.2 8.9 6.3 2.6 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CPP1-like PF11833.8 EFA84341.1 - 0.7 9.5 0.0 0.7 9.5 0.0 3.3 3 1 2 5 5 5 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like SAPS PF04499.15 EFA84341.1 - 2.5 6.8 8.9 1.5 7.6 0.6 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 EFA84341.1 - 4.2 6.1 12.2 5.8 5.6 6.5 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Tetraspanin PF00335.20 EFA84341.1 - 6.1 6.5 9.3 0.068 12.9 0.2 2.3 2 0 0 2 2 2 0 Tetraspanin family MID_MedPIWI PF18296.1 EFA84341.1 - 6.3 6.5 11.1 9.5 5.9 0.3 2.1 2 0 0 2 2 2 0 MID domain of medPIWI Abhydrolase_6 PF12697.7 EFA84342.1 - 1e-06 29.5 0.0 1.4e-06 29.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA84342.1 - 0.00055 19.7 0.1 0.00085 19.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LRR_8 PF13855.6 EFA84343.1 - 0.052 13.3 0.3 2.8 7.8 0.1 2.9 2 1 0 2 2 2 0 Leucine rich repeat Pex14_N PF04695.13 EFA84345.1 - 0.014 16.1 0.2 0.73 10.5 0.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region COMMD1_N PF17221.3 EFA84345.1 - 0.04 14.2 0.2 13 6.2 0.0 2.8 2 1 1 3 3 3 0 COMMD1 N-terminal domain DNA_pol_phi PF04931.13 EFA84345.1 - 5.8 4.9 20.0 0.29 9.2 1.2 2.4 2 0 0 2 2 2 0 DNA polymerase phi GH3 PF03321.13 EFA84348.1 - 0.021 13.7 0.0 0.023 13.6 0.0 1.1 1 0 0 1 1 1 0 GH3 auxin-responsive promoter Pex14_N PF04695.13 EFA84350.1 - 0.031 14.9 0.1 0.057 14.1 0.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Phage_ABA_S PF18066.1 EFA84350.1 - 0.22 12.2 0.5 9.4 7.0 0.0 2.7 2 1 0 2 2 2 0 Phage ABA sandwich domain RF-1 PF00472.20 EFA84350.1 - 0.24 11.3 2.9 0.7 9.8 0.1 2.2 2 0 0 2 2 2 0 RF-1 domain DUF4460 PF14687.6 EFA84350.1 - 0.54 10.3 5.3 2.1 8.5 2.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) Cytomega_UL84 PF06284.11 EFA84351.1 - 0.035 12.6 1.3 0.045 12.2 1.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Connexin PF00029.19 EFA84351.1 - 0.16 11.7 3.8 0.08 12.7 0.5 2.1 2 0 0 2 2 2 0 Connexin DUF3915 PF13054.6 EFA84351.1 - 0.33 11.0 3.2 0.71 9.9 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 EFA84351.1 - 0.46 8.7 8.5 0.6 8.3 8.5 1.0 1 0 0 1 1 1 0 Atrophin-1 family Phage_holin_3_6 PF07332.11 EFA84351.1 - 0.83 9.7 6.4 0.92 9.6 0.8 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III XAP5 PF04921.14 EFA84351.1 - 3 7.6 10.7 4.4 7.0 10.7 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator Trypan_PARP PF05887.11 EFA84351.1 - 8.5 6.4 9.9 16 5.5 9.9 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RVT_1 PF00078.27 EFA84352.1 - 2.5e-41 141.6 0.4 6.1e-41 140.4 0.4 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LIM PF00412.22 EFA84353.1 - 6.2e-10 39.1 4.4 1.2e-09 38.2 4.4 1.5 1 0 0 1 1 1 1 LIM domain Ribosomal_L22 PF00237.19 EFA84354.1 - 8.5e-20 70.9 0.0 1.6e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Pep1_7 PF17232.2 EFA84354.1 - 0.45 11.0 3.0 0.76 10.3 3.0 1.3 1 0 0 1 1 1 0 Elicitor peptide 1-7 DUF829 PF05705.14 EFA84355.1 - 0.00064 19.7 0.4 0.0031 17.5 0.1 2.2 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF829) Ribosomal_L38e PF01781.18 EFA84356.1 - 1.3e-27 95.7 4.8 1.4e-27 95.5 4.8 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family FmiP_Thoc5 PF09766.9 EFA84357.1 - 9.8e-25 87.6 10.3 5.7e-21 75.2 1.3 2.3 1 1 1 2 2 2 2 Fms-interacting protein/Thoc5 SUIM_assoc PF16619.5 EFA84357.1 - 0.0059 16.6 1.1 0.01 15.9 1.1 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF3947 PF13135.6 EFA84357.1 - 0.75 10.0 6.4 1.5 9.0 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) DUF2388 PF09498.10 EFA84358.1 - 0.19 11.7 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) DUF2388 PF09498.10 EFA84359.1 - 0.19 11.7 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) HA2 PF04408.23 EFA84360.1 - 3.1e-19 69.2 0.0 3.1e-19 69.2 0.0 3.9 4 0 0 4 4 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA84360.1 - 8.5e-18 64.5 0.1 2.3e-17 63.1 0.1 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFA84360.1 - 4.8e-15 55.9 0.0 2.1e-14 53.8 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA84360.1 - 1.2e-10 41.4 0.0 4.5e-10 39.6 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.22 EFA84360.1 - 4.3e-07 30.2 1.5 1.1e-05 25.7 1.5 3.1 1 1 0 1 1 1 1 RWD domain DND1_DSRM PF14709.7 EFA84360.1 - 9.8e-05 22.5 0.7 0.00028 21.1 0.7 1.9 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_22 PF13401.6 EFA84360.1 - 0.0016 18.7 6.5 0.012 15.9 0.8 3.7 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFA84360.1 - 0.0051 15.9 1.0 0.023 13.7 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.6 EFA84360.1 - 0.026 14.8 0.0 0.12 12.7 0.0 2.2 1 0 0 1 1 1 0 AAA domain dsRBD2 PF17842.1 EFA84360.1 - 0.078 13.2 0.2 0.078 13.2 0.2 5.8 4 2 1 5 5 5 0 Double-stranded RNA binding domain 2 AAA_29 PF13555.6 EFA84360.1 - 0.087 12.6 0.0 0.087 12.6 0.0 2.1 2 0 0 2 2 1 0 P-loop containing region of AAA domain SUIM_assoc PF16619.5 EFA84360.1 - 0.59 10.2 15.4 0.19 11.8 9.9 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TPR_17 PF13431.6 EFA84361.1 - 8.2e-20 69.7 0.8 4.8e-11 42.3 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84361.1 - 2.1e-09 36.9 0.4 0.00068 19.3 0.0 2.2 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 EFA84361.1 - 4.8e-05 23.0 1.4 0.85 9.5 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA84361.1 - 6e-05 22.9 0.1 6.1 7.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA84361.1 - 0.00024 21.0 0.5 1.6 9.1 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA84361.1 - 0.053 14.4 0.0 16 6.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat HEXIM PF15313.6 EFA84361.1 - 0.098 12.8 0.2 11 6.3 0.0 2.1 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein zf-RING_4 PF14570.6 EFA84364.1 - 0.006 16.3 6.8 0.0077 16.0 6.8 1.3 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ribbon_3 PF13248.6 EFA84364.1 - 0.024 14.1 7.0 0.28 10.7 0.5 2.8 2 1 0 2 2 2 0 zinc-ribbon domain DUF3797 PF12677.7 EFA84364.1 - 0.03 14.2 1.0 0.03 14.2 1.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3797) FYVE PF01363.21 EFA84364.1 - 0.048 13.8 9.6 0.15 12.2 9.6 1.8 1 1 0 1 1 1 0 FYVE zinc finger zf-C2H2_11 PF16622.5 EFA84364.1 - 0.36 10.6 0.1 0.36 10.6 0.1 3.0 3 1 0 3 3 3 0 zinc-finger C2H2-type UPF0547 PF10571.9 EFA84364.1 - 0.49 10.5 14.7 6.5 6.9 0.0 4.0 3 1 1 4 4 4 0 Uncharacterised protein family UPF0547 zinc_ribbon_4 PF13717.6 EFA84364.1 - 0.91 9.5 9.2 56 3.8 9.2 2.8 1 1 0 1 1 1 0 zinc-ribbon domain zf-AN1 PF01428.16 EFA84364.1 - 1.2 9.3 12.0 6.3 7.1 6.1 2.3 1 1 1 2 2 2 0 AN1-like Zinc finger IBR PF01485.21 EFA84364.1 - 1.4 9.2 13.6 1.2 9.5 7.0 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-B_box PF00643.24 EFA84364.1 - 4.5 7.5 10.3 1.1 9.5 4.1 2.2 2 0 0 2 2 2 0 B-box zinc finger OrfB_Zn_ribbon PF07282.11 EFA84364.1 - 9.2 6.3 11.2 1e+02 2.9 11.2 2.1 1 1 0 1 1 1 0 Putative transposase DNA-binding domain LCM PF04072.14 EFA84365.1 - 1.8e-29 103.0 0.0 3.3e-29 102.2 0.0 1.5 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase RhoGEF PF00621.20 EFA84365.1 - 0.12 12.6 2.6 1.4 9.2 0.1 2.1 2 0 0 2 2 2 0 RhoGEF domain LCM PF04072.14 EFA84366.1 - 9.8e-37 126.7 0.0 3.6e-36 124.9 0.0 1.9 2 0 0 2 2 2 1 Leucine carboxyl methyltransferase LCM PF04072.14 EFA84367.1 - 2.8e-35 122.0 0.0 3.9e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase L51_S25_CI-B8 PF05047.16 EFA84368.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ABC_tran PF00005.27 EFA84369.1 - 1.6e-35 122.6 0.1 3.9e-34 118.1 0.0 2.5 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EFA84369.1 - 7.3e-16 58.6 2.7 7.3e-16 58.6 2.7 2.6 1 1 1 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EFA84369.1 - 1.9e-07 30.7 1.7 1.2e-06 28.1 1.7 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFA84369.1 - 0.00066 19.5 15.4 0.011 15.5 0.0 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFA84369.1 - 0.00079 19.1 0.1 0.0038 16.9 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFA84369.1 - 0.0027 17.6 0.0 0.0082 16.1 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 EFA84369.1 - 0.0071 16.9 2.0 0.28 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA84369.1 - 0.0074 16.8 2.5 0.08 13.5 0.0 3.3 3 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EFA84369.1 - 0.0075 15.6 0.1 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin DUF815 PF05673.13 EFA84369.1 - 0.0087 15.2 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EFA84369.1 - 0.012 16.0 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 EFA84369.1 - 0.017 15.3 0.1 0.06 13.4 0.1 1.9 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_22 PF13401.6 EFA84369.1 - 0.029 14.7 0.0 0.071 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFA84369.1 - 0.053 13.8 1.3 0.59 10.4 0.3 2.7 2 1 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EFA84369.1 - 0.058 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 EFA84369.1 - 0.068 13.0 2.1 0.08 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 EFA84369.1 - 0.084 11.8 0.1 0.19 10.7 0.0 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EFA84369.1 - 0.092 12.1 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family ArfGap PF01412.18 EFA84369.1 - 0.097 12.8 0.0 0.097 12.8 0.0 2.4 2 1 0 2 2 1 0 Putative GTPase activating protein for Arf AAA_24 PF13479.6 EFA84369.1 - 0.1 12.3 0.0 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EFA84369.1 - 0.16 12.2 0.2 3.3 8.0 0.2 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EFA84369.1 - 0.17 12.1 0.1 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2269 PF10027.9 EFA84370.1 - 0.001 19.1 0.0 0.068 13.2 0.0 2.6 2 0 0 2 2 2 1 Predicted integral membrane protein (DUF2269) DUF3446 PF11928.8 EFA84370.1 - 2.6 8.4 6.7 31 5.0 4.1 2.6 1 1 0 2 2 2 0 Early growth response N-terminal domain AdoMet_MTase PF07757.13 EFA84371.1 - 1.1e-32 112.6 0.4 3.3e-32 111.2 0.1 1.9 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_23 PF13489.6 EFA84371.1 - 0.0028 17.5 0.8 0.018 14.9 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Menin PF05053.13 EFA84371.1 - 0.01 14.2 30.2 0.09 11.1 11.8 2.3 2 0 0 2 2 2 0 Menin Methyltransf_32 PF13679.6 EFA84371.1 - 0.054 13.5 0.0 0.054 13.5 0.0 4.6 3 2 1 4 4 4 0 Methyltransferase domain Acetyltransf_1 PF00583.25 EFA84372.1 - 3.1e-07 30.6 0.0 4.6e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA84372.1 - 7.8e-05 23.0 0.0 0.0002 21.7 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA84372.1 - 0.0029 17.6 0.0 0.0043 17.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain E1-E2_ATPase PF00122.20 EFA84373.1 - 5.5e-36 123.8 1.7 5.5e-36 123.8 1.7 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFA84373.1 - 6.3e-17 62.6 0.3 2.6e-16 60.6 0.3 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA84373.1 - 1.1e-16 60.3 0.0 3.1e-16 58.8 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 EFA84373.1 - 1.1e-16 61.1 8.3 1.1e-16 61.1 8.3 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EFA84373.1 - 1.4e-08 34.7 0.0 2.9e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFA84373.1 - 0.0017 18.2 0.3 0.052 13.3 0.1 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA84373.1 - 0.0088 16.5 0.1 0.15 12.4 0.0 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Methyltransf_11 PF08241.12 EFA84374.1 - 5.6e-16 59.0 0.0 1e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84374.1 - 2.7e-11 44.0 0.0 7.2e-11 42.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84374.1 - 4e-08 33.9 0.9 1.3e-07 32.2 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA84374.1 - 5.2e-07 29.6 0.1 6.3e-06 26.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA84374.1 - 1.1e-06 28.6 0.0 1.7e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA84374.1 - 3.5e-05 23.3 0.1 9.2e-05 21.9 0.1 1.7 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 EFA84374.1 - 0.015 13.9 0.0 0.027 13.0 0.0 1.3 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 EFA84374.1 - 0.05 13.2 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW ANAPC5 PF12862.7 EFA84374.1 - 0.08 13.0 0.0 0.36 10.9 0.0 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 Methyltransf_8 PF05148.15 EFA84374.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase TPR_MLP1_2 PF07926.12 EFA84375.1 - 3.3e-28 98.3 18.5 3.3e-28 98.3 18.5 8.3 5 2 4 9 9 9 1 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 EFA84375.1 - 0.0005 20.3 7.4 0.0005 20.3 7.4 8.4 3 1 5 8 8 8 1 JNK_SAPK-associated protein-1 zf-RAG1 PF10426.9 EFA84375.1 - 0.027 14.6 0.2 0.065 13.4 0.2 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain DUF2721 PF11026.8 EFA84375.1 - 0.93 9.4 0.0 0.93 9.4 0.0 3.5 5 0 0 5 5 5 0 Protein of unknown function (DUF2721) Glyco_hydro_67C PF07477.12 EFA84375.1 - 1.9 8.0 18.1 0.19 11.2 0.6 3.4 3 0 0 3 3 3 0 Glycosyl hydrolase family 67 C-terminus ATG16 PF08614.11 EFA84376.1 - 0.00095 19.4 14.7 0.00095 19.4 14.7 6.0 1 1 6 7 7 7 1 Autophagy protein 16 (ATG16) DUF5063 PF16702.5 EFA84376.1 - 0.0041 17.5 1.3 0.0041 17.5 1.3 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5063) KASH_CCD PF14662.6 EFA84376.1 - 0.093 12.6 97.4 0.075 12.8 15.2 6.4 1 1 4 6 6 6 0 Coiled-coil region of CCDC155 or KASH DUF2935 PF11155.8 EFA84376.1 - 0.57 10.5 28.5 1.3 9.4 3.1 5.5 1 1 1 4 4 4 0 Domain of unknown function (DUF2935) HMGL-like PF00682.19 EFA84376.1 - 0.82 9.2 4.1 0.66 9.5 0.2 2.5 3 0 0 3 3 3 0 HMGL-like HycI PF01750.18 EFA84376.1 - 1.1 9.0 6.4 0.17 11.7 0.6 2.6 3 0 0 3 3 3 0 Hydrogenase maturation protease ADIP PF11559.8 EFA84376.1 - 7.8 6.6 87.1 0.079 13.0 11.2 6.7 3 1 4 7 7 7 0 Afadin- and alpha -actinin-Binding HAUS5 PF14817.6 EFA84377.1 - 0.037 12.8 2.0 0.042 12.6 2.0 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 PAP_RNA-bind PF04926.15 EFA84377.1 - 0.13 11.9 2.2 0.27 10.9 2.2 1.5 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain DUF3453 PF11935.8 EFA84378.1 - 2.3e-18 66.7 0.3 2.3e-18 66.7 0.3 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) Symplekin_C PF12295.8 EFA84378.1 - 0.00032 20.8 1.4 0.0021 18.2 0.0 3.0 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal Activator_LAG-3 PF11498.8 EFA84378.1 - 0.0006 18.9 29.1 0.0013 17.8 29.1 1.5 1 0 0 1 1 1 1 Transcriptional activator LAG-3 ALMT PF11744.8 EFA84378.1 - 0.057 12.2 4.5 0.12 11.2 4.5 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.6 EFA84378.1 - 3.1 7.1 6.2 6.7 6.0 6.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BORG_CEP PF14957.6 EFA84378.1 - 3.7 8.7 14.9 1.3 10.2 5.2 3.0 2 0 0 2 2 2 0 Cdc42 effector PP2C PF00481.21 EFA84379.1 - 1.3e-62 211.8 0.0 1.3e-62 211.8 0.0 1.7 2 0 0 2 2 2 1 Protein phosphatase 2C Macoilin PF09726.9 EFA84379.1 - 0.16 10.5 18.6 0.2 10.2 18.6 1.1 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 EFA84379.1 - 0.75 9.7 19.5 1 9.2 19.5 1.2 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 EFA84379.1 - 1.4 7.6 7.7 1.6 7.3 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1387 PF07139.11 EFA84379.1 - 1.5 8.5 21.5 2.2 7.9 21.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PCI PF01399.27 EFA84380.1 - 4.4e-16 59.3 1.4 5.8e-16 58.9 0.2 1.9 2 0 0 2 2 2 1 PCI domain RRM_1 PF00076.22 EFA84381.1 - 1.2e-09 37.9 0.1 3.8e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA84381.1 - 0.08 12.5 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thioredoxin_2 PF13098.6 EFA84384.1 - 0.024 15.1 0.0 0.03 14.8 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin PF00085.20 EFA84384.1 - 0.054 13.5 0.0 0.063 13.3 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin RNA_pol_Rpb5_N PF03871.14 EFA84384.1 - 0.08 13.5 0.0 0.091 13.4 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain RRM_1 PF00076.22 EFA84385.1 - 1.4e-13 50.4 0.0 2.2e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EFA84385.1 - 5.4e-05 23.1 5.6 0.00013 21.9 5.6 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EFA84385.1 - 0.0087 16.0 1.0 0.022 14.7 1.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EFA84385.1 - 0.055 13.2 6.2 0.11 12.2 6.2 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Nup35_RRM_2 PF14605.6 EFA84385.1 - 0.068 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFA84385.1 - 0.082 13.0 0.0 0.55 10.4 0.0 2.1 1 1 1 2 2 2 0 RNA recognition motif zf-CCHC_2 PF13696.6 EFA84385.1 - 0.098 12.5 5.7 0.16 11.9 5.7 1.3 1 0 0 1 1 1 0 Zinc knuckle DbpA PF03880.15 EFA84385.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 DbpA RNA binding domain Cpn60_TCP1 PF00118.24 EFA84386.1 - 9.2e-105 351.1 2.0 1.1e-104 350.8 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pcc1 PF09341.10 EFA84386.1 - 0.056 13.6 0.0 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Transcription factor Pcc1 Peptidase_M41 PF01434.18 EFA84387.1 - 1.4e-66 224.0 0.1 3.3e-66 222.8 0.1 1.7 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFA84387.1 - 1.8e-44 151.3 0.0 5.1e-44 149.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFA84387.1 - 6.9e-14 51.4 0.0 1.7e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EFA84387.1 - 0.0002 21.7 0.4 0.0002 21.7 0.4 3.7 3 1 1 4 4 2 1 FtsH Extracellular AAA_5 PF07728.14 EFA84387.1 - 0.00068 19.7 0.0 0.0028 17.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EFA84387.1 - 0.0051 17.2 0.0 0.013 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFA84387.1 - 0.0052 16.5 0.0 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFA84387.1 - 0.02 15.3 0.4 0.86 10.0 0.1 2.9 2 1 1 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 EFA84387.1 - 0.025 14.9 1.5 0.38 11.0 0.1 2.9 2 1 1 3 3 3 0 AAA domain AAA_2 PF07724.14 EFA84387.1 - 0.06 13.5 0.0 0.06 13.5 0.0 2.4 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EFA84387.1 - 0.094 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFA84387.1 - 0.12 11.8 0.1 0.25 10.7 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Med21 PF11221.8 EFA84387.1 - 0.6 10.4 5.5 4.6 7.5 2.8 2.8 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Presenilin PF01080.17 EFA84387.1 - 0.63 8.7 13.7 1.3 7.7 13.7 1.4 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 EFA84387.1 - 1.3 7.8 5.5 2.3 7.0 5.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF5308 PF17233.2 EFA84387.1 - 2.3 8.4 10.7 0.046 14.0 1.8 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5308) DUF4484 PF14831.6 EFA84387.1 - 2.9 7.9 10.7 5.7 6.9 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) AAA_18 PF13238.6 EFA84387.1 - 7.3 7.2 6.8 6.5 7.3 0.0 3.8 4 1 1 5 5 2 0 AAA domain NOA36 PF06524.12 EFA84387.1 - 9 5.5 11.1 15 4.8 11.1 1.3 1 0 0 1 1 1 0 NOA36 protein Pkinase PF00069.25 EFA84388.1 - 1.3e-73 247.6 0.0 2e-73 247.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84388.1 - 4.7e-54 183.4 0.0 9.4e-54 182.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase TIG PF01833.24 EFA84388.1 - 4.5e-16 58.7 30.3 7.4e-07 29.2 2.3 5.0 5 0 0 5 5 4 3 IPT/TIG domain Pkinase_fungal PF17667.1 EFA84388.1 - 3.7e-05 22.7 0.0 8.1e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase SKG6 PF08693.10 EFA84388.1 - 0.0011 18.3 0.6 0.0024 17.2 0.6 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain LRR_8 PF13855.6 EFA84388.1 - 0.0021 17.8 0.9 0.0021 17.8 0.9 2.9 3 0 0 3 3 3 1 Leucine rich repeat Mid2 PF04478.12 EFA84388.1 - 0.012 15.5 0.1 0.026 14.3 0.1 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor YrbL-PhoP_reg PF10707.9 EFA84388.1 - 0.029 13.9 0.2 0.06 12.9 0.2 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Fib_alpha PF08702.10 EFA84388.1 - 0.053 13.7 0.8 0.14 12.4 0.8 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Kinase-like PF14531.6 EFA84388.1 - 0.053 12.8 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFA84388.1 - 0.22 11.4 0.0 3.7 7.4 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family SlyX PF04102.12 EFA84388.1 - 0.29 11.8 2.2 0.58 10.8 1.3 1.9 2 0 0 2 2 2 0 SlyX SAM_1 PF00536.30 EFA84390.1 - 7e-11 42.4 0.2 1.1e-10 41.7 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA84390.1 - 1.2e-09 38.1 0.1 2.2e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SRP-alpha_N PF04086.13 EFA84390.1 - 0.0056 16.6 3.3 0.0071 16.3 3.3 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal DASH_Spc19 PF08287.11 EFA84390.1 - 0.22 11.4 9.0 0.17 11.8 6.3 2.0 2 0 0 2 2 2 0 Spc19 EI24 PF07264.11 EFA84391.1 - 1.5e-24 87.2 23.9 2.1e-24 86.8 23.9 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Menin PF05053.13 EFA84391.1 - 0.043 12.2 0.2 0.057 11.8 0.2 1.1 1 0 0 1 1 1 0 Menin RRM_5 PF13893.6 EFA84392.1 - 7.1e-37 125.8 0.1 2.9e-26 91.5 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EFA84392.1 - 2.6e-29 100.8 0.5 4.5e-09 36.0 0.0 4.3 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 EFA84392.1 - 4.1e-16 58.9 0.0 9.6e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 RRM-like domain RRM_7 PF16367.5 EFA84392.1 - 0.028 14.5 0.0 11 6.2 0.0 2.8 2 0 0 2 2 2 0 RNA recognition motif zf-C2H2_4 PF13894.6 EFA84393.1 - 1.9 9.6 4.6 2.4 9.2 0.3 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger Diphthamide_syn PF01866.17 EFA84394.1 - 5.4e-99 331.5 0.3 2.4e-68 230.8 0.0 2.2 1 1 1 2 2 2 2 Putative diphthamide synthesis protein Pro_isomerase PF00160.21 EFA84395.1 - 7.6e-52 175.8 0.0 1.5e-51 174.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 EFA84395.1 - 7.4e-06 26.0 0.2 2.2e-05 24.5 0.2 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 EFA84395.1 - 0.0033 17.6 1.2 0.042 14.0 0.0 2.9 3 0 0 3 3 3 1 U-box domain EXOSC1 PF10447.9 EFA84395.1 - 0.84 10.3 3.1 9.3 6.9 0.8 2.3 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 Annexin PF00191.20 EFA84396.1 - 1.2e-72 239.9 5.8 9.1e-21 73.7 0.0 4.1 4 0 0 4 4 4 4 Annexin DUF2312 PF10073.9 EFA84396.1 - 0.025 14.2 0.0 0.93 9.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Glyco_hydro_77 PF02446.17 EFA84397.1 - 2e-159 531.4 2.7 2.7e-159 530.9 2.7 1.1 1 0 0 1 1 1 1 4-alpha-glucanotransferase CBM_20 PF00686.19 EFA84397.1 - 3.3e-36 123.1 2.3 4.6e-18 64.9 0.1 3.7 2 1 1 3 3 3 3 Starch binding domain RT_RNaseH PF17917.1 EFA84397.1 - 6.3e-15 55.3 0.2 1.6e-14 54.0 0.2 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA84397.1 - 1.5e-07 31.4 0.1 4.5e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Imm53 PF15580.6 EFA84397.1 - 0.78 9.5 3.4 21 4.9 0.0 3.4 3 0 0 3 3 3 0 Immunity protein 53 SARAF PF06682.12 EFA84398.1 - 1.9e-69 234.9 8.2 3.1e-69 234.2 8.2 1.3 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Spo7 PF03907.13 EFA84398.1 - 0.017 14.6 1.2 0.021 14.3 0.2 1.5 2 0 0 2 2 2 0 Spo7-like protein DUF4834 PF16118.5 EFA84398.1 - 0.64 11.0 0.1 0.64 11.0 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) FeoB_associated PF12669.7 EFA84398.1 - 0.79 10.2 5.5 14 6.2 0.0 2.7 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein FtsH_ext PF06480.15 EFA84398.1 - 1.3 9.4 4.2 4.4 7.7 0.0 3.0 3 0 0 3 3 3 0 FtsH Extracellular Band_7 PF01145.25 EFA84399.1 - 3.3e-24 85.9 1.1 3.3e-24 85.9 1.1 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EFA84399.1 - 0.0023 17.0 1.7 0.0045 16.1 1.7 1.4 1 1 1 2 2 2 1 SigmaW regulon antibacterial Peptidase_S66 PF02016.15 EFA84399.1 - 0.047 13.8 0.0 0.084 13.0 0.0 1.5 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain 60KD_IMP PF02096.20 EFA84401.1 - 1.6e-23 83.4 4.7 1.6e-23 83.4 4.7 2.0 2 0 0 2 2 2 1 60Kd inner membrane protein CODH_A_N PF18537.1 EFA84401.1 - 0.15 12.1 0.5 0.86 9.7 0.0 2.2 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain Med9 PF07544.13 EFA84401.1 - 0.15 12.1 4.7 1.1 9.4 0.2 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 BST2 PF16716.5 EFA84401.1 - 3.4 8.3 8.8 0.36 11.4 3.0 2.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Thy1 PF02511.15 EFA84402.1 - 0.14 11.9 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 Thymidylate synthase complementing protein SUIM_assoc PF16619.5 EFA84403.1 - 0.19 11.8 5.7 0.42 10.7 5.7 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Mucin PF01456.17 EFA84404.1 - 0.57 10.2 23.3 1.4 8.9 23.3 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein ALMT PF11744.8 EFA84405.1 - 2.3e-27 96.0 9.0 2.3e-27 96.0 9.0 2.2 3 0 0 3 3 3 1 Aluminium activated malate transporter FUSC PF04632.12 EFA84405.1 - 1.7e-16 60.0 0.1 1.7e-16 60.0 0.1 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein family FUSC_2 PF13515.6 EFA84405.1 - 1.8e-16 60.4 11.3 1.8e-16 60.4 11.3 3.4 2 1 0 2 2 2 1 Fusaric acid resistance protein-like GatB_N PF02934.15 EFA84406.1 - 2.2e-105 352.0 0.1 3e-105 351.5 0.1 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EFA84406.1 - 1.6e-42 144.9 0.3 3.2e-42 143.9 0.3 1.5 1 0 0 1 1 1 1 GatB domain LMBR1 PF04791.16 EFA84407.1 - 1.2e-86 291.7 20.1 1.5e-75 255.1 4.3 2.7 2 1 1 3 3 3 2 LMBR1-like membrane protein Ctr PF04145.15 EFA84408.1 - 0.15 12.7 7.1 1.2 9.8 0.2 3.3 3 0 0 3 3 3 0 Ctr copper transporter family Menin PF05053.13 EFA84408.1 - 0.29 9.4 20.1 0.0071 14.8 3.6 2.8 3 0 0 3 3 3 0 Menin CPSF100_C PF13299.6 EFA84408.1 - 5.4 7.2 11.5 1.2 9.3 1.9 2.9 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 EFA84409.1 - 1e-53 182.8 12.6 1.4e-53 182.3 12.6 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Alg14 PF08660.11 EFA84409.1 - 0.033 14.1 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like UCH_1 PF13423.6 EFA84410.1 - 1.1e-73 248.6 23.6 1.1e-73 248.6 23.6 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EFA84410.1 - 1.7e-18 67.7 0.0 4.3e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EFA84410.1 - 3.5e-09 36.6 17.9 3.5e-09 36.6 17.9 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF2807 PF10988.8 EFA84410.1 - 0.015 15.1 0.1 0.032 14.0 0.1 1.5 1 0 0 1 1 1 0 Putative auto-transporter adhesin, head GIN domain Spt20 PF12090.8 EFA84410.1 - 0.31 10.6 35.9 0.65 9.6 6.7 3.6 3 0 0 3 3 3 0 Spt20 family RecA PF00154.21 EFA84411.1 - 1.2e-132 441.3 1.0 1.5e-132 440.9 1.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.11 EFA84411.1 - 1.3e-13 50.9 0.1 4.4e-13 49.1 0.1 1.8 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 EFA84411.1 - 1.4e-09 37.7 0.7 3.9e-07 29.7 0.7 3.0 1 1 0 1 1 1 1 KaiC ATPase_2 PF01637.18 EFA84411.1 - 0.0001 22.3 1.3 0.0012 18.9 0.0 2.9 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA PF00004.29 EFA84411.1 - 0.00013 22.4 0.6 0.0042 17.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFA84411.1 - 0.00061 19.6 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFA84411.1 - 0.0018 18.5 0.1 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain CobU PF02283.16 EFA84411.1 - 0.0046 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_25 PF13481.6 EFA84411.1 - 0.01 15.4 0.2 0.041 13.4 0.2 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA84411.1 - 0.013 16.1 1.6 0.029 14.9 0.0 2.4 3 0 0 3 3 3 0 ABC transporter AAA_35 PF14516.6 EFA84411.1 - 0.019 13.8 0.0 0.034 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.6 EFA84411.1 - 0.03 14.9 0.1 0.22 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EFA84411.1 - 0.034 14.2 0.9 0.21 11.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain TK PF00265.18 EFA84411.1 - 0.047 13.6 0.1 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Thymidine kinase AAA_16 PF13191.6 EFA84411.1 - 0.048 14.0 0.2 0.1 12.9 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain PBP1_TM PF14812.6 EFA84411.1 - 2.4 8.6 10.2 9 6.7 0.9 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Phosphoesterase PF04185.14 EFA84412.1 - 2.1e-93 313.4 1.3 3e-93 312.9 1.3 1.2 1 0 0 1 1 1 1 Phosphoesterase family Defensin_2 PF01097.18 EFA84412.1 - 4.8 7.2 7.8 0.73 9.8 2.2 2.5 2 0 0 2 2 2 0 Arthropod defensin WD40 PF00400.32 EFA84413.1 - 6.2e-26 90.1 3.6 1.5e-07 32.0 0.1 7.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA84413.1 - 1.4e-21 76.6 0.8 0.00063 20.0 0.0 6.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFA84413.1 - 8.6e-10 38.3 1.2 0.00023 21.0 0.1 4.0 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EFA84413.1 - 0.0004 19.8 0.0 0.093 12.0 0.0 2.9 3 0 0 3 3 3 1 WD40-like domain Utp14 PF04615.13 EFA84413.1 - 2 6.9 26.9 2.5 6.5 26.9 1.1 1 0 0 1 1 1 0 Utp14 protein SPX PF03105.19 EFA84413.1 - 2.7 7.8 43.5 3.8 7.3 43.5 1.2 1 0 0 1 1 1 0 SPX domain FSA_C PF10479.9 EFA84413.1 - 3 5.9 24.5 4 5.5 24.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Hamartin PF04388.12 EFA84413.1 - 4.9 5.7 27.8 6.3 5.3 27.8 1.1 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 EFA84413.1 - 6.8 5.2 23.1 11 4.5 23.1 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 EFA84413.1 - 10 5.2 40.3 17 4.4 40.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein AUX_IAA PF02309.16 EFA84416.1 - 0.057 13.3 0.1 0.057 13.3 0.1 3.2 3 0 0 3 3 3 0 AUX/IAA family F-box PF00646.33 EFA84417.1 - 1.3e-08 34.5 1.1 3.2e-08 33.2 0.1 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFA84417.1 - 4.5e-07 29.7 0.1 4.5e-07 29.7 0.1 1.9 2 0 0 2 2 2 1 F-box-like BTK PF00779.19 EFA84417.1 - 0.00038 20.2 1.1 0.00075 19.3 1.1 1.5 1 0 0 1 1 1 1 BTK motif Elongin_A PF06881.11 EFA84417.1 - 0.11 13.0 1.9 0.27 11.8 1.9 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RNA_polI_A34 PF08208.11 EFA84418.1 - 3e-18 66.7 32.3 3e-18 66.7 32.3 3.5 1 1 3 4 4 4 1 DNA-directed RNA polymerase I subunit RPA34.5 UPF1_Zn_bind PF09416.10 EFA84419.1 - 1.1e-66 223.5 5.0 1.1e-66 223.5 5.0 2.4 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EFA84419.1 - 1.1e-61 207.9 0.4 2.3e-61 206.9 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.6 EFA84419.1 - 1.7e-45 155.9 12.8 9.5e-27 94.4 0.0 3.4 2 1 1 3 3 3 2 AAA domain DUF5599 PF18141.1 EFA84419.1 - 1.4e-26 92.5 0.0 4.1e-26 91.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EFA84419.1 - 2.9e-12 46.7 0.0 4.5e-11 42.8 0.0 2.5 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.6 EFA84419.1 - 5.6e-12 46.2 0.2 4.2e-11 43.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EFA84419.1 - 0.0003 20.6 0.2 0.6 9.8 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 EFA84419.1 - 0.0023 17.7 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFA84419.1 - 0.0037 17.3 2.5 0.0044 17.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PIF1 PF05970.14 EFA84419.1 - 0.0069 15.6 0.0 0.66 9.1 0.0 2.3 2 0 0 2 2 2 1 PIF1-like helicase DUF2075 PF09848.9 EFA84419.1 - 0.0087 15.3 0.0 0.0087 15.3 0.0 3.6 4 1 0 4 4 3 1 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 EFA84419.1 - 0.0098 15.9 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain RNA_helicase PF00910.22 EFA84419.1 - 0.042 14.3 0.0 0.21 12.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.14 EFA84419.1 - 0.077 13.0 0.0 0.45 10.5 0.0 2.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 EFA84419.1 - 0.087 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 EFA84419.1 - 0.12 12.7 0.0 0.59 10.4 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFA84419.1 - 0.13 12.6 0.1 0.42 11.0 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EFA84419.1 - 0.14 11.5 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 KaiC Helicase_RecD PF05127.14 EFA84419.1 - 0.15 11.9 3.0 0.22 11.3 0.0 2.4 2 0 0 2 2 2 0 Helicase TFIIA PF03153.13 EFA84419.1 - 3.9 7.4 28.3 0.034 14.1 18.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PGP_phosphatase PF09419.10 EFA84421.1 - 1.5e-44 151.6 0.0 1.9e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EFA84421.1 - 9.6e-06 25.6 0.0 1.5e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFA84421.1 - 0.01 16.2 0.0 1.7 8.9 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase PCI PF01399.27 EFA84422.1 - 1.3e-16 61.0 0.3 8.2e-16 58.4 0.1 2.2 2 0 0 2 2 2 1 PCI domain CBM49 PF09478.10 EFA84423.1 - 5.5e-09 36.2 1.2 3.2e-08 33.8 0.0 3.1 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 Asp PF00026.23 EFA84424.1 - 4.5e-20 72.3 0.0 7.5e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EFA84424.1 - 8.7e-16 58.1 0.0 2.1e-15 56.9 0.0 1.6 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EFA84424.1 - 3.8e-10 40.3 5.0 1.4e-09 38.4 0.1 2.8 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal CBM49 PF09478.10 EFA84424.1 - 9.9e-05 22.6 1.2 0.41 11.0 0.2 2.6 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 Response_reg PF00072.24 EFA84425.1 - 7.4e-20 71.2 0.0 1.8e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Androgen_recep PF02166.16 EFA84425.1 - 0.11 11.4 11.2 0.22 10.3 11.2 1.5 1 0 0 1 1 1 0 Androgen receptor CobT PF06213.12 EFA84425.1 - 1.6 8.0 8.2 5.2 6.4 8.2 1.8 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4175 PF13779.6 EFA84425.1 - 1.8 6.3 10.3 3.1 5.6 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF3439 PF11921.8 EFA84425.1 - 7.3 6.6 42.1 0.026 14.5 8.1 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF3439) C1_1 PF00130.22 EFA84426.1 - 0.0011 18.8 4.4 0.0022 17.9 4.4 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EFA84426.1 - 0.0043 16.9 2.7 0.009 15.9 2.7 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFA84426.1 - 0.018 14.6 0.7 0.036 13.6 0.7 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 EFA84426.1 - 0.027 14.4 0.8 0.061 13.3 0.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 FixO PF02433.15 EFA84426.1 - 1.1 8.7 7.4 0.56 9.6 4.0 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase, mono-heme subunit/FixO DNase_II PF03265.15 EFA84428.1 - 1.4e-97 326.9 0.8 1.6e-97 326.7 0.8 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Ral PF11058.8 EFA84428.1 - 0.077 12.6 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Antirestriction protein Ral SapB_2 PF03489.17 EFA84429.1 - 9.6e-12 44.8 1.7 9.6e-12 44.8 1.7 2.0 2 0 0 2 2 2 1 Saposin-like type B, region 2 SapB_1 PF05184.15 EFA84429.1 - 3.5e-09 36.5 3.1 8.8e-09 35.2 0.4 2.5 2 0 0 2 2 2 1 Saposin-like type B, region 1 LepB_N PF18640.1 EFA84429.1 - 0.032 13.8 0.1 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 LepB N-terminal domain eIF2_C PF09173.11 EFA84430.1 - 9.2e-35 118.8 0.7 2.6e-34 117.3 0.2 2.1 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EFA84430.1 - 5.2e-22 78.3 1.2 5.8e-21 74.9 1.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFA84430.1 - 9.1e-12 45.2 0.3 3.4e-11 43.4 0.3 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 EFA84430.1 - 0.015 15.3 0.1 0.036 14.1 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EFA84430.1 - 0.019 14.9 1.6 0.09 12.7 0.1 2.4 3 0 0 3 3 3 0 RsgA GTPase MMR_HSR1 PF01926.23 EFA84430.1 - 0.043 13.9 0.0 0.09 12.9 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA84430.1 - 0.39 10.5 1.3 0.97 9.2 0.0 2.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain Esterase_phd PF10503.9 EFA84431.1 - 4.5e-09 36.1 1.6 1.5e-05 24.6 0.1 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase TPR_17 PF13431.6 EFA84432.1 - 8.3e-65 210.6 11.2 2.9e-12 46.1 0.1 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84432.1 - 2.8e-14 52.5 16.1 0.25 11.1 0.1 6.4 6 0 0 6 6 6 6 TPR repeat Anth_Ig PF05587.13 EFA84432.1 - 3.4e-05 24.1 4.6 9.4 6.6 0.0 5.1 5 0 0 5 5 5 2 Anthrax receptor extracellular domain Lyx_isomer PF07385.12 EFA84432.1 - 0.0013 18.0 0.4 39 3.4 0.0 4.8 1 1 4 5 5 5 0 D-lyxose isomerase DUF3255 PF11631.8 EFA84432.1 - 0.0036 17.2 6.1 8.4 6.3 0.1 5.0 1 1 4 5 5 5 1 Protein of unknown function (DUF3255) NleF_casp_inhib PF16809.5 EFA84432.1 - 0.038 13.9 5.1 40 4.1 0.1 4.9 2 2 2 5 5 5 0 NleF caspase inhibitor TPR_19 PF14559.6 EFA84432.1 - 0.16 12.5 0.9 7.9 7.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat YjzC PF14168.6 EFA84432.1 - 0.18 12.2 0.0 31 5.0 0.0 3.9 3 1 2 5 5 5 0 YjzC-like protein gerPA PF10676.9 EFA84432.1 - 0.19 12.0 16.3 1.4 9.2 0.5 4.9 5 0 0 5 5 5 0 Spore germination protein gerPA/gerPF Epiglycanin_TR PF05647.11 EFA84432.1 - 6.3 6.8 18.5 22 5.1 0.3 5.0 4 1 0 4 4 4 0 Tandem-repeating region of mucin, epiglycanin-like DDE_Tnp_4 PF13359.6 EFA84433.1 - 1.5e-19 70.3 0.4 3.7e-19 69.0 0.1 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.6 EFA84433.1 - 5e-14 51.8 0.0 9.5e-14 50.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA84433.1 - 0.00014 21.6 0.1 0.00014 21.6 0.1 2.5 2 1 0 2 2 1 1 Transposase DDE domain Ureide_permease PF07168.11 EFA84433.1 - 0.069 11.9 0.6 0.12 11.1 0.6 1.4 1 0 0 1 1 1 0 Ureide permease Zip PF02535.22 EFA84433.1 - 0.13 11.5 0.5 0.23 10.7 0.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 EFA84433.1 - 0.17 9.9 16.1 0.28 9.2 16.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EFA84433.1 - 0.28 11.6 8.8 0.77 10.2 8.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Serinc PF03348.15 EFA84433.1 - 0.44 9.4 1.9 0.64 8.9 1.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Cytomega_UL84 PF06284.11 EFA84433.1 - 0.52 8.7 2.8 0.77 8.1 2.8 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Pox_Ag35 PF03286.14 EFA84433.1 - 2.7 7.7 21.2 0.055 13.3 13.7 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein RNA_pol_Rpc4 PF05132.14 EFA84433.1 - 4.9 7.6 9.6 0.24 11.8 2.4 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 MRNIP PF15749.5 EFA84433.1 - 5.1 7.9 18.1 3.7 8.3 0.4 3.1 3 1 0 3 3 2 0 MRN-interacting protein Vfa1 PF08432.10 EFA84433.1 - 5.9 7.2 29.8 0.38 11.1 13.1 3.2 2 1 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CPSF100_C PF13299.6 EFA84433.1 - 7.4 6.7 10.7 5.6 7.1 4.7 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4611 PF15387.6 EFA84433.1 - 8.4 6.7 17.2 21 5.4 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) DUF2076 PF09849.9 EFA84433.1 - 9.1 6.2 8.7 1.2 9.1 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) VPS9 PF02204.18 EFA84434.1 - 1.8e-11 44.2 0.1 1.4e-10 41.3 0.1 2.5 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain LisH PF08513.11 EFA84437.1 - 0.079 12.9 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 LisH Dehydrin PF00257.19 EFA84437.1 - 0.28 11.7 10.5 2.5 8.7 1.3 3.5 3 0 0 3 3 3 0 Dehydrin Hamartin PF04388.12 EFA84437.1 - 1.2 7.8 51.9 1.7 7.2 13.5 2.2 2 0 0 2 2 2 0 Hamartin protein CBM49 PF09478.10 EFA84438.1 - 2.8e-17 62.8 1.2 4.2e-17 62.2 1.2 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 SH3_10 PF17902.1 EFA84438.1 - 0.037 14.1 0.1 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 SH3 domain AP3B1_C PF14796.6 EFA84438.1 - 0.043 14.1 0.0 0.057 13.7 0.0 1.3 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal CamS PF07537.11 EFA84438.1 - 0.054 12.6 0.0 0.074 12.2 0.0 1.1 1 0 0 1 1 1 0 CamS sex pheromone cAM373 precursor Peptidase_M24 PF00557.24 EFA84439.1 - 5.5e-21 75.2 0.0 9.8e-21 74.4 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 EFP_N PF08207.12 EFA84440.1 - 1.1e-10 41.4 0.3 4e-10 39.6 0.1 2.1 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain Peptidase_C54 PF03416.19 EFA84441.1 - 4.2e-89 298.6 0.2 4.2e-89 298.6 0.2 2.3 2 1 0 2 2 2 1 Peptidase family C54 Peripla_BP_2 PF01497.18 EFA84441.1 - 0.019 14.6 1.8 0.047 13.2 1.8 1.7 1 0 0 1 1 1 0 Periplasmic binding protein SPX PF03105.19 EFA84441.1 - 0.23 11.4 25.9 0.14 12.0 22.4 2.1 2 0 0 2 2 2 0 SPX domain EPL1 PF10513.9 EFA84441.1 - 1.8 8.9 29.4 2.6 8.4 10.8 2.6 2 0 0 2 2 2 0 Enhancer of polycomb-like ICMT PF04140.14 EFA84442.1 - 2.5e-30 104.7 0.6 4.2e-30 104.0 0.2 1.6 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFA84442.1 - 2.2e-07 31.2 0.9 2.2e-07 31.2 0.9 2.4 2 1 1 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 EFA84442.1 - 0.0014 18.2 0.5 0.0028 17.2 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) IKI3 PF04762.12 EFA84443.1 - 5.5e-250 832.2 1.4 5.5e-250 832.2 1.4 1.7 2 0 0 2 2 2 1 IKI3 family Clathrin PF00637.20 EFA84443.1 - 0.02 14.8 4.1 1 9.3 1.3 3.5 1 1 1 2 2 2 0 Region in Clathrin and VPS APG12 PF04110.13 EFA84443.1 - 0.033 14.6 0.3 0.51 10.8 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin-like autophagy protein Apg12 ANAPC4_WD40 PF12894.7 EFA84443.1 - 0.048 14.0 0.3 26 5.2 0.0 4.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SH3_9 PF14604.6 EFA84444.1 - 5.3e-13 48.6 0.2 9.6e-13 47.8 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA84444.1 - 2.6e-12 46.1 0.1 5.2e-12 45.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA84444.1 - 2e-10 40.2 0.1 4e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain U1snRNP70_N PF12220.8 EFA84444.1 - 0.0048 17.5 2.3 0.0048 17.5 2.3 4.6 3 1 1 5 5 5 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DivIC PF04977.15 EFA84444.1 - 0.013 15.3 8.5 0.013 15.3 8.5 3.9 4 0 0 4 4 4 0 Septum formation initiator Nucleoporin_FG2 PF15967.5 EFA84444.1 - 3.5 6.1 6.9 6.4 5.2 6.9 1.4 1 0 0 1 1 1 0 Nucleoporin FG repeated region Peptidase_S28 PF05577.12 EFA84445.1 - 6.8e-123 410.7 2.7 2.9e-122 408.6 2.7 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 RWD PF05773.22 EFA84445.1 - 3.2e-20 72.6 1.1 9.3e-20 71.1 0.5 2.2 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EFA84445.1 - 2.1e-07 31.3 1.9 6.4e-07 29.8 1.9 1.9 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 DUF1741 PF08427.10 EFA84446.1 - 9e-39 133.5 12.2 1.4e-37 129.6 12.2 2.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1741) ORC6 PF05460.13 EFA84446.1 - 6.7 5.9 20.3 15 4.8 20.3 1.5 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ank_5 PF13857.6 EFA84447.1 - 4.6e-14 52.3 0.2 4.1e-05 23.8 0.0 4.5 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA84447.1 - 9.4e-12 45.2 0.9 0.00021 21.8 0.0 3.9 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84447.1 - 2e-11 44.3 2.5 1.3e-07 32.1 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84447.1 - 8.8e-07 28.8 0.2 4.1 8.3 0.0 5.1 6 0 0 6 6 6 2 Ankyrin repeat DUF5049 PF16468.5 EFA84447.1 - 9.1e-05 22.3 0.1 1.2 9.1 0.0 4.4 3 1 1 4 4 4 1 Domain of unknown function (DUF5049) Helicase_RecD PF05127.14 EFA84447.1 - 0.029 14.2 0.1 0.039 13.8 0.1 1.4 1 0 0 1 1 1 0 Helicase DUF3447 PF11929.8 EFA84447.1 - 0.14 12.2 3.4 0.34 10.9 0.4 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA84448.1 - 3.9e-10 40.2 0.2 0.1 13.2 0.1 4.3 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84448.1 - 4.2e-05 24.0 0.1 4.6 7.9 0.0 5.0 5 1 0 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84448.1 - 0.00013 22.1 0.0 1.2e+02 3.8 0.0 6.1 5 1 1 6 6 6 0 Ankyrin repeat Ank_5 PF13857.6 EFA84448.1 - 0.00029 21.1 0.0 21 5.6 0.0 4.9 3 2 3 6 6 6 1 Ankyrin repeats (many copies) HTH_15 PF12324.8 EFA84448.1 - 0.01 15.8 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase HTH_6 PF01418.17 EFA84448.1 - 0.035 14.1 0.4 3.2 7.8 0.1 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain, rpiR family TPR_17 PF13431.6 EFA84449.1 - 5.6e-69 223.7 21.2 6.6e-12 44.9 0.1 8.2 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84449.1 - 2.8e-07 30.1 26.5 0.078 12.7 0.2 7.6 8 0 0 8 8 8 4 TPR repeat Anth_Ig PF05587.13 EFA84449.1 - 0.00019 21.7 13.9 2.7 8.4 0.1 6.6 7 0 0 7 7 7 3 Anthrax receptor extracellular domain MIT_C PF16565.5 EFA84449.1 - 0.00026 21.0 1.5 0.23 11.5 0.1 3.5 1 1 2 3 3 3 2 Phospholipase D-like domain at C-terminus of MIT NleF_casp_inhib PF16809.5 EFA84449.1 - 0.012 15.5 5.9 20 5.1 0.0 5.6 2 2 3 7 7 7 0 NleF caspase inhibitor RFX5_N PF18326.1 EFA84449.1 - 0.41 10.4 4.8 14 5.6 0.1 3.4 4 0 0 4 4 4 0 RFX5 N-terminal domain TPR_17 PF13431.6 EFA84450.1 - 3.1e-88 284.0 8.5 1.2e-11 44.1 0.1 8.3 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84450.1 - 6.3e-12 45.0 17.3 0.1 12.3 0.2 8.1 8 0 0 8 8 8 5 TPR repeat Anth_Ig PF05587.13 EFA84450.1 - 2.3e-07 31.0 7.6 13 6.1 0.1 7.2 7 0 0 7 7 7 2 Anthrax receptor extracellular domain P22_CoatProtein PF11651.8 EFA84450.1 - 0.00045 18.9 1.0 2.6 6.5 0.1 3.9 2 2 2 4 4 4 2 P22 coat protein - gene protein 5 NleF_casp_inhib PF16809.5 EFA84450.1 - 0.00084 19.3 7.4 34 4.3 0.0 6.7 2 1 4 7 7 7 0 NleF caspase inhibitor DUF1344 PF07076.11 EFA84450.1 - 0.0082 16.0 6.3 23 5.0 0.1 5.9 6 0 0 6 6 6 0 Protein of unknown function (DUF1344) Tudor_RapA PF18337.1 EFA84450.1 - 0.063 13.5 1.8 58 4.0 0.0 4.6 6 0 0 6 6 6 0 RapA N-terminal Tudor like domain Cadherin_3 PF16184.5 EFA84450.1 - 0.098 12.7 2.4 1.6 8.7 0.1 2.8 2 1 0 2 2 2 0 Cadherin-like zf-C2H2_4 PF13894.6 EFA84450.1 - 0.19 12.7 5.6 0.54 11.2 3.9 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFA84450.1 - 0.27 11.8 6.7 0.81 10.3 4.3 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type LMP PF04778.12 EFA84450.1 - 0.47 10.4 7.8 4.5 7.2 2.4 3.4 2 1 0 2 2 2 0 LMP repeated region SR-25 PF10500.9 EFA84450.1 - 0.56 9.8 8.2 0.97 9.0 8.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-H2C2_2 PF13465.6 EFA84450.1 - 5.2 7.7 8.1 18 6.0 1.3 2.9 2 0 0 2 2 2 0 Zinc-finger double domain Tir_receptor_C PF07489.11 EFA84451.1 - 1.2 9.1 12.6 1.2 9.0 12.6 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus FmiP_Thoc5 PF09766.9 EFA84452.1 - 4.8e-71 240.0 12.4 4.8e-71 240.0 12.4 2.8 3 0 0 3 3 3 1 Fms-interacting protein/Thoc5 HALZ PF02183.18 EFA84452.1 - 0.48 10.7 10.1 1.8 8.9 2.6 3.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper Kelch_4 PF13418.6 EFA84453.1 - 6.2e-05 22.9 1.6 7.4e-05 22.7 0.1 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA84453.1 - 9.8e-05 22.2 0.0 0.00024 21.0 0.0 1.7 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 EFA84453.1 - 0.00016 21.2 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_5 PF13854.6 EFA84453.1 - 0.00053 19.9 0.0 0.0022 17.9 0.0 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 EFA84453.1 - 0.0032 17.7 0.0 0.0076 16.5 0.0 1.7 1 1 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 EFA84453.1 - 0.052 13.9 4.9 0.081 13.2 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF515 PF04415.12 EFA84453.1 - 8.9 4.6 12.2 11 4.3 12.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) CNDH2_C PF16858.5 EFA84454.1 - 2.5e-50 172.0 0.2 2.5e-50 172.0 0.2 5.2 2 2 1 3 3 3 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.11 EFA84454.1 - 5e-39 133.0 0.1 5e-39 133.0 0.1 6.6 5 1 0 5 5 5 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal TFIIA PF03153.13 EFA84454.1 - 0.0027 17.8 21.6 0.0027 17.8 21.6 3.4 3 1 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit ParA PF10609.9 EFA84455.1 - 9.5e-98 326.5 0.0 1.1e-97 326.3 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFA84455.1 - 1.2e-11 44.8 0.0 2.4e-11 43.8 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFA84455.1 - 2.8e-10 40.4 0.0 7.6e-10 39.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFA84455.1 - 9.3e-08 31.6 0.8 6.9e-07 28.7 0.2 2.4 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EFA84455.1 - 2.8e-06 26.8 0.1 1.5e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 EFA84455.1 - 0.00041 19.9 0.0 0.002 17.6 0.1 1.9 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MeaB PF03308.16 EFA84455.1 - 0.0012 17.9 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 EFA84455.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 EFA84455.1 - 0.0031 17.2 0.0 0.032 13.9 0.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EFA84455.1 - 0.0034 16.9 0.0 0.016 14.7 0.0 1.9 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 EFA84455.1 - 0.0039 16.8 0.0 0.006 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 EFA84455.1 - 0.0042 16.9 0.1 1.2 9.0 0.3 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFA84455.1 - 0.0051 16.0 0.1 0.0081 15.4 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain GFO_IDH_MocA PF01408.22 EFA84455.1 - 0.0077 17.1 0.0 6.8 7.5 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase family, NAD-binding Rossmann fold RsgA_GTPase PF03193.16 EFA84455.1 - 0.015 15.2 0.1 0.032 14.1 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase APS_kinase PF01583.20 EFA84455.1 - 0.048 13.6 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Rad17 PF03215.15 EFA84455.1 - 0.068 13.1 0.2 0.22 11.4 0.1 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 EFA84455.1 - 0.084 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 EFA84455.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Ank_2 PF12796.7 EFA84457.1 - 0.00027 21.5 0.1 0.032 14.8 0.0 2.4 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84457.1 - 0.00044 20.8 0.2 0.0033 18.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) HTH_DeoR PF08220.12 EFA84457.1 - 0.027 14.2 0.0 4.5 7.1 0.0 3.3 3 0 0 3 3 3 0 DeoR-like helix-turn-helix domain CALCOCO1 PF07888.11 EFA84458.1 - 0.0058 15.6 11.4 0.0082 15.1 11.4 1.4 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2992 PF11208.8 EFA84458.1 - 0.37 11.0 13.3 0.52 10.6 11.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2992) DUF4482 PF14818.6 EFA84458.1 - 1.6 9.6 11.3 0.73 10.7 8.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) TPR_17 PF13431.6 EFA84459.1 - 2.8e-86 277.9 15.9 4.1e-11 42.4 0.1 10.7 9 2 1 10 10 10 9 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84459.1 - 8e-17 60.6 17.5 0.0058 16.3 0.9 9.0 9 0 0 9 9 9 5 TPR repeat Myco_19_kDa PF05481.12 EFA84459.1 - 1.1e-05 25.7 0.9 10 6.5 0.4 5.3 1 1 2 4 4 4 0 Mycobacterium 19 kDa lipoprotein antigen DUF2155 PF09923.9 EFA84459.1 - 2.6e-05 24.4 2.0 26 5.2 0.0 5.9 3 2 3 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2155) Anth_Ig PF05587.13 EFA84459.1 - 7.3e-05 23.0 10.8 13 6.2 0.0 7.0 8 0 0 8 8 8 0 Anthrax receptor extracellular domain NleF_casp_inhib PF16809.5 EFA84459.1 - 0.00031 20.7 6.8 0.62 10.0 0.8 5.4 2 2 5 7 7 7 1 NleF caspase inhibitor DUF1153 PF06627.11 EFA84459.1 - 0.00093 19.3 0.1 63 3.8 0.0 6.5 8 0 0 8 8 8 0 Protein of unknown function (DUF1153) P22_CoatProtein PF11651.8 EFA84459.1 - 0.005 15.5 0.2 0.19 10.3 0.1 3.2 2 1 2 4 4 4 1 P22 coat protein - gene protein 5 YjzC PF14168.6 EFA84459.1 - 0.0094 16.3 0.3 14 6.2 0.0 4.7 4 3 2 6 6 5 0 YjzC-like protein WGR PF05406.15 EFA84459.1 - 0.021 14.9 0.5 11 6.1 0.0 3.7 4 0 0 4 4 4 0 WGR domain DUF3431 PF11913.8 EFA84459.1 - 0.038 13.8 1.2 0.52 10.1 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3431) DUF1344 PF07076.11 EFA84459.1 - 0.04 13.8 3.7 28 4.7 0.0 5.1 6 0 0 6 6 5 0 Protein of unknown function (DUF1344) ImmE5 PF11480.8 EFA84459.1 - 0.067 13.7 0.2 20 5.8 0.0 4.0 4 2 1 5 5 5 0 Colicin-E5 Imm protein TPR_20 PF14561.6 EFA84459.1 - 0.093 13.1 0.0 19 5.6 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA84459.1 - 0.17 11.8 18.7 1.1 9.1 0.0 9.1 12 0 0 12 12 12 0 Tetratricopeptide repeat Laminin_B PF00052.18 EFA84459.1 - 0.17 11.8 5.3 1.7 8.6 1.3 2.7 2 0 0 2 2 2 0 Laminin B (Domain IV) TPR_12 PF13424.6 EFA84459.1 - 0.49 10.7 5.2 31 4.9 0.0 5.4 5 2 3 8 8 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA84459.1 - 0.54 10.6 10.3 3.5 8.1 0.0 6.9 10 0 0 10 10 9 0 Tetratricopeptide repeat DUF4468 PF14730.6 EFA84459.1 - 2.5 8.5 6.3 12 6.3 0.1 4.1 4 1 0 4 4 4 0 Domain of unknown function (DUF4468) with TBP-like fold TPR_7 PF13176.6 EFA84459.1 - 2.9 8.1 5.0 5.9 7.2 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat HMMR_N PF15905.5 EFA84460.1 - 9.2e-05 22.1 11.0 9.2e-05 22.1 11.0 3.7 4 0 0 4 4 4 1 Hyaluronan mediated motility receptor N-terminal DUF641 PF04859.12 EFA84460.1 - 0.0084 16.4 2.8 0.0084 16.4 2.8 2.9 2 1 0 2 2 2 1 Plant protein of unknown function (DUF641) Motile_Sperm PF00635.26 EFA84460.1 - 0.021 14.7 1.5 4 7.3 0.0 3.5 3 0 0 3 3 3 0 MSP (Major sperm protein) domain DUF501 PF04417.12 EFA84460.1 - 0.48 10.2 2.9 1.2 9.0 2.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF501) Fez1 PF06818.15 EFA84460.1 - 3.2 8.2 30.1 4.1 7.8 9.8 2.8 1 1 1 2 2 2 0 Fez1 ATG11 PF10377.9 EFA84461.1 - 2.4e-08 34.1 0.0 2.4e-08 34.1 0.0 6.0 5 3 1 6 6 6 1 Autophagy-related protein 11 APG17 PF04108.12 EFA84461.1 - 2.8e-08 33.3 12.4 1.3e-06 27.8 0.8 7.9 2 2 4 6 6 6 2 Autophagy protein Apg17 ubiquitin PF00240.23 EFA84461.1 - 0.00014 21.5 0.1 0.00014 21.5 0.1 7.2 9 1 0 9 9 9 1 Ubiquitin family Spc7 PF08317.11 EFA84461.1 - 0.0015 17.4 21.5 0.0015 17.4 21.5 8.3 2 2 7 9 9 9 6 Spc7 kinetochore protein Trimer_CC PF08954.11 EFA84461.1 - 0.17 11.5 0.1 0.17 11.5 0.1 6.8 9 0 0 9 9 9 0 Trimerisation motif AAA_lid_1 PF17857.1 EFA84462.1 - 0.017 15.4 2.0 0.018 15.3 0.3 1.9 1 1 1 2 2 2 0 AAA+ lid domain TRP_N PF14558.6 EFA84462.1 - 0.11 12.8 0.1 0.26 11.7 0.1 1.6 1 0 0 1 1 1 0 ML-like domain TatD_DNase PF01026.21 EFA84463.1 - 7.1e-38 130.4 0.0 8.4e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase BCAS3 PF12490.8 EFA84464.1 - 0.18 11.3 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 TPR_17 PF13431.6 EFA84465.1 - 3.4e-112 359.0 19.4 3.4e-11 42.7 0.0 11.5 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84465.1 - 1.2e-17 63.2 20.6 0.079 12.7 0.2 9.8 10 0 0 10 10 10 8 TPR repeat Anth_Ig PF05587.13 EFA84465.1 - 7.3e-09 35.9 8.8 16 5.9 0.0 8.2 8 1 0 8 8 8 1 Anthrax receptor extracellular domain DUF1153 PF06627.11 EFA84465.1 - 6.9e-06 26.1 2.2 27 5.0 0.0 8.3 10 0 0 10 10 10 0 Protein of unknown function (DUF1153) Ntox46 PF15538.6 EFA84465.1 - 0.00023 21.2 5.2 17 5.4 0.0 6.8 1 1 7 9 9 9 1 Bacterial toxin 46 ACT_5 PF13710.6 EFA84465.1 - 0.00075 19.3 0.2 8.7 6.3 0.0 4.1 3 0 0 3 3 3 1 ACT domain RVT_thumb PF06817.14 EFA84465.1 - 0.00089 19.1 5.7 61 3.6 0.0 6.9 7 1 0 7 7 7 0 Reverse transcriptase thumb domain DUF1344 PF07076.11 EFA84465.1 - 0.0035 17.2 17.0 42 4.2 0.0 7.8 9 0 0 9 9 9 0 Protein of unknown function (DUF1344) NleF_casp_inhib PF16809.5 EFA84465.1 - 0.011 15.6 9.9 73 3.2 0.0 7.2 5 4 4 9 9 9 0 NleF caspase inhibitor DUF4990 PF16380.5 EFA84465.1 - 0.74 9.9 12.0 37 4.4 0.1 5.9 6 1 0 7 7 7 0 Domain of unknown function ANAPC4_WD40 PF12894.7 EFA84466.1 - 6.9e-11 42.3 0.6 0.0049 17.1 0.0 5.0 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFA84466.1 - 1.7e-06 28.6 5.1 3.7 8.6 0.1 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat Gmad1 PF10647.9 EFA84466.1 - 0.084 12.6 0.2 4.5 6.9 0.0 2.7 2 1 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 EFA84466.1 - 0.094 12.7 0.2 1.9 8.5 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PH PF00169.29 EFA84467.1 - 2.3e-16 60.2 0.2 2.3e-16 60.2 0.2 1.9 2 1 0 2 2 2 1 PH domain SH3_9 PF14604.6 EFA84467.1 - 1.3e-10 41.0 0.1 2.2e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFA84467.1 - 1.8e-08 33.9 0.2 3.6e-08 32.9 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA84467.1 - 6.6e-06 25.7 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EFA84467.1 - 0.00055 20.3 8.9 0.033 14.6 2.6 3.5 2 1 0 2 2 2 2 Pleckstrin homology domain TFIIA PF03153.13 EFA84467.1 - 0.0086 16.1 16.5 0.01 15.9 16.5 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PH_8 PF15409.6 EFA84467.1 - 0.055 13.7 0.3 0.24 11.7 0.3 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 EFA84467.1 - 0.083 13.3 0.5 2.9 8.3 0.5 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain MAP70 PF07058.11 EFA84467.1 - 0.34 9.6 3.9 0.51 9.0 3.9 1.3 1 0 0 1 1 1 0 Microtubule-associated protein 70 GREB1 PF15782.5 EFA84467.1 - 1.8 5.6 18.1 2.2 5.3 18.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RIFIN PF02009.16 EFA84468.1 - 0.14 12.0 8.0 0.17 11.7 8.0 1.2 1 0 0 1 1 1 0 Rifin Plasmodium_Vir PF05795.11 EFA84468.1 - 2.2 7.6 7.8 3 7.1 7.8 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SOG2 PF10428.9 EFA84468.1 - 2.7 7.1 24.0 3.4 6.8 24.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Cyto_heme_lyase PF01265.17 EFA84468.1 - 3.3 7.2 6.8 5.3 6.6 6.8 1.2 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase Joubert PF15392.6 EFA84468.1 - 6.5 6.4 10.2 9.2 5.9 10.2 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated TTL PF03133.15 EFA84469.1 - 1.5e-50 172.0 1.5 2.6e-50 171.2 1.5 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 EFA84469.1 - 0.01 15.1 0.1 2.9 7.1 0.0 2.4 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EFA84469.1 - 0.028 14.4 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain GSP_synth PF03738.14 EFA84469.1 - 0.029 13.5 0.2 0.09 11.9 0.1 1.8 1 1 1 2 2 2 0 Glutathionylspermidine synthase preATP-grasp Planc_extracel PF07595.12 EFA84469.1 - 0.15 11.9 0.2 0.35 10.7 0.2 1.6 1 0 0 1 1 1 0 Planctomycete extracellular FNIP PF05725.12 EFA84470.1 - 1.6e-20 73.0 6.7 2.8e-09 37.0 0.7 8.4 2 2 6 8 8 8 6 FNIP Repeat F-box-like PF12937.7 EFA84470.1 - 0.0014 18.5 0.1 0.0041 17.0 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA84470.1 - 0.011 15.3 0.3 0.022 14.3 0.3 1.5 1 0 0 1 1 1 0 F-box Ank_2 PF12796.7 EFA84471.1 - 1.2e-15 57.9 0.0 0.002 18.7 0.0 5.5 3 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84471.1 - 1.6e-13 50.9 0.1 0.031 14.9 0.0 6.7 5 3 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84471.1 - 2e-10 40.0 0.7 7.2 7.5 0.0 8.2 9 1 1 10 10 10 2 Ankyrin repeat Ank_5 PF13857.6 EFA84471.1 - 7.2e-09 35.7 0.0 0.13 12.6 0.0 6.3 4 1 3 7 7 7 2 Ankyrin repeats (many copies) DED PF01335.21 EFA84471.1 - 0.05 13.9 1.2 28 5.1 0.0 3.8 4 0 0 4 4 4 0 Death effector domain RelA_SpoT PF04607.17 EFA84472.1 - 6e-24 84.6 0.3 6e-24 84.6 0.3 2.6 2 1 1 3 3 3 1 Region found in RelA / SpoT proteins ATG7_N PF16420.5 EFA84473.1 - 8.3e-89 298.2 0.3 1.7e-88 297.1 0.2 1.6 2 0 0 2 2 2 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EFA84473.1 - 3e-42 144.7 0.0 4.9e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EFA84473.1 - 0.0084 16.2 0.0 0.54 10.3 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFA84473.1 - 0.06 12.7 0.0 2.2 7.6 0.0 2.9 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Med13_C PF06333.12 EFA84474.1 - 7.4 5.7 10.6 7.6 5.7 10.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain TPR_17 PF13431.6 EFA84475.1 - 6.9e-16 57.4 0.5 3.7e-11 42.6 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84475.1 - 1.4e-05 24.7 0.1 0.00024 20.7 0.1 2.1 2 0 0 2 2 2 1 TPR repeat Lum_binding PF00677.17 EFA84475.1 - 0.025 14.6 0.0 0.66 10.0 0.0 2.1 1 1 0 1 1 1 0 Lumazine binding domain TPR_8 PF13181.6 EFA84475.1 - 0.031 14.5 0.1 35 4.9 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Lyx_isomer PF07385.12 EFA84475.1 - 0.088 12.1 0.0 5.5 6.2 0.0 2.2 1 1 1 2 2 2 0 D-lyxose isomerase TPR_1 PF00515.28 EFA84475.1 - 0.14 12.1 0.1 6.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Epiglycanin_TR PF05647.11 EFA84475.1 - 0.29 11.1 1.6 7.6 6.5 0.2 2.1 2 0 0 2 2 2 0 Tandem-repeating region of mucin, epiglycanin-like TPR_17 PF13431.6 EFA84476.1 - 1e-59 194.7 8.5 5.4e-12 45.2 0.0 6.1 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84476.1 - 8.3e-12 44.6 11.6 0.024 14.3 0.1 5.6 6 0 0 6 6 6 5 TPR repeat Anth_Ig PF05587.13 EFA84476.1 - 0.00018 21.8 1.4 3.9 7.8 0.0 4.0 4 0 0 4 4 4 2 Anthrax receptor extracellular domain DUF3255 PF11631.8 EFA84476.1 - 0.00032 20.6 2.9 1 9.3 0.0 3.9 2 1 2 4 4 4 1 Protein of unknown function (DUF3255) NleF_casp_inhib PF16809.5 EFA84476.1 - 0.0014 18.6 1.3 3.5 7.5 0.1 3.6 3 1 1 4 4 4 1 NleF caspase inhibitor P22_CoatProtein PF11651.8 EFA84476.1 - 0.0024 16.5 0.1 0.43 9.1 0.0 2.9 2 1 1 3 3 3 1 P22 coat protein - gene protein 5 TPR_2 PF07719.17 EFA84476.1 - 0.0046 17.0 3.0 48 4.4 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2155 PF09923.9 EFA84476.1 - 0.011 16.0 0.2 4.2 7.7 0.0 3.4 2 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2155) TPR_1 PF00515.28 EFA84476.1 - 0.98 9.4 13.5 34 4.5 0.0 7.0 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA84477.1 - 3.7e-192 609.5 31.1 4.4e-11 42.4 0.1 19.9 19 1 0 19 19 19 18 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84477.1 - 2.9e-22 78.1 32.9 0.25 11.1 0.1 15.2 16 0 0 16 16 16 7 TPR repeat Trypsin_2 PF13365.6 EFA84477.1 - 1.1e-14 55.6 0.0 1.2e-05 26.3 0.0 3.0 2 1 0 2 2 2 2 Trypsin-like peptidase domain Tudor_RapA PF18337.1 EFA84477.1 - 1.6e-05 24.9 0.3 60 3.9 0.0 8.3 7 0 0 7 7 7 0 RapA N-terminal Tudor like domain Trypsin PF00089.26 EFA84477.1 - 5.9e-05 23.0 0.0 0.048 13.5 0.0 3.1 2 1 0 2 2 2 2 Trypsin DUF2155 PF09923.9 EFA84477.1 - 0.004 17.4 5.0 63 3.9 0.0 7.4 7 2 3 10 10 10 0 Uncharacterized protein conserved in bacteria (DUF2155) Ntox46 PF15538.6 EFA84477.1 - 0.028 14.4 4.7 90 3.0 0.0 7.6 4 3 2 10 10 10 0 Bacterial toxin 46 Anth_Ig PF05587.13 EFA84477.1 - 0.061 13.6 38.2 68 3.9 0.0 14.2 17 1 1 18 18 18 0 Anthrax receptor extracellular domain TPR_2 PF07719.17 EFA84477.1 - 0.063 13.4 11.0 4.6e+02 1.4 0.0 10.1 14 0 0 14 14 14 0 Tetratricopeptide repeat NleF_casp_inhib PF16809.5 EFA84477.1 - 0.8 9.6 22.3 1.1e+02 2.6 0.1 11.1 11 5 3 14 14 14 0 NleF caspase inhibitor Peptidase_C3 PF00548.20 EFA84477.1 - 7.2 6.5 7.0 0.75 9.7 0.3 2.9 3 0 0 3 3 3 0 3C cysteine protease (picornain 3C) Trypsin_2 PF13365.6 EFA84478.1 - 1.1e-16 62.1 0.0 1.7e-16 61.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA84478.1 - 0.00023 21.0 0.1 0.045 13.6 0.0 2.3 2 0 0 2 2 2 2 Trypsin Peptidase_S46 PF10459.9 EFA84478.1 - 0.11 11.2 0.1 0.16 10.6 0.1 1.2 1 0 0 1 1 1 0 Peptidase S46 Trypsin_2 PF13365.6 EFA84479.1 - 6.2e-09 36.9 0.0 1.4e-08 35.8 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFA84479.1 - 9.8e-05 22.3 0.0 0.0066 16.3 0.0 2.1 1 1 0 1 1 1 1 Trypsin AMP-binding PF00501.28 EFA84480.1 - 8.5e-19 67.4 0.1 1.1e-18 67.0 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Aldolase_II PF00596.21 EFA84481.1 - 3.9e-41 141.0 0.4 4.9e-41 140.7 0.4 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Na_Ca_ex PF01699.24 EFA84482.1 - 1.6e-20 73.6 40.1 2.9e-12 46.8 6.4 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein YccF PF03733.13 EFA84482.1 - 0.0016 19.1 5.6 0.0016 19.1 5.6 6.4 6 1 0 6 6 6 1 Inner membrane component domain ArabFuran-catal PF09206.11 EFA84482.1 - 0.045 13.0 3.4 0.072 12.4 3.4 1.2 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase B, catalytic PhoLip_ATPase_C PF16212.5 EFA84483.1 - 9.8e-51 172.9 21.5 9.8e-51 172.9 21.5 3.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA84483.1 - 1.2e-16 60.1 9.4 1.2e-16 60.1 9.4 2.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFA84483.1 - 2.1e-11 43.8 0.1 4.8e-09 36.2 0.0 3.1 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA84483.1 - 7.2e-11 42.8 0.2 0.00075 19.8 0.0 3.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFA84483.1 - 1.1e-09 38.0 2.0 1.7e-09 37.5 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFA84483.1 - 0.00081 19.2 0.1 0.00081 19.2 0.1 3.6 2 2 1 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 EFA84483.1 - 0.64 9.7 12.2 2.9 7.5 12.2 2.2 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Kelch_4 PF13418.6 EFA84484.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain zf-B_box PF00643.24 EFA84485.1 - 0.94 9.7 14.6 3.2 8.0 14.6 2.0 1 0 0 1 1 1 0 B-box zinc finger Pkinase PF00069.25 EFA84486.1 - 3.1e-28 98.9 0.1 1.3e-24 87.0 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84486.1 - 0.00012 21.5 0.1 0.0022 17.3 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase ASD2 PF08687.11 EFA84486.1 - 0.11 12.1 2.5 0.14 11.7 2.5 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 WTF PF03303.13 EFA84486.1 - 0.73 9.5 0.0 0.73 9.5 0.0 2.2 2 1 0 2 2 2 0 WTF protein Ribosomal_S14 PF00253.21 EFA84487.1 - 3.1e-10 39.7 4.2 4.7e-10 39.1 4.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF1451 PF07295.11 EFA84487.1 - 0.037 14.0 0.8 0.049 13.7 0.8 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-AD PF07776.15 EFA84487.1 - 0.69 10.2 4.6 4.1 7.7 0.5 2.2 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) Mob1_phocein PF03637.17 EFA84488.1 - 5.6e-09 36.2 0.4 8.2e-09 35.7 0.2 1.3 1 1 0 1 1 1 1 Mob1/phocein family Mob1_phocein PF03637.17 EFA84489.1 - 1.1e-08 35.3 3.7 1.2e-08 35.1 3.7 1.0 1 0 0 1 1 1 1 Mob1/phocein family Pkinase_Tyr PF07714.17 EFA84490.1 - 3.8e-48 164.0 0.0 9.3e-48 162.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA84490.1 - 1.1e-43 149.5 0.0 1.8e-43 148.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain C2 PF00168.30 EFA84490.1 - 1.2e-22 80.1 0.0 3.4e-22 78.7 0.0 1.8 1 0 0 1 1 1 1 C2 domain Ank_2 PF12796.7 EFA84490.1 - 7.6e-19 68.1 0.7 3.7e-11 43.4 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84490.1 - 4.3e-16 59.1 1.3 1.3e-06 28.8 0.0 4.6 2 1 3 5 5 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84490.1 - 3.9e-15 55.7 0.1 3.1e-07 30.5 0.0 5.1 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84490.1 - 7.9e-12 44.3 1.8 1.3e-05 25.1 0.0 5.2 6 0 0 6 6 4 2 Ankyrin repeat Ank PF00023.30 EFA84490.1 - 3.5e-10 39.9 0.2 0.00066 20.0 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat SAM_2 PF07647.17 EFA84490.1 - 1.6e-07 31.3 0.1 5.6e-07 29.6 0.1 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFA84490.1 - 6.5e-07 29.7 0.1 1.6e-06 28.5 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RIO1 PF01163.22 EFA84490.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFA84490.1 - 0.09 12.7 2.7 0.16 11.9 0.1 2.4 2 1 0 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFA84490.1 - 0.13 11.2 6.7 1.1 8.1 6.7 2.3 1 1 0 1 1 1 0 Haspin like kinase domain RRM_1 PF00076.22 EFA84492.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_11 PF08241.12 EFA84493.1 - 1e-23 83.8 0.0 3.6e-23 82.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA84493.1 - 7.4e-21 74.5 0.0 1.6e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84493.1 - 1.7e-20 73.5 0.0 4.1e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA84493.1 - 2.5e-16 59.8 0.0 5e-16 58.7 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFA84493.1 - 4.2e-16 59.2 0.0 6.7e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84493.1 - 1.6e-13 51.2 0.0 2.3e-12 47.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EFA84493.1 - 5.2e-11 42.4 0.0 8.8e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Polyketide_cyc2 PF10604.9 EFA84493.1 - 6.6e-08 32.9 0.1 1.8e-07 31.5 0.1 1.7 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Methyltransf_8 PF05148.15 EFA84493.1 - 0.00015 21.7 0.0 0.0008 19.3 0.0 2.0 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_15 PF09445.10 EFA84493.1 - 0.0003 20.4 0.1 0.0026 17.4 0.0 2.2 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase MetW PF07021.12 EFA84493.1 - 0.0013 18.3 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EFA84493.1 - 0.0016 18.0 0.0 0.0043 16.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain COXG PF06240.13 EFA84493.1 - 0.0018 18.0 0.3 0.0041 16.9 0.3 1.6 1 1 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DOT1 PF08123.13 EFA84493.1 - 0.005 16.4 0.3 0.012 15.2 0.0 1.7 2 0 0 2 2 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 EFA84493.1 - 0.0088 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EFA84493.1 - 0.017 14.4 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain TehB PF03848.14 EFA84493.1 - 0.019 14.4 0.0 0.041 13.3 0.0 1.6 1 0 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 EFA84493.1 - 0.059 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) N6_N4_Mtase PF01555.18 EFA84493.1 - 0.089 12.5 0.1 9 5.9 0.1 2.2 2 0 0 2 2 2 0 DNA methylase ADH_zinc_N PF00107.26 EFA84493.1 - 0.091 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_4 PF02390.17 EFA84493.1 - 0.1 12.1 0.0 0.47 9.9 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Peptidase_C15 PF01470.17 EFA84495.1 - 5e-15 56.2 0.0 1.9e-14 54.3 0.0 1.7 1 1 0 1 1 1 1 Pyroglutamyl peptidase HD_4 PF13328.6 EFA84496.1 - 8.9e-19 67.8 0.2 1.2e-18 67.3 0.2 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 EFA84496.1 - 0.00012 22.3 0.7 0.00026 21.2 0.7 1.6 1 0 0 1 1 1 1 HD domain Lung_7-TM_R PF06814.13 EFA84497.1 - 1.9e-54 184.9 28.6 2.4e-54 184.6 28.6 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SURF1 PF02104.15 EFA84498.1 - 1.4e-39 136.2 0.0 1.9e-39 135.7 0.0 1.2 1 0 0 1 1 1 1 SURF1 family CBM49 PF09478.10 EFA84498.1 - 1.5e-12 47.6 1.3 5e-12 46.0 1.3 1.9 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 TPR_17 PF13431.6 EFA84499.1 - 1.7e-80 259.8 18.3 7.9e-09 35.3 0.1 10.7 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84499.1 - 3.6e-09 36.2 18.5 0.21 11.3 0.3 9.0 10 0 0 10 10 10 4 TPR repeat Anth_Ig PF05587.13 EFA84499.1 - 5.5e-08 33.1 4.7 27 5.2 0.0 7.5 8 0 0 8 8 8 0 Anthrax receptor extracellular domain TPR_8 PF13181.6 EFA84499.1 - 0.0021 18.1 1.2 12 6.4 0.0 6.5 8 1 0 8 8 8 1 Tetratricopeptide repeat DUF2155 PF09923.9 EFA84499.1 - 0.003 17.8 1.1 24 5.2 0.0 5.3 4 2 2 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2155) DUF3048_C PF17479.2 EFA84499.1 - 0.0083 16.5 0.3 1.2e+02 3.1 0.0 5.3 5 1 0 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain NleF_casp_inhib PF16809.5 EFA84499.1 - 0.027 14.4 0.8 2.6e+02 1.5 0.0 5.7 6 1 1 7 7 7 0 NleF caspase inhibitor DUF1344 PF07076.11 EFA84499.1 - 0.027 14.4 2.9 24 4.9 0.1 5.5 6 0 0 6 6 6 0 Protein of unknown function (DUF1344) Sld5 PF05916.11 EFA84499.1 - 0.076 13.5 3.3 0.2 12.1 0.1 3.1 3 1 0 3 3 3 0 GINS complex protein Epiglycanin_TR PF05647.11 EFA84499.1 - 9.3 6.2 20.3 46 4.0 0.3 6.5 7 0 0 7 7 7 0 Tandem-repeating region of mucin, epiglycanin-like PRKCSH_1 PF13015.6 EFA84500.1 - 4.3e-07 29.7 0.8 5.9e-07 29.3 0.8 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 EFA84501.1 - 1.2e-10 41.3 0.1 1.7e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA84501.1 - 1.5e-08 34.8 2.8 1.9e-06 28.0 1.6 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat DUF4097 PF13349.6 EFA84501.1 - 0.00023 20.6 1.6 0.00029 20.3 1.6 1.1 1 0 0 1 1 1 1 Putative adhesin Man-6-P_recep PF02157.15 EFA84501.1 - 0.0022 17.1 0.0 0.003 16.7 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Glycoprotein PF03409.15 EFA84501.1 - 0.11 11.3 8.0 0.16 10.8 8.0 1.2 1 0 0 1 1 1 0 Transmembrane glycoprotein Copine PF07002.16 EFA84503.1 - 2.4e-69 233.1 0.1 3.5e-69 232.6 0.1 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFA84503.1 - 4.9e-22 78.2 0.0 5.2e-10 39.5 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFA84503.1 - 6.7e-06 26.4 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFA84503.1 - 0.012 15.8 0.2 0.024 14.9 0.2 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain Copine PF07002.16 EFA84504.1 - 1.4e-68 230.6 0.1 2.1e-68 230.0 0.1 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFA84504.1 - 3.7e-19 68.9 0.1 8.6e-09 35.6 0.0 2.5 2 0 0 2 2 2 2 C2 domain LPMO_10 PF03067.15 EFA84504.1 - 5.7e-13 50.0 0.6 2.8e-09 37.9 0.5 2.7 1 1 1 2 2 2 2 Lytic polysaccharide mono-oxygenase, cellulose-degrading vWA-TerF-like PF10138.9 EFA84504.1 - 3.4e-05 24.1 0.0 6.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus Malate_DH PF12434.8 EFA84504.1 - 2 8.5 5.0 4.1 7.5 5.0 1.6 1 0 0 1 1 1 0 Malate dehydrogenase enzyme Ank_2 PF12796.7 EFA84506.1 - 2.4e-37 127.4 13.7 1.7e-07 31.7 0.0 7.6 1 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84506.1 - 7.5e-25 87.0 12.2 0.00056 20.4 0.0 10.9 5 5 7 12 12 12 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84506.1 - 1e-22 79.8 15.2 0.043 14.2 0.0 12.0 3 2 7 12 12 12 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84506.1 - 2.5e-14 52.0 6.9 0.61 10.8 0.0 12.6 13 3 3 16 16 16 2 Ankyrin repeat Ank PF00023.30 EFA84506.1 - 0.00012 22.4 9.0 5.5 7.6 0.1 9.1 6 3 3 9 9 9 1 Ankyrin repeat DUF4460 PF14687.6 EFA84506.1 - 0.016 15.3 0.6 0.06 13.4 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4460) DUF1843 PF08898.10 EFA84506.1 - 0.041 14.4 1.1 32 5.1 0.0 4.3 6 0 0 6 6 6 0 Domain of unknown function (DUF1843) CBM49 PF09478.10 EFA84507.1 - 2.6e-17 62.9 1.7 4e-17 62.3 1.7 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 SH3_10 PF17902.1 EFA84507.1 - 0.056 13.5 0.2 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 SH3 domain AP3B1_C PF14796.6 EFA84507.1 - 0.12 12.6 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal ACOX PF01756.19 EFA84508.1 - 1e-31 109.9 2.3 1.4e-31 109.5 1.0 1.8 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFA84508.1 - 1.9e-20 72.8 0.0 3.6e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFA84508.1 - 5.5e-07 29.9 0.0 2.3e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain NPA PF16469.5 EFA84508.1 - 0.51 10.9 5.2 1.7 9.2 2.9 2.2 1 1 1 2 2 2 0 Nematode polyprotein allergen ABA-1 CBM49 PF09478.10 EFA84509.1 - 1.3e-16 60.7 0.1 1.9e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Lactamase_B_2 PF12706.7 EFA84510.1 - 1.7e-34 119.1 0.1 2.7e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFA84510.1 - 3.4e-14 53.1 0.0 4.6e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AMP-binding PF00501.28 EFA84511.1 - 1.6e-106 356.4 0.0 2.2e-106 356.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFA84511.1 - 0.001 20.0 0.0 0.0024 18.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CDP-OH_P_transf PF01066.21 EFA84512.1 - 3.1e-11 43.9 0.0 3.1e-11 43.9 0.0 3.4 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase UPF0020 PF01170.18 EFA84514.1 - 2.2e-18 66.7 0.1 7e-13 48.7 0.0 2.6 2 1 1 3 3 3 2 Putative RNA methylase family UPF0020 CheR PF01739.18 EFA84514.1 - 0.00042 19.8 1.7 0.00085 18.9 1.7 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain N6_N4_Mtase PF01555.18 EFA84514.1 - 0.0013 18.5 0.0 0.01 15.5 0.0 2.5 2 1 0 2 2 2 1 DNA methylase Robl_LC7 PF03259.17 EFA84515.1 - 0.0022 17.7 0.1 0.0049 16.6 0.1 1.6 1 0 0 1 1 1 1 Roadblock/LC7 domain PPR_2 PF13041.6 EFA84516.1 - 0.0093 16.1 0.6 0.049 13.8 0.2 2.6 2 0 0 2 2 2 1 PPR repeat family TFIIF_beta PF02270.15 EFA84517.1 - 3.2e-23 81.6 0.6 5e-23 81.0 0.6 1.3 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EFA84517.1 - 1e-07 32.7 0.4 2e-07 31.8 0.2 1.8 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus Tau95 PF09734.9 EFA84517.1 - 0.0059 17.4 1.2 0.0088 16.9 1.2 1.2 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain PLDc PF00614.22 EFA84518.1 - 1.2e-18 66.5 1.9 2.4e-08 33.8 0.1 3.0 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFA84518.1 - 2e-11 43.9 0.3 2.9e-09 36.9 0.4 3.9 4 0 0 4 4 4 2 PLD-like domain Lin-8 PF03353.15 EFA84518.1 - 0.005 16.5 7.5 0.005 16.5 7.5 4.7 2 1 1 3 3 3 1 Ras-mediated vulval-induction antagonist NAM-associated PF14303.6 EFA84518.1 - 0.078 13.7 0.0 0.078 13.7 0.0 5.8 2 2 2 5 5 5 0 No apical meristem-associated C-terminal domain HLH PF00010.26 EFA84519.1 - 0.0038 17.1 1.3 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MINDY_DUB PF04424.13 EFA84520.1 - 7.1e-16 58.3 0.7 1.4e-15 57.3 0.7 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase Myosin_head PF00063.21 EFA84521.1 - 3.7e-154 514.6 20.2 6.4e-154 513.8 20.2 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 EFA84521.1 - 1.3e-56 189.7 0.0 9.7e-30 103.3 0.0 2.9 2 0 0 2 2 2 2 MyTH4 domain FERM_M PF00373.18 EFA84521.1 - 2.7e-20 72.9 0.3 3.3e-11 43.6 0.0 3.2 2 0 0 2 2 2 2 FERM central domain SH3_2 PF07653.17 EFA84521.1 - 1.4e-08 34.2 0.0 3.5e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain RA PF00788.23 EFA84521.1 - 5.5e-08 33.3 0.0 0.00031 21.3 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain SH3_1 PF00018.28 EFA84521.1 - 5.3e-05 22.7 0.0 0.00012 21.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA84521.1 - 7.1e-05 22.6 0.0 0.00026 20.8 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain FERM_N PF09379.10 EFA84521.1 - 0.057 13.4 0.0 11 6.1 0.0 2.9 2 0 0 2 2 2 0 FERM N-terminal domain DUF3128 PF11326.8 EFA84522.1 - 0.057 13.8 0.0 0.078 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3128) Lectin_leg-like PF03388.13 EFA84523.1 - 3.5e-61 206.5 0.3 3.5e-61 206.5 0.3 1.8 2 0 0 2 2 2 1 Legume-like lectin family TFIIA PF03153.13 EFA84523.1 - 0.0022 18.1 41.1 0.0035 17.4 41.1 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 EFA84523.1 - 0.52 8.5 36.0 0.75 8.0 36.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM222A PF15258.6 EFA84523.1 - 2.3 7.2 26.7 3.8 6.5 26.7 1.3 1 0 0 1 1 1 0 Protein family of FAM222A Caldesmon PF02029.15 EFA84523.1 - 9.7 4.8 28.6 13 4.4 28.6 1.1 1 0 0 1 1 1 0 Caldesmon GSIII_N PF12437.8 EFA84524.1 - 4.6e-70 234.4 0.0 8.1e-70 233.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C-ter PF18318.1 EFA84524.1 - 3.5e-39 133.3 0.1 8.2e-39 132.1 0.1 1.7 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain Gln-synt_C PF00120.24 EFA84524.1 - 4.3e-18 65.4 0.0 7.2e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain GN3L_Grn1 PF08701.11 EFA84526.1 - 4e-21 74.9 13.1 4e-21 74.9 13.1 4.1 3 1 1 4 4 4 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EFA84526.1 - 3.3e-17 62.6 0.4 1.7e-14 53.9 0.0 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA84526.1 - 1.5e-10 40.9 0.4 7.6e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA84526.1 - 5.8e-07 29.6 0.2 0.0084 16.0 0.1 2.7 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFA84526.1 - 9e-05 22.1 0.7 0.015 14.8 0.0 3.6 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EFA84526.1 - 0.013 15.9 2.2 0.065 13.6 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain Arf PF00025.21 EFA84526.1 - 0.057 12.9 0.2 0.67 9.4 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_18 PF13238.6 EFA84526.1 - 0.36 11.4 0.0 0.36 11.4 0.0 4.5 4 1 0 5 5 5 0 AAA domain ABC_tran PF00005.27 EFA84526.1 - 1.1 9.8 0.0 1.1 9.8 0.0 2.9 3 1 0 3 3 3 0 ABC transporter GHMP_kinases_N PF00288.26 EFA84527.1 - 2.3e-17 62.9 0.2 5.6e-17 61.7 0.2 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFA84527.1 - 0.00047 20.5 0.0 0.0014 19.0 0.0 1.9 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EFA84527.1 - 0.023 14.2 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature RuvB_N PF05496.12 EFA84527.1 - 0.061 13.1 0.0 13 5.5 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Ank_4 PF13637.6 EFA84528.1 - 1e-26 92.9 6.1 2.9e-06 27.7 0.1 5.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84528.1 - 2.8e-26 91.9 1.6 3.2e-14 53.3 0.6 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFA84528.1 - 6.3e-22 77.0 11.3 1.1e-05 25.7 0.1 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EFA84528.1 - 3.1e-21 73.2 7.8 2.9e-05 24.1 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFA84528.1 - 1.5e-13 50.7 1.5 0.0001 22.5 0.5 4.6 4 0 0 4 4 4 3 Ankyrin repeats (many copies) F-box PF00646.33 EFA84528.1 - 7.9e-09 35.2 3.5 1.8e-08 34.1 3.5 1.6 1 0 0 1 1 1 1 F-box domain SH2 PF00017.24 EFA84528.1 - 1.5e-08 34.6 0.0 4.3e-08 33.1 0.0 1.9 1 0 0 1 1 1 1 SH2 domain F-box-like PF12937.7 EFA84528.1 - 3.1e-08 33.4 2.3 6.5e-08 32.4 2.3 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFA84528.1 - 0.0013 18.6 0.6 0.0036 17.2 0.6 1.8 1 0 0 1 1 1 1 F-box SH2_2 PF14633.6 EFA84528.1 - 0.019 14.4 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 SH2 domain NmrA PF05368.13 EFA84529.1 - 1.3e-24 87.0 0.2 1.4e-24 86.9 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFA84529.1 - 3.6e-18 66.1 0.0 6.7e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EFA84529.1 - 0.00025 21.3 0.0 0.00066 19.9 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EFA84529.1 - 0.0018 17.4 0.3 0.47 9.5 0.0 2.7 2 1 0 2 2 2 2 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFA84529.1 - 0.005 16.0 0.2 0.053 12.7 0.1 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFA84529.1 - 0.018 14.1 0.4 0.046 12.7 0.4 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HTH_38 PF13936.6 EFA84529.1 - 0.021 14.6 0.1 8.5 6.2 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain TrkA_N PF02254.18 EFA84529.1 - 0.032 14.5 0.1 1.3 9.3 0.1 3.1 3 1 1 4 4 4 0 TrkA-N domain KR PF08659.10 EFA84529.1 - 0.058 13.3 0.1 0.22 11.4 0.1 2.1 1 1 0 1 1 1 0 KR domain Chlam_PMP PF02415.17 EFA84530.1 - 0.022 15.2 1.0 0.022 15.2 1.0 5.7 4 2 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat M60-like_N PF17291.2 EFA84530.1 - 0.038 13.9 0.5 5 7.0 0.1 2.7 1 1 1 2 2 2 0 N-terminal domain of M60-like peptidases DUF515 PF04415.12 EFA84530.1 - 2 6.7 14.7 3.8 5.8 14.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) GRIM-19 PF06212.12 EFA84531.1 - 0.84 9.6 2.9 1 9.3 0.3 2.0 1 1 1 2 2 2 0 GRIM-19 protein WH1 PF00568.23 EFA84533.1 - 9.8e-23 80.2 0.1 1.5e-22 79.6 0.1 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.11 EFA84533.1 - 5.2e-10 38.7 2.5 7.3e-10 38.2 2.5 1.2 1 0 0 1 1 1 1 VASP tetramerisation domain WH2 PF02205.20 EFA84533.1 - 5.5e-09 35.6 0.5 1.6e-08 34.1 0.5 1.9 1 0 0 1 1 1 1 WH2 motif Ran_BP1 PF00638.18 EFA84533.1 - 0.0015 18.8 0.0 0.0056 16.9 0.0 1.9 1 1 0 1 1 1 1 RanBP1 domain REPA_OB_2 PF16900.5 EFA84534.1 - 5.8e-15 55.0 0.6 1.1e-12 47.7 0.1 2.7 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EFA84534.1 - 1.1e-06 28.5 0.3 0.28 11.2 0.0 3.5 3 0 0 3 3 3 3 OB-fold nucleic acid binding domain Rep_fac-A_C PF08646.10 EFA84534.1 - 6.8e-05 22.6 4.5 0.00018 21.3 0.0 3.2 3 0 0 3 3 3 1 Replication factor-A C terminal domain SSB PF00436.25 EFA84534.1 - 0.009 16.0 0.0 0.066 13.3 0.0 2.4 2 0 0 2 2 2 1 Single-strand binding protein family Menin PF05053.13 EFA84534.1 - 0.48 8.7 9.8 0.8 8.0 9.8 1.2 1 0 0 1 1 1 0 Menin DUF4834 PF16118.5 EFA84534.1 - 0.65 11.0 3.2 2.8 9.0 3.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ly49 PF08391.10 EFA84534.1 - 3.6 8.0 7.9 0.25 11.7 2.3 2.0 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DivIC PF04977.15 EFA84535.1 - 3.7 7.4 10.6 3.5 7.4 10.6 1.0 1 0 0 1 1 1 0 Septum formation initiator Spt20 PF12090.8 EFA84535.1 - 6.7 6.2 23.0 6.8 6.2 23.0 1.0 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 EFA84535.1 - 9.8 7.2 11.4 10 7.2 11.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 EFA84536.1 - 1.8e-28 98.9 9.5 9.7e-10 38.9 0.2 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFA84536.1 - 2.5e-24 84.6 1.4 4.9e-05 23.6 0.0 6.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFA84536.1 - 7.6e-23 80.6 0.7 7.5e-07 29.6 0.3 4.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84536.1 - 3.2e-22 76.2 1.0 0.0012 19.2 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat Pkinase_Tyr PF07714.17 EFA84536.1 - 1.9e-19 70.0 0.1 9.1e-10 38.2 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase GRAM PF02893.20 EFA84536.1 - 6.5e-16 58.2 0.2 1.5e-15 57.0 0.2 1.6 1 0 0 1 1 1 1 GRAM domain Ank_5 PF13857.6 EFA84536.1 - 1.3e-15 57.2 14.9 1.8e-06 28.1 0.0 5.6 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Pkinase PF00069.25 EFA84536.1 - 6.2e-14 52.0 0.0 6.5e-09 35.5 0.1 2.5 1 1 1 2 2 2 2 Protein kinase domain SAM_2 PF07647.17 EFA84536.1 - 0.04 14.0 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pmp3 PF01679.17 EFA84537.1 - 1.2e-19 70.3 11.9 1.3e-19 70.1 11.9 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF1056 PF06341.11 EFA84537.1 - 0.03 14.6 0.7 0.039 14.3 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1056) Adap_comp_sub PF00928.21 EFA84539.1 - 3.3e-54 184.0 10.7 3.8e-54 183.8 10.7 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Ank_2 PF12796.7 EFA84540.1 - 1.8e-19 70.1 1.7 2.7e-05 24.7 0.0 6.0 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84540.1 - 3.6e-19 68.8 5.7 0.011 16.3 0.0 8.1 8 1 1 9 9 9 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84540.1 - 6.8e-12 45.4 4.5 0.042 14.2 0.0 9.1 5 2 7 12 12 12 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84540.1 - 1.3e-10 40.5 2.2 3.7 8.4 0.0 8.0 8 1 1 9 9 9 3 Ankyrin repeat DUF2591 PF10765.9 EFA84540.1 - 0.0021 18.3 0.1 1.5 9.1 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2591) DUF5049 PF16468.5 EFA84540.1 - 0.0056 16.5 0.5 1.6 8.7 0.1 4.3 5 1 1 6 6 6 1 Domain of unknown function (DUF5049) Ndc80_HEC PF03801.13 EFA84540.1 - 0.33 10.6 4.6 2.6 7.7 0.1 3.9 3 1 0 4 4 4 0 HEC/Ndc80p family F-box_5 PF18511.1 EFA84541.1 - 0.00036 20.0 0.0 0.00079 18.9 0.0 1.5 1 0 0 1 1 1 1 F-box GBP_PSP PF02425.15 EFA84541.1 - 0.11 12.2 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Paralytic/GBP/PSP peptide BTB PF00651.31 EFA84542.1 - 2.8e-19 69.4 0.2 1.1e-17 64.3 0.0 2.9 2 1 1 3 3 3 1 BTB/POZ domain Arteri_nsp7a PF16749.5 EFA84542.1 - 0.13 12.5 0.1 0.42 10.8 0.1 1.8 2 0 0 2 2 2 0 Arterivirus nonstructural protein 7 alpha DUF1015 PF06245.11 EFA84543.1 - 0.049 12.5 0.1 0.055 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) SPC12 PF06645.13 EFA84544.1 - 0.026 14.6 0.7 0.05 13.7 0.7 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Flp1_like PF16982.5 EFA84544.1 - 0.046 13.1 0.2 0.092 12.2 0.2 1.5 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain EamA PF00892.20 EFA84545.1 - 5.2e-05 23.4 31.6 0.015 15.5 21.9 2.3 1 1 1 2 2 2 2 EamA-like transporter family TPT PF03151.16 EFA84545.1 - 6.2e-05 22.5 9.7 6.2e-05 22.5 9.7 2.2 1 1 1 2 2 2 1 Triose-phosphate Transporter family VIT1 PF01988.19 EFA84545.1 - 4.2 7.2 10.3 0.99 9.2 6.6 1.8 1 1 1 2 2 2 0 VIT family Kinesin PF00225.23 EFA84546.1 - 1.5e-94 316.7 3.5 1.5e-94 316.7 3.5 2.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFA84546.1 - 1.2e-18 67.4 0.2 1.5e-17 63.9 0.1 3.1 2 0 0 2 2 2 1 Microtubule binding Ras PF00071.22 EFA84546.1 - 8.9e-07 28.6 0.1 6e-05 22.7 0.0 3.2 1 1 1 2 2 2 1 Ras family VWA_2 PF13519.6 EFA84546.1 - 1.3e-06 29.0 0.0 1.3e-06 29.0 0.0 3.2 4 0 0 4 4 3 1 von Willebrand factor type A domain ubiquitin PF00240.23 EFA84546.1 - 1.9e-06 27.5 0.5 1.1e-05 25.1 0.0 2.7 2 0 0 2 2 2 1 Ubiquitin family SAM_1 PF00536.30 EFA84546.1 - 5.7e-06 26.7 0.5 1.4e-05 25.4 0.5 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Roc PF08477.13 EFA84546.1 - 0.00073 19.7 0.2 0.93 9.7 0.0 4.2 4 0 0 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase OKR_DC_1_N PF03709.15 EFA84546.1 - 0.003 17.8 2.2 0.018 15.3 0.0 3.2 4 0 0 4 4 4 1 Orn/Lys/Arg decarboxylase, N-terminal domain SAM_2 PF07647.17 EFA84546.1 - 0.0094 16.0 0.5 0.028 14.5 0.5 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA_24 PF13479.6 EFA84546.1 - 0.016 14.9 0.0 0.72 9.5 0.0 3.0 2 0 0 2 2 2 0 AAA domain RelB_transactiv PF16181.5 EFA84546.1 - 0.072 13.3 0.3 0.17 12.2 0.3 1.5 1 0 0 1 1 1 0 RelB transactivation domain hDGE_amylase PF14701.6 EFA84547.1 - 1.2e-159 532.2 0.1 1.9e-159 531.5 0.1 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EFA84547.1 - 1.9e-79 267.4 2.7 4.1e-72 243.2 0.2 2.6 2 1 1 3 3 3 2 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EFA84547.1 - 2.7e-66 223.8 0.0 4.5e-66 223.1 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EFA84547.1 - 5.6e-10 39.2 0.0 1.3e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme MTCP1 PF08991.10 EFA84548.1 - 0.0011 19.2 2.2 0.0015 18.7 2.2 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EFA84548.1 - 0.23 11.6 4.3 0.38 10.9 4.3 1.4 1 0 0 1 1 1 0 CHCH domain COX6B PF02297.17 EFA84548.1 - 0.63 10.3 6.0 3 8.1 6.2 1.8 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb E1-E2_ATPase PF00122.20 EFA84549.1 - 7.8e-51 172.2 2.0 7.8e-51 172.2 2.0 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFA84549.1 - 3.8e-18 66.5 0.0 8.6e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFA84549.1 - 5e-13 48.5 0.0 9.9e-13 47.6 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA84549.1 - 0.002 17.9 3.2 0.0023 17.7 0.2 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA84549.1 - 0.0023 18.0 0.0 0.0062 16.6 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) HAD PF12710.7 EFA84549.1 - 0.032 14.6 0.0 0.079 13.4 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TCTP PF00838.17 EFA84550.1 - 5.4e-53 179.7 4.8 5.4e-53 179.7 4.8 2.3 2 1 1 3 3 3 1 Translationally controlled tumour protein tRNA_int_endo PF01974.17 EFA84550.1 - 6.1e-19 67.9 0.0 1.6e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EFA84550.1 - 2.5e-06 27.0 0.1 7.3e-05 22.4 0.0 2.4 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain VWA_2 PF13519.6 EFA84551.1 - 3.4e-08 34.1 0.0 2e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFA84551.1 - 6.5e-07 29.8 0.0 1.8e-06 28.4 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain ubiquitin PF00240.23 EFA84551.1 - 1.3e-06 28.0 0.1 4e-06 26.5 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin family DUF2184 PF09950.9 EFA84551.1 - 0.005 16.3 1.3 0.0088 15.5 1.3 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2184) DUF2119 PF09892.9 EFA84552.1 - 0.011 15.1 0.4 0.042 13.2 0.4 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) Moulting_cycle PF04870.16 EFA84552.1 - 0.037 13.3 0.1 0.043 13.1 0.1 1.1 1 0 0 1 1 1 0 Moulting cycle Peptidase_M24 PF00557.24 EFA84553.1 - 1e-48 165.8 0.1 1.3e-48 165.5 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EFA84553.1 - 1.2e-15 57.5 7.8 3e-15 56.3 7.8 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EFA84553.1 - 0.00029 20.9 4.5 0.00062 19.8 4.5 1.6 1 0 0 1 1 1 1 MYND finger zf-FCS PF06467.14 EFA84553.1 - 0.065 13.2 3.2 0.29 11.1 3.2 2.2 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DUF2116 PF09889.9 EFA84553.1 - 0.11 12.5 1.2 0.25 11.4 1.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zf-HIT PF04438.16 EFA84553.1 - 1.1 9.2 5.0 2.4 8.1 5.0 1.6 1 0 0 1 1 1 0 HIT zinc finger F-box PF00646.33 EFA84555.1 - 0.02 14.8 0.8 0.057 13.3 0.8 1.8 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFA84555.1 - 0.055 13.4 0.3 0.15 11.9 0.3 1.7 1 0 0 1 1 1 0 F-box-like Fea1 PF07692.11 EFA84555.1 - 0.54 9.2 2.4 2.5 7.1 0.7 2.1 2 0 0 2 2 2 0 Low iron-inducible periplasmic protein SUIM_assoc PF16619.5 EFA84556.1 - 0.0083 16.2 10.2 0.0083 16.2 10.2 1.1 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 MscS_TM PF12794.7 EFA84556.1 - 2.1 7.1 4.4 2.1 7.1 4.4 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CBFD_NFYB_HMF PF00808.23 EFA84557.1 - 9.5e-27 93.1 1.6 9.5e-27 93.1 1.6 1.6 2 0 0 2 2 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFA84557.1 - 0.00036 20.9 0.1 0.00036 20.9 0.1 3.1 2 1 1 3 3 2 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 EFA84557.1 - 0.00076 19.6 38.5 0.00089 19.4 38.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 EFA84557.1 - 0.004 16.2 47.3 0.0073 15.3 47.3 1.5 1 0 0 1 1 1 1 Transcriptional activator LAG-3 FAM222A PF15258.6 EFA84557.1 - 0.0094 15.1 30.1 0.012 14.8 30.1 1.1 1 0 0 1 1 1 1 Protein family of FAM222A PAT1 PF09770.9 EFA84557.1 - 0.022 13.0 30.0 0.026 12.8 30.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Bromo_TP PF07524.13 EFA84557.1 - 0.025 14.6 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated TFIID-18kDa PF02269.16 EFA84557.1 - 0.042 13.9 1.9 0.055 13.5 0.0 2.2 2 1 1 3 3 3 0 Transcription initiation factor IID, 18kD subunit GREB1 PF15782.5 EFA84557.1 - 0.23 8.6 22.5 0.26 8.4 22.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PBP_sp32 PF07222.12 EFA84557.1 - 0.31 10.5 18.4 0.48 9.8 18.4 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4551 PF15087.6 EFA84557.1 - 0.45 9.3 21.2 0.57 9.0 21.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hid1 PF12722.7 EFA84557.1 - 1.7 6.7 22.3 2.3 6.3 22.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 EFA84557.1 - 3.5 6.2 17.3 4.1 6.0 17.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SelP_N PF04592.14 EFA84557.1 - 3.7 6.9 23.5 6.5 6.1 23.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ubiquitin PF00240.23 EFA84558.1 - 1e-13 50.8 0.2 2.3e-13 49.7 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin family DUF2407_C PF13373.6 EFA84558.1 - 4.4e-06 26.9 0.7 1.1e-05 25.6 0.1 1.9 2 0 0 2 2 2 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EFA84558.1 - 1.3e-05 25.7 0.7 3.3e-05 24.4 0.4 1.7 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EFA84558.1 - 5.5e-05 22.9 0.4 0.00011 21.9 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFA84558.1 - 0.0037 17.4 0.1 0.0077 16.3 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFA84558.1 - 0.044 14.1 1.1 0.088 13.2 0.5 1.8 2 1 0 2 2 2 0 Ubiquitin-like domain LicD PF04991.13 EFA84558.1 - 0.16 12.1 2.1 0.26 11.4 2.1 1.3 1 0 0 1 1 1 0 LicD family Ank_4 PF13637.6 EFA84559.1 - 3.3e-33 113.6 18.1 5.1e-05 23.7 0.1 10.5 7 3 2 10 10 10 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84559.1 - 9e-31 106.3 13.6 9.5e-06 26.1 0.3 6.9 4 2 2 6 6 6 6 Ankyrin repeats (3 copies) KxDL PF10241.9 EFA84559.1 - 8.6e-21 74.0 5.7 2.2e-20 72.7 4.9 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein Ank_5 PF13857.6 EFA84559.1 - 1.3e-17 63.6 15.1 1.7 9.1 0.1 13.8 8 5 7 16 16 16 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84559.1 - 4.1e-17 60.5 11.8 7.2 7.5 0.0 15.0 16 0 0 16 16 16 1 Ankyrin repeat DUF3447 PF11929.8 EFA84559.1 - 0.0025 17.7 0.0 0.033 14.2 0.0 8.0 4 2 4 8 8 8 2 Domain of unknown function (DUF3447) Helicase_PWI PF18149.1 EFA84559.1 - 0.017 15.3 12.4 7.4 6.8 0.1 6.2 5 2 3 8 8 8 0 N-terminal helicase PWI domain DUF3624 PF12292.8 EFA84559.1 - 0.19 12.2 0.8 7.8 7.0 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) SUIM_assoc PF16619.5 EFA84559.1 - 3.9 7.6 10.9 9.9 6.3 10.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CBM49 PF09478.10 EFA84560.1 - 8e-15 54.9 6.2 2.7e-14 53.3 6.2 1.9 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 FG-GAP PF01839.23 EFA84561.1 - 1.6e-22 79.3 13.5 4.5e-07 29.9 1.3 4.9 4 0 0 4 4 4 4 FG-GAP repeat Zn_dep_PLPC PF00882.18 EFA84561.1 - 2.3e-20 73.4 0.9 3.6e-20 72.7 0.9 1.3 1 0 0 1 1 1 1 Zinc dependent phospholipase C VCBS PF13517.6 EFA84561.1 - 3.4e-11 43.6 19.6 1.2e-05 25.8 2.6 4.3 4 1 1 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 EFA84561.1 - 0.0011 19.2 11.6 8.9 6.7 0.0 5.9 5 0 0 5 5 5 1 FG-GAP repeat PliI PF16743.5 EFA84561.1 - 0.096 12.4 0.1 4.7 7.0 0.1 3.1 4 0 0 4 4 4 0 Periplasmic lysozyme inhibitor of I-type lysozyme Ank_2 PF12796.7 EFA84562.1 - 3.5e-19 69.2 2.2 1.8e-05 25.3 0.0 5.4 3 3 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84562.1 - 2.5e-15 56.6 6.8 0.0062 17.1 0.0 8.9 4 2 7 11 11 11 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84562.1 - 1.2e-14 54.2 2.6 0.16 12.3 0.0 8.4 5 3 4 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84562.1 - 1.1e-13 50.0 0.3 1.9 9.3 0.0 10.1 10 0 0 10 10 10 3 Ankyrin repeat DUF5049 PF16468.5 EFA84562.1 - 0.078 12.9 3.8 48 4.0 0.0 5.1 7 1 0 7 7 7 0 Domain of unknown function (DUF5049) DUF249 PF03158.13 EFA84562.1 - 0.1 12.3 12.1 1.8 8.2 0.1 5.8 5 2 1 6 6 6 0 Multigene family 530 protein Ank_2 PF12796.7 EFA84563.1 - 3.1e-15 56.5 0.1 0.00012 22.6 0.0 5.6 3 3 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84563.1 - 1.2e-14 54.5 2.4 0.03 14.9 0.0 7.3 6 2 2 8 8 8 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84563.1 - 1.4e-12 47.6 0.0 0.34 11.3 0.0 6.9 7 0 0 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84563.1 - 1.5e-08 34.2 0.1 7.7 7.4 0.0 7.6 8 0 0 8 8 8 1 Ankyrin repeat DUF249 PF03158.13 EFA84563.1 - 0.022 14.5 7.5 0.91 9.2 0.1 4.7 3 1 1 6 6 6 0 Multigene family 530 protein DUF5049 PF16468.5 EFA84563.1 - 0.022 14.6 1.2 7.5 6.5 0.1 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF5049) CBM49 PF09478.10 EFA84564.1 - 3.7e-15 56.0 6.7 1.1e-14 54.5 6.7 1.8 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Uma2 PF05685.12 EFA84565.1 - 0.0051 16.4 0.0 0.0081 15.7 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease DnaJ PF00226.31 EFA84566.1 - 2e-23 82.2 2.8 5.4e-23 80.9 2.8 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_6 PF13174.6 EFA84566.1 - 0.037 14.7 0.1 0.12 13.0 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA84566.1 - 0.048 13.9 0.3 0.31 11.4 0.0 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Roughex PF06020.11 EFA84566.1 - 0.82 8.7 16.6 1.5 7.8 16.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DUF1878 PF08963.10 EFA84566.1 - 2.8 8.5 7.2 1.5 9.3 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1878) Myc_N PF01056.18 EFA84566.1 - 7.8 6.3 25.4 7.3 6.4 8.9 2.5 1 1 1 2 2 2 0 Myc amino-terminal region DIOX_N PF14226.6 EFA84567.1 - 9.4e-05 23.2 0.0 0.00019 22.2 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFA84567.1 - 0.0003 21.2 0.0 0.00046 20.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Myotub-related PF06602.14 EFA84568.1 - 1.3e-132 442.0 0.9 1.3e-132 442.0 0.9 1.7 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain FERM_f0 PF16511.5 EFA84568.1 - 1.1e-10 41.6 4.3 0.0072 16.6 0.0 7.3 7 1 0 7 7 7 3 N-terminal or F0 domain of Talin-head FERM GRAM PF02893.20 EFA84568.1 - 0.00014 21.7 0.1 0.00073 19.4 0.1 2.2 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.20 EFA84568.1 - 0.005 16.6 0.0 0.022 14.5 0.0 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFA84568.1 - 0.028 14.4 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Pkinase PF00069.25 EFA84569.1 - 2.1e-38 132.2 0.0 4.6e-19 68.8 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84569.1 - 2.8e-23 82.5 0.0 1.1e-10 41.2 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase RNA_pol_Rpc4 PF05132.14 EFA84569.1 - 0.28 11.6 5.3 0.58 10.6 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Hamartin PF04388.12 EFA84569.1 - 1.2 7.7 20.5 1.6 7.3 20.5 1.1 1 0 0 1 1 1 0 Hamartin protein Methyltransf_23 PF13489.6 EFA84570.1 - 8e-17 61.6 0.0 1.2e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA84570.1 - 4.3e-16 59.3 0.1 8.9e-16 58.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84570.1 - 1.9e-12 47.8 1.1 2.4e-12 47.4 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84570.1 - 6.3e-12 46.0 0.0 1.2e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA84570.1 - 6.3e-11 42.3 0.0 9.9e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFA84570.1 - 5.7e-08 32.4 0.0 8.9e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EFA84570.1 - 2.1e-05 24.0 0.1 2.1e-05 24.0 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EFA84570.1 - 3.1e-05 23.4 0.0 4.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 EFA84570.1 - 0.00014 21.3 1.3 0.00023 20.7 0.1 1.8 2 0 0 2 2 2 1 Tellurite resistance protein TehB NodS PF05401.11 EFA84570.1 - 0.00023 20.9 0.0 0.00034 20.3 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 EFA84570.1 - 0.00042 20.3 0.2 0.00075 19.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFA84570.1 - 0.0022 17.5 0.1 0.0047 16.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_PK PF05891.12 EFA84570.1 - 0.0048 16.4 0.0 0.0069 15.9 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase GidB PF02527.15 EFA84570.1 - 0.0094 15.3 0.6 0.65 9.3 0.0 2.4 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G DUF5101 PF17031.5 EFA84570.1 - 0.011 15.8 1.2 0.021 14.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) JmjC PF02373.22 EFA84572.1 - 6.4e-15 55.6 0.0 4.2e-14 52.9 0.0 2.5 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 EFA84572.1 - 8.5e-15 55.1 0.1 4.3e-14 52.8 0.1 2.1 1 1 0 1 1 1 1 Cupin-like domain F-box PF00646.33 EFA84572.1 - 0.0033 17.2 1.3 0.0067 16.3 0.1 2.2 2 0 0 2 2 2 1 F-box domain APH PF01636.23 EFA84572.1 - 0.0038 17.2 0.0 2.3 8.1 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family F-box-like PF12937.7 EFA84572.1 - 0.016 15.1 0.0 0.054 13.4 0.0 1.9 1 0 0 1 1 1 0 F-box-like TilS_C PF11734.8 EFA84572.1 - 0.12 11.9 0.4 2.5 7.6 0.0 2.6 2 0 0 2 2 2 0 TilS substrate C-terminal domain AvrPto PF11592.8 EFA84573.1 - 0.052 13.6 0.1 14 5.7 0.0 2.3 2 0 0 2 2 2 0 Central core of the bacterial effector protein AvrPto U-box PF04564.15 EFA84573.1 - 0.1 12.8 0.1 3.8 7.8 0.0 2.2 2 0 0 2 2 2 0 U-box domain tRNA-synt_2 PF00152.20 EFA84574.1 - 1.8e-75 254.0 0.0 2.8e-75 253.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFA84574.1 - 5.7e-08 32.6 0.1 1.2e-07 31.6 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFA84574.1 - 1e-05 25.2 0.0 0.014 14.9 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) GATA PF00320.27 EFA84575.1 - 3.8e-11 42.4 3.8 1.4e-10 40.6 3.8 2.0 1 0 0 1 1 1 1 GATA zinc finger Acetyltransf_3 PF13302.7 EFA84576.1 - 6.2e-15 56.1 0.0 6.9e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA84576.1 - 7.7e-06 26.1 0.0 0.00015 22.0 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFA84576.1 - 3.3e-05 23.8 0.0 0.075 13.0 0.0 2.4 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_4 PF13420.7 EFA84576.1 - 0.004 17.3 0.5 0.065 13.4 0.5 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA84576.1 - 0.0088 16.4 0.1 0.017 15.6 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA84576.1 - 0.012 15.6 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.6 EFA84576.1 - 0.08 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Ago_N_1 PF18351.1 EFA84576.1 - 0.13 12.7 2.0 2.4 8.7 0.4 2.4 1 1 1 2 2 2 0 Fungal Argonaute N-terminal domain Palm_thioest PF02089.15 EFA84577.1 - 4.1e-08 33.4 0.0 4.1e-08 33.4 0.0 3.0 2 1 0 2 2 2 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EFA84577.1 - 1.9e-06 27.8 0.0 1.9e-06 27.8 0.0 2.5 2 1 0 2 2 2 1 PGAP1-like protein GATA PF00320.27 EFA84577.1 - 7.9e-06 25.4 1.4 7.9e-06 25.4 1.4 2.1 2 0 0 2 2 2 1 GATA zinc finger DUF676 PF05057.14 EFA84577.1 - 6.4e-05 22.6 0.0 0.00016 21.3 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EFA84577.1 - 0.0011 18.3 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA84577.1 - 0.0019 18.8 0.0 0.0029 18.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA84577.1 - 0.0033 17.1 0.1 0.0033 17.1 0.1 2.6 2 2 1 3 3 3 1 alpha/beta hydrolase fold DBC1 PF14443.6 EFA84579.1 - 3.6e-40 136.8 1.8 4.3e-40 136.5 0.0 2.0 2 0 0 2 2 2 1 DBC1 Ank_2 PF12796.7 EFA84580.1 - 4.2e-22 78.5 0.5 5.7e-06 26.8 0.0 6.0 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84580.1 - 1.3e-18 67.1 6.5 3.5e-05 24.3 0.0 7.2 7 1 0 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84580.1 - 4.2e-12 45.1 5.3 1.5 9.7 0.1 9.7 9 1 1 10 10 10 2 Ankyrin repeat Ank_5 PF13857.6 EFA84580.1 - 1.2e-11 44.6 4.1 1.6 9.2 0.1 8.0 7 2 2 9 9 9 4 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA84580.1 - 0.0047 16.9 27.4 0.024 14.6 0.0 8.0 7 3 3 10 10 10 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA84580.1 - 0.099 13.1 0.1 1.6e+02 3.0 0.0 4.5 3 1 1 4 4 4 0 Ankyrin repeat Ribonuclease_3 PF00636.26 EFA84581.1 - 0.00026 21.6 0.0 0.00057 20.5 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease III domain AAA_35 PF14516.6 EFA84582.1 - 0.003 16.5 0.3 0.0082 15.0 0.1 1.8 2 0 0 2 2 2 1 AAA-like domain EspA PF03433.13 EFA84582.1 - 0.076 12.8 0.3 0.21 11.4 0.2 1.7 1 1 0 1 1 1 0 EspA-like secreted protein DUF2999 PF11212.8 EFA84582.1 - 0.16 12.2 1.8 14 6.1 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2999) Mad3_BUB1_I PF08311.12 EFA84583.1 - 1.5e-41 141.3 3.5 1.5e-41 141.3 3.5 2.1 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EFA84583.1 - 0.00016 21.2 0.0 0.00032 20.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_I_2 PF17014.5 EFA84583.1 - 0.014 15.5 1.4 0.044 13.9 1.4 1.8 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein Kinase-like PF14531.6 EFA84583.1 - 0.059 12.7 0.1 0.099 11.9 0.1 1.3 1 0 0 1 1 1 0 Kinase-like DUF565 PF04483.12 EFA84583.1 - 0.076 13.6 0.1 0.19 12.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF565) ATP12 PF07542.11 EFA84584.1 - 3.7e-28 98.2 0.0 6e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Adaptin_N PF01602.20 EFA84585.1 - 2.3e-140 468.6 12.0 3.2e-140 468.2 12.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EFA84585.1 - 8.4e-23 80.8 0.9 8.4e-23 80.8 0.9 2.9 3 1 0 3 3 3 1 Adaptin C-terminal domain Cnd1 PF12717.7 EFA84585.1 - 5.7e-09 36.2 9.6 2.6e-05 24.3 0.1 3.5 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFA84585.1 - 1.7e-05 24.7 0.5 1 9.8 0.1 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EFA84585.1 - 6.1e-05 23.3 0.5 1.3 9.4 0.0 3.9 4 0 0 4 4 4 2 HEAT repeats TIP120 PF08623.10 EFA84585.1 - 0.0015 18.3 5.7 0.25 11.1 0.3 2.9 3 0 0 3 3 3 2 TATA-binding protein interacting (TIP20) Cohesin_HEAT PF12765.7 EFA84585.1 - 0.037 14.3 0.7 0.19 12.0 0.1 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Vac14_Fab1_bd PF12755.7 EFA84585.1 - 0.13 12.9 2.0 11 6.7 0.1 3.5 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region eIF3_subunit PF08597.10 EFA84585.1 - 0.24 11.3 0.6 0.49 10.3 0.6 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Ndc1_Nup PF09531.10 EFA84585.1 - 0.56 8.8 7.0 1.1 7.9 7.0 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_C1 PF00112.23 EFA84586.1 - 1.5e-51 175.6 3.5 2e-51 175.2 3.5 1.2 1 0 0 1 1 1 1 Papain family cysteine protease CS PF04969.16 EFA84587.1 - 1.9e-08 35.2 0.0 3e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 CS domain RRN3 PF05327.11 EFA84587.1 - 1.4 7.3 3.6 1.8 7.0 3.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Adaptin_binding PF10199.9 EFA84588.1 - 3e-17 63.3 7.2 7.1e-17 62.1 7.2 1.6 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Ras PF00071.22 EFA84588.1 - 0.0031 17.1 0.6 0.0093 15.6 0.2 2.0 2 0 0 2 2 2 1 Ras family PTS_EIIA_2 PF00359.22 EFA84588.1 - 0.0038 17.1 0.4 1 9.3 0.1 2.4 2 0 0 2 2 2 2 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 NADH-u_ox-rdase PF10785.9 EFA84589.1 - 6.3e-23 81.3 0.0 1.5e-22 80.1 0.0 1.6 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF5083 PF16890.5 EFA84589.1 - 0.0019 17.9 0.3 0.0024 17.6 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5083) zf-CCCH_2 PF14608.6 EFA84590.1 - 9e-26 89.4 77.8 4.1e-05 23.9 2.1 7.4 7 0 0 7 7 7 7 RNA-binding, Nab2-type zinc finger PWI PF01480.17 EFA84590.1 - 3.2e-08 33.8 0.5 5.6e-08 33.0 0.5 1.3 1 0 0 1 1 1 1 PWI domain zf-CCCH_4 PF18044.1 EFA84590.1 - 0.00027 20.7 7.8 0.0009 19.0 1.9 8.5 8 2 0 8 8 8 4 CCCH-type zinc finger zf-CCCH PF00642.24 EFA84590.1 - 0.0003 20.6 60.3 0.031 14.2 0.3 9.8 9 2 0 9 9 9 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nab2p_Zf1 PF18260.1 EFA84590.1 - 0.0098 15.8 1.4 0.0098 15.8 1.4 4.7 5 0 0 5 5 5 2 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf_CCCH_4 PF18345.1 EFA84590.1 - 0.024 14.7 0.3 0.024 14.7 0.3 10.8 10 2 2 12 12 12 0 Zinc finger domain Macoilin PF09726.9 EFA84590.1 - 0.94 8.0 14.1 1.3 7.5 14.1 1.1 1 0 0 1 1 1 0 Macoilin family F-box-like PF12937.7 EFA84591.1 - 2.2e-07 30.7 0.6 7.7e-07 28.9 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA84591.1 - 0.00014 21.6 0.6 0.00053 19.8 0.2 2.3 2 0 0 2 2 2 1 F-box domain Arm PF00514.23 EFA84591.1 - 0.002 18.1 0.2 0.26 11.4 0.0 3.0 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat NopRA1 PF16201.5 EFA84591.1 - 0.031 13.9 0.9 0.091 12.3 0.3 2.0 1 1 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 Ist1 PF03398.14 EFA84591.1 - 0.059 13.3 0.1 0.22 11.4 0.0 1.9 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Elongin_A PF06881.11 EFA84591.1 - 0.082 13.4 0.3 0.37 11.3 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Peptidase_M1_N PF17900.1 EFA84594.1 - 0.00022 21.5 0.0 0.00022 21.5 0.0 2.4 3 0 0 3 3 3 1 Peptidase M1 N-terminal domain IP_trans PF02121.18 EFA84595.1 - 1.3e-84 283.6 5.6 4.8e-65 219.6 0.4 2.0 1 1 1 2 2 2 2 Phosphatidylinositol transfer protein MaoC_dehydratas PF01575.19 EFA84596.1 - 7.9e-21 73.9 0.0 9.5e-21 73.6 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EFA84596.1 - 1.2e-07 32.0 0.0 1.5e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.22 EFA84596.1 - 0.0063 16.8 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 Thioesterase superfamily AAA_2 PF07724.14 EFA84597.1 - 1.7e-39 135.7 4.2 4.6e-32 111.5 0.3 3.2 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFA84597.1 - 8e-14 52.2 0.1 1.1e-05 25.8 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFA84597.1 - 2.6e-07 30.7 0.2 1.5e-05 25.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 EFA84597.1 - 3e-07 30.4 1.9 7.8e-07 29.1 0.4 2.5 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein Mg_chelatase PF01078.21 EFA84597.1 - 3.7e-05 23.2 0.2 0.0021 17.4 0.2 3.0 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EFA84597.1 - 7.5e-05 23.2 0.0 0.0016 18.8 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFA84597.1 - 0.00028 21.2 0.2 0.0056 17.0 0.0 2.8 1 1 1 2 2 2 1 AAA domain MCM PF00493.23 EFA84597.1 - 0.00028 20.0 0.0 0.0061 15.7 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain Sigma54_activat PF00158.26 EFA84597.1 - 0.00068 19.4 0.0 0.042 13.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 EFA84597.1 - 0.0019 18.3 1.0 0.15 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA84597.1 - 0.002 18.7 0.4 0.022 15.3 0.0 2.7 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 EFA84597.1 - 0.0021 17.8 0.1 0.059 13.1 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain SPATA19 PF15212.6 EFA84597.1 - 0.0026 18.0 2.0 0.0048 17.1 0.4 2.4 2 1 0 2 2 2 1 Spermatogenesis-associated protein 19, mitochondrial Zeta_toxin PF06414.12 EFA84597.1 - 0.007 15.7 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin RNA_helicase PF00910.22 EFA84597.1 - 0.047 14.1 3.3 0.45 10.9 0.0 3.5 3 1 0 3 3 3 0 RNA helicase IstB_IS21 PF01695.17 EFA84597.1 - 0.057 13.2 0.0 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Leg1 PF05612.12 EFA84598.1 - 1.4e-61 208.5 0.1 1.8e-61 208.1 0.1 1.0 1 0 0 1 1 1 1 Leg1 Myb_DNA-binding PF00249.31 EFA84599.1 - 3.1e-10 40.1 0.0 6.4e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA84599.1 - 2e-05 24.8 0.1 6.4e-05 23.1 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFA84599.1 - 0.00025 20.9 0.1 0.0014 18.5 0.1 2.3 1 0 0 1 1 1 1 Myb DNA-binding like DUF3452 PF11934.8 EFA84599.1 - 0.0093 15.5 0.4 0.0093 15.5 0.4 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3452) Y_phosphatase2 PF03162.13 EFA84600.1 - 1.7e-56 190.3 0.0 1.9e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFA84600.1 - 0.026 14.5 0.0 0.063 13.2 0.0 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family MMR_HSR1 PF01926.23 EFA84601.1 - 4.9e-07 29.8 0.1 1.3e-06 28.5 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA84601.1 - 6.4e-05 22.5 0.4 0.00011 21.7 0.4 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Desmo_N PF06771.11 EFA84601.1 - 0.01 16.2 0.4 0.033 14.5 0.4 1.9 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus HHH_7 PF14635.6 EFA84601.1 - 0.031 14.6 0.2 0.55 10.6 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif AAA_24 PF13479.6 EFA84601.1 - 0.038 13.7 1.1 0.21 11.3 0.3 2.4 2 1 1 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA84601.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EFA84601.1 - 1.9 9.0 7.4 13 6.3 7.4 2.5 1 1 0 1 1 1 0 ABC transporter ABC_membrane PF00664.23 EFA84602.1 - 2e-53 181.8 36.1 6.8e-31 107.9 14.6 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFA84602.1 - 2.7e-45 154.2 7.5 8.1e-27 94.4 0.1 3.8 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EFA84602.1 - 1.7e-14 53.8 10.1 2.1e-05 24.1 2.9 4.5 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFA84602.1 - 5.6e-07 29.6 0.5 0.021 14.8 0.2 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_29 PF13555.6 EFA84602.1 - 0.00058 19.5 3.1 0.15 11.8 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EFA84602.1 - 0.001 19.0 7.4 0.94 9.2 0.2 4.1 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFA84602.1 - 0.0031 17.6 10.3 0.11 12.6 0.1 4.3 5 0 0 5 5 4 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EFA84602.1 - 0.019 15.3 0.1 11 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EFA84602.1 - 0.037 14.3 0.1 18 5.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 EFA84602.1 - 0.1 12.2 1.0 1.5 8.4 0.0 3.3 4 0 0 4 4 4 0 AAA domain cobW PF02492.19 EFA84602.1 - 0.18 11.4 3.2 1.8 8.1 0.2 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain XhlA PF10779.9 EFA84602.1 - 0.22 11.7 5.2 0.092 13.0 0.9 2.7 2 0 0 2 2 2 0 Haemolysin XhlA NACHT PF05729.12 EFA84602.1 - 0.36 10.7 1.6 8 6.4 0.1 2.9 3 0 0 3 3 3 0 NACHT domain AAA_30 PF13604.6 EFA84602.1 - 0.47 10.2 1.5 21 4.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain IZUMO PF15005.6 EFA84602.1 - 0.49 10.9 5.7 1.3 9.5 5.7 1.7 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DUF87 PF01935.17 EFA84602.1 - 5.2 7.1 12.0 6.6 6.8 0.1 4.0 3 0 0 3 3 3 0 Helicase HerA, central domain PPP4R2 PF09184.11 EFA84603.1 - 3.1e-23 82.8 10.8 4.1e-23 82.4 10.8 1.3 1 0 0 1 1 1 1 PPP4R2 Ank_2 PF12796.7 EFA84604.1 - 5.9e-36 122.9 5.7 1.2e-08 35.4 0.2 5.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84604.1 - 1.3e-34 118.1 1.5 2.4e-06 28.0 0.0 7.4 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84604.1 - 3.5e-25 87.7 2.1 0.0043 17.3 0.0 9.8 1 1 10 11 11 11 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84604.1 - 1.4e-19 68.1 0.9 1.8 9.4 0.0 10.7 5 3 4 10 10 10 4 Ankyrin repeat DUF3447 PF11929.8 EFA84604.1 - 2.3e-10 40.3 4.8 0.00076 19.4 0.4 5.3 1 1 4 5 5 5 2 Domain of unknown function (DUF3447) DUF5049 PF16468.5 EFA84604.1 - 1.3e-05 25.0 0.8 3.9 7.5 0.0 6.4 5 2 3 8 8 8 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA84604.1 - 0.0015 18.9 0.1 89 3.8 0.0 6.5 5 3 1 6 6 6 0 Ankyrin repeat RNase_P_p30 PF01876.16 EFA84604.1 - 0.12 11.8 0.0 24 4.3 0.0 3.4 3 1 1 4 4 4 0 RNase P subunit p30 Pkinase PF00069.25 EFA84605.1 - 1.3e-68 231.3 0.0 1.7e-68 230.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84605.1 - 1.1e-51 175.6 0.0 1.5e-51 175.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA84605.1 - 1.6e-06 27.1 0.0 2.5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFA84605.1 - 3e-05 23.5 0.0 6.8e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFA84605.1 - 0.00055 19.0 0.1 0.00076 18.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFA84605.1 - 0.0092 15.9 0.0 3.4 7.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFA84605.1 - 0.068 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ndc80_HEC PF03801.13 EFA84606.1 - 2.4e-41 140.9 0.6 2.4e-41 140.9 0.6 3.7 3 1 1 4 4 4 1 HEC/Ndc80p family Pilin_N PF07790.11 EFA84606.1 - 1.2 10.1 3.2 4.5 8.3 0.0 2.9 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal 7TM_transglut PF14402.6 EFA84606.1 - 4.6 6.6 5.1 11 5.4 5.1 1.6 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase DpnI_C PF17726.1 EFA84609.1 - 3.7 7.7 7.7 5.6 7.2 0.9 2.8 2 0 0 2 2 2 0 Dam-replacing HTH domain Complex1_LYR PF05347.15 EFA84612.1 - 0.032 14.3 0.6 0.057 13.5 0.6 1.4 1 0 0 1 1 1 0 Complex 1 protein (LYR family) Methyltransf_2 PF00891.18 EFA84613.1 - 7.5e-36 123.4 0.0 9.7e-36 123.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EFA84613.1 - 2e-07 30.9 0.0 1.7e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 Dimerisation domain HTH_44 PF14641.6 EFA84613.1 - 0.1 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 PA26 PF04636.13 EFA84614.1 - 3.6e-114 382.1 0.2 7.5e-93 311.8 0.2 2.2 1 1 1 2 2 2 2 PA26 p53-induced protein (sestrin) Lin-8 PF03353.15 EFA84614.1 - 0.46 10.0 4.5 0.3 10.6 0.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PIN_12 PF16289.5 EFA84615.1 - 0.33 11.4 18.1 0.12 12.9 4.2 2.2 2 0 0 2 2 2 0 PIN domain MRP-S26 PF14943.6 EFA84615.1 - 3.7 7.4 26.9 0.69 9.8 8.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 HDA2-3 PF11496.8 EFA84615.1 - 9 5.4 16.5 2.3 7.3 7.8 2.2 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Ammonium_transp PF00909.21 EFA84616.1 - 5.5e-99 331.6 14.9 6.4e-99 331.3 14.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family CNOT11 PF10155.9 EFA84617.1 - 1.8e-45 154.1 6.0 2.5e-45 153.7 4.9 1.9 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 11 SUIM_assoc PF16619.5 EFA84617.1 - 0.00022 21.2 10.1 0.00022 21.2 10.1 3.5 5 0 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 EFA84617.1 - 0.0009 18.9 10.1 0.0009 18.9 10.1 3.3 2 1 0 2 2 2 1 Spt20 family TFIIA PF03153.13 EFA84617.1 - 0.0011 19.1 23.8 0.0014 18.7 23.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 EFA84617.1 - 0.0027 16.7 19.1 0.0044 15.9 2.9 2.2 2 0 0 2 2 2 2 Golgi-body localisation protein domain Zip PF02535.22 EFA84617.1 - 0.012 14.8 4.5 0.52 9.5 0.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter SpoIIIAH PF12685.7 EFA84617.1 - 0.018 14.9 20.1 0.35 10.7 3.6 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein Striatin PF08232.12 EFA84617.1 - 1.1 9.8 17.8 2.2 8.9 3.8 2.4 2 0 0 2 2 2 0 Striatin family Menin PF05053.13 EFA84617.1 - 3.4 5.9 17.6 0.26 9.6 1.9 2.1 2 0 0 2 2 2 0 Menin DUF908 PF06012.12 EFA84617.1 - 4 6.8 34.2 4.1 6.7 5.8 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) MAP70 PF07058.11 EFA84620.1 - 1.6 7.4 12.4 1.8 7.2 12.4 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 SdrD_B PF17210.3 EFA84622.1 - 7.9e-18 64.7 3.0 1.2e-09 38.3 0.8 2.9 2 0 0 2 2 2 2 SdrD B-like domain zf-C3HC4_3 PF13920.6 EFA84625.1 - 1.6e-08 34.3 12.4 2.3e-08 33.8 12.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA84625.1 - 0.0023 17.8 13.4 0.0038 17.0 13.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EFA84625.1 - 0.007 16.1 10.0 0.014 15.2 10.0 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EFA84625.1 - 0.011 15.7 12.7 0.042 13.8 13.0 1.8 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EFA84625.1 - 0.012 15.9 14.8 0.02 15.2 14.8 1.4 1 0 0 1 1 1 0 Ring finger domain SF-assemblin PF06705.11 EFA84625.1 - 0.082 12.2 1.3 0.12 11.7 1.3 1.2 1 0 0 1 1 1 0 SF-assemblin/beta giardin Remorin_C PF03763.13 EFA84625.1 - 0.2 11.5 0.3 0.34 10.8 0.3 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region zf-C3HC4_2 PF13923.6 EFA84625.1 - 0.24 11.3 13.3 0.44 10.4 13.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Dicty_REP PF05086.12 EFA84625.1 - 0.28 9.1 3.8 0.38 8.7 3.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-C3HC4 PF00097.25 EFA84625.1 - 0.31 11.0 14.8 0.53 10.2 14.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EFG_II PF14492.6 EFA84625.1 - 1.1 9.4 3.3 2.6 8.2 3.3 1.6 1 0 0 1 1 1 0 Elongation Factor G, domain II DHR-2 PF06920.13 EFA84626.1 - 2.2e-107 359.9 5.4 6.3e-107 358.4 5.4 1.8 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EFA84626.1 - 3.6e-30 105.2 3.2 1.4e-29 103.4 1.0 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 EFA84626.1 - 2e-06 27.0 1.2 1.3e-05 24.3 0.0 2.3 1 1 0 2 2 2 1 DOCK N-terminus SH3_2 PF07653.17 EFA84626.1 - 0.00017 21.2 0.1 0.033 13.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C2 PF00168.30 EFA84626.1 - 0.025 14.9 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 C2 domain SH3_1 PF00018.28 EFA84626.1 - 0.18 11.4 0.0 9.6 5.9 0.0 2.5 2 0 0 2 2 2 0 SH3 domain zf-B_box PF00643.24 EFA84627.1 - 2e-07 31.1 7.7 3.5e-07 30.3 7.7 1.4 1 0 0 1 1 1 1 B-box zinc finger FPP PF05911.11 EFA84627.1 - 0.0068 14.7 13.8 0.0083 14.4 13.8 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil DUF4081 PF13312.6 EFA84627.1 - 0.087 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) dCMP_cyt_deam_1 PF00383.23 EFA84629.1 - 8.2e-12 44.9 0.6 1.5e-11 44.0 0.2 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFA84629.1 - 6.3e-11 42.2 0.1 8.8e-11 41.7 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase LIM PF00412.22 EFA84630.1 - 3.8e-62 206.4 92.5 1.6e-14 53.8 5.0 8.9 7 1 1 8 8 8 8 LIM domain CH PF00307.31 EFA84630.1 - 2.1e-18 66.5 0.0 5.7e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain Ank_2 PF12796.7 EFA84631.1 - 1e-17 64.4 6.9 0.00028 21.4 0.0 6.5 4 1 2 7 7 7 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84631.1 - 4.1e-09 36.8 4.5 0.1 13.2 0.0 7.1 6 3 4 10 10 10 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84631.1 - 2.9e-05 24.3 1.1 0.067 13.5 0.0 5.5 6 0 0 6 6 6 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84631.1 - 0.095 13.3 10.8 1.1e+02 3.9 0.0 8.7 11 1 1 13 13 13 0 Ankyrin repeat Myosin_head PF00063.21 EFA84632.1 - 1.4e-219 730.8 0.0 4.3e-179 597.0 0.0 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 EFA84632.1 - 0.0013 19.1 0.0 0.0033 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFA84632.1 - 0.024 14.9 0.0 0.062 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 EFA84632.1 - 0.055 12.4 0.0 0.092 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.26 EFA84632.1 - 0.088 12.5 0.0 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFA84632.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 EFA84632.1 - 0.16 11.1 0.0 0.34 10.1 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 EFA84632.1 - 0.21 11.5 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase DUF1563 PF07599.11 EFA84632.1 - 0.22 11.6 2.3 16 5.7 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1563) Peptidase_C39_2 PF13529.6 EFA84633.1 - 1.1e-10 42.2 0.0 1.9e-10 41.4 0.0 1.4 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFA84633.1 - 0.0011 19.0 0.0 0.0012 18.8 0.0 1.3 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Guanylate_cyc_2 PF09778.9 EFA84633.1 - 0.0014 18.0 0.1 0.015 14.7 0.1 2.0 1 1 1 2 2 2 1 Guanylylate cyclase Gar1 PF04410.14 EFA84634.1 - 7.3e-31 107.0 0.1 9.2e-31 106.7 0.1 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Ank_2 PF12796.7 EFA84635.1 - 7.6e-14 52.1 2.5 0.012 16.2 0.1 6.1 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84635.1 - 1.6e-12 47.6 7.2 0.19 12.3 0.0 9.4 6 4 1 8 8 8 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84635.1 - 1.1e-10 41.6 5.1 0.62 10.5 0.1 8.9 8 2 2 10 10 10 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84635.1 - 1.2e-08 34.5 5.0 5.5 7.9 0.0 10.4 11 1 1 12 12 12 1 Ankyrin repeat SH3BGR PF04908.15 EFA84636.1 - 1.1e-15 57.6 0.8 1.6e-15 57.1 0.8 1.3 1 1 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EFA84636.1 - 2.3e-11 43.7 0.1 3.7e-11 43.1 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 EFA84636.1 - 0.085 13.3 0.0 0.1 13.0 0.0 1.1 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA84636.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain RhoGAP PF00620.27 EFA84637.1 - 2.1e-35 121.8 0.1 8.1e-35 119.9 0.1 2.0 1 0 0 1 1 1 1 RhoGAP domain BAR_3 PF16746.5 EFA84637.1 - 5e-17 62.4 8.1 5e-17 62.4 8.1 2.2 1 1 1 2 2 2 1 BAR domain of APPL family BAR PF03114.18 EFA84637.1 - 6.2e-08 32.6 11.3 1.1e-07 31.8 11.3 1.3 1 0 0 1 1 1 1 BAR domain P_C PF06640.11 EFA84637.1 - 0.89 9.7 3.0 1.6 8.8 3.0 1.3 1 0 0 1 1 1 0 P protein C-terminus zf-met PF12874.7 EFA84638.1 - 0.0048 17.2 0.3 0.015 15.7 0.3 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFA84638.1 - 0.0093 16.2 0.1 0.0093 16.2 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFA84638.1 - 0.092 13.6 7.6 0.72 10.9 0.5 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFA84638.1 - 0.3 11.6 14.1 1.3 9.6 2.5 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type SRP-alpha_N PF04086.13 EFA84638.1 - 2.7 7.8 49.7 4.4 7.2 49.7 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal tRNA-synt_1 PF00133.22 EFA84639.1 - 1.7e-50 172.0 0.0 3.3e-33 114.8 0.0 2.8 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFA84639.1 - 1.6e-20 73.2 0.4 1.4e-08 33.9 0.0 3.3 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFA84639.1 - 6.2e-15 55.5 0.2 1.5e-14 54.3 0.2 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFA84639.1 - 6.8e-07 28.9 0.1 6.6e-06 25.7 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain TMEM135_C_rich PF15982.5 EFA84640.1 - 3.4e-22 79.5 1.6 5.5e-22 78.8 1.6 1.3 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 CD20 PF04103.15 EFA84640.1 - 0.041 14.0 1.5 0.075 13.1 0.5 1.8 1 1 1 2 2 2 0 CD20-like family HTH_3 PF01381.22 EFA84641.1 - 3.1e-14 52.8 0.1 6.1e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 EFA84641.1 - 0.00056 19.9 0.1 0.0012 18.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MBF1 PF08523.10 EFA84641.1 - 0.0018 18.7 0.2 0.0034 17.8 0.2 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 MqsA_antitoxin PF15731.5 EFA84641.1 - 0.0099 16.0 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_31 PF13560.6 EFA84641.1 - 0.01 16.1 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_37 PF13744.6 EFA84641.1 - 0.11 12.4 0.3 0.21 11.6 0.3 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Phage_holin_3_1 PF05106.12 EFA84641.1 - 9.3 6.8 8.8 0.89 10.0 1.1 2.8 2 2 1 3 3 3 0 Phage holin family (Lysis protein S) tRNA_int_endo PF01974.17 EFA84642.1 - 2e-12 47.0 0.0 4.4e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain 4HBT PF03061.22 EFA84643.1 - 0.0027 18.0 0.0 0.77 10.2 0.0 2.2 2 0 0 2 2 2 2 Thioesterase superfamily PBCV_basic_adap PF08789.10 EFA84643.1 - 0.51 10.5 2.2 24 5.1 0.1 2.3 2 0 0 2 2 2 0 PBCV-specific basic adaptor domain Presenilin PF01080.17 EFA84643.1 - 7.4 5.2 10.4 0.75 8.5 2.3 2.1 2 0 0 2 2 2 0 Presenilin NST1 PF13945.6 EFA84643.1 - 9.2 6.3 34.0 0.77 9.8 16.2 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator E2F_TDP PF02319.20 EFA84644.1 - 1.8e-29 101.6 0.5 2.2e-13 50.0 0.0 2.5 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EFA84644.1 - 0.045 13.6 0.0 0.24 11.3 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Apis_Csd PF11671.8 EFA84644.1 - 2.1 8.3 16.6 2.7 8.0 4.2 2.5 2 0 0 2 2 2 0 Complementary sex determiner protein EVI2A PF05399.11 EFA84644.1 - 9.3 5.8 13.0 2.4 7.7 9.7 1.7 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Lyase_1 PF00206.20 EFA84646.1 - 3.9e-18 65.9 0.0 4.5e-18 65.7 0.0 1.0 1 0 0 1 1 1 1 Lyase Ribosomal_L15e PF00827.17 EFA84647.1 - 1.3e-86 289.3 4.7 2.7e-86 288.2 4.7 1.5 1 0 0 1 1 1 1 Ribosomal L15 Resolvase PF00239.21 EFA84647.1 - 0.0074 16.4 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 Resolvase, N terminal domain DPM2 PF07297.12 EFA84648.1 - 5.1e-35 119.6 3.8 5.6e-35 119.5 3.8 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EFA84648.1 - 5.4e-05 23.1 2.5 5.9e-05 23.0 2.5 1.0 1 0 0 1 1 1 1 PIG-P O-ag_pol_Wzy PF14296.6 EFA84648.1 - 0.0042 15.8 1.2 0.0042 15.8 1.2 1.0 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy PsbN PF02468.15 EFA84648.1 - 6 6.8 6.6 4.3 7.3 0.4 2.1 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) HMA PF00403.26 EFA84649.1 - 1.6e-06 28.5 0.1 2.6e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain PAP1 PF08601.10 EFA84649.1 - 0.00077 19.3 13.6 0.00087 19.1 13.6 1.0 1 0 0 1 1 1 1 Transcription factor PAP1 ASD2 PF08687.11 EFA84649.1 - 0.017 14.7 9.3 0.02 14.4 9.3 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Macoilin PF09726.9 EFA84649.1 - 0.032 12.8 10.3 0.035 12.7 10.3 1.0 1 0 0 1 1 1 0 Macoilin family RAB3GAP2_N PF14655.6 EFA84649.1 - 0.037 13.3 8.7 0.046 13.0 8.7 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ndc1_Nup PF09531.10 EFA84649.1 - 0.067 11.9 9.4 0.071 11.8 9.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ANAPC_CDC26 PF10471.9 EFA84649.1 - 0.077 13.8 14.8 0.19 12.6 4.7 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 MAP65_ASE1 PF03999.12 EFA84649.1 - 0.081 11.6 12.1 0.092 11.4 12.1 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TFIIA PF03153.13 EFA84649.1 - 0.086 12.8 13.8 0.092 12.7 13.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MSP1_C PF07462.11 EFA84649.1 - 0.12 11.1 4.0 0.14 10.8 4.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF3684 PF12449.8 EFA84649.1 - 0.21 9.3 13.8 0.28 8.9 13.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) Utp14 PF04615.13 EFA84649.1 - 0.22 10.0 9.8 0.24 9.9 9.8 1.0 1 0 0 1 1 1 0 Utp14 protein SprA-related PF12118.8 EFA84649.1 - 0.36 9.9 18.1 0.45 9.6 18.1 1.1 1 0 0 1 1 1 0 SprA-related family SMYLE_N PF18615.1 EFA84649.1 - 0.75 9.3 14.2 0.95 9.0 14.2 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF4698 PF15769.5 EFA84649.1 - 0.77 8.7 13.2 0.98 8.4 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) FAM60A PF15396.6 EFA84649.1 - 0.78 9.7 7.4 1.1 9.2 7.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 EFA84649.1 - 1.1 7.9 11.9 1.3 7.7 11.9 1.1 1 0 0 1 1 1 0 Presenilin Hydin_ADK PF17213.3 EFA84649.1 - 1.2 9.4 12.0 1.5 9.1 12.0 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Suf PF05843.14 EFA84649.1 - 1.6 8.7 11.1 1.9 8.4 11.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FNIP PF05725.12 EFA84650.1 - 2.2e-13 50.1 20.1 5.9e-05 23.2 0.0 7.6 6 3 2 8 8 8 6 FNIP Repeat Cullin PF00888.22 EFA84651.1 - 5.1e-145 484.5 17.6 7.3e-145 484.0 17.6 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFA84651.1 - 1.1e-24 86.3 0.4 2.7e-24 85.0 0.4 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain Pterin_4a PF01329.19 EFA84652.1 - 3.3e-20 72.1 0.0 4.2e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Imm40 PF15569.6 EFA84652.1 - 0.069 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 40 Hydrolase_4 PF12146.8 EFA84653.1 - 2.2e-14 53.3 0.5 1.5e-12 47.3 0.5 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFA84653.1 - 4.3e-09 36.2 0.0 1.1e-07 31.6 0.0 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFA84653.1 - 6.1e-06 27.0 0.0 9.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EFA84653.1 - 1e-05 25.4 0.0 0.16 11.7 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EFA84653.1 - 2.5e-05 24.1 0.8 0.22 11.1 0.0 2.5 2 1 1 3 3 3 2 alpha/beta hydrolase fold DLH PF01738.18 EFA84653.1 - 0.00028 20.5 0.0 0.017 14.6 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family AXE1 PF05448.12 EFA84653.1 - 0.0059 15.3 0.4 0.34 9.5 0.4 2.2 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_4 PF08386.10 EFA84653.1 - 0.031 14.4 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein 3HBOH PF10605.9 EFA84653.1 - 0.032 12.5 0.0 2.4 6.3 0.0 2.0 2 0 0 2 2 2 0 3HB-oligomer hydrolase (3HBOH) RMMBL PF07521.12 EFA84653.1 - 0.035 14.1 0.1 11 6.0 0.1 2.4 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain Peptidase_S15 PF02129.18 EFA84653.1 - 0.039 13.5 0.0 3.9 7.0 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1749 PF08538.10 EFA84653.1 - 0.048 12.7 0.0 0.067 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Esterase PF00756.20 EFA84653.1 - 0.092 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative esterase LIP PF03583.14 EFA84653.1 - 0.12 11.7 0.1 8 5.7 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase T2SSM PF04612.12 EFA84654.1 - 0.014 15.4 0.4 0.019 15.0 0.4 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M SURF6 PF04935.12 EFA84655.1 - 1.2e-30 106.9 38.9 1.2e-30 106.9 38.9 2.9 2 1 1 3 3 3 1 Surfeit locus protein 6 DUF3439 PF11921.8 EFA84655.1 - 0.15 12.0 11.0 0.35 10.8 11.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EFA84655.1 - 0.16 11.9 20.6 0.32 11.0 20.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 EFA84655.1 - 4.1 5.4 19.2 7.9 4.5 19.2 1.5 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pkinase_Tyr PF07714.17 EFA84656.1 - 1.2e-56 191.9 0.1 2.2e-56 191.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA84656.1 - 3.7e-49 167.5 0.1 1.3e-48 165.6 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EFA84656.1 - 4.6e-06 25.7 1.2 7.8e-06 24.9 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Cbl_N2 PF02761.14 EFA84656.1 - 2.2e-05 25.1 0.0 0.00011 22.9 0.0 2.2 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain SH2 PF00017.24 EFA84656.1 - 0.00036 20.6 0.0 0.00087 19.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SPX PF03105.19 EFA84656.1 - 0.012 15.6 0.3 0.015 15.3 0.3 1.2 1 0 0 1 1 1 0 SPX domain DUF4175 PF13779.6 EFA84656.1 - 5.7 4.7 10.9 7.9 4.2 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ubiquitin PF00240.23 EFA84657.1 - 1.1e-06 28.3 0.1 5.5e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 EFA84657.1 - 0.029 14.8 0.5 1.4 9.4 0.0 2.7 2 1 0 2 2 2 0 Ubiquitin-like domain Ehrlichia_rpt PF09528.10 EFA84657.1 - 0.045 13.2 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Ehrlichia tandem repeat (Ehrlichia_rpt) DUF4819 PF16090.5 EFA84657.1 - 0.081 13.0 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4819) SLED PF12140.8 EFA84657.1 - 0.18 12.3 0.9 0.39 11.3 0.3 1.8 2 0 0 2 2 2 0 SLED domain NIF PF03031.18 EFA84658.1 - 8.5e-19 67.9 0.2 1.4e-18 67.2 0.2 1.3 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase PhyH PF05721.13 EFA84659.1 - 2.6e-08 34.4 0.0 2.3e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFA84659.1 - 0.00025 19.9 0.4 1.6 7.4 0.1 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EFA84659.1 - 0.017 15.6 0.0 0.034 14.5 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Ank_2 PF12796.7 EFA84661.1 - 5.4e-08 33.3 0.0 1.6e-06 28.6 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA84661.1 - 2.4e-06 27.7 0.0 2.8e-05 24.3 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84661.1 - 7e-05 22.9 0.0 0.0024 18.2 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFA84661.1 - 0.0001 22.6 0.0 0.0075 16.7 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFA84661.1 - 0.00071 20.1 0.0 0.0055 17.3 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) TetR_C_4 PF08359.11 EFA84662.1 - 0.039 14.1 2.1 0.18 12.0 0.1 2.9 3 0 0 3 3 3 0 YsiA-like protein, C-terminal region Nop14 PF04147.12 EFA84662.1 - 0.062 11.5 4.8 0.036 12.3 1.9 2.0 2 0 0 2 2 2 0 Nop14-like family YebO PF13974.6 EFA84662.1 - 0.25 11.5 1.6 2.1 8.5 0.8 2.9 2 1 0 2 2 2 0 YebO-like protein Endotoxin_N PF03945.14 EFA84663.1 - 0.0051 16.6 0.1 0.0087 15.8 0.1 1.4 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain DMPK_coil PF08826.10 EFA84663.1 - 0.16 12.1 0.8 0.38 10.9 0.8 1.6 1 0 0 1 1 1 0 DMPK coiled coil domain like Drf_FH3 PF06367.16 EFA84664.1 - 0.011 15.4 1.9 0.013 15.1 0.3 1.9 2 0 0 2 2 2 0 Diaphanous FH3 Domain Stealth_CR3 PF17102.5 EFA84666.1 - 5e-15 55.1 0.2 1.4e-14 53.7 0.0 1.8 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 EFA84666.1 - 6.8e-05 22.7 0.0 0.00016 21.4 0.0 1.7 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 PhetRS_B1 PF18262.1 EFA84666.1 - 0.024 14.8 0.6 0.061 13.5 0.6 1.7 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain 3H PF02829.14 EFA84666.1 - 0.061 13.6 0.2 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 3H domain Guanylate_cyc PF00211.20 EFA84667.1 - 1.1e-90 302.1 2.6 2e-47 161.2 0.6 2.5 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EFA84667.1 - 0.0012 18.3 4.0 0.16 11.4 0.3 2.8 3 0 0 3 3 3 2 Heme NO binding associated FA_desaturase PF00487.24 EFA84667.1 - 4.6 7.0 8.0 8.9 6.1 8.0 1.5 1 0 0 1 1 1 0 Fatty acid desaturase LSM PF01423.22 EFA84668.1 - 1.2e-15 56.9 0.3 1.6e-15 56.5 0.3 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA84668.1 - 0.00011 22.3 0.0 0.00015 21.9 0.0 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain LRR_9 PF14580.6 EFA84668.1 - 0.027 14.0 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 Leucine-rich repeat DEAD PF00270.29 EFA84669.1 - 4.2e-29 101.6 0.8 1e-28 100.3 0.2 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA84669.1 - 1.5e-22 80.0 0.1 5.6e-22 78.2 0.0 2.0 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA84669.1 - 0.0011 19.0 0.3 0.0029 17.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit LRR_8 PF13855.6 EFA84670.1 - 6.5e-21 73.9 38.7 1.4e-08 34.4 1.9 6.3 5 2 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFA84670.1 - 5.1e-14 52.2 43.0 0.0022 18.3 1.8 9.2 6 3 2 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA84670.1 - 4.7e-06 26.4 30.5 0.82 10.5 0.2 11.4 10 2 2 12 12 12 3 Leucine Rich Repeat LRRNT_2 PF08263.12 EFA84670.1 - 0.0038 17.5 1.6 0.0098 16.2 1.6 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain CBM_1 PF00734.18 EFA84670.1 - 0.19 11.7 1.2 0.61 10.1 1.2 2.0 1 0 0 1 1 1 0 Fungal cellulose binding domain MSC PF09402.10 EFA84670.1 - 0.28 10.6 2.5 0.33 10.3 1.0 1.9 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain TRP PF06011.12 EFA84670.1 - 6.9 5.3 27.8 57 2.3 27.8 2.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel TIG PF01833.24 EFA84671.1 - 0.00071 19.6 12.5 0.039 14.0 0.4 3.4 3 0 0 3 3 3 2 IPT/TIG domain DUF1350 PF07082.11 EFA84671.1 - 0.071 12.4 0.4 0.7 9.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1350) Ank_2 PF12796.7 EFA84673.1 - 9.7e-16 58.1 6.0 0.00021 21.8 0.7 6.0 4 1 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84673.1 - 3.7e-10 40.1 8.2 0.063 13.9 0.0 7.3 6 2 1 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84673.1 - 9.2e-07 29.0 3.0 3.5 8.0 0.0 6.6 3 2 3 7 7 7 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84673.1 - 3.7e-05 23.8 1.4 1.1e+02 3.9 0.0 8.3 9 0 0 9 9 9 0 Ankyrin repeat zf-C2H2_aberr PF17017.5 EFA84673.1 - 0.01 16.0 5.9 0.043 14.0 0.8 2.7 2 0 0 2 2 2 0 Aberrant zinc-finger Transglut_core PF01841.19 EFA84674.1 - 1.9e-11 44.4 0.0 3.5e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily ArgoMid PF16487.5 EFA84674.1 - 0.11 12.7 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 Mid domain of argonaute Corona_nucleoca PF00937.18 EFA84675.1 - 0.007 15.4 1.9 0.011 14.8 1.9 1.3 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein SR-25 PF10500.9 EFA84675.1 - 0.16 11.5 9.2 0.23 11.0 9.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SUZ PF12752.7 EFA84675.1 - 1.6 9.6 7.0 5.9 7.7 0.0 2.4 2 0 0 2 2 2 0 SUZ domain RRM_1 PF00076.22 EFA84676.1 - 3.9e-27 93.9 1.4 6.7e-16 57.9 0.1 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFA84676.1 - 0.00071 19.4 0.0 0.27 11.1 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif TPR_14 PF13428.6 EFA84676.1 - 0.01 16.6 0.1 4.2 8.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat PhetRS_B1 PF18262.1 EFA84676.1 - 0.045 14.0 0.1 8.4 6.7 0.0 3.0 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain ALMT PF11744.8 EFA84676.1 - 0.053 12.3 3.8 0.16 10.8 3.8 1.8 1 0 0 1 1 1 0 Aluminium activated malate transporter IF4E PF01652.18 EFA84677.1 - 4.5e-46 156.6 0.9 5.6e-46 156.2 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E FNIP PF05725.12 EFA84678.1 - 3.3e-31 107.2 22.6 5.1e-07 29.7 0.1 8.6 5 2 2 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA84678.1 - 0.0069 15.9 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 F-box DUF4363 PF14276.6 EFA84679.1 - 0.00046 20.3 1.2 0.0018 18.4 0.6 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4363) DUF3452 PF11934.8 EFA84679.1 - 0.0019 17.7 2.1 0.47 10.0 0.2 2.9 2 1 0 2 2 2 2 Domain of unknown function (DUF3452) DUF1978 PF09321.10 EFA84679.1 - 0.18 11.1 10.7 0.018 14.4 1.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) Rhodanese PF00581.20 EFA84680.1 - 1.6e-24 86.4 0.0 2.2e-11 44.2 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Mucin PF01456.17 EFA84681.1 - 1.4 8.9 11.2 2.9 7.9 11.2 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Stealth_CR4 PF17103.5 EFA84682.1 - 6.8e-22 77.1 0.7 3.3e-21 74.9 0.2 2.5 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 EFA84682.1 - 4e-18 65.0 3.4 8.6e-18 64.0 3.4 1.6 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Notch PF00066.17 EFA84682.1 - 6.5e-13 48.9 35.4 6.2e-07 29.8 14.7 2.4 2 0 0 2 2 2 2 LNR domain Stealth_CR2 PF11380.8 EFA84682.1 - 3.3e-06 27.2 0.0 2.5e-05 24.4 0.0 2.5 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 DUF812 PF05667.11 EFA84683.1 - 2.1e-183 611.4 23.9 2.1e-183 611.4 23.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF812) PAP2 PF01569.21 EFA84683.1 - 3.9e-20 72.0 1.8 7.1e-20 71.2 1.8 1.4 1 0 0 1 1 1 1 PAP2 superfamily Cytochrome_C7 PF14522.6 EFA84683.1 - 0.051 13.6 3.3 0.17 11.9 3.3 1.9 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c PSCyt3 PF07627.11 EFA84683.1 - 0.26 11.6 2.5 0.3 11.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) ANAPC4 PF12896.7 EFA84683.1 - 0.5 9.8 11.2 0.039 13.5 0.5 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 4 Cytochrom_NNT PF03264.14 EFA84683.1 - 2.1 8.0 7.8 0.41 10.3 1.4 2.8 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region TIG PF01833.24 EFA84684.1 - 1.6e-13 50.5 37.2 7.5e-09 35.6 2.3 6.6 7 0 0 7 7 7 4 IPT/TIG domain EGF_2 PF07974.13 EFA84684.1 - 0.00047 20.5 13.4 0.001 19.4 13.4 1.6 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 EFA84684.1 - 0.37 11.0 8.6 0.82 9.9 8.6 1.5 1 0 0 1 1 1 0 Laminin EGF domain ELFV_dehydrog_N PF02812.18 EFA84685.1 - 1.6e-55 186.5 0.0 2.8e-55 185.7 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 EFA84685.1 - 2e-54 184.9 0.1 3.9e-52 177.4 0.0 2.2 1 1 1 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AdoHcyase_NAD PF00670.21 EFA84685.1 - 0.0012 19.0 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFA84685.1 - 0.024 14.0 0.1 0.044 13.2 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Bac_GDH PF05088.12 EFA84685.1 - 0.027 12.0 0.0 0.87 7.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial NAD-glutamate dehydrogenase NAD_binding_7 PF13241.6 EFA84685.1 - 0.11 13.0 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding DnaJ PF00226.31 EFA84686.1 - 1e-24 86.4 0.8 2e-24 85.5 0.5 1.7 2 0 0 2 2 2 1 DnaJ domain SR-25 PF10500.9 EFA84686.1 - 0.00043 20.0 16.3 0.00043 20.0 16.3 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF1977 PF09320.11 EFA84686.1 - 0.0026 18.0 0.1 0.0065 16.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) TPR_2 PF07719.17 EFA84686.1 - 0.0078 16.3 0.0 0.43 10.8 0.0 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat Leu_zip PF15294.6 EFA84686.1 - 0.037 13.5 0.2 0.037 13.5 0.2 2.1 2 0 0 2 2 2 0 Leucine zipper Menin PF05053.13 EFA84686.1 - 0.36 9.1 5.2 0.47 8.8 5.2 1.1 1 0 0 1 1 1 0 Menin Apt1 PF10351.9 EFA84686.1 - 0.46 9.3 11.3 0.7 8.7 11.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain EBP50_C PF09007.11 EFA84686.1 - 2.1 9.3 11.7 1.4 10.0 9.3 1.9 2 0 0 2 2 2 0 EBP50, C-terminal Presenilin PF01080.17 EFA84686.1 - 6.1 5.5 7.0 9.3 4.9 7.0 1.2 1 0 0 1 1 1 0 Presenilin HAD_2 PF13419.6 EFA84687.1 - 1.1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFA84687.1 - 0.018 15.3 0.0 0.088 13.1 0.0 1.7 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Ank_2 PF12796.7 EFA84688.1 - 7.2e-27 93.8 2.1 8.7e-08 32.6 0.0 5.2 4 1 0 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA84688.1 - 2.8e-22 78.5 7.4 0.0032 17.8 0.0 9.6 7 3 3 10 10 10 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA84688.1 - 1.9e-20 72.9 7.1 0.00062 20.3 0.1 7.3 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84688.1 - 2.6e-16 58.1 5.1 0.43 11.3 0.0 9.4 11 0 0 11 11 11 5 Ankyrin repeat Ank PF00023.30 EFA84688.1 - 0.24 11.9 0.7 1.9e+02 2.8 0.1 5.0 4 2 0 4 4 4 0 Ankyrin repeat RSN1_7TM PF02714.15 EFA84689.1 - 0.038 13.3 0.6 0.066 12.5 0.1 1.7 1 1 1 2 2 2 0 Calcium-dependent channel, 7TM region, putative phosphate DUF3410 PF11890.8 EFA84689.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3410) Par3_HAL_N_term PF12053.8 EFA84690.1 - 0.26 11.5 1.2 0.31 11.3 0.3 1.6 2 1 0 2 2 2 0 N-terminal of Par3 and HAL proteins Ank_4 PF13637.6 EFA84694.1 - 6.9e-14 52.0 1.4 0.004 17.7 0.0 6.2 6 2 1 7 7 7 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84694.1 - 5.1e-09 36.6 0.2 0.49 11.0 0.0 5.2 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84694.1 - 3.5e-06 26.9 1.0 81 4.3 0.0 7.9 10 1 1 11 11 11 0 Ankyrin repeat DUF249 PF03158.13 EFA84694.1 - 0.0006 19.6 5.8 0.0016 18.2 1.3 3.1 2 2 0 3 3 3 1 Multigene family 530 protein HOIP-UBA PF16678.5 EFA84694.1 - 0.07 13.1 0.4 0.37 10.8 0.1 2.2 2 1 1 3 3 3 0 HOIP UBA domain pair GTP_EFTU PF00009.27 EFA84695.1 - 7.8e-55 185.4 0.0 2.6e-54 183.7 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFA84695.1 - 1.1e-36 125.5 0.0 3.2e-36 124.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Ank_2 PF12796.7 EFA84695.1 - 1.3e-17 64.1 8.1 1.2e-05 25.8 0.1 5.7 3 2 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84695.1 - 1.6e-14 54.0 6.3 3.6e-05 24.2 0.0 7.8 5 3 1 7 7 7 3 Ankyrin repeats (many copies) GTP_EFTU_D2 PF03144.25 EFA84695.1 - 6.2e-14 52.1 0.2 1.4e-13 51.0 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ank_3 PF13606.6 EFA84695.1 - 9e-10 38.0 2.2 17 6.4 0.0 8.7 9 1 1 10 10 10 1 Ankyrin repeat Ank_5 PF13857.6 EFA84695.1 - 1.9e-09 37.6 1.4 5.7 7.4 0.0 7.9 4 1 5 9 9 9 2 Ankyrin repeats (many copies) MMR_HSR1 PF01926.23 EFA84695.1 - 4.2e-05 23.6 0.1 0.0021 18.1 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EFA84695.1 - 0.061 13.2 0.2 0.18 11.7 0.2 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 tRNA-synt_1b PF00579.25 EFA84696.1 - 2.4e-22 79.6 0.0 1.5e-21 77.0 0.0 2.2 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) TMEM52 PF14979.6 EFA84698.1 - 0.39 10.6 2.2 0.55 10.1 2.2 1.2 1 0 0 1 1 1 0 Transmembrane 52 Insulin_TMD PF17870.1 EFA84698.1 - 2.4 8.3 6.7 0.5 10.5 3.0 1.7 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Lyase_8 PF02278.18 EFA84699.1 - 1e-76 257.8 5.0 1e-76 257.8 5.0 1.9 2 1 0 2 2 2 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_C PF02884.17 EFA84699.1 - 1.1e-17 64.2 0.1 4.3e-17 62.3 0.1 2.1 2 0 0 2 2 2 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Lyase_8_N PF08124.11 EFA84699.1 - 4.7e-08 32.3 0.9 7.5e-08 31.6 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide lyase family 8, N terminal alpha-helical domain MSA-2c PF12238.8 EFA84699.1 - 0.41 10.6 3.7 8.5 6.3 0.0 2.7 2 0 0 2 2 2 0 Merozoite surface antigen 2c Fucose_iso_N2 PF07882.12 EFA84700.1 - 0.008 15.8 0.1 3.7 7.1 0.0 2.5 1 1 1 2 2 2 2 L-fucose isomerase, second N-terminal domain ORC6 PF05460.13 EFA84700.1 - 0.25 10.6 9.5 0.28 10.4 0.1 2.5 2 1 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Dicty_CAR PF05462.11 EFA84701.1 - 3.1e-178 591.4 23.4 3.6e-178 591.2 23.4 1.0 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EFA84701.1 - 2.9e-09 36.6 19.8 4.7e-09 35.9 19.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Methyltransf_2 PF00891.18 EFA84702.1 - 1.6e-21 76.6 0.0 2e-19 69.7 0.0 2.2 1 1 1 2 2 2 2 O-methyltransferase domain Dimerisation2 PF16864.5 EFA84702.1 - 0.036 14.0 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain Med7 PF05983.11 EFA84704.1 - 8.7e-59 198.8 12.6 8.7e-59 198.8 12.6 2.1 2 1 0 2 2 2 1 MED7 protein DUF4481 PF14800.6 EFA84704.1 - 0.021 14.3 1.8 0.033 13.7 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) DnaG_DnaB_bind PF08278.11 EFA84704.1 - 0.1 13.2 0.3 0.2 12.2 0.3 1.5 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding FSA_C PF10479.9 EFA84704.1 - 0.14 10.2 23.1 0.012 13.8 12.1 2.0 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus HHH_5 PF14520.6 EFA84704.1 - 0.15 12.7 0.1 0.3 11.7 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain Ecl1 PF12855.7 EFA84704.1 - 3.5 8.8 33.5 3.4 8.8 8.3 2.2 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins Med4 PF10018.9 EFA84704.1 - 4.1 7.0 14.6 13 5.4 14.6 1.9 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Mucin PF01456.17 EFA84704.1 - 7.3 6.6 52.3 0.045 13.8 24.0 2.6 2 1 0 2 2 2 0 Mucin-like glycoprotein PPTA PF01239.22 EFA84705.1 - 6.9e-32 108.2 24.6 4.3e-08 32.6 0.1 6.5 6 0 0 6 6 6 6 Protein prenyltransferase alpha subunit repeat Methyltransf_2 PF00891.18 EFA84706.1 - 1e-28 100.1 0.0 2.1e-28 99.1 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 EFA84706.1 - 8.4e-05 23.2 0.0 0.0003 21.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA84706.1 - 0.00022 21.1 0.0 0.017 15.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Dimerisation2 PF16864.5 EFA84706.1 - 0.015 15.3 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain Methyltransf_25 PF13649.6 EFA84706.1 - 0.027 15.2 0.0 0.059 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain VIT PF08487.10 EFA84707.1 - 8.7e-33 112.9 1.3 2.5e-32 111.4 1.3 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EFA84707.1 - 2.7e-29 102.1 0.0 1.3e-28 99.9 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFA84707.1 - 2.2e-12 47.6 0.0 5.6e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA84707.1 - 1.5e-07 32.0 0.0 6.6e-07 30.0 0.0 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EFA84707.1 - 0.00013 21.8 0.1 0.00034 20.5 0.1 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain vWA-TerF-like PF10138.9 EFA84707.1 - 0.0015 18.7 0.0 0.0037 17.4 0.0 1.6 1 0 0 1 1 1 1 vWA found in TerF C terminus KTI12 PF08433.10 EFA84707.1 - 0.013 14.9 0.1 0.029 13.8 0.1 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Phage_TAC_13 PF16459.5 EFA84707.1 - 0.059 13.8 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone, TAC DUF3430 PF11912.8 EFA84708.1 - 2.3e-27 96.5 25.1 2.9e-27 96.1 25.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) Ank_2 PF12796.7 EFA84709.1 - 3.3e-26 91.7 2.8 2.8e-08 34.2 0.0 5.5 4 1 0 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84709.1 - 1.8e-22 79.4 10.3 1.6e-07 31.8 0.1 8.4 6 4 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84709.1 - 8.8e-19 67.3 12.6 0.0043 17.3 0.3 9.6 6 3 5 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84709.1 - 1.1e-12 46.9 10.3 0.053 14.1 0.0 10.3 11 1 1 12 12 12 3 Ankyrin repeat Ank PF00023.30 EFA84709.1 - 0.0013 19.1 1.3 35 5.1 0.0 5.8 6 0 0 6 6 6 1 Ankyrin repeat Ank_2 PF12796.7 EFA84710.1 - 1.3e-23 83.4 3.9 0.00036 21.1 0.0 6.6 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84710.1 - 1.1e-22 80.1 1.6 8.6e-05 23.0 0.0 8.2 6 3 1 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84710.1 - 4.5e-19 68.3 2.8 0.006 16.9 0.1 9.1 5 2 4 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84710.1 - 1.8e-16 58.5 0.4 2.9 8.8 0.0 10.4 8 2 2 10 10 10 3 Ankyrin repeat Ank PF00023.30 EFA84710.1 - 0.00093 19.5 0.1 41 4.9 0.0 5.1 4 1 0 4 4 4 0 Ankyrin repeat Ank_4 PF13637.6 EFA84711.1 - 0.09 13.4 0.0 2.8 8.6 0.0 3.1 2 1 0 2 2 2 0 Ankyrin repeats (many copies) Rit1_C PF17184.4 EFA84712.1 - 2.7e-87 292.7 3.2 6.5e-87 291.4 3.2 1.6 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EFA84712.1 - 1.2e-13 51.3 0.8 3.5e-13 49.8 0.8 1.8 1 0 0 1 1 1 1 Rit1 DUSP-like domain Methyltransf_12 PF08242.12 EFA84712.1 - 0.33 11.7 3.8 13 6.6 0.2 2.7 2 0 0 2 2 2 0 Methyltransferase domain ETRAMP PF09716.10 EFA84712.1 - 1.2 9.2 0.0 1.2 9.2 0.0 2.8 2 1 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Ank_2 PF12796.7 EFA84713.1 - 2.4e-36 124.2 25.3 2.3e-12 47.3 0.4 6.4 3 1 6 9 9 9 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84713.1 - 1.9e-27 95.2 17.4 9.4e-08 32.5 0.1 7.4 6 2 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84713.1 - 4e-25 87.6 14.9 0.00011 22.4 0.1 10.4 2 2 8 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84713.1 - 7.5e-19 65.9 17.1 0.42 11.3 0.0 11.7 12 1 1 13 13 13 6 Ankyrin repeat Ank PF00023.30 EFA84713.1 - 9e-07 29.1 10.0 0.94 10.0 0.0 7.2 4 1 3 7 7 7 2 Ankyrin repeat LURAP PF14854.6 EFA84713.1 - 0.018 15.0 0.0 8.5 6.4 0.0 3.1 3 0 0 3 3 3 0 Leucine rich adaptor protein zf-RRPl_C4 PF17026.5 EFA84714.1 - 0.13 12.4 1.3 0.23 11.6 1.3 1.4 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Ank_2 PF12796.7 EFA84716.1 - 4.4e-05 24.0 0.0 5.4e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA84716.1 - 8.8e-05 22.7 0.0 0.00044 20.5 0.0 1.9 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84716.1 - 0.0003 21.0 0.0 0.017 15.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EFA84716.1 - 0.0081 16.7 0.0 0.016 15.8 0.0 1.5 1 1 0 1 1 1 1 Ankyrin repeats (many copies) GST_N_3 PF13417.6 EFA84716.1 - 0.078 13.4 0.0 14 6.2 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain RPA_interact_N PF14766.6 EFA84718.1 - 0.00015 21.3 0.4 0.00038 20.0 0.4 1.6 1 0 0 1 1 1 1 Replication protein A interacting N-terminal DUF5349 PF17298.2 EFA84718.1 - 0.0095 15.7 14.5 0.011 15.5 14.5 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5349) MAP70 PF07058.11 EFA84718.1 - 0.44 9.2 7.9 0.66 8.6 7.9 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 Sdh5 PF03937.16 EFA84718.1 - 1.6 8.8 5.8 3.2 7.8 5.8 1.4 1 0 0 1 1 1 0 Flavinator of succinate dehydrogenase Asp4 PF16996.5 EFA84718.1 - 5.7 6.8 6.6 11 5.9 0.9 2.3 2 0 0 2 2 2 0 Accessory secretory protein Sec Asp4 DUF3439 PF11921.8 EFA84718.1 - 9.9 6.2 18.3 1.4 8.9 13.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) MOSC_N PF03476.16 EFA84720.1 - 1.8e-23 82.7 0.0 3.6e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 EFA84720.1 - 1.7e-22 79.9 0.0 3.5e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 MOSC domain DUF810 PF05664.11 EFA84720.1 - 4.7e-15 55.2 0.5 4.7e-15 55.2 0.5 1.8 2 1 0 2 2 2 1 Plant family of unknown function (DUF810) Sec6 PF06046.13 EFA84720.1 - 0.012 14.0 0.1 0.026 12.9 0.1 1.5 1 0 0 1 1 1 0 Exocyst complex component Sec6 TFIIA PF03153.13 EFA84720.1 - 0.75 9.7 32.4 1.7 8.5 32.4 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM70 PF14967.6 EFA84720.1 - 3.2 7.1 7.9 6.7 6.1 7.9 1.6 1 0 0 1 1 1 0 FAM70 protein Filamin PF00630.19 EFA84721.1 - 5.3e-126 412.6 13.8 7.7e-24 84.5 0.2 6.1 6 0 0 6 6 6 6 Filamin/ABP280 repeat CH PF00307.31 EFA84721.1 - 5.7e-43 145.5 0.0 5.9e-23 81.1 0.4 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 EFA84721.1 - 1.9e-25 89.0 8.4 0.005 17.1 0.0 6.3 6 0 0 6 6 6 6 Invasin, domain 3 YtkA PF13115.6 EFA84721.1 - 5e-09 36.7 12.8 0.17 12.5 0.0 6.5 5 1 2 7 7 7 3 YtkA-like Y_Y_Y PF07495.13 EFA84721.1 - 5.7e-09 35.8 7.3 1 9.4 0.0 6.4 6 0 0 6 6 6 4 Y_Y_Y domain CAMSAP_CH PF11971.8 EFA84721.1 - 2.4e-07 30.5 0.0 0.011 15.6 0.0 2.4 2 0 0 2 2 2 2 CAMSAP CH domain DUF5060 PF16586.5 EFA84721.1 - 2.6e-05 24.5 1.0 1.7 9.1 0.0 5.9 6 0 0 6 6 6 1 Domain of unknown function (DUF5060) Big_6 PF17936.1 EFA84721.1 - 0.004 17.4 16.0 11 6.3 0.1 7.3 7 1 1 8 8 8 1 Bacterial Ig domain Big_1 PF02369.16 EFA84721.1 - 0.021 14.8 7.4 3.5 7.7 0.1 5.5 5 1 2 7 7 7 0 Bacterial Ig-like domain (group 1) Wzt_C PF14524.6 EFA84721.1 - 0.024 14.7 0.0 3.9 7.5 0.0 3.1 3 0 0 3 3 3 0 Wzt C-terminal domain PKD PF00801.20 EFA84721.1 - 0.043 13.6 1.1 7.8 6.4 0.0 4.6 5 0 0 5 5 5 0 PKD domain Neurexophilin PF06312.12 EFA84721.1 - 0.056 12.9 1.3 20 4.5 0.0 4.2 5 0 0 5 5 5 0 Neurexophilin Big_3 PF07523.12 EFA84721.1 - 0.081 13.2 7.2 12 6.3 0.6 4.4 3 1 0 3 3 3 0 Bacterial Ig-like domain (group 3) Ank_2 PF12796.7 EFA84722.1 - 2e-34 118.0 11.4 0.002 18.7 0.0 10.9 7 3 2 11 11 11 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84722.1 - 1.6e-29 101.9 12.3 0.00011 22.7 0.0 13.2 11 5 2 13 13 13 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84722.1 - 1.6e-18 64.9 8.8 0.34 11.6 0.0 14.2 15 1 1 16 16 16 3 Ankyrin repeat Ank_5 PF13857.6 EFA84722.1 - 8.7e-15 54.6 1.2 0.13 12.6 0.0 11.2 9 3 4 13 13 13 2 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA84722.1 - 1.5e-05 24.8 20.2 0.00061 19.5 0.3 6.7 7 1 1 8 8 8 2 Multigene family 530 protein Ank PF00023.30 EFA84722.1 - 0.0014 19.0 0.2 57 4.4 0.0 6.3 8 0 0 8 8 8 0 Ankyrin repeat Helicase_PWI PF18149.1 EFA84722.1 - 0.018 15.2 6.1 12 6.1 0.1 5.6 4 2 1 5 5 5 0 N-terminal helicase PWI domain DUF4116 PF13475.6 EFA84722.1 - 0.062 13.0 6.0 0.28 10.9 0.2 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4116) Mo-nitro_C PF06967.11 EFA84722.1 - 0.12 12.3 0.0 28 4.8 0.0 2.8 2 0 0 2 2 2 0 Mo-dependent nitrogenase C-terminus Ank_4 PF13637.6 EFA84723.1 - 6e-18 65.0 2.7 0.00079 19.9 0.0 7.4 6 2 2 8 8 8 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84723.1 - 3.4e-17 62.8 2.0 0.0018 18.8 0.0 6.4 2 2 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84723.1 - 1.4e-09 37.4 0.8 44 5.1 0.0 9.6 10 0 0 10 10 10 0 Ankyrin repeat Ank_5 PF13857.6 EFA84723.1 - 2e-05 24.7 0.7 37 4.8 0.0 7.2 6 2 3 9 9 9 0 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA84723.1 - 0.00041 20.1 10.5 0.00069 19.4 0.8 3.7 3 1 1 4 4 4 1 Multigene family 530 protein DUF3119 PF11317.8 EFA84723.1 - 0.017 15.4 0.1 0.046 14.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) DUF4116 PF13475.6 EFA84723.1 - 0.034 13.9 0.3 0.22 11.3 0.3 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) DUF3447 PF11929.8 EFA84723.1 - 0.17 11.8 21.9 2 8.4 3.5 6.8 4 2 2 6 6 6 0 Domain of unknown function (DUF3447) TIG PF01833.24 EFA84724.1 - 1.7e-65 217.1 104.5 7.3e-12 45.2 1.7 13.3 13 0 0 13 13 13 12 IPT/TIG domain DNase_II PF03265.15 EFA84724.1 - 2.2e-32 112.6 1.3 1.6e-20 73.7 1.7 2.4 2 0 0 2 2 2 2 Deoxyribonuclease II DASH_Duo1 PF08651.10 EFA84724.1 - 0.12 12.1 0.3 0.48 10.2 0.3 2.0 1 0 0 1 1 1 0 DASH complex subunit Duo1 Ank_4 PF13637.6 EFA84725.1 - 0.0007 20.1 0.6 0.036 14.7 0.0 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84725.1 - 0.0014 18.9 0.0 0.071 13.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84725.1 - 0.045 14.4 0.0 3.1 8.5 0.0 2.4 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84725.1 - 0.052 14.1 0.1 54 4.8 0.0 3.9 3 1 1 4 4 4 0 Ankyrin repeat DAP_epimerase PF01678.19 EFA84726.1 - 2.5e-48 163.2 0.4 1.7e-27 96.0 0.0 3.6 3 1 0 3 3 3 3 Diaminopimelate epimerase Peroxin-13_N PF04088.13 EFA84726.1 - 0.051 13.8 0.2 0.099 12.9 0.2 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DHODB_Fe-S_bind PF10418.9 EFA84726.1 - 7.5 6.5 6.1 1.8 8.4 0.5 2.4 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Vps54_N PF10475.9 EFA84727.1 - 1.8e-78 263.8 9.2 1.8e-78 263.8 9.2 1.6 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EFA84727.1 - 2.2e-22 80.0 3.1 4e-22 79.1 0.0 2.8 3 1 0 3 3 3 1 Protein of unknown function C-terminus (DUF2451) MEA1 PF06910.11 EFA84727.1 - 0.0087 16.7 0.5 0.0087 16.7 0.5 2.8 2 0 0 2 2 2 1 Male enhanced antigen 1 (MEA1) UCH_N PF16674.5 EFA84727.1 - 0.063 13.2 4.5 1 9.4 0.0 3.2 3 1 0 3 3 3 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 Sec8_exocyst PF04048.14 EFA84727.1 - 0.11 12.4 2.8 0.11 12.4 0.2 2.5 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain IBN_N PF03810.19 EFA84728.1 - 0.051 13.5 1.2 30 4.6 0.0 3.7 4 0 0 4 4 4 0 Importin-beta N-terminal domain NTF2 PF02136.20 EFA84729.1 - 7.8e-21 74.9 0.1 9.9e-21 74.5 0.1 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain MINDY_DUB PF04424.13 EFA84730.1 - 1.8e-25 89.2 0.0 3.6e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase DUF3439 PF11921.8 EFA84730.1 - 9.7 6.2 28.3 0.17 11.9 11.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Ank_4 PF13637.6 EFA84731.1 - 1e-30 105.7 13.6 0.00021 21.8 0.1 11.0 6 3 7 13 13 13 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84731.1 - 5e-28 97.5 3.8 2.8e-05 24.6 0.0 7.2 1 1 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84731.1 - 2e-18 64.5 0.3 3.2 8.6 0.0 13.1 13 2 2 15 15 14 1 Ankyrin repeat Ank_5 PF13857.6 EFA84731.1 - 1.2e-16 60.6 2.8 0.00032 20.9 0.1 9.4 7 4 6 13 13 13 3 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA84731.1 - 0.00014 21.8 10.3 0.0093 15.9 0.2 5.9 3 3 2 5 5 5 1 Domain of unknown function (DUF3447) DUF5049 PF16468.5 EFA84731.1 - 0.0016 18.3 0.0 5.2 7.1 0.0 5.4 5 0 0 5 5 5 1 Domain of unknown function (DUF5049) DUF4411 PF14367.6 EFA84731.1 - 0.0089 15.9 1.1 6.6 6.6 0.1 4.2 1 1 3 4 4 4 1 Domain of unknown function (DUF4411) FBD PF08387.10 EFA84731.1 - 0.036 14.0 4.3 1.8 8.5 0.1 5.1 6 1 0 6 6 6 0 FBD Ank PF00023.30 EFA84731.1 - 0.055 13.9 0.0 5.3e+02 1.3 0.0 5.9 7 2 0 7 7 5 0 Ankyrin repeat HOIP-UBA PF16678.5 EFA84731.1 - 0.065 13.2 0.2 3 7.8 0.0 3.1 3 1 0 3 3 3 0 HOIP UBA domain pair HSR PF03172.13 EFA84731.1 - 0.074 13.2 0.1 0.27 11.4 0.1 2.0 1 0 0 1 1 1 0 HSR domain Xin PF08043.12 EFA84731.1 - 0.35 10.5 1.1 3.5 7.4 0.0 3.2 2 0 0 2 2 2 0 Xin repeat Laminin_EGF PF00053.24 EFA84732.1 - 0.027 14.6 12.8 0.032 14.4 4.6 3.0 2 0 0 2 2 2 0 Laminin EGF domain Nodulin_late PF07127.11 EFA84732.1 - 7.7 6.9 9.7 0.17 12.3 0.9 2.5 2 0 0 2 2 2 0 Late nodulin protein TIG PF01833.24 EFA84733.1 - 8.2e-09 35.4 9.4 9e-06 25.7 0.7 2.8 2 1 0 2 2 2 2 IPT/TIG domain DUF3535 PF12054.8 EFA84733.1 - 0.032 13.5 3.2 0.044 13.0 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) Zip PF02535.22 EFA84733.1 - 1.5 7.9 10.3 2 7.6 10.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NST1 PF13945.6 EFA84733.1 - 4 7.5 24.4 6.8 6.8 24.4 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator FAM60A PF15396.6 EFA84733.1 - 5 7.1 11.1 7.5 6.5 11.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 EFA84733.1 - 9.4 4.9 11.4 13 4.4 11.4 1.2 1 0 0 1 1 1 0 Presenilin CK2S PF15011.6 EFA84734.1 - 8.7e-05 22.5 9.7 0.056 13.3 5.5 2.7 1 1 1 2 2 2 2 Casein Kinase 2 substrate CPP1-like PF11833.8 EFA84735.1 - 3.9 7.1 5.6 4.1 7.0 5.6 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Ammonium_transp PF00909.21 EFA84736.1 - 8.5e-16 57.6 1.0 1.2e-15 57.1 1.0 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family IF4E PF01652.18 EFA84737.1 - 3e-39 134.3 0.8 8.8e-39 132.8 0.8 1.8 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E S-AdoMet_synt_M PF02772.16 EFA84737.1 - 6.6 7.0 8.6 34 4.7 8.5 2.3 1 1 0 1 1 1 0 S-adenosylmethionine synthetase, central domain ThiF PF00899.21 EFA84738.1 - 8e-17 61.4 0.0 1.3e-16 60.7 0.0 1.3 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EFA84738.1 - 3.4e-05 23.9 0.1 0.036 14.3 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin-activating enzyme E1 four-helix bundle CNOT1_TTP_bind PF16417.5 EFA84738.1 - 0.11 11.7 0.0 24 4.0 0.0 3.0 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 1 TTP binding domain Glyco_transf_22 PF03901.17 EFA84739.1 - 5.2e-52 177.5 32.5 5.2e-52 177.5 32.5 2.9 2 1 0 2 2 2 1 Alg9-like mannosyltransferase family GpcrRhopsn4 PF10192.9 EFA84739.1 - 7.2e-51 173.1 33.3 7.2e-51 173.1 33.3 2.9 4 0 0 4 4 4 1 Rhodopsin-like GPCR transmembrane domain TPR_19 PF14559.6 EFA84740.1 - 0.047 14.2 0.0 0.32 11.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat LtrA PF06772.11 EFA84740.1 - 0.048 12.9 0.1 0.068 12.4 0.1 1.1 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) PI3K_1B_p101 PF10486.9 EFA84740.1 - 0.35 8.6 12.6 0.41 8.4 12.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Glyco_hydro_15 PF00723.21 EFA84741.1 - 1.3e-54 185.7 0.0 2.5e-51 174.9 0.0 2.5 2 1 1 3 3 3 2 Glycosyl hydrolases family 15 RNA_pol_Rpc4 PF05132.14 EFA84742.1 - 0.054 13.9 0.3 0.098 13.1 0.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Mpp10 PF04006.12 EFA84742.1 - 1.3 7.3 29.1 2.2 6.6 29.1 1.3 1 0 0 1 1 1 0 Mpp10 protein DUF913 PF06025.12 EFA84742.1 - 2.4 7.0 11.6 7.6 5.4 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF2076 PF09849.9 EFA84742.1 - 6.8 6.7 16.9 10 6.1 16.9 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MFS_1 PF07690.16 EFA84745.1 - 5.1e-12 45.4 6.5 6.8e-12 45.0 6.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EFA84745.1 - 5.4e-10 38.4 5.4 7.8e-10 37.9 5.4 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein PUCC PF03209.15 EFA84745.1 - 2.8e-07 29.9 1.9 4.2e-07 29.3 1.9 1.1 1 0 0 1 1 1 1 PUCC protein zf-RVT PF13966.6 EFA84745.1 - 0.036 14.8 0.4 0.081 13.6 0.4 1.6 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase Nanovirus_coat PF04660.12 EFA84745.1 - 0.16 12.0 0.5 0.26 11.3 0.5 1.2 1 0 0 1 1 1 0 Nanovirus coat protein Patched PF02460.18 EFA84746.1 - 5.4e-100 335.7 15.0 4.9e-99 332.6 11.6 2.2 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 EFA84746.1 - 1.1e-51 174.7 27.2 1.8e-50 170.8 9.5 2.7 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation NPC1_N PF16414.5 EFA84746.1 - 8.7e-22 77.9 7.6 8.7e-22 77.9 7.6 1.8 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus ACR_tran PF00873.19 EFA84746.1 - 0.76 7.4 20.0 1.7 6.2 20.0 1.5 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Nop PF01798.18 EFA84747.1 - 4.3e-70 235.8 0.0 6.9e-70 235.1 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EFA84747.1 - 1.7e-31 109.6 3.9 1.7e-31 109.6 3.9 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain Peptidase_S66 PF02016.15 EFA84747.1 - 0.13 12.3 0.1 15 5.7 0.0 2.7 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain EnY2 PF10163.9 EFA84748.1 - 2.3e-26 92.0 0.4 2.3e-26 92.0 0.4 1.8 2 0 0 2 2 2 1 Transcription factor e(y)2 ABC_tran PF00005.27 EFA84749.1 - 4.9e-31 108.1 0.1 4.9e-31 108.1 0.1 2.3 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EFA84749.1 - 0.0062 16.4 1.3 0.011 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EFA84749.1 - 0.0072 16.5 0.1 0.2 11.9 0.1 2.8 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit MYO10_CC PF16735.5 EFA84749.1 - 0.01 15.9 0.2 0.068 13.3 0.1 2.2 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain RsgA_GTPase PF03193.16 EFA84749.1 - 0.031 14.2 0.4 0.078 12.9 0.1 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EFA84749.1 - 0.071 12.9 0.2 0.16 11.7 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EFA84749.1 - 0.97 9.9 3.1 17 5.9 3.1 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Myosin_head PF00063.21 EFA84750.1 - 7.7e-289 959.7 1.5 2.8e-288 957.8 1.5 2.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EFA84750.1 - 1e-72 245.5 342.8 3.4e-44 151.0 163.5 3.4 1 1 2 3 3 3 3 Myosin tail Filament PF00038.21 EFA84750.1 - 1e-09 38.4 297.6 0.00042 20.0 15.1 11.9 1 1 10 11 11 11 7 Intermediate filament protein Myosin_N PF02736.19 EFA84750.1 - 1.1e-09 38.0 0.5 3.3e-09 36.4 0.5 2.0 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Cortex-I_coil PF09304.10 EFA84750.1 - 0.0024 18.0 17.6 0.0024 18.0 17.6 16.4 3 2 12 16 16 10 2 Cortexillin I, coiled coil IQ PF00612.27 EFA84750.1 - 0.0032 17.1 3.0 0.0094 15.7 0.7 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif BRE1 PF08647.11 EFA84750.1 - 0.0037 17.3 19.9 0.0037 17.3 19.9 16.3 4 3 12 17 17 14 4 BRE1 E3 ubiquitin ligase TolA_bind_tri PF16331.5 EFA84750.1 - 0.023 14.7 0.2 0.023 14.7 0.2 17.2 9 6 11 21 21 20 0 TolA binding protein trimerisation AAA_22 PF13401.6 EFA84750.1 - 0.18 12.0 0.0 0.18 12.0 0.0 5.2 4 1 2 6 6 6 0 AAA domain AAA_16 PF13191.6 EFA84750.1 - 0.32 11.4 0.0 0.32 11.4 0.0 6.8 3 2 2 5 5 1 0 AAA ATPase domain HAS-barrel PF09378.10 EFA84750.1 - 3.9 7.7 7.8 30 4.8 0.4 4.9 2 1 1 3 3 3 0 HAS barrel domain Bact_lectin PF18483.1 EFA84751.1 - 1.9e-22 80.3 0.1 1.9e-22 80.3 0.1 2.6 2 1 1 3 3 3 1 Bacterial lectin Lectin_legB PF00139.19 EFA84751.1 - 2.7e-19 69.7 8.6 3.9e-18 65.9 0.0 2.3 2 0 0 2 2 2 2 Legume lectin domain Tam41_Mmp37 PF09139.11 EFA84752.1 - 7.5e-98 327.9 9.1 1.2e-97 327.3 9.1 1.2 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial SWIM PF04434.17 EFA84754.1 - 0.27 11.0 3.1 0.82 9.4 3.1 1.8 1 1 0 1 1 1 0 SWIM zinc finger Phage_gp53 PF11246.8 EFA84755.1 - 0.022 14.5 0.1 0.024 14.3 0.1 1.2 1 0 0 1 1 1 0 Base plate wedge protein 53 APH PF01636.23 EFA84755.1 - 0.19 11.6 0.0 0.25 11.2 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Soc PF16855.5 EFA84756.1 - 0.0057 17.1 0.1 0.21 12.1 0.0 2.9 3 0 0 3 3 3 1 Small outer capsid protein Mucin PF01456.17 EFA84757.1 - 3.9 7.5 23.9 3.7 7.5 8.7 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein MAS20 PF02064.15 EFA84758.1 - 0.004 17.3 6.3 0.012 15.8 0.3 2.3 2 0 0 2 2 2 1 MAS20 protein import receptor ARA70 PF12489.8 EFA84758.1 - 0.0049 17.0 4.8 0.0049 17.0 4.8 1.8 2 0 0 2 2 2 1 Nuclear coactivator TraG-D_C PF12696.7 EFA84758.1 - 3.9 7.5 13.8 0.047 13.7 2.6 2.8 2 1 1 3 3 3 0 TraM recognition site of TraD and TraG ANAPC_CDC26 PF10471.9 EFA84758.1 - 4.4 8.2 14.0 1.1 10.1 4.8 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Zw10 PF06248.13 EFA84759.1 - 8.8e-11 41.1 5.3 1.5e-09 37.0 4.8 2.4 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 Vps26 PF03643.15 EFA84760.1 - 3.8e-129 429.5 5.2 4.5e-129 429.3 5.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EFA84760.1 - 0.00031 20.8 1.5 0.26 11.3 0.1 3.2 2 1 1 4 4 4 2 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 EFA84760.1 - 0.0096 15.1 0.3 1.9 7.6 0.0 3.0 3 0 0 3 3 3 1 Rgp1 tRNA-synt_2 PF00152.20 EFA84761.1 - 6.1e-100 334.3 0.0 8.6e-100 333.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFA84761.1 - 2.6e-11 43.4 0.0 1.1e-10 41.4 0.0 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain GAD PF02938.14 EFA84761.1 - 1.1e-07 32.0 0.0 1.9e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 GAD domain tRNA-synt_2d PF01409.20 EFA84761.1 - 0.0016 17.9 0.0 0.15 11.5 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) DUF3931 PF13082.6 EFA84762.1 - 0.048 13.8 0.1 0.056 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3931) Glyco_hydro_25 PF01183.20 EFA84763.1 - 1.5e-13 51.3 0.0 1.8e-13 51.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 zf-CCCH PF00642.24 EFA84764.1 - 5.8e-18 64.3 41.5 3.2e-05 23.7 1.4 5.6 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA84764.1 - 4.5e-14 52.0 53.9 4e-06 26.7 5.2 6.3 6 1 0 6 6 6 4 Zinc finger domain Torus PF16131.5 EFA84764.1 - 2.5e-12 47.5 45.6 0.00016 22.4 0.3 6.5 2 1 4 6 6 6 5 Torus domain zf-CCCH_4 PF18044.1 EFA84764.1 - 1.3e-11 44.0 33.2 0.00015 21.4 0.2 4.7 4 0 0 4 4 4 4 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EFA84764.1 - 1.1e-08 35.2 11.2 1.1e-08 35.2 11.2 3.6 2 2 1 3 3 3 1 Zinc-finger containing family zf-CCHC PF00098.23 EFA84764.1 - 1.3e-07 31.4 17.9 0.00012 22.0 4.6 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_3 PF13917.6 EFA84764.1 - 1e-05 25.4 8.0 0.034 14.1 1.8 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EFA84764.1 - 0.078 12.7 8.9 1.2 8.9 1.8 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCCH_2 PF14608.6 EFA84764.1 - 1.1 9.8 48.2 1.1 9.8 6.3 6.5 6 0 0 6 6 6 0 RNA-binding, Nab2-type zinc finger SnoaL_2 PF12680.7 EFA84765.1 - 3.4e-05 24.4 0.0 3.6e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF3271 PF11675.8 EFA84765.1 - 0.0029 16.9 1.9 0.0031 16.8 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3271) SnoaL PF07366.12 EFA84765.1 - 0.004 17.0 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DUF4440 PF14534.6 EFA84765.1 - 0.12 12.8 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Alpha_kinase PF02816.18 EFA84766.1 - 4.6e-62 209.4 0.4 4.6e-62 209.4 0.4 4.5 5 1 0 5 5 5 1 Alpha-kinase family ArfGap PF01412.18 EFA84766.1 - 1.9e-11 44.0 0.1 1.9e-11 44.0 0.1 4.9 6 1 0 6 6 6 1 Putative GTPase activating protein for Arf SHOCT PF09851.9 EFA84766.1 - 0.0046 16.7 0.2 0.01 15.6 0.2 1.6 1 0 0 1 1 1 1 Short C-terminal domain DUF4135 PF13575.6 EFA84767.1 - 0.02 14.2 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF3825 PF12873.7 EFA84768.1 - 8.1e-52 176.1 1.7 1.2e-51 175.6 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3825) eIF3g PF12353.8 EFA84768.1 - 1.5 9.3 0.0 1.5 9.3 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G FHA PF00498.26 EFA84769.1 - 1.1e-16 60.9 1.9 1.2e-16 60.8 0.2 2.0 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EFA84769.1 - 4e-08 33.5 0.1 1.1e-07 32.0 0.0 1.8 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 EFA84769.1 - 0.083 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 FHA domain DUF3439 PF11921.8 EFA84769.1 - 0.66 9.9 11.3 8.2 6.4 6.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Cytochrom_C PF00034.21 EFA84770.1 - 9.2e-11 42.7 0.0 1.4e-10 42.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EFA84770.1 - 9.4e-08 32.3 1.4 2.8e-07 30.7 1.4 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EFA84770.1 - 3.6e-05 23.5 0.1 0.0017 18.1 0.1 2.1 2 0 0 2 2 2 1 Cytochrome c-550 domain DUF3365 PF11845.8 EFA84770.1 - 0.14 12.5 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Pkinase PF00069.25 EFA84771.1 - 1.2e-29 103.5 2.5 5.1e-29 101.5 2.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84771.1 - 9e-15 54.6 0.1 2.2e-10 40.3 0.1 2.1 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFA84771.1 - 0.0021 18.0 0.1 0.041 13.8 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFA84771.1 - 0.034 13.7 0.1 0.078 12.6 0.1 1.6 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EFA84771.1 - 0.038 13.3 0.0 0.084 12.2 0.0 1.5 1 0 0 1 1 1 0 Kinase-like DFF-C PF09033.10 EFA84771.1 - 0.075 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain EntA_Immun PF08951.10 EFA84771.1 - 9.9 6.6 9.9 0.83 10.1 1.0 3.5 4 1 0 4 4 4 0 Enterocin A Immunity MerR_2 PF13591.6 EFA84772.1 - 0.028 14.3 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 MerR HTH family regulatory protein SnoaL PF07366.12 EFA84772.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase Ribosomal_L1 PF00687.21 EFA84774.1 - 3.1e-30 105.4 5.7 3.1e-30 105.4 5.7 3.5 3 2 0 3 3 3 1 Ribosomal protein L1p/L10e family Beta-lactamase2 PF13354.6 EFA84775.1 - 3.5e-23 82.3 0.0 5e-22 78.5 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase enzyme family DPBB_1 PF03330.18 EFA84776.1 - 1.1e-10 41.6 3.1 1.9e-10 40.9 0.3 2.6 2 1 0 2 2 2 1 Lytic transglycolase EB PF01683.18 EFA84777.1 - 0.0075 16.5 4.5 0.014 15.6 4.5 1.4 1 0 0 1 1 1 1 EB module EGF_2 PF07974.13 EFA84777.1 - 0.069 13.5 15.1 0.19 12.2 15.1 1.7 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFA84777.1 - 0.3 11.2 6.5 0.82 9.8 6.5 1.7 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 EFA84777.1 - 3.9 7.9 14.6 0.48 10.8 9.9 2.0 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 EFA84777.1 - 5.7 7.7 10.3 1 10.1 5.1 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF His_Phos_1 PF00300.22 EFA84778.1 - 1.2e-26 93.7 0.0 1.4e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF3465 PF11948.8 EFA84778.1 - 0.028 14.3 0.0 0.21 11.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3465) Homeodomain PF00046.29 EFA84779.1 - 2e-11 43.5 0.5 3.8e-11 42.7 0.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EFA84779.1 - 9.7e-09 35.0 0.5 1.8e-08 34.1 0.5 1.4 1 0 0 1 1 1 1 Homeobox KN domain Bunya_RdRp PF04196.12 EFA84779.1 - 0.0052 15.2 1.4 0.0061 15.0 1.4 1.1 1 0 0 1 1 1 1 Bunyavirus RNA dependent RNA polymerase Proteasome PF00227.26 EFA84780.1 - 7.8e-36 123.3 0.1 9.2e-36 123.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Ank_2 PF12796.7 EFA84783.1 - 0.002 18.7 2.4 0.015 15.9 0.6 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84783.1 - 0.028 15.0 0.8 13 6.5 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeats (many copies) SAC3 PF12209.8 EFA84783.1 - 0.57 10.4 5.6 9.1 6.5 0.5 2.8 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain LRR_6 PF13516.6 EFA84784.1 - 0.00025 20.8 2.9 16 5.9 0.2 4.7 4 0 0 4 4 4 2 Leucine Rich repeat F-box_5 PF18511.1 EFA84784.1 - 0.007 15.9 2.4 0.007 15.9 2.4 2.4 3 1 0 3 3 3 1 F-box F-box-like PF12937.7 EFA84784.1 - 0.019 14.9 0.3 0.15 12.0 0.0 2.4 2 0 0 2 2 2 0 F-box-like LRR_8 PF13855.6 EFA84784.1 - 0.26 11.1 5.9 9.4 6.1 2.7 3.6 2 1 1 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 EFA84784.1 - 0.39 11.2 9.4 55 4.4 0.0 4.0 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Methyltransf_11 PF08241.12 EFA84785.1 - 2.3e-20 73.0 0.0 3.5e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84785.1 - 3.8e-19 69.2 0.0 7.2e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA84785.1 - 3.4e-16 59.4 0.0 5.1e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA84785.1 - 6e-15 55.5 0.0 7.3e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84785.1 - 2.3e-12 47.5 0.0 3.7e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA84785.1 - 4.3e-08 32.8 0.0 5.9e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFA84785.1 - 2.6e-06 27.1 0.0 4.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 EFA84785.1 - 1.3e-05 24.9 0.0 1.8e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_9 PF08003.11 EFA84785.1 - 1.4e-05 24.2 0.0 1.9e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 EFA84785.1 - 5.6e-05 22.6 0.0 9.2e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB CMAS PF02353.20 EFA84785.1 - 8.1e-05 22.0 0.0 9.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 EFA84785.1 - 8.3e-05 22.8 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.13 EFA84785.1 - 9.8e-05 21.9 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EFA84785.1 - 0.0014 18.6 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EFA84785.1 - 0.006 15.2 0.0 0.0088 14.6 0.0 1.3 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_18 PF12847.7 EFA84785.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EFA84785.1 - 0.067 13.0 0.0 0.13 12.1 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase zf-C3HC4_3 PF13920.6 EFA84787.1 - 6.6e-11 41.9 17.0 9.9e-11 41.3 17.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA84787.1 - 0.022 14.6 14.5 0.041 13.7 14.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CENP-F_leu_zip PF10473.9 EFA84787.1 - 2.9 7.9 41.2 3.2 7.8 13.8 3.2 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 EFA84787.1 - 4.3 6.1 37.0 4.2 6.2 28.9 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 EFA84787.1 - 8.6 6.5 34.5 3.8 7.7 12.8 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EFA84787.1 - 8.8 6.7 22.0 0.41 10.9 2.6 3.8 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Vps5 PF09325.10 EFA84788.1 - 1.4e-53 181.8 8.3 1.4e-53 181.8 8.3 1.7 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 EFA84788.1 - 8.2e-24 83.8 2.4 1.6e-23 82.8 0.3 2.4 2 0 0 2 2 2 1 PX domain BAR PF03114.18 EFA84788.1 - 0.0078 15.9 4.6 0.015 14.9 4.6 1.4 1 0 0 1 1 1 1 BAR domain ZnuA PF01297.17 EFA84788.1 - 0.025 14.0 0.9 0.12 11.7 0.6 2.1 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic RhoGAP PF00620.27 EFA84788.1 - 0.13 12.1 0.6 0.33 10.8 0.3 1.8 1 1 0 1 1 1 0 RhoGAP domain CPSase_L_D3 PF02787.19 EFA84788.1 - 0.16 12.3 1.0 0.6 10.5 0.0 2.2 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain zf-C3HC4_3 PF13920.6 EFA84789.1 - 3e-15 55.8 11.9 5.3e-15 55.0 11.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA84789.1 - 2.8e-05 23.9 12.3 5.6e-05 22.9 12.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFA84789.1 - 0.00015 22.0 13.6 0.00028 21.1 13.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-P11 PF03854.14 EFA84789.1 - 0.0049 16.5 9.4 0.0049 16.5 9.4 2.3 2 0 0 2 2 2 1 P-11 zinc finger zf-RING_5 PF14634.6 EFA84789.1 - 0.0052 16.7 11.6 0.01 15.8 11.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFA84789.1 - 0.11 12.4 13.5 0.22 11.4 13.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SSP160 PF06933.11 EFA84789.1 - 2.8 6.0 34.8 0.59 8.3 15.4 2.2 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Str_synth PF03088.16 EFA84790.1 - 2.7e-29 101.1 2.2 1.8e-13 50.4 0.0 5.2 6 2 0 6 6 6 2 Strictosidine synthase SGL PF08450.12 EFA84790.1 - 6.3e-23 81.6 0.1 2.8e-11 43.5 0.0 2.8 2 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EFA84790.1 - 2.5e-11 43.0 1.0 4.3 7.6 0.0 9.8 11 0 0 11 11 11 3 NHL repeat Arylesterase PF01731.20 EFA84790.1 - 7e-05 22.9 0.0 0.92 9.7 0.0 3.9 4 0 0 4 4 4 2 Arylesterase Lipin_N PF04571.14 EFA84790.1 - 0.06 13.3 0.0 12 6.0 0.0 2.9 2 0 0 2 2 2 0 lipin, N-terminal conserved region Str_synth PF03088.16 EFA84792.1 - 1.8e-16 60.0 0.4 6e-15 55.1 0.2 3.1 3 1 0 3 3 3 1 Strictosidine synthase SGL PF08450.12 EFA84792.1 - 5.9e-11 42.4 0.1 2.4e-10 40.4 0.1 1.8 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EFA84792.1 - 3.4e-06 26.8 4.0 3.4 7.9 0.0 5.7 6 0 0 6 6 6 3 NHL repeat Arylesterase PF01731.20 EFA84792.1 - 0.12 12.6 0.2 0.71 10.1 0.0 2.3 2 0 0 2 2 2 0 Arylesterase bMG10 PF17973.1 EFA84793.1 - 4.3e-24 85.2 0.0 1.2e-23 83.7 0.0 1.8 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain ubiquitin PF00240.23 EFA84793.1 - 1.8e-14 53.2 0.2 4.4e-07 29.6 0.1 3.8 3 0 0 3 3 3 2 Ubiquitin family A2M PF00207.22 EFA84793.1 - 1.5e-11 44.0 0.0 4.7e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFA84793.1 - 2e-06 28.1 0.0 3.4e-05 24.2 0.0 3.1 2 0 0 2 2 2 1 MG2 domain Rad60-SLD PF11976.8 EFA84793.1 - 0.00014 21.7 2.6 0.46 10.3 0.1 3.6 4 0 0 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like PKD PF00801.20 EFA84793.1 - 0.066 13.1 0.7 5.4 6.9 0.0 3.6 3 0 0 3 3 3 0 PKD domain CRIM PF16978.5 EFA84794.1 - 1.8e-05 24.9 0.0 0.0034 17.5 0.0 3.1 2 0 0 2 2 2 2 SAPK-interacting protein 1 (Sin1), middle CRIM domain RNA_pol PF00940.19 EFA84795.1 - 6.9e-166 552.2 0.0 2.1e-165 550.6 0.0 1.8 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EFA84795.1 - 4.4e-30 105.2 5.1 4.4e-30 105.2 5.1 2.8 2 1 0 2 2 2 1 DNA-directed RNA polymerase N-terminal PPI_Ypi1 PF07491.11 EFA84795.1 - 3.4e-08 33.2 6.3 1e-07 31.6 6.3 1.8 1 0 0 1 1 1 1 Protein phosphatase inhibitor Dpoe2NT PF12213.8 EFA84795.1 - 0.11 12.7 2.2 1 9.7 0.0 2.9 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal Glyco_hydro_79C PF16862.5 EFA84795.1 - 0.38 11.7 3.6 1 10.3 3.6 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 79 C-terminal beta domain Phospholip_B PF04916.13 EFA84796.1 - 6.7e-145 483.7 12.3 7.9e-145 483.4 12.3 1.0 1 0 0 1 1 1 1 Phospholipase B Ras PF00071.22 EFA84797.1 - 6.4e-60 201.4 0.7 8.4e-60 201.0 0.7 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA84797.1 - 5.5e-34 117.0 0.1 8e-34 116.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA84797.1 - 1.6e-13 50.4 0.3 1.9e-13 50.2 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA84797.1 - 2.6e-07 30.7 0.1 4.3e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA84797.1 - 3.3e-05 23.8 0.1 0.0097 15.8 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFA84797.1 - 0.00014 21.5 0.3 0.00056 19.5 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFA84797.1 - 0.00017 21.0 0.1 0.00022 20.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFA84797.1 - 0.00017 21.0 0.0 0.00035 20.0 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EFA84797.1 - 0.00032 21.1 0.0 0.00047 20.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFA84797.1 - 0.0017 18.6 0.1 0.016 15.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EFA84797.1 - 0.0019 18.0 0.0 0.0052 16.5 0.0 1.8 1 1 1 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFA84797.1 - 0.014 15.2 0.2 0.025 14.3 0.2 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA84797.1 - 0.038 14.5 0.2 0.062 13.8 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 EFA84797.1 - 0.045 13.3 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EFA84797.1 - 0.048 13.9 0.7 0.38 11.0 0.7 2.1 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFA84797.1 - 0.059 12.8 0.0 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein MCM PF00493.23 EFA84797.1 - 0.087 11.9 0.0 0.18 10.9 0.0 1.6 1 1 0 1 1 1 0 MCM P-loop domain FeoB_N PF02421.18 EFA84797.1 - 0.13 11.7 0.2 0.47 10.0 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_21 PF13304.6 EFA84797.1 - 0.2 11.4 1.4 0.34 10.7 0.5 1.7 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Cofilin_ADF PF00241.20 EFA84798.1 - 1.5e-12 47.3 0.0 1.8e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF1939 PF09154.10 EFA84799.1 - 0.013 15.6 0.0 0.018 15.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) Fer2_3 PF13085.6 EFA84800.1 - 1.2e-32 112.1 0.0 1.9e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EFA84800.1 - 3.3e-09 37.2 2.3 3.3e-09 37.2 2.3 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFA84800.1 - 5.9e-08 33.0 7.5 1.9e-06 28.2 7.5 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFA84800.1 - 5.9e-08 32.7 1.6 5.9e-08 32.7 1.6 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 EFA84800.1 - 0.016 15.4 0.6 0.87 9.8 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer2 PF00111.27 EFA84800.1 - 0.024 14.6 0.4 0.024 14.6 0.4 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_16 PF13484.6 EFA84800.1 - 0.13 13.2 7.3 5 8.1 0.0 2.9 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 EFA84800.1 - 2.9 8.1 15.5 13 6.0 5.1 3.1 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFA84800.1 - 5.1 7.8 18.0 0.66 10.6 9.5 3.0 2 2 1 3 3 3 0 4Fe-4S dicluster domain Fz PF01392.22 EFA84801.1 - 0.00077 20.1 1.2 0.00077 20.1 1.2 2.2 2 0 0 2 2 2 1 Fz domain DUF3438 PF11920.8 EFA84801.1 - 0.85 8.8 4.3 1.2 8.3 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) Sh_2 PF17512.2 EFA84801.1 - 2.1 8.1 9.5 0.26 11.0 4.7 1.9 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein Aldo_ket_red PF00248.21 EFA84802.1 - 8.2e-50 169.7 0.0 5.1e-48 163.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family LRR_4 PF12799.7 EFA84803.1 - 5.8e-18 64.7 33.9 0.0015 18.9 1.1 8.5 5 2 2 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA84803.1 - 1.4e-14 53.5 35.2 1.1e-07 31.5 2.5 6.9 5 2 3 8 8 8 6 Leucine rich repeat LRR_6 PF13516.6 EFA84803.1 - 3.1e-14 51.7 27.1 0.031 14.3 0.2 11.3 12 0 0 12 12 12 5 Leucine Rich repeat Peptidase_M1 PF01433.20 EFA84803.1 - 0.2 11.2 0.0 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 Peptidase family M1 domain DNA_pol_phi PF04931.13 EFA84803.1 - 3.5 5.6 14.6 6.3 4.8 14.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi FAM177 PF14774.6 EFA84804.1 - 4.2e-14 52.9 1.5 6.1e-14 52.4 1.5 1.2 1 0 0 1 1 1 1 FAM177 family zf-CHY PF05495.12 EFA84805.1 - 3.4e-14 53.1 15.7 5.1e-14 52.5 15.7 1.3 1 0 0 1 1 1 1 CHY zinc finger Zn-ribbon_8 PF09723.10 EFA84805.1 - 0.0014 18.7 1.7 0.0014 18.7 1.7 2.5 2 1 0 2 2 2 1 Zinc ribbon domain NOB1_Zn_bind PF08772.11 EFA84805.1 - 0.0029 17.7 0.4 0.0029 17.7 0.4 2.0 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like Protamine_like PF06382.11 EFA84805.1 - 0.0039 17.4 3.5 0.0046 17.1 3.5 1.2 1 0 0 1 1 1 1 Protamine and protamine like Zn_ribbon_SprT PF17283.2 EFA84805.1 - 0.0091 15.9 5.8 0.057 13.3 0.5 2.5 2 0 0 2 2 2 1 SprT-like zinc ribbon domain Cys_rich_KTR PF14205.6 EFA84805.1 - 0.011 15.5 6.4 0.48 10.3 2.5 2.4 1 1 1 2 2 2 0 Cysteine-rich KTR zinc_ribbon_9 PF14369.6 EFA84805.1 - 0.017 15.3 7.5 0.05 13.9 0.1 3.2 3 1 0 3 3 3 0 zinc-ribbon Zn_Tnp_IS1595 PF12760.7 EFA84805.1 - 0.019 15.0 10.3 0.95 9.5 7.2 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain HypA PF01155.19 EFA84805.1 - 0.038 14.0 2.3 0.038 14.0 2.3 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PhnA_Zn_Ribbon PF08274.12 EFA84805.1 - 0.064 13.2 4.6 4.7 7.3 2.3 3.1 2 1 0 2 2 2 0 PhnA Zinc-Ribbon Elf1 PF05129.13 EFA84805.1 - 0.071 13.2 10.1 0.46 10.6 8.9 2.1 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DUF3797 PF12677.7 EFA84805.1 - 0.079 12.9 0.1 0.079 12.9 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3797) zinc_ribbon_4 PF13717.6 EFA84805.1 - 0.21 11.6 12.7 1.3 9.0 0.2 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS91 PF14319.6 EFA84805.1 - 0.22 11.6 12.6 2.1 8.5 7.7 2.3 1 1 1 2 2 2 0 Transposase zinc-binding domain DpnI PF06044.12 EFA84805.1 - 0.86 9.2 5.8 0.31 10.7 2.9 1.6 1 1 1 2 2 2 0 Dam-replacing family zf-C2H2 PF00096.26 EFA84805.1 - 2 9.1 9.7 2.7 8.6 0.4 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zinc_ribbon_15 PF17032.5 EFA84805.1 - 2 9.2 11.7 17 6.2 11.6 2.4 1 1 0 1 1 1 0 zinc-ribbon family Beta_helix PF13229.6 EFA84806.1 - 6.2e-11 42.4 20.2 6.2e-11 42.4 20.2 3.2 2 1 1 3 3 3 2 Right handed beta helix region NosD PF05048.13 EFA84806.1 - 1.9e-10 40.4 12.2 9.9e-08 31.5 3.9 3.6 1 1 1 3 3 3 3 Periplasmic copper-binding protein (NosD) Lon_C PF05362.13 EFA84807.1 - 4.9e-71 238.5 0.0 7.7e-71 237.9 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EFA84807.1 - 1.8e-17 64.0 0.2 1.9e-16 60.7 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFA84807.1 - 4.1e-06 26.6 0.0 1.1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ChlI PF13541.6 EFA84807.1 - 6.5e-06 26.0 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EFA84807.1 - 0.0003 21.2 0.1 0.00072 20.0 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFA84807.1 - 0.00095 19.2 0.0 0.0023 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFA84807.1 - 0.0011 18.3 0.9 0.0022 17.3 0.3 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_PrkA PF08298.11 EFA84807.1 - 0.0024 16.9 0.0 0.0042 16.0 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain Mg_chelatase PF01078.21 EFA84807.1 - 0.014 14.8 0.1 0.066 12.6 0.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFA84807.1 - 0.034 14.7 0.1 0.034 14.7 0.1 2.2 2 0 0 2 2 1 0 AAA domain AAA_22 PF13401.6 EFA84807.1 - 0.041 14.2 0.2 0.11 12.8 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFA84807.1 - 0.042 13.6 0.3 0.098 12.4 0.3 1.6 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 EFA84807.1 - 0.063 13.4 0.8 0.21 11.7 0.1 2.4 3 0 0 3 3 3 0 Shikimate kinase AAA_6 PF12774.7 EFA84807.1 - 0.082 11.9 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 EFA84807.1 - 0.09 12.8 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EFA84807.1 - 0.34 11.1 0.1 0.34 11.1 0.1 1.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EFA84807.1 - 2.1 7.4 9.0 5.6 6.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) SnoaL_2 PF12680.7 EFA84808.1 - 0.0015 19.1 0.0 0.0018 18.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EFA84808.1 - 0.015 15.1 0.0 0.016 15.0 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase DUF4440 PF14534.6 EFA84808.1 - 0.18 12.2 0.0 0.19 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Ycf34 PF10718.9 EFA84809.1 - 0.32 11.7 0.1 0.32 11.7 0.1 2.6 2 0 0 2 2 2 0 Hypothetical chloroplast protein Ycf34 Pex14_N PF04695.13 EFA84809.1 - 0.71 10.5 9.7 0.18 12.4 3.1 2.7 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region KCNQ2_u3 PF16642.5 EFA84809.1 - 9.1 7.4 9.2 33 5.5 0.2 2.4 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Dickkopf_N PF04706.12 EFA84810.1 - 0.0038 17.7 3.1 0.0038 17.7 3.1 6.1 7 0 0 7 7 7 3 Dickkopf N-terminal cysteine-rich region U3_assoc_6 PF08640.11 EFA84811.1 - 3.9e-18 65.3 4.2 1.3e-17 63.6 2.9 2.7 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 DHOase PF12890.7 EFA84811.1 - 0.097 12.6 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 Dihydro-orotase-like KIX_2 PF16987.5 EFA84811.1 - 0.38 10.8 5.1 0.34 10.9 0.5 3.2 3 0 0 3 3 3 0 KIX domain WD40 PF00400.32 EFA84812.1 - 2.1e-05 25.2 4.1 0.28 12.1 0.1 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFA84813.1 - 0.0071 15.4 0.2 0.019 14.0 0.0 1.7 3 0 0 3 3 3 1 Coatomer WD associated region GCV_T PF01571.21 EFA84814.1 - 1.6e-88 296.4 0.0 2.1e-88 296.0 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EFA84814.1 - 1.3e-18 66.7 0.0 2.5e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 EFA84814.1 - 3.2e-08 33.8 0.6 4.8e-07 30.0 0.0 2.7 3 1 1 4 4 4 1 Sarcosine oxidase, gamma subunit family SprT-like PF10263.9 EFA84815.1 - 6e-09 35.8 0.0 6e-09 35.8 0.0 2.6 3 0 0 3 3 3 1 SprT-like family Complex1_LYR PF05347.15 EFA84815.1 - 6.3e-06 26.1 0.9 3.5e-05 23.7 0.9 2.3 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Dynamin_M PF01031.20 EFA84816.1 - 3.3e-91 305.4 0.3 7.7e-91 304.2 0.3 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EFA84816.1 - 2.4e-52 177.4 0.0 8.3e-52 175.6 0.0 2.0 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EFA84816.1 - 1.3e-20 73.4 5.0 6.4e-20 71.1 5.0 2.3 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFA84816.1 - 5.7e-05 23.2 0.1 0.0003 20.9 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFA84816.1 - 0.03 14.7 0.1 8.5 6.7 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFA84816.1 - 0.043 13.7 0.1 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 EFA84816.1 - 0.089 12.3 0.1 7.9 6.0 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B FtsJ PF01728.19 EFA84817.1 - 1.6e-29 103.3 0.0 2.6e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Bromodomain PF00439.25 EFA84818.1 - 7.7e-09 35.5 0.0 2.8e-08 33.7 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Peptidase_M17 PF00883.21 EFA84819.1 - 1.7e-119 398.8 0.3 2.1e-119 398.4 0.3 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EFA84819.1 - 1.1e-18 67.3 0.0 2.3e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain PDZ_2 PF13180.6 EFA84819.1 - 0.15 12.4 0.2 0.63 10.4 0.0 2.1 2 0 0 2 2 2 0 PDZ domain Carb_bind PF10645.9 EFA84820.1 - 0.026 14.7 1.7 0.026 14.7 1.7 5.4 3 2 2 5 5 5 0 Carbohydrate binding LSM PF01423.22 EFA84821.1 - 3.6e-17 61.8 0.2 7.2e-17 60.8 0.2 1.5 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EFA84821.1 - 0.084 12.5 0.2 0.15 11.7 0.2 1.4 1 0 0 1 1 1 0 Hfq protein S-AdoMet_synt_N PF00438.20 EFA84821.1 - 0.12 13.1 0.1 0.18 12.5 0.1 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, N-terminal domain GST_C_3 PF14497.6 EFA84822.1 - 1.4e-16 60.4 0.0 5e-16 58.7 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA84822.1 - 6e-05 23.2 0.0 0.00014 22.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA84822.1 - 0.00024 21.4 0.0 0.00065 20.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF4853 PF16145.5 EFA84822.1 - 0.084 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) WD40 PF00400.32 EFA84823.1 - 2.2e-43 145.4 19.4 7.3e-08 33.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA84823.1 - 1.2e-13 51.1 0.6 0.00038 20.7 0.0 5.0 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 EFA84823.1 - 1.1e-12 47.3 2.3 1.1e-12 47.3 2.3 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Ge1_WD40 PF16529.5 EFA84823.1 - 5.2e-07 28.9 1.4 0.65 8.9 0.0 5.2 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein DSS1_SEM1 PF05160.13 EFA84824.1 - 1.6e-13 50.5 22.2 2e-13 50.2 22.0 1.3 1 1 0 1 1 1 1 DSS1/SEM1 family DNA_pol_E_B PF04042.16 EFA84825.1 - 1.1e-32 113.1 0.1 1.1e-32 113.1 0.1 1.9 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EFA84825.1 - 3.6e-29 101.5 0.0 1e-28 100.1 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Ank_4 PF13637.6 EFA84826.1 - 1.3e-24 86.2 19.3 2.3e-05 24.8 0.3 9.4 8 3 1 10 10 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84826.1 - 2.1e-21 76.3 13.2 5.4e-06 26.9 0.1 6.7 1 1 8 10 10 10 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA84826.1 - 2.7e-10 40.3 14.7 0.54 10.6 0.1 10.1 9 2 3 12 12 12 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84826.1 - 1.2e-08 34.5 12.9 16 6.5 0.0 11.6 12 2 2 14 14 13 1 Ankyrin repeat BUD22 PF09073.10 EFA84826.1 - 0.022 14.1 6.7 0.033 13.6 6.7 1.1 1 0 0 1 1 1 0 BUD22 Trans_reg_C PF00486.28 EFA84826.1 - 0.031 14.3 0.6 12 6.0 0.1 2.7 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal DUF5049 PF16468.5 EFA84826.1 - 0.2 11.6 2.9 6.2 6.8 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF5049) DNA_pol_phi PF04931.13 EFA84826.1 - 0.38 8.8 21.1 0.7 7.9 21.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EFA84826.1 - 0.63 9.4 10.2 0.93 8.9 10.2 1.2 1 0 0 1 1 1 0 SDA1 Ank PF00023.30 EFA84826.1 - 2.2 8.8 3.9 2.5e+02 2.4 0.3 5.3 4 2 0 4 4 4 0 Ankyrin repeat Nop14 PF04147.12 EFA84826.1 - 6.4 4.9 13.5 9.3 4.3 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family MARVEL PF01284.23 EFA84827.1 - 0.0091 16.0 8.0 0.053 13.5 7.3 2.4 2 1 0 2 2 2 1 Membrane-associating domain Cadherin_C_2 PF16492.5 EFA84827.1 - 0.14 13.0 2.4 5.5 7.8 0.3 2.6 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Amastin PF07344.11 EFA84827.1 - 0.74 9.6 8.4 1.5 8.6 8.4 1.6 1 1 0 1 1 1 0 Amastin surface glycoprotein DUF4306 PF14154.6 EFA84827.1 - 1.5 9.1 7.2 0.081 13.1 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4306) TMEM40 PF15817.5 EFA84827.1 - 4.3 7.1 5.6 6 6.7 4.4 1.9 1 1 0 1 1 1 0 Transmembrane protein 40 family Ank_4 PF13637.6 EFA84828.1 - 2e-12 47.4 4.0 0.00037 21.0 0.1 6.1 4 3 1 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84828.1 - 1.1e-11 45.2 3.6 0.00018 22.1 0.7 4.3 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84828.1 - 2.4e-11 42.8 1.1 0.42 11.3 0.0 6.8 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EFA84828.1 - 3.9e-09 36.6 3.2 0.027 14.8 0.1 5.2 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Methyltransf_11 PF08241.12 EFA84829.1 - 1e-17 64.6 0.0 2.1e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA84829.1 - 1.5e-16 60.9 0.0 3.1e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA84829.1 - 2.7e-13 50.5 0.3 1.8e-12 47.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA84829.1 - 5.4e-12 45.8 0.0 1.2e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA84829.1 - 9.9e-10 38.5 0.0 2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA84829.1 - 4.8e-07 29.4 0.0 9.3e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EFA84829.1 - 5.6e-07 28.8 0.0 1.1e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 EFA84829.1 - 6.7e-05 22.5 0.0 0.00017 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EFA84829.1 - 0.00013 21.9 0.2 0.00028 20.8 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 EFA84829.1 - 0.00022 20.7 0.0 0.00046 19.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EFA84829.1 - 0.0021 18.2 0.0 0.0044 17.2 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 EFA84829.1 - 0.0022 17.4 0.0 0.0049 16.2 0.0 1.6 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 EFA84829.1 - 0.0046 16.4 0.5 0.012 15.1 0.0 1.8 2 0 0 2 2 2 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EFA84829.1 - 0.0079 16.2 0.2 0.024 14.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Flp_C PF05202.12 EFA84829.1 - 0.015 14.9 0.2 0.015 14.9 0.2 1.7 2 0 0 2 2 2 0 Recombinase Flp protein DUF4792 PF16040.5 EFA84829.1 - 0.052 13.4 0.1 0.21 11.5 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4792) SH3_1 PF00018.28 EFA84829.1 - 0.18 11.4 0.2 0.41 10.3 0.2 1.5 1 0 0 1 1 1 0 SH3 domain Asp_protease PF09668.10 EFA84830.1 - 3.6e-52 175.4 0.6 5.7e-52 174.7 0.6 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EFA84830.1 - 2.6e-20 72.8 0.1 7.2e-20 71.4 0.0 1.8 2 0 0 2 2 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 EFA84830.1 - 6.2e-10 38.7 0.8 1.1e-09 37.9 0.3 1.7 2 0 0 2 2 1 1 Ubiquitin family Asp_protease_2 PF13650.6 EFA84830.1 - 7.5e-09 36.1 0.0 1.7e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease UBA_4 PF14555.6 EFA84830.1 - 4.6e-07 29.5 0.1 2.5e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 UBA-like domain RVP_2 PF08284.11 EFA84830.1 - 9.1e-05 22.2 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease GerD PF17898.1 EFA84830.1 - 0.00023 21.1 0.7 0.00063 19.7 0.4 1.9 2 0 0 2 2 2 1 Spore germination GerD central core domain TBK1_ULD PF18396.1 EFA84830.1 - 0.00051 19.9 0.1 0.002 18.0 0.1 2.0 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain RVP PF00077.20 EFA84830.1 - 0.00064 20.0 0.0 0.0018 18.6 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA PF00627.31 EFA84830.1 - 0.0061 16.4 0.1 0.017 15.0 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_4 PF18036.1 EFA84830.1 - 0.025 14.6 0.3 2.4 8.3 0.1 3.2 2 1 0 2 2 2 0 Ubiquitin-like domain DUF4179 PF13786.6 EFA84830.1 - 0.049 14.1 0.1 5 7.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) UN_NPL4 PF11543.8 EFA84830.1 - 0.053 14.0 0.5 0.18 12.3 0.2 2.1 2 0 0 2 2 1 0 Nuclear pore localisation protein NPL4 MetOD2 PF18548.1 EFA84830.1 - 0.057 13.5 1.1 0.26 11.4 0.3 2.5 3 0 0 3 3 2 0 Metanogen output domain 2 Rad60-SLD PF11976.8 EFA84830.1 - 0.12 12.2 0.2 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2884 PF11101.8 EFA84830.1 - 0.14 11.6 5.5 0.28 10.6 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2884) Med13_C PF06333.12 EFA84830.1 - 0.23 10.7 7.0 0.13 11.5 2.1 2.1 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain MSA-2c PF12238.8 EFA84830.1 - 1.8 8.6 10.0 0.8 9.7 7.0 1.9 2 0 0 2 2 2 0 Merozoite surface antigen 2c TFIIA PF03153.13 EFA84830.1 - 3.9 7.4 11.5 3.5 7.5 7.0 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 EFA84830.1 - 9 6.9 14.7 0.71 10.5 2.0 2.6 3 0 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Formyl_trans_N PF00551.19 EFA84831.1 - 6.3e-24 84.7 0.0 1.1e-23 83.9 0.0 1.5 1 1 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EFA84831.1 - 5.7e-06 26.5 0.0 1.6e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Formyl transferase, C-terminal domain THF_DHG_CYH_C PF02882.19 EFA84832.1 - 1.5e-42 144.6 0.0 5.2e-42 142.9 0.0 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EFA84832.1 - 5.9e-31 107.1 0.4 1.6e-30 105.8 0.2 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain TIG PF01833.24 EFA84832.1 - 3.6e-08 33.4 23.4 0.0008 19.4 0.4 7.3 6 1 0 6 6 6 3 IPT/TIG domain ISP3_C PF18045.1 EFA84832.1 - 0.0075 16.1 0.3 0.05 13.5 0.3 2.2 2 0 0 2 2 2 1 ISP3 C-terminal ISP1_C PF18161.1 EFA84832.1 - 0.022 14.7 0.2 0.07 13.1 0.2 1.8 1 0 0 1 1 1 0 ISP1 C-terminal EB PF01683.18 EFA84832.1 - 0.024 14.9 5.9 0.062 13.6 5.9 1.7 1 0 0 1 1 1 0 EB module hEGF PF12661.7 EFA84832.1 - 0.28 11.9 4.8 1 10.1 4.8 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 EFA84832.1 - 2.4 8.5 8.8 7.4 7.0 8.8 1.8 1 0 0 1 1 1 0 EGF-like domain Cpn60_TCP1 PF00118.24 EFA84833.1 - 2.6e-168 560.7 10.8 3e-168 560.5 10.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NUDIX PF00293.28 EFA84834.1 - 9.4e-13 48.3 0.0 2.5e-12 47.0 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain Baculo_IE-1 PF05290.11 EFA84834.1 - 0.0015 18.5 1.2 0.0042 17.0 0.6 2.0 1 1 1 2 2 2 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 EFA84834.1 - 0.034 14.0 2.2 3.5 7.5 0.7 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF2367 PF10164.9 EFA84834.1 - 0.062 13.8 0.2 0.062 13.8 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) zf-C3HC4_3 PF13920.6 EFA84834.1 - 0.077 12.9 5.5 0.47 10.3 0.3 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF2887 PF11103.8 EFA84834.1 - 0.081 12.9 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) zf-Di19 PF05605.12 EFA84834.1 - 0.38 11.1 8.9 1.4 9.3 8.9 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_2 PF13639.6 EFA84834.1 - 2.1 8.7 7.6 7.7 6.9 7.6 1.9 1 1 1 2 2 2 0 Ring finger domain DUF3611 PF12263.8 EFA84835.1 - 9.4 6.1 6.6 19 5.1 2.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3611) DUF4386 PF14329.6 EFA84836.1 - 0.012 15.5 1.8 0.021 14.7 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4386) DUF4149 PF13664.6 EFA84836.1 - 0.019 15.3 4.4 5.2 7.5 0.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) LPG_synthase_TM PF03706.13 EFA84836.1 - 0.026 14.1 0.2 0.026 14.1 0.2 1.6 2 0 0 2 2 2 0 Lysylphosphatidylglycerol synthase TM region InaF-motif PF15018.6 EFA84836.1 - 0.31 11.0 7.0 1.2 9.1 7.0 2.0 1 0 0 1 1 1 0 TRP-interacting helix DUF1422 PF07226.11 EFA84836.1 - 1.5 8.9 9.5 0.77 9.8 1.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1422) zf-CCHC PF00098.23 EFA84837.1 - 0.00031 20.7 1.6 0.00049 20.1 1.6 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EFA84837.1 - 0.012 15.5 0.3 0.012 15.5 0.3 2.3 2 0 0 2 2 2 0 Zinc knuckle NCKAP5 PF15246.6 EFA84837.1 - 3.1 7.3 24.8 0.013 15.1 8.9 2.1 2 0 0 2 2 2 0 Nck-associated protein 5, Peripheral clock protein Hydrolase_4 PF12146.8 EFA84838.1 - 1.1e-66 224.5 0.0 1.7e-66 223.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA84838.1 - 3.2e-11 44.3 0.0 8.7e-11 42.8 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA84838.1 - 4.6e-11 42.8 0.3 4.4e-09 36.4 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA84838.1 - 3.8e-06 26.5 0.1 0.014 14.9 0.1 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 EFA84838.1 - 0.0038 16.0 0.1 0.036 12.8 0.0 2.2 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Esterase PF00756.20 EFA84838.1 - 0.035 13.7 0.0 0.12 12.0 0.0 1.9 1 0 0 1 1 1 0 Putative esterase DUF3439 PF11921.8 EFA84838.1 - 0.12 12.3 4.0 0.38 10.7 4.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Thioesterase PF00975.20 EFA84838.1 - 0.14 12.3 0.2 0.29 11.2 0.2 1.5 1 0 0 1 1 1 0 Thioesterase domain Coilin_N PF15862.5 EFA84838.1 - 3.3 7.5 8.0 9.4 6.0 8.0 1.8 1 0 0 1 1 1 0 Coilin N-terminus RhoGAP PF00620.27 EFA84839.1 - 3.4e-47 160.1 1.0 9.6e-47 158.6 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 EFA84839.1 - 1.3e-37 129.0 2.3 1.3e-37 129.0 2.3 1.9 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Myb_DNA-binding PF00249.31 EFA84839.1 - 1.2e-15 57.4 0.1 1.9e-06 28.0 0.0 3.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain CRAL_TRIO PF00650.20 EFA84839.1 - 2.2e-12 47.0 1.2 6e-12 45.6 1.2 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain Myb_DNA-bind_6 PF13921.6 EFA84839.1 - 1.2e-08 35.1 4.3 0.003 17.8 0.0 4.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain ADP_PFK_GK PF04587.15 EFA84840.1 - 3.5e-134 447.6 0.4 4.1e-134 447.3 0.4 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region N_NLPC_P60 PF12912.7 EFA84840.1 - 0.079 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 NLPC_P60 stabilising domain, N term LPD11 PF18824.1 EFA84840.1 - 0.096 12.8 0.1 39 4.4 0.0 3.3 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 Orf78 PF06024.12 EFA84840.1 - 0.55 10.6 3.9 0.32 11.3 1.3 1.9 2 0 0 2 2 2 0 Orf78 (ac78) PfkB PF00294.24 EFA84840.1 - 1.2 8.3 3.5 0.61 9.3 0.1 2.1 3 0 0 3 3 3 0 pfkB family carbohydrate kinase Methyltransf_12 PF08242.12 EFA84840.1 - 1.5 9.6 4.7 8.1 7.3 0.0 3.3 3 0 0 3 3 3 0 Methyltransferase domain ABC2_membrane_3 PF12698.7 EFA84840.1 - 1.9 7.5 9.6 1.3 8.1 4.7 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein GBP PF02263.19 EFA84841.1 - 1e-32 113.5 0.5 1.3e-32 113.1 0.5 1.0 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain RHD3 PF05879.12 EFA84841.1 - 0.00053 18.3 0.1 0.00065 18.0 0.1 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EFA84841.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFA84841.1 - 0.0022 18.0 0.1 0.031 14.3 0.0 2.1 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 EFA84841.1 - 0.016 14.8 0.2 0.027 14.0 0.2 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B Peptidase_S46 PF10459.9 EFA84842.1 - 0.0035 16.1 1.7 0.0038 15.9 1.7 1.2 1 0 0 1 1 1 1 Peptidase S46 DrrA_P4M PF14860.6 EFA84842.1 - 0.46 10.4 6.2 0.59 10.0 0.0 3.6 2 1 0 3 3 3 0 DrrA phosphatidylinositol 4-phosphate binding domain SUZ PF12752.7 EFA84843.1 - 1.3e-12 48.3 0.4 1.3e-12 48.3 0.4 5.0 5 1 0 5 5 5 1 SUZ domain Pkinase PF00069.25 EFA84844.1 - 2.3e-63 214.0 2.3 2.3e-63 214.0 2.3 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA84844.1 - 7.7e-42 143.4 1.2 1.8e-41 142.2 1.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA84844.1 - 0.00042 20.3 0.1 0.1 12.5 0.0 3.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA84844.1 - 0.016 14.5 0.1 0.016 14.5 0.1 2.4 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3552 PF12072.8 EFA84844.1 - 1.1 8.7 11.4 0.097 12.1 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Haspin_kinase PF12330.8 EFA84844.1 - 3.3 6.5 18.8 26 3.6 18.9 2.4 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EFA84844.1 - 3.6 6.3 16.2 26 3.4 16.2 2.5 1 1 0 1 1 1 0 Fungal protein kinase SurA_N_3 PF13624.6 EFA84844.1 - 9.4 6.0 15.6 3 7.6 2.4 2.4 2 0 0 2 2 2 0 SurA N-terminal domain PK PF00224.21 EFA84845.1 - 1e-127 425.8 15.0 1.3e-85 287.4 11.2 3.1 1 1 1 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 EFA84845.1 - 5.3e-28 97.6 0.3 1.3e-27 96.4 0.3 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain Abhydrolase_6 PF12697.7 EFA84845.1 - 2.4e-24 87.2 0.0 3.4e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFA84845.1 - 5e-09 35.8 0.2 9.2e-09 34.9 0.2 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFA84845.1 - 3.1e-08 33.6 0.1 7.9e-08 32.3 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.14 EFA84845.1 - 0.00047 19.7 0.2 0.00083 18.9 0.2 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EFA84845.1 - 0.0018 18.1 0.3 0.006 16.5 0.3 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EFA84845.1 - 0.0027 16.7 0.1 0.0072 15.3 0.1 1.7 1 0 0 1 1 1 1 Chlorophyllase enzyme PGAP1 PF07819.13 EFA84845.1 - 0.0039 17.0 0.1 0.0071 16.1 0.1 1.4 1 0 0 1 1 1 1 PGAP1-like protein HpcH_HpaI PF03328.14 EFA84845.1 - 0.0048 16.1 0.6 0.011 14.9 0.6 1.5 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Lipase_3 PF01764.25 EFA84845.1 - 0.029 14.2 0.1 0.068 13.0 0.1 1.6 1 0 0 1 1 1 0 Lipase (class 3) Lipase_2 PF01674.18 EFA84845.1 - 0.037 13.6 0.1 0.074 12.6 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 2) Cutinase PF01083.22 EFA84845.1 - 0.064 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Cutinase DLH PF01738.18 EFA84845.1 - 0.071 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF900 PF05990.12 EFA84845.1 - 0.082 12.4 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Thioesterase PF00975.20 EFA84845.1 - 0.12 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain DUF5389 PF17364.2 EFA84846.1 - 0.0028 17.7 0.1 0.0035 17.4 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5389) DUF3810 PF12725.7 EFA84846.1 - 2.8 7.2 4.1 3.6 6.8 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Sulfate_transp PF00916.20 EFA84847.1 - 9.1e-99 330.8 28.1 2e-98 329.7 28.1 1.6 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFA84847.1 - 6.3e-15 54.8 0.0 1.3e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFA84847.1 - 0.0093 16.4 4.3 0.0093 16.4 4.3 3.4 2 1 1 3 3 3 1 Molybdate transporter of MFS superfamily DUF971 PF06155.12 EFA84849.1 - 9e-27 93.6 0.0 1.2e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF971) Ferrochelatase PF00762.19 EFA84850.1 - 0.019 14.0 0.1 0.022 13.8 0.1 1.1 1 0 0 1 1 1 0 Ferrochelatase EamA PF00892.20 EFA84851.1 - 9.3e-06 25.9 10.7 8.1e-05 22.8 5.0 2.1 1 1 1 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EFA84851.1 - 0.0018 17.5 1.4 0.028 13.6 0.1 2.0 1 1 1 2 2 2 2 Nucleotide-sugar transporter TMEM234 PF10639.9 EFA84851.1 - 0.0034 17.4 0.8 0.0051 16.8 0.8 1.6 1 1 0 1 1 1 1 Putative transmembrane family 234 DUF4064 PF13273.6 EFA84851.1 - 0.025 14.8 5.1 0.077 13.3 5.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) Cdc13_OB2 PF18691.1 EFA84851.1 - 0.067 13.3 0.0 0.16 12.0 0.0 1.6 2 0 0 2 2 2 0 Cell division control protein 13, OB2 domain UAA PF08449.11 EFA84851.1 - 0.095 11.9 4.4 0.085 12.0 2.9 1.3 1 1 0 1 1 1 0 UAA transporter family MCM PF00493.23 EFA84853.1 - 1.8e-94 315.0 0.0 2.8e-94 314.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFA84853.1 - 3e-32 111.1 0.2 5.8e-32 110.2 0.2 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFA84853.1 - 8.5e-24 83.8 0.3 2.2e-23 82.4 0.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFA84853.1 - 4.3e-08 32.8 0.0 1.5e-06 27.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EFA84853.1 - 8.2e-06 26.3 1.7 2.5e-05 24.8 1.7 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Sigma54_activat PF00158.26 EFA84853.1 - 0.005 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EFA84853.1 - 0.013 15.4 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Presenilin PF01080.17 EFA84853.1 - 0.38 9.5 13.7 0.7 8.6 13.7 1.3 1 0 0 1 1 1 0 Presenilin AAA_5 PF07728.14 EFA84854.1 - 3.9e-120 396.2 0.5 6.4e-22 78.0 0.0 10.2 8 1 1 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EFA84854.1 - 5.1e-56 187.4 4.9 1.4e-17 63.8 0.3 6.8 6 0 0 6 6 6 4 Midasin AAA lid domain AAA_lid_5 PF17865.1 EFA84854.1 - 5.9e-30 103.5 1.4 3.1e-29 101.1 0.0 3.2 4 0 0 4 4 1 1 Midasin AAA lid domain AAA_3 PF07726.11 EFA84854.1 - 1.8e-29 102.3 0.0 6.1e-11 42.3 0.0 6.8 6 0 0 6 6 6 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFA84854.1 - 4.9e-22 78.3 12.1 4e-06 26.5 0.2 6.8 6 0 0 6 6 6 5 P-loop containing dynein motor region AAA PF00004.29 EFA84854.1 - 1.7e-21 77.0 0.7 0.00022 21.6 0.0 8.0 7 0 0 7 7 7 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFA84854.1 - 1.1e-20 74.7 18.3 6.2e-05 23.4 0.0 9.1 7 2 1 8 8 7 5 AAA ATPase domain Dynein_heavy PF03028.15 EFA84854.1 - 2.2e-20 73.0 0.0 0.096 12.8 0.0 7.8 7 0 0 7 7 6 5 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 EFA84854.1 - 1.3e-14 54.6 3.1 0.0094 16.2 0.0 7.2 7 0 0 7 7 5 4 AAA domain Sigma54_activat PF00158.26 EFA84854.1 - 2.4e-13 50.2 0.0 0.048 13.4 0.0 5.7 5 0 0 5 5 5 3 Sigma-54 interaction domain AAA_14 PF13173.6 EFA84854.1 - 1.9e-12 47.4 10.4 0.013 15.5 0.0 8.0 8 1 0 9 9 7 3 AAA domain AAA_18 PF13238.6 EFA84854.1 - 2.1e-12 47.7 2.8 0.41 11.2 0.0 7.3 5 0 0 5 5 5 3 AAA domain TsaE PF02367.17 EFA84854.1 - 7e-11 42.2 3.9 0.29 11.2 0.0 6.1 5 0 0 5 5 5 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EFA84854.1 - 1.1e-10 41.2 0.4 0.013 14.8 0.0 4.9 5 0 0 5 5 4 3 Zeta toxin T2SSE PF00437.20 EFA84854.1 - 3e-10 39.6 9.1 0.0093 15.1 0.0 6.6 6 0 0 6 6 6 2 Type II/IV secretion system protein AAA_6 PF12774.7 EFA84854.1 - 1.3e-09 37.5 6.5 0.32 9.9 0.0 8.5 8 1 0 8 8 7 2 Hydrolytic ATP binding site of dynein motor region AAA_30 PF13604.6 EFA84854.1 - 3.2e-09 36.8 0.0 0.093 12.4 0.0 6.0 6 0 0 6 6 6 1 AAA domain AAA_33 PF13671.6 EFA84854.1 - 3.8e-08 33.6 0.0 1.6 8.9 0.0 5.6 4 0 0 4 4 4 2 AAA domain NACHT PF05729.12 EFA84854.1 - 2.4e-07 30.8 0.8 1.2 9.1 0.1 5.4 5 0 0 5 5 5 2 NACHT domain RNA_helicase PF00910.22 EFA84854.1 - 2.8e-07 30.9 0.3 0.93 9.9 0.0 6.3 5 0 0 5 5 5 1 RNA helicase RsgA_GTPase PF03193.16 EFA84854.1 - 1.3e-06 28.4 8.8 0.23 11.3 0.9 5.3 5 0 0 5 5 4 3 RsgA GTPase AAA_28 PF13521.6 EFA84854.1 - 3e-06 27.6 6.4 1.3 9.3 0.1 6.3 6 0 0 6 6 6 1 AAA domain Mg_chelatase PF01078.21 EFA84854.1 - 1.8e-05 24.2 1.4 5.8 6.2 0.1 7.0 9 0 0 9 9 8 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EFA84854.1 - 2.4e-05 24.7 1.0 2.6 8.4 0.0 5.7 5 0 0 5 5 4 1 AAA domain AAA_29 PF13555.6 EFA84854.1 - 3.1e-05 23.6 2.3 12 5.7 0.0 5.3 5 0 0 5 5 5 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 EFA84854.1 - 3.7e-05 23.5 3.9 6.1 6.6 0.0 5.5 5 0 0 5 5 5 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activ_2 PF14532.6 EFA84854.1 - 8.2e-05 22.7 8.1 0.28 11.3 0.0 5.5 6 0 0 6 6 4 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 EFA84854.1 - 8.7e-05 22.3 1.5 0.99 9.1 0.0 4.7 5 0 0 5 5 4 1 IstB-like ATP binding protein SRP54 PF00448.22 EFA84854.1 - 9e-05 22.2 3.1 0.67 9.5 0.1 5.0 5 0 0 5 5 4 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EFA84854.1 - 0.00016 22.2 32.2 0.037 14.5 0.0 8.8 8 1 0 8 8 6 2 ABC transporter RuvB_N PF05496.12 EFA84854.1 - 0.00027 20.7 3.7 1.7 8.4 0.0 5.9 7 0 0 7 7 6 1 Holliday junction DNA helicase RuvB P-loop domain cobW PF02492.19 EFA84854.1 - 0.0004 20.0 1.6 2.9 7.5 0.1 4.2 4 0 0 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 EFA84854.1 - 0.0014 18.4 0.0 6.4 6.4 0.0 4.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Roc PF08477.13 EFA84854.1 - 0.0026 17.9 6.3 12 6.2 0.0 6.8 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA84854.1 - 0.0089 16.1 4.4 12 6.1 0.1 5.7 6 0 0 6 6 4 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 EFA84854.1 - 0.045 13.7 4.6 9 6.2 0.1 4.4 4 0 0 4 4 4 0 NTPase CPT PF07931.12 EFA84854.1 - 0.24 11.2 4.1 16 5.3 0.0 5.1 6 1 0 6 6 4 0 Chloramphenicol phosphotransferase-like protein UQ_con PF00179.26 EFA84855.1 - 4.1e-53 178.8 0.0 4.8e-53 178.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFA84855.1 - 0.00047 19.9 0.0 0.00059 19.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFA84855.1 - 0.0061 16.8 0.5 0.017 15.4 0.4 1.7 1 1 0 1 1 1 1 RWD domain Xpo1 PF08389.12 EFA84859.1 - 0.0019 18.3 3.6 0.0032 17.6 3.1 1.7 1 1 0 1 1 1 1 Exportin 1-like protein PT PF04886.12 EFA84860.1 - 0.0015 18.0 3.8 0.0015 18.0 3.8 10.5 9 2 2 11 11 11 6 PT repeat 4HBT_2 PF13279.6 EFA84860.1 - 0.015 15.8 0.0 0.17 12.4 0.0 2.7 2 0 0 2 2 2 0 Thioesterase-like superfamily DUF3439 PF11921.8 EFA84860.1 - 0.32 11.0 21.4 0.058 13.4 13.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 EFA84860.1 - 0.35 9.0 14.4 0.67 8.1 14.4 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Amastin PF07344.11 EFA84861.1 - 0.0001 22.2 6.2 0.00087 19.2 6.2 2.0 1 1 0 1 1 1 1 Amastin surface glycoprotein Ninjurin PF04923.12 EFA84861.1 - 0.14 12.1 2.7 0.36 10.8 0.1 2.3 2 1 0 2 2 2 0 Ninjurin DHHC PF01529.20 EFA84861.1 - 0.44 10.6 4.7 4.9 7.3 1.9 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase ECSCR PF15820.5 EFA84861.1 - 0.47 10.3 11.7 3.2 7.6 0.0 3.2 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator DUF2207 PF09972.9 EFA84861.1 - 1.9 7.1 11.8 0.039 12.7 3.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) TMEM154 PF15102.6 EFA84861.1 - 2.9 7.8 6.8 0.66 9.9 0.1 2.6 2 1 1 3 3 3 0 TMEM154 protein family SUR7 PF06687.12 EFA84861.1 - 2.9 7.5 13.3 0.36 10.4 8.3 2.1 1 1 1 2 2 2 0 SUR7/PalI family DUF1218 PF06749.12 EFA84861.1 - 9.7 6.8 9.2 1.1 9.8 0.3 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1218) Rad52_Rad22 PF04098.15 EFA84862.1 - 3.5e-44 150.4 0.0 3.5e-44 150.4 0.0 1.9 1 1 1 2 2 2 1 Rad52/22 family double-strand break repair protein CCDC53 PF10152.9 EFA84862.1 - 0.0075 16.7 5.0 0.0095 16.4 5.0 1.2 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Pex14_N PF04695.13 EFA84862.1 - 0.043 14.5 19.7 0.068 13.8 19.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 EFA84862.1 - 0.054 13.5 22.7 0.07 13.1 22.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM214 PF10151.9 EFA84862.1 - 0.059 11.8 10.1 0.077 11.4 10.1 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Neur_chan_memb PF02932.16 EFA84862.1 - 0.18 11.8 1.7 0.17 11.9 1.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Suf PF05843.14 EFA84862.1 - 0.38 10.7 9.7 0.5 10.3 9.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1980 PF09323.10 EFA84862.1 - 3.9 7.4 6.6 5.7 6.8 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Presenilin PF01080.17 EFA84862.1 - 3.9 6.1 9.1 5.4 5.7 9.1 1.2 1 0 0 1 1 1 0 Presenilin Proteasome PF00227.26 EFA84863.1 - 6.9e-49 165.9 0.7 8.2e-49 165.7 0.7 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EFA84863.1 - 8.9e-06 25.0 1.6 2.6e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 Proteasome beta subunits C terminal SKI PF01202.22 EFA84864.1 - 2.4e-12 47.2 0.0 3e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 EFA84864.1 - 0.0001 22.9 0.0 0.00022 21.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFA84864.1 - 0.00028 21.0 0.0 0.0018 18.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EFA84864.1 - 0.0073 16.2 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase DUF2075 PF09848.9 EFA84864.1 - 0.015 14.5 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) dNK PF01712.19 EFA84864.1 - 0.065 13.1 0.0 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_22 PF13401.6 EFA84864.1 - 0.12 12.7 0.0 0.53 10.6 0.0 2.0 2 1 0 2 2 2 0 AAA domain Trm112p PF03966.16 EFA84864.1 - 0.12 13.0 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 Trm112p-like protein Cytidylate_kin PF02224.18 EFA84864.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_16 PF13191.6 EFA84864.1 - 0.15 12.4 1.0 0.3 11.4 0.7 1.7 1 1 1 2 2 2 0 AAA ATPase domain CDC45 PF02724.14 EFA84866.1 - 0.53 8.5 3.3 0.76 8.0 3.3 1.2 1 0 0 1 1 1 0 CDC45-like protein CDC45 PF02724.14 EFA84867.1 - 0.041 12.2 0.4 0.063 11.6 0.4 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4685 PF15737.5 EFA84867.1 - 0.17 12.3 2.1 0.32 11.5 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4685) CENP-B_dimeris PF09026.10 EFA84867.1 - 4.5 7.7 12.4 9.6 6.7 12.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain A_deaminase PF00962.22 EFA84868.1 - 1.2e-27 97.2 0.0 2.4e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 EFA84868.1 - 9.1e-14 51.5 0.1 1.7e-13 50.6 0.1 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal Transthyretin PF00576.21 EFA84869.1 - 3.3e-35 121.1 0.2 3.7e-35 120.9 0.2 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family SdrD_B PF17210.3 EFA84869.1 - 0.036 14.3 0.1 0.052 13.8 0.1 1.3 1 0 0 1 1 1 0 SdrD B-like domain phage_tail_N PF08400.10 EFA84869.1 - 0.089 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Prophage tail fibre N-terminal Acetyltransf_3 PF13302.7 EFA84870.1 - 1.6e-21 77.4 0.1 2.3e-21 76.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFA84870.1 - 3.6e-09 36.5 0.2 7.4e-07 28.9 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA84870.1 - 6.4e-08 32.8 0.1 1.1e-07 32.0 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFA84870.1 - 1.5e-07 31.3 0.0 2.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFA84870.1 - 3.8e-06 27.1 1.2 8e-06 26.1 1.2 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA84870.1 - 0.0007 19.5 0.1 0.0017 18.3 0.0 1.7 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA84870.1 - 0.0012 19.2 0.0 0.0025 18.2 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF2652 PF10851.8 EFA84870.1 - 0.055 13.6 0.2 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2652) tRNA_SAD PF07973.14 EFA84871.1 - 0.0027 17.8 0.0 0.0051 16.9 0.0 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Fra10Ac1 PF09725.9 EFA84872.1 - 6.4e-30 103.8 1.4 1e-29 103.1 1.4 1.4 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 GTP1_OBG PF01018.22 EFA84873.1 - 2.6e-42 144.0 13.0 9.3e-29 100.0 4.5 2.5 3 0 0 3 3 3 2 GTP1/OBG MMR_HSR1 PF01926.23 EFA84873.1 - 3.7e-20 72.1 0.0 8.9e-20 70.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA84873.1 - 3.4e-05 23.4 0.0 0.00017 21.1 0.0 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFA84873.1 - 0.0029 17.7 1.7 0.25 11.4 1.7 3.2 1 1 0 1 1 1 1 Dynamin family Arf PF00025.21 EFA84873.1 - 0.018 14.5 0.1 2.5 7.5 0.0 2.5 3 0 0 3 3 3 0 ADP-ribosylation factor family PIN_12 PF16289.5 EFA84873.1 - 0.032 14.7 0.6 0.07 13.6 0.6 1.5 1 0 0 1 1 1 0 PIN domain AAA_18 PF13238.6 EFA84873.1 - 0.092 13.3 0.0 0.36 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EFA84873.1 - 0.11 11.5 0.1 0.72 8.8 0.0 2.2 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Lambda_CIII PF02061.16 EFA84873.1 - 0.33 11.0 0.8 16 5.7 0.4 2.5 2 0 0 2 2 2 0 Lambda Phage CIII Metallophos PF00149.28 EFA84874.1 - 2.1e-32 113.3 11.6 2.2e-16 61.0 1.5 2.5 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glucosamine_iso PF01182.20 EFA84875.1 - 1.9e-17 63.9 0.0 1.4e-11 44.8 0.0 2.2 2 0 0 2 2 2 2 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PIG-L PF02585.17 EFA84875.1 - 3.3e-17 63.4 0.0 7.2e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Tubulin PF00091.25 EFA84877.1 - 1.9e-30 106.5 0.1 2.6e-30 106.1 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 EFA84877.1 - 1.1e-07 32.1 0.0 2.6e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.6 EFA84877.1 - 7.6e-05 22.1 3.4 0.028 13.6 0.3 3.0 2 1 1 3 3 3 2 Tubulin like Ank_4 PF13637.6 EFA84878.1 - 3.8e-25 87.9 4.3 4e-05 24.1 0.0 6.3 5 2 1 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84878.1 - 3.8e-20 71.7 7.9 0.0012 19.1 0.1 8.4 3 1 6 9 9 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84878.1 - 9e-20 71.1 2.7 1.2e-08 35.5 0.1 4.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84878.1 - 1.5e-15 55.7 4.4 1.5 9.6 0.0 8.9 7 2 2 9 9 9 4 Ankyrin repeat DUF5049 PF16468.5 EFA84878.1 - 0.00032 20.5 0.7 1.2 9.1 0.1 5.0 4 2 1 5 5 5 1 Domain of unknown function (DUF5049) Ank PF00023.30 EFA84878.1 - 0.062 13.8 1.0 22 5.7 0.0 4.8 4 2 0 4 4 4 0 Ankyrin repeat Trimer_CC PF08954.11 EFA84878.1 - 0.071 12.7 0.3 0.17 11.5 0.3 1.6 1 0 0 1 1 1 0 Trimerisation motif Glyco_trans_4_5 PF16994.5 EFA84878.1 - 0.11 12.1 6.1 11 5.6 0.0 4.2 2 1 2 4 4 4 0 Glycosyl-transferase family 4 Sec16 PF12932.7 EFA84878.1 - 0.13 12.8 3.5 7.2 7.2 1.6 3.7 2 1 1 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region HTH_28 PF13518.6 EFA84878.1 - 0.16 12.1 0.6 12 6.1 0.0 3.8 4 1 0 4 4 4 0 Helix-turn-helix domain Kelch_6 PF13964.6 EFA84879.1 - 1.6e-21 75.7 8.6 0.00064 19.9 0.0 5.5 3 2 2 5 5 5 5 Kelch motif Kelch_1 PF01344.25 EFA84879.1 - 4.7e-17 61.3 11.1 1.4e-06 27.7 0.1 5.4 5 1 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EFA84879.1 - 1.4e-14 53.8 11.9 0.0018 18.2 0.1 6.3 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA84879.1 - 2.7e-07 30.3 5.5 0.0015 18.4 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 EFA84879.1 - 0.00016 21.6 11.4 0.5 10.4 0.2 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFA84879.1 - 0.0014 18.9 2.8 6.7 7.1 0.0 5.4 5 1 0 5 5 5 1 Galactose oxidase, central domain AsiA PF09010.10 EFA84879.1 - 0.096 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Anti-Sigma Factor A DUF1084 PF06454.11 EFA84880.1 - 1.5e-08 34.4 1.6 2.5e-08 33.7 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) RRM_1 PF00076.22 EFA84881.1 - 1.7e-15 56.5 0.0 3.5e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EFA84881.1 - 7.7e-08 32.1 2.1 2.4e-07 30.5 2.1 2.0 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 EFA84881.1 - 2.3e-07 30.5 0.0 4.6e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_2 PF13696.6 EFA84881.1 - 0.0004 20.1 1.6 0.00083 19.1 1.6 1.6 1 0 0 1 1 1 1 Zinc knuckle EF-hand_6 PF13405.6 EFA84883.1 - 8.8e-06 25.3 0.1 3.9e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EFA84883.1 - 3e-05 23.3 0.5 0.00026 20.3 0.1 2.3 2 0 0 2 2 2 1 EF hand EFhand_Ca_insen PF08726.10 EFA84883.1 - 0.00016 21.7 1.8 0.00069 19.7 1.8 1.9 1 1 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_7 PF13499.6 EFA84883.1 - 0.0011 19.4 0.1 0.0026 18.2 0.1 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 EFA84883.1 - 0.018 15.3 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain Ank_2 PF12796.7 EFA84884.1 - 1.8e-44 150.2 28.2 1.9e-10 41.1 0.4 6.8 2 1 7 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84884.1 - 5.1e-32 109.8 6.4 5.1e-06 26.9 0.1 10.4 7 2 4 11 11 11 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA84884.1 - 1.7e-25 88.7 9.3 0.054 13.8 0.0 12.1 2 1 10 13 13 13 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84884.1 - 1.1e-21 74.6 2.1 0.023 15.2 0.0 13.2 10 3 4 14 14 14 3 Ankyrin repeat DUF5049 PF16468.5 EFA84884.1 - 7.8e-09 35.3 5.3 2.4 8.1 0.0 8.8 6 3 4 10 10 10 2 Domain of unknown function (DUF5049) Ank PF00023.30 EFA84884.1 - 0.00025 21.3 3.5 53 4.5 0.1 7.7 6 3 1 7 7 7 0 Ankyrin repeat DUF1820 PF08850.11 EFA84884.1 - 0.00031 21.2 0.1 1.1 9.8 0.0 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF1820) DUF1084 PF06454.11 EFA84885.1 - 4.2e-09 36.2 22.5 9e-05 22.0 0.8 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1084) SET PF00856.28 EFA84886.1 - 2.6e-10 40.9 15.7 9e-10 39.2 10.8 2.6 2 1 0 2 2 2 2 SET domain DUF3337 PF11816.8 EFA84886.1 - 0.01 15.7 0.4 0.01 15.7 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3337) zf-B_box PF00643.24 EFA84887.1 - 2.5e-06 27.5 9.5 5.4e-06 26.5 9.5 1.6 1 0 0 1 1 1 1 B-box zinc finger Apolipoprotein PF01442.18 EFA84887.1 - 0.021 14.7 2.7 0.033 14.0 2.7 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain YtxH PF12732.7 EFA84887.1 - 0.72 10.4 2.5 1.9 9.1 2.5 1.6 1 0 0 1 1 1 0 YtxH-like protein PBP1_TM PF14812.6 EFA84887.1 - 1.4 9.3 11.4 0.14 12.5 5.4 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF5427 PF10310.9 EFA84888.1 - 0.06 12.3 30.7 0.07 12.1 30.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SID-1_RNA_chan PF13965.6 EFA84888.1 - 0.22 9.9 12.8 0.25 9.7 12.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Velvet PF11754.8 EFA84888.1 - 0.37 10.7 25.0 0.44 10.4 25.0 1.2 1 0 0 1 1 1 0 Velvet factor Glyco_transf_41 PF13844.6 EFA84888.1 - 0.41 9.0 22.4 0.48 8.8 22.4 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 eIF-3_zeta PF05091.12 EFA84888.1 - 0.56 9.1 39.4 0.63 9.0 39.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Endostatin PF06482.11 EFA84888.1 - 0.61 9.5 27.6 0.76 9.2 27.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2126 PF09899.9 EFA84888.1 - 0.63 8.0 17.0 0.77 7.8 17.0 1.3 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) ALMT PF11744.8 EFA84888.1 - 0.74 8.6 28.5 0.81 8.5 28.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CSG2 PF16965.5 EFA84888.1 - 1.3 7.9 18.9 1.5 7.7 18.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Nop53 PF07767.11 EFA84888.1 - 1.6 8.0 41.7 2 7.7 41.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Neur_chan_memb PF02932.16 EFA84888.1 - 1.7 8.6 24.5 2.4 8.2 24.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 EFA84888.1 - 2.5 6.3 27.9 3.1 6.0 27.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.6 EFA84888.1 - 3.1 7.4 26.8 3.6 7.1 26.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) NPR3 PF03666.13 EFA84888.1 - 3.5 6.3 30.2 4.7 5.9 30.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2561 PF10812.8 EFA84888.1 - 3.5 7.6 5.7 4.3 7.3 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF2052 PF09747.9 EFA84888.1 - 4 7.5 35.3 5.1 7.2 35.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Rtf2 PF04641.12 EFA84888.1 - 4.3 6.6 28.7 5.6 6.2 28.7 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger XRN_M PF17846.1 EFA84888.1 - 4.8 6.0 24.8 6.2 5.7 24.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain AAA_11 PF13086.6 EFA84888.1 - 6.3 6.5 30.4 8.5 6.1 30.4 1.2 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.9 EFA84888.1 - 7.3 4.7 53.3 9.2 4.4 53.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 EFA84889.1 - 4.5e-05 22.4 12.0 4.5e-05 22.4 12.0 2.1 2 0 0 2 2 2 1 Presenilin TFIIA PF03153.13 EFA84889.1 - 4.8e-05 23.5 31.5 6.9e-05 23.0 31.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 EFA84889.1 - 0.0015 17.1 11.2 0.0026 16.3 11.2 1.4 1 0 0 1 1 1 1 Borrelia P83/100 protein Connexin PF00029.19 EFA84889.1 - 0.0016 18.3 10.9 0.003 17.3 10.9 1.5 1 0 0 1 1 1 1 Connexin Serinc PF03348.15 EFA84889.1 - 0.0017 17.3 5.8 0.0027 16.7 5.8 1.3 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF2828 PF11443.8 EFA84889.1 - 0.002 16.3 11.3 0.0073 14.5 10.9 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 EFA84889.1 - 0.0021 17.1 16.7 0.0031 16.6 16.7 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF913 PF06025.12 EFA84889.1 - 0.0061 15.6 6.1 0.0061 15.6 6.1 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) Velvet PF11754.8 EFA84889.1 - 0.013 15.4 16.9 0.025 14.5 16.9 1.4 1 0 0 1 1 1 0 Velvet factor Kei1 PF08552.11 EFA84889.1 - 0.014 15.3 6.0 0.026 14.4 6.0 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SprA-related PF12118.8 EFA84889.1 - 0.019 14.2 31.4 0.031 13.4 31.4 1.3 1 0 0 1 1 1 0 SprA-related family SpoIIP PF07454.11 EFA84889.1 - 0.021 14.3 17.0 0.037 13.5 17.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PBP1_TM PF14812.6 EFA84889.1 - 0.033 14.6 6.5 0.066 13.6 6.5 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2561 PF10812.8 EFA84889.1 - 0.033 14.2 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) PPP4R2 PF09184.11 EFA84889.1 - 0.047 13.3 11.8 0.078 12.6 11.8 1.4 1 0 0 1 1 1 0 PPP4R2 CCDC53 PF10152.9 EFA84889.1 - 0.047 14.1 15.3 0.088 13.2 15.3 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Afi1 PF07792.12 EFA84889.1 - 0.055 14.0 13.4 0.14 12.7 13.4 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PAT1 PF09770.9 EFA84889.1 - 0.056 11.7 27.0 0.081 11.2 27.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ORC_WH_C PF18137.1 EFA84889.1 - 0.057 13.5 9.6 0.12 12.5 9.6 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal FAM60A PF15396.6 EFA84889.1 - 0.11 12.5 10.7 0.22 11.5 10.7 1.5 1 0 0 1 1 1 0 Protein Family FAM60A Scs3p PF10261.9 EFA84889.1 - 0.11 12.0 5.7 0.23 10.9 5.7 1.5 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM FAM76 PF16046.5 EFA84889.1 - 0.11 11.8 17.9 0.23 10.8 17.9 1.4 1 0 0 1 1 1 0 FAM76 protein DUF4820 PF16091.5 EFA84889.1 - 0.12 11.8 12.1 0.35 10.2 12.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4746 PF15928.5 EFA84889.1 - 0.13 11.6 13.1 0.22 10.9 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pex14_N PF04695.13 EFA84889.1 - 0.15 12.7 27.7 0.27 11.9 27.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BORG_CEP PF14957.6 EFA84889.1 - 0.19 12.9 9.2 0.46 11.6 9.2 1.7 1 0 0 1 1 1 0 Cdc42 effector CPSF100_C PF13299.6 EFA84889.1 - 0.2 11.8 12.1 0.43 10.7 12.1 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal LRR_4 PF12799.7 EFA84889.1 - 0.22 12.0 10.3 2.5 8.7 2.6 4.3 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) DUF2370 PF10176.9 EFA84889.1 - 0.24 11.0 7.5 0.43 10.2 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CLN3 PF02487.17 EFA84889.1 - 0.26 10.3 20.3 0.21 10.6 18.1 1.9 1 1 1 2 2 2 0 CLN3 protein DUF4366 PF14283.6 EFA84889.1 - 0.4 10.7 8.7 0.73 9.9 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Ctr PF04145.15 EFA84889.1 - 0.51 10.9 9.7 1.2 9.8 9.7 1.5 1 0 0 1 1 1 0 Ctr copper transporter family Peptidase_U57 PF05582.12 EFA84889.1 - 0.6 9.3 12.7 1.2 8.3 12.7 1.5 1 0 0 1 1 1 0 YabG peptidase U57 LAP1C PF05609.12 EFA84889.1 - 0.6 9.1 18.4 0.87 8.6 18.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Spore_coat_CotO PF14153.6 EFA84889.1 - 0.63 9.9 26.4 1.5 8.7 26.4 1.6 1 0 0 1 1 1 0 Spore coat protein CotO Zip PF02535.22 EFA84889.1 - 0.74 9.0 6.2 1.4 8.1 6.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CAF1 PF04857.20 EFA84889.1 - 0.76 8.9 12.5 1.4 8.1 12.5 1.4 1 0 0 1 1 1 0 CAF1 family ribonuclease Ureide_permease PF07168.11 EFA84889.1 - 0.96 8.1 6.9 1.7 7.4 6.9 1.3 1 0 0 1 1 1 0 Ureide permease Gti1_Pac2 PF09729.9 EFA84889.1 - 1.3 9.1 16.7 2.9 7.9 16.7 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family SARAF PF06682.12 EFA84889.1 - 2.1 7.9 16.1 3.3 7.3 16.1 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis XRN_M PF17846.1 EFA84889.1 - 2.4 7.0 15.5 4.6 6.1 15.5 1.4 1 0 0 1 1 1 0 Xrn1 helical domain Paramyxo_ncap PF00973.19 EFA84889.1 - 3 6.7 12.6 4.5 6.1 12.6 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CDC45 PF02724.14 EFA84889.1 - 3.1 6.0 17.5 4.6 5.4 17.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EFA84889.1 - 3.2 7.5 22.1 5.4 6.8 22.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 EFA84889.1 - 4.5 6.5 13.8 8.3 5.6 13.8 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Nucleoside_tran PF01733.18 EFA84889.1 - 4.7 6.5 15.9 0.023 14.1 5.8 2.2 3 0 0 3 3 3 0 Nucleoside transporter TFB6 PF17110.5 EFA84889.1 - 4.9 6.9 10.9 14 5.4 10.9 1.8 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Peptidase_S15 PF02129.18 EFA84889.1 - 5.6 6.5 11.2 10 5.6 11.2 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) FAM176 PF14851.6 EFA84889.1 - 5.7 6.6 13.6 2.8 7.6 10.7 1.9 2 0 0 2 2 1 0 FAM176 family MMU163 PF17119.5 EFA84889.1 - 6 6.0 9.1 14 4.8 9.1 1.6 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis CobT PF06213.12 EFA84889.1 - 6.4 6.1 31.6 9.6 5.5 31.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tim54 PF11711.8 EFA84889.1 - 6.5 5.4 18.8 11 4.7 18.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 EPL1 PF10513.9 EFA84889.1 - 7.3 7.0 21.3 24 5.3 21.3 1.8 1 0 0 1 1 1 0 Enhancer of polycomb-like SAP PF02037.27 EFA84891.1 - 0.0002 21.0 0.0 0.00053 19.7 0.0 1.7 1 0 0 1 1 1 1 SAP domain Cwf_Cwc_15 PF04889.12 EFA84891.1 - 1.2 8.8 3.5 1.9 8.2 3.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Imm5 PF14423.6 EFA84892.1 - 0.072 13.3 0.1 0.084 13.1 0.1 1.2 1 0 0 1 1 1 0 Immunity protein Imm5 SAP PF02037.27 EFA84893.1 - 0.0032 17.2 0.2 0.0079 15.9 0.0 1.8 2 0 0 2 2 2 1 SAP domain DUF1108 PF06531.11 EFA84893.1 - 0.044 14.1 0.7 0.55 10.6 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1108) SAP PF02037.27 EFA84896.1 - 3.4e-05 23.5 0.1 7.6e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 SAP domain Rho_N PF07498.12 EFA84896.1 - 0.0065 16.4 0.9 0.018 14.9 0.9 1.8 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain LRR_4 PF12799.7 EFA84898.1 - 1.7 9.2 0.0 1.7 9.2 0.0 3.2 4 2 0 4 4 4 0 Leucine Rich repeats (2 copies) SAP PF02037.27 EFA84899.1 - 0.00023 20.9 0.1 0.00058 19.6 0.1 1.8 1 0 0 1 1 1 1 SAP domain LRR_6 PF13516.6 EFA84900.1 - 0.36 11.0 1.7 54 4.2 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Metallophos PF00149.28 EFA84901.1 - 6.3e-13 49.7 4.3 1.4e-12 48.6 4.3 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase A_deaminase PF00962.22 EFA84902.1 - 8e-25 87.8 0.0 1.4e-24 87.0 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 EFA84902.1 - 6.4e-11 42.4 0.2 1.3e-10 41.4 0.2 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal TPR_1 PF00515.28 EFA84904.1 - 0.036 13.9 1.4 9.9 6.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TAP42 PF04177.12 EFA84904.1 - 0.11 11.6 4.3 2.2 7.3 0.2 2.4 2 0 0 2 2 2 0 TAP42-like family INCENP_ARK-bind PF03941.15 EFA84904.1 - 0.13 12.2 0.1 32 4.6 0.0 2.8 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region DUF2877 PF11392.8 EFA84904.1 - 0.21 12.3 1.4 19 6.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) DUF4419 PF14388.6 EFA84905.1 - 4.1e-100 335.1 0.0 4.9e-100 334.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Suf PF05843.14 EFA84906.1 - 0.00092 19.3 4.2 0.0033 17.5 0.7 5.6 2 1 1 5 5 5 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EFA84906.1 - 0.15 12.6 0.0 28 5.3 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat HECT PF00632.25 EFA84907.1 - 5.6e-91 305.2 0.2 2.2e-90 303.3 0.1 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EFA84907.1 - 1.7e-13 50.6 2.4 3.7e-13 49.5 2.4 1.6 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Mucin PF01456.17 EFA84907.1 - 0.13 12.2 11.2 0.23 11.5 11.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EFA84907.1 - 3.7 5.6 11.0 5.4 5.1 11.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 zf-CCCH PF00642.24 EFA84908.1 - 0.037 13.9 6.2 0.26 11.3 3.8 2.9 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFA84908.1 - 2.4 8.3 10.1 1.9 8.6 3.5 3.2 2 0 0 2 2 2 0 Zinc finger domain Arf PF00025.21 EFA84909.1 - 0.00013 21.4 0.0 0.00013 21.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF4458 PF14660.6 EFA84910.1 - 0.035 14.4 0.2 0.035 14.4 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4458) Dus PF01207.17 EFA84911.1 - 0.0012 18.0 0.0 0.0014 17.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DDE_Tnp_4 PF13359.6 EFA84913.1 - 4.4e-16 58.9 0.4 7.7e-16 58.2 0.1 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-C2H2_2 PF12756.7 EFA84913.1 - 0.03 14.6 0.4 1.1 9.7 0.0 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Nuc_deoxyri_tr2 PF15891.5 EFA84913.1 - 0.16 12.3 0.0 0.49 10.7 0.1 1.8 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like zf-C2H2_4 PF13894.6 EFA84913.1 - 5.7 8.1 8.8 4.5 8.4 1.9 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger SAP PF02037.27 EFA84915.1 - 0.0057 16.4 0.1 0.013 15.2 0.1 1.7 1 0 0 1 1 1 1 SAP domain Rho_N PF07498.12 EFA84915.1 - 1.4 8.9 6.3 2.3 8.2 0.7 2.6 1 1 1 2 2 2 0 Rho termination factor, N-terminal domain Aquarius_N PF16399.5 EFA84916.1 - 3.2e-183 610.9 24.9 3.1e-182 607.6 24.9 2.3 1 1 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 EFA84916.1 - 1.9e-11 44.3 0.0 1.9e-11 44.3 0.0 3.3 3 1 0 3 3 2 1 AAA domain AAA_19 PF13245.6 EFA84916.1 - 2.2e-07 31.3 0.0 1e-06 29.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EFA84916.1 - 3.4e-05 23.9 0.0 3.4e-05 23.9 0.0 3.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFA84916.1 - 0.00035 20.3 0.0 0.00062 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EFA84916.1 - 0.003 17.4 0.0 0.01 15.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA84916.1 - 0.0065 16.8 0.0 0.028 14.7 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFA84916.1 - 0.0068 16.8 0.0 0.04 14.3 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EFA84916.1 - 0.0083 16.6 0.0 0.028 14.8 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.6 EFA84916.1 - 0.035 13.7 0.1 0.035 13.7 0.1 3.7 3 0 0 3 3 2 0 AAA domain PhoH PF02562.16 EFA84916.1 - 0.069 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein RuvB_N PF05496.12 EFA84916.1 - 0.077 12.7 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EFA84916.1 - 0.086 12.2 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EFA84916.1 - 4.4 7.9 0.0 4.4 7.9 0.0 4.0 4 2 1 5 5 5 0 AAA domain IP_trans PF02121.18 EFA84917.1 - 1.2e-31 110.1 3.3 7.3e-18 65.0 0.3 2.1 1 1 1 2 2 2 2 Phosphatidylinositol transfer protein DUF948 PF06103.11 EFA84918.1 - 0.0068 16.6 2.0 0.08 13.2 0.1 2.5 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) Mis14 PF08641.12 EFA84918.1 - 0.03 14.6 0.6 0.03 14.6 0.6 2.0 2 1 0 3 3 3 0 Kinetochore protein Mis14 like DUF2451 PF10474.9 EFA84918.1 - 0.053 13.3 0.4 0.088 12.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) MCR_C PF04609.12 EFA84918.1 - 0.1 11.6 2.2 0.14 11.2 1.6 1.6 1 1 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C Yippee-Mis18 PF03226.14 EFA84919.1 - 2.8e-12 46.8 0.2 3.4e-12 46.5 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 EFA84919.1 - 0.013 15.6 0.2 0.019 15.0 0.2 1.2 1 0 0 1 1 1 0 SelR domain DUF2039 PF10217.9 EFA84919.1 - 0.045 14.1 0.2 0.078 13.3 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) RIG-I_C-RD PF11648.8 EFA84919.1 - 0.048 13.9 0.1 0.066 13.4 0.1 1.2 1 0 0 1 1 1 0 C-terminal domain of RIG-I Acetyltransf_7 PF13508.7 EFA84920.1 - 2.9e-08 34.0 0.1 4.6e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA84920.1 - 4.9e-07 29.7 0.1 1.3e-06 28.4 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA84920.1 - 3.5e-06 27.2 0.0 5.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFA84920.1 - 0.00017 21.7 0.0 0.00034 20.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EFA84920.1 - 0.0011 18.6 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase FR47 PF08445.10 EFA84920.1 - 0.0022 17.9 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFA84920.1 - 0.0056 16.8 0.0 0.0097 16.0 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EFA84920.1 - 0.083 12.3 0.5 0.13 11.7 0.1 1.5 2 0 0 2 2 2 0 Putative acetyl-transferase Nucleoporin_FG PF13634.6 EFA84922.1 - 2.5e-15 57.1 122.7 7.1e-08 33.2 32.1 6.1 5 1 2 7 7 7 4 Nucleoporin FG repeat region SAP PF02037.27 EFA84923.1 - 0.00042 20.0 0.1 0.3 10.9 0.0 2.8 2 0 0 2 2 2 2 SAP domain LRR_4 PF12799.7 EFA84923.1 - 0.017 15.5 12.3 3.4 8.2 0.7 6.3 4 1 2 6 6 6 0 Leucine Rich repeats (2 copies) SAM_DrpA PF18255.1 EFA84923.1 - 6.3 7.1 8.6 8.6 6.7 0.1 4.2 5 0 0 5 5 5 0 DNA processing protein A sterile alpha motif domain DUF5365 PF17326.2 EFA84924.1 - 0.011 16.1 0.1 0.061 13.7 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5365) SAP PF02037.27 EFA84925.1 - 0.015 15.0 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 SAP domain Rho_N PF07498.12 EFA84925.1 - 0.29 11.1 5.0 0.13 12.2 1.9 2.1 2 1 0 2 2 2 0 Rho termination factor, N-terminal domain LRR_6 PF13516.6 EFA84926.1 - 0.053 13.6 4.0 0.085 13.0 0.4 2.9 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 EFA84926.1 - 0.2 12.1 12.6 0.76 10.3 2.5 4.3 2 1 3 5 5 5 0 Leucine Rich repeats (2 copies) DNA_pol_B PF00136.21 EFA84927.1 - 1.6e-136 455.7 0.5 2.7e-136 454.9 0.5 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFA84927.1 - 7.8e-83 278.4 0.2 1.7e-82 277.3 0.2 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain p450 PF00067.22 EFA84927.1 - 3e-32 112.0 0.5 6e-32 111.0 0.5 1.4 1 0 0 1 1 1 1 Cytochrome P450 FNIP PF05725.12 EFA84927.1 - 5.7e-31 106.4 28.0 3.8e-09 36.6 1.7 6.5 7 0 0 7 7 7 5 FNIP Repeat CAP PF00188.26 EFA84927.1 - 6.7e-15 56.0 0.0 2.4e-14 54.2 0.0 2.0 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TFIIA PF03153.13 EFA84927.1 - 1.6e-08 35.0 26.4 1.6e-08 35.0 26.4 2.9 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit B_lectin PF01453.24 EFA84927.1 - 9.8e-08 32.5 1.3 0.00034 21.1 0.5 2.5 1 1 1 2 2 2 2 D-mannose binding lectin DNA_pol_B_exo2 PF10108.9 EFA84927.1 - 0.06 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Cas_CXXC_CXXC PF09706.10 EFA84928.1 - 0.039 14.2 0.1 0.072 13.3 0.1 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) PCEMA1 PF07418.11 EFA84928.1 - 0.12 11.9 0.1 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Keratin_2_head PF16208.5 EFA84928.1 - 0.29 11.2 17.4 0.35 11.0 17.4 1.1 1 0 0 1 1 1 0 Keratin type II head Herpes_Helicase PF02689.14 EFA84929.1 - 0.01 13.8 0.4 0.01 13.8 0.4 1.0 1 0 0 1 1 1 0 Helicase DUF4587 PF15248.6 EFA84929.1 - 0.062 14.1 4.5 0.079 13.8 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4587) Med9 PF07544.13 EFA84930.1 - 0.014 15.5 3.3 0.65 10.1 3.9 2.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 GAF PF01590.26 EFA84931.1 - 0.00087 19.9 0.0 0.0016 19.1 0.0 1.5 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 EFA84931.1 - 0.017 15.4 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 GAF domain Nudix_hydro PF18290.1 EFA84933.1 - 1.4e-28 98.7 0.0 3.3e-28 97.5 0.0 1.7 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 EFA84933.1 - 1.6e-20 73.5 0.0 3.3e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain GST_N_2 PF13409.6 EFA84934.1 - 2.2e-22 79.1 0.0 4.7e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA84934.1 - 6.6e-14 51.7 0.1 1.5e-13 50.6 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFA84934.1 - 2.5e-06 27.6 0.1 4.9e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA84934.1 - 9.4e-06 26.0 0.1 0.00056 20.3 0.1 2.9 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA84934.1 - 0.0019 18.3 0.1 0.004 17.3 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA84934.1 - 0.0074 16.1 0.1 0.016 14.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EFA84934.1 - 0.033 14.8 0.0 0.089 13.4 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Endotoxin_N PF03945.14 EFA84935.1 - 1.6e-37 129.4 7.7 4.5e-37 127.9 7.7 1.8 1 0 0 1 1 1 1 delta endotoxin, N-terminal domain rve PF00665.26 EFA84935.1 - 6.3e-07 29.6 0.7 2.9e-05 24.2 0.7 2.6 1 1 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EFA84935.1 - 0.0013 18.8 6.5 0.015 15.4 0.1 3.1 3 0 0 3 3 3 2 Integrase zinc binding domain FNIP PF05725.12 EFA84936.1 - 7.2e-37 125.3 42.3 1.2e-12 47.8 0.2 9.1 8 2 1 9 9 9 6 FNIP Repeat F-box_5 PF18511.1 EFA84936.1 - 0.00057 19.4 0.0 0.0015 18.0 0.0 1.7 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA84936.1 - 0.009 15.9 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 F-box-like Actin PF00022.19 EFA84937.1 - 3.2e-117 391.6 0.1 8.5e-116 386.9 0.1 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFA84937.1 - 1.1e-05 24.4 0.0 2.6e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 MreB/Mbl protein MIF4G PF02854.19 EFA84938.1 - 1e-32 113.5 10.2 1e-32 113.5 10.2 2.0 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 EFA84938.1 - 9e-12 45.0 3.7 3.4e-10 39.9 0.1 3.1 3 0 0 3 3 3 2 MA3 domain Uso1_p115_head PF04869.14 EFA84939.1 - 2.9e-33 115.4 4.1 2.9e-33 115.4 4.1 2.9 2 1 1 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region TFIIA PF03153.13 EFA84939.1 - 2.9 7.8 27.8 6.1 6.7 27.8 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 EFA84939.1 - 3.5 7.1 22.0 0.051 13.1 11.3 2.8 3 0 0 3 3 3 0 Exonuclease VII, large subunit Imm42 PF15593.6 EFA84939.1 - 5.2 7.5 10.9 5.3 7.5 0.1 3.8 3 1 0 3 3 3 0 Immunity protein 42 Glyco_hydro_38N PF01074.22 EFA84943.1 - 3.3e-99 331.9 5.5 5e-99 331.3 5.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFA84943.1 - 4.6e-32 111.8 0.0 7.8e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFA84943.1 - 3e-19 69.0 0.1 6.7e-19 67.8 0.1 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EFA84943.1 - 3.5e-06 27.0 0.0 8.7e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 EFA84943.1 - 0.0003 20.1 0.1 0.00065 19.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Pkinase_Tyr PF07714.17 EFA84945.1 - 5.6e-33 114.3 0.4 4.1e-30 104.9 0.1 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFA84945.1 - 1.9e-24 86.4 0.1 1.9e-24 86.4 0.1 3.2 3 1 1 4 4 4 2 Protein kinase domain MORN PF02493.20 EFA84945.1 - 1.2e-05 24.9 6.9 0.0094 15.8 0.4 3.5 3 0 0 3 3 3 2 MORN repeat Kdo PF06293.14 EFA84945.1 - 0.035 13.5 0.1 0.085 12.2 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tyr-DNA_phospho PF06087.12 EFA84946.1 - 4.8e-40 137.8 3.1 9.3e-40 136.8 3.1 1.5 1 1 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EFA84946.1 - 6.1e-07 29.4 0.4 0.0055 16.6 0.1 2.7 2 0 0 2 2 2 2 PLD-like domain SopA PF13981.6 EFA84946.1 - 0.018 15.4 0.4 0.19 12.1 0.3 2.4 2 0 0 2 2 2 0 SopA-like central domain FNIP PF05725.12 EFA84948.1 - 3.5e-63 209.5 42.8 2.5e-13 49.9 2.6 12.1 7 3 7 14 14 14 10 FNIP Repeat F-box_5 PF18511.1 EFA84948.1 - 3e-07 29.9 1.5 0.00084 18.9 0.2 2.4 2 0 0 2 2 2 2 F-box SEP PF08059.13 EFA84948.1 - 0.0098 16.4 0.2 61 4.3 0.0 4.9 2 2 0 4 4 4 0 SEP domain DUF5599 PF18141.1 EFA84948.1 - 0.027 14.7 0.0 12 6.3 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5599) F-box-like PF12937.7 EFA84948.1 - 0.069 13.0 2.2 0.62 10.0 0.2 3.3 3 0 0 3 3 3 0 F-box-like Viral_Beta_CD PF04530.12 EFA84949.1 - 0.53 10.6 0.0 0.53 10.6 0.0 2.8 3 1 1 4 4 4 0 Viral Beta C/D like family Acetyltransf_13 PF13880.6 EFA84950.1 - 3.1e-23 81.5 0.1 7.2e-23 80.4 0.1 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EFA84950.1 - 1e-14 54.1 0.6 4.3e-14 52.1 0.6 2.2 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 EFA84950.1 - 0.0045 17.2 0.0 0.0081 16.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Rpr2 PF04032.16 EFA84950.1 - 0.056 13.7 6.2 0.32 11.3 6.0 2.5 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain FNIP PF05725.12 EFA84951.1 - 4.8e-23 81.1 26.3 2e-13 50.3 2.4 6.8 5 1 1 6 6 6 4 FNIP Repeat F-box_5 PF18511.1 EFA84951.1 - 5.6e-06 25.8 0.5 1.1e-05 24.9 0.5 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA84951.1 - 0.004 17.0 0.2 0.013 15.4 0.2 1.8 1 0 0 1 1 1 1 F-box-like DUF2804 PF10974.8 EFA84952.1 - 1.2e-103 347.1 0.6 1.5e-103 346.8 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2804) COesterase PF00135.28 EFA84953.1 - 8.1e-103 345.0 0.6 9.3e-103 344.8 0.6 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA84953.1 - 9.9e-07 28.8 0.1 3.8e-06 26.9 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 EFA84953.1 - 0.0056 16.2 0.1 0.04 13.4 0.0 2.1 1 1 1 2 2 2 1 Esterase PHB depolymerase Abhydrolase_6 PF12697.7 EFA84953.1 - 0.0081 16.8 0.7 0.016 15.8 0.7 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family PCI PF01399.27 EFA84954.1 - 3.4e-16 59.7 0.3 1.1e-15 58.0 0.1 2.1 2 0 0 2 2 2 1 PCI domain TPR_19 PF14559.6 EFA84954.1 - 0.0011 19.5 1.1 0.0083 16.6 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.9 EFA84954.1 - 0.003 17.3 0.8 0.0062 16.3 0.8 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 CSN4_RPN5_eIF3a PF18420.1 EFA84954.1 - 0.0044 17.2 1.5 0.0044 17.2 1.5 2.1 2 0 0 2 2 2 1 CSN4/RPN5/eIF3a helix turn helix domain TPR_7 PF13176.6 EFA84954.1 - 0.013 15.5 1.5 0.087 12.9 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA84954.1 - 0.014 15.7 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA84954.1 - 0.026 14.6 1.4 0.058 13.5 0.4 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA84954.1 - 0.031 14.1 0.6 0.14 12.0 0.3 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA84954.1 - 0.63 10.8 2.1 2.4 9.0 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Rho_N PF07498.12 EFA84956.1 - 0.11 12.4 0.4 0.11 12.4 0.4 2.1 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain RasGEF PF00617.19 EFA84957.1 - 6e-53 179.7 1.3 6e-53 179.7 1.3 2.0 2 0 0 2 2 2 1 RasGEF domain RCC1 PF00415.18 EFA84957.1 - 1.3e-40 137.7 11.3 3.6e-11 43.5 0.0 7.4 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA84957.1 - 2.6e-31 106.8 9.6 4.9e-10 38.9 0.5 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RasGEF_N PF00618.20 EFA84957.1 - 3.4e-18 65.8 3.7 3.5e-17 62.5 0.8 3.5 2 1 0 2 2 2 1 RasGEF N-terminal motif RhoGEF PF00621.20 EFA84957.1 - 4.5e-15 56.4 2.0 5.7e-13 49.5 0.5 2.8 2 0 0 2 2 2 2 RhoGEF domain Glyco_hydro_3 PF00933.21 EFA84959.1 - 4.5e-64 216.8 0.0 5.9e-64 216.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFA84959.1 - 7.8e-43 146.8 0.0 1.2e-42 146.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFA84959.1 - 9.2e-05 22.5 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Erp_C PF06780.11 EFA84959.1 - 0.18 11.8 0.0 0.41 10.7 0.0 1.5 1 0 0 1 1 1 0 Erp protein C-terminus DLIC PF05783.11 EFA84960.1 - 4.6e-97 325.8 1.0 6e-97 325.4 1.0 1.1 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Roc PF08477.13 EFA84960.1 - 0.0048 17.1 0.0 0.016 15.4 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FNIP PF05725.12 EFA84961.1 - 1e-34 118.4 27.8 4.9e-10 39.4 0.8 7.5 4 2 2 8 8 8 7 FNIP Repeat DUF1769 PF08588.10 EFA84961.1 - 0.0011 19.1 1.4 2.7 8.2 0.0 4.7 4 1 1 5 5 5 1 Protein of unknown function (DUF1769) ParBc_2 PF08857.11 EFA84962.1 - 6.4e-58 195.5 0.1 8e-58 195.1 0.1 1.1 1 0 0 1 1 1 1 Putative ParB-like nuclease FYVE PF01363.21 EFA84962.1 - 0.64 10.2 6.1 1.5 9.0 6.1 1.8 1 1 0 1 1 1 0 FYVE zinc finger EF-hand_5 PF13202.6 EFA84962.1 - 3.3 7.4 6.2 0.55 9.8 1.7 2.2 2 0 0 2 2 2 0 EF hand Ras PF00071.22 EFA84963.1 - 6.4e-42 142.9 0.1 1.4e-41 141.8 0.1 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA84963.1 - 6.7e-29 100.5 0.1 1.8e-28 99.2 0.1 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA84963.1 - 1.4e-18 66.9 0.1 4e-18 65.5 0.1 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Pur_ac_phosph_N PF16656.5 EFA84963.1 - 3.6e-09 37.1 0.0 1.1e-08 35.6 0.0 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain MMR_HSR1 PF01926.23 EFA84963.1 - 3e-06 27.3 0.0 1.1e-05 25.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFA84963.1 - 2.9e-05 23.6 0.1 6.4e-05 22.4 0.1 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFA84963.1 - 0.00071 19.2 0.1 0.0023 17.5 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFA84963.1 - 0.0024 17.6 0.0 0.018 14.8 0.0 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Metallophos PF00149.28 EFA84963.1 - 0.03 14.8 0.1 0.062 13.8 0.1 1.7 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase TniB PF05621.11 EFA84963.1 - 0.053 12.9 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 EFA84963.1 - 0.12 11.8 0.1 0.33 10.4 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ORC4_C PF14629.6 EFA84964.1 - 1.1e-08 34.7 1.0 1.6e-08 34.2 0.8 1.4 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus MRVI1 PF05781.12 EFA84964.1 - 0.084 11.6 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 MRVI1 protein Sin3a_C PF16879.5 EFA84965.1 - 2.3e-63 214.6 7.5 2.3e-63 214.6 7.5 6.1 5 2 2 7 7 7 2 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 EFA84965.1 - 5.7e-38 128.9 0.2 3.9e-37 126.3 0.0 2.7 2 0 0 2 2 2 1 Sin3 family co-repressor PAH PF02671.21 EFA84965.1 - 6.8e-36 122.2 15.2 6.5e-14 51.8 0.0 5.3 4 0 0 4 4 4 3 Paired amphipathic helix repeat COX5A PF02284.16 EFA84965.1 - 0.11 12.5 9.5 3.9 7.5 2.9 3.2 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Va UPF0565 PF10561.9 EFA84965.1 - 9.4 5.3 29.7 0.24 10.6 4.4 3.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0565 GST_N_3 PF13417.6 EFA84966.1 - 3.3e-12 46.6 0.0 6.2e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA84966.1 - 9.5e-12 45.1 0.0 1.9e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFA84966.1 - 1.3e-11 44.6 0.1 2.5e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA84966.1 - 3e-10 40.2 0.0 6.6e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA84966.1 - 8.1e-08 32.4 0.0 1.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA84966.1 - 2e-06 27.7 0.0 4.2e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFA84966.1 - 0.0021 18.8 0.0 0.026 15.3 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain Glutaredoxin2_C PF04399.13 EFA84966.1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Glutaredoxin PF00462.24 EFA84966.1 - 0.045 14.0 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Glutaredoxin DUF2733 PF10813.8 EFA84966.1 - 0.16 11.7 0.1 0.31 10.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2733) DUF896 PF05979.12 EFA84967.1 - 0.059 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) Ank_2 PF12796.7 EFA84968.1 - 8.1e-05 23.1 0.3 0.017 15.7 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA84968.1 - 0.0071 16.9 0.2 30 5.3 0.0 4.1 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84968.1 - 0.063 13.9 0.5 1.4e+02 3.6 0.0 5.5 6 0 0 6 6 6 0 Ankyrin repeat CSG2 PF16965.5 EFA84968.1 - 0.98 8.3 3.6 1.8 7.4 3.6 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator FAM176 PF14851.6 EFA84968.1 - 9.5 5.9 9.8 12 5.6 0.7 2.3 2 0 0 2 2 2 0 FAM176 family AhpC-TSA PF00578.21 EFA84970.1 - 7.3e-43 145.4 0.0 1e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFA84970.1 - 2.6e-26 92.1 0.0 3.5e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EFA84970.1 - 0.00011 22.2 0.0 0.00031 20.8 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme SCO1-SenC PF02630.14 EFA84970.1 - 0.0015 18.4 0.1 0.0045 16.9 0.1 1.8 1 1 0 1 1 1 1 SCO1/SenC GSHPx PF00255.19 EFA84970.1 - 0.031 13.8 0.0 0.07 12.7 0.0 1.6 1 1 0 1 1 1 0 Glutathione peroxidase DUF899 PF05988.12 EFA84970.1 - 0.033 13.7 0.1 0.079 12.5 0.0 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF899) XRCC1_N PF01834.16 EFA84971.1 - 2.2e-44 151.1 0.6 2.2e-44 151.1 0.6 2.2 2 0 0 2 2 2 1 XRCC1 N terminal domain BRCT_2 PF16589.5 EFA84971.1 - 4.1e-14 52.8 4.2 8.4e-09 35.7 0.4 3.2 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA84971.1 - 9.4e-11 42.0 0.0 0.0012 19.2 0.0 3.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFA84971.1 - 2.7e-07 30.8 0.0 0.0026 18.0 0.0 2.9 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 EFA84971.1 - 0.00099 19.0 0.0 0.0022 17.9 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain 23S_rRNA_IVP PF05635.11 EFA84971.1 - 0.11 12.8 0.6 0.25 11.7 0.6 1.6 1 0 0 1 1 1 0 23S rRNA-intervening sequence protein WD40 PF00400.32 EFA84972.1 - 6e-35 118.7 24.8 0.00022 21.9 0.0 10.8 11 0 0 11 11 11 8 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EFA84972.1 - 2.8e-06 26.5 8.8 0.00048 19.2 0.0 4.5 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EFA84972.1 - 0.0004 20.6 5.0 5.5 7.4 0.1 6.2 3 2 4 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain ABC2_membrane PF01061.24 EFA84973.1 - 2.1e-84 282.1 53.1 9.6e-45 152.6 23.1 3.0 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 EFA84973.1 - 8.2e-49 165.6 0.1 5.2e-23 82.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA84973.1 - 8.3e-10 38.5 0.1 0.00018 21.1 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFA84973.1 - 9.1e-08 32.2 0.1 0.003 17.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFA84973.1 - 3e-06 27.5 0.0 0.093 13.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA84973.1 - 3.3e-06 27.6 0.0 0.12 12.8 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EFA84973.1 - 3.5e-06 27.2 2.5 0.008 16.3 0.0 2.6 3 0 0 3 3 2 2 AAA domain PDR_CDR PF06422.12 EFA84973.1 - 4.5e-06 26.5 2.4 0.021 14.7 0.3 2.9 2 0 0 2 2 2 2 CDR ABC transporter AAA_21 PF13304.6 EFA84973.1 - 7.2e-06 26.0 1.1 0.62 9.8 0.1 3.8 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EFA84973.1 - 1.1e-05 25.8 0.1 0.0053 17.2 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFA84973.1 - 1.8e-05 25.3 0.0 0.23 12.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFA84973.1 - 2.7e-05 23.8 0.3 0.0043 16.8 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EFA84973.1 - 3.4e-05 23.5 0.0 0.046 13.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EFA84973.1 - 4.4e-05 23.8 0.0 0.34 11.3 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 EFA84973.1 - 4.5e-05 23.8 0.2 0.3 11.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EFA84973.1 - 5.8e-05 23.1 0.1 0.58 10.1 0.0 2.9 3 0 0 3 3 3 2 Rad17 P-loop domain NACHT PF05729.12 EFA84973.1 - 0.00045 20.2 0.1 0.55 10.1 0.0 2.4 2 0 0 2 2 2 2 NACHT domain Zeta_toxin PF06414.12 EFA84973.1 - 0.00048 19.5 0.0 0.076 12.3 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_5 PF07728.14 EFA84973.1 - 0.0012 18.9 0.2 0.32 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EFA84973.1 - 0.0017 18.9 0.1 0.88 10.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA84973.1 - 0.0017 18.1 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EFA84973.1 - 0.0024 17.9 0.1 1.9 8.6 0.0 3.0 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_17 PF13207.6 EFA84973.1 - 0.0029 18.0 0.0 3.3 8.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EFA84973.1 - 0.0032 16.7 0.4 0.021 14.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EFA84973.1 - 0.0043 16.8 0.1 3.8 7.2 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein TsaE PF02367.17 EFA84973.1 - 0.0061 16.6 0.5 0.64 10.0 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFA84973.1 - 0.0079 15.7 0.0 0.44 10.0 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 EFA84973.1 - 0.017 15.4 0.1 11 6.2 0.0 2.8 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EFA84973.1 - 0.034 13.7 0.3 4.4 6.9 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 EFA84973.1 - 0.078 13.3 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EFA84973.1 - 0.093 12.5 0.4 5.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SbcCD_C PF13558.6 EFA84973.1 - 0.13 12.6 0.0 1 9.6 0.0 2.6 3 0 0 3 3 1 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 EFA84973.1 - 0.14 11.8 0.3 7.8 6.1 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 EFA84973.1 - 0.16 11.7 0.1 10 5.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFA84973.1 - 0.19 10.9 0.1 4 6.5 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Mg_chelatase PF01078.21 EFA84973.1 - 0.21 11.0 1.1 2.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PDR_assoc PF08370.11 EFA84973.1 - 0.27 11.0 5.4 1.6 8.5 0.4 3.1 2 0 0 2 2 2 0 Plant PDR ABC transporter associated Band_7 PF01145.25 EFA84974.1 - 7.2e-06 26.1 2.3 7.2e-06 26.1 2.3 2.4 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EFA84974.1 - 0.1 12.3 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family UCH PF00443.29 EFA84975.1 - 3.5e-45 154.5 11.6 3.5e-45 154.5 11.6 2.6 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA84975.1 - 1.8e-26 93.5 15.1 1.8e-26 93.5 15.1 2.9 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase IFT20 PF14931.6 EFA84976.1 - 0.00019 21.6 4.4 0.00019 21.6 4.4 4.6 3 2 1 4 4 3 1 Intraflagellar transport complex B, subunit 20 ATG16 PF08614.11 EFA84976.1 - 0.0025 18.1 27.4 0.0025 18.1 27.4 5.0 2 1 3 5 5 4 2 Autophagy protein 16 (ATG16) ubiquitin PF00240.23 EFA84976.1 - 0.0035 17.1 0.2 0.19 11.5 0.0 3.3 2 0 0 2 2 2 1 Ubiquitin family TUG-UBL1 PF11470.8 EFA84976.1 - 0.019 15.2 0.2 1.4 9.2 0.0 2.8 2 0 0 2 2 2 0 TUG ubiquitin-like domain RBD PF02196.15 EFA84976.1 - 0.03 14.4 0.1 0.62 10.2 0.0 2.5 2 0 0 2 2 2 0 Raf-like Ras-binding domain gpW PF02831.15 EFA84976.1 - 0.035 14.0 0.3 0.21 11.5 0.1 2.5 2 0 0 2 2 2 0 gpW CENP-F_leu_zip PF10473.9 EFA84976.1 - 0.1 12.7 67.0 0.43 10.6 15.0 5.6 2 1 4 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG12 PF04110.13 EFA84976.1 - 0.12 12.7 1.1 8.7 6.8 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-like autophagy protein Apg12 ALS_ss_C PF10369.9 EFA84976.1 - 1.1 9.5 6.6 5 7.4 0.1 3.5 3 0 0 3 3 3 0 Small subunit of acetolactate synthase DUF3138 PF11336.8 EFA84976.1 - 3.1 6.3 8.2 0.5 8.9 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) DUF16 PF01519.16 EFA84976.1 - 8.7 6.9 35.8 1.3 9.5 0.8 5.2 4 0 0 4 4 4 0 Protein of unknown function DUF16 AAA_13 PF13166.6 EFA84976.1 - 8.9 4.8 55.5 0.21 10.2 3.6 4.1 1 1 2 4 4 4 0 AAA domain Pkinase_Tyr PF07714.17 EFA84977.1 - 6.8e-53 179.6 0.1 1.1e-52 178.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA84977.1 - 1.4e-48 165.6 0.0 2.4e-48 164.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RGS PF00615.19 EFA84977.1 - 1.1e-14 54.7 0.4 4.5e-14 52.7 0.4 2.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain APH PF01636.23 EFA84977.1 - 0.038 13.9 0.0 1.3 8.9 0.1 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family Ank_4 PF13637.6 EFA84978.1 - 5.8e-22 77.8 2.2 0.00012 22.5 0.0 8.5 6 3 3 9 9 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84978.1 - 1.5e-20 73.6 1.0 1.4e-05 25.6 0.8 6.2 2 1 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA84978.1 - 6.7e-15 55.0 5.5 1.3 9.4 0.0 10.6 7 2 6 13 13 13 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA84978.1 - 1.4e-13 49.7 1.6 4.6 8.1 0.0 11.3 14 0 0 14 14 14 3 Ankyrin repeat DUF3447 PF11929.8 EFA84978.1 - 0.034 14.1 11.2 2.9 7.9 0.2 5.2 3 1 2 6 6 6 0 Domain of unknown function (DUF3447) Ank PF00023.30 EFA84978.1 - 0.048 14.1 0.0 1.2e+02 3.4 0.0 4.9 4 1 0 4 4 4 0 Ankyrin repeat VPS13 PF16908.5 EFA84979.1 - 2e-65 220.9 30.3 2.5e-65 220.6 8.7 4.6 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 EFA84979.1 - 5.5e-59 199.4 16.1 4e-56 190.1 5.8 6.2 6 1 0 6 6 6 3 Repeating coiled region of VPS13 VPS13_C PF16909.5 EFA84979.1 - 1.6e-52 177.8 18.1 9.7e-52 175.3 0.1 4.7 4 0 0 4 4 4 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 EFA84979.1 - 6.7e-35 120.8 5.8 1.6e-28 99.9 0.1 5.0 4 1 1 5 5 5 2 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 EFA84979.1 - 4.2e-26 91.3 1.2 4.2e-26 91.3 1.2 4.3 5 0 0 5 5 5 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EFA84979.1 - 8.3e-09 35.7 0.0 5.6e-08 33.0 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Coiled PF05710.12 EFA84980.1 - 0.016 16.0 4.8 0.019 15.8 4.8 1.2 1 0 0 1 1 1 0 Coiled coil FNIP PF05725.12 EFA84981.1 - 4.4e-27 94.0 26.6 9.4e-13 48.1 0.3 7.2 7 1 1 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA84981.1 - 1.3e-05 24.7 0.2 2.3e-05 23.8 0.2 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA84981.1 - 0.066 13.1 0.6 0.21 11.5 0.2 2.1 2 0 0 2 2 2 0 F-box-like Tim29 PF10171.9 EFA84982.1 - 0.0032 17.0 0.0 1.2 8.6 0.0 2.0 1 1 1 2 2 2 2 Translocase of the Inner Mitochondrial membrane 29 2OG-FeII_Oxy_3 PF13640.6 EFA84983.1 - 1.9e-08 35.0 0.0 3.7e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EFA84983.1 - 0.13 12.9 0.0 0.28 11.9 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF3439 PF11921.8 EFA84983.1 - 3.5 7.6 10.9 7.2 6.6 10.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Kinesin PF00225.23 EFA84984.1 - 2.4e-106 355.4 6.8 2.4e-106 355.4 6.8 3.3 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFA84984.1 - 9.5e-54 181.4 0.3 9.5e-54 181.4 0.3 2.8 2 1 0 2 2 2 1 Microtubule binding CBM9_2 PF16011.5 EFA84985.1 - 0.024 14.3 0.2 0.026 14.2 0.2 1.2 1 0 0 1 1 1 0 Carbohydrate-binding family 9 DUF5578 PF17741.1 EFA84985.1 - 0.073 12.5 0.2 0.094 12.1 0.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5578) CutA1 PF03091.15 EFA84986.1 - 0.13 12.2 0.0 0.37 10.7 0.0 1.7 2 0 0 2 2 2 0 CutA1 divalent ion tolerance protein Cnd1 PF12717.7 EFA84988.1 - 2.9e-46 157.5 8.3 1.1e-43 149.1 2.1 5.0 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Nipped-B_C PF12830.7 EFA84988.1 - 0.0012 18.8 1.5 0.051 13.5 1.5 3.0 1 1 0 1 1 1 1 Sister chromatid cohesion C-terminus HEAT_2 PF13646.6 EFA84988.1 - 0.0042 17.5 0.2 0.23 11.9 0.0 3.6 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 EFA84988.1 - 0.0074 16.5 0.1 33 5.1 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat Adeno_E1B_55K_N PF04623.12 EFA84988.1 - 0.19 12.5 1.4 0.94 10.2 1.4 2.2 1 0 0 1 1 1 0 Adenovirus E1B protein N-terminus Abhydrolase_1 PF00561.20 EFA84989.1 - 2.7e-05 24.0 0.2 0.005 16.5 0.0 3.0 3 0 0 3 3 3 2 alpha/beta hydrolase fold DUF2920 PF11144.8 EFA84989.1 - 0.026 13.7 0.0 0.65 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) TPR_1 PF00515.28 EFA84990.1 - 1.4e-09 37.3 9.3 1.4e-05 24.6 0.4 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA84990.1 - 1.9e-06 27.6 10.4 1.5e-05 24.8 0.4 3.2 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA84990.1 - 6.3e-06 25.8 11.5 0.00027 20.6 3.3 2.5 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 EFA84990.1 - 1.1e-05 26.0 3.0 2.1e-05 25.1 3.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA84990.1 - 1.9e-05 24.5 5.9 0.0026 17.8 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA84990.1 - 5.4e-05 23.6 4.3 0.00015 22.2 4.3 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA84990.1 - 6.1e-05 23.2 3.8 0.00013 22.2 3.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA84990.1 - 7.1e-05 23.3 1.7 0.026 15.3 0.7 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA84990.1 - 0.00015 21.6 3.3 0.0041 17.1 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA84990.1 - 0.011 16.0 1.2 0.011 16.0 1.2 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF5113 PF17140.4 EFA84990.1 - 0.018 14.9 4.2 0.22 11.3 1.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) TPR_10 PF13374.6 EFA84990.1 - 0.041 13.7 2.6 1.6 8.7 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFA84990.1 - 0.049 13.8 0.2 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Nup160 PF11715.8 EFA84991.1 - 1.1e-25 90.3 7.0 3.8e-17 62.1 2.6 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 CcmE PF03100.15 EFA84991.1 - 5.7e-08 32.8 0.0 1.5e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 CcmE ANAPC3 PF12895.7 EFA84991.1 - 0.28 11.4 1.8 0.7 10.2 0.7 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Rotavirus_VP1 PF12289.8 EFA84992.1 - 0.0055 15.8 0.5 0.46 9.5 0.5 2.1 1 1 0 1 1 1 1 Rotavirus VP1 C-terminal domain FANCI_S1-cap PF14674.6 EFA84994.1 - 0.2 11.8 0.8 21 5.3 0.1 2.6 2 0 0 2 2 2 0 FANCI solenoid 1 cap SAP PF02037.27 EFA84994.1 - 0.52 10.1 4.5 3.5 7.5 0.1 2.9 3 0 0 3 3 3 0 SAP domain DUF2251 PF10008.9 EFA84994.1 - 1.3 9.2 7.1 31 4.7 0.1 4.4 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2251) Ank_4 PF13637.6 EFA84997.1 - 4e-31 107.0 11.3 0.0003 21.3 0.0 11.0 6 3 3 10 10 10 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA84997.1 - 1.4e-27 96.0 7.0 2.5e-06 28.0 0.0 7.2 3 3 4 8 8 8 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA84997.1 - 1.4e-14 52.7 12.6 15 6.5 0.0 14.7 17 1 1 18 18 18 3 Ankyrin repeat Ank_5 PF13857.6 EFA84997.1 - 1.7e-14 53.6 5.9 6.3 7.3 0.0 11.1 5 2 8 13 13 13 5 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA84997.1 - 0.013 15.5 16.8 1.1 9.3 0.1 7.4 4 2 4 9 9 9 0 Domain of unknown function (DUF3447) Stap_Strp_toxin PF01123.20 EFA84999.1 - 0.4 11.6 3.7 0.78 10.6 1.8 2.3 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain zf-LYAR PF08790.11 EFA85000.1 - 3.6e-09 36.4 5.0 3.6e-09 36.4 5.0 2.8 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 EFA85000.1 - 0.0084 15.7 3.1 0.74 9.5 0.2 2.4 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-ACC PF17848.1 EFA85000.1 - 0.25 11.4 1.7 1.9 8.6 0.0 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Zn-ribbon_8 PF09723.10 EFA85000.1 - 0.26 11.4 5.2 6.4 7.0 1.0 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 EFA85000.1 - 0.26 10.7 1.5 2.3 7.7 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 EFA85000.1 - 0.68 10.0 4.3 1.5 8.9 4.3 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2 PF00096.26 EFA85000.1 - 2.7 8.6 5.8 1.6 9.3 1.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFA85000.1 - 3.6 8.7 7.7 0.42 11.6 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger DM PF00751.18 EFA85000.1 - 5.2 7.1 7.2 9.4 6.2 7.2 1.4 1 0 0 1 1 1 0 DM DNA binding domain RNA_pol_Rpb2_6 PF00562.28 EFA85001.1 - 1.5e-108 363.3 0.8 3.6e-108 362.1 0.8 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFA85001.1 - 8.3e-33 113.6 0.0 1.1e-32 113.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EFA85001.1 - 4.3e-27 94.1 0.0 8.2e-27 93.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EFA85001.1 - 6.7e-23 80.9 0.1 2.3e-22 79.2 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 EFA85001.1 - 6.2e-20 71.0 0.0 2.2e-19 69.2 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EFA85001.1 - 2.7e-17 63.0 0.1 4.9e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Thioredoxin_15 PF18403.1 EFA85001.1 - 0.058 13.3 0.0 0.25 11.2 0.0 1.9 1 1 1 2 2 2 0 Thioredoxin-like domain Pkinase PF00069.25 EFA85002.1 - 2.4e-71 240.2 4.7 4.7e-71 239.3 0.0 3.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85002.1 - 1.7e-55 188.1 1.7 2.5e-55 187.6 0.0 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA85002.1 - 1.3e-06 28.0 0.0 3.6e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFA85002.1 - 0.00031 19.7 5.8 0.00031 19.7 5.8 5.2 4 2 0 4 4 4 1 Fungal protein kinase PBD PF00786.28 EFA85002.1 - 0.0063 16.8 0.2 0.0063 16.8 0.2 3.2 2 0 0 2 2 2 1 P21-Rho-binding domain AAA_25 PF13481.6 EFA85002.1 - 0.14 11.8 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Imm7 PF15585.6 EFA85002.1 - 0.53 10.6 2.8 2.3 8.5 0.0 3.2 4 0 0 4 4 4 0 Immunity protein 7 LIM PF00412.22 EFA85003.1 - 1.8e-29 101.7 27.4 2.4e-12 46.9 4.9 3.5 3 0 0 3 3 3 3 LIM domain Abhydrolase_1 PF00561.20 EFA85003.1 - 1.5e-15 57.6 0.6 1.9e-10 40.8 0.3 3.1 2 1 1 3 3 3 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA85003.1 - 6.8e-13 48.4 0.0 2.5e-12 46.6 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFA85003.1 - 1.3e-10 42.3 0.0 1.9e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EFA85003.1 - 0.00056 19.7 0.0 0.0076 16.0 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ndr PF03096.14 EFA85003.1 - 0.00072 18.3 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 Ndr family PGAP1 PF07819.13 EFA85003.1 - 0.0033 17.2 0.0 0.0057 16.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 EFA85003.1 - 0.0047 16.6 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Putative esterase FSH1 PF03959.13 EFA85003.1 - 0.0061 16.2 0.1 0.16 11.7 0.0 2.7 1 1 0 2 2 2 1 Serine hydrolase (FSH1) UPF0227 PF05728.12 EFA85003.1 - 0.017 15.0 0.0 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Abhydrolase_2 PF02230.16 EFA85003.1 - 0.021 14.7 0.9 0.41 10.4 0.0 2.7 4 0 0 4 4 4 0 Phospholipase/Carboxylesterase DUF2048 PF09752.9 EFA85003.1 - 0.022 13.9 0.1 0.32 10.1 0.1 2.0 1 1 0 1 1 1 0 Abhydrolase domain containing 18 DLH PF01738.18 EFA85003.1 - 0.04 13.5 0.1 1.9 8.0 0.1 2.8 2 1 0 2 2 2 0 Dienelactone hydrolase family Lipase_3 PF01764.25 EFA85003.1 - 0.075 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF915 PF06028.11 EFA85003.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DUF3530 PF12048.8 EFA85003.1 - 0.19 11.1 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) zinc-ribbons_6 PF07191.12 EFA85003.1 - 0.22 11.5 19.6 3.8 7.6 3.0 3.6 2 1 1 3 3 3 0 zinc-ribbons MBOAT PF03062.19 EFA85004.1 - 4.3e-22 78.9 32.3 9.3e-22 77.8 32.3 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EFA85004.1 - 0.00024 21.3 7.6 0.00066 19.9 7.6 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family GREB1 PF15782.5 EFA85004.1 - 0.00031 18.1 5.8 0.00041 17.6 5.8 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 EFA85004.1 - 1.3 8.6 15.7 2.8 7.5 15.7 1.5 1 0 0 1 1 1 0 Spt20 family Hydin_ADK PF17213.3 EFA85004.1 - 5.4 7.2 9.9 8.2 6.7 9.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain TFIIA PF03153.13 EFA85004.1 - 9.3 6.1 18.0 13 5.7 18.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ACOX PF01756.19 EFA85005.1 - 5.8e-22 78.1 0.2 1.3e-21 77.0 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFA85005.1 - 8.3e-15 54.8 0.0 2.1e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EFA85005.1 - 0.0046 17.5 0.1 0.013 16.0 0.1 1.8 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EFA85005.1 - 0.022 15.0 0.0 0.091 13.0 0.0 2.0 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain GSH-S_ATP PF02955.16 EFA85005.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain SapB_1 PF05184.15 EFA85006.1 - 7.5e-16 57.8 14.9 4.1e-10 39.5 2.4 3.1 3 0 0 3 3 3 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA85006.1 - 5.9e-11 42.3 0.7 1.9e-10 40.7 0.7 1.9 1 0 0 1 1 1 1 Saposin-like type B, region 2 DUF5097 PF17020.5 EFA85006.1 - 0.032 14.6 0.9 0.28 11.5 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5097) F-box-like PF12937.7 EFA85007.1 - 0.11 12.4 3.3 6.1 6.8 3.3 2.7 1 1 0 1 1 1 0 F-box-like TFIID_20kDa PF03847.13 EFA85008.1 - 1.7e-30 105.3 0.9 2.9e-30 104.5 0.9 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A SR-25 PF10500.9 EFA85008.1 - 0.00012 21.8 15.9 0.00012 21.8 15.9 3.3 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF2514 PF10721.9 EFA85008.1 - 0.0068 16.4 5.9 0.0068 16.4 5.9 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2514) TAF4 PF05236.14 EFA85008.1 - 0.013 15.2 4.2 0.013 15.2 4.2 4.7 2 1 3 5 5 5 0 Transcription initiation factor TFIID component TAF4 family Eapp_C PF10238.9 EFA85008.1 - 2.4 8.2 15.3 0.79 9.8 4.4 2.9 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF2052 PF09747.9 EFA85008.1 - 2.6 8.1 19.5 0.75 9.9 9.7 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DDRGK PF09756.9 EFA85008.1 - 6.1 6.4 29.8 0.16 11.5 18.1 2.2 2 0 0 2 2 2 0 DDRGK domain Pox_P21 PF05313.12 EFA85009.1 - 0.11 12.0 3.7 0.24 11.0 0.9 2.6 3 0 0 3 3 3 0 Poxvirus P21 membrane protein SGT1 PF07093.11 EFA85011.1 - 2.8e-115 386.0 17.2 5e-114 381.9 17.2 2.0 1 1 0 1 1 1 1 SGT1 protein Ank_2 PF12796.7 EFA85012.1 - 3.7e-14 53.1 4.2 0.011 16.3 0.0 5.6 1 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85012.1 - 5.4e-12 46.0 12.3 0.14 12.7 0.0 8.0 5 3 1 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85012.1 - 2.6e-11 43.5 5.7 0.29 11.5 0.0 8.0 4 3 4 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85012.1 - 1.3e-09 37.5 8.6 24 5.9 0.0 9.7 10 0 0 10 10 10 3 Ankyrin repeat RhoGAP PF00620.27 EFA85013.1 - 2.4e-30 105.4 0.1 5.1e-30 104.3 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain Mito_fiss_reg PF05308.11 EFA85013.1 - 0.36 10.9 2.2 21 5.1 0.9 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator 7tm_3 PF00003.22 EFA85014.1 - 1.8e-08 34.4 11.5 1.8e-08 34.4 11.5 2.1 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4834 PF16118.5 EFA85014.1 - 0.0047 17.9 0.6 0.0047 17.9 0.6 4.3 2 1 2 4 4 4 1 Domain of unknown function (DUF4834) Tmemb_18A PF09771.9 EFA85014.1 - 0.052 13.9 5.1 1.3 9.4 1.1 2.6 2 0 0 2 2 2 0 Transmembrane protein 188 DUF2981 PF11200.8 EFA85014.1 - 0.99 9.1 6.7 2 8.1 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Ank_2 PF12796.7 EFA85015.1 - 1.6e-39 134.3 24.9 2.5e-08 34.4 0.1 7.8 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85015.1 - 4.5e-29 100.4 10.9 0.0014 19.2 0.0 10.4 5 3 6 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85015.1 - 3.3e-21 73.1 6.2 1.1 10.0 0.0 15.4 18 0 0 18 18 18 2 Ankyrin repeat Ank_5 PF13857.6 EFA85015.1 - 1.3e-20 73.1 7.6 0.035 14.4 0.0 12.6 7 3 5 13 13 13 5 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA85015.1 - 4.6e-07 29.7 15.2 0.22 11.5 0.4 7.2 4 3 2 7 7 7 4 Domain of unknown function (DUF3447) DUF249 PF03158.13 EFA85015.1 - 0.031 14.0 9.4 5.9 6.5 0.1 5.8 4 3 2 6 6 6 0 Multigene family 530 protein Ank PF00023.30 EFA85015.1 - 0.52 10.9 2.2 5.8e+02 1.2 0.0 6.6 7 2 0 7 7 7 0 Ankyrin repeat Dimer_Tnp_hAT PF05699.14 EFA85015.1 - 0.74 9.7 5.1 1.8 8.4 0.1 4.3 4 2 1 5 5 5 0 hAT family C-terminal dimerisation region Metallophos PF00149.28 EFA85016.1 - 4.2e-11 43.7 0.4 5e-11 43.5 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA85016.1 - 0.00053 20.2 0.0 0.00087 19.5 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Kinesin PF00225.23 EFA85017.1 - 1.3e-110 369.5 0.0 1.3e-110 369.5 0.0 3.3 3 0 0 3 3 3 1 Kinesin motor domain Kinesin_assoc PF16183.5 EFA85017.1 - 8.3e-27 94.5 3.9 5.2e-21 75.6 1.4 5.9 4 2 2 6 6 5 2 Kinesin-associated Microtub_bd PF16796.5 EFA85017.1 - 4.5e-20 72.1 2.8 7.9e-20 71.3 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding PH PF00169.29 EFA85017.1 - 6.4e-11 42.7 2.0 3e-10 40.5 1.2 2.6 2 0 0 2 2 2 1 PH domain FHA PF00498.26 EFA85017.1 - 1.4e-06 28.5 0.8 5.8e-06 26.6 0.2 2.4 2 0 0 2 2 2 1 FHA domain DUF3694 PF12473.8 EFA85017.1 - 5.5e-06 27.1 1.4 0.00059 20.5 0.8 4.1 2 1 0 2 2 2 1 Kinesin protein Yop-YscD_cpl PF16697.5 EFA85017.1 - 7.3e-05 23.0 0.1 0.00034 20.9 0.0 2.2 2 0 0 2 2 1 1 Inner membrane component of T3SS, cytoplasmic domain PH_8 PF15409.6 EFA85017.1 - 0.0023 18.2 0.5 0.0075 16.5 0.5 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain KIF1B PF12423.8 EFA85017.1 - 0.017 15.6 1.7 0.044 14.2 0.1 2.8 2 0 0 2 2 1 0 Kinesin protein 1B RepA_N PF06970.11 EFA85017.1 - 0.39 10.7 4.6 6.7 6.7 0.2 3.4 3 0 0 3 3 3 0 Replication initiator protein A (RepA) N-terminus JUPITER PF17054.5 EFA85017.1 - 1.5 8.2 13.8 0.027 14.0 6.1 2.0 2 0 0 2 2 2 0 Microtubule-Associated protein Jupiter Bro-N PF02498.17 EFA85017.1 - 2.1 9.1 5.3 1.1 9.9 1.0 3.0 2 0 0 2 2 1 0 BRO family, N-terminal domain RhoGEF PF00621.20 EFA85018.1 - 3e-44 151.4 8.4 3e-44 151.4 8.4 2.9 3 2 1 4 4 4 1 RhoGEF domain PH PF00169.29 EFA85018.1 - 1.5e-13 51.2 2.6 1.7e-13 51.0 0.3 2.4 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA85018.1 - 9.8e-05 22.6 0.2 9.8e-05 22.6 0.2 2.6 3 0 0 3 3 3 1 Pleckstrin homology domain PH_11 PF15413.6 EFA85018.1 - 0.0023 18.3 8.4 0.0028 18.1 2.1 3.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 EFA85018.1 - 0.047 14.0 0.2 0.22 11.8 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain TIG PF01833.24 EFA85019.1 - 1.4 9.1 11.2 0.52 10.4 6.6 2.7 2 2 0 2 2 2 0 IPT/TIG domain adh_short PF00106.25 EFA85020.1 - 1.3e-37 129.2 0.0 1.8e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA85020.1 - 2.2e-20 73.2 0.0 3.6e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA85020.1 - 1.9e-14 54.0 0.0 3.1e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFA85020.1 - 0.00015 21.0 0.1 0.00021 20.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Peptidase_M76 PF09768.9 EFA85021.1 - 1.9e-46 158.0 2.8 2.4e-46 157.6 2.8 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EFA85021.1 - 0.0031 17.4 0.2 0.0084 16.0 0.2 1.8 1 0 0 1 1 1 1 SprT-like family IL3 PF02059.15 EFA85021.1 - 0.048 13.7 1.2 2.3 8.3 2.0 2.2 2 0 0 2 2 2 0 Interleukin-3 Ceramidase PF05875.12 EFA85023.1 - 2.6e-36 125.4 6.9 3.2e-36 125.1 6.9 1.1 1 0 0 1 1 1 1 Ceramidase YidD PF01809.18 EFA85023.1 - 0.062 13.2 0.2 0.15 12.0 0.2 1.6 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor DUF727 PF05303.12 EFA85024.1 - 4.2e-28 97.5 0.7 4.7e-28 97.3 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF727) EAP30 PF04157.16 EFA85025.1 - 9.7e-72 241.1 0.4 1.1e-71 240.9 0.4 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Activator-TraM PF11657.8 EFA85025.1 - 0.1 12.5 1.1 0.19 11.5 1.1 1.4 1 0 0 1 1 1 0 Transcriptional activator TraM RhoGAP PF00620.27 EFA85026.1 - 4.9e-34 117.4 0.7 8.5e-34 116.6 0.1 1.6 2 0 0 2 2 2 1 RhoGAP domain Reg_prop PF07494.11 EFA85026.1 - 2.9e-05 23.8 3.6 1.7 9.2 0.0 4.9 5 0 0 5 5 5 2 Two component regulator propeller DUF1708 PF08101.11 EFA85026.1 - 0.036 13.2 0.3 0.088 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1708) DUF1910 PF08928.10 EFA85026.1 - 0.038 14.0 0.3 0.1 12.6 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) FliE PF02049.18 EFA85026.1 - 0.1 12.8 1.4 0.21 11.8 1.4 1.5 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE YL1 PF05764.13 EFA85027.1 - 0.00056 20.1 3.8 0.00056 20.1 3.8 2.1 2 0 0 2 2 2 1 YL1 nuclear protein EPL1 PF10513.9 EFA85027.1 - 0.0048 17.3 1.8 0.0048 17.3 1.8 2.7 2 1 0 2 2 1 1 Enhancer of polycomb-like Spt20 PF12090.8 EFA85027.1 - 0.04 13.5 43.8 0.021 14.4 13.1 2.2 2 0 0 2 2 2 0 Spt20 family CCSAP PF15748.5 EFA85027.1 - 0.63 10.2 23.5 0.052 13.7 2.8 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated FNIP_N PF14636.6 EFA85027.1 - 0.75 10.8 14.4 0.38 11.7 1.7 2.4 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus Presenilin PF01080.17 EFA85027.1 - 1.3 7.8 26.3 0.053 12.3 1.8 2.1 2 0 0 2 2 2 0 Presenilin PNISR PF15996.5 EFA85027.1 - 1.9 8.7 26.6 0.31 11.3 3.8 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR GAGA_bind PF06217.12 EFA85027.1 - 2 8.6 25.7 1.2 9.3 10.1 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Exonuc_VII_L PF02601.15 EFA85027.1 - 3 7.3 15.9 0.41 10.2 3.4 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Pex14_N PF04695.13 EFA85027.1 - 5.7 7.6 19.3 0.31 11.7 3.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MetallophosC PF16370.5 EFA85027.1 - 6.7 6.9 14.2 0.29 11.4 5.1 2.2 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase RR_TM4-6 PF06459.12 EFA85027.1 - 6.7 6.5 26.8 0.82 9.4 5.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2053 PF09767.9 EFA85028.1 - 0.053 13.7 0.0 0.059 13.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2053) PDGF_N PF04692.13 EFA85028.1 - 0.12 13.1 0.1 0.16 12.7 0.1 1.1 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region Nucleoside_tran PF01733.18 EFA85029.1 - 2.4e-33 115.8 28.0 5.6e-27 94.9 9.5 2.8 1 1 1 2 2 2 2 Nucleoside transporter SpoOE-like PF09388.10 EFA85030.1 - 5 7.1 7.4 8.2 6.4 0.1 3.4 3 2 0 3 3 3 0 Spo0E like sporulation regulatory protein MCM PF00493.23 EFA85031.1 - 1.2e-99 332.0 0.1 2.9e-99 330.7 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain G8 PF10162.9 EFA85031.1 - 4.8e-24 84.8 0.1 1.1e-23 83.7 0.1 1.6 1 0 0 1 1 1 1 G8 domain MCM_lid PF17855.1 EFA85031.1 - 1.2e-19 70.5 0.3 4.4e-19 68.7 0.3 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 EFA85031.1 - 8e-12 45.1 0.8 2.9e-11 43.3 0.8 2.0 1 1 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 EFA85031.1 - 2.4e-11 44.1 0.4 1.3e-10 41.8 0.0 2.6 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFA85031.1 - 4.4e-07 29.5 0.2 0.00011 21.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFA85031.1 - 7.6e-06 26.0 0.0 1.9e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFA85031.1 - 0.01 15.7 0.0 0.035 14.0 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2538 PF10804.8 EFA85031.1 - 0.035 13.9 0.1 0.085 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) TIP41 PF04176.13 EFA85031.1 - 0.035 13.6 0.1 0.1 12.1 0.1 1.7 1 0 0 1 1 1 0 TIP41-like family Neurokinin_B PF03823.14 EFA85031.1 - 0.05 13.6 0.2 14 5.9 0.1 2.7 2 0 0 2 2 2 0 Neurokinin B AAA_lid_2 PF17863.1 EFA85031.1 - 0.15 11.9 0.4 0.69 9.8 0.1 2.1 2 0 0 2 2 2 0 AAA lid domain Beta_helix PF13229.6 EFA85031.1 - 3.1 7.6 17.9 0.38 10.6 5.6 4.1 3 1 0 3 3 2 0 Right handed beta helix region ABC2_membrane PF01061.24 EFA85032.1 - 8.9e-32 110.2 24.1 1.4e-31 109.5 24.1 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFA85032.1 - 1.4e-25 90.4 0.0 2.5e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA85032.1 - 2.1e-05 24.5 5.9 0.0021 17.9 0.1 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA85032.1 - 0.002 18.0 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFA85032.1 - 0.0073 16.7 0.0 0.013 15.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFA85032.1 - 0.0087 16.6 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 EFA85032.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 EFA85032.1 - 0.014 15.1 0.3 0.033 13.9 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EFA85032.1 - 0.019 15.2 0.1 0.036 14.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFA85032.1 - 0.025 14.9 0.5 0.098 12.9 0.5 2.1 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFA85032.1 - 0.027 14.4 0.0 0.059 13.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 EFA85032.1 - 0.036 14.1 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 EFA85032.1 - 0.06 12.8 0.1 7.2 6.0 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF2791 PF10923.8 EFA85032.1 - 0.061 12.2 0.0 0.096 11.5 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) cobW PF02492.19 EFA85032.1 - 0.065 12.8 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EFA85032.1 - 0.07 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain DLIC PF05783.11 EFA85032.1 - 0.07 12.0 0.0 0.099 11.5 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) ABC2_membrane_2 PF12679.7 EFA85032.1 - 0.087 12.1 7.4 0.15 11.3 7.4 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein RNR_Alpha PF17975.1 EFA85033.1 - 3.3e-42 143.1 0.1 1e-41 141.5 0.1 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase alpha domain Ribonuc_red_lgC PF02867.15 EFA85033.1 - 2.2e-09 36.4 2.5 0.0053 15.3 0.0 3.5 3 1 0 4 4 4 3 Ribonucleotide reductase, barrel domain Synuclein PF01387.17 EFA85034.1 - 0.75 10.0 3.7 2.7 8.2 3.7 1.9 1 0 0 1 1 1 0 Synuclein Aminotran_3 PF00202.21 EFA85035.1 - 3.6e-116 388.2 0.0 4.2e-116 387.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFA85035.1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II ARTD15_N PF18084.1 EFA85036.1 - 1.1e-16 60.8 0.0 1.4e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 ARTD15 N-terminal domain PilO PF04350.13 EFA85036.1 - 0.073 13.2 0.0 0.088 13.0 0.0 1.2 1 0 0 1 1 1 0 Pilus assembly protein, PilO PARP PF00644.20 EFA85037.1 - 4.5e-07 29.7 1.7 3.2e-05 23.6 0.5 2.4 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Orf78 PF06024.12 EFA85037.1 - 0.003 17.8 4.6 0.0053 17.0 4.6 1.3 1 0 0 1 1 1 1 Orf78 (ac78) Peptidase_M66 PF10462.9 EFA85038.1 - 3.4e-64 216.7 0.1 4.7e-64 216.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase M66 Metallopep PF12044.8 EFA85038.1 - 0.0037 15.9 0.1 0.0062 15.2 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.6 EFA85038.1 - 0.22 12.0 0.0 0.55 10.8 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like zf-CCHC_3 PF13917.6 EFA85039.1 - 5.1e-05 23.1 0.1 0.00017 21.4 0.1 1.9 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EFA85039.1 - 0.047 13.8 1.3 0.082 13.0 1.3 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 EFA85039.1 - 0.097 12.5 2.5 0.26 11.2 2.5 1.7 1 0 0 1 1 1 0 Zinc knuckle DUF5058 PF16481.5 EFA85040.1 - 0.098 12.3 1.2 0.18 11.4 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5058) An_peroxidase PF03098.15 EFA85041.1 - 2.7e-140 468.5 0.0 3e-140 468.3 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase ATF7IP_BD PF16788.5 EFA85042.1 - 9.4 6.3 7.6 9.8 6.2 7.6 1.1 1 0 0 1 1 1 0 ATF-interacting protein binding domain Pkinase PF00069.25 EFA85043.1 - 7.6e-63 212.3 0.1 1.6e-62 211.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85043.1 - 2e-44 151.8 0.0 3.4e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA85043.1 - 0.00014 21.9 0.0 0.0007 19.6 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA85043.1 - 0.00094 18.1 0.1 0.0021 16.9 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 EFA85043.1 - 0.0033 17.1 0.1 0.0068 16.0 0.1 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 EFA85043.1 - 0.0033 16.8 0.0 0.0093 15.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFA85043.1 - 0.0039 16.6 0.1 0.0068 15.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFA85043.1 - 0.019 13.9 0.2 0.019 13.9 0.2 1.9 2 0 0 2 2 2 0 Haspin like kinase domain HAP1_N PF04849.13 EFA85044.1 - 0.037 13.2 12.9 0.057 12.6 12.9 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region CC2-LZ PF16516.5 EFA85044.1 - 0.056 13.8 12.9 0.057 13.8 7.0 2.5 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Tropomyosin_1 PF12718.7 EFA85044.1 - 0.55 10.4 19.3 0.55 10.4 1.2 2.2 1 1 1 2 2 2 0 Tropomyosin like RasGAP_C PF03836.15 EFA85044.1 - 0.7 10.0 12.4 0.032 14.4 5.1 2.3 2 1 1 3 3 3 0 RasGAP C-terminus UPF0242 PF06785.11 EFA85044.1 - 1.6 8.8 14.3 3 7.9 14.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF5320 PF17253.2 EFA85044.1 - 4.8 8.3 9.1 2.3 9.3 0.1 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5320) Fib_alpha PF08702.10 EFA85044.1 - 5.6 7.2 13.8 1.8 8.8 10.8 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 EFA85044.1 - 7.7 7.2 8.7 9.1 7.0 4.8 2.7 2 1 0 2 2 2 0 SlyX Bcr-Abl_Oligo PF09036.10 EFA85044.1 - 7.8 6.6 10.8 9.4 6.3 2.1 3.0 2 1 2 4 4 4 0 Bcr-Abl oncoprotein oligomerisation domain Syja_N PF02383.18 EFA85045.1 - 1.2e-74 251.5 0.3 1.2e-74 251.5 0.3 2.4 2 0 0 2 2 2 1 SacI homology domain RRM_1 PF00076.22 EFA85046.1 - 7.3e-09 35.3 0.2 3.9e-08 33.0 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRP_L53 PF10780.9 EFA85047.1 - 0.029 14.5 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 39S ribosomal protein L53/MRP-L53 Lipase_3 PF01764.25 EFA85049.1 - 6e-28 97.5 0.0 9e-28 96.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EFA85049.1 - 0.00057 19.5 0.3 0.0039 16.8 0.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) CBM49 PF09478.10 EFA85049.1 - 0.0027 18.0 0.5 0.0075 16.6 0.5 1.8 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Abhydrolase_6 PF12697.7 EFA85049.1 - 0.021 15.5 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EFA85049.1 - 0.034 13.8 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Lipase_3 PF01764.25 EFA85050.1 - 1.1e-46 158.3 0.0 5.8e-31 107.3 0.0 3.2 2 1 1 3 3 3 3 Lipase (class 3) DUF2974 PF11187.8 EFA85050.1 - 0.00035 20.2 0.4 0.0036 16.9 0.4 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 EFA85050.1 - 0.0037 17.9 0.0 0.14 12.8 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family CBM49 PF09478.10 EFA85050.1 - 0.0046 17.2 1.2 0.0097 16.2 1.2 1.5 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Abhydrolase_8 PF06259.12 EFA85050.1 - 0.013 15.1 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_1 PF00561.20 EFA85050.1 - 0.038 13.6 0.1 0.29 10.7 0.0 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFA85050.1 - 0.068 12.6 0.8 0.32 10.4 0.0 2.4 3 0 0 3 3 3 0 Prolyl oligopeptidase family DLH PF01738.18 EFA85050.1 - 0.2 11.2 1.0 7.5 6.0 0.2 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFA85050.1 - 0.21 10.8 0.1 0.45 9.7 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 CBM49 PF09478.10 EFA85051.1 - 0.0021 18.4 1.6 0.0036 17.6 1.6 1.4 1 1 0 1 1 1 1 Carbohydrate binding domain CBM49 VCBS PF13517.6 EFA85052.1 - 3.4e-22 78.8 22.2 9.6e-08 32.5 4.4 5.8 4 2 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Ank_2 PF12796.7 EFA85052.1 - 1.6e-14 54.2 8.9 0.00055 20.5 0.0 6.3 5 1 0 5 5 5 3 Ankyrin repeats (3 copies) FG-GAP PF01839.23 EFA85052.1 - 0.0009 19.3 12.0 2 8.6 0.1 5.5 6 0 0 6 6 6 2 FG-GAP repeat TcdB_toxin_midN PF12256.8 EFA85052.1 - 0.21 10.9 1.0 16 4.8 0.1 2.7 1 1 1 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region dCMP_cyt_deam_1 PF00383.23 EFA85053.1 - 1.1e-12 47.7 0.7 1.7e-12 47.1 0.7 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFA85053.1 - 8.1e-10 38.6 0.2 1.1e-09 38.2 0.2 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EFA85053.1 - 0.013 15.6 2.0 2.4 8.2 0.4 2.4 1 1 1 2 2 2 0 Bd3614-like deaminase SPRY PF00622.28 EFA85054.1 - 1e-10 41.8 0.2 2.1e-10 40.7 0.2 1.6 1 0 0 1 1 1 1 SPRY domain Mucin PF01456.17 EFA85054.1 - 5.1 7.1 37.7 5.7 6.9 27.5 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Det1 PF09737.9 EFA85055.1 - 9.6e-116 387.2 17.8 4.5e-83 279.6 6.2 2.3 1 1 0 2 2 2 2 De-etiolated protein 1 Det1 TSP9 PF11493.8 EFA85055.1 - 0.063 14.0 0.5 0.063 14.0 0.5 2.3 3 0 0 3 3 3 0 Thylakoid soluble phosphoprotein TSP9 Retinal PF15449.6 EFA85056.1 - 5.1 4.8 10.1 4.4 4.9 10.1 1.1 1 0 0 1 1 1 0 Retinal protein Homeodomain PF00046.29 EFA85057.1 - 4.5e-22 77.7 2.7 7.5e-10 38.5 0.1 3.1 2 0 0 2 2 2 2 Homeodomain Homeobox_KN PF05920.11 EFA85057.1 - 0.0018 18.2 7.4 0.35 10.8 0.0 3.8 4 0 0 4 4 4 2 Homeobox KN domain UvdE PF03851.14 EFA85057.1 - 0.003 16.9 1.6 0.0067 15.7 1.6 1.5 1 0 0 1 1 1 1 UV-endonuclease UvdE CENP-B_N PF04218.13 EFA85057.1 - 0.014 15.0 0.2 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain IBN_N PF03810.19 EFA85058.1 - 0.029 14.3 1.1 2.3 8.2 0.1 3.1 2 0 0 2 2 2 0 Importin-beta N-terminal domain DUF402 PF04167.13 EFA85058.1 - 0.031 14.5 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF402) PWI PF01480.17 EFA85059.1 - 0.047 14.0 4.0 0.6 10.5 0.1 3.4 2 1 0 2 2 2 0 PWI domain MRI PF15325.6 EFA85059.1 - 0.59 11.2 3.4 1.7 9.7 3.4 1.7 1 0 0 1 1 1 0 Modulator of retrovirus infection SR-25 PF10500.9 EFA85059.1 - 0.89 9.1 13.6 1.6 8.3 13.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dehydrin PF00257.19 EFA85059.1 - 1.4 9.4 6.5 2.8 8.5 6.5 1.4 1 0 0 1 1 1 0 Dehydrin Zip PF02535.22 EFA85059.1 - 4.4 6.4 6.4 0.55 9.4 2.0 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter PBP1_TM PF14812.6 EFA85059.1 - 4.9 7.6 14.2 24 5.4 10.2 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HA2 PF04408.23 EFA85059.1 - 5.5 7.3 8.3 1 9.6 3.7 2.1 2 0 0 2 2 2 0 Helicase associated domain (HA2) FUN14 PF04930.15 EFA85060.1 - 2.3e-14 53.5 1.1 5.2e-14 52.4 0.0 2.3 3 0 0 3 3 3 1 FUN14 family Phage_holin_3_3 PF16083.5 EFA85060.1 - 0.0021 18.1 0.0 2.2 8.5 0.0 2.5 2 0 0 2 2 2 2 LydA holin phage, holin superfamily III Ago_PAZ PF18309.1 EFA85060.1 - 0.0084 16.7 0.8 0.023 15.3 0.8 1.7 1 0 0 1 1 1 1 Argonaute PAZ domain DUF4365 PF14280.6 EFA85060.1 - 0.057 13.3 1.8 0.078 12.9 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4365) Herpes_UL7 PF01677.16 EFA85060.1 - 0.9 9.2 3.2 15 5.2 0.0 2.7 3 0 0 3 3 3 0 Herpesvirus UL7 like CE2_N PF17996.1 EFA85063.1 - 1.4e-13 50.7 0.0 2.7e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal TLD PF07534.16 EFA85063.1 - 1.1e-10 41.9 0.7 2.3e-10 40.9 0.1 1.9 2 0 0 2 2 2 1 TLD Lipase_GDSL_2 PF13472.6 EFA85063.1 - 4.1e-07 30.6 0.3 1.5e-06 28.8 0.3 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFA85063.1 - 5.8e-06 26.4 0.0 0.00012 22.2 0.0 2.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Dmrt1 PF12374.8 EFA85064.1 - 0.0022 18.4 0.2 0.0027 18.1 0.2 1.1 1 0 0 1 1 1 1 Double-sex mab3 related transcription factor 1 DDE_3 PF13358.6 EFA85065.1 - 5.7e-07 29.4 0.0 2.1e-06 27.6 0.0 2.0 1 1 1 2 2 2 1 DDE superfamily endonuclease YabA PF06156.13 EFA85065.1 - 1.1 9.9 5.4 0.82 10.3 1.8 2.3 2 1 0 2 2 2 0 Initiation control protein YabA CYTH PF01928.21 EFA85066.1 - 4.5e-07 30.0 0.1 6.2e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 CYTH domain NUC PF18510.1 EFA85066.1 - 0.053 14.0 1.8 0.053 14.0 1.8 2.3 2 1 0 2 2 2 0 Nuclease domain HydF_tetramer PF18133.1 EFA85066.1 - 0.11 12.2 0.1 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Hydrogen maturase F tetramerization domain ABC_membrane PF00664.23 EFA85067.1 - 2.8e-52 178.1 29.3 2.3e-28 99.6 12.1 3.2 2 1 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EFA85067.1 - 5.2e-50 169.5 0.1 4.5e-29 101.7 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFA85067.1 - 2.4e-09 36.9 3.5 0.054 12.9 0.2 4.4 2 2 2 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA85067.1 - 1.8e-06 27.6 1.6 0.029 14.1 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFA85067.1 - 5.6e-05 23.2 0.3 0.15 12.2 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA85067.1 - 0.00031 20.7 0.1 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFA85067.1 - 0.00088 19.6 0.8 1.9 8.8 0.3 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFA85067.1 - 0.00093 19.6 0.0 1.4 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EFA85067.1 - 0.0026 17.3 0.3 0.5 9.9 0.2 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 EFA85067.1 - 0.0058 15.8 0.4 1.2 8.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TrwB_AAD_bind PF10412.9 EFA85067.1 - 0.0077 15.2 0.3 0.39 9.6 0.0 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_21 PF13304.6 EFA85067.1 - 0.0087 15.9 3.9 2.6 7.8 0.2 3.6 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA85067.1 - 0.019 14.7 12.2 0.15 11.7 0.0 3.6 4 0 0 4 4 4 0 AAA ATPase domain AAA_27 PF13514.6 EFA85067.1 - 0.027 14.1 0.1 0.17 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFA85067.1 - 0.032 13.5 0.3 5.1 6.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 EFA85067.1 - 0.049 14.1 15.1 0.14 12.7 2.8 3.6 3 1 0 3 3 2 0 AAA domain Nod1 PF17114.5 EFA85067.1 - 0.049 13.8 0.2 7.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 Roc PF08477.13 EFA85067.1 - 0.062 13.5 2.0 16 5.7 0.0 3.4 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EFA85067.1 - 0.092 12.8 1.7 0.17 11.9 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain Sigma54_activat PF00158.26 EFA85067.1 - 0.096 12.4 0.0 7.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 EFA85067.1 - 0.096 12.4 0.5 12 5.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EFA85067.1 - 0.13 12.8 0.8 41 4.7 0.0 3.5 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EFA85067.1 - 0.2 11.0 1.3 8.3 5.7 0.2 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Menin PF05053.13 EFA85067.1 - 2.2 6.6 9.9 3.5 5.9 9.9 1.2 1 0 0 1 1 1 0 Menin Dynamin_N PF00350.23 EFA85067.1 - 6.1 6.9 10.1 1.1 9.3 0.1 3.0 3 0 0 3 3 2 0 Dynamin family PP2C PF00481.21 EFA85068.1 - 7.1e-07 29.1 0.5 0.011 15.4 0.0 2.7 3 1 0 3 3 3 2 Protein phosphatase 2C SpoIIE PF07228.12 EFA85068.1 - 3e-05 24.0 0.0 4.3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Exo84_C PF16528.5 EFA85069.1 - 1.3e-36 126.4 5.0 4.8e-36 124.5 5.0 2.1 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EFA85069.1 - 4.9e-05 23.3 1.4 0.00034 20.6 0.3 3.1 2 0 0 2 2 2 1 Vps51/Vps67 BORCS7 PF16088.5 EFA85069.1 - 0.05 13.9 0.3 1.4 9.2 0.0 3.5 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 Erf4 PF10256.9 EFA85069.1 - 0.11 12.6 0.2 0.11 12.6 0.2 3.3 3 1 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family SapB_2 PF03489.17 EFA85069.1 - 0.21 11.7 0.7 1.4 9.1 0.1 2.9 3 0 0 3 3 3 0 Saposin-like type B, region 2 BP28CT PF08146.12 EFA85069.1 - 0.28 11.0 3.1 1.9 8.3 0.1 3.1 2 1 1 3 3 3 0 BP28CT (NUC211) domain DUF1772 PF08592.11 EFA85070.1 - 8e-15 55.4 0.6 1.1e-14 54.9 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) TauE PF01925.19 EFA85070.1 - 0.093 12.3 0.4 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE DUF684 PF05075.14 EFA85070.1 - 0.11 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF684) DUF1772 PF08592.11 EFA85071.1 - 4.3e-13 49.8 0.9 5.3e-13 49.5 0.7 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) DUF4149 PF13664.6 EFA85071.1 - 0.04 14.2 1.1 0.076 13.4 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) MerC PF03203.14 EFA85071.1 - 0.055 13.9 0.1 0.08 13.4 0.1 1.3 1 0 0 1 1 1 0 MerC mercury resistance protein SLATT_4 PF18186.1 EFA85071.1 - 2.6 7.7 7.0 0.24 11.0 1.2 2.2 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 4 POT1 PF02765.17 EFA85072.1 - 0.034 14.0 0.2 0.074 12.9 0.0 1.6 2 0 0 2 2 2 0 Telomeric single stranded DNA binding POT1/CDC13 Pkinase PF00069.25 EFA85073.1 - 2.3e-48 164.9 0.0 2.8e-48 164.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85073.1 - 9.1e-17 61.2 0.1 1.3e-14 54.1 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA85073.1 - 4.1e-06 25.8 0.0 6e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFA85073.1 - 0.014 14.8 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFA85073.1 - 0.014 14.3 0.1 0.028 13.4 0.1 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFA85073.1 - 0.015 14.4 0.1 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EFA85073.1 - 0.025 14.5 0.2 0.36 10.7 0.5 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family Vpu PF00558.19 EFA85075.1 - 0.077 12.8 3.6 0.17 11.7 3.6 1.6 1 0 0 1 1 1 0 Vpu protein PI3K_1B_p101 PF10486.9 EFA85075.1 - 3.3 5.4 14.6 5.1 4.8 14.6 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Ilm1 PF10311.9 EFA85076.1 - 0.037 13.7 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 UPF0449 PF15136.6 EFA85076.1 - 0.088 13.3 0.5 0.22 12.0 0.5 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Syntaxin-6_N PF09177.11 EFA85076.1 - 0.63 10.6 7.2 1.7 9.2 1.0 3.1 3 0 0 3 3 3 0 Syntaxin 6, N-terminal GCN5L1 PF06320.13 EFA85077.1 - 3.5e-43 146.4 5.4 3.5e-43 146.4 5.4 1.7 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) OTU PF02338.19 EFA85077.1 - 0.089 13.3 0.3 0.15 12.5 0.3 1.4 1 0 0 1 1 1 0 OTU-like cysteine protease DUF948 PF06103.11 EFA85077.1 - 1.4 9.3 6.7 3.6 7.9 0.5 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) MafB19-deam PF14437.6 EFA85078.1 - 4.4e-12 45.9 2.4 8.2e-12 45.0 0.3 2.5 2 1 0 2 2 2 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 EFA85078.1 - 9.5e-12 44.7 0.2 2.2e-11 43.6 0.2 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF4502 PF14950.6 EFA85078.1 - 0.042 13.3 3.3 0.086 12.3 3.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) Lipase_GDSL PF00657.22 EFA85079.1 - 8.4e-06 25.9 0.0 1.7e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Dickkopf_N PF04706.12 EFA85080.1 - 6.8e-09 36.1 50.3 0.00011 22.6 5.5 4.9 3 1 1 4 4 4 4 Dickkopf N-terminal cysteine-rich region EB PF01683.18 EFA85080.1 - 0.025 14.8 8.7 0.025 14.8 8.7 5.8 2 1 3 5 5 5 0 EB module VWA_2 PF13519.6 EFA85082.1 - 6.7e-13 49.2 1.7 3.4e-10 40.5 0.0 3.7 2 1 2 4 4 4 2 von Willebrand factor type A domain UIM PF02809.20 EFA85082.1 - 1.5e-05 24.5 10.9 0.0026 17.6 2.4 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif DUF4362 PF14275.6 EFA85082.1 - 0.0021 18.3 0.1 0.0074 16.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4362) Ssl1 PF04056.14 EFA85082.1 - 0.012 15.5 0.5 0.35 10.7 0.1 2.7 2 1 1 3 3 3 0 Ssl1-like DUF241 PF03087.14 EFA85082.1 - 0.016 15.1 0.3 0.038 13.8 0.3 1.6 1 0 0 1 1 1 0 Arabidopsis protein of unknown function Ank_2 PF12796.7 EFA85083.1 - 2.8e-24 85.5 6.5 1e-14 54.9 1.9 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85083.1 - 4.5e-21 74.9 3.4 9.2e-09 35.7 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85083.1 - 1.4e-20 71.2 5.3 0.00026 21.2 0.1 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EFA85083.1 - 1.3e-19 69.6 10.1 0.00024 21.4 0.4 4.9 4 1 1 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFA85083.1 - 3.6e-17 62.2 7.2 4e-05 23.8 0.4 5.0 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Baculo_PEP_C PF04513.12 EFA85083.1 - 0.0014 18.7 6.1 0.0014 18.7 6.1 1.9 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus LRRFIP PF09738.9 EFA85083.1 - 0.0077 15.7 2.3 0.01 15.3 2.3 1.1 1 0 0 1 1 1 1 LRRFIP family DUF1664 PF07889.12 EFA85083.1 - 0.07 13.2 2.4 0.12 12.4 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PhoU PF01895.19 EFA85083.1 - 0.081 13.4 0.2 0.23 11.9 0.2 1.8 1 0 0 1 1 1 0 PhoU domain FapA PF03961.13 EFA85083.1 - 0.36 9.4 6.4 0.43 9.1 6.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pkinase PF00069.25 EFA85084.1 - 4.5e-40 137.7 12.2 4.2e-35 121.4 0.1 4.1 3 1 2 5 5 5 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85084.1 - 4.4e-18 65.5 0.1 1.6e-16 60.4 0.0 2.7 2 0 0 2 2 2 1 Protein tyrosine kinase zf-RING_2 PF13639.6 EFA85084.1 - 5.2e-07 29.9 6.4 1.3e-06 28.7 6.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA85084.1 - 4.7e-06 26.4 6.5 2.2e-05 24.2 6.5 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA85084.1 - 2.6e-05 24.1 8.5 0.0001 22.2 2.3 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA85084.1 - 0.00041 20.2 6.1 0.0011 18.8 6.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFA85084.1 - 0.0015 18.4 5.7 0.0043 16.9 5.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA85084.1 - 0.0015 18.4 4.9 0.0044 16.9 4.9 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFA85084.1 - 0.0021 17.8 8.5 0.011 15.5 8.6 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FlaC_arch PF05377.11 EFA85084.1 - 0.0068 16.8 1.9 0.0068 16.8 1.9 5.2 5 1 1 6 6 5 1 Flagella accessory protein C (FlaC) Tropomyosin_1 PF12718.7 EFA85084.1 - 0.015 15.4 52.1 0.14 12.3 6.4 4.5 1 1 2 3 3 3 0 Tropomyosin like ERM PF00769.19 EFA85084.1 - 0.15 11.8 57.6 3.3 7.5 40.1 2.6 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Atg14 PF10186.9 EFA85084.1 - 0.22 10.6 43.2 0.024 13.8 7.5 3.0 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 EFA85084.1 - 0.34 10.7 41.9 0.53 10.1 5.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF724) zf-4CXXC_R1 PF10497.9 EFA85084.1 - 0.39 11.0 5.5 0.15 12.3 2.0 2.1 2 0 0 2 2 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C3HC4_4 PF15227.6 EFA85084.1 - 1.3 9.3 6.2 8 6.7 6.2 2.5 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING GAS PF13851.6 EFA85084.1 - 1.3 8.3 52.6 0.029 13.7 16.0 3.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EFA85084.1 - 1.5 9.4 56.9 6 7.4 17.4 3.4 1 1 2 3 3 3 0 Apg6 coiled-coil region zf-RING_11 PF17123.5 EFA85084.1 - 1.8 8.4 12.0 0.24 11.2 5.6 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 EFA85084.1 - 2.5 8.0 12.1 0.32 10.8 5.7 2.6 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EFA85084.1 - 3 8.2 8.2 0.67 10.3 4.1 2.2 2 0 0 2 2 1 0 RING-H2 zinc finger domain Fez1 PF06818.15 EFA85084.1 - 8.2 6.8 47.8 2 8.8 15.5 3.2 1 1 2 3 3 3 0 Fez1 zf-RING_4 PF14570.6 EFA85085.1 - 2.2e-18 65.7 12.6 3.8e-18 65.0 12.6 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EFA85085.1 - 5.8e-07 29.2 0.0 1.8e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EFA85085.1 - 4.3e-06 26.5 9.0 8.3e-06 25.6 9.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EFA85085.1 - 5.4e-05 22.7 2.5 5.4e-05 22.7 2.5 5.6 4 1 1 5 5 3 1 Rtf2 RING-finger Caldesmon PF02029.15 EFA85085.1 - 0.00016 20.6 57.2 0.00016 20.6 57.2 3.2 3 0 0 3 3 3 2 Caldesmon zf-RING_2 PF13639.6 EFA85085.1 - 0.00041 20.6 10.6 0.00076 19.8 10.6 1.5 1 0 0 1 1 1 1 Ring finger domain Utp14 PF04615.13 EFA85085.1 - 0.0063 15.2 72.0 0.0036 16.0 2.9 3.6 3 1 0 3 3 3 2 Utp14 protein Prok-RING_4 PF14447.6 EFA85085.1 - 0.029 14.2 8.4 1.2 9.0 8.8 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFA85085.1 - 0.062 13.2 10.2 0.14 12.1 10.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA85085.1 - 0.12 12.4 9.7 0.25 11.3 9.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFA85085.1 - 0.79 9.6 10.2 1.5 8.7 10.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFA85085.1 - 4.6 7.5 9.5 22 5.3 9.5 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Phospholip_B PF04916.13 EFA85087.1 - 9.3e-191 635.0 6.2 1.1e-190 634.8 6.2 1.0 1 0 0 1 1 1 1 Phospholipase B Sgf11 PF08209.11 EFA85088.1 - 0.059 13.0 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) PRCH PF03967.13 EFA85088.1 - 8 6.7 7.3 0.92 9.7 1.6 2.4 2 0 0 2 2 2 0 Photosynthetic reaction centre, H-chain N-terminal region Peptidase_M8 PF01457.16 EFA85089.1 - 2.8e-53 181.4 3.3 4.9e-53 180.6 3.3 1.3 1 0 0 1 1 1 1 Leishmanolysin Methyltransf_11 PF08241.12 EFA85090.1 - 4.6e-12 46.4 0.1 3.9e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA85090.1 - 8.6e-09 36.0 0.0 4.2e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA85090.1 - 3.8e-07 30.0 0.1 5.1e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA85090.1 - 7e-06 26.7 1.6 8e-06 26.5 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA85090.1 - 0.00028 20.3 0.5 0.00067 19.1 0.5 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFA85090.1 - 0.00052 19.9 0.0 0.00074 19.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EFA85090.1 - 0.0015 17.2 0.0 0.0068 15.0 0.0 1.8 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 EFA85090.1 - 0.0027 17.6 0.4 1.2 8.9 0.0 2.2 1 1 0 2 2 2 2 Hypothetical methyltransferase N6_N4_Mtase PF01555.18 EFA85090.1 - 0.0027 17.4 0.2 0.049 13.3 0.0 2.1 2 0 0 2 2 2 1 DNA methylase DUF3915 PF13054.6 EFA85090.1 - 0.09 12.8 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 EFA85090.1 - 7.2 4.8 6.3 9.8 4.3 6.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family zf-met PF12874.7 EFA85091.1 - 0.00046 20.5 0.4 0.00076 19.8 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFA85091.1 - 0.0091 16.3 0.2 0.015 15.6 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding Zip PF02535.22 EFA85092.1 - 2.2 7.4 9.8 2.8 7.1 9.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CALCOCO1 PF07888.11 EFA85093.1 - 0.0012 17.8 25.9 0.0018 17.2 25.9 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Mis14 PF08641.12 EFA85093.1 - 0.0087 16.4 3.8 0.0087 16.4 3.8 3.7 1 1 2 4 4 4 1 Kinetochore protein Mis14 like Paramyxo_P PF01806.17 EFA85093.1 - 0.011 15.2 2.1 0.011 15.2 2.1 2.7 2 1 1 3 3 3 0 Paramyxovirinae P phosphoprotein C-terminal region ERM PF00769.19 EFA85093.1 - 0.013 15.3 22.7 0.04 13.7 18.5 2.6 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 EFA85093.1 - 0.099 12.7 22.3 0.062 13.3 2.7 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 EFA85093.1 - 0.22 11.7 25.8 0.16 12.2 13.8 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Mto2_bdg PF12808.7 EFA85093.1 - 0.57 10.5 11.2 0.64 10.4 0.3 3.9 4 0 0 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF948 PF06103.11 EFA85093.1 - 0.63 10.3 12.1 33 4.8 2.3 3.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) YkyA PF10368.9 EFA85093.1 - 1.8 8.2 35.4 0.18 11.5 29.0 2.1 1 1 0 2 2 2 0 Putative cell-wall binding lipoprotein MerR-DNA-bind PF09278.11 EFA85093.1 - 3.4 8.3 11.9 5.9 7.5 1.1 3.3 3 1 0 3 3 3 0 MerR, DNA binding KxDL PF10241.9 EFA85093.1 - 4.6 7.6 23.5 0.25 11.7 4.6 3.2 1 1 1 3 3 3 0 Uncharacterized conserved protein YtxH PF12732.7 EFA85093.1 - 6.4 7.4 8.0 4.8e+02 1.4 8.0 3.3 1 1 0 1 1 1 0 YtxH-like protein Phage_GPO PF05929.11 EFA85093.1 - 6.8 6.2 19.7 2.4 7.7 4.2 2.7 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Arm PF00514.23 EFA85095.1 - 5.3e-05 23.1 8.7 0.042 13.9 0.1 6.8 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat NTP_transf_8 PF12281.8 EFA85095.1 - 0.024 14.7 0.0 0.17 11.9 0.0 2.3 3 0 0 3 3 3 0 Nucleotidyltransferase DUF3361 PF11841.8 EFA85095.1 - 0.74 9.7 23.4 0.25 11.3 0.3 5.6 4 1 1 6 6 6 0 Domain of unknown function (DUF3361) RasGEF_N_2 PF14663.6 EFA85095.1 - 0.79 10.1 5.3 12 6.4 0.3 3.7 2 1 2 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain LPD3 PF18798.1 EFA85095.1 - 4.9 7.4 7.7 18 5.6 0.1 3.2 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 3 V-ATPase_H_C PF11698.8 EFA85095.1 - 5 7.3 9.9 19 5.4 0.3 4.3 5 0 0 5 5 5 0 V-ATPase subunit H CHORD PF04968.12 EFA85096.1 - 3.3e-49 165.5 23.6 6.4e-25 87.7 7.9 2.4 2 0 0 2 2 2 2 CHORD CS PF04969.16 EFA85096.1 - 1.3e-10 42.1 3.4 1.3e-10 42.1 3.4 1.6 2 0 0 2 2 2 1 CS domain Imm9 PF15587.6 EFA85096.1 - 0.16 11.6 2.2 0.26 10.9 0.1 2.2 2 1 1 3 3 3 0 Immunity protein 9 DUF3112 PF11309.8 EFA85096.1 - 1.5 8.3 3.7 0.83 9.1 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) Atg8 PF02991.16 EFA85097.1 - 1.7e-32 111.7 0.1 2.1e-32 111.4 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EFA85097.1 - 0.00034 21.0 0.0 0.00045 20.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 FNIP PF05725.12 EFA85099.1 - 9.4e-58 192.1 17.0 4.6e-13 49.1 0.9 9.7 5 2 3 9 9 9 8 FNIP Repeat F-box_5 PF18511.1 EFA85099.1 - 0.0031 17.0 0.1 0.0069 15.9 0.1 1.5 1 0 0 1 1 1 1 F-box SdrD_B PF17210.3 EFA85100.1 - 3.4e-46 156.1 61.3 2.1e-08 34.3 2.0 10.9 9 1 3 12 12 12 8 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA85100.1 - 5.3e-33 113.1 50.9 3e-05 24.2 0.0 11.6 9 2 1 10 10 10 7 Carboxypeptidase regulatory-like domain DUF2012 PF09430.10 EFA85100.1 - 1.1e-21 77.3 4.3 0.00018 21.6 0.1 7.8 8 0 0 8 8 8 6 Protein of unknown function (DUF2012) bMG3 PF11974.8 EFA85100.1 - 1.8e-14 53.6 1.6 0.088 12.8 0.0 8.5 9 0 0 9 9 9 3 Bacterial alpha-2-macroglobulin MG3 domain CarbopepD_reg_2 PF13715.6 EFA85100.1 - 1.5e-12 47.3 30.8 0.049 13.6 0.1 9.6 9 0 0 9 9 9 5 CarboxypepD_reg-like domain TTR-52 PF01060.23 EFA85100.1 - 3.2e-10 40.6 0.7 1.9 9.2 0.0 7.4 6 0 0 6 6 6 3 Transthyretin-like family SpaA PF17802.1 EFA85100.1 - 5.3e-06 26.7 47.0 0.023 15.0 0.2 9.9 8 1 0 8 8 8 3 Prealbumin-like fold domain MetallophosN PF16371.5 EFA85100.1 - 0.022 15.0 11.4 0.49 10.7 0.3 6.5 7 0 0 7 7 7 0 N terminal of Calcineurin-like phosphoesterase Y_Y_Y PF07495.13 EFA85100.1 - 0.05 13.6 12.7 2.2 8.3 0.0 6.2 7 0 0 7 7 7 0 Y_Y_Y domain Dioxygenase_C PF00775.21 EFA85100.1 - 0.059 12.8 2.5 61 3.0 0.0 5.2 7 0 0 7 7 7 0 Dioxygenase APG6_N PF17675.1 EFA85101.1 - 0.27 11.8 25.7 0.032 14.7 9.9 2.9 1 1 1 2 2 2 0 Apg6 coiled-coil region HALZ PF02183.18 EFA85101.1 - 6 7.2 10.0 6.5 7.1 1.3 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper SPG48 PF14764.6 EFA85102.1 - 9.5e-18 64.8 0.3 3.7e-17 62.9 0.0 2.2 2 0 0 2 2 2 1 AP-5 complex subunit, vesicle trafficking Complex1_LYR PF05347.15 EFA85103.1 - 3.2e-07 30.3 2.2 8.7e-07 28.9 2.2 1.8 1 1 0 1 1 1 1 Complex 1 protein (LYR family) COMMD1_N PF17221.3 EFA85103.1 - 0.046 14.0 0.3 0.069 13.4 0.3 1.4 1 1 0 1 1 1 0 COMMD1 N-terminal domain Cytochrome_C7 PF14522.6 EFA85104.1 - 0.24 11.4 8.4 0.55 10.3 0.3 3.7 3 0 0 3 3 3 0 Cytochrome c7 and related cytochrome c HNH PF01844.23 EFA85104.1 - 0.51 10.6 5.0 13 6.1 0.2 3.6 2 0 0 2 2 2 0 HNH endonuclease DZR PF12773.7 EFA85104.1 - 8.5 6.5 8.8 44 4.2 0.2 3.5 3 0 0 3 3 3 0 Double zinc ribbon zf-B_box PF00643.24 EFA85105.1 - 0.001 19.2 8.7 0.0029 17.7 8.7 1.8 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 EFA85105.1 - 0.088 13.1 3.3 0.27 11.5 3.3 1.8 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Laminin_EGF PF00053.24 EFA85106.1 - 0.0001 22.3 22.4 0.0018 18.4 2.5 2.9 3 0 0 3 3 3 2 Laminin EGF domain Nodulin_late PF07127.11 EFA85106.1 - 0.059 13.7 0.4 0.059 13.7 0.4 3.1 2 1 1 3 3 3 0 Late nodulin protein Helicase_C PF00271.31 EFA85106.1 - 0.1 13.0 0.1 0.5 10.7 0.0 2.2 3 0 0 3 3 3 0 Helicase conserved C-terminal domain EGF_2 PF07974.13 EFA85106.1 - 2.5 8.5 19.4 7.2 7.1 7.7 3.0 2 0 0 2 2 2 0 EGF-like domain Mucin PF01456.17 EFA85107.1 - 4.1 7.4 13.0 0.92 9.5 1.8 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein SAP PF02037.27 EFA85108.1 - 0.00037 20.2 0.0 0.0012 18.5 0.0 2.0 1 0 0 1 1 1 1 SAP domain Myc_N PF01056.18 EFA85108.1 - 0.97 9.3 15.4 0.03 14.2 8.4 1.9 2 0 0 2 2 2 0 Myc amino-terminal region DUF913 PF06025.12 EFA85108.1 - 6.4 5.6 8.2 3.5 6.5 6.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Acetyltransf_1 PF00583.25 EFA85109.1 - 1.2e-09 38.4 0.0 2.3e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Lactamase_B_2 PF12706.7 EFA85109.1 - 1.8e-07 30.9 0.0 2.9e-06 26.9 0.0 2.4 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Acetyltransf_10 PF13673.7 EFA85109.1 - 3.7e-06 26.9 0.0 1e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA85109.1 - 4.8e-05 23.7 0.0 0.00014 22.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA85109.1 - 0.007 17.1 0.1 0.016 15.9 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Lactamase_B_4 PF13691.6 EFA85109.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease Acetyltransf_8 PF13523.6 EFA85109.1 - 0.16 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA85110.1 - 2.6e-06 27.6 0.1 4.7e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA85110.1 - 0.00018 21.9 0.1 0.00033 21.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA85110.1 - 0.0015 18.5 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA85110.1 - 0.017 15.8 0.1 0.028 15.1 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Gifsy-2 PF13856.6 EFA85110.1 - 0.017 15.4 0.1 0.055 13.8 0.1 1.8 2 0 0 2 2 2 0 ATP-binding sugar transporter from pro-phage Ubiquitin_5 PF18037.1 EFA85110.1 - 0.41 11.0 2.2 0.35 11.2 0.3 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain DUF3168 PF11367.8 EFA85111.1 - 0.041 14.1 0.0 0.051 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3168) PhoLip_ATPase_C PF16212.5 EFA85112.1 - 4.6e-71 239.5 30.0 4.6e-71 239.5 30.0 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EFA85112.1 - 2.3e-14 53.2 0.1 3e-12 46.4 0.1 2.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFA85112.1 - 4.1e-12 46.8 1.6 3.8e-06 27.3 0.4 3.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 EFA85112.1 - 3.1e-07 30.0 0.2 2e-06 27.4 0.2 2.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFA85112.1 - 5e-06 26.2 5.2 2.4e-05 23.9 0.2 3.5 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFA85112.1 - 0.0015 18.4 0.0 0.0015 18.4 0.0 3.7 3 1 1 4 4 4 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA85112.1 - 0.0033 17.8 0.0 0.25 11.7 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Glyco_hydro_39 PF01229.17 EFA85113.1 - 2.2e-111 372.8 1.1 5.6e-111 371.5 1.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 39 FNIP PF05725.12 EFA85114.1 - 6.1e-23 80.7 33.4 8.9e-10 38.6 0.0 8.6 7 2 3 10 10 10 7 FNIP Repeat AIRC PF00731.20 EFA85115.1 - 0.0066 16.0 1.4 2.5 7.6 0.1 3.1 1 1 2 3 3 3 2 AIR carboxylase Dapper PF15268.6 EFA85116.1 - 0.024 13.6 35.3 0.032 13.1 35.3 1.4 1 0 0 1 1 1 0 Dapper MAP7 PF05672.11 EFA85116.1 - 0.29 10.8 67.9 0.095 12.4 59.8 2.2 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Hamartin PF04388.12 EFA85116.1 - 1.3 7.6 36.6 1.5 7.4 36.6 1.1 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 EFA85116.1 - 5.9 3.9 35.4 7.3 3.6 35.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nucleoporin_FG PF13634.6 EFA85118.1 - 1e-39 135.2 288.2 1.5e-10 41.8 17.9 18.3 10 5 6 16 16 16 12 Nucleoporin FG repeat region zf-RanBP PF00641.18 EFA85118.1 - 6.3e-10 38.2 68.6 0.0029 16.9 9.7 5.5 5 0 0 5 5 5 5 Zn-finger in Ran binding protein and others SUIM_assoc PF16619.5 EFA85118.1 - 0.0015 18.6 0.3 0.0015 18.6 0.3 4.8 4 0 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 OTU PF02338.19 EFA85119.1 - 2e-15 57.4 0.1 2e-15 57.4 0.1 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFA85119.1 - 0.0012 18.4 0.2 0.057 12.9 0.0 3.1 3 1 0 3 3 2 2 Peptidase C65 Otubain UBA PF00627.31 EFA85119.1 - 0.0028 17.5 0.0 0.0065 16.4 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Spt20 PF12090.8 EFA85119.1 - 0.0061 16.2 25.8 0.0061 16.2 25.8 2.0 3 0 0 3 3 3 1 Spt20 family Dicty_REP PF05086.12 EFA85119.1 - 0.0065 14.5 19.5 0.01 13.9 19.5 1.2 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein CUE PF02845.16 EFA85119.1 - 0.033 13.9 0.1 0.072 12.8 0.1 1.5 1 0 0 1 1 1 0 CUE domain Hid1 PF12722.7 EFA85119.1 - 0.048 11.8 9.5 0.056 11.6 9.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UBA_4 PF14555.6 EFA85119.1 - 0.064 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain Presenilin PF01080.17 EFA85119.1 - 0.13 11.0 17.5 0.22 10.3 17.5 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EFA85119.1 - 0.15 10.3 11.0 0.21 9.8 11.0 1.3 1 0 0 1 1 1 0 CDC45-like protein SprA-related PF12118.8 EFA85119.1 - 0.49 9.5 22.3 0.78 8.8 22.3 1.2 1 0 0 1 1 1 0 SprA-related family SLC12 PF03522.15 EFA85119.1 - 0.51 9.3 14.2 0.84 8.6 14.2 1.5 1 0 0 1 1 1 0 Solute carrier family 12 Med3 PF11593.8 EFA85119.1 - 6.5 5.8 31.2 0.021 14.0 17.0 2.3 1 1 1 2 2 2 0 Mediator complex subunit 3 fungal ALMT PF11744.8 EFA85119.1 - 6.7 5.4 11.8 9.8 4.9 11.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 EFA85119.1 - 8.6 5.2 14.5 19 4.0 14.5 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Serinc PF03348.15 EFA85119.1 - 9.2 5.1 6.6 13 4.6 6.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) FMO-like PF00743.19 EFA85121.1 - 4.3e-38 131.0 0.1 3.4e-20 72.0 0.0 2.9 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFA85121.1 - 1.2e-08 34.6 0.0 1.1e-05 24.8 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFA85121.1 - 3.1e-08 33.7 0.1 1.7e-05 24.9 0.0 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFA85121.1 - 2.1e-05 23.9 0.0 0.0022 17.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA85121.1 - 0.00012 21.8 0.0 0.38 10.3 0.0 3.0 2 1 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFA85121.1 - 0.0035 16.5 0.1 0.081 12.0 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFA85121.1 - 0.0036 17.5 0.1 0.016 15.4 0.1 2.1 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Prenylcys_lyase PF07156.14 EFA85121.1 - 0.009 15.2 0.1 0.015 14.5 0.1 1.3 1 0 0 1 1 1 1 Prenylcysteine lyase HI0933_like PF03486.14 EFA85121.1 - 0.046 12.4 0.1 0.1 11.3 0.0 1.5 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EFA85121.1 - 0.15 12.6 0.0 0.45 11.1 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase zf-Mss51 PF13824.6 EFA85122.1 - 0.034 14.3 0.1 0.039 14.1 0.1 1.1 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Myb_DNA-binding PF00249.31 EFA85124.1 - 1.1e-21 76.7 0.1 1e-10 41.6 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain SWIRM PF04433.17 EFA85124.1 - 1.4e-19 70.2 0.0 4.2e-19 68.7 0.0 1.9 1 0 0 1 1 1 1 SWIRM domain JAB PF01398.21 EFA85124.1 - 2e-10 40.7 0.0 2e-10 40.7 0.0 3.9 4 0 0 4 4 4 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myb_DNA-bind_6 PF13921.6 EFA85124.1 - 1.5e-09 37.9 2.9 3e-05 24.2 0.7 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain Prok-JAB PF14464.6 EFA85124.1 - 9.3e-08 31.9 0.2 9.3e-08 31.9 0.2 2.5 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_7 PF15963.5 EFA85124.1 - 5.5e-06 26.2 2.8 5.5e-06 26.2 2.8 4.9 4 0 0 4 4 4 2 Myb DNA-binding like CSRNP_N PF16019.5 EFA85124.1 - 0.0038 17.2 0.4 0.0038 17.2 0.4 8.4 4 2 4 9 9 9 1 Cysteine/serine-rich nuclear protein N-terminus ResIII PF04851.15 EFA85125.1 - 3.1e-06 27.3 0.1 3.1e-06 27.3 0.1 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EFA85125.1 - 0.0041 16.8 5.6 0.019 14.6 0.1 2.3 2 0 0 2 2 2 2 SWI2/SNF2 ATPase Androgen_recep PF02166.16 EFA85126.1 - 0.081 11.7 15.1 0.65 8.8 2.7 2.2 2 0 0 2 2 2 0 Androgen receptor Asp PF00026.23 EFA85127.1 - 1.2e-30 107.0 0.4 2e-30 106.3 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFA85127.1 - 6.1e-10 39.6 1.2 1.1e-09 38.8 1.2 1.4 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EFA85127.1 - 2e-05 24.4 0.0 5.5e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TPR_2 PF07719.17 EFA85129.1 - 0.005 16.8 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA85129.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Pex14_N PF04695.13 EFA85129.1 - 0.041 14.5 14.8 0.052 14.2 14.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ASD2 PF08687.11 EFA85129.1 - 0.064 12.8 6.3 0.078 12.5 6.3 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 DUF3086 PF11285.8 EFA85129.1 - 0.17 10.9 5.4 0.21 10.7 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) MAS20 PF02064.15 EFA85129.1 - 0.27 11.3 8.4 5.1 7.2 0.0 2.1 1 1 1 2 2 2 0 MAS20 protein import receptor AI-2E_transport PF01594.16 EFA85129.1 - 0.8 8.8 3.9 0.99 8.5 3.9 1.0 1 0 0 1 1 1 0 AI-2E family transporter WBP-1 PF11669.8 EFA85129.1 - 1.6 9.4 6.7 2.6 8.7 6.7 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 Presenilin PF01080.17 EFA85129.1 - 2.1 7.0 8.2 2.2 7.0 8.2 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFA85129.1 - 2.4 7.3 4.2 2.7 7.1 4.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 EFA85129.1 - 3.3 6.5 4.9 3.1 6.5 4.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PAXNEB PF05625.11 EFA85131.1 - 3.3e-93 312.8 0.0 5.7e-93 312.0 0.0 1.3 1 1 0 1 1 1 1 PAXNEB protein Rad51 PF08423.11 EFA85131.1 - 0.078 12.2 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Rad51 ATPase PF06745.13 EFA85131.1 - 0.08 12.3 0.1 0.49 9.7 0.0 2.0 2 0 0 2 2 2 0 KaiC Fungus-induced PF10917.8 EFA85132.1 - 0.083 13.2 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Fungus-induced protein HAT PF02184.16 EFA85133.1 - 9.1e-23 79.9 58.3 5.2e-10 39.1 0.1 12.9 12 3 0 12 12 12 6 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 EFA85133.1 - 1.9e-14 53.1 5.3 0.15 12.9 0.0 9.2 4 4 6 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFA85133.1 - 8e-12 45.5 0.0 0.47 11.0 0.0 6.0 5 2 0 5 5 5 3 Tetratricopeptide repeat Suf PF05843.14 EFA85133.1 - 1.7e-09 38.1 24.9 1.2e-06 28.8 0.2 6.0 1 1 4 5 5 5 4 Suppressor of forked protein (Suf) TPR_16 PF13432.6 EFA85133.1 - 1e-07 32.5 0.2 0.056 14.1 0.0 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA85133.1 - 7.4e-07 29.4 7.7 15 6.5 0.0 8.6 10 1 1 11 11 10 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA85133.1 - 4.4e-05 23.6 1.5 0.0053 17.0 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85133.1 - 9.8e-05 22.2 5.6 20 5.6 0.1 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFA85133.1 - 0.00011 22.2 0.2 0.3 11.3 0.0 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA85133.1 - 0.00012 22.0 0.1 53 4.4 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFA85133.1 - 0.00024 21.1 25.1 0.03 14.3 3.1 7.0 5 2 2 7 7 7 3 Mad3/BUB1 homology region 1 TPR_MalT PF17874.1 EFA85133.1 - 0.032 13.6 0.0 0.076 12.4 0.0 1.5 1 0 0 1 1 1 0 MalT-like TPR region TPR_12 PF13424.6 EFA85133.1 - 0.19 12.1 2.4 20 5.6 0.0 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat Secretin_N_2 PF07655.13 EFA85134.1 - 0.26 11.8 18.6 4.3 7.9 0.1 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain NST1 PF13945.6 EFA85134.1 - 0.71 9.9 14.5 1.3 9.0 14.5 1.5 1 1 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 EFA85134.1 - 2.9 6.5 8.5 3.1 6.5 8.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4512 PF14975.6 EFA85134.1 - 6.5 7.6 8.3 1.4 9.7 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) zf-MYND PF01753.18 EFA85135.1 - 2.7e-08 33.7 10.0 6e-08 32.7 10.0 1.6 1 0 0 1 1 1 1 MYND finger Med3 PF11593.8 EFA85135.1 - 0.0027 17.0 6.7 0.0027 17.0 6.7 4.8 4 1 1 5 5 5 1 Mediator complex subunit 3 fungal MecA PF05389.12 EFA85135.1 - 0.031 13.9 8.1 0.85 9.2 3.9 2.7 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) PA26 PF04636.13 EFA85135.1 - 0.56 9.1 4.5 1.4 7.7 4.5 1.7 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Zip PF02535.22 EFA85135.1 - 8 5.6 9.4 2.5 7.3 4.6 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter EGF_2 PF07974.13 EFA85136.1 - 0.00041 20.7 29.2 0.11 12.9 10.6 2.7 2 0 0 2 2 2 2 EGF-like domain YcaO_C PF18381.1 EFA85136.1 - 0.0061 16.5 1.1 3.6 7.5 0.1 2.3 2 0 0 2 2 2 2 YcaO cyclodehydratase C-terminal domain RRM_2 PF04059.12 EFA85136.1 - 0.051 13.8 3.2 7 6.9 0.2 2.9 2 0 0 2 2 2 0 RNA recognition motif 2 EB PF01683.18 EFA85136.1 - 0.052 13.8 13.9 1.1 9.6 3.0 2.4 2 0 0 2 2 2 0 EB module Dynein_attach_N PF15867.5 EFA85136.1 - 0.18 11.8 0.0 6.7 6.8 0.0 2.4 2 0 0 2 2 2 0 Dynein attachment factor N-terminus Glyco_hydro_49 PF03718.13 EFA85136.1 - 0.21 11.6 18.0 0.73 9.8 1.7 4.9 4 0 0 4 4 4 0 Glycosyl hydrolase family 49 DUF3781 PF12636.7 EFA85136.1 - 2.2 8.3 7.1 28 4.7 0.7 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3781) EGF_2 PF07974.13 EFA85137.1 - 0.02 15.3 10.6 0.049 14.0 10.6 1.7 1 0 0 1 1 1 0 EGF-like domain Glyco_hydro_49 PF03718.13 EFA85137.1 - 0.41 10.6 5.4 0.23 11.5 1.8 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 49 EGF PF00008.27 EFA85137.1 - 1.4 9.3 10.0 2.6 8.4 10.0 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA85138.1 - 0.021 15.2 10.6 0.051 13.9 10.6 1.7 1 0 0 1 1 1 0 EGF-like domain EphA2_TM PF14575.6 EFA85138.1 - 0.097 13.6 0.3 0.17 12.8 0.3 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5518 PF17647.1 EFA85138.1 - 0.11 12.7 0.2 0.11 12.7 0.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5518) Glyco_hydro_49 PF03718.13 EFA85138.1 - 2.3 8.2 8.8 0.34 10.9 1.7 3.3 3 0 0 3 3 3 0 Glycosyl hydrolase family 49 IBR PF01485.21 EFA85139.1 - 2.3e-17 63.0 39.6 4e-11 43.0 7.9 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFA85139.1 - 1.7e-06 27.8 8.9 1.7e-06 27.8 8.9 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA85139.1 - 1.2e-05 25.6 6.7 1.2e-05 25.6 6.7 3.8 3 1 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EFA85139.1 - 5.4e-05 23.1 3.9 5.4e-05 23.1 3.9 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFA85139.1 - 0.0008 19.2 4.4 0.0008 19.2 4.4 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA85139.1 - 0.0035 17.3 8.1 0.0035 17.3 8.1 3.7 4 0 0 4 4 4 1 zinc-RING finger domain zf-RING_11 PF17123.5 EFA85139.1 - 0.014 15.2 4.8 0.014 15.2 4.8 2.7 2 0 0 2 2 2 0 RING-like zinc finger DUF61 PF01886.16 EFA85139.1 - 0.18 11.8 1.8 0.47 10.5 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF61 C1_4 PF07975.12 EFA85139.1 - 0.25 11.6 21.3 0.24 11.6 6.5 3.4 2 1 0 2 2 2 0 TFIIH C1-like domain GTP_EFTU PF00009.27 EFA85140.1 - 3.9e-58 196.2 0.5 7.5e-58 195.3 0.5 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFA85140.1 - 7.6e-15 54.7 0.0 2.1e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFA85140.1 - 1.3e-09 38.3 0.0 3.8e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFA85140.1 - 1.4e-09 37.9 0.2 1.7e-08 34.4 0.1 2.4 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_IV PF03764.18 EFA85140.1 - 2.9e-05 23.8 0.0 0.003 17.3 0.0 2.8 2 0 0 2 2 2 1 Elongation factor G, domain IV Ureide_permease PF07168.11 EFA85140.1 - 0.12 11.1 0.6 0.34 9.6 0.6 1.7 1 0 0 1 1 1 0 Ureide permease EAP30 PF04157.16 EFA85141.1 - 1.7e-18 66.8 6.3 4.3e-15 55.7 1.7 4.6 4 1 1 5 5 5 2 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 EFA85141.1 - 1.1e-14 54.4 0.1 3.8e-14 52.6 0.1 2.0 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Synaptobrevin PF00957.21 EFA85141.1 - 1.5e-05 24.7 2.3 1.5e-05 24.7 2.3 2.5 2 0 0 2 2 2 1 Synaptobrevin ANAPC4_WD40 PF12894.7 EFA85141.1 - 9.2e-05 22.7 0.1 14 6.0 0.0 5.5 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain SUIM_assoc PF16619.5 EFA85141.1 - 0.025 14.6 0.6 0.025 14.6 0.6 6.5 4 3 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 EFA85141.1 - 0.17 12.8 1.5 89 4.2 0.1 4.6 4 0 0 4 4 4 0 WD domain, G-beta repeat Peptidase_C97 PF05903.14 EFA85142.1 - 5.9e-36 123.6 0.2 8.7e-36 123.0 0.2 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain SVIP PF15811.5 EFA85142.1 - 0.0029 18.0 0.4 0.016 15.7 0.1 2.1 2 0 0 2 2 2 1 Small VCP/p97-interacting protein CDC45 PF02724.14 EFA85142.1 - 1.6 6.9 9.8 2.3 6.4 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein XAP5 PF04921.14 EFA85142.1 - 5.2 6.8 7.7 8.7 6.1 7.7 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator LIM PF00412.22 EFA85143.1 - 5.6e-30 103.4 37.8 1.5e-15 57.1 3.7 4.0 2 1 2 4 4 4 3 LIM domain zf_C2H2_13 PF18508.1 EFA85143.1 - 0.0053 16.3 7.1 2.8 7.6 0.3 4.1 2 1 1 3 3 3 2 Zinc finger domain DisA_N PF02457.16 EFA85143.1 - 0.0057 16.2 0.0 0.01 15.4 0.0 1.4 1 1 0 1 1 1 1 DisA bacterial checkpoint controller nucleotide-binding Zn_ribbon_SprT PF17283.2 EFA85143.1 - 0.31 11.0 0.1 0.31 11.0 0.1 4.5 6 0 0 6 6 6 0 SprT-like zinc ribbon domain TNFR_c6 PF00020.18 EFA85143.1 - 0.62 10.5 0.2 0.62 10.5 0.2 7.5 4 1 3 7 7 7 0 TNFR/NGFR cysteine-rich region XPA_N PF01286.18 EFA85143.1 - 1.1 9.4 0.0 1.1 9.4 0.0 7.2 9 0 0 9 9 9 0 XPA protein N-terminal WD40 PF00400.32 EFA85144.1 - 4.4e-64 210.9 12.5 7.9e-10 39.2 0.9 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EFA85144.1 - 1.3e-25 89.5 12.0 1.3e-25 89.5 12.0 2.0 2 0 0 2 2 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EFA85144.1 - 1.7e-23 82.7 0.0 0.00013 22.2 0.0 6.4 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA85144.1 - 9.2e-11 41.3 0.1 0.17 10.8 0.0 5.6 2 2 1 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFA85144.1 - 2e-07 31.1 0.0 0.016 15.1 0.0 4.1 1 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFA85144.1 - 3.8e-07 29.7 0.0 0.2 10.9 0.0 4.6 5 0 0 5 5 5 2 WD40-like domain PD40 PF07676.12 EFA85144.1 - 4.4e-06 26.5 0.1 2.3 8.3 0.0 4.8 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EFA85144.1 - 2.7e-05 23.7 0.1 0.25 10.6 0.0 3.6 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 EFA85144.1 - 2.9e-05 22.8 0.2 0.0014 17.2 0.1 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain Frtz PF11768.8 EFA85144.1 - 0.0041 15.5 0.0 2 6.6 0.0 3.2 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Caudo_TAP PF02413.17 EFA85144.1 - 0.067 13.3 5.0 0.2 11.8 5.0 1.8 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Nup160 PF11715.8 EFA85144.1 - 0.071 11.7 0.3 24 3.4 0.0 3.7 2 1 2 5 5 5 0 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 EFA85144.1 - 0.2 11.4 3.2 85 3.0 0.0 4.4 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF913 PF06025.12 EFA85144.1 - 0.22 10.5 3.9 0.32 9.9 3.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIA PF03153.13 EFA85144.1 - 0.23 11.4 25.9 0.31 11.0 25.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tho2 PF11262.8 EFA85144.1 - 1.5 8.0 6.1 6 6.0 0.3 2.3 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 RAB3GAP2_N PF14655.6 EFA85144.1 - 2.7 7.2 7.0 2.1e+02 0.9 0.0 3.3 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus SHE3 PF17078.5 EFA85144.1 - 4 7.1 14.2 0.026 14.2 4.9 2.0 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF4834 PF16118.5 EFA85144.1 - 5.7 8.0 6.6 18 6.4 6.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Suf PF05843.14 EFA85144.1 - 6.4 6.7 15.9 10 6.0 15.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) LMBR1 PF04791.16 EFA85144.1 - 7.3 5.4 5.9 10 4.9 5.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein UPRTase PF14681.6 EFA85146.1 - 3.8e-80 268.2 0.0 4.3e-80 268.0 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFA85146.1 - 5.1e-08 32.6 0.0 1.1e-07 31.6 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain ANAPC4_WD40 PF12894.7 EFA85147.1 - 5.9e-05 23.3 0.2 0.48 10.7 0.0 3.7 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_3 PF15911.5 EFA85147.1 - 0.0031 17.5 0.0 6.1 6.9 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 EFA85147.1 - 0.026 15.4 2.2 7.6 7.6 0.0 4.3 6 0 0 6 6 6 0 WD domain, G-beta repeat CPSF_A PF03178.15 EFA85147.1 - 0.055 12.8 0.1 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 CPSF A subunit region Ge1_WD40 PF16529.5 EFA85147.1 - 0.099 11.6 0.0 0.31 10.0 0.0 1.8 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PLDc_2 PF13091.6 EFA85148.1 - 2.4e-37 127.8 0.2 2.3e-19 69.6 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.6 EFA85148.1 - 8.4e-32 110.2 0.8 1.7e-30 106.0 0.3 2.4 2 0 0 2 2 2 1 PLD-like domain PLDc PF00614.22 EFA85148.1 - 2.1e-11 43.5 1.8 2.8e-07 30.4 0.4 3.0 3 0 0 3 3 3 2 Phospholipase D Active site motif FliC_SP PF12613.8 EFA85148.1 - 6 7.5 9.1 13 6.4 1.1 3.0 2 1 0 2 2 2 0 Flagellin structural protein ATG13 PF10033.9 EFA85149.1 - 5.6e-17 62.2 12.1 8.2e-16 58.4 0.2 3.4 3 0 0 3 3 3 2 Autophagy-related protein 13 TFIIA PF03153.13 EFA85149.1 - 7.7 6.4 61.5 1.2 9.0 8.8 2.6 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ABC2_membrane PF01061.24 EFA85150.1 - 2.2e-73 246.2 47.2 9.1e-39 133.1 19.8 3.2 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 EFA85150.1 - 4.3e-47 160.1 0.0 6.1e-23 81.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 EFA85150.1 - 2.2e-07 31.4 0.0 0.025 14.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 EFA85150.1 - 4e-07 30.6 0.0 0.0096 16.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFA85150.1 - 8.8e-07 28.6 0.3 0.002 17.8 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFA85150.1 - 2.3e-05 24.4 0.9 0.00054 19.9 0.2 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EFA85150.1 - 2.4e-05 24.5 0.0 0.1 12.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain PDR_assoc PF08370.11 EFA85150.1 - 5.3e-05 22.9 3.0 0.00093 18.9 0.2 3.2 2 0 0 2 2 2 1 Plant PDR ABC transporter associated Rad17 PF03215.15 EFA85150.1 - 6e-05 23.1 0.0 0.0092 15.9 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain PDR_CDR PF06422.12 EFA85150.1 - 7.3e-05 22.6 3.5 0.008 16.1 0.2 3.1 2 0 0 2 2 2 1 CDR ABC transporter AAA_22 PF13401.6 EFA85150.1 - 0.00013 22.2 0.0 0.18 12.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFA85150.1 - 0.00016 21.9 0.1 0.36 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EFA85150.1 - 0.00031 20.7 0.1 1 9.1 0.1 3.4 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFA85150.1 - 0.00058 19.9 0.3 0.81 9.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.6 EFA85150.1 - 0.0018 17.9 0.0 0.58 9.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFA85150.1 - 0.0043 17.0 0.2 0.8 9.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EFA85150.1 - 0.011 16.1 0.0 10 6.6 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.6 EFA85150.1 - 0.012 16.0 0.1 6.1 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFA85150.1 - 0.015 15.7 0.1 11 6.5 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ploopntkinase3 PF18751.1 EFA85150.1 - 0.024 14.6 0.1 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 TsaE PF02367.17 EFA85150.1 - 0.055 13.5 0.1 7.4 6.6 0.2 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EFA85150.1 - 0.061 12.9 1.3 0.13 11.8 0.2 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 EFA85150.1 - 0.062 12.6 0.2 7.1 5.8 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin Cytidylate_kin PF02224.18 EFA85150.1 - 0.067 12.9 0.7 1.2 8.8 0.1 2.8 3 0 0 3 3 3 0 Cytidylate kinase CPT PF07931.12 EFA85150.1 - 0.095 12.5 0.9 0.6 9.9 0.1 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.6 EFA85150.1 - 0.23 11.1 0.3 5.3 6.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFA85150.1 - 0.33 11.4 2.0 1.7 9.1 0.0 2.8 2 1 1 3 3 3 0 AAA domain AAA_5 PF07728.14 EFA85150.1 - 0.38 10.8 2.2 13 5.8 0.1 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ABC2_membrane_3 PF12698.7 EFA85150.1 - 2.5 7.1 46.4 0.0037 16.4 8.1 3.5 3 1 0 3 3 3 0 ABC-2 family transporter protein MMR_HSR1 PF01926.23 EFA85151.1 - 8.6e-05 22.6 0.8 0.00029 20.9 0.1 2.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase GBP PF02263.19 EFA85151.1 - 0.00013 21.4 0.9 0.00037 19.9 0.0 2.1 2 1 1 3 3 3 1 Guanylate-binding protein, N-terminal domain Diphthamide_syn PF01866.17 EFA85151.1 - 0.024 14.1 0.2 0.043 13.2 0.2 1.4 1 0 0 1 1 1 0 Putative diphthamide synthesis protein p450 PF00067.22 EFA85152.1 - 4.4e-101 338.9 0.1 5e-101 338.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 HEAT PF02985.22 EFA85153.1 - 6e-44 144.3 22.3 0.00059 19.9 0.0 14.3 15 0 0 15 15 15 11 HEAT repeat HEAT_2 PF13646.6 EFA85153.1 - 5.1e-39 132.5 0.2 2.5e-10 40.6 0.0 7.1 2 1 6 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 EFA85153.1 - 9.4e-12 45.2 7.6 0.4 11.3 0.1 8.3 6 3 2 8 8 8 5 HEAT-like repeat Adaptin_N PF01602.20 EFA85153.1 - 1.5e-11 43.6 6.7 7.7e-08 31.3 1.9 2.9 2 1 0 2 2 2 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 EFA85153.1 - 4.9e-10 39.9 2.6 0.22 12.2 0.0 6.8 3 2 4 7 7 6 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EFA85153.1 - 6.3e-10 39.3 9.0 0.0032 17.5 0.6 4.9 2 1 2 4 4 4 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EFA85153.1 - 1.5e-08 34.5 2.8 0.0059 16.2 0.2 5.5 2 2 0 3 3 3 1 CLASP N terminal Arm PF00514.23 EFA85153.1 - 4.9e-06 26.4 0.8 27 5.0 0.0 7.1 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EFA85153.1 - 0.00027 21.1 5.3 2.6 8.2 0.0 4.7 4 1 2 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_N PF03224.14 EFA85153.1 - 0.0017 17.7 7.3 0.78 9.0 0.6 4.0 2 1 2 4 4 4 3 V-ATPase subunit H IFRD PF05004.13 EFA85153.1 - 0.0065 15.6 2.7 0.12 11.4 0.3 3.5 2 1 1 4 4 4 1 Interferon-related developmental regulator (IFRD) V-ATPase_H_C PF11698.8 EFA85153.1 - 0.037 14.1 0.3 1.9 8.7 0.0 3.0 2 0 0 2 2 2 0 V-ATPase subunit H Mo25 PF08569.11 EFA85153.1 - 0.063 12.6 0.6 1.1 8.6 0.2 2.6 2 1 0 2 2 2 0 Mo25-like HEAT_PBS PF03130.16 EFA85153.1 - 0.079 13.7 0.0 24 6.0 0.0 4.2 4 0 0 4 4 2 0 PBS lyase HEAT-like repeat DUF3535 PF12054.8 EFA85153.1 - 0.13 11.5 1.5 3.1 7.0 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3535) Granulin PF00396.18 EFA85154.1 - 7.3e-12 45.4 24.9 2.5e-11 43.7 20.1 2.2 2 0 0 2 2 2 1 Granulin DUF4134 PF13572.6 EFA85154.1 - 0.045 14.0 0.0 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) Conotoxin PF02950.17 EFA85154.1 - 0.12 13.4 14.9 50 5.0 14.9 2.3 1 1 0 1 1 1 0 Conotoxin Fungus-induced PF10917.8 EFA85154.1 - 0.22 11.8 0.1 0.22 11.8 0.1 2.1 2 0 0 2 2 2 0 Fungus-induced protein zf-RING_2 PF13639.6 EFA85155.1 - 7.9e-13 48.5 7.4 7.9e-13 48.5 7.4 2.1 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 EFA85155.1 - 4e-10 39.3 5.3 8.1e-10 38.3 5.3 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFA85155.1 - 2.3e-07 30.5 5.7 6.1e-07 29.2 5.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA85155.1 - 2.5e-06 27.2 6.4 2.5e-06 27.2 6.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA85155.1 - 3.5e-06 27.2 8.0 3.5e-06 27.2 8.0 2.3 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA85155.1 - 9.3e-06 25.4 3.6 9.3e-06 25.4 3.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA85155.1 - 1.4e-05 24.9 3.9 1.4e-05 24.9 3.9 1.9 2 0 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFA85155.1 - 1.8e-05 24.5 5.0 5.2e-05 23.0 5.0 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFA85155.1 - 0.00013 21.9 2.9 0.00047 20.1 2.9 2.0 1 1 0 1 1 1 1 RING-type zinc-finger DUF3439 PF11921.8 EFA85155.1 - 0.11 12.4 11.1 0.29 11.1 11.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FANCL_C PF11793.8 EFA85155.1 - 0.18 12.0 7.2 3.4 7.9 7.2 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain DUF4512 PF14975.6 EFA85155.1 - 8.6 7.2 7.4 2.9 8.7 1.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Pkinase PF00069.25 EFA85156.1 - 4.8e-64 216.3 1.1 5.1e-63 212.9 1.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85156.1 - 1.5e-28 99.8 2.5 4.4e-20 72.1 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EFA85156.1 - 8e-05 23.3 2.4 9.6e-05 23.0 0.3 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EFA85156.1 - 0.00056 18.9 0.5 0.0011 18.0 0.3 1.3 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFA85156.1 - 0.0017 18.3 0.1 0.056 13.4 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFA85156.1 - 0.0033 16.5 0.0 0.008 15.3 0.0 1.6 1 0 0 1 1 1 1 Seadornavirus VP7 DUF3987 PF13148.6 EFA85156.1 - 0.011 14.8 0.7 0.072 12.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Kinase-like PF14531.6 EFA85156.1 - 0.017 14.5 0.1 0.32 10.3 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EFA85156.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-B_dimeris PF09026.10 EFA85156.1 - 0.045 14.1 5.9 0.099 13.0 5.9 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PKI PF02827.16 EFA85156.1 - 0.65 10.2 5.1 1.6 9.0 0.4 2.5 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor Glyco_transf_10 PF00852.19 EFA85157.1 - 3.2e-34 118.2 0.0 9.4e-34 116.7 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_trans_1_2 PF13524.6 EFA85157.1 - 0.0025 18.2 0.0 0.0054 17.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 TIG PF01833.24 EFA85158.1 - 2.8e-12 46.5 27.4 0.00013 21.9 1.7 4.9 4 0 0 4 4 4 3 IPT/TIG domain SKG6 PF08693.10 EFA85158.1 - 0.0058 16.0 0.4 0.011 15.1 0.4 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Syndecan PF01034.20 EFA85158.1 - 0.2 11.6 0.2 0.36 10.8 0.2 1.4 1 0 0 1 1 1 0 Syndecan domain EGF_2 PF07974.13 EFA85158.1 - 3.1 8.2 7.8 8.1 6.9 7.8 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFA85158.1 - 4.9 7.3 10.1 15 5.8 10.1 1.8 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 EFA85159.1 - 0.0034 17.7 11.4 0.0081 16.5 11.4 1.7 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFA85159.1 - 0.63 10.4 13.4 0.093 13.1 9.2 1.8 2 0 0 2 2 2 0 EGF-like domain Cullin_binding PF03556.15 EFA85160.1 - 4.9e-27 94.8 0.7 7.6e-27 94.1 0.7 1.3 1 0 0 1 1 1 1 Cullin binding Spc7 PF08317.11 EFA85161.1 - 0.0078 15.1 30.1 0.21 10.5 3.7 2.9 1 1 3 4 4 4 4 Spc7 kinetochore protein TSC22 PF01166.18 EFA85161.1 - 0.013 15.8 10.1 0.34 11.2 0.9 3.9 3 1 1 4 4 4 0 TSC-22/dip/bun family ATG16 PF08614.11 EFA85161.1 - 0.018 15.3 12.7 0.018 15.3 12.7 4.4 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) IFT57 PF10498.9 EFA85161.1 - 0.03 13.3 24.4 0.02 13.9 17.1 2.4 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 WEMBL PF05701.11 EFA85161.1 - 0.12 11.1 24.2 0.2 10.3 24.0 1.4 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Baculo_PEP_C PF04513.12 EFA85161.1 - 0.13 12.3 13.6 0.4 10.7 0.1 3.4 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 EFA85161.1 - 0.15 9.6 24.1 0.26 8.8 24.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ApoO PF09769.9 EFA85161.1 - 0.17 11.9 5.2 0.19 11.7 0.8 2.8 3 1 0 3 3 2 0 Apolipoprotein O Golgin_A5 PF09787.9 EFA85161.1 - 0.24 10.8 29.5 0.12 11.9 19.7 2.6 1 1 1 2 2 2 0 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 EFA85161.1 - 0.26 11.3 34.5 0.048 13.7 19.1 2.8 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EFA85161.1 - 0.26 11.8 35.8 2.6 8.6 27.4 3.3 1 1 1 2 2 2 0 Apg6 coiled-coil region NPV_P10 PF05531.12 EFA85161.1 - 0.33 11.4 10.4 1.5 9.3 0.1 3.8 2 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 EFA85161.1 - 0.34 10.9 19.6 0.42 10.6 6.1 3.4 2 1 1 3 3 3 0 Laminin Domain II FUSC PF04632.12 EFA85161.1 - 0.42 9.1 3.5 0.56 8.7 3.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family CdvA PF18822.1 EFA85161.1 - 0.47 10.3 18.9 1.8 8.4 2.2 3.8 2 1 1 3 3 3 0 CdvA-like coiled-coil domain HAUS-augmin3 PF14932.6 EFA85161.1 - 0.48 10.0 22.7 0.13 11.8 6.3 2.8 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 OmpH PF03938.14 EFA85161.1 - 0.53 10.6 29.0 0.21 11.9 9.7 3.3 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 EFA85161.1 - 0.82 9.7 31.1 3.6 7.7 15.0 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus BLOC1_2 PF10046.9 EFA85161.1 - 0.83 10.0 22.0 1.2 9.5 5.9 4.0 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FapA PF03961.13 EFA85161.1 - 1.1 7.8 22.5 0.055 12.1 9.5 2.3 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF3053 PF11254.8 EFA85161.1 - 1.3 8.6 8.0 0.58 9.7 4.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3053) Cep57_CLD_2 PF14197.6 EFA85161.1 - 1.3 9.1 30.6 0.54 10.4 4.0 4.1 1 1 3 4 4 4 0 Centrosome localisation domain of PPC89 DUF4407 PF14362.6 EFA85161.1 - 1.8 7.8 20.7 0.18 11.1 9.4 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) DLP_helical PF18709.1 EFA85161.1 - 2.5 7.2 15.8 1 8.5 5.6 2.8 1 1 1 2 2 2 0 Dynamin-like helical domain DUF948 PF06103.11 EFA85161.1 - 2.8 8.2 4.3 20 5.5 1.1 3.3 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) ERM PF00769.19 EFA85161.1 - 4.6 7.0 34.3 5.8 6.7 24.6 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 EFA85161.1 - 6.1 6.9 16.9 8.3 6.5 3.2 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 EFA85161.1 - 6.5 6.5 28.2 0.11 12.3 9.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF2203 PF09969.9 EFA85161.1 - 6.9 7.4 18.2 21 5.8 2.3 3.7 1 1 3 4 4 4 0 Uncharacterized conserved protein (DUF2203) V_ATPase_I PF01496.19 EFA85161.1 - 7.4 4.4 16.4 11 3.8 16.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lebercilin PF15619.6 EFA85161.1 - 8.1 6.1 30.0 3.9 7.1 20.7 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SRP_SPB PF02978.19 EFA85162.1 - 7.8e-09 36.1 0.1 1.7e-08 35.0 0.1 1.7 1 0 0 1 1 1 1 Signal peptide binding domain DUF2718 PF10918.8 EFA85162.1 - 0.48 10.9 4.6 0.25 11.8 2.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2718) DUF908 PF06012.12 EFA85163.1 - 0.014 14.8 17.2 0.023 14.1 17.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) G-alpha PF00503.20 EFA85164.1 - 7.9e-119 396.9 5.0 9.1e-119 396.7 5.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA85164.1 - 7.2e-13 48.4 0.4 7.1e-09 35.4 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA85164.1 - 0.0015 18.0 1.6 0.4 10.0 0.2 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA85164.1 - 0.0038 17.4 0.2 4.5 7.5 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Tipalpha PF16753.5 EFA85164.1 - 0.039 13.8 0.5 0.098 12.5 0.1 1.8 2 0 0 2 2 2 0 TNF-alpha-Inducing protein of Helicobacter Malic_M PF03949.15 EFA85164.1 - 0.17 11.1 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain CBS PF00571.28 EFA85165.1 - 4e-16 59.2 1.3 0.00013 22.3 0.0 3.8 4 0 0 4 4 4 3 CBS domain DUF2645 PF10840.8 EFA85165.1 - 0.0075 16.9 0.1 0.019 15.6 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2645) Usp PF00582.26 EFA85166.1 - 0.046 14.2 0.5 0.57 10.7 0.1 2.5 2 1 0 2 2 2 0 Universal stress protein family Endotoxin_M PF00555.19 EFA85166.1 - 0.31 11.1 11.7 0.43 10.6 9.0 2.0 2 0 0 2 2 2 0 delta endotoxin UCH PF00443.29 EFA85169.1 - 7.7e-59 199.3 1.3 7.7e-59 199.3 1.3 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFA85169.1 - 3.3e-15 56.5 0.2 3.3e-15 56.5 0.2 3.5 4 0 0 4 4 4 1 DUSP domain Ubiquitin_3 PF14836.6 EFA85169.1 - 6.3e-09 35.7 0.0 2.8e-08 33.7 0.0 2.2 1 0 0 1 1 1 1 Ubiquitin-like domain PhzC-PhzF PF02567.16 EFA85170.1 - 6.7e-39 134.0 0.0 1.5e-38 132.9 0.0 1.6 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein HhH-GPD PF00730.25 EFA85170.1 - 6.5e-14 52.3 0.0 2.1e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 EFA85170.1 - 2.6e-13 49.9 0.0 6.5e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain Whib PF02467.16 EFA85170.1 - 0.18 12.4 2.0 0.32 11.6 0.4 2.2 2 0 0 2 2 2 0 Transcription factor WhiB DUF3439 PF11921.8 EFA85170.1 - 9.2 6.3 10.8 25 4.9 4.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) ketoacyl-synt PF00109.26 EFA85171.1 - 2.5e-69 233.7 0.0 4.8e-69 232.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA85171.1 - 1.5e-47 162.6 0.0 2.3e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA85171.1 - 1.1e-35 122.1 0.0 2.1e-35 121.3 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA85171.1 - 1.9e-35 122.4 0.0 4.4e-35 121.2 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EFA85171.1 - 1.1e-27 97.1 0.0 2.1e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA85171.1 - 1.6e-17 64.0 0.2 4.2e-17 62.6 0.2 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA85171.1 - 6.3e-16 58.9 0.0 2.3e-15 57.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA85171.1 - 5.9e-12 45.4 0.0 4.6e-10 39.3 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EFA85171.1 - 8e-11 43.1 0.0 2.3e-10 41.7 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFA85171.1 - 2.4e-09 37.1 0.0 5.2e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_25 PF13649.6 EFA85171.1 - 1.6e-06 28.7 0.0 3e-05 24.7 0.0 3.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA85171.1 - 1.1e-05 25.4 0.0 2.7e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA85171.1 - 1.3e-05 25.8 0.0 8.5e-05 23.1 0.0 2.5 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA85171.1 - 3.3e-05 23.7 0.0 0.00059 19.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.9 EFA85171.1 - 4.4e-05 23.3 0.0 0.00012 21.8 0.0 1.7 1 0 0 1 1 1 1 Lysine methyltransferase ADH_N PF08240.12 EFA85171.1 - 0.00012 21.9 0.0 0.00044 20.1 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EFA85171.1 - 0.00051 19.5 0.0 0.0018 17.7 0.0 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain Sacchrp_dh_NADP PF03435.18 EFA85171.1 - 0.02 15.2 0.0 0.061 13.6 0.0 1.9 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PP-binding PF00550.25 EFA85171.1 - 0.022 15.1 0.0 0.07 13.5 0.0 1.9 1 0 0 1 1 1 0 Phosphopantetheine attachment site RasGEF PF00617.19 EFA85172.1 - 5.3e-53 179.8 3.1 9.7e-53 179.0 0.3 2.4 2 0 0 2 2 2 1 RasGEF domain Drf_GBD PF06371.13 EFA85172.1 - 1.1e-12 47.9 4.2 6.1e-12 45.5 4.2 2.2 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain RasGEF_N PF00618.20 EFA85172.1 - 2.5e-12 47.0 4.4 3.6e-12 46.4 0.1 3.6 3 0 0 3 3 3 1 RasGEF N-terminal motif Drf_FH3 PF06367.16 EFA85172.1 - 5.9e-09 35.8 0.0 1.9e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 Diaphanous FH3 Domain FERM_f0 PF16511.5 EFA85172.1 - 8.5e-05 22.8 0.4 0.035 14.4 0.0 3.6 3 0 0 3 3 3 1 N-terminal or F0 domain of Talin-head FERM DUF2738 PF10927.8 EFA85173.1 - 0.09 11.8 0.1 0.1 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) ABC2_membrane PF01061.24 EFA85174.1 - 2.5e-35 121.8 20.6 2.5e-35 121.8 20.6 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EFA85174.1 - 2.5e-25 89.6 0.0 3.8e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFA85174.1 - 1.1e-05 25.4 0.0 0.028 14.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA85174.1 - 0.0001 22.0 0.2 0.00024 20.8 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA85174.1 - 0.00022 21.6 0.1 0.00055 20.4 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFA85174.1 - 0.0003 20.8 1.1 0.0095 15.9 0.1 2.4 2 1 1 3 3 2 1 RsgA GTPase AAA_25 PF13481.6 EFA85174.1 - 0.00071 19.2 0.1 0.0014 18.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFA85174.1 - 0.00084 19.9 0.0 0.0015 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EFA85174.1 - 0.008 15.6 0.0 0.17 11.3 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EFA85174.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 EFA85174.1 - 0.026 14.8 0.1 0.065 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFA85174.1 - 0.03 14.5 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EFA85174.1 - 0.05 13.3 0.1 0.097 12.4 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_28 PF13521.6 EFA85174.1 - 0.056 13.7 0.0 0.09 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFA85174.1 - 0.086 12.8 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 NACHT domain PDR_CDR PF06422.12 EFA85174.1 - 0.087 12.7 0.1 0.087 12.7 0.1 2.4 3 0 0 3 3 2 0 CDR ABC transporter AAA_23 PF13476.6 EFA85174.1 - 0.098 13.1 0.2 0.3 11.6 0.0 1.7 1 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFA85174.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 EFA85174.1 - 0.16 11.4 0.2 0.49 9.8 0.1 1.7 2 0 0 2 2 2 0 recA bacterial DNA recombination protein PDR_assoc PF08370.11 EFA85174.1 - 2.4 8.0 6.2 0.64 9.8 0.1 3.0 2 1 1 3 3 3 0 Plant PDR ABC transporter associated TrbC PF04956.13 EFA85174.1 - 7.7 6.8 13.7 0.075 13.3 0.8 2.8 2 1 1 3 3 2 0 TrbC/VIRB2 family Secretin_N_2 PF07655.13 EFA85175.1 - 0.3 11.6 12.8 0.55 10.8 0.7 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain SMN PF06003.12 EFA85176.1 - 1e-09 38.1 27.5 4.5e-08 32.7 11.6 2.9 1 1 1 2 2 2 2 Survival motor neuron protein (SMN) SOBP PF15279.6 EFA85176.1 - 0.044 14.4 22.7 0.054 14.1 22.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 EFA85176.1 - 0.68 8.6 15.8 0.73 8.4 15.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAC1F_C PF16885.5 EFA85176.1 - 3.7 7.1 18.0 4.8 6.7 18.0 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SBE2 PF17076.5 EFA85176.1 - 5.2 5.2 29.8 6.2 4.9 29.8 1.0 1 0 0 1 1 1 0 SBE2, cell-wall formation PI3K_1B_p101 PF10486.9 EFA85176.1 - 6.8 4.3 17.9 8.5 4.0 17.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Ribosomal_S13 PF00416.22 EFA85177.1 - 1.4e-52 177.4 4.8 1.6e-52 177.2 4.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EFA85177.1 - 0.0075 15.1 0.0 0.0082 15.0 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 EFA85177.1 - 0.025 14.8 0.3 0.083 13.2 0.1 1.9 2 1 0 2 2 2 0 Helix-hairpin-helix motif PP28 PF10252.9 EFA85177.1 - 0.38 11.2 3.0 0.4 11.2 1.3 1.8 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 LBP_BPI_CETP_C PF02886.17 EFA85178.1 - 1.5e-06 27.8 0.4 3e-06 26.9 0.4 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EFA85178.1 - 0.0013 18.4 0.5 0.011 15.4 0.1 2.2 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain SecY PF00344.20 EFA85179.1 - 1.8e-75 254.1 12.2 2.3e-75 253.7 12.2 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EFA85179.1 - 1e-17 63.7 0.8 2.8e-17 62.3 0.1 2.2 2 0 0 2 2 2 1 Plug domain of Sec61p DPBB_1 PF03330.18 EFA85180.1 - 7.4e-10 39.0 2.4 6.1e-09 36.0 0.1 3.2 3 1 0 3 3 3 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 EFA85180.1 - 1.8e-06 27.9 0.4 3.1e-06 27.1 0.4 1.4 1 0 0 1 1 1 1 Pollen allergen Barwin PF00967.17 EFA85180.1 - 0.0053 16.6 0.0 0.0093 15.8 0.0 1.5 1 0 0 1 1 1 1 Barwin family SpdB PF05122.13 EFA85180.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Mobile element transfer protein EXOSC1 PF10447.9 EFA85181.1 - 1.5e-12 48.1 3.7 2.4e-11 44.2 0.3 3.4 3 1 1 4 4 4 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EFA85181.1 - 2.8e-12 46.2 0.0 6.1e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region Complex1_LYR PF05347.15 EFA85182.1 - 8.8e-08 32.1 0.7 1.4e-07 31.5 0.7 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) CshA_NR2 PF18651.1 EFA85183.1 - 0.037 13.2 5.9 0.081 12.1 5.9 1.5 1 0 0 1 1 1 0 Surface adhesin CshA non-repetitive domain 2 DUF2704 PF10866.8 EFA85185.1 - 0.2 11.5 5.0 0.3 10.9 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2704) Ras PF00071.22 EFA85186.1 - 3.4e-57 192.6 0.4 5.3e-57 192.0 0.4 1.2 1 0 0 1 1 1 1 Ras family WD-3 PF09765.9 EFA85186.1 - 1.8e-48 165.4 0.3 6.7e-36 124.1 0.1 2.1 1 1 1 2 2 2 2 WD-repeat region Roc PF08477.13 EFA85186.1 - 3.1e-35 121.0 0.2 5.6e-35 120.2 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FANCL_C PF11793.8 EFA85186.1 - 3.7e-16 59.1 1.8 7.1e-16 58.2 1.8 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain Arf PF00025.21 EFA85186.1 - 2.4e-13 49.9 0.3 3.5e-13 49.4 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFA85186.1 - 8.1e-05 22.1 0.1 0.00014 21.3 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFA85186.1 - 0.00017 21.2 0.1 0.00059 19.4 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain zf-RING_2 PF13639.6 EFA85186.1 - 0.00017 21.8 2.4 0.00046 20.5 2.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-HC5HC2H PF13771.6 EFA85186.1 - 0.0012 19.1 0.3 0.0026 18.0 0.3 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain Gtr1_RagA PF04670.12 EFA85186.1 - 0.0013 18.1 0.2 0.0022 17.4 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA85186.1 - 0.0013 18.8 0.1 0.0024 17.9 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA85186.1 - 0.0053 16.7 0.0 0.49 10.3 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase zf-HC5HC2H_2 PF13832.6 EFA85186.1 - 0.0076 16.4 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain RINGv PF12906.7 EFA85186.1 - 0.021 14.9 2.3 0.055 13.6 2.3 1.7 1 0 0 1 1 1 0 RING-variant domain zf-rbx1 PF12678.7 EFA85186.1 - 0.037 14.3 2.3 0.11 12.8 2.3 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFA85186.1 - 0.1 12.7 0.2 0.26 11.3 0.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger EGF_2 PF07974.13 EFA85189.1 - 0.025 15.0 13.6 0.049 14.0 13.6 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA85190.1 - 0.0041 17.5 12.2 0.0083 16.5 12.2 1.5 1 0 0 1 1 1 1 EGF-like domain Imm48 PF15574.6 EFA85190.1 - 0.14 12.0 1.3 1.7 8.5 0.2 2.6 2 0 0 2 2 2 0 Immunity protein 48 EGF_Tenascin PF18720.1 EFA85190.1 - 0.83 9.8 4.3 2.6 8.2 4.3 1.8 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 EFA85190.1 - 4.5 7.7 11.8 8.7 6.7 11.8 1.5 1 0 0 1 1 1 0 EGF-like domain Ac110_PIF PF07280.11 EFA85191.1 - 0.0091 15.8 0.5 0.027 14.2 0.5 1.8 1 0 0 1 1 1 1 Per os infectivity factor AC110 EGF_2 PF07974.13 EFA85191.1 - 0.011 16.1 12.4 0.02 15.3 12.4 1.4 1 0 0 1 1 1 0 EGF-like domain Mon1 PF03164.14 EFA85192.1 - 5e-111 371.6 9.1 1e-103 347.6 5.8 2.0 1 1 1 2 2 2 2 Trafficking protein Mon1 MID_MedPIWI PF18296.1 EFA85194.1 - 0.068 13.0 0.1 0.078 12.8 0.1 1.1 1 0 0 1 1 1 0 MID domain of medPIWI MuF_C PF18819.1 EFA85194.1 - 0.071 13.1 0.5 0.23 11.5 0.1 2.0 2 0 0 2 2 2 0 Phage MuF-C-terminal domain MoaC PF01967.21 EFA85195.1 - 3.6e-48 163.1 2.1 7.3e-48 162.1 1.7 1.8 2 0 0 2 2 2 1 MoaC family Mob_synth_C PF06463.13 EFA85195.1 - 8.9e-40 135.6 0.0 1.9e-39 134.5 0.0 1.6 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EFA85195.1 - 1.2e-30 107.1 0.1 3.9e-30 105.4 0.1 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EFA85195.1 - 1.6e-08 34.9 0.0 4.8e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EFA85195.1 - 5.7e-07 29.7 0.2 2.7e-05 24.3 0.0 3.5 2 1 1 3 3 3 1 4Fe-4S single cluster domain DegQ PF08181.11 EFA85195.1 - 0.086 12.9 1.5 0.19 11.8 0.6 2.1 2 0 0 2 2 2 0 DegQ (SacQ) family Glycophorin_A PF01102.18 EFA85196.1 - 7 6.9 5.5 7.3 6.9 0.0 2.4 2 0 0 2 2 2 0 Glycophorin A Surfac_D-trimer PF09006.11 EFA85197.1 - 0.03 14.2 0.2 0.049 13.5 0.2 1.5 1 1 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation SNF2_N PF00176.23 EFA85198.1 - 3.8e-69 233.1 0.1 8.1e-69 232.0 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA85198.1 - 5.3e-22 78.3 0.0 8.7e-21 74.4 0.0 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNARE_assoc PF09335.11 EFA85199.1 - 8.9e-24 84.3 5.2 8.9e-24 84.3 5.2 2.0 1 1 1 2 2 2 1 SNARE associated Golgi protein MHC_II_beta PF00969.19 EFA85199.1 - 0.13 12.3 0.1 0.32 11.1 0.1 1.6 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain Zn_ribbon_17 PF17120.5 EFA85200.1 - 1.9e-10 40.2 13.7 5.1e-10 38.8 13.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 EFA85200.1 - 1.8e-07 31.4 8.6 1.8e-07 31.4 8.6 3.3 1 1 1 2 2 2 1 Zinc-ribbon like family WD40 PF00400.32 EFA85200.1 - 5.6e-07 30.2 19.1 0.00035 21.3 0.1 7.2 6 0 0 6 6 6 3 WD domain, G-beta repeat SNF2_N PF00176.23 EFA85201.1 - 3.7e-66 223.2 0.2 1e-65 221.8 0.2 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA85201.1 - 1.7e-20 73.4 0.0 2.9e-19 69.4 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EFA85201.1 - 2.5e-12 46.9 0.5 2.5e-12 46.9 0.5 5.9 5 2 0 5 5 5 1 HSA Myb_DNA-bind_6 PF13921.6 EFA85201.1 - 8.8e-07 29.1 0.0 5e-06 26.7 0.0 2.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFA85201.1 - 8.4e-06 25.9 0.0 8.4e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain AdoMetDC_leader PF08132.11 EFA85201.1 - 0.042 13.8 0.2 0.17 11.8 0.2 2.0 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide Rab5ip PF07019.12 EFA85202.1 - 1.1e-11 45.2 3.3 1.3e-11 44.9 3.3 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF4044 PF13253.6 EFA85202.1 - 0.83 9.2 2.4 1.3 8.6 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) Skp1 PF01466.19 EFA85203.1 - 3e-23 81.7 2.0 3.5e-23 81.5 0.6 1.8 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EFA85203.1 - 9.6e-23 80.1 0.1 2.1e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain p450 PF00067.22 EFA85204.1 - 7.9e-99 331.5 0.0 9.3e-99 331.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glucosamine_iso PF01182.20 EFA85205.1 - 7.3e-42 143.8 0.0 9.5e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Pkinase PF00069.25 EFA85206.1 - 1e-18 67.7 3.4 3.7e-16 59.3 3.4 2.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85206.1 - 6.2e-12 45.3 0.0 1.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFA85206.1 - 0.0013 18.1 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1084 PF06454.11 EFA85206.1 - 0.0089 15.4 0.8 0.0089 15.4 0.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1084) APH PF01636.23 EFA85206.1 - 0.25 11.2 0.0 1.8 8.4 0.0 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3430 PF11912.8 EFA85207.1 - 8.9e-23 81.4 27.7 1.1e-22 81.1 27.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) Abhydrolase_3 PF07859.13 EFA85208.1 - 1.2e-13 51.4 0.0 1.8e-13 50.8 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFA85208.1 - 5.5e-12 45.3 0.0 1.3e-11 44.1 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EFA85208.1 - 4.4e-09 36.1 0.1 1.6e-08 34.3 0.1 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EFA85208.1 - 2.5e-06 26.6 0.0 3.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Say1_Mug180 PF10340.9 EFA85208.1 - 3.6e-05 22.8 0.0 5.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_2 PF02230.16 EFA85208.1 - 3.7e-05 23.6 0.0 0.097 12.5 0.0 3.1 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.13 EFA85208.1 - 0.00017 20.2 0.1 0.0014 17.3 0.0 2.1 1 1 1 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_1 PF00561.20 EFA85208.1 - 0.00036 20.3 1.8 0.001 18.8 0.2 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA85208.1 - 0.0036 16.6 0.1 1.4 8.2 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 BAAT_C PF08840.11 EFA85208.1 - 0.014 15.3 0.0 0.03 14.3 0.0 1.6 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 EFA85208.1 - 0.018 15.6 0.0 0.022 15.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Imm74 PF15603.6 EFA85208.1 - 0.039 14.1 0.4 0.082 13.1 0.4 1.5 1 0 0 1 1 1 0 Immunity protein 74 SapB_1 PF05184.15 EFA85209.1 - 6.9e-22 77.1 17.9 4.5e-13 48.9 0.2 3.8 5 0 0 5 5 5 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA85209.1 - 5.4e-17 61.6 12.9 2.6e-11 43.4 2.4 4.0 3 1 0 3 3 3 2 Saposin-like type B, region 2 FAM117 PF15388.6 EFA85209.1 - 0.00046 19.7 2.0 0.0006 19.3 2.0 1.3 1 0 0 1 1 1 1 Protein Family FAM117 Tctex-1 PF03645.13 EFA85209.1 - 0.086 13.1 0.7 0.48 10.7 0.7 2.2 1 1 0 1 1 1 0 Tctex-1 family RAP1 PF07218.11 EFA85209.1 - 4.8 5.3 14.7 6.9 4.8 14.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1667 PF07892.11 EFA85210.1 - 0.014 15.4 0.8 0.13 12.4 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1667) Mucin PF01456.17 EFA85210.1 - 6.1 6.8 18.8 0.11 12.5 8.0 2.7 3 0 0 3 3 3 0 Mucin-like glycoprotein Pox_Ag35 PF03286.14 EFA85210.1 - 6.3 6.5 25.1 3.4 7.4 8.6 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF155 PF02582.14 EFA85211.1 - 1.5e-45 155.4 1.1 2.4e-45 154.8 1.1 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 PRP38 PF03371.15 EFA85212.1 - 2.3e-42 144.8 0.2 3.3e-42 144.3 0.2 1.2 1 0 0 1 1 1 1 PRP38 family HABP4_PAI-RBP1 PF04774.15 EFA85213.1 - 8.3e-17 62.1 6.0 8.3e-17 62.1 6.0 3.4 3 0 0 3 3 3 1 Hyaluronan / mRNA binding family Stm1_N PF09598.10 EFA85213.1 - 1.7e-05 25.6 9.9 1.7e-05 25.6 9.9 4.6 2 2 1 3 3 3 1 Stm1 Pkinase_Tyr PF07714.17 EFA85214.1 - 5.1e-53 180.0 0.0 8.5e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA85214.1 - 5.5e-48 163.6 0.1 2.6e-47 161.4 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain SH2 PF00017.24 EFA85214.1 - 7e-11 42.1 0.0 2.1e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Cbl_N3 PF02762.14 EFA85214.1 - 1.8e-05 24.5 0.0 6e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.14 EFA85214.1 - 0.00056 20.6 0.0 0.0019 18.9 0.0 1.9 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain IBP39 PF11422.8 EFA85214.1 - 0.0021 17.9 0.3 0.16 11.7 0.0 2.5 2 0 0 2 2 2 1 Initiator binding protein 39 kDa SH2_2 PF14633.6 EFA85214.1 - 0.061 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 SH2 domain APH PF01636.23 EFA85214.1 - 0.079 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family NRN1 PF15056.6 EFA85214.1 - 0.083 13.0 0.2 0.31 11.2 0.2 1.9 2 0 0 2 2 2 0 Neuritin protein family TMF_DNA_bd PF12329.8 EFA85214.1 - 2.5 8.2 6.7 0.52 10.3 1.8 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FERM_f0 PF16511.5 EFA85215.1 - 0.0037 17.5 0.0 0.0042 17.3 0.0 1.1 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM Thr_synth_N PF14821.6 EFA85215.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.3 1 1 0 1 1 1 0 Threonine synthase N terminus Ank_2 PF12796.7 EFA85216.1 - 1.8e-36 124.6 1.4 6.8e-17 61.8 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85216.1 - 2.7e-36 123.5 2.2 3.4e-11 43.5 0.1 4.8 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85216.1 - 2.3e-31 104.3 0.1 0.00011 22.3 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EFA85216.1 - 9.6e-27 92.2 2.2 2.4e-05 24.6 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EFA85216.1 - 3.4e-26 91.0 1.1 2.1e-07 31.1 0.1 5.6 1 1 5 6 6 6 4 Ankyrin repeats (many copies) Ninjurin PF04923.12 EFA85216.1 - 0.048 13.6 1.2 0.08 12.9 0.2 1.8 2 0 0 2 2 2 0 Ninjurin DUF2520 PF10728.9 EFA85216.1 - 0.06 13.1 0.0 1.1 9.1 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2520) SNF2_N PF00176.23 EFA85217.1 - 1.7e-64 217.7 10.9 6.6e-64 215.8 3.4 2.7 2 1 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.10 EFA85217.1 - 1.5e-40 137.8 4.3 1.5e-40 137.8 4.3 4.5 4 1 0 4 4 4 1 SLIDE Helicase_C PF00271.31 EFA85217.1 - 9.4e-21 74.2 0.0 7.4e-19 68.1 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HAND PF09110.11 EFA85217.1 - 1.9e-13 51.1 5.8 1.9e-13 51.1 5.8 6.6 3 2 1 4 4 4 1 HAND DBINO PF13892.6 EFA85217.1 - 4.3e-05 23.9 12.9 4.3e-05 23.9 12.9 5.9 4 1 0 4 4 4 1 DNA-binding domain DEAD PF00270.29 EFA85217.1 - 6.5e-05 22.8 0.0 0.00033 20.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase FoP_duplication PF13865.6 EFA85218.1 - 8.1e-08 32.7 18.1 8.1e-08 32.7 18.1 2.8 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 TRAPP PF04051.16 EFA85219.1 - 3.5e-38 130.6 0.2 1.1e-37 129.0 0.2 1.7 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component Ribosomal_L34 PF00468.17 EFA85220.1 - 2.7e-18 65.7 4.0 5.5e-18 64.7 4.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L34 zf-CSL PF05207.13 EFA85221.1 - 1.4e-19 69.6 2.7 2.4e-19 68.8 2.7 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EFA85221.1 - 5.7e-19 68.0 0.7 8.8e-19 67.4 0.7 1.3 1 0 0 1 1 1 1 DnaJ domain zinc_ribbon_4 PF13717.6 EFA85221.1 - 0.01 15.8 2.0 0.012 15.5 0.7 1.8 2 0 0 2 2 2 1 zinc-ribbon domain BORCS7 PF16088.5 EFA85222.1 - 2e-30 105.1 5.5 2.1e-30 105.0 4.6 1.4 1 1 0 1 1 1 1 BLOC-1-related complex sub-unit 7 DUF948 PF06103.11 EFA85222.1 - 0.037 14.3 2.8 0.28 11.5 2.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PH_18 PF18469.1 EFA85222.1 - 0.045 13.7 2.3 0.058 13.4 2.3 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain ENT PF03735.14 EFA85222.1 - 0.057 13.5 0.2 0.12 12.4 0.2 1.6 1 1 0 1 1 1 0 ENT domain CLU PF13236.6 EFA85223.1 - 1.1e-81 273.9 0.0 3.1e-81 272.4 0.0 1.8 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA85223.1 - 1.1e-38 133.1 0.3 1.1e-38 133.1 0.3 4.5 4 1 0 4 4 4 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EFA85223.1 - 1e-32 112.2 6.1 4.8e-11 42.8 0.1 4.4 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFA85223.1 - 6.7e-26 89.4 0.1 2.2e-06 27.3 0.0 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat CLU_N PF15044.6 EFA85223.1 - 7.7e-18 64.6 0.4 5e-17 62.0 0.1 2.6 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_8 PF13181.6 EFA85223.1 - 1.5e-05 24.8 12.6 0.25 11.7 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85223.1 - 2.9e-05 23.9 8.6 1 9.6 0.1 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA85223.1 - 9.8e-05 22.0 11.0 4 7.4 0.2 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFA85223.1 - 0.00094 19.1 1.8 7 6.9 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat DDHD PF02862.17 EFA85223.1 - 0.053 13.7 11.7 0.8 9.8 0.3 3.3 3 0 0 3 3 3 0 DDHD domain UDPGP PF01704.18 EFA85224.1 - 2.6e-47 161.4 0.0 3.8e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF1827 PF08860.10 EFA85224.1 - 0.0035 17.5 0.8 0.018 15.3 0.8 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1827) RabGAP-TBC PF00566.18 EFA85225.1 - 3.2e-51 174.0 0.3 3.2e-51 174.0 0.3 2.9 2 1 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 EFA85225.1 - 8.6e-24 83.6 10.0 4.8e-14 52.2 6.0 2.7 2 0 0 2 2 2 2 GRAM domain EF-hand_1 PF00036.32 EFA85225.1 - 9e-06 24.9 11.2 0.0015 17.9 0.8 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EFA85225.1 - 1.7e-05 24.4 7.1 0.0076 16.1 0.8 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EFA85225.1 - 3.2e-05 24.3 12.4 0.00014 22.2 5.2 2.8 2 1 1 3 3 3 2 EF-hand domain pair Suv3_N PF18114.1 EFA85225.1 - 0.4 10.8 3.0 0.67 10.1 0.4 2.4 2 0 0 2 2 2 0 Suv3 helical N-terminal domain EF-hand_8 PF13833.6 EFA85225.1 - 0.66 9.9 7.2 1.6 8.6 4.4 2.7 1 1 1 2 2 2 0 EF-hand domain pair EB PF01683.18 EFA85226.1 - 0.0041 17.4 4.3 0.013 15.7 4.3 1.9 1 0 0 1 1 1 1 EB module TIG PF01833.24 EFA85226.1 - 0.013 15.6 3.2 0.013 15.6 3.2 4.2 3 1 0 3 3 3 0 IPT/TIG domain EGF_2 PF07974.13 EFA85226.1 - 0.018 15.4 15.8 0.018 15.4 15.8 2.2 2 0 0 2 2 2 0 EGF-like domain IL23 PF16649.5 EFA85226.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Interleukin 23 subunit alpha EGF_Tenascin PF18720.1 EFA85226.1 - 0.22 11.6 9.3 0.54 10.4 9.3 1.7 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 EFA85226.1 - 0.23 12.2 9.3 0.89 10.3 9.3 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF Vps36-NZF-N PF16988.5 EFA85226.1 - 0.63 9.5 5.3 0.18 11.2 0.3 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain EGF PF00008.27 EFA85226.1 - 0.78 10.1 10.5 2.1 8.7 10.5 1.8 1 0 0 1 1 1 0 EGF-like domain Iso_dh PF00180.20 EFA85228.1 - 1.7e-74 251.1 0.0 2.1e-74 250.8 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DLH PF01738.18 EFA85229.1 - 0.001 18.7 0.0 0.0012 18.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFA85229.1 - 0.0028 17.0 0.0 0.18 11.0 0.0 2.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 EFA85229.1 - 0.029 14.3 0.0 6.7 6.6 0.0 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Orn_Arg_deC_N PF02784.16 EFA85230.1 - 6.6e-80 268.0 0.0 8.6e-80 267.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFA85230.1 - 2.6e-18 66.0 0.0 4.3e-18 65.3 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EFA85230.1 - 0.0016 18.0 0.0 0.003 17.0 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Folliculin_C PF16692.5 EFA85231.1 - 6.4e-28 98.0 0.0 1.8e-27 96.5 0.0 1.7 1 0 0 1 1 1 1 Folliculin C-terminal domain Macoilin PF09726.9 EFA85231.1 - 3.9 5.9 11.6 5.1 5.5 11.6 1.1 1 0 0 1 1 1 0 Macoilin family Ran_BP1 PF00638.18 EFA85232.1 - 1.6e-43 147.8 0.7 2.4e-43 147.3 0.7 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EFA85232.1 - 0.0044 16.9 1.1 0.17 11.8 0.1 2.1 2 0 0 2 2 2 2 WH1 domain FAS_N PF17828.1 EFA85232.1 - 0.22 11.5 1.1 0.54 10.3 0.2 2.1 2 1 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta SH3_9 PF14604.6 EFA85233.1 - 2.2e-17 62.6 0.2 4.6e-17 61.6 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 EFA85233.1 - 4.4e-14 52.5 2.9 5.5e-14 52.2 0.0 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EFA85233.1 - 6.8e-14 51.2 0.1 1.3e-13 50.3 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFA85233.1 - 1.1e-13 50.6 0.0 2.3e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain HR1 PF02185.16 EFA85233.1 - 0.00091 19.3 7.8 0.00091 19.3 7.8 3.1 3 1 0 3 3 3 1 Hr1 repeat GAS PF13851.6 EFA85233.1 - 0.0047 16.3 1.1 0.0047 16.3 1.1 2.9 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding DUF4226 PF10774.9 EFA85233.1 - 1.2 9.4 11.8 0.043 14.1 3.2 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4226) Spc7 PF08317.11 EFA85233.1 - 2.8 6.7 30.8 0.22 10.4 13.5 2.8 2 1 0 2 2 2 0 Spc7 kinetochore protein WDCP PF15390.6 EFA85233.1 - 6.2 5.1 17.2 0.51 8.6 11.4 1.8 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family LRR_6 PF13516.6 EFA85234.1 - 4.1e-18 63.8 17.4 2.7e-07 30.1 0.6 5.4 5 0 0 5 5 5 5 Leucine Rich repeat LRR_4 PF12799.7 EFA85234.1 - 3.6e-07 30.4 17.2 0.0083 16.5 6.6 4.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA85234.1 - 0.0019 17.9 21.2 0.63 9.9 7.1 5.1 2 1 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 EFA85234.1 - 0.0035 17.7 13.4 8.9 7.3 0.3 5.4 4 3 1 5 5 5 3 Leucine Rich Repeat WD40 PF00400.32 EFA85235.1 - 6.4e-36 121.7 17.7 0.00016 22.4 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85235.1 - 4.7e-10 39.6 1.8 0.13 12.5 0.0 4.6 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA85235.1 - 2.7e-05 24.2 0.2 0.58 10.2 0.1 4.0 3 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region tRNA_lig_CPD PF08302.11 EFA85235.1 - 0.093 12.2 3.4 0.15 11.5 3.4 1.3 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain HARP PF07443.13 EFA85235.1 - 0.11 12.1 0.2 17 5.2 0.0 2.6 2 0 0 2 2 2 0 HepA-related protein (HARP) DUF1451 PF07295.11 EFA85235.1 - 0.2 11.7 1.0 0.33 11.0 1.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Anoctamin PF04547.12 EFA85236.1 - 5.6e-19 68.3 22.9 2.2e-18 66.3 22.9 1.8 1 1 0 1 1 1 1 Calcium-activated chloride channel TMC PF07810.13 EFA85236.1 - 2.2e-09 37.8 0.2 2.2e-09 37.8 0.2 2.7 3 0 0 3 3 3 1 TMC domain DUF1218 PF06749.12 EFA85236.1 - 0.19 12.3 3.6 3.1 8.4 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) RSN1_7TM PF02714.15 EFA85236.1 - 0.91 8.8 25.9 0.02 14.2 14.7 2.9 2 2 0 2 2 2 0 Calcium-dependent channel, 7TM region, putative phosphate VPS9 PF02204.18 EFA85237.1 - 3.2e-28 98.0 0.4 3.2e-28 98.0 0.4 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Dicty_CTDC PF00526.18 EFA85237.1 - 1.5e-07 31.2 43.7 2.9e-06 27.0 5.6 15.6 13 2 0 14 14 14 9 Dictyostelium (slime mold) repeat PA14 PF07691.12 EFA85237.1 - 2.4e-06 27.4 0.0 2.4e-06 27.4 0.0 3.5 4 1 0 4 4 4 1 PA14 domain GLTT PF01744.20 EFA85237.1 - 0.031 14.0 0.5 0.063 13.0 0.5 1.5 1 0 0 1 1 1 0 GLTT repeat (6 copies) DUF5601 PF18151.1 EFA85237.1 - 0.28 11.5 3.8 0.32 11.3 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5601) LETM1 PF07766.13 EFA85238.1 - 2e-87 293.0 8.5 2e-87 293.0 8.5 2.1 2 0 0 2 2 2 1 LETM1-like protein TAFII55_N PF04658.13 EFA85239.1 - 3.1e-34 118.0 0.4 3.1e-34 118.0 0.4 3.2 3 0 0 3 3 3 1 TAFII55 protein conserved region SUIM_assoc PF16619.5 EFA85239.1 - 0.0038 17.3 18.6 0.017 15.2 0.0 5.1 4 2 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 DUF2408 PF10303.9 EFA85239.1 - 0.021 15.4 0.2 0.021 15.4 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) NPV_P10 PF05531.12 EFA85239.1 - 0.076 13.5 5.1 0.23 11.9 5.1 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Amidinotransf PF02274.17 EFA85240.1 - 4.3e-56 190.5 1.3 2.9e-54 184.5 1.3 2.0 1 1 0 1 1 1 1 Amidinotransferase Stonin2_N PF12016.8 EFA85241.1 - 0.85 9.0 17.7 1.6 8.1 17.7 1.4 1 0 0 1 1 1 0 Stonin 2 PP2C PF00481.21 EFA85242.1 - 1.4e-53 182.1 0.0 3.3e-53 181.0 0.0 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_6 PF13516.6 EFA85242.1 - 0.002 18.1 4.0 0.058 13.5 0.0 3.5 3 0 0 3 3 3 1 Leucine Rich repeat PP2C_2 PF13672.6 EFA85242.1 - 0.0041 16.8 0.0 0.011 15.4 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C DPBB_1 PF03330.18 EFA85242.1 - 0.017 15.4 0.0 0.069 13.4 0.0 2.0 2 0 0 2 2 2 0 Lytic transglycolase SpoU_sub_bind PF08032.12 EFA85242.1 - 0.019 15.2 0.0 0.049 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding Adeno_E3 PF06040.11 EFA85242.1 - 0.11 12.6 6.8 0.063 13.4 3.5 2.2 2 0 0 2 2 2 0 Adenovirus E3 protein PI3_PI4_kinase PF00454.27 EFA85243.1 - 1.7e-40 139.4 0.6 1.7e-37 129.6 0.6 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFA85243.1 - 2.3e-24 85.8 0.4 1.1e-23 83.6 0.1 2.3 2 1 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Epsilon_antitox PF08998.11 EFA85244.1 - 0.047 14.0 4.2 0.49 10.7 0.3 2.9 2 0 0 2 2 2 0 Bacterial epsilon antitoxin F-box-like PF12937.7 EFA85244.1 - 0.15 12.0 3.5 0.62 10.0 3.5 2.0 1 1 0 1 1 1 0 F-box-like Cytokin_check_N PF10407.9 EFA85245.1 - 0.0045 16.9 0.4 0.27 11.2 0.0 3.4 3 1 0 3 3 3 1 Cdc14 phosphatase binding protein N-terminus IP_trans PF02121.18 EFA85246.1 - 6.6e-90 301.0 4.3 1.4e-75 254.0 0.0 2.0 1 1 1 2 2 2 2 Phosphatidylinositol transfer protein MiaE PF06175.11 EFA85248.1 - 0.99 8.9 5.0 0.17 11.4 0.3 2.1 3 0 0 3 3 3 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) NAD_binding_1 PF00175.21 EFA85250.1 - 1.4e-13 51.5 0.0 2.7e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 EFA85250.1 - 1.1e-11 45.3 0.0 2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Globin FAD_binding_6 PF00970.24 EFA85250.1 - 1.7e-09 37.9 0.0 2.8e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFA85250.1 - 2.4e-05 24.5 0.0 0.027 14.6 0.0 3.0 2 1 1 3 3 3 2 Ferric reductase NAD binding domain Protoglobin PF11563.8 EFA85250.1 - 0.009 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Protoglobin Ank_2 PF12796.7 EFA85252.1 - 2.5e-77 255.5 22.7 7.1e-14 52.2 0.3 7.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85252.1 - 3.5e-71 234.7 4.1 1.4e-13 51.1 0.0 11.0 5 2 6 11 11 11 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85252.1 - 2.1e-65 208.9 1.1 1e-05 25.5 0.0 13.4 13 0 0 13 13 13 11 Ankyrin repeat Ank PF00023.30 EFA85252.1 - 3.4e-59 194.9 11.7 1.9e-07 31.2 0.0 13.2 13 0 0 13 13 13 10 Ankyrin repeat Ank_5 PF13857.6 EFA85252.1 - 3.6e-49 164.2 11.3 3.4e-06 27.2 0.3 10.3 3 1 9 12 12 12 11 Ankyrin repeats (many copies) CH PF00307.31 EFA85252.1 - 7.3e-14 51.9 0.2 1.7e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain SOG2 PF10428.9 EFA85252.1 - 0.019 14.2 24.5 0.03 13.5 24.5 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Pkinase PF00069.25 EFA85253.1 - 3.4e-60 203.7 0.2 4.7e-60 203.2 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85253.1 - 1.6e-27 96.4 0.0 3.2e-27 95.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA85253.1 - 6.7e-06 25.6 0.0 1.6e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFA85253.1 - 0.00071 19.0 0.1 0.0013 18.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFA85253.1 - 0.001 17.9 0.1 0.001 17.9 0.1 2.1 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFA85253.1 - 0.013 15.4 0.0 0.033 14.1 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFA85253.1 - 0.032 13.8 0.5 0.032 13.8 0.5 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Velvet PF11754.8 EFA85253.1 - 0.059 13.3 7.2 0.11 12.4 3.5 2.2 2 0 0 2 2 2 0 Velvet factor DUF2340 PF10209.9 EFA85253.1 - 0.079 13.4 1.8 1.1 9.7 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2340) Coilin_N PF15862.5 EFA85255.1 - 2.8e-05 23.9 4.3 2.8e-05 23.9 4.3 9.2 7 2 1 8 8 8 1 Coilin N-terminus TIG PF01833.24 EFA85256.1 - 5.2e-14 52.1 34.0 6.5e-05 22.9 4.2 6.2 5 1 1 6 6 6 5 IPT/TIG domain MspA PF09203.11 EFA85256.1 - 0.15 11.9 2.6 0.44 10.4 2.5 1.9 1 1 0 1 1 1 0 MspA TMEM154 PF15102.6 EFA85256.1 - 3.2 7.6 8.9 0.72 9.8 0.0 3.2 2 1 1 3 3 3 0 TMEM154 protein family TIG PF01833.24 EFA85258.1 - 0.054 13.6 0.1 0.054 13.6 0.1 8.2 7 2 2 9 9 9 0 IPT/TIG domain EGF_2 PF07974.13 EFA85258.1 - 0.12 12.8 17.8 0.26 11.7 17.8 1.6 1 0 0 1 1 1 0 EGF-like domain Pex19 PF04614.12 EFA85261.1 - 0.0015 18.4 0.0 0.0036 17.1 0.0 1.5 1 0 0 1 1 1 1 Pex19 protein family DUF2538 PF10804.8 EFA85261.1 - 0.059 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) zf-UBR PF02207.20 EFA85262.1 - 2.6e-14 53.1 14.1 2.6e-14 53.1 14.1 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Vac14_Fab1_bd PF12755.7 EFA85262.1 - 0.015 15.8 0.1 0.058 14.0 0.1 2.0 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region DNA_pol_B_palm PF14792.6 EFA85262.1 - 0.11 12.7 0.1 1.1 9.5 0.0 2.7 2 0 0 2 2 2 0 DNA polymerase beta palm DUF5356 PF17309.2 EFA85264.1 - 0.028 14.4 0.3 0.028 14.4 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5356) ATG27 PF09451.10 EFA85265.1 - 2.9e-10 40.5 8.7 5.4e-05 23.2 2.3 2.5 1 1 1 2 2 2 2 Autophagy-related protein 27 FNIP PF05725.12 EFA85267.1 - 1.6e-06 28.2 4.4 3.8e-05 23.7 0.0 4.3 4 1 0 4 4 4 1 FNIP Repeat F-box_5 PF18511.1 EFA85267.1 - 3.4e-06 26.5 0.1 7.4e-06 25.4 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA85267.1 - 0.00063 19.6 0.3 0.0015 18.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA85267.1 - 0.084 12.8 0.1 0.3 11.0 0.1 1.9 1 0 0 1 1 1 0 F-box domain ADH_zinc_N PF00107.26 EFA85268.1 - 2.4e-15 56.6 0.1 5.3e-15 55.5 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA85268.1 - 0.00036 20.4 0.0 0.001 18.9 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFA85268.1 - 0.0097 15.2 1.6 0.029 13.7 0.7 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EFA85268.1 - 0.11 13.5 0.0 0.22 12.6 0.0 1.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase zf-UBR PF02207.20 EFA85269.1 - 8.3e-10 38.7 14.3 1.5e-09 37.9 14.3 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF2951 PF11166.8 EFA85269.1 - 3.4 8.0 6.6 9.1 6.6 6.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) FNIP PF05725.12 EFA85270.1 - 1.2e-09 38.1 13.5 0.00082 19.5 0.6 5.5 4 1 0 5 5 5 2 FNIP Repeat F-box_5 PF18511.1 EFA85270.1 - 1.2e-05 24.8 0.2 2.5e-05 23.7 0.2 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA85270.1 - 0.00012 21.9 0.9 0.00036 20.4 0.9 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA85270.1 - 0.096 12.6 1.7 0.32 10.9 1.7 2.0 1 0 0 1 1 1 0 F-box domain Arf PF00025.21 EFA85271.1 - 8.9e-66 220.6 0.1 1e-65 220.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA85271.1 - 1.2e-15 57.8 0.2 1.7e-15 57.3 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA85271.1 - 1.3e-15 57.3 0.0 1.8e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA85271.1 - 6.1e-13 48.7 0.1 7.4e-13 48.4 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFA85271.1 - 9.6e-13 48.0 2.1 9.4e-10 38.2 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFA85271.1 - 3.8e-11 42.8 0.0 4.8e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA85271.1 - 4.3e-05 23.6 0.1 9.4e-05 22.5 0.1 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 EFA85271.1 - 0.00071 19.2 1.1 0.14 11.7 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EFA85271.1 - 0.016 14.8 0.4 0.065 12.9 0.2 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 EFA85271.1 - 0.034 14.7 0.0 0.055 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFA85271.1 - 0.043 14.0 0.3 0.19 11.9 0.1 1.9 1 1 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 EFA85271.1 - 0.047 13.2 0.1 0.11 12.0 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain NACHT PF05729.12 EFA85271.1 - 0.058 13.3 1.0 2.8 7.8 0.1 2.5 3 0 0 3 3 3 0 NACHT domain RsgA_GTPase PF03193.16 EFA85271.1 - 0.083 12.8 0.1 6.5 6.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase NTPase_1 PF03266.15 EFA85271.1 - 0.11 12.4 0.2 0.17 11.8 0.2 1.4 1 1 0 1 1 1 0 NTPase PduV-EutP PF10662.9 EFA85271.1 - 0.21 11.3 0.7 0.55 10.0 0.3 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF5305 PF17231.2 EFA85272.1 - 0.0033 16.8 0.9 0.0033 16.8 0.9 2.6 3 0 0 3 3 3 1 Family of unknown function (DUF5305) EGF_2 PF07974.13 EFA85272.1 - 0.0076 16.6 11.6 0.018 15.4 11.6 1.6 1 0 0 1 1 1 1 EGF-like domain DUF3467 PF11950.8 EFA85273.1 - 0.045 13.9 0.1 0.13 12.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3467) LRR_6 PF13516.6 EFA85274.1 - 0.59 10.3 9.0 4.6 7.5 1.1 3.5 3 0 0 3 3 3 0 Leucine Rich repeat IFT20 PF14931.6 EFA85275.1 - 0.15 12.3 2.6 0.38 10.9 2.6 1.7 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Actin PF00022.19 EFA85276.1 - 6e-140 466.4 0.0 2e-139 464.7 0.0 1.7 1 1 0 1 1 1 1 Actin GCV_H PF01597.19 EFA85277.1 - 2.7e-43 146.8 0.2 3.3e-43 146.5 0.2 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EFA85277.1 - 0.0002 21.1 0.4 0.00035 20.3 0.4 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 EFA85277.1 - 0.0084 16.0 0.3 0.013 15.4 0.3 1.2 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain RVT_1 PF00078.27 EFA85278.1 - 1.3e-41 142.6 0.3 3.2e-41 141.3 0.3 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4326 PF14216.6 EFA85281.1 - 4.6e-24 84.9 1.1 9.7e-24 83.9 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) DUF4634 PF15465.6 EFA85281.1 - 2.5 8.4 5.4 1.1 9.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) DUF3430 PF11912.8 EFA85282.1 - 8.3e-19 68.5 20.6 1.1e-18 68.1 20.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) CLU PF13236.6 EFA85283.1 - 3.1e-61 207.0 0.0 6.9e-61 205.9 0.0 1.6 1 0 0 1 1 1 1 Clustered mitochondria LRR_6 PF13516.6 EFA85283.1 - 2.7e-13 48.8 20.2 0.18 11.9 0.0 11.4 12 0 0 12 12 12 4 Leucine Rich repeat LRR_4 PF12799.7 EFA85283.1 - 3.7e-10 39.9 22.0 0.1 13.0 0.1 8.5 6 1 1 8 8 8 5 Leucine Rich repeats (2 copies) eIF3_p135 PF12807.7 EFA85283.1 - 9.9e-06 25.7 6.7 1e-05 25.6 0.1 4.1 5 0 0 5 5 5 1 Translation initiation factor eIF3 subunit 135 LEAP-2 PF07359.11 EFA85283.1 - 0.1 12.5 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) LRR_1 PF00560.33 EFA85283.1 - 2 9.3 13.7 71 4.6 0.2 7.7 7 0 0 7 7 7 0 Leucine Rich Repeat Kelch_6 PF13964.6 EFA85288.1 - 5.6e-07 29.6 5.0 0.002 18.4 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EFA85288.1 - 0.15 12.1 2.4 22 5.2 0.0 3.9 3 1 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 EFA85288.1 - 0.25 11.4 5.5 5.1 7.2 0.1 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 EFA85288.1 - 7.6 6.2 6.1 8.1 6.1 0.0 3.6 3 1 0 3 3 3 0 Kelch motif SAM_PNT PF02198.16 EFA85289.1 - 0.048 13.6 0.1 0.14 12.1 0.1 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Rootletin PF15035.6 EFA85289.1 - 0.049 13.6 10.5 0.072 13.1 10.5 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF3138 PF11336.8 EFA85289.1 - 0.097 11.3 0.6 0.13 10.9 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Seryl_tRNA_N PF02403.22 EFA85289.1 - 0.29 11.4 7.5 4.3 7.6 0.5 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ALMT PF11744.8 EFA85289.1 - 0.36 9.6 7.7 0.48 9.2 7.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Thioredoxin_2 PF13098.6 EFA85289.1 - 0.8 10.2 3.7 4.4 7.8 3.7 2.2 1 1 0 1 1 1 0 Thioredoxin-like domain CREPT PF16566.5 EFA85289.1 - 2.9 8.0 6.7 14 5.8 0.7 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour OrfB_Zn_ribbon PF07282.11 EFA85291.1 - 0.14 12.1 2.6 0.99 9.4 0.0 3.3 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Ank_5 PF13857.6 EFA85292.1 - 0.014 15.7 0.0 0.57 10.6 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Inj_translocase PF16928.5 EFA85292.1 - 0.084 12.3 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome YpzG PF14139.6 EFA85293.1 - 0.15 12.3 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 YpzG-like protein DUF3447 PF11929.8 EFA85294.1 - 0.002 18.0 5.7 0.2 11.6 1.6 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF3447) Lectin_legB PF00139.19 EFA85296.1 - 1.7e-14 54.0 0.0 2.3e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Legume lectin domain Bact_lectin PF18483.1 EFA85296.1 - 2.7e-13 50.4 0.5 3.8e-13 49.9 0.5 1.2 1 0 0 1 1 1 1 Bacterial lectin Laminin_G_2 PF02210.24 EFA85296.1 - 0.021 15.4 0.4 0.081 13.5 0.0 2.1 2 1 0 2 2 2 0 Laminin G domain Sec62 PF03839.16 EFA85296.1 - 0.061 12.8 0.3 0.092 12.2 0.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 PTPRCAP PF15713.5 EFA85296.1 - 1.9 8.8 9.2 3.2 8.0 9.2 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Auts2 PF15336.6 EFA85296.1 - 3.7 7.6 4.9 5.7 7.0 4.9 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein CDC45 PF02724.14 EFA85296.1 - 7.8 4.7 8.0 11 4.2 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein FNIP PF05725.12 EFA85297.1 - 1.7e-09 37.7 22.2 0.0004 20.5 0.1 6.8 4 2 2 6 6 6 5 FNIP Repeat Alpha_L_fucos PF01120.17 EFA85298.1 - 3.4e-99 332.6 13.7 1.5e-97 327.2 13.7 2.6 1 1 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EFA85298.1 - 2.6e-20 72.8 0.1 5.1e-20 71.8 0.1 1.5 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain PH PF00169.29 EFA85299.1 - 7.1e-10 39.3 0.1 1.4e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA85299.1 - 7e-05 23.2 0.5 0.00026 21.4 0.5 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFA85299.1 - 0.0011 19.2 0.1 2.4 8.5 0.0 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain DUF2277 PF10041.9 EFA85299.1 - 0.15 12.4 0.1 53 4.3 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2277) Rotavirus_VP7 PF05868.11 EFA85300.1 - 0.053 12.9 0.0 0.056 12.8 0.0 1.1 1 0 0 1 1 1 0 Rotavirus major outer capsid protein VP7 EF-hand_1 PF00036.32 EFA85301.1 - 2.3e-12 45.5 0.3 6.9e-05 22.1 0.2 2.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA85301.1 - 3.1e-12 45.4 0.2 1.6e-06 27.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFA85301.1 - 1.5e-09 37.5 0.6 1.4e-07 31.2 0.0 1.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 EFA85301.1 - 8.8e-09 35.7 0.1 1.1e-08 35.4 0.1 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFA85301.1 - 2.5e-06 26.7 0.2 0.00054 19.3 0.1 2.3 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 EFA85301.1 - 0.00096 19.5 0.0 0.0011 19.3 0.0 1.0 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFA85301.1 - 0.0033 17.7 0.0 0.0043 17.4 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain DUF563 PF04577.14 EFA85302.1 - 5.2e-27 95.3 0.0 1.3e-26 94.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Glycos_transf_1 PF00534.20 EFA85302.1 - 3.7e-26 91.7 0.0 6.2e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFA85302.1 - 5.7e-22 78.6 0.1 1.2e-21 77.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_2 PF00535.26 EFA85302.1 - 8.9e-20 71.2 0.0 2e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_4 PF13439.6 EFA85302.1 - 3.7e-09 36.8 0.0 7.9e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_tranf_2_3 PF13641.6 EFA85302.1 - 1.1e-08 35.2 0.0 2.8e-07 30.6 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFA85302.1 - 1.8e-07 30.9 0.0 2e-06 27.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_1_2 PF13524.6 EFA85302.1 - 0.00031 21.1 0.0 0.00095 19.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_2_3 PF13632.6 EFA85302.1 - 0.0012 18.8 0.3 0.0064 16.4 0.3 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_7C PF02709.14 EFA85302.1 - 0.099 12.3 0.6 0.25 11.0 0.6 1.6 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Ank_2 PF12796.7 EFA85303.1 - 6.4e-09 36.3 4.8 0.021 15.4 0.4 6.4 3 1 3 6 6 6 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85303.1 - 1.3e-05 25.6 8.2 0.54 10.9 0.1 7.2 6 3 0 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85303.1 - 1.5e-05 25.0 4.3 34 5.5 0.0 8.4 9 0 0 9 9 9 1 Ankyrin repeat DUF3447 PF11929.8 EFA85303.1 - 0.0043 17.0 2.0 2.1 8.3 0.4 4.0 2 0 0 2 2 2 2 Domain of unknown function (DUF3447) Ank_5 PF13857.6 EFA85303.1 - 0.0054 17.0 0.1 4.7 7.7 0.0 4.5 4 2 1 5 5 5 1 Ankyrin repeats (many copies) MutS_V PF00488.21 EFA85304.1 - 6e-40 137.3 0.2 1.1e-39 136.4 0.2 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFA85304.1 - 6.1e-18 65.7 0.0 1.6e-17 64.4 0.0 1.7 2 0 0 2 2 2 1 MutS domain III DDE_Tnp_4 PF13359.6 EFA85304.1 - 2.8e-17 62.8 0.0 5.5e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.6 EFA85304.1 - 3.5e-07 29.8 0.1 3.4e-05 23.5 0.0 2.8 2 0 0 2 2 2 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA85304.1 - 0.00057 19.6 0.1 0.0011 18.7 0.1 1.4 1 0 0 1 1 1 1 Transposase DDE domain MutS_IV PF05190.18 EFA85304.1 - 0.0096 16.2 0.0 0.032 14.6 0.0 2.0 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 EFA85304.1 - 0.26 11.3 0.0 0.26 11.3 0.0 4.7 5 1 0 5 5 5 0 AAA domain Endonuclease_1 PF04231.13 EFA85305.1 - 0.017 14.8 0.0 0.019 14.7 0.0 1.0 1 0 0 1 1 1 0 Endonuclease I Actin PF00022.19 EFA85306.1 - 1.1e-122 409.6 0.0 8e-122 406.8 0.0 1.9 1 1 0 1 1 1 1 Actin zf-UBR PF02207.20 EFA85307.1 - 2.3e-16 59.7 13.4 2.3e-16 59.7 13.4 2.8 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) zf-C3HC4 PF00097.25 EFA85307.1 - 0.015 15.1 3.3 0.63 10.0 2.1 3.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EFA85307.1 - 0.8 9.6 5.1 0.64 9.9 1.2 2.8 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 EFA85307.1 - 9.3 6.2 11.7 0.57 10.1 3.1 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RasGEF_N_2 PF14663.6 EFA85309.1 - 3.4e-32 111.1 0.0 1.1e-31 109.4 0.0 1.9 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 EFA85309.1 - 6.2e-29 100.0 0.3 1.1e-26 92.8 0.1 2.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.6 EFA85309.1 - 1.9e-05 25.0 0.2 0.19 12.2 0.1 2.4 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.22 EFA85309.1 - 0.012 15.8 1.6 4.1 7.9 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat RICTOR_M PF14666.6 EFA85309.1 - 0.028 14.2 0.2 12 5.7 0.0 3.5 2 1 2 4 4 4 0 Rapamycin-insensitive companion of mTOR, middle domain HEAT_PBS PF03130.16 EFA85309.1 - 0.042 14.5 0.4 0.91 10.4 0.0 3.0 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 EFA85309.1 - 0.094 13.2 0.0 3.1 8.4 0.0 2.9 3 0 0 3 3 3 0 HEAT-like repeat ANAPC_CDC26 PF10471.9 EFA85309.1 - 0.29 12.0 5.8 0.79 10.6 5.8 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 RICTOR_N PF14664.6 EFA85310.1 - 2.6e-109 365.6 3.7 3.3e-109 365.3 3.7 1.1 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RCC1 PF00415.18 EFA85311.1 - 3.6e-60 200.4 14.6 8.1e-10 39.2 0.0 7.2 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA85311.1 - 4.9e-23 80.4 31.7 9.3e-06 25.3 0.0 8.4 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat Exonuc_VII_L PF02601.15 EFA85312.1 - 0.027 14.1 15.0 0.52 9.8 6.5 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit AAA_23 PF13476.6 EFA85312.1 - 0.14 12.7 19.3 1.7 9.1 0.7 2.3 2 0 0 2 2 2 0 AAA domain Stealth_CR2 PF11380.8 EFA85312.1 - 0.24 11.6 2.3 2.2 8.5 0.5 2.4 2 0 0 2 2 2 0 Stealth protein CR2, conserved region 2 Pkinase_fungal PF17667.1 EFA85312.1 - 4.9 5.8 9.9 2.4 6.9 1.3 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF4094 PF13334.6 EFA85312.1 - 7.9 7.0 14.0 2.5 8.6 2.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Ank_2 PF12796.7 EFA85314.1 - 1.6e-15 57.4 1.4 0.0023 18.5 0.0 5.6 4 2 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85314.1 - 2.4e-08 34.4 8.0 0.084 13.5 0.1 8.0 6 3 1 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85314.1 - 1.2e-06 28.4 8.1 1.2 9.9 0.0 10.4 11 2 2 13 13 13 1 Ankyrin repeat Ank_5 PF13857.6 EFA85314.1 - 4e-05 23.8 0.5 36 4.9 0.0 7.4 9 0 0 9 9 9 0 Ankyrin repeats (many copies) YtfJ_HI0045 PF09695.10 EFA85314.1 - 0.0085 15.7 0.1 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (YtfJ_HI0045) PTRF_SDPR PF15237.6 EFA85314.1 - 0.058 13.0 0.8 0.092 12.3 0.8 1.2 1 0 0 1 1 1 0 PTRF/SDPR family UAA PF08449.11 EFA85315.1 - 3.4e-64 216.9 21.8 4.2e-64 216.6 21.8 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFA85315.1 - 5e-10 39.7 25.2 9.5e-07 29.1 12.3 2.8 2 1 1 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EFA85315.1 - 7.6e-05 22.4 11.4 7.6e-05 22.4 11.4 2.1 1 1 0 2 2 2 1 Solute carrier family 35 TPT PF03151.16 EFA85315.1 - 0.054 12.8 15.0 0.61 9.4 2.5 2.4 2 1 0 2 2 2 0 Triose-phosphate Transporter family DUF4130 PF13566.6 EFA85315.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 Orf78 PF06024.12 EFA85315.1 - 6.6 7.1 7.8 0.24 11.7 0.8 2.2 3 0 0 3 3 3 0 Orf78 (ac78) Chordopox_A13L PF05961.11 EFA85315.1 - 8.9 6.6 8.3 0.3 11.3 0.8 2.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein p450 PF00067.22 EFA85316.1 - 3e-94 316.4 0.0 3.4e-94 316.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Vps16_C PF04840.12 EFA85317.1 - 1.3e-77 261.0 8.3 1.7e-77 260.6 8.3 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 EFA85317.1 - 1.6e-62 211.6 0.3 1.4e-40 139.3 0.0 2.1 2 0 0 2 2 2 2 Vps16, N-terminal region LRR_6 PF13516.6 EFA85318.1 - 5.4e-21 72.8 53.1 0.036 14.1 0.0 12.3 12 0 0 12 12 12 9 Leucine Rich repeat LRR_1 PF00560.33 EFA85318.1 - 5e-06 26.3 34.6 3.7 8.5 0.3 10.4 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_4 PF12799.7 EFA85318.1 - 0.0063 16.9 63.4 0.63 10.5 10.0 9.5 5 3 7 12 12 12 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA85318.1 - 0.13 12.1 48.7 0.36 10.6 4.0 8.9 6 2 1 8 8 8 0 Leucine rich repeat DUF3808 PF10300.9 EFA85319.1 - 4.8e-33 114.6 11.2 1.7e-32 112.8 11.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EFA85319.1 - 3.9e-06 26.6 9.1 0.31 11.3 0.2 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA85319.1 - 0.00024 21.5 7.2 1.1 10.1 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA85319.1 - 0.0015 19.1 2.9 0.012 16.2 0.0 3.7 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA85319.1 - 0.0099 16.4 2.4 16 6.1 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA85319.1 - 0.17 11.7 8.8 13 5.8 0.2 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA85319.1 - 0.26 11.6 6.3 3.7 7.9 0.1 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFA85319.1 - 1.9 8.1 11.8 0.26 11.0 0.1 3.6 3 2 1 4 4 4 0 Tetratricopeptide repeat-like domain Acetyltransf_4 PF13420.7 EFA85320.1 - 7.4e-19 68.4 1.9 8.7e-19 68.2 1.9 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA85320.1 - 4.7e-13 49.4 0.5 6e-13 49.1 0.5 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA85320.1 - 6e-07 29.8 0.5 9.1e-07 29.2 0.5 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA85320.1 - 9.3e-07 29.6 0.0 1.1e-06 29.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFA85320.1 - 7.6e-05 22.7 0.1 0.0001 22.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFA85320.1 - 0.0011 19.0 0.1 0.0031 17.6 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA85320.1 - 0.0089 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein TIG PF01833.24 EFA85321.1 - 6e-82 269.8 144.1 1.9e-12 47.1 3.1 17.1 16 2 1 17 17 17 12 IPT/TIG domain FPL PF09758.9 EFA85321.1 - 7.5 6.5 11.2 0.39 10.7 3.1 2.8 2 0 0 2 2 2 0 Uncharacterised conserved protein DNase_II PF03265.15 EFA85322.1 - 3.8e-28 98.7 7.9 3.7e-16 59.3 3.1 3.3 3 0 0 3 3 3 2 Deoxyribonuclease II TIG PF01833.24 EFA85322.1 - 5.5e-17 61.6 55.0 1.4e-07 31.5 1.6 10.3 10 0 0 10 10 10 4 IPT/TIG domain SdrD_B PF17210.3 EFA85322.1 - 2.9e-05 24.2 0.3 0.00015 21.9 0.2 2.4 2 0 0 2 2 2 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA85322.1 - 0.043 14.1 0.1 0.57 10.5 0.0 2.8 3 0 0 3 3 3 0 Carboxypeptidase regulatory-like domain Spore-coat_CotD PF11122.8 EFA85322.1 - 2.7 8.8 5.4 0.96 10.3 0.8 2.8 2 0 0 2 2 2 0 Inner spore coat protein D FNIP PF05725.12 EFA85324.1 - 6.1e-14 51.9 20.4 7.5e-07 29.2 1.1 5.3 4 1 1 5 5 5 4 FNIP Repeat DUF835 PF05763.12 EFA85324.1 - 0.0095 15.7 0.3 1.4 8.7 0.1 3.5 3 1 1 4 4 4 1 Protein of unknown function (DUF835) ELO PF01151.18 EFA85325.1 - 2.4e-64 217.3 17.1 2.8e-64 217.1 17.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CIAPIN1 PF05093.13 EFA85326.1 - 1.6e-20 73.5 13.8 4.6e-19 68.8 13.6 2.4 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF2520 PF10728.9 EFA85326.1 - 0.059 13.1 0.1 0.084 12.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) ELO PF01151.18 EFA85327.1 - 7.4e-29 101.0 10.6 8.8e-29 100.8 10.6 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family zf-C2H2_9 PF16293.5 EFA85328.1 - 0.53 10.2 7.2 0.54 10.1 0.9 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Na_Ca_ex PF01699.24 EFA85329.1 - 1.2e-18 67.5 34.5 2.6e-12 46.9 19.3 3.9 3 1 0 3 3 3 2 Sodium/calcium exchanger protein YccF PF03733.13 EFA85329.1 - 6.5e-11 42.8 12.1 6.5e-11 42.8 12.1 4.8 4 0 0 4 4 4 1 Inner membrane component domain PMM PF03332.13 EFA85330.1 - 1.1e-101 339.2 1.2 1.2e-101 339.1 1.2 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EFA85330.1 - 8e-07 29.1 0.0 3.1e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EFA85330.1 - 0.0056 16.2 0.0 0.45 10.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EFA85330.1 - 0.14 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase LRR_4 PF12799.7 EFA85331.1 - 0.0021 18.4 2.2 5.7 7.5 0.0 4.2 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) CBM49 PF09478.10 EFA85332.1 - 6.3e-16 58.5 4.8 1.5e-15 57.2 4.8 1.6 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 EFA85332.1 - 0.0088 16.3 3.4 0.022 15.1 3.4 1.7 1 0 0 1 1 1 1 Cellulose binding domain TRAP_alpha PF03896.16 EFA85332.1 - 0.023 13.9 1.8 1.6 7.9 0.1 2.1 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Arf PF00025.21 EFA85333.1 - 5.1e-19 68.4 0.1 1.3e-18 67.0 0.1 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA85333.1 - 0.016 15.3 0.0 0.032 14.3 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 EFA85333.1 - 0.098 12.1 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF1899 PF08953.11 EFA85334.1 - 3.9e-32 109.9 0.3 1e-31 108.6 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EFA85334.1 - 4.2e-19 68.2 0.1 7.4e-19 67.4 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EFA85334.1 - 1.3e-15 57.5 0.3 0.00055 20.7 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85334.1 - 4e-06 27.0 0.2 0.023 15.0 0.0 4.0 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA85334.1 - 0.0011 18.0 0.0 0.19 10.6 0.0 3.1 1 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ATP-synt_G PF04718.15 EFA85335.1 - 3.8e-05 24.4 0.1 4.2e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit WH2 PF02205.20 EFA85336.1 - 1.1e-05 25.0 2.0 2.2e-05 24.1 2.0 1.5 1 0 0 1 1 1 1 WH2 motif Pkinase_Tyr PF07714.17 EFA85336.1 - 0.00015 21.1 0.6 0.0008 18.8 0.0 2.3 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.25 EFA85336.1 - 0.00054 19.4 0.7 0.0045 16.4 0.3 2.3 1 1 0 1 1 1 1 Protein kinase domain Totivirus_coat PF05518.11 EFA85336.1 - 3.4 5.6 8.6 5.1 5.0 8.6 1.2 1 0 0 1 1 1 0 Totivirus coat protein Anti-TRAP PF15777.5 EFA85337.1 - 1.8 8.5 13.9 35 4.5 11.7 2.8 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 EFA85337.1 - 7.3 6.9 17.4 5 7.4 0.9 4.3 3 1 1 4 4 4 0 Family of unknown function (DUF5351) MFS_1 PF07690.16 EFA85338.1 - 9e-62 209.0 46.1 5.4e-52 176.9 23.7 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA85338.1 - 8.9e-14 51.2 1.5 8.9e-14 51.2 1.5 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EFA85338.1 - 3e-08 33.4 3.7 3e-08 33.4 3.7 2.3 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB LacY_symp PF01306.19 EFA85338.1 - 3.6e-05 22.7 1.9 3.6e-05 22.7 1.9 3.7 2 2 0 4 4 4 2 LacY proton/sugar symporter OATP PF03137.20 EFA85338.1 - 0.012 13.9 12.2 0.19 10.0 3.6 3.4 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family PTR2 PF00854.21 EFA85338.1 - 1.1 8.0 13.9 1.2 7.9 1.2 3.4 3 0 0 3 3 3 0 POT family MFS_3 PF05977.13 EFA85338.1 - 8.3 4.7 17.3 0.96 7.8 5.9 3.5 3 2 1 4 4 4 0 Transmembrane secretion effector Ctr PF04145.15 EFA85339.1 - 2.9e-26 92.9 7.1 1.2e-25 90.9 7.1 1.9 1 1 0 1 1 1 1 Ctr copper transporter family Cyt-b5 PF00173.28 EFA85340.1 - 3.6e-23 81.5 0.0 8.7e-23 80.3 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF3275 PF11679.8 EFA85340.1 - 0.065 13.2 0.1 0.55 10.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) TMEM154 PF15102.6 EFA85340.1 - 0.36 10.7 4.6 0.58 10.1 4.6 1.2 1 0 0 1 1 1 0 TMEM154 protein family FDF PF09532.10 EFA85340.1 - 1.1 10.1 4.9 4.1 8.3 2.9 2.1 2 0 0 2 2 2 0 FDF domain EXS PF03124.14 EFA85341.1 - 2.4e-87 293.4 34.6 3.8e-87 292.7 34.6 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EFA85341.1 - 1.1e-33 117.8 29.3 3e-32 113.0 29.3 2.3 1 1 0 1 1 1 1 SPX domain RCC1 PF00415.18 EFA85342.1 - 8.9e-25 87.1 10.3 5.7e-09 36.5 0.0 5.5 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 EFA85342.1 - 5.9e-22 78.1 0.6 8.4e-05 23.1 0.0 6.4 4 2 0 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA85342.1 - 5.7e-14 50.9 0.1 3.9 8.3 0.0 9.2 8 1 1 9 9 9 2 Ankyrin repeat Ank_4 PF13637.6 EFA85342.1 - 1.7e-13 50.8 2.7 0.38 11.4 0.0 9.1 5 3 3 8 8 8 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85342.1 - 3.7e-13 49.4 1.2 3.6 8.0 0.0 8.3 6 3 2 8 8 8 4 Ankyrin repeats (many copies) RCC1_2 PF13540.6 EFA85342.1 - 4.4e-08 32.7 16.6 0.15 11.9 0.6 6.5 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat TIR_2 PF13676.6 EFA85342.1 - 0.0019 18.8 0.2 0.062 13.9 0.1 3.1 2 1 0 2 2 2 1 TIR domain DUF3447 PF11929.8 EFA85342.1 - 0.019 14.9 0.1 1.5 8.8 0.0 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3447) Ank PF00023.30 EFA85342.1 - 0.035 14.5 0.0 11 6.7 0.0 4.7 6 0 0 6 6 6 0 Ankyrin repeat DUF249 PF03158.13 EFA85342.1 - 0.064 13.0 5.6 0.12 12.1 0.1 3.5 4 1 1 5 5 5 0 Multigene family 530 protein Pet191_N PF10203.9 EFA85343.1 - 0.01 16.1 1.5 0.01 16.1 1.5 1.7 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Tetraspanin PF00335.20 EFA85344.1 - 0.016 14.9 1.6 0.025 14.3 1.6 1.3 1 0 0 1 1 1 0 Tetraspanin family GWT1 PF06423.12 EFA85344.1 - 0.25 11.4 1.9 0.37 10.9 1.9 1.4 1 1 0 1 1 1 0 GWT1 FPP PF05911.11 EFA85345.1 - 0.0013 17.0 22.9 0.0013 17.0 22.9 2.5 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil Lebercilin PF15619.6 EFA85345.1 - 0.0052 16.5 23.5 0.0052 16.5 23.5 3.2 2 1 1 3 3 3 2 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 EFA85345.1 - 0.012 15.8 16.9 0.012 15.8 16.9 4.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 EFA85345.1 - 0.12 12.4 53.9 1.9 8.5 20.2 4.7 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rab5-bind PF09311.11 EFA85345.1 - 2.2 7.6 49.2 0.014 14.8 16.0 3.7 1 1 2 3 3 3 0 Rabaptin-like protein HrpB7 PF09486.10 EFA85345.1 - 2.2 8.7 10.9 1.1 9.6 0.9 3.7 2 2 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) HALZ PF02183.18 EFA85345.1 - 3.1 8.1 27.8 1.9 8.7 1.9 5.7 4 1 1 5 5 5 0 Homeobox associated leucine zipper Golgin_A5 PF09787.9 EFA85345.1 - 5.3 6.4 58.5 11 5.4 16.4 3.4 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF4407 PF14362.6 EFA85345.1 - 5.6 6.2 37.0 1.2 8.4 11.8 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2935 PF11155.8 EFA85345.1 - 10 6.5 24.8 0.071 13.4 4.6 4.3 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Glyco_hydro_31 PF01055.26 EFA85346.1 - 1.3e-152 509.1 3.4 1.7e-152 508.7 3.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EFA85346.1 - 1.3e-28 99.5 0.3 3.9e-28 98.0 0.3 1.9 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EFA85346.1 - 7.8e-10 38.9 1.6 2.2e-09 37.5 0.2 2.7 2 0 0 2 2 2 1 Galactose mutarotase-like fn3 PF00041.21 EFA85347.1 - 3.3e-20 72.2 14.8 2.8e-05 24.4 0.2 6.0 5 0 0 5 5 5 4 Fibronectin type III domain DUF2369 PF10179.9 EFA85347.1 - 0.089 13.2 0.0 4.3 7.8 0.0 3.3 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) Syndecan PF01034.20 EFA85347.1 - 0.25 11.3 0.6 0.56 10.2 0.6 1.5 1 0 0 1 1 1 0 Syndecan domain EGF_2 PF07974.13 EFA85347.1 - 0.51 10.7 9.3 1.7 9.1 9.3 1.9 1 0 0 1 1 1 0 EGF-like domain PilA4 PF18682.1 EFA85347.1 - 1.2 9.5 15.2 0.4 11.1 0.9 4.4 3 1 1 4 4 4 0 Pilin A4 V-set_CD47 PF08204.11 EFA85347.1 - 1.7 8.6 7.7 4.9 7.2 0.1 4.1 4 0 0 4 4 4 0 CD47 immunoglobulin-like domain SNF2_N PF00176.23 EFA85348.1 - 4.3e-78 262.5 3.2 1e-77 261.3 3.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.6 EFA85348.1 - 3.9e-08 33.5 7.9 3.9e-08 33.5 7.9 3.3 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFA85348.1 - 7.6e-08 32.1 7.5 7.6e-08 32.1 7.5 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFA85348.1 - 5.8e-07 29.4 7.5 5.8e-07 29.4 7.5 3.0 3 0 0 3 3 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFA85348.1 - 5.8e-07 29.3 8.9 5.8e-07 29.3 8.9 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA85348.1 - 6.1e-07 29.4 5.3 6.1e-07 29.4 5.3 2.7 3 0 0 3 3 1 1 RING-type zinc-finger Helicase_C PF00271.31 EFA85348.1 - 3.2e-06 27.5 1.5 8.7e-06 26.0 0.2 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 EFA85348.1 - 5.6e-05 22.9 5.7 0.00024 20.9 5.7 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFA85348.1 - 8.9e-05 22.3 8.8 8.9e-05 22.3 8.8 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA85348.1 - 0.0017 18.6 5.0 0.0017 18.6 5.0 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFA85348.1 - 0.006 16.7 10.5 0.006 16.7 10.5 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING DUF3439 PF11921.8 EFA85348.1 - 0.0065 16.4 1.1 0.02 14.8 1.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) zf-Nse PF11789.8 EFA85348.1 - 0.025 14.4 7.0 0.071 12.9 7.0 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-CW PF07496.15 EFA85348.1 - 0.59 10.2 11.9 0.045 13.8 5.6 2.6 2 0 0 2 2 2 0 CW-type Zinc Finger zf-RING_6 PF14835.6 EFA85348.1 - 2 8.3 6.3 0.82 9.6 2.4 2.4 3 0 0 3 3 3 0 zf-RING of BARD1-type protein zinc_ribbon_9 PF14369.6 EFA85348.1 - 3 8.2 6.9 3.7 7.9 1.6 3.0 2 0 0 2 2 2 0 zinc-ribbon adh_short PF00106.25 EFA85350.1 - 3.7e-40 137.5 2.4 7.5e-40 136.5 2.4 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA85350.1 - 4.9e-32 111.3 4.1 1.1e-31 110.2 4.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 EFA85350.1 - 2.4e-26 92.2 0.5 5e-26 91.1 0.5 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 EFA85350.1 - 4.6e-18 65.8 1.4 4.6e-18 65.8 1.4 1.8 2 0 0 2 2 2 1 KR domain Alkyl_sulf_C PF14864.6 EFA85350.1 - 6.2e-05 23.3 0.4 0.00011 22.5 0.4 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal DUF3235 PF11574.8 EFA85350.1 - 0.0047 17.8 4.0 0.0047 17.8 4.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3235) RNase_T PF00929.24 EFA85351.1 - 4.7e-08 33.8 1.1 7.7e-08 33.1 0.1 2.0 2 0 0 2 2 2 1 Exonuclease EloA-BP1 PF15870.5 EFA85351.1 - 0.16 12.2 0.0 0.16 12.2 0.0 3.4 3 0 0 3 3 3 0 ElonginA binding-protein 1 Mucin PF01456.17 EFA85351.1 - 6.7 6.7 50.2 0.17 11.9 18.4 2.9 3 0 0 3 3 3 0 Mucin-like glycoprotein DEAD PF00270.29 EFA85353.1 - 2.9e-43 147.7 0.3 1.6e-42 145.2 0.1 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA85353.1 - 2.4e-31 108.4 7.2 2.4e-28 98.7 0.5 3.6 4 0 0 4 4 4 2 Helicase conserved C-terminal domain CBS PF00571.28 EFA85354.1 - 2e-21 76.1 1.7 3.1e-10 40.3 0.7 2.5 2 1 0 2 2 2 2 CBS domain dCache_2 PF08269.11 EFA85354.1 - 0.017 14.3 1.1 0.051 12.7 0.4 1.9 1 1 0 2 2 2 0 Cache domain RhoGEF PF00621.20 EFA85356.1 - 1e-46 159.5 3.4 3.8e-46 157.6 3.4 2.1 1 0 0 1 1 1 1 RhoGEF domain Ion_trans PF00520.31 EFA85356.1 - 1e-05 24.9 14.2 1e-05 24.9 14.2 2.2 3 0 0 3 3 3 1 Ion transport protein PH PF00169.29 EFA85356.1 - 0.00011 22.6 0.0 0.00041 20.8 0.0 2.0 1 0 0 1 1 1 1 PH domain TMCCDC2 PF15844.5 EFA85356.1 - 0.26 11.2 0.0 0.26 11.2 0.0 2.7 3 0 0 3 3 3 0 Transmembrane and coiled-coil domain-containing protein 2 RRM_1 PF00076.22 EFA85357.1 - 1.4e-55 185.0 0.3 1.4e-18 66.4 0.1 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA85357.1 - 1.5e-09 37.5 0.6 0.0048 16.5 0.0 4.0 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EFA85357.1 - 2.4e-08 33.9 0.0 0.29 11.2 0.0 3.7 3 0 0 3 3 3 3 RNA binding domain RRM_3 PF08777.11 EFA85357.1 - 2.6e-05 24.2 0.1 0.0016 18.5 0.0 2.6 1 1 1 2 2 2 1 RNA binding motif BRAP2 PF07576.12 EFA85357.1 - 2.7e-05 24.3 0.0 2 8.7 0.0 3.4 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_7 PF16367.5 EFA85357.1 - 4.9e-05 23.4 0.0 0.68 10.1 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif PHM7_cyt PF14703.6 EFA85357.1 - 0.01 16.1 7.8 0.028 14.6 0.1 4.7 4 3 4 8 8 8 0 Cytosolic domain of 10TM putative phosphate transporter DUF4720 PF15846.5 EFA85357.1 - 0.038 13.8 0.0 4 7.4 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4720) SMN PF06003.12 EFA85357.1 - 0.11 11.7 3.3 0.21 10.8 3.3 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Fzo_mitofusin PF04799.13 EFA85358.1 - 0.013 15.0 10.5 0.013 15.0 10.5 3.1 2 1 1 3 3 3 0 fzo-like conserved region GvpL_GvpF PF06386.11 EFA85358.1 - 0.5 10.2 12.3 0.11 12.4 7.7 2.1 1 1 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF HPS3_N PF14761.6 EFA85359.1 - 0.0051 16.4 2.8 0.0073 15.9 2.8 1.2 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 DJ-1_PfpI PF01965.24 EFA85360.1 - 1.7e-10 41.0 0.1 2.3e-10 40.5 0.1 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family F-box-like PF12937.7 EFA85365.1 - 0.054 13.4 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 F-box-like DUF5305 PF17231.2 EFA85365.1 - 0.092 12.1 0.4 0.13 11.6 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) p450 PF00067.22 EFA85366.1 - 2.1e-68 231.2 0.2 2.3e-68 231.1 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.32 EFA85369.1 - 6.2e-44 147.1 26.8 1.1e-07 32.4 0.1 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EFA85369.1 - 5.6e-14 51.8 0.9 1e-13 50.9 0.9 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EFA85369.1 - 4.3e-11 43.0 5.0 0.00028 21.1 0.1 5.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA85369.1 - 1.8e-09 37.6 0.2 0.25 11.4 0.0 4.6 2 2 2 4 4 4 3 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EFA85369.1 - 2.3e-09 37.0 1.4 0.00042 19.8 0.1 2.5 1 1 1 2 2 2 2 WD40-like domain F-box PF00646.33 EFA85369.1 - 1.2e-07 31.4 2.9 4e-07 29.8 2.9 1.9 1 0 0 1 1 1 1 F-box domain Frtz PF11768.8 EFA85369.1 - 0.00088 17.7 1.1 0.57 8.4 0.0 3.2 1 1 2 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz DUF1474 PF07342.11 EFA85369.1 - 0.32 11.6 2.6 2.1 8.9 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1474) DUF812 PF05667.11 EFA85369.1 - 1.2 7.9 11.0 0.012 14.5 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF812) ABC2_membrane_3 PF12698.7 EFA85369.1 - 1.3 8.1 4.2 0.28 10.3 0.9 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein PIP5K PF01504.18 EFA85370.1 - 1.5e-66 224.4 2.5 1.5e-66 224.4 2.5 3.2 2 2 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase dDENN PF03455.19 EFA85370.1 - 0.083 12.9 0.2 0.25 11.3 0.2 1.9 1 0 0 1 1 1 0 dDENN domain DUF4470 PF14737.6 EFA85371.1 - 4.6e-11 42.8 0.0 2.5e-10 40.4 0.0 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4470) TPR_1 PF00515.28 EFA85371.1 - 4.8e-05 23.0 0.8 0.017 14.9 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85371.1 - 0.0011 18.9 0.3 0.48 10.7 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA85371.1 - 0.0064 16.8 0.0 0.039 14.2 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA85371.1 - 0.021 15.0 0.7 0.24 11.7 0.1 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFA85371.1 - 0.068 13.4 0.2 0.48 10.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA85371.1 - 0.078 12.7 0.3 2.7 7.8 0.1 2.5 2 0 0 2 2 2 0 TPR repeat TPR_19 PF14559.6 EFA85371.1 - 0.096 13.2 0.0 0.41 11.2 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1214 PF06742.11 EFA85375.1 - 0.11 13.0 0.1 0.25 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1214) Ribosomal_S5 PF00333.20 EFA85376.1 - 5.8e-17 61.4 0.6 3e-16 59.2 1.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain DUF916 PF06030.12 EFA85376.1 - 0.4 10.7 2.3 6.7 6.8 0.1 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF916) NosD PF05048.13 EFA85377.1 - 9.2e-05 21.8 12.4 9.2e-05 21.8 12.4 2.2 1 1 1 2 2 2 1 Periplasmic copper-binding protein (NosD) EGF_2 PF07974.13 EFA85377.1 - 0.00057 20.2 1.2 0.002 18.5 1.2 2.0 1 0 0 1 1 1 1 EGF-like domain Chlam_PMP PF02415.17 EFA85377.1 - 0.042 14.3 54.0 0.3 11.7 0.2 9.8 9 0 0 9 9 9 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF4957 PF16318.5 EFA85377.1 - 1.5 8.7 16.4 11 5.9 8.5 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4957) Methyltransf_25 PF13649.6 EFA85378.1 - 0.00021 21.9 0.1 0.0006 20.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.6 EFA85378.1 - 0.033 15.2 0.2 0.1 13.6 0.2 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFA85378.1 - 0.076 13.8 0.0 0.076 13.8 0.0 3.0 3 1 0 3 3 3 0 Methyltransferase domain Reticulon PF02453.17 EFA85379.1 - 2.2e-27 96.0 6.7 2.2e-27 96.0 6.7 1.7 2 0 0 2 2 2 1 Reticulon Apolipoprotein PF01442.18 EFA85379.1 - 0.00075 19.4 0.2 0.0011 18.8 0.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain SF-assemblin PF06705.11 EFA85379.1 - 0.0046 16.3 0.9 0.0093 15.3 0.3 1.8 2 0 0 2 2 2 1 SF-assemblin/beta giardin DUF883 PF05957.13 EFA85379.1 - 0.027 15.1 1.5 0.06 14.0 1.5 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Remorin_C PF03763.13 EFA85379.1 - 0.04 13.8 4.3 0.072 13.0 4.3 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region REF PF05755.12 EFA85379.1 - 0.075 12.8 0.6 0.2 11.4 0.1 1.9 2 0 0 2 2 2 0 Rubber elongation factor protein (REF) DNA_repr_REX1B PF14966.6 EFA85379.1 - 0.094 13.4 1.6 0.17 12.6 0.4 2.1 2 1 0 2 2 2 0 DNA repair REX1-B BcrAD_BadFG PF01869.20 EFA85379.1 - 0.17 11.4 0.9 0.31 10.5 0.9 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family ApoLp-III PF07464.11 EFA85379.1 - 0.45 10.6 8.0 0.45 10.6 6.4 1.8 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) MtrB PF05440.12 EFA85379.1 - 0.74 10.3 3.2 59 4.2 0.7 3.3 3 1 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B ApoC-I PF04691.12 EFA85379.1 - 0.79 9.7 4.9 10 6.1 4.7 2.5 1 1 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) Holin_BhlA PF10960.8 EFA85379.1 - 0.94 9.5 4.3 1.3 9.1 1.9 2.5 2 0 0 2 2 2 0 BhlA holin family DUF1664 PF07889.12 EFA85379.1 - 0.99 9.5 6.7 0.74 9.9 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) YtxH PF12732.7 EFA85379.1 - 1 10.0 10.9 6.4 7.4 10.6 2.4 2 1 0 2 2 1 0 YtxH-like protein RE_MjaI PF09568.10 EFA85379.1 - 1.2 9.0 5.9 0.63 9.8 3.4 1.8 2 0 0 2 2 2 0 MjaI restriction endonuclease G-alpha PF00503.20 EFA85380.1 - 5.3e-96 321.9 3.6 6.3e-96 321.6 2.7 1.6 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA85380.1 - 8.6e-12 44.9 1.7 2e-08 33.9 0.1 3.4 3 1 0 4 4 4 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFA85380.1 - 6e-06 25.8 0.8 0.00075 18.9 0.0 2.5 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFA85380.1 - 0.0012 19.0 0.2 2.6 8.3 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA85380.1 - 0.0061 16.6 0.0 2.9 8.0 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFA85380.1 - 0.029 14.1 0.1 0.07 12.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain GRP PF07172.11 EFA85382.1 - 0.0094 16.6 17.7 0.0094 16.6 17.7 4.0 4 0 0 4 4 4 1 Glycine rich protein family CAP PF00188.26 EFA85384.1 - 3.4e-14 53.8 0.1 4.4e-14 53.4 0.1 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Prothymosin PF03247.14 EFA85385.1 - 0.56 10.7 31.9 0.027 14.9 25.3 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family NOA36 PF06524.12 EFA85385.1 - 1.3 8.3 28.0 3.6 6.8 28.0 1.7 1 0 0 1 1 1 0 NOA36 protein Translin PF01997.16 EFA85386.1 - 6.8e-53 179.7 5.0 1.5e-52 178.6 5.0 1.6 1 0 0 1 1 1 1 Translin family Glyco_hydro_65m PF03632.15 EFA85386.1 - 3.1e-50 171.2 0.0 9.9e-42 143.2 0.1 2.8 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.9 EFA85386.1 - 7.8e-08 31.1 0.0 6.5e-05 21.5 0.1 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2152) T_Ag_DNA_bind PF02217.16 EFA85386.1 - 0.0041 17.7 0.7 0.016 15.8 0.7 2.1 1 0 0 1 1 1 1 Origin of replication binding protein fn3_5 PF06280.12 EFA85386.1 - 0.019 15.6 1.0 2.8 8.7 0.1 2.9 2 0 0 2 2 2 0 Fn3-like domain Pet127 PF08634.10 EFA85387.1 - 5.4e-65 219.6 5.4 5.4e-65 219.6 5.4 2.1 2 0 0 2 2 2 1 Mitochondrial protein Pet127 Menin PF05053.13 EFA85387.1 - 0.13 10.6 6.0 0.2 10.0 6.0 1.2 1 0 0 1 1 1 0 Menin Hydin_ADK PF17213.3 EFA85387.1 - 3.8 7.7 7.3 9.6 6.4 7.3 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 EFA85387.1 - 4.3 6.0 11.1 6.7 5.4 11.1 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFA85387.1 - 5.1 6.2 12.4 7.6 5.6 12.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter COX4 PF02936.14 EFA85388.1 - 0.00092 19.2 0.0 0.0012 18.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV NTP_transferase PF00483.23 EFA85389.1 - 4.8e-28 98.4 0.0 6.4e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EFA85389.1 - 1.7e-06 27.5 1.0 1.7e-06 27.5 1.0 3.6 3 1 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFA85389.1 - 4.9e-06 27.0 0.0 7.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain DMAP_binding PF06464.11 EFA85389.1 - 0.21 12.4 0.0 0.38 11.6 0.0 1.3 1 0 0 1 1 1 0 DMAP1-binding Domain zf-rbx1 PF12678.7 EFA85390.1 - 0.0052 17.0 2.3 0.043 14.1 0.5 3.0 3 0 0 3 3 3 1 RING-H2 zinc finger domain Prok-RING_1 PF14446.6 EFA85390.1 - 0.0092 15.9 2.4 0.026 14.4 2.4 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 WD40_like PF17005.5 EFA85390.1 - 0.042 13.2 0.3 0.82 8.9 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain zf-RING_UBOX PF13445.6 EFA85390.1 - 0.062 13.3 5.2 0.16 12.1 5.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EFA85390.1 - 0.12 12.7 7.7 0.033 14.5 3.5 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 EFA85390.1 - 0.38 10.6 7.0 0.83 9.5 5.2 2.6 2 1 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 EFA85390.1 - 0.78 9.8 3.4 2.3 8.3 3.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFA85390.1 - 2.6 8.0 4.4 5.5 6.9 1.2 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Histone PF00125.24 EFA85391.1 - 1.2e-08 35.4 2.3 0.0008 19.8 0.5 2.4 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFA85391.1 - 5.4e-06 26.6 6.9 0.012 15.9 0.3 2.6 3 0 0 3 3 3 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-18kDa PF02269.16 EFA85391.1 - 0.00046 20.2 0.5 0.21 11.6 0.0 2.8 2 1 1 3 3 3 2 Transcription initiation factor IID, 18kD subunit TFIID-31kDa PF02291.15 EFA85391.1 - 0.0024 17.9 0.1 0.8 9.8 0.0 2.3 2 0 0 2 2 2 2 Transcription initiation factor IID, 31kD subunit Histone_H2A_C PF16211.5 EFA85391.1 - 0.0073 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A TAFII28 PF04719.14 EFA85391.1 - 0.02 15.0 2.4 1.6 8.9 0.1 2.2 2 0 0 2 2 2 0 hTAFII28-like protein conserved region TFIID_20kDa PF03847.13 EFA85391.1 - 0.038 14.5 0.2 0.34 11.4 0.1 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A CENP-T_C PF15511.6 EFA85391.1 - 0.11 12.6 0.8 7.6 6.7 0.0 2.3 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold PBP1_TM PF14812.6 EFA85391.1 - 0.21 12.0 9.8 0.11 12.9 6.1 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TAF PF02969.17 EFA85391.1 - 0.38 10.9 3.6 1.7 8.9 0.4 2.6 3 0 0 3 3 3 0 TATA box binding protein associated factor (TAF) TLD PF07534.16 EFA85392.1 - 3.8e-24 85.5 1.1 6.6e-24 84.7 1.1 1.4 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFA85392.1 - 5.4e-06 26.7 0.8 8e-06 26.1 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain DUF4337 PF14235.6 EFA85392.1 - 0.23 11.6 1.6 8.4 6.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DUF4795 PF16043.5 EFA85392.1 - 0.47 10.0 5.5 0.63 9.6 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) ELO PF01151.18 EFA85393.1 - 1.4e-26 93.6 1.6 2e-26 93.1 1.6 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Proton_antipo_N PF00662.20 EFA85393.1 - 0.069 13.2 0.1 0.069 13.2 0.1 2.1 2 1 1 3 3 3 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Vps8 PF12816.7 EFA85394.1 - 4.7e-53 179.7 10.6 6.8e-51 172.6 2.2 4.3 4 0 0 4 4 4 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EFA85394.1 - 4.4e-09 36.3 13.8 8.8e-06 25.7 0.1 4.3 4 0 0 4 4 4 3 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 EFA85394.1 - 0.0025 17.8 5.4 0.0078 16.2 5.4 1.8 1 0 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 EFA85394.1 - 0.0038 17.2 7.1 0.011 15.7 7.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain DUF2250 PF10007.9 EFA85394.1 - 0.033 14.3 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) zf-RING_2 PF13639.6 EFA85394.1 - 0.16 12.4 7.5 0.55 10.6 7.5 2.0 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EFA85394.1 - 0.45 10.4 5.5 1.2 9.1 5.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFA85394.1 - 0.95 9.4 6.0 1.3 9.0 2.1 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EFA85394.1 - 1.4 8.9 4.2 3.7 7.6 4.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.6 EFA85394.1 - 1.5 8.9 5.3 4.3 7.4 5.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EFA85394.1 - 1.6 8.6 7.2 5.1 7.1 7.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA85394.1 - 2.1 8.7 7.0 8.5 6.8 7.0 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain EB PF01683.18 EFA85395.1 - 0.011 16.0 2.5 0.027 14.8 2.5 1.6 1 0 0 1 1 1 0 EB module EGF_2 PF07974.13 EFA85395.1 - 0.014 15.8 16.8 0.028 14.8 16.8 1.5 1 0 0 1 1 1 0 EGF-like domain LRR_4 PF12799.7 EFA85395.1 - 0.079 13.4 5.8 0.66 10.5 4.5 3.1 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA85395.1 - 0.53 10.1 5.5 0.74 9.6 3.6 2.3 2 0 0 2 2 2 0 Leucine rich repeat TIG PF01833.24 EFA85396.1 - 0.0022 18.1 1.1 0.0022 18.1 1.1 3.8 4 0 0 4 4 4 1 IPT/TIG domain TRIQK PF15168.6 EFA85398.1 - 0.15 12.0 1.2 0.56 10.1 1.2 2.0 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family Ras PF00071.22 EFA85399.1 - 1.1e-53 181.2 0.3 1.3e-53 180.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA85399.1 - 2.1e-20 73.1 0.2 4.5e-20 72.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA85399.1 - 4.1e-10 39.4 0.2 5.2e-10 39.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA85399.1 - 0.00018 21.5 0.1 0.017 15.1 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA85399.1 - 0.00029 20.9 0.0 0.00055 20.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Hist_deacetyl PF00850.19 EFA85400.1 - 2.1e-82 277.1 0.0 2.7e-82 276.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain CLASP_N PF12348.8 EFA85401.1 - 1.4e-08 34.6 4.5 0.03 13.9 0.1 5.5 3 2 3 6 6 6 2 CLASP N terminal IBN_N PF03810.19 EFA85401.1 - 7.9e-07 28.9 0.6 5.3e-05 23.0 0.2 3.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EFA85401.1 - 1.9e-06 28.4 5.7 0.12 13.0 0.0 5.9 4 2 2 7 7 7 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EFA85401.1 - 9.6e-06 25.7 9.2 0.0023 18.0 0.2 5.1 4 2 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFA85401.1 - 3.3e-05 24.3 2.6 2.7 8.6 0.1 6.8 5 1 0 6 6 6 1 HEAT-like repeat ParcG PF10274.9 EFA85401.1 - 8.4e-05 22.8 0.2 0.67 10.0 0.0 4.4 2 2 2 4 4 4 1 Parkin co-regulated protein HEAT PF02985.22 EFA85401.1 - 0.00015 21.7 19.9 1 9.8 0.1 9.7 11 0 0 11 11 11 1 HEAT repeat RIX1 PF08167.12 EFA85401.1 - 0.0034 17.2 2.4 0.96 9.1 0.0 3.8 4 0 0 4 4 4 2 rRNA processing/ribosome biogenesis UME PF08064.13 EFA85401.1 - 0.0083 16.0 7.5 1.1 9.2 0.0 5.8 6 1 1 7 7 7 1 UME (NUC010) domain RXT2_N PF08595.11 EFA85401.1 - 4.8 7.2 8.7 25 4.9 0.3 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal Tfb4 PF03850.14 EFA85402.1 - 3.3e-56 190.8 1.1 4.3e-56 190.4 1.1 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 DUF3175 PF11373.8 EFA85402.1 - 0.0028 17.8 0.0 0.0057 16.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3175) ACPS PF01648.20 EFA85403.1 - 9e-25 87.0 0.1 1e-24 86.8 0.1 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EFA85403.1 - 0.00041 20.4 0.2 0.54 10.4 0.0 2.4 2 1 0 2 2 2 2 4'-phosphopantetheinyl transferase N-terminal domain Methyltransf_5 PF01795.19 EFA85403.1 - 0.045 13.3 0.1 0.055 13.0 0.1 1.1 1 0 0 1 1 1 0 MraW methylase family DUF5004 PF16395.5 EFA85403.1 - 0.11 12.4 0.1 0.26 11.3 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5004) WD40 PF00400.32 EFA85404.1 - 1.1e-09 38.8 13.9 0.004 18.0 0.2 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Dynein_IC2 PF11540.8 EFA85404.1 - 8.3e-09 35.2 1.7 8.3e-09 35.2 1.7 2.1 2 0 0 2 2 2 1 Cytoplasmic dynein 1 intermediate chain 2 ANAPC4_WD40 PF12894.7 EFA85404.1 - 0.00071 19.8 0.0 0.012 15.9 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Atg14 PF10186.9 EFA85404.1 - 0.87 8.6 8.2 0.17 10.9 0.6 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_L7Ae PF01248.26 EFA85405.1 - 6.8e-22 77.0 0.0 9.1e-22 76.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family WH2 PF02205.20 EFA85406.1 - 2.9e-10 39.6 2.1 5.5e-10 38.7 2.1 1.5 1 0 0 1 1 1 1 WH2 motif DUF5110 PF17137.4 EFA85408.1 - 0.044 14.1 4.4 0.12 12.7 4.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) WEMBL PF05701.11 EFA85408.1 - 0.096 11.4 5.1 0.15 10.8 5.1 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light RRM_1 PF00076.22 EFA85409.1 - 2.5e-43 145.7 0.1 1.9e-18 66.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA85409.1 - 4.8e-08 32.6 0.0 6.6e-06 25.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EFA85409.1 - 0.0024 17.9 0.0 0.89 9.6 0.0 3.2 3 0 0 3 3 3 1 RNA binding domain RRM_3 PF08777.11 EFA85409.1 - 0.034 14.2 0.0 44 4.2 0.0 3.2 3 0 0 3 3 3 0 RNA binding motif RRM_7 PF16367.5 EFA85409.1 - 0.058 13.5 0.8 3.8 7.7 0.0 3.6 4 1 0 4 4 4 0 RNA recognition motif TFIIA PF03153.13 EFA85409.1 - 0.91 9.5 10.3 1.2 9.0 10.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Patched PF02460.18 EFA85411.1 - 2.2e-80 270.9 10.8 6.8e-78 262.6 8.7 2.5 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 EFA85411.1 - 6.7e-49 165.7 8.9 6.7e-49 165.7 8.9 3.3 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation NPC1_N PF16414.5 EFA85411.1 - 8.7e-17 61.5 19.8 5.5e-16 58.9 17.3 2.9 2 1 0 2 2 2 1 Niemann-Pick C1 N terminus ACR_tran PF00873.19 EFA85411.1 - 0.0072 14.0 14.4 0.015 13.0 14.4 1.4 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family ASCH PF04266.14 EFA85412.1 - 3.4e-13 50.1 0.0 3.9e-13 49.9 0.0 1.0 1 0 0 1 1 1 1 ASCH domain PEPCK_N PF17297.2 EFA85412.1 - 0.13 11.8 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain Translin PF01997.16 EFA85413.1 - 2e-50 171.7 3.3 2.6e-50 171.3 3.3 1.2 1 0 0 1 1 1 1 Translin family ADP_PFK_GK PF04587.15 EFA85413.1 - 0.0027 16.4 0.7 0.0039 15.8 0.7 1.2 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region DUF848 PF05852.11 EFA85413.1 - 0.24 11.5 3.5 0.18 11.9 1.0 1.8 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF676 PF05057.14 EFA85414.1 - 7.7e-30 104.0 0.0 8.6e-30 103.9 0.0 1.0 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EFA85414.1 - 1.9e-06 27.8 0.0 2.4e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EFA85414.1 - 0.00014 21.6 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 EFA85414.1 - 0.00025 20.3 0.0 0.00032 20.0 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Palm_thioest PF02089.15 EFA85414.1 - 0.00053 19.9 0.0 0.00059 19.8 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_2 PF01674.18 EFA85414.1 - 0.001 18.7 0.0 0.0013 18.3 0.0 1.3 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_1 PF00561.20 EFA85414.1 - 0.029 14.0 0.0 0.035 13.8 0.0 1.3 1 1 0 1 1 1 0 alpha/beta hydrolase fold p450 PF00067.22 EFA85415.1 - 3.1e-94 316.4 0.2 3.5e-94 316.1 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EFA85416.1 - 1.1e-84 284.9 0.0 1e-60 205.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 TMEM70 PF06979.12 EFA85416.1 - 0.086 13.3 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 Assembly, mitochondrial proton-transport ATP synth complex Myotub-related PF06602.14 EFA85417.1 - 1.6e-124 415.4 0.0 1.6e-124 415.4 0.0 2.5 3 0 0 3 3 3 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EFA85417.1 - 0.0071 16.3 1.3 0.016 15.2 0.0 2.3 3 1 0 3 3 3 1 Tyrosine phosphatase family Ubie_methyltran PF01209.18 EFA85418.1 - 1e-21 77.3 0.1 2.2e-20 73.0 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFA85418.1 - 1.5e-20 73.7 0.1 3.8e-20 72.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA85418.1 - 4.8e-19 68.7 0.0 9.1e-19 67.7 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA85418.1 - 6e-19 68.5 0.0 1.2e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA85418.1 - 1e-11 45.5 0.0 1.7e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA85418.1 - 4.4e-11 42.9 0.0 5.8e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFA85418.1 - 8.2e-07 28.7 0.0 1.9e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EFA85418.1 - 1.5e-06 27.9 0.1 2.6e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EFA85418.1 - 1.9e-06 27.8 0.0 2.9e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 EFA85418.1 - 0.00014 21.6 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_18 PF12847.7 EFA85418.1 - 0.00019 21.4 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 EFA85418.1 - 0.00067 19.0 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase FtsJ PF01728.19 EFA85418.1 - 0.003 17.7 0.1 0.01 16.0 0.1 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Cons_hypoth95 PF03602.15 EFA85418.1 - 0.0043 16.7 0.0 0.0079 15.9 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 EFA85418.1 - 0.0047 16.4 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_8 PF05148.15 EFA85418.1 - 0.0061 16.4 0.1 0.039 13.8 0.1 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase tRNA_U5-meth_tr PF05958.11 EFA85418.1 - 0.0064 15.5 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_32 PF13679.6 EFA85418.1 - 0.0092 16.0 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EFA85418.1 - 0.013 14.5 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CheR PF01739.18 EFA85418.1 - 0.048 13.1 0.0 0.1 12.1 0.0 1.6 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_20 PF12147.8 EFA85418.1 - 0.052 12.7 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DREV PF05219.12 EFA85418.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Imm7 PF15585.6 EFA85418.1 - 0.11 12.8 0.2 3 8.1 0.0 2.7 2 1 1 3 3 3 0 Immunity protein 7 CMAS PF02353.20 EFA85418.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.3 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pex19 PF04614.12 EFA85420.1 - 0.0054 16.5 2.5 0.0054 16.5 2.5 3.0 1 1 1 2 2 2 1 Pex19 protein family DUF3439 PF11921.8 EFA85420.1 - 0.038 14.0 7.0 0.065 13.2 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MIEAP PF16026.5 EFA85420.1 - 1.6 8.9 3.5 3 8.0 1.1 2.2 2 1 0 2 2 2 0 Mitochondria-eating protein HNF-1_N PF04814.13 EFA85420.1 - 1.9 9.1 11.3 0.44 11.1 5.7 2.0 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Mucin PF01456.17 EFA85420.1 - 7.4 6.6 21.6 0.74 9.8 17.3 1.5 2 0 0 2 2 2 0 Mucin-like glycoprotein LRR_6 PF13516.6 EFA85421.1 - 1.2e-05 25.0 3.7 1.8e-05 24.4 0.1 3.1 3 0 0 3 3 3 1 Leucine Rich repeat AAA_18 PF13238.6 EFA85422.1 - 5.4e-08 33.4 0.7 4.6e-07 30.4 0.7 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFA85422.1 - 1.2e-06 28.8 0.0 1.8e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EFA85422.1 - 2.5e-05 23.9 0.2 0.00046 19.7 0.0 2.2 2 0 0 2 2 2 1 Chromatin associated protein KTI12 PRK PF00485.18 EFA85422.1 - 0.00015 21.5 0.0 0.00051 19.8 0.0 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family 6PF2K PF01591.18 EFA85422.1 - 0.0011 18.3 0.8 0.0014 18.0 0.0 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase MeaB PF03308.16 EFA85422.1 - 0.0014 17.6 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EFA85422.1 - 0.0084 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 EFA85422.1 - 0.0085 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase NTPase_1 PF03266.15 EFA85422.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 NTPase Cytidylate_kin PF02224.18 EFA85422.1 - 0.015 15.0 0.3 0.061 13.0 0.1 1.9 2 0 0 2 2 2 0 Cytidylate kinase CbiA PF01656.23 EFA85422.1 - 0.022 14.8 0.1 0.054 13.5 0.1 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Med3 PF11593.8 EFA85422.1 - 0.03 13.5 6.6 0.044 13.0 6.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MMR_HSR1 PF01926.23 EFA85422.1 - 0.1 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Pterin_bind PF00809.22 EFA85424.1 - 1.5e-71 241.0 0.0 2e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EFA85424.1 - 4.3e-36 123.8 0.0 1.4e-35 122.2 0.0 1.9 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 EFA85424.1 - 3.7e-25 88.6 0.1 7.4e-25 87.7 0.1 1.5 1 0 0 1 1 1 1 Dihydroneopterin aldolase TAF4 PF05236.14 EFA85424.1 - 0.096 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Pyridoxal_deC PF00282.19 EFA85425.1 - 6.8e-17 61.2 0.1 2.2e-11 43.1 0.1 3.3 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain Cation_ATPase_C PF00689.21 EFA85426.1 - 8.1e-11 42.0 10.7 8.1e-11 42.0 10.7 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFA85426.1 - 0.0074 16.6 0.0 0.2 11.9 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EFA85426.1 - 0.022 14.9 0.6 0.2 11.8 0.0 3.0 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase FAD-oxidase_C PF02913.19 EFA85427.1 - 3.6e-58 197.1 0.0 4.7e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFA85427.1 - 4.8e-38 130.0 0.4 8.5e-38 129.2 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain DUF719 PF05334.13 EFA85428.1 - 0.012 15.8 3.1 0.012 15.8 3.1 5.4 4 2 1 5 5 5 0 Protein of unknown function (DUF719) DUF5349 PF17298.2 EFA85429.1 - 0.76 9.5 11.1 1 9.1 11.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5349) Nramp PF01566.18 EFA85430.1 - 2.4e-95 319.6 11.4 2.4e-95 319.6 11.4 2.0 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein GST_N PF02798.20 EFA85432.1 - 7.6e-12 45.4 0.1 1.4e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA85432.1 - 4.5e-10 39.6 0.1 8.2e-10 38.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFA85432.1 - 1.4e-09 38.1 0.1 3.6e-09 36.7 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA85432.1 - 2.5e-08 34.2 0.0 6.9e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFA85432.1 - 4.4e-07 30.1 0.0 9.2e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA85432.1 - 6.6e-05 22.8 0.0 0.00058 19.8 0.0 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain ACP_PD PF04336.12 EFA85432.1 - 0.014 15.8 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase Glutaredoxin PF00462.24 EFA85432.1 - 0.029 14.6 0.0 0.082 13.1 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin FNIP PF05725.12 EFA85434.1 - 6e-31 106.3 40.4 6.4e-07 29.4 0.1 9.7 5 2 6 11 11 11 9 FNIP Repeat rve PF00665.26 EFA85436.1 - 0.00017 21.8 0.0 0.0003 21.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain CBM49 PF09478.10 EFA85437.1 - 3.8e-09 36.7 0.0 3.8e-09 36.7 0.0 2.6 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 TIG PF01833.24 EFA85438.1 - 0.00012 22.1 4.1 0.00012 22.1 4.1 2.6 2 0 0 2 2 2 1 IPT/TIG domain TIG PF01833.24 EFA85439.1 - 2.2e-74 245.6 73.2 3.3e-12 46.3 6.2 11.0 9 1 0 9 9 9 9 IPT/TIG domain SseC PF04888.12 EFA85439.1 - 0.0075 15.9 1.6 0.012 15.3 1.6 1.2 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family CENP-B_dimeris PF09026.10 EFA85439.1 - 8.7 6.8 8.0 17 5.9 8.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4579 PF15158.6 EFA85440.1 - 0.12 12.1 0.1 0.13 12.1 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) Itfg2 PF15907.5 EFA85441.1 - 7.1e-25 87.7 4.0 1.7e-23 83.2 0.1 2.7 2 1 1 3 3 3 2 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 EFA85441.1 - 6.4e-09 35.8 0.7 0.005 16.8 0.1 2.9 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.23 EFA85441.1 - 9.1e-07 28.9 0.5 0.013 15.6 0.1 2.6 2 0 0 2 2 2 2 FG-GAP repeat PHTB1_N PF14727.6 EFA85441.1 - 2.3e-05 23.9 0.2 5.1e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 PTHB1 N-terminus BBS1 PF14779.6 EFA85441.1 - 7.7e-05 22.2 0.0 0.029 13.8 0.0 2.2 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 1 VCBS PF13517.6 EFA85441.1 - 0.00012 22.6 4.6 0.12 13.0 0.1 3.1 2 1 1 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Spt20 PF12090.8 EFA85441.1 - 0.0075 15.9 11.7 0.014 15.0 11.7 1.3 1 0 0 1 1 1 1 Spt20 family Presenilin PF01080.17 EFA85441.1 - 0.014 14.1 2.0 0.022 13.5 2.0 1.2 1 0 0 1 1 1 0 Presenilin BBS2_C PF14782.6 EFA85441.1 - 0.036 12.8 3.6 0.25 10.1 0.6 2.7 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, C-terminal PliI PF16743.5 EFA85441.1 - 0.054 13.2 0.4 1.1 9.1 0.0 2.7 2 1 1 3 3 3 0 Periplasmic lysozyme inhibitor of I-type lysozyme NPR3 PF03666.13 EFA85441.1 - 0.3 9.8 4.6 0.39 9.4 4.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 EFA85441.1 - 0.31 10.2 0.6 0.43 9.7 0.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Apc15p PF05841.11 EFA85441.1 - 0.77 10.6 14.2 0.15 12.9 10.1 1.8 2 0 0 2 2 2 0 Apc15p protein Menin PF05053.13 EFA85441.1 - 0.92 7.8 7.3 1.3 7.3 7.3 1.1 1 0 0 1 1 1 0 Menin DUF4834 PF16118.5 EFA85441.1 - 3.1 8.8 11.1 0.94 10.5 8.2 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) ALMT PF11744.8 EFA85441.1 - 6.2 5.5 6.9 9.4 4.9 6.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_12 PF13087.6 EFA85442.1 - 6.3e-60 202.2 0.1 1.3e-59 201.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFA85442.1 - 3.5e-50 171.2 0.1 3.7e-27 95.8 0.0 3.6 3 1 1 4 4 4 2 AAA domain AAA_30 PF13604.6 EFA85442.1 - 1.4e-11 44.5 0.0 3.7e-11 43.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA85442.1 - 4.8e-11 43.2 0.0 2.9e-10 40.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain PAP_assoc PF03828.19 EFA85442.1 - 2.5e-10 40.4 0.5 2.5e-10 40.4 0.5 2.3 2 0 0 2 2 1 1 Cid1 family poly A polymerase Viral_helicase1 PF01443.18 EFA85442.1 - 5.6e-06 26.3 0.0 0.44 10.2 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase NTP_transf_2 PF01909.23 EFA85442.1 - 0.0056 16.9 0.0 0.023 15.0 0.0 2.1 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFA85442.1 - 0.013 15.6 0.2 0.22 11.6 0.0 2.8 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase UvrD_C_2 PF13538.6 EFA85442.1 - 0.024 14.5 0.0 0.051 13.4 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain PAP_central PF04928.17 EFA85442.1 - 0.043 12.8 0.3 6.3 5.7 0.0 2.8 3 0 0 3 3 3 0 Poly(A) polymerase central domain PhoH PF02562.16 EFA85442.1 - 0.05 13.0 0.0 2.7 7.4 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein UvrD-helicase PF00580.21 EFA85442.1 - 0.073 12.6 0.0 0.073 12.6 0.0 4.0 4 2 0 5 5 5 0 UvrD/REP helicase N-terminal domain AAA_6 PF12774.7 EFA85442.1 - 0.088 11.8 0.0 0.21 10.5 0.0 1.6 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region T2SSE PF00437.20 EFA85442.1 - 0.11 11.6 0.0 0.23 10.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RRN3 PF05327.11 EFA85442.1 - 0.18 10.3 7.6 0.41 9.1 7.6 1.6 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CLZ PF16526.5 EFA85442.1 - 2.5 8.5 6.9 1.7 9.0 0.3 3.7 4 0 0 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AAA_12 PF13087.6 EFA85443.1 - 2e-60 203.8 0.4 4.4e-60 202.7 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFA85443.1 - 2.9e-53 181.3 4.1 3.7e-27 95.8 0.0 3.5 2 1 1 3 3 3 2 AAA domain AAA_19 PF13245.6 EFA85443.1 - 3e-13 50.4 0.0 1.1e-11 45.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFA85443.1 - 7.6e-13 48.6 0.0 1.7e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain PAP_assoc PF03828.19 EFA85443.1 - 1.1e-09 38.3 2.8 1.3e-09 38.1 0.8 2.3 2 0 0 2 2 2 1 Cid1 family poly A polymerase Viral_helicase1 PF01443.18 EFA85443.1 - 1.3e-06 28.3 0.0 0.22 11.2 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 EFA85443.1 - 1.8e-05 24.4 2.3 0.012 15.2 0.0 4.1 3 1 1 4 4 4 1 UvrD/REP helicase N-terminal domain Nrap_D2 PF17403.2 EFA85443.1 - 0.0014 18.5 0.5 0.0014 18.5 0.5 2.1 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain PhoH PF02562.16 EFA85443.1 - 0.0014 18.1 0.0 0.027 13.9 0.0 2.4 1 1 0 1 1 1 1 PhoH-like protein Polbeta PF18765.1 EFA85443.1 - 0.015 15.4 0.0 0.069 13.2 0.0 2.2 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase UvrD_C_2 PF13538.6 EFA85443.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain NTP_transf_2 PF01909.23 EFA85443.1 - 0.037 14.3 0.0 0.13 12.6 0.0 1.9 1 0 0 1 1 1 0 Nucleotidyltransferase domain AAA_6 PF12774.7 EFA85443.1 - 0.067 12.2 0.0 0.17 10.8 0.0 1.6 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region UvrD_C PF13361.6 EFA85443.1 - 0.096 12.0 1.9 4 6.7 0.0 3.1 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain PAP_central PF04928.17 EFA85443.1 - 0.11 11.5 1.0 2.8 6.8 0.0 3.0 3 0 0 3 3 3 0 Poly(A) polymerase central domain HrpB7 PF09486.10 EFA85444.1 - 4.5 7.7 16.4 0.38 11.1 0.7 3.4 1 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) MMR_HSR1_C PF08438.10 EFA85445.1 - 3.5e-38 130.6 0.1 6e-38 129.9 0.1 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EFA85445.1 - 1.1e-21 77.1 0.0 2.4e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA85445.1 - 9.4e-11 41.5 0.3 1.4e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B TGS PF02824.21 EFA85445.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 TGS domain YchF-GTPase_C PF06071.13 EFA85445.1 - 0.014 15.5 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF933) Dynamin_N PF00350.23 EFA85445.1 - 0.027 14.5 0.0 0.076 13.1 0.0 1.7 1 0 0 1 1 1 0 Dynamin family MMR_HSR1_Xtn PF16897.5 EFA85445.1 - 0.055 13.5 0.2 0.12 12.4 0.2 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 EFA85445.1 - 0.12 12.1 0.9 1.3 8.7 0.2 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFA85445.1 - 0.13 12.1 0.1 4.1 7.3 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase SlyX PF04102.12 EFA85446.1 - 0.0085 16.7 0.5 0.0085 16.7 0.5 3.1 2 1 1 3 3 3 1 SlyX ACP PF06857.11 EFA85446.1 - 0.18 12.1 1.5 1.9 8.8 0.4 2.3 2 0 0 2 2 2 0 Malonate decarboxylase delta subunit (MdcD) GyrB_insert PF18053.1 EFA85446.1 - 0.56 10.1 7.7 0.58 10.0 6.1 1.8 1 1 1 2 2 2 0 DNA gyrase B subunit insert domain XRN_M PF17846.1 EFA85446.1 - 1.6 7.6 12.1 2.1 7.2 12.1 1.3 1 0 0 1 1 1 0 Xrn1 helical domain ACT_5 PF13710.6 EFA85446.1 - 1.6 8.6 6.9 8.8 6.3 1.1 2.7 1 1 1 2 2 2 0 ACT domain Fib_alpha PF08702.10 EFA85446.1 - 6.9 6.8 25.0 9.1 6.5 5.0 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family zf-Nse PF11789.8 EFA85447.1 - 0.1 12.4 0.5 0.25 11.2 0.5 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Chorion_2 PF03964.15 EFA85447.1 - 1.3 9.9 7.3 6.1 7.7 2.3 2.8 2 0 0 2 2 2 0 Chorion family 2 ER_lumen_recept PF00810.18 EFA85448.1 - 2.4e-57 193.9 13.3 2.4e-57 193.9 13.3 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EFA85448.1 - 0.032 14.0 1.0 0.032 14.0 1.0 3.5 3 1 1 4 4 4 0 PQ loop repeat TMEM238 PF15125.6 EFA85448.1 - 0.2 11.9 5.2 0.079 13.2 1.9 2.1 2 0 0 2 2 2 0 TMEM238 protein family Presenilin PF01080.17 EFA85448.1 - 2.4 6.8 9.0 3.2 6.4 9.0 1.1 1 0 0 1 1 1 0 Presenilin TIG PF01833.24 EFA85449.1 - 7.4e-18 64.4 41.3 3.4e-06 27.0 0.6 7.2 7 0 0 7 7 7 4 IPT/TIG domain Lectin_C PF00059.21 EFA85449.1 - 6.8e-10 39.6 0.1 0.00013 22.7 0.0 2.9 2 0 0 2 2 2 2 Lectin C-type domain EGF_2 PF07974.13 EFA85449.1 - 5e-07 30.0 33.2 0.004 17.5 12.6 2.8 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EFA85449.1 - 0.0062 17.1 29.1 0.61 10.8 10.6 3.3 2 0 0 2 2 2 2 Human growth factor-like EGF IL17R_fnIII_D2 PF16578.5 EFA85449.1 - 0.069 13.7 1.2 22 5.6 0.1 3.0 2 0 0 2 2 2 0 Interleukin 17 receptor D DUF3040 PF11239.8 EFA85449.1 - 0.1 12.9 0.1 8 6.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) cEGF PF12662.7 EFA85449.1 - 0.11 12.5 4.9 7.1 6.7 0.4 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like CsgG PF03783.14 EFA85449.1 - 0.2 10.9 2.8 7.9 5.7 0.2 2.7 3 0 0 3 3 3 0 Curli production assembly/transport component CsgG RNase_PH_C PF03725.15 EFA85449.1 - 0.21 11.6 0.5 40 4.3 0.0 3.0 3 0 0 3 3 3 0 3' exoribonuclease family, domain 2 DUF5115 PF17142.4 EFA85449.1 - 0.49 10.0 7.6 2.9 7.5 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5115) DUF647 PF04884.14 EFA85450.1 - 1.6e-60 204.7 0.2 2.5e-60 204.1 0.2 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis HMG_box PF00505.19 EFA85451.1 - 5.5e-05 23.5 1.8 5.5e-05 23.5 1.8 3.6 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFA85451.1 - 0.0014 19.2 3.2 0.0014 19.2 3.2 3.3 2 0 0 2 2 2 1 HMG-box domain adh_short PF00106.25 EFA85452.1 - 2.6e-47 160.8 0.0 3.4e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA85452.1 - 4.9e-34 117.9 0.1 6.1e-34 117.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA85452.1 - 1.2e-11 44.9 0.1 1.7e-11 44.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA85452.1 - 9.8e-06 25.2 0.3 6e-05 22.6 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA85452.1 - 0.0022 17.9 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding ADH_zinc_N PF00107.26 EFA85452.1 - 0.005 16.8 0.1 0.024 14.6 0.0 2.1 2 1 0 2 2 2 1 Zinc-binding dehydrogenase DUF1776 PF08643.10 EFA85452.1 - 0.0094 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 EFA85452.1 - 0.01 14.9 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain AMP-binding PF00501.28 EFA85454.1 - 1.6e-100 336.6 0.0 2.3e-100 336.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme WD40 PF00400.32 EFA85454.1 - 4.7e-35 119.0 31.6 5.7e-07 30.1 0.9 8.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85454.1 - 1e-14 54.6 5.8 0.0027 18.0 0.0 5.9 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA85454.1 - 1.7e-07 30.3 10.7 0.16 10.6 0.3 5.1 3 1 1 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 EFA85454.1 - 3.7e-06 26.5 9.6 4e-06 26.4 0.1 3.3 4 0 0 4 4 4 2 WD40-like domain AMP-binding_C PF13193.6 EFA85454.1 - 0.00034 21.5 0.0 0.00078 20.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CAP_N PF01213.19 EFA85454.1 - 0.0038 16.8 0.0 0.0052 16.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal PQQ_2 PF13360.6 EFA85454.1 - 0.043 13.4 0.2 1.6 8.2 0.0 2.5 1 1 1 2 2 2 0 PQQ-like domain Repressor_Mnt PF11423.8 EFA85454.1 - 0.3 10.9 0.8 21 5.0 0.1 2.6 2 0 0 2 2 2 0 Regulatory protein Mnt Vut_1 PF02592.15 EFA85454.1 - 0.54 10.6 2.1 0.56 10.5 0.0 2.0 2 0 0 2 2 2 0 Putative vitamin uptake transporter F-box PF00646.33 EFA85455.1 - 0.00042 20.1 0.2 0.001 18.8 0.2 1.7 1 0 0 1 1 1 1 F-box domain CM_2 PF01817.21 EFA85455.1 - 0.0045 17.3 0.1 0.0086 16.4 0.1 1.5 1 0 0 1 1 1 1 Chorismate mutase type II F-box-like PF12937.7 EFA85455.1 - 0.018 14.9 1.1 0.023 14.6 0.1 1.7 2 0 0 2 2 2 0 F-box-like PRANC PF09372.10 EFA85455.1 - 0.067 13.5 0.7 0.14 12.5 0.7 1.7 1 1 0 1 1 1 0 PRANC domain CBM49 PF09478.10 EFA85456.1 - 1.6e-15 57.1 9.0 3.3e-05 24.1 3.1 5.2 5 0 0 5 5 5 5 Carbohydrate binding domain CBM49 WD40 PF00400.32 EFA85457.1 - 1.5e-20 73.1 20.3 0.0015 19.3 0.1 6.6 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85457.1 - 5.2e-09 36.3 8.3 0.011 16.0 0.3 4.4 2 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFA85457.1 - 0.011 14.7 1.9 2.9 6.7 0.0 3.6 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EFA85457.1 - 0.12 12.4 0.6 13 5.9 0.2 3.4 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region AAA PF00004.29 EFA85458.1 - 4.4e-39 133.9 0.0 1.4e-38 132.3 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFA85458.1 - 2.8e-28 97.7 0.1 2e-26 91.7 0.1 2.8 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EFA85458.1 - 1.2e-20 73.3 6.7 1.2e-20 73.3 6.7 1.9 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EFA85458.1 - 4.7e-09 35.9 0.0 1.2e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EFA85458.1 - 7.9e-06 25.7 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EFA85458.1 - 4.3e-05 22.8 0.0 7.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EFA85458.1 - 4.9e-05 23.8 0.0 0.00013 22.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EFA85458.1 - 0.00013 22.2 0.1 0.0006 20.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EFA85458.1 - 0.00017 21.0 0.0 0.00029 20.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EFA85458.1 - 0.00024 21.1 0.0 0.00061 19.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFA85458.1 - 0.00025 21.3 2.9 0.046 14.0 0.0 2.7 2 1 1 3 3 2 1 AAA domain RNA_helicase PF00910.22 EFA85458.1 - 0.00042 20.7 0.0 0.0014 19.0 0.0 2.0 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EFA85458.1 - 0.00049 20.1 0.0 0.0016 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFA85458.1 - 0.00066 19.5 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 EFA85458.1 - 0.0039 16.9 0.9 0.0079 15.9 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFA85458.1 - 0.0042 17.6 0.2 0.017 15.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFA85458.1 - 0.0049 17.0 0.9 0.089 12.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain Tma16 PF11176.8 EFA85458.1 - 0.015 15.2 1.5 0.039 13.8 1.5 1.7 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Mg_chelatase PF01078.21 EFA85458.1 - 0.018 14.4 0.0 0.064 12.6 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EFA85458.1 - 0.033 13.9 0.0 0.83 9.3 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain Use1 PF09753.9 EFA85458.1 - 0.035 13.8 4.6 0.031 14.0 3.2 1.6 2 0 0 2 2 2 0 Membrane fusion protein Use1 Parvo_NS1 PF01057.17 EFA85458.1 - 0.035 13.2 0.0 0.073 12.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EFA85458.1 - 0.041 13.5 0.6 0.22 11.1 0.1 2.3 2 1 1 3 3 3 0 AAA domain NACHT PF05729.12 EFA85458.1 - 0.041 13.8 0.0 0.63 9.9 0.0 2.2 1 1 1 2 2 2 0 NACHT domain Viral_helicase1 PF01443.18 EFA85458.1 - 0.05 13.3 0.0 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase CSF-1 PF05337.11 EFA85458.1 - 0.052 13.6 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) AAA_17 PF13207.6 EFA85458.1 - 0.068 13.6 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EFA85458.1 - 0.07 12.5 0.2 9.6 5.6 0.0 2.7 3 0 0 3 3 3 0 Bacterial TniB protein Torsin PF06309.11 EFA85458.1 - 0.07 13.2 0.0 0.21 11.7 0.0 1.8 2 0 0 2 2 1 0 Torsin PhoH PF02562.16 EFA85458.1 - 0.077 12.4 0.2 0.22 10.9 0.0 1.8 2 0 0 2 2 1 0 PhoH-like protein AAA_30 PF13604.6 EFA85458.1 - 0.1 12.3 0.0 0.34 10.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA85458.1 - 0.11 13.1 0.2 0.95 10.0 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 EFA85458.1 - 0.11 12.0 0.0 0.35 10.4 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EFA85458.1 - 0.14 12.0 2.7 2.4 8.0 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EFA85458.1 - 0.14 11.5 2.2 11 5.3 0.1 2.7 2 1 1 3 3 2 0 KaiC Sigma54_activ_2 PF14532.6 EFA85458.1 - 0.17 12.0 0.0 0.53 10.4 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain TP53IP5 PF15331.6 EFA85458.1 - 1.8 8.7 6.0 4.3 7.4 0.1 2.2 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 SIKE PF05769.11 EFA85459.1 - 0.0068 16.3 46.3 33 4.3 46.2 2.9 1 1 0 1 1 1 1 SIKE family Ank_2 PF12796.7 EFA85460.1 - 3.3e-35 120.5 21.5 4.4e-11 43.2 3.1 4.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA85460.1 - 6e-21 74.2 7.1 2.9e-07 30.7 0.0 4.7 3 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA85460.1 - 2.2e-19 69.5 3.3 3e-06 27.7 0.1 4.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85460.1 - 2.1e-16 58.3 3.4 0.0051 17.2 0.0 5.9 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFA85460.1 - 1.5e-12 47.3 9.3 0.0033 17.8 0.6 6.5 6 0 0 6 6 6 3 Ankyrin repeat DUF249 PF03158.13 EFA85460.1 - 0.013 15.3 0.0 0.081 12.6 0.0 2.0 1 1 1 2 2 2 0 Multigene family 530 protein Neurochondrin PF05536.11 EFA85461.1 - 3.2e-33 115.0 4.7 1.5e-18 66.5 1.2 2.6 2 1 1 3 3 3 2 Neurochondrin DUF1180 PF06679.12 EFA85461.1 - 0.49 10.8 9.5 3.9 7.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Orf78 PF06024.12 EFA85461.1 - 2 8.8 12.7 1.4 9.3 1.9 3.4 3 1 0 3 3 3 0 Orf78 (ac78) Zip PF02535.22 EFA85461.1 - 2.1 7.5 7.0 0.65 9.1 0.3 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3527 PF12043.8 EFA85461.1 - 3.4 7.1 13.3 1.2 8.7 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3527) MID_MedPIWI PF18296.1 EFA85461.1 - 3.7 7.3 24.4 0.48 10.2 6.6 3.2 3 0 0 3 3 3 0 MID domain of medPIWI Velvet PF11754.8 EFA85461.1 - 5.6 6.8 12.2 2.5 8.0 2.0 2.2 2 0 0 2 2 2 0 Velvet factor Ank_2 PF12796.7 EFA85463.1 - 3.5e-14 53.1 3.5 0.00037 21.0 0.0 4.4 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85463.1 - 2.1e-12 47.3 3.6 0.081 13.5 0.0 6.6 5 2 1 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85463.1 - 2.4e-07 30.5 0.8 23 6.0 0.0 7.7 10 0 0 10 10 10 1 Ankyrin repeat Ank_5 PF13857.6 EFA85463.1 - 2.7e-05 24.4 7.3 2.5 8.5 0.1 6.5 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Kelch_6 PF13964.6 EFA85464.1 - 7.7e-40 133.9 14.7 5.2e-11 42.4 0.0 6.4 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EFA85464.1 - 3.1e-39 132.3 12.0 3.1e-08 33.1 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFA85464.1 - 3.4e-38 129.4 13.8 1.5e-13 50.5 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA85464.1 - 9.3e-36 121.3 10.1 1.7e-07 31.1 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFA85464.1 - 2.1e-32 110.8 25.7 6.5e-08 32.7 0.0 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA85464.1 - 2.3e-32 109.7 18.7 3.3e-07 30.0 0.1 6.3 6 0 0 6 6 6 6 Kelch motif FLgD_tudor PF13861.6 EFA85464.1 - 0.019 15.2 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 FlgD Tudor-like domain Kinesin PF00225.23 EFA85465.1 - 2e-104 349.1 2.1 2e-104 349.1 2.1 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFA85465.1 - 1.4e-23 83.5 0.3 1.4e-23 83.5 0.3 2.9 3 1 0 3 3 3 1 Microtubule binding HOOK PF05622.12 EFA85465.1 - 0.0011 17.2 12.3 0.0011 17.2 12.3 2.1 2 0 0 2 2 2 1 HOOK protein Dna2 PF08696.11 EFA85465.1 - 0.015 15.1 2.1 0.015 15.1 2.1 2.2 2 1 0 2 2 2 0 DNA replication factor Dna2 PKcGMP_CC PF16808.5 EFA85465.1 - 0.032 14.1 15.9 0.071 13.0 0.2 4.0 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MscS_porin PF12795.7 EFA85465.1 - 0.73 9.3 28.7 0.1 12.1 14.7 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain GAS PF13851.6 EFA85465.1 - 3.1 7.1 37.2 0.68 9.3 8.0 2.8 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Pox_A_type_inc PF04508.12 EFA85465.1 - 5.6 7.0 14.2 4.5 7.3 0.4 4.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF16 PF01519.16 EFA85465.1 - 7.4 7.1 24.5 0.041 14.4 10.4 2.9 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4367 PF14285.6 EFA85465.1 - 8.8 6.8 13.4 1.3 9.5 8.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) Acetyltransf_4 PF13420.7 EFA85466.1 - 1.1e-15 58.1 0.0 1.5e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA85466.1 - 2.2e-12 47.3 0.0 3e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFA85466.1 - 1.3e-07 31.9 0.0 2.2e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFA85466.1 - 1e-06 29.5 0.0 1.2e-06 29.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA85466.1 - 5.4e-05 23.1 0.0 8.9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EFA85466.1 - 9.1e-05 22.4 0.0 0.00015 21.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EFA85466.1 - 0.0041 16.7 0.0 0.0057 16.2 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_6 PF13480.7 EFA85466.1 - 0.0095 16.1 0.6 0.024 14.8 0.6 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain IBR PF01485.21 EFA85467.1 - 5.2e-20 71.4 25.0 1.7e-11 44.2 11.3 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_11 PF17123.5 EFA85467.1 - 0.029 14.1 4.2 0.11 12.3 4.2 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EFA85467.1 - 0.12 12.2 45.0 0.12 12.3 10.0 4.7 5 0 0 5 5 5 0 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EFA85468.1 - 4.2e-08 32.9 0.0 1.1e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WTX PF09422.10 EFA85468.1 - 0.0026 16.9 8.9 0.0027 16.9 8.9 1.2 1 0 0 1 1 1 1 WTX protein UPF0560 PF10577.9 EFA85468.1 - 3.4 6.1 12.8 3.6 6.0 12.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RRM_1 PF00076.22 EFA85469.1 - 0.0049 16.7 2.7 0.013 15.3 0.1 2.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.9 EFA85469.1 - 2 8.0 9.1 0.36 10.4 5.0 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Arm PF00514.23 EFA85470.1 - 2.9e-82 268.5 20.3 2.1e-11 43.5 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFA85470.1 - 1.4e-23 83.0 0.9 1.7e-07 31.6 0.1 5.9 5 2 1 6 6 5 4 HEAT-like repeat HEAT_2 PF13646.6 EFA85470.1 - 7e-18 64.8 0.0 2.1e-07 31.2 0.0 4.6 2 2 2 4 4 4 4 HEAT repeats IBB PF01749.20 EFA85470.1 - 1.1e-16 61.0 4.2 3.1e-16 59.6 4.2 1.8 1 0 0 1 1 1 1 Importin beta binding domain HEAT PF02985.22 EFA85470.1 - 1.2e-14 53.1 1.5 0.0002 21.3 0.0 7.0 8 0 0 8 8 8 4 HEAT repeat Arm_3 PF16186.5 EFA85470.1 - 1.1e-13 50.5 0.3 3.6e-13 48.8 0.3 1.9 1 0 0 1 1 1 1 Atypical Arm repeat Arm_2 PF04826.13 EFA85470.1 - 1.1e-05 25.0 1.6 0.056 12.9 0.8 3.0 1 1 2 3 3 3 3 Armadillo-like V-ATPase_H_C PF11698.8 EFA85470.1 - 8.2e-05 22.7 0.1 1.4 9.0 0.0 4.1 4 0 0 4 4 4 1 V-ATPase subunit H NopRA1 PF16201.5 EFA85470.1 - 0.00047 19.8 0.0 2.7 7.5 0.0 4.4 3 2 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 HEAT_PBS PF03130.16 EFA85470.1 - 0.0036 17.8 1.0 0.86 10.5 0.0 4.4 5 0 0 5 5 3 1 PBS lyase HEAT-like repeat RICTOR_V PF14668.6 EFA85470.1 - 0.0048 17.1 4.9 5.2 7.4 0.1 4.5 3 2 3 6 6 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 EFA85470.1 - 0.0051 16.8 0.8 0.75 9.9 0.0 3.6 4 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Mo25 PF08569.11 EFA85470.1 - 0.0068 15.8 0.0 0.028 13.8 0.0 1.9 1 1 0 2 2 2 1 Mo25-like Snurportin1 PF11538.8 EFA85470.1 - 3.3 8.0 6.1 6.5 7.0 6.1 1.5 1 0 0 1 1 1 0 Snurportin1 G-patch PF01585.23 EFA85471.1 - 9.6e-11 41.4 1.3 9.6e-11 41.4 1.3 1.9 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EFA85471.1 - 0.0016 18.5 0.1 0.0016 18.5 0.1 3.9 5 0 0 5 5 5 1 G-patch domain CBM49 PF09478.10 EFA85472.1 - 4.9e-17 62.0 3.5 9.5e-17 61.1 3.5 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 TMEM223 PF14640.6 EFA85473.1 - 1.8e-06 28.3 0.5 1.8e-06 28.3 0.5 2.5 2 1 1 3 3 3 1 Transmembrane protein 223 Presenilin PF01080.17 EFA85473.1 - 0.0074 15.1 4.7 0.0096 14.7 4.7 1.1 1 0 0 1 1 1 1 Presenilin NPR3 PF03666.13 EFA85473.1 - 0.015 14.1 5.2 0.02 13.7 5.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ASD2 PF08687.11 EFA85473.1 - 0.061 12.9 4.6 0.092 12.3 4.6 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Macoilin PF09726.9 EFA85473.1 - 0.71 8.4 17.0 0.91 8.0 17.0 1.1 1 0 0 1 1 1 0 Macoilin family MMU163 PF17119.5 EFA85473.1 - 1.1 8.4 5.0 1.5 7.9 5.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Spt20 PF12090.8 EFA85473.1 - 1.2 8.7 23.0 2.1 7.9 23.0 1.4 1 0 0 1 1 1 0 Spt20 family Gti1_Pac2 PF09729.9 EFA85473.1 - 1.3 9.1 11.9 2.1 8.4 11.9 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4820 PF16091.5 EFA85473.1 - 1.3 8.3 6.0 2 7.7 5.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Menin PF05053.13 EFA85473.1 - 2.1 6.6 15.5 3.1 6.1 15.5 1.2 1 0 0 1 1 1 0 Menin HCO3_cotransp PF00955.21 EFA85473.1 - 4.8 5.9 9.4 8.2 5.1 9.4 1.4 1 0 0 1 1 1 0 HCO3- transporter family Ctr PF04145.15 EFA85474.1 - 0.0006 20.5 0.3 0.2 12.3 0.1 2.3 2 0 0 2 2 2 2 Ctr copper transporter family NnrU PF07298.11 EFA85474.1 - 0.012 15.1 1.6 0.21 11.0 1.6 2.3 1 1 0 1 1 1 0 NnrU protein DivIC PF04977.15 EFA85474.1 - 0.037 13.8 1.3 0.037 13.8 1.3 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF4834 PF16118.5 EFA85474.1 - 0.056 14.4 13.4 0.51 11.3 0.7 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) Renin_r PF07850.14 EFA85474.1 - 4.2 8.0 7.4 1.5 9.4 1.0 2.6 2 1 0 2 2 2 0 Renin receptor-like protein Folliculin PF11704.8 EFA85475.1 - 0.00017 21.5 0.0 0.00017 21.5 0.0 3.9 3 1 0 3 3 3 1 Vesicle coat protein involved in Golgi to plasma membrane transport DUF3439 PF11921.8 EFA85476.1 - 0.65 10.0 3.7 0.63 10.0 2.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) MRAP PF15183.6 EFA85477.1 - 0.047 13.7 1.5 0.065 13.2 0.0 2.0 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family DUF4389 PF14333.6 EFA85477.1 - 0.11 12.4 0.3 0.26 11.2 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) CaKB PF03185.15 EFA85477.1 - 0.28 10.8 2.6 1 9.0 0.5 2.2 2 0 0 2 2 2 0 Calcium-activated potassium channel, beta subunit ODV-E18 PF10717.9 EFA85477.1 - 2.7 7.9 7.6 0.51 10.2 0.3 2.7 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 YjbE PF11106.8 EFA85477.1 - 4.4 7.6 10.0 1.7 8.9 0.9 2.4 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE TMEM154 PF15102.6 EFA85478.1 - 2.3e-05 24.3 1.0 7.5e-05 22.7 0.3 2.0 2 0 0 2 2 2 1 TMEM154 protein family EphA2_TM PF14575.6 EFA85478.1 - 0.0014 19.5 3.2 0.01 16.7 1.5 2.3 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 EFA85478.1 - 0.0026 17.4 0.2 0.0043 16.7 0.2 1.3 1 0 0 1 1 1 1 FAM176 family DUF4064 PF13273.6 EFA85478.1 - 0.02 15.2 0.6 0.4 11.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF5122 PF17164.4 EFA85478.1 - 0.022 15.0 0.4 0.083 13.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller Cadherin_C_2 PF16492.5 EFA85478.1 - 0.025 15.3 6.1 0.033 14.9 2.5 2.3 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Ly49 PF08391.10 EFA85478.1 - 0.038 14.4 2.6 0.35 11.2 1.8 2.3 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region MpPF26 PF07666.11 EFA85478.1 - 0.04 14.0 0.6 0.04 14.0 0.6 2.5 2 1 0 2 2 2 0 M penetrans paralogue family 26 Baculo_11_kDa PF06143.11 EFA85478.1 - 0.07 12.7 2.8 0.062 12.9 1.1 1.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF4834 PF16118.5 EFA85478.1 - 0.086 13.8 0.6 0.27 12.2 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Protocadherin PF08374.11 EFA85478.1 - 0.089 12.8 1.3 0.12 12.4 0.3 1.7 2 0 0 2 2 2 0 Protocadherin T2SSF PF00482.23 EFA85478.1 - 2.3 8.2 3.3 1.2 9.1 0.1 1.9 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F zf-RING_2 PF13639.6 EFA85479.1 - 4.9e-11 42.8 11.5 8.7e-11 42.0 11.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA85479.1 - 8.7e-10 38.3 10.1 1.5e-09 37.6 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA85479.1 - 5.1e-09 35.9 13.5 1e-08 34.9 13.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA85479.1 - 8.7e-08 32.3 8.3 2.1e-07 31.1 8.3 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFA85479.1 - 1.1e-06 28.4 9.0 1.6e-06 27.9 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA85479.1 - 8.1e-06 25.8 7.9 1.9e-05 24.6 7.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFA85479.1 - 2.3e-05 24.2 8.4 4.9e-05 23.1 8.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFA85479.1 - 0.0002 21.2 10.7 0.00039 20.3 10.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EFA85479.1 - 0.00039 20.1 11.2 0.00092 18.9 11.2 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 EFA85479.1 - 0.0036 17.4 10.5 0.0092 16.1 10.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING IBP39 PF11422.8 EFA85479.1 - 0.0085 15.9 0.6 0.016 15.0 0.6 1.4 1 0 0 1 1 1 1 Initiator binding protein 39 kDa zf-RING_10 PF16685.5 EFA85479.1 - 0.019 15.1 5.9 0.059 13.5 5.9 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.8 EFA85479.1 - 0.035 13.9 8.7 0.058 13.2 6.8 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EFA85479.1 - 0.055 13.3 6.4 0.12 12.2 6.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EFA85479.1 - 0.12 12.0 9.8 0.33 10.6 9.8 1.7 1 0 0 1 1 1 0 P-11 zinc finger Siva PF05458.12 EFA85479.1 - 0.37 10.5 4.1 0.59 9.8 4.1 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-ANAPC11 PF12861.7 EFA85479.1 - 0.45 10.6 6.6 1.2 9.3 6.6 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1272 PF06906.11 EFA85479.1 - 0.61 10.2 6.4 1.2 9.2 6.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Kelch_1 PF01344.25 EFA85480.1 - 1.6e-29 101.2 18.5 2.7e-10 39.6 0.5 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFA85480.1 - 9.7e-29 98.7 20.0 2.9e-07 30.5 0.4 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EFA85480.1 - 3.4e-27 94.0 14.9 4.3e-07 29.8 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFA85480.1 - 6.9e-27 93.2 13.7 1.9e-07 31.0 0.4 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA85480.1 - 5e-24 83.3 12.3 6.5e-08 32.3 0.4 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFA85480.1 - 5.1e-16 58.5 24.0 0.00014 22.1 0.0 7.7 8 1 0 8 8 8 4 Galactose oxidase, central domain F-box PF00646.33 EFA85480.1 - 0.00065 19.5 0.3 0.0016 18.3 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA85480.1 - 0.0032 17.3 1.4 0.0072 16.2 0.0 2.3 3 0 0 3 3 3 1 F-box-like RAG2 PF03089.14 EFA85480.1 - 0.02 13.9 0.1 0.2 10.6 0.0 2.6 1 1 2 3 3 3 0 Recombination activating protein 2 Alpha_kinase PF02816.18 EFA85481.1 - 1.3e-59 201.5 0.1 1.3e-59 201.5 0.1 2.5 3 0 0 3 3 3 1 Alpha-kinase family WD40 PF00400.32 EFA85481.1 - 5.1e-37 125.2 16.4 1.3e-05 25.8 0.6 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat WD40_like PF17005.5 EFA85481.1 - 6.1e-10 38.9 1.6 0.00021 20.7 0.3 2.5 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 EFA85481.1 - 1.7e-09 36.9 5.4 0.08 11.6 0.1 4.9 2 2 3 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFA85481.1 - 2.3e-06 27.8 0.1 0.4 11.0 0.0 4.7 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EFA85481.1 - 0.0048 17.3 5.3 1.2 9.8 0.0 4.4 5 0 0 5 5 5 1 PQQ-like domain DUF1830 PF08865.11 EFA85481.1 - 0.11 12.5 0.1 27 4.9 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1830) DUF295 PF03478.18 EFA85481.1 - 0.16 11.6 0.5 0.55 9.9 0.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF295) NINJA_B PF16136.5 EFA85481.1 - 2.1 8.8 7.0 3.1 8.2 2.6 2.8 2 0 0 2 2 2 0 Putative nuclear localisation signal TIG PF01833.24 EFA85482.1 - 5e-57 190.0 74.8 4.1e-10 39.6 2.8 13.5 13 0 0 13 13 13 12 IPT/TIG domain DNase_II PF03265.15 EFA85482.1 - 2.4e-25 89.5 6.5 3.3e-24 85.8 3.2 3.1 2 1 0 2 2 2 2 Deoxyribonuclease II NUDIX PF00293.28 EFA85482.1 - 1.9e-11 44.1 0.1 4.1e-11 43.0 0.1 1.6 1 0 0 1 1 1 1 NUDIX domain LMF1 PF06762.14 EFA85483.1 - 1.2e-29 103.7 0.8 1.2e-29 103.7 0.8 2.0 2 0 0 2 2 2 1 Lipase maturation factor DUF5542 PF17696.1 EFA85483.1 - 0.0039 17.3 3.1 0.0039 17.3 3.1 2.0 3 0 0 3 3 3 1 Family of unknown function (DUF5542) Promethin PF16015.5 EFA85483.1 - 0.13 12.2 9.6 0.5 10.3 9.6 1.9 1 1 0 1 1 1 0 Promethin LAP1C PF05609.12 EFA85483.1 - 0.17 11.0 0.8 0.24 10.5 0.8 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dpy-30 PF05186.13 EFA85483.1 - 4.4 7.1 5.0 1.2 8.8 0.2 2.2 2 0 0 2 2 2 0 Dpy-30 motif LMF1 PF06762.14 EFA85484.1 - 5.6e-19 68.6 0.9 6.5e-19 68.4 0.9 1.1 1 0 0 1 1 1 1 Lipase maturation factor NeA_P2 PF12312.8 EFA85484.1 - 0.029 13.8 4.6 0.033 13.6 4.6 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein zf-UBR PF02207.20 EFA85485.1 - 2.8e-17 62.6 5.9 4.2e-17 62.1 5.9 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 EFA85485.1 - 0.1 12.8 2.1 0.31 11.2 2.1 1.7 1 1 0 1 1 1 0 B-box zinc finger DUF3439 PF11921.8 EFA85486.1 - 3.8 7.5 19.8 0.95 9.4 2.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF3439 PF11921.8 EFA85487.1 - 2.6 8.0 9.4 0.38 10.7 5.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Cyt-b5 PF00173.28 EFA85488.1 - 1.3e-11 44.5 0.0 1.9e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Tetraspanin PF00335.20 EFA85489.1 - 1.5e-05 24.9 16.7 1.5e-05 24.9 16.7 1.9 1 1 1 2 2 2 1 Tetraspanin family DUF2981 PF11200.8 EFA85489.1 - 0.12 12.1 8.4 0.18 11.5 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) WTF PF03303.13 EFA85489.1 - 1.5 8.5 8.6 1.8 8.3 8.6 1.2 1 0 0 1 1 1 0 WTF protein DHHC PF01529.20 EFA85489.1 - 5.2 7.2 15.9 5 7.2 3.2 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF2070 PF09843.9 EFA85489.1 - 6.2 5.0 13.1 7.1 4.8 13.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EF-hand_4 PF12763.7 EFA85490.1 - 1.5e-07 31.3 0.2 4.1e-07 29.9 0.2 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EFA85490.1 - 7e-05 22.1 0.6 0.1 12.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA85490.1 - 0.00017 21.2 0.4 0.47 10.5 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EFA85490.1 - 0.0025 18.2 1.9 0.15 12.5 0.3 2.1 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFA85490.1 - 0.017 14.6 0.1 0.13 11.8 0.0 2.1 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 EFA85490.1 - 0.019 14.8 0.2 4 7.4 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair PRMT5_TIM PF17285.2 EFA85493.1 - 3.3e-68 229.7 2.5 4.8e-68 229.1 2.5 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 EFA85493.1 - 1.1e-67 227.2 0.0 1.7e-67 226.6 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EFA85493.1 - 8.5e-54 182.1 5.2 1.6e-53 181.2 5.2 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 EFA85493.1 - 0.00029 21.5 0.0 0.00074 20.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EFA85493.1 - 0.00037 20.3 0.0 0.00066 19.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.6 EFA85493.1 - 0.0016 18.2 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA85493.1 - 0.043 14.5 0.0 0.11 13.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Trehalase PF01204.18 EFA85494.1 - 1.3e-105 354.2 3.3 1.5e-105 354.0 3.3 1.0 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 EFA85494.1 - 0.00026 20.0 0.2 0.00046 19.2 0.2 1.6 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Pkinase_Tyr PF07714.17 EFA85495.1 - 7e-58 195.9 0.0 1.5e-57 194.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA85495.1 - 4.7e-55 186.8 0.0 1e-54 185.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain B2 PF11473.8 EFA85495.1 - 0.027 14.3 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA binding protein B2 FH2 PF02181.23 EFA85496.1 - 2.4e-69 234.3 1.6 5.6e-69 233.0 0.7 2.0 2 0 0 2 2 2 1 Formin Homology 2 Domain DUF3361 PF11841.8 EFA85496.1 - 4e-10 39.8 5.3 6.1e-10 39.2 0.0 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF3361) Drf_GBD PF06371.13 EFA85496.1 - 3.3e-07 30.0 0.0 3.3e-07 30.0 0.0 2.8 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain DRIM PF07539.12 EFA85497.1 - 4.4e-84 283.0 16.0 4.4e-84 283.0 16.0 6.1 8 0 0 8 8 8 2 Down-regulated in metastasis HEAT PF02985.22 EFA85497.1 - 0.00043 20.3 0.0 6.5 7.3 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat Sec7_N PF12783.7 EFA85497.1 - 0.00076 19.4 1.6 0.00076 19.4 1.6 5.8 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Myc_N PF01056.18 EFA85497.1 - 0.0018 18.3 3.4 0.0018 18.3 3.4 5.2 6 0 0 6 6 6 1 Myc amino-terminal region Ribosomal_L31e PF01198.19 EFA85499.1 - 2.9e-30 104.3 3.0 3.8e-25 87.9 1.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L31e ABC_tran PF00005.27 EFA85500.1 - 1.2e-34 119.8 0.0 2.5e-16 60.4 0.0 2.7 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 EFA85500.1 - 3.7e-14 52.2 5.9 3.7e-14 52.2 5.9 1.9 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 EFA85500.1 - 1.2e-11 44.5 2.3 0.0015 18.0 0.2 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA85500.1 - 3.4e-10 40.2 4.6 0.18 11.6 0.1 4.2 2 2 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 EFA85500.1 - 1.6e-07 30.8 2.5 1.6e-07 30.8 2.5 2.6 3 0 0 3 3 2 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 EFA85500.1 - 1.5e-05 24.9 0.0 0.045 13.6 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 EFA85500.1 - 1.7e-05 25.2 0.0 0.082 13.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EFA85500.1 - 1.9e-05 24.5 1.1 0.13 11.9 0.0 3.3 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFA85500.1 - 2.1e-05 24.8 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFA85500.1 - 3.4e-05 24.3 0.0 0.23 11.8 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain Rad17 PF03215.15 EFA85500.1 - 5.6e-05 23.2 0.0 0.033 14.1 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain Fer4_6 PF12837.7 EFA85500.1 - 9.4e-05 22.3 12.4 0.00018 21.4 1.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.6 EFA85500.1 - 0.00035 20.2 0.2 1.1 9.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 EFA85500.1 - 0.00038 20.6 0.0 0.16 12.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFA85500.1 - 0.00072 19.5 0.2 0.5 10.3 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 EFA85500.1 - 0.0011 18.7 0.5 0.29 10.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EFA85500.1 - 0.0014 18.3 2.8 0.14 11.7 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EFA85500.1 - 0.0021 18.4 0.0 2.3 8.6 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Fer4_2 PF12797.7 EFA85500.1 - 0.0043 17.1 1.0 0.0043 17.1 1.0 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_28 PF13521.6 EFA85500.1 - 0.0044 17.3 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EFA85500.1 - 0.0045 17.5 2.8 0.18 12.3 0.3 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFA85500.1 - 0.0067 16.0 0.3 0.12 11.8 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Fer4_21 PF14697.6 EFA85500.1 - 0.0075 16.4 12.5 0.017 15.3 12.5 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_14 PF13173.6 EFA85500.1 - 0.0077 16.3 0.5 1.9 8.5 0.0 3.3 4 0 0 4 4 2 1 AAA domain TsaE PF02367.17 EFA85500.1 - 0.0092 16.0 0.2 0.21 11.6 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFA85500.1 - 0.011 16.3 0.0 7.7 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 EFA85500.1 - 0.025 15.5 0.3 0.025 15.5 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_30 PF13604.6 EFA85500.1 - 0.027 14.2 0.5 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_10 PF13237.6 EFA85500.1 - 0.027 14.6 1.7 0.027 14.6 1.7 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFA85500.1 - 0.034 14.3 12.9 0.075 13.2 12.9 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Zeta_toxin PF06414.12 EFA85500.1 - 0.037 13.3 0.4 0.81 8.9 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.23 EFA85500.1 - 0.043 13.9 0.1 7.2 6.7 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase VirE PF05272.11 EFA85500.1 - 0.06 13.1 0.0 8.5 6.0 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E TniB PF05621.11 EFA85500.1 - 0.063 12.7 0.0 3 7.2 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein Thymidylate_kin PF02223.17 EFA85500.1 - 0.12 12.0 1.7 11 5.6 0.0 2.9 4 0 0 4 4 2 0 Thymidylate kinase AAA_5 PF07728.14 EFA85500.1 - 0.16 12.0 0.6 8.7 6.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Fer4_7 PF12838.7 EFA85500.1 - 0.18 12.4 12.5 0.76 10.4 12.8 2.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain NB-ARC PF00931.22 EFA85500.1 - 0.19 10.9 0.5 16 4.6 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 EFA85500.1 - 1 9.2 3.8 15 5.4 0.0 3.1 3 0 0 3 3 2 0 NTPase Amidohydro_1 PF01979.20 EFA85501.1 - 5.5e-31 108.1 1.6 7.8e-31 107.6 1.6 1.2 1 0 0 1 1 1 1 Amidohydrolase family CDP-OH_P_transf PF01066.21 EFA85501.1 - 8.1e-14 52.1 0.1 8.1e-14 52.1 0.1 2.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Amidohydro_3 PF07969.11 EFA85501.1 - 2.6e-13 50.3 3.3 5.7e-07 29.4 0.0 2.6 2 1 1 3 3 3 2 Amidohydrolase family Amidohydro_2 PF04909.14 EFA85501.1 - 2.1e-06 27.7 0.1 3.2e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase AP_endonuc_2 PF01261.24 EFA85501.1 - 0.009 15.5 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Band_7_1 PF13421.6 EFA85501.1 - 0.0093 15.7 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 SPFH domain-Band 7 family TIG PF01833.24 EFA85502.1 - 1.5e-26 92.3 97.0 4.9e-11 42.6 5.6 12.7 12 1 0 12 12 12 5 IPT/TIG domain DNase_II PF03265.15 EFA85502.1 - 4.8e-24 85.3 5.4 1.8e-23 83.4 2.6 3.1 2 1 0 2 2 2 1 Deoxyribonuclease II SdrD_B PF17210.3 EFA85502.1 - 9.3e-10 38.7 1.5 2.3e-07 31.0 0.1 3.7 3 0 0 3 3 3 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA85502.1 - 1.5e-05 25.1 2.4 0.0023 18.2 0.0 3.7 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFA85502.1 - 0.018 15.0 0.1 0.089 12.8 0.1 2.2 1 0 0 1 1 1 0 CarboxypepD_reg-like domain SdrD_B PF17210.3 EFA85503.1 - 8.6e-06 26.0 0.1 2.2e-05 24.6 0.1 1.7 1 0 0 1 1 1 1 SdrD B-like domain PRKCSH_1 PF13015.6 EFA85503.1 - 3.4e-05 23.6 0.4 7.4e-05 22.5 0.4 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DUF3048_C PF17479.2 EFA85503.1 - 0.035 14.5 5.6 0.62 10.5 0.3 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain DCP1 PF06058.13 EFA85504.1 - 2.9e-37 127.2 0.2 5.8e-37 126.2 0.2 1.5 1 0 0 1 1 1 1 Dcp1-like decapping family Thioredoxin_8 PF13905.6 EFA85504.1 - 0.02 15.2 0.0 9.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like Voltage_CLC PF00654.20 EFA85505.1 - 7.6e-98 328.0 23.9 7.6e-98 328.0 23.9 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EFA85505.1 - 5.2e-11 42.8 0.1 7.6e-06 26.3 0.0 2.6 2 0 0 2 2 2 2 CBS domain TAT_signal PF10518.9 EFA85505.1 - 0.0009 19.0 2.4 0.0009 19.0 2.4 2.6 3 0 0 3 3 3 1 TAT (twin-arginine translocation) pathway signal sequence Abhydrolase_9_N PF15420.6 EFA85505.1 - 0.4 10.7 3.0 1.2 9.0 3.0 1.8 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus UCR_Fe-S_N PF10399.9 EFA85505.1 - 1.4 8.3 8.9 0.041 13.2 2.1 1.9 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DSPc PF00782.20 EFA85507.1 - 1.3e-10 41.2 0.4 1.4e-10 41.1 0.4 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFA85507.1 - 0.033 13.8 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFA85507.1 - 0.054 13.4 0.0 0.054 13.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 EFA85507.1 - 0.092 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PKD_channel PF08016.12 EFA85508.1 - 1.1e-25 90.3 17.3 2.6e-21 75.8 15.5 2.4 2 0 0 2 2 2 2 Polycystin cation channel TIG PF01833.24 EFA85509.1 - 3.2e-05 23.9 34.8 0.083 13.0 2.3 5.8 3 2 3 6 6 6 4 IPT/TIG domain TMEM154 PF15102.6 EFA85509.1 - 6.3 6.7 8.0 15 5.4 8.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family FNIP PF05725.12 EFA85512.1 - 9.8e-69 227.3 41.2 4.6e-13 49.1 3.5 9.6 9 1 0 9 9 9 8 FNIP Repeat DnaJ PF00226.31 EFA85512.1 - 5e-19 68.2 0.8 9.8e-19 67.3 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain LRR_8 PF13855.6 EFA85512.1 - 0.072 12.9 2.6 0.26 11.1 0.2 3.3 2 1 1 3 3 3 0 Leucine rich repeat Atx10homo_assoc PF09759.9 EFA85513.1 - 2.9e-08 33.6 6.5 1.2e-05 25.2 0.3 4.5 2 2 2 4 4 4 2 Spinocerebellar ataxia type 10 protein domain F-box-like PF12937.7 EFA85513.1 - 6.4e-05 22.8 0.7 6.4e-05 22.8 0.7 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA85513.1 - 0.00013 21.7 3.6 0.00036 20.3 1.3 2.6 2 0 0 2 2 2 1 F-box domain DUF3361 PF11841.8 EFA85513.1 - 0.027 14.4 13.2 0.072 13.0 2.2 3.8 1 1 2 3 3 3 0 Domain of unknown function (DUF3361) Ala_racemase_N PF01168.20 EFA85514.1 - 4.8e-20 72.1 0.0 6e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 EFA85514.1 - 1.2e-05 25.9 0.2 4.5e-05 24.0 0.0 2.2 2 1 0 2 2 2 1 Putative serine dehydratase domain AAA_23 PF13476.6 EFA85515.1 - 3.2e-32 112.7 1.7 3.2e-32 112.7 1.7 8.1 1 1 4 6 6 6 1 AAA domain AAA_21 PF13304.6 EFA85515.1 - 4.2e-12 46.5 0.2 2.2e-05 24.4 0.1 3.5 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFA85515.1 - 6e-06 26.2 6.3 6e-06 26.2 6.3 5.7 1 1 3 4 4 4 1 AAA ATPase domain SMC_N PF02463.19 EFA85515.1 - 4.8e-05 22.9 48.7 0.00023 20.7 48.7 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EFA85515.1 - 0.00077 19.7 0.0 0.002 18.3 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Rad50_zn_hook PF04423.14 EFA85515.1 - 0.00091 19.0 0.7 0.00091 19.0 0.7 5.0 6 0 0 6 6 6 1 Rad50 zinc hook motif AAA_13 PF13166.6 EFA85515.1 - 0.0041 15.9 121.2 0.0075 15.0 0.0 7.2 1 1 4 7 7 7 4 AAA domain ABC_tran PF00005.27 EFA85515.1 - 0.011 16.3 0.1 0.011 16.3 0.1 7.5 1 1 2 4 4 4 0 ABC transporter AAA_29 PF13555.6 EFA85515.1 - 0.013 15.2 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA85515.1 - 0.34 11.3 8.1 0.4 11.0 0.0 4.4 4 1 0 4 4 4 0 AAA ATPase domain Herpes_pp85 PF04637.12 EFA85516.1 - 0.014 13.9 0.6 0.015 13.7 0.6 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) BDV_P24 PF06595.11 EFA85516.1 - 0.095 12.6 1.0 0.13 12.1 1.0 1.2 1 0 0 1 1 1 0 Borna disease virus P24 protein PRKCSH PF07915.13 EFA85517.1 - 2.6e-16 60.4 12.4 5e-16 59.5 2.0 3.6 2 2 0 2 2 2 1 Glucosidase II beta subunit-like protein CemA PF03040.14 EFA85517.1 - 0.094 12.6 1.8 0.16 11.9 1.8 1.3 1 0 0 1 1 1 0 CemA family SR-25 PF10500.9 EFA85517.1 - 0.22 11.1 10.6 0.053 13.1 4.3 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Pex14_N PF04695.13 EFA85517.1 - 1.6 9.3 15.4 4.5 7.9 6.3 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HlyD PF00529.20 EFA85517.1 - 1.7 8.6 5.7 0.27 11.1 0.7 2.2 2 1 1 3 3 3 0 HlyD membrane-fusion protein of T1SS Presenilin PF01080.17 EFA85517.1 - 1.8 7.2 9.5 1.7 7.3 2.5 2.0 2 0 0 2 2 2 0 Presenilin EBP50_C PF09007.11 EFA85517.1 - 1.9 9.5 13.1 1.3 10.1 3.4 2.3 2 0 0 2 2 2 0 EBP50, C-terminal Zip PF02535.22 EFA85517.1 - 3.4 6.8 6.0 9.8 5.3 0.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter SSP160 PF06933.11 EFA85517.1 - 5.2 5.1 12.6 7.6 4.6 12.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 IMUP PF15761.5 EFA85517.1 - 5.3 7.8 13.2 0.4 11.4 5.1 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein vATP-synt_E PF01991.18 EFA85518.1 - 1.6e-69 233.3 4.6 1.9e-69 233.1 4.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit RapH_N PF18801.1 EFA85518.1 - 9.9 6.3 7.9 11 6.1 0.3 2.9 3 0 0 3 3 3 0 response regulator aspartate phosphatase H, N terminal DUF3430 PF11912.8 EFA85520.1 - 0.0091 16.1 29.1 0.69 9.9 24.5 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3430) DUF2428 PF10350.9 EFA85521.1 - 1.6e-79 267.0 0.0 1.1e-78 264.3 0.0 2.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EFA85521.1 - 0.00033 20.7 0.7 0.98 9.9 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat SUIM_assoc PF16619.5 EFA85521.1 - 0.0099 15.9 0.6 0.089 12.9 0.6 2.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 K_channel_TID PF07941.11 EFA85521.1 - 0.53 10.8 0.0 0.53 10.8 0.0 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain HIRA_B PF09453.10 EFA85522.1 - 0.024 14.5 0.4 0.055 13.3 0.4 1.7 1 0 0 1 1 1 0 HIRA B motif FSA_C PF10479.9 EFA85524.1 - 0.33 9.0 5.8 0.28 9.2 5.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PRKCSH_1 PF13015.6 EFA85526.1 - 0.00015 21.5 0.1 0.0011 18.7 0.0 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein VIT PF08487.10 EFA85527.1 - 3.8e-25 88.3 1.3 3.8e-25 88.3 1.3 2.5 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain IBB PF01749.20 EFA85527.1 - 3.6e-09 36.9 1.4 3.6e-09 36.9 1.4 2.9 3 0 0 3 3 3 1 Importin beta binding domain KGK PF08872.10 EFA85528.1 - 0.068 13.7 0.4 0.068 13.7 0.4 2.1 2 0 0 2 2 2 0 KGK domain Mucin PF01456.17 EFA85528.1 - 0.49 10.4 9.7 1 9.3 9.7 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Tir_receptor_C PF07489.11 EFA85528.1 - 0.78 9.7 13.2 0.089 12.8 8.8 1.7 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus DNase_II PF03265.15 EFA85529.1 - 9.4e-05 21.8 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Deoxyribonuclease II Chalcone PF02431.15 EFA85529.1 - 0.18 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Chalcone-flavanone isomerase FNIP PF05725.12 EFA85530.1 - 4.7e-18 65.1 24.3 1e-08 35.2 0.2 9.2 5 2 4 9 9 9 6 FNIP Repeat F-box_5 PF18511.1 EFA85530.1 - 4.8e-06 26.0 0.1 0.055 13.1 0.0 3.6 3 0 0 3 3 3 2 F-box F-box-like PF12937.7 EFA85530.1 - 0.00035 20.4 8.2 0.22 11.5 0.1 3.6 3 0 0 3 3 3 3 F-box-like F-box PF00646.33 EFA85530.1 - 0.013 15.4 6.6 0.099 12.6 0.2 3.8 3 0 0 3 3 3 0 F-box domain FNIP PF05725.12 EFA85531.1 - 4e-23 81.3 18.8 2.2e-12 46.9 0.2 6.4 7 1 0 7 7 7 4 FNIP Repeat F-box PF00646.33 EFA85531.1 - 0.00025 20.8 0.6 0.00074 19.3 0.1 2.1 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 EFA85531.1 - 0.0066 16.0 0.1 0.013 15.1 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA85531.1 - 0.0099 15.8 0.3 0.022 14.6 0.3 1.6 1 0 0 1 1 1 1 F-box-like CENP-T_C PF15511.6 EFA85533.1 - 1.6e-08 34.6 0.0 2e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EFA85533.1 - 3.7e-05 23.8 0.0 5.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFA85533.1 - 0.00021 21.5 0.0 0.00034 20.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFA85533.1 - 0.0007 19.9 0.2 0.00094 19.5 0.2 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EFA85533.1 - 0.001 19.4 0.2 0.0012 19.2 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EFA85533.1 - 0.0023 18.0 0.0 0.0028 17.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFA85533.1 - 0.0061 16.6 0.1 0.011 15.7 0.1 1.5 1 1 1 2 2 2 1 Bromodomain associated RSN1_7TM PF02714.15 EFA85535.1 - 2.3e-79 266.5 27.4 2.3e-79 266.5 27.4 2.5 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFA85535.1 - 3.7e-41 140.5 4.2 3.7e-41 140.5 4.2 2.8 2 1 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFA85535.1 - 9.4e-31 107.4 0.0 1.4e-30 106.8 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Kinesin PF00225.23 EFA85536.1 - 3.8e-57 193.7 0.7 3.8e-57 193.7 0.7 3.6 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EFA85536.1 - 2e-16 60.2 0.0 2e-16 60.2 0.0 4.0 4 1 0 4 4 4 2 Microtubule binding AAA_22 PF13401.6 EFA85536.1 - 0.15 12.3 1.9 1 9.6 0.0 3.1 2 0 0 2 2 2 0 AAA domain zf-RING_2 PF13639.6 EFA85537.1 - 4e-11 43.1 5.5 8.5e-11 42.0 5.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFA85537.1 - 1.2e-08 34.6 5.7 3.5e-08 33.2 5.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA85537.1 - 5.7e-08 32.9 2.8 1.5e-07 31.6 2.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFA85537.1 - 7.2e-08 32.0 1.8 7.2e-08 32.0 1.8 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 EFA85537.1 - 1.5e-07 31.3 2.9 2.5e-07 30.5 2.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFA85537.1 - 3e-07 30.2 3.2 6.5e-07 29.1 3.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA85537.1 - 1e-06 28.5 5.8 1.9e-06 27.6 5.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA85537.1 - 2e-06 27.6 3.7 1e-05 25.3 3.5 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFA85537.1 - 8e-05 22.6 1.5 0.00027 20.9 1.5 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFA85537.1 - 0.00025 21.0 2.8 0.00034 20.6 1.6 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 EFA85537.1 - 0.0017 18.1 5.8 0.0038 17.0 5.8 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EFA85537.1 - 0.006 16.2 3.4 0.011 15.4 3.4 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EFA85537.1 - 0.06 13.5 5.2 0.13 12.4 5.2 1.6 1 0 0 1 1 1 0 RING-variant domain EIF_2_alpha PF07541.12 EFA85538.1 - 3.7e-35 120.5 0.0 6.7e-35 119.7 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EFA85538.1 - 2.8e-14 53.2 1.8 6e-14 52.1 1.8 1.6 1 0 0 1 1 1 1 S1 RNA binding domain ATP-synt_F PF01990.17 EFA85541.1 - 8.7e-32 109.3 0.4 1.1e-31 109.0 0.4 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit LPAM_2 PF13627.6 EFA85541.1 - 0.0095 15.8 0.7 0.016 15.0 0.7 1.4 1 0 0 1 1 1 1 Prokaryotic lipoprotein-attachment site DXP_synthase_N PF13292.6 EFA85541.1 - 0.01 15.1 0.1 0.01 15.1 0.1 1.1 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Proteasome PF00227.26 EFA85542.1 - 1.1e-33 116.4 0.0 1.3e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Endonuclease_5 PF04493.14 EFA85543.1 - 5.9e-68 228.5 0.0 7.7e-68 228.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.16 EFA85543.1 - 0.0044 16.5 0.0 0.0087 15.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF99 SSP160 PF06933.11 EFA85543.1 - 0.21 9.8 1.7 0.28 9.3 1.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Golgin_A5 PF09787.9 EFA85543.1 - 1.7 8.0 6.0 2.4 7.5 6.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 SDA1 PF05285.12 EFA85543.1 - 2.3 7.6 12.8 3.1 7.1 12.8 1.1 1 0 0 1 1 1 0 SDA1 Tub_N PF16322.5 EFA85543.1 - 2.4 8.5 7.4 4 7.8 7.4 1.2 1 0 0 1 1 1 0 Tubby N-terminal PI3K_1B_p101 PF10486.9 EFA85543.1 - 6.1 4.5 5.9 8.1 4.1 5.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TIG PF01833.24 EFA85544.1 - 2.5e-26 91.5 70.5 6.6e-11 42.1 7.1 10.5 10 0 0 10 10 10 5 IPT/TIG domain DNase_II PF03265.15 EFA85544.1 - 4.9e-26 91.8 7.7 4.9e-26 91.8 7.7 2.8 2 1 0 2 2 2 1 Deoxyribonuclease II SdrD_B PF17210.3 EFA85544.1 - 7.8e-10 39.0 14.2 2.4e-09 37.4 5.2 4.4 5 0 0 5 5 5 1 SdrD B-like domain MetallophosN PF16371.5 EFA85544.1 - 0.015 15.5 0.3 0.089 13.1 0.3 2.3 1 0 0 1 1 1 0 N terminal of Calcineurin-like phosphoesterase CarboxypepD_reg PF13620.6 EFA85544.1 - 0.031 14.5 4.8 0.049 13.9 2.0 3.1 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain DUF725 PF05267.12 EFA85544.1 - 0.18 11.8 1.9 21 5.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF725) CarbopepD_reg_2 PF13715.6 EFA85544.1 - 1.3 9.0 6.0 0.91 9.6 1.6 3.1 3 0 0 3 3 3 0 CarboxypepD_reg-like domain Glyoxalase PF00903.25 EFA85545.1 - 5.4e-08 33.1 0.0 1.6e-06 28.3 0.0 2.6 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFA85545.1 - 0.034 14.2 0.0 15 5.6 0.0 3.0 3 0 0 3 3 3 0 Glyoxalase-like domain Glyoxalase_4 PF13669.6 EFA85545.1 - 0.14 12.5 0.0 0.83 10.0 0.0 2.3 2 1 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AF-4 PF05110.13 EFA85545.1 - 0.15 10.1 4.3 0.22 9.6 4.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Cofilin_ADF PF00241.20 EFA85546.1 - 5.5e-17 61.7 0.0 1.3e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 EFA85546.1 - 7e-16 57.6 0.3 1.8e-15 56.3 0.3 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA85546.1 - 2.2e-15 56.3 1.0 3e-15 55.8 0.3 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EFA85546.1 - 3.7e-14 52.1 0.1 1.6e-13 50.1 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain GDI PF00996.18 EFA85547.1 - 7.3e-57 192.8 7.1 5.2e-43 147.2 3.7 2.8 2 1 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EFA85547.1 - 0.044 14.0 0.0 0.089 13.0 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain E1_dh PF00676.20 EFA85549.1 - 1.7e-97 326.0 0.1 2.1e-97 325.7 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EFA85549.1 - 0.0022 17.2 0.1 0.016 14.4 0.0 2.3 3 0 0 3 3 3 1 1-deoxy-D-xylulose-5-phosphate synthase DUF1870 PF08965.10 EFA85549.1 - 1 9.4 4.9 4.6 7.3 0.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1870) WD40 PF00400.32 EFA85550.1 - 7.2e-11 42.5 16.2 0.02 15.8 1.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat SR-25 PF10500.9 EFA85550.1 - 1.4 8.5 19.3 1.5 8.4 13.0 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein CBP_GIL PF10995.8 EFA85551.1 - 0.033 12.9 0.2 0.036 12.7 0.2 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis GIL Alpha_kinase PF02816.18 EFA85552.1 - 7.5e-55 185.9 1.3 1.4e-54 185.0 0.2 2.0 2 0 0 2 2 2 1 Alpha-kinase family WD40 PF00400.32 EFA85552.1 - 1.8e-39 133.0 17.8 4.3e-07 30.5 0.1 7.9 8 0 0 8 8 7 7 WD domain, G-beta repeat Nup160 PF11715.8 EFA85552.1 - 2e-16 59.8 5.5 0.004 15.9 0.0 5.5 1 1 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFA85552.1 - 1.5e-07 31.6 5.1 0.19 12.1 0.4 4.8 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA85552.1 - 9.2e-07 28.5 6.3 0.0066 15.8 0.4 2.3 1 1 1 2 2 2 2 WD40-like domain Nucleoporin_N PF08801.11 EFA85552.1 - 1.3e-05 24.2 16.2 0.013 14.3 0.7 4.9 3 1 0 4 4 4 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 EFA85552.1 - 0.0053 15.3 0.8 0.39 9.2 0.1 3.1 2 1 1 3 3 3 1 Cytochrome D1 heme domain PspA_IM30 PF04012.12 EFA85552.1 - 0.0096 15.5 1.4 0.015 14.9 1.4 1.2 1 0 0 1 1 1 1 PspA/IM30 family Tropomyosin_1 PF12718.7 EFA85552.1 - 0.01 16.0 0.5 0.01 16.0 0.5 1.7 2 0 0 2 2 2 0 Tropomyosin like DUF3450 PF11932.8 EFA85552.1 - 0.015 14.6 3.6 0.032 13.5 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PQQ_3 PF13570.6 EFA85552.1 - 0.071 13.6 0.0 1.4e+02 3.2 0.0 4.3 4 0 0 4 4 4 0 PQQ-like domain DASH_Dad1 PF08649.10 EFA85552.1 - 0.097 12.9 0.6 0.28 11.4 0.6 1.8 1 0 0 1 1 1 0 DASH complex subunit Dad1 LVIVD PF08309.11 EFA85552.1 - 0.2 11.0 2.9 4.4 6.7 0.0 3.4 4 0 0 4 4 4 0 LVIVD repeat Baculo_PEP_C PF04513.12 EFA85552.1 - 0.25 11.4 4.5 0.57 10.2 4.5 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2570 PF10828.8 EFA85552.1 - 2 8.3 5.9 0.47 10.3 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) NPV_P10 PF05531.12 EFA85552.1 - 3 8.4 9.3 0.49 10.9 3.7 2.5 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein DNase_II PF03265.15 EFA85554.1 - 1.1e-20 74.2 10.3 2.3e-10 40.3 3.7 3.3 2 2 1 3 3 3 2 Deoxyribonuclease II DUF3447 PF11929.8 EFA85554.1 - 0.35 10.8 4.7 0.28 11.1 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF3447) Rad51 PF08423.11 EFA85555.1 - 1.4e-44 152.3 0.9 5e-22 78.4 0.1 2.3 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 EFA85555.1 - 2.9e-13 49.8 0.0 1.1e-12 48.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 EFA85555.1 - 4.9e-08 32.6 0.1 2.2e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 KaiC RecA PF00154.21 EFA85555.1 - 0.0015 18.1 0.1 0.018 14.5 0.0 2.2 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 EFA85555.1 - 0.0036 17.1 7.3 0.0094 15.7 0.0 3.3 2 2 1 3 3 3 1 AAA domain TMEM51 PF15345.6 EFA85555.1 - 0.06 13.2 5.9 0.15 11.8 5.9 1.7 1 0 0 1 1 1 0 Transmembrane protein 51 Presenilin PF01080.17 EFA85555.1 - 0.16 10.7 6.2 0.26 10.0 6.2 1.2 1 0 0 1 1 1 0 Presenilin AAA_33 PF13671.6 EFA85555.1 - 0.18 11.9 0.1 0.18 11.9 0.1 2.9 3 1 0 3 3 3 0 AAA domain DUF1360 PF07098.11 EFA85555.1 - 0.2 11.6 0.9 0.91 9.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) MFS_Mycoplasma PF07672.13 EFA85555.1 - 0.46 9.7 5.8 0.66 9.2 4.3 1.9 2 0 0 2 2 2 0 Mycoplasma MFS transporter AAA_18 PF13238.6 EFA85555.1 - 1.3 9.6 9.0 0.37 11.3 0.3 3.9 1 1 2 3 3 3 0 AAA domain EphA2_TM PF14575.6 EFA85555.1 - 1.4 9.8 10.6 0.07 14.0 3.7 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PBP1_TM PF14812.6 EFA85555.1 - 2.2 8.7 7.1 0.36 11.2 0.2 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4175 PF13779.6 EFA85555.1 - 3.8 5.3 19.2 5.3 4.8 19.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RNase_H2_suC PF08615.11 EFA85555.1 - 6.2 7.0 13.9 8.9e+02 -0.0 0.0 3.0 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PP2C PF00481.21 EFA85556.1 - 5.7e-24 85.1 8.0 1.2e-20 74.3 0.0 3.2 3 1 1 4 4 4 2 Protein phosphatase 2C Sugarporin_N PF11471.8 EFA85556.1 - 0.015 15.3 0.6 0.043 13.8 0.6 1.8 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension EF_assoc_2 PF08356.12 EFA85557.1 - 1.2e-23 82.9 0.0 1.1e-22 79.8 0.0 2.6 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 EFA85557.1 - 1.7e-20 73.3 0.2 7.1e-14 51.7 0.1 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFA85557.1 - 2.6e-14 53.5 0.1 9.1e-09 35.6 0.0 3.6 2 2 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFA85557.1 - 2.8e-09 37.0 0.0 0.0028 17.7 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.6 EFA85557.1 - 6.7e-09 36.1 0.6 0.0053 17.2 0.1 2.9 3 0 0 3 3 2 2 EF-hand domain pair EF_assoc_1 PF08355.12 EFA85557.1 - 2.1e-08 33.6 0.0 4.7e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 EF hand associated Arf PF00025.21 EFA85557.1 - 5.5e-08 32.5 0.9 0.00074 19.0 0.3 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family EF-hand_1 PF00036.32 EFA85557.1 - 7.4e-08 31.4 1.0 0.013 15.0 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFA85557.1 - 8.3e-08 31.6 0.6 0.0041 17.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain RsgA_GTPase PF03193.16 EFA85557.1 - 1.3e-07 31.7 3.6 0.0085 16.0 0.0 3.5 2 1 1 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 EFA85557.1 - 5.3e-07 29.4 6.2 0.0004 20.0 0.1 3.7 4 0 0 4 4 4 2 Elongation factor Tu GTP binding domain Septin PF00735.18 EFA85557.1 - 3.4e-06 26.6 0.1 0.42 9.8 0.0 3.4 3 0 0 3 3 3 2 Septin Dynamin_N PF00350.23 EFA85557.1 - 1.5e-05 25.1 2.3 0.016 15.3 0.4 2.8 2 1 0 2 2 2 2 Dynamin family EF-hand_10 PF14788.6 EFA85557.1 - 2.6e-05 24.0 0.5 0.053 13.4 0.0 3.0 2 0 0 2 2 2 2 EF hand ABC_tran PF00005.27 EFA85557.1 - 3.9e-05 24.2 0.1 0.41 11.2 0.0 3.2 3 0 0 3 3 3 2 ABC transporter AAA_29 PF13555.6 EFA85557.1 - 5.6e-05 22.8 0.3 0.33 10.7 0.1 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA85557.1 - 6.7e-05 23.3 0.4 0.41 11.0 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain EF-hand_8 PF13833.6 EFA85557.1 - 0.00017 21.4 2.6 0.13 12.1 0.1 2.9 2 1 1 3 3 2 2 EF-hand domain pair AAA_7 PF12775.7 EFA85557.1 - 0.00046 19.8 0.1 0.052 13.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region FeoB_N PF02421.18 EFA85557.1 - 0.00052 19.6 0.6 6.1 6.3 0.1 3.3 3 0 0 3 3 3 0 Ferrous iron transport protein B EF-hand_5 PF13202.6 EFA85557.1 - 0.0012 18.3 5.0 0.017 14.6 0.8 2.7 2 0 0 2 2 2 1 EF hand RNA_helicase PF00910.22 EFA85557.1 - 0.0015 18.8 1.1 4.1 7.9 0.0 3.7 4 0 0 4 4 3 0 RNA helicase AAA_22 PF13401.6 EFA85557.1 - 0.0024 18.1 0.5 18 5.6 0.0 3.7 3 1 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 EFA85557.1 - 0.0029 17.4 1.9 10 5.8 0.1 3.6 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EFA85557.1 - 0.003 17.8 0.2 1.1 9.5 0.1 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFA85557.1 - 0.0062 15.8 0.2 0.29 10.3 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain FtsK_SpoIIIE PF01580.18 EFA85557.1 - 0.0078 15.6 0.1 0.028 13.8 0.1 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family DUF815 PF05673.13 EFA85557.1 - 0.01 15.1 0.0 1.9 7.5 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EFA85557.1 - 0.011 16.3 0.0 7.9 7.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 EFA85557.1 - 0.011 14.8 4.3 0.0078 15.4 1.9 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein MMR_HSR1_Xtn PF16897.5 EFA85557.1 - 0.015 15.3 0.2 0.046 13.7 0.2 1.9 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DAP3 PF10236.9 EFA85557.1 - 0.015 14.5 0.1 0.81 8.8 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 EFA85557.1 - 0.015 15.2 0.4 12 5.8 0.0 3.8 5 0 0 5 5 3 0 NACHT domain AAA_32 PF13654.6 EFA85557.1 - 0.016 14.0 0.0 0.055 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFA85557.1 - 0.017 15.3 0.0 1.8 8.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFA85557.1 - 0.019 14.1 7.1 0.84 8.7 3.9 3.3 2 2 0 2 2 2 0 G-protein alpha subunit Pox_A32 PF04665.12 EFA85557.1 - 0.022 14.2 0.1 2.4 7.6 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein HobA PF12163.8 EFA85557.1 - 0.031 13.8 1.8 0.12 12.0 0.1 2.5 3 0 0 3 3 2 0 DNA replication regulator PduV-EutP PF10662.9 EFA85557.1 - 0.036 13.8 0.2 15 5.3 0.1 3.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 EFA85557.1 - 0.044 13.8 0.5 0.99 9.5 0.0 2.9 3 1 1 4 4 3 0 AAA domain Ploopntkinase3 PF18751.1 EFA85557.1 - 0.052 13.4 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Viral_helicase1 PF01443.18 EFA85557.1 - 0.053 13.3 2.1 5.6 6.6 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EFA85557.1 - 0.061 13.0 0.1 4.8 6.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain PGAP1 PF07819.13 EFA85557.1 - 0.065 12.9 0.2 0.17 11.6 0.2 1.7 1 0 0 1 1 1 0 PGAP1-like protein MCM PF00493.23 EFA85557.1 - 0.068 12.2 1.5 0.63 9.1 0.0 2.8 3 1 0 3 3 3 0 MCM P-loop domain SPARC_Ca_bdg PF10591.9 EFA85557.1 - 0.078 13.3 4.6 4.9 7.5 0.0 3.5 4 0 0 4 4 3 0 Secreted protein acidic and rich in cysteine Ca binding region CLP1_P PF16575.5 EFA85557.1 - 0.094 12.5 0.3 26 4.5 0.0 3.3 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DND1_DSRM PF14709.7 EFA85557.1 - 0.13 12.5 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_18 PF13238.6 EFA85558.1 - 7.1e-06 26.6 0.1 1.8e-05 25.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EFA85558.1 - 0.00016 21.0 0.0 0.00033 20.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 EFA85558.1 - 0.0013 18.9 0.0 0.0031 17.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFA85558.1 - 0.0017 18.6 0.0 0.0029 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFA85558.1 - 0.0096 16.3 0.2 0.082 13.3 0.2 2.6 1 1 0 1 1 1 1 RNA helicase Rad17 PF03215.15 EFA85558.1 - 0.025 14.5 0.3 0.089 12.7 0.2 1.9 1 1 1 2 2 2 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EFA85558.1 - 0.026 14.5 0.1 0.072 13.0 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EFA85558.1 - 0.045 14.3 1.5 0.13 12.8 1.5 1.9 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFA85558.1 - 0.051 14.0 0.0 0.092 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 EFA85558.1 - 0.07 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 EFA85558.1 - 0.14 12.5 0.1 0.38 11.2 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFA85558.1 - 0.17 11.7 0.2 0.37 10.5 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EFA85558.1 - 0.19 11.7 0.1 0.43 10.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Cytidylate_kin PF02224.18 EFA85558.1 - 0.22 11.2 0.2 0.6 9.8 0.1 1.5 1 1 1 2 2 2 0 Cytidylate kinase AAA_25 PF13481.6 EFA85558.1 - 0.3 10.7 0.7 0.52 9.9 0.7 1.3 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 EFA85558.1 - 0.4 10.8 1.2 1 9.4 1.2 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain EF-1_beta_acid PF10587.9 EFA85559.1 - 0.05 14.1 0.3 0.05 14.1 0.3 2.4 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region G8 PF10162.9 EFA85560.1 - 3.1e-25 88.6 0.2 1.3e-24 86.6 0.2 2.1 1 0 0 1 1 1 1 G8 domain Mre11_DNA_bind PF04152.14 EFA85561.1 - 4.9e-34 118.1 0.0 4.9e-34 118.1 0.0 2.4 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain FNIP PF05725.12 EFA85562.1 - 1.1e-18 67.1 22.7 1.5e-12 47.4 0.0 7.3 9 0 0 9 9 9 3 FNIP Repeat F-box_5 PF18511.1 EFA85562.1 - 0.0012 18.3 0.2 0.0025 17.4 0.2 1.4 1 0 0 1 1 1 1 F-box PIG-S PF10510.9 EFA85563.1 - 3.2e-99 333.1 7.1 1.1e-91 308.2 4.6 2.0 2 0 0 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein Vpu PF00558.19 EFA85563.1 - 0.018 14.8 1.2 0.073 12.9 0.0 2.4 2 0 0 2 2 2 0 Vpu protein SNARE PF05739.19 EFA85563.1 - 0.4 10.7 12.1 0.42 10.7 0.8 3.0 3 0 0 3 3 3 0 SNARE domain DDE_Tnp_4 PF13359.6 EFA85564.1 - 5.6e-22 78.1 0.6 2e-21 76.3 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease Retrotrans_gag PF03732.17 EFA85564.1 - 0.0012 19.1 0.1 0.0032 17.7 0.1 1.8 1 0 0 1 1 1 1 Retrotransposon gag protein Afi1 PF07792.12 EFA85567.1 - 0.0018 18.7 5.2 0.0032 18.0 5.2 1.3 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_Rpc4 PF05132.14 EFA85567.1 - 0.018 15.5 4.1 0.029 14.8 4.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 SID-1_RNA_chan PF13965.6 EFA85567.1 - 0.05 12.0 1.1 0.064 11.7 1.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_U57 PF05582.12 EFA85567.1 - 0.11 11.8 3.3 0.15 11.3 3.3 1.1 1 0 0 1 1 1 0 YabG peptidase U57 GCD14 PF08704.10 EFA85567.1 - 0.18 11.4 3.0 0.3 10.7 3.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Spt20 PF12090.8 EFA85567.1 - 0.26 10.9 16.1 0.029 14.0 11.6 1.6 2 0 0 2 2 2 0 Spt20 family FAM76 PF16046.5 EFA85567.1 - 0.31 10.3 8.2 0.46 9.8 8.2 1.2 1 0 0 1 1 1 0 FAM76 protein Itfg2 PF15907.5 EFA85567.1 - 0.73 8.8 10.9 1.2e+02 1.5 10.0 2.8 1 1 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 Zip PF02535.22 EFA85567.1 - 0.9 8.7 2.9 1 8.5 2.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 EFA85567.1 - 2.6 6.8 5.6 3.3 6.4 5.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TIG PF01833.24 EFA85570.1 - 4.4e-80 263.8 96.1 1.6e-12 47.3 5.9 13.3 12 1 0 12 12 12 11 IPT/TIG domain SseC PF04888.12 EFA85570.1 - 0.021 14.4 1.5 0.034 13.7 1.5 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family CENP-B_dimeris PF09026.10 EFA85570.1 - 5.6 7.4 6.7 11 6.5 6.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TIG PF01833.24 EFA85571.1 - 1.7e-49 165.8 158.3 4.3e-11 42.7 5.5 16.9 16 0 0 16 16 16 12 IPT/TIG domain DNase_II PF03265.15 EFA85571.1 - 5.7e-25 88.3 1.3 5.7e-25 88.3 1.3 3.5 3 1 0 3 3 3 1 Deoxyribonuclease II SdrD_B PF17210.3 EFA85571.1 - 4.7e-09 36.5 5.5 4.1e-08 33.4 0.1 4.0 4 0 0 4 4 4 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA85571.1 - 1.1e-05 25.6 4.4 0.00029 21.0 0.0 3.9 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFA85571.1 - 0.015 15.3 0.1 0.068 13.2 0.1 2.1 1 0 0 1 1 1 0 CarboxypepD_reg-like domain PRKCSH_1 PF13015.6 EFA85572.1 - 2e-16 60.1 9.4 0.00012 21.8 0.6 4.4 4 0 0 4 4 4 3 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA85572.1 - 1.8e-07 31.4 20.9 0.0016 18.5 0.3 5.7 5 1 0 5 5 5 4 Cation-independent mannose-6-phosphate receptor repeat SdrD_B PF17210.3 EFA85572.1 - 7.3e-07 29.4 6.0 2.6e-06 27.6 0.3 3.2 3 0 0 3 3 3 1 SdrD B-like domain DUF3048_C PF17479.2 EFA85572.1 - 0.0004 20.8 11.7 0.008 16.6 0.2 3.7 5 0 0 5 5 5 2 Protein of unknown function (DUF3048) C-terminal domain Agenet PF05641.12 EFA85574.1 - 0.0004 20.8 0.2 0.0015 19.0 0.0 2.0 2 0 0 2 2 2 1 Agenet domain PBP1_TM PF14812.6 EFA85574.1 - 9.2 6.7 7.3 14 6.1 2.9 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-LYAR PF08790.11 EFA85575.1 - 0.067 13.1 6.1 0.15 12.0 6.1 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger NPR1_interact PF15699.5 EFA85577.1 - 0.23 12.1 6.4 0.063 13.9 2.7 1.8 2 0 0 2 2 2 0 NPR1 interacting ABC_tran_CTD PF16326.5 EFA85579.1 - 0.023 14.9 0.5 0.04 14.2 0.3 1.5 1 1 0 1 1 1 0 ABC transporter C-terminal domain PGBA_N PF15436.6 EFA85580.1 - 0.025 14.2 0.1 0.045 13.4 0.1 1.5 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA N-terminal Methyltransf_18 PF12847.7 EFA85582.1 - 0.18 11.8 1.2 0.89 9.5 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain DUF641 PF04859.12 EFA85582.1 - 0.97 9.8 5.2 0.44 10.9 1.2 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) TMF_DNA_bd PF12329.8 EFA85582.1 - 2.6 8.1 8.8 0.28 11.2 4.0 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Mucin PF01456.17 EFA85582.1 - 4.6 7.2 23.3 0.2 11.6 16.5 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein Retrotrans_gag PF03732.17 EFA85583.1 - 0.0014 18.9 0.4 0.0028 17.9 0.4 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein RT_RNaseH PF17917.1 EFA85584.1 - 3.2e-23 82.0 0.2 7.8e-23 80.8 0.2 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EFA85584.1 - 6.1e-23 81.5 0.4 1.8e-22 80.0 0.4 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EFA85584.1 - 1.7e-22 79.3 0.1 4e-22 78.1 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EFA85584.1 - 6.6e-17 61.4 0.2 6.6e-17 61.4 0.2 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EFA85584.1 - 7.5e-12 45.5 0.0 1.6e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RSN1_7TM PF02714.15 EFA85584.1 - 0.0013 18.1 3.1 0.002 17.5 3.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate zf-H2C2 PF09337.10 EFA85584.1 - 0.0037 17.4 1.6 0.0069 16.6 0.3 2.3 2 0 0 2 2 2 1 H2C2 zinc finger DUF5347 PF17282.2 EFA85584.1 - 0.038 14.3 1.8 3.9 7.8 0.0 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5347) TFIIA PF03153.13 EFA85585.1 - 0.0024 17.9 14.1 0.0032 17.5 14.1 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit fn3_3 PF14686.6 EFA85585.1 - 0.11 12.4 0.9 0.23 11.3 0.9 1.6 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II WBP-1 PF11669.8 EFA85585.1 - 0.12 13.0 0.6 0.63 10.7 0.6 2.2 1 0 0 1 1 1 0 WW domain-binding protein 1 Ndc1_Nup PF09531.10 EFA85585.1 - 0.17 10.6 2.7 0.21 10.3 2.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HLH PF00010.26 EFA85585.1 - 0.25 11.3 4.0 0.14 12.2 0.8 2.3 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Presenilin PF01080.17 EFA85585.1 - 2.9 6.6 9.3 4.8 5.8 9.3 1.4 1 0 0 1 1 1 0 Presenilin NADH_dhqG_C PF09326.11 EFA85585.1 - 2.9 8.6 6.3 0.37 11.5 0.2 2.6 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal Cornifin PF02389.15 EFA85586.1 - 0.00019 21.6 11.6 0.00034 20.8 11.6 1.3 1 0 0 1 1 1 1 Cornifin (SPRR) family PfUIS3 PF11567.8 EFA85586.1 - 0.48 10.8 3.7 0.28 11.6 1.4 1.9 2 0 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein PBP1_TM PF14812.6 EFA85587.1 - 2.8 8.4 8.2 0.48 10.8 3.6 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Agenet PF05641.12 EFA85589.1 - 0.01 16.3 0.0 0.02 15.4 0.0 1.4 1 0 0 1 1 1 0 Agenet domain LBR_tudor PF09465.10 EFA85589.1 - 0.058 13.2 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Spb1_C PF07780.12 EFA85591.1 - 4.5e-61 206.2 31.2 4.5e-61 206.2 31.2 3.3 3 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EFA85591.1 - 4.9e-54 183.1 0.0 1e-53 182.1 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EFA85591.1 - 1.2e-36 126.1 20.5 1.2e-36 126.1 20.5 6.1 3 1 3 6 6 6 1 Domain of unknown function (DUF3381) Methyltr_RsmB-F PF01189.17 EFA85591.1 - 0.04 13.6 1.8 0.13 11.9 0.0 2.5 2 1 0 2 2 2 0 16S rRNA methyltransferase RsmB/F RF3_C PF16658.5 EFA85591.1 - 1 9.2 0.0 1 9.2 0.0 3.8 4 0 0 4 4 4 0 Class II release factor RF3, C-terminal domain CRR7 PF12095.8 EFA85591.1 - 1.7 9.2 8.4 0.84 10.1 5.1 2.3 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 TBCA PF02970.16 EFA85592.1 - 2.3e-23 82.3 10.3 2.3e-23 82.3 10.3 1.3 2 0 0 2 2 2 1 Tubulin binding cofactor A DUF4200 PF13863.6 EFA85592.1 - 0.0011 19.3 12.4 0.0014 19.0 12.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) DHR10 PF18595.1 EFA85592.1 - 0.0037 17.3 8.1 0.034 14.2 3.5 2.1 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain DASH_Dad4 PF08650.10 EFA85592.1 - 0.092 12.7 2.8 0.17 11.9 0.3 2.5 2 1 0 2 2 2 0 DASH complex subunit Dad4 Fib_alpha PF08702.10 EFA85592.1 - 0.14 12.3 11.0 0.18 12.0 11.0 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FapA PF03961.13 EFA85592.1 - 0.18 10.4 7.6 0.22 10.1 7.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A HMMR_N PF15905.5 EFA85592.1 - 0.19 11.2 11.9 0.22 11.0 11.9 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Spectrin PF00435.21 EFA85592.1 - 0.26 11.8 6.0 0.46 11.0 2.2 2.1 1 1 1 2 2 2 0 Spectrin repeat Prominin PF05478.11 EFA85592.1 - 0.27 9.1 5.8 0.31 8.9 5.8 1.1 1 0 0 1 1 1 0 Prominin CotJB PF12652.7 EFA85592.1 - 0.28 11.4 4.0 0.63 10.3 0.1 2.2 2 0 0 2 2 2 0 CotJB protein EMC3_TMCO1 PF01956.16 EFA85592.1 - 0.3 10.8 2.0 0.33 10.7 2.0 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DASH_Dam1 PF08653.10 EFA85592.1 - 0.3 10.9 1.6 0.58 10.0 0.3 2.1 2 1 0 2 2 2 0 DASH complex subunit Dam1 CENP-Q PF13094.6 EFA85592.1 - 0.38 10.9 8.9 1.3 9.2 9.0 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Exonuc_VII_L PF02601.15 EFA85592.1 - 0.58 9.7 5.3 0.67 9.5 5.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EFA85592.1 - 1.9 6.3 6.8 2.1 6.1 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EFA85592.1 - 4.1 8.1 8.6 53 4.5 8.6 2.0 1 1 0 1 1 1 0 Initiation control protein YabA TcA_RBD PF18518.1 EFA85593.1 - 0.0074 16.6 1.6 0.01 16.1 1.6 1.3 1 0 0 1 1 1 1 TcA receptor binding domain DUF2529 PF10740.9 EFA85593.1 - 0.012 15.2 0.1 0.015 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) LPP20 PF02169.16 EFA85593.1 - 0.028 14.7 6.5 0.048 14.0 6.5 1.3 1 0 0 1 1 1 0 LPP20 lipoprotein Peptidase_U57 PF05582.12 EFA85593.1 - 0.046 13.0 1.0 0.06 12.6 1.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 GST_C_3 PF14497.6 EFA85596.1 - 4e-17 62.2 0.0 6.1e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA85596.1 - 6.8e-09 36.0 0.0 2.8e-08 34.0 0.0 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA85596.1 - 0.00014 22.0 0.1 0.00032 20.8 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA85596.1 - 0.0065 16.9 0.0 0.018 15.4 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFA85596.1 - 0.035 14.1 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFA85596.1 - 0.08 12.8 0.0 0.2 11.5 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ank_2 PF12796.7 EFA85597.1 - 2.3e-28 98.6 2.2 1.8e-05 25.3 0.0 6.8 3 2 4 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85597.1 - 4.8e-26 90.8 13.9 0.0005 20.6 0.1 10.9 8 4 6 14 14 14 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85597.1 - 1.4e-23 80.3 5.8 0.024 15.1 0.0 13.2 12 1 2 14 14 14 4 Ankyrin repeat Ank_5 PF13857.6 EFA85597.1 - 1.9e-20 72.7 8.2 0.031 14.6 0.1 11.5 6 2 7 13 13 13 7 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA85597.1 - 8.8e-06 25.6 14.4 0.53 10.3 0.0 7.1 4 2 5 9 9 9 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA85597.1 - 1e-05 25.8 1.6 0.26 11.8 0.1 6.4 5 1 0 5 5 5 1 Ankyrin repeat DUF249 PF03158.13 EFA85597.1 - 0.04 13.6 15.3 0.25 11.0 3.4 4.8 3 1 1 4 4 4 0 Multigene family 530 protein FKBP_C PF00254.28 EFA85598.1 - 3.3e-14 53.0 0.1 1.8e-12 47.4 0.1 2.1 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Csm1 PF12539.8 EFA85598.1 - 0.14 12.8 0.0 0.18 12.5 0.0 1.3 1 0 0 1 1 1 0 Chromosome segregation protein Csm1/Pcs1 Calici_coat PF00915.20 EFA85599.1 - 0.15 10.9 2.3 0.16 10.8 2.3 1.0 1 0 0 1 1 1 0 Calicivirus coat protein FNIP PF05725.12 EFA85601.1 - 0.011 15.9 0.2 0.044 14.0 0.2 2.1 1 1 0 1 1 1 0 FNIP Repeat RVT_1 PF00078.27 EFA85602.1 - 1.7e-25 89.8 0.5 4.3e-25 88.5 0.5 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EFA85602.1 - 3.1e-23 82.1 0.6 1.1e-22 80.3 0.2 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA85602.1 - 1.9e-22 79.2 0.1 5.7e-22 77.6 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EFA85602.1 - 9.1e-17 60.9 0.2 9.1e-17 60.9 0.2 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EFA85602.1 - 8.9e-12 45.2 0.0 2.4e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EFA85602.1 - 0.0066 16.6 1.7 0.0094 16.2 0.3 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Retrotrans_gag PF03732.17 EFA85602.1 - 0.0075 16.5 0.2 0.035 14.4 0.2 2.2 1 0 0 1 1 1 1 Retrotransposon gag protein FNIP PF05725.12 EFA85603.1 - 1.7e-27 95.3 17.7 1.3e-08 34.9 0.1 6.8 3 2 4 7 7 7 7 FNIP Repeat F-box_5 PF18511.1 EFA85603.1 - 0.0023 17.5 0.1 0.0056 16.2 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA85603.1 - 0.012 15.5 0.3 0.032 14.1 0.3 1.7 1 0 0 1 1 1 0 F-box-like SwrA PF17423.2 EFA85603.1 - 0.031 14.2 1.0 0.11 12.4 0.9 2.1 1 1 0 1 1 1 0 Swarming motility protein Rab3-GTPase_cat PF13890.6 EFA85604.1 - 1e-44 152.1 1.1 4.4e-44 150.0 0.0 2.7 3 1 0 3 3 3 1 Rab3 GTPase-activating protein catalytic subunit SIS PF01380.22 EFA85605.1 - 5e-08 32.9 1.9 0.0018 18.1 0.0 3.3 2 1 0 2 2 2 2 SIS domain CBM49 PF09478.10 EFA85606.1 - 5.3e-11 42.7 0.2 1.2e-10 41.6 0.2 1.5 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 DRMBL PF07522.14 EFA85607.1 - 1.1e-15 57.8 0.1 1.1e-15 57.8 0.1 2.5 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 EFA85607.1 - 0.055 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EFA85608.1 - 0.0042 16.6 0.0 0.0068 15.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain BUD22 PF09073.10 EFA85608.1 - 0.061 12.7 31.1 0.084 12.2 31.1 1.1 1 0 0 1 1 1 0 BUD22 PRR22 PF15776.5 EFA85608.1 - 0.46 9.8 3.0 0.69 9.2 3.0 1.2 1 0 0 1 1 1 0 Proline-rich protein family 22 Mucin PF01456.17 EFA85608.1 - 1.3 9.0 26.0 2.4 8.1 26.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Atrophin-1 PF03154.15 EFA85608.1 - 3.3 5.9 22.5 4.3 5.5 22.5 1.0 1 0 0 1 1 1 0 Atrophin-1 family HTH_Tnp_4 PF13613.6 EFA85609.1 - 3.3e-06 26.7 0.4 8.3e-06 25.4 0.4 1.7 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_4 PF13359.6 EFA85610.1 - 0.00039 20.1 0.0 0.00086 19.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Rad50_zn_hook PF04423.14 EFA85610.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.0 2 0 0 2 2 2 0 Rad50 zinc hook motif PRKCSH_1 PF13015.6 EFA85611.1 - 1.1e-11 44.7 1.1 0.00013 21.7 0.0 2.7 3 0 0 3 3 3 2 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA85611.1 - 5.2e-07 29.8 4.9 0.00031 20.8 0.3 2.9 3 0 0 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EFA85611.1 - 2e-06 27.8 1.4 0.0035 17.3 0.6 2.2 1 1 1 2 2 2 2 Autophagy-related protein 27 RVT_1 PF00078.27 EFA85613.1 - 2.2e-26 92.8 0.5 7.9e-26 90.9 0.1 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EFA85613.1 - 1.2e-21 77.0 0.0 4.1e-21 75.3 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA85613.1 - 2.8e-18 65.8 0.0 7.8e-18 64.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EFA85613.1 - 8.6e-12 45.3 0.0 1.9e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EFA85613.1 - 4.1e-11 42.8 1.7 7e-11 42.1 0.1 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 EFA85613.1 - 4.4e-07 30.4 0.2 1.3e-06 28.9 0.2 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EFA85613.1 - 2e-06 28.4 0.0 5e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 EFA85613.1 - 1.6e-05 24.8 0.5 3.4e-05 23.7 0.5 1.6 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.20 EFA85613.1 - 0.0012 19.2 0.2 0.0029 17.9 0.2 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Corona_nucleoca PF00937.18 EFA85615.1 - 0.0036 16.4 2.6 0.0054 15.8 2.6 1.2 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein SR-25 PF10500.9 EFA85615.1 - 0.013 15.1 5.9 0.025 14.2 5.9 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EFA85615.1 - 0.13 12.9 4.5 0.33 11.6 4.5 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein PNPase PF03726.14 EFA85615.1 - 0.46 11.0 6.0 14 6.2 0.1 3.6 1 1 2 4 4 4 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF3439 PF11921.8 EFA85616.1 - 2.2 8.3 7.8 20 5.2 6.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Tir_receptor_C PF07489.11 EFA85616.1 - 7.6 6.4 15.4 12 5.8 15.4 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Arf PF00025.21 EFA85618.1 - 2.8e-58 196.2 0.0 3.8e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA85618.1 - 4e-14 52.9 0.6 8.5e-14 51.8 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA85618.1 - 3e-13 49.6 0.6 4.4e-13 49.1 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA85618.1 - 9.3e-12 44.8 0.0 1.1e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFA85618.1 - 3.6e-09 36.3 0.3 5.9e-09 35.6 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFA85618.1 - 9.4e-08 31.6 8.7 0.00043 19.5 4.4 3.0 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFA85618.1 - 1.6e-07 31.4 0.0 4e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase MobB PF03205.14 EFA85618.1 - 0.0018 18.2 0.1 0.0035 17.3 0.1 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 EFA85618.1 - 0.0041 17.4 0.5 0.044 14.1 0.1 2.4 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 EFA85618.1 - 0.0094 15.5 0.2 0.54 9.8 0.2 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EFA85618.1 - 0.025 14.2 0.2 0.3 10.7 0.2 2.2 1 1 0 2 2 2 0 SRP54-type protein, GTPase domain DLIC PF05783.11 EFA85618.1 - 0.032 13.1 0.1 0.043 12.7 0.1 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_33 PF13671.6 EFA85618.1 - 0.036 14.2 0.0 0.064 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA85618.1 - 0.046 14.2 1.1 0.12 12.9 1.1 2.0 1 1 0 1 1 1 0 ABC transporter AAA PF00004.29 EFA85618.1 - 0.046 14.1 0.3 0.23 11.9 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFA85618.1 - 0.057 13.3 0.2 4.5 7.2 0.1 2.3 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.6 EFA85618.1 - 0.091 12.5 0.1 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain MFS_1 PF07690.16 EFA85619.1 - 4.7e-42 144.2 7.3 5.8e-42 143.9 7.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA85619.1 - 5e-13 48.7 0.0 6.6e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EFA85619.1 - 1.3e-11 44.0 0.0 2.2e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 EFA85619.1 - 3e-06 26.8 4.4 4.4e-06 26.2 4.4 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB LacY_symp PF01306.19 EFA85619.1 - 5.4e-06 25.4 7.1 8.3e-05 21.5 7.1 2.0 1 1 0 1 1 1 1 LacY proton/sugar symporter MFS_2 PF13347.6 EFA85619.1 - 5.9e-05 21.8 5.8 8.6e-05 21.3 5.8 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein BT1 PF03092.16 EFA85619.1 - 0.0001 20.7 0.1 0.00028 19.2 0.1 1.7 1 1 0 1 1 1 1 BT1 family MFS_3 PF05977.13 EFA85619.1 - 0.001 17.5 6.2 0.047 12.1 3.1 2.1 1 1 1 2 2 2 2 Transmembrane secretion effector Plasmod_dom_1 PF09715.10 EFA85619.1 - 0.0066 16.5 0.1 0.051 13.6 0.0 2.6 3 0 0 3 3 2 1 Plasmodium protein of unknown function (Plasmod_dom_1) Gly-zipper_Omp PF13488.6 EFA85619.1 - 0.0096 15.9 4.6 0.019 15.0 4.6 1.4 1 0 0 1 1 1 1 Glycine zipper PTR2 PF00854.21 EFA85619.1 - 0.031 13.1 11.0 0.011 14.7 2.8 2.3 2 0 0 2 2 2 0 POT family OATP PF03137.20 EFA85619.1 - 0.085 11.1 18.6 0.078 11.3 2.6 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF4718 PF15842.5 EFA85619.1 - 3 7.6 4.6 0.52 10.1 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) RRM_1 PF00076.22 EFA85620.1 - 5.9e-21 74.1 0.0 7e-10 38.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cnl2_NKP2 PF09447.10 EFA85620.1 - 0.086 13.0 0.4 0.63 10.2 0.0 2.2 2 0 0 2 2 2 0 Cnl2/NKP2 family protein PseudoU_synth_2 PF00849.22 EFA85621.1 - 6e-24 84.9 13.7 4.3e-22 78.9 11.0 3.7 2 1 0 2 2 2 1 RNA pseudouridylate synthase S4_2 PF13275.6 EFA85621.1 - 0.0022 17.8 0.0 0.007 16.2 0.0 1.8 1 0 0 1 1 1 1 S4 domain S4 PF01479.25 EFA85621.1 - 0.0053 16.4 0.5 0.016 14.9 0.1 2.0 2 0 0 2 2 2 1 S4 domain DUF676 PF05057.14 EFA85622.1 - 1.8e-32 112.6 0.9 2.6e-32 112.1 0.1 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFA85622.1 - 5.2e-05 23.1 0.0 0.00012 21.9 0.0 1.7 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EFA85622.1 - 0.00076 19.4 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) LCAT PF02450.15 EFA85622.1 - 0.0019 17.5 0.0 0.0037 16.5 0.0 1.5 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Palm_thioest PF02089.15 EFA85622.1 - 0.0083 16.0 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_2 PF01674.18 EFA85622.1 - 0.019 14.5 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 2) Abhydrolase_1 PF00561.20 EFA85622.1 - 0.049 13.3 0.3 0.15 11.7 0.0 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EFA85622.1 - 0.096 12.5 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold YajC PF02699.15 EFA85622.1 - 0.17 11.8 1.5 0.33 10.9 1.5 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit COesterase PF00135.28 EFA85623.1 - 4.3e-102 342.6 0.1 5.2e-102 342.3 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFA85623.1 - 3.5e-09 36.8 0.2 9e-09 35.5 0.2 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EFA85623.1 - 0.0011 18.6 0.8 0.0054 16.4 0.8 1.9 1 1 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 EFA85623.1 - 0.0073 16.9 0.5 0.0073 16.9 0.5 2.2 1 1 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFA85623.1 - 0.023 14.2 0.1 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family HEPN PF05168.14 EFA85624.1 - 2.2e-13 50.4 0.9 7.3e-13 48.7 0.9 2.0 1 0 0 1 1 1 1 HEPN domain HATPase_c_3 PF13589.6 EFA85624.1 - 0.033 14.0 0.8 0.94 9.3 0.1 3.2 2 2 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3216 PF11505.8 EFA85624.1 - 0.21 11.8 0.7 2.6 8.3 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3216) HEPN PF05168.14 EFA85625.1 - 4.6e-14 52.5 0.4 2e-13 50.5 0.4 2.2 1 0 0 1 1 1 1 HEPN domain HATPase_c_3 PF13589.6 EFA85625.1 - 0.00062 19.6 0.2 2.3 8.0 0.0 3.2 2 1 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Frizzled PF01534.17 EFA85626.1 - 0.00026 20.1 9.7 0.0021 17.2 9.7 1.9 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region FKBP_C PF00254.28 EFA85629.1 - 2.9e-26 91.6 0.0 1.1e-25 89.8 0.0 2.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF812 PF05667.11 EFA85629.1 - 2.2e-05 23.6 9.9 2.2e-05 23.6 9.9 5.3 1 1 4 5 5 5 2 Protein of unknown function (DUF812) WH1 PF00568.23 EFA85629.1 - 0.00089 19.2 0.1 0.0018 18.2 0.1 1.5 1 0 0 1 1 1 1 WH1 domain Acetyltransf_11 PF13720.6 EFA85629.1 - 7.6 7.1 10.9 8.8 6.9 0.8 4.3 2 1 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SPATA1_C PF15743.5 EFA85630.1 - 0.098 12.7 0.9 0.12 12.5 0.9 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus cNMP_binding PF00027.29 EFA85631.1 - 3.5e-27 94.3 0.0 3.7e-16 59.0 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain ARID PF01388.21 EFA85631.1 - 5.2e-20 71.9 0.5 2.1e-19 70.0 0.0 2.4 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Lactamase_B PF00753.27 EFA85631.1 - 4.9e-06 26.7 0.0 1.3e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFA85631.1 - 0.0017 17.9 0.0 0.0035 16.9 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Cupin_2 PF07883.11 EFA85631.1 - 0.7 9.6 0.0 0.7 9.6 0.0 2.1 2 0 0 2 2 2 0 Cupin domain Pkinase PF00069.25 EFA85632.1 - 4.8e-42 144.1 0.0 4.9e-40 137.5 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85632.1 - 2.4e-39 135.2 0.0 4e-34 118.1 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA85632.1 - 0.00044 19.2 0.0 0.00069 18.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFA85632.1 - 0.0037 17.2 0.0 0.063 13.2 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFA85632.1 - 0.02 14.3 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFA85632.1 - 0.041 12.8 0.3 0.13 11.2 0.3 1.7 1 1 0 1 1 1 0 Haspin like kinase domain ACDC PF14733.6 EFA85633.1 - 0.0065 16.8 0.4 0.0091 16.3 0.4 1.2 1 0 0 1 1 1 1 AP2-coincident C-terminal Methyltransf_31 PF13847.6 EFA85633.1 - 0.084 12.7 0.1 0.097 12.5 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M76 PF09768.9 EFA85633.1 - 0.09 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase M76 family DUF1858 PF08984.11 EFA85634.1 - 0.24 11.6 0.4 17 5.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1858) zf-B_box PF00643.24 EFA85635.1 - 2.7e-08 33.8 6.6 5.4e-08 32.9 6.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA85635.1 - 0.00025 21.2 0.1 0.00068 19.8 0.1 1.8 1 0 0 1 1 1 1 Kelch motif MtrG PF04210.13 EFA85635.1 - 1.2 9.0 2.8 1.6 8.6 0.8 2.2 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G IZUMO PF15005.6 EFA85636.1 - 1.3 9.5 5.5 13 6.3 0.1 3.6 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated SMYLE_N PF18615.1 EFA85637.1 - 0.002 17.8 5.4 0.0035 17.0 5.4 1.3 1 0 0 1 1 1 1 Short myomegalin-like EB1 binding proteins, N-terminal domain Opi1 PF08618.10 EFA85637.1 - 0.079 12.2 4.9 0.14 11.4 4.9 1.3 1 0 0 1 1 1 0 Transcription factor Opi1 zf-CCHC_3 PF13917.6 EFA85638.1 - 1.1e-17 63.6 1.1 2e-17 62.9 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle BUD22 PF09073.10 EFA85638.1 - 0.57 9.5 35.7 0.7 9.2 35.7 1.1 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 EFA85638.1 - 1.8 7.0 22.1 1.9 7.0 22.1 1.0 1 0 0 1 1 1 0 Macoilin family PPP4R2 PF09184.11 EFA85638.1 - 2.5 7.6 23.8 2.9 7.4 23.8 1.1 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 EFA85638.1 - 5.4 5.1 28.4 6.7 4.8 28.4 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 EFA85638.1 - 6 5.5 15.9 7.3 5.2 15.9 1.1 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 EFA85638.1 - 6.6 7.0 17.6 9.3 6.5 17.6 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF179 PF02622.15 EFA85639.1 - 3.3e-12 46.7 0.1 5.5e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Complex1_LYR PF05347.15 EFA85639.1 - 0.012 15.6 0.2 0.027 14.5 0.2 1.7 1 0 0 1 1 1 0 Complex 1 protein (LYR family) RasGEF_N PF00618.20 EFA85639.1 - 7.9 6.8 8.8 16 5.8 7.3 2.3 2 1 0 2 2 2 0 RasGEF N-terminal motif Glyco_tranf_2_4 PF13704.6 EFA85640.1 - 0.11 13.1 0.3 21 5.7 0.2 2.5 2 1 0 2 2 2 0 Glycosyl transferase family 2 eRF1_2 PF03464.15 EFA85641.1 - 3e-45 153.8 0.0 6.5e-45 152.7 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFA85641.1 - 2.5e-35 121.4 0.1 2.5e-35 121.4 0.1 2.0 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 EFA85641.1 - 7.3e-20 71.3 1.8 2.5e-19 69.5 0.0 2.3 2 0 0 2 2 2 1 eRF1 domain 1 baeRF_family10 PF18854.1 EFA85641.1 - 6.2e-09 36.2 0.0 1.1e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EFA85641.1 - 3.5e-07 30.6 0.0 5.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor GST_C_3 PF14497.6 EFA85642.1 - 9.8e-20 70.6 0.0 1.5e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFA85642.1 - 7.6e-11 42.2 0.0 1.7e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA85642.1 - 8.9e-06 25.8 0.1 1.2e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA85642.1 - 1.2e-05 25.2 0.4 2.5e-05 24.2 0.4 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA85642.1 - 1.4e-05 25.4 0.0 4e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain LA-virus_coat PF09220.10 EFA85642.1 - 0.09 11.4 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 L-A virus, major coat protein GST_N PF02798.20 EFA85643.1 - 1.1e-12 48.1 0.2 2.5e-12 47.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFA85643.1 - 3.3e-12 46.5 0.2 6.6e-12 45.5 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFA85643.1 - 6.1e-05 23.4 0.4 0.00041 20.7 0.1 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFA85643.1 - 0.00061 20.0 0.1 0.0011 19.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFA85643.1 - 0.00071 19.6 0.0 0.0031 17.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain YqgF PF14639.6 EFA85643.1 - 0.0022 17.8 0.2 0.017 14.9 0.0 2.0 1 1 1 2 2 2 1 Holliday-junction resolvase-like of SPT6 Ras PF00071.22 EFA85644.1 - 4.9e-11 42.5 0.3 3.1e-09 36.6 0.2 2.2 2 0 0 2 2 2 1 Ras family Arf PF00025.21 EFA85644.1 - 0.00011 21.7 0.3 0.41 10.1 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA85644.1 - 0.0018 17.8 0.3 0.0073 15.9 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EFA85644.1 - 0.0061 16.8 0.9 0.11 12.7 0.1 2.9 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFA85644.1 - 0.017 14.9 0.1 0.23 11.2 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 EFA85644.1 - 0.091 12.1 0.1 0.37 10.1 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family TPR_1 PF00515.28 EFA85645.1 - 4.4e-28 95.9 29.7 1.1e-07 31.3 0.1 8.5 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85645.1 - 4.7e-28 95.0 20.2 4.5e-06 26.4 0.1 9.0 9 0 0 9 9 9 5 Tetratricopeptide repeat DnaJ PF00226.31 EFA85645.1 - 3e-25 88.1 3.5 3e-25 88.1 3.5 2.1 2 0 0 2 2 1 1 DnaJ domain TPR_19 PF14559.6 EFA85645.1 - 3e-19 69.3 26.8 4.1e-05 24.0 2.7 7.2 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFA85645.1 - 5.7e-16 57.3 20.3 0.0018 18.3 0.2 8.3 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFA85645.1 - 3.6e-15 55.3 28.8 4.1e-06 26.4 0.5 8.0 4 3 4 8 8 8 5 TPR repeat TPR_16 PF13432.6 EFA85645.1 - 3.9e-14 53.0 10.0 1.9e-05 25.2 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFA85645.1 - 1.2e-08 35.1 6.5 1.7 9.7 0.0 7.3 4 2 4 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFA85645.1 - 4.7e-08 32.9 15.9 0.033 14.6 0.0 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFA85645.1 - 1.1e-07 31.3 1.2 0.29 11.3 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA85645.1 - 1.3e-07 31.8 14.0 0.14 12.4 0.1 5.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFA85645.1 - 5.3e-06 26.5 6.1 0.021 15.0 0.1 3.6 4 1 0 4 4 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA85645.1 - 2.7e-05 24.3 17.7 0.03 14.6 0.9 5.3 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 GATase1_like PF07090.11 EFA85645.1 - 0.029 13.8 0.2 0.7 9.3 0.1 2.4 2 0 0 2 2 2 0 Putative glutamine amidotransferase BTAD PF03704.17 EFA85645.1 - 0.17 12.3 0.7 4.4 7.7 0.5 3.1 2 2 0 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 EFA85645.1 - 0.85 9.6 9.1 22 5.1 0.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank_2 PF12796.7 EFA85646.1 - 3.3e-09 37.2 2.0 1.5e-05 25.5 0.1 3.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA85646.1 - 3.5e-08 33.1 6.6 0.33 11.6 0.0 6.3 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFA85646.1 - 1.3e-05 25.6 6.5 0.76 10.4 0.2 5.3 4 2 0 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA85647.1 - 0.00015 22.3 0.0 0.016 15.8 0.0 3.1 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA85647.1 - 0.00037 20.7 0.2 4.6 8.1 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 EFA85647.1 - 0.0029 18.1 0.2 10 6.9 0.0 4.4 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85647.1 - 0.0052 17.1 0.0 2.1 8.8 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeats (many copies) AnkUBD PF18418.1 EFA85647.1 - 0.09 12.9 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain Ank_3 PF13606.6 EFA85648.1 - 0.004 17.5 0.9 9.6 7.2 0.0 4.3 6 0 0 6 6 6 2 Ankyrin repeat Ank_2 PF12796.7 EFA85648.1 - 0.053 14.1 0.0 12 6.6 0.0 3.0 2 1 2 4 4 4 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85648.1 - 0.058 14.0 0.2 42 4.9 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA85649.1 - 3.1e-05 24.4 0.5 0.052 14.1 0.0 4.5 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFA85649.1 - 0.00071 20.1 0.0 0.0064 17.1 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA85649.1 - 0.0037 17.7 0.2 12 6.9 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeat YscO PF07321.12 EFA85649.1 - 0.49 10.3 2.9 1.9 8.4 0.2 2.2 2 0 0 2 2 2 0 Type III secretion protein YscO Sec1 PF00995.23 EFA85652.1 - 2.5e-45 155.8 0.2 2.9e-45 155.6 0.2 1.1 1 0 0 1 1 1 1 Sec1 family FAD_binding_4 PF01565.23 EFA85653.1 - 4.2e-29 101.1 0.2 6.5e-29 100.4 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFA85653.1 - 1e-15 57.6 5.5 2.9e-15 56.1 5.5 1.9 1 0 0 1 1 1 1 Berberine and berberine like Choline_transpo PF04515.12 EFA85656.1 - 7.8e-81 271.8 31.5 7.8e-81 271.8 31.5 2.2 2 1 1 3 3 3 2 Plasma-membrane choline transporter Cnd3 PF12719.7 EFA85657.1 - 1.3e-09 37.7 6.0 1.3e-09 37.7 6.0 2.9 2 1 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EFA85657.1 - 1.4e-07 31.8 0.2 0.00044 20.6 0.2 3.0 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 EFA85657.1 - 0.00038 20.5 0.5 14 6.2 0.0 5.5 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EFA85657.1 - 0.0009 19.3 9.4 0.058 13.4 0.1 3.7 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HSP70 PF00012.20 EFA85658.1 - 0.0057 14.9 1.1 0.0072 14.6 1.1 1.0 1 0 0 1 1 1 1 Hsp70 protein HARE-HTH PF05066.13 EFA85658.1 - 0.031 14.7 0.6 0.15 12.5 0.0 2.0 1 1 1 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain DUF4271 PF14093.6 EFA85659.1 - 0.083 12.8 3.7 0.13 12.2 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) EphA2_TM PF14575.6 EFA85659.1 - 5.2 8.0 6.8 18 6.3 0.0 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Spt20 PF12090.8 EFA85659.1 - 6.1 6.4 24.5 11 5.6 24.5 1.4 1 0 0 1 1 1 0 Spt20 family SMC_N PF02463.19 EFA85660.1 - 1.8e-46 158.4 20.6 5.7e-46 156.7 20.6 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFA85660.1 - 4.6e-23 81.8 0.0 2.4e-22 79.5 0.0 2.4 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFA85660.1 - 6.8e-14 52.4 13.2 1.4e-07 31.6 0.4 3.8 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFA85660.1 - 8.1e-11 42.8 32.5 8.1e-11 42.8 32.5 7.2 3 2 1 4 4 4 1 AAA domain AAA_15 PF13175.6 EFA85660.1 - 5.6e-07 29.6 12.8 5.6e-07 29.6 12.8 5.2 3 2 2 5 5 5 2 AAA ATPase domain DUF3584 PF12128.8 EFA85660.1 - 0.00054 17.7 23.9 0.00054 17.7 23.9 5.2 3 2 2 5 5 5 1 Protein of unknown function (DUF3584) TPR_5 PF12688.7 EFA85660.1 - 0.018 15.3 0.1 0.11 12.8 0.1 2.4 1 0 0 1 1 1 0 Tetratrico peptide repeat AAA_29 PF13555.6 EFA85660.1 - 0.019 14.7 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFA85660.1 - 0.35 11.4 0.1 0.35 11.4 0.1 6.3 4 1 0 4 4 4 0 ABC transporter Cnd1 PF12717.7 EFA85661.1 - 1.2e-05 25.5 14.6 0.0056 16.7 0.9 5.2 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFA85661.1 - 0.021 15.2 0.0 0.33 11.4 0.0 3.0 3 0 0 3 3 3 0 HEAT repeats FANCI_S2 PF14676.6 EFA85661.1 - 0.058 13.7 3.3 1.3 9.3 0.9 3.4 2 1 1 3 3 3 0 FANCI solenoid 2 Rrn6 PF10214.9 EFA85662.1 - 0.072 11.6 9.9 0.072 11.6 9.9 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC27 PF09507.10 EFA85662.1 - 0.43 9.9 33.4 0.53 9.6 33.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF2981 PF11200.8 EFA85662.1 - 2.4 7.8 11.6 2.6 7.7 11.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) FAM60A PF15396.6 EFA85662.1 - 3.8 7.5 16.1 6.1 6.8 16.1 1.5 1 0 0 1 1 1 0 Protein Family FAM60A 2OG-FeII_Oxy_3 PF13640.6 EFA85663.1 - 4.9e-06 27.4 0.0 1.2e-05 26.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EFA85665.1 - 1.3e-06 29.2 0.0 2.7e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EFA85666.1 - 8.3e-07 29.8 0.0 1.9e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CENP-B_dimeris PF09026.10 EFA85666.1 - 6.7 7.2 10.4 13 6.2 8.1 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ank_2 PF12796.7 EFA85668.1 - 0.0021 18.6 0.0 0.023 15.2 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA85668.1 - 0.0043 17.4 0.1 12 6.8 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat DUF4116 PF13475.6 EFA85668.1 - 0.023 14.4 2.5 2.6 7.8 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4116) Ank_4 PF13637.6 EFA85668.1 - 0.061 13.9 0.1 9.1 7.0 0.0 4.0 4 1 1 5 5 5 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85668.1 - 0.09 13.1 0.0 16 6.0 0.0 4.1 5 1 0 5 5 5 0 Ankyrin repeats (many copies) Lamprin PF06403.11 EFA85669.1 - 0.15 12.0 3.8 0.24 11.4 3.8 1.2 1 0 0 1 1 1 0 Lamprin 2OG-FeII_Oxy_3 PF13640.6 EFA85670.1 - 1.1e-07 32.6 0.0 2.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF5113 PF17140.4 EFA85671.1 - 0.0094 15.8 0.2 0.027 14.3 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5113) RIH_assoc PF08454.11 EFA85671.1 - 8.7 6.3 7.8 1.4 8.8 0.1 3.3 3 1 0 3 3 3 0 RyR and IP3R Homology associated GPCR_chapero_1 PF11904.8 EFA85672.1 - 1.1e-52 179.4 4.5 1.5e-52 179.0 4.5 1.2 1 0 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.7 EFA85672.1 - 3.4e-06 27.6 0.0 6.6e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85672.1 - 7.1e-06 26.5 0.0 1.7e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFA85672.1 - 0.0018 18.6 0.2 0.0069 16.8 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EFA85672.1 - 0.0037 17.7 0.1 0.2 12.3 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFA85672.1 - 0.0062 16.8 0.1 0.018 15.4 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Spore-coat_CotD PF11122.8 EFA85672.1 - 0.05 14.4 2.6 0.16 12.8 2.6 1.8 1 0 0 1 1 1 0 Inner spore coat protein D DUF3439 PF11921.8 EFA85672.1 - 0.2 11.6 6.3 0.48 10.4 6.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EFA85672.1 - 0.51 10.3 11.4 0.92 9.5 11.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein 7tm_3 PF00003.22 EFA85673.1 - 2e-32 112.8 10.7 3e-32 112.3 10.7 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Bmp PF02608.14 EFA85673.1 - 1.4e-15 57.0 9.6 1.9e-15 56.6 9.6 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like DUF3213 PF11491.8 EFA85675.1 - 1.1 9.5 6.2 0.63 10.3 2.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3213) PAP_central PF04928.17 EFA85675.1 - 2.1 7.3 6.6 0.26 10.2 2.4 1.6 2 0 0 2 2 2 0 Poly(A) polymerase central domain WD40 PF00400.32 EFA85677.1 - 6.1e-31 106.0 9.6 1.9e-06 28.5 0.1 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85677.1 - 2.8e-11 43.5 0.1 0.013 15.8 0.0 4.7 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Metallophos PF00149.28 EFA85678.1 - 2.1e-13 51.3 1.4 4.8e-13 50.1 1.4 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA85678.1 - 2.4e-07 31.1 0.0 0.0028 17.8 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain CLU PF13236.6 EFA85678.1 - 0.072 12.9 0.0 0.69 9.7 0.0 2.0 2 0 0 2 2 2 0 Clustered mitochondria ECH_1 PF00378.20 EFA85679.1 - 2.6e-55 187.5 0.0 3.1e-55 187.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFA85679.1 - 9e-31 107.6 0.0 1.5e-28 100.3 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase CAP PF00188.26 EFA85680.1 - 1.2e-08 35.8 5.3 1.2e-08 35.8 5.3 2.1 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Utp14 PF04615.13 EFA85680.1 - 3.2 6.2 5.3 4 5.9 5.3 1.0 1 0 0 1 1 1 0 Utp14 protein SOG2 PF10428.9 EFA85680.1 - 5.4 6.1 26.9 8.2 5.5 26.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein WD40 PF00400.32 EFA85681.1 - 4e-07 30.6 0.0 6.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat Peptidase_M66 PF10462.9 EFA85682.1 - 1.3e-90 303.5 4.2 1.8e-90 303.0 4.2 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.6 EFA85682.1 - 0.02 15.4 0.1 0.048 14.2 0.1 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 EFA85682.1 - 0.032 12.8 0.0 0.056 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M10 PF00413.24 EFA85682.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 EFA85683.1 - 1.6e-91 306.4 3.2 1.6e-91 306.4 3.2 1.5 2 0 0 2 2 2 1 Peptidase M66 Reprolysin_3 PF13582.6 EFA85683.1 - 0.01 16.4 0.4 0.033 14.7 0.1 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 EFA85683.1 - 0.032 12.8 0.0 0.052 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 EFA85683.1 - 0.043 14.0 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4614 PF15391.6 EFA85683.1 - 0.065 13.2 2.5 0.11 12.5 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) GRP PF07172.11 EFA85683.1 - 0.98 10.2 4.7 6.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Glycine rich protein family Gpi16 PF04113.14 EFA85684.1 - 9.3e-66 222.4 5.1 1.9e-57 195.0 1.2 2.0 1 1 1 2 2 2 2 Gpi16 subunit, GPI transamidase component SAM_decarbox PF01536.16 EFA85685.1 - 9.4e-104 347.2 0.0 1.1e-103 347.0 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase MutS_V PF00488.21 EFA85686.1 - 1e-83 280.0 0.2 1.8e-83 279.2 0.2 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFA85686.1 - 3.7e-25 89.3 0.9 3.7e-25 89.3 0.9 2.3 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EFA85686.1 - 1.2e-11 45.0 0.3 3.4e-11 43.6 0.0 1.9 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.20 EFA85686.1 - 3.7e-05 23.9 0.0 0.0055 16.9 0.1 2.7 2 0 0 2 2 2 1 MutS domain I AAA_27 PF13514.6 EFA85686.1 - 0.0025 17.4 0.0 0.006 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain MutS_IV PF05190.18 EFA85686.1 - 0.012 15.9 3.3 0.021 15.2 0.1 2.9 4 0 0 4 4 4 0 MutS family domain IV Peptidase_M3_N PF08439.10 EFA85686.1 - 0.089 13.1 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Oligopeptidase F FAD_binding_3 PF01494.19 EFA85687.1 - 1.4e-46 159.4 0.0 1.8e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFA85687.1 - 0.0012 18.1 0.0 0.0023 17.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Anoctamin PF04547.12 EFA85687.1 - 0.0044 15.9 0.3 0.65 8.8 0.0 2.2 2 0 0 2 2 2 2 Calcium-activated chloride channel TrkA_N PF02254.18 EFA85687.1 - 0.014 15.6 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Cation_ATPase_C PF00689.21 EFA85687.1 - 0.015 15.0 2.0 0.029 14.1 2.0 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Pyr_redox_2 PF07992.14 EFA85687.1 - 0.084 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase EI24 PF07264.11 EFA85687.1 - 0.14 12.4 3.0 0.29 11.4 3.0 1.4 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Lycopene_cycl PF05834.12 EFA85687.1 - 0.18 10.8 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein UL45 PF05473.12 EFA85687.1 - 0.19 11.3 1.1 0.35 10.5 1.1 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DNase_II PF03265.15 EFA85688.1 - 5.6e-26 91.6 11.2 2.6e-25 89.4 11.2 2.2 1 1 0 1 1 1 1 Deoxyribonuclease II TIG PF01833.24 EFA85688.1 - 1.2e-23 83.0 80.0 5.9e-10 39.1 5.4 12.0 13 0 0 13 13 13 5 IPT/TIG domain SdrD_B PF17210.3 EFA85688.1 - 1e-08 35.4 10.4 9.1e-08 32.3 3.2 4.4 3 0 0 3 3 3 1 SdrD B-like domain CarboxypepD_reg PF13620.6 EFA85688.1 - 0.004 17.4 2.4 0.032 14.5 2.4 2.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain MetallophosN PF16371.5 EFA85688.1 - 0.023 14.9 0.2 0.14 12.4 0.2 2.4 1 0 0 1 1 1 0 N terminal of Calcineurin-like phosphoesterase CarbopepD_reg_2 PF13715.6 EFA85688.1 - 0.73 9.9 6.0 0.3 11.1 1.4 2.9 3 0 0 3 3 3 0 CarboxypepD_reg-like domain CTP_transf_like PF01467.26 EFA85689.1 - 2.5e-30 105.5 0.1 6.3e-30 104.3 0.1 1.7 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF5639 PF18690.1 EFA85689.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5639) Macoilin PF09726.9 EFA85689.1 - 0.2 10.2 16.6 0.28 9.7 16.6 1.2 1 0 0 1 1 1 0 Macoilin family Suf PF05843.14 EFA85689.1 - 0.86 9.5 8.2 2 8.3 8.2 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 EFA85689.1 - 2.3 5.2 12.2 3 4.9 12.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Mucin PF01456.17 EFA85689.1 - 8.5 6.4 12.2 15 5.6 12.2 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Ank_2 PF12796.7 EFA85690.1 - 2.9e-59 197.6 4.2 1.2e-12 48.3 0.0 5.6 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) RabGAP-TBC PF00566.18 EFA85690.1 - 1.2e-37 129.7 1.0 2.3e-37 128.7 1.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank PF00023.30 EFA85690.1 - 6.2e-34 115.0 3.3 0.00068 20.0 0.1 9.1 7 1 1 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 EFA85690.1 - 2.1e-31 104.4 0.6 0.0087 16.5 0.0 9.7 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.6 EFA85690.1 - 5.5e-31 106.5 2.5 3.9e-07 30.5 0.0 7.5 3 2 5 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85690.1 - 1.8e-22 79.1 0.1 0.0001 22.5 0.1 6.4 3 2 3 6 6 6 6 Ankyrin repeats (many copies) GATase_7 PF13537.6 EFA85690.1 - 0.041 13.8 0.0 36 4.3 0.0 4.4 3 2 1 5 5 5 0 Glutamine amidotransferase domain LANC_like PF05147.13 EFA85690.1 - 0.092 11.3 0.3 0.28 9.7 0.0 1.9 2 0 0 2 2 2 0 Lanthionine synthetase C-like protein eIF3_subunit PF08597.10 EFA85692.1 - 0.61 10.0 43.3 0.39 10.6 36.4 2.7 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Peptidase_C1 PF00112.23 EFA85693.1 - 1.2e-78 264.1 8.7 2.1e-78 263.4 8.7 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA85693.1 - 7e-11 42.4 6.2 1.6e-10 41.2 6.2 1.7 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFA85693.1 - 0.014 14.2 9.8 0.016 14.0 1.1 2.8 2 1 1 3 3 3 0 Peptidase C1-like family FYVE PF01363.21 EFA85694.1 - 3.8e-19 68.6 10.1 3.8e-19 68.6 10.1 1.7 2 0 0 2 2 2 1 FYVE zinc finger Arm PF00514.23 EFA85694.1 - 4.9e-06 26.4 0.2 0.044 13.8 0.0 4.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat FYVE_2 PF02318.16 EFA85694.1 - 0.011 15.9 6.7 0.011 15.9 6.7 1.6 2 0 0 2 2 2 0 FYVE-type zinc finger zf-B_box PF00643.24 EFA85694.1 - 2.1 8.6 12.9 29 4.9 9.2 2.8 2 0 0 2 2 2 0 B-box zinc finger DZR PF12773.7 EFA85694.1 - 2.2 8.4 10.2 9.9 6.3 2.3 2.5 1 1 1 2 2 2 0 Double zinc ribbon Aph-1 PF06105.12 EFA85695.1 - 6.4e-30 104.3 14.0 1.4e-22 80.2 5.4 2.0 1 1 1 2 2 2 2 Aph-1 protein Cyt-b5 PF00173.28 EFA85696.1 - 6.5e-19 67.9 0.2 9.2e-19 67.4 0.2 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Mito_carr PF00153.27 EFA85697.1 - 9.6e-46 153.7 2.0 3.7e-22 78.1 0.1 2.7 2 0 0 2 2 2 2 Mitochondrial carrier protein GMC_oxred_N PF00732.19 EFA85697.1 - 6.2e-44 150.5 4.7 2.6e-43 148.5 1.4 2.1 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFA85697.1 - 1.4e-12 48.4 0.5 3.6e-12 47.0 0.0 1.9 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFA85697.1 - 1.2e-06 27.9 6.4 2.7e-05 23.5 6.4 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFA85697.1 - 3.3e-05 24.0 0.1 0.00013 22.1 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA85697.1 - 0.00021 21.0 4.7 0.0016 18.1 4.7 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFA85697.1 - 0.0024 17.2 1.4 0.0037 16.5 1.4 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFA85697.1 - 0.0024 17.1 0.1 0.0066 15.7 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFA85697.1 - 0.019 13.7 2.3 0.031 13.0 2.3 1.3 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 EFA85697.1 - 0.021 13.9 0.1 0.034 13.2 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EFA85697.1 - 0.042 13.1 0.3 0.042 13.1 0.3 1.7 2 0 0 2 2 2 0 Thi4 family ApbA PF02558.16 EFA85697.1 - 0.081 12.6 1.4 0.16 11.6 1.4 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 EFA85697.1 - 0.31 10.3 4.6 0.51 9.6 4.6 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF4269 PF14091.6 EFA85698.1 - 0.049 13.9 0.1 0.072 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) Myb_DNA-binding PF00249.31 EFA85699.1 - 5.2e-34 116.2 12.1 1e-14 54.5 0.4 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFA85699.1 - 1.1e-27 96.0 8.1 2e-15 56.7 0.3 3.8 2 1 1 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 EFA85699.1 - 5e-05 23.3 0.1 0.54 10.3 0.0 3.3 2 1 1 3 3 3 2 SLIDE Myb_DNA-bind_4 PF13837.6 EFA85699.1 - 0.0006 20.1 10.4 0.21 12.0 0.0 4.0 3 1 0 3 3 3 2 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFA85699.1 - 0.0075 16.4 6.4 0.27 11.5 0.2 3.4 1 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EFA85699.1 - 0.015 15.1 3.0 2 8.3 0.0 3.1 3 0 0 3 3 3 0 Myb DNA-binding like Chal_sti_synt_N PF00195.19 EFA85699.1 - 0.17 11.2 1.2 0.94 8.9 0.1 2.1 1 1 1 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain MADF_DNA_bdg PF10545.9 EFA85699.1 - 1.9 8.9 5.5 2.7 8.4 0.1 2.8 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like COPI_assoc PF08507.10 EFA85702.1 - 9.2e-21 74.3 18.9 1e-20 74.1 18.9 1.0 1 0 0 1 1 1 1 COPI associated protein DUF2371 PF10177.9 EFA85702.1 - 0.015 15.5 0.6 0.015 15.5 0.6 2.7 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) EVI2A PF05399.11 EFA85702.1 - 0.34 10.5 0.4 0.5 9.9 0.4 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) UPF0370 PF13980.6 EFA85702.1 - 1.7 8.8 0.0 1.7 8.8 0.0 3.1 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0370) DUF308 PF03729.13 EFA85702.1 - 2.3 8.6 40.4 0.057 13.8 17.5 2.7 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) YonK PF09642.10 EFA85703.1 - 0.12 12.5 6.2 5.2 7.3 0.1 4.1 4 0 0 4 4 4 0 YonK protein DUF3439 PF11921.8 EFA85703.1 - 0.28 11.2 6.7 0.65 10.0 6.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SapB_1 PF05184.15 EFA85704.1 - 8.9e-19 67.2 9.4 9e-10 38.4 0.7 3.8 3 1 0 3 3 3 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFA85704.1 - 3.5e-18 65.4 6.3 5.6e-10 39.2 0.8 2.9 2 0 0 2 2 2 2 Saposin-like type B, region 2 DUF445 PF04286.12 EFA85704.1 - 0.059 13.2 0.8 0.12 12.1 0.2 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF445) UCMA PF17085.5 EFA85704.1 - 6.9 6.7 6.7 3 7.8 3.6 2.0 2 1 1 3 3 3 0 Unique cartilage matrix associated protein Kelch_6 PF13964.6 EFA85705.1 - 1.9e-27 94.6 6.7 1.3e-08 34.8 0.2 5.2 5 1 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFA85705.1 - 3.4e-23 81.0 4.6 3.3e-10 39.4 0.1 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EFA85705.1 - 5.9e-22 77.4 4.9 1e-07 31.9 0.1 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA85705.1 - 3.6e-19 67.9 5.8 1.8e-06 27.7 0.1 5.3 4 1 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 EFA85705.1 - 2.3e-17 62.6 9.3 1.2e-05 25.2 0.3 4.7 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 EFA85705.1 - 1.2e-11 44.6 18.8 4.6e-05 23.6 0.1 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain BTB PF00651.31 EFA85705.1 - 1.1e-07 32.0 0.8 2.1e-05 24.7 0.1 2.7 1 1 1 2 2 2 1 BTB/POZ domain DUF3439 PF11921.8 EFA85705.1 - 0.012 15.6 9.1 0.027 14.4 9.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) BACK PF07707.15 EFA85705.1 - 0.079 13.1 0.2 0.26 11.4 0.0 1.9 2 0 0 2 2 2 0 BTB And C-terminal Kelch FBPase PF00316.20 EFA85707.1 - 5.3e-61 205.4 0.0 7.3e-61 204.9 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EFA85707.1 - 0.0018 17.9 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 Inositol monophosphatase family YqaH PF17448.2 EFA85707.1 - 0.031 14.6 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized YqaH-like Oxygenase-NA PF09859.9 EFA85707.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA RT_RNaseH_2 PF17919.1 EFA85708.1 - 6e-15 55.1 0.0 3.8e-14 52.5 0.0 2.4 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA85708.1 - 7.7e-13 48.6 0.0 3.4e-12 46.6 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase MOR2-PAG1_mid PF14228.6 EFA85709.1 - 6.3e-89 299.0 15.2 1.1e-38 132.6 2.9 3.2 1 1 1 3 3 3 3 Cell morphogenesis central region MOR2-PAG1_N PF14222.6 EFA85709.1 - 2e-82 278.0 0.6 4.5e-82 276.8 0.6 1.7 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EFA85709.1 - 1.4e-10 41.5 8.3 3.1e-09 37.1 2.0 4.9 3 1 0 3 3 3 1 Cell morphogenesis C-terminal Ank_2 PF12796.7 EFA85711.1 - 8.2e-31 106.4 13.0 2.8e-07 31.0 0.0 6.9 2 1 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85711.1 - 1.9e-24 85.7 12.6 3.7e-06 27.4 0.0 8.9 5 3 6 12 12 12 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85711.1 - 2.4e-21 75.5 10.2 0.017 15.4 0.0 12.0 6 2 7 13 13 13 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85711.1 - 2.5e-19 67.3 7.8 3.3 8.6 0.0 13.5 12 1 2 14 14 14 5 Ankyrin repeat DUF3447 PF11929.8 EFA85711.1 - 1.8e-05 24.6 24.7 0.031 14.2 0.1 7.2 2 2 4 7 7 7 4 Domain of unknown function (DUF3447) DUF899 PF05988.12 EFA85712.1 - 0.028 13.9 0.7 7.1 6.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF899) CENP-F_leu_zip PF10473.9 EFA85713.1 - 0.8 9.7 38.6 0.47 10.5 33.7 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 EFA85713.1 - 1.6 8.8 13.9 1.4 9.0 5.6 2.7 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Ank_2 PF12796.7 EFA85714.1 - 4.7e-31 107.2 12.1 8.7e-07 29.4 0.1 6.4 2 1 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA85714.1 - 2.2e-23 82.0 7.6 0.0029 17.9 0.0 11.6 6 2 6 12 12 12 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA85714.1 - 2.6e-22 78.9 10.2 9e-06 26.1 0.0 8.8 5 2 5 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85714.1 - 2.4e-18 64.3 5.5 3.2 8.6 0.0 13.1 13 1 1 14 14 14 4 Ankyrin repeat DUF3447 PF11929.8 EFA85714.1 - 8.9e-05 22.4 23.8 0.12 12.3 0.1 7.0 3 3 4 7 7 7 3 Domain of unknown function (DUF3447) DUF5049 PF16468.5 EFA85714.1 - 0.0041 17.0 7.3 45 4.0 0.0 7.0 9 1 1 10 10 10 0 Domain of unknown function (DUF5049) DUF4173 PF13777.6 EFA85715.1 - 0.0065 15.9 0.3 0.0077 15.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4173) PMP1_2 PF08114.11 EFA85715.1 - 0.18 11.6 2.0 0.41 10.4 0.2 2.3 2 0 0 2 2 2 0 ATPase proteolipid family WD40 PF00400.32 EFA85716.1 - 2e-36 123.3 25.4 5.8e-05 23.8 0.6 11.2 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85716.1 - 9.7e-13 48.2 3.2 0.0043 17.3 0.1 6.1 3 3 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain DUF5046 PF16465.5 EFA85716.1 - 0.002 17.6 1.1 0.21 11.0 0.0 3.1 1 1 1 3 3 3 1 Domain of unknown function (DUF5046) Ge1_WD40 PF16529.5 EFA85716.1 - 0.11 11.5 4.0 5.1 6.0 0.0 3.9 4 1 1 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFA85716.1 - 0.11 11.2 5.8 0.91 8.1 0.3 3.6 4 0 0 4 4 4 0 Nucleoporin Nup120/160 LIM PF00412.22 EFA85717.1 - 1e-10 41.6 9.5 2.2e-10 40.6 9.5 1.6 1 0 0 1 1 1 1 LIM domain zf-C3HC4_2 PF13923.6 EFA85717.1 - 0.84 9.5 6.5 11 6.0 0.2 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Abhydrolase_3 PF07859.13 EFA85718.1 - 2.8e-66 223.4 0.8 6.9e-66 222.1 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold FYVE PF01363.21 EFA85718.1 - 1.8e-21 76.0 10.0 6.8e-21 74.2 10.4 1.8 2 0 0 2 2 2 1 FYVE zinc finger COesterase PF00135.28 EFA85718.1 - 1.1e-10 41.0 0.3 3.9e-10 39.2 0.0 2.0 2 1 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 EFA85718.1 - 0.00056 19.5 1.4 0.0072 15.8 0.1 2.5 2 1 0 2 2 2 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 EFA85718.1 - 0.0017 17.3 0.0 0.0029 16.5 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase DLH PF01738.18 EFA85718.1 - 0.043 13.4 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Esterase_phd PF10503.9 EFA85718.1 - 0.056 12.9 0.3 2.4 7.6 0.3 2.3 1 1 0 1 1 1 0 Esterase PHB depolymerase AXE1 PF05448.12 EFA85718.1 - 0.061 12.0 0.0 0.15 10.7 0.0 1.6 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Macoilin PF09726.9 EFA85718.1 - 0.96 7.9 6.1 1.2 7.7 6.1 1.1 1 0 0 1 1 1 0 Macoilin family PhnA_Zn_Ribbon PF08274.12 EFA85718.1 - 1.2 9.1 5.6 4 7.5 5.6 1.9 1 1 0 1 1 1 0 PhnA Zinc-Ribbon zf-RING_5 PF14634.6 EFA85718.1 - 3.1 7.9 16.2 12 6.0 16.4 1.9 1 1 0 1 1 1 0 zinc-RING finger domain SOG2 PF10428.9 EFA85718.1 - 3.4 6.8 18.9 4.8 6.3 18.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein FYVE_2 PF02318.16 EFA85718.1 - 6 7.1 12.6 0.56 10.4 7.7 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger zf-RING_UBOX PF13445.6 EFA85718.1 - 6 7.0 11.7 1.7 8.7 8.2 2.0 2 0 0 2 2 2 0 RING-type zinc-finger ArfGap PF01412.18 EFA85719.1 - 2.5e-38 130.7 0.0 3.6e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 EFA85719.1 - 5.6e-19 68.6 0.3 9.5e-19 67.9 0.3 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFA85719.1 - 7.8e-06 26.3 2.3 0.00011 22.6 1.2 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EFA85719.1 - 0.00013 22.0 0.1 0.00024 21.2 0.1 1.3 1 0 0 1 1 1 1 PH domain MFS_1 PF07690.16 EFA85720.1 - 7.5e-40 136.9 44.8 7.3e-34 117.2 28.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFA85720.1 - 1.3e-11 44.0 25.3 2.9e-10 39.6 25.0 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter TerC PF03741.16 EFA85720.1 - 0.0049 16.6 0.6 0.0049 16.6 0.6 2.7 3 0 0 3 3 3 1 Integral membrane protein TerC family DUF872 PF05915.12 EFA85720.1 - 0.015 15.5 0.2 0.098 12.8 0.1 2.4 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) BatA PF07584.11 EFA85720.1 - 0.15 12.4 0.7 0.82 10.1 0.1 2.5 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal IMUP PF15761.5 EFA85720.1 - 7.1 7.4 8.4 13 6.5 8.4 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Myosin_head PF00063.21 EFA85721.1 - 4e-147 491.3 14.4 1e-97 328.0 5.8 2.3 1 1 1 2 2 2 2 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFA85721.1 - 9.5e-30 103.7 0.4 2.4e-29 102.4 0.4 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EFA85721.1 - 4.7e-07 29.0 0.9 4.7e-07 29.0 0.9 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_22 PF13401.6 EFA85721.1 - 0.0064 16.8 0.1 0.033 14.4 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EFA85721.1 - 0.0086 16.6 0.0 0.024 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFA85721.1 - 0.027 14.8 0.0 0.096 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain Corazonin PF17308.2 EFA85721.1 - 0.034 14.5 4.0 0.094 13.1 4.0 1.8 1 0 0 1 1 1 0 Pro-corazonin T2SSE PF00437.20 EFA85721.1 - 0.1 11.6 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein RabGAP-TBC PF00566.18 EFA85722.1 - 1e-31 110.3 5.0 1.9e-30 106.1 1.1 2.9 1 1 1 2 2 2 2 Rab-GTPase-TBC domain PH_RBD PF12068.8 EFA85722.1 - 5.1e-20 71.6 3.6 5.1e-20 71.6 3.6 3.2 2 1 0 2 2 2 1 Rab-binding domain (RBD) DUF3430 PF11912.8 EFA85723.1 - 0.38 10.8 0.0 0.38 10.8 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3430) Terpene_synth_C PF03936.16 EFA85725.1 - 0.0016 17.9 0.1 0.0032 16.8 0.1 1.5 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain TRI5 PF06330.11 EFA85725.1 - 0.0021 17.0 0.1 0.0036 16.2 0.1 1.4 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) Glycos_transf_2 PF00535.26 EFA85726.1 - 1.7e-22 80.0 2.1 2e-22 79.8 0.4 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFA85726.1 - 5.8e-08 32.9 0.0 1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 UFC1 PF08694.11 EFA85726.1 - 0.11 12.1 0.2 0.22 11.2 0.2 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 E1_DerP2_DerF2 PF02221.15 EFA85727.1 - 8.7e-07 29.4 0.0 9.4e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 ML domain C2 PF00168.30 EFA85728.1 - 1.9e-16 60.2 0.0 4.1e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain MMR1 PF08505.10 EFA85728.1 - 0.35 11.1 10.8 0.21 11.9 9.0 1.6 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein MRP-S26 PF14943.6 EFA85728.1 - 0.9 9.4 17.2 1.3 8.9 17.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Exonuc_VII_L PF02601.15 EFA85728.1 - 8.6 5.8 20.4 12 5.4 20.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Kelch_6 PF13964.6 EFA85729.1 - 3.6e-14 52.4 14.9 6.1e-07 29.5 0.0 5.7 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFA85729.1 - 1.5e-09 37.3 8.8 0.022 14.3 0.4 4.8 4 0 0 4 4 4 3 Kelch motif zf-B_box PF00643.24 EFA85729.1 - 1.8e-05 24.8 8.3 1.8e-05 24.8 8.3 1.9 2 0 0 2 2 2 1 B-box zinc finger Kelch_4 PF13418.6 EFA85729.1 - 2.2e-05 24.4 6.3 0.00012 22.0 0.0 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA85729.1 - 0.00017 21.4 10.7 0.012 15.6 0.0 5.5 6 0 0 6 6 6 1 Kelch motif Kelch_3 PF13415.6 EFA85729.1 - 0.007 16.6 0.4 6.4 7.2 0.0 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFA85729.1 - 0.2 11.7 0.1 0.2 11.7 0.1 5.1 6 0 0 6 6 6 0 Kelch motif CorA PF01544.18 EFA85729.1 - 0.41 9.9 4.1 0.38 10.0 2.3 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein HMG_CoA_synt_N PF01154.17 EFA85730.1 - 2.3e-91 304.4 0.2 4.6e-91 303.4 0.2 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 EFA85730.1 - 1.4e-83 280.7 1.1 2e-83 280.2 1.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Herpes_LMP1 PF05297.11 EFA85731.1 - 5.4 6.1 6.1 7.5 5.6 6.1 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) zf-MYND PF01753.18 EFA85734.1 - 8.7e-08 32.1 12.8 8.7e-08 32.1 12.8 1.9 2 0 0 2 2 2 1 MYND finger Ndc1_Nup PF09531.10 EFA85734.1 - 0.12 11.1 3.6 0.15 10.7 3.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mucin PF01456.17 EFA85734.1 - 0.21 11.5 17.5 0.35 10.8 17.5 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EFA85734.1 - 9 4.4 12.5 13 3.9 12.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Sel1 PF08238.12 EFA85735.1 - 4.1e-16 59.1 4.9 2.8e-09 37.3 0.4 5.8 6 0 0 6 6 6 2 Sel1 repeat TPR_16 PF13432.6 EFA85735.1 - 0.00073 20.1 5.5 0.0066 17.1 1.6 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA85735.1 - 0.026 15.3 2.0 22 6.2 0.1 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF4191 PF13829.6 EFA85735.1 - 0.11 11.8 0.8 0.19 11.0 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) TPR_8 PF13181.6 EFA85735.1 - 0.18 12.1 5.6 1 9.7 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA85735.1 - 0.27 11.7 3.1 33 5.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA85735.1 - 0.52 11.1 10.8 26 5.8 0.3 5.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85735.1 - 2.2 8.6 14.7 0.13 12.4 0.4 5.6 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA85735.1 - 7.6 6.5 11.1 6.1 6.8 0.3 5.3 6 1 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.12 EFA85736.1 - 1.8e-19 69.8 7.1 1.5e-09 38.2 0.5 6.3 6 0 0 6 6 6 4 Sel1 repeat zf-MYND PF01753.18 EFA85736.1 - 2.2e-07 30.8 12.8 6.3e-07 29.4 12.8 1.8 1 0 0 1 1 1 1 MYND finger TPR_16 PF13432.6 EFA85736.1 - 0.00047 20.7 0.3 0.013 16.1 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA85736.1 - 0.0072 16.9 13.5 9.3 7.1 0.0 6.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85736.1 - 0.046 13.9 20.8 0.34 11.1 0.1 6.7 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA85736.1 - 0.37 11.1 4.9 16 5.8 0.1 4.9 5 1 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA85736.1 - 1.4 9.0 7.1 7.5 6.7 0.2 3.6 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 EFA85736.1 - 3 8.3 11.9 0.99 9.8 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3439 PF11921.8 EFA85737.1 - 0.078 12.9 3.5 1.7 8.7 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF702 PF05142.12 EFA85737.1 - 1.5 9.3 12.2 4 7.9 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Mucin PF01456.17 EFA85737.1 - 2 8.4 16.0 1.6 8.7 9.0 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF1084 PF06454.11 EFA85738.1 - 1.8e-08 34.1 11.3 2.3e-08 33.7 11.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) EGF_2 PF07974.13 EFA85738.1 - 0.061 13.7 10.1 0.11 12.9 10.1 1.4 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 EFA85738.1 - 0.43 10.9 6.5 0.89 9.9 6.5 1.5 1 0 0 1 1 1 0 EB module EGF_Tenascin PF18720.1 EFA85738.1 - 0.47 10.6 6.2 0.87 9.7 6.2 1.4 1 0 0 1 1 1 0 Tenascin EGF domain VMA21 PF09446.10 EFA85738.1 - 0.5 10.5 7.3 1.3 9.2 0.9 2.7 2 0 0 2 2 2 0 VMA21-like domain Nup54 PF13874.6 EFA85740.1 - 6.2e-31 107.4 1.3 1.1e-30 106.6 1.3 1.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 EFA85740.1 - 3.4e-18 66.3 83.5 3.5e-07 31.0 26.1 3.4 1 1 2 3 3 3 3 Nucleoporin FG repeat region Ank_2 PF12796.7 EFA85741.1 - 2.1e-21 76.3 1.7 2.3e-05 24.9 0.0 5.7 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA85741.1 - 5.5e-11 41.7 1.3 4 8.3 0.0 9.5 11 0 0 11 11 11 2 Ankyrin repeat Ank_4 PF13637.6 EFA85741.1 - 6.6e-11 42.5 4.3 0.64 10.7 0.0 7.5 5 3 3 8 8 8 5 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFA85741.1 - 1e-06 28.5 0.4 0.43 10.5 0.0 5.2 5 1 1 6 6 6 2 Domain of unknown function (DUF5049) Ank_5 PF13857.6 EFA85741.1 - 2.3e-06 27.8 0.0 4 7.9 0.0 6.3 5 2 3 8 8 8 1 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA85741.1 - 0.00051 19.9 1.1 0.00051 19.9 1.1 6.1 3 1 4 7 7 7 1 Domain of unknown function (DUF3447) Ndc80_HEC PF03801.13 EFA85741.1 - 0.024 14.2 0.1 1.3 8.6 0.1 2.9 2 0 0 2 2 2 0 HEC/Ndc80p family FBD PF08387.10 EFA85741.1 - 0.35 10.8 1.6 11 6.0 0.0 4.1 5 1 0 5 5 5 0 FBD EGF PF00008.27 EFA85742.1 - 0.029 14.7 2.4 0.029 14.7 2.4 6.3 7 1 0 7 7 7 0 EGF-like domain RsgA_GTPase PF03193.16 EFA85743.1 - 0.00046 20.1 0.1 0.051 13.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_PrkA PF08298.11 EFA85743.1 - 0.0044 16.0 0.0 0.0077 15.2 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain MMR_HSR1 PF01926.23 EFA85743.1 - 0.0067 16.5 0.0 0.023 14.7 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFA85743.1 - 0.016 14.7 0.0 0.04 13.3 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.19 EFA85743.1 - 0.023 14.3 0.1 0.35 10.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EFA85743.1 - 0.025 14.3 1.2 1.6 8.5 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EFA85743.1 - 0.026 14.0 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EFA85743.1 - 0.028 14.3 5.0 0.043 13.7 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EFA85743.1 - 0.033 14.7 0.0 0.096 13.2 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EFA85743.1 - 0.045 13.5 0.0 0.095 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 EFA85743.1 - 0.081 12.4 0.5 1.1 8.7 0.1 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EFA85743.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA85743.1 - 0.11 12.9 0.0 0.37 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EFA85743.1 - 1.5 9.3 7.5 0.29 11.6 0.3 2.8 2 2 0 2 2 2 0 AAA domain TIG PF01833.24 EFA85744.1 - 6.3e-15 55.0 48.0 4.5e-06 26.7 2.2 5.9 5 0 0 5 5 5 4 IPT/TIG domain EGF_2 PF07974.13 EFA85744.1 - 0.00028 21.2 12.0 0.00067 20.0 12.0 1.7 1 0 0 1 1 1 1 EGF-like domain EB PF01683.18 EFA85744.1 - 0.032 14.5 3.6 0.077 13.3 3.6 1.5 1 0 0 1 1 1 0 EB module Epiglycanin_C PF14654.6 EFA85744.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region EGF_Tenascin PF18720.1 EFA85744.1 - 0.53 10.4 5.9 1.1 9.3 5.9 1.6 1 0 0 1 1 1 0 Tenascin EGF domain I-EGF_1 PF18372.1 EFA85744.1 - 2.7 8.2 9.1 6.5 6.9 9.1 1.6 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 NT-C2 PF10358.9 EFA85745.1 - 7.6e-20 71.1 3.2 2.2e-19 69.6 3.2 1.8 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EFA85745.1 - 3.1e-18 65.9 3.4 3.1e-18 65.9 3.4 2.4 2 0 0 2 2 2 1 DIL domain ABC_tran_CTD PF16326.5 EFA85745.1 - 0.0072 16.6 1.7 0.0072 16.6 1.7 5.1 5 1 0 5 5 5 1 ABC transporter C-terminal domain ADIP PF11559.8 EFA85745.1 - 0.015 15.4 21.0 0.16 12.0 6.1 2.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EFA85745.1 - 0.48 10.6 35.4 0.22 11.7 11.8 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) GAS PF13851.6 EFA85745.1 - 0.63 9.4 39.9 0.07 12.5 12.9 3.5 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 EFA85745.1 - 0.7 9.2 20.6 0.13 11.6 5.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DS PF01916.17 EFA85746.1 - 5.7e-132 439.3 0.0 6.6e-132 439.1 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase SIT PF15330.6 EFA85747.1 - 0.11 12.9 1.5 0.27 11.7 1.5 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF1077 PF06417.12 EFA85748.1 - 4e-37 126.8 2.0 5.9e-37 126.3 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) DUF3789 PF12664.7 EFA85748.1 - 0.2 11.4 1.0 0.42 10.4 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) ThiS PF02597.20 EFA85749.1 - 2.6e-13 50.4 0.0 3.4e-13 50.0 0.0 1.3 1 1 0 1 1 1 1 ThiS family DUF1373 PF07117.11 EFA85750.1 - 0.068 13.2 7.5 0.099 12.6 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1373) PS_Dcarbxylase PF02666.15 EFA85751.1 - 3.3e-64 216.1 0.0 3.9e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase PsaF PF17550.2 EFA85751.1 - 0.12 11.9 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function SH3_17 PF18350.1 EFA85751.1 - 0.16 11.8 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease SH3 domain FNIP PF05725.12 EFA85753.1 - 7.6e-43 144.4 25.8 3.8e-13 49.4 1.4 5.7 6 0 0 6 6 6 5 FNIP Repeat F-box PF00646.33 EFA85753.1 - 0.024 14.5 0.1 0.057 13.3 0.1 1.7 1 0 0 1 1 1 0 F-box domain SnoaL_2 PF12680.7 EFA85754.1 - 1.1e-05 26.0 0.0 1.2e-05 25.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EFA85754.1 - 0.004 16.9 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DUF4440 PF14534.6 EFA85754.1 - 0.03 14.7 0.0 0.031 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) FAD_binding_3 PF01494.19 EFA85755.1 - 0.00023 20.6 0.0 0.00064 19.1 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain ThuA PF06283.11 EFA85755.1 - 0.047 13.9 0.0 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 Trehalose utilisation Pyr_redox_2 PF07992.14 EFA85755.1 - 0.16 11.2 0.1 0.57 9.4 0.1 1.6 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CUE PF02845.16 EFA85757.1 - 5.5e-05 22.8 0.3 0.0037 16.9 0.0 3.5 4 1 0 4 4 4 1 CUE domain UBA_4 PF14555.6 EFA85757.1 - 0.17 11.8 3.6 4.3 7.2 0.2 3.0 3 0 0 3 3 3 0 UBA-like domain Vault PF01505.18 EFA85758.1 - 3.9e-56 187.0 0.7 5.4e-13 48.9 0.0 5.0 5 0 0 5 5 5 4 Major Vault Protein repeat domain Vault_2 PF17794.1 EFA85758.1 - 1.2e-27 96.0 0.8 3e-23 82.0 0.1 2.6 2 0 0 2 2 2 2 Major Vault Protein repeat domain Vault_3 PF17795.1 EFA85758.1 - 0.057 13.5 0.0 2.5 8.2 0.0 2.7 2 0 0 2 2 2 0 Major Vault Protein Repeat domain NTP_transf_2 PF01909.23 EFA85759.1 - 3.1e-07 30.6 0.0 8.5e-07 29.2 0.0 1.8 1 1 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EFA85759.1 - 1.2e-05 25.4 0.5 1.2e-05 25.4 0.5 3.1 4 0 0 4 4 4 1 Cid1 family poly A polymerase Polbeta PF18765.1 EFA85759.1 - 0.00058 19.9 0.0 0.0022 18.0 0.0 2.1 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase cobW PF02492.19 EFA85760.1 - 6.1e-55 185.5 2.3 6.1e-55 185.5 2.3 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFA85760.1 - 4e-23 81.2 0.0 7.7e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain CDC45 PF02724.14 EFA85760.1 - 6.6e-06 24.7 11.0 6.6e-06 24.7 11.0 1.7 1 1 0 1 1 1 1 CDC45-like protein MobB PF03205.14 EFA85760.1 - 0.00054 19.9 0.3 0.018 15.0 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 EFA85760.1 - 0.0016 18.0 1.5 0.25 10.8 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA85760.1 - 0.0054 16.7 6.1 0.065 13.1 0.2 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_16 PF13191.6 EFA85760.1 - 0.011 16.1 0.4 0.045 14.1 0.1 2.3 2 1 0 2 2 2 0 AAA ATPase domain TsaE PF02367.17 EFA85760.1 - 0.023 14.7 0.1 0.06 13.4 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 EFA85760.1 - 0.03 14.0 1.7 0.044 13.5 0.0 2.1 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EFA85760.1 - 0.036 13.1 0.0 0.087 11.9 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EFA85760.1 - 0.056 13.5 0.3 0.056 13.5 0.3 2.5 3 1 0 3 3 3 0 50S ribosome-binding GTPase NACHT PF05729.12 EFA85760.1 - 0.13 12.2 0.5 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 NACHT domain MeaB PF03308.16 EFA85760.1 - 0.22 10.5 0.3 0.84 8.6 0.0 2.1 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFA85760.1 - 0.59 10.7 0.0 0.59 10.7 0.0 2.6 2 1 0 2 2 1 0 ABC transporter Nop14 PF04147.12 EFA85760.1 - 5.2 5.1 34.7 0.022 13.0 25.3 1.7 2 0 0 2 2 2 0 Nop14-like family Roughex PF06020.11 EFA85760.1 - 5.4 6.0 11.7 11 5.0 11.7 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Ubie_methyltran PF01209.18 EFA85761.1 - 9.1e-22 77.5 0.0 2.9e-21 75.9 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFA85761.1 - 1.4e-19 70.5 0.0 3.7e-19 69.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA85761.1 - 2e-19 70.0 0.0 3.5e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA85761.1 - 3e-17 62.8 0.0 4.4e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA85761.1 - 1.4e-11 44.5 0.0 2.5e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA85761.1 - 1.6e-11 44.8 0.0 2.7e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA85761.1 - 0.00051 19.5 0.0 0.00067 19.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EFA85761.1 - 0.0011 18.3 0.0 0.0017 17.7 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EFA85761.1 - 0.0024 17.4 0.0 0.014 14.9 0.0 2.2 1 1 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EFA85761.1 - 0.031 13.8 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EFA85761.1 - 0.08 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CBS PF00571.28 EFA85762.1 - 9.8e-20 70.8 6.7 2e-05 25.0 0.0 4.3 4 0 0 4 4 4 4 CBS domain SoDot-IcmSS PF16848.5 EFA85762.1 - 0.017 15.1 0.6 0.16 11.9 0.1 2.4 2 0 0 2 2 2 0 Substrate of the Dot/Icm secretion system, putative BNR_2 PF13088.6 EFA85763.1 - 1.5e-05 24.5 0.2 2.3e-05 23.8 0.1 1.4 2 0 0 2 2 2 1 BNR repeat-like domain Glyco_hydro_43 PF04616.14 EFA85763.1 - 0.0061 15.9 0.4 1.5 8.1 0.1 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 BNR_4 PF15892.5 EFA85763.1 - 0.014 14.7 0.1 1.9 7.8 0.0 2.3 2 0 0 2 2 2 0 BNR repeat-containing family member CfAFP PF05264.11 EFA85764.1 - 0.18 11.8 1.9 0.28 11.2 1.1 1.9 1 1 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) Kelch_1 PF01344.25 EFA85764.1 - 9.2 5.9 10.5 8.9 6.0 0.0 4.5 5 0 0 5 5 5 0 Kelch motif Aminotran_5 PF00266.19 EFA85765.1 - 2.4e-88 296.6 0.0 3.5e-88 296.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFA85765.1 - 1.7e-08 34.1 0.1 5.2e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EFA85765.1 - 8.6e-08 31.9 0.0 1.4e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family H_lectin PF09458.10 EFA85765.1 - 0.092 13.0 0.0 0.29 11.4 0.0 1.9 1 0 0 1 1 1 0 H-type lectin domain F-box-like PF12937.7 EFA85765.1 - 0.15 12.0 0.0 0.63 10.0 0.0 2.1 1 0 0 1 1 1 0 F-box-like Med6 PF04934.14 EFA85767.1 - 3.3e-40 137.0 1.7 3.3e-40 137.0 1.7 1.5 2 0 0 2 2 2 1 MED6 mediator sub complex component DUF711 PF05167.12 EFA85767.1 - 0.16 10.9 0.1 0.19 10.6 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) SnoaL_2 PF12680.7 EFA85768.1 - 2.5e-05 24.8 0.0 2.8e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EFA85768.1 - 0.0037 17.1 0.0 0.0043 16.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DUF4440 PF14534.6 EFA85768.1 - 0.053 13.9 0.0 0.057 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) PRIMA1 PF16101.5 EFA85769.1 - 0.16 12.0 5.1 3.5 7.7 0.4 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 UIM PF02809.20 EFA85769.1 - 4.7 7.4 9.2 0.093 12.7 1.5 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Romo1 PF10247.9 EFA85770.1 - 0.00016 22.0 1.1 0.00047 20.5 0.4 2.1 2 0 0 2 2 2 1 Reactive mitochondrial oxygen species modulator 1 SNAPc_SNAP43 PF09808.9 EFA85770.1 - 0.088 12.7 0.4 0.22 11.4 0.1 1.7 2 0 0 2 2 2 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 TMEM154 PF15102.6 EFA85770.1 - 0.44 10.5 1.6 2.6 8.0 0.0 3.0 2 0 0 2 2 2 0 TMEM154 protein family Oxysterol_BP PF01237.18 EFA85771.1 - 3.4e-57 194.0 4.5 3.2e-56 190.8 4.5 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Protocadherin PF08374.11 EFA85772.1 - 0.59 10.1 5.1 0.24 11.3 1.6 2.1 2 0 0 2 2 2 0 Protocadherin Polyketide_cyc2 PF10604.9 EFA85773.1 - 2.1e-07 31.3 0.1 2.9e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Kelch_1 PF01344.25 EFA85774.1 - 0.76 9.4 5.2 8.9 6.0 0.0 3.8 4 0 0 4 4 4 0 Kelch motif BNR_2 PF13088.6 EFA85775.1 - 1.8e-05 24.2 0.2 3.3e-05 23.3 0.1 1.5 2 0 0 2 2 2 1 BNR repeat-like domain Glyco_hydro_43 PF04616.14 EFA85775.1 - 0.0053 16.1 0.4 1.3 8.2 0.1 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 BNR_4 PF15892.5 EFA85775.1 - 0.01 15.2 0.1 1.5 8.1 0.0 2.3 2 0 0 2 2 2 0 BNR repeat-containing family member Metallophos PF00149.28 EFA85776.1 - 5e-33 115.3 0.0 9.5e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 EFA85776.1 - 0.011 15.1 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Macoilin PF09726.9 EFA85776.1 - 0.057 12.0 32.9 0.085 11.4 32.9 1.2 1 0 0 1 1 1 0 Macoilin family Glyco_transf_8 PF01501.20 EFA85777.1 - 1.7e-05 24.5 0.2 1.7e-05 24.5 0.2 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 8 DUF4834 PF16118.5 EFA85777.1 - 0.0074 17.2 1.1 0.015 16.3 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DHHW PF14286.6 EFA85777.1 - 0.022 14.1 7.0 0.042 13.2 7.0 1.4 1 0 0 1 1 1 0 DHHW protein Sec61_beta PF03911.16 EFA85777.1 - 0.15 12.1 0.9 0.28 11.3 0.9 1.5 1 0 0 1 1 1 0 Sec61beta family ABC2_membrane_3 PF12698.7 EFA85777.1 - 0.89 8.6 3.3 1.1 8.3 3.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein dsRBD2 PF17842.1 EFA85777.1 - 3 8.0 6.7 4.8 7.4 6.7 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Sec62 PF03839.16 EFA85777.1 - 4.3 6.8 5.5 7.5 6.0 5.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Pantoate_transf PF02548.15 EFA85778.1 - 9.2e-114 379.2 0.4 1.6e-113 378.4 0.4 1.4 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase ApbA_C PF08546.11 EFA85778.1 - 9.1e-27 93.7 0.0 2.2e-26 92.5 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFA85778.1 - 8.9e-16 57.9 0.2 3.6e-08 33.2 0.0 2.9 1 1 1 2 2 2 2 Ketopantoate reductase PanE/ApbA PhyH PF05721.13 EFA85778.1 - 2.3e-13 50.9 0.0 5.9e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PEP_mutase PF13714.6 EFA85778.1 - 0.0051 16.3 0.0 0.014 14.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Shikimate_DH PF01488.20 EFA85778.1 - 0.055 13.5 0.1 0.29 11.2 0.0 2.1 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase ATP-synt_E PF05680.12 EFA85778.1 - 1.1 9.6 4.6 2.7 8.4 4.6 1.6 1 0 0 1 1 1 0 ATP synthase E chain Tristanin_u2 PF16638.5 EFA85778.1 - 1.6 9.5 5.6 4.9 8.0 5.6 1.8 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Ank_2 PF12796.7 EFA85779.1 - 0.0092 16.5 2.3 34 5.1 0.1 5.2 3 1 3 6 6 6 3 Ankyrin repeats (3 copies) Fez1 PF06818.15 EFA85780.1 - 0.0022 18.5 3.5 0.0022 18.5 3.5 1.8 2 0 0 2 2 2 1 Fez1 Csm1_N PF18504.1 EFA85780.1 - 0.0025 18.1 6.3 0.0025 18.1 6.3 2.0 1 1 1 2 2 2 1 Csm1 N-terminal domain Tup_N PF08581.10 EFA85780.1 - 0.0035 17.6 9.4 0.0063 16.8 9.4 1.4 1 0 0 1 1 1 1 Tup N-terminal HOOK PF05622.12 EFA85780.1 - 0.019 13.1 4.7 0.027 12.6 4.7 1.1 1 0 0 1 1 1 0 HOOK protein TMF_DNA_bd PF12329.8 EFA85780.1 - 0.029 14.4 3.7 0.029 14.4 3.7 2.9 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.14 EFA85780.1 - 0.036 13.9 2.5 0.066 13.0 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) bZIP_1 PF00170.21 EFA85780.1 - 0.053 13.6 6.4 0.057 13.5 0.4 2.4 2 0 0 2 2 2 0 bZIP transcription factor Utp14 PF04615.13 EFA85780.1 - 0.065 11.8 13.9 0.077 11.6 13.9 1.0 1 0 0 1 1 1 0 Utp14 protein DUF641 PF04859.12 EFA85780.1 - 0.078 13.3 4.1 0.15 12.4 4.1 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) APG6_N PF17675.1 EFA85780.1 - 0.083 13.4 5.6 0.15 12.6 5.6 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region bZIP_2 PF07716.15 EFA85780.1 - 0.19 11.8 11.6 0.21 11.7 0.8 2.5 2 0 0 2 2 2 0 Basic region leucine zipper Tmemb_cc2 PF10267.9 EFA85780.1 - 0.22 10.6 23.2 0.38 9.8 23.2 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF3450 PF11932.8 EFA85780.1 - 0.76 9.0 6.0 1.3 8.2 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PKcGMP_CC PF16808.5 EFA85780.1 - 5 7.1 11.3 3 7.8 0.4 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DivIC PF04977.15 EFA85780.1 - 9.9 6.0 8.9 3.9 7.3 1.0 2.3 1 1 1 2 2 2 0 Septum formation initiator RhoGEF PF00621.20 EFA85781.1 - 1.1e-48 165.9 2.5 1.1e-48 165.9 2.5 2.3 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EFA85781.1 - 2.6e-19 69.1 10.4 4.8e-19 68.3 10.4 1.4 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EFA85781.1 - 3e-11 43.7 0.6 6.6e-11 42.7 0.6 1.6 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.16 EFA85781.1 - 0.00063 20.0 6.8 0.0014 18.8 6.8 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 EFA85781.1 - 0.0054 16.6 0.5 0.011 15.5 0.5 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFA85781.1 - 0.015 15.7 0.8 0.074 13.5 0.8 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain DUF4108 PF13390.6 EFA85781.1 - 0.025 14.5 1.8 0.087 12.7 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4108) PH_3 PF14593.6 EFA85781.1 - 0.071 13.2 1.4 1.7 8.8 1.4 2.4 1 1 0 1 1 1 0 PH domain SRF-TF PF00319.18 EFA85782.1 - 7e-14 51.0 0.0 1.5e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) AOX PF01786.17 EFA85783.1 - 2.6e-77 259.3 1.1 3.5e-77 258.8 1.1 1.1 1 0 0 1 1 1 1 Alternative oxidase COQ7 PF03232.13 EFA85783.1 - 0.019 14.8 0.1 0.019 14.8 0.1 2.1 1 1 1 2 2 2 0 Ubiquinone biosynthesis protein COQ7 pRN1_helical PF13010.6 EFA85785.1 - 0.31 11.0 5.0 0.19 11.7 2.2 2.1 2 0 0 2 2 2 0 Primase helical domain Troponin PF00992.20 EFA85785.1 - 0.37 11.1 16.8 0.52 10.6 3.7 2.8 2 1 0 2 2 2 0 Troponin Ifi-6-16 PF06140.13 EFA85786.1 - 2.9e-08 33.5 22.5 3.9e-08 33.1 22.1 1.4 1 1 0 1 1 1 1 Interferon-induced 6-16 family Reticulon PF02453.17 EFA85788.1 - 0.19 11.7 0.1 0.19 11.7 0.1 3.9 3 1 1 4 4 4 0 Reticulon ABC_membrane_2 PF06472.15 EFA85789.1 - 2.3e-48 164.9 3.9 2.3e-48 164.9 3.9 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFA85789.1 - 1.8e-15 57.7 0.0 6.8e-15 55.8 0.0 2.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFA85789.1 - 0.0013 18.4 0.2 0.0032 17.2 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA85789.1 - 0.0028 18.1 0.0 0.0078 16.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EFA85789.1 - 0.0064 16.3 0.2 0.0064 16.3 0.2 1.8 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA85789.1 - 0.0082 15.6 0.6 2.3 7.6 0.1 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFA85789.1 - 0.013 15.4 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Sigma54_activat PF00158.26 EFA85789.1 - 0.05 13.3 0.0 0.94 9.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 EFA85789.1 - 0.07 13.4 0.1 0.24 11.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain TraL PF07178.11 EFA85789.1 - 0.3 11.6 4.1 4.4 7.8 0.6 3.1 2 1 1 3 3 3 0 TraL protein Cytidylate_kin PF02224.18 EFA85789.1 - 0.44 10.3 5.8 5 6.8 0.0 3.5 4 0 0 4 4 4 0 Cytidylate kinase AAA_23 PF13476.6 EFA85789.1 - 2 8.8 9.3 0.72 10.3 1.5 3.0 1 1 0 2 2 2 0 AAA domain RNA_pol_A_bac PF01000.26 EFA85790.1 - 3.7e-33 114.2 0.1 1.8e-32 112.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFA85790.1 - 2.9e-23 81.0 0.0 3.9e-23 80.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain ETF_QO PF05187.13 EFA85790.1 - 0.0053 16.9 0.9 0.014 15.5 0.9 1.8 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_7 PF12838.7 EFA85790.1 - 0.8 10.3 9.7 0.091 13.4 3.4 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFA85790.1 - 3.4 7.9 12.4 0.19 11.9 3.3 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain SQS_PSY PF00494.19 EFA85791.1 - 5.7e-44 150.6 0.1 7.2e-44 150.3 0.1 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase SelP_N PF04592.14 EFA85791.1 - 0.083 12.3 9.8 0.13 11.6 9.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region WD40 PF00400.32 EFA85792.1 - 2.7e-18 66.0 18.3 0.021 15.7 0.0 9.9 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85792.1 - 1.5e-08 34.8 0.0 1.1 9.5 0.0 6.8 8 0 0 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA85792.1 - 0.023 14.0 0.4 1.4 8.1 0.0 3.5 5 0 0 5 5 5 0 WD40-like domain Mucin PF01456.17 EFA85792.1 - 0.55 10.2 28.3 1.5 8.8 28.3 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein SUIM_assoc PF16619.5 EFA85792.1 - 0.6 10.2 21.0 0.64 10.1 1.2 3.5 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF4512 PF14975.6 EFA85792.1 - 5.2 7.9 10.5 54 4.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Copine PF07002.16 EFA85793.1 - 9.9e-66 221.3 0.0 1.2e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFA85793.1 - 4.3e-11 43.3 0.1 6.6e-11 42.7 0.1 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF2828 PF11443.8 EFA85796.1 - 0.0072 14.5 14.8 0.0081 14.3 14.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) CDC45 PF02724.14 EFA85796.1 - 0.009 14.4 19.5 0.01 14.1 19.5 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF2151 PF10221.9 EFA85796.1 - 0.013 14.2 19.4 0.014 14.0 19.4 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF913 PF06025.12 EFA85796.1 - 0.039 12.9 6.9 0.055 12.5 6.9 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SLC12 PF03522.15 EFA85796.1 - 0.064 12.3 19.3 0.074 12.1 19.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RP-C_C PF11800.8 EFA85796.1 - 0.16 12.0 7.0 0.21 11.6 7.0 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Sec62 PF03839.16 EFA85796.1 - 0.28 10.7 26.0 0.38 10.2 26.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 AAA_11 PF13086.6 EFA85796.1 - 0.4 10.4 18.0 0.5 10.1 18.0 1.3 1 0 0 1 1 1 0 AAA domain DUF789 PF05623.12 EFA85796.1 - 0.46 10.1 12.5 0.7 9.5 12.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Presenilin PF01080.17 EFA85796.1 - 0.61 8.8 20.6 0.79 8.4 20.6 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 EFA85796.1 - 0.82 8.0 11.1 0.87 7.9 11.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 EFA85796.1 - 0.93 9.5 11.8 1.1 9.2 11.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paramyxo_ncap PF00973.19 EFA85796.1 - 1.1 8.1 12.4 1.2 8.0 12.4 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein GPCR_chapero_1 PF11904.8 EFA85796.1 - 1.2 8.5 21.6 1.7 8.0 21.6 1.4 1 1 0 1 1 1 0 GPCR-chaperone HCO3_cotransp PF00955.21 EFA85796.1 - 1.6 7.4 4.8 2 7.2 4.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family ALMT PF11744.8 EFA85796.1 - 1.7 7.4 16.4 2 7.2 16.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 EFA85796.1 - 1.9 7.4 11.3 2.5 7.0 11.3 1.2 1 0 0 1 1 1 0 CLN3 protein GAGA_bind PF06217.12 EFA85796.1 - 2.8 8.1 21.4 4.6 7.4 21.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4604 PF15377.6 EFA85796.1 - 4 7.8 34.1 6.1 7.2 34.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Zip PF02535.22 EFA85796.1 - 4.1 6.5 12.5 5.2 6.2 12.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Membralin PF09746.9 EFA85796.1 - 5.2 6.0 15.3 6.6 5.7 15.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF5470 PF17564.2 EFA85797.1 - 0.091 13.0 1.0 0.14 12.4 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5470) WD40 PF00400.32 EFA85798.1 - 3.3e-06 27.7 0.1 0.00043 21.0 0.0 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat Peptidase_C97 PF05903.14 EFA85799.1 - 0.097 12.5 0.1 0.44 10.4 0.1 1.9 2 0 0 2 2 2 0 PPPDE putative peptidase domain zf-BED PF02892.15 EFA85799.1 - 0.11 12.5 2.1 2.6 8.1 1.9 2.3 2 0 0 2 2 2 0 BED zinc finger Metallophos PF00149.28 EFA85800.1 - 3.3e-14 53.9 1.9 5.6e-14 53.1 1.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA85800.1 - 0.00017 21.8 0.2 0.0037 17.5 0.2 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EFA85800.1 - 0.035 13.4 0.1 0.26 10.6 0.0 2.2 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily FapA PF03961.13 EFA85800.1 - 0.056 12.0 6.6 0.1 11.2 6.6 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3213 PF11491.8 EFA85800.1 - 0.73 10.1 5.1 0.47 10.7 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3213) FlaC_arch PF05377.11 EFA85800.1 - 2.7 8.4 9.3 7.7 7.0 1.3 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF902 PF06001.13 EFA85801.1 - 0.055 14.0 2.7 0.055 14.0 2.7 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF902) HSV_VP16_C PF12149.8 EFA85801.1 - 0.077 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal COPIIcoated_ERV PF07970.12 EFA85803.1 - 9.9e-82 274.1 0.8 1.8e-81 273.2 0.8 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFA85803.1 - 1.1e-31 109.0 3.0 3.1e-31 107.6 0.4 2.3 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PWWP PF00855.17 EFA85804.1 - 2.9e-09 37.2 0.3 2.9e-09 37.2 0.3 3.1 4 1 0 4 4 4 1 PWWP domain zf-SAP30 PF13866.6 EFA85805.1 - 0.08 13.1 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 SAP30 zinc-finger SNAPc_SNAP43 PF09808.9 EFA85807.1 - 8.6e-34 117.1 0.0 8.6e-34 117.1 0.0 2.1 2 0 0 2 2 2 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Dickkopf_N PF04706.12 EFA85808.1 - 0.00069 20.0 5.1 0.00069 20.0 5.1 7.6 4 3 2 7 7 7 2 Dickkopf N-terminal cysteine-rich region TGT PF01702.18 EFA85809.1 - 1.2e-141 472.0 0.0 1.6e-141 471.6 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DEAD PF00270.29 EFA85810.1 - 7.6e-43 146.3 0.3 1.3e-42 145.6 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA85810.1 - 1.6e-27 96.1 0.6 1.1e-26 93.3 0.5 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ank_2 PF12796.7 EFA85810.1 - 1.4e-09 38.4 0.5 5.6e-05 23.7 0.1 3.8 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA85810.1 - 7.5e-07 29.6 0.2 0.0042 17.6 0.0 4.6 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA85810.1 - 4.9e-06 26.7 0.1 0.52 10.7 0.0 4.6 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85810.1 - 0.031 14.8 0.0 43 5.1 0.0 5.1 5 0 0 5 5 5 0 Ankyrin repeat BBS2_N PF14781.6 EFA85812.1 - 0.049 13.5 1.3 0.34 10.8 0.5 2.5 1 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal ANAPC4_WD40 PF12894.7 EFA85812.1 - 0.05 13.9 0.1 0.62 10.4 0.1 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2718 PF10918.8 EFA85812.1 - 0.079 13.5 1.8 2.3 8.7 0.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2718) Nucleoporin_FG PF13634.6 EFA85813.1 - 2.7e-14 53.8 340.2 0.00037 21.3 21.6 15.1 3 3 10 13 13 13 9 Nucleoporin FG repeat region DUF5446 PF17522.2 EFA85813.1 - 0.039 14.1 0.3 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Lyase_catalyt PF09093.11 EFA85813.1 - 0.052 12.7 0.7 0.086 12.0 0.7 1.2 1 0 0 1 1 1 0 Lyase, catalytic DUF1664 PF07889.12 EFA85813.1 - 0.12 12.4 8.2 0.026 14.5 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Mu-like_Com PF10122.9 EFA85814.1 - 0.029 13.8 0.1 12 5.4 0.0 2.5 2 0 0 2 2 2 0 Mu-like prophage protein Com Rhabdo_ncap PF00945.18 EFA85814.1 - 3.1 6.6 7.9 4.3 6.1 0.3 3.1 3 0 0 3 3 3 0 Rhabdovirus nucleocapsid protein HSA PF07529.13 EFA85815.1 - 1.1 9.6 7.0 0.88 9.9 0.1 3.6 3 1 1 4 4 4 0 HSA DUF5327 PF17261.2 EFA85815.1 - 4.9 8.0 7.3 0.86 10.4 2.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Chorion_2 PF03964.15 EFA85817.1 - 7.7 7.4 15.2 0.95 10.3 3.1 3.7 3 0 0 3 3 3 0 Chorion family 2 FH2 PF02181.23 EFA85818.1 - 3.3e-49 168.0 2.8 3.3e-49 168.0 2.8 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFA85818.1 - 2.7e-24 85.8 0.2 6.9e-24 84.5 0.2 1.7 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFA85818.1 - 2.4e-23 82.8 1.3 5.1e-23 81.7 1.3 1.6 1 0 0 1 1 1 1 Diaphanous FH3 Domain Leu_zip PF15294.6 EFA85818.1 - 0.0096 15.5 5.0 0.02 14.4 5.0 1.5 1 0 0 1 1 1 1 Leucine zipper TolA_bind_tri PF16331.5 EFA85818.1 - 0.027 14.5 1.5 8 6.6 0.2 2.9 2 1 1 3 3 3 0 TolA binding protein trimerisation DUF3361 PF11841.8 EFA85818.1 - 0.045 13.7 0.2 0.35 10.8 0.2 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3361) CCDC-167 PF15188.6 EFA85818.1 - 0.71 10.3 2.8 2.9 8.3 2.8 2.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 EFA85818.1 - 1.3 9.0 7.6 15 5.7 5.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EFA85818.1 - 1.6 8.8 5.4 4.6 7.3 0.8 2.6 1 1 1 2 2 2 0 Laminin Domain II Phage_Integr_2 PF13009.6 EFA85820.1 - 0.071 12.2 0.2 0.09 11.9 0.2 1.2 1 0 0 1 1 1 0 Putative phage integrase Exo_endo_phos PF03372.23 EFA85821.1 - 8.6e-11 41.8 0.3 2.3e-10 40.4 0.3 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Hira PF07569.11 EFA85822.1 - 0.035 13.8 0.3 0.038 13.7 0.3 1.0 1 0 0 1 1 1 0 TUP1-like enhancer of split Ammonium_transp PF00909.21 EFA85823.1 - 1.6e-53 181.9 17.5 2.3e-53 181.4 17.5 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family COX2_TM PF02790.15 EFA85823.1 - 0.031 14.4 0.1 2.2 8.5 0.1 2.9 1 1 1 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain Kinocilin PF15033.6 EFA85823.1 - 0.056 13.1 0.9 0.13 11.9 0.2 2.1 2 0 0 2 2 2 0 Kinocilin protein RasGEF PF00617.19 EFA85824.1 - 4.7e-42 144.2 1.6 4.7e-42 144.2 1.6 3.2 2 2 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFA85824.1 - 5.8e-22 77.9 0.9 5.8e-22 77.9 0.9 4.2 3 1 0 3 3 3 1 RasGEF N-terminal motif DEP PF00610.21 EFA85824.1 - 4.4e-13 49.1 0.3 1.7e-12 47.2 0.0 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF5395 PF17373.2 EFA85824.1 - 0.079 13.6 0.1 0.27 11.9 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5395) Pkinase PF00069.25 EFA85826.1 - 3.8e-40 137.9 7.6 2.6e-27 95.8 0.2 2.9 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85826.1 - 8.7e-27 94.0 0.4 6.2e-17 61.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DUF3408 PF11888.8 EFA85826.1 - 0.03 14.5 4.0 12 6.0 3.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3408) EPO_TPO PF00758.18 EFA85826.1 - 0.034 14.2 0.9 0.034 14.2 0.9 2.1 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin Kinase-like PF14531.6 EFA85826.1 - 0.063 12.6 1.3 0.11 11.8 0.0 2.0 2 1 1 3 3 3 0 Kinase-like APH PF01636.23 EFA85826.1 - 0.19 11.6 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Androgen_recep PF02166.16 EFA85826.1 - 0.42 9.4 6.1 0.91 8.3 6.1 1.5 1 0 0 1 1 1 0 Androgen receptor LRR_8 PF13855.6 EFA85827.1 - 4.9e-05 23.0 0.6 4.9e-05 23.0 0.6 3.4 3 1 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 EFA85827.1 - 0.021 15.2 5.3 0.021 15.2 5.3 5.5 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) EGF_alliinase PF04863.13 EFA85827.1 - 0.028 14.8 1.8 0.089 13.2 1.8 1.8 1 0 0 1 1 1 0 Alliinase EGF-like domain EGF_2 PF07974.13 EFA85827.1 - 0.14 12.6 4.4 0.33 11.4 4.4 1.6 1 0 0 1 1 1 0 EGF-like domain LRR_9 PF14580.6 EFA85827.1 - 0.15 11.5 0.3 0.34 10.4 0.3 1.5 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 EFA85827.1 - 0.84 9.9 0.0 0.84 9.9 0.0 3.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EFA85827.1 - 1.4 9.8 5.1 1.2 10.0 0.7 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat TIG PF01833.24 EFA85827.1 - 5.7 7.1 16.4 0.081 13.0 4.4 3.9 3 1 1 4 4 4 0 IPT/TIG domain LSM PF01423.22 EFA85828.1 - 7.1e-09 35.2 1.8 6.7e-08 32.1 1.8 2.4 1 1 0 1 1 1 1 LSM domain Caskin-tail PF16632.5 EFA85828.1 - 0.056 13.9 0.1 0.056 13.9 0.1 3.2 4 1 0 4 4 4 0 C-terminal region of Caskin HEAT PF02985.22 EFA85829.1 - 1.6e-36 121.2 4.1 0.00011 22.1 0.0 9.4 9 0 0 9 9 9 6 HEAT repeat HEAT_2 PF13646.6 EFA85829.1 - 4e-21 75.2 0.0 0.00069 20.0 0.0 6.5 4 1 3 7 7 7 5 HEAT repeats Vac14_Fab1_bd PF12755.7 EFA85829.1 - 5.4e-13 49.4 0.6 0.00092 19.8 0.0 6.2 5 1 1 6 6 6 2 Vacuolar 14 Fab1-binding region DUF1242 PF06842.12 EFA85829.1 - 1.2e-12 47.4 0.9 2.5e-12 46.4 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Cnd1 PF12717.7 EFA85829.1 - 1.7e-10 41.2 11.6 0.12 12.5 0.0 5.5 4 2 1 5 5 5 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFA85829.1 - 2e-05 25.0 1.2 3.7 8.2 0.0 5.1 5 1 1 6 6 5 1 HEAT-like repeat Arm PF00514.23 EFA85829.1 - 0.0003 20.7 0.0 13 6.0 0.0 5.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HCO3_cotransp PF00955.21 EFA85829.1 - 0.0018 17.2 2.2 0.0028 16.6 2.2 1.2 1 0 0 1 1 1 1 HCO3- transporter family TAF6_C PF07571.13 EFA85829.1 - 0.0039 17.5 0.0 1.2 9.6 0.0 4.2 2 2 1 4 4 4 1 TAF6 C-terminal HEAT repeat domain ABC2_membrane_3 PF12698.7 EFA85829.1 - 0.0088 15.2 11.7 0.016 14.3 11.7 1.5 1 0 0 1 1 1 1 ABC-2 family transporter protein Cohesin_HEAT PF12765.7 EFA85829.1 - 0.029 14.7 4.4 11 6.4 0.0 4.5 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion Nipped-B_C PF12830.7 EFA85829.1 - 0.19 11.7 1.7 11 5.9 0.1 3.5 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus FAM60A PF15396.6 EFA85829.1 - 0.21 11.5 5.5 0.4 10.7 5.5 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CSG2 PF16965.5 EFA85829.1 - 0.24 10.3 5.1 0.53 9.2 5.1 1.6 1 0 0 1 1 1 0 Ceramide synthase regulator PNISR PF15996.5 EFA85829.1 - 0.32 11.2 6.3 0.6 10.4 6.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Zip PF02535.22 EFA85829.1 - 0.41 9.8 4.1 0.72 9.0 4.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SDA1 PF05285.12 EFA85829.1 - 0.52 9.7 11.3 0.9 8.9 11.3 1.3 1 0 0 1 1 1 0 SDA1 ALMT PF11744.8 EFA85829.1 - 2.2 7.0 9.1 3.6 6.3 9.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter EOS1 PF12326.8 EFA85829.1 - 2.2 8.2 4.9 4.9 7.0 4.9 1.6 1 0 0 1 1 1 0 N-glycosylation protein CPSF100_C PF13299.6 EFA85829.1 - 4.3 7.5 7.5 9.7 6.3 7.5 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1635 PF07795.11 EFA85829.1 - 4.9 7.0 7.7 9.3 6.0 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Cellulase PF00150.18 EFA85830.1 - 4.2e-31 108.4 0.0 7.8e-31 107.5 0.0 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 EFA85830.1 - 3.2e-18 66.0 0.8 5.8e-18 65.2 0.8 1.4 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_42 PF02449.15 EFA85830.1 - 0.00046 19.6 0.1 0.0027 17.1 0.0 2.0 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_1 PF00232.18 EFA85830.1 - 0.024 13.1 0.0 0.044 12.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Cuticle_2 PF08184.11 EFA85830.1 - 0.051 13.6 1.2 0.15 12.1 0.1 2.3 2 0 0 2 2 2 0 Cuticle protein 7 isoform family TPR_12 PF13424.6 EFA85831.1 - 1.5e-07 31.6 2.8 0.0054 17.0 0.6 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85831.1 - 2.4e-05 24.1 9.0 0.059 13.5 0.1 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA85831.1 - 0.0014 19.3 0.1 16 6.6 0.0 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF4601 PF15373.6 EFA85831.1 - 0.0074 15.3 0.2 0.13 11.2 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4601) TPR_1 PF00515.28 EFA85831.1 - 0.019 14.8 7.0 0.17 11.8 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 EFA85831.1 - 0.073 12.5 6.6 2.4 7.5 1.8 2.2 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 EFA85831.1 - 0.086 12.2 0.1 0.61 9.4 0.1 2.3 1 1 1 2 2 2 0 MalT-like TPR region TPR_16 PF13432.6 EFA85831.1 - 0.14 12.8 4.4 7.9 7.2 0.0 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 EFA85831.1 - 0.16 11.7 6.9 5.4 6.7 0.1 3.5 4 0 0 4 4 4 0 26S proteasome subunit RPN7 TPR_8 PF13181.6 EFA85831.1 - 0.29 11.5 6.3 15 6.1 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DOG1 PF14144.6 EFA85831.1 - 0.38 11.0 1.7 2.4 8.4 0.1 2.8 3 0 0 3 3 3 0 Seed dormancy control TPR_10 PF13374.6 EFA85831.1 - 4.9 7.2 7.0 17 5.5 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribosomal_L25p PF01386.19 EFA85832.1 - 1.8e-06 28.4 0.0 3.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L25p family GyrI-like PF06445.15 EFA85833.1 - 7.4e-24 84.8 0.1 8.3e-24 84.7 0.1 1.0 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 EFA85833.1 - 6.9e-10 39.3 0.1 9.8e-10 38.8 0.1 1.2 1 0 0 1 1 1 1 Integron-associated effector binding protein DUF5371 PF17341.2 EFA85833.1 - 0.15 12.3 0.3 0.57 10.4 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5371) SRF-TF PF00319.18 EFA85834.1 - 2.3e-21 75.0 0.1 3.6e-21 74.4 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIA PF03153.13 EFA85834.1 - 0.004 17.2 18.7 0.005 16.9 18.7 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Tmpp129 PF10272.9 EFA85834.1 - 0.061 12.6 0.1 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor STELLO PF03385.17 EFA85835.1 - 0.068 12.0 0.2 0.078 11.8 0.2 1.0 1 0 0 1 1 1 0 STELLO glycosyltransferases Glucokinase PF02685.16 EFA85837.1 - 8.1e-17 61.2 0.0 1.3e-16 60.5 0.0 1.4 1 1 0 1 1 1 1 Glucokinase ROK PF00480.20 EFA85837.1 - 0.0052 16.3 0.4 0.17 11.3 0.4 2.6 1 1 0 1 1 1 1 ROK family Beta-lactamase PF00144.24 EFA85838.1 - 1.8e-39 135.9 0.0 3e-39 135.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase DUF2039 PF10217.9 EFA85838.1 - 6.8e-25 87.2 11.4 2.6e-24 85.4 11.4 2.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Paired_CXXCH_1 PF09699.10 EFA85838.1 - 0.0097 15.6 0.7 0.031 14.0 0.7 1.9 1 0 0 1 1 1 1 Doubled CXXCH motif (Paired_CXXCH_1) Mpp10 PF04006.12 EFA85838.1 - 0.024 13.1 57.3 0.034 12.6 57.3 1.1 1 0 0 1 1 1 0 Mpp10 protein Cript PF10235.9 EFA85838.1 - 0.043 14.4 9.2 0.16 12.6 9.2 2.1 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT DUF3079 PF11278.8 EFA85838.1 - 0.15 11.9 1.2 29 4.6 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) zinc-ribbons_6 PF07191.12 EFA85838.1 - 0.42 10.6 10.1 0.85 9.6 10.1 1.5 1 0 0 1 1 1 0 zinc-ribbons TFIIF_alpha PF05793.12 EFA85838.1 - 6.5 5.2 62.0 11 4.5 62.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BppL_N PF18338.1 EFA85839.1 - 9 6.2 7.9 1.1 9.2 2.5 2.3 2 0 0 2 2 2 0 Lower baseplate protein N-terminal domain A_deamin PF02137.18 EFA85840.1 - 4.8e-69 233.3 0.3 2e-68 231.3 0.3 1.9 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain LSM PF01423.22 EFA85841.1 - 1.3e-18 66.5 0.0 1.5e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA85841.1 - 0.068 13.3 0.0 0.085 13.0 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain FKBP_C PF00254.28 EFA85842.1 - 1.2e-28 99.2 0.1 1.4e-28 99.0 0.1 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase GCS PF03074.16 EFA85843.1 - 3.7e-169 562.9 1.1 4.6e-169 562.5 1.1 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase WH1 PF00568.23 EFA85844.1 - 1.5e-24 86.0 0.1 2.6e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 EFA85844.1 - 3.8e-11 43.2 0.7 1.2e-10 41.6 0.0 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain WH2 PF02205.20 EFA85844.1 - 2.2e-06 27.3 0.5 4.5e-06 26.3 0.5 1.5 1 0 0 1 1 1 1 WH2 motif DCP1 PF06058.13 EFA85844.1 - 0.00041 20.3 0.2 0.00082 19.3 0.2 1.5 1 0 0 1 1 1 1 Dcp1-like decapping family LIM PF00412.22 EFA85845.1 - 3e-12 46.6 11.3 3.7e-12 46.3 7.9 2.0 2 0 0 2 2 2 1 LIM domain DZR PF12773.7 EFA85845.1 - 0.00023 21.1 5.3 0.032 14.3 0.1 2.7 1 1 1 2 2 2 2 Double zinc ribbon zf-FPG_IleRS PF06827.14 EFA85845.1 - 0.0077 16.1 6.3 0.5 10.3 0.2 3.4 3 0 0 3 3 3 1 Zinc finger found in FPG and IleRS zf-ISL3 PF14690.6 EFA85845.1 - 0.023 15.4 3.6 5 7.9 0.4 3.4 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 TcpF PF06340.11 EFA85845.1 - 0.027 13.3 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F DNA_ligase_ZBD PF03119.16 EFA85845.1 - 0.052 13.6 3.5 3.1 7.9 0.0 3.0 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C3HC4_5 PF17121.5 EFA85845.1 - 0.25 11.2 9.5 3.1 7.7 4.0 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Zn-ribbon_8 PF09723.10 EFA85845.1 - 0.58 10.3 10.3 5.5 7.2 0.0 3.5 3 0 0 3 3 3 0 Zinc ribbon domain YacG PF03884.14 EFA85845.1 - 0.68 9.7 11.4 1.7 8.4 0.1 3.5 3 1 0 3 3 3 0 DNA gyrase inhibitor YacG zinc-ribbons_6 PF07191.12 EFA85845.1 - 1.1 9.3 10.1 5.6 7.0 6.1 2.4 2 1 0 2 2 2 0 zinc-ribbons NOB1_Zn_bind PF08772.11 EFA85845.1 - 1.2 9.4 12.3 0.18 12.0 3.6 2.7 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like OrfB_Zn_ribbon PF07282.11 EFA85845.1 - 1.5 8.8 11.5 24 4.9 0.0 3.1 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-CCHC_5 PF14787.6 EFA85845.1 - 2.6 7.9 16.9 0.44 10.3 0.6 4.4 4 1 1 5 5 5 0 GAG-polyprotein viral zinc-finger Ribosomal_L37e PF01907.19 EFA85845.1 - 3 8.1 11.6 4.1 7.6 5.2 3.5 2 1 1 3 3 3 0 Ribosomal protein L37e Zn_Tnp_IS1595 PF12760.7 EFA85845.1 - 3.9 7.5 16.7 52 3.9 0.0 3.7 2 1 0 3 3 3 0 Transposase zinc-ribbon domain zinc_ribbon_9 PF14369.6 EFA85845.1 - 5.3 7.4 12.2 13 6.2 3.4 3.3 3 0 0 3 3 3 0 zinc-ribbon DUF3268 PF11672.8 EFA85845.1 - 5.8 7.3 8.2 0.45 10.9 2.5 2.0 2 1 0 2 2 2 0 zinc-finger-containing domain Phage_holin_2_1 PF04971.12 EFA85846.1 - 0.086 12.9 0.5 13 5.8 0.1 2.7 2 0 0 2 2 2 0 Bacteriophage P21 holin S EGF PF00008.27 EFA85846.1 - 0.2 12.0 10.9 0.48 10.8 10.9 1.7 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA85846.1 - 0.36 11.2 11.6 0.71 10.3 11.6 1.5 1 0 0 1 1 1 0 EGF-like domain TCR PF03638.15 EFA85847.1 - 6.4e-10 39.2 25.4 6.4e-10 39.2 25.4 2.3 2 0 0 2 2 2 1 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 EFA85847.1 - 0.14 12.3 21.4 0.024 14.8 16.5 2.3 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 ABC_tran PF00005.27 EFA85848.1 - 2.6e-50 170.5 0.1 2.2e-24 86.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 EFA85848.1 - 6.5e-50 169.5 32.8 2.1e-28 99.2 18.1 3.5 4 0 0 4 4 3 2 ABC-2 type transporter RsgA_GTPase PF03193.16 EFA85848.1 - 1.6e-08 34.6 0.1 0.0028 17.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFA85848.1 - 9.7e-08 31.7 0.3 0.002 17.8 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA85848.1 - 1.7e-06 28.5 0.0 0.07 13.5 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFA85848.1 - 2.4e-05 24.3 0.4 0.13 12.0 0.0 4.0 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFA85848.1 - 3.2e-05 24.0 0.0 0.16 11.9 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_22 PF13401.6 EFA85848.1 - 5.4e-05 23.5 0.2 0.59 10.4 0.1 2.8 2 0 0 2 2 2 2 AAA domain PDR_assoc PF08370.11 EFA85848.1 - 0.00023 20.9 0.8 0.00023 20.9 0.8 3.3 3 0 0 3 3 3 1 Plant PDR ABC transporter associated AAA_25 PF13481.6 EFA85848.1 - 0.00023 20.8 0.0 0.31 10.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EFA85848.1 - 0.00025 21.1 0.3 0.58 10.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFA85848.1 - 0.00099 19.5 0.1 2 8.8 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA PF00004.29 EFA85848.1 - 0.0012 19.3 0.2 0.36 11.3 0.0 2.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFA85848.1 - 0.0021 18.2 2.8 0.19 11.9 0.0 3.3 4 0 0 4 4 3 1 AAA domain NACHT PF05729.12 EFA85848.1 - 0.0046 16.9 0.7 0.96 9.3 0.0 2.4 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 EFA85848.1 - 0.0096 15.7 0.0 4.8 6.9 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein Trehalose_PPase PF02358.16 EFA85848.1 - 0.012 14.8 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Trehalose-phosphatase AAA_28 PF13521.6 EFA85848.1 - 0.017 15.4 0.3 4.2 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFA85848.1 - 0.017 15.7 4.9 1.5 9.3 0.0 3.5 5 0 0 5 5 2 0 AAA domain DUF815 PF05673.13 EFA85848.1 - 0.019 14.2 0.0 0.61 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 EFA85848.1 - 0.02 14.6 0.1 4.2 7.0 0.3 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFA85848.1 - 0.029 14.3 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PDR_CDR PF06422.12 EFA85848.1 - 0.036 14.0 5.8 1.6 8.7 0.8 3.4 3 0 0 3 3 2 0 CDR ABC transporter Zeta_toxin PF06414.12 EFA85848.1 - 0.08 12.2 0.2 6.6 6.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 EFA85848.1 - 0.084 13.4 10.4 0.77 10.2 0.1 3.7 4 1 0 4 4 3 0 AAA domain AAA_5 PF07728.14 EFA85848.1 - 0.23 11.4 1.8 8.8 6.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFA85848.1 - 0.42 9.9 1.5 19 4.6 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI polyprenyl_synt PF00348.17 EFA85849.1 - 1.5e-91 306.0 0.0 2.5e-91 305.3 0.0 1.4 1 0 0 1 1 1 1 Polyprenyl synthetase WD40 PF00400.32 EFA85849.1 - 7.6e-08 32.9 27.2 0.11 13.5 0.3 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85849.1 - 0.0097 16.2 1.5 29 5.1 0.0 4.5 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA85849.1 - 0.025 13.9 0.1 1.5 8.1 0.1 2.3 1 1 1 2 2 2 0 WD40-like domain Exonuc_VII_L PF02601.15 EFA85849.1 - 0.96 9.0 17.0 2.4 7.7 6.6 2.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit ING PF12998.7 EFA85849.1 - 3 8.5 18.1 0.15 12.7 8.4 3.0 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Pkinase PF00069.25 EFA85850.1 - 1.2e-68 231.3 0.0 2.4e-68 230.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85850.1 - 5.1e-52 176.7 0.0 9.4e-52 175.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA85850.1 - 8.6e-08 31.4 0.2 8.6e-08 31.4 0.2 3.5 4 1 0 4 4 4 1 Fungal protein kinase Kinase-like PF14531.6 EFA85850.1 - 0.0055 16.1 0.0 0.02 14.2 0.0 1.9 1 1 0 1 1 1 1 Kinase-like PBD PF00786.28 EFA85850.1 - 0.02 15.2 0.1 0.12 12.7 0.1 2.5 1 0 0 1 1 1 0 P21-Rho-binding domain SAM_KSR1 PF13543.6 EFA85850.1 - 0.028 14.6 3.9 0.083 13.0 3.9 1.8 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 SH3_1 PF00018.28 EFA85851.1 - 3.2e-17 61.9 0.3 5.9e-17 61.0 0.3 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFA85851.1 - 8.9e-16 57.5 0.6 1.5e-15 56.8 0.6 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFA85851.1 - 2.3e-13 49.6 0.0 4.5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 EFA85851.1 - 4.8e-13 49.2 0.5 4.8e-13 49.2 0.5 3.6 2 1 1 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DUF885 PF05960.11 EFA85851.1 - 0.028 14.1 3.2 0.047 13.3 3.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) TEX12 PF15219.6 EFA85851.1 - 0.036 14.4 1.1 2.2 8.6 0.0 3.1 2 1 0 2 2 2 0 Testis-expressed 12 MscS_porin PF12795.7 EFA85851.1 - 0.093 12.3 10.9 0.12 11.9 4.3 2.5 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Phage_GPO PF05929.11 EFA85851.1 - 2.2 7.8 11.7 0.98 9.0 4.2 2.3 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase SHE3 PF17078.5 EFA85851.1 - 2.5 7.7 22.3 1.8 8.2 16.9 2.3 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DOT1 PF08123.13 EFA85852.1 - 2e-05 24.2 1.4 6.4e-05 22.6 1.4 1.8 1 1 0 1 1 1 1 Histone methylation protein DOT1 CheR PF01739.18 EFA85852.1 - 0.0047 16.4 0.3 0.0083 15.6 0.3 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_11 PF08241.12 EFA85852.1 - 0.021 15.5 0.2 0.27 11.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DUF2095 PF09868.9 EFA85852.1 - 0.041 13.9 0.7 0.088 12.8 0.7 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) Pirin_C PF05726.13 EFA85853.1 - 1.1e-27 96.4 0.0 2.4e-26 92.1 0.0 2.1 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Pirin PF02678.16 EFA85853.1 - 1.5e-23 82.9 0.0 2.5e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Pirin Cupin_3 PF05899.12 EFA85853.1 - 0.081 12.6 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF861) DUF1180 PF06679.12 EFA85854.1 - 0.015 15.7 0.1 0.64 10.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Vpu PF00558.19 EFA85854.1 - 0.03 14.1 0.3 0.03 14.1 0.3 2.0 2 0 0 2 2 2 0 Vpu protein Epiglycanin_C PF14654.6 EFA85854.1 - 0.092 12.8 0.2 0.47 10.6 0.0 2.2 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region FAM176 PF14851.6 EFA85854.1 - 0.12 12.0 3.4 0.83 9.3 0.0 2.4 2 0 0 2 2 2 0 FAM176 family Consortin_C PF15281.6 EFA85854.1 - 0.19 11.7 1.5 0.84 9.6 0.0 2.5 2 0 0 2 2 2 0 Consortin C-terminus EphA2_TM PF14575.6 EFA85854.1 - 0.32 11.9 3.0 0.33 11.9 0.0 2.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TFIIF_alpha PF05793.12 EFA85854.1 - 0.53 8.8 7.1 0.74 8.3 7.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SUIM_assoc PF16619.5 EFA85855.1 - 2.8e-07 30.5 0.3 0.0015 18.6 0.0 2.5 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Erf4 PF10256.9 EFA85855.1 - 0.05 13.7 0.5 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family DUF3327 PF11806.8 EFA85855.1 - 0.14 12.9 3.4 0.2 12.4 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3327) 5TM-5TMR_LYT PF07694.12 EFA85855.1 - 0.14 11.6 3.9 0.18 11.3 3.9 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT TFIIA PF03153.13 EFA85855.1 - 4 7.3 20.9 4.9 7.0 20.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EFA85855.1 - 4.2 6.9 20.1 5.7 6.5 20.1 1.2 1 0 0 1 1 1 0 Spt20 family RsfS PF02410.15 EFA85856.1 - 2.9e-19 69.3 0.2 2.9e-19 69.3 0.2 2.4 2 1 0 2 2 2 1 Ribosomal silencing factor during starvation TFIIA PF03153.13 EFA85856.1 - 1.2 9.0 46.6 0.76 9.7 33.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RlaP PF10127.9 EFA85857.1 - 8.6e-22 77.9 2.6 2.1e-14 53.8 1.4 2.7 2 2 0 2 2 2 2 RNA repair pathway DNA polymerase beta family HSP70 PF00012.20 EFA85858.1 - 1.8e-251 835.6 5.9 2.2e-251 835.3 5.9 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFA85858.1 - 1.4e-14 53.7 2.1 6.9e-12 44.8 0.1 2.8 3 1 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 EFA85858.1 - 1.3e-05 25.5 4.1 2.9 8.4 0.0 4.1 3 2 0 3 3 3 3 Cell division protein FtsA FGGY_C PF02782.16 EFA85858.1 - 0.0021 17.8 0.0 0.0098 15.6 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain GFRP PF06399.13 EFA85858.1 - 0.16 11.8 0.0 0.5 10.3 0.0 1.8 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) MCD_N PF17408.2 EFA85859.1 - 0.4 10.9 2.2 0.62 10.2 0.2 2.1 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain DUF812 PF05667.11 EFA85859.1 - 0.97 8.2 11.5 0.033 13.1 4.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF812) tRNA-synt_2b PF00587.25 EFA85860.1 - 5e-37 127.6 0.0 8.4e-37 126.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFA85860.1 - 6.3e-20 71.1 0.0 1.3e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EFA85860.1 - 1.5e-07 31.3 1.0 1.2e-06 28.4 0.0 2.8 4 0 0 4 4 4 1 TGS domain Ribonuclease_3 PF00636.26 EFA85862.1 - 2.1e-37 128.0 0.0 4e-17 62.8 0.0 3.8 2 1 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFA85862.1 - 1.4e-36 125.5 0.0 1.4e-18 67.3 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EFA85862.1 - 2.2e-06 28.3 0.0 6e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif VIT PF08487.10 EFA85862.1 - 0.053 13.7 0.2 0.14 12.4 0.2 1.7 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain NOA36 PF06524.12 EFA85862.1 - 1.6 8.0 24.2 0.18 11.1 19.0 2.0 2 0 0 2 2 2 0 NOA36 protein DivIC PF04977.15 EFA85862.1 - 1.9 8.3 5.9 0.81 9.5 3.0 1.8 2 0 0 2 2 2 0 Septum formation initiator Fer2 PF00111.27 EFA85863.1 - 1.3e-13 50.7 0.3 2e-13 50.1 0.3 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain LURAP PF14854.6 EFA85863.1 - 3.1 7.8 6.5 4.8 7.2 6.5 1.3 1 0 0 1 1 1 0 Leucine rich adaptor protein DnaJ PF00226.31 EFA85864.1 - 8.5e-27 93.1 4.7 2e-26 91.9 4.7 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.6 EFA85864.1 - 1.2e-15 57.5 11.5 1.3e-11 44.3 9.1 3.9 1 1 2 3 3 3 2 X-domain of DnaJ-containing Armet PF10208.9 EFA85864.1 - 3.4e-05 23.8 0.2 0.0002 21.3 0.1 2.2 2 0 0 2 2 2 1 Degradation arginine-rich protein for mis-folding DUF16 PF01519.16 EFA85864.1 - 0.025 15.0 1.5 0.054 14.0 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF1643 PF07799.12 EFA85864.1 - 0.037 14.2 0.0 0.29 11.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1643) DUF3439 PF11921.8 EFA85864.1 - 4.9 7.1 10.2 8.5 6.4 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 EFA85865.1 - 4.8e-54 183.5 0.0 7.6e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85865.1 - 6.2e-53 179.7 0.0 8.9e-53 179.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA85865.1 - 2.1e-06 26.8 0.0 3.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFA85865.1 - 0.0015 18.5 0.1 0.08 12.9 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family NUDIX PF00293.28 EFA85867.1 - 8.2e-17 61.5 0.0 1.1e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF2255 PF10012.9 EFA85867.1 - 0.12 12.5 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) ATG_C PF09333.11 EFA85868.1 - 3.4e-20 72.2 0.0 1.2e-19 70.4 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 EFA85868.1 - 9.7e-10 38.6 2.3 1e-08 35.3 0.1 3.1 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 EFA85868.1 - 9.9e-05 22.2 3.7 0.0012 18.7 0.1 3.4 3 0 0 3 3 3 1 Vacuolar-sorting-associated 13 protein C-terminal Anophelin PF10731.9 EFA85869.1 - 0.023 14.5 0.0 0.078 12.8 0.0 1.8 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito IF-2B PF01008.17 EFA85869.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family DUF1180 PF06679.12 EFA85869.1 - 0.25 11.7 1.2 0.44 10.9 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) TMEM154 PF15102.6 EFA85869.1 - 2.4 8.0 6.5 4.8 7.1 6.5 1.4 1 0 0 1 1 1 0 TMEM154 protein family DIL PF01843.19 EFA85870.1 - 2.7e-20 72.6 0.6 2.7e-20 72.6 0.6 2.8 2 1 0 2 2 2 1 DIL domain CENP-F_leu_zip PF10473.9 EFA85870.1 - 7.1e-05 22.9 164.1 0.00019 21.5 31.7 9.2 2 1 6 8 8 8 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PspA_IM30 PF04012.12 EFA85870.1 - 0.0021 17.7 15.6 0.0021 17.7 15.6 7.9 2 1 3 6 6 6 2 PspA/IM30 family SYCE1 PF15233.6 EFA85870.1 - 0.0027 17.8 21.5 0.0027 17.8 21.5 7.2 2 1 5 8 8 8 1 Synaptonemal complex central element protein 1 MAD PF05557.13 EFA85870.1 - 0.005 15.3 151.9 0.011 14.1 38.1 5.3 1 1 3 5 5 5 3 Mitotic checkpoint protein Spc7 PF08317.11 EFA85870.1 - 0.009 14.9 160.5 0.0065 15.4 24.3 8.2 2 1 5 8 8 8 6 Spc7 kinetochore protein CALCOCO1 PF07888.11 EFA85870.1 - 0.028 13.3 144.2 0.04 12.8 41.9 4.6 1 1 3 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like Taxilin PF09728.9 EFA85870.1 - 0.051 12.7 153.8 0.18 11.0 9.6 5.9 2 1 2 5 5 5 0 Myosin-like coiled-coil protein Pox_A_type_inc PF04508.12 EFA85870.1 - 0.44 10.5 30.8 1.5 8.8 1.5 7.4 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat TPR_MLP1_2 PF07926.12 EFA85870.1 - 0.79 9.8 167.8 0.058 13.5 33.0 9.7 2 1 7 9 9 9 0 TPR/MLP1/MLP2-like protein Gelsolin PF00626.22 EFA85871.1 - 4.1e-18 65.1 10.1 2.6e-05 24.0 0.0 6.9 8 0 0 8 8 8 4 Gelsolin repeat WD40 PF00400.32 EFA85872.1 - 1.6e-07 31.9 2.6 0.4 11.6 0.1 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85872.1 - 0.0031 17.8 0.0 10 6.5 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 EFA85872.1 - 0.0036 16.4 0.0 0.2 10.6 0.0 2.1 2 0 0 2 2 2 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 EFA85872.1 - 0.038 12.5 0.0 0.078 11.5 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain RasGEF PF00617.19 EFA85873.1 - 2.7e-63 213.4 0.7 6.1e-63 212.2 0.7 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFA85873.1 - 8.9e-26 90.2 0.3 8.9e-26 90.2 0.3 4.7 5 0 0 5 5 5 1 RasGEF N-terminal motif Nbl1_Borealin_N PF10444.9 EFA85873.1 - 1.1e-25 89.0 1.3 3.1e-25 87.6 1.3 1.8 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal UT PF03253.14 EFA85875.1 - 1.7e-09 37.2 12.8 2.3e-08 33.6 12.8 2.1 1 1 0 1 1 1 1 Urea transporter FNIP PF05725.12 EFA85876.1 - 1.3e-17 63.7 16.8 1.8e-09 37.6 1.1 3.5 2 1 1 3 3 3 3 FNIP Repeat Nkap_C PF06047.11 EFA85877.1 - 2.4e-46 156.0 3.4 2.4e-46 156.0 3.4 2.2 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain RCC1 PF00415.18 EFA85878.1 - 1.1e-30 106.0 1.8 9.3e-13 48.6 0.0 6.7 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA85878.1 - 5.2e-22 77.1 8.5 4.4e-10 39.1 0.3 6.2 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Myc_N PF01056.18 EFA85878.1 - 0.003 17.5 0.3 0.0059 16.5 0.3 1.6 1 0 0 1 1 1 1 Myc amino-terminal region Cwf_Cwc_15 PF04889.12 EFA85878.1 - 0.72 9.5 5.2 1.1 8.9 5.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SPC25 PF06703.11 EFA85879.1 - 2.8e-35 121.5 1.1 3.8e-35 121.1 1.1 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) SCIMP PF15050.6 EFA85879.1 - 0.044 14.2 4.6 0.15 12.5 1.6 2.3 2 1 0 2 2 2 0 SCIMP protein SKIP_SNW PF02731.15 EFA85880.1 - 7.6e-70 233.7 3.5 7.6e-70 233.7 3.5 2.6 2 1 0 2 2 2 1 SKIP/SNW domain EF-hand_1 PF00036.32 EFA85881.1 - 6.7e-25 84.7 7.9 6.6e-08 31.6 0.2 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EFA85881.1 - 2e-22 79.4 2.3 6.2e-14 52.2 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA85881.1 - 3.8e-21 73.2 8.4 1e-07 31.3 0.3 5.3 4 2 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EFA85881.1 - 5.8e-13 48.5 10.2 8.7e-09 35.1 0.4 4.7 2 2 3 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA85881.1 - 2.7e-10 39.3 13.3 9.2e-06 24.9 0.7 5.0 5 0 0 5 5 5 3 EF hand EF-hand_9 PF14658.6 EFA85881.1 - 1.1e-09 38.4 0.2 3.4e-06 27.3 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFA85881.1 - 0.0014 18.5 0.7 0.065 13.2 0.1 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand T3SS_HrpK1 PF16937.5 EFA85881.1 - 0.004 16.9 0.7 1.5 8.5 0.1 2.1 1 1 1 2 2 2 2 Type III secretion system translocator protein, HrpF Caleosin PF05042.13 EFA85881.1 - 0.0062 16.5 0.5 0.056 13.4 0.2 2.5 1 1 1 2 2 2 1 Caleosin related protein PBS_linker_poly PF00427.21 EFA85881.1 - 0.01 15.9 0.3 0.027 14.5 0.1 1.8 3 0 0 3 3 3 0 Phycobilisome Linker polypeptide EF-hand_14 PF17959.1 EFA85881.1 - 0.021 15.2 3.2 1.9 8.9 3.2 2.8 1 1 0 1 1 1 0 EF-hand domain DUF327 PF03885.13 EFA85881.1 - 0.028 14.4 3.7 0.56 10.2 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF327) RTX_C PF08339.10 EFA85881.1 - 0.036 14.1 3.1 0.51 10.4 0.4 2.2 1 1 1 2 2 2 0 RTX C-terminal domain CtsR_C PF17727.1 EFA85881.1 - 0.071 13.2 0.1 13 6.0 0.0 2.5 2 0 0 2 2 2 0 CtsR C-terminal dimerization domain DUF1456 PF07308.13 EFA85881.1 - 0.092 13.1 0.2 3.5 8.0 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) Dak1 PF02733.17 EFA85882.1 - 1.2e-110 369.3 0.3 1.6e-110 368.9 0.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EFA85882.1 - 1.3e-46 158.7 0.0 2e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 DAK2 domain C2 PF00168.30 EFA85883.1 - 3.6e-18 65.7 0.1 1.7e-17 63.6 0.0 2.2 2 0 0 2 2 2 1 C2 domain GRAM PF02893.20 EFA85883.1 - 3.6e-12 46.2 2.7 1.8e-11 43.9 2.7 2.3 1 0 0 1 1 1 1 GRAM domain Membr_traf_MHD PF10540.9 EFA85883.1 - 6.4e-08 32.9 1.5 7.6e-05 22.9 0.0 3.5 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain DUF810 PF05664.11 EFA85883.1 - 4.2e-07 28.9 2.0 4.4e-07 28.8 0.2 1.8 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) E2F_CC-MB PF16421.5 EFA85884.1 - 2.5e-29 101.5 0.4 2.5e-29 101.5 0.4 4.4 5 0 0 5 5 5 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 EFA85884.1 - 1.1e-19 70.3 1.4 4.1e-19 68.4 0.1 2.7 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain BORCS6 PF10157.9 EFA85884.1 - 2.6e-09 37.5 4.3 2.6e-09 37.5 4.3 4.4 4 1 0 5 5 5 1 BLOC-1-related complex sub-unit 6 TMF_DNA_bd PF12329.8 EFA85884.1 - 0.013 15.4 2.8 0.013 15.4 2.8 6.9 7 0 0 7 7 7 0 TATA element modulatory factor 1 DNA binding DUF3439 PF11921.8 EFA85884.1 - 0.078 13.0 26.2 0.54 10.2 2.2 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF3439) FMO-like PF00743.19 EFA85885.1 - 9.5e-58 195.9 0.8 1.2e-57 195.6 0.8 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFA85885.1 - 1.9e-13 50.4 0.1 3.7e-11 42.9 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA85885.1 - 3.9e-08 32.9 0.0 1.6e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFA85885.1 - 8.4e-06 25.1 0.8 2.4e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFA85885.1 - 3.7e-05 23.5 0.0 0.36 10.3 0.0 2.9 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA85885.1 - 0.0004 20.6 0.0 0.0013 19.0 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFA85885.1 - 0.0016 18.4 0.0 0.01 15.8 0.0 2.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EFA85885.1 - 0.0022 18.5 0.1 0.49 11.0 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFA85885.1 - 0.011 14.5 0.0 0.02 13.6 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 EFA85885.1 - 0.15 11.2 0.7 3.7 6.7 0.1 2.2 2 0 0 2 2 2 0 Thi4 family ADK PF00406.22 EFA85886.1 - 1.4e-58 197.3 0.0 1.8e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFA85886.1 - 3.9e-23 82.4 0.1 9.5e-23 81.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EFA85886.1 - 5.9e-17 61.3 0.0 1.1e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid RuvB_N PF05496.12 EFA85886.1 - 0.0034 17.1 0.0 0.019 14.7 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Hydin_ADK PF17213.3 EFA85886.1 - 0.005 17.1 0.5 2.9 8.1 0.1 2.4 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 EFA85886.1 - 0.0053 16.9 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain Aminotran_5 PF00266.19 EFA85887.1 - 8.2e-50 169.8 0.0 9.3e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V HEAT_EZ PF13513.6 EFA85888.1 - 6e-38 128.8 0.0 4.2e-16 59.1 0.1 9.0 8 1 2 10 10 10 4 HEAT-like repeat HEAT PF02985.22 EFA85888.1 - 1.9e-28 96.1 7.4 0.0013 18.8 0.1 10.7 10 1 1 11 11 10 6 HEAT repeat HEAT_2 PF13646.6 EFA85888.1 - 2.7e-21 75.7 0.0 0.0081 16.5 0.0 7.9 4 3 4 8 8 8 4 HEAT repeats Cnd1 PF12717.7 EFA85888.1 - 6.1e-13 49.1 0.9 7.9e-05 22.8 0.0 5.2 4 2 0 4 4 4 4 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 EFA85888.1 - 3.2e-12 46.2 0.6 2.4e-11 43.4 0.0 3.0 3 0 0 3 3 2 1 Importin-beta N-terminal domain Arm PF00514.23 EFA85888.1 - 2.6e-11 43.1 0.2 0.028 14.5 0.0 5.6 5 0 0 5 5 4 3 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 EFA85888.1 - 4.1e-09 36.9 0.1 1.3 9.7 0.0 7.2 4 2 4 9 9 9 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EFA85888.1 - 2e-07 30.0 3.1 0.00081 18.1 0.4 3.8 2 2 0 2 2 2 2 Adaptin N terminal region DUF3385 PF11865.8 EFA85888.1 - 0.00012 22.0 1.2 0.059 13.3 0.0 4.9 4 2 1 5 5 5 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 EFA85888.1 - 0.00014 21.5 0.0 20 4.7 0.0 5.5 4 2 0 4 4 4 0 CLASP N terminal DUF3437 PF11919.8 EFA85888.1 - 0.00015 21.6 2.5 0.062 13.2 0.0 5.4 5 0 0 5 5 5 1 Domain of unknown function (DUF3437) UME PF08064.13 EFA85888.1 - 0.005 16.7 0.1 38 4.3 0.0 4.4 4 1 0 4 4 4 0 UME (NUC010) domain HEAT_PBS PF03130.16 EFA85888.1 - 0.012 16.2 0.2 1.2 10.0 0.1 4.0 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat NUC130_3NT PF08158.12 EFA85888.1 - 0.035 14.4 0.1 16 5.9 0.0 2.9 2 0 0 2 2 2 0 NUC130/3NT domain DUF4042 PF13251.6 EFA85888.1 - 0.14 11.8 0.1 2.7 7.7 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4042) DUF2462 PF09495.10 EFA85889.1 - 1.5e-06 28.8 17.3 1.5e-06 28.8 17.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2462) Secretin_N_2 PF07655.13 EFA85889.1 - 0.12 13.0 5.0 0.14 12.7 5.0 1.1 1 0 0 1 1 1 0 Secretin N-terminal domain PQ-loop PF04193.14 EFA85890.1 - 3.6e-25 87.5 7.4 2.9e-12 46.2 0.5 2.7 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EFA85890.1 - 0.021 14.8 1.3 0.021 14.8 1.3 2.6 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange YchF-GTPase_C PF06071.13 EFA85891.1 - 1e-40 137.8 1.0 1.8e-40 137.0 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFA85891.1 - 1.1e-20 73.8 0.0 5.6e-20 71.5 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA85891.1 - 1.2e-06 28.1 0.0 2.4e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 EFA85891.1 - 0.046 13.9 0.1 5.3 7.3 0.0 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 EFA85891.1 - 0.068 12.1 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB WD40 PF00400.32 EFA85892.1 - 0.099 13.5 3.0 0.62 11.0 0.1 3.5 4 0 0 4 4 4 0 WD domain, G-beta repeat MR_MLE_C PF13378.6 EFA85893.1 - 3.2e-19 69.4 0.0 2.3e-17 63.3 0.0 2.4 1 1 1 2 2 2 2 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFA85893.1 - 0.00029 21.0 0.0 0.00044 20.5 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain alpha-hel2 PF14456.6 EFA85893.1 - 0.083 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Alpha-helical domain 2 TPR_1 PF00515.28 EFA85894.1 - 1.8e-08 33.8 2.2 1.9e-06 27.5 0.6 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA85894.1 - 1.1e-07 31.4 2.5 6.7e-06 25.8 0.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA85894.1 - 3.9e-05 23.5 1.8 0.00039 20.4 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA85894.1 - 5.6e-05 23.3 0.1 0.00011 22.3 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFA85894.1 - 7.8e-05 23.1 0.4 0.0017 18.8 0.1 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA85894.1 - 0.00012 21.8 2.2 0.00015 21.5 0.5 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA85894.1 - 0.00019 21.7 0.4 0.00038 20.7 0.2 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA85894.1 - 0.00044 19.9 0.1 0.00083 19.0 0.1 1.5 1 0 0 1 1 1 1 TPR repeat TPR_17 PF13431.6 EFA85894.1 - 0.0008 19.6 0.1 0.049 14.0 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA85894.1 - 0.0014 19.3 0.0 0.0023 18.5 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA85894.1 - 0.0022 18.5 1.1 0.01 16.4 0.2 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA85894.1 - 0.0024 18.5 0.0 0.0043 17.8 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat MRNIP PF15749.5 EFA85894.1 - 1.7 9.4 6.8 0.15 12.8 0.7 2.3 4 0 0 4 4 3 0 MRN-interacting protein tRNA_edit PF04073.15 EFA85895.1 - 1.2e-06 28.6 0.0 6.1e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain Mog1 PF04603.12 EFA85895.1 - 0.085 13.2 1.9 0.65 10.4 0.1 2.4 2 1 0 2 2 2 0 Ran-interacting Mog1 protein FAD_syn PF06574.12 EFA85895.1 - 0.12 12.2 0.1 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 FAD synthetase Bact_lectin PF18483.1 EFA85896.1 - 9.8e-27 94.2 0.0 1.8e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EFA85896.1 - 2.3e-20 73.2 0.0 4.4e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Legume lectin domain Rad4 PF03835.15 EFA85896.1 - 2.8e-13 49.8 1.9 4.9e-13 49.0 1.9 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Lectin_leg-like PF03388.13 EFA85896.1 - 2.2e-10 40.3 0.1 3.6e-10 39.6 0.1 1.2 1 0 0 1 1 1 1 Legume-like lectin family Transglut_core PF01841.19 EFA85896.1 - 7.4e-10 39.3 0.3 7.4e-10 39.3 0.3 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily PAW PF04721.17 EFA85896.1 - 0.013 15.3 0.4 0.16 11.7 0.0 2.2 2 0 0 2 2 2 0 PNGase C-terminal domain, mannose-binding module PAW Arf PF00025.21 EFA85897.1 - 2.1e-62 209.7 0.6 2.5e-62 209.4 0.6 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA85897.1 - 6.1e-13 49.1 0.0 8.6e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA85897.1 - 3.4e-12 46.3 0.0 4e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFA85897.1 - 1.9e-10 40.5 0.1 2.4e-10 40.1 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFA85897.1 - 3.9e-06 26.3 1.3 0.00065 19.0 0.6 2.7 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFA85897.1 - 5.1e-05 23.3 0.1 6.9e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFA85897.1 - 7.7e-05 22.2 0.1 9.6e-05 21.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EFA85897.1 - 0.024 14.9 0.1 0.04 14.2 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFA85897.1 - 0.028 14.5 0.1 0.054 13.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFA85897.1 - 0.047 13.3 0.1 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_26 PF13500.6 EFA85897.1 - 0.074 12.9 0.1 0.12 12.2 0.1 1.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA85897.1 - 0.085 13.4 0.1 0.13 12.8 0.1 1.4 1 1 0 1 1 1 0 ABC transporter E1-E2_ATPase PF00122.20 EFA85898.1 - 2.6e-32 111.8 0.2 7e-32 110.4 0.2 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFA85898.1 - 2.1e-15 57.6 0.0 4.8e-11 43.3 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA85898.1 - 0.14 12.3 0.2 0.55 10.3 0.0 2.1 2 0 0 2 2 2 0 Cation transport ATPase (P-type) Ninjurin PF04923.12 EFA85898.1 - 0.25 11.3 2.9 0.3 11.0 0.2 2.5 3 0 0 3 3 3 0 Ninjurin YhhN PF07947.14 EFA85899.1 - 4.9e-07 29.5 2.6 6.7e-07 29.1 2.6 1.1 1 0 0 1 1 1 1 YhhN family SUIM_assoc PF16619.5 EFA85899.1 - 2.7 8.1 17.5 0.43 10.7 6.0 2.8 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt5_N PF11942.8 EFA85899.1 - 6.3 7.9 14.6 3.3 8.8 6.4 2.8 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal ParA PF10609.9 EFA85900.1 - 2.6e-53 181.0 1.3 1.5e-29 103.2 0.0 2.3 1 1 1 2 2 2 2 NUBPL iron-transfer P-loop NTPase PseudoU_synth_2 PF00849.22 EFA85900.1 - 2.9e-23 82.7 0.0 3.4e-22 79.2 0.0 2.7 3 1 0 3 3 3 1 RNA pseudouridylate synthase CbiA PF01656.23 EFA85900.1 - 2.5e-10 40.5 0.0 4e-09 36.6 0.0 2.7 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFA85900.1 - 1.1e-05 25.4 0.0 2.8e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFA85900.1 - 0.0011 18.2 1.1 0.055 12.6 0.5 2.4 2 0 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EFA85900.1 - 0.0022 17.3 0.0 0.0042 16.4 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 EFA85900.1 - 0.016 14.7 0.0 2 7.8 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 EFA85900.1 - 0.059 13.0 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 AAA domain IMUP PF15761.5 EFA85900.1 - 0.1 13.3 0.2 0.1 13.3 0.2 2.9 4 0 0 4 4 2 0 Immortalisation up-regulated protein Zn_Tnp_IS1595 PF12760.7 EFA85900.1 - 0.32 11.0 2.6 5.1 7.2 0.2 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain TFIIS_C PF01096.18 EFA85900.1 - 0.56 10.1 2.8 20 5.1 0.1 2.6 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Hep_59 PF07052.11 EFA85900.1 - 2.3 9.0 6.5 1 10.1 0.5 2.7 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 DUF4834 PF16118.5 EFA85900.1 - 8.6 7.4 6.1 16 6.5 0.4 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 EFA85901.1 - 9.3e-05 22.9 0.1 0.06 13.9 0.0 4.2 4 1 0 4 4 4 1 Ankyrin repeats (3 copies) DUF3447 PF11929.8 EFA85901.1 - 0.00017 21.5 1.6 0.0044 16.9 0.0 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3447) FNIP PF05725.12 EFA85902.1 - 2.3e-32 110.9 23.9 2.4e-12 46.8 0.0 7.4 7 1 0 7 7 7 5 FNIP Repeat F-box_5 PF18511.1 EFA85902.1 - 0.0018 17.8 2.9 0.09 12.4 0.2 2.7 2 0 0 2 2 2 2 F-box YoeB_toxin PF06769.14 EFA85902.1 - 0.18 11.8 4.1 1.4 9.0 0.2 2.9 3 0 0 3 3 3 0 YoeB-like toxin of bacterial type II toxin-antitoxin system LRR_4 PF12799.7 EFA85902.1 - 0.73 10.3 6.4 19 5.9 0.9 5.3 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA85902.1 - 4.6 8.2 7.3 48 5.1 0.2 5.3 4 1 0 4 4 4 0 Leucine Rich Repeat Ras PF00071.22 EFA85903.1 - 8.4e-51 171.8 0.0 1.2e-50 171.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA85903.1 - 1e-21 77.3 0.2 6.5e-21 74.8 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA85903.1 - 2.7e-07 30.2 0.2 7.2e-07 28.8 0.0 1.8 2 1 0 2 2 2 1 ADP-ribosylation factor family KapB PF08810.10 EFA85903.1 - 0.097 12.9 0.2 0.21 11.8 0.2 1.5 2 0 0 2 2 2 0 Kinase associated protein B COX6B PF02297.17 EFA85904.1 - 2.3e-18 66.2 4.7 2.3e-18 66.2 4.7 1.5 2 0 0 2 2 2 1 Cytochrome oxidase c subunit VIb Dfp1_Him1_M PF08630.10 EFA85904.1 - 0.013 15.7 0.3 0.015 15.5 0.3 1.1 1 0 0 1 1 1 0 Dfp1/Him1, central region CHCH PF06747.13 EFA85904.1 - 0.073 13.2 4.1 0.19 11.9 3.5 2.1 1 1 0 1 1 1 0 CHCH domain SNF2_N PF00176.23 EFA85905.1 - 4.1e-67 226.4 0.2 8.4e-67 225.4 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA85905.1 - 3.1e-16 59.7 0.0 1.9e-15 57.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EFA85905.1 - 8.5e-16 57.8 1.3 7.2e-15 54.8 0.3 2.8 2 0 0 2 2 2 1 Bromodomain HSA PF07529.13 EFA85905.1 - 5.4e-06 26.6 7.3 5.4e-06 26.6 7.3 3.7 3 0 0 3 3 3 1 HSA SnAC PF14619.6 EFA85905.1 - 6.6e-05 23.4 1.6 6.6e-05 23.4 1.6 4.1 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex zf-HIT PF04438.16 EFA85906.1 - 0.00011 22.0 4.5 0.00014 21.6 4.5 1.2 1 0 0 1 1 1 1 HIT zinc finger CDC45 PF02724.14 EFA85906.1 - 0.51 8.6 23.4 0.63 8.3 23.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EFA85906.1 - 1.8 7.9 32.0 2.4 7.5 32.0 1.2 1 0 0 1 1 1 0 SDA1 SPOUT_MTase PF02590.17 EFA85907.1 - 0.076 13.0 1.5 5.2 7.0 0.2 2.4 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase SPX PF03105.19 EFA85907.1 - 0.36 10.7 6.7 0.38 10.6 6.7 1.1 1 0 0 1 1 1 0 SPX domain Mito_fiss_reg PF05308.11 EFA85907.1 - 0.76 9.8 11.3 0.27 11.3 3.4 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator Mlf1IP PF10248.9 EFA85907.1 - 0.8 9.7 6.4 1.3 9.0 5.5 1.7 1 1 1 2 2 2 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein Pox_D2 PF04701.13 EFA85908.1 - 0.03 14.5 3.2 4.9 7.3 0.4 2.6 2 0 0 2 2 2 0 Pox virus D2 protein NDT80_PhoG PF05224.12 EFA85908.1 - 0.034 14.3 0.6 0.2 11.8 0.0 2.1 2 0 0 2 2 2 0 NDT80 / PhoG like DNA-binding family Interferon PF00143.19 EFA85908.1 - 0.11 12.6 0.8 4.8 7.3 0.4 2.8 2 1 1 3 3 3 0 Interferon alpha/beta domain HTH_51 PF18558.1 EFA85908.1 - 0.13 12.2 0.0 4.4 7.2 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain H_lectin PF09458.10 EFA85909.1 - 4e-22 78.2 0.0 1.2e-21 76.7 0.0 1.9 1 0 0 1 1 1 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA85909.1 - 3.6e-18 65.9 2.1 3.3e-14 53.1 0.1 2.3 2 0 0 2 2 2 2 F5/8 type C domain Glyco_transf_54 PF04666.13 EFA85909.1 - 0.032 13.1 0.0 0.046 12.6 0.0 1.2 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region H_lectin PF09458.10 EFA85910.1 - 1.4e-23 82.8 0.1 4.4e-23 81.2 0.1 1.9 1 0 0 1 1 1 1 H-type lectin domain F5_F8_type_C PF00754.25 EFA85910.1 - 1.1e-22 80.4 3.4 1.6e-22 79.9 3.4 1.2 1 0 0 1 1 1 1 F5/8 type C domain Complex1_LYR PF05347.15 EFA85911.1 - 1.2e-07 31.7 1.0 4.9e-07 29.7 1.0 2.0 1 1 0 1 1 1 1 Complex 1 protein (LYR family) OmdA PF13376.6 EFA85912.1 - 7.4e-10 38.7 1.4 2e-09 37.3 0.3 2.4 2 0 0 2 2 2 1 Bacteriocin-protection, YdeI or OmpD-Associated Ribosomal_60s PF00428.19 EFA85912.1 - 0.0055 17.3 2.1 1.5 9.5 1.2 2.5 2 0 0 2 2 2 2 60s Acidic ribosomal protein API5 PF05918.11 EFA85913.1 - 4.7e-76 256.7 19.9 5.9e-40 137.6 1.2 3.1 1 1 2 3 3 3 3 Apoptosis inhibitory protein 5 (API5) IFN-gamma PF00714.17 EFA85913.1 - 0.00027 20.8 0.5 0.00088 19.1 0.0 2.1 2 0 0 2 2 2 1 Interferon gamma V_ATPase_I PF01496.19 EFA85913.1 - 0.00074 17.6 1.7 0.0013 16.8 1.7 1.3 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family EPL1 PF10513.9 EFA85913.1 - 0.051 14.0 8.6 0.11 12.8 8.6 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF3446 PF11928.8 EFA85913.1 - 0.1 12.9 2.1 0.36 11.2 2.1 1.9 1 0 0 1 1 1 0 Early growth response N-terminal domain DUF4820 PF16091.5 EFA85913.1 - 0.93 8.8 4.7 2.1 7.6 4.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Sporozoite_P67 PF05642.11 EFA85913.1 - 3.3 5.7 14.1 0.75 7.8 1.2 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Menin PF05053.13 EFA85913.1 - 6.8 4.9 13.2 13 4.0 13.2 1.4 1 0 0 1 1 1 0 Menin SecA_DEAD PF07517.14 EFA85914.1 - 2.7e-20 72.8 0.0 2.8e-18 66.2 0.0 2.7 1 1 0 1 1 1 1 SecA DEAD-like domain Bact_lectin PF18483.1 EFA85914.1 - 1.7e-17 64.1 5.1 6.2e-16 59.0 1.3 3.2 2 1 0 2 2 2 1 Bacterial lectin Pkinase PF00069.25 EFA85914.1 - 8.9e-08 31.8 6.3 2.2e-05 23.9 0.0 3.2 3 0 0 3 3 3 2 Protein kinase domain DUF3638 PF12340.8 EFA85914.1 - 0.0025 17.2 1.7 0.0036 16.7 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) Laminin_G_2 PF02210.24 EFA85914.1 - 0.0034 17.9 0.0 2.1 8.9 0.0 3.0 2 0 0 2 2 2 1 Laminin G domain SecA_PP_bind PF01043.20 EFA85914.1 - 0.0042 17.7 0.0 0.024 15.3 0.0 2.5 1 0 0 1 1 1 1 SecA preprotein cross-linking domain TPR_11 PF13414.6 EFA85914.1 - 0.14 11.8 0.1 0.31 10.7 0.1 1.6 1 0 0 1 1 1 0 TPR repeat DUF4225 PF13988.6 EFA85914.1 - 0.22 11.1 1.1 0.74 9.4 1.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) TPR_1 PF00515.28 EFA85914.1 - 0.23 11.3 1.3 0.67 9.9 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Mt_ATP-synt_B PF05405.14 EFA85914.1 - 0.3 10.7 8.5 5.8 6.5 7.3 3.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Nefa_Nip30_N PF10187.9 EFA85914.1 - 0.7 10.3 14.5 0.16 12.3 10.2 2.3 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 GSH_synthase PF03199.15 EFA85914.1 - 1.7 9.1 5.3 0.52 10.8 0.1 3.1 2 0 0 2 2 1 0 Eukaryotic glutathione synthase CBM49 PF09478.10 EFA85915.1 - 1.9e-16 60.2 0.1 2.5e-16 59.7 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Beach PF02138.18 EFA85916.1 - 2.3e-39 135.4 0.7 2.3e-39 135.4 0.7 1.9 2 0 0 2 2 2 1 Beige/BEACH domain Pkinase PF00069.25 EFA85916.1 - 3.3e-11 43.1 0.1 2.3e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain WD40 PF00400.32 EFA85916.1 - 2.5e-07 31.3 9.8 0.00042 21.1 0.0 5.6 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85916.1 - 0.00024 21.4 0.0 0.31 11.4 0.0 3.9 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Kinase-like PF14531.6 EFA85916.1 - 0.11 11.8 0.0 0.32 10.3 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Hat1_N PF10394.9 EFA85916.1 - 0.21 11.8 5.2 0.053 13.8 0.4 2.3 2 0 0 2 2 2 0 Histone acetyl transferase HAT1 N-terminus CBM49 PF09478.10 EFA85917.1 - 1.9e-16 60.2 0.1 2.5e-16 59.7 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Nop PF01798.18 EFA85918.1 - 2.5e-80 269.3 0.4 2.5e-80 269.3 0.4 3.1 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFA85918.1 - 2.3e-18 66.3 1.9 2.3e-18 66.3 1.9 3.4 2 1 0 2 2 2 1 NOP5NT (NUC127) domain DUF2104 PF09877.9 EFA85918.1 - 0.17 12.2 0.0 1.3 9.4 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2104) AA_permease_2 PF13520.6 EFA85919.1 - 4.8e-28 98.1 24.2 6.6e-28 97.7 24.2 1.2 1 0 0 1 1 1 1 Amino acid permease Menin PF05053.13 EFA85919.1 - 2 6.7 5.0 2.7 6.2 5.0 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 EFA85919.1 - 2.9 8.5 13.1 5.3 7.7 13.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF1451 PF07295.11 EFA85920.1 - 0.036 14.1 8.1 0.063 13.3 7.5 1.6 1 1 1 2 2 2 0 Zinc-ribbon containing domain DUF2087 PF09860.9 EFA85920.1 - 0.16 12.2 0.9 0.28 11.3 0.2 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) Pro_isomerase PF00160.21 EFA85921.1 - 2.1e-50 171.1 1.0 5.6e-50 169.7 0.4 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EFA85921.1 - 6.4e-06 26.8 0.1 0.017 15.9 0.1 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85921.1 - 6.8e-05 23.1 0.0 0.68 10.3 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Bystin PF05291.11 EFA85922.1 - 7.8e-64 215.8 0.5 7.8e-64 215.8 0.5 2.3 2 1 1 3 3 3 1 Bystin MSP1_C PF07462.11 EFA85922.1 - 0.076 11.7 2.4 0.11 11.2 2.4 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF2624 PF11116.8 EFA85922.1 - 0.12 13.3 0.7 0.39 11.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) BID PF06393.11 EFA85922.1 - 3 7.3 5.9 0.92 9.0 0.0 2.6 3 0 0 3 3 3 0 BH3 interacting domain (BID) XRN_N PF03159.18 EFA85923.1 - 6.1e-29 101.1 0.9 2e-26 92.9 0.9 2.6 1 1 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus WI12 PF07107.11 EFA85923.1 - 0.18 11.9 0.9 13 5.9 0.4 2.6 2 0 0 2 2 2 0 Wound-induced protein WI12 GTP_EFTU PF00009.27 EFA85924.1 - 2.4e-31 108.8 3.1 1.1e-29 103.4 3.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFA85924.1 - 2e-18 66.5 0.0 7.8e-18 64.5 0.0 2.1 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EFA85924.1 - 1.1e-08 35.1 0.8 4e-08 33.3 0.3 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EFA85924.1 - 7.4e-06 25.6 0.1 1.7e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 Ras family GTP_EFTU_D2 PF03144.25 EFA85924.1 - 9.7e-06 25.9 2.0 9.7e-06 25.9 2.0 2.9 4 0 0 4 4 4 1 Elongation factor Tu domain 2 SRPRB PF09439.10 EFA85924.1 - 8.1e-05 22.1 0.2 0.00028 20.3 0.2 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 EFA85924.1 - 0.00024 21.0 4.9 0.0006 19.7 2.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Roc PF08477.13 EFA85924.1 - 0.00036 20.7 0.1 0.00077 19.7 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFA85924.1 - 0.026 14.2 1.1 0.053 13.3 0.2 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EFA85924.1 - 0.35 10.9 10.7 2 8.4 0.0 4.0 3 1 1 4 4 4 0 Dynamin family PBP1_TM PF14812.6 EFA85924.1 - 0.71 10.3 6.4 1.6 9.1 2.5 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 EFA85924.1 - 6.2 6.8 13.5 1 9.4 5.0 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4504 PF14953.6 EFA85925.1 - 4.2e-13 49.3 1.8 4.2e-13 49.3 1.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4504) NmrA PF05368.13 EFA85925.1 - 4.7e-11 42.7 0.0 1.1e-10 41.5 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family Mucin PF01456.17 EFA85925.1 - 0.0027 17.7 12.1 0.0049 16.9 12.1 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.11 EFA85925.1 - 0.092 10.9 10.8 0.16 10.2 10.8 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF2407_C PF13373.6 EFA85925.1 - 0.25 11.5 1.3 0.54 10.4 1.3 1.5 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF3439 PF11921.8 EFA85925.1 - 0.52 10.3 15.9 0.18 11.8 12.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Vps51 PF08700.11 EFA85926.1 - 5.5e-26 90.5 2.2 5.5e-26 90.5 2.2 3.1 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.6 EFA85926.1 - 3.9e-15 56.2 8.0 3.9e-15 56.2 8.0 3.8 4 0 0 4 4 4 1 Exocyst complex component Sec5 Dor1 PF04124.12 EFA85926.1 - 4.6e-09 35.4 9.4 4.6e-09 35.4 9.4 2.7 3 0 0 3 3 3 1 Dor1-like family Vps54_N PF10475.9 EFA85926.1 - 7.8e-08 31.9 13.7 7.8e-08 31.9 13.7 2.2 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 EFA85926.1 - 0.00039 20.5 5.6 0.00062 19.9 0.0 3.8 4 1 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 SUIM_assoc PF16619.5 EFA85926.1 - 0.052 13.6 0.2 1.1 9.4 0.1 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Exonuc_VII_S PF02609.16 EFA85926.1 - 0.053 13.6 2.5 0.15 12.2 0.1 3.1 3 0 0 3 3 3 0 Exonuclease VII small subunit COG5 PF10392.9 EFA85926.1 - 0.22 11.7 14.7 0.036 14.3 2.1 3.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Peptidase_C1 PF00112.23 EFA85927.1 - 2.1e-57 194.7 3.5 4.2e-57 193.7 3.5 1.5 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFA85927.1 - 3.6e-13 49.7 2.7 3.6e-13 49.7 2.7 3.0 4 0 0 4 4 4 1 Cathepsin propeptide inhibitor domain (I29) Ank_2 PF12796.7 EFA85929.1 - 1.5e-41 140.9 7.4 3.8e-07 30.6 0.2 7.6 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA85929.1 - 3.7e-39 132.3 10.4 0.00044 20.5 0.1 14.0 6 5 9 15 15 15 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA85929.1 - 3e-35 120.1 14.5 1.2e-05 25.7 0.1 11.4 6 4 6 12 12 12 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA85929.1 - 1.7e-31 104.7 2.9 0.046 14.3 0.0 14.4 14 1 1 15 15 15 7 Ankyrin repeat Ank PF00023.30 EFA85929.1 - 7.1e-05 23.1 0.4 0.26 11.8 0.2 5.7 7 1 1 8 8 8 1 Ankyrin repeat DUF5049 PF16468.5 EFA85929.1 - 0.004 17.0 7.5 30 4.6 0.0 7.3 8 3 0 8 8 8 0 Domain of unknown function (DUF5049) DUF3447 PF11929.8 EFA85929.1 - 0.11 12.4 30.5 3.8 7.5 5.4 7.0 3 2 4 8 8 8 0 Domain of unknown function (DUF3447) Ndc80_HEC PF03801.13 EFA85929.1 - 0.21 11.2 4.7 1 9.0 0.5 3.5 4 0 0 4 4 4 0 HEC/Ndc80p family Telomerase_RBD PF12009.8 EFA85929.1 - 0.9 9.6 10.7 1.9 8.6 0.9 3.7 4 0 0 4 4 4 0 Telomerase ribonucleoprotein complex - RNA binding domain NST1 PF13945.6 EFA85930.1 - 1.7e-59 201.2 45.0 1.7e-59 201.2 45.0 9.3 4 2 3 7 7 7 1 Salt tolerance down-regulator tRNA-synt_2 PF00152.20 EFA85931.1 - 1.6e-90 303.4 1.2 2e-90 303.1 1.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFA85931.1 - 1.6e-07 31.2 0.6 4.6e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain SUIM_assoc PF16619.5 EFA85931.1 - 0.031 14.3 7.0 0.075 13.1 7.0 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 tRNA-synt_2d PF01409.20 EFA85931.1 - 0.037 13.5 0.0 1.3 8.4 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) HGD-D PF06050.13 EFA85931.1 - 0.1 12.3 0.0 0.29 10.8 0.0 1.7 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component IL2 PF00715.17 EFA85932.1 - 0.61 10.0 6.8 0.89 9.5 5.2 2.1 1 1 1 2 2 2 0 Interleukin 2 Pkinase PF00069.25 EFA85933.1 - 2.1e-52 178.1 0.0 2.5e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA85933.1 - 6.4e-27 94.5 0.0 8.9e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EFA85933.1 - 7.1e-24 84.3 0.3 1.4e-23 83.4 0.1 1.6 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EFA85933.1 - 2.7e-08 34.2 0.3 5.2e-07 30.0 0.3 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EFA85933.1 - 1.1e-06 28.7 0.0 2.1e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 EFA85933.1 - 7.6e-06 26.5 0.1 1.6e-05 25.5 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain PH_8 PF15409.6 EFA85933.1 - 0.00022 21.5 0.6 0.001 19.3 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Kinase-like PF14531.6 EFA85933.1 - 0.02 14.2 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PH_9 PF15410.6 EFA85933.1 - 0.059 13.7 0.1 0.18 12.2 0.0 1.9 2 1 0 2 2 2 0 Pleckstrin homology domain APH PF01636.23 EFA85933.1 - 0.075 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFA85933.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Phosphorylase PF00343.20 EFA85934.1 - 0 1050.1 1.6 0 1049.9 1.6 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase PCI PF01399.27 EFA85935.1 - 2.4e-19 69.8 2.6 1.6e-18 67.1 0.1 2.8 2 1 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EFA85935.1 - 2.9e-15 56.1 0.2 6.7e-15 54.9 0.2 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain MutS_III PF05192.18 EFA85935.1 - 0.12 12.6 2.6 0.13 12.5 1.0 1.9 1 1 1 2 2 2 0 MutS domain III Phage_Treg PF04761.12 EFA85935.1 - 0.15 12.2 0.3 1 9.5 0.0 2.5 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator OEP PF02321.18 EFA85935.1 - 2.8 7.7 7.3 11 5.7 4.7 2.4 2 0 0 2 2 2 0 Outer membrane efflux protein PseudoU_synth_2 PF00849.22 EFA85936.1 - 5.8e-31 107.7 0.0 5.8e-31 107.7 0.0 2.7 3 1 0 3 3 3 1 RNA pseudouridylate synthase S4 PF01479.25 EFA85936.1 - 0.0032 17.1 0.1 0.0092 15.7 0.1 1.8 1 0 0 1 1 1 1 S4 domain Macoilin PF09726.9 EFA85936.1 - 0.008 14.8 16.7 0.01 14.5 16.7 1.2 1 0 0 1 1 1 1 Macoilin family Mucin PF01456.17 EFA85936.1 - 0.88 9.6 23.8 0.076 13.0 6.5 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Hid1 PF12722.7 EFA85936.1 - 1.5 6.8 15.2 2.1 6.4 15.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 EFA85936.1 - 2.2 8.0 16.2 4.2 7.1 16.2 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SSP160 PF06933.11 EFA85936.1 - 7.3 4.7 17.6 0.41 8.8 5.2 2.2 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 DDE_Tnp_4 PF13359.6 EFA85938.1 - 5.1e-23 81.5 0.0 8.7e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA85938.1 - 8.5e-07 28.8 0.7 3.3e-06 26.9 0.0 2.1 2 1 0 2 2 2 1 Transposase DDE domain zf-met PF12874.7 EFA85939.1 - 0.0039 17.5 1.5 0.009 16.4 0.8 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type MRNIP PF15749.5 EFA85939.1 - 0.0091 16.7 0.1 0.013 16.2 0.1 1.3 1 0 0 1 1 1 1 MRN-interacting protein Spc24 PF08286.11 EFA85939.1 - 0.015 15.5 0.4 0.021 15.1 0.4 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Lectin_N PF03954.14 EFA85939.1 - 0.027 14.2 1.7 0.034 13.9 1.5 1.4 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain COG2 PF06148.11 EFA85939.1 - 0.029 14.4 0.3 0.043 13.9 0.3 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TolA_bind_tri PF16331.5 EFA85939.1 - 0.033 14.3 0.2 0.049 13.7 0.2 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation BRE1 PF08647.11 EFA85939.1 - 0.053 13.6 1.9 0.053 13.6 1.9 1.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase zf-BED PF02892.15 EFA85939.1 - 0.08 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_jaz PF12171.8 EFA85939.1 - 0.087 13.1 2.5 0.097 13.0 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4969 PF16339.5 EFA85940.1 - 2.8 8.4 5.9 24 5.3 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4969) UDPGP PF01704.18 EFA85941.1 - 4.9e-180 598.6 1.0 6.1e-180 598.3 1.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Phage_CI_C PF16452.5 EFA85941.1 - 0.063 13.6 0.1 0.61 10.4 0.0 2.6 3 0 0 3 3 3 0 Bacteriophage CI repressor C-terminal domain CRAL_TRIO_2 PF13716.6 EFA85942.1 - 0.092 12.9 0.2 0.21 11.7 0.1 1.6 1 1 1 2 2 2 0 Divergent CRAL/TRIO domain TPT PF03151.16 EFA85943.1 - 3e-07 30.1 10.0 3.4e-07 29.9 10.0 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFA85943.1 - 4.3e-07 30.2 12.3 4.9e-07 30.0 12.3 1.0 1 0 0 1 1 1 1 EamA-like transporter family SelK_SelG PF10961.8 EFA85943.1 - 0.05 14.2 0.3 0.081 13.5 0.3 1.4 1 0 0 1 1 1 0 Selenoprotein SelK_SelG FAM176 PF14851.6 EFA85943.1 - 0.068 12.8 0.3 0.092 12.4 0.3 1.2 1 0 0 1 1 1 0 FAM176 family DUF2070 PF09843.9 EFA85943.1 - 1.7 6.9 14.9 1.8 6.7 14.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Edc3_linker PF16598.5 EFA85944.1 - 0.42 11.3 7.7 0.17 12.5 3.3 2.1 1 1 1 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 DUF688 PF05097.12 EFA85944.1 - 1.3 8.1 9.1 0.64 9.1 7.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF688) RhoGAP PF00620.27 EFA85945.1 - 7.6e-12 45.3 0.1 7.6e-12 45.3 0.1 2.7 3 0 0 3 3 3 1 RhoGAP domain Chorion_2 PF03964.15 EFA85945.1 - 0.072 13.9 0.3 0.072 13.9 0.3 2.1 2 0 0 2 2 2 0 Chorion family 2 ECH_2 PF16113.5 EFA85946.1 - 1.1e-106 357.1 0.0 2e-106 356.3 0.0 1.4 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFA85946.1 - 1e-26 93.8 0.1 5.8e-26 91.3 0.0 2.1 2 1 1 3 3 3 1 Enoyl-CoA hydratase/isomerase DUF829 PF05705.14 EFA85947.1 - 6.2e-43 147.4 0.1 1.1e-42 146.6 0.1 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF2933 PF11666.8 EFA85947.1 - 0.0081 16.2 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2933) Phage-tail_2 PF09096.10 EFA85947.1 - 0.044 13.8 0.1 0.15 12.0 0.0 1.9 3 0 0 3 3 3 0 Baseplate structural protein, domain 2 FSH1 PF03959.13 EFA85947.1 - 0.06 13.0 0.0 0.093 12.4 0.0 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Ctf8 PF09696.10 EFA85948.1 - 1.8e-09 38.1 0.0 9.2e-09 35.8 0.0 1.9 1 1 1 2 2 2 2 Ctf8 TIG PF01833.24 EFA85949.1 - 5.3e-12 45.7 8.9 0.00078 19.5 0.0 4.4 3 1 1 4 4 4 3 IPT/TIG domain LRR_8 PF13855.6 EFA85949.1 - 6.3e-09 35.5 17.9 4.3e-05 23.2 2.1 4.1 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFA85949.1 - 6.2e-07 29.6 10.4 1.2e-05 25.6 1.0 5.0 4 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFA85949.1 - 9.2e-05 22.5 10.6 1.1 10.0 0.3 7.4 7 0 0 7 7 7 1 Leucine Rich Repeat Apc13p PF05839.11 EFA85949.1 - 0.00046 20.3 1.0 0.0015 18.7 1.0 1.9 1 1 0 1 1 1 1 Apc13p protein LRR_6 PF13516.6 EFA85949.1 - 0.0019 18.1 17.0 0.036 14.1 1.1 6.3 6 0 0 6 6 6 1 Leucine Rich repeat AAA_assoc PF14363.6 EFA85951.1 - 0.054 13.8 0.5 0.18 12.1 0.5 2.0 2 0 0 2 2 2 0 Domain associated at C-terminal with AAA SAB PF04382.13 EFA85951.1 - 0.076 13.1 0.4 0.24 11.5 0.4 1.9 1 0 0 1 1 1 0 SAB domain WD40_alt PF14077.6 EFA85951.1 - 0.091 12.6 0.5 0.19 11.6 0.5 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif Macoilin PF09726.9 EFA85951.1 - 3.8 5.9 33.8 0.083 11.4 23.0 2.0 2 0 0 2 2 2 0 Macoilin family Presenilin PF01080.17 EFA85951.1 - 8.4 5.0 9.2 14 4.3 9.2 1.5 1 0 0 1 1 1 0 Presenilin Pro_isomerase PF00160.21 EFA85952.1 - 5.4e-46 156.7 0.2 6.6e-46 156.5 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4330 PF14221.6 EFA85953.1 - 0.13 12.5 0.4 1.8 8.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4330) F-box_5 PF18511.1 EFA85954.1 - 1.6e-07 30.8 0.0 3.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 F-box EGF_2 PF07974.13 EFA85954.1 - 8.5e-05 22.8 10.9 0.00018 21.8 10.9 1.6 1 0 0 1 1 1 1 EGF-like domain F-box-like PF12937.7 EFA85954.1 - 0.0056 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like Laminin_EGF PF00053.24 EFA85954.1 - 0.017 15.2 4.4 0.056 13.6 4.4 1.8 1 0 0 1 1 1 0 Laminin EGF domain EGF PF00008.27 EFA85954.1 - 0.98 9.8 8.0 2.3 8.6 8.0 1.7 1 0 0 1 1 1 0 EGF-like domain FAA_hydrolase PF01557.18 EFA85955.1 - 5.5e-57 192.9 0.0 7.9e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EFA85955.1 - 2.6e-31 107.9 0.0 1.1e-30 106.0 0.0 2.0 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal bZIP_2 PF07716.15 EFA85957.1 - 8.7e-08 32.1 7.5 8.7e-08 32.1 7.5 3.0 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 EFA85957.1 - 2.3e-06 27.6 8.5 2.3e-06 27.6 8.5 2.7 2 0 0 2 2 2 1 bZIP transcription factor DUF3439 PF11921.8 EFA85957.1 - 0.048 13.6 5.9 0.064 13.2 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) FH2 PF02181.23 EFA85959.1 - 6.9e-75 252.5 13.5 6.9e-75 252.5 13.5 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain DUF3682 PF12446.8 EFA85959.1 - 0.022 15.2 2.6 0.022 15.2 2.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3682) ORC_WH_C PF18137.1 EFA85959.1 - 0.5 10.4 8.5 1.9 8.6 8.5 1.9 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal PRIMA1 PF16101.5 EFA85959.1 - 7.8 6.6 9.6 23 5.1 9.6 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 UEV PF05743.13 EFA85960.1 - 4.2e-26 91.2 0.3 1e-25 90.0 0.3 1.7 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EFA85960.1 - 3.4e-24 84.6 0.7 3.4e-24 84.6 0.7 2.1 2 0 0 2 2 2 1 Vps23 core domain UQ_con PF00179.26 EFA85960.1 - 0.0001 22.0 0.8 0.0001 22.0 0.8 2.0 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme SUIM_assoc PF16619.5 EFA85960.1 - 0.00038 20.5 9.5 2.4 8.3 5.6 3.7 3 1 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 APG6_N PF17675.1 EFA85960.1 - 0.0085 16.6 15.9 0.0096 16.4 13.0 2.4 2 1 0 2 2 2 1 Apg6 coiled-coil region Prok-E2_B PF14461.6 EFA85960.1 - 0.02 14.6 0.2 0.054 13.2 0.2 1.7 1 0 0 1 1 1 0 Prokaryotic E2 family B Ndc1_Nup PF09531.10 EFA85960.1 - 1.1 7.9 12.2 1.5 7.5 12.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GLTSCR1 PF15249.6 EFA85962.1 - 4.3e-08 33.5 0.5 4.3e-08 33.5 0.5 5.3 5 1 1 6 6 6 1 Conserved region of unknown function on GLTSCR protein MJ1316 PF04457.12 EFA85964.1 - 2.8e-13 50.4 0.2 1.5e-12 48.1 0.2 2.2 1 1 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain CE2_N PF17996.1 EFA85965.1 - 2e-14 53.5 0.0 3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Lipase_GDSL_2 PF13472.6 EFA85965.1 - 3.4e-13 50.4 1.1 1e-12 48.9 1.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFA85965.1 - 6.9e-13 49.0 0.0 1.1e-12 48.3 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ParcG PF10274.9 EFA85966.1 - 0.0048 17.0 5.3 0.62 10.1 1.1 2.4 1 1 1 2 2 2 2 Parkin co-regulated protein YtxH PF12732.7 EFA85966.1 - 0.17 12.5 4.6 4.6 7.9 1.5 2.9 1 1 1 2 2 2 0 YtxH-like protein ABC_tran_CTD PF16326.5 EFA85966.1 - 0.94 9.8 5.7 1.1 9.5 0.1 2.8 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF1664 PF07889.12 EFA85966.1 - 1.9 8.5 11.0 13 5.9 1.4 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 EFA85966.1 - 7.8 7.0 11.9 2.6 8.5 2.6 3.0 2 1 1 3 3 3 0 Snapin/Pallidin PP2C PF00481.21 EFA85967.1 - 2.4e-30 106.1 0.4 2.4e-30 106.1 0.4 2.2 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 EFA85967.1 - 4.1e-07 29.9 0.0 4.2e-05 23.3 0.0 2.9 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EFA85967.1 - 0.031 14.2 0.1 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) SapB_2 PF03489.17 EFA85967.1 - 0.055 13.6 1.9 0.13 12.4 1.9 1.7 1 0 0 1 1 1 0 Saposin-like type B, region 2 MAT1 PF06391.13 EFA85967.1 - 0.16 11.8 8.0 0.47 10.2 8.0 1.8 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 EF-hand_like PF09279.11 EFA85967.1 - 0.41 11.2 1.7 1.2 9.7 0.2 2.6 3 0 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like Snf7 PF03357.21 EFA85968.1 - 2.7e-28 98.7 24.8 2.7e-28 98.7 24.8 1.3 1 1 0 1 1 1 1 Snf7 PIEZO PF15917.5 EFA85968.1 - 0.18 11.3 11.3 0.061 12.8 8.8 1.4 1 1 0 1 1 1 0 Piezo Snapin_Pallidin PF14712.6 EFA85968.1 - 4.8 7.7 16.9 4.3 7.8 4.2 3.1 1 1 3 4 4 4 0 Snapin/Pallidin YlqD PF11068.8 EFA85968.1 - 7.2 7.0 18.5 1 9.8 11.0 2.1 1 1 1 2 2 2 0 YlqD protein Ribosomal_L22e PF01776.17 EFA85969.1 - 2.2e-44 150.3 2.0 2.8e-44 150.0 2.0 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Choline_transpo PF04515.12 EFA85970.1 - 7.5e-64 216.0 40.7 7.5e-64 216.0 40.7 2.8 1 1 1 2 2 2 1 Plasma-membrane choline transporter WD40 PF00400.32 EFA85972.1 - 7.1e-14 52.0 7.1 0.0094 16.8 0.0 7.8 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA85972.1 - 9.9e-09 35.4 0.0 0.0048 17.2 0.0 5.5 5 3 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFA85972.1 - 0.0091 15.9 0.2 35 4.5 0.0 3.7 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Orn_Arg_deC_N PF02784.16 EFA85973.1 - 3.5e-30 105.2 0.0 4.5e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFA85973.1 - 8.8e-19 67.6 0.0 8.8e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain PMP22_Claudin PF00822.20 EFA85974.1 - 0.0025 17.7 5.5 0.044 13.7 5.2 2.3 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Orf78 PF06024.12 EFA85974.1 - 0.012 15.9 6.8 5.3 7.4 0.3 3.4 2 1 1 3 3 3 0 Orf78 (ac78) DUF2569 PF10754.9 EFA85974.1 - 0.018 15.5 11.0 0.076 13.5 8.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) V_ATPase_I PF01496.19 EFA85974.1 - 0.055 11.4 3.2 0.068 11.1 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ECSCR PF15820.5 EFA85974.1 - 0.27 11.1 9.6 0.8 9.6 0.0 3.1 2 1 1 3 3 3 0 Endothelial cell-specific chemotaxis regulator DUF4381 PF14316.6 EFA85974.1 - 0.64 10.3 0.1 0.64 10.3 0.1 1.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) DUF2207 PF09972.9 EFA85974.1 - 1.7 7.3 8.7 4.3 6.0 0.0 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Claudin_2 PF13903.6 EFA85974.1 - 1.9 8.2 10.0 0.38 10.5 5.5 2.0 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Vpu PF00558.19 EFA85974.1 - 3 7.7 6.6 2.6 7.9 2.2 2.4 2 0 0 2 2 2 0 Vpu protein Hum_adeno_E3A PF05393.11 EFA85974.1 - 8.8 6.4 9.4 9.7 6.2 0.4 3.0 3 0 0 3 3 3 0 Human adenovirus early E3A glycoprotein ATP-synt_Eps PF04627.13 EFA85977.1 - 1.2e-19 70.0 0.2 1.4e-19 69.8 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Abhydro_lipase PF04083.16 EFA85978.1 - 4.4e-23 80.6 0.0 7.8e-23 79.8 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFA85978.1 - 8.7e-13 48.5 0.5 1.3e-09 38.1 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Daxx PF03344.15 EFA85978.1 - 0.22 11.6 0.1 0.41 10.7 0.1 1.3 1 0 0 1 1 1 0 Daxx N-terminal Rassf1C-interacting domain O-antigen_lig PF13425.6 EFA85979.1 - 0.0047 15.8 0.0 0.0054 15.6 0.0 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein ABA_GPCR PF12430.8 EFA85979.1 - 0.011 15.5 0.9 0.014 15.2 0.9 1.1 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor Pkinase_Tyr PF07714.17 EFA85981.1 - 4.3e-56 190.1 0.0 7.7e-56 189.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA85981.1 - 8.8e-45 153.1 0.0 5.4e-44 150.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain PH PF00169.29 EFA85981.1 - 0.00028 21.4 0.0 0.0071 16.8 0.0 3.3 3 1 0 3 3 3 1 PH domain Kdo PF06293.14 EFA85981.1 - 0.066 12.6 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFA85981.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.8 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Drf_GBD PF06371.13 EFA85981.1 - 0.32 10.6 0.0 0.32 10.6 0.0 2.4 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain ASH PF15780.5 EFA85981.1 - 4.7 7.5 9.7 4.1 7.7 0.1 3.5 3 0 0 3 3 3 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TPT PF03151.16 EFA85982.1 - 1e-16 61.2 15.9 1e-15 57.8 6.8 2.1 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EFA85982.1 - 2.3e-06 27.8 14.9 3.7e-06 27.1 14.9 1.3 1 1 0 1 1 1 1 EamA-like transporter family UAA PF08449.11 EFA85982.1 - 0.022 14.0 7.6 0.018 14.3 6.6 1.3 1 1 0 1 1 1 0 UAA transporter family SLC35F PF06027.12 EFA85982.1 - 0.024 14.1 9.5 0.029 13.9 9.5 1.1 1 0 0 1 1 1 0 Solute carrier family 35 Nuc_sug_transp PF04142.15 EFA85982.1 - 0.051 12.7 10.2 0.058 12.6 10.2 1.0 1 0 0 1 1 1 0 Nucleotide-sugar transporter DUF2070 PF09843.9 EFA85982.1 - 0.83 7.9 7.1 0.96 7.7 7.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Na_Ca_ex PF01699.24 EFA85983.1 - 5.5e-15 55.6 30.6 5.3e-11 42.7 13.6 2.5 2 0 0 2 2 2 2 Sodium/calcium exchanger protein YukC PF10140.9 EFA85983.1 - 0.015 14.1 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF4956 PF16316.5 EFA85983.1 - 0.027 14.1 3.4 0.057 13.1 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4956) SR-25 PF10500.9 EFA85983.1 - 0.5 9.9 7.3 0.81 9.3 7.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 EFA85983.1 - 1.1 9.9 10.0 0.33 11.6 0.3 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Branch PF02485.21 EFA85984.1 - 6.4e-17 61.9 1.8 2.6e-16 59.9 1.8 2.0 1 1 0 1 1 1 1 Core-2/I-Branching enzyme EGF_2 PF07974.13 EFA85984.1 - 0.16 12.4 1.3 0.34 11.3 1.3 1.5 1 0 0 1 1 1 0 EGF-like domain rhaM PF05336.13 EFA85985.1 - 4.4e-26 91.0 1.4 4.4e-26 91.0 1.4 2.2 2 0 0 2 2 2 1 L-rhamnose mutarotase TraB PF01963.17 EFA85985.1 - 1.6e-16 61.0 6.2 6.6e-14 52.4 0.0 2.8 4 0 0 4 4 4 2 TraB family Androgen_recep PF02166.16 EFA85985.1 - 2 7.2 8.0 3.5 6.4 8.0 1.3 1 0 0 1 1 1 0 Androgen receptor CDC45 PF02724.14 EFA85985.1 - 4.8 5.4 23.2 9.9 4.3 23.2 1.6 1 0 0 1 1 1 0 CDC45-like protein EGF_2 PF07974.13 EFA85986.1 - 0.00043 20.6 12.0 0.00043 20.6 12.0 2.2 2 0 0 2 2 2 1 EGF-like domain EphA2_TM PF14575.6 EFA85986.1 - 0.13 13.1 0.2 0.26 12.2 0.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.10 EFA85986.1 - 0.18 11.2 3.7 0.37 10.2 3.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EGF PF00008.27 EFA85986.1 - 2 8.8 9.0 5.3 7.4 9.0 1.7 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 EFA85987.1 - 0.00042 20.6 12.0 0.00042 20.6 12.0 2.2 2 0 0 2 2 2 1 EGF-like domain Adeno_E3_CR2 PF02439.15 EFA85987.1 - 0.064 13.0 0.3 0.064 13.0 0.3 2.3 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 EFA85987.1 - 0.085 13.7 0.2 0.18 12.7 0.2 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 EFA85987.1 - 0.092 11.6 0.1 0.16 10.8 0.1 1.3 1 0 0 1 1 1 0 Amnionless EGF PF00008.27 EFA85987.1 - 1.8 8.9 9.0 5.1 7.5 9.0 1.8 1 0 0 1 1 1 0 EGF-like domain SKG6 PF08693.10 EFA85987.1 - 9.3 5.8 11.7 0.19 11.2 4.0 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Autophagy_act_C PF03987.15 EFA85988.1 - 6.3e-17 61.9 2.8 7.4e-17 61.7 1.5 1.9 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Translin PF01997.16 EFA85988.1 - 0.029 14.4 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Translin family 2OG-FeII_Oxy_2 PF13532.6 EFA85989.1 - 2.5e-11 44.1 1.3 2.6e-10 40.8 0.1 2.4 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily BRF1 PF07741.13 EFA85989.1 - 2.9 8.3 8.0 0.32 11.4 1.0 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain 2OG-FeII_Oxy_2 PF13532.6 EFA85990.1 - 2.3e-25 89.9 0.0 2.6e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TrmO PF01980.16 EFA85991.1 - 8.5e-36 122.8 2.4 2.6e-23 82.5 0.1 2.5 1 1 1 2 2 2 2 tRNA-methyltransferase O Crystall_3 PF08964.10 EFA85991.1 - 3.8 7.7 7.9 0.48 10.6 0.3 3.1 4 0 0 4 4 4 0 Beta/Gamma crystallin Shufflon_N PF04917.12 EFA85992.1 - 0.0016 18.0 0.7 0.0024 17.4 0.7 1.2 1 0 0 1 1 1 1 Bacterial shufflon protein, N-terminal constant region zf-B_box PF00643.24 EFA85992.1 - 0.0025 18.0 8.8 0.005 17.0 8.8 1.5 1 0 0 1 1 1 1 B-box zinc finger Kelch_6 PF13964.6 EFA85992.1 - 0.0096 16.2 0.1 0.058 13.7 0.1 2.3 2 0 0 2 2 2 1 Kelch motif zf-UBR PF02207.20 EFA85992.1 - 0.15 12.3 4.3 0.26 11.5 4.3 1.4 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Germane PF10646.9 EFA85992.1 - 0.31 11.9 2.6 0.41 11.4 1.6 1.7 2 0 0 2 2 2 0 Sporulation and spore germination FlgN PF05130.12 EFA85992.1 - 3.5 8.1 10.1 0.31 11.6 4.2 2.2 2 1 1 3 3 3 0 FlgN protein Methyltransf_12 PF08242.12 EFA85993.1 - 1.5e-13 51.4 0.1 5.3e-13 49.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFA85993.1 - 2.3e-12 47.1 0.1 3.3e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA85993.1 - 3.4e-10 40.5 0.0 9.9e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA85993.1 - 6.1e-09 36.4 0.0 1.2e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA85993.1 - 1.4e-07 31.4 0.0 2.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA85993.1 - 0.002 17.5 0.0 0.0028 17.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EFA85993.1 - 0.0027 17.6 0.0 0.0052 16.7 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase DUF3419 PF11899.8 EFA85993.1 - 0.005 16.1 0.3 0.059 12.5 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3419) MTS PF05175.14 EFA85993.1 - 0.0065 16.0 0.0 0.017 14.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFA85993.1 - 0.031 13.8 0.1 0.41 10.1 0.0 2.4 3 0 0 3 3 3 0 Putative methyltransferase ubiquitin PF00240.23 EFA85994.1 - 2.6e-159 517.3 26.1 1.2e-32 111.5 0.6 5.0 5 0 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 EFA85994.1 - 2.1e-72 238.9 25.0 8.4e-15 54.4 0.6 5.0 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA85994.1 - 8.7e-23 80.6 14.5 0.00094 19.6 0.1 7.2 5 5 0 5 5 5 4 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA85994.1 - 3.8e-16 59.2 10.7 0.055 13.8 0.1 5.2 5 0 0 5 5 5 5 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA85994.1 - 4.1e-16 59.1 3.5 0.3 11.2 0.0 6.0 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFA85994.1 - 1.2e-14 54.7 2.2 0.69 10.5 0.0 5.2 1 1 2 5 5 5 5 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 EFA85994.1 - 1.7e-14 53.5 5.6 0.086 12.8 0.0 5.1 5 0 0 5 5 5 4 TANK binding kinase 1 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFA85994.1 - 4.3e-09 36.4 0.7 7.5 6.4 0.0 5.1 1 1 4 5 5 5 0 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 EFA85994.1 - 1.9e-07 31.4 0.0 40 4.7 0.0 5.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) Ubiquitin_4 PF18036.1 EFA85994.1 - 2.4e-07 30.7 27.9 17 5.6 0.3 9.9 9 1 0 9 9 9 0 Ubiquitin-like domain Big_3_3 PF13750.6 EFA85994.1 - 4.5e-07 29.7 0.1 17 5.1 0.0 5.1 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 3) Methyltrans_RNA PF04452.14 EFA85994.1 - 5.2e-07 29.2 2.7 2.4 7.5 0.0 4.2 4 0 0 4 4 4 3 RNA methyltransferase UDP-g_GGTase PF06427.11 EFA85994.1 - 1.8e-05 24.8 7.8 9.7 6.4 0.1 4.9 5 0 0 5 5 5 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EFA85994.1 - 3.1e-05 23.5 0.1 19 4.6 0.0 4.8 4 1 1 5 5 5 0 Protein of unknown function (DUF969) YcgR_2 PF12945.7 EFA85994.1 - 7.6e-05 22.8 8.8 11 6.2 0.0 5.2 5 0 0 5 5 5 0 Flagellar protein YcgR Big_7 PF17957.1 EFA85994.1 - 0.00012 22.7 0.2 1.5e+02 3.2 0.0 5.0 5 0 0 5 5 5 0 Bacterial Ig domain DUF3861 PF12977.7 EFA85994.1 - 0.00021 21.4 1.5 48 4.2 0.0 4.5 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 EFA85994.1 - 0.0005 19.9 5.7 56 3.7 0.0 5.2 5 0 0 5 5 5 0 ACT domain ORF11CD3 PF10549.9 EFA85994.1 - 0.00069 19.7 2.2 1.2e+02 2.9 0.0 6.3 10 0 0 10 10 5 0 ORF11CD3 domain DUF3435 PF11917.8 EFA85994.1 - 0.0011 18.0 0.5 29 3.4 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3435) ACT_4 PF13291.6 EFA85994.1 - 0.0023 18.5 0.5 2.5e+02 2.4 0.0 5.0 5 0 0 5 5 5 0 ACT domain Corona_NS2A PF05213.12 EFA85994.1 - 0.0041 16.5 0.1 59 2.9 0.0 4.0 4 0 0 4 4 4 0 Coronavirus NS2A protein Imm12 PF15560.6 EFA85994.1 - 0.0052 16.7 3.8 1e+02 2.8 0.0 4.9 5 0 0 5 5 5 0 Immunity protein 12 NEAT PF05031.12 EFA85994.1 - 0.012 16.2 8.4 16 6.2 0.7 4.6 2 1 2 4 4 4 0 Iron Transport-associated domain Phage-tail_1 PF09097.10 EFA85994.1 - 0.017 14.9 0.3 42 3.8 0.0 4.4 5 0 0 5 5 5 0 Baseplate structural protein, domain 1 Myosin_N PF02736.19 EFA85994.1 - 0.16 11.8 8.5 1.4e+02 2.4 0.0 6.2 5 0 0 5 5 5 0 Myosin N-terminal SH3-like domain Glyco_tran_WecB PF03808.13 EFA85994.1 - 0.18 11.7 0.0 2.8e+02 1.4 0.0 4.1 4 1 0 4 4 4 0 Glycosyl transferase WecB/TagA/CpsF family bPH_3 PF14470.6 EFA85994.1 - 0.23 11.9 14.2 14 6.2 0.1 5.2 6 0 0 6 6 6 0 Bacterial PH domain ProRS-C_2 PF09181.10 EFA85994.1 - 5 7.3 7.0 2.6e+02 1.8 0.1 4.3 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal PH_15 PF17339.2 EFA85994.1 - 8.8 6.3 11.0 1.2e+02 2.6 0.1 4.4 5 0 0 5 5 5 0 PH domain SpoU_methylase PF00588.19 EFA85995.1 - 4.4e-26 91.7 0.0 1.4e-25 90.1 0.0 1.9 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF5377 PF17347.2 EFA85995.1 - 0.025 14.9 0.1 0.58 10.6 0.0 3.1 2 0 0 2 2 2 0 Family of unknown function (DUF5377) DUF4038 PF13204.6 EFA85995.1 - 0.12 12.0 0.0 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4038) Phosphoesterase PF04185.14 EFA85997.1 - 4.4e-79 266.3 4.5 7.4e-79 265.5 4.5 1.3 1 0 0 1 1 1 1 Phosphoesterase family Latarcin PF10279.9 EFA85998.1 - 0.48 10.9 3.8 0.19 12.1 0.5 2.1 3 0 0 3 3 3 0 Latarcin precursor RsgA_GTPase PF03193.16 EFA85999.1 - 2.7e-07 30.7 0.3 3.1e-07 30.5 0.3 1.1 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EFA85999.1 - 3.5e-07 30.3 0.1 3.6e-07 30.2 0.1 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFA85999.1 - 7.5e-07 28.7 0.2 7.9e-07 28.6 0.2 1.0 1 0 0 1 1 1 1 AIG1 family FeoB_N PF02421.18 EFA85999.1 - 0.0023 17.5 0.2 0.0028 17.2 0.2 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 EFA85999.1 - 0.007 16.9 0.1 0.0071 16.9 0.1 1.1 1 0 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 EFA85999.1 - 0.0073 16.4 1.8 0.67 10.0 0.8 2.0 1 1 1 2 2 2 2 Dynamin family NTPase_1 PF03266.15 EFA85999.1 - 0.026 14.4 0.3 0.031 14.2 0.3 1.1 1 0 0 1 1 1 0 NTPase RNA_helicase PF00910.22 EFA85999.1 - 0.054 13.9 0.0 0.066 13.6 0.0 1.2 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 EFA85999.1 - 0.056 13.2 0.1 0.12 12.1 0.1 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 EFA85999.1 - 0.1 13.0 0.1 0.1 13.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFA85999.1 - 0.11 13.0 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EFA85999.1 - 0.16 11.4 0.0 0.18 11.2 0.0 1.0 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF4407 PF14362.6 EFA86000.1 - 0.015 14.6 16.7 0.02 14.3 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mit_ribos_Mrp51 PF11709.8 EFA86000.1 - 0.097 12.2 6.6 0.12 12.0 6.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit XRN_M PF17846.1 EFA86000.1 - 0.19 10.6 15.6 0.23 10.4 15.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain HTH_Tnp_Tc3_1 PF11427.8 EFA86000.1 - 0.4 10.6 3.2 0.23 11.4 0.6 1.9 2 0 0 2 2 2 0 Tc3 transposase DUF2730 PF10805.8 EFA86000.1 - 0.41 10.8 10.3 0.17 11.9 5.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF3584 PF12128.8 EFA86000.1 - 1.5 6.2 24.6 1.9 5.9 24.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Exonuc_VII_L PF02601.15 EFA86000.1 - 2.2 7.7 14.4 2.9 7.4 14.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EFA86000.1 - 3.1 5.6 22.5 3.3 5.5 22.0 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family CALCOCO1 PF07888.11 EFA86000.1 - 3.4 6.4 28.8 4.2 6.1 28.8 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like G-alpha PF00503.20 EFA86001.1 - 4.8e-93 312.1 1.5 7.9e-93 311.4 1.5 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFA86001.1 - 8.3e-14 51.4 0.1 2e-09 37.1 0.0 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EFA86001.1 - 0.0022 18.2 0.0 2.7 8.2 0.0 2.8 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFA86001.1 - 0.0034 16.8 1.4 0.19 11.0 0.1 2.5 3 0 0 3 3 3 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFA86001.1 - 0.046 13.8 0.0 7.3 6.7 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase LRR_4 PF12799.7 EFA86003.1 - 1.1e-05 25.7 16.6 0.16 12.5 0.8 6.3 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFA86003.1 - 0.00056 19.8 20.4 3 8.1 0.0 9.3 11 0 0 11 11 11 2 Leucine Rich repeat LRR_8 PF13855.6 EFA86003.1 - 0.069 12.9 8.0 0.13 12.1 0.8 4.4 3 1 1 4 4 4 0 Leucine rich repeat LRR_1 PF00560.33 EFA86003.1 - 0.46 11.2 13.0 28 5.8 0.2 8.0 7 2 0 7 7 7 0 Leucine Rich Repeat Torus PF16131.5 EFA86004.1 - 4.2e-30 104.6 0.9 4.2e-30 104.6 0.9 3.6 2 1 1 3 3 3 1 Torus domain RRM_1 PF00076.22 EFA86004.1 - 1.2e-06 28.2 0.0 2.6e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EFA86004.1 - 0.00047 20.1 0.8 0.00085 19.3 0.8 1.5 1 0 0 1 1 1 1 Zinc finger domain PEX11 PF05648.14 EFA86004.1 - 0.037 13.5 1.1 0.085 12.3 1.1 1.5 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) zf-CCCH_4 PF18044.1 EFA86004.1 - 0.086 12.7 3.3 0.15 11.9 3.3 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Pox_Ag35 PF03286.14 EFA86004.1 - 6 6.6 22.2 17 5.2 22.2 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MRPL52 PF18699.1 EFA86005.1 - 1e-26 92.9 10.8 1.2e-25 89.5 2.1 3.2 2 0 0 2 2 2 2 Mitoribosomal protein mL52 RT_RNaseH_2 PF17919.1 EFA86005.1 - 3.5e-21 75.1 0.0 8.8e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EFA86005.1 - 3.7e-20 72.2 0.0 1.1e-19 70.6 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EFA86005.1 - 6.5e-18 65.1 0.0 1.4e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EFA86005.1 - 3e-10 39.8 1.8 1.1e-09 38.1 1.8 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 EFA86005.1 - 0.042 13.6 0.3 0.2 11.4 0.1 2.4 2 0 0 2 2 2 0 Integrase core domain DUF5341 PF17276.2 EFA86005.1 - 0.085 13.0 1.6 0.25 11.5 1.6 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5341) DUF3576 PF12100.8 EFA86005.1 - 0.18 11.9 2.2 2.1 8.5 0.9 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3576) PRKCSH_1 PF13015.6 EFA86006.1 - 7.2e-07 29.0 0.1 1.3e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 EFA86006.1 - 0.0039 17.3 6.8 0.081 13.0 1.4 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat zf-4CXXC_R1 PF10497.9 EFA86008.1 - 0.0004 20.6 8.3 0.0004 20.6 8.3 2.1 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-HC5HC2H_2 PF13832.6 EFA86008.1 - 3.7 7.7 15.7 1.5 9.0 5.3 3.5 3 0 0 3 3 3 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EFA86008.1 - 6.8 7.0 20.8 0.021 15.1 6.1 3.6 3 1 1 4 4 4 0 PHD-like zinc-binding domain LRR_6 PF13516.6 EFA86011.1 - 4.4e-17 60.6 6.9 1.9e-05 24.3 0.0 4.8 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 EFA86011.1 - 2.2e-07 30.5 0.0 0.48 11.2 0.0 4.7 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_4 PF12799.7 EFA86011.1 - 0.0003 21.1 4.0 1.4 9.4 0.1 4.4 2 2 2 4 4 4 2 Leucine Rich repeats (2 copies) TAN PF11640.8 EFA86011.1 - 0.018 15.2 0.5 3.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair HTH_AsnC-type PF13404.6 EFA86011.1 - 0.029 14.2 0.1 1.3 8.9 0.1 3.0 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain LRR_8 PF13855.6 EFA86011.1 - 0.044 13.6 4.7 9.6 6.1 0.0 3.9 4 0 0 4 4 4 0 Leucine rich repeat EF-hand_7 PF13499.6 EFA86013.1 - 1.8e-15 57.2 0.2 2e-09 37.8 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFA86013.1 - 1.9e-14 52.2 0.2 1.1e-05 24.9 0.2 3.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFA86013.1 - 3.1e-14 51.4 0.6 0.0019 17.6 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFA86013.1 - 1e-05 25.2 2.1 0.0002 21.1 0.1 2.7 2 2 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EFA86013.1 - 0.0001 21.6 2.1 0.15 11.6 0.2 2.8 3 0 0 3 3 3 2 EF hand EFhand_Ca_insen PF08726.10 EFA86013.1 - 0.00054 20.0 0.0 0.002 18.2 0.0 1.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_9 PF14658.6 EFA86013.1 - 0.0012 19.1 0.0 0.078 13.3 0.0 2.4 1 1 2 3 3 3 1 EF-hand domain CHAD PF05235.14 EFA86013.1 - 0.007 16.4 0.0 0.0085 16.1 0.0 1.1 1 0 0 1 1 1 1 CHAD domain DUF5580 PF17743.1 EFA86013.1 - 0.026 13.1 0.0 0.031 12.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) DUF2666 PF10869.8 EFA86013.1 - 0.029 14.6 0.1 0.34 11.1 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) EF-hand_11 PF08976.11 EFA86013.1 - 0.034 15.0 0.0 0.048 14.5 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_4 PF12763.7 EFA86013.1 - 0.051 13.5 0.1 6.8 6.7 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF1179 PF06678.11 EFA86014.1 - 0.039 14.0 0.1 0.079 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) CCDC-167 PF15188.6 EFA86016.1 - 1 9.8 6.7 2.1 8.8 6.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF2034 PF10356.9 EFA86017.1 - 0.0038 16.7 0.1 0.0078 15.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) MMR_HSR1 PF01926.23 EFA86018.1 - 2.4e-15 56.6 0.0 2.9e-13 49.9 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFA86018.1 - 1.4e-07 31.1 0.0 8e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFA86018.1 - 1.5e-05 25.0 0.0 0.0039 17.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EFA86018.1 - 0.009 16.1 0.0 0.009 16.1 0.0 4.4 4 2 0 4 4 4 1 Dynamin family Roc PF08477.13 EFA86018.1 - 0.037 14.2 0.1 0.6 10.3 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFA86018.1 - 0.11 12.3 0.0 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_pol_Rpc4 PF05132.14 EFA86018.1 - 0.7 10.3 0.0 0.7 10.3 0.0 5.3 4 2 0 4 4 4 0 RNA polymerase III RPC4 SPATA3 PF15662.5 EFA86018.1 - 3 8.4 0.0 3 8.4 0.0 4.6 4 1 1 5 5 5 0 Spermatogenesis-associated protein 3 family DUF1748 PF08520.10 EFA86019.1 - 7e-14 51.5 0.1 1e-13 51.0 0.1 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Sybindin PF04099.12 EFA86020.1 - 7.1e-40 136.2 1.3 1.3e-39 135.4 1.3 1.4 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFA86020.1 - 4.3e-05 23.6 0.3 6.8e-05 23.0 0.3 1.4 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region zf-C3HC4_3 PF13920.6 EFA86021.1 - 1.8e-11 43.7 5.2 2.8e-11 43.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA86021.1 - 5.6e-10 39.4 9.8 1.2e-09 38.3 9.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA86021.1 - 2.2e-08 33.8 9.4 4.5e-08 32.8 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA86021.1 - 2.5e-08 33.6 6.5 5e-08 32.7 6.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFA86021.1 - 5e-08 32.7 10.1 9.5e-08 31.8 10.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFA86021.1 - 1.1e-07 32.0 5.0 4.6e-07 30.0 5.0 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFA86021.1 - 3.2e-07 30.2 6.2 7.1e-07 29.1 6.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA86021.1 - 8.8e-06 25.6 7.5 1.5e-05 24.8 7.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFA86021.1 - 0.00093 19.3 10.3 0.0018 18.4 10.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EFA86021.1 - 0.0021 17.9 3.8 0.0062 16.4 3.8 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EFA86021.1 - 0.0066 16.6 3.7 0.016 15.3 3.7 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EFA86021.1 - 0.038 14.0 3.7 0.12 12.4 3.7 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFA86021.1 - 0.056 13.1 6.1 0.13 11.9 6.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-P11 PF03854.14 EFA86021.1 - 0.58 9.9 4.2 15 5.3 5.2 2.4 1 1 1 2 2 2 0 P-11 zinc finger zf-RING_4 PF14570.6 EFA86021.1 - 0.81 9.5 6.8 2.1 8.2 6.8 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3535 PF12054.8 EFA86022.1 - 1.5e-85 288.1 2.2 1.5e-85 288.1 2.2 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EFA86022.1 - 4e-48 163.9 0.0 4.9e-47 160.3 0.0 2.5 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFA86022.1 - 2.1e-17 63.5 0.4 2.8e-16 59.8 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HEAT PF02985.22 EFA86022.1 - 3.9e-12 45.3 5.2 0.15 12.4 0.0 10.1 10 0 0 10 10 10 2 HEAT repeat HEAT_EZ PF13513.6 EFA86022.1 - 4.1e-08 33.6 7.2 3.9e-06 27.2 0.0 4.9 6 0 0 6 6 6 1 HEAT-like repeat HEAT_2 PF13646.6 EFA86022.1 - 4.5e-07 30.2 4.5 0.0026 18.1 0.2 5.6 4 1 2 6 6 6 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EFA86022.1 - 4.3e-06 27.2 1.1 0.00064 20.3 0.0 3.3 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EFA86022.1 - 0.018 15.0 0.8 4.9 7.0 0.1 4.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3385) PXA PF02194.15 EFA86022.1 - 0.047 13.7 2.9 11 5.9 0.0 3.8 3 0 0 3 3 3 0 PXA domain Cnd1 PF12717.7 EFA86022.1 - 0.54 10.3 10.3 3.8 7.5 0.2 4.9 5 1 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 zf-C2H2 PF00096.26 EFA86023.1 - 0.024 15.1 3.0 0.024 15.1 3.0 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFA86023.1 - 3.1 8.9 20.9 0.12 13.3 1.8 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger PNISR PF15996.5 EFA86023.1 - 8.3 6.6 21.5 3.5 7.8 18.0 1.9 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR FNIP PF05725.12 EFA86024.1 - 5.8e-06 26.4 12.0 0.05 13.8 0.1 6.7 4 2 2 6 6 6 4 FNIP Repeat zf-C3HC4_2 PF13923.6 EFA86025.1 - 4.4e-11 42.4 11.5 8.8e-11 41.5 11.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA86025.1 - 3.6e-09 36.4 11.4 8.7e-09 35.1 11.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 EFA86025.1 - 9.4e-08 31.6 1.0 1.5e-07 31.0 0.1 1.9 2 0 0 2 2 2 1 SAP domain zf-RING_5 PF14634.6 EFA86025.1 - 1.4e-07 31.4 10.4 2.5e-07 30.6 10.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFA86025.1 - 3.4e-07 30.2 6.5 3.4e-07 30.2 6.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFA86025.1 - 5.8e-07 29.3 7.1 9.3e-07 28.6 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFA86025.1 - 8.7e-07 29.2 10.5 1.7e-06 28.3 10.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 EFA86025.1 - 9.7e-07 28.6 2.6 1.8e-06 27.7 2.6 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EFA86025.1 - 4.6e-05 23.5 12.7 9.4e-05 22.5 12.7 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EFA86025.1 - 0.0069 16.4 4.5 0.013 15.5 4.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFA86025.1 - 0.016 15.0 8.3 0.037 13.8 8.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EFA86025.1 - 0.035 14.4 10.4 0.14 12.4 10.4 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFA86025.1 - 0.093 12.6 13.1 0.77 9.7 13.1 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EFA86025.1 - 2.7 7.9 8.4 7.5 6.5 8.4 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Utp14 PF04615.13 EFA86025.1 - 7.8 4.9 39.3 0.15 10.6 22.2 2.0 2 0 0 2 2 2 0 Utp14 protein PCO_ADO PF07847.12 EFA86026.1 - 2.1e-34 118.7 0.2 3.1e-34 118.2 0.2 1.2 1 0 0 1 1 1 1 PCO_ADO DUF3116 PF11313.8 EFA86026.1 - 0.051 13.4 1.9 0.52 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3116) RGS PF00615.19 EFA86028.1 - 2.4e-22 79.4 0.9 2.4e-22 79.4 0.9 4.1 4 0 0 4 4 4 1 Regulator of G protein signaling domain LRR_8 PF13855.6 EFA86028.1 - 8.9e-19 67.0 9.3 4.1e-11 42.5 3.0 2.9 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFA86028.1 - 4.2e-13 49.3 12.6 4.1e-07 30.2 0.7 4.5 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFA86028.1 - 0.0023 17.5 0.7 0.0023 17.5 0.7 2.9 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EFA86028.1 - 1.1 9.5 6.3 26 5.2 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EFA86028.1 - 1.2 10.0 21.4 13 6.8 0.1 7.3 6 1 0 6 6 6 0 Leucine Rich Repeat Ank_2 PF12796.7 EFA86029.1 - 9.5e-06 26.1 0.0 0.00067 20.2 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA86029.1 - 0.00018 21.7 0.9 3.6 8.5 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFA86029.1 - 0.0011 19.5 0.8 0.52 11.0 0.1 4.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) HTH_11 PF08279.12 EFA86029.1 - 0.038 13.9 0.4 0.16 11.9 0.1 2.2 2 0 0 2 2 2 0 HTH domain Bact_lectin PF18483.1 EFA86030.1 - 4.3e-20 72.6 4.1 3.6e-14 53.3 0.2 3.3 2 1 0 2 2 2 2 Bacterial lectin SecA_DEAD PF07517.14 EFA86030.1 - 4.1e-19 69.0 0.0 2.6e-18 66.3 0.0 2.1 1 1 0 1 1 1 1 SecA DEAD-like domain Laminin_G_2 PF02210.24 EFA86030.1 - 6.6e-07 29.9 0.9 0.082 13.5 0.1 3.8 4 0 0 4 4 4 2 Laminin G domain DUF3638 PF12340.8 EFA86030.1 - 4.7e-05 22.8 0.6 4.7e-05 22.8 0.6 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3638) Laminin_G_1 PF00054.23 EFA86030.1 - 0.00036 20.7 0.1 0.2 11.9 0.1 2.7 2 0 0 2 2 2 2 Laminin G domain Pkinase PF00069.25 EFA86030.1 - 0.00047 19.6 1.9 0.00064 19.2 0.2 2.2 2 0 0 2 2 2 1 Protein kinase domain TPR_17 PF13431.6 EFA86030.1 - 0.0067 16.7 1.0 1.2 9.7 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF4225 PF13988.6 EFA86030.1 - 0.028 14.0 1.0 0.08 12.5 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) SecA_PP_bind PF01043.20 EFA86030.1 - 0.064 13.9 0.0 0.36 11.5 0.0 2.4 1 0 0 1 1 1 0 SecA preprotein cross-linking domain ResIII PF04851.15 EFA86030.1 - 0.083 12.9 4.5 0.51 10.3 0.1 4.1 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit TPR_11 PF13414.6 EFA86030.1 - 0.086 12.5 1.4 0.22 11.2 1.4 1.8 1 0 0 1 1 1 0 TPR repeat DUF4132 PF13569.6 EFA86030.1 - 0.15 11.9 0.2 0.44 10.3 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) Peptidase_M66 PF10462.9 EFA86031.1 - 3.4e-24 85.3 0.1 1.4e-23 83.3 0.1 1.9 2 0 0 2 2 2 1 Peptidase M66 Reprolysin_5 PF13688.6 EFA86031.1 - 0.0097 16.1 0.1 0.022 14.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EFA86031.1 - 0.14 12.7 0.2 0.47 11.0 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Dicty_CTDC PF00526.18 EFA86033.1 - 6.6e-119 387.2 293.6 5.5e-10 39.0 12.9 17.6 17 0 0 17 17 17 16 Dictyostelium (slime mold) repeat Peptidase_M66 PF10462.9 EFA86034.1 - 5.5e-33 114.2 0.0 1e-32 113.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M66 EGF_2 PF07974.13 EFA86035.1 - 0.00024 21.4 9.9 0.00024 21.4 9.9 1.7 2 0 0 2 2 2 1 EGF-like domain Amnionless PF14828.6 EFA86035.1 - 0.014 14.2 0.1 0.022 13.6 0.1 1.3 1 0 0 1 1 1 0 Amnionless DUF4690 PF15756.5 EFA86035.1 - 0.022 15.3 1.5 0.041 14.5 0.1 2.2 2 0 0 2 2 2 0 Small Novel Rich in Cartilage EGF PF00008.27 EFA86035.1 - 0.026 14.8 6.3 0.049 13.9 6.3 1.4 1 0 0 1 1 1 0 EGF-like domain Pox_EPC_I2-L1 PF12575.8 EFA86035.1 - 0.087 13.1 0.2 0.29 11.4 0.2 1.9 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 hEGF PF12661.7 EFA86035.1 - 1 10.1 8.4 2.5 8.9 8.4 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF Toxin_2 PF00451.19 EFA86035.1 - 1.4 9.3 7.6 2.9 8.3 7.6 1.5 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 TSP_C PF05735.12 EFA86036.1 - 0.022 14.7 0.6 1.1 9.2 0.3 2.3 2 0 0 2 2 2 0 Thrombospondin C-terminal region EGF_2 PF07974.13 EFA86037.1 - 0.00074 19.8 7.6 0.0022 18.3 7.6 1.8 1 0 0 1 1 1 1 EGF-like domain Toxin_2 PF00451.19 EFA86037.1 - 0.038 14.3 5.5 0.077 13.3 5.5 1.5 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 EGF PF00008.27 EFA86037.1 - 0.054 13.8 4.0 0.14 12.5 4.0 1.7 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFA86037.1 - 1.7 9.4 6.6 5.2 7.8 6.6 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF LRR_6 PF13516.6 EFA86038.1 - 3.9e-16 57.6 11.3 2.4e-05 24.0 0.1 5.4 5 0 0 5 5 5 4 Leucine Rich repeat F-box-like PF12937.7 EFA86038.1 - 9.8e-05 22.2 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFA86038.1 - 0.00057 19.7 0.1 0.0038 17.1 0.1 2.3 1 1 1 2 2 2 1 F-box domain T6SS_HCP PF05638.12 EFA86038.1 - 0.0036 17.7 0.3 0.011 16.1 0.1 1.7 1 1 1 2 2 2 1 Type VI secretion system effector, Hcp LRR_4 PF12799.7 EFA86038.1 - 0.0062 16.9 5.3 0.2 12.1 0.0 3.9 3 2 1 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFA86038.1 - 0.031 14.0 4.4 0.92 9.3 0.6 4.0 3 1 1 4 4 4 0 Leucine rich repeat PHB_acc_N PF07879.11 EFA86038.1 - 0.18 11.9 0.8 2.3 8.4 0.1 2.8 3 0 0 3 3 3 0 PHB/PHA accumulation regulator DNA-binding domain EGF_Tenascin PF18720.1 EFA86039.1 - 0.0018 18.3 1.9 0.0064 16.5 1.9 2.0 1 0 0 1 1 1 1 Tenascin EGF domain hEGF PF12661.7 EFA86039.1 - 1.3 9.8 9.0 3.2 8.5 9.0 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF FYVE PF01363.21 EFA86040.1 - 6.9e-22 77.4 12.0 8.4e-22 77.1 12.0 1.1 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 EFA86040.1 - 0.0032 17.7 8.1 0.0042 17.3 8.1 1.2 1 0 0 1 1 1 1 FYVE-type zinc finger DUF4637 PF15470.6 EFA86040.1 - 0.053 13.2 2.9 0.075 12.8 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DZR PF12773.7 EFA86040.1 - 0.28 11.2 10.4 13 5.9 2.2 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-AN1 PF01428.16 EFA86040.1 - 2 8.7 15.0 4.7 7.5 11.4 2.6 1 1 1 2 2 2 0 AN1-like Zinc finger TPR_1 PF00515.28 EFA86041.1 - 1.1e-26 91.4 21.4 1.3e-06 28.0 0.1 7.9 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86041.1 - 1.2e-23 81.2 20.0 5.8e-05 22.9 0.1 8.3 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86041.1 - 8.3e-18 63.1 17.2 0.023 14.9 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86041.1 - 3.3e-17 62.6 7.6 5.9e-09 36.1 0.7 5.6 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFA86041.1 - 1.7e-15 55.8 3.5 0.00019 21.2 0.0 5.7 5 1 1 6 6 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA86041.1 - 1.5e-12 47.6 17.2 1.8e-11 44.1 0.8 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFA86041.1 - 3.3e-12 46.1 0.2 0.38 11.7 0.0 6.1 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFA86041.1 - 4.8e-12 46.3 0.0 0.00035 21.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFA86041.1 - 3.7e-11 42.5 10.6 0.00065 19.3 0.0 5.8 5 1 1 6 6 6 3 TPR repeat TPR_17 PF13431.6 EFA86041.1 - 3.9e-11 42.5 2.6 0.0012 19.1 0.1 6.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86041.1 - 1.4e-10 41.6 0.8 0.04 14.4 0.0 4.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFA86041.1 - 2.5e-10 39.9 1.8 0.0011 18.7 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_3 PF07720.12 EFA86041.1 - 0.00041 20.3 0.1 0.00041 20.3 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA86041.1 - 0.00094 19.7 10.4 0.49 11.1 0.0 6.8 8 0 0 8 8 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA86041.1 - 0.019 15.0 3.8 9.4 6.4 0.4 5.0 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat EST1_DNA_bind PF10373.9 EFA86041.1 - 0.02 14.4 16.7 0.097 12.1 0.8 3.6 3 0 0 3 3 3 0 Est1 DNA/RNA binding domain TPR_MalT PF17874.1 EFA86041.1 - 0.035 13.5 0.3 11 5.3 0.0 2.9 2 1 0 2 2 2 0 MalT-like TPR region TPR_9 PF13371.6 EFA86041.1 - 0.037 14.2 0.0 9.3 6.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EFA86041.1 - 0.1 12.7 8.5 12 6.0 0.0 5.5 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 EFA86041.1 - 0.56 11.0 12.1 33 5.3 0.3 6.1 6 1 0 6 6 6 0 Sel1 repeat FPN1 PF06963.12 EFA86042.1 - 1.8e-80 270.7 17.9 2.3e-80 270.3 17.9 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Claudin_2 PF13903.6 EFA86042.1 - 0.077 12.7 0.0 0.077 12.7 0.0 2.4 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Acetyltransf_2 PF00797.17 EFA86042.1 - 0.22 11.3 2.2 17 5.1 0.8 2.2 2 0 0 2 2 2 0 N-acetyltransferase Pribosyltran PF00156.27 EFA86043.1 - 3.5e-22 78.6 0.1 4.1e-22 78.4 0.1 1.0 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Avl9 PF09794.9 EFA86044.1 - 8.4e-65 218.9 3.8 1.1e-49 169.2 0.2 3.0 2 2 1 3 3 3 2 Transport protein Avl9 Afi1 PF07792.12 EFA86044.1 - 0.00029 21.3 0.0 0.00029 21.3 0.0 3.4 2 1 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2347 PF09804.9 EFA86044.1 - 0.00078 19.1 0.1 0.00078 19.1 0.1 2.6 2 1 1 3 3 3 1 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 EFA86044.1 - 0.15 12.0 0.7 2.6 8.0 0.1 2.6 2 0 0 2 2 2 0 DENN (AEX-3) domain TPR_17 PF13431.6 EFA86045.1 - 1.1e-61 200.9 11.5 8.8e-09 35.1 0.0 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 EFA86045.1 - 1.1e-12 47.4 22.4 0.58 9.9 0.1 8.3 9 0 0 9 9 9 6 TPR repeat Anth_Ig PF05587.13 EFA86045.1 - 8.3e-06 26.1 0.4 15 5.9 0.0 4.6 4 0 0 4 4 4 3 Anthrax receptor extracellular domain CTXphi_pIII-N1 PF16710.5 EFA86045.1 - 0.0061 16.6 0.3 0.93 9.6 0.0 3.7 3 2 2 5 5 5 1 N-terminal N1 domain of Vibrio phage CTXphi pIII DUF5432 PF17497.2 EFA86045.1 - 0.0086 16.2 0.0 2.9 8.1 0.0 2.5 2 0 0 2 2 2 2 Family of unknown function (DUF5432) TPR_1 PF00515.28 EFA86045.1 - 0.29 11.0 23.0 3.6 7.6 0.1 9.3 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86045.1 - 1.3 9.3 9.7 43 4.6 0.1 7.2 10 0 0 10 10 10 0 Tetratricopeptide repeat Pex14_N PF04695.13 EFA86046.1 - 0.063 13.9 3.7 0.07 13.8 3.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TF_Otx PF03529.13 EFA86046.1 - 1.5 9.2 10.5 1.2 9.5 9.1 1.5 1 1 0 1 1 1 0 Otx1 transcription factor Zip PF02535.22 EFA86047.1 - 2.8 7.1 4.2 4.2 6.5 4.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4337 PF14235.6 EFA86047.1 - 6.7 6.8 7.4 11 6.1 7.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Actin PF00022.19 EFA86049.1 - 3.3e-113 378.4 0.0 4.3e-60 203.4 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFA86049.1 - 0.0022 16.9 0.0 0.029 13.2 0.0 2.5 1 1 0 1 1 1 1 MreB/Mbl protein RT_RNaseH PF17917.1 EFA86050.1 - 2.8e-25 88.6 0.2 6e-24 84.4 0.0 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EFA86050.1 - 1.2e-24 86.2 0.0 8.3e-23 80.3 0.0 3.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EFA86050.1 - 7.4e-20 71.4 0.2 2.3e-19 69.8 0.2 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EFA86050.1 - 4.6e-14 52.3 0.1 1e-13 51.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EFA86050.1 - 2.2e-11 44.0 0.0 8.4e-11 42.1 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 EFA86050.1 - 4.9e-05 23.2 0.0 0.00015 21.6 0.0 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Asp_protease_2 PF13650.6 EFA86050.1 - 0.00028 21.5 0.0 0.0012 19.4 0.0 2.2 1 0 0 1 1 1 1 Aspartyl protease zf-H2C2 PF09337.10 EFA86050.1 - 0.00096 19.3 1.2 0.0017 18.5 0.2 2.1 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 EFA86050.1 - 0.015 15.1 0.2 0.45 10.3 0.0 3.3 2 0 0 2 2 2 0 Integrase core domain gag-asp_proteas PF13975.6 EFA86050.1 - 0.032 14.8 0.0 0.12 13.0 0.0 2.1 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF16 PF01519.16 EFA86050.1 - 5.4 7.6 7.5 6 7.4 0.5 3.8 3 1 0 3 3 3 0 Protein of unknown function DUF16 Zip PF02535.22 EFA86050.1 - 6.8 5.8 5.3 16 4.6 5.3 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Dus PF01207.17 EFA86051.1 - 1.4e-46 159.0 0.0 1.9e-35 122.5 0.0 2.0 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) Aldolase_II PF00596.21 EFA86052.1 - 6.6e-43 146.8 0.0 8.6e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Sulfotransfer_3 PF13469.6 EFA86052.1 - 0.11 12.9 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family Peptidase_M15_4 PF13539.6 EFA86052.1 - 0.15 12.5 0.0 1.3 9.6 0.0 2.2 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase FNIP PF05725.12 EFA86053.1 - 6.1e-29 99.9 27.4 6.7e-07 29.4 0.7 7.5 6 2 2 8 8 8 7 FNIP Repeat F-box-like PF12937.7 EFA86053.1 - 0.0052 16.6 0.7 0.02 14.8 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 EFA86053.1 - 0.031 13.8 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 F-box EMC1_C PF07774.13 EFA86054.1 - 2.1e-55 187.7 1.2 3.7e-55 186.9 1.2 1.4 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal FNIP PF05725.12 EFA86054.1 - 2e-22 79.1 19.2 7e-06 26.1 0.2 6.8 5 1 2 7 7 7 6 FNIP Repeat PQQ_2 PF13360.6 EFA86054.1 - 7.6e-05 22.4 0.1 0.00045 19.9 0.0 2.1 2 0 0 2 2 2 1 PQQ-like domain Flavoprotein PF02441.19 EFA86057.1 - 2.4e-49 167.1 0.3 3.1e-49 166.8 0.3 1.0 1 0 0 1 1 1 1 Flavoprotein Pkinase PF00069.25 EFA86058.1 - 4.3e-68 229.5 0.0 4.3e-68 229.5 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86058.1 - 1.4e-32 113.0 0.0 1.4e-32 113.0 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase TFIIA PF03153.13 EFA86058.1 - 0.021 14.9 40.1 0.037 14.0 40.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 EFA86058.1 - 0.14 10.9 17.6 0.17 10.6 17.6 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFA86058.1 - 0.38 9.9 11.8 0.45 9.7 11.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EFA86058.1 - 3.4 6.1 18.5 4.4 5.7 18.5 1.1 1 0 0 1 1 1 0 Macoilin family Otopetrin PF03189.13 EFA86058.1 - 4.7 5.9 11.7 9 5.0 11.7 1.4 1 0 0 1 1 1 0 Otopetrin Exonuc_VII_L PF02601.15 EFA86058.1 - 5.3 6.5 20.5 7.1 6.1 20.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4045 PF13254.6 EFA86058.1 - 6.7 6.2 16.0 8.7 5.9 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PAT1 PF09770.9 EFA86058.1 - 7.5 4.7 38.1 10 4.2 38.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spc7 PF08317.11 EFA86059.1 - 0.00061 18.8 15.4 0.00061 18.8 15.4 18.6 3 1 17 21 21 21 9 Spc7 kinetochore protein ATG16 PF08614.11 EFA86059.1 - 0.0048 17.1 15.7 0.0048 17.1 15.7 20.3 3 2 16 21 21 21 6 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 EFA86059.1 - 0.0068 16.7 17.7 0.0068 16.7 17.7 25.9 8 5 18 27 27 27 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DnaJ PF00226.31 EFA86060.1 - 6.3e-27 93.5 2.5 9e-27 93.0 2.5 1.2 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.9 EFA86060.1 - 6.7e-19 68.5 5.5 9.9e-19 68.0 5.5 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Promethin PF16015.5 EFA86060.1 - 0.012 15.5 8.5 0.012 15.5 8.5 2.1 1 1 0 2 2 2 0 Promethin DUF3341 PF11821.8 EFA86060.1 - 0.028 14.1 1.5 0.046 13.4 1.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3341) DUF1673 PF07895.11 EFA86060.1 - 0.074 12.8 2.9 0.1 12.3 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF4064 PF13273.6 EFA86060.1 - 0.23 11.8 6.8 0.086 13.1 3.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF805 PF05656.14 EFA86060.1 - 0.26 11.7 2.1 0.56 10.7 1.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF805) DUF3671 PF12420.8 EFA86060.1 - 1.2 9.2 8.7 0.14 12.3 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function ABC2_membrane_3 PF12698.7 EFA86060.1 - 2.5 7.1 11.1 3.8 6.5 11.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF702 PF05142.12 EFA86061.1 - 1.9e-05 25.2 4.9 1.9e-05 25.2 4.9 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF702) zf-BED PF02892.15 EFA86061.1 - 0.013 15.5 0.0 0.036 14.1 0.0 1.8 1 0 0 1 1 1 0 BED zinc finger DUF4477 PF14780.6 EFA86061.1 - 0.047 13.3 0.5 0.093 12.3 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) Ndufs5 PF10200.9 EFA86061.1 - 0.086 13.1 0.2 0.31 11.3 0.2 2.0 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF2895 PF11444.8 EFA86061.1 - 0.087 12.2 0.2 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) DUF1539 PF07560.11 EFA86061.1 - 0.33 11.0 4.9 0.12 12.5 1.3 2.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1539) DUF4363 PF14276.6 EFA86061.1 - 0.36 11.0 5.6 0.69 10.1 5.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) DUF1180 PF06679.12 EFA86062.1 - 0.093 13.1 6.3 0.14 12.5 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RIFIN PF02009.16 EFA86062.1 - 3.7 7.4 4.8 4.1 7.2 4.8 1.1 1 0 0 1 1 1 0 Rifin DUF1387 PF07139.11 EFA86062.1 - 3.8 7.2 8.2 4.4 6.9 8.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Mucin PF01456.17 EFA86062.1 - 5.8 6.9 59.9 12 5.9 59.9 1.5 1 1 0 1 1 1 0 Mucin-like glycoprotein Menin PF05053.13 EFA86062.1 - 6.3 5.0 7.6 8.6 4.6 7.6 1.3 1 0 0 1 1 1 0 Menin RIBIOP_C PF04950.12 EFA86063.1 - 1.7e-102 342.8 0.0 1.7e-102 342.8 0.0 2.1 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFA86063.1 - 4.8e-19 68.2 0.2 2.4e-18 66.0 0.2 2.3 1 1 0 1 1 1 1 AARP2CN (NUC121) domain Nop14 PF04147.12 EFA86063.1 - 6.8 4.8 25.2 15 3.7 25.2 1.6 1 0 0 1 1 1 0 Nop14-like family Ank_2 PF12796.7 EFA86064.1 - 5e-27 94.3 3.0 4.7e-06 27.1 0.0 5.8 2 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86064.1 - 4.1e-24 84.6 10.8 0.0005 20.6 0.0 9.7 7 2 4 11 11 11 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86064.1 - 4.1e-14 51.3 6.3 1.8 9.4 0.0 11.6 13 1 1 14 14 14 3 Ankyrin repeat Ank_5 PF13857.6 EFA86064.1 - 1.9e-13 50.3 1.4 3 8.3 0.0 9.5 6 3 4 10 10 10 4 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA86064.1 - 1.9e-05 24.5 5.0 0.013 15.4 0.0 5.6 4 2 3 7 7 7 1 Domain of unknown function (DUF3447) zf-C2H2_8 PF15909.5 EFA86064.1 - 0.021 15.1 0.5 0.051 13.9 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon Dicty_CTDC PF00526.18 EFA86065.1 - 3.4e-64 212.3 206.7 2.3e-10 40.2 12.5 11.5 13 0 0 13 13 13 10 Dictyostelium (slime mold) repeat TPR_6 PF13174.6 EFA86066.1 - 2.7e-07 30.8 1.3 0.11 13.2 0.0 4.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86066.1 - 1.9e-06 27.5 0.7 0.11 12.6 0.0 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86066.1 - 2.8e-05 24.3 1.6 0.33 11.3 0.0 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA86066.1 - 5.1e-05 23.8 0.0 0.69 10.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA86066.1 - 8.3e-05 22.7 0.0 0.01 16.0 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFA86066.1 - 0.00034 21.1 0.0 0.031 14.8 0.0 3.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86066.1 - 0.00065 19.7 0.8 3.5 8.1 0.0 3.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86066.1 - 0.0063 17.2 0.2 1.7 9.7 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86066.1 - 0.0085 15.9 3.3 0.23 11.4 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFA86066.1 - 0.046 13.6 0.1 0.99 9.4 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA86066.1 - 0.078 13.4 0.0 0.31 11.5 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3151 PF11349.8 EFA86066.1 - 0.15 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3151) Ank_4 PF13637.6 EFA86066.1 - 0.17 12.5 0.4 0.73 10.5 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Pyr_redox_2 PF07992.14 EFA86067.1 - 1.8e-36 125.9 0.1 2.2e-36 125.6 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA86067.1 - 3.2e-20 72.5 1.4 2.2e-13 50.6 0.4 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA86067.1 - 3.7e-10 39.5 0.8 5.4e-07 29.2 0.4 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFA86067.1 - 1.5e-09 37.9 0.0 0.016 14.8 0.0 3.3 3 0 0 3 3 3 3 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFA86067.1 - 1.3e-08 34.9 0.0 0.0054 16.9 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DUF1188 PF06690.11 EFA86067.1 - 8.7e-07 28.7 0.1 0.0012 18.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1188) Trp_halogenase PF04820.14 EFA86067.1 - 1.8e-06 27.1 0.8 0.004 16.1 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase K_oxygenase PF13434.6 EFA86067.1 - 4e-06 26.2 0.4 0.032 13.4 0.1 2.3 1 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Sacchrp_dh_NADP PF03435.18 EFA86067.1 - 2.7e-05 24.4 1.1 0.2 11.9 0.1 2.8 3 0 0 3 3 3 2 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EFA86067.1 - 3.6e-05 24.0 0.2 0.46 10.8 0.0 2.8 2 0 0 2 2 2 2 TrkA-N domain Lycopene_cycl PF05834.12 EFA86067.1 - 4.3e-05 22.7 0.0 0.18 10.8 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_7 PF13241.6 EFA86067.1 - 0.00012 22.4 0.3 0.26 11.7 0.0 2.6 3 0 0 3 3 2 2 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EFA86067.1 - 0.00018 21.5 2.6 0.82 9.7 0.0 3.7 2 2 1 4 4 4 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EFA86067.1 - 0.00034 19.5 0.1 0.22 10.2 0.0 2.4 2 0 0 2 2 2 2 HI0933-like protein ApbA PF02558.16 EFA86067.1 - 0.00098 18.8 0.0 0.3 10.7 0.0 2.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EFA86067.1 - 0.0013 18.0 0.0 0.26 10.5 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EFA86067.1 - 0.0019 17.5 0.4 0.67 9.2 0.5 2.5 2 1 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EFA86067.1 - 0.0064 16.4 0.7 0.69 9.8 0.0 2.5 3 0 0 3 3 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EFA86067.1 - 0.07 14.0 0.1 21 6.0 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EFA86067.1 - 0.079 13.4 0.6 4.5 7.7 0.1 2.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain GIDA PF01134.22 EFA86067.1 - 0.09 11.8 0.3 10 5.1 0.2 2.7 2 1 1 3 3 3 0 Glucose inhibited division protein A Spermine_synth PF01564.17 EFA86067.1 - 0.091 12.2 1.3 0.68 9.3 0.6 2.5 2 1 1 3 3 3 0 Spermine/spermidine synthase domain TIG PF01833.24 EFA86068.1 - 1.4e-27 95.6 57.5 1.2e-11 44.5 6.1 7.9 6 2 1 7 7 7 6 IPT/TIG domain Lectin_C PF00059.21 EFA86068.1 - 0.00011 22.8 0.1 0.00034 21.3 0.1 1.8 1 0 0 1 1 1 1 Lectin C-type domain EGF_2 PF07974.13 EFA86068.1 - 0.00073 19.9 8.8 0.0016 18.8 8.8 1.6 1 0 0 1 1 1 1 EGF-like domain Thioredoxin PF00085.20 EFA86069.1 - 7.2e-11 42.0 0.0 1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 EFA86069.1 - 0.048 13.8 0.0 0.094 12.9 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_8 PF13905.6 EFA86069.1 - 0.05 13.9 0.0 0.081 13.3 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 EFA86069.1 - 0.085 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin SpoU_methylase PF00588.19 EFA86070.1 - 4.4e-27 95.0 0.0 1.5e-26 93.3 0.0 2.0 1 0 0 1 1 1 1 SpoU rRNA Methylase family HTH_Tnp_4 PF13613.6 EFA86070.1 - 0.085 12.6 0.0 0.32 10.8 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease DUF4038 PF13204.6 EFA86070.1 - 0.095 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) CAP_GLY PF01302.25 EFA86071.1 - 6.1e-22 77.4 0.4 1.1e-21 76.6 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EFA86071.1 - 6.5e-22 77.8 0.8 1.2e-21 77.0 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUF4640 PF15480.6 EFA86071.1 - 0.031 14.0 2.8 0.042 13.6 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) FNIP PF05725.12 EFA86072.1 - 2.1e-30 104.6 36.4 7e-07 29.3 0.1 8.5 5 2 4 10 10 10 8 FNIP Repeat F-box PF00646.33 EFA86072.1 - 0.0046 16.8 0.1 0.019 14.9 0.1 2.1 1 0 0 1 1 1 1 F-box domain EF-hand_13 PF17958.1 EFA86072.1 - 0.091 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain FNIP PF05725.12 EFA86073.1 - 1.5e-27 95.5 29.2 6.3e-08 32.7 0.8 7.4 6 1 2 8 8 8 6 FNIP Repeat F-box PF00646.33 EFA86073.1 - 0.0029 17.5 0.1 0.01 15.7 0.1 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA86073.1 - 0.064 13.2 0.1 0.26 11.2 0.1 2.0 1 0 0 1 1 1 0 F-box-like FNIP PF05725.12 EFA86074.1 - 3.9e-11 42.9 24.4 7.3e-05 22.9 0.1 7.0 8 1 0 8 8 8 4 FNIP Repeat RhoGAP PF00620.27 EFA86076.1 - 1.7e-36 125.3 0.1 3.6e-36 124.3 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain AIG1 PF04548.16 EFA86077.1 - 1.8e-11 43.8 0.8 2.2e-11 43.5 0.0 1.6 2 0 0 2 2 1 1 AIG1 family zf-RING_2 PF13639.6 EFA86077.1 - 8e-10 38.9 1.9 2e-09 37.6 1.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFA86077.1 - 1e-08 35.3 2.8 1e-08 35.3 2.8 1.8 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFA86077.1 - 5.9e-08 32.4 1.8 5.9e-08 32.4 1.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFA86077.1 - 3.5e-07 30.0 2.1 8.4e-07 28.8 2.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA86077.1 - 2.3e-06 27.3 0.6 5.1e-06 26.2 0.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 MMR_HSR1 PF01926.23 EFA86077.1 - 4.2e-06 26.8 0.0 8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-RING_5 PF14634.6 EFA86077.1 - 2e-05 24.4 0.9 3.9e-05 23.5 0.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFA86077.1 - 5.5e-05 22.9 0.4 0.00011 22.0 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFA86077.1 - 6.7e-05 22.5 0.7 6.7e-05 22.5 0.7 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EFA86077.1 - 0.0007 19.6 1.8 0.00087 19.3 0.4 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFA86077.1 - 0.0011 19.0 4.6 0.0014 18.6 2.1 2.3 1 1 1 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EFA86077.1 - 0.0045 16.6 0.6 0.0093 15.6 0.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type IIGP PF05049.13 EFA86077.1 - 0.0067 15.5 0.3 0.023 13.8 0.3 1.7 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 EFA86077.1 - 0.03 14.2 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Roc PF08477.13 EFA86077.1 - 0.055 13.7 0.1 0.29 11.4 0.1 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RINGv PF12906.7 EFA86077.1 - 0.079 13.1 1.0 0.19 11.9 1.0 1.7 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EFA86077.1 - 0.081 12.7 0.8 0.18 11.6 0.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Dynamin_N PF00350.23 EFA86077.1 - 0.17 11.9 0.4 0.17 11.9 0.4 2.3 3 0 0 3 3 3 0 Dynamin family FNIP PF05725.12 EFA86078.1 - 1.2e-12 47.7 41.4 9.6e-07 28.9 0.1 8.0 6 3 1 8 8 8 5 FNIP Repeat F-box_5 PF18511.1 EFA86078.1 - 0.00011 21.7 0.2 0.00022 20.7 0.2 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFA86078.1 - 0.057 13.3 0.7 1.5 8.8 0.1 3.0 3 0 0 3 3 3 0 F-box-like PH PF00169.29 EFA86079.1 - 3.1e-29 101.6 0.2 2.8e-14 53.5 0.0 2.9 2 0 0 2 2 2 2 PH domain TPR_19 PF14559.6 EFA86079.1 - 4.3e-13 49.6 0.3 3.6e-08 33.8 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86079.1 - 8.5e-12 44.2 3.0 0.014 15.5 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86079.1 - 3.4e-11 42.5 6.3 0.00099 18.8 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat C2 PF00168.30 EFA86079.1 - 1.1e-08 35.2 0.7 4.2e-07 30.2 1.0 2.8 2 1 0 2 2 1 1 C2 domain TPR_11 PF13414.6 EFA86079.1 - 5.7e-07 29.1 0.2 0.001 18.7 0.1 3.5 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 EFA86079.1 - 1.6e-06 27.9 1.3 1.5 9.2 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86079.1 - 6.6e-06 26.5 0.0 0.12 13.3 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA86079.1 - 1.3e-05 25.4 2.1 8.8e-05 22.7 0.2 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 PH_8 PF15409.6 EFA86079.1 - 2.1e-05 24.7 0.1 0.34 11.2 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 EFA86079.1 - 2.9e-05 24.1 0.3 0.0016 18.6 0.3 2.8 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 EFA86079.1 - 0.00028 21.1 0.0 0.0037 17.5 0.0 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain TPR_20 PF14561.6 EFA86079.1 - 0.00029 21.1 0.1 0.0012 19.1 0.1 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat PH_13 PF16652.5 EFA86079.1 - 0.0015 18.4 0.0 3 7.7 0.0 3.0 2 0 0 2 2 2 2 Pleckstrin homology domain TPR_12 PF13424.6 EFA86079.1 - 0.003 17.8 3.1 9.5 6.6 0.3 3.9 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFA86079.1 - 0.0036 17.6 13.1 0.012 15.9 0.1 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFA86079.1 - 0.0047 17.5 2.8 2.3 9.0 0.0 4.2 5 0 0 5 5 3 1 Tetratricopeptide repeat PH_9 PF15410.6 EFA86079.1 - 0.0055 17.1 0.2 4.9 7.6 0.0 3.4 2 1 0 2 2 2 1 Pleckstrin homology domain TPR_16 PF13432.6 EFA86079.1 - 0.01 16.5 0.1 0.04 14.6 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat PH_11 PF15413.6 EFA86079.1 - 0.45 11.0 14.4 1.4 9.4 1.3 4.5 3 2 0 3 3 3 0 Pleckstrin homology domain MAS20 PF02064.15 EFA86079.1 - 0.99 9.5 6.0 5.8 7.0 0.1 3.2 3 0 0 3 3 3 0 MAS20 protein import receptor Spore_II_R PF09551.10 EFA86079.1 - 4.7 7.7 7.4 1.4 9.4 0.3 3.1 2 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) Ribosomal_S7 PF00177.21 EFA86080.1 - 3.3e-34 117.7 0.9 4.3e-34 117.3 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e YusW PF14039.6 EFA86082.1 - 8.6e-05 23.0 0.7 1.4 9.5 0.1 3.5 2 1 1 3 3 3 2 YusW-like protein F-box-like PF12937.7 EFA86082.1 - 0.057 13.3 0.5 0.14 12.1 0.5 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFA86082.1 - 0.067 13.1 1.0 0.21 11.5 0.1 2.3 2 0 0 2 2 2 0 F-box domain KASH PF10541.9 EFA86083.1 - 0.0091 16.2 1.1 0.0094 16.2 1.1 1.1 1 0 0 1 1 1 1 Nuclear envelope localisation domain KASH PF10541.9 EFA86084.1 - 0.15 12.4 1.1 0.19 12.0 1.1 1.1 1 0 0 1 1 1 0 Nuclear envelope localisation domain F-box-like PF12937.7 EFA86085.1 - 0.042 13.7 0.3 0.1 12.5 0.3 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFA86085.1 - 0.06 13.2 0.8 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 F-box domain Kelch_6 PF13964.6 EFA86089.1 - 1.4e-19 69.6 1.4 1.4e-08 34.7 0.0 5.2 4 2 1 5 5 5 2 Kelch motif zf-B_box PF00643.24 EFA86089.1 - 0.0025 18.0 12.6 0.0059 16.7 12.6 1.6 1 0 0 1 1 1 1 B-box zinc finger DUF1461 PF07314.11 EFA86089.1 - 0.025 14.5 1.7 0.025 14.5 1.7 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1461) Kelch_4 PF13418.6 EFA86089.1 - 0.044 13.8 0.9 2.1 8.4 0.0 4.0 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_3 PF13415.6 EFA86089.1 - 0.12 12.7 0.1 1.8 9.0 0.0 3.2 2 1 1 3 3 3 0 Galactose oxidase, central domain PilJ PF13675.6 EFA86089.1 - 0.51 10.4 3.2 0.56 10.2 0.4 2.4 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Kelch_5 PF13854.6 EFA86089.1 - 1.9 8.6 6.0 5.6 7.1 0.3 3.3 3 0 0 3 3 3 0 Kelch motif RRM_1 PF00076.22 EFA86091.1 - 1.3e-50 169.0 14.8 6.8e-15 54.7 0.7 5.6 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA86091.1 - 3.2e-09 36.8 1.2 0.052 13.7 0.0 4.9 4 0 0 4 4 4 3 RNA recognition motif DbpA PF03880.15 EFA86091.1 - 0.0011 18.9 2.0 0.26 11.3 0.2 3.9 4 0 0 4 4 4 1 DbpA RNA binding domain BUD22 PF09073.10 EFA86091.1 - 0.0049 16.3 41.0 0.0049 16.3 41.0 3.6 4 0 0 4 4 4 1 BUD22 Limkain-b1 PF11608.8 EFA86091.1 - 0.016 15.3 4.1 0.77 9.9 0.0 4.0 4 0 0 4 4 4 0 Limkain b1 Pkinase PF00069.25 EFA86092.1 - 6.1e-70 235.6 0.0 6.1e-70 235.6 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86092.1 - 4.1e-47 160.6 0.0 9.9e-47 159.4 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA86092.1 - 9.8e-08 31.2 0.0 9.8e-08 31.2 0.0 2.7 2 1 1 3 3 3 1 Fungal protein kinase Kdo PF06293.14 EFA86092.1 - 0.024 14.0 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4337 PF14235.6 EFA86092.1 - 0.48 10.5 15.0 1 9.5 1.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Med27 PF11571.8 EFA86094.1 - 6.1e-21 74.6 0.0 6.1e-21 74.6 0.0 4.4 4 0 0 4 4 4 1 Mediator complex subunit 27 Kelch_6 PF13964.6 EFA86094.1 - 2.7e-14 52.8 5.5 4.5e-05 23.6 0.1 5.2 5 0 0 5 5 5 3 Kelch motif zf-B_box PF00643.24 EFA86094.1 - 0.00073 19.6 13.2 0.0026 17.9 13.2 1.9 1 0 0 1 1 1 1 B-box zinc finger Kelch_4 PF13418.6 EFA86094.1 - 0.0041 17.1 1.6 3.5 7.7 0.0 3.7 2 1 0 2 2 2 2 Galactose oxidase, central domain GCR1_C PF12550.8 EFA86094.1 - 0.1 12.9 0.6 0.97 9.8 0.3 2.8 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Kelch_5 PF13854.6 EFA86094.1 - 0.13 12.3 9.2 0.13 12.2 0.5 3.5 3 0 0 3 3 3 0 Kelch motif Dicty_CTDC PF00526.18 EFA86095.1 - 1.7e-34 117.3 144.8 7.3e-10 38.6 11.9 10.2 10 2 0 10 10 10 7 Dictyostelium (slime mold) repeat PI3_PI4_kinase PF00454.27 EFA86096.1 - 1.7e-60 204.9 0.8 1.2e-59 202.2 0.2 2.5 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFA86096.1 - 2.7e-53 180.1 0.1 6.1e-53 179.0 0.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_rbd PF00794.18 EFA86096.1 - 1.6e-23 82.9 5.2 1.8e-23 82.8 0.1 3.1 3 0 0 3 3 3 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EFA86096.1 - 4.3e-21 75.3 0.0 1.3e-20 73.7 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Ank_2 PF12796.7 EFA86099.1 - 1.3e-18 67.4 0.5 2.5e-06 28.0 0.1 3.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86099.1 - 1.4e-16 60.6 1.0 2.9e-06 27.7 0.0 6.3 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86099.1 - 1.7e-08 34.0 0.1 0.38 11.5 0.1 6.6 6 1 1 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EFA86099.1 - 2.5e-08 34.0 0.1 0.011 16.1 0.1 5.4 3 2 3 6 6 6 2 Ankyrin repeats (many copies) Ank PF00023.30 EFA86099.1 - 0.00022 21.6 0.3 5.4 7.6 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeat UQ_con PF00179.26 EFA86100.1 - 5.2e-48 162.3 0.0 5.9e-48 162.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EFA86100.1 - 4.3e-05 23.4 0.0 6.4e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EFA86100.1 - 0.0046 17.2 0.1 0.0079 16.5 0.1 1.5 1 1 0 1 1 1 1 RWD domain FNIP PF05725.12 EFA86101.1 - 0.00074 19.6 3.9 0.00074 19.6 3.9 2.4 2 1 0 2 2 2 1 FNIP Repeat FNIP PF05725.12 EFA86102.1 - 3.7e-09 36.6 27.4 0.012 15.7 1.5 7.4 6 2 1 7 7 7 5 FNIP Repeat F-box-like PF12937.7 EFA86102.1 - 0.00067 19.5 0.5 0.0019 18.0 0.5 1.9 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFA86102.1 - 0.02 14.5 0.1 0.046 13.3 0.1 1.6 1 0 0 1 1 1 0 F-box TIG PF01833.24 EFA86104.1 - 3.7e-06 26.9 26.7 2.2e-05 24.4 0.3 6.1 6 1 0 6 6 6 3 IPT/TIG domain Lectin_C PF00059.21 EFA86104.1 - 0.0016 19.2 1.0 0.0026 18.5 0.2 1.8 2 0 0 2 2 2 1 Lectin C-type domain EGF_Tenascin PF18720.1 EFA86104.1 - 0.033 14.3 8.3 0.079 13.0 8.3 1.7 1 0 0 1 1 1 0 Tenascin EGF domain EB PF01683.18 EFA86104.1 - 0.14 12.5 6.6 0.34 11.2 6.6 1.6 1 0 0 1 1 1 0 EB module EGF_2 PF07974.13 EFA86104.1 - 0.19 12.2 16.3 0.39 11.1 16.3 1.5 1 0 0 1 1 1 0 EGF-like domain SIS PF01380.22 EFA86105.1 - 0.034 14.0 0.0 0.04 13.8 0.0 1.0 1 0 0 1 1 1 0 SIS domain UME PF08064.13 EFA86105.1 - 0.038 13.9 0.1 0.07 13.1 0.1 1.5 1 1 1 2 2 2 0 UME (NUC010) domain Sugar_tr PF00083.24 EFA86109.1 - 8.3e-41 140.3 25.2 3.2e-39 135.1 25.2 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFA86109.1 - 1.1e-36 126.5 40.7 2.7e-30 105.5 26.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily RabGAP-TBC PF00566.18 EFA86111.1 - 1.7e-44 152.0 4.8 1.7e-44 152.0 4.8 3.4 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 EFA86111.1 - 2.1e-18 66.7 2.3 1.6e-13 51.1 0.6 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86111.1 - 2.7e-15 56.5 0.6 5.8e-06 26.7 0.2 4.1 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFA86111.1 - 2e-10 40.6 3.9 0.15 12.5 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EFA86111.1 - 7.2e-10 38.3 3.4 0.27 11.9 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFA86111.1 - 7e-07 29.4 3.4 0.23 11.9 0.5 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ras PF00071.22 EFA86112.1 - 2.3e-40 137.9 0.0 2.6e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86112.1 - 2.5e-16 60.0 0.0 3.5e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA86112.1 - 0.013 15.0 0.0 0.02 14.3 0.0 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFA86112.1 - 0.021 14.7 0.0 1.1 9.2 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EFA86112.1 - 0.023 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EFA86112.1 - 0.072 13.5 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFA86112.1 - 0.14 11.9 0.1 0.28 10.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain L-fibroin PF05849.11 EFA86112.1 - 0.15 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) Ank_2 PF12796.7 EFA86113.1 - 0.00074 20.0 0.1 0.016 15.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_2 PF12796.7 EFA86114.1 - 0.00054 20.5 1.4 0.013 16.1 0.0 3.4 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) CDC45 PF02724.14 EFA86115.1 - 0.13 10.5 12.2 0.22 9.8 12.2 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EFA86115.1 - 0.16 11.4 15.7 0.24 10.8 15.7 1.2 1 0 0 1 1 1 0 SDA1 Ank_2 PF12796.7 EFA86115.1 - 0.23 12.1 1.1 0.76 10.4 0.5 2.2 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Nop14 PF04147.12 EFA86115.1 - 0.24 9.6 17.9 0.36 9.0 17.9 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 EFA86115.1 - 0.3 11.4 11.2 0.57 10.5 11.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3447 PF11929.8 EFA86115.1 - 0.64 10.0 8.1 2.4 8.2 1.8 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3447) DNA_pol_phi PF04931.13 EFA86115.1 - 2 6.4 19.2 3.7 5.5 19.2 1.4 1 0 0 1 1 1 0 DNA polymerase phi CPSF100_C PF13299.6 EFA86115.1 - 3.2 7.9 8.5 7.5 6.7 8.5 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ank_2 PF12796.7 EFA86116.1 - 3.7e-05 24.2 0.4 0.049 14.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) ENTH PF01417.20 EFA86116.1 - 0.019 15.0 0.6 0.073 13.1 0.4 2.2 1 1 0 1 1 1 0 ENTH domain Ank_2 PF12796.7 EFA86117.1 - 2.4e-10 40.8 0.2 0.00091 19.8 0.0 4.3 4 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86117.1 - 0.02 15.5 0.0 26 5.6 0.0 4.5 5 0 0 5 5 5 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86117.1 - 0.25 12.0 0.9 13 6.8 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeat DUF3447 PF11929.8 EFA86117.1 - 2.8 8.0 16.2 0.14 12.1 0.4 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA86118.1 - 0.00013 22.5 0.3 0.017 15.7 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) RasGEF_N PF00618.20 EFA86118.1 - 0.22 11.8 2.7 0.24 11.7 0.4 2.2 2 0 0 2 2 2 0 RasGEF N-terminal motif Zip PF02535.22 EFA86119.1 - 0.26 10.5 0.9 0.38 9.9 0.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SDA1 PF05285.12 EFA86119.1 - 0.5 9.7 17.9 0.75 9.2 17.9 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFA86119.1 - 0.56 8.4 11.9 0.84 7.8 11.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFA86119.1 - 0.72 8.0 18.5 1 7.5 18.5 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 EFA86119.1 - 2.9 6.6 7.8 4.3 6.0 7.8 1.1 1 0 0 1 1 1 0 Presenilin PH PF00169.29 EFA86120.1 - 0.00018 22.0 0.3 0.00083 19.8 0.0 2.3 2 0 0 2 2 2 1 PH domain PI3_PI4_kinase PF00454.27 EFA86121.1 - 2.2e-52 178.3 2.0 5.3e-52 177.1 0.0 2.6 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase SMG1 PF15785.5 EFA86121.1 - 5.4e-31 107.7 6.9 5.4e-31 107.7 6.9 3.8 2 1 0 2 2 2 1 Serine/threonine-protein kinase smg-1 FATC PF02260.20 EFA86121.1 - 4.4e-11 42.4 0.1 3.9e-10 39.4 0.0 2.5 2 0 0 2 2 2 1 FATC domain RLL PF10036.9 EFA86122.1 - 1.5e-66 224.9 6.5 1.9e-66 224.5 6.5 1.2 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein DUF3439 PF11921.8 EFA86122.1 - 0.24 11.4 11.4 0.46 10.5 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EFA86122.1 - 4.8 7.2 18.5 7.5 6.5 18.5 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Nucleic_acid_bd PF13820.6 EFA86123.1 - 0.07 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Putative nucleic acid-binding region TPP_enzyme_N PF02776.18 EFA86124.1 - 8e-41 139.5 0.4 1.1e-39 135.8 0.1 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFA86124.1 - 9.3e-32 109.6 0.0 1.5e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EFA86124.1 - 4.3e-20 72.0 0.0 3.7e-19 69.0 0.0 2.4 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ank_2 PF12796.7 EFA86125.1 - 2.5e-16 60.0 2.3 0.0025 18.3 0.2 5.8 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86125.1 - 9.9e-15 54.7 0.1 1.4 9.6 0.0 8.3 7 2 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86125.1 - 9.8e-09 34.8 2.6 51 4.9 0.0 9.4 11 0 0 11 11 11 0 Ankyrin repeat Ank_5 PF13857.6 EFA86125.1 - 2.3e-07 30.9 4.9 1.3 9.5 0.1 8.0 7 3 4 11 11 11 2 Ankyrin repeats (many copies) DUF4519 PF15012.6 EFA86125.1 - 0.36 11.0 1.2 0.86 9.8 1.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Dimer_Tnp_hAT PF05699.14 EFA86126.1 - 6.4e-14 51.5 0.4 1.8e-13 50.1 0.2 1.8 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Calycin_like PF13944.6 EFA86126.1 - 0.019 15.3 0.3 0.028 14.7 0.3 1.3 1 0 0 1 1 1 0 Calycin-like beta-barrel domain FOXP-CC PF16159.5 EFA86128.1 - 0.00041 20.9 25.8 0.08 13.6 1.9 5.6 3 2 3 6 6 6 3 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EFA86128.1 - 0.00046 20.1 3.6 0.3 11.1 0.3 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EFA86128.1 - 0.00059 20.1 3.9 0.023 15.0 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 EFA86128.1 - 0.0049 17.2 0.7 0.0049 17.2 0.7 4.5 6 0 0 6 6 6 1 Zinc-finger double domain zf-C2H2_3rep PF18868.1 EFA86128.1 - 1 10.1 14.9 6.8 7.4 2.0 3.8 1 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 EFA86128.1 - 2.3 8.8 25.8 0.44 11.1 0.6 5.2 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFA86128.1 - 3.7 8.7 26.4 1.1 10.2 0.5 5.4 5 0 0 5 5 5 0 C2H2-type zinc finger E1_dh PF00676.20 EFA86129.1 - 1.5e-102 342.6 0.1 2.3e-102 342.0 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Oxysterol_BP PF01237.18 EFA86129.1 - 2.5e-63 214.2 14.1 1.2e-57 195.5 3.4 2.2 1 1 1 2 2 2 2 Oxysterol-binding protein GramPos_pilinD3 PF16570.5 EFA86129.1 - 0.002 18.9 0.5 0.0051 17.5 0.5 1.6 1 0 0 1 1 1 1 Gram-positive pilin backbone subunit 3, Cna-B-like domain DUF1479 PF07350.12 EFA86131.1 - 1e-10 41.0 1.9 8.1e-07 28.1 0.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1479) NERD PF08378.11 EFA86131.1 - 0.074 13.5 0.5 0.52 10.8 0.0 2.4 2 0 0 2 2 2 0 Nuclease-related domain BRO1 PF03097.18 EFA86132.1 - 0.00085 18.2 0.3 0.00091 18.1 0.3 1.1 1 0 0 1 1 1 1 BRO1-like domain DUF2151 PF10221.9 EFA86132.1 - 0.036 12.7 1.9 0.035 12.7 1.9 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator APG6_N PF17675.1 EFA86132.1 - 0.049 14.2 12.8 0.065 13.8 12.8 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region HEPN_AbiU2 PF18734.1 EFA86132.1 - 0.17 11.4 6.7 0.2 11.1 6.7 1.1 1 0 0 1 1 1 0 AbiU2 DUF4337 PF14235.6 EFA86132.1 - 0.52 10.4 5.1 0.65 10.1 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) KfrA_N PF11740.8 EFA86132.1 - 0.74 10.5 6.6 1 10.0 6.6 1.3 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DUF4140 PF13600.6 EFA86132.1 - 0.84 10.1 6.8 1.3 9.5 6.8 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF874 PF05917.11 EFA86132.1 - 1.5 7.7 6.2 1.8 7.5 6.2 1.0 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Merozoite_SPAM PF07133.11 EFA86132.1 - 2.9 7.8 20.1 3.3 7.7 20.1 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF2951 PF11166.8 EFA86132.1 - 4.2 7.7 9.5 5.6 7.3 8.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) V_ATPase_I PF01496.19 EFA86132.1 - 4.7 5.0 5.2 5.1 4.9 5.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FNIP PF05725.12 EFA86133.1 - 4.6e-70 231.6 27.9 7.7e-16 58.0 2.8 10.3 3 3 3 9 9 9 9 FNIP Repeat Pkinase PF00069.25 EFA86133.1 - 9.8e-16 57.9 3.6 7e-14 51.8 0.1 2.7 2 0 0 2 2 2 2 Protein kinase domain DUF1769 PF08588.10 EFA86133.1 - 6e-05 23.2 4.0 3.7 7.8 0.0 6.4 7 1 1 8 8 8 2 Protein of unknown function (DUF1769) Pkinase_Tyr PF07714.17 EFA86133.1 - 0.00066 19.0 0.0 0.0014 18.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA86133.1 - 0.0047 16.3 0.1 0.079 12.3 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Mvb12 PF09452.10 EFA86133.1 - 0.011 16.1 0.2 0.045 14.2 0.2 2.0 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 APH PF01636.23 EFA86133.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-B_box PF00643.24 EFA86134.1 - 0.0099 16.0 13.4 0.024 14.8 13.4 1.6 1 0 0 1 1 1 1 B-box zinc finger Mce4_CUP1 PF11887.8 EFA86134.1 - 0.015 14.8 3.7 2.8 7.3 0.4 3.1 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative CD52 PF15116.6 EFA86135.1 - 0.57 10.3 6.2 0.88 9.6 6.2 1.3 1 0 0 1 1 1 0 CAMPATH-1 antigen Endotoxin_N PF03945.14 EFA86136.1 - 7.9e-05 22.5 0.5 0.00032 20.5 0.0 2.1 2 0 0 2 2 2 1 delta endotoxin, N-terminal domain DUF1016_N PF17761.1 EFA86136.1 - 0.07 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 DUF1016 N-terminal domain FliC_SP PF12613.8 EFA86137.1 - 0.073 13.6 1.5 0.11 13.0 0.4 1.8 2 0 0 2 2 2 0 Flagellin structural protein Chlam_PMP PF02415.17 EFA86138.1 - 0.021 15.3 12.8 0.1 13.1 0.1 3.3 3 0 0 3 3 3 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat NOA36 PF06524.12 EFA86139.1 - 3.3 6.9 14.4 4.4 6.5 14.3 1.3 1 1 0 1 1 1 0 NOA36 protein Endotoxin_N PF03945.14 EFA86140.1 - 0.00016 21.5 0.7 0.00072 19.3 0.0 2.2 2 1 0 2 2 2 1 delta endotoxin, N-terminal domain DUF1016_N PF17761.1 EFA86140.1 - 0.008 16.3 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 DUF1016 N-terminal domain Ras PF00071.22 EFA86141.1 - 2e-37 128.3 0.0 2.2e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86141.1 - 2.7e-18 66.3 0.0 3.8e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA86141.1 - 2.5e-05 23.8 0.0 4.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SNF2_N PF00176.23 EFA86141.1 - 0.033 12.9 0.0 0.043 12.5 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain TniB PF05621.11 EFA86141.1 - 0.12 11.8 0.0 1.2 8.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein MMR_HSR1 PF01926.23 EFA86141.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EFA86141.1 - 0.17 11.4 0.2 3.3 7.2 0.0 2.6 3 0 0 3 3 3 0 P-loop containing dynein motor region Dicty_REP PF05086.12 EFA86142.1 - 0.00014 20.0 6.3 0.00014 20.0 6.3 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Tir_receptor_C PF07489.11 EFA86142.1 - 0.018 15.0 11.9 0.024 14.6 11.9 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF4724 PF15852.5 EFA86142.1 - 0.34 11.4 4.8 0.51 10.9 4.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4724) Dynactin PF12455.8 EFA86144.1 - 3e-37 128.4 12.5 3e-37 128.4 12.5 5.8 4 2 2 6 6 6 1 Dynein associated protein CAP_GLY PF01302.25 EFA86144.1 - 1.9e-22 79.0 2.1 3.3e-22 78.3 2.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain CSN4_RPN5_eIF3a PF18420.1 EFA86144.1 - 1.2 9.3 3.9 19 5.6 0.1 3.3 3 0 0 3 3 3 0 CSN4/RPN5/eIF3a helix turn helix domain RL10P_insert PF17777.1 EFA86145.1 - 1e-19 70.3 0.5 2.5e-19 69.0 0.5 1.7 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EFA86145.1 - 3.2e-17 62.9 5.8 7.6e-17 61.7 5.8 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L10 PF00466.20 EFA86145.1 - 4.9e-17 61.9 0.7 9.4e-17 61.0 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 ATG_C PF09333.11 EFA86145.1 - 0.028 14.8 0.6 0.078 13.3 0.6 1.7 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain Amidohydro_2 PF04909.14 EFA86146.1 - 6.4e-59 200.1 0.0 7.3e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase PhoLip_ATPase_C PF16212.5 EFA86147.1 - 1.9e-89 299.7 27.7 1.9e-89 299.7 27.7 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFA86147.1 - 1.6e-27 95.0 5.0 5.3e-27 93.3 5.0 2.0 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFA86147.1 - 2.9e-12 46.5 0.0 8.6e-11 41.8 0.0 3.0 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFA86147.1 - 1.2e-11 44.5 0.0 1.2e-11 44.5 0.0 2.5 3 1 1 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EFA86147.1 - 3.3e-09 37.3 0.4 8.4e-05 22.9 0.1 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFA86147.1 - 0.0059 16.4 0.1 0.0059 16.4 0.1 2.8 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Methylase_S PF01420.19 EFA86147.1 - 0.019 15.2 3.0 5.3 7.2 0.0 3.0 3 0 0 3 3 3 0 Type I restriction modification DNA specificity domain Alpha_L_fucos PF01120.17 EFA86148.1 - 1.6e-113 379.7 3.8 2e-113 379.4 3.8 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EFA86148.1 - 1e-22 80.5 0.2 3.1e-22 78.9 0.0 2.0 2 0 0 2 2 2 1 Alpha-L-fucosidase C-terminal domain SWIB PF02201.18 EFA86149.1 - 7.1e-11 41.8 0.7 1.4e-10 40.9 0.7 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain DOT1 PF08123.13 EFA86149.1 - 0.0039 16.8 0.7 0.0098 15.4 0.0 1.8 2 0 0 2 2 2 1 Histone methylation protein DOT1 EF-hand_9 PF14658.6 EFA86150.1 - 0.017 15.4 0.0 3.1 8.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_6 PF13405.6 EFA86150.1 - 0.075 13.0 0.0 0.22 11.6 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain Rootletin PF15035.6 EFA86150.1 - 0.37 10.8 21.5 0.059 13.4 4.5 2.8 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Ricin_B_lectin PF00652.22 EFA86152.1 - 1.5e-06 28.5 0.1 9.6e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain RHS PF03527.14 EFA86152.1 - 0.013 15.3 0.0 9 6.1 0.0 2.9 2 0 0 2 2 2 0 RHS protein adh_short PF00106.25 EFA86153.1 - 4.2e-18 65.5 0.0 1.1e-10 41.4 0.0 2.9 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86153.1 - 2.4e-11 43.6 0.0 0.00014 21.5 0.2 3.0 3 1 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFA86153.1 - 0.056 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RCC1 PF00415.18 EFA86155.1 - 4.1e-75 248.2 5.3 2.8e-15 56.7 0.4 7.2 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA86155.1 - 1.8e-34 116.8 25.5 8.3e-09 35.0 0.5 7.4 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat FNIP PF05725.12 EFA86156.1 - 1.1e-81 268.7 44.9 1.4e-15 57.2 0.2 8.8 4 2 4 9 9 9 8 FNIP Repeat Pkinase PF00069.25 EFA86156.1 - 3e-27 95.6 5.1 7.2e-27 94.4 5.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86156.1 - 8e-13 48.3 0.5 2.9e-08 33.3 0.6 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Rcd1 PF04078.13 EFA86156.1 - 0.011 15.1 0.1 2.2 7.5 0.0 3.3 2 1 3 5 5 5 0 Cell differentiation family, Rcd1-like DUF445 PF04286.12 EFA86156.1 - 0.016 15.0 4.4 0.17 11.7 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF445) PhaP_Bmeg PF09602.10 EFA86156.1 - 0.13 12.2 3.9 0.16 11.9 0.1 2.9 4 0 0 4 4 4 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF3837 PF12939.7 EFA86156.1 - 1.5 9.2 3.6 5.1 7.6 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3837) RYDR_ITPR PF01365.21 EFA86157.1 - 2e-22 79.6 15.7 1.5e-15 57.2 1.9 5.4 4 1 0 4 4 4 2 RIH domain RIH_assoc PF08454.11 EFA86157.1 - 1.6e-19 69.6 4.8 1.6e-19 69.6 4.8 4.3 3 1 0 3 3 3 1 RyR and IP3R Homology associated Ins145_P3_rec PF08709.11 EFA86157.1 - 2.9e-08 33.2 0.0 9e-08 31.6 0.0 1.9 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor Herpes_BLRF2 PF05812.12 EFA86157.1 - 0.00036 20.7 0.0 0.0012 19.0 0.0 1.9 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein FNIP PF05725.12 EFA86158.1 - 4.1e-65 215.7 33.4 2.4e-14 53.2 3.1 9.3 4 2 4 9 9 9 9 FNIP Repeat Pkinase PF00069.25 EFA86158.1 - 4e-23 82.1 13.0 1.1e-18 67.6 3.3 3.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86158.1 - 9.7e-14 51.3 3.8 1.4e-08 34.4 0.6 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase APH PF01636.23 EFA86158.1 - 0.18 11.7 0.2 0.39 10.6 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family LPD34 PF18852.1 EFA86159.1 - 0.027 14.1 0.5 5.4 6.5 0.0 2.9 3 0 0 3 3 3 0 Large polyvalent protein associated domain 34 Atg8 PF02991.16 EFA86159.1 - 0.17 12.1 1.3 4.4 7.5 0.1 2.8 1 1 2 3 3 3 0 Autophagy protein Atg8 ubiquitin like Pkinase PF00069.25 EFA86160.1 - 3.1e-05 23.5 0.2 0.00011 21.7 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 EFA86160.1 - 0.00042 20.3 0.1 0.00068 19.6 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFA86160.1 - 0.0013 17.6 0.0 0.0031 16.4 0.2 1.5 2 0 0 2 2 2 1 Fungal protein kinase ATPase PF06745.13 EFA86161.1 - 0.024 14.0 0.1 0.078 12.3 0.0 1.8 2 0 0 2 2 2 0 KaiC FNIP PF05725.12 EFA86162.1 - 2.3e-27 94.9 29.5 2e-06 27.9 0.2 8.3 4 3 3 8 8 8 8 FNIP Repeat FNIP PF05725.12 EFA86163.1 - 6.1e-69 228.0 44.7 5.1e-13 49.0 0.5 10.5 7 2 2 10 10 10 9 FNIP Repeat Pkinase PF00069.25 EFA86163.1 - 6e-22 78.3 11.1 4.2e-11 42.7 0.3 3.9 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86163.1 - 1.7e-09 37.3 1.8 4.1e-05 23.0 0.1 4.0 4 0 0 4 4 4 3 Protein tyrosine kinase DUF1769 PF08588.10 EFA86163.1 - 0.015 15.5 12.7 10 6.4 0.1 7.7 6 3 4 10 10 10 0 Protein of unknown function (DUF1769) DUF1168 PF06658.12 EFA86164.1 - 0.032 14.0 1.8 0.042 13.7 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Aa_trans PF01490.18 EFA86165.1 - 4.3e-12 45.4 32.9 2.3e-07 29.9 3.7 2.4 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein Herpes_UL49_5 PF05702.11 EFA86165.1 - 0.036 14.1 1.1 0.15 12.2 1.1 2.0 1 0 0 1 1 1 0 Herpesvirus UL49.5 envelope/tegument protein ACOX PF01756.19 EFA86166.1 - 4e-05 23.3 0.9 8.3e-05 22.2 0.9 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Snf7 PF03357.21 EFA86167.1 - 1.1e-39 135.8 31.5 1.3e-39 135.5 31.5 1.0 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 EFA86167.1 - 0.0017 18.3 9.8 0.0023 17.9 9.8 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Hemagglutinin PF00509.18 EFA86167.1 - 0.45 8.8 8.5 0.038 12.4 2.5 1.8 2 0 0 2 2 2 0 Haemagglutinin AMP-binding_C_2 PF14535.6 EFA86167.1 - 0.84 10.0 6.0 0.2 12.0 1.5 2.1 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain TIM PF00121.18 EFA86168.1 - 4.9e-86 288.0 0.1 5.6e-86 287.9 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CutC PF03932.14 EFA86168.1 - 0.033 13.7 0.0 0.23 10.9 0.0 2.0 1 1 1 2 2 2 0 CutC family adh_short PF00106.25 EFA86169.1 - 1.6e-19 70.1 0.1 6.3e-11 42.1 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86169.1 - 3.9e-11 43.0 0.0 0.00042 19.9 0.0 2.8 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase DUF3430 PF11912.8 EFA86170.1 - 2.8e-26 92.9 24.0 3.2e-26 92.7 24.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) SpoU_methylase PF00588.19 EFA86171.1 - 6.5e-25 87.9 0.0 1.4e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EFA86171.1 - 4.2e-06 26.9 0.0 1.2e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Pkinase PF00069.25 EFA86172.1 - 2.3e-56 191.1 0.7 1e-55 189.0 0.4 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86172.1 - 1.3e-39 136.1 0.2 2.9e-39 134.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase DUF3543 PF12063.8 EFA86172.1 - 1.8e-10 40.7 2.9 1.8e-10 40.7 2.9 3.1 1 1 1 2 2 1 1 Domain of unknown function (DUF3543) Velvet PF11754.8 EFA86172.1 - 0.00032 20.7 2.7 0.00042 20.3 2.7 1.2 1 0 0 1 1 1 1 Velvet factor TFIIA PF03153.13 EFA86172.1 - 0.0022 18.1 14.8 0.0031 17.6 14.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MIT PF04212.18 EFA86172.1 - 0.0027 17.7 1.9 0.018 15.1 0.2 2.5 2 1 0 2 2 2 1 MIT (microtubule interacting and transport) domain Pkinase_fungal PF17667.1 EFA86172.1 - 0.0072 15.1 0.0 0.0072 15.1 0.0 2.1 1 1 1 2 2 1 1 Fungal protein kinase DUF4647 PF15504.6 EFA86172.1 - 0.009 15.2 9.9 0.017 14.2 9.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) ABC1 PF03109.16 EFA86172.1 - 0.031 14.4 0.0 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 ABC1 family CSRNP_N PF16019.5 EFA86172.1 - 0.032 14.1 5.0 0.057 13.3 5.0 1.4 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus APH PF01636.23 EFA86172.1 - 0.061 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family UPF0524 PF15823.5 EFA86172.1 - 0.38 10.1 3.1 0.6 9.5 3.1 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 Presenilin PF01080.17 EFA86172.1 - 0.57 8.9 10.4 0.81 8.4 10.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 EFA86172.1 - 4.4 6.6 7.8 6.5 6.0 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPC1_N PF16414.5 EFA86173.1 - 1.9e-12 47.3 1.2 2.2e-12 47.0 1.2 1.1 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Folate_rec PF03024.14 EFA86173.1 - 0.0025 17.7 0.5 0.003 17.4 0.5 1.2 1 0 0 1 1 1 1 Folate receptor family Kelch_6 PF13964.6 EFA86174.1 - 4.9e-10 39.3 3.2 4.7e-08 33.0 0.1 4.7 6 0 0 6 6 6 1 Kelch motif NAD_binding_10 PF13460.6 EFA86174.1 - 1.1e-06 28.6 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFA86174.1 - 5.5e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EFA86174.1 - 0.041 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Kelch_5 PF13854.6 EFA86174.1 - 0.071 13.1 0.3 0.62 10.1 0.3 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 EFA86174.1 - 0.073 12.7 1.7 0.29 10.7 0.2 2.6 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 EFA86175.1 - 5.9e-05 23.2 6.7 0.0016 18.7 0.1 4.6 5 0 0 5 5 5 1 Kelch motif DUF4413 PF14372.6 EFA86175.1 - 0.019 15.3 1.3 5.9 7.3 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) Kelch_5 PF13854.6 EFA86175.1 - 0.051 13.6 1.2 0.77 9.8 0.1 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 EFA86175.1 - 0.071 12.7 1.0 0.52 9.9 0.1 2.5 2 0 0 2 2 2 0 Kelch motif eIF3_p135 PF12807.7 EFA86175.1 - 0.094 12.7 7.3 0.24 11.4 1.1 2.7 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Kelch_4 PF13418.6 EFA86175.1 - 0.12 12.4 0.5 1.7 8.7 0.0 3.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Endotoxin_N PF03945.14 EFA86176.1 - 3.5e-05 23.6 0.0 0.00013 21.7 0.0 1.9 2 0 0 2 2 2 1 delta endotoxin, N-terminal domain DUF1016_N PF17761.1 EFA86176.1 - 0.015 15.5 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 DUF1016 N-terminal domain Ras PF00071.22 EFA86177.1 - 1.9e-38 131.6 0.0 2.2e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86177.1 - 2.5e-18 66.4 0.0 3.6e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA86177.1 - 2e-05 24.1 0.0 3.4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SNF2_N PF00176.23 EFA86177.1 - 0.027 13.2 0.0 0.036 12.8 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain MMR_HSR1 PF01926.23 EFA86177.1 - 0.049 13.7 0.0 0.067 13.3 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Response_reg PF00072.24 EFA86177.1 - 0.06 13.5 0.0 1.6 8.9 0.0 2.2 2 0 0 2 2 2 0 Response regulator receiver domain FleQ PF06490.11 EFA86177.1 - 0.16 12.4 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ TniB PF05621.11 EFA86177.1 - 0.18 11.2 0.0 2 7.8 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein Dicty_CTDC PF00526.18 EFA86178.1 - 4.9e-55 183.0 154.0 3.9e-10 39.4 12.5 11.4 11 0 0 11 11 11 11 Dictyostelium (slime mold) repeat RRM_1 PF00076.22 EFA86181.1 - 1.4e-37 127.3 0.4 2.6e-18 65.6 0.1 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA86181.1 - 0.00038 20.4 0.0 1.4 8.9 0.0 3.4 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif SmAKAP PF15127.6 EFA86181.1 - 0.4 11.9 0.1 0.4 11.9 0.1 4.3 3 1 0 3 3 3 0 Small membrane A-kinase anchor protein PI3Ka PF00613.20 EFA86182.1 - 0.0006 19.3 0.1 0.0006 19.3 0.1 2.1 3 0 0 3 3 3 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA86183.1 - 1.8e-28 100.0 0.1 8.1e-26 91.3 0.1 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 EFA86183.1 - 0.0012 18.2 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Replic_Relax PF13814.6 EFA86183.1 - 0.0029 17.7 0.1 0.01 15.9 0.0 1.8 2 0 0 2 2 2 1 Replication-relaxation DUF1678 PF07913.11 EFA86184.1 - 0.018 14.8 0.0 0.44 10.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1678) Chorein_N PF12624.7 EFA86184.1 - 0.033 14.3 0.3 0.2 11.8 0.1 2.4 2 0 0 2 2 2 0 N-terminal region of Chorein or VPS13 Glyco_hydro_28 PF00295.17 EFA86185.1 - 1.4e-36 126.2 3.8 5.2e-33 114.5 0.4 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 Beta_helix PF13229.6 EFA86185.1 - 8.8e-07 28.9 14.3 2e-06 27.7 5.9 2.8 2 1 0 2 2 2 2 Right handed beta helix region Pkinase PF00069.25 EFA86186.1 - 2.8e-45 154.7 0.0 9.3e-45 153.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86186.1 - 1.8e-44 152.0 0.0 1.2e-29 103.4 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase RhoGEF PF00621.20 EFA86186.1 - 2.5e-27 96.3 13.3 1e-26 94.3 13.3 2.1 1 1 0 1 1 1 1 RhoGEF domain PH PF00169.29 EFA86186.1 - 4.6e-05 23.9 0.1 0.0032 18.0 0.0 3.2 2 1 0 2 2 2 1 PH domain TrmO PF01980.16 EFA86186.1 - 0.0024 18.1 0.2 0.014 15.6 0.2 2.2 1 1 0 1 1 1 1 tRNA-methyltransferase O Pkinase_fungal PF17667.1 EFA86186.1 - 0.0092 14.8 3.5 0.017 13.9 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 EFA86186.1 - 0.04 13.3 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fcf1 PF04900.12 EFA86187.1 - 9.5e-35 119.0 1.8 1.8e-34 118.1 1.8 1.5 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EFA86187.1 - 1.6e-11 44.5 0.0 2.6e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 PIN like domain Peptidase_M20 PF01546.28 EFA86188.1 - 6e-33 114.3 0.0 9e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA86188.1 - 5.6e-09 35.9 0.0 1.3e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain EF-hand_13 PF17958.1 EFA86191.1 - 0.052 13.4 0.2 0.17 11.7 0.1 2.0 1 1 0 1 1 1 0 EF-hand domain FNIP PF05725.12 EFA86191.1 - 0.95 9.7 0.0 0.95 9.7 0.0 3.2 5 0 0 5 5 5 0 FNIP Repeat NOC3p PF07540.11 EFA86195.1 - 1.4e-26 92.7 0.3 1.4e-26 92.7 0.3 3.0 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 EFA86195.1 - 5.9e-19 68.7 0.1 5.9e-19 68.7 0.1 4.2 4 1 0 4 4 4 1 CBF/Mak21 family adh_short_C2 PF13561.6 EFA86196.1 - 8.7e-59 198.9 0.2 1e-58 198.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFA86196.1 - 1.1e-44 152.3 0.5 1.3e-44 152.0 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFA86196.1 - 1.2e-10 41.5 0.1 2.1e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EFA86196.1 - 0.011 14.7 3.0 0.026 13.5 2.6 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFA86196.1 - 0.04 13.4 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family ATP_bind_2 PF03668.15 EFA86196.1 - 0.1 11.9 0.3 0.16 11.2 0.3 1.2 1 0 0 1 1 1 0 P-loop ATPase protein family zf-C3HC4_3 PF13920.6 EFA86197.1 - 3.3e-10 39.7 6.0 5.1e-10 39.1 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFA86197.1 - 1e-07 31.7 7.0 2.4e-07 30.5 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFA86197.1 - 1.5e-07 31.3 6.6 1.1e-05 25.4 2.2 2.4 2 0 0 2 2 2 2 RING-type zinc-finger zf-RING_2 PF13639.6 EFA86197.1 - 1.8e-07 31.3 8.4 3.5e-07 30.4 8.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFA86197.1 - 7.3e-07 29.0 3.8 1.1e-05 25.2 4.4 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFA86197.1 - 1.1e-06 28.4 6.7 4.6e-06 26.4 6.9 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFA86197.1 - 1.7e-05 24.9 4.5 0.00034 20.7 5.5 2.2 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFA86197.1 - 8.8e-05 22.4 7.1 0.00038 20.3 7.0 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-Di19 PF05605.12 EFA86197.1 - 0.0034 17.6 4.8 1.8 8.9 0.2 3.3 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding TerY_C PF15616.6 EFA86197.1 - 0.026 14.6 0.8 0.059 13.5 0.8 1.6 1 0 0 1 1 1 0 TerY-C metal binding domain zf-rbx1 PF12678.7 EFA86197.1 - 0.034 14.4 7.9 0.16 12.3 7.9 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain SUKH-3 PF14433.6 EFA86197.1 - 0.076 13.5 0.1 0.18 12.3 0.0 1.7 1 1 1 2 2 2 0 SUKH-3 immunity protein zf-ANAPC11 PF12861.7 EFA86197.1 - 0.24 11.5 4.9 1.4 9.0 4.4 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFA86197.1 - 0.25 11.2 7.9 1.4 8.8 7.5 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 EFA86197.1 - 0.31 11.0 3.5 0.74 9.8 3.4 1.6 1 1 0 1 1 1 0 zinc-ribbons zf-RING_6 PF14835.6 EFA86197.1 - 0.32 10.9 3.4 1 9.3 3.4 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 EFA86197.1 - 0.75 9.6 5.9 17 5.2 2.2 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-C2H2_9 PF16293.5 EFA86197.1 - 2.3 8.1 4.9 19 5.2 0.1 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) RecR PF02132.15 EFA86197.1 - 8.1 6.1 9.9 2.8 7.6 1.0 2.5 2 0 0 2 2 2 0 RecR protein LNS2 PF08235.13 EFA86198.1 - 3.6e-97 324.3 0.0 7e-97 323.3 0.0 1.5 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EFA86198.1 - 1.1e-37 128.0 0.1 5.5e-37 125.8 0.0 2.2 2 0 0 2 2 2 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 EFA86198.1 - 1.1e-22 80.0 0.0 5.3e-22 77.9 0.0 2.3 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain UPF0139 PF03669.13 EFA86199.1 - 3.2e-31 107.1 0.1 3.5e-31 106.9 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) SLC35F PF06027.12 EFA86199.1 - 0.017 14.7 0.3 0.019 14.5 0.3 1.1 1 0 0 1 1 1 0 Solute carrier family 35 TMEM43 PF07787.12 EFA86199.1 - 0.12 11.7 0.2 0.14 11.5 0.2 1.0 1 0 0 1 1 1 0 Transmembrane protein 43 UQ_con PF00179.26 EFA86200.1 - 3.2e-40 137.0 0.0 3.6e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EFA86200.1 - 0.0054 16.6 0.1 0.0085 15.9 0.1 1.3 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 EFA86200.1 - 0.13 11.9 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Ras PF00071.22 EFA86202.1 - 5.5e-44 149.6 0.1 2.2e-31 108.7 0.0 2.8 2 0 0 2 2 2 2 Ras family bMG10 PF17973.1 EFA86202.1 - 6.9e-26 91.0 0.0 6.9e-26 91.0 0.0 4.0 4 0 0 4 4 4 1 Bacterial Alpha-2-macroglobulin MG10 domain Roc PF08477.13 EFA86202.1 - 1.6e-14 54.1 0.0 2.1e-07 31.2 0.0 3.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase A2M_BRD PF07703.14 EFA86202.1 - 1.9e-13 50.9 0.0 1.9e-13 50.9 0.0 4.6 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain Big_5 PF13205.6 EFA86202.1 - 5.3e-11 43.2 4.2 1.8e-06 28.6 0.7 14.3 10 3 4 14 14 14 5 Bacterial Ig-like domain A2M PF00207.22 EFA86202.1 - 1.4e-09 37.7 2.0 4.3e-09 36.1 0.0 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFA86202.1 - 1.9e-08 34.6 0.2 1.5e-05 25.3 0.0 5.1 4 0 0 4 4 4 1 MG2 domain Arf PF00025.21 EFA86202.1 - 0.015 14.7 0.0 0.05 13.1 0.0 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family WH2 PF02205.20 EFA86202.1 - 0.18 11.7 0.5 0.64 9.9 0.5 1.9 1 0 0 1 1 1 0 WH2 motif PRIMA1 PF16101.5 EFA86203.1 - 0.022 14.8 1.5 0.03 14.4 1.5 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SMN PF06003.12 EFA86203.1 - 0.12 11.6 0.3 0.13 11.5 0.3 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Dscam_C PF12355.8 EFA86203.1 - 3 8.8 6.1 3.9 8.4 2.7 2.0 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Na_Ca_ex PF01699.24 EFA86204.1 - 1.4e-18 67.3 27.6 1.1e-09 38.5 10.4 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Wzy_C PF04932.15 EFA86204.1 - 0.0071 16.0 0.9 0.089 12.4 1.1 2.4 2 1 0 2 2 2 1 O-Antigen ligase SPT16 PF08644.11 EFA86204.1 - 0.21 11.7 0.1 0.21 11.7 0.1 3.0 3 0 0 3 3 3 0 FACT complex subunit (SPT16/CDC68) Tetraspanin PF00335.20 EFA86204.1 - 0.84 9.3 15.8 0.011 15.5 2.9 3.0 2 1 2 4 4 4 0 Tetraspanin family rve PF00665.26 EFA86210.1 - 5.2e-12 46.0 0.1 7.3e-12 45.5 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain DUF2787 PF10980.8 EFA86210.1 - 0.0011 19.1 0.3 0.0026 18.0 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2787) Integrase_H2C2 PF17921.1 EFA86210.1 - 0.69 10.1 7.9 1.4 9.1 7.9 1.6 1 0 0 1 1 1 0 Integrase zinc binding domain RT_RNaseH PF17917.1 EFA86211.1 - 0.0022 18.2 0.0 0.0031 17.8 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Dicty_REP PF05086.12 EFA86213.1 - 1.7 6.6 7.9 1.6 6.6 7.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 EFA86213.1 - 6.4 4.8 15.3 7.7 4.6 15.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 EFA86213.1 - 7.1 6.6 15.1 15 5.6 15.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pro-kuma_activ PF09286.11 EFA86214.1 - 1.7e-24 86.7 0.4 6.5e-24 84.8 0.0 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain FNIP PF05725.12 EFA86214.1 - 6.4e-21 74.2 25.8 1.6e-09 37.8 1.6 8.4 6 3 3 9 9 9 5 FNIP Repeat F-box_5 PF18511.1 EFA86214.1 - 0.014 15.0 0.1 0.03 13.9 0.1 1.5 1 0 0 1 1 1 0 F-box Bt_P21 PF05560.11 EFA86214.1 - 0.023 14.3 7.0 0.052 13.2 6.4 2.0 1 1 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein Cystatin PF00031.21 EFA86216.1 - 0.00096 19.4 0.0 0.0015 18.8 0.0 1.5 1 1 0 1 1 1 1 Cystatin domain Cystatin PF00031.21 EFA86217.1 - 1.7e-05 25.0 0.1 2.3e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EFA86217.1 - 0.073 13.4 0.2 0.088 13.2 0.2 1.3 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor EGF PF00008.27 EFA86218.1 - 1.9e-12 47.2 53.0 2.5e-05 24.5 6.6 5.2 4 0 0 4 4 4 4 EGF-like domain EGF_CA PF07645.15 EFA86218.1 - 1.6e-08 34.6 5.6 1.6e-08 34.6 5.6 5.3 5 0 0 5 5 5 2 Calcium-binding EGF domain TIG PF01833.24 EFA86218.1 - 3.7e-08 33.3 7.5 6e-06 26.2 2.3 6.3 5 2 2 7 7 7 2 IPT/TIG domain hEGF PF12661.7 EFA86218.1 - 2e-05 25.0 52.4 7.4e-05 23.2 4.1 6.7 5 0 0 5 5 5 3 Human growth factor-like EGF EGF_2 PF07974.13 EFA86218.1 - 0.00033 21.0 61.6 0.0041 17.5 13.3 5.7 4 1 1 5 5 5 3 EGF-like domain EGF_3 PF12947.7 EFA86218.1 - 0.00039 20.6 6.0 0.00039 20.6 6.0 6.3 6 0 0 6 6 6 2 EGF domain FXa_inhibition PF14670.6 EFA86218.1 - 0.00089 19.5 7.5 0.00089 19.5 7.5 5.7 5 0 0 5 5 5 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EFA86218.1 - 0.025 14.5 55.7 0.17 11.9 0.5 6.8 6 1 0 6 6 6 0 Complement Clr-like EGF-like EGF_Tenascin PF18720.1 EFA86218.1 - 9 6.5 26.6 0.12 12.4 10.4 3.5 2 0 0 2 2 2 0 Tenascin EGF domain WD40 PF00400.32 EFA86219.1 - 7.5e-09 36.1 1.9 0.0021 18.8 0.1 3.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA86219.1 - 2.6e-06 27.6 0.1 0.61 10.4 0.0 3.8 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_25 PF01183.20 EFA86220.1 - 5.6e-08 33.2 0.4 3.5e-07 30.6 0.1 2.0 1 1 1 2 2 2 1 Glycosyl hydrolases family 25 Pkinase_Tyr PF07714.17 EFA86222.1 - 1.8e-52 178.2 0.0 4.6e-52 176.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA86222.1 - 1.6e-45 155.6 0.0 4e-44 151.0 0.0 2.8 2 1 0 2 2 2 1 Protein kinase domain Pox_Ag35 PF03286.14 EFA86222.1 - 0.03 14.1 8.4 0.3 10.9 0.7 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 EFA86222.1 - 0.4 11.1 8.3 1.6 9.1 1.9 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 EFA86222.1 - 0.45 10.2 8.1 0.19 11.4 0.4 2.6 2 0 0 2 2 2 0 FAM176 family CENP-Q PF13094.6 EFA86222.1 - 1.3 9.2 5.2 11 6.2 5.9 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Cwf_Cwc_15 PF04889.12 EFA86222.1 - 1.7 8.3 12.2 0.1 12.3 2.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein ArgJ PF01960.18 EFA86223.1 - 2.3e-141 470.9 11.9 2.7e-141 470.7 11.9 1.0 1 0 0 1 1 1 1 ArgJ family Glyco_transf_56 PF07429.11 EFA86224.1 - 0.012 14.7 0.1 0.019 14.1 0.1 1.2 1 0 0 1 1 1 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Lipase_3 PF01764.25 EFA86225.1 - 4.5e-14 52.5 0.0 6.1e-13 48.8 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) CBM49 PF09478.10 EFA86225.1 - 3.7e-05 23.9 1.3 8.3e-05 22.8 0.3 2.1 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 TALPID3 PF15324.6 EFA86225.1 - 0.23 9.1 1.3 0.31 8.7 1.3 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Acetyltransf_1 PF00583.25 EFA86228.1 - 1.4e-10 41.5 0.1 1.8e-10 41.0 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFA86228.1 - 1.2e-08 34.9 0.0 1.3e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFA86228.1 - 5.4e-08 32.7 0.0 1e-07 31.8 0.0 1.4 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.7 EFA86228.1 - 1e-07 32.2 0.0 1.4e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFA86228.1 - 2.2e-05 24.5 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain SPOR PF05036.13 EFA86228.1 - 0.039 14.3 0.0 0.064 13.7 0.0 1.5 1 1 0 1 1 1 0 Sporulation related domain MIT_C PF16565.5 EFA86229.1 - 1.4e-43 148.3 0.4 3.2e-43 147.1 0.4 1.6 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT MIT PF04212.18 EFA86229.1 - 2.6e-19 69.1 2.5 3.9e-19 68.5 2.5 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 EFA86229.1 - 0.0035 17.3 0.1 0.0074 16.2 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat RE_HindVP PF09519.10 EFA86229.1 - 0.014 14.4 0.1 0.014 14.4 0.1 1.6 2 0 0 2 2 2 0 HindVP restriction endonuclease T3SS_ATPase_C PF18269.1 EFA86229.1 - 0.016 15.1 0.3 0.096 12.6 0.1 2.2 2 0 0 2 2 2 0 T3SS EscN ATPase C-terminal domain Use1 PF09753.9 EFA86229.1 - 0.018 14.8 0.2 0.032 13.9 0.2 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 TPR_2 PF07719.17 EFA86229.1 - 0.025 14.7 0.1 0.054 13.6 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86229.1 - 0.037 14.3 0.2 0.065 13.5 0.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat USP8_dimer PF08969.11 EFA86229.1 - 0.24 11.6 4.4 0.47 10.7 2.6 2.2 2 1 0 2 2 2 0 USP8 dimerisation domain Med22 PF06179.12 EFA86230.1 - 2.8e-23 82.1 12.4 2.8e-23 82.1 12.4 2.4 3 0 0 3 3 3 1 Surfeit locus protein 5 subunit 22 of Mediator complex Tctex-1 PF03645.13 EFA86230.1 - 0.004 17.4 0.8 0.004 17.4 0.8 2.3 1 1 1 2 2 2 1 Tctex-1 family DLP_helical PF18709.1 EFA86230.1 - 3.3 6.8 20.0 0.27 10.4 4.1 2.1 1 1 1 2 2 2 0 Dynamin-like helical domain DUF4770 PF15994.5 EFA86230.1 - 5.4 7.2 23.3 0.11 12.8 13.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4770) PMC2NT PF08066.12 EFA86230.1 - 5.8 7.7 7.5 0.45 11.2 0.5 2.5 2 1 0 3 3 3 0 PMC2NT (NUC016) domain tRNA_synt_1c_R2 PF04557.15 EFA86230.1 - 6.1 7.8 9.8 2.6 9.0 6.0 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Mito_carr PF00153.27 EFA86232.1 - 3.3e-75 248.1 0.0 1.2e-26 92.5 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EFA86232.1 - 4.5e-20 71.9 4.9 5.8e-09 36.3 0.5 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 EFA86232.1 - 2.8e-18 64.0 11.6 5.2e-05 22.5 0.1 6.1 8 0 0 8 8 8 4 EF hand EF-hand_6 PF13405.6 EFA86232.1 - 3.2e-18 64.1 11.2 2.3e-05 23.9 0.2 6.6 7 0 0 7 7 7 4 EF-hand domain EF-hand_8 PF13833.6 EFA86232.1 - 4.2e-11 42.5 2.7 0.011 15.5 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFA86232.1 - 4.2e-09 35.5 11.5 0.0039 16.6 0.2 4.4 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.7 EFA86232.1 - 0.00051 20.0 0.3 0.35 10.9 0.0 3.0 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFA86232.1 - 0.02 15.2 0.1 0.77 10.1 0.0 3.0 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Coilin_N PF15862.5 EFA86233.1 - 0.0044 16.8 0.0 0.0044 16.8 0.0 3.8 3 2 1 4 4 4 1 Coilin N-terminus G-alpha PF00503.20 EFA86235.1 - 1.2e-100 337.1 23.7 1.2e-100 337.1 23.7 4.1 2 2 0 2 2 2 1 G-protein alpha subunit Arf PF00025.21 EFA86235.1 - 7e-10 38.6 1.4 2.5e-07 30.3 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family PH PF00169.29 EFA86235.1 - 2e-08 34.7 0.2 2e-08 34.7 0.2 4.2 4 1 0 4 4 4 1 PH domain Rsa3 PF14615.6 EFA86235.1 - 3.1e-07 29.9 0.4 1e-06 28.2 0.2 2.0 2 0 0 2 2 2 1 Ribosome-assembly protein 3 Roc PF08477.13 EFA86235.1 - 0.0035 17.5 0.1 2.7 8.2 0.0 3.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_14 PF17959.1 EFA86235.1 - 3.1 8.2 7.3 0.5 10.8 0.6 3.1 2 0 0 2 2 2 0 EF-hand domain Sulfotransfer_2 PF03567.14 EFA86236.1 - 3.5e-11 43.5 0.4 3.5e-11 43.5 0.4 2.7 2 1 0 2 2 2 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 EFA86236.1 - 1.9e-06 27.1 0.1 3.9e-05 22.7 0.0 2.0 2 0 0 2 2 2 2 Galactose-3-O-sulfotransferase COMM_domain PF07258.14 EFA86237.1 - 3.9e-17 62.1 0.3 1.3e-16 60.5 0.1 2.0 2 0 0 2 2 2 1 COMM domain Nodulin-like PF06813.13 EFA86238.1 - 0.005 16.4 0.0 0.0063 16.0 0.0 1.1 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 EFA86239.1 - 4.5e-17 62.0 9.6 2.3e-09 36.7 9.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.13 EFA86240.1 - 4e-26 92.0 0.1 5.2e-26 91.6 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFA86240.1 - 0.00089 19.2 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Mg296 PF09644.10 EFA86240.1 - 0.1 12.8 0.1 0.19 11.9 0.1 1.6 1 1 0 1 1 1 0 Mg296 protein Methyltransf_16 PF10294.9 EFA86241.1 - 1e-26 93.7 1.9 1e-13 51.4 0.2 2.4 1 1 1 2 2 2 2 Lysine methyltransferase MTS PF05175.14 EFA86241.1 - 2.4e-05 23.9 0.0 4.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EFA86241.1 - 5e-05 23.9 0.0 9.3e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFA86241.1 - 0.00059 19.3 0.1 0.001 18.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFA86241.1 - 0.0013 18.5 0.7 0.0079 16.0 0.7 2.2 1 1 0 1 1 1 1 Methyltransferase domain FAM86 PF14904.6 EFA86241.1 - 0.0023 18.0 0.1 3.3 7.9 0.0 2.5 2 0 0 2 2 2 2 Family of unknown function Methyltransf_12 PF08242.12 EFA86241.1 - 0.046 14.5 0.2 0.12 13.1 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFA86241.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain FAST_1 PF06743.15 EFA86241.1 - 0.32 11.0 4.5 0.38 10.7 0.0 3.0 3 1 1 4 4 4 0 FAST kinase-like protein, subdomain 1 Spc7 PF08317.11 EFA86242.1 - 0.00089 18.2 19.8 0.00089 18.2 19.8 4.2 2 1 1 4 4 4 2 Spc7 kinetochore protein ATG16 PF08614.11 EFA86242.1 - 0.0031 17.8 18.2 0.0031 17.8 18.2 6.2 2 1 3 5 5 5 1 Autophagy protein 16 (ATG16) NmrA PF05368.13 EFA86243.1 - 1.6e-26 93.3 0.6 2.1e-26 92.9 0.6 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFA86243.1 - 1.3e-06 28.4 0.0 2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EFA86243.1 - 0.024 14.6 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 KR domain TrkA_N PF02254.18 EFA86243.1 - 0.029 14.6 0.1 0.059 13.6 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain 3Beta_HSD PF01073.19 EFA86243.1 - 0.13 11.2 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Med10 PF09748.9 EFA86244.1 - 8.8e-26 90.3 0.7 1.4e-25 89.6 0.7 1.3 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Hva1_TUDOR PF11160.8 EFA86244.1 - 0.098 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Hypervirulence associated proteins TUDOR domain TSC22 PF01166.18 EFA86244.1 - 0.37 11.2 4.1 0.19 12.1 1.1 2.0 2 0 0 2 2 2 0 TSC-22/dip/bun family Rtt106 PF08512.12 EFA86245.1 - 1.4e-28 99.1 2.2 3.6e-25 88.2 0.3 2.9 3 0 0 3 3 3 2 Histone chaperone Rttp106-like POB3_N PF17292.2 EFA86245.1 - 7.5e-27 93.6 1.1 9.2e-23 80.5 0.1 3.6 3 0 0 3 3 3 2 POB3-like N-terminal PH domain SSrecog PF03531.14 EFA86245.1 - 3.1e-19 68.6 3.2 1.1e-18 66.9 0.1 2.8 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) Dehydratase_LU PF02286.15 EFA86245.1 - 0.0023 16.6 0.1 0.01 14.4 0.0 1.8 2 0 0 2 2 2 1 Dehydratase large subunit DUF4636 PF15468.6 EFA86245.1 - 0.077 12.7 4.8 0.13 12.0 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) NOA36 PF06524.12 EFA86245.1 - 1.6 8.0 10.3 3.4 6.9 10.3 1.5 1 0 0 1 1 1 0 NOA36 protein PH_TFIIH PF08567.11 EFA86245.1 - 2 8.8 5.9 28 5.1 0.0 4.1 4 0 0 4 4 4 0 TFIIH p62 subunit, N-terminal domain CDC45 PF02724.14 EFA86245.1 - 2.8 6.1 10.2 4.2 5.5 10.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DENN PF02141.21 EFA86246.1 - 4.3e-28 98.5 2.1 1.4e-27 96.8 2.1 1.9 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EFA86246.1 - 4.6e-06 27.3 2.9 5.4e-06 27.1 0.2 2.6 2 1 0 2 2 2 1 uDENN domain EB1 PF03271.17 EFA86247.1 - 0.11 12.8 0.5 0.49 10.7 0.1 2.3 3 0 0 3 3 3 0 EB1-like C-terminal motif FAST_1 PF06743.15 EFA86249.1 - 0.035 14.0 2.3 0.1 12.6 0.4 2.3 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 GSDH PF07995.11 EFA86249.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase PWWP PF00855.17 EFA86250.1 - 2.1e-06 28.1 0.2 1e-05 25.8 0.0 2.4 2 0 0 2 2 2 1 PWWP domain DUF5617 PF18493.1 EFA86250.1 - 0.044 13.9 6.6 0.16 12.1 6.6 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) RGS PF00615.19 EFA86251.1 - 2.1e-26 92.5 2.5 2.7e-26 92.2 2.5 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Chs7 PF12271.8 EFA86253.1 - 0.079 12.3 2.0 0.086 12.2 2.0 1.0 1 0 0 1 1 1 0 Chitin synthase export chaperone WD40 PF00400.32 EFA86254.1 - 2.5e-17 62.9 6.2 0.49 11.3 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA86254.1 - 1.3e-09 38.2 0.0 0.00024 21.3 0.0 3.5 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA86254.1 - 2.5e-06 27.0 4.1 1e-05 25.0 2.5 2.1 1 1 2 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 EFA86254.1 - 4.8e-06 25.4 0.4 0.012 14.2 0.2 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 EFA86254.1 - 0.00052 18.8 0.2 0.76 8.3 0.1 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EFA86254.1 - 0.00075 19.9 0.0 20 5.8 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain BBS2_Mid PF14783.6 EFA86254.1 - 0.0019 18.2 0.4 0.37 10.8 0.1 3.1 1 1 2 3 3 3 2 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EFA86254.1 - 0.0042 17.0 0.1 1.6 8.5 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nop53 PF07767.11 EFA86254.1 - 0.005 16.3 16.9 0.0073 15.7 16.9 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) PQQ PF01011.21 EFA86254.1 - 0.025 14.5 0.3 2.3 8.3 0.0 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 EFA86254.1 - 0.044 12.7 0.0 1.1 8.1 0.0 3.0 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nop14 PF04147.12 EFA86254.1 - 0.19 9.9 32.8 0.25 9.5 32.8 1.1 1 0 0 1 1 1 0 Nop14-like family Rubella_Capsid PF05750.11 EFA86254.1 - 0.62 9.6 4.0 0.91 9.1 4.0 1.1 1 0 0 1 1 1 0 Rubella capsid protein Hid1 PF12722.7 EFA86254.1 - 0.72 7.9 6.0 0.96 7.5 6.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 EFA86254.1 - 1.7 7.9 34.8 2.2 7.5 34.8 1.1 1 0 0 1 1 1 0 BUD22 RCC1 PF00415.18 EFA86255.1 - 1.8e-46 156.5 5.5 8.9e-11 42.2 0.0 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA86255.1 - 2.9e-23 81.1 25.8 5.5e-07 29.2 0.2 7.1 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RabGAP-TBC PF00566.18 EFA86256.1 - 5.2e-25 88.4 8.2 5.2e-25 88.4 8.2 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF3430 PF11912.8 EFA86257.1 - 5.9e-06 26.5 31.5 5.9e-06 26.5 31.5 3.5 2 1 1 3 3 3 1 Protein of unknown function (DUF3430) fn3 PF00041.21 EFA86257.1 - 0.00015 22.0 0.4 0.078 13.3 0.0 3.5 3 0 0 3 3 3 2 Fibronectin type III domain Pkinase_Tyr PF07714.17 EFA86258.1 - 4.9e-44 150.6 0.0 2.5e-42 144.9 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFA86258.1 - 9.1e-39 133.4 0.0 5.1e-38 131.0 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFA86258.1 - 9.2e-20 71.0 7.7 8.1e-10 39.2 0.2 4.3 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86258.1 - 2.1e-16 60.0 1.4 6.3e-10 39.4 0.1 4.9 2 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA86258.1 - 1.9e-12 47.2 3.8 0.00073 19.8 0.0 5.8 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86258.1 - 1.4e-11 43.5 7.5 0.003 17.9 0.0 6.5 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFA86258.1 - 6.5e-10 39.0 8.9 0.00033 21.0 0.1 6.4 6 0 0 6 6 6 2 Ankyrin repeat APH PF01636.23 EFA86258.1 - 0.0086 16.0 0.3 0.039 13.9 0.0 2.0 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFA86258.1 - 0.009 15.4 2.1 0.035 13.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DnaB_2 PF07261.11 EFA86258.1 - 4.7 7.0 8.5 5.8 6.7 4.2 2.7 2 0 0 2 2 2 0 Replication initiation and membrane attachment Peptidase_M22 PF00814.25 EFA86259.1 - 8.3e-86 288.0 0.0 9.5e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family zf-CHCC PF10276.9 EFA86260.1 - 3.6e-17 62.1 1.1 4.9e-17 61.7 1.1 1.2 1 0 0 1 1 1 1 Zinc-finger domain Arf PF00025.21 EFA86261.1 - 5.6e-48 162.7 0.2 6.5e-48 162.5 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFA86261.1 - 6.3e-15 55.4 0.0 1.2e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFA86261.1 - 2.2e-13 50.0 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFA86261.1 - 2.4e-11 43.5 0.1 2.7e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFA86261.1 - 1.3e-09 38.2 0.0 1.9e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFA86261.1 - 4.4e-08 32.7 0.4 3.4e-06 26.5 0.0 2.5 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFA86261.1 - 2e-06 27.3 0.2 2.6e-06 27.0 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFA86261.1 - 0.00021 20.9 0.2 0.0013 18.3 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFA86261.1 - 0.0015 18.1 0.6 0.011 15.2 0.6 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Sipho_tail PF05709.11 EFA86261.1 - 0.051 13.0 0.1 0.15 11.5 0.1 1.7 1 1 0 1 1 1 0 Phage tail protein cobW PF02492.19 EFA86261.1 - 0.095 12.3 0.5 0.89 9.1 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CARD_2 PF16739.5 EFA86261.1 - 0.13 12.3 0.9 2 8.5 0.9 2.2 1 1 0 1 1 1 0 Caspase recruitment domain AAA_18 PF13238.6 EFA86261.1 - 0.16 12.5 0.5 0.87 10.1 0.2 2.1 1 1 1 2 2 2 0 AAA domain Epimerase PF01370.21 EFA86262.1 - 7.3e-09 35.4 0.0 1.7e-07 30.9 0.0 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFA86262.1 - 1e-07 32.0 0.0 3e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EFA86262.1 - 4.9e-05 23.0 0.1 0.0018 17.9 0.1 2.1 2 0 0 2 2 2 1 NmrA-like family 3HCDH_N PF02737.18 EFA86262.1 - 0.0099 15.8 0.2 1.2 9.0 0.2 2.5 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 EFA86262.1 - 0.026 14.0 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DXP_reductoisom PF02670.16 EFA86262.1 - 0.034 14.9 0.4 0.16 12.6 0.0 2.2 3 0 0 3 3 3 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Polysacc_synt_2 PF02719.15 EFA86262.1 - 0.041 13.0 0.1 0.19 10.9 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NAD_binding_2 PF03446.15 EFA86262.1 - 0.042 14.0 0.0 0.099 12.8 0.0 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EFA86262.1 - 0.062 13.6 0.2 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Transglut_core PF01841.19 EFA86263.1 - 3.9e-09 36.9 0.0 8.2e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Tcp10_C PF07202.13 EFA86263.1 - 0.08 12.9 0.3 0.18 11.7 0.3 1.5 1 0 0 1 1 1 0 T-complex protein 10 C-terminus Dickkopf_N PF04706.12 EFA86264.1 - 0.013 16.0 0.4 0.014 15.8 0.4 1.1 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Nodulin_late PF07127.11 EFA86264.1 - 0.085 13.2 2.0 0.17 12.3 2.0 1.4 1 1 0 1 1 1 0 Late nodulin protein Menin PF05053.13 EFA86265.1 - 0.2 10.0 5.4 0.26 9.6 5.4 1.1 1 0 0 1 1 1 0 Menin RabGAP-TBC PF00566.18 EFA86266.1 - 2.9e-47 161.1 12.2 6.3e-46 156.7 12.2 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain WD40 PF00400.32 EFA86267.1 - 2.9e-07 31.0 7.5 0.13 13.2 0.1 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF4384 PF14326.6 EFA86267.1 - 0.065 13.4 0.2 43 4.3 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4384) NTF2 PF02136.20 EFA86268.1 - 4.2e-18 66.0 0.5 4.2e-18 66.0 0.5 1.9 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EFA86268.1 - 6.6e-07 29.1 0.4 1.5e-06 28.0 0.4 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Coilin_N PF15862.5 EFA86268.1 - 5.4 6.8 15.8 2.5 7.9 7.5 2.5 2 0 0 2 2 2 0 Coilin N-terminus zf-PARP PF00645.18 EFA86269.1 - 8.1e-20 71.5 6.8 9.1e-20 71.3 0.4 3.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-CCHH PF10283.9 EFA86269.1 - 2.3e-11 43.5 2.6 4.4e-11 42.5 2.6 1.5 1 0 0 1 1 1 1 PBZ domain UDG PF03167.19 EFA86269.1 - 1e-06 28.9 0.0 6e-06 26.3 0.0 2.2 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily DinB PF05163.12 EFA86269.1 - 9 6.2 7.3 2.7 7.9 0.1 2.9 3 0 0 3 3 3 0 DinB family RRM_1 PF00076.22 EFA86270.1 - 1.4e-43 146.5 2.5 2.2e-15 56.2 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFA86270.1 - 0.0048 17.0 1.1 3.2 8.0 0.0 3.5 3 1 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 EFA86270.1 - 0.064 13.1 0.2 3.7 7.5 0.1 2.7 3 0 0 3 3 3 0 Occluded RNA-recognition motif Nup35_RRM PF05172.13 EFA86270.1 - 0.077 13.0 1.6 1.1 9.2 0.0 2.5 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EFA86270.1 - 0.13 12.4 1.5 1.1 9.5 0.6 2.6 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF3439 PF11921.8 EFA86270.1 - 0.28 11.2 6.3 0.76 9.7 6.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ribosomal_L3 PF00297.22 EFA86271.1 - 1.4e-15 57.2 3.0 1.8e-14 53.5 0.4 2.6 1 1 2 3 3 3 2 Ribosomal protein L3 PKI PF02827.16 EFA86271.1 - 0.01 16.0 0.6 0.019 15.1 0.6 1.5 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Glutaredoxin PF00462.24 EFA86272.1 - 4.3e-18 65.3 0.0 8.1e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Arv1 PF04161.13 EFA86273.1 - 1.7e-39 136.2 8.3 6.4e-31 108.1 0.6 2.0 1 1 1 2 2 2 2 Arv1-like family DZR PF12773.7 EFA86273.1 - 0.015 15.3 0.2 0.02 14.9 0.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon MPS-4 PF17523.2 EFA86273.1 - 2.6 8.2 9.2 2 8.6 0.2 2.6 1 1 1 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Arf PF00025.21 EFA86274.1 - 9.7e-22 77.2 0.0 2e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family 2OG-FeII_Oxy_3 PF13640.6 EFA86274.1 - 1.6e-13 51.3 0.1 8.2e-13 49.1 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily F-box PF00646.33 EFA86274.1 - 4.7e-05 23.2 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA86274.1 - 0.00078 19.3 0.1 0.0015 18.4 0.1 1.5 1 0 0 1 1 1 1 F-box-like Pox_C4_C10 PF03336.13 EFA86274.1 - 0.0038 16.4 0.0 0.0084 15.3 0.0 1.5 1 0 0 1 1 1 1 Poxvirus C4/C10 protein PhyH PF05721.13 EFA86274.1 - 0.028 14.7 0.0 2.9 8.1 0.0 2.5 1 1 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) DUF167 PF02594.16 EFA86275.1 - 1.5e-12 47.5 0.2 1.8e-12 47.2 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Ssl1 PF04056.14 EFA86276.1 - 3.3e-73 245.6 0.8 4.4e-73 245.2 0.8 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EFA86276.1 - 2.2e-13 50.2 25.9 9.8e-13 48.1 13.1 3.1 2 1 0 2 2 2 2 TFIIH C1-like domain VWA_2 PF13519.6 EFA86276.1 - 9.2e-11 42.3 0.0 1.6e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.14 EFA86276.1 - 0.79 9.2 8.9 1.1 8.7 8.9 1.5 1 1 0 1 1 1 0 Transcription factor Tfb4 DZR PF12773.7 EFA86276.1 - 1.1 9.3 18.0 17 5.5 7.3 3.0 1 1 1 2 2 2 0 Double zinc ribbon Mito_carr PF00153.27 EFA86277.1 - 5.7e-56 186.4 4.1 2.6e-21 75.3 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein SRR1 PF07985.12 EFA86277.1 - 1.7e-15 56.8 0.0 3.2e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 SRR1 T3SchapCesA PF11439.8 EFA86277.1 - 0.0029 17.7 3.5 0.0075 16.4 3.0 1.9 2 0 0 2 2 2 1 Type III secretion system filament chaperone CesA Peptidase_M32 PF02074.15 EFA86277.1 - 0.078 11.7 1.0 0.13 11.0 1.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase Mucin PF01456.17 EFA86278.1 - 0.0014 18.6 1.3 0.0019 18.2 1.3 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein DDE_Tnp_4 PF13359.6 EFA86279.1 - 0.0015 18.2 0.0 0.0016 18.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA86279.1 - 0.023 14.3 0.0 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 Transposase DDE domain RPA43_OB PF17875.1 EFA86280.1 - 0.017 15.8 2.0 0.023 15.3 2.0 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I NOA36 PF06524.12 EFA86280.1 - 0.12 11.6 3.7 0.13 11.6 3.7 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 EFA86280.1 - 2 8.8 7.7 2.9 8.3 7.4 1.5 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DDE_Tnp_4 PF13359.6 EFA86281.1 - 6.3e-12 45.4 0.0 1.3e-11 44.4 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease AAA_14 PF13173.6 EFA86282.1 - 0.023 14.7 0.1 0.11 12.6 0.1 2.2 1 1 0 1 1 1 0 AAA domain EPL1 PF10513.9 EFA86282.1 - 0.13 12.7 5.0 0.99 9.8 0.9 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like RNA_helicase PF00910.22 EFA86282.1 - 0.17 12.3 2.2 0.51 10.8 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_11 PF13086.6 EFA86282.1 - 0.92 9.2 0.0 0.92 9.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF1387 PF07139.11 EFA86282.1 - 7 6.3 10.5 1.2 8.8 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) DUF1829 PF08862.10 EFA86284.1 - 0.77 10.3 7.0 0.13 12.8 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF1829 F-box_5 PF18511.1 EFA86285.1 - 6.8e-07 28.8 0.9 3.2e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 EFA86285.1 - 0.057 13.3 0.5 0.17 11.8 0.2 1.9 2 0 0 2 2 2 0 F-box-like ArgJ PF01960.18 EFA86285.1 - 0.16 10.6 0.3 0.23 10.1 0.3 1.1 1 0 0 1 1 1 0 ArgJ family DNA_pol_B_palm PF14792.6 EFA86286.1 - 5.7e-32 110.3 0.2 1.6e-31 108.8 0.2 1.8 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EFA86286.1 - 5.1e-23 81.0 0.4 1.3e-22 79.8 0.1 1.9 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EFA86286.1 - 6.2e-15 54.8 0.0 1.6e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EFA86286.1 - 4.2e-14 52.7 0.1 4.5e-13 49.4 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain BRCT_2 PF16589.5 EFA86286.1 - 6e-06 26.6 0.7 6e-06 26.6 0.7 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFA86286.1 - 5.5e-05 23.5 0.6 0.00018 21.8 0.6 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain HHH_5 PF14520.6 EFA86286.1 - 0.00016 22.2 0.2 0.0095 16.5 0.3 2.1 1 1 1 2 2 2 2 Helix-hairpin-helix domain Fimbrial_CS1 PF04449.12 EFA86286.1 - 5.7 7.1 9.0 0.18 11.9 0.2 2.9 3 1 1 4 4 4 0 CS1 type fimbrial major subunit Aa_trans PF01490.18 EFA86287.1 - 2.3e-51 174.8 29.8 3e-51 174.4 29.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein BCAS2 PF05700.11 EFA86287.1 - 3.5e-31 108.5 14.5 5.1e-31 108.0 14.5 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) HofP PF10748.9 EFA86287.1 - 0.011 15.2 0.2 0.16 11.6 0.2 2.2 2 0 0 2 2 2 0 DNA utilization proteins HofP E2 PF08199.11 EFA86287.1 - 1.2 9.2 5.5 0.66 10.0 0.3 2.8 2 0 0 2 2 2 0 Bacteriophage E2-like protein BCAS2 PF05700.11 EFA86288.1 - 1.2e-09 38.2 0.1 1.3e-09 38.1 0.1 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) MitoNEET_N PF10660.9 EFA86288.1 - 0.012 15.6 0.1 0.016 15.2 0.1 1.3 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Clathrin_lg_ch PF01086.17 EFA86289.1 - 1.8e-13 51.1 24.3 1.1e-12 48.5 24.3 1.9 1 1 0 1 1 1 1 Clathrin light chain Macoilin PF09726.9 EFA86289.1 - 0.11 11.0 21.4 0.13 10.8 21.4 1.0 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 EFA86289.1 - 6.2 7.3 12.8 7.9 7.0 12.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4644 PF15486.6 EFA86289.1 - 9.6 5.9 7.5 0.85 9.4 2.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4644) zn-ribbon_14 PF16503.5 EFA86290.1 - 2.5e-14 52.5 6.2 2.5e-14 52.5 6.2 4.2 5 0 0 5 5 5 1 Zinc-ribbon ATP_bind_3 PF01171.20 EFA86290.1 - 2.2e-13 50.4 0.0 1.4e-12 47.8 0.0 2.1 2 0 0 2 2 2 1 PP-loop family CTU2 PF10288.9 EFA86290.1 - 0.024 14.9 2.0 0.024 14.9 2.0 3.2 3 1 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 PDEase_I PF00233.19 EFA86290.1 - 0.036 13.8 0.1 0.036 13.8 0.1 1.7 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase zf-AD PF07776.15 EFA86290.1 - 0.44 10.8 6.2 0.25 11.6 0.9 2.6 2 1 0 2 2 2 0 Zinc-finger associated domain (zf-AD) DUF2616 PF11077.8 EFA86290.1 - 0.51 10.0 9.6 0.032 14.0 1.9 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) ABC_tran PF00005.27 EFA86292.1 - 2e-24 86.6 0.0 3.6e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFA86292.1 - 7.7e-18 64.7 34.6 1.2e-17 64.0 34.6 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFA86292.1 - 3.2e-09 37.0 0.0 0.00011 22.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA86292.1 - 0.055 12.9 0.1 14 5.0 0.0 3.1 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA86292.1 - 0.099 12.4 0.1 0.31 10.8 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4162 PF13732.6 EFA86292.1 - 0.14 12.8 0.1 0.29 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) AAA_23 PF13476.6 EFA86292.1 - 0.18 12.3 0.4 0.43 11.1 0.4 1.6 1 0 0 1 1 1 0 AAA domain AF-4 PF05110.13 EFA86294.1 - 0.1 10.7 4.5 0.12 10.4 4.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 EFA86294.1 - 0.48 10.0 7.0 0.74 9.4 7.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF962 PF06127.11 EFA86296.1 - 5.2e-11 42.5 0.1 6.7e-11 42.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF962) DUF2200 PF09966.9 EFA86296.1 - 0.16 12.2 0.1 0.18 12.0 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) Dicty_CAR PF05462.11 EFA86297.1 - 1.2e-08 34.5 11.9 1.7e-08 34.0 11.9 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EFA86297.1 - 3.4e-07 29.8 19.3 9.2e-07 28.4 19.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) Frizzled PF01534.17 EFA86297.1 - 0.00017 20.8 18.5 0.0018 17.4 4.9 2.4 1 1 1 2 2 2 2 Frizzled/Smoothened family membrane region ABC_tran PF00005.27 EFA86298.1 - 8.1e-40 136.5 0.0 3.2e-22 79.5 0.0 4.4 4 1 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EFA86298.1 - 8e-18 64.2 9.5 8e-18 64.2 9.5 7.4 4 1 3 7 7 2 1 ABC transporter AAA_21 PF13304.6 EFA86298.1 - 6.4e-08 32.7 14.1 0.015 15.1 0.7 5.4 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFA86298.1 - 3.9e-07 30.1 0.0 0.0039 17.1 0.0 2.9 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EFA86298.1 - 9.9e-07 29.3 0.9 0.0018 18.7 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFA86298.1 - 5.9e-06 26.4 0.4 0.0074 16.4 0.0 3.6 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFA86298.1 - 2.3e-05 24.7 0.0 0.2 11.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EFA86298.1 - 0.00029 21.3 0.0 0.23 11.9 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFA86298.1 - 0.00076 19.4 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.22 EFA86298.1 - 0.001 19.4 0.0 0.87 10.0 0.0 3.1 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 EFA86298.1 - 0.0021 18.2 0.0 0.49 10.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EFA86298.1 - 0.0032 17.7 0.5 1.5 9.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EFA86298.1 - 0.004 16.9 4.7 0.044 13.5 0.1 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_7 PF12775.7 EFA86298.1 - 0.0059 16.1 0.0 1.8 8.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 EFA86298.1 - 0.02 14.9 0.0 1 9.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFA86298.1 - 0.026 14.5 0.0 2.3 8.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EFA86298.1 - 0.079 13.0 0.0 0.079 13.0 0.0 5.7 4 1 0 4 4 3 0 Helicase HerA, central domain Roc PF08477.13 EFA86298.1 - 0.086 13.1 2.0 2.4 8.4 0.0 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 EFA86298.1 - 0.17 10.9 2.6 2.8 6.8 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Glyco_transf_49 PF13896.6 EFA86299.1 - 2.2e-54 185.1 3.0 2.8e-44 151.8 1.7 2.1 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 EFA86299.1 - 0.0021 17.9 0.0 0.0037 17.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Baculo_11_kDa PF06143.11 EFA86299.1 - 0.012 15.2 1.1 2.1 8.0 0.0 2.6 2 0 0 2 2 2 0 Baculovirus 11 kDa family Glyco_tranf_2_4 PF13704.6 EFA86299.1 - 0.039 14.5 0.1 0.096 13.2 0.1 1.7 1 1 0 1 1 1 0 Glycosyl transferase family 2 PRP3 PF08572.10 EFA86301.1 - 8e-50 169.6 3.4 8e-50 169.6 3.4 3.3 3 1 1 4 4 4 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EFA86301.1 - 4.5e-38 130.6 0.0 4.5e-38 130.6 0.0 4.2 4 1 0 4 4 4 1 Protein of unknown function (DUF1115) Glyco_transf_10 PF00852.19 EFA86302.1 - 5.3e-30 104.4 0.1 1.5e-29 103.0 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_trans_1_2 PF13524.6 EFA86302.1 - 0.00022 21.5 0.0 0.00043 20.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Mrpl_C PF18502.1 EFA86303.1 - 0.028 14.7 1.4 0.042 14.1 0.9 1.6 1 1 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain Mucin PF01456.17 EFA86304.1 - 1.1 9.2 14.1 1.1 9.3 14.1 1.0 1 0 0 1 1 1 0 Mucin-like glycoprotein Tir_receptor_C PF07489.11 EFA86304.1 - 1.2 9.1 9.9 1.1 9.2 9.9 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EFA86304.1 - 5 5.0 9.2 4.4 5.2 9.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EFA86304.1 - 8.3 6.4 12.9 9.1 6.3 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) rve PF00665.26 EFA86305.1 - 2.2e-13 50.5 0.1 3.1e-12 46.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 EFA86305.1 - 0.00042 19.9 0.0 0.00087 18.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RMI1_N PF08585.12 EFA86307.1 - 2.5e-20 73.2 0.0 2.5e-20 73.2 0.0 4.1 2 1 2 4 4 4 2 RecQ mediated genome instability protein RMI1_C PF16099.5 EFA86307.1 - 1.9e-09 37.5 0.9 5e-09 36.1 0.2 2.1 2 0 0 2 2 2 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Mucin PF01456.17 EFA86307.1 - 0.00086 19.3 15.4 0.0019 18.2 15.4 1.6 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF4834 PF16118.5 EFA86307.1 - 0.85 10.6 11.2 0.62 11.1 1.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SIP1 PF04938.12 EFA86308.1 - 0.054 13.2 0.0 0.055 13.2 0.0 1.0 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) FNIP_M PF14637.6 EFA86309.1 - 2.6e-65 220.6 4.4 4.6e-65 219.8 4.4 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 EFA86309.1 - 2e-19 70.0 0.0 6.7e-19 68.3 0.0 1.9 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 EFA86309.1 - 2.3e-09 38.4 0.0 2.3e-09 38.4 0.0 5.2 3 2 1 4 4 4 1 Folliculin-interacting protein N-terminus Longin_2 PF18639.1 EFA86309.1 - 0.005 16.7 0.0 0.017 15.0 0.0 1.9 1 0 0 1 1 1 1 Yeast longin domain T4SS_TraI PF16932.5 EFA86309.1 - 0.1 11.8 0.3 0.2 10.8 0.3 1.4 1 0 0 1 1 1 0 Type IV secretory system, conjugal DNA-protein transfer PPTA PF01239.22 EFA86310.1 - 1.7e-16 59.3 14.1 2.1e-06 27.3 0.7 5.3 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat TRM PF02005.16 EFA86311.1 - 1.5e-129 432.4 0.1 2.4e-129 431.8 0.1 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase zf-CCCH_4 PF18044.1 EFA86311.1 - 0.0019 17.9 0.9 0.0052 16.6 0.9 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EFA86311.1 - 0.017 15.8 1.4 0.017 15.8 1.4 2.2 2 1 1 3 3 3 0 Torus domain Methyltransf_31 PF13847.6 EFA86311.1 - 0.021 14.6 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain zf_CCCH_4 PF18345.1 EFA86311.1 - 0.03 14.4 1.6 0.03 14.4 1.6 2.1 2 0 0 2 2 2 0 Zinc finger domain PrmA PF06325.13 EFA86311.1 - 0.034 13.5 0.1 0.034 13.5 0.1 1.7 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) SNF2_N PF00176.23 EFA86312.1 - 3.2e-36 124.8 1.6 7.9e-22 77.4 0.3 6.3 5 2 2 7 7 7 2 SNF2 family N-terminal domain Bromodomain PF00439.25 EFA86312.1 - 2.9e-19 68.9 0.5 1.4e-18 66.8 0.5 2.3 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 EFA86312.1 - 4.7e-19 68.8 0.0 4.7e-19 68.8 0.0 5.1 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Peptidase_S8 PF00082.22 EFA86313.1 - 1.7e-05 24.3 2.1 2.6e-05 23.7 0.1 2.0 2 0 0 2 2 2 1 Subtilase family B12D PF06522.11 EFA86316.1 - 6e-05 22.8 0.0 7.2e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit MalF_P2 PF14785.6 EFA86316.1 - 0.0012 18.9 0.0 0.0014 18.7 0.0 1.1 1 0 0 1 1 1 1 Maltose transport system permease protein MalF P2 domain Aminotran_1_2 PF00155.21 EFA86317.1 - 2.8e-79 266.9 0.0 3.2e-79 266.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II 2OG-FeII_Oxy_2 PF13532.6 EFA86318.1 - 1.8e-12 47.9 0.1 1.7e-07 31.7 0.0 2.5 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily DUF5334 PF17268.2 EFA86318.1 - 0.015 15.6 0.1 2.5 8.5 0.0 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5334) ABC_tran PF00005.27 EFA86319.1 - 7.9e-41 139.8 0.2 6.4e-21 75.3 0.0 3.4 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EFA86319.1 - 4.2e-23 82.6 5.4 2.1e-06 27.8 0.2 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFA86319.1 - 2.5e-13 50.0 7.7 4.5e-09 36.1 0.1 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFA86319.1 - 3.6e-08 33.0 0.1 0.0039 16.9 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFA86319.1 - 3.8e-08 33.9 1.7 9.4e-05 22.9 0.1 2.9 3 0 0 3 3 2 2 AAA ATPase domain ATP-synt_ab PF00006.25 EFA86319.1 - 4.2e-07 29.9 0.1 8.1e-05 22.4 0.0 2.7 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.6 EFA86319.1 - 4.3e-07 30.3 0.5 0.0039 17.5 0.2 3.4 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EFA86319.1 - 7.6e-07 29.2 0.0 0.00082 19.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA86319.1 - 1.5e-06 28.2 0.1 0.0073 16.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 EFA86319.1 - 9.7e-06 25.6 0.0 0.057 13.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_30 PF13604.6 EFA86319.1 - 1.3e-05 25.0 0.1 0.016 15.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EFA86319.1 - 2.4e-05 24.2 8.1 0.015 15.1 0.0 3.0 4 0 0 4 4 3 2 AAA ATPase domain AAA_23 PF13476.6 EFA86319.1 - 6.8e-05 23.5 1.8 0.0096 16.4 0.2 3.6 3 1 1 4 4 4 2 AAA domain AAA_24 PF13479.6 EFA86319.1 - 6.8e-05 22.7 0.0 0.5 10.1 0.0 2.6 3 0 0 3 3 2 2 AAA domain PduV-EutP PF10662.9 EFA86319.1 - 9.7e-05 22.1 0.0 0.74 9.6 0.0 2.7 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EFA86319.1 - 0.00025 20.6 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region MeaB PF03308.16 EFA86319.1 - 0.00041 19.4 0.2 0.5 9.3 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 EFA86319.1 - 0.00046 20.2 0.0 0.76 9.8 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFA86319.1 - 0.00068 20.2 0.0 0.73 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFA86319.1 - 0.00069 20.0 0.8 0.44 11.0 0.2 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EFA86319.1 - 0.001 19.3 0.0 1.8 8.8 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EFA86319.1 - 0.0012 19.1 6.1 0.58 10.4 0.0 3.4 4 0 0 4 4 3 2 AAA domain DUF2813 PF11398.8 EFA86319.1 - 0.0014 18.0 0.9 0.55 9.4 0.0 2.6 3 0 0 3 3 2 1 Protein of unknown function (DUF2813) AAA_5 PF07728.14 EFA86319.1 - 0.0018 18.3 0.1 0.48 10.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFA86319.1 - 0.0027 17.3 0.3 1.4 8.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFA86319.1 - 0.0028 16.9 0.0 0.39 9.9 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 EFA86319.1 - 0.003 17.7 0.2 1.7 8.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 EFA86319.1 - 0.0033 16.6 0.2 0.97 8.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) cobW PF02492.19 EFA86319.1 - 0.005 16.5 0.2 4.2 6.9 0.0 2.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 EFA86319.1 - 0.0082 16.0 1.4 0.038 13.8 1.4 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFA86319.1 - 0.0092 15.7 0.1 4.8 6.9 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EFA86319.1 - 0.013 15.4 0.1 2.3 8.1 0.0 2.7 2 0 0 2 2 2 0 NTPase Sigma54_activat PF00158.26 EFA86319.1 - 0.014 15.1 0.0 0.55 9.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EFA86319.1 - 0.014 15.7 0.0 4.1 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase MobB PF03205.14 EFA86319.1 - 0.016 15.1 0.0 4.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.21 EFA86319.1 - 0.022 14.1 0.0 18 4.7 0.0 3.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Bac_DnaA PF00308.18 EFA86319.1 - 0.024 14.5 0.0 0.064 13.1 0.0 1.7 2 0 0 2 2 1 0 Bacterial dnaA protein Dynamin_N PF00350.23 EFA86319.1 - 0.03 14.4 2.1 0.1 12.7 0.0 2.7 3 0 0 3 3 2 0 Dynamin family T2SSE PF00437.20 EFA86319.1 - 0.03 13.4 0.1 4 6.4 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.6 EFA86319.1 - 0.052 13.8 2.8 5.2 7.4 0.0 4.1 5 0 0 5 5 3 0 Putative exonuclease SbcCD, C subunit KAP_NTPase PF07693.14 EFA86319.1 - 0.071 12.3 0.0 0.82 8.9 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain SRP54 PF00448.22 EFA86319.1 - 0.095 12.3 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain FeoB_N PF02421.18 EFA86319.1 - 0.1 12.1 0.0 2.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_27 PF13514.6 EFA86319.1 - 0.11 12.1 4.1 0.75 9.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain PIN7 PF18475.1 EFA86319.1 - 0.15 12.7 0.0 0.41 11.3 0.0 1.7 1 0 0 1 1 1 0 PIN domain Thymidylate_kin PF02223.17 EFA86319.1 - 0.19 11.4 1.5 1.2 8.8 0.0 2.7 3 0 0 3 3 2 0 Thymidylate kinase ABC_ATPase PF09818.9 EFA86319.1 - 0.26 10.0 3.3 6.2 5.5 0.0 2.9 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 EFA86319.1 - 0.51 9.6 4.0 7.3 5.8 0.1 2.7 3 0 0 3 3 2 0 Zeta toxin DUF5039 PF16442.5 EFA86319.1 - 0.95 9.0 8.4 0.62 9.6 6.5 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF5039) ABC_tran_Xtn PF12848.7 EFA86319.1 - 2.2 8.4 11.5 0.32 11.1 6.4 2.0 2 0 0 2 2 2 0 ABC transporter Ank_2 PF12796.7 EFA86320.1 - 1.1e-22 80.4 1.0 5.4e-05 23.7 0.0 5.2 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86320.1 - 4.3e-18 65.4 4.2 0.0023 18.5 0.2 8.1 4 1 6 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA86320.1 - 2.4e-15 56.4 5.0 1.6 9.1 0.0 10.7 5 3 6 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86320.1 - 2.1e-14 52.2 3.8 24 5.9 0.0 11.2 10 2 2 12 12 12 2 Ankyrin repeat RhoGAP PF00620.27 EFA86320.1 - 0.13 12.1 1.3 1.2 9.0 0.4 2.4 2 0 0 2 2 2 0 RhoGAP domain DUF3447 PF11929.8 EFA86320.1 - 0.57 10.2 27.8 0.33 10.9 1.4 6.5 5 3 2 7 7 7 0 Domain of unknown function (DUF3447) PRANC PF09372.10 EFA86320.1 - 4.9 7.6 10.9 0.095 13.0 1.6 2.9 3 0 0 3 3 3 0 PRANC domain OrfB_Zn_ribbon PF07282.11 EFA86321.1 - 1.6e-06 27.9 0.4 0.00032 20.5 0.0 2.6 2 0 0 2 2 2 2 Putative transposase DNA-binding domain Phage_Gp23 PF10669.9 EFA86322.1 - 0.19 12.1 12.1 0.47 10.8 12.1 1.7 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) tRNA_synt_1c_R2 PF04557.15 EFA86322.1 - 0.33 11.9 19.4 0.9 10.5 19.4 1.7 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Connexin PF00029.19 EFA86322.1 - 1 9.0 9.4 1.8 8.2 9.4 1.3 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 EFA86322.1 - 1.2 7.8 12.7 2.2 7.0 12.7 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter HA2 PF04408.23 EFA86322.1 - 1.4 9.2 3.3 3.4 8.0 3.3 1.6 1 0 0 1 1 1 0 Helicase associated domain (HA2) DUF3915 PF13054.6 EFA86322.1 - 2.6 8.1 8.7 7 6.7 8.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM176 PF14851.6 EFA86322.1 - 2.8 7.6 9.9 5.8 6.6 9.9 1.4 1 0 0 1 1 1 0 FAM176 family O-antigen_lig PF13425.6 EFA86322.1 - 4.4 6.0 12.1 7.4 5.2 12.1 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein EIIBC-GUT_N PF03612.14 EFA86322.1 - 9.6 5.9 7.7 19 4.9 7.7 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TTC5_OB PF16669.5 EFA86326.1 - 5.4e-14 51.9 1.5 5.7e-14 51.8 0.1 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_2 PF07719.17 EFA86326.1 - 1.1e-09 37.7 8.1 0.00079 19.4 0.2 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86326.1 - 2.6e-09 36.5 10.9 0.0004 20.1 0.4 6.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86326.1 - 3.6e-06 26.8 9.4 0.032 14.4 0.1 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA86326.1 - 0.0012 19.0 10.9 7.1 7.3 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86326.1 - 0.0044 17.3 2.8 1.2 9.4 0.1 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFA86326.1 - 0.011 16.4 0.0 1.8 9.3 0.0 3.0 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86326.1 - 0.019 15.5 0.4 1.3 9.5 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TOM20_plant PF06552.12 EFA86326.1 - 0.032 14.0 4.0 0.071 12.9 2.0 2.4 1 1 1 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_14 PF13428.6 EFA86326.1 - 0.099 13.5 0.0 10 7.2 0.0 3.3 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFA86326.1 - 0.26 11.0 16.8 0.37 10.5 0.0 5.0 6 1 1 7 7 7 0 TPR repeat TPR_7 PF13176.6 EFA86326.1 - 0.27 11.3 1.5 18 5.7 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Amnionless PF14828.6 EFA86327.1 - 0.00029 19.8 0.5 0.00029 19.8 0.5 2.9 3 1 0 3 3 3 1 Amnionless Cyclin_C_2 PF16899.5 EFA86327.1 - 0.15 12.5 0.0 0.43 11.0 0.0 1.8 1 0 0 1 1 1 0 Cyclin C-terminal domain LSM PF01423.22 EFA86328.1 - 3.5e-06 26.6 0.9 6.5e-06 25.8 0.9 1.6 1 1 0 1 1 1 1 LSM domain DUF3364 PF11844.8 EFA86328.1 - 3.3e-05 24.0 6.2 0.00043 20.5 0.7 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3364) Secretin_N_2 PF07655.13 EFA86328.1 - 0.9 10.1 19.9 0.14 12.7 13.7 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain SET PF00856.28 EFA86329.1 - 1.9e-22 80.4 0.2 1.9e-22 80.4 0.2 4.9 3 2 0 3 3 3 1 SET domain PP-binding PF00550.25 EFA86330.1 - 1.6e-13 50.8 0.1 2.1e-13 50.4 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ribosomal_L50 PF10501.9 EFA86330.1 - 0.0032 17.6 0.1 0.0045 17.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal subunit 39S PP-binding_2 PF14573.6 EFA86330.1 - 0.0057 16.8 0.5 0.0093 16.2 0.5 1.3 1 1 0 1 1 1 1 Acyl-carrier LRR_6 PF13516.6 EFA86331.1 - 2e-12 46.1 6.9 0.0014 18.5 0.0 5.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 EFA86331.1 - 0.096 13.3 2.7 47 5.1 0.0 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat TRAPPC-Trs85 PF12739.7 EFA86331.1 - 1.1 8.2 9.7 0.4 9.6 4.4 2.4 2 0 0 2 2 2 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF4286 PF14114.6 EFA86332.1 - 0.098 13.2 1.4 0.23 12.0 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) SR-25 PF10500.9 EFA86332.1 - 4.5 6.8 10.8 0.48 10.0 5.0 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Thg1 PF04446.12 EFA86333.1 - 3.6e-51 172.4 0.2 7.4e-51 171.4 0.2 1.6 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EFA86333.1 - 2.7e-44 150.2 1.3 8.7e-44 148.6 1.3 1.8 2 0 0 2 2 2 1 Thg1 C terminal domain Pkinase PF00069.25 EFA86333.1 - 1.8e-25 89.8 0.1 6.6e-25 88.0 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86333.1 - 1.6e-07 30.9 0.0 3.3e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Glyco_hydro_9 PF00759.19 EFA86334.1 - 7.2e-109 364.9 8.7 9.1e-109 364.6 8.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Cytochrom_C_asm PF01578.20 EFA86334.1 - 0.084 12.6 0.7 0.18 11.5 0.1 1.9 2 0 0 2 2 2 0 Cytochrome C assembly protein BACK PF07707.15 EFA86335.1 - 6.2e-06 26.2 0.6 0.0025 17.9 0.2 2.6 2 1 0 2 2 2 2 BTB And C-terminal Kelch adh_short PF00106.25 EFA86336.1 - 2.3e-26 92.5 0.0 1.5e-20 73.5 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86336.1 - 5.4e-11 42.5 0.0 6.2e-09 35.8 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA86336.1 - 7.8e-09 35.7 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EFA86336.1 - 0.038 14.3 0.0 0.072 13.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFA86336.1 - 0.062 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FliW PF02623.15 EFA86336.1 - 0.11 12.5 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 FliW protein Mitofilin PF09731.9 EFA86337.1 - 5.5e-14 52.0 0.1 5.5e-14 52.0 0.1 3.2 1 1 1 2 2 2 1 Mitochondrial inner membrane protein DXP_redisom_C PF08436.12 EFA86337.1 - 0.032 14.4 0.0 0.095 12.9 0.0 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain DUF357 PF04010.13 EFA86337.1 - 0.18 11.9 0.6 3 8.0 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF357) PHD PF00628.29 EFA86338.1 - 0.074 12.9 1.7 0.19 11.7 1.7 1.7 1 0 0 1 1 1 0 PHD-finger ubiquitin PF00240.23 EFA86339.1 - 1.1e-06 28.3 0.4 1.5e-06 27.9 0.4 1.4 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EFA86339.1 - 0.00026 21.4 0.1 0.00029 21.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFA86339.1 - 0.0073 16.3 0.4 0.047 13.7 0.4 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 EFA86339.1 - 0.029 14.2 0.0 0.051 13.4 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TIG PF01833.24 EFA86340.1 - 8.6e-22 77.0 61.7 3.5e-09 36.6 6.4 8.3 8 0 0 8 8 8 6 IPT/TIG domain EGF_2 PF07974.13 EFA86340.1 - 6.9e-07 29.5 40.1 0.00011 22.5 11.1 3.1 3 0 0 3 3 3 2 EGF-like domain EGF_Tenascin PF18720.1 EFA86340.1 - 5.6e-05 23.1 6.2 5.6e-05 23.1 6.2 2.8 2 0 0 2 2 2 1 Tenascin EGF domain Laminin_EGF PF00053.24 EFA86340.1 - 0.013 15.6 21.6 0.081 13.1 7.3 2.7 2 0 0 2 2 2 0 Laminin EGF domain EAV_GP5 PF15981.5 EFA86340.1 - 0.029 14.8 1.3 0.092 13.2 1.3 1.9 1 0 0 1 1 1 0 Envelope glycoprotein GP 5 of equine arteritis virus EGF PF00008.27 EFA86340.1 - 0.034 14.5 33.2 0.029 14.7 7.7 3.1 3 0 0 3 3 3 0 EGF-like domain DUF1325 PF07039.11 EFA86340.1 - 0.068 13.2 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 SGF29 tudor-like domain UPF0179 PF03684.13 EFA86340.1 - 0.75 9.7 7.8 0.14 12.1 2.6 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0179) hEGF PF12661.7 EFA86340.1 - 9.4 7.0 19.8 14 6.5 7.5 3.0 2 0 0 2 2 2 0 Human growth factor-like EGF ubiquitin PF00240.23 EFA86341.1 - 2.6e-05 23.9 0.7 4e-05 23.3 0.7 1.4 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EFA86341.1 - 5.7e-05 23.5 0.2 7e-05 23.2 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 EFA86341.1 - 0.0073 16.1 0.1 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFA86341.1 - 0.026 14.5 0.8 0.29 11.2 0.3 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain DDE_Tnp_4 PF13359.6 EFA86342.1 - 6.1e-16 58.5 0.0 9.1e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EFA86342.1 - 0.00069 19.3 0.0 0.00098 18.8 0.0 1.2 1 0 0 1 1 1 1 Transposase DDE domain Histone PF00125.24 EFA86343.1 - 4.5e-11 43.2 0.9 7.8e-06 26.3 1.1 2.3 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFA86343.1 - 2.1e-07 31.1 2.6 0.0033 17.7 0.5 2.8 3 0 0 3 3 3 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFA86344.1 - 6.1e-27 94.6 18.7 1.2e-06 28.9 0.5 4.2 4 0 0 4 4 4 4 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFA86344.1 - 5.1e-11 42.7 15.0 0.0086 16.3 0.4 4.3 4 0 0 4 4 4 4 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone_H2A_C PF16211.5 EFA86344.1 - 1.7e-05 24.4 0.0 4.6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 C-terminus of histone H2A DUF740 PF05340.12 EFA86344.1 - 0.061 12.1 0.0 4.6 5.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF740) Ribosomal_L30_N PF08079.12 EFA86344.1 - 6.5 7.1 6.1 36 4.7 0.6 2.5 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain Peptidase_C97 PF05903.14 EFA86345.1 - 0.0046 16.8 0.0 0.0062 16.4 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain SmaI PF17411.2 EFA86345.1 - 0.03 13.5 0.0 0.04 13.1 0.0 1.1 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease RabGAP-TBC PF00566.18 EFA86347.1 - 1.7e-28 99.7 5.0 1.7e-28 99.7 5.0 3.4 2 1 2 4 4 4 2 Rab-GTPase-TBC domain Lactamase_B PF00753.27 EFA86349.1 - 1.2e-09 38.5 0.0 3.3e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EFA86349.1 - 9.1e-09 35.2 0.2 1.6e-08 34.3 0.2 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EFA86349.1 - 8.3e-06 25.5 0.1 1.5e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Tup_N PF08581.10 EFA86350.1 - 0.017 15.4 0.2 0.029 14.7 0.2 1.4 1 0 0 1 1 1 0 Tup N-terminal DUF4838 PF16126.5 EFA86350.1 - 0.054 12.9 0.1 0.067 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) F_actin_bind PF08919.10 EFA86350.1 - 0.07 13.2 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 F-actin binding WD40 PF00400.32 EFA86351.1 - 2e-24 85.4 0.7 4.7e-05 24.1 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat LisH_TPL PF17814.1 EFA86351.1 - 4.6e-13 48.6 0.1 9.3e-13 47.6 0.1 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 EFA86351.1 - 4.1e-11 43.0 0.2 0.044 14.1 0.0 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA86351.1 - 0.00017 20.4 1.1 0.092 11.4 0.5 3.0 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFA86351.1 - 0.00082 18.4 1.6 0.84 8.5 0.0 2.7 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein TRAPP PF04051.16 EFA86351.1 - 0.0071 16.1 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PHTB1_N PF14727.6 EFA86351.1 - 0.017 14.5 0.0 0.19 11.0 0.0 2.3 1 1 1 2 2 2 0 PTHB1 N-terminus Ribosomal_L26 PF16906.5 EFA86352.1 - 2.3e-36 124.1 4.1 3.4e-36 123.6 4.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EFA86352.1 - 2.8e-06 27.1 2.6 3.5e-06 26.8 1.3 1.9 2 0 0 2 2 2 1 KOW motif Methyltrans_RNA PF04452.14 EFA86352.1 - 0.015 14.6 0.2 0.019 14.3 0.2 1.2 1 0 0 1 1 1 0 RNA methyltransferase Urm1 PF09138.11 EFA86353.1 - 1.8e-34 118.0 0.1 2e-34 117.8 0.1 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EFA86353.1 - 0.00026 21.6 0.0 0.00031 21.3 0.0 1.2 1 0 0 1 1 1 1 ThiS family DUF2093 PF09866.9 EFA86353.1 - 0.05 13.1 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2093) DnaJ PF00226.31 EFA86354.1 - 3.3e-06 27.1 0.0 5.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 EFA86354.1 - 3.6e-05 23.8 0.1 4.1e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Pam16 Mito_carr PF00153.27 EFA86355.1 - 3.2e-65 216.1 4.6 1.1e-23 83.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Rad52_Rad22 PF04098.15 EFA86356.1 - 7.9e-07 29.1 0.3 3.1e-06 27.2 0.0 1.8 1 1 1 2 2 2 1 Rad52/22 family double-strand break repair protein RRM_1 PF00076.22 EFA86356.1 - 0.00012 21.9 0.0 0.0002 21.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFA86356.1 - 0.00016 21.3 0.0 0.0004 20.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TrmE_N PF10396.9 EFA86356.1 - 0.12 12.7 0.1 0.27 11.6 0.1 1.6 1 0 0 1 1 1 0 GTP-binding protein TrmE N-terminus Hamartin PF04388.12 EFA86357.1 - 7.6e-05 21.6 29.2 7.6e-05 21.6 29.2 2.1 2 0 0 2 2 2 2 Hamartin protein TFIIA PF03153.13 EFA86357.1 - 4.8 7.1 40.7 0.27 11.2 13.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Beach PF02138.18 EFA86358.1 - 5.7e-88 294.9 0.3 5.7e-88 294.9 0.3 2.6 2 0 0 2 2 2 1 Beige/BEACH domain DUF4704 PF15787.5 EFA86358.1 - 1.1e-17 64.2 20.0 3.4e-13 49.5 6.4 3.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4704) PH_BEACH PF14844.6 EFA86358.1 - 5.3e-13 48.9 3.2 1e-12 48.0 0.0 3.2 3 0 0 3 3 3 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EFA86358.1 - 6.7e-07 29.9 2.4 0.00042 21.1 0.4 3.3 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF1088 PF06469.11 EFA86358.1 - 0.18 11.5 5.5 0.094 12.4 2.5 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1088) Spt20 PF12090.8 EFA86360.1 - 0.00052 19.7 14.6 0.00076 19.2 14.6 1.3 1 0 0 1 1 1 1 Spt20 family Coa1 PF08695.10 EFA86360.1 - 0.0019 17.9 0.0 0.062 13.0 0.0 2.3 2 0 0 2 2 2 1 Cytochrome oxidase complex assembly protein 1 DUF2828 PF11443.8 EFA86360.1 - 0.0081 14.3 6.5 0.01 14.0 6.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Presenilin PF01080.17 EFA86360.1 - 0.016 14.0 9.3 0.019 13.7 9.3 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EFA86360.1 - 0.027 12.8 7.7 0.035 12.4 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 EFA86360.1 - 0.067 13.3 3.8 0.08 13.1 3.8 1.2 1 0 0 1 1 1 0 DDHD domain DUF3043 PF11241.8 EFA86360.1 - 0.29 11.2 1.1 0.39 10.7 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Hydin_ADK PF17213.3 EFA86360.1 - 0.53 10.5 4.3 0.73 10.1 4.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RP-C_C PF11800.8 EFA86360.1 - 0.94 9.5 6.2 1.3 9.1 6.2 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region PTPRCAP PF15713.5 EFA86360.1 - 1.1 9.5 15.7 1.8 8.8 15.7 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RGS-like PF09128.11 EFA86360.1 - 1.5 8.5 9.9 2.5 7.8 9.9 1.3 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain RR_TM4-6 PF06459.12 EFA86360.1 - 4.3 7.1 16.3 6.3 6.5 16.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3438 PF11920.8 EFA86360.1 - 7 5.8 9.6 10 5.3 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) ALMT PF11744.8 EFA86360.1 - 8.3 5.1 9.3 12 4.6 9.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 EFA86360.1 - 9.7 4.2 17.0 12 3.9 17.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CBF PF03914.17 EFA86361.1 - 5.2e-40 137.2 0.7 5.2e-40 137.2 0.7 2.8 3 0 0 3 3 3 1 CBF/Mak21 family Tim54 PF11711.8 EFA86361.1 - 0.016 14.0 16.3 0.14 10.9 3.7 2.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MID_MedPIWI PF18296.1 EFA86361.1 - 0.51 10.1 14.6 0.4 10.4 1.1 2.8 2 0 0 2 2 2 0 MID domain of medPIWI Dsh_C PF12316.8 EFA86361.1 - 2.8 8.3 7.4 1.8 8.9 0.4 2.4 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal DUF5308 PF17233.2 EFA86361.1 - 5.9 7.1 7.6 3 8.1 0.5 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Ecm29 PF13001.7 EFA86362.1 - 1.8e-128 429.4 6.3 1.8e-128 429.4 6.3 5.8 5 1 1 6 6 6 2 Proteasome stabiliser Vac14_Fab1_bd PF12755.7 EFA86362.1 - 3.6e-07 30.7 1.8 0.0021 18.6 0.0 6.8 6 1 1 7 7 7 1 Vacuolar 14 Fab1-binding region Anticodon_1 PF08264.13 EFA86362.1 - 0.0034 17.4 1.8 0.1 12.5 0.0 3.8 4 0 0 4 4 4 1 Anticodon-binding domain of tRNA HEAT PF02985.22 EFA86362.1 - 0.053 13.8 0.1 32 5.2 0.0 5.6 7 0 0 7 7 7 0 HEAT repeat RSS_P20 PF11757.8 EFA86362.1 - 0.1 13.1 1.3 5.3 7.6 0.1 4.2 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain Erf4 PF10256.9 EFA86362.1 - 0.12 12.5 5.1 6.4 6.9 0.1 4.9 3 1 1 4 4 4 0 Golgin subfamily A member 7/ERF4 family RNA_pol_Rpb4 PF03874.16 EFA86362.1 - 0.24 11.7 3.6 1.6 9.1 0.1 3.8 3 1 0 3 3 3 0 RNA polymerase Rpb4 Xpo1 PF08389.12 EFA86362.1 - 0.26 11.3 8.9 0.22 11.6 0.7 4.8 3 0 0 3 3 3 0 Exportin 1-like protein PepSY_like PF11396.8 EFA86363.1 - 0.025 15.1 2.0 0.03 14.8 0.3 1.9 2 0 0 2 2 2 0 Putative beta-lactamase-inhibitor-like, PepSY-like ERCC4 PF02732.15 EFA86364.1 - 3.3e-15 56.6 0.0 3.3e-15 56.6 0.0 3.0 2 1 1 3 3 3 1 ERCC4 domain SAM_1 PF00536.30 EFA86364.1 - 3.3e-07 30.6 0.0 8.4e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA86364.1 - 3.7e-05 23.7 0.0 0.00011 22.2 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HTH_45 PF14947.6 EFA86364.1 - 0.018 15.0 0.4 0.12 12.3 0.1 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix Glyco_hydro_18 PF00704.28 EFA86365.1 - 2.5e-26 93.2 0.3 1e-25 91.1 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 P3A PF08727.11 EFA86365.1 - 0.22 10.9 0.4 1.8 8.0 0.0 2.5 3 0 0 3 3 3 0 Poliovirus 3A protein like ABC_tran PF00005.27 EFA86366.1 - 1.2e-33 116.5 0.1 6.5e-33 114.1 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EFA86366.1 - 8e-30 104.4 16.4 1.1e-29 104.0 16.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EFA86366.1 - 2e-07 30.6 0.2 1.6e-06 27.7 0.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DEAD PF00270.29 EFA86366.1 - 0.0012 18.7 0.1 0.0049 16.7 0.1 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF87 PF01935.17 EFA86366.1 - 0.0048 17.0 0.0 0.016 15.3 0.0 1.9 1 0 0 1 1 1 1 Helicase HerA, central domain UPF0227 PF05728.12 EFA86366.1 - 0.017 15.1 0.1 0.037 14.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) AAA_22 PF13401.6 EFA86366.1 - 0.018 15.3 2.1 0.17 12.2 0.4 2.9 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFA86366.1 - 0.02 15.0 0.1 0.047 13.8 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA86366.1 - 0.022 14.6 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 EFA86366.1 - 0.029 14.9 0.1 0.029 14.9 0.1 2.4 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EFA86366.1 - 0.045 13.5 0.1 0.17 11.7 0.1 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sod_Ni PF09055.11 EFA86366.1 - 0.086 13.4 0.4 0.24 12.0 0.4 1.7 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase Gti1_Pac2 PF09729.9 EFA86367.1 - 0.21 11.7 8.8 1.8 8.6 1.0 2.7 2 0 0 2 2 2 0 Gti1/Pac2 family POX PF07526.11 EFA86367.1 - 1.4 9.5 5.1 22 5.6 1.3 2.5 2 0 0 2 2 2 0 Associated with HOX DUF4834 PF16118.5 EFA86367.1 - 2.3 9.2 10.6 11 7.1 1.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) zf-B_box PF00643.24 EFA86368.1 - 0.026 14.7 6.3 0.05 13.8 6.3 1.4 1 0 0 1 1 1 0 B-box zinc finger Mucin PF01456.17 EFA86369.1 - 0.0016 18.4 12.8 0.0016 18.4 12.8 2.2 2 0 0 2 2 2 1 Mucin-like glycoprotein BUD22 PF09073.10 EFA86369.1 - 0.11 11.8 0.9 0.16 11.3 0.9 1.3 1 0 0 1 1 1 0 BUD22 AJAP1_PANP_C PF15298.6 EFA86369.1 - 0.35 11.1 12.4 0.078 13.2 6.3 2.4 3 0 0 3 3 3 0 AJAP1/PANP C-terminus MGC-24 PF05283.11 EFA86369.1 - 7.4 7.0 12.9 7.1 7.1 9.7 2.2 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Lipase_3 PF01764.25 EFA86370.1 - 2.3e-21 76.1 0.0 2e-20 73.1 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) CBM49 PF09478.10 EFA86370.1 - 3.1e-05 24.2 1.3 9.4e-05 22.7 1.3 1.9 1 1 0 1 1 1 1 Carbohydrate binding domain CBM49 LRR_9 PF14580.6 EFA86371.1 - 2.1e-16 59.9 18.0 1.4e-12 47.4 7.7 4.6 2 1 3 5 5 5 2 Leucine-rich repeat LRR_8 PF13855.6 EFA86371.1 - 2.3e-16 59.3 33.7 3.3e-06 26.7 4.8 5.4 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFA86371.1 - 1.1e-15 57.5 38.5 2e-05 24.9 3.4 6.8 2 1 7 9 9 9 8 Leucine Rich repeats (2 copies) Lactamase_B_2 PF12706.7 EFA86371.1 - 0.12 11.8 0.0 2 7.9 0.0 2.2 2 0 0 2 2 2 0 Beta-lactamase superfamily domain LRR_1 PF00560.33 EFA86371.1 - 0.82 10.5 20.0 8.9 7.3 0.0 8.1 8 1 0 8 8 8 0 Leucine Rich Repeat LRR_6 PF13516.6 EFA86371.1 - 4.8 7.5 33.5 12 6.2 0.3 8.5 8 0 0 8 8 8 0 Leucine Rich repeat VDE PF07137.11 EFA86372.1 - 0.0065 16.0 0.9 0.007 15.9 0.9 1.0 1 0 0 1 1 1 1 VDE lipocalin domain Glyco_hydro_18 PF00704.28 EFA86373.1 - 1e-11 45.1 0.0 2.4e-11 43.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 HSP70 PF00012.20 EFA86375.1 - 9e-262 869.6 9.4 1.2e-261 869.2 9.1 1.3 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EFA86375.1 - 3.3e-15 55.7 0.2 1e-13 50.8 0.1 2.3 2 0 0 2 2 2 1 MreB/Mbl protein Fe-S_biosyn PF01521.20 EFA86375.1 - 1.7e-13 50.7 0.9 2.4e-12 47.0 0.5 2.6 2 0 0 2 2 2 1 Iron-sulphur cluster biosynthesis FGGY_C PF02782.16 EFA86375.1 - 0.0022 17.7 0.0 0.0054 16.5 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 EFA86375.1 - 0.019 14.2 0.3 0.66 9.2 0.0 2.4 2 0 0 2 2 2 0 StbA protein Hydantoinase_A PF01968.18 EFA86375.1 - 0.036 13.3 2.0 0.08 12.2 0.1 2.5 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase RRM_1 PF00076.22 EFA86376.1 - 2.1e-84 277.3 6.5 6.3e-23 80.4 0.4 5.1 4 1 1 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EFA86376.1 - 1.2e-19 70.2 0.2 1.3e-18 67.0 0.1 2.4 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EFA86376.1 - 6.5e-10 38.7 0.1 0.0076 15.8 0.0 3.9 1 1 3 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 EFA86376.1 - 1.2e-09 38.0 0.1 0.0015 18.5 0.1 4.1 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFA86376.1 - 9.2e-08 31.8 0.4 0.036 13.9 0.1 4.5 4 2 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFA86376.1 - 1.2e-06 28.4 0.2 1 9.4 0.0 3.9 4 0 0 4 4 4 3 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFA86376.1 - 2.5e-06 27.5 0.2 7.7 6.7 0.0 5.0 4 2 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.11 EFA86376.1 - 1.3e-05 25.2 2.1 1.2 9.2 0.2 4.5 3 1 1 4 4 4 1 RNA binding motif SET_assoc PF11767.8 EFA86376.1 - 0.0041 16.7 1.7 7.8 6.2 0.0 4.7 4 1 1 5 5 5 1 Histone lysine methyltransferase SET associated OB_RNB PF08206.11 EFA86376.1 - 0.026 14.2 3.6 2.7 7.8 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain Tex_YqgF PF16921.5 EFA86376.1 - 0.063 13.7 0.5 0.15 12.5 0.1 1.9 2 0 0 2 2 2 0 Tex protein YqgF-like domain DUF4523 PF15023.6 EFA86376.1 - 0.076 12.8 0.1 1.6 8.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) FANC_SAP PF18081.1 EFA86376.1 - 0.11 12.7 2.4 0.18 12.0 0.6 2.2 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain DbpA PF03880.15 EFA86376.1 - 0.12 12.4 0.0 5.7 7.0 0.0 2.8 2 0 0 2 2 2 0 DbpA RNA binding domain RNA12 PF10443.9 EFA86377.1 - 4.4e-12 45.5 0.4 1.1e-08 34.2 0.5 2.5 2 0 0 2 2 2 2 RNA12 protein RRM_1 PF00076.22 EFA86377.1 - 1.7e-05 24.6 0.0 5e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 EFA86377.1 - 0.00018 21.5 3.7 0.00021 21.3 0.0 2.9 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFA86377.1 - 0.0023 18.2 0.0 0.008 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFA86377.1 - 0.0054 17.2 0.5 0.059 13.8 0.0 3.0 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_theta PF06440.11 EFA86377.1 - 0.0066 16.1 0.2 0.029 14.0 0.2 2.1 1 0 0 1 1 1 1 DNA polymerase III, theta subunit She9_MDM33 PF05546.11 EFA86377.1 - 0.039 13.7 0.3 0.039 13.7 0.3 2.7 3 0 0 3 3 3 0 She9 / Mdm33 family AAA_7 PF12775.7 EFA86377.1 - 0.048 13.2 0.0 0.46 10.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 EFA86377.1 - 0.059 13.9 1.6 0.93 10.0 0.0 3.2 3 0 0 3 3 3 0 ABC transporter Androgen_recep PF02166.16 EFA86377.1 - 0.14 10.9 1.2 0.21 10.4 1.2 1.1 1 0 0 1 1 1 0 Androgen receptor AAA_18 PF13238.6 EFA86377.1 - 0.17 12.4 0.0 0.17 12.4 0.0 2.7 3 1 1 4 4 4 0 AAA domain AI-2E_transport PF01594.16 EFA86377.1 - 0.18 10.9 1.6 0.36 9.9 1.6 1.4 1 0 0 1 1 1 0 AI-2E family transporter AAA_33 PF13671.6 EFA86377.1 - 0.21 11.7 0.5 0.84 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain TINF2_N PF14973.6 EFA86377.1 - 6.4 7.1 15.0 0.11 12.9 0.5 3.7 4 0 0 4 4 4 0 TERF1-interacting nuclear factor 2 N-terminus eIF3_N PF09440.10 EFA86378.1 - 4.5e-20 72.4 5.4 3.9e-18 66.2 0.5 2.8 2 1 1 3 3 2 2 eIF3 subunit 6 N terminal domain PCI PF01399.27 EFA86378.1 - 3.2e-12 46.9 1.0 8.5e-12 45.5 0.3 2.1 2 0 0 2 2 2 1 PCI domain TPR_16 PF13432.6 EFA86378.1 - 0.0052 17.4 1.9 0.069 13.8 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-C4H2 PF10146.9 EFA86378.1 - 0.0066 16.8 0.5 0.0066 16.8 0.5 2.3 2 0 0 2 2 2 1 Zinc finger-containing protein TPR_3 PF07720.12 EFA86378.1 - 0.0086 16.1 0.3 0.037 14.0 0.3 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA86378.1 - 0.012 16.2 0.5 0.069 13.8 0.5 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86378.1 - 0.026 14.6 1.8 0.074 13.2 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ThiJ_like PF17124.5 EFA86378.1 - 0.03 14.0 0.3 0.059 13.1 0.3 1.6 1 0 0 1 1 1 0 ThiJ/PfpI family-like TPR_8 PF13181.6 EFA86378.1 - 0.044 14.0 0.4 0.044 14.0 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3050 PF11251.8 EFA86378.1 - 0.12 11.9 2.2 0.16 11.6 0.8 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3050) Osmo_CC PF08946.10 EFA86378.1 - 0.13 12.5 0.7 0.82 10.0 0.2 2.5 2 0 0 2 2 2 0 Osmosensory transporter coiled coil ANAPC3 PF12895.7 EFA86378.1 - 0.19 12.0 0.1 0.19 12.0 0.1 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFA86378.1 - 0.38 11.7 0.0 0.38 11.7 0.0 3.1 3 1 1 4 4 2 0 Tetratricopeptide repeat IHABP4_N PF16174.5 EFA86378.1 - 0.56 10.8 12.7 1.4 9.5 2.6 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal UBN_AB PF14075.6 EFA86378.1 - 0.75 9.5 6.3 0.11 12.2 0.8 2.1 2 0 0 2 2 2 0 Ubinuclein conserved middle domain DUF4598 PF15370.6 EFA86378.1 - 1.1 9.7 3.8 0.54 10.7 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4598) Mucin PF01456.17 EFA86378.1 - 1.2 9.1 26.8 0.29 11.1 12.6 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein SKA1 PF07160.12 EFA86378.1 - 1.7 8.4 10.6 0.22 11.4 3.0 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF2057 PF09829.9 EFA86378.1 - 2.2 8.4 15.4 2.3 8.3 4.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF4179 PF13786.6 EFA86378.1 - 4.5 7.8 6.4 0.58 10.7 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) FSA_C PF10479.9 EFA86378.1 - 6 4.9 9.5 0.4 8.8 1.2 2.1 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus ATG16 PF08614.11 EFA86378.1 - 7.5 6.7 17.4 2.1 8.5 3.4 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) P16-Arc PF04699.14 EFA86379.1 - 0.097 13.2 3.2 0.13 12.8 3.2 1.3 1 1 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Arf PF00025.21 EFA86380.1 - 2.6e-56 189.8 0.3 3.2e-56 189.5 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFA86380.1 - 1e-12 47.9 0.3 1.2e-12 47.6 0.3 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFA86380.1 - 1.7e-09 37.9 0.0 2.5e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA86380.1 - 2.4e-09 37.0 0.0 2.9e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFA86380.1 - 5.9e-09 35.5 2.2 2.4e-05 23.7 0.2 2.5 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFA86380.1 - 3.8e-06 26.9 0.2 6.1e-06 26.3 0.2 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFA86380.1 - 0.084 12.9 0.1 0.21 11.6 0.1 1.6 1 1 0 1 1 1 0 Dynamin family adh_short PF00106.25 EFA86381.1 - 1.8e-27 96.1 0.0 8.9e-22 77.5 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86381.1 - 5.2e-12 45.8 0.0 5.9e-10 39.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA86381.1 - 1.7e-09 37.8 0.0 2.7e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EFA86381.1 - 0.0076 16.5 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFA86381.1 - 0.049 13.7 0.0 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FliW PF02623.15 EFA86381.1 - 0.097 12.6 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 FliW protein B_lectin PF01453.24 EFA86382.1 - 3.4e-17 62.9 0.6 8.2e-05 23.1 0.0 4.1 2 2 2 4 4 4 4 D-mannose binding lectin BofC_C PF08955.10 EFA86382.1 - 0.053 13.6 0.3 2.6 8.1 0.0 2.7 3 0 0 3 3 3 0 BofC C-terminal domain AbrB-like PF14250.6 EFA86382.1 - 0.21 11.7 4.2 14 5.8 0.0 4.5 3 2 2 5 5 5 0 AbrB-like transcriptional regulator Ly49 PF08391.10 EFA86383.1 - 0.73 10.2 5.6 1.2 9.5 5.6 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region FAM199X PF15814.5 EFA86383.1 - 0.81 8.7 5.7 1.3 8.0 5.7 1.2 1 0 0 1 1 1 0 Protein family FAM199X Sporozoite_P67 PF05642.11 EFA86383.1 - 1.7 6.7 12.4 2.9 5.9 12.4 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RP-C_C PF11800.8 EFA86383.1 - 2.3 8.3 5.9 18 5.3 0.2 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region CPSF100_C PF13299.6 EFA86383.1 - 5.7 7.1 8.2 1.6 8.9 0.5 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Foie-gras_1 PF11817.8 EFA86384.1 - 0.13 11.8 0.4 0.14 11.7 0.4 1.2 1 0 0 1 1 1 0 Foie gras liver health family 1 DAO PF01266.24 EFA86385.1 - 3.7e-37 128.7 0.0 4.4e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFA86385.1 - 0.014 14.6 0.0 0.028 13.6 0.0 1.5 1 0 0 1 1 1 0 Thi4 family AAA_23 PF13476.6 EFA86386.1 - 1.4e-17 64.9 53.3 4.6e-11 43.6 47.6 4.3 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 EFA86386.1 - 1.5e-10 40.9 22.0 1.3e-06 28.1 0.2 3.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA86386.1 - 4e-06 26.8 5.2 0.00045 20.1 0.0 3.7 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Metallophos PF00149.28 EFA86386.1 - 1.6e-05 25.5 0.1 3.4e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_29 PF13555.6 EFA86386.1 - 9.4e-05 22.1 0.1 0.00021 21.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Metallophos_2 PF12850.7 EFA86386.1 - 0.00041 20.6 0.1 0.0013 19.0 0.1 1.9 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AAA_18 PF13238.6 EFA86386.1 - 0.08 13.5 1.6 0.49 10.9 0.0 3.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFA86386.1 - 0.092 13.3 14.0 5.8 7.4 5.0 4.6 3 1 0 3 3 3 0 ABC transporter Pox_A_type_inc PF04508.12 EFA86386.1 - 3.6 7.6 9.7 14 5.7 3.0 3.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Pkinase PF00069.25 EFA86387.1 - 2e-70 237.2 0.0 4.3e-70 236.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86387.1 - 1.2e-31 110.0 0.1 2.6e-31 108.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFA86387.1 - 1.8e-11 43.9 0.0 4e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EFA86387.1 - 0.00021 20.9 0.4 0.00021 20.9 0.4 1.9 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.14 EFA86387.1 - 0.00058 19.3 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFA86387.1 - 0.00068 19.3 0.2 0.0019 17.9 0.2 1.7 1 0 0 1 1 1 1 RIO1 family T6SS_HCP PF05638.12 EFA86388.1 - 1.5e-08 35.1 0.0 3e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp T6SS_HCP PF05638.12 EFA86389.1 - 4.1e-08 33.7 0.0 7.3e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp ubiquitin PF00240.23 EFA86389.1 - 0.059 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family WD40 PF00400.32 EFA86391.1 - 1e-38 130.6 10.4 1.6e-08 35.0 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA86391.1 - 2.2e-06 27.9 2.1 1.4 9.3 0.0 5.6 1 1 6 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA86391.1 - 0.00013 21.4 0.0 1.5 8.1 0.0 3.4 2 1 1 3 3 3 2 WD40-like domain W_rich_C PF07483.11 EFA86391.1 - 0.013 15.7 0.4 0.88 9.8 0.1 3.3 3 0 0 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain Nup160 PF11715.8 EFA86391.1 - 0.03 13.0 4.5 3.3 6.2 0.1 3.9 2 1 0 4 4 4 0 Nucleoporin Nup120/160 ERG4_ERG24 PF01222.17 EFA86393.1 - 6.3e-130 433.8 18.8 7.5e-130 433.5 18.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family TMEM252 PF15664.5 EFA86393.1 - 0.18 11.5 0.4 20 4.9 0.1 2.7 2 0 0 2 2 2 0 Transmembrane protein 252 family Ank_2 PF12796.7 EFA86394.1 - 0.16 12.5 0.0 0.17 12.5 0.0 1.2 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) LRR_4 PF12799.7 EFA86396.1 - 2.4 8.7 15.8 0.19 12.2 2.5 5.1 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) T6SS_HCP PF05638.12 EFA86397.1 - 8.9e-08 32.6 0.0 1.6e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp 4HBT PF03061.22 EFA86398.1 - 3.8e-05 23.9 0.0 5.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EFA86398.1 - 0.00098 19.3 0.1 0.0013 18.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT PF03061.22 EFA86399.1 - 4.6e-10 39.7 0.0 6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EFA86399.1 - 0.048 13.8 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) 4HBT PF03061.22 EFA86400.1 - 3.9e-09 36.7 0.0 4.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Thioesterase superfamily YscK PF06578.12 EFA86400.1 - 0.039 13.5 0.0 0.054 13.0 0.0 1.2 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) DAGK_cat PF00781.24 EFA86401.1 - 1.7e-30 105.2 0.4 3.7e-30 104.1 0.0 1.8 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Cluap1 PF10234.9 EFA86401.1 - 0.0095 15.4 1.0 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Clusterin-associated protein-1 NAD_kinase PF01513.21 EFA86401.1 - 0.072 12.3 0.3 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 ATP-NAD kinase DUF3456 PF11938.8 EFA86401.1 - 1.5 9.3 7.3 0.17 12.4 0.4 2.6 3 0 0 3 3 3 0 TLR4 regulator and MIR-interacting MSAP NPR3 PF03666.13 EFA86403.1 - 2.8e-57 194.6 28.0 2.5e-35 122.2 16.1 3.0 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 EFA86403.1 - 0.0024 16.5 22.8 0.0024 16.5 22.8 1.4 2 0 0 2 2 2 1 Macoilin family DnaJ PF00226.31 EFA86404.1 - 2e-17 63.0 1.8 1.9e-16 59.9 0.2 2.8 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 EFA86404.1 - 0.006 16.4 0.1 0.16 11.8 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Poty_coat PF00767.18 EFA86405.1 - 0.25 10.9 0.1 0.29 10.7 0.1 1.1 1 0 0 1 1 1 0 Potyvirus coat protein HA2 PF04408.23 EFA86406.1 - 3e-27 95.0 0.1 3e-27 95.0 0.1 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA86406.1 - 1.1e-23 83.4 0.0 2.5e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 EFA86406.1 - 1.6e-13 50.8 3.1 3.7e-13 49.6 3.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.31 EFA86406.1 - 2.4e-12 47.2 0.0 5.5e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA86406.1 - 2.6e-06 27.3 0.0 1.1e-05 25.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA86406.1 - 1.5e-05 25.3 0.0 5.8e-05 23.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA86406.1 - 0.002 17.9 0.0 0.0048 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EFA86406.1 - 0.004 17.1 0.0 0.0083 16.1 0.0 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 EFA86406.1 - 0.012 15.9 0.0 0.033 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFA86406.1 - 0.013 14.6 0.3 0.05 12.6 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein Dicty_REP PF05086.12 EFA86406.1 - 0.07 11.1 11.0 0.11 10.5 11.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 EFA86406.1 - 1.7 7.4 4.2 3.2 6.4 4.2 1.4 1 0 0 1 1 1 0 Presenilin eIF_4EBP PF05456.11 EFA86407.1 - 4.4e-19 68.5 16.3 4.7e-18 65.2 16.3 2.0 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Nucleo_P87 PF07267.11 EFA86407.1 - 4.1 6.1 9.4 4.8 5.9 9.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 GTP_EFTU PF00009.27 EFA86408.1 - 2.2e-23 82.8 0.2 4.5e-23 81.8 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFA86408.1 - 1.8e-07 31.4 0.6 1.8e-07 31.4 0.6 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFA86408.1 - 0.001 19.2 0.1 0.0036 17.4 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AlbA_2 PF04326.14 EFA86408.1 - 0.068 13.5 0.1 0.47 10.8 0.0 2.4 2 0 0 2 2 2 0 Putative DNA-binding domain PduV-EutP PF10662.9 EFA86408.1 - 0.074 12.8 0.2 41 3.9 0.0 3.4 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ImcF-related_N PF14331.6 EFA86408.1 - 0.15 11.4 0.0 0.31 10.3 0.0 1.5 1 0 0 1 1 1 0 ImcF-related N-terminal domain Dicty_REP PF05086.12 EFA86408.1 - 0.39 8.6 16.1 0.36 8.7 2.5 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein p450 PF00067.22 EFA86409.1 - 3.2e-51 174.5 0.3 5e-51 173.9 0.3 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF4419 PF14388.6 EFA86410.1 - 2.7e-21 76.3 0.5 4.3e-21 75.6 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) DUF4419 PF14388.6 EFA86411.1 - 2.1e-46 158.7 7.4 1.7e-33 116.4 0.5 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4419) Prefoldin_2 PF01920.20 EFA86412.1 - 1.1e-22 80.0 4.5 2e-22 79.1 4.5 1.4 1 0 0 1 1 1 1 Prefoldin subunit CASP_C PF08172.12 EFA86412.1 - 0.012 15.0 2.8 0.024 14.0 2.8 1.4 1 0 0 1 1 1 0 CASP C terminal OmpH PF03938.14 EFA86412.1 - 0.052 13.9 6.7 0.17 12.2 0.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1664 PF07889.12 EFA86412.1 - 1.1 9.3 4.7 5.1 7.2 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Helicase_C PF00271.31 EFA86413.1 - 6.3e-14 52.3 0.1 3e-13 50.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3073 PF11273.8 EFA86414.1 - 0.93 10.3 3.9 2.5 8.9 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) CC190 PF15768.5 EFA86414.1 - 2.3 8.2 5.3 4.8 7.2 5.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 UCH PF00443.29 EFA86415.1 - 7.9e-44 150.1 44.7 3e-23 82.6 6.8 2.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFA86415.1 - 8.4e-14 51.9 49.2 2.1e-11 44.0 49.2 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Androgen_recep PF02166.16 EFA86415.1 - 0.36 9.6 3.0 0.56 9.0 3.0 1.3 1 0 0 1 1 1 0 Androgen receptor Utp14 PF04615.13 EFA86415.1 - 6.1 5.3 23.1 8.3 4.9 23.1 1.1 1 0 0 1 1 1 0 Utp14 protein PNISR PF15996.5 EFA86415.1 - 6.9 6.9 25.7 86 3.3 25.7 2.1 1 1 0 1 1 1 0 Arginine/serine-rich protein PNISR SAM_PNT PF02198.16 EFA86416.1 - 0.0081 16.1 0.1 0.021 14.8 0.1 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Beta-TrCP_D PF12125.8 EFA86416.1 - 0.0087 15.9 0.2 0.032 14.1 0.2 1.9 1 0 0 1 1 1 1 D domain of beta-TrCP XPG_N PF00752.17 EFA86417.1 - 1e-24 86.9 0.0 1e-24 86.9 0.0 2.7 3 1 0 3 3 3 1 XPG N-terminal domain XPG_I PF00867.18 EFA86417.1 - 3.1e-20 72.3 0.0 3.1e-20 72.3 0.0 6.0 6 2 1 7 7 7 1 XPG I-region UBM PF14377.6 EFA86417.1 - 0.034 13.6 0.2 0.086 12.3 0.2 1.7 1 0 0 1 1 1 0 Ubiquitin binding region Glycos_trans_3N PF02885.17 EFA86419.1 - 0.15 11.9 0.9 0.63 9.9 0.3 2.1 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain DUF4148 PF13663.6 EFA86419.1 - 0.2 11.8 0.6 0.37 11.0 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Methyltr_RsmB-F PF01189.17 EFA86421.1 - 1.5e-37 129.2 0.0 1.7e-36 125.7 0.0 2.4 2 1 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EFA86421.1 - 0.017 15.6 1.4 0.075 13.5 0.0 2.6 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EFA86421.1 - 0.026 14.6 0.0 0.063 13.4 0.0 1.7 1 0 0 1 1 1 0 FtsJ-like methyltransferase FAM60A PF15396.6 EFA86421.1 - 9.2 6.2 8.8 3.5 7.6 2.2 2.6 2 0 0 2 2 2 0 Protein Family FAM60A eIF-5_eIF-2B PF01873.17 EFA86422.1 - 3.4e-37 126.9 0.4 6.4e-37 126.0 0.4 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 EFA86422.1 - 0.013 15.0 0.5 0.027 14.0 0.5 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding DUF5427 PF10310.9 EFA86422.1 - 0.68 8.8 21.7 1.1 8.1 21.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ndc1_Nup PF09531.10 EFA86422.1 - 1.2 7.7 8.6 2 7.0 8.6 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Arc_trans_TRASH PF08394.10 EFA86422.1 - 1.3 9.5 5.7 1 9.8 0.3 2.8 1 1 1 2 2 2 0 Archaeal TRASH domain SRP-alpha_N PF04086.13 EFA86422.1 - 5.8 6.7 28.6 8.8 6.2 28.6 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Pinin_SDK_memA PF04696.13 EFA86423.1 - 3.2e-09 36.9 9.4 3.2e-09 36.9 9.4 5.0 3 2 1 4 4 4 1 pinin/SDK/memA/ protein conserved region GPS2_interact PF15784.5 EFA86423.1 - 0.001 19.4 5.2 0.001 19.4 5.2 4.7 4 2 0 4 4 4 1 G-protein pathway suppressor 2-interacting domain TPR_2 PF07719.17 EFA86424.1 - 3.6e-12 45.4 1.7 0.54 10.5 1.5 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86424.1 - 2.9e-11 43.5 0.3 0.0027 18.0 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86424.1 - 2.1e-07 30.6 6.1 0.31 11.4 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFA86424.1 - 4.4e-07 29.8 5.5 0.037 14.4 0.0 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86424.1 - 5e-07 29.3 2.7 2.6 8.0 1.8 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86424.1 - 4.6e-06 27.0 0.5 0.017 15.6 0.2 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA86424.1 - 4.6e-05 23.2 2.4 8.4 6.7 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86424.1 - 0.00012 22.6 0.1 2.5 9.2 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFA86424.1 - 0.0015 18.2 2.4 3.8 7.3 0.1 4.6 3 1 1 4 4 4 1 TPR repeat SDA1 PF05285.12 EFA86424.1 - 0.0043 16.5 12.1 0.0043 16.5 12.1 2.7 3 0 0 3 3 3 1 SDA1 TPR_9 PF13371.6 EFA86424.1 - 0.18 12.0 1.4 18 5.5 0.0 3.5 3 1 2 5 5 4 0 Tetratricopeptide repeat MIT PF04212.18 EFA86424.1 - 0.31 11.1 6.7 2.5 8.2 0.0 3.5 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EFA86424.1 - 0.9 9.5 5.6 96 3.1 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA86424.1 - 3.5 8.5 5.7 54 4.7 0.0 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat CBM49 PF09478.10 EFA86426.1 - 7.7e-16 58.2 1.3 1.3e-15 57.5 1.3 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 BBS2_Mid PF14783.6 EFA86426.1 - 0.03 14.4 0.1 0.044 13.8 0.1 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region SH3_10 PF17902.1 EFA86426.1 - 0.036 14.1 0.1 0.075 13.1 0.0 1.6 1 1 1 2 2 2 0 SH3 domain DUF1735 PF08522.10 EFA86426.1 - 0.065 13.8 0.0 0.096 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1735) Fic PF02661.18 EFA86428.1 - 2.5e-36 124.5 0.0 1.6e-18 67.3 0.0 3.9 4 0 0 4 4 4 3 Fic/DOC family PilS PF08805.11 EFA86428.1 - 0.009 15.8 0.2 0.47 10.3 0.0 2.4 2 0 0 2 2 2 2 PilS N terminal APG6 PF04111.12 EFA86429.1 - 4.6e-48 163.5 4.1 4e-47 160.5 0.3 3.2 3 0 0 3 3 3 1 Apg6 BARA domain APG6_N PF17675.1 EFA86429.1 - 2.1e-06 28.3 11.1 2.1e-06 28.3 11.1 3.5 2 1 1 3 3 3 1 Apg6 coiled-coil region DUF1192 PF06698.11 EFA86429.1 - 6.6 6.9 8.4 0.25 11.4 0.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Citrate_synt PF00285.21 EFA86430.1 - 5.8e-138 459.9 0.0 7.2e-138 459.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain GDI PF00996.18 EFA86431.1 - 4.5e-213 707.5 0.6 5.3e-213 707.3 0.6 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.24 EFA86431.1 - 0.00039 19.8 0.0 0.00052 19.4 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pkinase_Tyr PF07714.17 EFA86434.1 - 9.3e-49 166.0 0.0 1.2e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFA86434.1 - 9.3e-44 149.8 0.0 1.5e-43 149.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Sod_Cu PF00080.20 EFA86435.1 - 7.4e-48 162.3 6.0 1e-47 161.9 6.0 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF4131 PF13567.6 EFA86435.1 - 0.15 11.7 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) LCM PF04072.14 EFA86437.1 - 2.2e-31 109.3 0.0 3.4e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase HTH_27 PF13463.6 EFA86437.1 - 0.022 15.2 0.0 0.5 10.9 0.0 2.3 2 0 0 2 2 2 0 Winged helix DNA-binding domain ERG2_Sigma1R PF04622.12 EFA86438.1 - 6.3e-59 198.8 0.0 9.7e-59 198.2 0.0 1.2 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein FNIP PF05725.12 EFA86439.1 - 7.3e-52 173.3 32.0 4.8e-15 55.5 1.4 8.7 4 2 2 8 8 8 7 FNIP Repeat DUF1769 PF08588.10 EFA86439.1 - 0.0003 20.9 1.6 0.073 13.3 0.0 4.2 3 1 1 4 4 4 1 Protein of unknown function (DUF1769) Fes1 PF08609.10 EFA86440.1 - 1.9e-06 28.7 3.7 1.9e-06 28.7 3.7 3.5 3 2 0 3 3 3 1 Nucleotide exchange factor Fes1 Arm PF00514.23 EFA86440.1 - 3.1e-06 27.0 0.0 0.0016 18.4 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat DUF3446 PF11928.8 EFA86440.1 - 0.012 16.0 3.9 0.03 14.6 3.9 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain HEAT PF02985.22 EFA86440.1 - 0.023 14.9 0.0 0.098 13.0 0.0 2.1 1 0 0 1 1 1 0 HEAT repeat Nipped-B_C PF12830.7 EFA86440.1 - 0.029 14.3 0.6 0.12 12.3 0.5 2.1 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus HEAT_2 PF13646.6 EFA86440.1 - 0.039 14.4 0.0 0.27 11.7 0.0 2.3 1 1 1 2 2 2 0 HEAT repeats PhnA_Zn_Ribbon PF08274.12 EFA86441.1 - 0.047 13.6 0.9 0.047 13.6 0.9 2.0 2 1 0 2 2 2 0 PhnA Zinc-Ribbon Lar_restr_allev PF14354.6 EFA86441.1 - 0.051 13.9 0.1 0.098 13.1 0.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-RRN7 PF11781.8 EFA86441.1 - 0.077 12.7 1.1 5.9 6.7 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cys_rich_KTR PF14205.6 EFA86441.1 - 0.095 12.5 0.3 0.19 11.6 0.3 1.4 1 0 0 1 1 1 0 Cysteine-rich KTR HNH PF01844.23 EFA86441.1 - 0.12 12.6 2.7 0.27 11.4 1.4 2.1 1 1 1 2 2 2 0 HNH endonuclease TF_Zn_Ribbon PF08271.12 EFA86441.1 - 0.2 11.2 4.4 1.1 8.8 4.4 2.0 1 1 1 2 2 2 0 TFIIB zinc-binding HSP70 PF00012.20 EFA86442.1 - 2.1e-135 452.3 3.1 2.1e-135 452.3 3.1 1.9 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EFA86442.1 - 3.1e-12 46.0 0.0 6e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein APCDDC PF14921.6 EFA86444.1 - 0.071 12.5 0.0 0.071 12.5 0.0 1.1 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 RecA PF00154.21 EFA86446.1 - 5.4e-41 140.8 0.0 8.1e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.11 EFA86446.1 - 2.6e-15 56.4 0.2 1.3e-14 54.1 0.2 1.9 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 EFA86446.1 - 7.2e-08 32.1 0.2 2.2e-06 27.2 0.2 2.4 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EFA86446.1 - 7.5e-06 25.7 0.0 2.5e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain CobU PF02283.16 EFA86446.1 - 8.7e-05 22.2 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_22 PF13401.6 EFA86446.1 - 8.9e-05 22.8 0.0 0.0002 21.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFA86446.1 - 0.00022 21.0 0.0 0.00051 19.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EFA86446.1 - 0.00044 19.7 1.0 0.22 10.9 0.0 2.2 1 1 1 2 2 2 2 DnaB-like helicase C terminal domain AAA_33 PF13671.6 EFA86446.1 - 0.0067 16.6 0.0 0.015 15.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFA86446.1 - 0.074 13.4 0.2 0.76 10.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Zip PF02535.22 EFA86446.1 - 0.14 11.3 2.0 6.7 5.8 0.4 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Corazonin PF17308.2 EFA86446.1 - 0.3 11.4 10.4 0.053 13.9 3.5 2.4 2 0 0 2 2 2 0 Pro-corazonin DUF3682 PF12446.8 EFA86446.1 - 1.5 9.3 10.4 0.43 11.1 7.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) FAM176 PF14851.6 EFA86446.1 - 3 7.5 10.4 0.58 9.8 4.0 2.1 2 0 0 2 2 2 0 FAM176 family HA2 PF04408.23 EFA86447.1 - 3e-23 82.1 0.0 3e-23 82.1 0.0 3.1 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFA86447.1 - 2.6e-19 69.4 0.0 7e-19 68.0 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFA86447.1 - 3.5e-18 66.0 0.3 2.4e-17 63.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFA86447.1 - 3.7e-06 26.8 1.5 6.2e-06 26.1 0.1 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFA86447.1 - 4e-06 27.1 0.0 9.3e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFA86447.1 - 0.00096 19.5 0.1 0.002 18.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFA86447.1 - 0.0032 17.2 0.0 0.0075 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EFA86447.1 - 0.019 15.0 0.2 0.036 14.0 0.2 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EFA86447.1 - 0.35 10.7 0.0 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 Helicase SprA-related PF12118.8 EFA86447.1 - 0.54 9.3 9.5 0.87 8.7 9.5 1.2 1 0 0 1 1 1 0 SprA-related family ResIII PF04851.15 EFA86447.1 - 9.1 6.2 13.8 5 7.1 0.0 3.3 2 1 1 3 3 2 0 Type III restriction enzyme, res subunit 14-3-3 PF00244.20 EFA86448.1 - 2e-105 351.2 4.0 2.3e-105 351.0 4.0 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF4710 PF15828.5 EFA86448.1 - 3.2 7.9 5.1 1.4 9.1 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4710) AAA_17 PF13207.6 EFA86449.1 - 0.0028 18.1 0.0 0.018 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 EFA86450.1 - 4.5e-05 23.7 0.3 4.5e-05 23.7 0.3 3.0 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFA86450.1 - 0.0065 16.1 0.1 0.025 14.2 0.1 1.9 1 0 0 1 1 1 1 Ras family DUF4140 PF13600.6 EFA86450.1 - 0.031 14.7 20.6 0.32 11.5 3.7 3.4 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) OmpH PF03938.14 EFA86450.1 - 2.7 8.3 41.9 1.2 9.4 10.3 3.4 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) PEX11 PF05648.14 EFA86450.1 - 4.6 6.6 7.0 0.72 9.3 0.3 2.4 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Macoilin PF09726.9 EFA86451.1 - 2.3 6.7 13.5 2.7 6.5 13.5 1.1 1 0 0 1 1 1 0 Macoilin family RNase_P_p30 PF01876.16 EFA86452.1 - 1e-48 165.7 0.1 1e-48 165.7 0.1 1.9 3 0 0 3 3 3 1 RNase P subunit p30 Macoilin PF09726.9 EFA86452.1 - 0.079 11.5 5.1 0.1 11.1 5.1 1.1 1 0 0 1 1 1 0 Macoilin family XRCC4 PF06632.12 EFA86452.1 - 0.92 8.3 4.3 1.4 7.7 4.3 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Metallophos PF00149.28 EFA86453.1 - 1.2e-11 45.5 0.9 6.2e-11 43.2 0.9 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA86453.1 - 0.0001 22.5 0.0 0.81 9.9 0.6 2.3 1 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFA86454.1 - 8.9e-13 49.2 2.9 1.4e-12 48.5 2.9 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFA86454.1 - 0.0005 20.3 0.0 0.96 9.6 0.1 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain CARMIL_C PF16000.5 EFA86455.1 - 0.00038 20.2 2.0 0.00038 20.2 2.0 2.0 2 0 0 2 2 2 1 CARMIL C-terminus SPARC_Ca_bdg PF10591.9 EFA86455.1 - 9.3 6.6 9.5 2 8.8 1.8 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region ASH PF15780.5 EFA86456.1 - 0.0052 17.0 0.2 0.006 16.8 0.2 1.0 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin LIM PF00412.22 EFA86457.1 - 2.3e-21 75.8 19.1 1.7e-13 50.5 3.9 2.8 3 0 0 3 3 3 2 LIM domain PH PF00169.29 EFA86457.1 - 1.7e-07 31.7 1.3 7.5e-07 29.6 0.0 2.7 2 0 0 2 2 2 1 PH domain Ras PF00071.22 EFA86458.1 - 0.021 14.4 0.0 0.033 13.8 0.0 1.4 1 1 0 1 1 1 0 Ras family Peptidase_S28 PF05577.12 EFA86462.1 - 1.3e-98 330.6 4.1 1.6e-98 330.4 4.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.7 EFA86462.1 - 0.0052 17.4 0.7 0.017 15.7 0.2 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFA86462.1 - 0.028 14.1 0.2 0.05 13.2 0.2 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFA86462.1 - 0.041 13.1 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DASH_Duo1 PF08651.10 EFA86462.1 - 0.13 12.0 0.1 0.45 10.3 0.1 1.9 1 0 0 1 1 1 0 DASH complex subunit Duo1 LIM PF00412.22 EFA86463.1 - 2.3e-24 85.4 32.1 3.4e-08 33.6 6.5 3.3 3 0 0 3 3 3 3 LIM domain C1_1 PF00130.22 EFA86463.1 - 0.04 13.8 21.7 1.4 8.9 2.1 3.6 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) XAF1_C PF18608.1 EFA86463.1 - 0.067 12.8 7.8 1.5 8.5 1.1 3.8 3 0 0 3 3 3 0 XIAP-associated factor 1 C-terminal domain MTHFR_C PF12225.8 EFA86463.1 - 2.6 7.7 20.8 2.8 7.7 0.7 4.3 4 2 1 5 5 5 0 Methylene-tetrahydrofolate reductase C terminal DUF3716 PF12511.8 EFA86463.1 - 4 7.6 17.8 0.85 9.7 1.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3716) CDC45 PF02724.14 EFA86463.1 - 4.7 5.4 11.7 6.6 4.9 11.7 1.2 1 0 0 1 1 1 0 CDC45-like protein zinc_ribbon_12 PF11331.8 EFA86463.1 - 8.1 6.3 25.5 7.9 6.4 2.5 3.9 3 0 0 3 3 3 0 Probable zinc-ribbon domain Erg28 PF03694.13 EFA86465.1 - 1.5e-26 93.0 5.7 3e-26 92.0 5.7 1.5 1 0 0 1 1 1 1 Erg28 like protein adh_short PF00106.25 EFA86465.1 - 2.6e-23 82.5 0.3 4.6e-23 81.7 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86465.1 - 1.4e-06 28.0 0.0 2.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CBF_beta PF02312.17 EFA86465.1 - 0.00041 20.0 0.0 0.00078 19.1 0.0 1.4 1 0 0 1 1 1 1 Core binding factor beta subunit KR PF08659.10 EFA86465.1 - 0.00051 20.0 0.0 0.00099 19.1 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EFA86466.1 - 3e-23 82.3 0.0 6.1e-23 81.3 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86466.1 - 4.3e-07 29.7 0.0 6.7e-06 25.8 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA86466.1 - 0.00054 19.9 0.0 0.00094 19.1 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFA86466.1 - 0.11 11.6 0.1 0.24 10.5 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein ubiquitin PF00240.23 EFA86467.1 - 4.4e-49 164.1 2.3 1.4e-27 95.2 0.2 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFA86467.1 - 6e-22 77.3 0.7 1.3e-12 47.3 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA86467.1 - 2.8e-09 37.3 0.7 0.0025 18.2 0.0 3.4 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA86467.1 - 3.5e-08 33.3 0.0 0.008 16.1 0.0 2.1 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFA86467.1 - 0.01 16.4 0.0 0.088 13.4 0.0 2.1 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA86467.1 - 0.013 15.5 0.1 0.07 13.2 0.0 2.2 2 2 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFA86467.1 - 0.02 14.9 0.2 8.8 6.5 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA86467.1 - 0.031 14.6 0.2 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain Sec63 PF02889.16 EFA86469.1 - 1.6e-140 466.6 7.6 8e-79 264.4 0.9 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFA86469.1 - 6.3e-54 182.4 3.8 2.7e-28 98.9 1.1 3.7 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 EFA86469.1 - 7.1e-26 91.2 13.4 2e-14 54.0 0.8 4.3 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFA86469.1 - 9.9e-19 67.7 0.1 7.8e-08 32.6 0.0 3.8 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFA86469.1 - 2.4e-06 27.9 2.1 0.019 15.3 0.2 4.2 3 1 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EFA86469.1 - 3.3e-05 24.3 2.1 0.029 14.7 0.6 3.8 4 0 0 4 4 4 1 AAA domain PhoH PF02562.16 EFA86469.1 - 4e-05 23.2 0.1 0.34 10.3 0.0 2.8 2 0 0 2 2 2 2 PhoH-like protein T2SSE PF00437.20 EFA86469.1 - 6.8e-05 22.1 0.0 0.37 9.8 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA PF00004.29 EFA86469.1 - 7.2e-05 23.2 3.1 0.043 14.2 0.0 4.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Helicase_PWI PF18149.1 EFA86469.1 - 0.0019 18.3 0.0 0.0069 16.6 0.0 1.9 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_25 PF13481.6 EFA86469.1 - 0.0022 17.6 0.0 0.29 10.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFA86469.1 - 0.0048 16.6 0.5 1.3 8.7 0.0 3.7 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_7 PF12775.7 EFA86469.1 - 0.0074 15.8 3.9 2.2 7.7 0.0 3.6 4 0 0 4 4 4 2 P-loop containing dynein motor region TniB PF05621.11 EFA86469.1 - 0.3 10.5 7.2 9.1 5.6 0.1 4.2 3 1 0 4 4 4 0 Bacterial TniB protein OAD_gamma PF04277.13 EFA86470.1 - 0.18 12.4 1.2 0.28 11.8 1.2 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PGM_PMM_I PF02878.16 EFA86471.1 - 1.5e-32 112.2 0.0 3.7e-32 110.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EFA86471.1 - 9.7e-21 74.3 0.0 1.9e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFA86471.1 - 3.6e-18 65.8 0.0 6.4e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EFA86471.1 - 2.8e-06 27.4 0.0 7.8e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain zinc_ribbon_5 PF13719.6 EFA86471.1 - 0.036 13.8 0.1 0.2 11.4 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF1682 PF07946.14 EFA86472.1 - 3e-83 279.7 6.8 3.6e-83 279.4 6.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) GRP PF07172.11 EFA86472.1 - 0.048 14.4 0.3 0.048 14.4 0.3 2.4 2 2 0 2 2 2 0 Glycine rich protein family YjbH PF06082.11 EFA86472.1 - 0.53 9.0 4.5 0.82 8.4 4.5 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH CLN3 PF02487.17 EFA86472.1 - 0.53 9.3 6.1 5.5 5.9 0.0 2.2 2 0 0 2 2 2 0 CLN3 protein E1-E2_ATPase PF00122.20 EFA86472.1 - 0.68 9.4 2.5 0.83 9.2 0.0 2.3 4 0 0 4 4 4 0 E1-E2 ATPase SieB PF14163.6 EFA86472.1 - 0.7 9.4 0.0 0.7 9.4 0.0 2.8 3 0 0 3 3 3 0 Super-infection exclusion protein B TRAP-gamma PF07074.12 EFA86472.1 - 3.2 7.3 6.4 21 4.6 0.1 2.4 2 0 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Kei1 PF08552.11 EFA86472.1 - 4.9 7.0 6.2 73 3.2 0.0 2.7 2 1 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 RNA_pol_Rpc4 PF05132.14 EFA86472.1 - 5.9 7.3 9.7 5.8 7.3 3.7 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 C2 PF00168.30 EFA86473.1 - 1.7e-16 60.4 0.2 3.3e-16 59.5 0.2 1.5 1 0 0 1 1 1 1 C2 domain IBR PF01485.21 EFA86473.1 - 1.3e-06 28.5 8.9 1.3e-06 28.5 8.9 6.0 3 2 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 EFA86473.1 - 0.00074 19.5 1.6 0.00074 19.5 1.6 5.5 5 1 1 6 6 6 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFA86473.1 - 0.005 16.8 3.5 0.005 16.8 3.5 6.6 5 4 1 6 6 6 1 zinc-RING finger domain DED PF01335.21 EFA86473.1 - 0.3 11.4 2.9 9.6 6.6 0.3 2.4 1 1 1 2 2 2 0 Death effector domain Ribosomal_L13e PF01294.18 EFA86474.1 - 2.9e-73 245.6 5.8 4.2e-73 245.0 5.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e DPBB_1 PF03330.18 EFA86475.1 - 2.1e-07 31.1 0.5 4.9e-06 26.7 0.5 2.6 1 1 0 1 1 1 1 Lytic transglycolase Cerato-platanin PF07249.12 EFA86475.1 - 0.00071 19.7 2.5 0.00079 19.5 0.5 2.2 2 1 0 2 2 2 1 Cerato-platanin Barwin PF00967.17 EFA86475.1 - 0.0097 15.8 0.1 0.02 14.7 0.1 1.6 1 0 0 1 1 1 1 Barwin family CCDC53 PF10152.9 EFA86475.1 - 0.09 13.2 0.5 0.11 12.9 0.5 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TFIIA PF03153.13 EFA86475.1 - 0.25 11.3 3.8 0.31 11.0 3.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AMPK1_CBM PF16561.5 EFA86476.1 - 9e-36 122.0 0.1 2.4e-35 120.6 0.1 1.8 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EFA86476.1 - 1.3e-21 76.7 5.8 1.3e-21 76.7 5.8 2.7 2 1 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 EFA86476.1 - 0.0024 18.2 0.1 0.0075 16.6 0.0 1.8 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) UBM PF14377.6 EFA86476.1 - 0.34 10.4 0.1 0.34 10.4 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin binding region POPLD PF08170.12 EFA86476.1 - 0.51 10.7 4.7 23 5.4 5.3 2.4 2 0 0 2 2 2 0 POPLD (NUC188) domain SOBP PF15279.6 EFA86476.1 - 3.4 8.2 31.7 0.24 12.0 26.0 1.8 2 0 0 2 2 2 0 Sine oculis-binding protein Cpn60_TCP1 PF00118.24 EFA86478.1 - 3.4e-94 316.2 9.9 4.3e-85 286.2 4.5 3.3 2 1 0 2 2 2 2 TCP-1/cpn60 chaperonin family Imm40 PF15569.6 EFA86478.1 - 0.2 11.8 3.1 0.22 11.6 1.1 2.2 2 0 0 2 2 2 0 Immunity protein 40 TFIIA PF03153.13 EFA86479.1 - 0.0022 18.1 21.0 0.0025 17.9 21.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 EFA86479.1 - 0.22 8.6 14.6 0.23 8.6 14.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4145 PF13643.6 EFA86479.1 - 0.33 11.1 1.9 1.4 9.1 0.0 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4145) Zip PF02535.22 EFA86479.1 - 0.56 9.4 5.5 0.66 9.1 5.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EFA86479.1 - 0.74 8.5 11.0 0.98 8.1 11.0 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EFA86479.1 - 0.8 8.2 16.4 1 7.8 16.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 EFA86479.1 - 9.2 5.5 9.6 15 4.8 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exo_endo_phos PF03372.23 EFA86480.1 - 0.00023 20.8 0.0 0.00044 19.8 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Oxidored_FMN PF00724.20 EFA86481.1 - 3e-65 220.7 0.0 3.7e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFA86481.1 - 0.025 13.7 0.0 0.19 10.8 0.0 2.0 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) ubiquitin PF00240.23 EFA86483.1 - 2.1e-11 43.4 0.0 5.1e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFA86483.1 - 2.3e-08 33.8 0.1 1.2e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF3990 PF13151.6 EFA86483.1 - 0.00019 21.1 0.1 0.00041 20.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) Ubiquitin_5 PF18037.1 EFA86483.1 - 0.019 15.3 0.0 0.055 13.8 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-like domain ART-PolyVal PF18760.1 EFA86483.1 - 0.054 14.5 0.1 0.12 13.4 0.1 1.6 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins DUF3990 PF13151.6 EFA86484.1 - 0.014 15.1 0.1 0.026 14.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) ART-PolyVal PF18760.1 EFA86484.1 - 0.084 13.9 0.1 0.16 13.0 0.1 1.6 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins PARP PF00644.20 EFA86484.1 - 0.13 11.9 1.2 1.1 8.9 0.0 2.6 2 2 2 4 4 4 0 Poly(ADP-ribose) polymerase catalytic domain Lip_prot_lig_C PF10437.9 EFA86485.1 - 1.1e-20 73.3 0.1 2.4e-20 72.3 0.1 1.6 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus BPL_LplA_LipB PF03099.19 EFA86485.1 - 0.027 14.4 0.0 0.088 12.7 0.0 1.8 1 1 0 1 1 1 0 Biotin/lipoate A/B protein ligase family FAD_binding_3 PF01494.19 EFA86486.1 - 6.6e-19 68.4 0.0 8.8e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EFA86486.1 - 7.6e-11 41.5 0.0 2.9e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase DAO PF01266.24 EFA86486.1 - 1.6e-10 41.1 0.0 3.1e-05 23.7 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFA86486.1 - 1.8e-07 30.7 0.4 4.2e-05 22.9 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFA86486.1 - 4.8e-07 30.2 0.1 1e-05 26.0 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFA86486.1 - 4.4e-06 26.8 0.2 1.5e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFA86486.1 - 7.3e-06 25.4 0.6 2.2e-05 23.8 0.1 2.0 2 1 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EFA86486.1 - 8.9e-05 21.7 0.0 0.26 10.3 0.0 2.9 3 0 0 3 3 3 2 Lycopene cyclase protein HI0933_like PF03486.14 EFA86486.1 - 0.00031 19.6 0.0 0.0005 18.9 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 EFA86486.1 - 0.00057 19.1 0.0 0.0012 18.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.16 EFA86486.1 - 0.0032 17.1 0.0 0.46 10.1 0.0 2.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 EFA86486.1 - 0.019 14.3 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFA86486.1 - 0.022 13.9 0.0 0.043 12.9 0.0 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 EFA86486.1 - 0.13 11.3 0.1 10 5.1 0.0 2.4 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 EFA86486.1 - 0.14 12.0 1.2 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1202 PF06717.11 EFA86488.1 - 0.026 14.0 1.3 0.04 13.3 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) Pentapeptide_3 PF13576.6 EFA86489.1 - 0.1 12.8 0.5 0.32 11.2 0.5 1.8 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Glyco_hydro_16 PF00722.21 EFA86490.1 - 1.9e-29 102.4 0.3 3.7e-29 101.4 0.0 1.5 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 SSP160 PF06933.11 EFA86490.1 - 1.4 7.0 16.6 2 6.5 16.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TMEM154 PF15102.6 EFA86490.1 - 1.8 8.5 12.0 0.11 12.4 6.7 1.7 2 0 0 2 2 2 0 TMEM154 protein family Mucin PF01456.17 EFA86490.1 - 2 8.4 22.0 3.5 7.6 22.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein ubiquitin PF00240.23 EFA86491.1 - 3.2e-129 420.8 47.7 4.9e-32 109.5 0.6 9.2 7 1 1 8 8 8 5 Ubiquitin family Rad60-SLD PF11976.8 EFA86491.1 - 2.1e-55 184.4 32.1 3.5e-14 52.4 0.6 8.2 8 0 0 8 8 8 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFA86491.1 - 8.8e-15 54.9 27.7 0.0035 17.8 0.1 7.9 6 2 2 8 8 7 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EFA86491.1 - 1.5e-09 37.7 20.5 0.31 11.0 0.0 7.2 7 0 0 7 7 7 4 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFA86491.1 - 2e-08 34.3 14.2 0.48 10.6 0.1 6.8 5 1 1 6 6 6 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFA86491.1 - 7.8e-05 23.2 28.5 1.3 9.6 0.0 7.8 4 1 1 7 7 6 4 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFA86491.1 - 0.0007 19.9 35.3 0.23 11.8 0.1 6.7 7 1 1 8 8 6 4 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFA86491.1 - 0.023 14.7 23.0 80 3.4 0.0 9.6 9 0 0 9 9 9 0 Ubiquitin-like domain DUF969 PF06149.12 EFA86491.1 - 0.054 12.9 0.0 1e+02 2.2 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF969) ORF11CD3 PF10549.9 EFA86491.1 - 0.13 12.4 7.4 1.9e+02 2.2 0.7 6.7 6 0 0 6 6 6 0 ORF11CD3 domain YcgR_2 PF12945.7 EFA86491.1 - 0.4 10.8 9.6 50 4.1 0.1 5.2 5 0 0 5 5 5 0 Flagellar protein YcgR UDP-g_GGTase PF06427.11 EFA86491.1 - 0.41 10.8 10.0 37 4.5 0.1 5.1 5 0 0 5 5 5 0 UDP-glucose:Glycoprotein Glucosyltransferase MMS19_N PF14500.6 EFA86492.1 - 0.012 15.2 0.8 0.18 11.4 0.0 2.4 2 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 EFA86492.1 - 0.024 14.9 0.7 0.82 10.1 0.2 2.9 2 0 0 2 2 2 0 HEAT repeat Trp_halogenase PF04820.14 EFA86493.1 - 2e-12 46.8 0.0 6.1e-07 28.6 0.0 2.3 1 1 1 2 2 2 2 Tryptophan halogenase DAO PF01266.24 EFA86493.1 - 2.2e-06 27.5 0.1 4.5e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFA86493.1 - 0.00031 20.1 0.0 0.00079 18.7 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFA86493.1 - 0.00065 19.9 0.0 0.0026 18.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFA86493.1 - 0.0049 16.9 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFA86493.1 - 0.0053 16.1 1.1 0.03 13.6 0.1 2.3 2 1 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 EFA86493.1 - 0.0054 15.9 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFA86493.1 - 0.0065 15.7 0.0 0.018 14.3 0.0 1.7 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 EFA86493.1 - 0.007 15.7 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EFA86493.1 - 0.0077 15.3 0.0 0.03 13.4 0.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EFA86493.1 - 0.052 12.2 0.0 0.096 11.4 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EFA86493.1 - 0.075 13.6 0.6 0.47 11.0 0.0 2.6 3 1 1 4 4 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFA86493.1 - 0.096 12.0 0.1 0.74 9.1 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EFA86493.1 - 0.3 10.1 3.2 0.5 9.4 0.6 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A ketoacyl-synt PF00109.26 EFA86495.1 - 9.1e-75 251.5 0.1 2.9e-74 249.8 0.1 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA86495.1 - 4.3e-57 194.0 0.0 8.6e-57 193.0 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFA86495.1 - 4.8e-40 137.4 0.0 1.2e-39 136.1 0.0 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EFA86495.1 - 3e-37 128.5 0.0 1.5e-36 126.2 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EFA86495.1 - 6.5e-32 110.0 0.2 2.8e-31 108.0 0.1 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Chal_sti_synt_C PF02797.15 EFA86495.1 - 1.5e-25 89.9 0.0 3.6e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EFA86495.1 - 1.8e-18 66.8 0.1 5.4e-18 65.2 0.2 1.8 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain ADH_zinc_N PF00107.26 EFA86495.1 - 1.3e-15 57.5 0.0 7.7e-15 55.0 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase FAE1_CUT1_RppA PF08392.12 EFA86495.1 - 1.6e-12 47.4 0.3 1.6e-12 47.4 0.3 1.6 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein PP-binding PF00550.25 EFA86495.1 - 2.1e-12 47.2 0.2 6.8e-12 45.6 0.2 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.6 EFA86495.1 - 3.1e-11 44.4 0.0 1.9e-10 41.9 0.0 2.4 2 0 0 2 2 1 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EFA86495.1 - 4.1e-10 40.1 0.6 2.3e-09 37.7 0.6 2.3 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension ACP_syn_III_C PF08541.10 EFA86495.1 - 3.2e-08 33.6 0.2 8.3e-06 25.9 0.0 4.2 4 0 0 4 4 4 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Thiolase_N PF00108.23 EFA86495.1 - 6e-08 32.4 1.0 9.3e-06 25.2 0.1 2.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain ADH_N PF08240.12 EFA86495.1 - 1e-07 31.8 0.0 2.8e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EFA86495.1 - 2.3e-06 27.2 0.1 9.9e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase ACP_syn_III PF08545.10 EFA86495.1 - 0.00037 20.3 5.5 0.013 15.4 0.6 3.3 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YjeF_N PF03853.15 EFA86495.1 - 0.073 12.9 0.1 0.48 10.3 0.0 2.2 2 0 0 2 2 2 0 YjeF-related protein N-terminus dCache_2 PF08269.11 EFA86495.1 - 0.1 11.8 0.2 0.2 10.8 0.2 1.4 1 0 0 1 1 1 0 Cache domain Yuri_gagarin PF15934.5 EFA86495.1 - 1.1 9.1 3.2 32 4.2 1.1 2.5 2 0 0 2 2 2 0 Yuri gagarin Polysacc_deac_1 PF01522.21 EFA86496.1 - 3.6e-19 68.9 0.1 1e-17 64.2 0.1 2.4 2 0 0 2 2 2 1 Polysaccharide deacetylase EPL1 PF10513.9 EFA86496.1 - 0.016 15.6 2.2 0.016 15.6 2.2 3.9 3 1 0 3 3 3 0 Enhancer of polycomb-like V_ATPase_I PF01496.19 EFA86496.1 - 1.4 6.7 23.1 0.013 13.5 5.1 2.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Macoilin PF09726.9 EFA86496.1 - 6.6 5.2 37.0 0.0071 15.0 9.4 2.3 2 1 0 2 2 2 0 Macoilin family Alpha_kinase PF02816.18 EFA86497.1 - 2.6e-17 63.5 0.0 6.5e-17 62.3 0.0 1.6 1 1 0 1 1 1 1 Alpha-kinase family WD40 PF00400.32 EFA86497.1 - 2.4e-07 31.3 4.7 0.015 16.1 0.1 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 EFA86497.1 - 0.00085 18.1 2.3 0.0016 17.2 0.4 2.0 2 1 1 3 3 3 1 Nucleoporin Nup120/160 WD40_like PF17005.5 EFA86497.1 - 0.16 11.3 0.2 0.27 10.5 0.2 1.2 1 0 0 1 1 1 0 WD40-like domain TFIIA PF03153.13 EFA86497.1 - 0.96 9.4 35.8 1.5 8.8 35.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MIG-14_Wnt-bd PF06664.12 EFA86498.1 - 7.2e-62 209.2 36.8 7.2e-62 209.2 36.8 1.5 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF1980 PF09323.10 EFA86498.1 - 0.00038 20.4 2.5 0.00038 20.4 2.5 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF1980) Glycophorin_A PF01102.18 EFA86498.1 - 0.22 11.8 1.6 0.59 10.4 1.6 1.7 1 0 0 1 1 1 0 Glycophorin A Mu-conotoxin PF05374.12 EFA86498.1 - 0.49 10.5 1.0 1 9.4 1.0 1.5 1 0 0 1 1 1 0 Mu-Conotoxin WD40 PF00400.32 EFA86499.1 - 1.3e-14 54.3 8.3 4e-05 24.3 0.1 5.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA86499.1 - 0.00018 21.7 0.1 0.56 10.5 0.0 3.3 3 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA86499.1 - 0.0021 16.8 3.2 0.063 11.9 0.0 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 fn3 PF00041.21 EFA86500.1 - 9.6e-41 138.0 53.6 0.00019 21.7 1.1 16.5 16 0 0 16 16 16 12 Fibronectin type III domain Tissue_fac PF01108.17 EFA86500.1 - 2.2e-08 33.9 31.5 0.00054 19.8 1.4 10.0 10 2 1 11 11 11 3 Tissue factor EGF_2 PF07974.13 EFA86500.1 - 5.1e-06 26.8 10.8 1.9e-05 24.9 10.8 2.1 1 0 0 1 1 1 1 EGF-like domain ObR_Ig PF18589.1 EFA86500.1 - 0.00015 22.1 18.3 29 5.1 0.1 10.6 10 2 1 12 12 11 0 Obesity receptor immunoglobulin like domain Pur_ac_phosph_N PF16656.5 EFA86500.1 - 0.00073 20.1 64.5 2.6 8.7 0.1 13.7 11 5 3 14 14 13 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 EFA86500.1 - 0.0013 19.1 42.0 14 6.1 0.0 12.3 13 0 0 13 13 12 0 Uncharacterised conserved protein (DUF2369) EGF PF00008.27 EFA86500.1 - 0.0055 17.0 5.6 0.028 14.7 5.6 2.4 1 0 0 1 1 1 1 EGF-like domain ASH PF15780.5 EFA86500.1 - 0.032 14.4 7.3 5.6 7.2 0.0 5.1 4 0 0 4 4 3 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin MLTD_N PF06474.12 EFA86500.1 - 0.041 14.1 0.6 16 5.8 0.1 2.8 2 0 0 2 2 2 0 MltD lipid attachment motif hEGF PF12661.7 EFA86500.1 - 0.77 10.5 5.0 5.1 7.9 5.0 2.6 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFA86500.1 - 1.6 8.9 6.0 5.1 7.2 6.0 1.9 1 0 0 1 1 1 0 Tenascin EGF domain Cystatin PF00031.21 EFA86500.1 - 2.3 8.6 6.3 5.1 7.4 0.1 4.2 4 0 0 4 4 4 0 Cystatin domain I-EGF_1 PF18372.1 EFA86500.1 - 2.5 8.3 8.7 8.1 6.6 8.7 1.9 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 Mating_C PF12737.7 EFA86500.1 - 6.6 5.8 7.9 7.6 5.7 0.4 3.4 3 0 0 3 3 3 0 C-terminal domain of homeodomain 1 Ribosomal_S5_C PF03719.15 EFA86500.1 - 7.7 6.1 6.6 2.2 7.8 0.1 3.4 3 1 1 4 4 4 0 Ribosomal protein S5, C-terminal domain E1-E2_ATPase PF00122.20 EFA86501.1 - 2.7e-41 141.1 1.1 2.7e-41 141.1 1.1 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFA86501.1 - 3.2e-37 128.0 7.8 3.2e-37 128.0 7.8 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFA86501.1 - 5.9e-24 85.5 0.0 1.9e-11 44.7 0.0 3.4 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFA86501.1 - 8e-18 64.3 0.0 3.3e-17 62.3 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFA86501.1 - 6.8e-08 32.1 0.1 4.7e-07 29.4 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFA86501.1 - 0.00053 19.8 0.1 0.0011 18.8 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFA86501.1 - 0.012 16.0 0.0 1.9 8.9 0.0 3.2 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Ras PF00071.22 EFA86502.1 - 1.3e-49 167.9 0.0 1.5e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86502.1 - 1.4e-22 80.2 0.0 2e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA86502.1 - 4.2e-07 29.6 0.0 6.3e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA86502.1 - 0.038 14.1 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase NCOA_u2 PF16665.5 EFA86502.1 - 0.099 13.0 0.1 0.14 12.4 0.1 1.2 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein WD40 PF00400.32 EFA86503.1 - 0.00012 22.8 4.3 0.0063 17.3 0.1 3.6 4 0 0 4 4 4 2 WD domain, G-beta repeat TFIIB PF00382.19 EFA86504.1 - 8.5e-29 99.4 0.8 2.8e-14 52.9 0.1 2.7 1 1 1 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EFA86504.1 - 3.9e-10 40.0 9.0 3.9e-10 40.0 9.0 3.8 2 1 0 2 2 2 1 Brf1-like TBP-binding domain zf-RRN7 PF11781.8 EFA86504.1 - 8.9e-09 34.9 0.5 1.7e-08 34.0 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 EFA86504.1 - 5e-07 29.1 1.8 5e-07 29.1 1.8 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_N PF00134.23 EFA86504.1 - 0.00014 21.6 3.0 0.21 11.4 0.0 2.8 2 1 1 3 3 3 2 Cyclin, N-terminal domain Auto_anti-p27 PF06677.12 EFA86504.1 - 0.0069 16.5 1.1 0.013 15.6 1.1 1.5 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF2877 PF11392.8 EFA86504.1 - 0.35 11.6 0.0 0.35 11.6 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2877) zf-ribbon_3 PF13248.6 EFA86504.1 - 0.71 9.4 3.1 14 5.2 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Ank_2 PF12796.7 EFA86505.1 - 3.1e-08 34.1 1.8 0.14 12.8 0.1 4.8 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA86505.1 - 9.8e-06 25.6 2.7 16 6.5 0.0 6.8 9 0 0 9 9 9 1 Ankyrin repeat Ank_5 PF13857.6 EFA86505.1 - 2.2e-05 24.7 0.1 2.8 8.4 0.0 5.8 5 1 1 6 6 6 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA86505.1 - 0.00014 22.3 4.0 3.8 8.2 0.0 6.1 4 3 3 7 7 7 2 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFA86505.1 - 0.0025 17.7 27.1 0.66 10.0 0.2 7.1 1 1 5 7 7 7 4 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFA86506.1 - 1.5e-09 38.3 0.3 4e-06 27.3 0.2 3.8 2 1 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86506.1 - 1.7e-09 38.0 0.1 0.0038 17.8 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86506.1 - 4.1e-05 23.6 0.2 5.5 7.9 0.0 5.5 6 0 0 6 6 6 1 Ankyrin repeat zf-CCHC PF00098.23 EFA86506.1 - 0.0041 17.1 1.4 0.0083 16.2 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle Ank_5 PF13857.6 EFA86506.1 - 0.0052 17.1 0.0 2.3 8.6 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeats (many copies) LmjF365940-deam PF14421.6 EFA86507.1 - 0.051 13.2 0.0 0.084 12.5 0.0 1.3 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases TFIIA PF03153.13 EFA86509.1 - 0.0017 18.4 13.7 0.0023 18.0 13.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit fn3_3 PF14686.6 EFA86509.1 - 0.075 12.8 0.4 0.16 11.8 0.4 1.6 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II WBP-1 PF11669.8 EFA86509.1 - 0.13 13.0 0.6 0.61 10.8 0.6 2.2 1 0 0 1 1 1 0 WW domain-binding protein 1 Agenet PF05641.12 EFA86509.1 - 0.21 12.1 1.0 1.2 9.7 0.3 2.3 2 0 0 2 2 2 0 Agenet domain Ndc1_Nup PF09531.10 EFA86509.1 - 0.23 10.1 3.2 0.29 9.8 3.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HLH PF00010.26 EFA86509.1 - 0.33 11.0 4.5 0.13 12.2 0.8 2.3 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Presenilin PF01080.17 EFA86509.1 - 8.5 5.0 10.9 15 4.2 10.9 1.4 1 0 0 1 1 1 0 Presenilin DAP3 PF10236.9 EFA86510.1 - 0.027 13.6 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SAM_PNT PF02198.16 EFA86511.1 - 0.032 14.2 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Ribosomal_L18A PF01775.17 EFA86511.1 - 0.056 13.5 0.0 0.12 12.5 0.0 1.6 1 1 0 1 1 1 0 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A SAM_1 PF00536.30 EFA86511.1 - 0.076 13.5 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) FYVE PF01363.21 EFA86512.1 - 5.9e-17 61.6 9.5 1.1e-16 60.8 9.5 1.4 1 0 0 1 1 1 1 FYVE zinc finger Arrestin_N PF00339.29 EFA86512.1 - 2.9e-08 33.9 0.8 3.9e-05 23.7 0.0 3.2 4 0 0 4 4 4 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFA86512.1 - 0.092 13.2 4.2 0.28 11.6 0.4 3.2 4 0 0 4 4 4 0 Arrestin (or S-antigen), C-terminal domain TMEM151 PF14857.6 EFA86512.1 - 0.13 11.2 2.5 0.22 10.4 2.5 1.3 1 0 0 1 1 1 0 TMEM151 family zf-RING_2 PF13639.6 EFA86512.1 - 3.2 8.2 10.0 8 6.9 10.0 1.7 1 1 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EFA86512.1 - 3.2 7.8 11.5 6 6.9 11.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EFA86512.1 - 4.3 7.3 8.5 9.9 6.1 8.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-AN1 PF01428.16 EFA86512.1 - 6 7.1 9.9 40 4.5 9.9 2.2 1 1 0 1 1 1 0 AN1-like Zinc finger IBR PF01485.21 EFA86512.1 - 6.2 7.1 9.5 37 4.7 9.5 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain CH PF00307.31 EFA86513.1 - 1.1e-20 73.8 0.0 3.2e-20 72.3 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFA86513.1 - 2.3e-09 36.9 0.0 4.9e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.11 EFA86513.1 - 0.00049 20.2 0.0 0.0014 18.7 0.0 1.8 1 0 0 1 1 1 1 CH-like domain in sperm protein Kelch_6 PF13964.6 EFA86514.1 - 2.8e-10 40.1 9.7 3.3e-05 24.0 0.4 5.9 6 0 0 6 6 6 3 Kelch motif zf-B_box PF00643.24 EFA86514.1 - 8.5e-07 29.0 8.6 2e-06 27.8 8.6 1.7 1 0 0 1 1 1 1 B-box zinc finger Kelch_3 PF13415.6 EFA86514.1 - 7e-05 23.0 7.8 0.73 10.2 0.0 6.4 6 1 1 7 7 7 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA86514.1 - 0.0094 15.9 4.4 0.12 12.4 0.2 4.3 4 1 1 5 5 5 1 Kelch motif DUF4637 PF15470.6 EFA86514.1 - 8.7 6.0 6.8 7.7 6.2 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF3223 PF11523.8 EFA86515.1 - 1 10.3 5.3 6 7.8 1.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3223) AF-4 PF05110.13 EFA86515.1 - 1.1 7.3 49.4 0.22 9.6 27.0 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein BSP_II PF05432.11 EFA86515.1 - 4.7 6.8 46.5 0.012 15.3 26.5 2.4 2 1 0 2 2 2 0 Bone sialoprotein II (BSP-II) PQ-loop PF04193.14 EFA86516.1 - 3.6e-40 135.6 17.0 1e-19 70.1 8.8 2.8 2 0 0 2 2 2 2 PQ loop repeat LapA_dom PF06305.11 EFA86516.1 - 7.1 6.5 8.6 6.6 6.6 4.8 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain WD40 PF00400.32 EFA86517.1 - 0.00046 20.9 5.6 0.001 19.8 0.0 4.0 3 1 0 3 3 3 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFA86517.1 - 0.00053 19.2 2.3 0.043 12.9 0.4 2.3 2 0 0 2 2 2 2 Coatomer WD associated region Glyco_hydro_14 PF01373.17 EFA86518.1 - 1.5e-112 376.5 1.9 1.7e-112 376.3 1.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 ChitinaseA_N PF08329.10 EFA86518.1 - 0.16 11.6 1.2 22 4.7 0.0 2.8 2 1 1 3 3 3 0 Chitinase A, N-terminal domain Met_10 PF02475.16 EFA86519.1 - 0.082 12.6 0.7 4.8 6.9 0.1 2.1 1 1 1 2 2 2 0 Met-10+ like-protein FHA PF00498.26 EFA86521.1 - 2.9e-08 33.9 0.0 6.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFA86521.1 - 1.7e-06 28.2 0.4 2.6e-05 24.5 0.0 3.2 4 0 0 4 4 4 1 Inner membrane component of T3SS, cytoplasmic domain DUF963 PF06131.11 EFA86521.1 - 0.0058 16.0 9.7 0.0058 16.0 9.7 7.3 5 1 1 6 6 6 3 Schizosaccharomyces pombe repeat of unknown function (DUF963) Ribo_biogen_C PF04034.13 EFA86522.1 - 1.4e-53 180.0 0.0 2.3e-53 179.3 0.0 1.4 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EFA86522.1 - 1.5e-13 50.3 0.1 3.4e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Nop14 PF04147.12 EFA86522.1 - 0.12 10.6 54.0 0.2 9.9 54.0 1.3 1 0 0 1 1 1 0 Nop14-like family Hid1 PF12722.7 EFA86522.1 - 4.3 5.3 22.8 7.6 4.5 22.8 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCSAP PF15748.5 EFA86522.1 - 4.4 7.4 31.9 0.23 11.6 25.2 1.9 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SDA1 PF05285.12 EFA86522.1 - 5.1 6.4 60.7 0.16 11.3 53.4 2.0 2 0 0 2 2 2 0 SDA1 DUF2201_N PF13203.6 EFA86522.1 - 8.5 5.9 12.9 12 5.3 12.9 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain T6SS_HCP PF05638.12 EFA86523.1 - 3.2e-06 27.6 0.0 6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp Spatacsin_C PF14649.6 EFA86524.1 - 1.1e-100 336.7 5.3 2.5e-100 335.5 5.3 1.7 1 0 0 1 1 1 1 Spatacsin C-terminus Peptidase_M20 PF01546.28 EFA86525.1 - 1.2e-35 123.1 0.0 1.5e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFA86525.1 - 1.8e-16 60.0 0.0 4.1e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFA86525.1 - 8.4e-07 28.9 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Methyltransf_2 PF00891.18 EFA86526.1 - 3.8e-43 147.2 0.0 5.1e-43 146.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 EFA86526.1 - 0.16 12.7 0.5 0.81 10.5 0.1 2.3 2 1 0 2 2 2 0 Methyltransferase domain DENN PF02141.21 EFA86527.1 - 4e-51 173.6 9.8 4e-51 173.6 9.8 3.1 4 0 0 4 4 4 1 DENN (AEX-3) domain WD40 PF00400.32 EFA86527.1 - 5.8e-38 128.2 43.8 5.1e-06 27.1 0.7 9.1 8 0 0 8 8 8 7 WD domain, G-beta repeat uDENN PF03456.18 EFA86527.1 - 5.7e-16 59.0 0.5 1.9e-15 57.3 0.5 2.0 1 0 0 1 1 1 1 uDENN domain C2 PF00168.30 EFA86527.1 - 1.3e-10 41.4 0.5 5.7e-10 39.4 0.1 2.2 2 0 0 2 2 2 1 C2 domain SBF2 PF12335.8 EFA86527.1 - 3.3e-06 26.9 1.9 3.3e-06 26.9 1.9 3.4 3 0 0 3 3 3 1 Myotubularin protein dDENN PF03455.19 EFA86527.1 - 3.7e-06 26.8 0.6 3.7e-06 26.8 0.6 2.1 2 0 0 2 2 2 1 dDENN domain WD40_like PF17005.5 EFA86527.1 - 5.7e-06 25.9 7.5 0.048 13.0 0.2 3.6 1 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 EFA86527.1 - 0.00022 20.0 19.4 0.11 11.1 0.1 5.1 3 2 3 6 6 6 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFA86527.1 - 0.0025 18.1 5.0 1 9.7 0.6 4.9 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain KH_1 PF00013.29 EFA86527.1 - 0.11 12.3 1.1 0.34 10.7 1.1 1.8 1 0 0 1 1 1 0 KH domain Mito_carr PF00153.27 EFA86528.1 - 4.8e-69 228.4 1.2 1.5e-26 92.1 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Metallophos PF00149.28 EFA86528.1 - 2e-09 38.3 0.1 1e-07 32.7 0.0 2.6 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase SnoaL_2 PF12680.7 EFA86529.1 - 0.0043 17.7 0.0 0.23 12.1 0.0 2.3 2 0 0 2 2 2 2 SnoaL-like domain Ank_4 PF13637.6 EFA86530.1 - 5.9e-23 80.9 7.8 5.7e-06 26.8 0.1 6.3 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA86530.1 - 6.1e-20 71.0 6.0 6.1e-06 26.4 0.1 5.1 4 1 0 4 4 4 3 Ankyrin repeats (many copies) RGS PF00615.19 EFA86530.1 - 2.7e-19 69.6 3.0 1.5e-14 54.2 0.2 3.1 3 0 0 3 3 3 2 Regulator of G protein signaling domain Ank_2 PF12796.7 EFA86530.1 - 1.1e-17 64.4 7.8 1e-06 29.2 0.3 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFA86530.1 - 2.8e-13 48.8 4.1 0.017 15.6 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFA86530.1 - 6.6e-11 42.2 1.8 0.073 13.5 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat SOG2 PF10428.9 EFA86530.1 - 0.0014 18.0 27.8 0.0021 17.4 27.8 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein Hamartin PF04388.12 EFA86530.1 - 1 7.9 21.2 1.8 7.2 21.2 1.3 1 0 0 1 1 1 0 Hamartin protein SPX PF03105.19 EFA86530.1 - 1.3 8.8 18.6 2.5 7.9 18.6 1.4 1 0 0 1 1 1 0 SPX domain GCOM2 PF15328.6 EFA86530.1 - 3.5 7.9 10.9 10 6.4 10.9 1.8 1 1 0 1 1 1 0 Putative GRINL1B complex locus protein 2 ORC6 PF05460.13 EFA86530.1 - 6.5 5.9 24.3 11 5.2 24.3 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2153 PF09921.9 EFA86531.1 - 0.013 15.3 0.1 1.1 9.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) DUF2121 PF09894.9 EFA86531.1 - 0.1 12.1 0.1 0.21 11.1 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) DUF1494 PF07379.11 EFA86531.1 - 0.51 10.2 3.7 19 5.1 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1494) Peptidase_S80 PF07230.11 EFA86532.1 - 0.16 10.3 0.0 0.26 9.5 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage T4-like capsid assembly protein (Gp20) Sec10 PF07393.11 EFA86534.1 - 3.8e-06 25.7 1.4 5e-06 25.2 1.4 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 RINT1_TIP1 PF04437.13 EFA86534.1 - 0.0007 18.6 4.3 0.00097 18.1 4.3 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family COG4 PF08318.12 EFA86535.1 - 6.1e-13 48.6 0.7 6.1e-13 48.6 0.7 4.0 3 1 1 4 4 4 2 COG4 transport protein Guanylin PF02058.15 EFA86535.1 - 9.8 6.7 7.1 19 5.8 0.7 3.1 2 1 1 3 3 3 0 Guanylin precursor DUF4834 PF16118.5 EFA86535.1 - 9.9 7.2 11.7 25 5.9 3.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 EFA86536.1 - 2.5e-22 79.2 2.0 0.00014 22.4 0.0 5.6 3 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86536.1 - 1.3e-18 67.1 9.5 0.00036 21.1 0.0 8.8 6 3 2 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFA86536.1 - 4.2e-15 55.6 7.7 0.0028 17.9 0.0 8.8 6 4 6 12 12 12 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86536.1 - 1.2e-07 31.4 7.2 18 6.3 0.0 10.2 11 0 0 11 11 11 1 Ankyrin repeat PALP PF00291.25 EFA86537.1 - 6.9e-53 180.0 0.4 1.1e-52 179.3 0.4 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DPBB_1 PF03330.18 EFA86537.1 - 0.066 13.5 2.1 1.1 9.5 2.1 2.4 1 1 0 1 1 1 0 Lytic transglycolase Pollen_allerg_1 PF01357.21 EFA86538.1 - 0.025 14.6 0.1 0.07 13.2 0.1 1.8 1 0 0 1 1 1 0 Pollen allergen SET PF00856.28 EFA86539.1 - 4.5e-14 53.2 4.5 3.8e-13 50.2 4.5 2.1 1 1 0 1 1 1 1 SET domain Nop14 PF04147.12 EFA86539.1 - 0.059 11.6 5.0 0.073 11.3 5.0 1.2 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 EFA86539.1 - 0.82 9.2 9.8 1.3 8.5 9.8 1.3 1 0 0 1 1 1 0 PPP4R2 Zip PF02535.22 EFA86539.1 - 1.4 8.1 3.7 2.1 7.5 3.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RRN3 PF05327.11 EFA86539.1 - 2.1 6.8 12.6 0.97 7.9 8.7 1.9 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Ras PF00071.22 EFA86540.1 - 4.8e-61 205.1 0.1 5.7e-61 204.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86540.1 - 2.5e-20 72.9 0.0 4.5e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA86540.1 - 3.8e-09 36.2 0.0 4.6e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFA86540.1 - 6.3e-06 25.9 0.1 2.9e-05 23.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFA86540.1 - 0.00038 20.4 0.6 0.3 11.0 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFA86540.1 - 0.00056 20.0 0.0 0.00091 19.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFA86540.1 - 0.0095 15.7 1.4 0.052 13.3 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 EFA86540.1 - 0.031 13.6 0.1 0.068 12.4 0.0 1.6 2 0 0 2 2 2 0 Septin FeoB_N PF02421.18 EFA86540.1 - 0.097 12.2 0.1 0.4 10.2 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B HTH_Tnp_Tc5 PF03221.16 EFA86541.1 - 1.4e-09 37.8 0.2 2.6e-09 37.0 0.2 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF4065 PF13274.6 EFA86541.1 - 3.4 8.6 7.5 1 10.2 2.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4065) DUF962 PF06127.11 EFA86543.1 - 0.0056 16.7 2.9 0.013 15.5 2.8 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Sec5 PF15469.6 EFA86544.1 - 9.8e-43 146.2 0.7 9.8e-43 146.2 0.7 2.6 3 0 0 3 3 3 1 Exocyst complex component Sec5 Vps51 PF08700.11 EFA86544.1 - 5.6e-06 26.3 0.8 4e-05 23.6 0.5 2.7 2 0 0 2 2 2 1 Vps51/Vps67 VIT1 PF01988.19 EFA86545.1 - 2.5e-55 187.7 1.8 4.4e-55 186.9 1.8 1.4 1 0 0 1 1 1 1 VIT family DUF4229 PF14012.6 EFA86545.1 - 0.039 14.0 0.3 0.039 14.0 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) TRAM_LAG1_CLN8 PF03798.16 EFA86545.1 - 0.05 13.3 0.2 0.081 12.7 0.2 1.3 1 0 0 1 1 1 0 TLC domain Phage_holin_3_6 PF07332.11 EFA86545.1 - 2.1 8.4 6.4 2.6 8.1 0.4 2.5 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Mucin PF01456.17 EFA86546.1 - 4.2 7.4 7.1 2 8.4 3.2 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Carboxyl_trans PF01039.22 EFA86547.1 - 2.4e-154 514.7 0.1 2.8e-154 514.4 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain ACCA PF03255.14 EFA86547.1 - 0.0047 16.8 0.0 0.33 10.8 0.0 2.6 2 0 0 2 2 2 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MdcE PF06833.11 EFA86547.1 - 0.032 13.7 0.1 0.49 9.8 0.1 2.2 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) DASH_Dad4 PF08650.10 EFA86547.1 - 1.1 9.3 4.1 0.87 9.6 0.6 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad4 ABC_membrane PF00664.23 EFA86548.1 - 1.6e-59 201.9 22.2 1.6e-59 201.9 22.2 2.6 3 0 0 3 3 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFA86548.1 - 1.1e-33 116.6 0.0 2.5e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFA86548.1 - 3.4e-07 29.9 0.1 0.00012 21.6 0.0 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFA86548.1 - 0.0055 16.5 0.1 0.08 12.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFA86548.1 - 0.0066 16.2 0.1 0.018 14.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFA86548.1 - 0.016 14.5 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 EFA86548.1 - 0.029 14.3 0.0 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase DUF2294 PF10057.9 EFA86548.1 - 0.038 14.1 0.1 0.13 12.4 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) AAA_22 PF13401.6 EFA86548.1 - 0.052 13.8 0.4 0.45 10.8 0.4 2.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFA86548.1 - 0.079 13.3 0.3 0.22 11.9 0.1 1.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 EFA86548.1 - 0.079 12.7 1.1 0.08 12.6 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain DUF2474 PF10617.9 EFA86548.1 - 0.11 12.4 2.0 0.33 10.9 2.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) ABC_ATPase PF09818.9 EFA86548.1 - 0.17 10.7 0.9 2.2 7.0 0.1 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DUF5385 PF17359.2 EFA86548.1 - 0.76 9.3 3.6 0.28 10.7 0.4 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5385) TM_helix PF05552.12 EFA86548.1 - 2.3 8.3 8.2 7.5 6.6 3.4 3.5 2 0 0 2 2 2 0 Conserved TM helix AAA_23 PF13476.6 EFA86548.1 - 4.2 7.8 4.8 0.7 10.4 0.4 1.8 2 0 0 2 2 2 0 AAA domain EMP70 PF02990.16 EFA86549.1 - 2.9e-36 125.2 28.6 4.3e-36 124.7 28.6 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 EMP70 PF02990.16 EFA86550.1 - 4.2e-32 111.5 5.5 5.8e-32 111.0 5.5 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 p450 PF00067.22 EFA86551.1 - 7.1e-24 84.4 0.1 8.1e-24 84.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.32 EFA86552.1 - 5.3e-32 109.4 21.1 1.9e-07 31.7 0.0 7.2 8 0 0 8 8 8 6 WD domain, G-beta repeat NLE PF08154.12 EFA86552.1 - 2e-19 69.8 0.1 3.7e-19 69.0 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 EFA86552.1 - 8.4e-07 29.2 3.2 0.029 14.7 0.3 4.8 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFA86552.1 - 0.013 14.1 5.7 0.32 9.6 0.1 3.8 4 1 1 5 5 5 0 Nucleoporin Nup120/160 Cob_adeno_trans PF01923.18 EFA86553.1 - 1.8e-56 190.8 0.0 2.8e-56 190.2 0.0 1.3 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Actin PF00022.19 EFA86555.1 - 4.7e-129 430.6 0.0 4.7e-129 430.6 0.0 3.0 3 1 0 3 3 3 1 Actin SAP PF02037.27 EFA86555.1 - 7.6e-07 28.7 0.2 2e-06 27.4 0.2 1.7 1 0 0 1 1 1 1 SAP domain DUF608 PF04685.13 EFA86556.1 - 9.8e-151 502.0 2.1 1.6e-150 501.3 2.1 1.3 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 EFA86556.1 - 6.1e-101 338.0 2.2 6.1e-101 338.0 2.2 1.6 2 0 0 2 2 2 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Rad9_Rad53_bind PF08605.10 EFA86556.1 - 0.00032 20.9 0.4 18 5.5 0.0 3.6 3 0 0 3 3 3 3 Fungal Rad9-like Rad53-binding DUF2950 PF11453.8 EFA86556.1 - 0.0045 16.2 0.1 21 4.2 0.0 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2950) Chlam_vir PF05475.11 EFA86556.1 - 0.028 14.2 4.3 1.7 8.4 0.1 3.8 3 0 0 3 3 3 0 Pgp3 C-terminal domain DUF1149 PF06619.11 EFA86556.1 - 0.034 14.4 6.7 23 5.3 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1149) MtrF PF09472.10 EFA86556.1 - 0.15 11.5 3.0 3.6 7.1 0.4 2.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) EGF_2 PF07974.13 EFA86556.1 - 1 9.8 59.1 5.1 7.5 14.5 3.6 3 0 0 3 3 3 0 EGF-like domain CRAL_TRIO_2 PF13716.6 EFA86557.1 - 1.3e-17 64.2 0.3 5.8e-17 62.1 0.3 2.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RasGAP PF00616.19 EFA86557.1 - 6.9e-15 55.3 0.3 1.9e-08 34.3 0.0 3.7 2 2 0 3 3 3 2 GTPase-activator protein for Ras-like GTPase RTP1_C1 PF10363.9 EFA86557.1 - 0.005 17.0 0.3 0.1 12.8 0.1 3.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 RICTOR_M PF14666.6 EFA86557.1 - 0.13 12.1 2.2 14 5.5 0.0 4.2 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, middle domain rRNA_processing PF08524.11 EFA86558.1 - 7e-12 45.6 27.9 7e-12 45.6 27.9 3.1 2 1 1 3 3 3 1 rRNA processing LsmAD PF06741.13 EFA86558.1 - 0.019 15.5 6.6 0.019 15.5 6.6 3.7 2 1 1 3 3 3 0 LsmAD domain DUF4111 PF13427.6 EFA86558.1 - 0.033 14.4 0.6 0.033 14.4 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4111) TMEM171 PF15471.6 EFA86558.1 - 0.18 10.8 5.3 0.12 11.3 3.7 1.5 1 1 0 1 1 1 0 Transmembrane protein family 171 KfrA_N PF11740.8 EFA86558.1 - 9.7 6.9 12.0 0.37 11.5 5.8 1.8 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Ras PF00071.22 EFA86559.1 - 1.8e-15 56.9 0.0 5.2e-15 55.4 0.0 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFA86559.1 - 0.0005 20.3 0.3 0.0019 18.4 0.0 2.2 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFA86559.1 - 0.11 12.1 11.4 0.066 12.7 1.3 2.8 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Ndc1_Nup PF09531.10 EFA86559.1 - 1.2 7.7 3.5 1.5 7.4 3.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CRT10 PF08728.10 EFA86559.1 - 1.8 6.7 11.3 2.4 6.2 11.3 1.1 1 0 0 1 1 1 0 CRT10 V_ATPase_I PF01496.19 EFA86559.1 - 2.3 6.0 13.9 3.3 5.5 13.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 EFA86559.1 - 5 7.1 10.0 9.5 6.2 10.0 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NUDIX PF00293.28 EFA86560.1 - 7e-18 64.9 0.0 1.7e-16 60.5 0.0 2.0 2 0 0 2 2 2 2 NUDIX domain adh_short PF00106.25 EFA86561.1 - 1.5e-12 47.4 0.6 1e-11 44.7 0.6 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86561.1 - 1.3e-09 38.0 0.2 5.5e-09 35.9 0.2 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFA86561.1 - 7.5e-07 28.9 0.0 1.1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFA86561.1 - 0.0022 17.1 0.0 0.005 16.0 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EFA86561.1 - 0.0071 15.8 0.0 0.32 10.4 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Eno-Rase_NADH_b PF12242.8 EFA86561.1 - 0.029 14.1 1.4 0.1 12.4 0.1 2.5 2 1 1 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NmrA PF05368.13 EFA86561.1 - 0.084 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family FRD2 PF03197.13 EFA86561.1 - 0.15 12.4 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage FRD2 protein Ribosomal_S17_N PF16205.5 EFA86562.1 - 1.5e-28 98.9 0.5 3.2e-28 97.9 0.5 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EFA86562.1 - 1.4e-24 86.0 0.7 2.3e-24 85.3 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 FGF-BP1 PF06473.12 EFA86564.1 - 0.0056 16.6 4.1 0.0056 16.6 4.1 1.6 2 0 0 2 2 2 1 FGF binding protein 1 (FGF-BP1) FAA_hydro_N_2 PF18288.1 EFA86564.1 - 0.016 15.6 0.1 0.038 14.4 0.1 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 DUF5386 PF17360.2 EFA86564.1 - 0.041 13.8 0.1 0.058 13.3 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5386) DUF4298 PF14131.6 EFA86564.1 - 0.6 10.1 14.9 0.049 13.6 2.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) DUF2347 PF09804.9 EFA86564.1 - 2.4 7.6 9.1 0.78 9.3 2.8 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) ABC2_membrane_3 PF12698.7 EFA86564.1 - 3.3 6.7 7.1 0.74 8.9 3.5 1.6 1 1 1 2 2 2 0 ABC-2 family transporter protein LUD_dom PF02589.15 EFA86565.1 - 3.8e-21 75.7 0.0 4.8e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 LUD domain AbiEi_3 PF11459.8 EFA86565.1 - 0.15 11.8 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system PfkB PF00294.24 EFA86566.1 - 0.074 12.4 0.5 0.095 12.0 0.5 1.1 1 0 0 1 1 1 0 pfkB family carbohydrate kinase LUD_dom PF02589.15 EFA86567.1 - 3.4e-32 111.7 0.0 3.9e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 LUD domain DHquinase_II PF01220.19 EFA86567.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Dehydroquinase class II Rap_GAP PF02145.15 EFA86568.1 - 7.2e-61 205.0 0.0 1e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP ArfGap PF01412.18 EFA86569.1 - 4.1e-35 120.4 0.3 4.1e-35 120.4 0.3 3.9 4 1 1 5 5 5 1 Putative GTPase activating protein for Arf DUF3446 PF11928.8 EFA86569.1 - 0.0033 17.7 7.3 0.0033 17.7 7.3 7.9 5 3 1 6 6 6 1 Early growth response N-terminal domain DUF3915 PF13054.6 EFA86569.1 - 0.013 15.5 0.6 0.013 15.5 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) ROS_MUCR PF05443.11 EFA86569.1 - 0.034 14.2 0.0 0.13 12.4 0.0 2.0 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein adh_short PF00106.25 EFA86570.1 - 3e-37 128.0 0.0 4e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFA86570.1 - 2.4e-21 76.4 0.0 3e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFA86570.1 - 3.8e-11 43.2 0.0 5.7e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFA86570.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family FAD_binding_3 PF01494.19 EFA86571.1 - 1.4e-14 54.1 0.0 2.1e-07 30.5 0.0 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EFA86571.1 - 1.1e-05 25.6 0.0 3e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFA86571.1 - 0.0025 17.5 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EFA86571.1 - 0.0029 17.6 0.0 0.0077 16.3 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EFA86571.1 - 0.0042 16.7 0.1 0.0092 15.6 0.1 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EFA86571.1 - 0.0071 16.9 0.0 0.021 15.3 0.0 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFA86571.1 - 0.0073 15.6 0.0 0.021 14.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA86571.1 - 0.009 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFA86571.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family K_oxygenase PF13434.6 EFA86571.1 - 0.034 13.3 0.0 0.096 11.8 0.0 1.6 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_Gly3P_dh_N PF01210.23 EFA86571.1 - 0.052 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HI0933_like PF03486.14 EFA86571.1 - 0.098 11.3 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Fil_haemagg PF05594.14 EFA86571.1 - 0.12 12.9 0.9 8.5 7.0 0.1 2.7 2 1 0 2 2 2 0 Haemagluttinin repeat NAD_binding_9 PF13454.6 EFA86571.1 - 0.18 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF3671 PF12420.8 EFA86572.1 - 1.8 8.6 13.6 0.42 10.7 6.9 2.7 2 1 1 3 3 3 0 Protein of unknown function FH2 PF02181.23 EFA86573.1 - 7.5e-79 265.5 16.3 1.2e-71 241.8 4.7 3.4 3 0 0 3 3 3 2 Formin Homology 2 Domain Drf_GBD PF06371.13 EFA86573.1 - 2e-39 135.1 0.2 2e-39 135.1 0.2 2.4 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFA86573.1 - 7.8e-06 25.6 0.3 7.8e-06 25.6 0.3 2.4 2 0 0 2 2 2 1 Diaphanous FH3 Domain MMS19_N PF14500.6 EFA86574.1 - 8.7e-84 281.2 9.9 1.3e-83 280.6 0.0 4.1 5 0 0 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 EFA86574.1 - 2.1e-40 139.2 41.7 8.6e-27 94.3 17.3 3.1 2 1 1 3 3 3 2 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 EFA86574.1 - 3.7e-05 24.1 0.5 0.071 13.6 0.0 4.4 4 0 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 EFA86574.1 - 0.0013 19.1 0.0 4.1 7.9 0.0 4.0 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 EFA86574.1 - 0.0082 16.3 3.9 0.43 11.0 0.1 5.0 6 0 0 6 6 6 1 HEAT repeat Cullin_Nedd8 PF10557.9 EFA86574.1 - 0.19 11.8 5.0 46 4.2 0.1 4.4 3 0 0 3 3 3 0 Cullin protein neddylation domain VWA_2 PF13519.6 EFA86575.1 - 0.00056 20.5 0.0 0.00056 20.5 0.0 3.4 4 0 0 4 4 4 1 von Willebrand factor type A domain Mucin PF01456.17 EFA86575.1 - 0.0091 16.0 38.3 0.0091 16.0 38.3 2.1 2 0 0 2 2 2 1 Mucin-like glycoprotein Adeno_PV PF03910.13 EFA86575.1 - 0.37 9.5 5.8 0.56 8.9 5.8 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV CAF1-p150_C2 PF15539.6 EFA86576.1 - 0.24 10.8 2.6 0.54 9.7 2.2 1.8 2 0 0 2 2 2 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term Peptidase_S28 PF05577.12 EFA86577.1 - 8e-73 245.7 0.1 1e-72 245.3 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EFA86577.1 - 5e-05 23.1 0.0 0.0002 21.1 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S37 PF05576.11 EFA86577.1 - 0.0029 16.3 0.0 0.045 12.4 0.0 2.0 2 0 0 2 2 2 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 EFA86577.1 - 0.025 13.9 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 CAP_C PF08603.11 EFA86578.1 - 8.7e-05 22.2 0.8 0.00035 20.2 0.8 1.9 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal SEC-C PF02810.15 EFA86578.1 - 0.077 12.9 2.1 0.15 12.1 2.1 1.5 1 0 0 1 1 1 0 SEC-C motif WD40 PF00400.32 EFA86579.1 - 1.2e-11 44.9 2.7 0.012 16.4 0.4 4.3 5 0 0 5 5 5 3 WD domain, G-beta repeat FNIP PF05725.12 EFA86580.1 - 2.6e-18 65.9 20.6 2.4e-05 24.4 0.7 7.1 8 0 0 8 8 8 4 FNIP Repeat CDC73_C PF05179.14 EFA86581.1 - 9.8e-32 109.8 0.1 2.3e-31 108.6 0.1 1.6 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 EFA86581.1 - 1.5e-23 83.6 1.0 1.6e-18 67.1 0.1 2.1 2 0 0 2 2 2 2 Paf1 complex subunit CDC73 N-terminal ADH_zinc_N PF00107.26 EFA86582.1 - 8.6e-23 80.7 0.0 1.5e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFA86582.1 - 6.1e-10 39.0 0.4 1.5e-09 37.7 0.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFA86582.1 - 3.1e-08 34.7 0.0 5.8e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFA86582.1 - 0.0021 17.4 0.1 0.0031 16.8 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EFA86582.1 - 0.036 14.3 0.1 0.061 13.6 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Nsp1_C PF05064.13 EFA86583.1 - 1.2e-16 60.6 12.3 1.2e-16 60.6 12.3 1.8 1 1 1 2 2 2 1 Nsp1-like C-terminal region DUF3584 PF12128.8 EFA86583.1 - 0.044 11.3 13.6 0.057 10.9 13.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Nup54_C PF18437.1 EFA86583.1 - 0.15 12.0 5.1 0.29 11.1 5.1 1.4 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain DUF2400 PF09674.10 EFA86583.1 - 0.17 11.9 2.3 0.27 11.2 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) DUF5420 PF17457.2 EFA86583.1 - 0.19 11.6 2.3 0.32 10.8 2.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5420) Exonuc_VII_L PF02601.15 EFA86583.1 - 0.2 11.2 6.9 0.31 10.6 6.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AbiGi PF10899.8 EFA86583.1 - 0.21 11.4 1.9 0.34 10.7 1.9 1.3 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin V_ATPase_I PF01496.19 EFA86583.1 - 0.69 7.8 8.9 0.96 7.3 8.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ank_2 PF12796.7 EFA86584.1 - 2.2e-70 233.3 3.5 6.4e-13 49.1 0.1 5.7 1 1 6 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86584.1 - 2.2e-49 165.2 1.6 1.8e-10 41.1 0.0 7.2 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EFA86584.1 - 6.8e-43 143.3 7.9 3.5e-06 27.2 0.1 9.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 EFA86584.1 - 2.2e-40 132.0 1.2 0.00044 20.5 0.0 9.6 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 EFA86584.1 - 4.2e-39 132.1 1.1 1.1e-07 32.0 0.1 7.6 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Homeodomain PF00046.29 EFA86584.1 - 2.6e-18 65.6 1.8 2.6e-18 65.6 1.8 1.9 2 0 0 2 2 2 1 Homeodomain NAD_binding_6 PF08030.12 EFA86585.1 - 1.2e-18 67.7 0.0 1.7e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFA86585.1 - 4.2e-07 30.0 0.0 8.5e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFA86585.1 - 0.056 14.1 0.0 0.1 13.2 0.0 1.5 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain EF-hand_7 PF13499.6 EFA86586.1 - 1.1e-09 38.6 2.4 1.1e-09 38.6 2.4 3.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EFA86586.1 - 7e-09 34.6 5.6 2.7e-06 26.5 1.5 4.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EFA86586.1 - 5.6e-08 32.1 7.3 0.0001 21.9 0.7 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EFA86586.1 - 1.1e-07 31.0 3.6 2.5e-07 29.9 2.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFA86586.1 - 0.01 15.6 2.0 0.046 13.6 1.6 2.4 1 1 1 2 2 2 0 EF-hand domain pair Gelsolin PF00626.22 EFA86587.1 - 5.5e-25 87.1 1.5 3.8e-09 36.3 0.0 6.3 5 0 0 5 5 5 5 Gelsolin repeat CutA1 PF03091.15 EFA86587.1 - 0.34 10.8 12.0 2.8 7.9 0.1 5.0 5 1 0 5 5 5 0 CutA1 divalent ion tolerance protein Complex1_LYR PF05347.15 EFA86588.1 - 7.9e-07 29.0 0.4 2e-06 27.8 0.1 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFA86588.1 - 0.039 14.7 0.1 0.051 14.3 0.1 1.3 1 1 0 1 1 1 0 Complex1_LYR-like SH3_9 PF14604.6 EFA86589.1 - 2.2e-25 88.2 0.9 1.7e-13 50.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EFA86589.1 - 2e-22 78.5 2.6 2.5e-12 46.2 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EFA86589.1 - 3e-21 74.9 0.4 5.3e-10 38.8 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain ABC_tran_CTD PF16326.5 EFA86589.1 - 0.053 13.8 18.1 0.056 13.7 0.4 3.8 2 1 1 3 3 3 0 ABC transporter C-terminal domain LMBR1 PF04791.16 EFA86589.1 - 0.68 8.8 3.7 0.48 9.3 1.7 1.7 2 0 0 2 2 2 0 LMBR1-like membrane protein PilJ PF13675.6 EFA86589.1 - 0.76 9.8 6.1 0.95 9.5 0.1 2.9 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term BLOC1_2 PF10046.9 EFA86589.1 - 1.4 9.3 24.6 3.2 8.1 3.7 4.5 3 1 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CHASE3 PF05227.13 EFA86589.1 - 1.7 8.6 9.8 1.6 8.7 5.1 2.7 2 1 0 2 2 2 0 CHASE3 domain MbeD_MobD PF04899.12 EFA86589.1 - 1.8 8.8 8.6 39 4.5 0.6 3.7 4 0 0 4 4 4 0 MbeD/MobD like V_ATPase_I PF01496.19 EFA86589.1 - 2.3 6.0 16.9 1 7.2 12.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF5446 PF17522.2 EFA86589.1 - 2.3 8.4 8.5 0.24 11.6 0.4 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5446) Spectrin PF00435.21 EFA86589.1 - 4.3 7.9 25.3 2.6 8.6 0.7 4.0 2 1 1 3 3 3 0 Spectrin repeat Fib_alpha PF08702.10 EFA86589.1 - 5.1 7.3 30.0 0.29 11.3 12.3 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 EFA86589.1 - 5.2 6.9 36.8 0.077 12.8 4.2 4.5 2 1 3 5 5 5 0 Septum formation initiator DUF1192 PF06698.11 EFA86589.1 - 6 7.0 7.8 5.2 7.2 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) RRM_1 PF00076.22 EFA86590.1 - 7.7e-08 32.1 0.0 1.8e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFA86590.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFA86590.1 - 0.016 15.1 0.0 0.048 13.5 0.0 1.8 1 0 0 1 1 1 0 Occluded RNA-recognition motif Pkinase PF00069.25 EFA86591.1 - 3e-19 69.4 0.0 4.4e-18 65.6 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86591.1 - 1.3e-12 47.6 0.0 7.6e-06 25.4 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase DUF2967 PF11179.8 EFA86591.1 - 8 4.4 14.4 0.85 7.6 5.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2967) ANAPC_CDC26 PF10471.9 EFA86591.1 - 9.3 7.2 21.0 0.67 10.8 10.9 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 AA_permease_2 PF13520.6 EFA86595.1 - 9.2e-58 196.1 38.3 9.2e-58 196.1 38.3 1.9 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 EFA86595.1 - 3.4e-45 154.6 36.7 5.4e-45 153.9 36.7 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 EFA86595.1 - 1.5e-22 79.4 8.9 1.5e-22 79.4 8.9 3.6 4 0 0 4 4 4 1 C-terminus of AA_permease DUF3493 PF11998.8 EFA86595.1 - 0.088 13.0 1.2 7 6.9 0.8 3.1 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 Chordopox_A13L PF05961.11 EFA86595.1 - 0.22 11.8 1.5 33 4.8 0.0 3.8 3 0 0 3 3 3 0 Chordopoxvirus A13L protein V-SNARE_C PF12352.8 EFA86597.1 - 2.8e-08 33.9 0.3 2.8e-08 33.9 0.3 1.6 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFA86597.1 - 0.007 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Sec20 SpoIIIAH PF12685.7 EFA86597.1 - 0.01 15.7 0.2 0.01 15.7 0.2 1.4 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF4834 PF16118.5 EFA86597.1 - 0.15 13.0 0.1 0.32 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) LAMTOR5 PF16672.5 EFA86598.1 - 2.3e-20 72.3 0.2 2.6e-20 72.1 0.2 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 A_amylase_inhib PF01356.19 EFA86598.1 - 0.07 13.1 0.1 0.15 12.1 0.2 1.5 2 0 0 2 2 2 0 Alpha amylase inhibitor ThiF PF00899.21 EFA86599.1 - 4.9e-64 216.0 0.0 8.9e-64 215.2 0.0 1.4 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EFA86599.1 - 7.3e-22 77.3 0.1 1.2e-21 76.6 0.1 1.4 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.6 EFA86599.1 - 0.0011 19.5 0.1 0.0038 17.8 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Myb_DNA-bind_4 PF13837.6 EFA86599.1 - 0.012 16.0 1.5 0.012 16.0 1.5 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Shikimate_DH PF01488.20 EFA86599.1 - 0.027 14.5 0.1 0.085 12.9 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase UBA_e1_thiolCys PF10585.9 EFA86599.1 - 0.4 10.6 6.9 2.7 7.8 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin-activating enzyme active site eIF3_subunit PF08597.10 EFA86601.1 - 2.1e-48 165.4 24.7 2.3e-48 165.2 24.7 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Glyco_hydro_39 PF01229.17 EFA86601.1 - 0.0071 15.0 0.1 0.01 14.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 CorA PF01544.18 EFA86601.1 - 0.16 11.3 0.6 0.23 10.8 0.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Claudin_3 PF06653.11 EFA86602.1 - 0.92 9.4 10.9 0.04 13.9 4.3 1.9 2 2 0 2 2 2 0 Tight junction protein, Claudin-like Shisa PF13908.6 EFA86604.1 - 0.0033 17.7 0.8 0.0046 17.2 0.8 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF2207 PF09972.9 EFA86604.1 - 0.39 9.4 1.4 0.48 9.1 1.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Myc_target_1 PF15179.6 EFA86604.1 - 0.4 10.6 0.1 0.4 10.6 0.1 1.5 2 0 0 2 2 2 0 Myc target protein 1 Tubulin PF00091.25 EFA86605.1 - 9e-67 225.1 0.0 1.3e-66 224.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFA86605.1 - 2.6e-47 160.1 0.0 4.4e-47 159.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFA86605.1 - 0.00033 20.4 0.1 0.0017 18.1 0.0 2.2 3 0 0 3 3 3 1 Tubulin domain NAD_binding_2 PF03446.15 EFA86605.1 - 0.094 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NinG PF05766.12 EFA86605.1 - 0.15 12.0 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein Pyr_redox_2 PF07992.14 EFA86606.1 - 1.1e-09 37.9 0.1 9.8e-09 34.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFA86606.1 - 0.00015 21.1 1.7 0.12 11.6 0.1 3.4 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFA86606.1 - 0.0012 18.0 0.0 0.0027 16.8 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFA86606.1 - 0.0034 17.6 0.0 0.0087 16.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EFA86606.1 - 0.0055 17.1 0.0 0.74 10.3 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EFA86606.1 - 0.0072 16.3 0.0 0.15 12.1 0.0 3.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.17 EFA86606.1 - 0.012 14.8 0.0 1 8.5 0.0 2.5 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.20 EFA86606.1 - 0.031 14.4 0.2 1.7 8.7 0.0 2.7 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EFA86606.1 - 0.05 14.2 0.2 1.4 9.6 0.1 3.2 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase PTPA PF03095.15 EFA86607.1 - 0.01 15.3 0.2 0.013 15.0 0.2 1.1 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein CENP-F_N PF10481.9 EFA86607.1 - 0.05 13.2 0.1 0.059 13.0 0.1 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain Kelch_6 PF13964.6 EFA86608.1 - 4.3e-14 52.2 3.1 0.00042 20.5 0.2 4.7 3 1 1 4 4 4 4 Kelch motif Kelch_1 PF01344.25 EFA86608.1 - 1.4e-07 31.0 0.4 2.9 7.5 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 EFA86608.1 - 1.5e-06 28.1 1.5 1.6 8.8 0.0 5.2 5 0 0 5 5 5 2 Galactose oxidase, central domain zf-B_box PF00643.24 EFA86608.1 - 7.8e-06 25.9 9.6 7.8e-06 25.9 9.6 2.1 2 0 0 2 2 2 1 B-box zinc finger Kelch_5 PF13854.6 EFA86608.1 - 9.9e-06 25.4 3.1 0.7 9.9 0.1 4.8 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 EFA86608.1 - 0.0051 16.8 2.5 0.31 11.1 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 EFA86609.1 - 0.00035 20.7 5.9 0.088 13.1 0.2 4.1 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFA86609.1 - 0.0026 17.3 4.6 0.0077 15.8 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 EFA86609.1 - 0.025 14.6 5.4 3.8 7.6 0.1 3.4 3 0 0 3 3 3 0 Kelch motif Pepsin-I3 PF06394.13 EFA86609.1 - 0.11 12.7 0.1 0.41 10.9 0.1 2.0 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain Kelch_4 PF13418.6 EFA86609.1 - 0.28 11.2 4.1 7.2 6.7 0.2 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EFA86609.1 - 1.2 9.3 3.5 2.5 8.2 0.7 3.0 2 1 1 3 3 3 0 Kelch motif Big_9 PF17963.1 EFA86610.1 - 0.00063 20.4 51.6 0.075 13.8 0.7 7.5 7 0 0 7 7 7 5 Bacterial Ig domain VWA PF00092.28 EFA86610.1 - 0.0063 16.8 0.1 0.012 15.8 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Laminin_EGF PF00053.24 EFA86610.1 - 3.7 7.8 21.2 32 4.8 12.4 2.5 1 1 1 2 2 2 0 Laminin EGF domain EMP24_GP25L PF01105.24 EFA86611.1 - 2.9e-48 164.2 0.4 3.6e-48 163.9 0.4 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RAMP4 PF06624.12 EFA86611.1 - 0.00036 20.5 0.1 0.00084 19.3 0.0 1.7 2 0 0 2 2 2 1 Ribosome associated membrane protein RAMP4 HAMP PF00672.25 EFA86612.1 - 2e-52 175.3 7.2 4.6e-07 30.1 0.0 8.5 8 0 0 8 8 8 7 HAMP domain Response_reg PF00072.24 EFA86612.1 - 3e-41 140.1 1.0 5.3e-27 94.2 0.5 2.7 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 EFA86612.1 - 4.7e-31 107.6 0.1 1.6e-30 105.9 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFA86612.1 - 2.1e-19 69.3 2.2 7.2e-19 67.6 0.1 3.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GLE1 PF07817.13 EFA86612.1 - 2.5e-11 43.3 1.8 0.65 9.2 0.0 6.4 1 1 5 6 6 6 3 GLE1-like protein SpoIIID PF12116.8 EFA86612.1 - 1.2e-07 31.7 0.3 15 5.8 0.0 6.9 6 0 0 6 6 6 0 Stage III sporulation protein D Laminin_II PF06009.12 EFA86612.1 - 5e-07 29.8 32.0 0.052 13.6 0.1 7.7 7 0 0 7 7 7 4 Laminin Domain II DUF948 PF06103.11 EFA86612.1 - 7e-05 23.0 52.1 2.5 8.4 1.9 12.2 3 2 5 8 8 8 3 Bacterial protein of unknown function (DUF948) WXG100 PF06013.12 EFA86612.1 - 0.00051 20.2 6.7 9.7 6.5 0.1 7.5 7 1 1 8 8 7 1 Proteins of 100 residues with WXG HTH_6 PF01418.17 EFA86612.1 - 0.0049 16.8 1.1 49 4.0 0.0 5.8 6 0 0 6 6 6 0 Helix-turn-helix domain, rpiR family Tup_N PF08581.10 EFA86612.1 - 0.012 15.9 0.1 0.25 11.7 0.0 3.5 2 0 0 2 2 1 0 Tup N-terminal Focal_AT PF03623.13 EFA86612.1 - 0.021 14.8 4.3 19 5.2 0.0 5.8 1 1 2 6 6 6 0 Focal adhesion targeting region Peptidase_M3 PF01432.20 EFA86612.1 - 0.039 13.2 0.4 0.078 12.2 0.4 1.4 1 0 0 1 1 1 0 Peptidase family M3 DUF3829 PF12889.7 EFA86612.1 - 0.11 11.9 17.7 1.1 8.6 0.0 6.6 8 0 0 8 8 8 0 Protein of unknown function (DUF3829) DUF1186 PF06685.11 EFA86612.1 - 0.28 10.5 4.2 6.8 6.0 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1186) LSM PF01423.22 EFA86613.1 - 6.8e-19 67.3 1.5 1e-18 66.7 1.5 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFA86613.1 - 0.05 13.8 0.1 0.05 13.8 0.1 1.5 2 0 0 2 2 2 0 Ataxin 2 SM domain BPL_C PF02237.17 EFA86613.1 - 0.056 13.4 0.2 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain VHP PF02209.19 EFA86614.1 - 7.7e-13 48.3 1.0 1.5e-12 47.4 1.0 1.5 1 0 0 1 1 1 1 Villin headpiece domain Ilar_coat PF01787.16 EFA86614.1 - 1.4 8.7 10.9 0.033 14.0 1.6 2.4 1 1 1 2 2 2 0 Ilarvirus coat protein Ribosomal_L33 PF00471.20 EFA86615.1 - 4.7e-10 39.8 0.1 5.8e-10 39.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L33 COG6 PF06419.11 EFA86617.1 - 4.8e-52 177.1 15.4 8.4e-42 143.2 10.1 3.3 3 0 0 3 3 3 2 Conserved oligomeric complex COG6 ELMO_CED12 PF04727.13 EFA86617.1 - 5e-52 176.6 0.3 5e-52 176.6 0.3 3.2 3 1 0 3 3 3 1 ELMO/CED-12 family DUF3361 PF11841.8 EFA86617.1 - 1.6e-09 37.9 2.1 7e-09 35.8 2.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) PH PF00169.29 EFA86618.1 - 1.1e-18 67.6 0.1 1.1e-18 67.6 0.1 2.7 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFA86618.1 - 2.6e-05 24.4 0.1 8.8e-05 22.7 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EFA86618.1 - 0.0017 18.7 4.0 0.13 12.7 0.1 3.9 4 0 0 4 4 4 2 Pleckstrin homology domain PH_11 PF15413.6 EFA86618.1 - 0.0044 17.4 0.9 0.0044 17.4 0.9 5.7 4 3 2 7 7 7 1 Pleckstrin homology domain DUF1674 PF07896.12 EFA86619.1 - 2.6e-20 72.6 1.2 3.5e-20 72.2 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) BBS2_C PF14782.6 EFA86619.1 - 0.027 13.2 0.6 0.03 13.1 0.6 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal HTH_36 PF13730.6 EFA86619.1 - 0.081 12.9 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_31 PF13614.6 EFA86620.1 - 2.2e-21 76.6 0.0 3.5e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFA86620.1 - 1.8e-16 60.3 0.0 2.5e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EFA86620.1 - 3.1e-16 59.6 0.0 2.6e-15 56.5 0.0 2.2 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 EFA86620.1 - 6e-11 42.1 0.0 9.9e-11 41.4 0.0 1.3 1 1 0 1 1 1 1 ATPase MipZ CBP_BcsQ PF06564.12 EFA86620.1 - 2.3e-07 30.6 0.0 3.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 EFA86620.1 - 1.8e-06 27.4 0.4 6.4e-06 25.6 0.2 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 EFA86620.1 - 5e-06 26.2 0.2 0.073 12.5 0.4 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_24 PF13479.6 EFA86620.1 - 0.00039 20.2 0.2 0.00092 19.0 0.2 1.6 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFA86620.1 - 0.00091 18.9 0.3 0.74 9.4 0.2 2.4 2 1 0 2 2 2 2 SRP54-type protein, GTPase domain ATPase PF06745.13 EFA86620.1 - 0.029 13.7 0.6 0.054 12.8 0.6 1.6 1 1 0 1 1 1 0 KaiC AAA_26 PF13500.6 EFA86620.1 - 0.036 13.9 0.6 1.7 8.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain CLP1_P PF16575.5 EFA86620.1 - 0.064 13.1 0.1 0.2 11.5 0.1 1.9 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_7 PF12775.7 EFA86620.1 - 0.071 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EFA86620.1 - 0.11 12.2 0.1 1.3 8.7 0.1 2.1 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein VirC1 PF07015.11 EFA86620.1 - 0.15 11.3 0.2 0.32 10.3 0.1 1.5 2 0 0 2 2 2 0 VirC1 protein AAA_30 PF13604.6 EFA86620.1 - 0.2 11.4 0.1 0.36 10.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 EFA86621.1 - 3.1e-16 59.3 19.7 2.1e-15 56.5 19.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily RNB PF00773.19 EFA86622.1 - 6.5e-25 88.1 1.2 1.8e-24 86.7 1.2 1.8 1 0 0 1 1 1 1 RNB domain AAA_11 PF13086.6 EFA86622.1 - 1.2e-19 71.2 22.8 5e-10 39.6 0.1 4.3 3 1 1 4 4 4 2 AAA domain AAA_12 PF13087.6 EFA86622.1 - 2.6e-09 37.0 9.3 3.1e-09 36.7 0.5 3.0 2 0 0 2 2 2 1 AAA domain zf-CCCH PF00642.24 EFA86622.1 - 0.0033 17.3 2.5 0.0033 17.3 2.5 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_30 PF13604.6 EFA86622.1 - 0.0069 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFA86622.1 - 0.027 14.9 0.1 0.4 11.1 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF5599 PF18141.1 EFA86622.1 - 0.03 14.6 0.0 0.15 12.3 0.0 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5599) OB_Dis3 PF17849.1 EFA86622.1 - 0.092 12.8 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 Dis3-like cold-shock domain 2 (CSD2) Mpp10 PF04006.12 EFA86622.1 - 0.42 9.0 48.2 0.69 8.3 48.2 1.2 1 0 0 1 1 1 0 Mpp10 protein ILEI PF15711.5 EFA86622.1 - 0.48 10.9 4.3 2.3 8.7 0.1 3.2 2 1 1 3 3 3 0 Interleukin-like EMT inducer TPR_12 PF13424.6 EFA86624.1 - 0.11 12.9 0.1 6.6 7.1 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86624.1 - 0.75 10.1 7.3 11 6.4 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86624.1 - 0.85 9.6 10.8 1.6 8.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MACPF PF01823.19 EFA86625.1 - 0.13 12.3 14.2 0.45 10.6 7.0 2.3 1 1 1 2 2 2 0 MAC/Perforin domain Kdo PF06293.14 EFA86626.1 - 2.5e-12 46.6 0.0 5.8e-12 45.4 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFA86626.1 - 1.1e-10 41.4 1.2 1.3e-10 41.1 1.2 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EFA86626.1 - 1.2e-07 31.5 0.4 2.2e-07 30.7 0.2 1.4 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.17 EFA86626.1 - 2.9e-07 30.0 0.4 3.9e-07 29.6 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFA86626.1 - 3.4e-06 27.2 0.0 0.0074 16.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family EcKinase PF02958.20 EFA86626.1 - 0.00055 19.3 0.2 0.00069 19.0 0.2 1.3 1 1 0 1 1 1 1 Ecdysteroid kinase Kinase-like PF14531.6 EFA86626.1 - 0.0039 16.6 0.1 0.0054 16.1 0.1 1.3 1 0 0 1 1 1 1 Kinase-like APH_6_hur PF04655.14 EFA86626.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase zf-SNAP50_C PF12251.8 EFA86627.1 - 9.2e-62 208.3 7.8 1.7e-61 207.4 7.8 1.5 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Acetyltransf_10 PF13673.7 EFA86627.1 - 1.1e-13 51.3 0.0 2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFA86627.1 - 1.3e-12 47.9 0.0 2.9e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFA86627.1 - 3e-12 46.8 0.0 6e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFA86627.1 - 0.00011 22.1 0.0 0.00028 20.8 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFA86627.1 - 0.0079 16.3 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase P-mevalo_kinase PF04275.14 EFA86627.1 - 0.026 14.5 1.0 0.061 13.3 0.1 2.1 2 0 0 2 2 2 0 Phosphomevalonate kinase Acetyltransf_3 PF13302.7 EFA86627.1 - 0.07 13.8 0.0 0.12 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Mucin PF01456.17 EFA86627.1 - 1.4 8.9 14.6 2.3 8.2 14.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EFA86627.1 - 1.7 6.8 15.6 2.3 6.3 15.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Ecotin PF03974.13 EFA86628.1 - 2.9e-47 159.7 0.2 3.3e-47 159.5 0.2 1.0 1 0 0 1 1 1 1 Ecotin RasGEF PF00617.19 EFA86629.1 - 2.8e-51 174.2 0.8 1.7e-50 171.7 0.8 2.5 1 0 0 1 1 1 1 RasGEF domain RhoGAP PF00620.27 EFA86629.1 - 2.1e-09 37.4 1.0 1.3e-08 34.8 0.0 2.8 2 0 0 2 2 2 1 RhoGAP domain RasGEF_N PF00618.20 EFA86629.1 - 1.1e-08 35.3 3.9 1.1e-08 35.3 3.9 4.1 3 0 0 3 3 3 1 RasGEF N-terminal motif FNIP PF05725.12 EFA86630.1 - 1e-17 64.0 14.0 7.1e-05 22.9 0.8 7.9 3 2 8 11 11 11 9 FNIP Repeat YjgF_endoribonc PF14588.6 EFA86631.1 - 2.8e-26 92.4 0.0 3.3e-26 92.2 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 EFA86631.1 - 1.5e-14 54.1 0.0 2.3e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP DEAD PF00270.29 EFA86632.1 - 1.3e-49 168.3 0.0 3.2e-49 167.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFA86632.1 - 1.3e-27 96.3 0.0 7.4e-27 93.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFA86632.1 - 3.4e-07 30.4 1.3 1.3e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PHtD_u1 PF16645.5 EFA86632.1 - 0.022 15.2 6.7 2.3 8.7 1.2 3.0 2 0 0 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein Ribosomal_60s PF00428.19 EFA86632.1 - 0.078 13.6 2.5 0.21 12.2 2.5 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein ICAT PF06384.11 EFA86633.1 - 1.4e-32 111.8 1.5 1.4e-32 111.8 1.5 2.2 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT 5_3_exonuc PF01367.20 EFA86633.1 - 0.005 17.4 1.9 0.11 13.1 0.0 2.5 1 1 1 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold GvpG PF05120.12 EFA86633.1 - 0.0071 16.3 8.8 0.021 14.8 0.2 2.7 2 0 0 2 2 2 1 Gas vesicle protein G CAMP_factor PF07373.11 EFA86633.1 - 0.013 15.2 0.6 0.02 14.5 0.6 1.4 1 0 0 1 1 1 0 CAMP factor (Cfa) DUF3313 PF11769.8 EFA86633.1 - 0.019 14.8 0.1 0.046 13.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3313) TetR_C_7 PF14246.6 EFA86633.1 - 0.041 13.9 0.2 0.42 10.6 0.0 2.2 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain HCMV_UL139 PF12507.8 EFA86633.1 - 0.14 12.6 1.9 0.14 12.5 0.4 1.7 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein DUF2408 PF10303.9 EFA86633.1 - 1.2 9.7 7.9 0.46 11.1 4.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) SHOCT PF09851.9 EFA86633.1 - 1.3 8.9 6.5 1.8 8.4 1.8 3.3 2 1 0 2 2 2 0 Short C-terminal domain DUF883 PF05957.13 EFA86633.1 - 3.3 8.4 6.0 2.2 9.0 0.8 2.8 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) E1_DerP2_DerF2 PF02221.15 EFA86634.1 - 3.9e-22 79.1 0.1 4.3e-22 79.0 0.1 1.0 1 0 0 1 1 1 1 ML domain EB PF01683.18 EFA86635.1 - 1.7e-05 25.0 21.9 0.00022 21.4 5.6 10.8 5 4 6 11 11 11 7 EB module Dickkopf_N PF04706.12 EFA86635.1 - 0.0066 16.9 108.9 0.019 15.4 11.8 10.6 5 3 5 11 11 11 6 Dickkopf N-terminal cysteine-rich region EphA2_TM PF14575.6 EFA86636.1 - 3.4 8.6 5.5 9.9 7.1 0.1 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ricin_B_lectin PF00652.22 EFA86637.1 - 3.5e-10 40.2 8.4 0.00017 21.9 0.1 4.0 4 0 0 4 4 4 3 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EFA86637.1 - 9.1e-06 26.3 12.0 0.064 14.0 0.1 4.5 3 1 1 4 4 4 2 Ricin-type beta-trefoil lectin domain-like Endotoxin_N PF03945.14 EFA86637.1 - 1.1e-05 25.3 1.0 9e-05 22.3 1.0 2.2 1 1 0 1 1 1 1 delta endotoxin, N-terminal domain CDtoxinA PF03498.14 EFA86637.1 - 0.0001 21.9 4.1 0.072 12.7 0.1 3.6 2 1 1 3 3 3 2 Cytolethal distending toxin A/C domain Pentapeptide_4 PF13599.6 EFA86638.1 - 0.022 14.9 11.7 0.17 12.0 2.5 4.0 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFA86638.1 - 0.39 10.9 22.4 0.28 11.4 11.0 4.2 4 1 0 4 4 4 0 Pentapeptide repeats (9 copies) DNA_PPF PF02916.15 EFA86638.1 - 4.9 7.6 6.7 0.95 9.9 1.4 2.3 2 1 0 2 2 2 0 DNA polymerase processivity factor EB PF01683.18 EFA86640.1 - 0.00016 21.9 4.4 0.00016 21.9 4.4 7.1 2 1 4 7 7 7 6 EB module zf-B_box PF00643.24 EFA86641.1 - 0.098 12.8 8.5 0.17 12.0 8.5 1.4 1 0 0 1 1 1 0 B-box zinc finger RBFA PF02033.18 EFA86642.1 - 2.7e-08 34.2 6.3 0.0017 18.8 0.4 3.3 3 0 0 3 3 3 2 Ribosome-binding factor A Alpha_L_fucos PF01120.17 EFA86643.1 - 2.5e-116 388.9 2.7 3.3e-116 388.6 2.7 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EFA86643.1 - 3.9e-16 59.4 0.4 1e-15 58.0 0.1 1.9 2 0 0 2 2 2 1 Alpha-L-fucosidase C-terminal domain Phage_Treg PF04761.12 EFA86643.1 - 0.026 14.6 0.1 0.32 11.1 0.0 2.4 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator NOA36 PF06524.12 EFA86644.1 - 0.18 11.1 9.9 0.31 10.3 9.9 1.4 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EFA86644.1 - 0.22 11.2 10.3 0.37 10.5 10.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nucleo_P87 PF07267.11 EFA86644.1 - 0.23 10.3 9.9 0.37 9.6 9.9 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RXT2_N PF08595.11 EFA86644.1 - 0.89 9.6 8.4 0.41 10.7 5.4 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 EFA86644.1 - 1.5 9.2 10.8 0.69 10.3 8.0 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EFA86644.1 - 6.9 6.3 17.6 0.38 10.4 8.9 2.7 2 1 1 3 3 3 0 FAM176 family PPP4R2 PF09184.11 EFA86644.1 - 9.5 5.7 22.6 4.3 6.8 20.6 1.4 1 1 0 1 1 1 0 PPP4R2 UQ_con PF00179.26 EFA86646.1 - 4.4e-40 136.6 0.2 8.1e-40 135.7 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PPP4R2 PF09184.11 EFA86646.1 - 0.093 12.3 28.3 0.12 11.9 28.3 1.2 1 0 0 1 1 1 0 PPP4R2 Mucin PF01456.17 EFA86646.1 - 1.9 8.4 11.8 3 7.8 11.8 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Peptidase_S64 PF08192.11 EFA86646.1 - 3.5 6.0 20.2 4.5 5.6 20.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 SAC3_GANP PF03399.16 EFA86647.1 - 6.9e-76 255.4 5.1 1.7e-75 254.1 2.8 2.7 2 1 1 3 3 3 1 SAC3/GANP family RRM_1 PF00076.22 EFA86647.1 - 1.9e-05 24.4 0.0 5.8e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mic1 PF07035.12 EFA86648.1 - 4.1e-43 146.8 4.8 8.5e-43 145.8 4.8 1.5 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like NmrA PF05368.13 EFA86649.1 - 1.8e-26 93.1 0.0 2.2e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFA86649.1 - 0.00021 21.2 0.0 0.0003 20.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFA86649.1 - 0.0064 15.5 0.0 0.0085 15.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_23 PF13489.6 EFA86651.1 - 8.6e-13 48.5 0.1 2e-12 47.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA86651.1 - 2.7e-12 46.7 0.0 5.8e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA86651.1 - 5.7e-12 46.2 0.0 5.7e-12 46.2 0.0 2.9 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA86651.1 - 7.3e-12 45.8 0.0 4.3e-11 43.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA86651.1 - 1.1e-09 38.9 0.0 2.4e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFA86651.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Cyclin PF08613.11 EFA86651.1 - 0.14 12.5 3.1 0.43 10.9 2.0 2.1 2 0 0 2 2 2 0 Cyclin Mucin PF01456.17 EFA86651.1 - 1.3 9.0 13.0 2 8.4 13.0 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DNA_methylase PF00145.17 EFA86652.1 - 3.9e-35 121.8 1.8 5.2e-35 121.4 1.8 1.2 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase COG7 PF10191.9 EFA86654.1 - 1.6e-107 360.7 34.0 3.9e-77 260.2 21.6 3.4 1 1 1 2 2 2 2 Golgi complex component 7 (COG7) DUF2812 PF11193.8 EFA86654.1 - 0.089 13.0 1.3 0.32 11.2 1.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2812) RPW8 PF05659.11 EFA86654.1 - 0.17 11.6 4.3 1.1 8.9 0.2 3.1 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Raptor_N PF14538.6 EFA86654.1 - 0.95 9.4 9.4 0.11 12.4 2.8 3.0 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain BUD22 PF09073.10 EFA86655.1 - 7.6e-07 28.8 15.5 1e-06 28.4 15.5 1.3 1 0 0 1 1 1 1 BUD22 TFIIF_alpha PF05793.12 EFA86655.1 - 0.0003 19.5 16.1 0.00035 19.3 16.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Astro_capsid_p PF12226.8 EFA86655.1 - 0.00089 18.5 6.5 0.0012 18.0 6.5 1.3 1 0 0 1 1 1 1 Turkey astrovirus capsid protein TAF4 PF05236.14 EFA86655.1 - 0.0081 15.9 13.7 0.013 15.3 13.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF913 PF06025.12 EFA86655.1 - 0.013 14.5 6.0 0.019 13.9 6.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RP-C_C PF11800.8 EFA86655.1 - 0.015 15.4 8.4 0.015 15.4 8.4 1.4 2 0 0 2 2 1 0 Replication protein C C-terminal region CDC45 PF02724.14 EFA86655.1 - 0.023 13.0 11.2 0.025 12.9 11.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 EFA86655.1 - 0.042 12.9 20.3 0.074 12.0 20.3 1.4 1 0 0 1 1 1 0 Paf1 DDHD PF02862.17 EFA86655.1 - 0.074 13.2 5.3 0.1 12.8 5.3 1.3 1 0 0 1 1 1 0 DDHD domain Peptidase_S49_N PF08496.10 EFA86655.1 - 0.075 13.1 12.2 0.15 12.1 12.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF1682 PF07946.14 EFA86655.1 - 0.097 11.9 18.4 0.12 11.6 18.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNA_pol_3_Rpc31 PF11705.8 EFA86655.1 - 0.12 12.6 18.5 0.2 11.9 18.5 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4820 PF16091.5 EFA86655.1 - 0.14 11.5 7.9 0.22 10.9 7.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PPL5 PF18168.1 EFA86655.1 - 0.19 11.0 9.6 0.29 10.4 9.6 1.4 1 0 0 1 1 1 0 Prim-pol family 5 DUF2052 PF09747.9 EFA86655.1 - 0.22 11.6 20.2 0.063 13.4 16.2 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Vfa1 PF08432.10 EFA86655.1 - 0.35 11.2 25.0 0.018 15.4 19.8 1.5 2 0 0 2 2 1 0 AAA-ATPase Vps4-associated protein 1 Tim54 PF11711.8 EFA86655.1 - 0.37 9.5 14.9 0.57 8.9 14.9 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 GAGA_bind PF06217.12 EFA86655.1 - 0.49 10.6 12.3 0.54 10.5 12.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF5308 PF17233.2 EFA86655.1 - 0.51 10.5 2.7 0.86 9.8 2.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Ureide_permease PF07168.11 EFA86655.1 - 0.58 8.8 5.4 0.76 8.5 5.4 1.3 1 0 0 1 1 1 0 Ureide permease DNA_pol_phi PF04931.13 EFA86655.1 - 0.59 8.2 19.1 0.76 7.8 19.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Adaptin_binding PF10199.9 EFA86655.1 - 0.6 10.7 16.6 1.3 9.7 13.0 2.2 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Serinc PF03348.15 EFA86655.1 - 0.66 8.8 4.3 0.8 8.6 4.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) AAA_11 PF13086.6 EFA86655.1 - 0.71 9.6 10.8 0.9 9.3 10.8 1.2 1 0 0 1 1 1 0 AAA domain RRN3 PF05327.11 EFA86655.1 - 0.72 8.3 10.4 1.1 7.7 10.4 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BORG_CEP PF14957.6 EFA86655.1 - 0.76 10.9 7.2 0.19 12.9 4.4 1.7 2 0 0 2 2 1 0 Cdc42 effector DDRGK PF09756.9 EFA86655.1 - 0.84 9.2 30.5 0.45 10.1 27.1 2.1 2 0 0 2 2 2 0 DDRGK domain DUF4407 PF14362.6 EFA86655.1 - 1.7 7.9 3.7 2.1 7.6 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FYDLN_acid PF09538.10 EFA86655.1 - 2 9.1 18.3 0.33 11.6 12.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF4746 PF15928.5 EFA86655.1 - 2.4 7.5 22.1 4.4 6.6 22.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NPR3 PF03666.13 EFA86655.1 - 2.5 6.8 14.8 3.5 6.3 14.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Paramyxo_ncap PF00973.19 EFA86655.1 - 2.7 6.8 7.2 3.4 6.5 7.2 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Connexin PF00029.19 EFA86655.1 - 2.9 7.6 16.6 5.4 6.7 16.6 1.4 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 EFA86655.1 - 3.7 6.3 10.4 4.5 6.0 10.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SID-1_RNA_chan PF13965.6 EFA86655.1 - 5.9 5.2 6.6 6.5 5.0 6.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TRAP_alpha PF03896.16 EFA86655.1 - 6.5 5.9 16.0 0.49 9.6 10.9 1.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit RR_TM4-6 PF06459.12 EFA86655.1 - 9.4 6.0 26.8 13 5.6 26.8 1.4 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 NUDIX PF00293.28 EFA86656.1 - 6.1e-10 39.2 0.1 1e-09 38.5 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain EB PF01683.18 EFA86656.1 - 0.0032 17.7 5.1 0.0032 17.7 5.1 6.9 3 3 4 7 7 7 4 EB module ketoacyl-synt PF00109.26 EFA86658.1 - 5e-67 226.1 0.0 1.2e-66 224.9 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFA86658.1 - 1.6e-53 182.3 0.0 2.4e-53 181.7 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFA86658.1 - 4.8e-37 126.6 0.2 1e-36 125.5 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFA86658.1 - 8.9e-35 120.2 0.0 3.7e-34 118.2 0.0 2.0 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFA86658.1 - 1.3e-31 110.0 0.0 2.3e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFA86658.1 - 7e-19 68.3 0.0 1.7e-18 67.1 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFA86658.1 - 7.3e-16 58.7 0.0 2.5e-15 57.0 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFA86658.1 - 4.3e-11 42.6 0.0 9.6e-09 35.0 0.0 2.7 3 0 0 3 3 3 1 short chain dehydrogenase Methyltransf_23 PF13489.6 EFA86658.1 - 5.3e-11 42.6 0.0 1.3e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EFA86658.1 - 2.4e-09 37.2 0.0 8.2e-09 35.5 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFA86658.1 - 4.6e-08 34.2 0.0 1.6e-07 32.4 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFA86658.1 - 7.4e-08 32.2 0.0 2.6e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFA86658.1 - 8.6e-08 32.1 0.0 3.3e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFA86658.1 - 1.1e-06 29.3 0.0 7.4e-06 26.6 0.0 2.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA86658.1 - 2.2e-05 25.0 0.0 0.00012 22.6 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EFA86658.1 - 3.6e-05 23.6 0.0 9.7e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_16 PF10294.9 EFA86658.1 - 0.00042 20.1 0.0 0.0024 17.6 0.0 2.2 2 0 0 2 2 2 1 Lysine methyltransferase Thiolase_N PF00108.23 EFA86658.1 - 0.015 14.6 0.1 0.085 12.2 0.1 2.2 3 0 0 3 3 3 0 Thiolase, N-terminal domain DUF5042 PF16445.5 EFA86658.1 - 0.021 13.3 0.1 0.036 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5042) 3Beta_HSD PF01073.19 EFA86658.1 - 0.051 12.6 0.0 0.097 11.7 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EFA86658.1 - 0.11 12.9 0.0 0.36 11.2 0.0 2.0 1 0 0 1 1 1 0 Phosphopantetheine attachment site RXLR PF16810.5 EFA86659.1 - 0.036 14.5 0.2 0.036 14.5 0.2 4.1 2 1 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity FlxA PF14282.6 EFA86661.1 - 0.0041 17.1 0.0 0.006 16.5 0.0 1.2 1 0 0 1 1 1 1 FlxA-like protein DUF3138 PF11336.8 EFA86661.1 - 0.023 13.3 0.0 0.026 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) FlxA PF14282.6 EFA86662.1 - 0.0065 16.4 0.1 0.0095 15.9 0.1 1.2 1 0 0 1 1 1 1 FlxA-like protein PfkB PF00294.24 EFA86664.1 - 1e-08 34.9 0.0 1.7e-07 30.9 0.0 2.4 2 0 0 2 2 2 1 pfkB family carbohydrate kinase DDHD PF02862.17 EFA86664.1 - 0.26 11.4 7.6 1.5 9.0 7.4 1.9 2 0 0 2 2 2 0 DDHD domain DUF1635 PF07795.11 EFA86664.1 - 3.9 7.3 10.9 7.6 6.3 10.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) MFS_MOT1 PF16983.5 EFA86666.1 - 0.02 15.3 2.3 0.02 15.3 2.3 4.1 4 2 1 5 5 5 0 Molybdate transporter of MFS superfamily RhoGAP PF00620.27 EFA86667.1 - 5e-33 114.1 0.0 7.5e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain ATG_C PF09333.11 EFA86667.1 - 7.3e-09 35.9 0.2 3.3e-08 33.8 0.1 2.0 1 1 1 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EFA86667.1 - 0.0077 16.0 2.0 0.019 14.8 1.2 2.0 1 1 1 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal Senescence PF06911.12 EFA86667.1 - 0.033 14.5 0.2 0.08 13.3 0.2 1.6 1 0 0 1 1 1 0 Senescence-associated protein Antimicrobial_2 PF08023.12 EFA86667.1 - 0.23 12.0 2.5 0.57 10.8 2.5 1.7 1 0 0 1 1 1 0 Frog antimicrobial peptide DUF885 PF05960.11 EFA86668.1 - 3.1e-57 195.4 0.0 2.3e-34 120.0 0.0 2.7 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF885) His_Phos_1 PF00300.22 EFA86670.1 - 2e-29 102.6 0.5 3.9e-29 101.7 0.5 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AstB PF04996.12 EFA86670.1 - 0.24 10.0 2.3 0.36 9.5 2.3 1.2 1 0 0 1 1 1 0 Succinylarginine dihydrolase UCH PF00443.29 EFA86672.1 - 5.6e-30 104.7 3.9 5.6e-30 104.7 3.9 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFA86672.1 - 7.3e-13 48.6 5.2 1.3e-12 47.8 5.2 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EFA86672.1 - 0.1 12.4 3.2 0.19 11.5 3.2 1.5 1 0 0 1 1 1 0 Variant UBP zinc finger UCH_1 PF13423.6 EFA86672.1 - 0.16 11.5 4.0 0.29 10.7 2.4 2.0 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase CCDC53 PF10152.9 EFA86672.1 - 0.67 10.4 10.3 4.9 7.6 0.2 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex dNK PF01712.19 EFA86673.1 - 5.5e-45 153.7 0.1 7.6e-45 153.3 0.1 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EFA86673.1 - 2.9e-05 23.8 0.0 6.3e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 EFA86673.1 - 0.0039 17.7 0.2 0.032 14.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 EFA86673.1 - 0.0041 17.1 0.0 0.017 15.1 0.0 1.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFA86673.1 - 0.009 16.3 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain RGS PF00615.19 EFA86674.1 - 1.2e-21 77.2 0.3 3.3e-21 75.8 0.3 1.7 1 1 0 1 1 1 1 Regulator of G protein signaling domain CLU PF13236.6 EFA86675.1 - 1.3e-61 208.2 0.0 2.8e-61 207.2 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria Menin PF05053.13 EFA86675.1 - 1.3 7.2 19.1 0.0056 15.1 5.4 2.3 2 0 0 2 2 2 0 Menin RIFIN PF02009.16 EFA86675.1 - 7.8 6.3 20.0 1.7 8.5 3.8 2.3 2 0 0 2 2 2 0 Rifin Oxidored_molyb PF00174.19 EFA86676.1 - 1.4e-58 197.3 0.0 2.8e-58 196.4 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EFA86676.1 - 3.3e-34 117.9 0.1 6.6e-34 116.9 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain eIF3_p135 PF12807.7 EFA86676.1 - 1.6e-07 31.5 0.2 5.5e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 RebB PF11747.8 EFA86676.1 - 1.2 9.2 3.4 2.2 8.4 3.4 1.3 1 0 0 1 1 1 0 Killing trait WWE PF02825.20 EFA86677.1 - 1.8e-16 60.5 8.1 5.3e-08 33.3 0.4 3.6 3 0 0 3 3 3 2 WWE domain zf-CCHH PF10283.9 EFA86677.1 - 1.7e-12 47.1 5.8 3.3e-12 46.1 5.8 1.5 1 0 0 1 1 1 1 PBZ domain BRCT PF00533.26 EFA86677.1 - 1.3e-11 44.7 0.0 3.8e-11 43.2 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PARP PF00644.20 EFA86677.1 - 1.4e-10 41.1 5.6 1.8e-10 40.8 0.3 3.0 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PTCB-BRCT PF12738.7 EFA86677.1 - 1.6e-06 28.0 1.0 4.6e-06 26.5 1.0 1.9 1 0 0 1 1 1 1 twin BRCT domain BRCT_3 PF18428.1 EFA86677.1 - 0.001 19.1 0.0 0.003 17.6 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFA86677.1 - 0.0013 19.1 1.3 0.0034 17.7 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFA86677.1 - 0.0098 16.2 0.1 0.028 14.7 0.1 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain Voldacs PF03517.13 EFA86678.1 - 3.5e-22 79.0 13.8 2.2e-21 76.4 13.8 2.1 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling FAINT PF04385.15 EFA86678.1 - 0.038 14.0 0.3 0.13 12.4 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function, DUF529 Vps36_ESCRT-II PF11605.8 EFA86678.1 - 0.043 14.0 0.0 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 WD40 PF00400.32 EFA86679.1 - 0.00017 22.3 1.8 0.79 10.7 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat HARP PF07443.13 EFA86679.1 - 0.033 13.8 1.1 0.1 12.2 0.0 2.5 3 0 0 3 3 3 0 HepA-related protein (HARP) PS_Dcarbxylase PF02666.15 EFA86680.1 - 1.5e-58 197.6 0.0 3.1e-58 196.6 0.0 1.5 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase C2 PF00168.30 EFA86680.1 - 9e-25 87.0 0.2 2.1e-24 85.8 0.2 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_5 PF13202.6 EFA86680.1 - 7.6e-06 25.2 0.1 2.1e-05 23.8 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EFA86680.1 - 0.00018 21.9 0.1 0.0006 20.2 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFA86680.1 - 0.00043 19.6 0.2 0.0013 18.1 0.2 1.9 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EFA86680.1 - 0.0031 17.3 0.0 0.0079 16.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFA86680.1 - 0.0053 16.6 0.3 0.027 14.4 0.3 2.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_10 PF14788.6 EFA86680.1 - 0.028 14.3 0.1 0.028 14.3 0.1 2.9 3 0 0 3 3 3 0 EF hand Mucin PF01456.17 EFA86680.1 - 0.035 14.1 10.2 0.06 13.3 10.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DSPc PF00782.20 EFA86681.1 - 5.4e-30 103.9 0.0 3.4e-29 101.3 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EFA86681.1 - 4.1e-21 74.5 25.0 6.1e-10 38.7 2.1 4.8 3 1 2 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 EFA86681.1 - 3.6e-14 52.7 21.9 1.6e-06 28.4 0.8 5.9 5 1 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFA86681.1 - 3.2e-07 30.0 4.1 0.001 18.6 0.6 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EFA86681.1 - 0.00013 21.9 13.3 0.0045 17.0 2.3 3.2 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) Y_phosphatase PF00102.27 EFA86681.1 - 0.00051 19.7 0.1 0.0045 16.6 0.0 2.3 2 0 0 2 2 2 1 Protein-tyrosine phosphatase LRR_1 PF00560.33 EFA86681.1 - 0.017 15.6 20.9 9.5 7.2 0.1 8.1 8 0 0 8 8 8 0 Leucine Rich Repeat MtN3_slv PF03083.16 EFA86682.1 - 3.1e-35 120.1 12.8 6.8e-19 67.7 0.6 2.4 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange DUF1771 PF08590.10 EFA86682.1 - 1.4e-18 67.0 4.7 1.4e-18 67.0 4.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EFA86682.1 - 0.00096 19.5 0.0 0.0022 18.3 0.0 1.7 1 0 0 1 1 1 1 Smr domain TFIIA PF03153.13 EFA86682.1 - 1.5 8.7 28.7 2.4 8.1 28.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1771 PF08590.10 EFA86683.1 - 2.1e-19 69.6 4.5 4.8e-19 68.5 4.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) zf-CCCH_3 PF15663.5 EFA86683.1 - 8.8e-06 25.9 1.2 8.8e-06 25.9 1.2 2.4 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH PF00642.24 EFA86683.1 - 0.00099 19.0 10.8 0.01 15.7 1.5 2.8 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFA86683.1 - 0.001 19.5 4.6 0.001 19.5 4.6 2.8 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger CAC1F_C PF16885.5 EFA86683.1 - 0.18 11.4 14.8 1.8 8.2 0.1 2.3 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term Calpain_inhib PF00748.19 EFA86683.1 - 2.4 8.6 9.4 6.5 7.3 9.4 1.7 1 0 0 1 1 1 0 Calpain inhibitor zf_CCCH_4 PF18345.1 EFA86683.1 - 2.7 8.2 10.5 1.4 9.1 0.6 3.5 3 1 0 3 3 3 0 Zinc finger domain Macoilin PF09726.9 EFA86683.1 - 4.9 5.6 33.2 0.18 10.3 20.5 2.1 2 0 0 2 2 2 0 Macoilin family SdrD_B PF17210.3 EFA86684.1 - 1.4e-05 25.3 0.0 0.00087 19.5 0.0 4.0 2 0 0 2 2 2 1 SdrD B-like domain Pkinase PF00069.25 EFA86685.1 - 9.2e-64 215.3 0.8 3.5e-63 213.4 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86685.1 - 1.7e-44 152.1 0.0 4.3e-44 150.7 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Ctr PF04145.15 EFA86685.1 - 4e-08 34.0 13.1 4e-08 34.0 13.1 5.7 2 2 0 2 2 2 1 Ctr copper transporter family APH PF01636.23 EFA86685.1 - 0.029 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1465 PF07323.12 EFA86685.1 - 5.7 6.8 7.5 3.2 7.6 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) TIG PF01833.24 EFA86686.1 - 1.1e-07 31.8 3.6 1.1e-07 31.8 3.6 8.3 8 1 1 9 9 9 4 IPT/TIG domain EGF_2 PF07974.13 EFA86686.1 - 0.033 14.6 13.6 0.076 13.4 13.6 1.6 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 EFA86686.1 - 0.082 13.1 5.8 0.17 12.1 5.8 1.5 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 EFA86686.1 - 1.6 9.5 7.2 6.7 7.5 7.2 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF FA_desaturase PF00487.24 EFA86687.1 - 1.1e-17 64.7 17.8 1.1e-16 61.5 17.8 2.0 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EFA86687.1 - 1.4e-09 38.3 0.0 3.5e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Sensor PF13796.6 EFA86687.1 - 0.029 14.4 0.2 0.11 12.5 0.3 1.9 1 1 0 1 1 1 0 Putative sensor PIP5K PF01504.18 EFA86688.1 - 2.9e-33 115.3 2.1 6.4e-31 107.6 0.7 3.7 3 1 1 4 4 4 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EFA86688.1 - 4.4e-22 78.4 0.5 8.4e-22 77.4 0.5 1.4 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EFA86688.1 - 4.7e-17 61.9 13.0 1.4e-16 60.4 13.0 1.9 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 EFA86688.1 - 0.022 15.0 9.4 0.014 15.6 4.9 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger DUF1084 PF06454.11 EFA86689.1 - 4.1e-14 52.6 19.4 5.3e-14 52.2 19.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) DUF1129 PF06570.11 EFA86689.1 - 0.015 14.8 0.3 0.015 14.8 0.3 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1129) TRAM1 PF08390.11 EFA86689.1 - 0.15 11.8 5.0 8.3 6.2 1.1 3.1 2 0 0 2 2 2 0 TRAM1-like protein DUF4131 PF13567.6 EFA86689.1 - 4 7.1 10.9 3.1 7.4 1.6 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) Glyco_hydro_57 PF03065.15 EFA86690.1 - 2.2e-07 30.4 0.0 3.1e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 RUN PF02759.19 EFA86691.1 - 3.4e-07 30.3 0.6 1.3e-06 28.4 0.3 2.2 2 0 0 2 2 2 1 RUN domain CDC50 PF03381.15 EFA86692.1 - 1.4e-90 303.6 1.0 1.7e-90 303.4 0.5 1.4 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Pkinase PF00069.25 EFA86693.1 - 8.6e-75 251.5 0.0 2e-74 250.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86693.1 - 3.6e-49 167.4 0.0 6.2e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFA86693.1 - 1.1e-06 27.8 0.4 3e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase V-ATPase_H_C PF11698.8 EFA86693.1 - 0.00045 20.3 2.5 0.0016 18.6 2.5 2.0 1 0 0 1 1 1 1 V-ATPase subunit H Kinase-like PF14531.6 EFA86693.1 - 0.0011 18.3 0.0 0.017 14.5 0.0 2.4 2 0 0 2 2 2 1 Kinase-like RICTOR_N PF14664.6 EFA86693.1 - 0.002 17.2 1.4 0.99 8.3 0.1 3.9 3 1 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, N-term Arm PF00514.23 EFA86693.1 - 0.0035 17.3 1.7 9.8 6.4 0.0 5.4 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat ParcG PF10274.9 EFA86693.1 - 0.0053 16.9 1.0 0.016 15.3 1.0 1.8 1 0 0 1 1 1 1 Parkin co-regulated protein RIO1 PF01163.22 EFA86693.1 - 0.024 14.2 0.0 0.053 13.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EFA86693.1 - 0.042 13.5 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFA86693.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HNF-1_N PF04814.13 EFA86693.1 - 3.1 8.4 12.4 0.17 12.5 6.0 2.1 1 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Oxysterol_BP PF01237.18 EFA86694.1 - 2e-48 165.1 8.3 1.4e-44 152.4 1.3 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein DUF1084 PF06454.11 EFA86695.1 - 4.9e-06 26.1 13.1 0.0016 17.9 0.6 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1084) DUF4257 PF14074.6 EFA86695.1 - 0.34 11.2 3.0 2.7 8.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4257) WD40 PF00400.32 EFA86696.1 - 1.3e-15 57.5 10.5 0.0014 19.4 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat F-box-like PF12937.7 EFA86696.1 - 5e-10 39.1 1.3 1.3e-09 37.8 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFA86696.1 - 1e-08 34.8 1.3 1.7e-08 34.1 0.3 2.0 2 0 0 2 2 2 1 F-box domain START PF01852.19 EFA86696.1 - 0.00066 19.2 0.0 0.0031 17.0 0.0 2.2 1 0 0 1 1 1 1 START domain Methyltransf_5 PF01795.19 EFA86697.1 - 1.7e-81 274.2 0.8 7.5e-81 272.0 0.0 2.2 2 1 0 2 2 2 1 MraW methylase family RGI1 PF10843.8 EFA86697.1 - 0.02 14.6 0.5 0.047 13.3 0.5 1.6 1 0 0 1 1 1 0 Respiratory growth induced protein 1 DUF4248 PF14053.6 EFA86697.1 - 0.052 13.6 0.1 0.16 12.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) EMC3_TMCO1 PF01956.16 EFA86697.1 - 0.4 10.4 6.3 6.6 6.4 0.3 2.8 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like OmpH PF03938.14 EFA86697.1 - 0.42 10.9 27.3 1.5 9.1 2.9 2.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Toxin_8 PF07365.12 EFA86700.1 - 0.0034 17.5 0.2 0.21 11.8 0.4 2.3 2 0 0 2 2 2 1 Alpha conotoxin precursor TRAF_BIRC3_bd PF16673.5 EFA86700.1 - 0.013 15.3 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain RCC1 PF00415.18 EFA86701.1 - 1.7e-50 169.4 6.4 1.2e-12 48.3 0.0 5.0 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFA86701.1 - 2.2e-37 126.1 16.1 9.8e-09 34.8 3.0 5.2 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat Nop53 PF07767.11 EFA86702.1 - 4.4e-32 112.0 51.2 5.5e-32 111.6 51.2 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Tetraspanin PF00335.20 EFA86703.1 - 0.0058 16.4 11.7 0.0058 16.4 11.7 2.3 1 1 1 2 2 2 1 Tetraspanin family YfhO PF09586.10 EFA86703.1 - 0.41 8.8 8.5 0.45 8.7 8.5 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CbiQ PF02361.16 EFA86703.1 - 2.3 7.8 14.2 2.8 7.5 14.2 1.1 1 0 0 1 1 1 0 Cobalt transport protein DUF2367 PF10164.9 EFA86703.1 - 9.2 6.8 8.1 36 4.9 4.8 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) SapB_2 PF03489.17 EFA86704.1 - 0.011 15.9 0.0 0.03 14.4 0.0 1.8 1 0 0 1 1 1 0 Saposin-like type B, region 2 CTXphi_pIII-N1 PF16710.5 EFA86704.1 - 0.037 14.1 2.4 0.4 10.8 0.3 2.1 1 1 0 2 2 2 0 N-terminal N1 domain of Vibrio phage CTXphi pIII SapB_1 PF05184.15 EFA86704.1 - 0.061 13.4 1.3 0.065 13.3 0.2 1.7 2 0 0 2 2 2 0 Saposin-like type B, region 1 Rad21_Rec8_N PF04825.13 EFA86705.1 - 6.6e-36 122.8 0.0 1.6e-35 121.6 0.0 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EFA86705.1 - 1.2e-13 50.1 0.2 1.4e-12 46.6 0.2 2.3 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 EFA86705.1 - 0.0055 16.6 0.5 0.016 15.2 0.0 2.1 2 0 0 2 2 2 1 Segregation and condensation protein ScpA Caudo_bapla_RBP PF08931.10 EFA86705.1 - 0.066 12.7 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head Ras PF00071.22 EFA86706.1 - 1.2e-60 203.8 0.6 1.4e-60 203.5 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86706.1 - 8.7e-35 119.5 0.2 1.6e-34 118.7 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFA86706.1 - 1.3e-14 54.1 0.2 1.6e-14 53.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFA86706.1 - 1.8e-06 28.0 0.1 2.5e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFA86706.1 - 6.2e-05 23.0 0.1 0.074 13.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EFA86706.1 - 0.00021 20.7 0.1 0.00033 20.2 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EFA86706.1 - 0.0048 16.6 0.2 0.014 15.1 0.1 1.7 2 0 0 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 EFA86706.1 - 0.0072 15.7 0.1 0.0096 15.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 EFA86706.1 - 0.0076 15.7 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 EFA86706.1 - 0.012 16.0 0.0 0.021 15.2 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EFA86706.1 - 0.038 13.3 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Septin Hexokinase_2 PF03727.16 EFA86706.1 - 0.051 13.0 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Hexokinase ATPase_2 PF01637.18 EFA86706.1 - 0.065 13.1 0.2 0.29 11.0 0.2 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFA86706.1 - 0.078 13.3 0.1 0.3 11.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFA86706.1 - 0.14 12.6 0.6 0.35 11.4 0.6 1.8 1 1 0 1 1 1 0 ABC transporter GIT_SHD PF08518.11 EFA86706.1 - 0.25 11.0 0.7 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT CENP-T_C PF15511.6 EFA86709.1 - 1.6e-08 34.6 0.0 2e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EFA86709.1 - 3.7e-05 23.8 0.0 5.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFA86709.1 - 0.00021 21.5 0.0 0.00034 20.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFA86709.1 - 0.0007 19.9 0.2 0.00094 19.5 0.2 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EFA86709.1 - 0.001 19.4 0.2 0.0012 19.2 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EFA86709.1 - 0.0023 18.0 0.0 0.0028 17.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFA86709.1 - 0.0061 16.6 0.1 0.011 15.7 0.1 1.5 1 1 1 2 2 2 1 Bromodomain associated HATPase_c_3 PF13589.6 EFA86710.1 - 5.8e-18 65.0 1.0 5.8e-18 65.0 1.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFA86710.1 - 3.5e-06 27.5 0.1 1.3e-05 25.6 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EMP24_GP25L PF01105.24 EFA86710.1 - 0.024 14.6 6.9 0.042 13.8 0.9 3.5 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD APG6_N PF17675.1 EFA86710.1 - 0.77 10.3 8.3 0.53 10.8 2.0 2.7 2 0 0 2 2 2 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 EFA86710.1 - 4.1 7.7 12.9 1.7 8.9 5.1 2.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Filament PF00038.21 EFA86710.1 - 4.1 6.9 12.0 0.35 10.4 5.0 2.3 2 0 0 2 2 2 0 Intermediate filament protein KxDL PF10241.9 EFA86710.1 - 5.9 7.2 7.1 0.4 11.0 1.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein Prefoldin PF02996.17 EFA86710.1 - 7.6 6.5 7.6 0.29 11.1 0.6 2.3 2 0 0 2 2 2 0 Prefoldin subunit SapB_2 PF03489.17 EFA86711.1 - 0.016 15.3 0.3 0.17 12.0 0.0 2.3 2 0 0 2 2 2 0 Saposin-like type B, region 2 SapB_1 PF05184.15 EFA86711.1 - 0.74 9.9 9.2 2.1 8.4 3.1 2.7 2 0 0 2 2 2 0 Saposin-like type B, region 1 CDC45 PF02724.14 EFA86714.1 - 0.00074 17.9 9.6 0.00074 17.9 9.6 2.9 3 0 0 3 3 3 1 CDC45-like protein Pox_Ag35 PF03286.14 EFA86714.1 - 0.0097 15.7 15.3 0.0097 15.7 15.3 3.1 3 0 0 3 3 3 1 Pox virus Ag35 surface protein Cnd1 PF12717.7 EFA86714.1 - 1.6 8.8 9.0 0.28 11.2 0.4 4.1 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 BUD22 PF09073.10 EFA86714.1 - 7.9 5.7 39.4 0.0073 15.7 18.0 3.0 3 0 0 3 3 3 0 BUD22 Tubulin PF00091.25 EFA86716.1 - 6.9e-36 124.3 0.4 2.6e-35 122.4 0.0 2.1 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFA86716.1 - 4.1e-26 91.6 0.0 1.4e-25 89.8 0.0 2.1 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF3605 PF12239.8 EFA86716.1 - 1.6e-15 57.7 2.3 1.6e-15 57.7 2.3 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF3605) SUV3_C PF12513.8 EFA86716.1 - 0.14 12.1 0.1 0.41 10.6 0.1 1.8 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal AIG1 PF04548.16 EFA86717.1 - 2.1e-13 50.1 1.2 3.5e-13 49.4 1.2 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EFA86717.1 - 7.2e-07 29.3 1.1 2.2e-06 27.8 0.3 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFA86717.1 - 0.00055 19.4 0.2 0.00079 18.8 0.2 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region T2SSE PF00437.20 EFA86717.1 - 0.0061 15.7 0.1 0.013 14.6 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF87 PF01935.17 EFA86717.1 - 0.012 15.7 0.4 0.012 15.7 0.4 1.9 2 1 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EFA86717.1 - 0.014 15.3 1.1 0.031 14.2 0.5 1.9 1 1 1 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EFA86717.1 - 0.021 15.3 2.4 0.038 14.5 2.4 1.9 1 1 0 1 1 1 0 ABC transporter Septin PF00735.18 EFA86717.1 - 0.022 14.0 0.6 0.022 14.0 0.6 2.3 2 1 0 3 3 3 0 Septin G-alpha PF00503.20 EFA86717.1 - 0.029 13.5 1.2 0.04 13.1 1.2 1.4 1 1 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 EFA86717.1 - 0.036 13.8 0.3 0.067 12.9 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFA86717.1 - 0.037 13.3 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EFA86717.1 - 0.043 13.5 0.7 0.064 13.0 0.1 1.7 2 0 0 2 2 2 0 AAA domain AP1AR PF15745.5 EFA86717.1 - 0.052 13.2 2.3 0.083 12.5 2.3 1.3 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein FtsK_SpoIIIE PF01580.18 EFA86717.1 - 0.062 12.6 0.8 0.083 12.2 0.1 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EFA86717.1 - 0.091 13.0 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFA86717.1 - 0.27 11.8 5.1 0.24 11.9 1.7 2.5 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFA86717.1 - 0.81 9.7 7.9 0.4 10.7 0.4 2.9 2 1 1 3 3 3 0 Dynamin family AAA_23 PF13476.6 EFA86717.1 - 5.3 7.5 16.4 27 5.2 16.4 1.9 1 1 0 1 1 1 0 AAA domain CHD5 PF04420.14 EFA86718.1 - 0.1 12.5 0.1 0.1 12.5 0.1 3.0 3 0 0 3 3 3 0 CHD5-like protein PBP1_TM PF14812.6 EFA86718.1 - 8.4 6.8 8.0 0.33 11.3 1.2 2.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IBR PF01485.21 EFA86719.1 - 8.9e-14 51.5 33.8 6.9e-09 35.8 10.4 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 EFA86719.1 - 0.019 14.8 9.3 0.019 14.8 9.3 5.0 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Chordopox_A15 PF05846.12 EFA86720.1 - 0.19 12.0 0.1 0.19 12.0 0.1 3.7 3 1 1 4 4 4 0 Chordopoxvirus A15 protein FNIP PF05725.12 EFA86721.1 - 4.6e-14 52.3 0.1 2e-06 27.8 0.0 2.8 2 0 0 2 2 2 2 FNIP Repeat RE_ScaI PF09569.10 EFA86721.1 - 0.0011 18.7 1.2 0.0016 18.2 1.2 1.3 1 0 0 1 1 1 1 ScaI restriction endonuclease F-box PF00646.33 EFA86721.1 - 0.0012 18.6 0.2 0.0035 17.2 0.2 1.8 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EFA86721.1 - 0.014 15.0 0.1 0.035 13.7 0.0 1.8 2 0 0 2 2 2 0 F-box F-box-like PF12937.7 EFA86721.1 - 0.016 15.1 0.4 0.044 13.7 0.1 1.9 2 0 0 2 2 2 0 F-box-like SR-25 PF10500.9 EFA86721.1 - 1.8 8.1 8.7 2.4 7.7 8.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WD40 PF00400.32 EFA86722.1 - 2.4e-13 50.3 11.1 4.4e-05 24.1 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat HEAT PF02985.22 EFA86722.1 - 1.3e-06 28.2 0.2 0.15 12.4 0.1 4.9 5 0 0 5 5 5 2 HEAT repeat Ge1_WD40 PF16529.5 EFA86722.1 - 0.0085 15.1 0.1 0.028 13.4 0.1 1.9 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein HEAT_2 PF13646.6 EFA86722.1 - 0.012 16.0 0.0 5.7 7.4 0.0 3.2 2 1 2 4 4 4 0 HEAT repeats Coiled PF05710.12 EFA86725.1 - 3.6e-15 56.6 14.0 4.8e-15 56.1 14.0 1.2 1 0 0 1 1 1 1 Coiled coil CLU PF13236.6 EFA86726.1 - 1.2e-60 205.1 0.0 2.3e-60 204.2 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFA86726.1 - 3e-06 27.4 4.6 1e-05 25.7 0.0 2.9 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 TPR_14 PF13428.6 EFA86726.1 - 0.12 13.3 0.0 0.32 11.9 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Methyltransf_25 PF13649.6 EFA86727.1 - 3.7e-10 40.4 0.0 9.1e-10 39.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 EFA86727.1 - 4.2e-10 39.5 0.0 7.8e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EFA86727.1 - 1.3e-09 38.2 0.0 2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFA86727.1 - 1.1e-08 35.7 0.0 4e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFA86727.1 - 8.3e-07 29.7 0.5 5.7e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFA86727.1 - 5e-06 26.4 0.0 1.5e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFA86727.1 - 6.4e-06 25.8 0.1 5e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain PRMT5 PF05185.16 EFA86727.1 - 3.5e-05 23.7 0.5 6.5e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 EFA86727.1 - 0.00039 20.2 0.1 0.00075 19.3 0.1 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_16 PF10294.9 EFA86727.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 EFA86727.1 - 0.0012 18.2 0.0 0.003 16.9 0.0 1.7 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G Cons_hypoth95 PF03602.15 EFA86727.1 - 0.061 13.0 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PALP PF00291.25 EFA86727.1 - 0.073 12.5 0.0 0.098 12.0 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme RrnaAD PF00398.20 EFA86727.1 - 0.1 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.7 EFA86727.1 - 0.11 12.5 0.1 0.22 11.4 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 EFA86727.1 - 0.15 13.1 0.0 0.69 11.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Laminin_EGF PF00053.24 EFA86729.1 - 0.0035 17.5 17.8 0.036 14.2 1.9 2.6 2 0 0 2 2 2 2 Laminin EGF domain EGF_Tenascin PF18720.1 EFA86729.1 - 0.1 12.6 0.4 0.1 12.6 0.4 2.7 2 0 0 2 2 2 0 Tenascin EGF domain RasGEF PF00617.19 EFA86730.1 - 7.8e-51 172.8 1.3 1.5e-50 171.8 1.3 1.5 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.29 EFA86730.1 - 1.6e-18 66.6 0.0 6.4e-10 39.0 0.0 2.8 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain GRAM PF02893.20 EFA86730.1 - 1e-13 51.1 0.7 3e-13 49.6 0.7 1.9 1 0 0 1 1 1 1 GRAM domain RasGEF_N PF00618.20 EFA86730.1 - 2.4e-13 50.2 0.9 2.4e-13 50.2 0.9 2.6 3 0 0 3 3 3 1 RasGEF N-terminal motif GAGA_bind PF06217.12 EFA86731.1 - 1.7 8.8 7.6 4 7.6 7.6 1.7 1 1 0 1 1 1 0 GAGA binding protein-like family SRP9-21 PF05486.12 EFA86731.1 - 2.9 8.3 11.5 4.2 7.8 5.7 2.7 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) Epimerase PF01370.21 EFA86732.1 - 1.3e-10 41.2 0.3 8.5e-10 38.5 0.3 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFA86732.1 - 4.6e-07 29.6 0.1 2.7e-06 27.1 0.1 1.9 1 1 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EFA86732.1 - 0.00015 21.3 1.4 0.053 12.9 0.1 3.5 2 2 2 4 4 4 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFA86732.1 - 0.0002 21.3 0.0 0.00033 20.6 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFA86732.1 - 0.0008 18.9 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase 3HCDH_N PF02737.18 EFA86732.1 - 0.0014 18.6 0.1 0.0034 17.3 0.1 1.7 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFA86732.1 - 0.0025 18.0 0.0 0.005 17.0 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Polysacc_synt_2 PF02719.15 EFA86732.1 - 0.006 15.8 0.0 0.0081 15.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFA86732.1 - 0.039 13.1 0.0 0.08 12.0 0.0 1.7 1 1 0 1 1 1 0 RmlD substrate binding domain DapB_N PF01113.20 EFA86732.1 - 0.047 13.8 0.1 0.11 12.6 0.1 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 EFA86732.1 - 0.098 12.6 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase F420_oxidored PF03807.17 EFA86732.1 - 0.11 13.1 0.0 0.34 11.5 0.0 1.9 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DXP_reductoisom PF02670.16 EFA86732.1 - 0.16 12.7 0.1 0.39 11.4 0.0 1.7 1 1 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase F5_F8_type_C PF00754.25 EFA86733.1 - 4.3e-13 49.5 0.7 5.7e-13 49.1 0.7 1.1 1 0 0 1 1 1 1 F5/8 type C domain Ras PF00071.22 EFA86734.1 - 1.1e-08 34.9 0.1 1.6e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFA86734.1 - 0.00022 21.4 0.0 0.00053 20.2 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RAP1 PF07218.11 EFA86734.1 - 0.014 13.7 8.2 0.015 13.7 8.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Secretin_N_2 PF07655.13 EFA86734.1 - 0.016 15.8 16.7 0.04 14.5 16.7 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain CCDC24 PF15669.5 EFA86734.1 - 3.4 7.5 9.4 3.7 7.4 8.5 1.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Miga PF10265.9 EFA86734.1 - 3.7 6.4 10.3 5.6 5.8 10.3 1.2 1 0 0 1 1 1 0 Mitoguardin P22_Tail-4 PF11650.8 EFA86735.1 - 0.0079 16.2 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 P22 tail accessory factor Coq4 PF05019.13 EFA86737.1 - 5.7e-86 287.4 0.0 7.2e-86 287.1 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 E1_DerP2_DerF2 PF02221.15 EFA86738.1 - 0.00072 20.0 0.0 0.00084 19.8 0.0 1.2 1 0 0 1 1 1 1 ML domain FSAP_sig_propep PF03032.15 EFA86738.1 - 0.076 13.1 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide Secretin_N_2 PF07655.13 EFA86739.1 - 0.0025 18.3 2.0 0.0059 17.1 2.0 1.6 1 0 0 1 1 1 1 Secretin N-terminal domain TPR_12 PF13424.6 EFA86739.1 - 0.0067 16.7 0.2 3.8 7.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86739.1 - 0.01 16.6 0.0 0.36 11.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA86739.1 - 0.027 14.5 2.4 2.6 8.3 1.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86739.1 - 0.043 14.0 1.3 13 6.3 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFA86739.1 - 0.073 13.7 0.1 0.36 11.5 0.2 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat DUF3792 PF12670.7 EFA86739.1 - 0.079 13.1 1.8 0.31 11.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) TPR_1 PF00515.28 EFA86739.1 - 0.09 12.6 0.4 13 5.8 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5350 PF17299.2 EFA86741.1 - 0.074 13.5 0.9 0.63 10.6 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5350) zf-H2C2_2 PF13465.6 EFA86741.1 - 9.2 6.9 21.9 0.074 13.5 6.4 3.9 3 0 0 3 3 3 0 Zinc-finger double domain BPL_LplA_LipB PF03099.19 EFA86742.1 - 4.9e-18 65.3 0.0 8.9e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EFA86742.1 - 0.0026 17.6 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain AMP-binding PF00501.28 EFA86744.1 - 5e-49 167.0 0.0 8e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFA86744.1 - 2.8e-48 164.3 0.0 6.4e-48 163.2 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EFA86744.1 - 1e-08 35.4 0.2 3.9e-08 33.5 0.2 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EFA86744.1 - 1e-08 34.9 0.5 1.3e-07 31.3 0.0 2.8 2 1 1 3 3 3 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFA86744.1 - 4.5e-05 22.6 0.1 0.00013 21.1 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family ZZ PF00569.17 EFA86744.1 - 0.029 14.2 7.1 0.061 13.1 7.1 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type AMP-binding_C PF13193.6 EFA86744.1 - 0.051 14.6 0.0 0.1 13.6 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain DUF2857 PF11198.8 EFA86744.1 - 0.08 12.7 0.0 0.3 10.9 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2857) DUF2499 PF10693.9 EFA86744.1 - 0.098 12.9 0.3 24 5.3 0.0 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2499) Phage_int_SAM_5 PF13102.6 EFA86744.1 - 0.1 13.0 1.2 0.34 11.3 0.1 2.5 2 0 0 2 2 2 0 Phage integrase SAM-like domain zf-UBR PF02207.20 EFA86744.1 - 0.39 10.9 5.5 0.83 9.9 5.5 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-C3HC4_3 PF13920.6 EFA86744.1 - 1.3 9.0 5.6 3.4 7.6 5.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EFA86744.1 - 2.5 8.1 7.8 8.9 6.3 7.8 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Mucin PF01456.17 EFA86745.1 - 0.02 14.9 8.3 0.023 14.7 8.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein NST1 PF13945.6 EFA86745.1 - 1.8 8.6 12.9 2.4 8.2 12.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator WD40 PF00400.32 EFA86746.1 - 1.3e-14 54.3 17.5 0.0016 19.2 0.2 7.6 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA86746.1 - 1.7e-09 37.8 1.8 0.033 14.5 0.1 4.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFA86746.1 - 0.0017 18.4 0.1 0.37 10.8 0.0 4.1 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region RhoGEF PF00621.20 EFA86747.1 - 2.4e-29 102.9 2.1 2.4e-29 102.9 2.1 3.0 2 1 1 3 3 3 1 RhoGEF domain SecA_PP_bind PF01043.20 EFA86747.1 - 0.1 13.2 0.0 0.44 11.2 0.0 2.1 1 0 0 1 1 1 0 SecA preprotein cross-linking domain EssA PF10661.9 EFA86747.1 - 0.34 10.7 14.4 0.028 14.3 4.4 3.2 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA MINDY_DUB PF04424.13 EFA86749.1 - 0.05 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 MINDY deubiquitinase Asp_Glu_race PF01177.22 EFA86751.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase DUF4094 PF13334.6 EFA86751.1 - 0.95 9.9 5.3 4.1 7.9 0.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) FMN_red PF03358.15 EFA86752.1 - 3.1e-25 88.7 0.0 4.7e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFA86752.1 - 2.2e-07 30.8 0.0 3.9e-07 30.0 0.0 1.4 2 0 0 2 2 2 1 Flavodoxin-like fold AKAP7_NLS PF10469.9 EFA86753.1 - 3.6e-34 118.5 0.5 1.7e-33 116.2 0.5 1.8 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain LigT_PEase PF02834.16 EFA86753.1 - 1.8e-06 28.1 0.2 0.016 15.4 0.0 2.6 2 1 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 EFA86753.1 - 2e-05 24.6 0.0 3.3e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily Lipl32 PF12103.8 EFA86753.1 - 0.0052 16.5 0.0 0.0079 15.9 0.0 1.2 1 0 0 1 1 1 1 Surface lipoprotein of Spirochaetales order TatC PF00902.18 EFA86753.1 - 0.079 12.8 0.1 0.2 11.4 0.1 1.6 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) DUF1110 PF06533.12 EFA86753.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) Sigma_reg_N PF13800.6 EFA86753.1 - 0.69 10.2 3.8 6.8 7.0 3.8 2.3 1 1 0 1 1 1 0 Sigma factor regulator N-terminal FMN_red PF03358.15 EFA86754.1 - 4.5e-28 97.9 0.0 6.6e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFA86754.1 - 8.6e-06 25.6 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold TPR_1 PF00515.28 EFA86755.1 - 4.3e-46 152.9 28.7 4.2e-08 32.7 0.1 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86755.1 - 8.7e-39 128.5 27.6 4.3e-06 26.4 0.1 8.6 8 0 0 8 8 8 8 Tetratricopeptide repeat STI1 PF17830.1 EFA86755.1 - 3.8e-36 122.8 6.5 4.9e-18 64.8 0.1 3.5 3 0 0 3 3 3 2 STI1 domain TPR_16 PF13432.6 EFA86755.1 - 1.4e-21 76.9 3.1 4.1e-05 24.1 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFA86755.1 - 3.4e-21 74.6 24.2 3.6e-06 26.6 0.1 7.7 6 1 1 7 7 7 6 TPR repeat TPR_8 PF13181.6 EFA86755.1 - 5e-20 70.0 24.8 0.0012 18.9 0.0 8.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86755.1 - 1.1e-17 64.1 19.7 1.1e-07 32.0 0.5 6.6 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86755.1 - 4.2e-15 55.2 3.5 0.73 10.8 0.0 7.0 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86755.1 - 7.6e-14 52.0 17.2 0.001 19.5 0.4 6.3 4 2 2 6 6 6 4 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA86755.1 - 3.6e-10 39.8 6.5 0.0049 16.9 0.0 5.0 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 EFA86755.1 - 1.1e-09 38.0 17.6 0.036 14.5 0.5 7.7 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFA86755.1 - 3e-07 30.1 17.1 0.84 9.6 0.1 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFA86755.1 - 4.2e-07 29.5 11.0 1.1 9.5 0.1 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat MIT PF04212.18 EFA86755.1 - 0.00017 21.6 15.3 0.17 12.0 1.4 6.3 6 0 0 6 6 6 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 EFA86755.1 - 0.00032 20.8 9.8 2.4 8.2 0.0 5.1 4 1 1 5 5 5 1 Domain of Unknown Function (DUF3856) TPR_9 PF13371.6 EFA86755.1 - 0.00067 19.8 0.4 2.7 8.2 0.0 4.8 4 2 3 7 7 7 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 EFA86755.1 - 0.0013 17.2 0.5 0.32 9.3 0.0 2.9 3 0 0 3 3 3 1 Spermatogenesis-associated, N-terminal ANAPC3 PF12895.7 EFA86755.1 - 0.0019 18.4 19.6 0.75 10.1 0.5 4.8 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 EFA86755.1 - 0.012 14.7 1.2 5 6.0 0.0 2.9 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 EFA86755.1 - 0.46 10.9 4.3 18 5.7 0.1 4.3 5 0 0 5 5 5 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 EFA86755.1 - 0.59 10.9 19.2 48 4.9 0.0 7.4 8 0 0 8 8 7 0 Tetratricopeptide repeat SMBP PF16785.5 EFA86755.1 - 1.8 8.8 4.7 28 5.0 0.5 2.9 2 0 0 2 2 2 0 Small metal-binding protein Alkyl_sulf_dimr PF14863.6 EFA86755.1 - 2.3 8.7 8.9 4.6 7.7 0.1 3.9 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation TPR_21 PF09976.9 EFA86755.1 - 9.4 5.9 10.1 1.5 8.5 0.6 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain PhoPQ_related PF10142.9 EFA86756.1 - 1.4e-95 320.1 1.4 2.7e-95 319.1 1.4 1.5 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein zf-4CXXC_R1 PF10497.9 EFA86756.1 - 6.6e-09 35.9 16.0 6.6e-09 35.9 16.0 2.2 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 PEHE PF15275.6 EFA86756.1 - 0.00044 20.9 6.5 0.00044 20.9 6.5 4.9 3 3 1 4 4 4 1 PEHE domain FYDLN_acid PF09538.10 EFA86756.1 - 0.014 16.1 3.2 0.014 16.1 3.2 5.5 4 2 1 5 5 5 0 Protein of unknown function (FYDLN_acid) Sas10_Utp3 PF04000.15 EFA86758.1 - 3.1e-13 50.2 1.2 3.9e-13 49.8 0.4 1.6 2 0 0 2 2 2 1 Sas10/Utp3/C1D family WD40 PF00400.32 EFA86759.1 - 5.9e-58 191.5 19.4 1e-10 42.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFA86759.1 - 6.6e-23 80.8 2.4 0.00025 21.3 0.0 5.9 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFA86759.1 - 6.4e-08 32.3 0.1 0.012 15.0 0.0 3.3 2 2 2 4 4 4 2 WD40-like domain Nup160 PF11715.8 EFA86759.1 - 1.2e-07 30.8 8.1 0.13 10.9 0.1 5.6 1 1 3 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFA86759.1 - 1.8e-07 30.4 0.3 0.26 10.2 0.0 4.7 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EFA86759.1 - 2.5e-05 23.0 0.1 1.1 7.8 0.0 3.3 2 1 1 3 3 3 3 Cytochrome D1 heme domain Frtz PF11768.8 EFA86759.1 - 0.00023 19.6 0.0 0.016 13.6 0.0 2.8 2 1 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_2 PF13360.6 EFA86759.1 - 0.00085 19.0 0.4 0.0094 15.6 0.1 2.5 1 1 1 2 2 2 1 PQQ-like domain Hira PF07569.11 EFA86759.1 - 0.016 14.9 3.1 9.5 5.9 0.1 4.2 3 1 1 4 4 4 0 TUP1-like enhancer of split PD40 PF07676.12 EFA86759.1 - 0.045 13.7 2.1 2.9 7.9 0.1 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat SBD PF17882.1 EFA86759.1 - 0.048 13.5 0.9 0.61 9.9 0.1 2.7 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain Gaa1 PF04114.14 EFA86760.1 - 3.9e-79 267.0 10.0 7.3e-79 266.1 10.0 1.4 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component DUF4834 PF16118.5 EFA86760.1 - 2.5 9.1 12.3 15 6.6 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) SSP160 PF06933.11 EFA86760.1 - 4 5.5 28.3 1.6 6.8 10.3 2.3 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 DUF4834 PF16118.5 EFA86761.1 - 0.0022 18.9 0.2 0.0034 18.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) PPR_2 PF13041.6 EFA86762.1 - 0.00021 21.4 2.9 3 8.1 0.1 5.5 7 0 0 7 7 7 2 PPR repeat family Methyltransf_12 PF08242.12 EFA86762.1 - 0.4 11.4 4.9 0.56 11.0 1.6 3.0 2 0 0 2 2 2 0 Methyltransferase domain PIP5K PF01504.18 EFA86763.1 - 3.4e-65 220.0 12.3 6.7e-65 219.0 12.3 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Frizzled PF01534.17 EFA86763.1 - 0.00028 20.1 2.9 0.0031 16.6 0.5 2.2 2 0 0 2 2 2 2 Frizzled/Smoothened family membrane region GPR_Gpa2_C PF11970.8 EFA86763.1 - 0.0077 16.3 2.8 0.044 13.9 0.1 3.0 2 1 1 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term PI3Ka PF00613.20 EFA86765.1 - 5.7e-53 179.1 3.0 1.3e-52 177.9 3.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFA86765.1 - 2e-46 158.9 0.1 2.9e-45 155.1 0.1 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 EFA86765.1 - 7.7e-07 29.2 0.3 2.5e-06 27.6 0.1 2.0 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 EFA86765.1 - 0.0045 16.4 0.0 0.0089 15.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Ank_2 PF12796.7 EFA86767.1 - 1.6e-36 124.8 16.1 6.5e-11 42.7 0.2 7.8 2 2 8 10 10 10 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFA86767.1 - 5.1e-27 93.9 14.0 3e-05 24.5 0.3 11.7 4 4 8 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86767.1 - 7.4e-21 72.0 18.8 1 10.1 0.0 15.8 15 2 2 17 17 17 5 Ankyrin repeat Ank_5 PF13857.6 EFA86767.1 - 1.6e-18 66.5 13.6 0.027 14.8 0.1 11.6 5 3 7 12 12 12 4 Ankyrin repeats (many copies) DUF249 PF03158.13 EFA86767.1 - 3.4e-08 33.4 7.5 0.0089 15.8 0.0 6.7 5 2 2 7 7 7 2 Multigene family 530 protein DUF3447 PF11929.8 EFA86767.1 - 9.5e-05 22.3 26.8 0.0004 20.3 0.0 8.2 6 2 2 8 8 8 2 Domain of unknown function (DUF3447) Ank PF00023.30 EFA86767.1 - 0.0098 16.3 11.7 81 3.9 0.2 9.1 8 2 2 10 10 10 0 Ankyrin repeat FBD PF08387.10 EFA86767.1 - 0.12 12.3 0.3 59 3.7 0.0 4.2 4 0 0 4 4 4 0 FBD LRR_6 PF13516.6 EFA86767.1 - 0.79 9.9 5.1 19 5.6 0.4 3.5 2 0 0 2 2 2 0 Leucine Rich repeat DNA_PPF PF02916.15 EFA86767.1 - 6.8 7.1 7.6 0.71 10.3 1.0 2.6 2 1 1 3 3 3 0 DNA polymerase processivity factor Aminotran_1_2 PF00155.21 EFA86768.1 - 1.6e-09 37.4 0.0 8e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_1_2 PF00155.21 EFA86769.1 - 8.9e-16 58.0 0.0 1.1e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EFA86769.1 - 8.7e-07 28.1 0.0 1e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Alpha_L_fucos PF01120.17 EFA86770.1 - 2.3e-114 382.5 7.9 3.4e-114 381.9 7.9 1.2 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 EFA86770.1 - 3.5e-16 59.5 0.1 8.8e-16 58.3 0.1 1.7 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain UDPGP PF01704.18 EFA86771.1 - 2.1e-157 524.0 5.7 2.5e-157 523.8 5.7 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Aminotran_5 PF00266.19 EFA86772.1 - 9.2e-39 133.4 0.0 1.4e-38 132.8 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFA86772.1 - 0.00011 20.8 0.0 0.00015 20.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PALP PF00291.25 EFA86772.1 - 0.00032 20.2 0.0 0.00091 18.7 0.0 1.7 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFA86772.1 - 0.035 13.4 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EFA86772.1 - 0.31 9.7 2.0 0.81 8.3 0.1 2.5 4 0 0 4 4 4 0 Pyridoxal-dependent decarboxylase conserved domain Acyl_transf_3 PF01757.22 EFA86774.1 - 3e-25 89.0 50.8 3e-25 89.0 50.8 1.6 2 0 0 2 2 2 1 Acyltransferase family Sedlin_N PF04628.13 EFA86777.1 - 6.3e-44 149.3 2.6 6.3e-44 149.3 2.6 1.9 3 0 0 3 3 3 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EFA86777.1 - 1.7e-07 31.3 0.9 6.5e-07 29.4 0.4 2.1 1 1 1 2 2 2 1 Sybindin-like family DUF508 PF04370.12 EFA86777.1 - 0.13 12.0 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF508) LMBR1 PF04791.16 EFA86778.1 - 5.3e-20 71.8 20.0 1.2e-17 64.0 3.2 2.5 1 1 1 2 2 2 2 LMBR1-like membrane protein DUF5050 PF16472.5 EFA86779.1 - 0.00074 18.8 0.6 0.0099 15.2 0.6 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF5050) Laminin_EGF PF00053.24 EFA86779.1 - 0.0095 16.1 5.6 0.0095 16.1 5.6 3.6 2 1 1 3 3 3 1 Laminin EGF domain G8 PF10162.9 EFA86780.1 - 5.3e-25 87.9 0.4 2.2e-24 85.9 0.1 2.2 2 0 0 2 2 2 1 G8 domain Beta_helix PF13229.6 EFA86780.1 - 0.005 16.7 6.8 0.005 16.7 6.8 3.4 2 1 1 3 3 3 1 Right handed beta helix region Amnionless PF14828.6 EFA86780.1 - 0.015 14.1 0.3 0.044 12.6 0.0 1.7 2 0 0 2 2 2 0 Amnionless RhoGAP PF00620.27 EFA86781.1 - 2.4e-24 85.9 1.5 5.7e-24 84.7 0.1 2.4 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EFA86781.1 - 3.8e-14 52.7 0.6 2.2e-13 50.3 0.2 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF2935 PF11155.8 EFA86781.1 - 0.028 14.8 0.7 0.13 12.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DUF2258 PF10015.9 EFA86781.1 - 0.13 12.4 0.5 3.4 7.9 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) SVWC PF15430.6 EFA86782.1 - 2.1e-05 24.7 5.0 4.5e-05 23.6 5.0 1.5 1 0 0 1 1 1 1 Single domain von Willebrand factor type C dCMP_cyt_deam_1 PF00383.23 EFA86783.1 - 8.1e-15 54.5 1.0 1.5e-14 53.7 1.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFA86783.1 - 5.1e-09 36.0 1.5 9.6e-09 35.1 1.5 1.5 1 1 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EFA86783.1 - 0.058 13.5 3.5 2.3 8.3 0.2 2.2 1 1 1 2 2 2 0 Bd3614-like deaminase DUF2039 PF10217.9 EFA86783.1 - 0.52 10.7 4.9 0.63 10.4 1.7 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) FACT-Spt16_Nlob PF14826.6 EFA86784.1 - 1.3e-50 171.3 1.6 3e-50 170.1 1.6 1.7 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.11 EFA86784.1 - 3.2e-49 167.0 0.6 3.2e-49 167.0 0.6 4.0 4 0 0 4 4 4 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 EFA86784.1 - 1.7e-31 109.6 0.0 3e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EFA86784.1 - 1e-16 61.1 2.9 1.9e-16 60.2 0.1 2.8 3 0 0 3 3 3 1 Histone chaperone Rttp106-like Skp1 PF01466.19 EFA86784.1 - 0.028 14.6 0.2 3.9 7.7 0.0 3.2 2 0 0 2 2 2 0 Skp1 family, dimerisation domain G6PD_C PF02781.16 EFA86784.1 - 0.68 9.1 5.0 2.5 7.2 0.9 2.4 2 0 0 2 2 2 0 Glucose-6-phosphate dehydrogenase, C-terminal domain LSM PF01423.22 EFA86785.1 - 1.8e-23 82.0 1.0 2.1e-23 81.8 1.0 1.0 1 0 0 1 1 1 1 LSM domain FNIP PF05725.12 EFA86786.1 - 6e-31 106.3 16.9 1.8e-12 47.2 0.0 5.6 6 2 0 7 7 7 3 FNIP Repeat F-box_5 PF18511.1 EFA86786.1 - 0.043 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box Guanylate_cyc PF00211.20 EFA86787.1 - 9.9e-51 172.0 0.1 1.7e-50 171.2 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain MHYT PF03707.16 EFA86787.1 - 2.9e-32 110.6 23.2 2.6e-12 46.7 1.9 4.4 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat SelP_N PF04592.14 EFA86787.1 - 0.94 8.8 10.5 1.7 8.0 10.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF373 PF04123.13 EFA86787.1 - 1.8 7.9 5.0 3.8 6.8 5.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Macoilin PF09726.9 EFA86787.1 - 2.3 6.6 12.8 4.2 5.8 12.8 1.3 1 0 0 1 1 1 0 Macoilin family Nop25 PF09805.9 EFA86788.1 - 0.014 15.9 6.0 0.014 15.9 6.0 2.5 2 1 1 3 3 3 0 Nucleolar protein 12 (25kDa) Eapp_C PF10238.9 EFA86788.1 - 0.25 11.4 10.0 1.3 9.1 3.5 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF4969 PF16339.5 EFA86788.1 - 0.69 10.3 5.1 1.7 9.0 2.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4969) Secretin_N_2 PF07655.13 EFA86788.1 - 1.2 9.8 18.6 11 6.6 12.3 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain CagY_I PF14585.6 EFA86789.1 - 0.00049 20.1 0.6 0.00049 20.1 0.6 2.4 2 0 0 2 2 2 1 CagY type 1 repeat Pox_A_type_inc PF04508.12 EFA86789.1 - 0.011 15.6 13.7 2.9 7.9 0.3 5.1 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat Lipoprotein_7 PF01540.16 EFA86789.1 - 0.05 12.9 20.8 0.067 12.5 20.8 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein Imm58 PF15581.6 EFA86789.1 - 0.21 11.7 1.3 1.4 9.0 0.1 2.1 1 1 0 2 2 2 0 Immunity protein 58 NADH_4Fe-4S PF10589.9 EFA86789.1 - 0.32 11.1 1.8 2.5 8.2 0.3 2.5 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GA PF01468.17 EFA86789.1 - 0.42 10.9 0.2 0.42 10.9 0.2 3.8 3 1 1 4 4 4 0 GA module DUF489 PF04356.12 EFA86789.1 - 0.57 10.2 13.0 0.83 9.6 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF489) PRKG1_interact PF15898.5 EFA86789.1 - 0.68 10.9 30.4 0.59 11.1 7.5 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Phage_GP20 PF06810.11 EFA86789.1 - 0.77 9.6 29.2 0.14 11.9 11.1 3.1 1 1 2 3 3 3 0 Phage minor structural protein GP20 TPR_MLP1_2 PF07926.12 EFA86789.1 - 1.3 9.1 33.5 0.5 10.4 12.5 3.7 1 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein ApoO PF09769.9 EFA86789.1 - 1.3 9.0 6.0 1.1 9.2 0.7 2.5 2 1 0 2 2 2 0 Apolipoprotein O Hydrolase_6 PF13344.6 EFA86789.1 - 1.8 8.7 5.2 0.36 11.0 0.4 2.2 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Sec3_C_2 PF15278.6 EFA86789.1 - 3.3 8.1 16.7 1.1 9.7 2.9 3.3 2 2 1 3 3 3 0 Sec3 exocyst complex subunit FlaC_arch PF05377.11 EFA86789.1 - 5.8 7.4 22.6 3.2 8.2 0.1 4.6 3 2 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF2315 PF10231.9 EFA86789.1 - 7.9 6.6 15.5 16 5.6 1.9 2.8 2 1 0 2 2 2 0 Apoptogenic protein 1 VIT PF08487.10 EFA86791.1 - 1.8e-32 111.9 1.4 5.3e-32 110.3 1.4 1.9 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EFA86791.1 - 2.3e-27 95.8 0.0 8.3e-27 94.0 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFA86791.1 - 2e-13 51.0 0.0 5.1e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFA86791.1 - 6.4e-10 39.6 0.0 1.7e-09 38.3 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EFA86791.1 - 0.00014 21.7 0.2 0.00031 20.6 0.2 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain phiKZ_IP PF12699.7 EFA86791.1 - 0.0025 17.0 0.3 0.0052 16.0 0.0 1.6 2 0 0 2 2 2 1 phiKZ-like phage internal head proteins GATA-N PF05349.12 EFA86791.1 - 0.064 13.6 0.2 0.57 10.5 0.1 2.2 2 0 0 2 2 2 0 GATA-type transcription activator, N-terminal BTB PF00651.31 EFA86792.1 - 1.4e-25 89.6 1.7 2.5e-25 88.9 1.7 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 EFA86792.1 - 1.4e-17 63.5 6.2 8.9e-09 35.2 0.3 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFA86792.1 - 2.2e-17 62.7 4.5 1.1e-07 31.9 0.3 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFA86792.1 - 9e-17 60.9 7.6 1e-07 32.0 0.7 4.6 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFA86792.1 - 3e-13 49.1 2.5 3.5e-07 29.7 0.3 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EFA86792.1 - 2.4e-11 43.3 5.6 5.6e-06 26.2 0.3 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EFA86792.1 - 1.3e-08 34.5 5.5 0.0023 17.9 1.0 3.5 2 1 0 2 2 2 2 Kelch motif BTB_3 PF16017.5 EFA86792.1 - 0.013 15.6 0.1 0.023 14.8 0.1 1.4 1 0 0 1 1 1 0 BTB/POZ domain DKCLD PF08068.12 EFA86793.1 - 3.8e-34 116.5 0.4 2.4e-32 110.8 0.5 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EFA86793.1 - 4e-23 81.3 0.2 7.3e-23 80.5 0.2 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EFA86793.1 - 4.2e-21 74.7 0.9 8.9e-21 73.7 0.9 1.6 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.18 EFA86793.1 - 1.1e-18 68.0 0.2 1.1e-18 68.0 0.2 4.3 2 2 1 3 3 3 1 TruB family pseudouridylate synthase (N terminal domain) UPF0113 PF03657.13 EFA86793.1 - 0.0039 17.4 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 UPF0113 PUA domain OrfB_Zn_ribbon PF07282.11 EFA86795.1 - 0.029 14.3 3.8 2.2 8.3 0.7 3.4 3 0 0 3 3 3 0 Putative transposase DNA-binding domain FAM176 PF14851.6 EFA86795.1 - 0.28 10.8 14.6 0.48 10.1 6.8 2.7 2 0 0 2 2 2 0 FAM176 family Nucleoside_tran PF01733.18 EFA86795.1 - 2.6 7.3 5.1 4 6.7 0.2 2.3 2 0 0 2 2 2 0 Nucleoside transporter PBP1_TM PF14812.6 EFA86795.1 - 6.8 7.1 24.1 0.19 12.1 3.3 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AF-4 PF05110.13 EFA86797.1 - 0.00015 20.0 22.4 0.00017 19.9 22.4 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein DUF3797 PF12677.7 EFA86797.1 - 0.05 13.5 1.0 0.1 12.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) HigB_toxin PF09907.9 EFA86797.1 - 0.062 13.5 0.2 0.12 12.6 0.2 1.5 1 0 0 1 1 1 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system GvpL_GvpF PF06386.11 EFA86797.1 - 0.21 11.5 5.3 0.35 10.8 5.3 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Noggin PF05806.12 EFA86797.1 - 2.1 8.2 4.9 2.9 7.8 4.4 1.4 1 1 0 1 1 1 0 Noggin Macoilin PF09726.9 EFA86797.1 - 4.7 5.7 24.1 6.8 5.1 24.1 1.3 1 0 0 1 1 1 0 Macoilin family UCH PF00443.29 EFA86799.1 - 3e-27 95.7 26.7 1.1e-26 93.9 26.7 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EFA86799.1 - 0.047 13.1 13.0 0.086 12.3 3.2 3.4 2 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Mucin PF01456.17 EFA86799.1 - 1.7 8.7 13.6 3.2 7.7 13.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein BTB_2 PF02214.22 EFA86800.1 - 8.6e-18 64.5 0.2 3.5e-17 62.5 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain BTB PF00651.31 EFA86800.1 - 7.6e-05 22.9 0.0 0.0002 21.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Aminotran_1_2 PF00155.21 EFA86801.1 - 3.1e-55 187.8 0.0 3.6e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFA86801.1 - 0.082 11.4 0.0 0.2 10.2 0.0 1.6 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFA86801.1 - 0.09 11.7 0.0 0.29 10.1 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V GDC-P PF02347.16 EFA86802.1 - 2.4e-187 623.1 4.0 1.9e-179 597.1 0.2 2.9 3 1 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 EFA86802.1 - 0.00078 18.5 0.2 0.022 13.7 0.0 2.5 2 1 0 2 2 2 1 Aminotransferase class-V MerR_2 PF13591.6 EFA86802.1 - 0.16 11.8 0.2 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 MerR HTH family regulatory protein 5_nucleotid PF05761.14 EFA86803.1 - 2e-49 168.7 1.2 2.6e-46 158.5 0.0 2.8 1 1 2 3 3 3 2 5' nucleotidase family Hydrolase PF00702.26 EFA86803.1 - 0.0024 18.2 0.0 0.007 16.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Rtf2 PF04641.12 EFA86804.1 - 0.0079 15.6 6.9 0.016 14.6 6.9 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger Retrotrans_gag PF03732.17 EFA86804.1 - 0.075 13.3 2.9 0.21 11.9 1.2 2.2 2 0 0 2 2 2 0 Retrotransposon gag protein DDE_Tnp_1_assoc PF13808.6 EFA86804.1 - 0.09 12.8 0.1 6 7.0 0.0 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-associated VitD-bind_III PF09164.10 EFA86804.1 - 0.39 10.7 1.6 4.7 7.3 0.0 2.8 3 0 0 3 3 3 0 Vitamin D binding protein, domain III Zip PF02535.22 EFA86804.1 - 0.44 9.7 1.1 0.51 9.5 1.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Tli4_N PF18443.1 EFA86804.1 - 1.5 9.2 6.9 1.2 9.5 3.0 2.3 1 1 1 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain Peptidase_S49_N PF08496.10 EFA86804.1 - 1.8 8.6 9.0 1.6 8.8 6.7 1.9 1 1 1 2 2 2 0 Peptidase family S49 N-terminal Rotamase PF00639.21 EFA86804.1 - 2.6 9.1 10.6 27 5.8 0.1 2.6 2 1 1 3 3 3 0 PPIC-type PPIASE domain YgaB PF14182.6 EFA86804.1 - 4.9 7.6 10.9 0.69 10.3 6.0 2.0 2 1 0 2 2 2 0 YgaB-like protein Kelch_6 PF13964.6 EFA86805.1 - 3.9e-11 42.8 1.6 1.6e-10 40.9 0.1 2.6 2 1 1 3 3 3 1 Kelch motif G-patch PF01585.23 EFA86806.1 - 1.4e-09 37.7 0.5 2.4e-09 36.9 0.5 1.4 1 0 0 1 1 1 1 G-patch domain NmrA PF05368.13 EFA86807.1 - 9.7e-28 97.3 1.0 2.9e-27 95.7 0.7 1.9 2 1 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EFA86807.1 - 4.5e-08 33.2 0.1 7.7e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Ig_mannosidase PF17753.1 EFA86808.1 - 8.7e-16 57.5 0.1 2.1e-15 56.3 0.1 1.7 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 EFA86808.1 - 8.5e-11 42.3 0.0 2.2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_N PF02837.18 EFA86808.1 - 7.4e-06 26.0 2.2 2.7e-05 24.2 0.1 2.7 3 0 0 3 3 3 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EFA86808.1 - 0.018 15.7 3.1 0.029 15.0 0.1 2.7 2 1 0 2 2 2 0 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 EFA86808.1 - 0.052 12.7 0.2 0.27 10.3 0.2 2.0 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Sushi_2 PF09014.10 EFA86808.1 - 0.081 12.8 0.3 7.3 6.6 0.1 2.7 2 0 0 2 2 2 0 Beta-2-glycoprotein-1 fifth domain DUF1835 PF08874.10 EFA86808.1 - 0.13 12.4 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) Clat_adaptor_s PF01217.20 EFA86809.1 - 1.6e-48 164.2 7.6 1.6e-48 164.2 7.6 2.6 3 1 0 3 3 2 1 Clathrin adaptor complex small chain MID_MedPIWI PF18296.1 EFA86809.1 - 0.15 11.8 14.7 0.1 12.4 12.4 1.7 2 0 0 2 2 2 0 MID domain of medPIWI CPSF100_C PF13299.6 EFA86809.1 - 0.36 11.0 8.2 0.57 10.4 8.2 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TFIIA PF03153.13 EFA86809.1 - 0.39 10.7 28.6 0.6 10.1 28.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Band_3_cyto PF07565.13 EFA86809.1 - 0.97 9.2 9.6 1.6 8.5 9.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spt20 PF12090.8 EFA86809.1 - 1.1 8.8 33.5 1.9 8.0 33.5 1.4 1 0 0 1 1 1 0 Spt20 family RR_TM4-6 PF06459.12 EFA86809.1 - 1.5 8.6 12.4 2.3 8.0 12.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5580 PF17743.1 EFA86809.1 - 2.1 6.8 15.7 3.1 6.2 15.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EIIBC-GUT_N PF03612.14 EFA86809.1 - 2.7 7.7 8.5 3.4 7.4 6.9 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 EFA86809.1 - 2.8 6.6 16.2 4.4 6.0 16.2 1.2 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 EFA86809.1 - 3 7.9 12.2 5.1 7.2 12.2 1.3 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 EFA86809.1 - 4.8 7.2 7.9 7.9 6.5 7.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Arm PF00514.23 EFA86811.1 - 2.5e-14 52.7 0.6 0.0013 18.7 0.0 5.3 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HECT PF00632.25 EFA86812.1 - 6.1e-84 282.1 0.8 1.1e-83 281.3 0.8 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Arm PF00514.23 EFA86812.1 - 0.047 13.7 0.2 8.9 6.5 0.0 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Pkinase PF00069.25 EFA86813.1 - 2.5e-34 118.8 0.8 1.5e-22 80.2 0.1 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFA86813.1 - 4e-14 52.5 0.4 2.9e-10 39.9 0.2 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Macoilin PF09726.9 EFA86813.1 - 0.32 9.5 32.3 0.33 9.4 23.9 2.1 2 0 0 2 2 2 0 Macoilin family Roughex PF06020.11 EFA86813.1 - 0.38 9.8 6.4 0.63 9.1 6.4 1.4 1 0 0 1 1 1 0 Drosophila roughex protein SOG2 PF10428.9 EFA86813.1 - 0.78 8.9 30.6 0.82 8.8 22.4 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein ATP-synt_E PF05680.12 EFA86813.1 - 1.4 9.3 5.0 4.3 7.8 1.0 2.7 2 1 0 2 2 2 0 ATP synthase E chain Ndc1_Nup PF09531.10 EFA86813.1 - 3.8 6.1 17.6 2.4 6.8 14.6 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SRP-alpha_N PF04086.13 EFA86813.1 - 4.4 7.2 21.5 1 9.3 14.6 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Pkinase_fungal PF17667.1 EFA86813.1 - 7.6 5.2 18.2 0.015 14.1 0.6 2.6 1 1 1 2 2 2 0 Fungal protein kinase SpoIIE PF07228.12 EFA86814.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Peroxin-3 PF04882.12 EFA86815.1 - 1.5e-22 80.3 6.8 2.1e-18 66.6 2.6 2.7 1 1 1 2 2 2 2 Peroxin-3 TFIIS_C PF01096.18 EFA86815.1 - 0.23 11.3 0.5 0.57 10.1 0.2 1.9 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Pex14_N PF04695.13 EFA86816.1 - 0.63 10.7 5.9 1.3 9.7 5.9 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Macro PF01661.21 EFA86817.1 - 2.8e-28 98.3 0.5 7.8e-28 96.9 0.5 1.8 1 0 0 1 1 1 1 Macro domain PARP PF00644.20 EFA86817.1 - 5.9e-17 61.9 1.6 1.9e-16 60.3 0.4 2.6 3 1 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EFA86817.1 - 1.1e-12 48.3 1.9 1.3e-11 44.9 0.3 3.7 2 0 0 2 2 2 1 WWE domain SLS PF14611.6 EFA86817.1 - 0.00046 20.1 2.3 0.0029 17.5 0.1 3.1 2 1 0 3 3 3 1 Mitochondrial inner-membrane-bound regulator FNIP PF05725.12 EFA86818.1 - 7.9e-23 80.4 25.2 4.1e-06 26.8 0.2 7.9 3 2 5 9 9 9 9 FNIP Repeat Maelstrom PF13017.6 EFA86818.1 - 0.06 13.0 0.2 0.1 12.2 0.2 1.4 1 1 0 1 1 1 0 piRNA pathway germ-plasm component FNIP PF05725.12 EFA86820.1 - 4.1e-32 110.1 15.7 1.9e-11 44.0 0.1 5.6 3 1 1 5 5 5 4 FNIP Repeat Metallophos PF00149.28 EFA86820.1 - 1.2e-13 52.1 1.9 4e-13 50.3 1.9 2.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4667 PF15700.5 EFA86820.1 - 0.00011 22.4 1.0 0.00025 21.2 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4667) DMT_6 PF04342.12 EFA86820.1 - 0.014 15.6 0.6 0.05 13.8 0.0 2.3 2 0 0 2 2 2 0 Putative member of DMT superfamily (DUF486) DUF1565 PF07602.11 EFA86820.1 - 0.03 13.7 0.0 0.03 13.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1565) DUF508 PF04370.12 EFA86820.1 - 0.5 10.1 10.5 1.9 8.2 10.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Chorion_2 PF03964.15 EFA86820.1 - 0.58 11.0 14.6 0.029 15.2 8.0 2.2 2 0 0 2 2 2 0 Chorion family 2 RNF220 PF15926.5 EFA86820.1 - 0.66 9.6 2.2 1.3 8.6 2.2 1.4 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 DUF3899 PF13038.6 EFA86820.1 - 3.5 8.2 7.2 0.16 12.5 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF1635 PF07795.11 EFA86820.1 - 3.8 7.3 4.9 7.5 6.3 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) zf-CCHC PF00098.23 EFA86821.1 - 2.8e-11 42.9 23.0 4.7e-05 23.3 2.7 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 EFA86821.1 - 0.028 14.4 0.7 0.028 14.4 0.7 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 EFA86821.1 - 0.047 13.4 17.8 0.37 10.5 1.3 3.4 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 EFA86821.1 - 0.84 9.5 21.6 1.6 8.6 2.6 3.4 3 0 0 3 3 3 0 Zinc knuckle SRP68 PF16969.5 EFA86822.1 - 3.3e-114 382.9 28.0 3.8e-114 382.7 28.0 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 DbpA PF03880.15 EFA86822.1 - 0.065 13.2 0.8 0.16 12.0 0.2 2.0 2 0 0 2 2 2 0 DbpA RNA binding domain SATase_N PF06426.14 EFA86822.1 - 0.34 11.3 3.9 6.1 7.3 0.1 3.3 3 0 0 3 3 3 0 Serine acetyltransferase, N-terminal DUF2939 PF11159.8 EFA86822.1 - 1.9 8.9 5.3 2.9 8.4 0.7 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) EnY2 PF10163.9 EFA86824.1 - 0.0029 17.9 1.5 0.0085 16.4 1.5 1.9 1 0 0 1 1 1 1 Transcription factor e(y)2 C2 PF00168.30 EFA86825.1 - 1.7e-17 63.6 0.2 4.2e-17 62.3 0.2 1.7 1 0 0 1 1 1 1 C2 domain Arrestin_C PF02752.22 EFA86825.1 - 1.2e-14 55.0 4.3 1.1e-13 51.8 0.7 2.6 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFA86825.1 - 9.7e-10 38.7 0.5 5.5e-08 33.0 0.2 2.8 2 2 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain SAM_1 PF00536.30 EFA86825.1 - 3.4e-08 33.8 0.0 6.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFA86825.1 - 6.2e-06 26.2 0.2 0.00024 21.2 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Rgp1 PF08737.10 EFA86825.1 - 0.099 11.8 0.8 9.4 5.3 0.0 2.5 3 0 0 3 3 3 0 Rgp1 Coiled PF05710.12 EFA86826.1 - 4e-20 72.4 14.5 4.7e-20 72.2 14.5 1.1 1 0 0 1 1 1 1 Coiled coil Coiled PF05710.12 EFA86827.1 - 3.1e-20 72.8 18.9 3.7e-20 72.5 18.9 1.1 1 0 0 1 1 1 1 Coiled coil His_Phos_1 PF00300.22 EFA86828.1 - 3e-13 49.9 0.0 1.2e-11 44.7 0.0 2.2 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) PEMT PF04191.13 EFA86829.1 - 3.4e-30 104.6 1.8 3.4e-30 104.6 1.8 2.0 2 0 0 2 2 2 1 Phospholipid methyltransferase Steroid_dh PF02544.16 EFA86829.1 - 0.00064 19.7 1.7 0.00088 19.3 0.8 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Coiled PF05710.12 EFA86830.1 - 3.3e-20 72.7 18.9 3.9e-20 72.5 18.9 1.1 1 0 0 1 1 1 1 Coiled coil Coiled PF05710.12 EFA86831.1 - 1.2e-19 70.9 18.9 1.4e-19 70.7 18.9 1.1 1 0 0 1 1 1 1 Coiled coil TPR_2 PF07719.17 EFA86832.1 - 4.7e-07 29.4 2.7 1.5 9.2 0.0 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86832.1 - 1.2e-05 24.9 8.3 0.57 10.1 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86832.1 - 6.1e-05 23.2 1.2 2.4 8.5 0.2 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86832.1 - 0.0001 22.7 5.3 2.9 8.5 0.0 6.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86832.1 - 0.00037 21.1 0.0 6.7 7.8 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFA86832.1 - 0.00051 20.6 0.0 4.8 7.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFA86832.1 - 0.0011 18.8 0.1 2.8 8.0 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFA86832.1 - 0.0057 17.2 0.2 89 4.1 0.0 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA86832.1 - 0.0062 16.7 7.1 1.1 9.5 1.1 4.8 3 2 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EFA86832.1 - 0.01 15.9 0.9 18 5.5 0.0 4.4 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat Casc1_N PF15927.5 EFA86832.1 - 0.23 11.2 2.6 3.1 7.4 0.0 2.9 3 0 0 3 3 3 0 Cancer susceptibility candidate 1 N-terminus Stap_Strp_toxin PF01123.20 EFA86832.1 - 0.24 12.3 4.8 0.18 12.7 1.2 2.6 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain TPR_8 PF13181.6 EFA86832.1 - 0.34 11.2 2.5 22 5.6 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank_2 PF12796.7 EFA86834.1 - 4.7e-21 75.2 4.2 2e-06 28.3 0.1 4.3 1 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFA86834.1 - 2e-19 69.4 5.9 0.037 14.4 0.0 8.7 2 2 7 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFA86834.1 - 2.6e-18 66.1 5.3 0.0086 16.6 0.0 6.0 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFA86834.1 - 3.6e-12 45.3 0.5 14 6.7 0.0 9.2 9 1 1 10 10 10 1 Ankyrin repeat DEDD_Tnp_IS110 PF01548.17 EFA86834.1 - 0.026 14.4 0.0 0.18 11.6 0.0 2.2 2 0 0 2 2 2 0 Transposase Ank PF00023.30 EFA86834.1 - 0.032 14.7 0.1 40 4.9 0.0 4.9 3 1 1 4 4 4 0 Ankyrin repeat DUF3447 PF11929.8 EFA86834.1 - 0.2 11.6 3.0 8.5 6.4 0.1 3.6 2 2 2 4 4 4 0 Domain of unknown function (DUF3447) MukF_M PF17192.4 EFA86835.1 - 0.16 11.7 2.3 0.36 10.6 1.3 2.0 2 0 0 2 2 2 0 MukF middle domain Dna2 PF08696.11 EFA86835.1 - 0.21 11.4 5.8 0.17 11.6 0.2 2.8 3 0 0 3 3 3 0 DNA replication factor Dna2 EntA_Immun PF08951.10 EFA86835.1 - 1.9 8.9 11.4 0.2 12.0 1.0 3.8 3 0 0 3 3 3 0 Enterocin A Immunity TPR_14 PF13428.6 EFA86836.1 - 6.7e-06 26.5 3.1 3.2 8.8 0.1 5.8 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86836.1 - 4.2e-05 23.4 2.9 5 7.5 0.3 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86836.1 - 8.9e-05 22.1 7.0 0.29 11.0 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86836.1 - 0.00072 19.8 3.8 1.1 9.6 0.1 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86836.1 - 0.0015 19.0 2.5 0.12 12.9 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA86836.1 - 0.11 12.8 4.2 2.1 8.6 0.1 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFA86836.1 - 0.6 10.3 3.0 9.7 6.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86836.1 - 1.1 9.6 4.7 6.9 7.2 0.8 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFA86836.1 - 1.4 9.1 4.2 3.3 7.9 0.0 2.9 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Apis_Csd PF11671.8 EFA86836.1 - 4.8 7.2 12.0 21 5.1 8.4 2.2 2 0 0 2 2 2 0 Complementary sex determiner protein TPR_19 PF14559.6 EFA86837.1 - 2.1e-10 41.0 1.0 3.3e-05 24.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFA86837.1 - 1.7e-06 27.6 9.7 0.18 11.7 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86837.1 - 4.8e-06 26.3 6.8 7.2 7.0 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFA86837.1 - 4e-05 24.1 0.1 9.5 7.3 0.0 6.4 5 3 2 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86837.1 - 6.5e-05 23.1 5.5 0.58 10.5 0.9 5.8 6 1 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFA86837.1 - 0.0052 17.0 6.2 0.25 11.6 0.1 3.9 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EFA86837.1 - 0.023 14.8 0.8 4.1 7.5 0.0 4.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat MukF_M PF17192.4 EFA86837.1 - 0.047 13.4 1.1 0.21 11.3 1.1 2.1 1 0 0 1 1 1 0 MukF middle domain TPR_10 PF13374.6 EFA86837.1 - 0.049 13.5 0.4 98 3.0 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFA86837.1 - 1.6 8.9 3.8 87 3.5 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat WAP PF00095.21 EFA86838.1 - 8.8e-08 32.4 10.4 1e-07 32.2 10.4 1.1 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF1139 PF06599.11 EFA86839.1 - 0.028 13.8 0.2 0.096 12.1 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1139) Ribosomal_L4 PF00573.22 EFA86839.1 - 0.1 12.3 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family TPR_17 PF13431.6 EFA86839.1 - 0.13 12.7 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Uma2 PF05685.12 EFA86840.1 - 0.012 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative restriction endonuclease TPR_1 PF00515.28 EFA86840.1 - 0.065 13.1 1.3 0.57 10.1 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 EFA86840.1 - 0.18 11.5 6.0 0.12 12.0 0.4 3.1 4 0 0 4 4 4 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 EFA86841.1 - 1.9e-05 24.2 5.6 0.18 11.7 0.2 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFA86841.1 - 4.2e-05 24.0 0.5 0.01 16.3 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFA86841.1 - 0.00034 20.8 3.0 4.7 7.6 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFA86841.1 - 0.0022 17.8 1.6 5.2 7.1 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFA86841.1 - 0.0038 17.2 7.3 0.48 10.7 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFA86841.1 - 1.1 9.4 3.3 3.6 7.8 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFA86841.1 - 2 8.8 6.4 19 5.8 0.3 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFA86841.1 - 6.9 7.5 6.1 67 4.4 0.0 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat PX PF00787.24 EFA86842.1 - 2.7e-16 59.6 0.1 4.2e-16 58.9 0.1 1.3 1 0 0 1 1 1 1 PX domain ALS2CR11 PF15729.5 EFA86842.1 - 0.093 11.9 2.4 0.12 11.5 2.4 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 Spc24 PF08286.11 EFA86842.1 - 0.34 11.2 4.1 0.65 10.3 4.1 1.6 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Wtap PF17098.5 EFA86842.1 - 0.59 10.0 6.7 1.9 8.4 4.2 2.3 1 1 1 2 2 2 0 WTAP/Mum2p family bZIP_1 PF00170.21 EFA86842.1 - 1.7 8.8 8.0 12 6.1 0.2 3.1 2 1 1 3 3 3 0 bZIP transcription factor Cyclin_N PF00134.23 EFA86843.1 - 1.1e-44 151.2 3.3 1.8e-44 150.6 1.3 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFA86843.1 - 1.4e-35 122.0 0.4 1.4e-35 122.0 0.4 1.6 2 0 0 2 2 2 1 Cyclin, C-terminal domain BRE PF06113.12 EFA86843.1 - 0.021 13.7 1.4 0.033 13.0 1.4 1.3 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) TMF_DNA_bd PF12329.8 EFA86844.1 - 0.08 12.9 4.2 0.1 12.6 4.2 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4407 PF14362.6 EFA86844.1 - 0.56 9.5 4.0 0.51 9.6 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 EFA86844.1 - 0.57 10.4 3.9 0.72 10.1 3.9 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MPS2 PF17060.5 EFA86844.1 - 1.1 8.4 3.6 1.5 8.0 3.6 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 Nup88 PF10168.9 EFA86844.1 - 1.6 6.5 5.1 1.9 6.2 5.1 1.1 1 0 0 1 1 1 0 Nuclear pore component SRP-alpha_N PF04086.13 EFA86844.1 - 2.4 8.0 9.3 3 7.7 9.3 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Csm1_N PF18504.1 EFA86844.1 - 4 7.8 7.7 5.5 7.4 7.7 1.2 1 0 0 1 1 1 0 Csm1 N-terminal domain Ndc1_Nup PF09531.10 EFA86844.1 - 8.7 4.9 15.6 11 4.6 15.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FNIP PF05725.12 EFA86848.1 - 5.3e-61 202.6 30.4 6.1e-14 51.9 0.7 8.3 6 2 2 8 8 8 8 FNIP Repeat F-box PF00646.33 EFA86848.1 - 0.00022 21.0 0.5 0.00057 19.7 0.5 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFA86848.1 - 0.0052 16.6 1.9 0.01 15.7 0.5 2.1 2 0 0 2 2 2 1 F-box-like PIP5K PF01504.18 EFA86849.1 - 2.9e-27 95.6 17.6 2.9e-27 95.6 17.6 4.1 2 2 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF1604 PF07713.13 EFA86852.1 - 2.6e-34 116.9 1.3 2.6e-34 116.9 1.3 4.2 3 1 1 4 4 4 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EFA86852.1 - 0.00014 21.7 0.1 0.00028 20.7 0.1 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFA86852.1 - 0.6 10.2 0.0 0.6 10.2 0.0 5.6 5 1 0 5 5 5 0 G-patch domain Laminin_G_3 PF13385.6 EFA86853.1 - 8.4e-14 52.0 1.3 2.6e-13 50.4 0.2 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EFA86853.1 - 1.3e-09 38.7 0.0 3e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EFA86853.1 - 0.0011 19.2 0.0 0.003 17.8 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain Multi_Drug_Res PF00893.19 EFA86853.1 - 0.052 14.2 1.4 0.14 12.8 1.4 1.7 1 0 0 1 1 1 0 Small Multidrug Resistance protein Methyltransf_11 PF08241.12 EFA86853.1 - 0.15 12.7 0.0 0.37 11.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain eRF1_1 PF03463.15 EFA86854.1 - 8.1e-42 142.3 1.0 2.2e-41 140.8 1.0 1.8 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EFA86854.1 - 7.9e-26 90.9 0.1 1.3e-25 90.2 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFA86854.1 - 1.9e-23 83.1 0.0 4.6e-23 81.9 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 7TM_GPCR_Srx PF10328.9 EFA86854.1 - 0.063 12.9 0.3 0.11 12.1 0.3 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DNA_ligase_aden PF01653.18 EFA86855.1 - 2.3e-69 233.9 0.0 3.8e-69 233.2 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 EFA86855.1 - 5.4e-27 93.5 0.8 3.2e-26 91.0 1.1 2.3 2 0 0 2 2 2 1 NAD-dependent DNA ligase OB-fold domain BRCT PF00533.26 EFA86855.1 - 1.7e-11 44.3 0.0 5.8e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain HHH_2 PF12826.7 EFA86855.1 - 5.6e-09 36.0 0.0 3.1e-08 33.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif TIG PF01833.24 EFA86855.1 - 8.9e-09 35.3 37.9 6.4e-05 23.0 0.4 6.1 7 0 0 7 7 7 4 IPT/TIG domain HHH_5 PF14520.6 EFA86855.1 - 1.6e-08 35.0 0.1 5e-06 27.0 0.1 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain PTCB-BRCT PF12738.7 EFA86855.1 - 0.0024 17.8 0.0 0.0059 16.5 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain Lectin_C PF00059.21 EFA86855.1 - 0.014 16.1 0.1 0.051 14.3 0.1 2.0 1 0 0 1 1 1 0 Lectin C-type domain EGF_Tenascin PF18720.1 EFA86855.1 - 0.048 13.7 8.3 0.15 12.1 8.3 1.9 1 0 0 1 1 1 0 Tenascin EGF domain PEGA PF08308.11 EFA86855.1 - 0.12 12.3 0.2 3.2 7.7 0.0 2.9 2 0 0 2 2 2 0 PEGA domain EB PF01683.18 EFA86855.1 - 5.6 7.3 12.2 0.67 10.3 6.6 2.2 2 0 0 2 2 2 0 EB module RVT_1 PF00078.27 EFA86856.1 - 1.9e-41 142.0 0.4 5.3e-41 140.6 0.4 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 EFA86856.1 - 0.028 13.9 0.1 0.077 12.5 0.1 1.7 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family zf-C2H2_9 PF16293.5 EFA86856.1 - 8.9 6.2 7.2 3.3 7.6 1.0 3.3 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) DUF3439 PF11921.8 EFA86857.1 - 2.4 8.1 7.8 22 5.0 6.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Tir_receptor_C PF07489.11 EFA86857.1 - 7.7 6.4 15.3 12 5.8 15.3 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Mycetozoa/Polysphondylium_pallidum_PN500-PolPal_Dec2009/GCA_000004825.1_PolPal_Dec2009_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Mycetozoa/Polysphondylium_pallidum_PN500-PolPal_Dec2009/GCA_000004825.1_PolPal_Dec2009_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Mycetozoa/Polysphondylium_pallidum_PN500-PolPal_Dec2009/GCA_000004825.1_PolPal_Dec2009_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Mycetozoa/Polysphondylium_pallidum_PN500-PolPal_Dec2009/GCA_000004825.1_PolPal_Dec2009_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 10:27:35 2019 # [ok]